                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  METHOD OF IMPROVING METHYLTRANSFERASE ACTIVITY

<130>  20843

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  394
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Thr Leu Gln Glu Ser Asp Lys Phe Ala Thr Lys Ala Ile His Ala 
1               5                   10                  15      


Gly Glu His Val Asp Val His Gly Ser Val Ile Glu Pro Ile Ser Leu 
            20                  25                  30          


Ser Thr Thr Phe Lys Gln Ser Ser Pro Ala Asn Pro Ile Gly Thr Tyr 
        35                  40                  45              


Glu Tyr Ser Arg Ser Gln Asn Pro Asn Arg Glu Asn Leu Glu Arg Ala 
    50                  55                  60                  


Val Ala Ala Leu Glu Asn Ala Gln Tyr Gly Leu Ala Phe Ser Ser Gly 
65                  70                  75                  80  


Ser Ala Thr Thr Ala Thr Ile Leu Gln Ser Leu Pro Gln Gly Ser His 
                85                  90                  95      


Ala Val Ser Ile Gly Asp Val Tyr Gly Gly Thr His Arg Tyr Phe Thr 
            100                 105                 110         


Lys Val Ala Asn Ala His Gly Val Glu Thr Ser Phe Thr Asn Asp Leu 
        115                 120                 125             


Leu Asn Asp Leu Pro Gln Leu Ile Lys Glu Asn Thr Lys Leu Val Trp 
    130                 135                 140                 


Ile Glu Thr Pro Thr Asn Pro Thr Leu Lys Val Thr Asp Ile Gln Lys 
145                 150                 155                 160 


Val Ala Asp Leu Ile Lys Lys His Ala Ala Gly Gln Asp Val Ile Leu 
                165                 170                 175     


Val Val Asp Asn Thr Phe Leu Ser Pro Tyr Ile Ser Asn Pro Leu Asn 
            180                 185                 190         


Phe Gly Ala Asp Ile Val Val His Ser Ala Thr Lys Tyr Ile Asn Gly 
        195                 200                 205             


His Ser Asp Val Val Leu Gly Val Leu Ala Thr Asn Asn Lys Pro Leu 
    210                 215                 220                 


Tyr Glu Arg Leu Gln Phe Leu Gln Asn Ala Ile Gly Ala Ile Pro Ser 
225                 230                 235                 240 


Pro Phe Asp Ala Trp Leu Thr His Arg Gly Leu Lys Thr Leu His Leu 
                245                 250                 255     


Arg Val Arg Gln Ala Ala Leu Ser Ala Asn Lys Ile Ala Glu Phe Leu 
            260                 265                 270         


Ala Ala Asp Lys Glu Asn Val Val Ala Val Asn Tyr Pro Gly Leu Lys 
        275                 280                 285             


Thr His Pro Asn Tyr Asp Val Val Leu Lys Gln His Arg Asp Ala Leu 
    290                 295                 300                 


Gly Gly Gly Met Ile Ser Phe Arg Ile Lys Gly Gly Ala Glu Ala Ala 
305                 310                 315                 320 


Ser Lys Phe Ala Ser Ser Thr Arg Leu Phe Thr Leu Ala Glu Ser Leu 
                325                 330                 335     


Gly Gly Ile Glu Ser Leu Leu Glu Val Pro Ala Val Met Thr His Gly 
            340                 345                 350         


Gly Ile Pro Lys Glu Ala Arg Glu Ala Ser Gly Val Phe Asp Asp Leu 
        355                 360                 365             


Val Arg Ile Ser Val Gly Ile Glu Asp Thr Asp Asp Leu Leu Glu Asp 
    370                 375                 380                 


Ile Lys Gln Ala Leu Lys Gln Ala Thr Asn 
385                 390                 


<210>  2
<211>  421
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Ser Asp Phe Leu Asn Ala Asp Gly Ser Leu Asn Val Asp Lys Val 
1               5                   10                  15      


Arg Glu Glu Phe Pro Ile Leu Lys Arg Thr Val Arg Asp Gly Lys Pro 
            20                  25                  30          


Leu Ala Tyr Leu Asp Ser Gly Ala Thr Ser Gln Arg Pro Glu Arg Val 
        35                  40                  45              


Trp Arg Ala Glu Glu His Phe Val Leu His Thr Asn Ala Pro Val His 
    50                  55                  60                  


Arg Gly Ala Tyr Gln Leu Ala Glu Glu Ala Thr Asp Ala Tyr Glu Gly 
65                  70                  75                  80  


Ala Arg Glu Lys Ile Ala Ala Phe Val Gly Ala Glu Gln His Glu Ile 
                85                  90                  95      


Ala Phe Thr Lys Asn Ala Thr Glu Ala Leu Asn Leu Val Ala Tyr Thr 
            100                 105                 110         


Leu Gly Asp Asp Arg Ser Gly Lys Tyr Arg Val Gln Ala Gly Asp Thr 
        115                 120                 125             


Val Val Ile Thr Glu Leu Glu His His Ala Asn Leu Val Pro Trp Gln 
    130                 135                 140                 


Glu Leu Cys Arg Arg Thr Gly Ala Thr Leu Lys Trp Tyr Lys Val Thr 
145                 150                 155                 160 


Glu Asp Gly Arg Ile Asp Leu Asp Ser Leu Glu Leu Asp Glu Thr Val 
                165                 170                 175     


Lys Val Val Ala Phe Thr His Gln Ser Asn Val Thr Gly Ala Val Ala 
            180                 185                 190         


Asp Val Pro Glu Leu Val Arg Arg Ala Lys Ala Val Gly Ala Leu Thr 
        195                 200                 205             


Val Leu Asp Ala Cys Gln Ser Val Pro His Met Pro Val Asn Phe His 
    210                 215                 220                 


Glu Leu Asp Val Asp Phe Ser Ala Phe Ser Gly His Lys Met Leu Gly 
225                 230                 235                 240 


Pro Ala Gly Val Gly Val Val Tyr Ala Lys Ser Pro Ile Leu Asp Glu 
                245                 250                 255     


Leu Pro Pro Phe Leu Thr Gly Gly Ser Met Ile Glu Val Val Thr Met 
            260                 265                 270         


Glu Gly Ser Thr Tyr Ala Ala Ala Pro Gln Arg Phe Glu Ala Gly Thr 
        275                 280                 285             


Gln Met Thr Ser Gln Val Val Gly Leu Gly Ala Ala Val Asp Met Leu 
    290                 295                 300                 


Asn Glu Ile Gly Met Glu Ala Ile Ala Ala His Glu His Ala Leu Thr 
305                 310                 315                 320 


Ala Tyr Ala Leu Glu Lys Leu Thr Ala Ile Lys Gly Leu Thr Ile Ala 
                325                 330                 335     


Gly Pro Leu Thr Ala Glu Gln Arg Gly Gly Ala Ile Ser Phe Gly Val 
            340                 345                 350         


Glu Gly Ile His Pro His Asp Leu Gly Gln Val Leu Asp Asp Gln Gly 
        355                 360                 365             


Val Asn Ile Arg Val Gly His His Cys Ala Trp Pro Val His Arg Ser 
    370                 375                 380                 


Met Asn Val Gln Ser Thr Ala Arg Ala Ser Phe Tyr Leu Tyr Asn Thr 
385                 390                 395                 400 


Phe Glu Glu Ile Asp Arg Leu Ala Ala Ala Ile Glu Lys Ala Lys Gln 
                405                 410                 415     


Phe Phe Gly Val Glu 
            420     


<210>  3
<211>  392
<212>  PRT
<213>  Streptomyces coelicolor

<400>  3

Met Ser Asp Ser Ala Thr Thr Asp Ser Ala Gly Thr Gly Gly Glu Arg 
1               5                   10                  15      


Ser Ala Ser Ala Pro Gly Asp Gly Thr Arg Ala Val Arg Ala Gly Leu 
            20                  25                  30          


Pro Glu Pro Val Lys His Glu Pro Thr Leu Pro Gly Pro Val Phe Ala 
        35                  40                  45              


Ala His Phe His Leu Pro Gly Asp Pro Thr Gly Pro Tyr Thr Tyr Gly 
    50                  55                  60                  


Arg Asp Glu Asn Pro Thr Trp Thr Arg Leu Glu Ser Ala Ile Gly Glu 
65                  70                  75                  80  


Leu Glu Ala Pro Gly Glu Ala Gly Val Glu Thr Leu Val Phe Ala Ser 
                85                  90                  95      


Gly Met Ala Ala Ile Ser Ser Val Leu Phe Ser Gln Leu Arg Ala Gly 
            100                 105                 110         


Asp Thr Ala Val Leu Pro Asp Asp Gly Tyr Gln Ala Leu Pro Leu Val 
        115                 120                 125             


Arg Ala Gln Leu Glu Ala Tyr Gly Ile Glu Val Arg Thr Ala Pro Thr 
    130                 135                 140                 


Gly Arg Asp Ala Gln Leu Asp Val Leu Asp Gly Ala Lys Leu Leu Trp 
145                 150                 155                 160 


Ile Glu Thr Pro Ser Asn Pro Gly Leu Asp Val Cys Asp Val Arg Arg 
                165                 170                 175     


Leu Val Glu Ala Ala His Ala Gly Gly Ala Leu Val Ala Val Asp Asn 
            180                 185                 190         


Thr Leu Ala Thr Pro Leu Gly Gln Arg Pro Leu Glu Leu Gly Ala Asp 
        195                 200                 205             


Phe Ser Val Ala Ser Gly Thr Lys Gln Leu Thr Gly His Gly Asp Val 
    210                 215                 220                 


Leu Leu Gly Tyr Val Ala Gly Arg Asp Ala Gly Ala Met Ala Ala Val 
225                 230                 235                 240 


Arg Arg Trp Arg Lys Ile Val Gly Ala Ile Pro Gly Pro Met Glu Ala 
                245                 250                 255     


Trp Leu Ala His Arg Ser Ile Ala Thr Leu Gln Leu Arg Val Asp Arg 
            260                 265                 270         


Gln Asp Ser Thr Ala Leu Lys Val Ala Glu Ala Leu Arg Thr Arg Pro 
        275                 280                 285             


Glu Ile Thr Gly Leu Arg Tyr Pro Gly Leu Pro Asp Asp Pro Ser His 
    290                 295                 300                 


Lys Val Ala Ser Gln Gln Met Leu Arg Tyr Gly Cys Val Val Ser Phe 
305                 310                 315                 320 


Thr Leu Pro Ser Arg Ala Arg Ala Asp Arg Phe Leu Asp Ala Leu Arg 
                325                 330                 335     


Leu Val Glu Gly Ala Thr Ser Phe Gly Gly Val Arg Ser Thr Ala Glu 
            340                 345                 350         


Arg Arg Gly Arg Trp Gly Gly Asp Ala Val Pro Glu Gly Phe Ile Arg 
        355                 360                 365             


Leu Ser Val Gly Ala Glu Asp Pro Asp Asp Leu Val Ala Asp Leu Leu 
    370                 375                 380                 


Arg Ala Leu Asp Glu Thr Thr Glu 
385                 390         


<210>  4
<211>  390
<212>  PRT
<213>  Streptomyces griseus

<400>  4

Met Arg Gly Thr Pro Val His His Arg Gly Ser Ser Glu Gly Ala Gly 
1               5                   10                  15      


Met Ser Thr Met Gly Asp Gly Thr Arg Ala Val Arg Ala Gly Leu Pro 
            20                  25                  30          


Glu Pro Glu Gln Phe Gly Pro Thr Leu Pro Gly Pro Val Phe Ala Ala 
        35                  40                  45              


His Phe His Leu Ser Gly Glu Pro Val Gly Pro Tyr Thr Tyr Gly Arg 
    50                  55                  60                  


Glu Thr Asn Pro Thr Trp Thr His Leu Glu Arg Ala Ile Gly Glu Leu 
65                  70                  75                  80  


Glu Ala Pro Gly Glu Glu Val Gly Thr Thr Val Phe Ala Ser Gly Met 
                85                  90                  95      


Ala Ala Ile Thr Ala Val Leu Leu Ser Gln Val Arg Ser Gly Asp Ala 
            100                 105                 110         


Val Val Leu Pro Asp Asp Gly Tyr Gln Ala Leu Pro Leu Val Arg Glu 
        115                 120                 125             


Gln Leu Glu Ala Tyr Gly Val Glu Val Arg Thr Ala Pro Thr Gly Gly 
    130                 135                 140                 


Asp Ala Gln Gln Ala Leu Leu Thr Gly Ala Lys Leu Leu Trp Ile Glu 
145                 150                 155                 160 


Ser Pro Ser Asn Pro Gly Leu Asp Val Cys Asp Ile Arg Arg Leu Ala 
                165                 170                 175     


Gly Ala Ala His Ala Ala Gly Ala Leu Val Ala Val Asp Asn Thr Leu 
            180                 185                 190         


Ala Thr Pro Ile Gly Gln Arg Pro Leu Glu Leu Gly Ala Asp Phe Ser 
        195                 200                 205             


Val Ala Ser Asp Thr Lys Gly Met Thr Gly His Gly Asp Ile Leu Leu 
    210                 215                 220                 


Gly His Val Thr Cys Arg Asp Pro Arg Leu Thr Ala Asp Val Arg Arg 
225                 230                 235                 240 


Trp Arg Lys Val Val Gly Ala Ile Pro Gly Pro Met Glu Ala Trp Leu 
                245                 250                 255     


Ala His Arg Ser Leu Ser Thr Leu Gln Leu Arg Val Asp Arg Gln Cys 
            260                 265                 270         


Ala Thr Ala Leu Ala Leu Ala Glu Ala Leu Thr Glu Arg Ala Glu Val 
        275                 280                 285             


Thr Gly Leu Arg Tyr Pro Gly Leu Pro Thr Asp Pro Ser His Val Val 
    290                 295                 300                 


Ala Gly Arg Gln Met Arg Arg Phe Gly Ser Val Val Ser Phe Glu Leu 
305                 310                 315                 320 


Ala Asp Arg Glu Thr Ala Glu Arg Phe Leu Ser Ala Leu Arg Leu Val 
                325                 330                 335     


Asp Asp Ala Thr Ser Phe Gly Gly Val Arg Ser Thr Ala Glu Arg Arg 
            340                 345                 350         


Gly Arg Trp Gly Gly Asp Ala Val Ala Glu Gly Phe Ile Arg Phe Ser 
        355                 360                 365             


Val Gly Ala Glu Asp Pro Glu Asp Leu Leu Ser Asp Val Glu Gln Ala 
    370                 375                 380                 


Leu Asn Ala Ala Val Arg 
385                 390 


<210>  5
<211>  379
<212>  PRT
<213>  Bacillus subtilis

<400>  5

Met Lys Lys Lys Thr Leu Met Ile His Gly Gly Ile Thr Gly Asp Glu 
1               5                   10                  15      


Lys Thr Gly Ala Val Ser Val Pro Ile Tyr Gln Val Ser Thr Tyr Lys 
            20                  25                  30          


Gln Pro Lys Ala Gly Gln His Thr Gly Tyr Glu Tyr Ser Arg Thr Ala 
        35                  40                  45              


Asn Pro Thr Arg Thr Ala Leu Glu Ala Leu Val Thr Glu Leu Glu Ser 
    50                  55                  60                  


Gly Glu Ala Gly Tyr Ala Phe Ser Ser Gly Met Ala Ala Ile Thr Ala 
65                  70                  75                  80  


Val Met Met Leu Phe Asn Ser Gly Asp His Val Val Leu Thr Asp Asp 
                85                  90                  95      


Val Tyr Gly Gly Thr Tyr Arg Val Met Thr Lys Val Leu Asn Arg Leu 
            100                 105                 110         


Gly Ile Glu Ser Thr Phe Val Asp Thr Ser Ser Arg Glu Glu Val Glu 
        115                 120                 125             


Lys Ala Ile Arg Pro Asn Thr Lys Ala Ile Tyr Ile Glu Thr Pro Thr 
    130                 135                 140                 


Asn Pro Leu Leu Lys Ile Thr Asp Leu Thr Leu Met Ala Asp Ile Ala 
145                 150                 155                 160 


Lys Lys Ala Gly Val Leu Leu Ile Val Asp Asn Thr Phe Asn Thr Pro 
                165                 170                 175     


Tyr Phe Gln Gln Pro Leu Thr Leu Gly Ala Asp Ile Val Leu His Ser 
            180                 185                 190         


Ala Thr Lys Tyr Leu Gly Gly His Ser Asp Val Val Gly Gly Leu Val 
        195                 200                 205             


Val Thr Ala Ser Lys Glu Leu Gly Glu Glu Leu His Phe Val Gln Asn 
    210                 215                 220                 


Ser Thr Gly Gly Val Leu Gly Pro Gln Asp Ser Trp Leu Leu Met Arg 
225                 230                 235                 240 


Gly Ile Lys Thr Leu Gly Leu Arg Met Glu Ala Ile Asp Gln Asn Ala 
                245                 250                 255     


Arg Lys Ile Ala Ser Phe Leu Glu Asn His Pro Ala Val Gln Thr Leu 
            260                 265                 270         


Tyr Tyr Pro Gly Ser Ser Asn His Pro Gly His Glu Leu Ala Lys Thr 
        275                 280                 285             


Gln Gly Ala Gly Phe Gly Gly Met Ile Ser Phe Asp Ile Gly Ser Glu 
    290                 295                 300                 


Glu Arg Val Asp Ala Phe Leu Gly Asn Leu Lys Leu Phe Thr Ile Ala 
305                 310                 315                 320 


Glu Ser Leu Gly Ala Val Glu Ser Leu Ile Ser Val Pro Ala Arg Met 
                325                 330                 335     


Thr His Ala Ser Ile Pro Arg Glu Arg Arg Leu Glu Leu Gly Ile Thr 
            340                 345                 350         


Asp Gly Leu Ile Arg Ile Ser Val Gly Ile Glu Asp Ala Glu Asp Leu 
        355                 360                 365             


Leu Glu Asp Ile Gly Gln Ala Leu Glu Asn Ile 
    370                 375                 


<210>  6
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  7
<211>  507
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Ser Lys 
            340                 345                 350         


Leu Glu Ala Ser Thr Thr Lys Tyr Ala Asp Val Phe Gly Asn Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Thr Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Thr Glu Asp Gly Lys Leu Ser Gly Leu Val Thr Leu 
                405                 410                 415     


Ser Glu Leu Leu Arg Lys Leu Ser Ile Asn Asn Ser Asn Asn Asp Asn 
            420                 425                 430         


Thr Ile Lys Gly Lys Tyr Leu Asp Phe Lys Lys Leu Asn Asn Phe Asn 
        435                 440                 445             


Asp Val Ser Ser Tyr Asn Glu Asn Lys Ser Gly Lys Lys Lys Phe Ile 
    450                 455                 460                 


Lys Phe Asp Glu Asn Ser Lys Leu Ser Asp Leu Asn Arg Phe Phe Glu 
465                 470                 475                 480 


Lys Asn Ser Ser Ala Val Ile Thr Asp Gly Leu Lys Pro Ile His Ile 
                485                 490                 495     


Val Thr Lys Met Asp Leu Leu Ser Tyr Leu Ala 
            500                 505         


<210>  8
<211>  461
<212>  PRT
<213>  Streptomyces coelicolor

<400>  8

Met Gln Phe His Asp Ser Met Ile Ser Leu Val Gly Asn Thr Pro Leu 
1               5                   10                  15      


Val Arg Leu Asn Ser Val Ser Lys Gly Ile Arg Ala Thr Val Leu Ala 
            20                  25                  30          


Lys Val Glu Tyr Phe Asn Pro Gly Gly Ser Val Lys Asp Arg Ile Ala 
        35                  40                  45              


Leu Arg Met Ile Glu Ala Ala Glu Lys Ser Gly Glu Leu Gln Pro Gly 
    50                  55                  60                  


Gly Thr Ile Val Glu Pro Thr Ser Gly Asn Thr Gly Val Gly Leu Ala 
65                  70                  75                  80  


Ile Val Ala Gln Gln Lys Gly Tyr Lys Cys Ile Phe Val Cys Pro Asp 
                85                  90                  95      


Lys Val Ser Thr Asp Lys Ile Asn Val Leu Arg Ala Tyr Gly Ala Glu 
            100                 105                 110         


Val Val Val Cys Pro Thr Ala Val Asp Pro Glu His Pro Asp Ser Tyr 
        115                 120                 125             


Tyr Asn Val Ser Asp Arg Leu Val Arg Glu Thr Pro Gly Ala Trp Lys 
    130                 135                 140                 


Pro Asp Gln Tyr Ser Asn Pro Asn Asn Pro Leu Ser His Tyr His Ser 
145                 150                 155                 160 


Thr Gly Pro Glu Leu Trp Glu Gln Thr Glu Gly Lys Ile Thr His Phe 
                165                 170                 175     


Val Ala Gly Val Gly Thr Gly Gly Thr Ile Ser Gly Thr Gly Arg Tyr 
            180                 185                 190         


Leu Lys Asp Ala Ser Asp Gly Ala Val Thr Val Ile Gly Ala Asp Pro 
        195                 200                 205             


Glu Gly Ser Val Tyr Ser Gly Gly Ser Gly Arg Pro Tyr Leu Val Glu 
    210                 215                 220                 


Gly Val Gly Glu Asp Phe Trp Pro Thr Ala Tyr Asp Arg Glu Val Ala 
225                 230                 235                 240 


Asp Glu Ile Val Ala Val Ser Asp Lys Asp Ser Phe Gln Met Thr Arg 
                245                 250                 255     


Arg Leu Ala Lys Glu Glu Gly Leu Leu Val Gly Gly Ser Cys Gly Met 
            260                 265                 270         


Ala Val Val Ala Ala Leu Glu Val Ala Ala Arg Leu Gly Glu Asp Asp 
        275                 280                 285             


Val Val Val Val Leu Leu Pro Asp Ser Gly Arg Gly Tyr Leu Ser Lys 
    290                 295                 300                 


Ile Phe Asn Asp Glu Trp Met Ala Asp Tyr Gly Phe Leu Glu Asp Thr 
305                 310                 315                 320 


Gly Pro Ser Ala Arg Val Ala Glu Val Leu Asn His Lys Glu Gly Gly 
                325                 330                 335     


His Ile Pro Ser Leu Val His Met His Pro Asp Glu Thr Val Gly Gln 
            340                 345                 350         


Ala Ile Glu Val Leu Arg Glu Tyr Gly Val Ser Gln Met Pro Ile Val 
        355                 360                 365             


Lys Pro Gly Ala Gly His Pro Asp Val Met Ala Ala Glu Val Val Gly 
    370                 375                 380                 


Ser Val Val Glu Arg Glu Leu Leu Asp Ala Leu Phe Ala Lys Arg Ala 
385                 390                 395                 400 


Ser Leu Glu Asp Pro Leu Glu Lys His Met Ser Ala Pro Leu Pro Gln 
                405                 410                 415     


Val Gly Ser Gly Glu Pro Val Ala Asp Leu Met Ser Val Leu Gly Gly 
            420                 425                 430         


Ala Asp Ala Ala Ile Val Leu Val Glu Gly Lys Pro Thr Gly Val Val 
        435                 440                 445             


Ser Arg Gln Asp Leu Leu Ser Phe Leu Ala Lys Val Lys 
    450                 455                 460     


<210>  9
<211>  468
<212>  PRT
<213>  Streptomyces griseus

<400>  9

Met Gln Phe His Asp Ser Met Ile Ser Leu Val Gly Asn Thr Pro Leu 
1               5                   10                  15      


Val Arg Leu Arg Asn Val Thr Ala Gly Ile Gln Ala Thr Val Leu Ala 
            20                  25                  30          


Lys Val Glu Tyr Phe Asn Pro Gly Gly Ser Val Lys Asp Arg Ile Ala 
        35                  40                  45              


Leu Arg Met Ile Glu Ala Ala Glu Gln Ser Gly Glu Leu Lys Pro Gly 
    50                  55                  60                  


Gly Thr Ile Val Glu Pro Thr Ser Gly Asn Thr Gly Val Gly Leu Ala 
65                  70                  75                  80  


Ile Val Ala Gln Gln Lys Gly Tyr Lys Cys Ile Phe Val Cys Pro Asp 
                85                  90                  95      


Lys Val Ser Thr Asp Lys Ile Asn Val Leu Arg Ala Tyr Gly Ala Glu 
            100                 105                 110         


Val Val Val Cys Pro Thr Ala Val Asp Pro Glu His Pro Asp Ser Tyr 
        115                 120                 125             


Tyr Asn Val Ser Asp Arg Leu Val Thr Glu Thr Pro Gly Ala Trp Lys 
    130                 135                 140                 


Pro Asp Gln Tyr Ser Asn Pro Asn Asn Pro Arg Ser His Tyr Glu Thr 
145                 150                 155                 160 


Thr Gly Pro Glu Leu Trp Glu Gln Thr Glu Gly Lys Ile Thr His Phe 
                165                 170                 175     


Val Ala Gly Val Gly Thr Gly Gly Thr Ile Ser Gly Thr Gly Arg Tyr 
            180                 185                 190         


Leu Lys Glu Ile Ser Asp Gly Ala Val Gln Val Ile Gly Ala Asp Pro 
        195                 200                 205             


Glu Gly Ser Val Tyr Ser Gly Gly Ser Gly Arg Pro Tyr Leu Val Glu 
    210                 215                 220                 


Gly Val Gly Glu Asp Phe Trp Pro Ser Ala Tyr Asp Arg Asn Val Thr 
225                 230                 235                 240 


Asp Glu Ile Val Ala Val Ser Asp Lys Asp Ser Phe Gln Met Thr Arg 
                245                 250                 255     


Arg Leu Ala Lys Glu Glu Gly Leu Leu Val Gly Gly Ser Cys Gly Met 
            260                 265                 270         


Ala Val Val Gly Ala Leu Glu Val Ala Lys Arg Leu Gly Pro Asp Asp 
        275                 280                 285             


Val Val Val Val Leu Leu Pro Asp Ser Gly Arg Gly Tyr Leu Ser Lys 
    290                 295                 300                 


Ile Phe Asn Asp Glu Trp Met Ala Asp Tyr Gly Phe Leu Glu Asn Thr 
305                 310                 315                 320 


Gly Thr Ser Ala Asn Val Gly Ala Val Leu Asp Phe Lys Glu Gly Pro 
                325                 330                 335     


Met Pro Ser Leu Val His Met His Pro Glu Glu Thr Val Gly Glu Ala 
            340                 345                 350         


Ile Glu Val Leu Arg Glu Tyr Gly Val Ser Gln Met Pro Ile Val Lys 
        355                 360                 365             


Pro Gly Ala Gly His Pro Asp Val Met Ala Ala Glu Val Ile Gly Ser 
    370                 375                 380                 


Val Val Glu Arg Gln Leu Leu Asp Ala Leu Phe Thr Gln Arg Ala Ser 
385                 390                 395                 400 


Leu Ser Asp Pro Leu Glu Lys His Met Ser Ala Pro Leu Pro Gln Val 
                405                 410                 415     


Gly Ser Gly Glu Pro Val Glu Asp Leu Met Ala Val Leu Ser Gly Thr 
            420                 425                 430         


Asp Gly Ala Asp Ala Ala Ile Val Leu Val Glu Gly Lys Pro Lys Gly 
        435                 440                 445             


Val Val Ser Arg Gln Asp Leu Leu Ala Phe Leu Ala Glu Asp Ala Gly 
    450                 455                 460                 


Thr Ala Lys Ala 
465             


<210>  10
<211>  309
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  10

Met Gly Lys Ile Tyr Lys Asn Leu Ile Glu Thr Ile Gly Arg Thr Pro 
1               5                   10                  15      


Leu Val Glu Leu Ser Asn Tyr Lys Glu Lys Asn Lys Ile Glu Gly Asn 
            20                  25                  30          


Ile Leu Gly Lys Val Glu Tyr Phe Asn Pro Ser Gly Ser Ile Lys Asp 
        35                  40                  45              


Arg Ile Ala Tyr Ser Met Ile Lys Asn Ala Glu Glu Gln Gly Leu Ile 
    50                  55                  60                  


Asn Lys Asp Thr Val Ile Ile Glu Pro Thr Ser Gly Asn Thr Gly Val 
65                  70                  75                  80  


Gly Leu Ala Phe Ile Ala Ala Ala Lys Gly Tyr Lys Leu Val Leu Thr 
                85                  90                  95      


Met Pro Glu Thr Met Ser Val Glu Arg Arg Lys Leu Leu Thr Ala Tyr 
            100                 105                 110         


Gly Ala Glu Ile Val Leu Thr Ser Gly Val Glu Gly Met Thr Gly Ala 
        115                 120                 125             


Ile Lys Lys Ala Asn Glu Leu Ala Ser Glu Asn Pro Asn Ser Phe Ile 
    130                 135                 140                 


Pro Gln Gln Phe Lys Asn Pro Ser Asn Pro Ala Ile His Glu Val Thr 
145                 150                 155                 160 


Thr Gly Ile Glu Ile Trp Glu Asp Thr Asp Gly Lys Val Asp Ala Val 
                165                 170                 175     


Val Ala Gly Val Gly Thr Gly Gly Thr Ile Thr Gly Ile Ala Lys Thr 
            180                 185                 190         


Leu Arg Glu Lys Asn Lys Asp Ile Lys Ile Ile Ala Val Glu Pro Ala 
        195                 200                 205             


Thr Ser Pro Val Leu Ser Gly Gly Lys Ala Gly Pro His Lys Ile Gln 
    210                 215                 220                 


Gly Ile Gly Ala Gly Phe Val Pro Asp Val Tyr Glu Ala Glu Leu Ile 
225                 230                 235                 240 


Asp Glu Ile Ile Gln Val Lys Asn Glu Asp Ala Phe Ala Ser Ala Lys 
                245                 250                 255     


Glu Leu Ala Arg Glu Glu Gly Ile Leu Ala Gly Ile Ser Ser Gly Ala 
            260                 265                 270         


Ala Leu Phe Ala Ala Lys Glu Val Ala Ser Arg Pro Glu Phe Lys Gly 
        275                 280                 285             


Lys Asn Val Val Val Ile Leu Pro Asp Ser Gly Gln Arg Tyr Leu Ser 
    290                 295                 300                 


Met Ser Val Phe Asp 
305                 


<210>  11
<211>  421
<212>  PRT
<213>  Arabidopsis thaliana

<400>  11

Met Ala Pro Val Asn Met Thr Gly Ala Val Val Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Met Leu Thr Ser Tyr Ser Phe Phe Phe Arg Leu Ser Glu Lys Lys 
            20                  25                  30          


Lys Arg Lys Glu Lys Leu Thr Met Arg Asn Gly Leu Val Asp Ala Ile 
        35                  40                  45              


Gly Asn Thr Pro Leu Ile Arg Ile Asn Ser Leu Ser Glu Ala Thr Gly 
    50                  55                  60                  


Cys Glu Ile Leu Gly Lys Cys Glu Phe Leu Asn Pro Gly Gly Ser Val 
65                  70                  75                  80  


Lys Asp Arg Val Ala Val Lys Ile Ile Gln Glu Ala Leu Glu Ser Gly 
                85                  90                  95      


Lys Leu Phe Pro Gly Gly Ile Val Thr Glu Gly Ser Ala Gly Ser Thr 
            100                 105                 110         


Ala Ile Ser Leu Ala Thr Val Ala Pro Ala Tyr Gly Cys Lys Cys His 
        115                 120                 125             


Val Val Ile Pro Asp Asp Ala Ala Ile Glu Lys Ser Gln Ile Ile Glu 
    130                 135                 140                 


Ala Leu Gly Ala Ser Val Glu Arg Val Arg Pro Val Ser Ile Thr His 
145                 150                 155                 160 


Lys Asp His Tyr Val Asn Ile Ala Arg Arg Arg Ala Asp Glu Ala Asn 
                165                 170                 175     


Glu Leu Ala Ser Lys Arg Arg Leu Gly Ser Glu Thr Asn Gly Ile His 
            180                 185                 190         


Gln Glu Lys Thr Asn Gly Cys Thr Val Glu Glu Val Lys Glu Pro Ser 
        195                 200                 205             


Leu Phe Ser Asp Ser Val Thr Gly Gly Phe Phe Ala Asp Gln Phe Glu 
    210                 215                 220                 


Asn Leu Ala Asn Tyr Arg Ala His Tyr Glu Gly Thr Gly Pro Glu Ile 
225                 230                 235                 240 


Trp His Gln Thr Gln Gly Asn Ile Asp Ala Phe Val Ala Ala Ala Gly 
                245                 250                 255     


Thr Gly Gly Thr Leu Ala Gly Val Ser Arg Phe Leu Gln Asp Lys Asn 
            260                 265                 270         


Glu Arg Val Lys Cys Phe Leu Ile Asp Pro Pro Gly Ser Gly Leu Tyr 
        275                 280                 285             


Asn Lys Val Thr Arg Gly Val Met Tyr Thr Arg Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Arg Leu Lys Asn Pro Phe Asp Thr Ile Thr Glu Gly Ile Gly Ile 
305                 310                 315                 320 


Asn Arg Leu Thr Lys Asn Phe Leu Met Ala Lys Leu Asp Gly Gly Phe 
                325                 330                 335     


Arg Gly Thr Asp Lys Glu Ala Val Glu Met Ser Arg Phe Leu Leu Lys 
            340                 345                 350         


Asn Asp Gly Leu Phe Val Gly Ser Ser Ser Ala Met Asn Cys Val Gly 
        355                 360                 365             


Ala Val Arg Val Ala Gln Thr Leu Gly Pro Gly His Thr Ile Val Thr 
    370                 375                 380                 


Ile Leu Cys Asp Ser Gly Met Arg His Leu Ser Lys Phe His Asp Pro 
385                 390                 395                 400 


Lys Tyr Leu Asn Leu Tyr Gly Leu Ser Pro Thr Ala Ile Gly Leu Glu 
                405                 410                 415     


Phe Leu Gly Ile Lys 
            420     


<210>  12
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Gly Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Ile Thr Cys Gly 
            420                 425                 430         


His Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Ala Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Gly 
465                 470                 475                 480 


Lys Val Ile Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Arg Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Tyr His Ser Thr Gly Lys Ser Ser Gln Arg Gln 
        515                 520                 525             


Met Val Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala 
    530                 535                 540                 


Ala Gln Glu Arg Asp Gln Lys 
545                 550     


