                         SEQUENCE LISTING

<110>  ɽҽҩ޹˾
 
<120>  CTLA4-PD-1˫ܿ塢ҩＰ;

<130>  IEC170038PCT

<160>  47    

<170>  PatentIn version 3.2

<210>  1
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  4G10ɱĺ

<400>  1
caggtcaagc tgcaggagtc tggacctgag ctggtgaagc ctggagcttc aatgaagata     60

tcctgcaagg cttctggtta ctcattcact ggctacacca tgaactgggt gaagcagagc    120

catggaaaga accttgaatg gattggactt attaatcctt acaataatat tactaactac    180

aaccagaagt tcatgggcaa ggccacattt actgtagaca agtcatccag cacagcctac    240

atggaactcc tcagactgac atctgaagac tctggagtct atttctgtgc aagactcgac    300

tataggtctt attggggcca agggactctg gtcactgtct ctgcagccaa aacgacaccc    360

ccatctgtct at                                                        372


<210>  2
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  4G10ɱİ

<400>  2

Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Arg Leu Thr Ser Glu Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 


<210>  3
<211>  378
<212>  DNA
<213>  Artificial

<220>
<223>  4G10ɱĺ

<400>  3
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc     60

acttgtcgct caagtactgg ggctgttaca actagtaact ttgccaactg ggtccaagaa    120

aaaccagatc atttattcac tagtctaata ggtggtacca acaaccgagc tccaggtgtt    180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca    240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc    300

ggtggaggaa ccaaactgac tgtcctaggc cagcccaagt cttcgccatc agtcaccctg    360

tttcaagggc aattctgc                                                  378


<210>  4
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  4G10ɱİ

<400>  4

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Gln Gly Gln Phe Cys 
        115                 120                 125     


<210>  5
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H1L1ɱĺ

<400>  5
caggtgcagc tggtggagtc tggggccgag ctggtgaagc ccggcgcctc catgaagatc     60

tcttgcaagg ccagcggata cagtttcact ggctatacca tgaactgggt caaacaggct    120

ccaggacagg gactggagtg gatcgggctg attaatcctt acaacaacat caccaactac    180

aaccagaagt tcatgggaaa agcaaccttt acagtggaca agagcatttc cacagcctac    240

atggaactga gccggctgac ttcagacgat agcggggtct atttttgtgc aaggctggat    300

tatcgctctt actgggggca gggaactctg gtcactgtct ccgct                    345


<210>  6
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H1L1ɱİ

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  7
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H1L1ɱĺ

<400>  7
caggctgtcg tcactcagga accttcactg actgtgagcc caggaggaac tgtcaccctg     60

acatgcggaa gctccaccgg agcagtgacc acatccaact tcgccaattg ggtccaggaa    120

aagccaggcc aggcatttcg atccctgatc ggaggcacaa acaatcgggc ttcttgggtg    180

cccgcaagat tctcaggaag cctgctgggg ggaaaagccg ctctgaccat tagtggcgct    240

cagcctgagg acgaagccga gtacttctgc gctctgtggt atagcaacca ctgggtgttt    300

ggcgggggaa caaagctgac tgtgctg                                        327


<210>  8
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H1L1ɱİ

<400>  8

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Ser Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  9
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H3L3ɱĺ

<400>  9
caggtgcagc tggtcgagtc tggggccgaa gtgaagaaac ccggcgcctc agtgaaggtc     60

agctgcaagg ccagcgggta cagtttcact ggatatacca tgaactgggt ccgacaggcc    120

cctggccagg ggctggagtg gatcggcctg attaaccctt acaacaacat cactaactac    180

gcacagaagt tccaggggag agtgaccttt acagtggaca ccagcatttc cacagcctac    240

atggaactgt cccggctgag atctgacgat acaggcgtgt acttctgcgc taggctggat    300

taccgcagct attggggaca gggcacactg gtgactgtca gcgca                    345


<210>  10
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H3L3ɱİ

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  11
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H3L3ɱĺ

<400>  11
caggctgtcg tcactcagga accttcactg accgtgtctc ctggcgggac tgtcaccctg     60

acatgcggca gctccacagg ggccgtgacc acaagtaact tcccaaattg ggtccagcag    120

aagccaggac aggctccccg gagtctgatc ggaggcacca acaacaaggc cagctggaca    180

cccgcacggt tcagcggcag cctgctgggc ggcaaggccg ctctgacaat tagcggagcc    240

cagcctgagg acgaagccga gtactattgc gctctgtggt actccaacca ctgggtgttc    300

ggcggcggca ccaagctgac tgtgctg                                        327


<210>  12
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H3L3ɱİ

<400>  12

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Lys Ala Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  13
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H4L3ɱĺ

<400>  13
caggtgcagc tggtcgagtc tggggccgaa gtgaagaaac ccggcgcctc agtgaaggtc     60

agctgcaagg ccagcgggta cagtttcact ggatatacca tgaactgggt ccgacaggcc    120

cctggccagg ggctggagtg gatcggcctg attaaccctt acaacgacat cactaactac    180

gcacagaagt tccaggggag agtgaccttt acagtggaca ccagcatttc cacagcctac    240

atggaactgt cccggctgag atctgacgat acaggcgtgt acttctgcgc taggctggat    300

taccgcagct attggggaca gggcacactg gtgactgtca gcgca                    345


<210>  14
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H4L3ɱİ

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asp Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  15
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  14C12ɱĺ

<400>  15
gaggtcaaac tggtggagag cggcggcggg ctggtgaagc ccggcgggtc actgaaactg     60

agctgcgccg cttccggctt cgcctttagc tcctacgaca tgtcatgggt gaggcagacc    120

cctgagaagc gcctggaatg ggtcgctact atcagcggag gcgggcgata cacctactat    180

cctgactctg tcaaagggag attcacaatt agtcgggata acgccagaaa tactctgtat    240

ctgcagatgt ctagtctgcg gtccgaggat acagctctgt actattgtgc aaaccggtac    300

ggcgaagcat ggtttgccta ttggggacag ggcaccctgg tgacagtctc tgcc          354


<210>  16
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  14C12ɱİ

<400>  16

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  17
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  14C12ɱĺ

<400>  17
gacattaaga tgacacagtc cccttcctca atgtacgcta gcctgggcga gcgagtgacc     60

ttcacatgca aagcatccca ggacatcaac acatacctgt cttggtttca gcagaagcca    120

ggcaaaagcc ccaagaccct gatctaccgg gccaatagac tggtggacgg ggtccccagc    180

agattctccg gatctggcag tgggcaggat tactccctga ccatcagctc cctggagtat    240

gaagacatgg gcatctacta ttgcctgcag tatgatgagt tccctctgac ctttggagca    300

ggcacaaaac tggaactg                                                  318


<210>  18
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  14C12ɱİ

<400>  18

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105     


<210>  19
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  14C12H1L1ɱĺ

<400>  19
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg     60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca    120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat    180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat    240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac    300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagt          354


<210>  20
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1ɱİ

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  14C12H1L1ɱĺ

<400>  21
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc     60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca    120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt    180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct    240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc    300

gggacaaaac tggagctgaa g                                              321


<210>  22
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1ɱİ

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 2

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  25
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2ɱİ

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Ser Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Gln Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  26
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  8D2H14L2ɱĺ

<400>  26
gaggtgcagc tggtcgaatc tggaggagga ctggtgcagc ctggaggaag ctcccggctg     60

tcatgtgccg ctagcggctt caccttttcc gacaactgga tgaattgggt gcgacaggca    120

ccaggcaaag gactggagtg gctggctcag atccggaaca agccctacaa ttatgaaaca    180

tactatagcg cctccgtgaa aggccggttc actattagta gagacgattc taagaacagc    240

gtgtacctgc agatgaatag cctgaagaca gaggatactg gcgtctacta ttgcacagca    300

cagtttgcct attggggaca gggcaccctg gtgacagtct ctagt                    345


<210>  27
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2ɱİ

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Gly Gly 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Arg Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  8D2H14L2ɱĺ

<400>  28
gacatccaga tgactcagag cccctcaagc ctgtctgcaa gtgtgggcga tagggtcacc     60

atcacatgtc gcacctccga aaacatctac gggggactga attggtatca gcgcaagccc    120

ggcaaatccc ctaagctgct gatctacggc gctaccaacc tggcatctgg ggtgtcctct    180

cgattttcag ggagcggcag cggcaccgac tatactctga ccattagttc actgcagcct    240

gaggatgtgg ccacatacta ttgccagaat gtcctgagat caccattcac ttttgggagc    300

ggaaccaaac tggaaattaa g                                              321


<210>  29
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  14C12HCDR1

<400>  29

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  14C12HCDR2

<400>  30

Ile Ser Gly Gly Gly Arg Tyr Thr 
1               5               


<210>  31
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  14C12HCDR3

<400>  31

Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  32
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  14C12LCDR1

<400>  32

Gln Asp Ile Asn Thr Tyr 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  14C12LCDR2

<400>  33

Arg Ala Asn 
1           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  14C12LCDR3

<400>  34

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  4G10HCDR1

<400>  35

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  4G10HCR2

<400>  36

Ile Asn Pro Tyr Asn Asn Ile Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  4G10HCDR3

<400>  37

Ala Arg Leu Asp Tyr Arg Ser Tyr 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  4G10LCDR1

<400>  38

Thr Gly Ala Val Thr Thr Ser Asn Phe 
1               5                   


<210>  39
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  4G10LCDR2

<400>  39

Gly Thr Asn 
1           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  4G10LCDR3

<400>  40

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H4L3HCDR2

<400>  41

Ile Asn Pro Tyr Asn Asp Ile Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2HCDR1

<400>  42

Gly Phe Thr Phe Ser Asp Asn Trp 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2HCDR2

<400>  43

Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr 
1               5                   10  


<210>  44
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2HCDR3

<400>  44

Thr Ala Gln Phe Ala Tyr 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2LCDR1

<400>  45

Glu Asn Ile Tyr Gly Gly 
1               5       


<210>  46
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2LCDR2

<400>  46

Gly Ala Thr 
1           


<210>  47
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  8D2H14L2LCDR3

<400>  47

Gln Asn Val Leu Arg Ser Pro Phe Thr Phe 
1               5                   10  


