                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  ANTIBODIES

<130>  9869SG4717

<150>  10201607147P
<151>  2016-08-26

<150>  10201700393P
<151>  2017-01-17

<150>  10201700521V
<151>  2017-01-20

<150>  10201703234U
<151>  2017-05-19

<160>  150   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  1

Gly Phe Thr Phe Asn Thr Tyr Thr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  2

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  3

Ala Arg Gly Tyr Arg Tyr Ala Ala Met Asp Tyr 
1               5                   10      


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  4

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  5

Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Tyr 
    


<210>  6
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  6

Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys 
        35              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  7

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  8

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Tyr Ala Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  9
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  9
gaggtgcagc tggagcagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcaat acctatacca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtaatg gtggtggtag tacctactat      180

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acggccatgt attactgtgc aagaggctat      300

aggtacgctg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 48

<400>  10

His Cys Pro Pro Lys Leu Thr Glu Phe His Pro His Ser Gly Pro 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 49

<400>  11

Pro His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 67

<400>  12

Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu Asp Pro 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 68

<400>  13

Tyr Arg Glu Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 69

<400>  14

Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro Glu Leu 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 29

<400>  15

Asp Pro Ala Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope; Peptide Number: 31

<400>  16

His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
1               5                   10                  15  


<210>  17
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  17
gatattttga tgacccaaac tcctctctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttggaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctccttatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cactggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acatgctccg      300

tggacgttcg gtggaggcac caagctggaa atcagac                               337


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  18

Gln Ser Ile Asn Asn Asn 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  19

Phe Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  20

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  21

Asp Ile Val Met Thr Gln Thr Thr Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gly Val Ser Leu Ser Cys Arg Ala Ser 
            20                  25      


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  22

Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  23

Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr Glu Asp Phe Gly 
            20                  25                  30          


Met Tyr Phe Cys 
        35      


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  24

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  25

Asp Ile Val Met Thr Gln Thr Thr Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gly Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  26
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  26
gatattgtga tgacccagac tacagccacc ctgtctgtga ctccaggaga tggcgtcagt       60

ctttcctgca gggccagcca aagtattaac aacaacctac actggtatca acaaaaatca      120

catgagtctc caagacttct catcaagttt gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggcctctcac gttcggtgct      300

gggaccaagc tggagctgaa ac                                               322


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  27

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  28

Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  29

Ala Arg Glu Gly Pro Leu Tyr Tyr Gly Pro Ser Tyr Gly Gly Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  30

Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  31

Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Gly Ala 
1               5                   10                  15      


Ser 
    


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  32

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Arg Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Leu Tyr Tyr Cys 
        35              


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  33

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  34
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  34

Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Gly 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Pro Leu Tyr Tyr Gly Pro Ser Tyr Gly Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 125 


<210>  35
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  35
gaagtgcagc tgttggagac tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatgcca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg gggcgcatcc attagtagtg gtggtagcac ctactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cctgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccctgtatt actgtgcaag agagggtccc      300

ctttactacg gtcctagcta cggagggtac tactttgact actggggcca aggcaccact      360

ctcacagtct cctca                                                       375


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  36

Gln Arg Leu Val Tyr Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  37

Lys Val Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  38

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  39
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  40

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  41
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  41

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Phe Cys 
        35      


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  42

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  44
gacattgtga tgacacagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaggcttgta tacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaac                               337


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  45

Gly Phe Ser Phe Ser Asp Tyr Trp 
1               5               


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  46

Ile Arg Leu Lys Ser Ser Asn Tyr Ala Thr 
1               5                   10  


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  47

Thr Arg Gly Asp Tyr 
1               5   


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  48

Asp Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  49

Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Glu 
    


<210>  50
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  50

His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Glu Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp 
            20                  25                  30          


Thr Gly Phe Tyr Tyr Cys 
        35              


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  51

Asp Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Ser Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Gly Phe Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  52
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  52
gacgtgatgc tggtggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cagtttcagt gactactgga tgaactgggt ccgccagtct      120

ccagagaagg ggcttgaatg ggttgctgag attagattga aatctagtaa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttt accatctcaa gagatgattc cgaaagtagt      240

gtctacctgc aaatgaacaa cttaagacct gaagacactg gcttttatta ctgtaccagg      300

ggggactatt ggggtcaagg aacctcagtc accgtctctt ca                         342


<210>  53
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gly Val Ser Leu Ser Cys Arg Ala Ser 
            20                  25      


<210>  54
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  54

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gly Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  55
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  55
gatattgtga tgacccagtc tccagccacc ctgtctgtga ctccaggaga tggcgtcagt       60

ctttcctgca gggccagcca aagtattaac aacaacctac actggtatca acaaaaatca      120

catgagtctc caagacttct catcaagttt gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggcctctcac gttcggtgct      300

gggaccaagc tggagctgaa ac                                               322


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  56

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  57

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  58

Thr Arg Asp Gly Tyr Tyr Pro Phe Ala Tyr 
1               5                   10  


<210>  59
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  59

Glu Val Gln Leu Glu Glu Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  60

Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  61
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  61

Ser Thr Asn Gln Lys Phe Lys Asp Lys Ala Lys Leu Thr Ala Val Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Thr Asn Glu Asp 
            20                  25                  30          


Ser Ala Val Phe Tyr Cys 
        35              


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  62

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  63

Glu Val Gln Leu Glu Glu Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Thr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Tyr Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  64
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  64
gaagtgcagc tggaggagtc agggactgtg ctggcaaggc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta catttttacc agctactgga tgcactggat aaaacagagg      120

cctggacagg gtctggaatg gattggcgct atttatcctg gaaatagtga tactagtact      180

aatcagaagt tcaaggacaa ggccaaactg actgcagtca catccaccag cactgcctat      240

ttggaactca gcagcctgac aaatgaggac tcagcggtct tttactgtac aagagatggt      300

tactacccgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  65

Gln Ser Leu Val Tyr Ile Asn Gly Asp Thr Tyr 
1               5                   10      


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  66

Arg Val Ser 
1           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  67

Ser Gln Thr Lys His Val Pro Tyr Thr 
1               5                   


<210>  68
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  68

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  69

Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  70

Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
1               5                   10  


<210>  71
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  71

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Lys His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  72
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  72
gacattgtgc tgacccaatc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta tatattaatg gagacaccta ttttcattgg      120

tacttgcaga agccaggcca gtctccaaag ctcctgatct acagagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaactaa acatgttccg      300

tacacgttcg gaggggggac caagctggaa atgaaacg                              338


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  73

Gly Tyr Glu Phe Ser Lys Tyr Trp 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  74

Ile Phe Pro Gly Asp Gly Asp Ile 
1               5               


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  75

Ala Arg Trp Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  76
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  76

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  77

Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gln 
    


<210>  78
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  78

Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Glu 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  79

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Glu Phe Ser Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Phe Pro Gly Asp Gly Asp Ile Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  80
gaggtccagc tgcagcagcc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgaattcagt aagtactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttttccag gagacggtga tattaattac      180

aatggaaaat tcaagggtaa agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctaac atctgaggaa tctgcggtct atttctgtgc aagatggtac      300

tacggtagta actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  81

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  82
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  82

Trp Ala Ser 
1           


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  83

Gln Gln Tyr Tyr Ala Tyr Arg Thr 
1               5               


<210>  84
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  84

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Ile Thr Met Ser Cys Lys Ser Ser 
            20                  25      


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  85

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  86
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  86

Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  87
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  87

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  88
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  88
gacattgtga tgacccagac tccatcctcc ctagctgtgt cagttggaga gaagattact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatgcctat      300

cggacgttcg gtggaggcac caagctggaa atcaaac                               337


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  89

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  90

Ile Tyr Pro Gly Asn Asn Asp Thr 
1               5               


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  91

Thr Arg Asp Gly Phe Tyr Pro Phe Ala Tyr 
1               5                   10  


<210>  92
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  92

Glu Val Lys Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  93

Met His Trp Ile Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  94
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  94

Ser Thr Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Thr Asn Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  95

Glu Val Lys Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Asn Asp Thr Ser Thr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Phe Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  96
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  96
gaggttaagc tgcagcagtc tgggactgtg ctggcaaggc ctgggacttc agtgaagatg       60

tcttgcaagg cttctggcta catttttacc agctactgga tgcattggat aaaagagagg      120

cctggacagg gtctggaatg gattggcgct atttatcctg gaaataatga tactagtact      180

aatcagaagt tcaagggcaa ggccaaactg actgcagtca catccaccag cactgcctat      240

ttggaactca gcagcctgac aaatgaggac tcagcggtct attactgtac aagagatggt      300

ttttacccgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  97
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  97

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  98
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  98

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Lys His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  99
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  99
gatattgtgc tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta tatattaatg gagacaccta ttttcattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acagagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaactaa acatgttccg      300

tacacgttcg gaggggggac caagctggaa atgaaacg                              338


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  100

Gly Tyr Ile Phe Thr Ser Tyr Tyr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  101

Ile Asn Pro Ile Thr Gly Gly Thr 
1               5               


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  102

Ala Arg Met Gly Arg Asp Ala Met Asp Tyr 
1               5                   10  


<210>  103
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  103

Gln Val Gln Leu Lys Gln Ser Gly Ser Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  104

Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  105

Asp Phe Asn Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Leu Ala Ala 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  106

Gln Val Gln Leu Lys Gln Ser Gly Ser Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ile Thr Gly Gly Thr Asp Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Leu Ala Ala Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Gly Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  107
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  107
caggtgcagc tgaagcagtc agggtctgaa ctggtgaaac ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta catcttcacc agctactata tgtactgggt gaagcagagg      120

cctggacaag gccttgagtg gattgggggg attaatccta tcactggtgg tactgacttc      180

aatgagaagt tcaaggacaa ggccacactg actctggccg catcctccag cacagcctac      240

atacaactca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaatggga      300

cgggatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc                 350


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  108

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  109
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  109

Leu Val Ser 
1           


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  110

Gln His Ile Arg Glu Leu Tyr Thr 
1               5               


<210>  111
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  111

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser 
            20                  25      


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  112

Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  113
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  113

Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  114
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  114

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  115
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  115
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gctttacacg      300

ttcggagggg ggaccaagct ggaaataaaa cg                                    332


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  116

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  117

Ile Asn Pro Thr Thr Gly Gly Thr 
1               5               


<210>  118
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  118

Gln Val Gln Leu Lys Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  119

Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  120

Asp Phe Asn Glu Asn Phe Lys Asn Lys Ala Thr Leu Thr Leu Ala Thr 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  121
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  121

Gln Val Gln Leu Lys Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Thr Thr Gly Gly Thr Asp Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Leu Ala Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Gly Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  122
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  122
caggtgcagc tgaaggagtc aggggctgaa ctggtgaaac ctgggacttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc agctactata tgtactggtt gaagcagagg      120

cctggacaag gccttgagtg gattgggggg attaatccta ccactggtgg tactgacttc      180

aatgagaact tcaagaacaa ggccacactg actttggcca catcctccag cacagcctac      240

atacaactca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaatggga      300

cgggatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  123

Gln His Ile Arg Glu Leu Thr Arg 
1               5               


<210>  124
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  124

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser 
            20                  25      


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  125

Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  126
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  126

Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  127
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  127

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105             


<210>  128
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  128
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      300

tcggaggggg gaccaagctg gaaa                                             324


<210>  129
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  129

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  130
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  130

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Thr Thr Gly Gly Thr Asp Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Leu Ala Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Gly Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  131
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  131
gaggttcagc tgcagcagtc tggggctgaa ctggtgaaac ctgggacttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc agctactata tgtactggtt gaagcagagg      120

cctggacaag gccttgagtg gattgggggg attaatccta ccactggtgg tactgacttc      180

aatgagaact tcaagaacaa ggccacactg actttggcca catcctccag cacagcctac      240

atacaactca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaatggga      300

cgggatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  132

Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
1               5                   10  


<210>  133
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  133

Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ile Thr Gly Gly Thr Asp Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Leu Ala Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Gly Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  134
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  134
gaggttcagc tgcagcagtc tgggtctgaa ctggtgaaac ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta catcttcacc agctactata tgtactgggt gaagcagagg      120

cctggacaag gccttgagtg gattgggggg attaatccta tcactggtgg tactgacttc      180

aatgagaagt tcaagaacaa ggccacactg actctggcca catcctccag cacagcctac      240

atacatctca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaatggga      300

cgggatgcta tggactactg gggtcaagga acctcagtca ccgtctcc                   348


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  135

Asp Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  136

Ile Leu Tyr Ser Gly Ser Thr 
1               5           


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  137

Ala Ser Leu Gly Arg Gly Gly Ser 
1               5               


<210>  138
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  138

Leu Glu Val Lys Leu Glu Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25      


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  139

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  140
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  140

Thr Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu His Leu Asp Ser Val Thr Thr Glu Asp 
            20                  25                  30          


Ala Ala Thr Tyr Tyr Cys 
        35              


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  141

Trp Gly Gln Gly Thr Thr Leu Ala Val Ser Ser 
1               5                   10      


<210>  142
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  142

Leu Glu Val Lys Leu Glu Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Asp Tyr Ser Ile Thr Ser 
            20                  25                  30          


Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Leu Tyr Ser Gly Ser Thr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Asp Ser Val Thr Thr Glu Asp Ala Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Leu Gly Arg Gly Gly Ser Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Ala Val Ser Ser 
        115     


<210>  143
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable

<400>  143
cttgaggtta agctggagca gtcaggacct ggcctggtga aaccttctca gtctctgtcc       60

ctcacctgca ctgtcactga ctactcaatc accagtgatt atgcctggaa ctggatccgg      120

caatttccag gaaacaaact ggagtggatg ggttacatac tctacagtgg ttccactacg      180

tacaatccgt ctctcaaaag tcgagtctct atcactcgag acacatccaa gaaccagttc      240

ttcctgcact tggattctgt gactactgag gacgctgcca catattactg tgcaagcctc      300

gggcgtgggg ggtcctgggg ccagggcacc actctcgcag tctcctca                   348


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  144

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  145

Phe Gln Gly Ser His Ala Pro Trp Thr 
1               5                   


<210>  146
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  146

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  147
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  147

Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  148
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  148

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  149

Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
1               5                   10  


<210>  150
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable

<400>  150

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         


