                         SEQUENCE LISTING

<110>  ImmuneXpress Pty Ltd
 
<120>  Systemic inflammatory and pathogen biomarkers and uses therefor

<130>  35271034/VPA

<150>  2016903370
<151>  2016-08-24

<160>  1576  

<170>  PatentIn version 3.5

<210>  1
<211>  2757
<212>  DNA
<213>  Homo sapiens;

<400>  1
atgccagggg gcgcaggcgc cgcccggctc tgcttgctgg cgtttgccct gcagcccctc       60

cggccgcggg cggcgcggga gcctggatgg acaagaggaa gtgaggaagg cagccccaag      120

ctgcagcatg aacttatcat acctcagtgg aagacttcag aaagccccgt gagagaaaag      180

catccactca aagctgagct cagggtaatg gctgaggggc gagaactgat cctggacctg      240

gagaagaatg agcaactttt tgctccttcc tacacagaaa cccattatac ttcaagtggt      300

aaccctcaaa ccaccacacg gaaattggag gatcactgct tttaccacgg cacggtgagg      360

gagacagaac tgtccagcgt cacgctcagc acttgccgag gaattagagg actgattacg      420

gtgagcagca acctcagcta cgtcatcgag cccctccctg acagcaaggg ccaacacctt      480

atttacagat ctgaacatct caagccgccc ccgggaaact gtgggttcga gcactccaag      540

cccaccacca gggactgggc tcttcagttt acacaacaga ccaagaagcg acctcgcagg      600

atgaaaaggg aagatttaaa ctccatgaag tatgtggagc tttacctcgt ggctgattat      660

ttagagtttc agaagaatcg acgagaccag gacgccacca aacacaagct catagagatc      720

gccaactatg ttgataagtt ttaccgatcc ttgaacatcc ggattgctct cgtgggcttg      780

gaagtgtgga cccacgggaa catgtgtgaa gtttcagaga atccatattc taccctctgg      840

tcctttctca gttggaggcg caagctgctt gcccagaagt accatgacaa cgcccaatta      900

atcacgggca tgtccttcca cggcaccacc atcggcctgg cccccctcat ggccatgtgc      960

tctgtgtacc agtctggagg agtcaacatg gaccactccg agaatgccat tggcgtggct     1020

gccaccatgg cccacgagat gggccacaac tttggcatga cccatgattc tgcagattgc     1080

tgctcggcca gtgcggctga tggtgggtgc atcatggcag ctgccactgg gcaccccttt     1140

cccaaagtgt tcaatggatg caacaggagg gagctggaca ggtatctgca gtcaggtggt     1200

ggaatgtgtc tctccaacat gccagacacc aggatgttgt atggaggccg gaggtgtggg     1260

aacgggtatc tggaagatgg ggaagagtgt gactgtggag aagaagagga atgtaacaac     1320

ccctgctgca atgcctctaa ttgtaccctg aggccggggg cggagtgtgc tcacggctcc     1380

tgctgccacc agtgtaagct gttggctcct gggaccctgt gccgcgagca ggccaggcag     1440

tgtgacctcc cggagttctg tacgggcaag tctccccact gccctaccaa cttctaccag     1500

atggatggta ccccctgtga gggcggccag gcctactgct acaacggcat gtgcctcacc     1560

taccaggagc agtgccagca gctgtgggga cccggagccc gacctgcccc tgacctctgc     1620

ttcgagaagg tgaatgtggc aggagacacc tttggaaact gtggaaagga catgaatggt     1680

gaacacagga agtgcaacat gagagatgcg aagtgtggga agatccagtg tcagagctct     1740

gaggcccggc ccctggagtc caacgcggtg cccattgaca ccactatcat catgaatggg     1800

aggcagatcc agtgccgggg cacccacgtc taccgaggtc ctgaggagga gggtgacatg     1860

ctggacccag ggctggtgat gactggaacc aagtgtggct acaaccatat ttgctttgag     1920

gggcagtgca ggaacacctc cttctttgaa actgaaggct gtgggaagaa gtgcaatggc     1980

catggggtct gtaacaacaa ccagaactgc cactgcctgc cgggctgggc cccgcccttc     2040

tgcaacacac cgggccacgg gggcagtatc gacagtgggc ctatgccccc tgagagtgtg     2100

ggtcctgtgg tagctggagt gttggtggcc atcttggtgc tggcggtcct catgctgatg     2160

tactactgct gcagacagaa caacaaacta ggccaactca agccctcagc tctcccttcc     2220

aagctgaggc aacagttcag ttgtcccttc agggtttctc agaacagcgg gactggtcat     2280

gccaacccaa ctttcaagct gcagacgccc cagggcaagc gaaaggtgat caacactccg     2340

gaaatcctgc ggaagccctc ccagcctcct ccccggcccc ctccagatta tctgcgtggt     2400

gggtccccac ctgcaccact gccagctcac ctgagcaggg ctgctaggaa ctccccaggg     2460

cccgggtctc aaatagagag gacggagtcg tccaggaggc ctcctccaag ccggccaatt     2520

ccccccgcac caaattgcat cgtttcccag gacttctcca ggcctcggcc gccccagaag     2580

gcactcccgg caaacccagt gccaggccgc aggagcctcc ccaggccagg aggtgcatcc     2640

ccactgcggc cccctggtgc tggccctcag cagtcccggc ctctggcagc acttgcccca     2700

aagtttccag aatacagatc acagagggct ggagggatga ttagctcgaa aatctag        2757


<210>  2
<211>  558
<212>  DNA
<213>  Homo sapiens;

<400>  2
atgaagctgg tttccgtcgc cctgatgtac ctgggttcgc tcgccttcct aggcgctgac       60

accgctcggt tggatgtcgc gtcggagttt cgaaagaagt ggaataagtg ggctctgagt      120

cgtgggaaga gggaactgcg gatgtccagc agctacccca ccgggctcgc tgacgtgaag      180

gccgggcctg cccagaccct tattcggccc caggacatga agggtgcctc tcgaagcccc      240

gaagacagca gtccggatgc cgcccgcatc cgagtcaagc gctaccgcca gagcatgaac      300

aacttccagg gcctccggag ctttggctgc cgcttcggga cgtgcacggt gcagaagctg      360

gcacaccaga tctaccagtt cacagataag gacaaggaca acgtcgcccc caggagcaag      420

atcagccccc agggctacgg ccgccggcgc cggcgctccc tgcccgaggc cggcccgggt      480

cggactctgg tgtcttctaa gccacaagca cacggggctc cagccccccc gagtggaagt      540

gctccccact ttctttag                                                    558


<210>  3
<211>  1575
<212>  DNA
<213>  Homo sapiens;

<400>  3
atgatttcac cattcttagt actggccatt ggcacctgcc ttactaactc cttagtgcca       60

gagaaagaga aagaccccaa gtactggcga gaccaagcgc aagagacact gaaatatgcc      120

ctggagcttc agaagctcaa caccaacgtg gctaagaatg tcatcatgtt cctgggagat      180

gggatgggtg tctccacagt gacggctgcc cgcatcctca agggtcagct ccaccacaac      240

cctggggagg agaccaggct ggagatggac aagttcccct tcgtggccct ctccaagacg      300

tacaacacca atgcccaggt ccctgacagt gccggcaccg ccaccgccta cctgtgtggg      360

gtgaaggcca atgagggcac cgtgggggta agcgcagcca ctgagcgttc ccggtgcaac      420

accacccagg ggaacgaggt cacctccatc ctgcgctggg ccaaggacgc tgggaaatct      480

gtgggcattg tgaccaccac gagagtgaac catgccaccc ccagcgccgc ctacgcccac      540

tcggctgacc gggactggta ctcagacaac gagatgcccc ctgaggcctt gagccagggc      600

tgtaaggaca tcgcctacca gctcatgcat aacatcaggg acattgacgt gatcatgggg      660

ggtggccgga aatacatgta ccccaagaat aaaactgatg tggagtatga gagtgacgag      720

aaagccaggg gcacgaggct ggacggcctg gacctcgttg acacctggaa gagcttcaaa      780

ccgagataca agcactccca cttcatctgg aaccgcacgg aactcctgac ccttgacccc      840

cacaatgtgg actacctatt gggtctcttc gagccagggg acatgcagta cgagctgaac      900

aggaacaacg tgacggaccc gtcactctcc gagatggtgg tggtggccat ccagatcctg      960

cggaagaacc ccaaaggctt cttcttgctg gtggaaggag gcagaattga ccacgggcac     1020

catgaaggaa aagccaagca ggccctgcat gaggcggtgg agatggaccg ggccatcggg     1080

caggcaggca gcttgacctc ctcggaagac actctgaccg tggtcactgc ggaccattcc     1140

cacgtcttca catttggtgg atacaccccc cgtggcaact ctatctttgg tctggccccc     1200

atgctgagtg acacagacaa gaagcccttc actgccatcc tgtatggcaa tgggcctggc     1260

tacaaggtgg tgggcggtga acgagagaat gtctccatgg tggactatgc tcacaacaac     1320

taccaggcgc agtctgctgt gcccctgcgc cacgagaccc acggcgggga ggacgtggcc     1380

gtcttctcca agggccccat ggcgcacctg ctgcacggcg tccacgagca gaactacgtc     1440

ccccacgtga tggcgtatgc agcctgcatc ggggccaacc tcggccactg tgctcctgcc     1500

agctcggcag gcagccttgc tgcaggcccc ctgctgctcg cgctggccct ctaccccctg     1560

agcgtcctgt tctga                                                      1575


<210>  4
<211>  1074
<212>  DNA
<213>  Homo sapiens;

<400>  4
atggcccggg agaacggcga gagcagctcc tcctggaaaa agcaagctga agacatcaag       60

aagatcttcg agttcaaaga gaccctcgga accggggcct tttccgaagt ggttttagct      120

gaagagaagg caactggcaa gctctttgct gtgaagtgta tccctaagaa ggcgctgaag      180

ggcaaggaaa gcagcataga gaatgagata gccgtcctga gaaagattaa gcatgaaaat      240

attgttgccc tggaagacat ttatgaaagc ccaaatcacc tgtacttggt catgcagctg      300

gtgtccggtg gagagctgtt tgaccggata gtggagaagg ggttttatac agagaaggat      360

gccagcactc tgatccgcca agtcttggac gccgtgtact atctccacag aatgggcatc      420

gtccacagag acctcaagcc cgaaaatctc ttgtactaca gtcaagatga ggagtccaaa      480

ataatgatca gtgactttgg attgtcaaaa atggagggca aaggagatgt gatgtccact      540

gcctgtggaa ctccaggcta tgtcgctcct gaagtcctcg cccagaaacc ttacagcaaa      600

gccgttgact gctggtccat cggagtgatt gcctacatct tgctctgcgg ctaccctcct      660

ttttatgatg aaaatgactc caagctcttt gagcagatcc tcaaggcgga atatgagttt      720

gactctccct actgggatga catctccgac tctgcaaaag acttcattcg gaacctgatg      780

gagaaggacc cgaataaaag atacacgtgt gagcaggcag ctcggcaccc atggatcgct      840

ggtgacacag ccctcaacaa aaacatccac gagtccgtca gcgcccagat ccggaaaaac      900

tttgccaaga gcaaatggag acaagcattt aatgccacgg ccgtcgtcag acatatgaga      960

aaactacacc tcggcagcag cctggacagt tcaaatgcaa gtgtttcgag cagcctcagt     1020

ttggccagcc aaaaagactg tgcgtatgta gcaaaaccag aatccctcag ctga           1074


<210>  5
<211>  2361
<212>  DNA
<213>  Homo sapiens;

<400>  5
atgaagggaa caggcatcat ggactgtgcg cccaaggcac tcctggccag ggcactttat       60

gacaactgcc ctgactgctc tgacgagctg gctttcagca gaggggacat cctgaccatt      120

ctggagcaac acgtgccaga aagcgagggt tggtggaagt gtttgctcca tgggaggcaa      180

ggcctggccc ctgccaaccg cctccaaatc ctcacggagg tcgctgcaga caggccgtgc      240

cccccattcc tgagaggcct ggaagaagct cctgccagct cagaggagac ctatcaggtg      300

cccactctac cccgccctcc cactccaggc cccgtttatg agcagatgag gagttgggcg      360

gaggggcccc agccccctac tgcccaagtc tatgaattcc ccgaccctcc caccagtgcc      420

agaatcatct gtgaaaagac tctcagcttt ccaaaacagg ccatcctcac gcttcccaga      480

cctgtccggg cctcactgcc gactctgcct tcccaggtgt atgacgtgcc tacccagcac      540

cggggccccg tggtcctgaa ggagccagag aagcagcagt tatatgacat accagccagc      600

cccaagaagg caggactcca tcccccagac agccaagcaa gtgggcaggg tgttcccctg      660

atatcagtga ctaccttaag aagaggcggt tacagcacat taccaaatcc tcagaaatcg      720

gaatggattt atgacactcc agtgtctcca ggaaaggcca gcgtcagaaa cacgcctctc      780

accagctttg cggaagaatc aaggccccac gctctcccca gttccagctc cactttctac      840

aatcctccaa gtggcagatc caggtccctc actccacaac tgaataacaa tgtgcccatg      900

cagaaaaaac tcagccttcc agaaattcct tcttatggct ttcttgtacc cagaggcaca      960

tttcctttgg atgaagatgt cagctacaag gttccttcaa gctttctgat tccccgagtg     1020

gaacagcaga acaccaagcc caatatttat gacatcccta aagcaacgtc gagtgtttct     1080

caggctggga aggagctgga gaaagccaag gaggtgtcag agaattccgc gggccataat     1140

tcctcatggt tctccagacg gacaacttcc ccatctcctg aaccggacag attatcaggt     1200

tccagttctg acagcagagc tagcatcgtt tcctcgtgct ccaccacatc caccgacgac     1260

tcctccagct cttcctcgga ggagtcagca aaggagctct ccttggacct ggatgtggcc     1320

aaggagacag tgatggctct gcagcacaag gtggtcagct ctgtcgctgg cctgatgctc     1380

tttgtcagca ggaagtggag attccgagac tatctggagg ccaacattga tgcaatccac     1440

aggtccactg atcacataga agaatctgta agagaatttc tggattttgc ccgaggagtc     1500

catgggactg cctgtaacct cactgacagt aaccttcaga acagaattcg ggaccagatg     1560

cagaccatct ccaactccta ccgcatcctg cttgaaacaa aggaaagctt ggataatcgc     1620

aattggcctc tggaagttct tgtgactgac agtgtccaga acagcccaga tgaccttgag     1680

aggtttgtca tggtggcacg gatgcttcca gaagacatca agaggtttgc ctccattgtc     1740

attgccaatg gaaggctcct ttttaagcgg aactgtgaaa aggaagagac tgtgcagttg     1800

accccaaatg cagaatttaa gtgtgaaaaa tacatccagc ctccccaaag agaaactgaa     1860

tcacaccaaa agagtacccc ttccactaag caaagggaag atgaacactc ttctgaacta     1920

ttaaagaaaa atagggcaaa tatctgtgga cagaatcctg gccctcttat acctcagcct     1980

tcgagtcaac agactcctga gaggaaaccc cgcttatctg aacactgccg gctctacttt     2040

ggggcgctct tcaaagccat cagcgcattt cacggcagcc tcagcagcag ccagcccgcg     2100

gagatcatca ctcagagcaa gctggtcatc atggtgggac agaagctggt ggacacgctg     2160

tgcatggaga cccaggagag ggacgtgcgc aacgagatcc tccgtggcag cagtcacctc     2220

tgcagcctgc tcaaggacgt agcgctggcc actaagaatg ccgtgctcac gtaccccagc     2280

cctgccgcgc tggggcacct ccaggcggag gctgagaagc tggagcaaca cacgcggcag     2340

ttcagaggga cactgggatg a                                               2361


<210>  6
<211>  1476
<212>  DNA
<213>  Homo sapiens;

<400>  6
atggatcaca ctgacaatga gttacaaggc actaatagtt ctggatcctt gggtggtctt       60

gatgttcgca gacgaattcc tataaagctc atctccaaac aagcaaacaa agcgaaacct      120

gcaccgcgaa ctcaaagaac tataaacagg atgcctgcaa aggctccacc tggtgatgaa      180

gaaggatttg attataatga agaagaacgg tatgactgta aagggggtga gctgtttgca      240

aatcagcgaa gatttcctgg acaccttttt tgggactttc agataaacat cttaggtgaa      300

aaggatgata caccagttca tttctgtgac aagtgtggat tgcctattaa aatctatggg      360

agaatgattc catgcaagca tgttttttgc tatgactgtg ctattttaca tgaaaaaaag      420

ggagataaga tgtgtccagg ctgtagtgat cctgtgcagc gaattgagca gtgtacacga      480

ggttctctct tcatgtgtag cattgttcaa gggtgcaaga gaacatattt gtctcagaga      540

gacttacagg ctcatatcaa ccatcgccat atgagagctg gaaaacctgt tacccgtgct      600

tcacttgaaa atgttcatcc tcctattgcc ccaccaccaa ctgaaatccc tgagcgtttt      660

ataatgccac cagacaagca ccatatgagc catattccgc caaagcagca catcatgatg      720

ccaccacctc ctttgcaaca tgtgccacat gagcactata atcagccaca tgaggatatt      780

cgtgctcctc cagcagaatt gtccatggct ccacctccac ctcgatcggt cagtcaggaa      840

acctttcgta tttcaacaag aaaacacagc aatttaataa ccgtccctat tcaggatgac      900

tcaaattcag gtgctagaga accaccacct cctgccccag cacctgctca ccatcatcct      960

gaatatcagg gtcaaccagt ggtatcgcac cctcatcata ttatgcctcc acagcaacat     1020

tatgcaccac ccccacctcc tccaccacca ataagccatc caatgccaca tcctccccag     1080

gctgcaggta ctcctcactt ggtatatagc caagctccac ctccaccaat gacctctgct     1140

ccaccaccaa taacccctcc ccctggacat attattgccc agatgccacc ttatatgaat     1200

catcctcctc caggacctcc cccacctcaa catggtggtc cacctgtaac tgcaccccct     1260

cctcaccatt ataatcctaa ctcattaccc cagttcactg aagatcaagg aactctgagc     1320

cctccattta cacaaccagg gggaatgagt cctggtatat ggcctgcacc aagagggcca     1380

ccaccacctc cacgattgca gggtccgcct tctcaaaccc cacttcctgg accacatcat     1440

ccagatcaga caagatatag accgtattac caatga                               1476


<210>  7
<211>  1743
<212>  DNA
<213>  Homo sapiens;

<400>  7
atgaaggaga ataaagaaaa ttcaagccct tcagtaactt cagcaaacct ggaccacaca       60

aagccatgtt ggtactggga taagaaagac ttggctcata caccctcaca acttgaagga      120

cttgatccag ccaccgaggc ccggtaccgc cgagagggcg ctcggttcat ctttgatgtg      180

ggcacacgtt tggggctaca ctatgatacc ctggcaactg gaataattta ttttcatcgc      240

ttctatatgt ttcattcctt caagcaattc ccaagatatg tgacaggagc ctgttgcctc      300

tttctggctg ggaaagtaga agaaacacca aaaaaatgta aagatatcat caaaacagct      360

cgtagtttat taaatgatgt acaatttggc cagtttggag atgacccaaa ggaggaagta      420

atggttctgg agagaatctt actgcagacc atcaagtttg atttacaggt agaacatcca      480

taccagttcc tactaaaata tgcaaagcaa ctcaaaggtg ataaaaacaa aattcaaaag      540

ttggttcaaa tggcatggac atttgtaaat gacagtctct gcaccacctt gtcactgcag      600

tgggaaccag agatcatagc agtagcagtg atgtatctcg caggacgttt gtgcaaattt      660

gaaatacaag aatggacctc caaacccatg tataggagat ggtgggagca gtttgttcaa      720

gatgtcccgg tcgacgtttt ggaagacatc tgccaccaaa tcctggatct ttactcacaa      780

ggaaaacaac agatgcctca tcacaccccc catcagctgc aacagccccc atctcttcag      840

cctacaccac aagtgccgca agtacagcag tcacagccgt ctcaaagctc cgaaccatcc      900

cagccccagc agaaggaccc ccagcaacca gcccagcagc agcagccagc ccaacagccc      960

aagaaaccct ctccgcagcc cagttctccc cgacaggtta agcgagccgt ggttgtttct     1020

cccaaagaag agaacaaagc agcagaacca ccaccaccta aaatccccaa aattgagacc     1080

actcatccac cgttgcctcc agcccaccca cctccagacc ggaagcctcc cctcgctgct     1140

gccttaggtg aggctgagcc gccgggccct gtggatgcca ctgacctccc caaagtccag     1200

attccccctc cggcccaccc ggcccctgtg caccagccac cgccgctgcc acaccggccc     1260

ccgcccccac ccccctccag ctacatgacc gggatgtcca ccaccagctc ctacatgtct     1320

ggagagggct accagagcct gcagtccatg atgaagaccg agggaccctc ctacggtgcc     1380

ctgccccccg cctacggccc acctgcacac ctgccctacc acccccatgt ctacccgccc     1440

aacccgcccc cgccacctgt gcctcctccc ccagcctcct tccccccacc tgccatccca     1500

ccccctactc ctggctaccc cccaccccca cccacctaca accccaactt cccaccccca     1560

cccccacgcc tcccgcctac ccacgcagtc ccccctcatc ctcctccagg gttgggcctg     1620

ccgccagcca gctacccacc tcctgccgtc ccccctggag gacagcctcc tgtgcccccg     1680

cccattcccc cacccggcat gcctccagtt ggggggctgg ggcgggcagc ctggatgaga     1740

taa                                                                   1743


<210>  8
<211>  804
<212>  DNA
<213>  Homo sapiens;

<400>  8
atgggctcag cctgtatcaa agtcaccaaa tactttctct tcctcttcaa cttgatcttc       60

tttatcctgg gcgcagtgat cctgggcttc ggggtgtgga tcctggccga caagagcagt      120

ttcatctctg tcctgcaaac ctcctccagc tcgcttagga tgggggccta tgtcttcatc      180

ggcgtggggg cagtcactat gctcatgggc ttcctgggct gcatcggcgc cgtcaacgag      240

gtccgctgcc tgctggggct gtactttgct ttcctgctcc tgatcctcat tgcccaggtg      300

acggccgggg ccctcttcta cttcaacatg ggcaagctga agcaggagat gggcggcatc      360

gtgactgagc tcattcgaga ctacaacagc agtcgcgagg acagcctgca ggatgcctgg      420

gactacgtgc aggctcaggt gaagtgctgc ggctgggtca gcttctacaa ctggacagac      480

aacgctgagc tcatgaatcg ccctgaggtc acctacccct gttcctgcga agtcaagggg      540

gaagaggaca acagcctttc tgtgaggaag ggcttctgcg aggcccccgg caacaggacc      600

cagagtggca accaccctga ggactggcct gtgtaccagg agggctgcat ggagaaggtg      660

caggcgtggc tgcaggagaa cctgggcatc atcctcggcg tgggcgtggg tgtggccatc      720

atcgagctcc tggggatggt cctgtccatc tgcttgtgcc ggcacgtcca ttccgaagac      780

tacagcaagg tccccaagta ctga                                             804


<210>  9
<211>  606
<212>  DNA
<213>  Homo sapiens;

<400>  9
atggaatatc atcctgattt agaaaatttg gatgaagatg gatatactca attacacttc       60

gactctcaaa gcaataccag gatagctgtt gtttcagaga aaggatcgtg tgctgcatct      120

cctccttggc gcctcattgc tgtaattttg ggaatcctat gcttggtaat actggtgata      180

gctgtggtcc tgggtaccat gggggttctt tccagccctt gtcctcctaa ttggattata      240

tatgagaaga gctgttatct attcagcatg tcactaaatt cctgggatgg aagtaaaaga      300

caatgctggc aactgggctc taatctccta aagatagaca gctcaaatga attgggattt      360

atagtaaaac aagtgtcttc ccaacctgat aattcatttt ggataggcct ttctcggccc      420

cagactgagg taccatggct ctgggaggat ggatcaacat tctcttctaa cttatttcag      480

atcagaacca cagctaccca agaaaaccca tctccaaatt gtgtatggat tcacgtgtca      540

gtcatttatg accaactgtg tagtgtgccc tcatatagta tttgtgagaa gaagttttca      600

atgtaa                                                                 606


<210>  10
<211>  2124
<212>  DNA
<213>  Homo sapiens;

<400>  10
atggcggcgg cggtagctgc ggcgggtcgg ttaggctggt tgttcgccgc gctctgcctg       60

ggcaacgccg cgggggaggc cgcgccgggc ccgcgagtgc tgggcttctg cctggaggag      120

gatggagcgg cgggcgcggg ttgggtacgc ggaggggcgg cgcgggacac gccggacgcc      180

accttcctcc tgcgcctctt cggcccgggc ttcgccaaca gctcttggtc ctgggtggcc      240

ccggaggggg cgggctgccg ggaggaggcg gcctcccccg cgggcgagtg gcgcgcgctg      300

ctgcgcttgc gcctgcgggc cgaggccgtg cgcccgcact cggcgctgct ggcggtgcgc      360

gtggagccgg gtggcggggc ggctgaggag gcggcgccgc cctgggctct gggcctgggg      420

gcggccgggc tgctggcgct ggcagcgctg gcgcgaggcc tgcagctgag cgcgctggcg      480

ctggcgcctg ccgaggtgca ggtgctgcgc gagagcggct cggaggcgga gcgtgcggcg      540

gcgcggcgtt tggagcccgc gcggcgctgg gccggctgcg ccttgggcgc gctgctgctg      600

ctggccagcc tggcgcaggc ggcgctggcg gtgctgctgt accgcgcggc cggccagcgt      660

gcggtgcccg ccgtgttggg cagcgcgggg ctcgtgttcc tggtgggaga ggtggtgccg      720

gccgccgtga gcgggcgctg gacgctggcg ctggcgccgc gagcgctcgg cctcagccgc      780

ctggccgtcc tgctcactct gcccgtcgcg ctgcccgtgg ggcagctgct ggagctggcg      840

gcgcggcccg ggcggctgcg ggagcgggtg ctggagctgg cgcgcggcgg cggcgacccc      900

tacagcgatc tcagcaaggg cgtgctgcgc tgccggaccg tggaggacgt gctcacgccc      960

ctcgaagact gcttcatgct ggacgccagc accgtgctgg acttcggcgt cctggccagc     1020

atcatgcaga gcggccacac gcgcatcccg gtgtacgagg aggagcgctc caacatcgtg     1080

gacatgctct acctcaagga cttggccttc gtggatcccg aagactgcac gccgctcagc     1140

accatcactc gtttctacaa ccatccgctc cacttcgtct tcaacgacac caagctggac     1200

gctgtcctgg aggaattcaa gcgagggaag tcccacctgg ccatcgtgca gaaggtgaac     1260

aacgagggtg aaggcgaccc cttctacgag gtcctgggcc tggtcaccct ggaggacgtg     1320

atcgaggaga tcatcaggtc cgagatcctg gacgagtctg aagactaccg agacaccgtg     1380

gtgaagagga agcctgcttc tctgatggcc cctctgaagc ggaaggagga gttctccttg     1440

ttcaaggtgt ctgatgatga atataaagta acaatctcgc ctcagctgct cttggccacc     1500

cagcgcttcc tgtcccgaga agtggatgta ttcagcccgc tgcgcatctc tgagaaggtc     1560

ctgctgcacc tgttgaagca tcccagtgtc aaccaggaag tgaggtttga cgagagcaac     1620

cggctggcca cacaccacta cctgtaccag cgcagccagc cggtggatta cttcattctc     1680

atcctgcagg gcagggttga agtggagatc gggaaagagg gtctgaagtt tgagaatggg     1740

gccttcacgt actatggagt gtcggcccta actgtgccat cctcggttca ccagtccccg     1800

gtgtcctcgc tccagcccat ccgccatgac ctgcagcccg acccaggtga cggcacgcat     1860

tcatctgcgt attgtcccga ctacaccgtg agggcgctct ctgatctgca gctcatcaag     1920

gttacgcgac tgcagtacct caatgcactc ctggctaccc gagcccagaa cctgccacag     1980

tcccctgaga acaccgacct gcaggttatt ccaggcagcc agaccaggct ccttggtgag     2040

aagaccacca cagcggcagg gtccagccac agcaggcccg gcgtcccggt ggaaggcagc     2100

cctgggcgga acccaggcgt ttaa                                            2124


<210>  11
<211>  1167
<212>  DNA
<213>  Homo sapiens;

<400>  11
atgcagcgat tgctctttcc gccgttgagg gccttgaagg ggaggcagta tctgccgctc       60

ctggctccta gggcagcgcc tagagcacag tgtgattgca tcaggcgccc tttgaggcca      120

gggcaataca gcaccatctc tgaagtagct ttgcaatctg gaaggggtac agtgtccctt      180

ccctcaaagg ctgctgagcg ggtggtgggc cgatggctcc tggtctgcag tggaacagtg      240

gctggagcag ttattcttgg tggagtaact aggttgacag agtctggcct ctcgatggta      300

gattggcatt taataaagga gatgaagcca cctacaagcc aagaggaatg ggaagcagaa      360

ttccaaagat accagcaatt tccagaattt aaaatcttga atcatgatat gacactgaca      420

gaattcaagt tcatctggta catggagtac tcacaccgaa tgtggggtcg ccttgtaggc      480

cttgtgtaca tcctgcctgc tgcctacttt tggagaaagg gctggctcag ccgtggcatg      540

aaaggacgtg ttcttgccct ctgtggcctc gtctgcttcc agggtctgtt gggatggtat      600

atggtgaaaa gtggactaga agaaaaatca gactcccatg acatccctcg ggtcagtcag      660

taccgccttg ctgcccacct gggatcagcc ctggttcttt attgtgccag cttgtggacc      720

tcactgtcac tgctactccc tccgcacaag ttgcctgaaa cccaccaact cctacagttg      780

agacgatttg ctcatggaac agcaggtctg gtgttcctta cggccctctc aggggctttt      840

gtggcagggc tagatgctgg gcttgtttat aactcctttc ccaaaatggg agaatcctgg      900

atcccggagg acctctttac cttctccccc atcctgagga atgtttttga gaatcccacc      960

atggtgcagt ttgatcaccg gattctggga atcacttcag tcactgccat tacagtgctc     1020

tacttcctct ctcggagaat tccccttcct agaaggacca agatggcagc agtgactctg     1080

ctggctttgg cgtatacaca gggccctgtc ttattcaact ttacttttaa aatcagtgat     1140

ttggatgaag gcatcagaaa catctga                                         1167


<210>  12
<211>  6120
<212>  DNA
<213>  Homo sapiens;

<400>  12
atgggggcct cttctccaag aagcccggag cctgtcgggc cgccggcgcc cggtctcccc       60

ttctgctgcg gaggatccct gctggcggtt gtggtgctgc ttgcgctgcc ggtggcctgg      120

ggtcaatgca atgccccaga atggcttcca tttgccaggc ctaccaacct aactgatgaa      180

tttgagtttc ccattgggac atatctgaac tatgaatgcc gccctggtta ttccggaaga      240

ccgttttcta tcatctgcct aaaaaactca gtctggactg gtgctaagga caggtgcaga      300

cgtaaatcat gtcgtaatcc tccagatcct gtgaatggca tggtgcatgt gatcaaaggc      360

atccagttcg gatcccaaat taaatattct tgtactaaag gataccgact cattggttcc      420

tcgtctgcca catgcatcat ctcaggtgat actgtcattt gggataatga aacacctatt      480

tgtgacagaa ttccttgtgg gctacccccc accatcacca atggagattt cattagcacc      540

aacagagaga attttcacta tggatcagtg gtgacctacc gctgcaatcc tggaagcgga      600

gggagaaagg tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat      660

caagtgggca tctggagcgg ccccgcccct cagtgcatta tacctaacaa atgcacgcct      720

ccaaatgtgg aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa      780

gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc      840

caggccctga acaaatggga gccggagcta ccaagctgct ccagggtatg tcagccacct      900

ccagatgtcc tgcatgctga gcgtacccaa agggacaagg acaacttttc acctgggcag      960

gaagtgttct acagctgtga gcccggctac gacctcagag gggctgcgtc tatgcgctgc     1020

acaccccagg gagactggag ccctgcagcc cccacatgtg aagtgaaatc ctgtgatgac     1080

ttcatgggcc aacttcttaa tggccgtgtg ctatttccag taaatctcca gcttggagca     1140

aaagtggatt ttgtttgtga tgaaggattt caattaaaag gcagctctgc tagttactgt     1200

gtcttggctg gaatggaaag cctttggaat agcagtgttc cagtgtgtga acaaatcttt     1260

tgtccaagtc ctccagttat tcctaatggg agacacacag gaaaacctct ggaagtcttt     1320

ccctttggga aaacagtaaa ttacacatgc gacccccacc cagacagagg gacgagcttc     1380

gacctcattg gagagagcac catccgctgc acaagtgacc ctcaagggaa tggggtttgg     1440

agcagccctg cccctcgctg tggaattctg ggtcactgtc aagccccaga tcattttctg     1500

tttgccaagt tgaaaaccca aaccaatgca tctgactttc ccattgggac atctttaaag     1560

tacgaatgcc gtcctgagta ctacgggagg ccattctcta tcacatgtct agataacctg     1620

gtctggtcaa gtcccaaaga tgtctgtaaa cgtaaatcat gtaaaactcc tccagatcca     1680

gtgaatggca tggtgcatgt gatcacagac atccaggttg gatccagaat caactattct     1740

tgtactacag ggcaccgact cattggtcac tcatctgctg aatgtatcct ctcgggcaat     1800

gctgcccatt ggagcacgaa gccgccaatt tgtcaacgaa ttccttgtgg gctacccccc     1860

accatcgcca atggagattt cattagcacc aacagagaga attttcacta tggatcagtg     1920

gtgacctacc gctgcaatcc tggaagcgga gggagaaagg tgtttgagct tgtgggtgag     1980

ccctccatat actgcaccag caatgacgat caagtgggca tctggagcgg cccggcccct     2040

cagtgcatta tacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct     2100

gacaacagaa gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt     2160

gtcatgaaag gaccccgccg tgtgaagtgc caggccctga acaaatggga gccggagcta     2220

ccaagctgct ccagggtatg tcagccacct ccagatgtcc tgcatgctga gcgtacccaa     2280

agggacaagg acaacttttc acccgggcag gaagtgttct acagctgtga gcccggctat     2340

gacctcagag gggctgcgtc tatgcgctgc acaccccagg gagactggag ccctgcagcc     2400

cccacatgtg aagtgaaatc ctgtgatgac ttcatgggcc aacttcttaa tggccgtgtg     2460

ctatttccag taaatctcca gcttggagca aaagtggatt ttgtttgtga tgaaggattt     2520

caattaaaag gcagctctgc tagttattgt gtcttggctg gaatggaaag cctttggaat     2580

agcagtgttc cagtgtgtga acaaatcttt tgtccaagtc ctccagttat tcctaatggg     2640

agacacacag gaaaacctct ggaagtcttt ccctttggaa aagcagtaaa ttacacatgc     2700

gacccccacc cagacagagg gacgagcttc gacctcattg gagagagcac catccgctgc     2760

acaagtgacc ctcaagggaa tggggtttgg agcagccctg cccctcgctg tggaattctg     2820

ggtcactgtc aagccccaga tcattttctg tttgccaagt tgaaaaccca aaccaatgca     2880

tctgactttc ccattgggac atctttaaag tacgaatgcc gtcctgagta ctacgggagg     2940

ccattctcta tcacatgtct agataacctg gtctggtcaa gtcccaaaga tgtctgtaaa     3000

cgtaaatcat gtaaaactcc tccagatcca gtgaatggca tggtgcatgt gatcacagac     3060

atccaggttg gatccagaat caactattct tgtactacag ggcaccgact cattggtcac     3120

tcatctgctg aatgtatcct ctcaggcaat actgcccatt ggagcacgaa gccgccaatt     3180

tgtcaacgaa ttccttgtgg gctaccccca accatcgcca atggagattt cattagcacc     3240

aacagagaga attttcacta tggatcagtg gtgacctacc gctgcaatct tggaagcaga     3300

gggagaaagg tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat     3360

caagtgggca tctggagcgg ccccgcccct cagtgcatta tacctaacaa atgcacgcct     3420

ccaaatgtgg aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa     3480

gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc     3540

caggccctga acaaatggga gccagagtta ccaagctgct ccagggtgtg tcagccgcct     3600

ccagaaatcc tgcatggtga gcatacccca agccatcagg acaacttttc acctgggcag     3660

gaagtgttct acagctgtga gcctggctat gacctcagag gggctgcgtc tctgcactgc     3720

acaccccagg gagactggag ccctgaagcc ccgagatgtg cagtgaaatc ctgtgatgac     3780

ttcttgggtc aactccctca tggccgtgtg ctatttccac ttaatctcca gcttggggca     3840

aaggtgtcct ttgtctgtga tgaagggttt cgcttaaagg gcagttccgt tagtcattgt     3900

gtcttggttg gaatgagaag cctttggaat aacagtgttc ctgtgtgtga acatatcttt     3960

tgtccaaatc ctccagctat ccttaatggg agacacacag gaactccctc tggagatatt     4020

ccctatggaa aagaaatatc ttacacatgt gacccccacc cagacagagg gatgaccttc     4080

aacctcattg gggagagcac catccgctgc acaagtgacc ctcatgggaa tggggtttgg     4140

agcagccctg cccctcgctg tgaactttct gttcgtgctg gtcactgtaa aaccccagag     4200

cagtttccat ttgccagtcc tacgatccca attaatgact ttgagtttcc agtcgggaca     4260

tctttgaatt atgaatgccg tcctgggtat tttgggaaaa tgttctctat ctcctgccta     4320

gaaaacttgg tctggtcaag tgttgaagac aactgtagac gaaaatcatg tggacctcca     4380

ccagaaccct tcaatggaat ggtgcatata aacacagata cacagtttgg atcaacagtt     4440

aattattctt gtaatgaagg gtttcgactc attggttccc catctactac ttgtctcgtc     4500

tcaggcaata atgtcacatg ggataagaag gcacctattt gtgagatcat atcttgtgag     4560

ccacctccaa ccatatccaa tggagacttc tacagcaaca atagaacatc ttttcacaat     4620

ggaacggtgg taacttacca gtgccacact ggaccagatg gagaacagct gtttgagctt     4680

gtgggagaac ggtcaatata ttgcaccagc aaagatgatc aagttggtgt ttggagcagc     4740

cctccccctc ggtgtatttc tactaataaa tgcacagctc cagaagttga aaatgcaatt     4800

agagtaccag gaaacaggag tttctttacc ctcactgaga tcatcagatt tagatgtcag     4860

cccgggtttg tcatggtagg gtcccacact gtgcagtgcc agaccaatgg cagatggggg     4920

cccaagctgc cacactgctc cagggtgtgt cagccgcctc cagaaatcct gcatggtgag     4980

cataccctaa gccatcagga caacttttca cctgggcagg aagtgttcta cagctgtgag     5040

cccagctatg acctcagagg ggctgcgtct ctgcactgca cgccccaggg agactggagc     5100

cctgaagccc ctagatgtac agtgaaatcc tgtgatgact tcctgggcca actccctcat     5160

ggccgtgtgc tacttccact taatctccag cttggggcaa aggtgtcctt tgtttgcgat     5220

gaagggttcc gattaaaagg caggtctgct agtcattgtg tcttggctgg aatgaaagcc     5280

ctttggaata gcagtgttcc agtgtgtgaa caaatctttt gtccaaatcc tccagctatc     5340

cttaatggga gacacacagg aactcccttt ggagatattc cctatggaaa agaaatatct     5400

tacgcatgcg acacccaccc agacagaggg atgaccttca acctcattgg ggagagctcc     5460

atccgctgca caagtgaccc tcaagggaat ggggtttgga gcagccctgc ccctcgctgt     5520

gaactttctg ttcctgctgc ctgcccacat ccacccaaga tccaaaacgg gcattacatt     5580

ggaggacacg tatctctata tcttcctggg atgacaatca gctacatttg tgaccccggc     5640

tacctgttag tgggaaaggg cttcattttc tgtacagacc agggaatctg gagccaattg     5700

gatcattatt gcaaagaagt aaattgtagc ttcccactgt ttatgaatgg aatctcgaag     5760

gagttagaaa tgaaaaaagt atatcactat ggagattatg tgactttgaa gtgtgaagat     5820

gggtatactc tggaaggcag tccctggagc cagtgccagg cggatgacag atgggaccct     5880

cctctggcca aatgtacctc tcgtacacat gatgctctca tagttggcac tttatctggt     5940

acgatcttct ttattttact catcattttc ctctcttgga taattctaaa gcacagaaaa     6000

ggcaataatg cacatgaaaa ccctaaagaa gtggctatcc atttacattc tcaaggaggc     6060

agcagcgttc atccccgaac tctgcaaaca aatgaagaaa atagcagggt ccttccttga     6120


<210>  13
<211>  3597
<212>  DNA
<213>  Homo sapiens;

<400>  13
atgcgctcct tgagaaagaa gagagagaag cccagaccag agcagtggaa gggcctcccg       60

gggcccccca gagcgccaga gcctgaggat gtcgccgtcc cgggcggcgt ggacctcctc      120

accctgccgc agctgtgctt cccagggggt gtgtgcgtgg ccactgaacc taaggaggat      180

tgcgtccact tcctggtgct gaccgatgtc tgcgggaata ggacctatgg cgtggtggcc      240

cagtactacc ggcccctgca tgatgagtac tgtttctaca atggcaaaac gcaccgggag      300

tgtcctggct gcttcgtgcc cttcgcggtg tgcgtggtct ccaggtttcc ctattacaac      360

tccctcaagg actgcctttc ctgtttattg gctcttctga agccctgtaa agattttgaa      420

gtggacagtc atataaaaga tttcgctgcg aagctgtctt taatacccag cccgccacct      480

ggaccgctcc atttggtatt taacatgaag tcgctccaga ttgtgttacc tgcccgagca      540

gaccccgaaa gccccatcct ggacctggac cttcacctgc ccttgctgtg cttcaggcct      600

gagaaggtgc tacagatcct gacatgcatc ctgacggaac agcggatcgt cttcttctcc      660

tcggactggg ctctgctgac gctggtcact gagtgcttca tggcctacct gtatccgctg      720

cagtggcagc accccttcgt gcccatcctg tcggaccaga tgctggattt cgtcatggcc      780

cccacgtcct tcctgatggg ctgccatctc gaccacttcg aagaagtcag caaggaagcc      840

gacggtttag ttctgataaa tattgatcat gggagcatca cctactccaa gtccacggac      900

gataacgtgg acattcctga tgtccccctc ctggcagccc agacgtttat tcagagggtg      960

cagagcctcc agctccacca tgagctgcac gccgcccacc tcctctccag cacagacctg     1020

aaggagggcc gagcccaccg gcggtcctgg cagcagaaac tcaactgcca gatacagcag     1080

accaccctgc agctgctcgt gagcatcttc agggatgtaa agaatcattt aaactatgaa     1140

cacagagtct ttaatagtga agaatttctc aaaaccaggg ctccagggga ccatcagttt     1200

tataagcagg tcttagacac ctacatgttc cattcttttc ttaaagcccg gctcaatagg     1260

aggatggacg cctttgctca gatggacctc gacacccagt cggaggagga cagaataaat     1320

ggaatgcttc taagtccaag gagaccgacc gttgagaaaa gagcctcccg gaagtcctcg     1380

cacctgcatg tcacccacag gcgcatggtg gtcagcatgc ccaacctgca ggacattgcc     1440

atgcctgagc tggcacccag gaactcctcg ctccggctga cggacaccgc aggctgtagg     1500

ggcagcagcg cagttctgaa tgtcacgccg aagtccccgt atacattcaa gattcccgaa     1560

atccactttc cgctggagag caagtgcgtg caggcatacc atgcccactt tgtctccatg     1620

ctgagcgagg ccatgtgctt tctggccccc gataactctc tgctcctggc ccgctatttg     1680

tacctccgag ggctcgttta tctgatgcag ggacagctgc tgaacgccct cttggacttc     1740

cagaatctgt ataaaacaga catacggatc tttcccactg atttggtgaa gaggacggtg     1800

gaatccatgt ctgcccctga gtgggagggg gctgagcagg cgccggagct gatgaggctc     1860

atcagcgaga tcctggacaa gccgcacgag gcctcgaagc tggacgacca cgtgaagaag     1920

ttcaagctgc ccaagaagca catgcagctg ggcgacttca tgaagcgggt ccaggagtca     1980

gggatcgtga aggacgccag catcatacac cggctgttcg aggccttgac tgtaggacag     2040

gagaaacaaa tcgacccaga aacattcaaa gatttctaca actgctggaa ggagacggaa     2100

gcagaagccc aggaggtcag tctgccgtgg ctggtgatgg aacacctgga taaaaacgag     2160

tgtgtgtgta agttgtccag ctccgtcaag acaaacctag gcgttggcaa gatcgccatg     2220

acccagaagc gcctgttcct cctaaccgaa ggaaggccag gctacttgga gatttccacc     2280

ttcagaaata tagaggaggt caggagaacc actactacat ttctacttcg gagaataccc     2340

actttaaaaa tcagagtggc gtccaagaaa gaagtcttcg aagccaacct gaaaaccgag     2400

tgtgaccttt ggcacctgat ggtgaaggag atgtgggctg ggaagaagct ggccgatgac     2460

cacaaggacc ctcactacgt ccagcaggcg ctgaccaacg tcttgctgat ggacgccgtc     2520

gtgggcacac tgcagtcacc aggcgccatc tacgctgcct ccaagttatc ctactttgat     2580

aagatgagta acgaaatgcc catgacgctt ccggagacaa ccctggaaac actgaagcat     2640

aaaatcaacc cctcggcggg ggaggcgttc ccacaagcgg tggacgtgct gctctacact     2700

ccagggcatc ttgacccagc cgaaaaagtt gaagatgctc accccaagtt atggtgtgct     2760

ctgagcgaag gcaaggtgac cgtgttcaat gcttcttcat ggaccatcca ccagcactcc     2820

tttaaagtgg gcactgcaaa agtgaactgc atggtgatgg ccgaccagaa ccaggtgtgg     2880

gttggctcgg aagactccgt catctacatc atcaacgtcc acagcatgtc ctgcaacaag     2940

cagctcacag cccactgctc cagtgtcacg gatttgattg tgcaggacgg acaggaggca     3000

cccagcaacg tgtactcgtg cagcatggac ggcatggtgc tggtgtggaa tgtgagcaca     3060

ctgcaggtga ccagccgctt ccagctgccg cgaggtggcc tgacgtccat cagactgcac     3120

ggcggccgcc tgtggtgctg cacaggtaac agcatcatgg tcatgaaaat gaatggatcc     3180

ctccatcaag aattgaagat tgaggagaac ttcaaagaca ccagtacctc cttcctggcc     3240

ttccagctcc ttcctgagga ggagcagctg tgggcggcct gtgcaggacg cagcgaggtt     3300

tacatctgga gcctgaagga cctggcccag cccccgcaga gggtgcccct cgaggactgc     3360

tctgagatca actgcatgat ccgggtgaag aagcaggtct gggtgggcag ccgagggctg     3420

gggcagggaa cacccaaggg gaaaatctac gtgattgacg ccgagaggaa gaccgtggag     3480

aaggagctgg tggcgcacat ggacaccgtg aggacgctgt gctcggctga ggacagatac     3540

gtgctgagtg ggtcgggcag ggaggagggg aaagtcgcca tttggaaagg cgaataa        3597


<210>  14
<211>  5613
<212>  DNA
<213>  Homo sapiens;

<400>  14
atggcccgct ggatcccgac caagaggcag aagtacgggg ttgcgatcta taactacaat       60

gcttctcaag atgtggagct ctccttgcag atcggtgaca cagttcacat cctggagatg      120

tacgagggtt ggtacagagg atataccctc caaaataaat ctaaaaaggg cattttccct      180

gaaacatata tccatttgaa agaggcaact gtggaagacc tggggcagca tgaaaccgtg      240

attcctggcg agctccccct ggtgcaggag ctcacgtcca ctctgcgaga atgggctgtc      300

atctggcgaa agctctacgt gaacaacaag ctcaccctct tccgccagct gcagcagatg      360

acgtacagcc tgatcgagtg gcggtcccag atcctgtctg ggacgctccc caaggatgaa      420

ctggcagagc tcaagaagaa agtcacagcc aaaattgatc atgggaacag aatgctgggg      480

ttagatctgg tggtgcgaga tgacaatggg aacatcctag accctgacga aaccagcacc      540

attgccctct tcaaggccca tgaggtggcc tccaaaagga ttgaggaaaa gatccaagaa      600

gagaagtcaa tcctgcagaa cctcgatttg cggggccagt ccatcttcag taccatccac      660

acctatggcc tctatgtgaa cttcaagaac tttgtctgca acatcgggga agatgcagag      720

ttgtttatgg ccctctacga cccagaccag tccactttta tcagtgagaa ctatctaatt      780

cgttggggca gtaacgggat gcccaaggaa atagagaagc tcaataacct ccaagcagtg      840

tttacagacc ttagcagcat ggacctcatc cggccccgcg tcagccttgt gtgccagatt      900

gtccgcgtgg gccatatgga gctgaaggaa ggcaagaagc acacctgtgg actccgaaga      960

ccttttggag tggcagtgat ggatattact gatatcatac atgggaaggt ggatgatgaa     1020

gaaaagcagc attttattcc ctttcagcaa attgcgatgg aaacctacat ccgccagagg     1080

cagctcatca tgtcgccttt gataacatca cacgtgattg gggagaatga gccactcact     1140

tcagtcttga ataaagtgat tgcagcaaag gaagtgaatc acaaagggca aggcctttgg     1200

gtatccttga agctcttgcc cggtgacctc acccaggttc agaagaattt ttcacacttg     1260

gttgatagat caacagcaat agcccggaag atgggctttc ctgaaatcat actgccagga     1320

gatgttcgga atgacattta tgtcaccctg atccacggtg agtttgacaa agggaagaag     1380

aagacgccaa agaatgtgga ggtgacgatg tctgtgcacg atgaggaggg caagctcttg     1440

gagaaagcaa ttcaccctgg tgctggatat gaaggcattt cagaatacaa atcagtagtc     1500

tattaccaag tcaagcagcc ctgttggtat gagactgtca aggtatccat tgctatagaa     1560

gaagtcacac gctgtcatat aagatttacc ttccgacaca ggtcatctca ggaaaccaga     1620

gataaatcgg agcgagcatt tggggtggcc ttcgtgaagc tgatgaaccc ggatggcacc     1680

actctgcagg atgggaggca cgatctggtg gtttataagg gtgacaacaa aaaaatggaa     1740

gatgctaaat tctacctgac cctgcctgga accaagatgg agatggaaga aaaagagctt     1800

caagcatcca aaaacctggt caccttcacc ccaagcaagg atagcactaa agacagcttt     1860

cagattgcca ccctcatctg ctccacaaag ctcacccaga atgttgacct gttaggcttg     1920

ttaaattggc gttccaactc ccagaacatt aaacacaacc taaagaagtt aatggaagtg     1980

gatggaggag agattgttaa gtttttgcaa gatacactag atgcactctt taacataatg     2040

atggaaatgt cagacagtga aacctatgac ttccttgtgt ttgacgcact ggtatttatt     2100

atttcactga taggagacat caagttccag cattttaatc ctgtacttga aacctacatt     2160

tacaagcact tcagcgccac tttggcatat gtgaaactct ccaaggtact gaacttctat     2220

gtggctaatg cagatgactc cagcaagact gaactgcttt ttgctgcgtt gaaagccttg     2280

aagtacttgt ttagattcat catccaatcc cgagtgctct acttgagatt ttatgggcag     2340

agcaaagatg gagatgagtt taataattca attcgccagt tatttcttgc tttcaatatg     2400

ctgatggaca ggcctctgga ggaagccgtc aagatcaagg gggcagcttt gaagtacctt     2460

cctagcataa ttaatgatgt caaacttgta tttgatcctg ttgagctcag cgtgctcttc     2520

tgcaaattca ttcaaagcat tcctgacaac cagctggttc ggcagaaact taactgcatg     2580

accaagatag tagagagcac tctttttcga cagtcagagt gcagagaagt gctgctgcca     2640

ctgctgacag accagctcag cggccagtta gatgacaact ccaacaagcc tgaccacgag     2700

gcaagctcgc agcttctgag caacatcctg gaggtgctgg acaggaagga tgtgggtgcc     2760

actgcggtgc acattcagct tataatggaa cggctgctga gaaggatcaa ccggacagtg     2820

attgggatga accggcagtc tccccacatc gggagttttg tggcttgcat gattgccctg     2880

ctgcagcaaa tggacgacag ccactatagc cactacatca gcactttcaa aaccagacaa     2940

gacatcatcg acttcctcat ggaaactttt atcatgttca aggacctgat tggaaagaat     3000

gtctatgcca aagattggat ggtgatgaat atgactcaaa acagggtttt tctccgtgct     3060

ataaatcagt ttgctgaagt tctcacaaga ttcttcatgg atcaggcaag ctttgaactt     3120

cagctctgga acaattactt ccatttggca gttgcatttc tcacccatga gtcccttcag     3180

cttgaaacct tctcacaagc caagcgcaac aaaattgtta aaaaatatgg ggacatgaga     3240

aaggaaatcg gctttagaat ccgggacatg tggtataacc tgggtcccca caaaatcaaa     3300

ttcatcccat ccatggtggg tcccattctg gaggtcactc tgacccctga agtagagctc     3360

cggaaagcca caatccccat tttctttgat atgatgcagt gtgagttcaa tttcagtgga     3420

aatggcaatt tccatatgtt tgagaatgag ctgatcacaa agctggacca ggaggtagaa     3480

gggggcagag gagacgaaca atacaaggtt cttctggaaa aactgctcct agaacattgc     3540

cggaaacaca aatacctctc cagctctggg gaggtcttcg ccctcctggt cagcagcctc     3600

ttagagaacc tgctggacta tagaaccatc atcatgcaag atgagagcaa ggagaaccgt     3660

atgagctgca ctgtgaacgt gctgaacttt tataaagaaa agaagagaga ggacatatac     3720

ataagatatc tgtacaagct tcgagatttg caccgagact gtgagaacta cacagaagct     3780

gcctacacgc ttctcttgca cgctgagctt ctgcagtggt ctgacaagcc ctgtgtgcct     3840

catttgcttc agaaggacag ttactatgtt tatacccagc aagagcttaa agagaagctg     3900

tatcaagaaa tcatatcata tttcgacaaa ggcaaaatgt gggagaaggc catcaagctg     3960

agcaaagagt tggctgagac ttacgaaagc aaagtatttg actacgaggg ccttggcaac     4020

ctcctgaaaa aaagggcctc attttatgag aacatcatta aggcaatgag gcctcagcct     4080

gaatactttg ctgttggata ctatggacag ggctttcctt ctttcctacg gaataaaatc     4140

ttcatctatc ggggaaagga gtatgagagg cgagaggact tcagcctgag gttgttaacc     4200

cagttcccca atgcggagaa gatgaccagt accacgcctc ctggggaaga catcaagtcg     4260

tcccccaagc agtacatgca gtgcttcact gtaaagccag tgatgagctt gccgcccagc     4320

tacaaggata aacctgttcc agagcagatc ttaaactact acagagccaa tgaagtgcag     4380

cagttcagat actcccggcc gttccggaaa ggagaaaagg atccagacaa tgaatttgct     4440

acgatgtgga ttgaacggac cacgtatacg actgcatata cctttcctgg gattctcaag     4500

tggtttgaag tcaaacagat ttcaacagaa gagatcagtc ctctggagaa tgccatcgaa     4560

accatggagc tgaccaacga gaggatcagc aactgtgttc agcagcatgc ctgggaccgg     4620

tccctctctg tgcaccctct ctccatgctg ctcagtggca tcgtggaccc ggccgtcatg     4680

gggggcttct ccaactatga aaaggctttt tttacagaaa agtacttgca ggagcatcct     4740

gaagaccagg agaaggttga gctgctaaag cgactaatag cattacagat gcccctgcta     4800

acagaaggga tccgcatcca tggggagaaa ctcacagagc agctgaagcc gctgcatgag     4860

cggttgtctt cttgcttccg ggaactcaag gagaaagtag aaaagcacta tggggttata     4920

acactgccac ccaacttgac ggagaggaag caaagccgca cggggtctat tgtgctcccc     4980

tacatcatgt cttccactct gcggaggttg tccatcacct cagtcacttc ctctgtggtt     5040

tccacctctt caaactcgtc tgacaatgct ccttccagac cgggatctga tggctcaatc     5100

ttggagccac ttttggagcg cagggcctcg tcaggtgcca gagttgaaga tctgtccctt     5160

agagaggaga acagcgagaa ccggatcagc aagtttaaga gaaaagactg gagtctgagc     5220

aagtcccagg tcattgcaga gaaagcacca gaacccgatt tgatgagccc aaccagaaaa     5280

gcacaaaggc caaagagtct ccagttgatg gataatcggc tatcaccatt tcacggttct     5340

tcacctcctc agtcaacacc cttgagccca cctccactca ctcccaaagc caccaggacc     5400

ctaagctccc catcgttgca gacagatgga atcgcggcca ctcctgtccc acctccacct     5460

ccccccaaaa gcaagcccta tgaaggcagc cagaggaact ccactgagct cgctccccca     5520

ctgcctgtcc gaagagaagc caaagcacca ccccctccac ctccaaaggc tcggaagtct     5580

ggcatcccta cttccgagcc tggatcccag taa                                  5613


<210>  15
<211>  1815
<212>  DNA
<213>  Homo sapiens;

<400>  15
atggctagga tcagtttttc ctacctctgc ccagcctcct ggtacttcac tgtgcccaca       60

gtgagtccat ttctccgtca gcgggtggca ttcctgggac tcttcttcat atcctgtctc      120

cttttactta tgttaatcat agactttcga cattggagtg cttcattacc acgagatagg      180

caatacgaaa ggtatttggc tcgagtaggg gagcttgaag ctactgacac tgaagaccca      240

aatctgaatt atggacttgt tgttgactgt ggcagcagtg gttcccggat ttttgtttat      300

ttctggccaa gacataatgg gaacccccat gacttgctgg acatcaaaca gatgagagac      360

cgcaacagcc aaccagtggt taaaaaaatc aagccaggaa tctctgcaat ggcagacact      420

ccagaacatg ccagtgatta ccttcgtcct ctgctgagct ttgctgctgc tcatgtgcct      480

gtgaagaagc acaaggagac ccctctttac atcctctgca cagcaggcat gaggcttctc      540

cctgagagga agcagttggc tatcttggct gacctagtga aagatttacc actggagttt      600

gacttcctct tttcacagtc tcaagcagaa gtgatctctg ggaagcagga aggggtttat      660

gcatggattg gaatcaactt tgttttggga agattcgacc acgaggatga atcagatgct      720

gaggctaccc aggaattggc agcaggacgg agaaggacag tagggatact ggatatggga      780

ggagcctctc tccaaattgc ttatgaagtt cctacctcaa cctctgtcct tcctgcaaag      840

caggaagaag ctgccaagat cctgctggct gagttcaacc tgggctgtga tgtgcaacac      900

actgaacacg tgtacagggt ttatgtcaca acttttctgg gtttcggagg caactttgcc      960

cggcagcgct acgaagacct tgttctgaat gaaactctta acaaaaacag attgcttggt     1020

cagaagacag gtctgagtcc cgacaatcca tttctggatc cctgcctgcc agtgggactc     1080

acagatgtgg tggagaggaa cagccaagtc ttacatgtcc gaggaagagg agactgggtg     1140

tcttgtgggg caatgctgag ccccctgctg gctcgctcca acaccagcca ggcctcactc     1200

aatggcatat atcaatcgcc tattgacttc aacaacagcg agttctacgg cttctctgag     1260

tttttttatt gtacagagga tgtgttgcgc attggtggcc gctaccatgg gccaacattt     1320

gccaaggctg ctcaggatta ctgtggcatg gcttggtcgg tactaactca gagattcaag     1380

aatggcctct tttcatcaca tgcagatgag catcgactca aatatcagtg ttttaaatcg     1440

gcttggatgt accaagtctt acatgaagga ttccactttc cctatgacta cccaaacctg     1500

cggacagccc agctggtgta tgaccgagag gttcagtgga cgctgggagc cattctatat     1560

aaaacacgat tcttaccact cagggatctt cggcaggaag gtgtccgaca agcccatggt     1620

agctggttcc gtctctcctt tgtatacaac cactatctct tctttgcctg tatcctggtg     1680

gtgctactgg ccatcttcct ataccttctg cggctacgcc gaattcacca ccgacaaaca     1740

cgagcctcag ctccattgga cttgctgtgg cttgaagagg tggtgcccat gatgggagta     1800

caggtggggc cgtga                                                      1815


<210>  16
<211>  2964
<212>  DNA
<213>  Homo sapiens;

<400>  16
atggagctcc gggtgctgct ctgctgggct tcgttggccg cagctttgga agagaccctg       60

ctgaacacaa aattggaaac tgctgatctg aagtgggtga cattccctca ggtggacggg      120

cagtgggagg aactgagcgg cctggatgag gaacagcaca gcgtgcgcac ctacgaagtg      180

tgtgacgtgc agcgtgcccc gggccaggcc cactggcttc gcacaggttg ggtcccacgg      240

cggggcgccg tccacgtgta cgccacgctg cgcttcacca tgctcgagtg cctgtccctg      300

cctcgggctg ggcgctcctg caaggagacc ttcaccgtct tctactatga gagcgatgcg      360

gacacggcca cggccctcac gccagcctgg atggagaacc cctacatcaa ggtggacacg      420

gtggccgcgg agcatctcac ccggaagcgc cctggggccg aggccaccgg gaaggtgaat      480

gtcaagacgc tgcgtctggg accgctcagc aaggctggct tctacctggc cttccaggac      540

cagggtgcct gcatggccct gctatccctg cacctcttct acaaaaagtg cgcccagctg      600

actgtgaacc tgactcgatt cccggagact gtgcctcggg agctggttgt gcccgtggcc      660

ggtagctgcg tggtggatgc cgtccccgcc cctggcccca gccccagcct ctactgccgt      720

gaggatggcc agtgggccga acagccggtc acgggctgca gctgtgctcc ggggttcgag      780

gcagctgagg ggaacaccaa gtgccgagcc tgtgcccagg gcaccttcaa gcccctgtca      840

ggagaagggt cctgccagcc atgcccagcc aatagccact ctaacaccat tggatcagcc      900

gtctgccagt gccgcgtcgg gtacttccgg gcacgcacag acccccgggg tgcaccctgc      960

accacccctc cttcggctcc gcggagcgtg gtttcccgcc tgaacggctc ctccctgcac     1020

ctggaatgga gtgcccccct ggagtctggt ggccgagagg acctcaccta cgccctccgc     1080

tgccgggagt gccgacccgg aggctcctgt gcgccctgcg ggggagacct gacttttgac     1140

cccggccccc gggacctggt ggagccctgg gtggtggttc gagggctacg tcctgacttc     1200

acctatacct ttgaggtcac tgcattgaac ggggtatcct ccttagccac ggggcccgtc     1260

ccatttgagc ctgtcaatgt caccactgac cgagaggtac ctcctgcagt gtctgacatc     1320

cgggtgacgc ggtcctcacc cagcagcttg agcctggcct gggctgttcc ccgggcaccc     1380

agtggggctg tgctggacta cgaggtcaaa taccatgaga agggcgccga gggtcccagc     1440

agcgtgcggt tcctgaagac gtcagaaaac cgggcagagc tgcgggggct gaagcgggga     1500

gccagctacc tggtgcaggt acgggcgcgc tctgaggccg gctacgggcc cttcggccag     1560

gaacatcaca gccagaccca actggatgag agcgagggct ggcgggagca gctggccctg     1620

attgcgggca cggcagtcgt gggtgtggtc ctggtcctgg tggtcattgt ggtcgcagtt     1680

ctctgcctca ggaagcagag caatgggaga gaagcagaat attcggacaa acacggacag     1740

tatctcatcg gacatggtac taaggtctac atcgacccct tcacttatga agaccctaat     1800

gaggctgtga gggaatttgc aaaagagatc gatgtctcct acgtcaagat tgaagaggtg     1860

attggtgcag gtgagtttgg cgaggtgtgc cgggggcggc tcaaggcccc agggaagaag     1920

gagagctgtg tggcaatcaa gaccctgaag ggtggctaca cggagcggca gcggcgtgag     1980

tttctgagcg aggcctccat catgggccag ttcgagcacc ccaatatcat ccgcctggag     2040

ggcgtggtca ccaacagcat gcccgtcatg attctcacag agttcatgga gaacggcgcc     2100

ctggactcct tcctgcggct aaacgacgga cagttcacag tcatccagct cgtgggcatg     2160

ctgcggggca tcgcctcggg catgcggtac cttgccgaga tgagctacgt ccaccgagac     2220

ctggctgctc gcaacatcct agtcaacagc aacctcgtct gcaaagtgtc tgactttggc     2280

ctttcccgat tcctggagga gaactcttcc gatcccacct acacgagctc cctgggagga     2340

aagattccca tccgatggac tgccccggag gccattgcct tccggaagtt cacttccgcc     2400

agtgatgcct ggagttacgg gattgtgatg tgggaggtga tgtcatttgg ggagaggccg     2460

tactgggaca tgagcaatca ggacgtgatc aatgccattg aacaggacta ccggctgccc     2520

ccgcccccag actgtcccac ctccctccac cagctcatgc tggactgttg gcagaaagac     2580

cggaatgccc ggccccgctt cccccaggtg gtcagcgccc tggacaagat gatccggaac     2640

cccgccagcc tcaaaatcgt ggcccgggag aatggcgggg cctcacaccc tctcctggac     2700

cagcggcagc ctcactactc agcttttggc tctgtgggcg agtggcttcg ggccatcaaa     2760

atgggaagat acgaagaaag tttcgcagcc gctggctttg gctccttcga gctggtcagc     2820

cagatctctg ctgaggacct gctccgaatc ggagtcactc tggcgggaca ccagaagaaa     2880

atcttggcca gtgtccagca catgaagtcc caggccaagc cgggaacccc gggtgggaca     2940

ggaggaccgg ccccgcagta ctga                                            2964


<210>  17
<211>  2760
<212>  DNA
<213>  Homo sapiens;

<400>  17
atgacaggct ataccatgct gcggaatggg ggcgcgggga acggaggtca gacctgcatg       60

ctgcgctggt ccaaccgcat ccgcctcacg tggctcagct tcacgctctt tgtcatcctg      120

gtcttcttcc cgctcatcgc ccactattac ctcaccactc tggatgaggc tgatgaggca      180

ggcaagcgga tttttggtcc ccgggtgggg aacgagctgt gcgaggtgaa gcacgtgctg      240

gatctgtgcc gcatccggga gtcggtgagt gaagagctcc tgcagctgga ggccaagcgc      300

caagagctga acagcgagat cgccaagctg aatctgaaga tcgaagcctg taagaagagc      360

attgagaacg ccaagcagga cctgctccag ctcaagaatg tcatcagcca gaccgagcat      420

tcctacaagg agctcatggc ccagaaccag cccaagctgt ccctgcccat ccgactgctc      480

ccagagaagg acgatgccgg cctccctccc ccgaaggcca ctcggggctg ccggctacac      540

aactgctttg attattctcg ttgccctctc acctctggct tcccggtcta cgtctatgac      600

agtgaccagt ttgtctttgg cagctacctg gatcccttgg tcaagcaggc ttttcaggcg      660

acagcacgag ctaacgttta tgttacagaa aatgcagaca tcgcctgcct ttacgtgata      720

ctagtgggag agatgcagga gccggtggtg ctgcggcctg ctgagctgga gaagcagttg      780

tattccctgc cacactggcg gacggatgga cacaaccatg tcatcatcaa tctgtcacgt      840

aagtcagata cacagaacct tctctataac gtcagtactg gccgtgccat ggtggcccag      900

tccaccttct acactgtcca gtacagacct ggctttgact tggtcgtatc accgctggtc      960

catgccatgt ctgagcccaa cttcatggaa atcccaccac aggtgccggt gaagcggaaa     1020

tatctcttca ccttccaggg cgagaagatt gagtctctga ggtctagcct tcaggaggcc     1080

cgctccttcg aagaggaaat ggagggcgac cctcccgccg actacgatga ccggatcatt     1140

gccaccctga aggcggtgca ggacagcaag ctggatcagg tcctggtgga attcacctgc     1200

aaaaaccagc ccaaacccag cctgccgact gagtgggcac tgtgtggaga gcgggaggac     1260

cgcttggaat tgctgaagct ctccaccttc gccctcatca ttacccccgg ggaccctcgc     1320

ttggttattt cctctgggtg tgcaacacgg ctcttcgaag ccctggaagt cggtgccgtc     1380

ccggtggtgc tgggggagca ggtccagctt ccctaccagg acatgctgca gtggaacgag     1440

gcggccctgg tggtgccaaa gcctcgtgtt accgaggttc atttcctgct cagaagcctc     1500

tccgatagtg acctcctggc tatgaggcgg caaggccgct ttctctggga gacttacttc     1560

tccactgctg acagtatttt taataccgtg ctggctatga ttaggactcg catccagatc     1620

ccagccgctc ccatccggga agaggcggca gctgagatcc cccaccgttc aggcaaggcg     1680

gctggaactg accccaacat ggctgacaac ggggacctgg acctggggcc agtggagacg     1740

gagccgccct acgcctcacc cagatacctc cgcaatttca ctctgactgt cactgacttt     1800

taccgcagct ggaactgtgc tccagggcct ttccatcttt tcccccacac tccctttgac     1860

cctgtgttgc cctcagaggc caaattcttg ggctcaggga ctggctttcg gcctattggt     1920

ggtggagctg ggggttctgg caaggaattt caggcagcgc ttggaggcaa tgttccccga     1980

gagcagttca cggtggtgat gttgacttat gagcgggagg aagtgcttat gaactcttta     2040

gagaggctga atggcctccc ttacctgaac aaggtcgtgg tggtgtggaa ttctcccaag     2100

ctgccatcag aggaccttct gtggcctgac attggcgtcc ccatcatggt ggtccgtact     2160

gagaagaaca gtttgaacaa ccgattctta ccctggaatg aaattgagac agaggccatc     2220

ctgtccattg atgacgatgc tcacctccgc catgacgaaa tcatgtttgg gttccgggtg     2280

tggagagaag ctcgggaccg catcgtgggc ttccctggcc gttaccacgc atgggacatc     2340

ccccatcagt cctggctcta caactccaac tactcctgtg agctgtccat ggtgctgaca     2400

ggtgctgcct tctttcacaa gtattatgcc tacctgtatt cttatgtgat gccccaggcc     2460

atccgggaca tggtggatga atacatcaac tgtgaggaca ttgccatgaa cttccttgtc     2520

tcccacatca ctcggaagcc ccccatcaag gtgacctcac ggtggacatt ccgatgccca     2580

ggatgccctc aggccctgtc tcatgatgac tcccacttcc acgagcggca caagtgcatc     2640

aacttcttcg tgaaggtgta cggctacatg cccctcctgt acacgcagtt cagggtggat     2700

tctgtgctct tcaagacacg cctgccccat gacaagacca agtgcttcaa gttcatctag     2760


<210>  18
<211>  2787
<212>  DNA
<213>  Homo sapiens;

<400>  18
atgggcggct cagcctccag ccagctggac gagggcaagt gcgcttacat ccgagggaaa       60

actgaggctg ccatcaaaaa cttcagtccc tactacagtc gtcagtactc tgtggctttc      120

tgcaatcacg tgcgcactga agtagaacag caaagagatt taacgtcaca gtttttgaag      180

accaagccac cattggcgcc tggaactatt ttgtatgaag cagagctatc acaattttct      240

gaagacataa agaagtggaa ggagagatac gttgtagtta aaaatgatta tgctgtggag      300

agctatgaga ataaagaggc ctatcagaga ggagctgctc ctaaatgtcg aattcttcca      360

gccggtggca aggtgttaac ctcagaagat gaatataatc tgttgtctga caggcatttc      420

ccagaccctc ttgcctccag tgagaaggag aacactcagc cctttgtggt cctgcccaag      480

gaattcccag tgtacctgtg gcagcccttc ttcagacacg gctacttctg cttccacgag      540

gctgctgacc agaagaggtt tagtgccctc ctgagtgact gcgtcaggca tctcaatcat      600

gattacatga agcagatgac atttgaagcc caagcctttt tagaagctgt gcaattcttc      660

cgacaggaga agggtcacta tggttcctgg gaaatgatca ctggggatga aatccagatc      720

ctgagtaacc tggtgatgga ggagctcctg cccactcttc agacagacct gctgcctaag      780

atgaagggga agaagaatga cagaaagagg acgtggcttg gtctcctcga ggaggcctac      840

accctggttc agcatcaagt ttcagaagga ttaagtgcct tgaaggagga atgcagagct      900

ctgacaaagg gcctggaagg aacgatccgt tctgacatgg atcagattgt gaactcaaag      960

aactatttaa ttggaaagat caaagcgatg gtggcccagc cggcggagaa aagctgcttg     1020

gagagtgtgc agccattcct ggcatccatc ctggaggagc tcatgggacc agtgagctcg     1080

ggattcagtg aagtacgtgt actctttgag aaagaggtga atgaagtcag ccagaacttc     1140

cagaccacca aagacagtgt ccagctaaag gagcatctag accggcttat gaatcttccg     1200

ctgcattccg tgaagatgga accttgttat actaaagtca acctgcttca cgagcgcctg     1260

caggatctca agagccgctt cagattcccc cacattgatc tggtggttca gaggacacag     1320

aactacatgc aggagctaat ggagaatgca gtgttcactt ttgagcagtt gctttcccca     1380

catctccaag gagaggcctc caaaactgca gttgccattg agaaggttaa actccgagtc     1440

ttaaagcaat atgattatga cagcagcacc atccgaaaga agatatttca agaggcacta     1500

gttcaaatca cacttcccac tgtgcagaag gcactggcgt ccacatgcaa accagagctt     1560

cagaaatacg agcagttcat ctttgcagat cataccaata tgattcacgt tgaaaatgtc     1620

tatgaggaga ttttacatca gatcctgctt gatgaaactc tgaaagtgat aaaggaagct     1680

gctatcttga agaaacacaa cttatttgaa gataacatgg ccttgcccag tgaaagtgtg     1740

tccagcttaa cagatctaaa gccccccaca gggtcaaacc aggccagccc tgccaggaga     1800

gcttctgcca ttctgccagg agttctgggt agtgagaccc tcagtaacga agtattccag     1860

gagtcagagg aagagaagca gcctgaggtc cctagctcgt tggccaaagg agaaagcctt     1920

tctctccctg ggccaagccc acccccagat gggactgagc aggtgattat ttcaagagtg     1980

gatgaccccg tggtgaatcc tgtggcaaca gaggacacag caggactccc gggcacatgc     2040

tcatcagagc tggagtttgg agggaccctt gaggatgaag aacccgccca ggaagagcca     2100

gaacccatca ctgcctcggg ttctttgaag gcgctcagaa agttgctgac agcgtccgtg     2160

gaagtaccag tggactctgc tccagtgatg gaagaagata cgaatgggga gagccacgtt     2220

ccccaagaaa atgaagaaga agaggaaaaa gagcccagtc aggcagctgc catccacccc     2280

gacaactgtg aagaaagtga agtcagcgag agggaggccc aacctccctg tcccgaggcc     2340

catggggagg agttgggggg atttccagag gtaggcagcc cagcctctcc gccagccagt     2400

ggagggctca ccgaggagcc cctggggccc atggaggggg agctcccagg agaggcctgc     2460

acactcactg cccatgaagg aagagggggc aagtgtaccg aggaagggga tgcctcacag     2520

caagagggct gcaccttagg ttctgacccc atctgcctca gtgagagcca ggtttctgag     2580

gaacaagaag agatgggagg gcaaagcagc gcggcccagg ccacggccag tgtgaatgca     2640

gaggagatca aggtagcccg tattcatgag tgtcagtggg tggtggagga tgctccaaac     2700

ccggatgtcc tgctgtcaca caaagatgac gtgaaggagg gagaaggtgg tcaggagagt     2760

ttcccagagc tgccctcaga ggagtga                                         2787


<210>  19
<211>  1107
<212>  DNA
<213>  Homo sapiens;

<400>  19
atggcggcag cggcggagga gcggatggca gaggaaggag gcggcggcca aggcgacggc       60

ggttcctctt tggcctccgg ctctacccag cgacagcctc caccgcccgc gccacagcac      120

ccgcagccgg ggtcccaggc gctcccagcc cccgcgctgg ctccggacca gctgcctcaa      180

aacaacacgc ttgtggcgct gcccatcgta gccatcgaga acatcctcag ctttatgtcc      240

tacgacgaaa ttagccagct ccgcctggtt tgtaaaagaa tggacttggt ctgccagaga      300

atgttgaatc agggatttct gaaagtggag aggtaccata atctatgtca gaaacaagtt      360

aaagcacaac tcccaaggag agagtcagaa aggagaaacc attcattagc tcgtcatgca      420

gacattcttg ctgctgttga aacaaggctg tcactattaa atatgacttt catgaaatat      480

gtggattcca atctctgttg cttcatccca ggaaaggtga ttgatgagat ttatcgtgtg      540

ttgagatatg tcaattctac cagagcccct caacgagctc atgaagtact tcaagaatta      600

agggatatat cctctatggc aatggagtac tttgatgaaa agattgttcc aattttaaag      660

aggaaattac caggatcaga tgtttctgga agactcatgg gctctcctcc agttccagga      720

ccgtctgcag ccctaacaac aatgcagctc ttctccaagc aaaatccttc aagacaagag      780

gttaccaaac tccagcagca ggttaaaaca aatggtgctg gcgtgactgt tctcaggcgt      840

gaaatttctg agcttcgcac caaagtgcaa gaacagcaaa aacagcttca agaccaggac      900

cagaaactgc tagagcagac ccagatcata ggtgaacaaa atgcacggtt ggcagagcta      960

gaacgcaaac tacgagaagt aatggaaagt gctgtaggaa attcctcagg gtccgggcag     1020

aatgaggagt ctcctcggaa acgaaaaaag gccacggaag ccatagactc tcttaggaaa     1080

tctaaacgtc ttcggaatag aaagtaa                                         1107


<210>  20
<211>  2724
<212>  DNA
<213>  Homo sapiens;

<400>  20
atgcccacgg ccgccgcccc catcatcagc tcggtccaga agctggttct gtatgagact       60

agagctagat actttctagt tgggagcaat aatgcagaaa cgaaatatcg tgtcttgaag      120

attgatagaa cagaaccaaa agatttggtc ataattgatg acaggcatgt ctatactcaa      180

caagaagtaa gggaacttct tggccgcttg gatcttggaa atagaacaaa gatgggacag      240

aaaggatcct cgggcttatt tcgagcggtt tcagcttttg gtgttgtggg ttttgtcagg      300

ttcttagaag gctattatat tgtgttaata actaaaagga ggaagatggc ggatattgga      360

ggtcatgcaa tctataaggt cgaagataca aatatgatct atatacccaa tgattctgta      420

cgggttactc atcctgatga agctaggtat ctacgaatat ttcaaaatgt ggacctatct      480

agcaattttt actttagtta cagctatgat ttgtcccact cacttcaata taatctcact      540

gtcttgcgaa tgcccctgga gatgttaaag tcagaaatga cccagaatcg ccaagagagc      600

tttgacatct ttgaagatga aggattaatt acacaaggtg gaagcggggt atttgggatc      660

tgtagtgagc cttatatgaa atatgtatgg aatggtgaac ttctggatat aattaaaagt      720

actgtgcatc gtgactggct tttgtatatt attcatgggt tctgtgggca gtcaaagctg      780

ttgatctatg gacgaccagt gtatgtcact ctaatagcta gaagatccag taaatttgct      840

ggcacccgtt ttcttaaaag aggtgcaaac tgtgagggtg atgttgcaaa tgaagtggag      900

actgaacaaa tactctgcga tgcttctgtg atgtctttca ctgcaggaag ttattcttca      960

tatgtacaag ttagaggatc tgtgccctta tactggtctc aggacatttc aactatgatg     1020

cctaaaccac ctattacatt ggatcaggca gatccatttg cacatgtggc tgcccttcac     1080

tttgaccaga tgttccagag gtttggctct cccatcatca tcttgaattt agtgaaggaa     1140

cgagagaaaa gaaagcatga aagaattctg agtgaagaac ttgttgctgc tgtgacctat     1200

ctcaaccaat ttttgcctcc tgagcacact attgtttata ttccctggga catggccaag     1260

tataccaaaa gcaagctgtg taatgttctt gatcgactaa atgtgattgc agaaagtgtg     1320

gtgaagaaaa caggtttctt tgtaaaccgc cctgattctt actgtagcat tttgcggcca     1380

gatgaaaagt ggaatgaact aggaggatgt gtgattccca ctggtcgcct gcagactggc     1440

atccttcgaa ccaactgtgt ggactgttta gatcgcacca acacagcaca gtttatggtg     1500

ggaaaatgtg ctctggccta tcagctgtat tcactgggac tgattgacaa acctaatcta     1560

cagtttgata cagatgcagt taggttattt gaggaactct atgaagatca tggtgatacc     1620

ctatcccttc agtatggtgg ttctcaactt gttcatcgtg tgaaaaccta cagaaagata     1680

gcaccatgga cccagcactc caaagacatc atgcaaaccc tgtctagata ttacagcaat     1740

gctttttcag atgccgatag acaagattcc attaatctct tcctgggagt tttccatccc     1800

actgaaggga aacctcatct ctgggagctc ccaacagatt tttatttgca tcacaaaaat     1860

accatgagac ttttgccaac aagaagaagt tatacttact ggtggacacc agaggtgata     1920

aagcatttac cattgcccta tgatgaagtt atctgtgctg tgaacttaaa gaagttgata     1980

gtgaagaaat tccacaaata tgaagaagag attgatatcc acaatgagtt ctttcggcca     2040

tatgagttga gcagctttga tgataccttt tgcttggcta tgacaagctc agcacgtgac     2100

tttatgccta agaccgttgg aattgatcca agtccattta ctgtgcgtaa accagatgaa     2160

actggaaaat cagtattggg aaacaaaagc aatagagaag aagctgtatt acagcggaaa     2220

acggcagcca gcgccccgcc gccccccagc gaggaggctg tgtccagcag ctctgaggat     2280

gactctggga ctgatcggga agaagagggc tctgtgtctc agcgctccac tcccgtgaag     2340

atgactgatg caggagacag tgccaaagtg accgagaatg tggtccaacc catgaaggag     2400

ctatatggaa ttaacctctc agatggcctc tcagaagaag atttctccat ttattcaaga     2460

tttgttcagc tggggcagag tcaacataaa caagacaaga atagccagca gccctgttct     2520

aggtgctcag atggagttat aaaactaaca cccatctcgg ctttctcgca agataacatc     2580

tatgaagttc agcccccaag agtagacaga aaatctacag agatcttcca agcccacatc     2640

caggccagcc aaggtatcat gcagccccta ggaaaagagg actcctccat gtaccgagag     2700

tacatcagga accgctacct gtga                                            2724


<210>  21
<211>  1869
<212>  DNA
<213>  Homo sapiens;

<400>  21
atgggtttgt atggacaggc ttgtccatct gtaacttcat taaggatgac atctgaactg       60

gagagcagcc taacgtctat ggactggtta ccacagctca ccatgagagc agccatccaa      120

aaatctgatg ctacacaaaa tgcacatgga acaggaattt ctaagaagaa tgcactcctt      180

gacccaaata caactctgga ccaggaagaa gtccaacagc acaaagatgg gaaacctcca      240

tacagttatg ccagcctcat tacatttgca attaatagct cacccaaaaa gaaaatgact      300

ttaagtgaaa tttatcagtg gatttgtgat aacttcccat attatagaga ggctggcagt      360

ggttggaaga attccatacg acataatctg tcattgaaca aatgtttcct taaagtgcct      420

cgatctaagg atgaccctgg aaaggggtcc tactgggcaa tagacaccaa tccgaaggaa      480

gatgtgctgc ctactcggcc aaagaagagg gcacgatctg tagaacgggc ctcaactcca      540

tatagcatag attcagattc tttgggaatg gagtgtatta tttcgggaag tgcctctcca      600

actctggcaa tcaacactgt gactaacaaa gtaacattgt ataacactga tcaggatggt      660

agtgatagcc cacgcagtag ccttaacaac agtctctcag accagagttt ggcatctgtt      720

aatttgaaca gtgttggaag tgtgcatagt tatacaccgg tgacaagcca tccagaatca      780

gtctctcaat cattaactcc tcagcagcaa ccacagtaca accttccaga aagagacaag      840

caactacttt tctcagaata taattttgaa gatcttagtg cctcatttcg gagcctttat      900

aagtcagttt ttgagcagtc acttagtcaa caaggtttga tgaacatccc ttctgaatct      960

tcccagcagt cccacacttc atgtacctat cagcactctc ccagcagtac agtgagcact     1020

cacccacaca gcaaccaaag cagcctgtcc aacagtcatg gcagtggcct caacaccaca     1080

ggcagtaatt cggttgcaca ggtctcactg tctcaccccc agatgcacac acagccatct     1140

ccacatcctc cccatcgacc gcatggttta ccgcagcatc cgcagcgttc cccacaccca     1200

gcaccacacc cacagcaaca cagccagctc cagtcccctc acccccagca tccctctcca     1260

catcaacaca tacagcacca tccgaaccat cagcatcaga cgttaacaca tcaggcaccc     1320

ccacccccac aacaggtatc ctgtaattct ggtgtttcaa atgattggta tgcgacactt     1380

gatatgctaa aagaaagctg tcgaattgcc agcagtgtta attggtcaga tgtagacctt     1440

tcacagtttc aaggtctgat ggagagtatg agacaggcag atctcaagaa ctggtcttta     1500

gaccaggttc agtttgccga tctttgttct tctcttaatc agttctttac acaaactggc     1560

cttatacatt cacagagtaa tgttcaacaa aatgtttgtc atggtgccat gcatccaaca     1620

aaaccttccc aacacattgg aacaggaaat ttgtacatag attctaggca aaatctccct     1680

ccttcagtga tgccaccccc tggttatcct catatcccac aggcactcag cactccagga     1740

acaacgatgg caggccatca cagagccatg aaccagcagc acatgatgcc ttcccaagcc     1800

ttccagatgc ggcgttccct gcctccagat gacatccagg atgactttga ttgggattca     1860

attgtgtag                                                             1869


<210>  22
<211>  1917
<212>  DNA
<213>  Homo sapiens;

<400>  22
atgagcggtg acccagatgt tctggaatac tacaagaacg atcactccaa gaagcctctg       60

cggatcatca acctgaactt ctgtgagcag gtagatgcag gcctgacctt taacaagaag      120

gagctgcagg atagttttgt gtttgacatc aagaccagtg aacgcacctt ttacctggtg      180

gctgagacag aagaggacat gaataagtgg gtccagagca tctgccagat ctgtggcttc      240

aatcaggctg aggagagcac agactccctg agaaatgttt cctcagccgg tcatggcccc      300

cgctcttctc cagctgagct cagcagctct agccagcacc ttctccgaga gcgcaagtcc      360

tcagccccat cacactccag ccagccaact ctgttcacgt ttgaaccccc tgtgtcaaac      420

cacatgcagc ccaccttgtc caccagcgca cctcaggagt atctctactt gcaccagtgc      480

ataagccgaa gagcagaaaa tgcaaggagt gccagcttct ctcagggcac cagagcctct      540

tttctcatga ggagtgacac agctgtacaa aaacttgccc agggcaatgg acactgtgtc      600

aacgggatca gtggtcaagt ccatggcttc tatagccttc ccaagccgag ccggcacaat      660

acagaattca gagacagtac ctacgacctc ccccgcagcc tggcctccca tggccacacc      720

aagggcagcc tcacaggctc cgagacagat aatgaggatg tgtacacctt caagacgccc      780

agcaacaccc tgtgcaggga gttcggggac ctcctggtag acaatatgga tgttccggcc      840

accccactct cagcctacca gatccctagg acattcactc tggacaaaaa ccacaatgcc      900

atgacagtgg ccactcctgg ggactcagcc atagctcccc caccccgccc ccccaagcca      960

agtcaggcag aaacacctcg atggggcagt cctcagcaga gaccgccaat cagtgaaaat     1020

agcagatctg tcgctgccac catccccaga cgcaacaccc tccctgcaat ggacaacagc     1080

cgacttcacc gagcttcttc ctgtgagacc tacgagtacc cacagcgtgg tggagagagt     1140

gcaggccggt ctgctgaatc catgagtgat ggagttggct ctttcctgcc agggaaaatg     1200

attgtgggcc gatcggacag caccaattct gaagacaact atgtgcccat gaatccaggt     1260

tcttccaccc tgttggccat ggaacgagca ggtgataatt cccagagcgt ctacatccca     1320

atgagcccag gggcccatca ctttgactca cttggctacc catcaacaac ccttcctgtg     1380

caccgaggcc ccagcagagg aagtgagatt cagccacccc ctgtcaaccg caacctcaaa     1440

cctgatcgga aagcaaagcc aacaccactt gacctgagga acaacaccgt catcgatgaa     1500

ctccccttca agtcacctat caccaagtct tggtctaggg ccaaccacac cttcaactcc     1560

agctcctccc agtactgccg ccccatctcc acccagagca tcaccagcac agactcagga     1620

gacagcgaag agaactatgt ccctatgcaa aacccagtgt ctgcatctcc cgttcccagt     1680

ggcacgaaca gtcctgcccc taagaagagc accggcagcg ttgattatct ggccctggac     1740

ttccagccga gctccccaag cccccaccgc aagccatcta cttcatccgt cacctctgat     1800

gagaaggtgg actacgttca ggtggacaag gagaagaccc aggccctgca gaacaccatg     1860

caggagtgga cagacgtgcg gcagtcctca gagccttcca agggtgccaa gctgtga        1917


<210>  23
<211>  1716
<212>  DNA
<213>  Homo sapiens;

<400>  23
atgcggcggc gctcgcggat gctgctctgc ttcgccttcc tgtgggtgct gggcatcgcc       60

tactacatgt actcgggggg cggctctgcg ctggccgggg gcgcgggcgg cggcgccggc      120

aggaaggagg actggaatga aattgacccc attaaaaaga aagaccttca tcacagcaat      180

ggagaagaga aagcacaaag catggagacc ctccctccag ggaaagtacg gtggccagac      240

tttaaccagg aagcttatgt tggagggacg atggtccgct ccgggcagga cccttacgcc      300

cgcaacaagt tcaaccaggt ggagagtgat aagcttcgaa tggacagagc catccctgac      360

acccggcatg accagtgtca gcggaagcag tggcgggtgg atctgccggc caccagcgtg      420

gtgatcacgt ttcacaatga agccaggtcg gccctactca ggaccgtggt cagcgtgctt      480

aagaaaagcc cgccccatct cataaaagaa atcatcttgg tggatgacta cagcaatgat      540

cctgaggacg gggctctctt ggggaaaatt gagaaagtgc gagttcttag aaatgatcga      600

cgagaaggcc tcatgcgctc acgggttcgg ggggccgatg ctgcccaagc caaggtcctg      660

accttcctgg acagtcactg cgagtgtaat gagcactggc tggagcccct cctggaaagg      720

gtggcggagg acaggactcg ggttgtgtca cccatcatcg atgtcattaa tatggacaac      780

tttcagtatg tgggggcatc tgctgacttg aagggcggtt ttgattggaa cttggtattc      840

aagtgggatt acatgacgcc tgagcagaga aggtcccggc aggggaaccc agtcgcccct      900

ataaaaaccc ccatgattgc tggtgggctg tttgtgatgg ataagttcta ttttgaagaa      960

ctggggaagt acgacatgat gatggatgtg tggggaggag agaacctaga gatctcgttc     1020

cgcgtgtggc agtgtggtgg cagcctggag atcatcccgt gcagccgtgt gggacacgtg     1080

ttccggaagc agcaccccta cacgttcccg ggtggcagtg gcactgtctt tgcccgaaac     1140

acccgccggg cagcagaggt ctggatggat gaatacaaaa atttctatta tgcagcagtg     1200

ccttctgcta gaaacgttcc ttatggaaat attcagagca gattggagct taggaagaaa     1260

ctcagctgca agcctttcaa atggtacctt gaaaatgtct atccagagtt aagggttcca     1320

gaccatcagg atatagcttt tggggccttg cagcagggaa ctaactgcct cgacactttg     1380

ggacactttg ctgatggtgt ggttggagtt tatgaatgtc acaatgctgg gggaaaccag     1440

gaatgggcct tgacgaagga gaagtcggtg aagcacatgg atttgtgcct tactgtggtg     1500

gaccgggcac cgggctctct tataaagctg cagggctgcc gagaaaatga cagcagacag     1560

aaatgggaac agatcgaggg caactccaag ctgaggcacg tgggcagcaa cctgtgcctg     1620

gacagtcgca cggccaagag cgggggccta agcgtggagg tgtgtggccc ggccctttcg     1680

cagcagtgga agttcacgct caacctgcag cagtag                               1716


<210>  24
<211>  1011
<212>  DNA
<213>  Homo sapiens;

<400>  24
atgtccaata tggagaacag ctttgacgat gtttcttgcc tctctcccca gaacctggga       60

tcctcatcgc caagcaaaaa gcagagcaag gaaaacacca tcacaataaa ctgtgtgacg      120

ttccctcacc cagacacgat gccggaacag cagctgctga aaccaaccga gtggagctac      180

tgcgactact tctgggctga taagaaggac ccccaaggca acggcaccgt ggctgggttt      240

gaactactgc tccagaaaca gctgaagggc aaacaaatgc agaaggaaat gtcagaattc      300

atccgggaaa ggataaagat tgaagaagac tatgcgaaga acttagctaa gctctctcag      360

aactccttgg cttcacagga ggaaggctcc ttgggagagg cgtgggccca ggtgaagaag      420

agcctggcgg acgaagcaga agttcacctc aagttctctg ccaagcttca cagcgaggtg      480

gagaagcccc tgatgaactt ccgtgagaac ttcaagaaag acatgaagaa gtgcgaccac      540

cacattgccg accttcgcaa gcagctcgcc agccgctatg cctcggtgga gaaggcccgg      600

aaagccctca cagagcggca gagagacctg gagatgaaga cccagcagct ggagatcaag      660

ctgagcaaca agacagagga ggacatcaag aaggcgcgga gaaagtccac acaggctgga      720

gacgacctca tgcgctgtgt ggatctctac aaccaggccc agtccaaatg gtttgaagag      780

atggtgacca ccacattgga gctagagcgg ctggaggtgg agagggtaga gatgatccgg      840

cagcacctgt gccagtacac gcagctgcgg catgaaacag acatgttcaa ccaaagcaca      900

gtcgagcccg tggatcagct gcttcgaaaa gtggacccgg ccaaagacag ggagctgtgg      960

gtcagagagc acaagacggg caacatccgc cctgtggaca tggagatcta g              1011


<210>  25
<211>  5055
<212>  DNA
<213>  Homo sapiens;

<400>  25
atggaggatc ttgttcaaga tggggtggct tcaccagcta cccctgggac cgggaaatct       60

aagctggaaa cattgcccaa agaagacctc atcaagtttg ccaagaaaca gatgatgcta      120

atacagaaag ctaaatcaag gtgtacagaa ttggagaaag aaattgaaga actcagatca      180

aaacctgtta ctgaaggaac tggtgatatt attaaggcat taactgaacg tctggatgct      240

cttcttctgg aaaaagcaga gactgagcaa cagtgtcttt ctctgaaaaa ggaaaatata      300

aaaatgaagc aagaggttga ggattctgta acaaagatgg gagatgcaca taaggagttg      360

gaacaatcac atataaacta tgtgaaagaa attgaaaatt tgaaaaatga gttgatggca      420

gtacgttcca aatacagtga agacaaagct aacttacaaa agcagctgga agaagcaatg      480

aatacgcaat tagaactttc agaacaactt aaatttcaga acaactctga agataatgtt      540

aaaaaactac aagaagagat tgagaaaatt aggccaggct ttgaggagca aattttatat      600

ctgcaaaagc aattagacgc taccactgat gaaaagaagg aaacagttac tcaactccaa      660

aatatcattg aggctaattc tcagcattac caaaaaaata ttaatagttt gcaggaagag      720

cttttacagt tgaaagctat acaccaagaa gaggtgaaag agttgatgtg ccagattgaa      780

gcatcagcta aggaacatga agcagagata aataagttga acgagctaaa agagaactta      840

gtaaaacaat gtgaggcaag tgaaaagaac atccagaaga aatatgaatg tgagttagaa      900

aatttaagga aagccacctc aaatgcaaac caagacaatc agatatgttc tattctcttg      960

caagaaaata catttgtaga acaagtagta aatgaaaaag tcaaacactt agaagatacc     1020

ttaaaagaac ttgaatctca acacagtatc ttaaaagatg aggtaactta tatgaataat     1080

cttaagttaa aacttgaaat ggatgctcaa catataaagg atgagttttt tcatgaacgg     1140

gaagacttag agtttaaaat taatgaatta ttactagcta aagaagaaca gggctgtgta     1200

attgaaaaat taaaatctga gctagcaggt ttaaataaac agttttgcta tactgtagaa     1260

cagcataaca gagaagtaca gagtcttaag gaacaacatc aaaaagaaat atcagaacta     1320

aatgagacat ttttgtcaga ttcagaaaaa gaaaaattaa cattaatgtt tgaaatacag     1380

ggtcttaagg aacagtgtga aaacctacag caagaaaagc aagaagcaat tttaaattat     1440

gagagtttac gagagattat ggaaatttta caaacagaac tgggggaatc tgctggaaaa     1500

ataagtcaag agttcgaatc aatgaagcaa cagcaagcat ctgatgttca tgaactgcag     1560

cagaagctca gaactgcttt tactgaaaaa gatgcccttc tcgaaactgt gaatcgcctc     1620

cagggagaaa atgaaaagtt actatctcaa caagaattgg taccagaact tgaaaatacc     1680

ataaagaacc ttcaagaaaa gaatggagta tacttactta gtctcagtca aagagatacc     1740

atgttaaaag aattagaagg aaagataaat tctcttactg aggaaaaaga tgattttata     1800

aataaactga aaaattccca tgaagaaatg gataatttcc ataagaaatg tgaaagggaa     1860

gaaagattga ttcttgaact tgggaagaaa gtagagcaaa caatccagta caacagtgaa     1920

ctagaacaaa aggtaaatga attaacagga ggactagagg agactttaaa agaaaaggat     1980

caaaatgacc aaaaactaga aaaacttatg gttcaaatga aagttctctc tgaagacaaa     2040

gaagtattgt cagctgaagt gaagtctctt tatgaggaaa acaataaact cagttcagaa     2100

aaaaaacagt tgagtaggga tttggaggtt tttttgtctc aaaaagaaga tgttatcctt     2160

aaagaacata ttactcaatt agaaaagaaa cttcagttaa tggttgaaga gcaagataat     2220

ttaaataaac tgcttgaaaa tgagcaagtt cagaagttat ttgttaaaac tcagttgtat     2280

ggttttctta aagaaatggg atcagaagtt tcagaagaca gtgaagagaa agatgttgtt     2340

aatgtcctac aggcagtcgg tgaatccttg gcaaaaataa atgaggaaaa atgcaacctg     2400

gcttttcagc gtgatgaaaa agtattagag ttagaaaaag agattaagtg ccttcaagaa     2460

gagagtgtag ttcagtgtga agaacttaag tctttattga gagactatga gcaagagaaa     2520

gttctcttaa ggaaagagtt agaagaaata cagtcagaaa aagaggccct gcagtctgat     2580

cttctagaaa tgaagaatgc taatgaaaaa acaaggcttg aaaatcagaa tcttttaatt     2640

caagttgaag aagtatctca aacatgtagc aaaagtgaaa tccataatga aaaagaaaaa     2700

tgttttataa aggaacatga aaacctaaag ccactactag aacaaaaaga attacgagat     2760

aggagagcag agttgatact attaaaggat tccttagcaa aatcaccttc tgtaaaaaat     2820

gatcctctgt cttcagtaaa agagttggaa gaaaaaatag aaaatctgga aaaagaatgc     2880

aaagaaaagg aggagaaaat aaataagata aaattagttg ccgtaaaggc aaagaaagaa     2940

ctagattcca gcagaaaaga gacccagact gtgaaggaag aacttgaatc tcttcgatca     3000

gaaaaggacc agttatctgc ttccatgaga gatctcattc aaggagcaga aagctataag     3060

aatcttttat tagaatatga aaagcagtca gagcaactgg atgtggaaaa agaacgtgct     3120

aataattttg agcatcgtat tgaagacctt acaagacaat taagaaattc gactttgcag     3180

tgtgaaacaa taaattctga taatgaagat ctcctggctc gtattgagac attacagtct     3240

aatgccaaat tattagaagt acagatttta gaagtccaga gagccaaagc aatggtagac     3300

aaagaattag aagctgaaaa acttcagaaa gaacagaaga taaaggaaca tgccactact     3360

gtaaatgaac ttgaagaact tcaggtacaa cttcaaaagc aaaagaaaca gcttcagaaa     3420

accatgcaag aattagagct ggttaaaaag gatgcccaac aaaccacatt gatgaatatg     3480

gaaatagctg attatgaacg tttgatgaaa gaactaaatc aaaagttaac taataaaaac     3540

aacaagatag aagatttgga gcaagaaata aaaattcaaa aacagaaaca agaaacccta     3600

caagaagaaa taacttcatt acagtcttca gtacaacaat atgaagaaaa aaacaccaaa     3660

atcaagcaat tgcttgtgaa aaccaaaaag gaactggcag attcaaagca agcagaaact     3720

gatcacttaa tacttcaagc atctttaaaa ggtgagctgg aggcaagcca gcagcaagta     3780

gaagtctata aaatacagct ggctgaaata acatcagaga agcacaaaat ccacgagcac     3840

ctgaaaacct ctgcggaaca gcaccagcgt acgctaagtg cataccagca gagagtgaca     3900

gcactacagg aagagtgccg tgctgccaag gcagaacaag ctactgtaac ctctgaattc     3960

gagagctaca aagtccgagt tcataatgtt ctaaaacaac agaaaaataa atctatgtct     4020

caggctgaaa ctgagggcgc taaacaagaa agggaacatc tggaaatgct gattgaccag     4080

ctaaaaatca aattacaaga tagccaaaat aacttacaga ttaatgtatc tgaacttcaa     4140

acattgcagt ctgaacatga tacactgcta gaaaggcaca acaagatgct gcaggaaact     4200

gtgtccaaag aggcggaact ccgggaaaaa ttgtgttcaa tacagtcaga gaacatgatg     4260

atgaaatctg aacatacaca gactgtgagt cagctaacat cccagaacga ggtccttcga     4320

aatagcttcc gagatcaagt gcgacatttg caggaagaac acagaaagac agtggagaca     4380

ttacagcagc agctctccaa gatggaagca cagctcttcc agcttaagaa tgaaccgacc     4440

acaagaagcc cagtttcctc tcaacaatct ttgaagaacc ttcgagaaag gagaaacaca     4500

gacctcccgc ttctagacat gcacactgta acccgggaag agggagaagg catggagaca     4560

actgatacgg agtctgtgtc ttccgccagc acatacacac agtctttaga gcagctgctt     4620

aactctcccg aaactaaact tgagcctcca ttatggcatg ctgaatttac caaagaagaa     4680

ttggttcaga agctcagttc caccacaaaa agtgcagatc acttaaacgg cctgcttcgg     4740

gaaacagaag caaccaatgc aattcttatg gagcaaatta agcttctcaa aagtgaaata     4800

agaagattgg aaaggaatca agagcgagag aagtctgcag ctaacctgga atacttgaag     4860

aacgtcttgc tgcagttcat tttcttgaaa ccaggtagtg aaagagagag acttcttcct     4920

gttataaata cgatgttgca gctcagccct gaagaaaagg gaaaacttgc tgcggttgct     4980

caaggtgagg aagaaaatgc ttcccgttct tctggatggg catcctatct tcatagttgg     5040

tctggacttc gatag                                                      5055


<210>  26
<211>  1773
<212>  DNA
<213>  Homo sapiens;

<400>  26
atggagctgg aaaacatcgt ggccaacacg gtcttgctga aagccaggga agggggcgga       60

ggaaagcgca aagggaaaag caagaagtgg aaagaaatcc tgaagttccc tcacattagc      120

cagtgtgaag acctccgaag gaccatagac agagattact gcagtttatg tgacaagcag      180

ccaatcggga ggctgctttt ccggcagttt tgtgaaacca ggcctgggct ggagtgttac      240

attcagttcc tggactccgt ggcagaatat gaagttactc cagatgaaaa actgggagag      300

aaagggaagg aaattatgac caagtacctc accccaaagt cccctgtttt catagcccaa      360

gttggccaag acctggtctc ccagacggag gagaagctcc tacagaagcc gtgcaaagaa      420

ctcttttctg cctgtgcaca gtctgtccac gagtacctga ggggagaacc attccacgaa      480

tatctggaca gcatgttttt tgaccgcttt ctccagtgga agtggttgga aaggcaaccg      540

gtgaccaaaa acactttcag gcagtatcga gtgctaggaa aagggggctt cggggaggtc      600

tgtgcctgcc aggttcgggc cacgggtaaa atgtatgcct gcaagcgctt ggagaagaag      660

aggatcaaaa agaggaaagg ggagtccatg gccctcaatg agaagcagat cctcgagaag      720

gtcaacagtc agtttgtggt caacctggcc tatgcctacg agaccaagga tgcactgtgc      780

ttggtcctga ccatcatgaa tgggggtgac ctgaagttcc acatctacaa catgggcaac      840

cctggcttcg aggaggagcg ggccttgttt tatgcggcag agatcctctg cggcttagaa      900

gacctccacc gtgagaacac cgtctaccga gatctgaaac ctgaaaacat cctgttagat      960

gattatggcc acattaggat ctcagacctg ggcttggctg tgaagatccc cgagggagac     1020

ctgatccgcg gccgggtggg cactgttggc tacatggctc cagaggtcct gaacaaccag     1080

aggtacggcc tgagccccga ctactggggc cttggctgcc tcatctatga gatgatcgag     1140

ggccagtcgc cgttccgcgg ccgcaaggag aaggtgaagc gggaggaggt ggaccgccgg     1200

gtcctggaga cggaggaggt gtactcccac aagttctccg aggaggccaa gtccatctgc     1260

aagatgctgc tcacgaaaga tgcgaagcag aggctgggct gccaggagga gggggctgca     1320

gaggtcaaga gacacccctt cttcaggaac atgaacttca agcgcttaga agccgggatg     1380

ttggaccctc ccttcgttcc agacccccgc gctgtgtact gtaaggacgt gctggacatc     1440

gagcagttct ccactgtgaa gggcgtcaat ctggaccaca cagacgacga cttctactcc     1500

aagttctcca cgggctctgt gtccatccca tggcaaaacg agatgataga aacagaatgc     1560

tttaaggagc tgaacgtgtt tggacctaat ggtaccctcc cgccagatct gaacagaaac     1620

caccctccgg aaccgcccaa gaaagggctg ctccagagac tcttcaagcg gcagcatcag     1680

aacaattcca agagttcgcc cagctccaag accagtttta accaccacat aaactcaaac     1740

catgtcagct cgaactccac cggaagcagc tag                                  1773


<210>  27
<211>  1974
<212>  DNA
<213>  Homo sapiens;

<400>  27
atgcccagat acacggtgca cgtacgtggg gaatggctgg cagtgccctg ccaggacgcg       60

cagctcactg tgggctggct gggccgggag gccgtgaggc gctatatcaa gaataagccc      120

gacaatggtg gcttcacctc cgtggatgac gcgcacttcc ttgtgcgccg gtgcaagggc      180

ctgggcctgc tggacaacga ggaccggctc gaggtggccc tagagaacaa cgagttcgtg      240

gaagtggtta tagagggtga tgccatgtct cctgacttca ttccatctca accagaagga      300

gtttatctat acagcaagta ccgggagcct gaaaagtaca tcgagttaga tggagaccgt      360

ctgaccacgg aggatctggt caacttggga aagggacgct acaaaataaa gctcacccca      420

acagctgaga agagggtgca gaaatccagg gaggtcatag atagcatcat aaaagagaaa      480

acagttgttt acggtattac tacaggtttt gggaaatttg ccagaactgt aattcctatc      540

aataagctac aggagcttca ggtcaactta gtacgctcac attcttcagg tgttgggaaa      600

ccactaagtc ctgagaggtg tcggatgctc ttggctttaa ggatcaatgt cttagccaaa      660

ggatacagtg gcatttccct ggagaccctc aaacaagtca tagaaatgtt taatgcctcc      720

tgcctgccct atgtcccaga gaaaggaacc gttggtgcca gtggagacct tgccccactc      780

tctcatcttg ctcttgggct agttggagaa gggaagatgt ggtctccgaa gagtggctgg      840

gctgatgcta aatacgtgct agaagcccat ggattgaaac cagttatttt aaaaccaaaa      900

gagggcctgg cactcatcaa tgggacgcag atgatcacat ccctgggctg tgaagctgta      960

gagcgagcca gtgctattgc acggcaggct gacattgtgg cagccctgac ccttgaggtg     1020

ctgaagggca ccaccaaagc ctttgacact gacattcatg ctcttcgacc tcaccgtggg     1080

caaattgaag ttgcttttcg gtttcggtca ctcttggact cagatcacca cccatcagaa     1140

atagcagaga gtcacaggtt ctgtgatcgc gtccaggatg catacacctt gcgctgctgt     1200

ccacaggtcc atggtgtggt gaatgataca atagcatttg tgaagaacat cattaccaca     1260

gaactgaaca gcgcaacaga taatcctatg gtctttgcca ataggggaga gacagtttct     1320

ggaggaaact tccatggtga atacccagcc aaagccctag actacttggc cattggcatc     1380

catgaacttg ctgcaatcag tgagagaaga atcgagcggc tctgcaatcc ctccctcagt     1440

gagctgcctg ccttcctggt ggctgaaggt ggtctgaact ctgggttcat gatagctcac     1500

tgcacggcag cagcccttgt ttctgagaac aaggctctgt gccatccctc gtctgttgac     1560

tccctctcca ccagcgcagc cacggaggac cacgtctcca tgggaggatg ggcagcaagg     1620

aaagccctca gggtcatcga gcatgtggag caagtgctgg ccatcgagct ccttgcagcc     1680

tgccagggca tagagtttct acgtcccctg aaaacaacca ctccgctgga gaaggtctat     1740

gacctggtgc gctctgttgt aaggccctgg ataaaagatc gcttcatggc cccggacatc     1800

gaggcagccc acaggctgct cctggagcag aaggtttggg aagtagctgc tccatacatt     1860

gaaaaataca gaatggagca tattccagaa tcaagacctc tttctccaac agccttttca     1920

ctgcaatttc tgcacaagaa atccaccaaa atcccggagt ctgaggacct ttaa           1974


<210>  28
<211>  1461
<212>  DNA
<213>  Homo sapiens;

<400>  28
atgtggaagt ctgtagtggg ccatgatgtg tctgtttccg tggagaccca gggtgatgat       60

tgggacacag atcctgactt tgtgaatgac atctctgaaa aggagcaacg atggggagcc      120

aagaccatcg aggggtctgg acgcacagaa cacatcaaca tccaccagct gaggaacaaa      180

gtatcagagg agcatgatgt tctcaggaag aaagagatgg agtcagggcc caaagcatcc      240

catggctatg gaggtcggtt tggagtagaa agagaccgaa tggacaagag tgcagtgggc      300

catgagtatg ttgccgaggt ggagaagcac tcttctcaga cggatgctgc caaaggcttt      360

gggggcaagt acggagttga gagggacagg gcagacaagt cagcagtcgg ctttgattat      420

aaaggagaag tggagaagca cacatctcag aaagattact ctcgtggctt tggtggccgg      480

tacggggtgg agaaggataa atgggacaaa gcagctctgg gatatgacta caagggagag      540

acggagaaac acgagtccca gagagattat gccaagggct ttggtggcca gtatggaatc      600

cagaaggacc gagtggataa gagcgctgtc ggcttcaatg aaatggaggc cccgaccaca      660

gcttataaga agacgacgcc catagaagcc gcttctagtg gtacccgtgg gctgaaggcg      720

aaatttgagt ccatggctga ggagaagagg aagcgagagg aagaggagaa ggcacagcag      780

gtggccagga ggcaacagga gcgaaaggct gtgacaaaga ggagccctga ggctccacag      840

ccagtgatag ctatggaaga gccagcagta ccggccccac tgcccaagaa aatctcctca      900

gaggcctggc ctccagttgg gactcctcca tcatcagagt ctgagcctgt gagaaccagc      960

agggaacacc cagtgccctt gctgcccatt aggcagactc tcccggagga caatgaggag     1020

cccccagctc tgccccctag gactctggaa ggcctccagg tggaggaaga gccagtgtac     1080

gaagcagagc ctgagcctga gcccgagcct gagcccgagc ctgagaatga ctatgaggac     1140

gttgaggaga tggacaggca tgagcaggag gatgaaccag agggggacta tgaggaggtg     1200

ctcgagcctg aagattcttc tttttcttct gctctggctg gatcatcagg ctgcccggct     1260

ggggctgggg ctggggctgt ggctctgggg atctcagctg tggctgtata tgattaccaa     1320

ggagagggaa gtgatgagct ttcctttgat ccggacgacg taatcactga cattgagatg     1380

gtggacgagg gctggtggcg gggacgttgc catggccact ttggactctt ccctgcaaat     1440

tatgtcaagc ttctggagtg a                                               1461


<210>  29
<211>  2772
<212>  DNA
<213>  Homo sapiens;

<400>  29
atggactcca ttgggtcttc agggttgcgg cagggggaag aaaccctgag ttgctctgag       60

gagggcttgc ccgggccctc agacagctca gagctggtgc aggagtgcct gcagcagttc      120

aaggtgacaa gggcacagct acagcagatc caagccagcc tcttgggttc catggagcag      180

gcgctgaggg gacaggccag ccctgcccct gcggtccgga tgctgcctac atacgtgggg      240

tccaccccac atggcactga gcaaggagac ttcgtggtgc tggagctggg ggccacaggg      300

gcctcactgc gtgttttgtg ggtgactcta actggcattg aggggcatag ggtggagccc      360

agaagccagg agtttgtgat cccccaagag gtgatgctgg gtgctggcca gcagctcttt      420

gactttgctg cccactgcct gtctgagttc ctggatgcgc agcctgtgaa caaacagggt      480

ctgcagcttg gcttcagctt ctctttccct tgtcaccaga cgggcttgga caggagcacc      540

ctcatttcct ggaccaaagg ttttaggtgc agtggtgtgg aaggccagga tgtggtccag      600

ctgctgagag atgccattcg gaggcagggg gcctacaaca tcgacgtggt tgctgtggtg      660

aacgacacag tgggcaccat gatgggctgt gagccggggg tcaggccgtg tgaggttggg      720

ctagttgtag acacgggcac caacgcgtgt tacatggagg aggcacggca tgtggcagtg      780

ctggacgaag accggggccg cgtctgcgtc agcgtcgagt ggggctcctt cagcgatgat      840

ggggcgctgg gaccagtgct gaccaccttc gaccataccc tggaccatga gtccctgaat      900

cctggtgctc agaggtttga gaagatgatc ggaggcctgt acctgggtga gctggtgcgg      960

ctggtgctgg ctcacttggc ccggtgtggg gtcctctttg gtggctgcac ctcccctgcc     1020

ctgctgagcc aaggcagcat cctcctggaa cacgtggctg agatggagga cccctctact     1080

ggggcagccc gtgtccatgc tatcctgcag gacttgggcc tgagccctgg ggcttcggat     1140

gttgagcttg tgcagcacgt ctgtgcggcc gtgtgcacgc gggctgccca gctctgtgct     1200

gccgccctgg ccgctgttct ctcctgcctc cagcacagcc gggagcaaca aacactccag     1260

gttgctgtgg ccaccggagg ccgagtgtgt gagcggcacc ccaggttctg cagcgtcctg     1320

caggggacag tgatgctcct ggccccggaa tgcgatgtct ccttaatccc ctctgtggat     1380

ggtggtggcc ggggagtggc gatggtgact gccgtggctg cccgtctggc tgcccaccgg     1440

cgcctgctgg aggagaccct ggccccattc cggttgaacc atgatcaact ggctgcggtt     1500

caggcacaga tgcggaaggc catggccaag gggctccgag gggaggcctc ctcccttcgc     1560

atgctgccca ctttcgtccg ggccacccct gacggcagcg agcgagggga tttcctggcc     1620

ctggacctcg ggggcacgaa cttccgtgtc ctcctggtac gtgtgaccac aggcgtgcag     1680

atcaccagcg agatctactc cattcccgag actgtggccc agggttctgg gcagcagctc     1740

tttgaccaca tcgtggactg catcgtggac ttccagcaga agcagggcct gagcgggcag     1800

agcctcccac tgggttttac cttctccttc ccatgtaggc agcttggcct agaccagggc     1860

atcctcctga actggaccaa gggtttcaag gcatcagact gcgagggcca agatgtcgtg     1920

agtctgttgc gggaagccat cactcgcaga caggcagtgg agctgaatgt ggttgccatt     1980

gtcaatgaca cggtggggac catgatgtcc tgtggctatg aggacccccg ttgcgagata     2040

ggcctcattg tcggaaccgg caccaatgcc tgctacatgg aggagctccg gaatgtggcg     2100

ggcgtgcctg gggactcagg ccgcatgtgc atcaacatgg agtggggcgc ctttggggac     2160

gatggctctc tggccatgct cagcacccgc tttgatgcaa gtgtggacca ggcgtccatc     2220

aaccccggca agcagaggtt tgaaaagatg atcagcggca tgtacctggg ggagatcgtc     2280

cgccacatcc ttttacattt aaccagcctt ggcgttctct tccggggcca gcagatccag     2340

cgccttcaga ccagggacat cttcaagacc aagttcctct ctgagatcga aagtgacagc     2400

ctggccctgc ggcaggtccg agccatccta gaggatctgg ggctacccct gacctcagat     2460

gacgccctga tggtgctaga ggtgtgccag gctgtgtccc agagggctgc ccagctctgt     2520

ggggcgggtg tagctgccgt ggtggagaag atccgggaga accggggcct ggaagagctg     2580

gcagtgtctg tgggggtgga tggaacgctc tacaagctgc acccgcgctt ctccagcctg     2640

gtggcggcca cagtgcggga gctggcccct cgctgtgtgg tcacgttcct gcagtcagag     2700

gatgggtccg gcaaaggtgc ggccctggtc accgctgttg cctgccgcct tgcgcagttg     2760

actcgtgtct ga                                                         2772


<210>  30
<211>  1899
<212>  DNA
<213>  Homo sapiens;

<400>  30
atgaatagat acacaacaat caggcagctc ggggatggaa cctacggttc cgtcctgctg       60

ggaagaagca ttgagtctgg ggagctgatc gctattaaaa aaatgaaaag aaaattttat      120

tcctgggagg aatgcatgaa ccttcgggag gttaagtctt taaagaagct caaccatgcc      180

aatgtagtca aattaaaaga agttatcagg gaaaatgatc atctttattt tatcttcgag      240

tacatgaagg aaaatcttta ccagctcatt aaagagagaa ataagttgtt tcctgagtct      300

gctataagga atatcatgta tcagatatta caaggactcg catttattca caaacacggc      360

ttctttcatc gagacttaaa gcctgagaac ctcctctgca tgggaccaga acttgtgaaa      420

attgcagact ttggtttggc ccgagaaata cgatcaaaac ctccatatac agattatgta      480

tctaccagat ggtacagggc tccagaagta ctcctgaggt ctaccaacta cagctccccc      540

attgacgtct gggcggtggg ctgcatcatg gcagaagttt acaccctcag gccactcttc      600

cctggagcca gtgaaattga cacaatattc aaaatttgcc aagtgctggg gacaccaaaa      660

aagactgact ggcctgaagg ctatcaactt tcaagtgcaa tgaacttccg ttggccacag      720

tgtgtaccca ataacttaaa gaccttgatt cccaatgcta gcagtgaagc agtccagctc      780

ctgagagaca tgcttcagtg ggatcccaag aaacgaccaa cagctagtca ggcacttcga      840

tatccttact tccaagttgg acacccacta ggcagcacca cacaaaacct tcaggattca      900

gaaaaaccac agaaaggcat cctggaaaag gcaggcccac ctccttatat taagccagtc      960

ccacctgccc agccaccagc caagccacac acacgaattt cttcacgaca gcatcaagcc     1020

agccagcccc ctctgcatct cacgtacccc tacaaagcag aggtctccag gacagatcac     1080

ccaagccatc tccaggagga caagccaagc ccgttgcttt tcccatccct ccacaacaag     1140

catccacagt cgaaaatcac agctggcctg gagcacaaaa atggtgagat aaagccaaag     1200

agtaggagaa ggtggggtct tatttccagg tcaacaaagg attcagatga ttgggctgac     1260

ttggatgact tggatttcag tccatccctc agcaggattg acctgaaaaa caagaaaaga     1320

cagagtgatg acactctctg caggtttgag agtgttttgg acctgaagcc ctctgagcct     1380

gtgggcacag gaaacagtgc ccccacccag acgtcatatc agcggcgaga cacgcccacc     1440

ctgagatctg cagccaagca gcactatttg aagcactctc gatacttgcc tgggatcagt     1500

ataagaaatg gcatactctc gaatccaggc aaggaattta ttccacctaa tccatggtct     1560

agttctggct tgtctggaaa atcttcaggg acaatgtcag taatcagcaa agtaaattca     1620

gttggttcca gctctacaag ttctagtgga ctgactggaa actatgtccc ttcctttctg     1680

aaaaaagaaa tcggttctgc tatgcagagg gtacacctag cacctattcc agacccttcc     1740

cctggttatt cctccctgaa ggccatgaga cctcatcctg ggcgaccatt cttccacacc     1800

cagcctagaa gcactcctgg gttgatacca cggcctccag ccgcccagcc agtgcatggc     1860

cggacagact gggcttccaa gtacgcatct cggcgatga                            1899


<210>  31
<211>  849
<212>  DNA
<213>  Homo sapiens;

<400>  31
atggagcggc cgtcgctgcg cgccctgctc ctcggcgccg ctgggctgct gctcctgctc       60

ctgcccctct cctcttcctc ctcttcggac acctgcggcc cctgcgagcc ggcctcctgc      120

ccgcccctgc ccccgctggg ctgcctgctg ggcgagaccc gcgacgcgtg cggctgctgc      180

cctatgtgcg cccgcggcga gggcgagccg tgcgggggtg gcggcgccgg cagggggtac      240

tgcgcgccgg gcatggagtg cgtgaagagc cgcaagaggc ggaagggtaa agccggggca      300

gcagccggcg gtccgggtgt aagcggcgtg tgcgtgtgca agagccgcta cccggtgtgc      360

ggcagcgacg gcaccaccta cccgagcggc tgccagctgc gcgccgccag ccagagggcc      420

gagagccgcg gggagaaggc catcacccag gtcagcaagg gcacctgcga gcaaggtcct      480

tccatagtga cgccccccaa ggacatctgg aatgtcactg gtgcccaggt gtacttgagc      540

tgtgaggtca tcggaatccc gacacctgtc ctcatctgga acaaggtaaa aaggggtcac      600

tatggagttc aaaggacaga actcctgcct ggtgaccggg acaacctggc cattcagacc      660

cggggtggcc cagaaaagca tgaagtaact ggctgggtgc tggtatctcc tctaagtaag      720

gaagatgctg gagaatatga gtgccatgca tccaattccc aaggacaggc ttcagcatca      780

gcaaaaatta cagtggttga tgccttacat gaaataccag tgaaaaaagg tgaaggtgcc      840

gagctataa                                                              849


<210>  32
<211>  1674
<212>  DNA
<213>  Homo sapiens;

<400>  32
atgccggagc gagatagtga gccgttctcc aaccctttgg cccccgatgg ccacgatgtg       60

gatgatcctc actccttcca ccaatcaaaa ctcaccaatg aagacttcag gaaacttctc      120

atgaccccca gggctgcacc tacctctgca ccaccttcta agtcacgtca ccatgagatg      180

ccaagggagt acaatgagga tgaagaccca gctgcacgaa ggaggaaaaa gaaaagttat      240

tatgccaagc tacgccaaca agaaattgag agagagagag agctagcaga gaagtaccgg      300

gatcgtgcca aggaacggag agatggagtg aacaaagatt atgaagaaac cgagcttatc      360

agcaccacag ctaactatag ggctgttggc cccactgctg aggcggacaa atcagctgca      420

gagaagagaa gacagttgat ccaggagtcc aaattcttgg gtggtgacat ggaacacacc      480

catttggtga aaggcttgga ttttgctctg cttcaaaagg tacgagctga gattgccagc      540

aaagagaaag aggaagagga actgatggaa aagccccaga aagaaaccaa gaaagatgag      600

gatcctgaaa ataaaattga atttaaaaca cgtctgggcc gcaatgttta ccgaatgctt      660

tttaagagca aagcatatga gcggaatgag ttgttcctgc cgggccgcat ggcctatgtg      720

gtagacctgg atgatgagta tgctgacaca gatatcccca ccactcttat ccgcagcaag      780

gctgattgcc ccaccatgga ggcccagacc acactgacca caaatgacat tgtcattagc      840

aagctgaccc agatcctttc atacctgagg cagggaaccc gtaacaagaa gcttaagaag      900

aaggataaag ggaagctgga agagaagaaa cctcctgagg ctgacatgaa tatttttgaa      960

gacattgggg attacgtacc ctccacaacc aagacacctc gggacaagga gcgggagaga     1020

tatcgggaac gggagcgtga tcgggaaaga gacagagacc gtgaccgaga gcgagagcga     1080

gaacgagatc gggaacgaga gcgagagcgg gaccgagaga gagaagagga aaagaagaga     1140

cacagctact ttgagaagcc aaaagtagat gatgagccca tggacgttga caaaggacct     1200

gggtctacca aggagttgat caagtccatc aatgaaaagt ttgctgggtc tgctggctgg     1260

gaaggcacag aatcgctgaa gaagccagaa gacaaaaagc agctgggaga tttctttggc     1320

atgtccaaca gttatgcaga gtgctaccca gccacgatgg atgacatggc tgtggatagt     1380

gatgaggagg tggattatag caaaatggac cagggtaaca agaaggggcc cttaggccgt     1440

tgggactttg atacccagga agaatacagc gagtatatga acaacaaaga agctttgccc     1500

aaggctgcat tccagtatgg tatcaaaatg tctgaagggc ggaaaaccag gcgcttcaag     1560

gaaaccaatg acaaagcaga gcttgatcgc cagtggaaga agattagtgc aatcattgag     1620

aagaggaaga agatggaagc tgatggggtt gaagtcaaaa gaccaaaata ctaa           1674


<210>  33
<211>  1260
<212>  DNA
<213>  Homo sapiens;

<400>  33
atgggtgaaa aaaaaccaga gcctttggac ttcgtgaaag attttcagga atacctgact       60

cagcagaccc atcacgtgaa catgatttct ggatcagtta gtggggacaa agaagcagag      120

gctcttcagg gagctggaac agatggtgat caaaatggac ttgatcaccc atctgttgaa      180

gtttccttgg atgaaaactc aggaatgtta gtagacgggt ttgaaaggac ctttgatggg      240

aagcttaagt gtcggtactg caactatgcc agcaaaggaa cagcccggct tattgaacac      300

atcagaatcc acacaggtga aaaacctcat cgatgtcatc tttgtccatt tgcatctgct      360

tatgagcgtc atctggaagc ccatatgcgt tctcatactg gagaaaaacc atacaaatgt      420

gaattatgtt ccttccgctg cagtgatcga agtaacttgt cccatcatcg aaggcgcaag      480

cataaaatgg taccaattaa aggtactagg tcttccttaa gcagcaagaa aatgtggggg      540

gttttacaga agaaaacaag caatctgggc tatagcagaa gagcactaat caacttaagt      600

ccaccttcca tggtggttca gaaaccagac taccttaacg attttaccca cgaaatccca      660

aatatccaga ctgactccta tgaaagtatg gcaaaaacca caccaactgg tggccttcca      720

agggaccccc aagaactcat ggttgataac cctttgaatc agctctcgac tctagcaggg      780

cagttgtcca gtctgccacc cgaaaaccaa aaccctgcat cccctgatgt agttccctgc      840

cctgatgaaa agcctttcat gattcagcag ccctctaccc aagcagtagt ttctgccgta      900

tcagcaagta ttcctcagag ctcctctccc acaagcccag aacctcggcc atcccatagt      960

caaaggaact atagtccagt ggcaggtcca agcagtgagc caagtgccca cacgagcact     1020

cccagcatag gaaacagcca gccaagcacc ccagccccag ccctgccggt ccaggaccct     1080

cagcttctgc accactgcca gcactgtgat atgtactttg cagacaacat cctttacact     1140

attcatatgg gatgtcatgg gtatgaaaat ccttttcagt gtaatatatg tggatgcaaa     1200

tgtaaaaaca agtatgattt tgcctgtcat tttgcaagag ggcaacataa ccaacattga     1260


<210>  34
<211>  1656
<212>  DNA
<213>  Homo sapiens;

<400>  34
atggcggccc ctgctctgtc ctggcgtctg cccctcctca tcctcctcct gcccctggct       60

acctcttggg catctgcagc ggtgaatggc acttcccagt tcacatgctt ctacaactcg      120

agagccaaca tctcctgtgt ctggagccaa gatggggctc tgcaggacac ttcctgccaa      180

gtccatgcct ggccggacag acggcggtgg aaccaaacct gtgagctgct ccccgtgagt      240

caagcatcct gggcctgcaa cctgatcctc ggagccccag attctcagaa actgaccaca      300

gttgacatcg tcaccctgag ggtgctgtgc cgtgaggggg tgcgatggag ggtgatggcc      360

atccaggact tcaagccctt tgagaacctt cgcctgatgg cccccatctc cctccaagtt      420

gtccacgtgg agacccacag atgcaacata agctgggaaa tctcccaagc ctcccactac      480

tttgaaagac acctggagtt cgaggcccgg acgctgtccc caggccacac ctgggaggag      540

gcccccctgc tgactctcaa gcagaagcag gaatggatct gcctggagac gctcacccca      600

gacacccagt atgagtttca ggtgcgggtc aagcctctgc aaggcgagtt cacgacctgg      660

agcccctgga gccagcccct ggccttcagg acaaagcctg cagcccttgg gaaggacacc      720

attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta      780

gtgtacttgc tgatcaactg caggaacacc gggccatggc tgaagaaggt cctgaagtgt      840

aacaccccag acccctcgaa gttcttttcc cagctgagct cagagcatgg aggagacgtc      900

cagaagtggc tctcttcgcc cttcccctca tcgtccttca gccctggcgg cctggcacct      960

gagatctcgc cactagaagt gctggagagg gacaaggtga cgcagctgct cctgcagcag     1020

gacaaggtgc ctgagcccgc atccttaagc agcaaccact cgctgaccag ctgcttcacc     1080

aaccagggtt acttcttctt ccacctcccg gatgccttgg agatagaggc ctgccaggtg     1140

tactttactt acgaccccta ctcagaggaa gaccctgatg agggtgtggc cggggcaccc     1200

acagggtctt ccccccaacc cctgcagcct ctgtcagggg aggacgacgc ctactgcacc     1260

ttcccctcca gggatgacct gctgctcttc tcccccagtc tcctcggtgg ccccagcccc     1320

ccaagcactg cccctggggg cagtggggcc ggtgaagaga ggatgccccc ttctttgcaa     1380

gaaagagtcc ccagagactg ggacccccag cccctggggc ctcccacccc aggagtccca     1440

gacctggtgg attttcagcc accccctgag ctggtgctgc gagaggctgg ggaggaggtc     1500

cctgacgctg gccccaggga gggagtcagt ttcccctggt ccaggcctcc tgggcagggg     1560

gagttcaggg cccttaatgc tcgcctgccc ctgaacactg atgcctactt gtccctccaa     1620

gaactccagg gtcaggaccc aactcacttg gtgtag                               1656


<210>  35
<211>  1800
<212>  DNA
<213>  Homo sapiens;

<400>  35
atggaggggc cactcactcc accaccgctg cagggaggcg gagccgccgc tgttccggag       60

cccggagccc ggcaacaccc gggacacgag acggcggcgc agcggtacag cgcccgactg      120

ctgcaggccg gctacgagcc cgagagccct agattggacc tcgctacaca cccgacgaca      180

ccccgttcag aactatcttc agtggtctta ctggcaggtg ttggtgtcca gatggatcgc      240

cttcgcaggg ctagcatggc ggactacctg atcagcggcg gcaccggcta cgtgcccgag      300

gatgggctca ccgcgcagca gctcttcgcc agcgccgacg gcctcaccta caacgacttc      360

ctgattctcc caggattcat agacttcata gctgatgagg tggacctgac ctcagccctg      420

acccggaaga tcacgctgaa gacgccactg atctcctccc ccatggacac tgtgacagag      480

gctgacatgg ccattgccat ggctctgatg ggaggtattg gtttcattca ccacaactgc      540

accccagagt tccaggccaa cgaggtgcgg aaggtcaaga agtttgaaca gggcttcatc      600

acggaccctg tggtgctgag cccctcgcac actgtgggcg atgtgctgga ggccaagatg      660

cggcatggct tctctggcat ccccatcact gagacgggca ccatgggcag caagctggtg      720

ggcatcgtca cctcccgaga catcgacttt cttgctgaga aggaccacac caccctcctc      780

agtgaggtga tgacgccaag gattgaactg gtggtggctc cagcaggtgt gacgttgaaa      840

gaggcaaatg agatcctgca gcgtagcaag aaagggaagc tgcctatcgt caatgattgc      900

gatgagctgg tggccatcat cgcccgcacc gacctgaaga agaaccgaga ctaccctctg      960

gcctccaagg attcccagaa gcagctgctc tgtggggcag ctgtgggcac ccgtgaggat     1020

gacaaatacc gtctggacct gctcacccag gcgggcgtcg acgtcatagt cttggactcg     1080

tcccaaggga attcggtgta tcagatcgcc atggtgcatt acatcaaaca gaagtacccc     1140

cacctccagg tgattggggg gaacgtggtg acagcagccc aggccaagaa cctgattgat     1200

gctggtgtgg acgggctgcg cgtgggcatg ggctgcggct ccatctgcat cacccaggaa     1260

gtgatggcct gtggtcggcc ccagggcact gctgtgtaca aggtggctga gtatgcccgg     1320

cgctttggtg tgcccatcat agccgatggc ggcatccaga ccgtgggaca cgtggtcaag     1380

gccctggccc ttggagcctc cacagtgatg atgggctccc tgctggccgc cactacggag     1440

gcccctggcg agtacttctt ctcagacggg gtgcggctca agaagtaccg gggcatgggc     1500

tcactggatg ccatggagaa gagcagcagc agccagaaac gatacttcag cgagggggat     1560

aaagtgaaga tcgcgcaggg tgtctcgggc tccatccagg acaaaggatc cattcagaag     1620

ttcgtgccct acctcatagc aggcatccaa cacggctgcc aggatatcgg ggcccgcagc     1680

ctgtctgtcc ttcggtccat gatgtactca ggagagctca agtttgagaa gcggaccatg     1740

tcggcccaga ttgagggtgg tgtccatggc ctgcactctt acgaaaagcg gctgtactga     1800


<210>  36
<211>  3567
<212>  DNA
<213>  Homo sapiens;

<400>  36
atggtcccct gctggaacca tggcaacatc acccgctcca aggcggagga gctgctttcc       60

aggacaggca aggacgggag cttcctcgtg cgtgccagcg agtccatctc ccgggcatac      120

gcgctctgcg tgctgtatcg gaattgcgtt tacacttaca gaattctgcc caatgaagat      180

gataaattca ctgttcaggc atccgaaggc gtctccatga ggttcttcac caagctggac      240

cagctcatcg agttttacaa gaaggaaaac atggggctgg tgacccatct gcaataccct      300

gtgccgctgg aggaagagga cacaggcgac gaccctgagg aggacacaga aagtgtcgtg      360

tctccacccg agctgccccc aagaaacatc ccgctgactg ccagctcctg tgaggccaag      420

gaggttcctt tttcaaacga gaatccccga gcgaccgaga ccagccggcc gagcctctcc      480

gagacattgt tccagcgact gcaaagcatg gacaccagtg ggcttccaga agagcatctt      540

aaggccatcc aagattattt aagcactcag ctcgcccagg actctgaatt tgtgaagaca      600

gggtccagca gtcttcctca cctgaagaaa ctgaccacac tgctctgcaa ggagctctat      660

ggagaagtca tccggaccct cccatccctg gagtctctgc agaggttatt tgaccagcag      720

ctctccccgg gcctccgtcc acgtcctcag gttcctggtg aggccaatcc catcaacatg      780

gtgtccaagc tcagccaact gacaagcctg ttgtcgtcca ttgaagacaa ggtcaaggcc      840

ttgctgcacg agggtcctga gtctccgcac cggccctccc ttatccctcc agtcaccttt      900

gaggtgaagg cagagtctct ggggattcct cagaaaatgc agctcaaagt cgacgttgag      960

tctgggaaac tgatcattaa gaagtccaag gatggttctg aggacaagtt ctacagccac     1020

aagaaaatcc tgcagctcat taagtcacag aaatttctga ataagttggt gatcttggtg     1080

gaaacagaga aggagaagat cctgcggaag gaatatgttt ttgctgactc caaaaagaga     1140

gaaggcttct gccagctcct gcagcagatg aagaacaagc actcagagca gccggagccc     1200

gacatgatca ccatcttcat cggcacctgg aacatgggta acgccccccc tcccaagaag     1260

atcacgtcct ggtttctctc caaggggcag ggaaagacgc gggacgactc tgcggactac     1320

atcccccatg acatttacgt gatcggcacc caagaggacc ccctgagtga gaaggagtgg     1380

ctggagatcc tcaaacactc cctgcaagaa atcaccagtg tgacttttaa aacagtcgcc     1440

atccacacgc tctggaacat ccgcatcgtg gtgctggcca agcctgagca cgagaaccgg     1500

atcagccaca tctgtactga caacgtgaag acaggcattg caaacacact ggggaacaag     1560

ggagccgtgg gggtgtcgtt catgttcaat ggaacctcct tagggttcgt caacagccac     1620

ttgacttcag gaagtgaaaa gaaactcagg cgaaaccaaa actatatgaa cattctccgg     1680

ttcctggccc tgggcgacaa gaagctgagt ccctttaaca tcactcaccg cttcacgcac     1740

ctcttctggt ttggggatct taactaccgt gtggatctgc ctacctggga ggcagaaacc     1800

atcatccaga aaatcaagca gcagcagtac gcagacctcc tgtcccacga ccagctgctc     1860

acagagagga gggagcagaa ggtcttccta cacttcgagg aggaagaaat cacgtttgcc     1920

ccaacctacc gttttgagag actgactcgg gacaaatacg cctacaccaa gcagaaagcg     1980

acagggatga agtacaactt gccttcctgg tgtgaccgag tcctctggaa gtcttatccc     2040

ctggtgcacg tggtgtgtca gtcttatggc agtaccagcg acatcatgac gagtgaccac     2100

agccctgtct ttgccacatt tgaggcagga gtcacttccc agtttgtctc caagaacggt     2160

cccgggactg ttgacagcca aggacagatt gagtttctca ggtgctatgc cacattgaag     2220

accaagtccc agaccaaatt ctacctggag ttccactcga gctgcttgga gagttttgtc     2280

aagagtcagg aaggagaaaa tgaagaagga agtgaggggg agctggtggt gaagtttggt     2340

gagactcttc caaagctgaa gcccattatc tctgaccctg agtacctgct agaccagcac     2400

atcctcatca gcatcaagtc ctctgacagc gacgaatcct atggcgaggg ctgcattgcc     2460

cttcggttag aggccacaga aacgcagctg cccatctaca cgcctctcac ccaccatggg     2520

gagttgacag gccacttcca gggggagatc aagctgcaga cctctcaggg caagacgagg     2580

gagaagctct atgactttgt gaagacggag cgtgatgaat ccagtgggcc aaagaccctg     2640

aagagcctca ccagccacga ccccatgaag cagtgggaag tcactagcag ggcccctccg     2700

tgcagtggct ccagcatcac tgaaatcatc aaccccaact acatgggagt ggggcccttt     2760

gggccaccaa tgcccctgca cgtgaagcag accttgtccc ctgaccagca gcccacagcc     2820

tggagctacg accagccgcc caaggactcc ccgctggggc cctgcagggg agaaagtcct     2880

ccgacacctc ccggccagcc gcccatatca cccaagaagt ttttaccctc aacagcaaac     2940

cggggtctcc ctcccaggac acaggagtca aggcccagtg acctggggaa gaacgcaggg     3000

gacacgctgc ctcaggagga cctgccgctg acgaagcccg agatgtttga gaaccccctg     3060

tatgggtccc tgagttcctt ccctaagcct gctcccagga aggaccagga atcccccaaa     3120

atgccgcgga aggaaccccc gccctgcccg gaacccggca tcttgtcgcc cagcatcgtg     3180

ctcaccaaag cccaggaggc tgatcgcggc gaggggcccg gcaagcaggt gcccgcgccc     3240

cggctgcgct ccttcacgtg ctcatcctct gccgagggca gggcggccgg cggggacaag     3300

agccaaggga agcccaagac cccggtcagc tcccaggccc cggtgccggc caagaggccc     3360

atcaagcctt ccagatcgga aatcaaccag cagaccccgc ccaccccgac gccgcggccg     3420

ccgctgccag tcaagagccc ggcggtgctg cacctccagc actccaaggg ccgcgactac     3480

cgcgacaaca ccgagctccc gcatcacggc aagcaccggc cggaggaggg gccaccaggg     3540

cctctaggca ggactgccat gcagtga                                         3567


<210>  37
<211>  3414
<212>  DNA
<213>  Homo sapiens;

<400>  37
atggccgggg ctcggagccg cgacccttgg ggggcctccg ggatttgcta cctttttggc       60

tccctgctcg tcgaactgct cttctcacgg gctgtcgcct tcaatctgga cgtgatgggt      120

gccttgcgca aggagggcga gccaggcagc ctcttcggct tctctgtggc cctgcaccgg      180

cagttgcagc cccgacccca gagctggctg ctggtgggtg ctccccaggc cctggctctt      240

cctgggcagc aggcgaatcg cactggaggc ctcttcgctt gcccgttgag cctggaggag      300

actgactgct acagagtgga catcgaccag ggagctgata tgcaaaagga aagcaaggag      360

aaccagtggt tgggagtcag tgttcggagc caggggcctg ggggcaagat tgttacctgt      420

gcacaccgat atgaggcaag gcagcgagtg gaccagatcc tggagacgcg ggatatgatt      480

ggtcgctgct ttgtgctcag ccaggacctg gccatccggg atgagttgga tggtggggaa      540

tggaagttct gtgagggacg cccccaaggc catgaacaat ttgggttctg ccagcagggc      600

acagctgccg ccttctcccc tgatagccac tacctcctct ttggggcccc aggaacctat      660

aattggaagg ggttgctttt tgtgaccaac attgatagct cagaccccga ccagctggtg      720

tataaaactt tggaccctgc tgaccggctc ccaggaccag ccggagactt ggccctcaat      780

agctacttag gcttctctat tgactcgggg aaaggtctgg tgcgtgcaga agagctgagc      840

tttgtggctg gagccccccg cgccaaccac aagggtgctg tggtcatcct gcgcaaggac      900

agcgccagtc gcctggtgcc cgaggttatg ctgtctgggg agcgcctgac ctccggcttt      960

ggctactcac tggctgtggc tgacctcaac agtgatggct ggccagacct gatagtgggt     1020

gccccctact tctttgagcg ccaagaagag ctggggggtg ctgtgtatgt gtacttgaac     1080

caggggggtc actgggctgg gatctcccct ctccggctct gcggctcccc tgactccatg     1140

ttcgggatca gcctggctgt cctgggggac ctcaaccaag atggctttcc agatattgca     1200

gtgggtgccc cctttgatgg tgatgggaaa gtcttcatct accatgggag cagcctgggg     1260

gttgtcgcca aaccttcaca ggtgctggag ggcgaggctg tgggcatcaa gagcttcggc     1320

tactccctgt caggcagctt ggatatggat gggaaccaat accctgacct gctggtgggc     1380

tccctggctg acaccgcagt gctcttcagg gccagaccca tcctccatgt ctcccatgag     1440

gtctctattg ctccacgaag catcgacctg gagcagccca actgtgctgg cggccactcg     1500

gtctgtgtgg acctaagggt ctgtttcagc tacattgcag tccccagcag ctatagccct     1560

actgtggccc tggactatgt gttagatgcg gacacagacc ggaggctccg gggccaggtt     1620

ccccgtgtga cgttcctgag ccgtaacctg gaagaaccca agcaccaggc ctcgggcacc     1680

gtgtggctga agcaccagca tgaccgagtc tgtggagacg ccatgttcca gctccaggaa     1740

aatgtcaaag acaagcttcg ggccattgta gtgaccttgt cctacagtct ccagacccct     1800

cggctccggc gacaggctcc tggccagggg ctgcctccag tggcccccat cctcaatgcc     1860

caccagccca gcacccagcg ggcagagatc cacttcctga agcaaggctg tggtgaagac     1920

aagatctgcc agagcaatct gcagctggtc cgcgcccgct tctgtacccg ggtcagcgac     1980

acggaattcc aacctctgcc catggatgtg gatggaacaa cagccctgtt tgcactgagt     2040

gggcagccag tcattggcct ggagctgatg gtcaccaacc tgccatcgga cccagcccag     2100

ccccaggctg atggggatga tgcccatgaa gcccagctcc tggtcatgct tcctgactca     2160

ctgcactact caggggtccg ggccctggac cctgcggaga agccactctg cctgtccaat     2220

gagaatgcct cccatgttga gtgtgagctg gggaacccca tgaagagagg tgcccaggtc     2280

accttctacc tcatccttag cacctccggg atcagcattg agaccacgga actggaggta     2340

gagctgctgt tggccacgat cagtgagcag gagctgcatc cagtctctgc acgagcccgt     2400

gtcttcattg agctgccact gtccattgca ggaatggcca ttccccagca actcttcttc     2460

tctggtgtgg tgaggggcga gagagccatg cagtctgagc gggatgtggg cagcaaggtc     2520

aagtatgagg tcacggtttc caaccaaggc cagtcgctca gaaccctggg ctctgccttc     2580

ctcaacatca tgtggcctca tgagattgcc aatgggaagt ggttgctgta cccaatgcag     2640

gttgagctgg agggcgggca ggggcctggg cagaaagggc tttgctctcc caggcccaac     2700

atcctccacc tggatgtgga cagtagggat aggaggcggc gggagctgga gccacctgag     2760

cagcaggagc ctggtgagcg gcaggagccc agcatgtcct ggtggccagt gtcctctgct     2820

gagaagaaga aaaacatcac cctggactgc gcccggggca cggccaactg tgtggtgttc     2880

agctgcccac tctacagctt tgaccgcgcg gctgtgctgc atgtctgggg ccgtctctgg     2940

aacagcacct ttctggagga gtactcagct gtgaagtccc tggaagtgat tgtccgggcc     3000

aacatcacag tgaagtcctc cataaagaac ttgatgctcc gagatgcctc cacagtgatc     3060

ccagtgatgg tatacttgga ccccatggct gtggtggcag aaggagtgcc ctggtgggtc     3120

atcctcctgg ctgtactggc tgggctgctg gtgctagcac tgctggtgct gctcctgtgg     3180

aagatgggat tcttcaaacg ggcgaagcac cccgaggcca ccgtgcccca gtaccatgcg     3240

gtgaagattc ctcgggaaga ccgacagcag ttcaaggagg agaagacggg caccatcctg     3300

aggaacaact ggggcagccc ccggcgggag ggcccggatg cacaccccat cctggctgct     3360

gacgggcatc ccgagctggg ccccgatggg catccagggc caggcaccgc ctag           3414


<210>  38
<211>  3741
<212>  DNA
<213>  Homo sapiens;

<400>  38
atgagcaagg aaagacccaa gaggaatatc attcagaaga aatacgatga cagtgatggg       60

attccgtggt cagaagaacg ggtggtacgt aaagtccttt atttgtctct gaaggagttc      120

aagaattccc agaagaggca gcatgcggaa ggcattgctg ggagcctgaa aactgtgaat      180

gggctccttg gtaatgacca gtctaaggga ttaggaccag catcagaaca gtcagagaat      240

gaaaaggacg atgcatccca agtgtcctcc actagcaacg atgttagttc ttcagatttt      300

gaagaagggc cgtcgaggaa aaggcccagg ctgcaagcac aaaggaagtt tgctcagtct      360

cagccgaata gtcccagcac aactccagta aagatagtgg agccattgct accccctcca      420

gctactcaga tatcagacct ctctaaaagg aagcctaaga cagaagattt tcttaccttt      480

ctctgccttc gaggttctcc tgcgctgccc aacagcatgg tgtattttgg aagctctcag      540

gatgaggagg aagtcgagga ggaagatgat gagacagaag acgtcaaaac agccaccaac      600

aatgcttcat cttcatgcca gtcgaccccc aggaaaggaa aaacccacaa acatgttcac      660

aacgggcatg ttttcaatgg ttccagcagg tcaacacggg agaaggaacc tgttcaaaaa      720

cacaaaagca aagaggccac tcccgcaaag gagaagcaca gcgatcaccg ggctgacagc      780

cgccgggagc aggcttcagc taaccacccc gcagcggccc cctccacggg ttcctcggcc      840

aaggggcttg ctgccaccca tcaccacccc cctctgcatc ggtcggctca ggacttacgg      900

aaacaggttt ctaaggtaaa cggagtcact cgaatgtcat ctctgggtgc aggtgtaacc      960

agtgccaaaa agatgcgcga ggtcagacct tcaccatcca aaactgtgaa gtacactgcc     1020

acggtgacga agggggctgt cacatacacc aaagccaaga gagaactggt caaggacacc     1080

aaacccaatc accacaagcc cagttccgct gtcaaccaca caatctcagg gaaaactgaa     1140

agtagcaatg caaaaacccg caaacaggtg ctatccctcg ggggggcgtc caagtccact     1200

gggcccgccg tcaatggcct caaggtcagt ggcaggttga acccaaagtc atgcactaag     1260

gaggtggggg ggcggcagct gcgggagggc ctgcagctgc gggaggggct gcggaactcc     1320

aagaggagac tggaagaggc acaccaggcg gagaagccgc agtcgccccc caagaagatg     1380

aaaggggcgg ctggccccgc cgaaggccct ggcaagaagg ccccggccga gagaggtctg     1440

ctgaacggac acgtgaagaa ggaagtgccg gagcgcagtc tggagaggaa tcggccgaag     1500

cgggccacgg ccgggaagag cacgccaggc agacaagcac atggcaaggc ggacagcgcc     1560

tcctgtgaaa atcgttctac ctcgcaaccg gagtccgtgc acaagccgca ggactcgggc     1620

aaggccgaga agggcggcgg caaggccggg tgggcggcca tggacgagat ccccgtcctc     1680

aggccctccg ccaaggagtt ccacgatccg ctcatctaca tcgagtcggt ccgcgctcag     1740

gtggagaagt tcgggatgtg cagggtgatc ccccctccgg actggcggcc cgagtgcaag     1800

ctcaacgatg agatgcggtt tgtcacgcag attcagcaca tccacaagct gggccggcgc     1860

tggggcccca acgtgcagcg gctggcctgc atcaagaagc acctcaaatc tcagggcatc     1920

accatggacg agctcccgct catagggggc tgtgagctcg acctggcctg ctttttccgg     1980

ctgattaatg agatgggcgg catgcagcaa gtgactgacc tcaaaaaatg gaacaaacta     2040

gcagacatgc tgcgcatccc cagaactgcc caggaccggc tggccaagct gcaggaggcc     2100

tactgccagt acctactctc ctacgactcc ctgtccccag aggagcaccg gcggctggag     2160

aaggaggtgc tgatggagaa ggagatcctg gagaagcgca aggggccgct ggaaggccac     2220

acagagaacg accaccacaa gttccaccct ctgccccgct tcgagcccaa gaatgggctc     2280

atccacggcg tggcccccag gaacggcttc cgcagcaagc tcaaggaggt gggccaggcc     2340

cagttgaaga ctggccggcg gcgactcttc gctcaggaaa aagaagtggt caaggaagag     2400

gaggaggaca aaggcgtcct caatgacttc cacaagtgca tctataaggg aaggtctgtt     2460

tctctaacaa ctttttatcg aacagcgagg aatatcatga gcatgtgttt cagcaaggag     2520

cctgccccag ccgaaatcga gcaagagtac tggaggctag tggaagagaa ggactgccac     2580

gtggcagtgc actgcggcaa ggtggacacc aacactcacg gcagtggatt cccagtagga     2640

aaatcagaac ccttttcgag gcatggatgg aacctcaccg tcctccccaa taacacaggg     2700

tccatcctgc gtcacctcgg tgctgtgcct ggagtgacta ttccctggct aaatattggc     2760

atggtctttt ctacctcatg ctggtctcga gaccaaaatc accttccata cattgactac     2820

ttacacactg gtgctgactg catttggtat tgcattcctg ctgaggagga gaacaagctg     2880

gaagatgtgg tccacaccct gctgcaagcc aatggcaccc cagggctgca gatgctggaa     2940

agcaacgtca tgatctcccc ggaggtgctg tgcaaagagg ggatcaaggt gcacaggacc     3000

gtgcagcaga gtggccagtt tgtcgtctgc ttcccgggat cctttgtgtc caaagtgtgc     3060

tgtgggtaca gcgtgtctga aaccgtgcac tttgctacca cccagtggac aagtatgggc     3120

tttgagaccg ccaaggaaat gaagcgtcgc catatagcta agccattctc catggagaag     3180

ttactctacc agattgcaca agcagaagca aaaaaagaaa acggtcccac tctcagtacc     3240

atctcagccc tcctggatga gctcagggat acagagctgc ggcagcgcag gcagctgttc     3300

gaggctggcc tccactcctc cgcacgctat ggcagccacg atggcagcag cacggtggcg     3360

gacgggaaga aaaagcctcg aaagtggctg cagttggaga cgtcagagag gaggtgtcag     3420

atctgccagc acctgtgcta cctgtccatg gtggtacaag agaacgaaaa cgtcgtgttc     3480

tgtctggagt gtgctctgcg ccacgtggag aaacagaagt cctgccgagg gctgaagttg     3540

atgtaccgct acgatgagga acagattatc agtctggtca atcagatctg cggcaaagtg     3600

tctggtaaaa acggcagcat tgagaactgt ctcagtaaac ccacaccaaa aagaggtccc     3660

cgcaagagag cgacagtgga cgtgcccccc tcccgtctgt cagcctccag ttcatccaaa     3720

agtgcttcga gctcatcatg a                                               3741


<210>  39
<211>  336
<212>  DNA
<213>  Homo sapiens;

<400>  39
atggtgcgga ctaaagcaga cagtgttcca ggcacttaca gaaaagtggt ggctgctcga       60

gcccccagaa aggtgcttgg ttcttccacc tctgccacta attcgacatc agtttcatcg      120

aggaaagctg aaaataaata tgcaggaggg aaccccgttt gcgtgcgccc aactcccaag      180

tggcaaaaag gaattggaga attctttagg ttgtccccta aagattctga aaaagagaat      240

cagattcctg aagaggcagg aagcagtggc ttaggaaaag caaagagaaa agcatgtcct      300

ttgcaacctg atcacacaaa tgatgaaaaa gaatag                                336


<210>  40
<211>  3213
<212>  DNA
<213>  Homo sapiens;

<400>  40
atgtattgct gcagtgccca ggacagtaaa atggactaca agcggcgctt cctgcttggc       60

gggtccaagc agaaggtgca gcagcaccag caatacccga tgcctgagct gggccgagca      120

ctgagtgctc ccctggcatc cacggccacc actgcccccc tgggcagtct gaccgctgca      180

ggcagctgcc accatgccat gccccacact actcctatcg ccgacatcca gcagggcatc      240

tccaagtatc tggatgccct gaacgtcttc tgccgtgcca gtactttcct cacagatctc      300

ttcagcactg tgttcaggaa ctctcactac tcaaaggcag ccacacagct caaagatgtg      360

caggagcatg tcatggaagc agccagtcgg ctgacctcgg ccataaagcc tgagatcgcc      420

aagatgctaa tggaacttag tgctggggct gcaaatttta cggatcagaa ggaattcagt      480

ctccaggaca ttgaggtgtt ggggcgatgt ttcctgactg tggtgcaagt ccatttccag      540

tttttgactc atgcgttaca gaaggtccag ccggtggctc actcttgctt tgctgaggtc      600

atcgtgccag aaaaaaagaa cagcggcagt ggcggcggct tatctggcat gggccacaca      660

cctgaagtag aggaagctgt gcggtcctgg cggggggctg ctgaggcgac atctagacta      720

agagaaagag gctgtgatgg ttgcctggca ggaattgaag ttcaacaact cttttgttct      780

caaagtgcag caattcctga gcaccagcta aaagaactga acataaaaat cgacagtgct      840

ttgcaagcat ataagatagc tctggaaagc ttaggacact gtgaatatgc aatgaaagcc      900

ggcttccacc tgaatccaaa ggcgattgaa gcaagtttgc agggctgctg cagcgaggcg      960

gaagcccagc agacggggcg gaggcagaca cccccgcagc ccatgcagtg tgagctcccc     1020

accgtccctg tgcagatagg atcgcacttc ctgaagggcg tctcctttaa tgagtcggcc     1080

gccgacaatc tgaaacttaa gacgcataca atgttacagc tgatgaagga ggcaggctgc     1140

tataatggaa tcacatccag ggatgatttt cctgtgactg aagtgctgaa ccaggtttgc     1200

ccttccacat ggcgaggtgc ctgcaagacg gcggtgcagc tgctgtttgg ccaggctgga     1260

ctggtggtgg ttgacacagc acagattgag aataaagaag cctatgcccc ccagatcagt     1320

ttagaaggct ctagaatcgt ggttcaagtc ccatccacat ggtgcctgaa agaagaccct     1380

gctaccatgt ccctgctgca gagaagcctt gatcctgaga agaccctggg tctagtggac     1440

gtgctctaca cagctgtgct ggacctaaac cgctggaggg ctggaaggga gcaagcttta     1500

ccctgcatac agatccagct gcaaagggag atctgtgatt ttggcaacca ggctgacctg     1560

ccttctggaa atggaaacaa atcttcaggt ggcctgcaga agacattctc caaactgaca     1620

tcccggttca ccaagaaagc ttcatgtacc agctccagca gcagcacaaa ttattccatc     1680

caaaataccc cttccaaaaa catcttcata gctggatgtt ccgaagagaa ggccaaaatg     1740

cctggcaata ttgatacaag gttacaaagc attttgaaca ttggtaattt ccccaggact     1800

acagaccctt cacagtcagc tcagaattcc agtaatacag tggccaatgg ctttctcatg     1860

gagaggcgtg agaacttcct gcatggagat gacggcaagg atgagaaggg tatgaactta     1920

ccaactgatc aggaaatgca agaggtgata gattttctct cgggctttaa catgggccag     1980

tcacatcagg gctctccgtt ggtgacaagg cataattctg ctgccacagc catggtgact     2040

gagcagaagg caggagccat gcaaccacag cagccgtcac tgcctgtgcc ccctccacca     2100

cgggcacccc aggctggggc acacacacct ctgacacccc agccgggact ggcacctcag     2160

cagcagtccc caaagcagca acaacctcaa gtccaatact accaacacct actccagccc     2220

attggaccgc agcagccccc gccccagcct cgggcacctg ggaaatgggt acatggctca     2280

tcccagcagc cagcgcaggc tgttggagca ggtctgtctc ctcttggtca gtggcctggc     2340

atatctgatc tcagttctga cttgtacagc ttgggtctgg tgagcagcta tatggataat     2400

gtgatgtcag aggttctggg acagaagccg cagggaccta gaaataacac ctggcccaac     2460

cgtgaccaaa gtgatggagt ctttggaatg ctgggagaga ttctgccttt tgatcctgca     2520

gtgggctcag acccagagtt tgcacgctat gtggcaggag tgagccaggc gatgcagcag     2580

aagcggcagg cccagcacgg tcgccggcca ggcaaccccc ggggcaactg gccgcctatg     2640

gatgacgcgc atcggacctg gcccttcccc gagttcttca cagaagggga tggcctgcac     2700

ggtggctggt cgggtgctca gggagactct gccagctcga gtgatgagac atcctcagcc     2760

aacggggaca gcttgttctc catgttttca gggcctgacc tcgttgctgc tgtcaagcag     2820

agaaggaaac acagcagtgg agagcaagac accagcacgc tgccctcacc acctctcctc     2880

accacggtgg aggatgtgaa ccaggataac aaaaccaaaa cgtggccacc caaagcaccc     2940

tggcagcacc cttccccgct tcccagcacg ctgcccagcc ccagcgcacc actctatgca     3000

gtcaccagcc ctggcagcca gtggaacgac accatgcaga tgctgcagtc cccagtgtgg     3060

gccgcaacca acgactgcag tgccgctgcc ttctcctatg tgcagacccc accccagccc     3120

ccacccccac cagcacacaa ggcagcaccc aagggcttca aggccttccc tgggaagggt     3180

gagcgcaggc cagcctatct gccccagtac tga                                  3213


<210>  41
<211>  1845
<212>  DNA
<213>  Homo sapiens;

<400>  41
atgtccgcgg ggagcgcgac acatcctgga gctggcgggc gccgcagcaa atgggaccaa       60

ccagctccag ccccacttct cttcctcccg ccagcggccc caggtgggga ggtcaccagc      120

agtgggggaa gtcctggggg caccacagct gctccttcag gagccttgga tgctgctgct      180

gctgtggctg ccaagattaa tgccatgctc atggcaaaag ggaagctgaa accaactcag      240

aatgcttctg agaagcttca ggctcctggc aaaggcctaa ctagcaataa aagcaaggat      300

gacctggtgg tagctgaagt agaaattaat gatgtgcctc tcacatgtag gaacttgctg      360

actcgaggac agactcaaga cgagatcagc cgacttagtg gggctgcagt atcaactcga      420

gggaggttca tgacaactga ggaaaaagcc aaagtgggac caggggatcg tccattatat      480

cttcatgttc agggccagac acgggaatta gtggacagag ctgtaaaccg gatcaaagaa      540

attatcacca atggagtggt aaaagctgcc acaggaacaa gtccaacttt taatggtgca      600

acagtaactg tctatcacca gccagcaccc atcgctcagt tgtctccagc tgttagccag      660

aagcctccct tccagtcagg gatgcattat gttcaagata aattatttgt gggtctagaa      720

catgctgtac ccacttttaa tgtcaaggag aaggtggaag gtccaggctg ctcctatttg      780

cagcacattc agattgaaac aggtgccaaa gtcttcctgc ggggcaaagg ttcaggctgc      840

attgagccag catctggccg agaagctttt gaacctatgt atatttacat cagtcacccc      900

aaaccagaag gcctggctgc tgccaagaag ctttgtgaga atcttttgca aacagttcat      960

gctgaatact ctagatttgt gaatcagatt aatactgctg tacctttacc aggctataca     1020

caaccctctg ctataagtag tgtccctcct caaccaccat attatccatc caatggctat     1080

cagtctggtt accctgttgt tccccctcct cagcagccag ttcaacctcc ctacggagta     1140

ccaagcatag tgccaccagc tgtttcatta gcacctggag tcttgccggc attacctact     1200

ggagtcccac ctgtgccaac acaatacccg ataacacaag tgcagcctcc agctagcact     1260

ggacagagtc cgatgggtgg tccttttatt cctgctgctc ctgtcaaaac tgccttgcct     1320

gctggccccc agccccagcc ccagccccag cccccactcc caagtcagcc ccaggcacag     1380

aagagacgat tcacagagga gctaccagat gaacgggaat ctggactgct tggataccag     1440

catggaccca ttcatatgac taatttaggt acaggcttct ccagtcagaa tgagattgaa     1500

ggtgcaggat cgaagccagc aagttcctca ggcaaagaga gagagaggga caggcagttg     1560

atgcctccac cagcctttcc agtgactgga ataaaaacag agtccgatga aaggaatggg     1620

tctgggacct taacagggag ccatgattat ccagccaaga agatgaaaac tacagagaag     1680

ggatttggct tggtggctta tgctgcagat tcatctgatg aagaggagga acatggaggt     1740

cataaaaatg caagtagttt tccacagggc tggagtttgg gataccaata tccttcatca     1800

caaccacgag ctaaacaaca gatgccattc tggatggctc cctag                     1845


<210>  42
<211>  540
<212>  DNA
<213>  Homo sapiens;

<400>  42
atggcagtgt ttaagaccac tctgtggagg ttaatttctg ggaccttagg gataatatgc       60

ctttcgttga tgtctacgtt gggaattttg ttgaaaaatt cttttactaa actgagtatt      120

gagccagcat ttactccagg acccaacata gaactccaga aagactctga ctgctgttct      180

tgccaagaaa aatgggttgg gtaccggtgc aactgttact tcatttccag tgaacagaaa      240

acttggaacg aaagtcggca tctctgtgct tctcagaaat ccagcctgct tcagcttcaa      300

aacacagatg aactggattt tatgagctcc agtcaacaat tttactggat tggactctct      360

tacagtgagg agcacaccgc ctggttgtgg gagaatggct ctgcactctc ccagtatcta      420

tttccatcat ttgaaacttt taatacaaag aactgcatag cgtataatcc aaatggaaat      480

gctttagatg aatcctgtga agataaaaat cgttatatct gtaagcaaca gctcatttaa      540


<210>  43
<211>  696
<212>  DNA
<213>  Homo sapiens;

<400>  43
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggtttctc agggagtatt gctaaaatgc caaaaaggaa gttgttcaaa tgccactcag      240

tatgaggaca ctggagatct aaaagtgaat aatggcacaa gaagaaatat aagtaataag      300

gacctttgtg cttcgagatc tgcagaccag acagtactat gccaatcaga atggctcaaa      360

taccaaggga agtgttattg gttctctaat gagatgaaaa gctggagtga cagttatgtg      420

tattgtttgg aaagaaaatc tcatctacta atcatacatg accaacttga aatggctttt      480

atacagaaaa acctaagaca attaaactac gtatggattg ggcttaactt tacctccttg      540

aaaatgacat ggacttgggt ggatggttct ccaatagatt caaagatatt cttcataaag      600

ggaccagcta aagaaaacag ctgtgctgcc attaaggaaa gcaaaatttt ctctgaaacc      660

tgcagcagtg ttttcaaatg gatttgtcag tattag                                696


<210>  44
<211>  1578
<212>  DNA
<213>  Homo sapiens;

<400>  44
atgtgggagg ctcagttcct gggcttgctg tttctgcagc cgctttgggt ggctccagtg       60

aagcctctcc agccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc      120

cagctcccct gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg      180

gtcacttggc agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg      240

gcccccggcc ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg      300

gtgctgagcg tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc      360

cagctggatg agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg      420

cgcgcggacg ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc      480

cgcctccgtc tgcgcctggg ccaggcctcg atgactgcca gccccccagg atctctcaga      540

gcctccgact gggtcatttt gaactgctcc ttcagccgcc ctgaccgccc agcctctgtg      600

cattggttcc ggaaccgggg ccagggccga gtccctgtcc gggagtcccc ccatcaccac      660

ttagcggaaa gcttcctctt cctgccccaa gtcagcccca tggactctgg gccctggggc      720

tgcatcctca cctacagaga tggcttcaac gtctccatca tgtataacct cactgttctg      780

ggtctggagc ccccaactcc cttgacagtg tacgctggag caggttccag ggtggggctg      840

ccctgccgcc tgcctgctgg tgtggggacc cggtctttcc tcactgccaa gtggactcct      900

cctgggggag gccctgacct cctggtgact ggagacaatg gcgactttac ccttcgacta      960

gaggatgtga gccaggccca ggctgggacc tacacctgcc atatccatct gcaggaacag     1020

cagctcaatg ccactgtcac attggcaatc atcacagtga ctcccaaatc ctttgggtca     1080

cctggatccc tggggaagct gctttgtgag gtgactccag tatctggaca agaacgcttt     1140

gtgtggagct ctctggacac cccatcccag aggagtttct caggaccttg gctggaggca     1200

caggaggccc agctcctttc ccagccttgg caatgccagc tgtaccaggg ggagaggctt     1260

cttggagcag cagtgtactt cacagagctg tctagcccag gtgcccaacg ctctgggaga     1320

gccccaggtg ccctcccagc aggccacctc ctgctgtttc tcatccttgg tgtcctttct     1380

ctgctccttt tggtgactgg agcctttggc tttcaccttt ggagaagaca gtggcgacca     1440

agacgatttt ctgccttaga gcaagggatt caccctccgc aggctcagag caagatagag     1500

gagctggagc aagaaccgga gccggagccg gagccggaac cggagcccga gcccgagccc     1560

gagccggagc agctctga                                                   1578


<210>  45
<211>  396
<212>  DNA
<213>  Homo sapiens;

<400>  45
atggcaggca tcaaagcttt gattagtttg tcctttggag gagcaatcgg actgatgttt       60

ttgatgcttg gatgtgccct tccaatatac aacaaatact ggcccctctt tgttctattt      120

ttttacatcc tttcacctat tccatactgc atagcaagaa gattagtgga tgatacagat      180

gctatgagta acgcttgtaa ggaacttgcc atctttctta caacgggcat tgtcgtgtca      240

gcttttggac tccctattgt atttgccaga gcacatctga ttgagtgggg agcttgtgca      300

cttgttctca caggaaacac agtcatcttt gcaactatac taggcttttt cttggtcttt      360

ggaagcaatg acgacttcag ctggcagcag tggtga                                396


<210>  46
<211>  2691
<212>  DNA
<213>  Homo sapiens;

<400>  46
atgaattatg tgggacagct ggctgggcag gtgattgtca ctgtgaagga actctacaag       60

ggcattaacc aggccaccct ctctgggtgc attgatgtca tcgtggtaca gcagcaggat      120

ggcagctatc agtgttcacc ttttcacgtt cggtttggaa agctgggagt cctgagatcc      180

aaagagaaag tgattgatat agaaatcaac ggcagtgcag tggatcttca catgaagttg      240

ggtgataacg gagaagcttt ctttgttgag gagactgaag aagaatatga aaagcttcct      300

gcttaccttg ccacctcacc aattcctact gaagatcagt tctttaaaga tattgacacc      360

cctttggtga aatcgggtgg agatgaaaca ccatctcaga gttcagacat ctcacacgtc      420

ttggaaacag agacaatttt tactccaagt tctgtgaaaa agaaaaaacg aaggagaaag      480

aaatacaaac aggacagtaa gaaggaagag caggccgcat ctgctgctgc agaagacaca      540

tgtgatgtag gcgtgagctc cgatgatgac aagggggccc aggcagcacg aggatcttca      600

aatgcttcct tgaaagaaga agaatgtaaa gagcctttgc tcttccattc tggggatcat      660

taccccttat ctgatggaga ttggtcccct ttagagacca cctatcccca gacagcgtgt      720

cctaagagtg attcagagct ggaggtgaaa cctgcggaga gcctgctcag atcagagtct      780

cacatggagt ggacgtgggg cggattccca gagtccacca aggtcagcaa aagagaacga      840

tctgaccatc atcctaggac agctacaatt acaccatcag aaaatactca ttttcgggta      900

attcccagtg aggacaacct catcagtgaa gttgagaagg atgcttccat ggaagacact      960

gtctgtacca tagtgaagcc caaacccaga gccctgggta cacagatgag cgacccaaca     1020

tctgtggcag agcttctcga acctcctctt gagagtactc agatttcatc tatgttagat     1080

gctgaccacc ttcccaacgc agccttagcg gaggcgccct cagaatccaa accggcagct     1140

aaagtagact cgccgtcaaa gaagaaaggt gttcacaaaa gaagccaaca ccagggacct     1200

gatgatattt accttgatga cttaaagggt ctagaacctg aagttgcagc tctttatttc     1260

cctaaaagtg aatcggagcc cggttccagg cagtggcccg agtctgacac actctctggc     1320

tcccagtccc cacagtccgt gggaagcgca gctgcagata gcggcaccga gtgcctctca     1380

gattctgcca tggacttgcc tgacgttacc ctctcccttt gcgggggcct cagtgaaaat     1440

ggagaaattt caaaagaaaa attcatggag catatcatta cttatcacga atttgcagaa     1500

aaccctggac ttatagacaa tcctaacctt gtaataagga tatataatcg ttactataac     1560

tgggctttgg cagctcccat gatccttagc ttgcaagtat tccagaagag cttgcctaag     1620

gccacagttg agtcctgggt gaaagacaag atgccaaaga aatctggtcg ctggtggttt     1680

tggcgaaaga gagaaagcat gaccaaacag ctgccagaat ccaaggaggg aaaatctgag     1740

gcaccgccag ccagtgacct gccatccagc tccaaggagc cggccggtgc caggccggcc     1800

gagaatgact cctcgagtga cgagggatca caggagctcg aagaatccat cacagtggac     1860

cccatcccca cagagcccct gagccacggc agcacaactt catataagaa gtctctccgc     1920

ctctcctcag accagatcgc aaaactgaag ctccacgatg gcccaaatga tgttgtgttt     1980

agtattacaa cccagtatca aggcacctgt cgctgtgcag ggaccattta cctgtggaac     2040

tggaatgaca agatcatcat ttctgatatt gatgggacaa taaccaagtc ggatgctttg     2100

ggacagattc tcccacagct gggcaaagac tggacccacc agggtatagc aaagctctac     2160

cattccatca atgagaatgg ctacaagttt ctgtactgct cggctcgtgc catcggcatg     2220

gccgacatga cccgtggcta cctgcactgg gtcaatgaca agggcacaat cttgccccgg     2280

ggccccctga tgctgtcccc cagcagcttg ttctccgcct tccacagaga agtgatagaa     2340

aagaaaccag agaagttcaa aattgagtgt ctaaatgata tcaagaatct gtttgccccg     2400

tctaagcagc ccttctatgc tgcctttgga aaccgtccaa atgatgtcta tgcctacaca     2460

caagttggag ttccagactg tagaatattc accgtgaacc ccaagggtga attaatacaa     2520

gaaagaacca aaggaaacaa gtcatcgtat cacaggctga gtgagctcgt ggagcatgtg     2580

ttcccccttc tcagtaagga gcagaattcc gcttttccct gcccggagtt cagctccttc     2640

tgctactggc gagacccgat ccctgaagtg gacctggatg acctgtcttg a              2691


<210>  47
<211>  1035
<212>  DNA
<213>  Homo sapiens;

<400>  47
atggctgctg ccacggagct taatcgcccg agcagcggtg acaggaacct ggagcgaaga       60

tgcagaccca acctctcccg agaggtgctc tacgaaatct ttcgctccct acacaccctg      120

gttggacagc ttgacctcag agatgatgtg gtgaaaatta caatcgattg gaacaagctc      180

cagagcctct cggcattcca gcctgcattg ctctttagtg cacttgaaca acacatttta      240

tatttacagc cttttttagc aaaacttcag tctccgatta aagaggagaa tacaactgct      300

gttgaagaga taggaagaac agaaatgggg aacaaaaatg aagtaaatga caaattttcc      360

attggcgacc tacaagagga agaaaagcac aaagaaagtg atttaagaga tgtgaaaaag      420

acacagatcc attttgatcc agaagtagtt cagataaagg ctggaaaagc agaaattgac      480

agacgaatat ctgcatttat tgaaagaaag caagctgaaa tcaatgaaaa caacgtcagg      540

gaattttgca atgttattga ttgtaatcaa gaaaatagtt gtgcaagaac tgatgcgatt      600

tttacccctt accccggatt taaaagtcac gtaaaagttt ctagagttgt gaatacatac      660

ggaccacaga ctagacctga aggaattcca gggtcaggtc ataaacctaa cagcatgctt      720

cgagactgtg gtaatcaggc tgtagaagaa cgactacaaa atattgaggc ccacttgcgg      780

ttacagacag gtggtccagt gccaagagac atttatcaga gaattaaaaa acttgaggat      840

aaaatccttg aattggaagg catctctcct gaatattttc agtctgtaag cttttctgga      900

aaaagaagaa aagttcaacc acctcaacag aactattcac tggctgaact tgatgagaaa      960

attagtgccc tcaaacaagc cctcctcaga aaatcaagag aagcagaatc catggcaacc     1020

caccaccttc catga                                                      1035


<210>  48
<211>  3000
<212>  DNA
<213>  Homo sapiens;

<400>  48
atggagcccc gggctgccgc ggcgggcgag ccagagccgc cggcggcgtc ctcctccttc       60

caggcccggc tctggaagaa cctgcagctg ggggtgggca ggagcaaggg cggcgggggc      120

gggcgcgctg ggggtccaga gcgccgcact gcggacaccc cgtcgccctc cccgccaccc      180

ccggtgggca cagggaatgc accggccagg gggagtggtg caggcagcag gtggagcggc      240

ttcaagaagc ggaagcaagt gctggaccga gtcttctcct cctcgcagcc caacctgtgc      300

tgctcgtcgc cggagcccct ggagcccggc ggcgccggca gagccgagca ggggtccacg      360

ctacgccgcc ggatccgcga gcatttgctc cccgccgtaa aggggcccgc ggcggcctcg      420

ggagcagcgg gagggacgcc tcctggcgga cgctcccccg actcagctcc ttcctcttcc      480

tccgcctcat cctccctgtc ctcctcgccc cagcctcccc cgagggggga ccgcgcccga      540

gatgagggtg cacggcgtca gggccccggg gcgcacttgt gccaccagaa gagctcctct      600

ctgccgggca ccgcctgcct ggagcagctg ctggagccgc cgcctcctcc cgcagagccg      660

gcgcggagtc ccgcggagtc tcgggccccg gagacgggcg aggagcacgg cagcagccag      720

aaaataataa acactgctgg aaccagtaat gcagaagtcc ccttggctga tcccggaatg      780

taccagctgg acattacatt aagaaggggt caaagtttag ctgctcgaga tcgaggaggg      840

acgagtgatc catatgtgaa gtttaaaatc ggaggaaaag aagtttttag aagtaagata      900

atacacaaga acctcaaccc tgtgtgggaa gaaaaagctt gtattctggt tgatcatctt      960

agggagccat tgtatataaa ggtatttgac tatgattttg gactacagga tgactttatg     1020

ggctcagcct ttctggatct gacacaattg gagttaaaca ggcccacaga tgtgaccctt     1080

actctgaaag atcctcatta tcctgaccat gatcttggaa tcattttgct ctcagtcatc     1140

cttaccccta aagaaggaga gtccagggat gtgacaatgc taatgaggaa gagttggaaa     1200

agatcaagta aggaactttc agaaaatgaa gtggttggat cttatttctc tgtgaagtct     1260

ctcttttgga ggacgtgcgg caggccagct cttcctgtcc tgggcttctg cagagcagag     1320

cttcagaatc cttattgcaa aaatgtacaa tttcagaccc aaagtttacg cctatcagac     1380

ctacacagaa aatcgcatct ttggagagga atagtcagca tcaccttgat tgaagggaga     1440

gacctcaagg ccatggattc caacgggttg agcgatccct acgtgaagtt ccggcttggg     1500

catcagaagt acaagagcaa gattatgcca aaaacgttga atcctcagtg gagggaacaa     1560

tttgattttc acctttatga agaaagagga ggagtcattg atatcactgc atgggacaaa     1620

gatgctggga aaagggatga tttcattggc aggtgccagg tcgacctgtc agccctcagt     1680

agggaacaga cgcacaagct ggagttgcag ctggaagagg gtgagggaca cctggtgctg     1740

ctggtcactc tgacagcatc agccacagtc agcatctctg acctgtctgt caactccctg     1800

gaggaccaga aggaacgaga ggagatatta aagagatata gcccattgag gatatttcac     1860

aacctgaaag atgtgggatt tctccaggtg aaagtcatca gagcggaagg gttaatggct     1920

gccgacgtca ctggaaaaag tgacccattt tgtgtggtag aactgaacaa cgatagactg     1980

ctaacacata ctgtctacaa aaatctcaat cctgagtgga ataaagtctt cacgttcaac     2040

attaaagata tccattcagt tcttgaagtg acagtttatg atgaagatcg ggatcgaagt     2100

gctgactttc tgggcaaagt tgctatacca ttgctgtcta ttcaaaatgg tgaacagaaa     2160

gcctacgtct tgaaaaacaa gcagctgaca gggccaacaa agggggtcat ctatcttgaa     2220

atagatgtga tttttaatgc tgtgaaagcc agcttacgaa cattaatacc caaagaacag     2280

aagtacattg aagaggaaaa cagactctct aaacagctgc tactaagaaa ctttatcaga     2340

atgaaacgtt gtgtcatggt gctggtaaat gctgcatact acgttaatag ttgctttgat     2400

tgggattcac ccccaaggag tctcgctgct tttgtgctct ttctctttgt tgtctggaac     2460

tttgagctct acatgatacc actggttttg ttgttactat tgacatggaa ctacttcttg     2520

ataatatcag ggaaagataa caggcaacgt gatacagtag tggaggacat gctagaggac     2580

gaggaagaag aagatgacaa agatgacaag gacagtgaaa aaaagggatt tataaataaa     2640

atctatgcca tccaggaggt atgtgtcagt gtccagaaca tcctagatga agtggcttcc     2700

tttggcgaaa ggataaagaa tactttcaac tggactgtcc cattcttaag ctggctggcc     2760

attgtagccc tctgtgtgtt cacagccatc ctgtactgca ttccgctgag atacattgtc     2820

cttgtctggg gcatcaataa atttacaaaa aagcttcgga gtccatatgc aattgataac     2880

aatgaactac ttgacttcct ttccagagtc ccttcagatg tacaagtggt gcaataccaa     2940

gaactgaaac cagatccttc tcatagccca tataaaagaa agaaaaacaa tcttggctag     3000


<210>  49
<211>  5574
<212>  DNA
<213>  Homo sapiens;

<400>  49
atggcaagaa agaagctgaa aaaatttact actttggaga ttgtgctcag tgttcttctg       60

cttgtgttgt ttatcatcag tattgttcta attgtgcttt tagccaaaga gtcactgaaa      120

tcaacagccc cagatcctgg gacaactggt accccagatc ctgggacaac tggtacccca      180

gatcctggaa caactggtac cacacatgct aggacaacgg gtcccccaga tcctggaaca      240

actggtacca ctcctgtttc tgctgaatgt ccagtggtaa atgaattgga acgaattaat      300

tgcatccctg accagccgcc aacaaaggcc acatgtgacc aacgtggctg ttgctggaat      360

ccccagggag ctgtaagtgt tccctggtgc tactattcca agaatcatag ctaccatgta      420

gagggcaacc ttgtcaacac aaatgcagga ttcacagccc ggttgaaaaa tctgccttct      480

tcaccagtgt ttggaagcaa tgttgacaat gttcttctca cagcagaata tcagacatct      540

aatcgtttcc actttaagtt gactgaccaa accaataaca ggtttgaagt gccccacgaa      600

cacgtgcagt ccttcagtgg aaatgctgct gcttctttga cctaccaagt tgaaatctcc      660

agacagccat ttagcatcaa agtgaccaga agaagcaaca atcgtgtttt gtttgactcg      720

agcattgggc ccctactgtt tgctgaccag ttcttgcagc tctccactcg actgcctagc      780

actaacgtgt atggcctggg agagcatgtg caccagcagt atcggcatga tatgaattgg      840

aagacctggc ccatatttaa cagagacaca actcccaatg gaaacggaac taatttgtat      900

ggtgcgcaga cattcttctt gtgccttgaa gatgctagtg gattgtcctt tggggtgttt      960

ctgatgaaca gcaatgccat ggaggttgtc cttcagcctg cgccagccat cacttaccgc     1020

accattgggg gcattctcga cttctatgtg ttcttgggaa acactccaga gcaagttgtt     1080

caagaatatc tagagctcat tgggcggcca gcccttccct cctactgggc gcttggattt     1140

cacctcagtc gttacgaata tggaacctta gacaacatga gggaagtcgt ggagagaaat     1200

cgcgcagcac agctccctta tgatgttcag catgctgata ttgattatat ggatgagaga     1260

agggacttca cttatgattc agtggatttt aaaggcttcc ctgaatttgt caacgagtta     1320

cacaataatg gacagaagct tgtcatcatt gtggatccag ccatctccaa caactcttcc     1380

tcaagtaaac cctatggccc atatgacagg ggttcagata tgaagatatg ggtgaatagt     1440

tcagatggag tgactccact cattggggag gtctggcctg gacaaactgt gtttcctgat     1500

tataccaatc ccaactgtgc tgtttggtgg acaaaggaat ttgagctttt tcacaatcaa     1560

gtagagtttg atggaatctg gattgatatg aatgaagtct ccaactttgt tgatggttcg     1620

gtctcaggat gttccacaaa caacctaaat aatcccccat tcactcccag aatcctggat     1680

gggtacctgt tctgcaagac tctctgtatg gatgcagtgc agcactgggg caagcagtat     1740

gacattcaca atctgtatgg ctactccatg gcggtcgcca cagcagaagc tgccaagact     1800

gtgttcccta ataagagaag cttcattctg acccgttcta cctttgcggg ctctggcaag     1860

tttgcagcac attggttagg agacaacact gccacctggg atgacctgag atggtccatc     1920

cctggcgtgc ttgagttcaa cctttttggc atcccaatgg tgggtcctga catatgtggc     1980

tttgctttgg acacccctga ggagctctgt aggcggtgga tgcagttggg tgcattttat     2040

ccgttttcta gaaatcacaa tggccaaggc tacaaggacc aggatcctgc ctcctttgga     2100

gctgactccc tgctgttgaa ttcctccagg cactacctta acatccgcta tactctattg     2160

ccctacctat acaccctctt cttccgtgct cacagccgag gggacacggt ggccaggccc     2220

cttttgcatg agttctacga ggacaacagc acttgggatg tgcaccaaca gttcttatgg     2280

gggcccggcc tcctcatcac tccagttctg gatgaaggtg cagagaaagt gatggcatat     2340

gtgcctgatg ctgtctggta tgactacgag actgggagcc aagtgagatg gaggaagcaa     2400

aaagtcgaga tggaacttcc tggagacaaa attggacttc accttcgagg aggctacatc     2460

ttccccacac agcagccaaa tacaaccact ctggccagtc gaaagaaccc tcttggtctt     2520

atcattgccc tagatgagaa caaagaagca aaaggagaac ttttctggga taatggggaa     2580

acgaaggata ctgtggccaa taaagtgtat cttttatgtg agttttctgt cactcaaaac     2640

cgcttggagg tgaatatttc acaatcaacc tacaaggacc ccaataattt agcatttaat     2700

gagattaaaa ttcttgggac ggaggaacct agcaatgtta cagtgaaaca caatggtgtc     2760

ccaagtcaga cttctcctac agtcacttat gattctaacc tgaaggttgc cattatcaca     2820

gatattgatc ttctcctggg agaagcatac acagtggaat ggagcataaa gataagggat     2880

gaagaaaaaa tagactgtta ccctgatgag aatggtgctt ctgccgaaaa ctgcactgcc     2940

cgtggctgta tctgggaggc atccaattct tctggagtcc ctttttgcta ttttgtcaac     3000

gacctatact ctgtcagtga tgttcagtat aattcccatg gggccacagc tgacatctcc     3060

ttaaagtctt ccgtttatgc caatgccttc ccctccacac ccgtgaaccc ccttcgcctg     3120

gatgtcactt accataagaa tgaaatgctg cagttcaaga tttatgatcc caacaagaat     3180

cggtatgaag ttccagtccc tctgaacata cccagcatgc catccagcac ccctgagggt     3240

caactctatg atgtgctcat taagaagaat ccatttggga ttgaaattcg ccggaagagt     3300

acaggcacta taatttggga ctctcagctc cttggcttta ccttcagtga catgtttatc     3360

cgcatctcca cccgccttcc ctccaagtac ctctatggct ttggggaaac tgagcacagg     3420

tcctatagga gagacttgga gtggcacact tgggggatgt tctcccgaga ccagccccca     3480

gggtacaaga agaattccta tggtgtccac ccctactaca tggggctgga ggaggacggc     3540

agtgcccatg gagtgctcct gctgaacagc aatgccatgg atgtgacgtt ccagcccctg     3600

cctgccttga cataccgcac cacaggggga gttctggact tttatgtgtt cttggggccg     3660

actccagagc ttgtcaccca gcagtacact gagttgattg gccggcctgt gatggtacct     3720

tactggtctt tggggttcca gctgtgtcgc tatggctacc agaatgactc tgagatcgcc     3780

agcttgtatg atgagatggt ggctgcccag atcccttatg atgtgcagta ctcagacatc     3840

gactacatgg agcggcagct ggacttcacc ctcagcccca agtttgctgg gtttccagct     3900

ctgatcaatc gcatgaaggc tgatgggatg cgggtcatcc tcattctgga tccagccatt     3960

tctggcaatg agacacagcc ttatcctgcc ttcactcggg gcgtggagga tgacgtcttc     4020

atcaaatacc caaatgatgg agacattgtc tggggaaagg tctggcctga ttttcctgat     4080

gttgttgtga atgggtctct agactgggac agccaagtgg agctatatcg agcttatgtg     4140

gccttcccag actttttccg taattcaact gccaagtggt ggaagaggga aatagaagaa     4200

ctatacaaca atccacagaa tccagagagg agcttgaagt ttgatggcat gtggattgat     4260

atgaatgaac catcaagctt cgtgaatggg gcagtttctc caggctgcag ggacgcctct     4320

ctgaaccacc ctccctacat gccacatttg gagtccaggg acaggggcct gagcagcaag     4380

accctttgta tggagagtca gcagatcctc ccagacggct ccctggtgca gcactacaac     4440

gtgcacaacc tgtatgggtg gtcccagacc agacccacat acgaagccgt gcaggaggtg     4500

acgggacagc gaggggtcgt catcacccgc tccacatttc cctcttctgg ccgctgggca     4560

ggacattggc tgggagacaa cacggccgca tgggatcagc tgaagaagtc tatcattggc     4620

atgatggagt tcagcctctt cggcatatcc tatacgggag cagatatctg tgggttcttt     4680

caagatgctg aatatgagat gtgtgttcgc tggatgcagc tgggggcctt ttaccccttc     4740

tcaagaaacc acaacaccat tgggaccagg agacaagacc ctgtgtcctg ggatgttgct     4800

tttgtgaata tttccagaac tgtcctgcag accagataca ccctgttgcc atatctgtat     4860

accttgatgc ataaggccca cacggagggc gtcactgttg tgcggcctct gctccatgag     4920

tttgtgtcag accaggtgac atgggacata gacagtcagt tcctgctggg cccagccttc     4980

ctggtcagcc ctgtcctgga gcgtaatgcc agaaatgtca ctgcatattt ccctagagcc     5040

cgctggtatg attactacac gggtgtggat attaatgcaa gaggagagtg gaagaccttg     5100

ccagcccctc ttgaccacat taatcttcat gtccgtgggg gctacatcct gccctggcaa     5160

gagcctgcac tgaacaccca cttaagccgc cagaaattca tgggcttcaa aattgccttg     5220

gatgatgaag gaactgctgg gggctggctc ttctgggatg atgggcaaag cattgatacc     5280

tatgggaaag gactctatta cttggccagc ttttctgcca gccagaatac gatgcaaagc     5340

catataattt tcaacaatta catcactggt acaaatcctt tgaaactggg ctacattgaa     5400

atctggggag tgggcagtgt ccccgttacc agtgtcagca tctctgtgag tggcatggtc     5460

ataacaccct ccttcaacaa tgaccccacg acacaggtat taagcatcga tgtgactgac     5520

agaaacatca gcctacataa ttttacttca ttgacgtgga taagcactct gtga           5574


<210>  50
<211>  2253
<212>  DNA
<213>  Homo sapiens;

<400>  50
atgggcaagt cagaaagtca gatggatata actgatatca acactccaaa gccaaagaag       60

aaacagcgat ggactccact ggagatcagc ctctcggtcc ttgtcctgct cctcaccatc      120

atagctgtga caatgatcgc actctatgca acctacgatg atggtatttg caagtcatca      180

gactgcataa aatcagctgc tcgactgatc caaaacatgg atgccaccac tgagccttgt      240

acagactttt tcaaatatgc ttgcggaggc tggttgaaac gtaatgtcat tcccgagacc      300

agctcccgtt acggcaactt tgacatttta agagatgaac tagaagtcgt tttgaaagat      360

gtccttcaag aacccaaaac tgaagatata gtagcagtgc agaaagcaaa agcattgtac      420

aggtcttgta taaatgaatc tgctattgat agcagaggtg gagaacctct actcaaactg      480

ttaccagaca tatatgggtg gccagtagca acagaaaact gggagcaaaa atatggtgct      540

tcttggacag ctgaaaaagc tattgcacaa ctgaattcta aatatgggaa aaaagtcctt      600

attaatttgt ttgttggcac tgatgataag aattctgtga atcatgtaat tcatattgac      660

caacctcgac ttggcctccc ttctagagat tactatgaat gcactggaat ctataaagag      720

gcttgtacag catatgtgga ttttatgatt tctgtggcca gattgattcg tcaggaagaa      780

agattgccca tcgatgaaaa ccagcttgct ttggaaatga ataaagttat ggaattggaa      840

aaagaaattg ccaatgctac ggctaaacct gaagatcgaa atgatccaat gcttctgtat      900

aacaagatga cattggccca gatccaaaat aacttttcac tagagatcaa tgggaagcca      960

ttcagctggt tgaatttcac aaatgaaatc atgtcaactg tgaatattag tattacaaat     1020

gaggaagatg tggttgttta tgctccagaa tatttaacca aacttaagcc cattcttacc     1080

aaatattctg ccagagatct tcaaaattta atgtcctgga gattcataat ggatcttgta     1140

agcagcctca gccgaaccta caaggagtcc agaaatgctt tccgcaaggc cctttatggt     1200

acaacctcag aaacagcaac ttggagacgt tgtgcaaact atgtcaatgg gaatatggaa     1260

aatgctgtgg ggaggcttta tgtggaagca gcatttgctg gagagagtaa acatgtggtc     1320

gaggatttga ttgcacagat ccgagaagtt tttattcaga ctttagatga cctcacttgg     1380

atggatgccg agacaaaaaa gagagctgaa gaaaaggcct tagcaattaa agaaaggatc     1440

ggctatcctg atgacattgt ttcaaatgat aacaaactga ataatgagta cctcgagttg     1500

aactacaaag aagatgaata cttcgagaac ataattcaaa atttgaaatt cagccaaagt     1560

aaacaactga agaagctccg agaaaaggtg gacaaagatg agtggataag tggagcagct     1620

gtagtcaatg cattttactc ttcaggaaga aatcagatag tcttcccagc cggcattctg     1680

cagcccccct tctttagtgc ccagcagtcc aactcattga actatggggg catcggcatg     1740

gtcataggac acgaaatcac ccatggcttc gatgacaatg gcagaaactt taacaaagat     1800

ggagacctcg ttgactggtg gactcaacag tctgcaagta actttaagga gcaatcccag     1860

tgcatggtgt atcagtatgg aaacttttcc tgggacctgg caggtggaca gcaccttaat     1920

ggaattaata cactgggaga aaacattgct gataatggag gtcttggtca agcatacaga     1980

gcctatcaga attatattaa aaagaatggc gaagaaaaat tacttcctgg acttgaccta     2040

aatcacaaac aactattttt cttgaacttt gcacaggtgt ggtgtggaac ctataggcca     2100

gagtatgcgg ttaactccat taaaacagat gtgcacagtc caggcaattt caggattatt     2160

gggactttgc agaactctgc agagttttca gaagcctttc actgccgcaa gaattcatac     2220

atgaatccag aaaagaagtg ccgggtttgg tga                                  2253


<210>  51
<211>  6192
<212>  DNA
<213>  Homo sapiens;

<400>  51
atggttttgg atgaccttcc aaacttagaa gacatctata cttccttgtg ttcatcaaca       60

atggaagact cagagatgga ttttgactct ggactagaag atgatgacac aaaaagtgat      120

agtattttgg aggattccac aatttttgtg gccttcaaag gaaatataga tgataaagac      180

ttcaaatgga aattagatgc aatattgaaa aacgtgccca atttgttaca catggagtcc      240

agcaagctaa aagtacagaa ggtggagccc tggaacagcg tgcgtgtgac attcaacatc      300

ccccgggaag cagcggagcg gctacggatc cttgctcaga gcaacaacca gcagcttcgg      360

gatttaggga ttctctccgt tcagattgaa ggggaaggtg ctattaacct ggctttggct      420

cagaaccgaa gccaagatgt gagaatgaat ggacccatgg gagctggaaa ttcagttagg      480

atggaggcgg gatttcctat ggcaagtggt ccaggaataa taaggatgaa caaccctgcc      540

actgttatga tacccccggg tggaaatgtg tcatcttcca tgatggcacc aggccccaat      600

ccagagctgc agcccaggac tcctcgccct gcttctcagt cagatgcaat ggatccactc      660

ctctctgggc tccatataca gcagcaaagt catccctcag gatctttagc tcccccacat      720

cacccaatgc agcctgtctc tgtgaacaga caaatgaacc cagctaattt tccccagctg      780

cagcagcagc agcaacaaca acaacagcag cagcagcagc agcagcagca acaacagcaa      840

cagcagcaac aacagttgca ggcaagaccc ccacagcaac atcagcagca acagccacag      900

ggaattcgac cccagtttac tgccccaact caggtgcctg ttcctccagg ctggaaccag      960

ctgccttctg gagcccttca acctcctcca gcccagggtt ctctgggcac aatgactgca     1020

aaccaagggt ggaagaaggc tcccttgccc ggcccaatgc aacagcaact ccaggcaaga     1080

ccatccttag ccacggtaca gacgccttcc caccctcccc ctccatatcc ctttggcagc     1140

cagcaagcct cacaagccca cacaaacttt cctcagatga gcaacccagg ccagttcaca     1200

gctcctcaga tgaagagttt gcagggaggg ccctctaggg tcccaactcc cttgcagcag     1260

ccccacctca ccaacaagtc tcctgcctcc tcaccctcct ccttccagca gggatcccct     1320

gcatcctccc caacggttaa ccaaactcag cagcagatgg gaccaaggcc acctcaaaat     1380

aacccacttc cccagggatt tcagcagcct gtcagctctc cgggtcggaa tcctatggtt     1440

caacagggaa atgtgccacc taacttcatg gtgatgcagc agcaaccacc aaaccagggg     1500

ccacagagtt tacatccagg cctaggagga atgcctaaac gcctcccacc tggcttctca     1560

gcaggacagg ccaatccgaa ctttatgcaa ggtcaggtgc cttcgaccac agcaaccacc     1620

cctgggaatt caggagcccc tcagctgcaa gcaaatcaaa atgtccagca tgcaggtggt     1680

caaggagctg gtcctcctca aaaccagatg caggtgtccc acgggccgcc aaatatgatg     1740

cagcccagcc tcatgggaat tcatggcaac atgaacaatc agcaggctgg tacttctggg     1800

gttcctcaag tgaacctcag caacatgcaa ggccagcccc agcagggccc accatctcag     1860

ctgatgggca tgcaccagca aatcgtgccc tcccagggcc agatggtcca gcaacaagga     1920

accttgaacc ctcagaaccc tatgatcctt tcaagggccc agcttatgcc acagggccag     1980

atgatggtga accccccgag ccaaaatctt gggccctcgc cccaaaggat gaccccaccc     2040

aagcagatgc tttcccagca gggcccacaa atgatggcgc cacataacca gatgatgggg     2100

cctcaggggc aggttttgct ccaacagaac ccaatgatag agcagattat gaccaatcaa     2160

atgcagggga ataagcagca gtttaacact cagaaccagt ccaatgtcat gccgggacca     2220

gcccagataa tgaggggacc aactccaaac atgcaaggaa atatggtgca gtttacggga     2280

cagatgtcag gacagatgct gccccagcaa gggcctgtga acaacagtcc atctcaggtt     2340

atgggcattc agggacaggt cctgcggcca ccagggccca gcccacacat ggcccagcag     2400

catggtgatc ctgctactac agcaaataac gatgtcagtt tatctcagat gatgcctgat     2460

gttagcattc aacaaaccaa catggtcccc cctcatgtgc aggccatgca gggaaacagt     2520

gcctcgggaa accacttctc aggccatggg atgtctttca atgcaccttt cagtggagct     2580

cccaatggaa atcagatgtc ctgtggtcaa aatccaggct tcccagtcaa taaggatgtc     2640

acgctaacga gcccattgtt ggtcaactta ttgcagagtg acatatctgc aggccatttt     2700

ggggtaaaca ataagcaaaa taataccaac gcaaataaac cgaagaagaa gaaaccccct     2760

cggaagaaga aaaatagtca gcaagatcta aacaccccag atactcgccc agctggtctg     2820

gaagaggctg atcagccacc gttgcctgga gaacaaggaa ttaacttgga taactcaggc     2880

cctaaactgc cagaattttc aaaccggcca ccaggttatc cttctcaacc agttgaacag     2940

aggccacttc agcagatgcc tcctcaactc atgcagcatg tggcaccccc accacagcca     3000

ccacagcagc agccacagcc acaactgcct cagcagcagc agccaccacc tcccagtcag     3060

ccacagtctc agcagcagca gcagcagcag caacaaatga tgatgatgct catgatgcag     3120

caggatccca aatcagttag gcttccagtc tctcaaaatg tccatcctcc aaggggcccc     3180

ctgaaccccg actcccagag aatgcccatg caacagagtg gcagtgtgcc tgtcatggtc     3240

agtctgcaag gacctgcctc cgtgccacca tcacctgata aacaaagaat gccaatgcct     3300

gtgaatactc ccttgggaag caattcaagg aaaatggtct atcaggagag cccgcagaat     3360

ccttccagct cgccactggc ggagatggcc tcactccctg aagcaagtgg cagtgaagca     3420

ccatctgtcc caggaggccc aaacaacatg ccttcacatg tagtacttcc ccagaatcag     3480

ttaatgatga cagggccaaa acctggacca tcgccccttt cagcaactca aggtgcaact     3540

ccccagcaac cccctgtaaa ttccctgccc agctctcacg gccaccactt cccaaatgtg     3600

gctgcgccaa cccagacatc taggcccaaa acaccaaaca gagccagccc cagaccctat     3660

tatcctcaga cacccaacaa ccgccctccc agcacagaac cttcagaaat cagtctgtca     3720

ccagaaagac tcaatgcctc catagcagga ctcttccctc cacagattaa tattccttta     3780

cctcctaggc caaatttaaa caggggcttt gatcaacaag gcctaaatcc aacaactttg     3840

aaggccatcg ggcaagcacc ttcaaatctt accatgaatc cttccaattt tgctacccca     3900

caaactcaca aattagattc tgtggtagtg aattctggaa agcagtctaa ttctggagca     3960

acaaaacggg caagtccaag caacagtcgc aggtctagtc ctgggtccag taggaaaacc     4020

actccaagcc ctgggaggca aaattcaaaa gcccctaaac ttactctggc ctctcagaca     4080

aatgcagccc tattgcagaa tgtggagttg ccgagaaatg tattggtcag tcccactcct     4140

ctggccaatc cccctgtacc tgggagcttt cctaacaaca gtgggctgaa tcctcagaat     4200

tctactgtgt ctgtggctgc agttgggggt gttgttgagg ataacaagga gagcttgaat     4260

gtgcctcagg acagtgattg ccagaattcc cagagtagga aggaacaggt aaacattgaa     4320

ctaaaagcag tccctgccca agaagttaaa atggttgtcc ctgaagatca gtccaaaaag     4380

gatgggcagc cttcggatcc taacaaactt cccagtgtcg aagagaacaa aaatttggtg     4440

tctcctgcta tgagggaagc accaacatcg ttaagtcaac ttcttgacaa ctctggagct     4500

cccaatgtga caattaaacc ccctgggctt acagatctgg aagtaacacc tccagtagtt     4560

tctggggagg acctcaaaaa agcatctgtc attcccacac tgcaggatct gtcttcttct     4620

aaagaacctt ctaattccct aaacttacct cacagtaatg agctgtgttc atcccttgtg     4680

catcccgaat tgagtgaggt cagttctaac gttgcaccaa gcatccctcc agtaatgtca     4740

agacctgtta gctcttcctc catttccact cccttgcccc caaatcaaat aactgtattt     4800

gtcacttcca atcccatcac aacttcagct aacacatcag cagctttgcc aactcacttg     4860

cagtctgcat tgatgtcaac agttgtcaca atgcccaatg cgggtagcaa ggttatggtt     4920

tctgagggac agtcagctgc tcagtctaat gcccggcctc agttcattac acctgtcttt     4980

atcaattcat cctcaataat tcaggttatg aaaggatcac agccaagcac aattcctgca     5040

gccccactga caaccaactc tggcctgatg cctccctctg ttgcagttgt tggcccttta     5100

cacatacctc agaacataaa attttcttct gctcctgtac cgcctaatgc cctctccagt     5160

agtcctgctc caaacatcca gacaggtcga cctttggtcc ttagctcacg agccacccct     5220

gttcagcttc cttcccctcc ttgtacgtct tctccagttg tcccttctca tccccctgtg     5280

cagcaagtga aagaattgaa tccagatgag gctagccctc aggtgaacac ctcagcagat     5340

cagaacactc ttccctcttc acagtcaacc acaatggttt ctcccctttt gaccaatagt     5400

ccagggtcct ctggcaaccg gcgaagccca gtctcgtcta gtaagggcaa aggaaaagtg     5460

gacaaaattg gccaaatttt gttgaccaag gcatgtaaga aagttacagg ctctcttgag     5520

aaaggggaag aacaatatgg tgcagatgga gagactgaag gccaagggct agacaccaca     5580

gctccggggc tcatgggaac agagcagtta tccacagagc tggacagtaa aaccccaacg     5640

cccccagcac ccactctgct aaaaatgacc tctagccctg tgggcccggg cactgcctca     5700

gcaggaccca gcttacctgg cggtgctctc cccaccagtg tacgctcgat agtaaccact     5760

ctggtaccct ccgagctcat ctccgccgta ccgaccacaa aaagcaatca tggtggcata     5820

gcatctgagt cacttgcggg tggcctagtg gaggagaagg tgggatccca tccagaactt     5880

ctacccagca tagccccgtc gcagaattta gtctcaaagg aaacttcaac cacagcactg     5940

caggcctctg ttgccagacc agagctggag gtaaatgctg ccatagtctc tggacaaagc     6000

agtgagccca aagagatagt tgaaaagtcc aaaatcccag gccgaagaaa ctcccgaact     6060

gaagagccaa ctgtggcctc tgaaagtgtg gaaaatggac atcgtaaacg atcttctcga     6120

cctgcttcag cctccagctc tactaaagac ataaccagtg cggtgcaatc caagcgaaga     6180

aaatccaagt aa                                                         6192


<210>  52
<211>  1287
<212>  DNA
<213>  Homo sapiens;

<400>  52
atgtattcgt ccccgctctg cctcacccag gatgagttcc acccgttcat cgaggccctg       60

ctgcctcacg tccgcgcctt cgcctacacc tggttcaacc tgcaggcgcg gaagcgcaag      120

tacttcaaga agcacgagaa gcggatgtcg aaggacgagg agcgtgcggt caaggacgag      180

ctgctgggcg agaagcccga ggtcaagcag aagtgggcgt cgcggctgct ggccaagctg      240

cgcaaggaca tccggcccga gtgccgcgag gacttcgtgc tgagcatcac cggcaagaag      300

gcgccgggct gcgtgctctc caaccccgac cagaagggca agatgcggcg catcgactgt      360

ctccggcagg cggacaaggt gtggcggctg gacctggtca tggtcatcct gttcaagggc      420

atcccgctgg agagcaccga cggcgagcgc ctggtcaagg ctgcgcagtg cggtcacccg      480

gtcctgtgcg tgcagccgca ccacattggc gtggccgtca aggagctgga cctctacctg      540

gcctacttcg tgcgtgagcg agatgcagag caaagcggca gtccccggac agggatgggc      600

tctgaccagg aggacagcaa gcccatcacg ctggacacga ccgacttcca ggagagcttt      660

gtcacctccg gcgtgttcag cgtcactgag ctcatccaag tgtcccggac acccgtggtg      720

actggaacag gacccaactt ctccctgggg gagctgcagg ggcacctggc atacgacctg      780

aacccagcca gcactggcct cagaagaacg ctgcccagca cctcctccag tgggagcaag      840

cggcacaaat cgggctcgat ggaggaagac gtggacacga gccctggcgg cgattactac      900

acttcgccca gctcgcccac gagtagcagc cgcaactgga cggaggacat ggaaggaggc      960

atctcgtccc cggtgaagaa gacagagatg gacaagtcac cattcaacag cccgtccccc     1020

caggactctc cccgcctctc cagcttcacc cagcaccacc ggcccgtcat cgccgtgcac     1080

agcgggatcg cccggagccc acacccgtcc tccgctctgc atttccctac gacgtccatc     1140

ctaccccaga cggcctccac ctacttcccc cacacggcca tccgctaccc acctcatctc     1200

aacccccagg acccgctcaa agatcttgtc tcgctggcct gcgacccagc cagccagcaa     1260

cctggaccgt cctggtatct gggatag                                         1287


<210>  53
<211>  4290
<212>  DNA
<213>  Homo sapiens;

<400>  53
atggctggcg gagcctgggg ccgcctggcc tgttacttgg agttcctgaa gaaggaggag       60

ctgaaggagt tccagcttct gctcgccaat aaagcgcact ccaggagctc ttcgggtgag      120

acacccgctc agccagagaa gacgagtggc atggaggtgg cctcgtacct ggtggctcag      180

tatggggagc agcgggcctg ggacctagcc ctccatacct gggagcagat ggggctgagg      240

tcactgtgcg cccaagccca ggaaggggca ggccactctc cctcattccc ctacagccca      300

agtgaacccc acctggggtc tcccagccaa cccacctcca ccgcagtgct aatgccctgg      360

atccatgaat tgccggcggg gtgcacccag ggctcagaga gaagggtttt gagacagctg      420

cctgacacat ctggacgccg ctggagagaa atctctgcct cactcctcta ccaagctctt      480

ccaagctccc cagaccatga gtctccaagc caggagtcac ccaacgcccc cacatccaca      540

gcagtgctgg ggagctgggg atccccacct cagcccagcc tagcacccag agagcaggag      600

gctcctggga cccaatggcc tctggatgaa acgtcaggaa tttactacac agaaatcaga      660

gaaagagaga gagagaaatc agagaaaggc aggcccccat gggcagcggt ggtaggaacg      720

cccccacagg cgcacaccag cctacagccc caccaccacc catgggagcc ttctgtgaga      780

gagagcctct gttccacatg gccctggaaa aatgaggatt ttaaccaaaa attcacacag      840

ctgctacttc tacaaagacc tcaccccaga agccaagatc ccctggtcaa gagaagctgg      900

cctgattatg tggaggagaa tcgaggacat ttaattgaga tcagagactt atttggccca      960

ggcctggata cccaagaacc tcgcatagtc atactgcagg gggctgctgg aattgggaag     1020

tcaacactgg ccaggcaggt gaaggaagcc tgggggagag gccagctgta tggggaccgc     1080

ttccagcatg tcttctactt cagctgcaga gagctggccc agtccaaggt ggtgagtctc     1140

gctgagctca tcggaaaaga tgggacagcc actccggctc ccattagaca gatcctgtct     1200

aggccagagc ggctgctctt catcctcgat ggtgtagatg agccaggatg ggtcttgcag     1260

gagccgagtt ctgagctctg tctgcactgg agccagccac agccggcgga tgcactgctg     1320

ggcagtttgc tggggaaaac tatacttccc gaggcatcct tcctgatcac ggctcggacc     1380

acagctctgc agaacctcat tccttctttg gagcaggcac gttgggtaga ggtcctgggg     1440

ttctctgagt ccagcaggaa ggaatatttc tacagatatt tcacagatga aaggcaagca     1500

attagagcct ttaggttggt caaatcaaac aaagagctct gggccctgtg tcttgtgccc     1560

tgggtgtcct ggctggcctg cacttgcctg atgcagcaga tgaagcggaa ggaaaaactc     1620

acactgactt ccaagaccac cacaaccctc tgtctacatt accttgccca ggctctccaa     1680

gctcagccat tgggacccca gctcagagac ctctgctctc tggctgctga gggcatctgg     1740

caaaaaaaga cccttttcag tccagatgac ctcaggaagc atgggttaga tggggccatc     1800

atctccacct tcttgaagat gggtattctt caagagcacc ccatccctct gagctacagc     1860

ttcattcacc tctgtttcca agagttcttt gcagcaatgt cctatgtctt ggaggatgag     1920

aaggggagag gtaaacattc taattgcatc atagatttgg aaaagacgct agaagcatat     1980

ggaatacatg gcctgtttgg ggcatcaacc acacgtttcc tattgggcct gttaagtgat     2040

gagggggaga gagagatgga gaacatcttt cactgccggc tgtctcaggg gaggaacctg     2100

atgcagtggg tcccgtccct gcagctgctg ctgcagccac actctctgga gtccctccac     2160

tgcttgtacg agactcggaa caaaacgttc ctgacacaag tgatggccca tttcgaagaa     2220

atgggcatgt gtgtagaaac agacatggag ctcttagtgt gcactttctg cattaaattc     2280

agccgccacg tgaagaagct tcagctgatt gagggcaggc agcacagatc aacatggagc     2340

cccaccatgg tagtcctgtt caggtgggtc ccagtcacag atgcctattg gcagattctc     2400

ttctccgtcc tcaaggtcac cagaaacctg aaggagctgg acctaagtgg aaactcgctg     2460

agccactctg cagtgaagag tctttgtaag accctgagac gccctcgctg cctcctggag     2520

accctgcggt tggctggctg tggcctcaca gctgaggact gcaaggacct tgcctttggg     2580

ctgagagcca accagaccct gaccgagctg gacctgagct tcaatgtgct cacggatgct     2640

ggagccaaac acctttgcca gagactgaga cagccgagct gcaagctaca gcgactgcag     2700

ctggtcagct gtggcctcac gtctgactgc tgccaggacc tggcctctgt gcttagtgcc     2760

agccccagcc tgaaggagct agacctgcag cagaacaacc tggatgacgt tggcgtgcga     2820

ctgctctgtg aggggctcag gcatcctgcc tgcaaactca tacgcctggg gctggaccag     2880

acaactctga gtgatgagat gaggcaggaa ctgagggccc tggagcagga gaaacctcag     2940

ctgctcatct tcagcagacg gaaaccaagt gtgatgaccc ctactgaggg cctggatacg     3000

ggagagatga gtaatagcac atcctcactc aagcggcaga gactcggatc agagagggcg     3060

gcttcccatg ttgctcaggc taatctcaaa ctcctggacg tgagcaagat cttcccaatt     3120

gctgagattg cagaggaaag ctccccagag gtagtaccgg tggaactctt gtgcgtgcct     3180

tctcctgcct ctcaagggga cctgcatacg aagcctttgg ggactgacga tgacttctgg     3240

ggccccacgg ggcctgtggc tactgaggta gttgacaaag aaaagaactt gtaccgagtt     3300

cacttccctg tagctggctc ctaccgctgg cccaacacgg gtctctgctt tgtgatgaga     3360

gaagcggtga ccgttgagat tgaattctgt gtgtgggacc agttcctggg tgagatcaac     3420

ccacagcaca gctggatggt ggcagggcct ctgctggaca tcaaggctga gcctggagct     3480

gtggaagctg tgcacctccc tcactttgtg gctctccaag ggggccatgt ggacacatcc     3540

ctgttccaaa tggcccactt taaagaggag gggatgctcc tggagaagcc agccagggtg     3600

gagctgcatc acatagttct ggaaaacccc agcttctccc ccttgggagt cctcctgaaa     3660

atgatccata atgccctgcg cttcattccc gtcacctctg tggtgttgct ttaccaccgc     3720

gtccatcctg aggaagtcac cttccacctc tacctgatcc caagtgactg ctccattcgg     3780

aaggaactgg agctctgcta tcgaagccct ggagaagacc agctgttctc ggagttctac     3840

gttggccact tgggatcagg gatcaggctg caagtgaaag acaagaaaga tgagactctg     3900

gtgtgggagg ccttggtgaa accaggagat ctcatgcctg caactactct gatccctcca     3960

gcccgcatag ccgtaccttc acctctggat gccccgcagt tgctgcactt tgtggaccag     4020

tatcgagagc agctgatagc ccgagtgaca tcggtggagg ttgtcttgga caaactgcat     4080

ggacaggtgc tgagccagga gcagtacgag agggtgctgg ctgagaacac gaggcccagc     4140

cagatgcgga agctgttcag cttgagccag tcctgggacc ggaagtgcaa agatggactc     4200

taccaagccc tgaaggagac ccatcctcac ctcattatgg aactctggga gaagggcagc     4260

aaaaagggac tcctgccact cagcagctga                                      4290


<210>  54
<211>  1281
<212>  DNA
<213>  Homo sapiens;

<400>  54
atgactcctc tctgcctcaa ttgctctgtc ctccctggag acctgtaccc agggggtgca       60

aggaacccca tggcttgcaa tggcagtgcg gccagggggc actttgaccc tgaggacttg      120

aacctgactg acgaggcact gagactcaag tacctggggc cccagcagac agagctgttc      180

atgcccatct gtgccacata cctgctgatc ttcgtggtgg gcgctgtggg caatgggctg      240

acctgtctgg tcatcctgcg ccacaaggcc atgcgcacgc ctaccaacta ctacctcttc      300

agcctggccg tgtcggacct gctggtgctg ctggtgggcc tgcccctgga gctctatgag      360

atgtggcaca actacccctt cctgctgggc gttggtggct gctatttccg cacgctactg      420

tttgagatgg tctgcctggc ctcagtgctc aacgtcactg ccctgagcgt ggaacgctat      480

gtggccgtgg tgcacccact ccaggccagg tccatggtga cgcgggccca tgtgcgccga      540

gtgcttgggg ccgtctgggg tcttgccatg ctctgctccc tgcccaacac cagcctgcac      600

ggcatccggc agctgcacgt gccctgccgg ggcccagtgc cagactcagc tgtttgcatg      660

ctggtccgcc cacgggccct ctacaacatg gtagtgcaga ccaccgcgct gctcttcttc      720

tgcctgccca tggccatcat gagcgtgctc tacctgctca ttgggctgcg actgcggcgg      780

gagaggctgc tgctcatgca ggaggccaag ggcaggggct ctgcagcagc caggtccaga      840

tacacctgca ggctccagca gcacgatcgg ggccggagac aagtgaccaa gatgctgttt      900

gtcctggtcg tggtgtttgg catctgctgg gccccgttcc acgccgaccg cgtcatgtgg      960

agcgtcgtgt cacagtggac agatggcctg cacctggcct tccagcacgt gcacgtcatc     1020

tccggcatct tcttctacct gggctcggcg gccaaccccg tgctctatag cctcatgtcc     1080

agccgcttcc gagagacctt ccaggaggcc ctgtgcctcg gggcctgctg ccatcgcctc     1140

agaccccgcc acagctccca cagcctcagc aggatgacca caggcagcac cctgtgtgat     1200

gtgggctccc tgggcagctg ggtccacccc ctggctggga acgatggccc agaggcgcag     1260

caagagaccg atccatcctg a                                               1281


<210>  55
<211>  1074
<212>  DNA
<213>  Homo sapiens;

<400>  55
atgcagagtg tgcagagcac gagcttttgt ctccgaaagc agtgcctttg cctgaccttc       60

ctgcttctcc atctcctggg acaggtcgct gcgactcagc gctgccctcc ccagtgcccg      120

ggccggtgcc ctgcgacgcc gccgacctgc gcccccgggg tgcgcgcggt gctggacggc      180

tgctcatgct gtctggtgtg tgcccgccag cgtggcgaga gctgctcaga tctggagcca      240

tgcgacgaga gcagtggcct ctactgtgat cgcagcgcgg accccagcaa ccagactggc      300

atctgcacgg cggtagaggg agataactgt gtgttcgatg gggtcatcta ccgcagtgga      360

gagaaatttc agccaagctg caaattccag tgcacctgca gagatgggca gattggctgt      420

gtgccccgct gtcagctgga tgtgctactg cctgagccta actgcccagc tccaagaaaa      480

gttgaggtgc ctggagagtg ctgtgaaaag tggatctgtg gcccagatga ggaggattca      540

ctgggaggcc ttacccttgc agcttacagg ccagaagcca ccctaggagt agaagtctct      600

gactcaagtg tcaactgcat tgaacagacc acagagtgga cagcatgctc caagagctgt      660

ggtatggggt tctccacccg ggtcaccaat aggaaccgtc aatgtgagat gctgaaacag      720

actcggctct gcatggtgcg gccctgtgaa caagagccag agcagccaac agataagaaa      780

ggaaaaaagt gtctccgcac caagaagtca ctcaaagcca tccacctgca gttcaagaac      840

tgcaccagcc tgcacaccta caagcccagg ttctgtgggg tctgcagtga tggccgctgc      900

tgcactcccc acaataccaa aaccatccag gcagagtttc agtgctcccc agggcaaata      960

gtcaagaagc cagtgatggt cattgggacc tgcacctgtc acaccaactg tcctaagaac     1020

aatgaggcct tcctccagga gctggagctg aagactacca gagggaaaat gtaa           1074


<210>  56
<211>  4284
<212>  DNA
<213>  Homo sapiens;

<400>  56
atgttgttac cctcggacgt agcccggctt gtattgggtt acttacagca agaaaacctc       60

atttctacct gccagacttt tattttggaa agttcagatt taaaagaata tgcagaacat      120

tgtacagatg aagggtttat tccagcctgc ttactgtcct tatttggaaa aaacttgaca      180

acaattttaa atgagtatgt agctatgaaa acaaaagaaa catcaaataa tgtcccagca      240

ataatgtcat ctctatggaa gaaattggac catacacttt ctcagatcag gagcatgcaa      300

agttccccaa ggtttgctgg cagtcagaga gcccgaacga gaactggaat tgcagaaatc      360

aaacggcaga gaaagcttgc atctcaaaca gctccagcca gtgcagagtt gctcacttta      420

ccttaccttt caggacagtt taccactcct ccttccacag gtacacaggt tactcgacca      480

agtggccaaa tttcagatcc atcgaggtca tattttgtag tggtcaacca ctcacagtca      540

caagatactg taaccactgg agaagcttta aatgtcattc ctggtgctca ggaaaagaaa      600

gcacatgcca gtttaatgtc tcccggtaga cgcaaaagtg aatctcagag aaaaagtacc      660

actttgtctg gccctcattc aacaatacgg aatttccaag atccaaacgc ttttgcagta      720

gaaaaacaaa tggttattga aaatgcacga gaaaaaatac taagcaacaa atctcttcaa      780

gaaaagctag cagaaaacat aaataaattt ttaactagtg ataacaatat tgcccaagta      840

cctaagcaaa cagataacaa ccctacggag ccagagactt caattgatga attcctagga      900

cttccgagtg aaattcacat gtctgaagaa gctatacagg acatattgga acagacagaa      960

tcagacccag catttcaggc actctttgat ctctttgact atggcaaaac aaagaataat     1020

aaaaatatat cacaaagtat ttccagtcaa cctatggaat ccaatcccag tatagtctta     1080

gcagatgaaa ctaatctagc agttaaaggt tcttttgaaa cagaagaatc tgatggtcag     1140

tctggtcagc ccgctttttg tacatcctat cagaatgatg acccattaaa tgctttgaag     1200

aatagcaaca accatgatgt gcttagacaa gaagaccagg aaaatttttc ccaaataagt     1260

accagcatac agaaaaaggc ctttaaaaca gctgtaccca ctgaacagaa gtgtgacatt     1320

gacattacct ttgagtccgt gcctaatttg aatgacttta accaaagagg gaattctaat     1380

gctgaatgta atccacattg tgctgaatta tacaccaatc agatgtccac tgaaactgaa     1440

atggctatag ggattgaaaa gaactctttg tcttcaaatg taccgagtga atctcagtta     1500

cagcctgatc agcctgatat accaataact tcatttgttt cacttggttg tgaagctaac     1560

aatgaaaact taattctctc tgggaagagt tctcaacttt tatcccaaga tacttcatta     1620

actggaaagc catctaaaaa aagtcaattt tgtgaaaatt ctaatgatac agtaaaactt     1680

aaaattaatt ttcatggttc caagtcatca gattctagtg aagttcacaa gagtaaaata     1740

gaaattaatg tgttagaacc agttatgtca cagctatcaa attgccaaga taattcttgt     1800

cttcaaagtg aaatactacc tgtgtctgtt gaaagttcac atttaaatgt atctggacaa     1860

gtagaaattc atcttggaga ttcgctgtct tctactaaac aaccatctaa tgattcagca     1920

tctgttgagt taaatcatac agaaaatgaa gctcaggcat ccaagtctga gaattcacag     1980

gagccttcat cttctgtaaa agaagagaat actatttttc tctctttagg tggaaatgct     2040

aactgtgaga aagttgcact gacgcctcca gaaggcactc ctgtagaaaa cagtcactct     2100

cttcctccag aatctgtgtg ttcttcagtg ggagattctc accctgagtc ccaaaatact     2160

gatgataaac cttctagcaa caactcagca gagatagatg catcaaatat cgtctctctc     2220

aaagttatca ttagtgatga tccatttgtt tcctcagata ctgaacttac cagtgctgtt     2280

tctagtatta atggagaaaa cctgccaact ataatcttgt cttctcctac taaatcacct     2340

actaaaaatg cagaactagt taaatgccta tcttcagaag aaactgtagg tgctgttgta     2400

tatgccgaag taggggattc agcctcaatg gaacagagtc ttttaacatt caaatctgaa     2460

gactctgcag taaacaatac tcagaatgaa gatggcattg ctttttcagc taatgttaca     2520

ccatgtgttt ccaaggatgg aggatatata cagttgatgc cagccacaag cacagctttt     2580

ggcaattcaa ataacattct gatagctacc tgtgtgactg atccaacagc gttaggaaca     2640

tctgtaagtc agtctaatgt agtggtgttg cctggaaatt ctgcacctat gactgctcaa     2700

cctctaccac ctcagttaca gacaccacca aggtcaaaca gtgtatttgc tgtcaaccaa     2760

gctgtgtcac caaacttttc acaaggatct gccataataa ttgcctctcc agtccagcct     2820

gtactccaag gaatggtagg gatgatccca gtatctgtgg ttggacagaa tggaaataac     2880

ttttctactc ctcctcggca ggttcttcat atgcctttga cagcacctgt atgcaataga     2940

agtatccctc aattccccgt ccctccaaaa tctcagaagg ctcagggact aagaaacaag     3000

ccttgtatag gaaaacaagt aaataatttg gtggattcgt caggtcattc agttggatgt     3060

catgcacaaa aaactgaagt ttctgacaaa agtattgcca cagatcttgg gaaaaaatca     3120

gaagaaacca cagttccctt cccagaagag agtatagttc cagctgctaa accatgccac     3180

agacgtgtac tctgtttcga cagcactact gctcctgtgg caaatacgca ggggccaaac     3240

cataagatgg tgtcccaaaa caaagaaagg aatgcagtct cttttcctaa tcttgactca     3300

cccaatgtgt cctccacctt aaaaccccct tctaataatg ctatcaaaag agagaaagag     3360

aagcctcctc tgcctaagat tttatctaaa tcggaaagtg ccattagccg gcataccacc     3420

ataagagaaa ctcaatcaga aaagaaagtt tcaccaacag aaattgtgct tgaatctttc     3480

cataaagcaa cagctaataa ggagaatgaa ttatgcagcg atgtagaaag acagaaaaat     3540

ccagaaaatt caaaactatc tattgggcag caaaatgggg gtttgcgaag tgagaaatct     3600

atagcttcac tgcaagaaat gaccaaaaaa caaggcacat cttcaaacaa taaaaatgta     3660

ctttcagtag gtacagctgt gaaggatcta aaacaagaac aaactaaatc cgccagttct     3720

ttgattacca cagaaatgtt acaggatata cagaggcaca gctcagtaag taggcttgct     3780

gatagtagtg atttacctgt gccccggaca cctggctcag gggcagggga aaaacataaa     3840

gaagaaccta tagatattat caaggccccc tctagtaggc gtttcagtga agacagtagt     3900

acatcaaaag taatggtccc tcctgtcacc ccagacttgc ctgcctgcag ccctgccagt     3960

gaaacaggaa gtgaaaacag tgtaaatatg gctgcccaca cattaatgat tctctccagg     4020

gcagccattt ctaggactac ttcagcaact cctctgaaag ataacacaca acagtttaga     4080

gcatcttcaa ggagcaccac aaaaaagcgg aaaattgagg aattagatga acgtgagcga     4140

aactctcgtc cttctagtaa aaatcttaca aattcatcaa taccaatgaa aaagaagaaa     4200

attaagaaaa agaagcttcc cagttcattt ccagcaggaa tggatgtaga caaatttttg     4260

ttatcattgc attatgatga gtaa                                            4284


<210>  57
<211>  3867
<212>  DNA
<213>  Homo sapiens;

<400>  57
atgggcagcc ccgagggccg cttccacttt gccatcgacc gtgggggtac cttcacagac       60

gtctttgccc agtgcccagg ggggcacgtg cgggtcttaa aactgctctc agaggaccct      120

gccaactatg cggacgcgcc aaccgaaggc atccgccgca tcctggagca ggaggccggc      180

atgctcctgc cccgggacca gccgctggac tccagtcata tcgccagcat ccgcatgggc      240

accacagtgg ccaccaacgc actgctggag cggaaggggg agcgggtggc gctgctggtg      300

acacgtggct tccgagacct gctgcacatt ggcacccaag cccgtgggga cctctttgac      360

ctggccgtgc ccatgcctga ggtgctgtat gaagaggtgc tggaggtgga cgaacgcgtg      420

gtgctgcacc gtggagaggc gggcaccggg acgcctgtga aaggccgcac gggggacctg      480

ctggaagtgc agcagcctgt ggacctgggg gccctgcgtg ggaagctgga ggggctgcta      540

tctcgaggca tccgcagcct ggctgtggtg ctcatgcact cgtacacgtg ggcccagcat      600

gagcagcagg tgggtgtgct ggcccgggag ctgggcttca cgcacgtgtc actgtcctcg      660

gaggccatgc ccatggtgcg catcgtccct cgggggcaca cggcctgtgc cgacgcctac      720

ctcacgcccg ccatccagcg ctacgtgcag ggcttctgcc gtggcttcca gggccaactc      780

aaggatgtgc aggtgttgtt catgcgctcc gatggcggcc tggcgcccat ggacaccttc      840

agcggctcca gtgctgtgct ctcgggcccg gccggcggcg tggtgggcta ctcagccacc      900

acctaccagc aggagggtgg ccagcctgtc atcggctttg acatgggagg cacgtccacg      960

gatgtgagcc gctatgctgg ggaattcgag cacgtcttcg aggccagcac agctggcgtc     1020

accctccagg ccccgcagct ggacatcaac accgtggcag cgggaggggg ttcccgcctc     1080

ttcttcaggt ctggcctctt tgtggttggg cccgagtcag caggagccca cccaggaccc     1140

gcctgctacc gcaaaggggg ccctgtgaca gtgacggatg ctaatctggt cctgggtcgc     1200

ctgctgcctg cctccttccc ctgcattttt gggccgggag agaaccaacc actttcccct     1260

gaggcctccc gcaaagccct ggaggctgtg gccactgagg tcaacagctt cctgaccaac     1320

gggccctgcc cggcctcccc gctgagcctg gaggaggtgg ccatggggtt cgtgcgcgtg     1380

gccaacgagg ccatgtgccg gcccatccgt gcactcacgc aggcaagagg ccatgacccc     1440

tcagcccatg tgctggcctg ctttggggga gctggtgggc agcatgcatg tgccatcgcc     1500

cgggccctgg gcatggacac ggtgcacatc cacaggcaca gtgggctgct gtcggccctg     1560

gggctggccc tggctgacgt ggtgcatgag gcacaggaac cctgctccct gctctacgcg     1620

cctgagacct tcgtgcagct ggaccagagg ctgagccgcc tggaggagca gtgtgtggat     1680

gctctgcagg cccagggctt ccccaggtcc cagatcagca ctgagagctt cctgcacctg     1740

cgctaccagg gcacggactg tgctctgatg gtgtctgccc accagcaccc agccacagcc     1800

cgctcgcccc gtgcggggga cttcggggca gcctttgtgg agcggtacat gagggagttt     1860

ggctttgtca tacctgagcg gccggtggtc gtggacgatg tgcgagtgcg gggcaccggc     1920

cgcagtggtc ttcgcctcga ggatgccccc aaagcccaga ccgggcctcc ccgggtggac     1980

aagatgaccc agtgctactt tgaggggggc taccaggaga cccctgtgta cctgctggca     2040

gagctgggct atgggcacaa gctccatggg ccctgcctca tcatcgacag taacagcacc     2100

atcctggtgg agccaggttg ccaggcagag gtgaccaaga caggggacat ctgcatctcc     2160

gtgggggccg aagtccccgg cacagtgggc ccccagctgg accctatcca gctgtccatc     2220

ttctcacacc gcttcatgag cattgctgag cagatgggcc gcatcctgca gcgcacagcc     2280

atctccacca acatcaagga gcgtctggac ttctcctgtg ccctctttgg gcccgatggg     2340

gggctggtgt ccaatgcccc ccacatccct gtgcacctgg gtgccatgca ggagacggtg     2400

cagttccaga ttcagcacct gggggccgat ctccaccctg gcgacgtgct actgagcaac     2460

catcccagtg ccgggggcag ccacctgcca gacctgactg ttatcacacc ggtgttttgg     2520

ccgggtcaga cgcggcctgt gttctatgtg gccagccgag ggcaccacgc agacatcggg     2580

ggcatcacac caggctccat gcccccccac tccaccatgc tgcaacagga gggtgccgtc     2640

tttctgtcct tcaaacttgt ccaggggggc gtcttccagg aggaggcggt gacggaggcc     2700

ctgcgggcgc caggcaaggt ccccaactgc agcggaacca gaaacctgca cgacaacctg     2760

tcggacctcc gtgcccaggt ggcagccaac cagaagggca tccagctggt gggggagctc     2820

attgggcagt acggcctgga cgtggtgcag gcctacatgg gccatattca ggcaaacgct     2880

gagctggccg tgcgagacat gttgcgtgcc tttggaacct cccggcaggc ccggggcctg     2940

cccctggagg tgtcctcgga agaccacatg gacgacggtt cccccatccg cctccgtgtg     3000

cagatcagcc tgagtcaggg cagcgccgtg tttgacttca gcggcactgg gccggaggtg     3060

tttggtaatc tcaacgcacc gcgggccgta accctgtccg ccctcatcta ctgcctgcgc     3120

tgtctggtgg gccgcgacat cccactcaac cagggctgcc tggcgccagt gcgcgtggtc     3180

attccccgag gctccatcct ggacccgtcg cccgaggcgg cggtggtggg cggcaacgtg     3240

ctcacgtcgc agcgcgtggt ggatgtcatc ctgggggcct ttggggcctg cgccgcctcc     3300

cagggctgca tgaacaacgt gaccctgggc aacgcccaca tgggctacta cgagacggtg     3360

gcgggcggcg cgggcgcggg tcccagctgg cacgggcgca gcggtgtgca cagccacatg     3420

accaacacac gcatcaccga ccctgagatc ctggagagcc ggtacccggt catcctgcgc     3480

cgcttcgagc tgcggcgggg ctcggggggc agaggccgct tccgaggcgg cgacggcgtc     3540

acccgcgagc tgctctttcg tgaggaggcg ctgctgtcag tgctgaccga gcgccgcgcc     3600

ttccggccat acgggctcca cgggggcgag cctggcgccc gcggcctaaa cctgctgatc     3660

cgcaaaaacg gccggacggt gaatctgggc ggcaagacgt cggtgaccgt gtaccccggg     3720

gatgtgttct gtctccacac gcccggcggc ggtggctatg gggacccgga ggaccccgcc     3780

ccaccgccgg ggtcgccccc gcaagcactg gcctttcccg agcacggcag cgtctatgag     3840

tatcgccggg cccaggaggc cgtgtga                                         3867


<210>  58
<211>  2565
<212>  DNA
<213>  Homo sapiens;

<400>  58
atggggatgt gttcaaggca agagcgaatt cagaaggata tcgacgtcgt gatccagaag       60

tccagagctg agaaggactg cctgtttgca gatttcagat actctgactc cacctttact      120

tttacctacg ttggcggccc cagaagtgta tcctactcag tacatgtatc tgaagattac      180

ccagataata catatgtgtc aagttcagag aatgatgaag atgtgctagt tactacagag      240

ccaataccag taatttttca tagaatagca acagaattaa gaaaaacaaa tgacattaac      300

tgttgcttat ccataaaatc caaattacaa aaggaaaatg gggaggaatc aagacagaat      360

agtacagtgg aggaagattc tgaaggtgac aatgattccg aagaatttta ttacggaggg      420

caggtgaact atgatgggga actgcacaag cacccacaac tggaagctga tttgtcagca      480

gttagagaga tatatgggcc acatgcagtt tctctcaggg aatatggagc cattgatgat      540

gtagatattg atctgcatat cgatgttagc tttcttgatg aggagattgc tgtggcttgg      600

gaagtaattc gaacagaacc tataattgtt cgactacact gttcacttac acagtattta      660

aatggcccag tgcccactgt tgatgtcttt cagatttcca caaaagagcg atttggattg      720

ggacatcagc tgaaaaaaat catgcagaca tttgttacac agcagtggaa acagagcaaa      780

gaaaaatcca attgcctgca caataaaaag ttgtcagaga agaaagtgaa gtctcccctg      840

catttatttt ctactttgcg caggtcgcca agttatcctc cccctggttg tggcaaaagc      900

aaatccaaac tgaaatctga gcaggacgga atctccaaaa cgcataagct gctgcggagg      960

acttgttcca gcacagtcaa gactgatgat gtgtgtgtca caaagtcaca caggaccttt     1020

ggccgctcct tgtccagcga tcccagggcg gagcaggcta tgacagcaat taaatcgcac     1080

aaacttttga accgtccttg ccctgcagct gttaagtcag aggaatgcct aactctaaag     1140

tcgcatagac tattgactcg atcttgttct ggagatccac gatgtgagca caacacaaac     1200

ttgaagcccc ataaactgtt aagcaggtct tactctagta atctcagaat ggaagaatta     1260

tatggactga aaaatcacaa attgctcagc aagtcctact ccagtgcccc caagtcatcc     1320

aaaactgagc ttttcaagga acctaacgca gagggcagga ggctctctct tacctcaggg     1380

cttattggta tcctaacacc atcttcatct tcatcttctc agcttgctcc aaatggtgca     1440

aaatgcattc cagtacgaga ccgtggcttc ctggtgcaga caattgagtt tgctgaacag     1500

cggatccctg tattaaatga atattgtgtg gtttgtgatg agccacatgt gtttcaaaat     1560

ggccctatgc ttaggcctac cgtatgtgaa cgggagctgt gtgtgtttgc ttttcaaacc     1620

ctgggagtaa tgaatgaagc tgctgatgaa atagcaactg gagctcaggt ggtagatcta     1680

ctagtatcca tgtgtaggtc tgcgttggaa tctcctagaa aagttgtgat tttcgagcca     1740

tatccttctg tggtagatcc taatgatcct cagatgttgg ccttcaaccc caggaaaaag     1800

aactatgatc gagtaatgaa agcactggat agcataactt ctatcagaga aatgacacaa     1860

gcaccatatc tggaaatcaa gaagcaaatg gataaacagg acccccttgc tcatccctta     1920

ctgcaatggg ttatatcaag taatagatca catattgtga aactgccagt taacaggcaa     1980

ttgaagttta tgcatactcc acatcagttc cttcttctca gcagtccacc agccaaagaa     2040

tccaatttta gagctgctaa aaaactcttt ggaagcacct ttgcatttca tggctcacac     2100

attgaaaact ggcactccat cctgaggaat ggtctggttg ttgcttctaa tacacgattg     2160

cagctccatg gtgcaatgta tggaagtgga atctatctta gtccaatgtc aagcatatca     2220

tttggttact cagggatgaa caagaaacag aaggtgtcag ccaaggacga gccagcttca     2280

agcagtaaaa gcagcaatac atcacagtca cagaaaaaag gacagcaatc ccaattcctg     2340

caaagccgta acttaaaatg catagcctta tgtgaagtga tcacctcatc tgacctgcac     2400

aaacatggag agatatgggt tgtccccaat actgaccatg tctgcacacg attctttttc     2460

gtctatgaag acggccaagt gggagatgca aatattaata cacaagaagg aggcattcac     2520

aaagagatcc tccgagtaat tggtaatcaa actgctactg gttaa                     2565


<210>  59
<211>  1248
<212>  DNA
<213>  Homo sapiens;

<400>  59
atgaggggcg cgaacgcctg ggcgccactc tgcctgctgc tggctgccgc cacccagctc       60

tcgcggcagc agtccccaga gagacctgtt ttcacatgtg gtggcattct tactggagag      120

tctggattta ttggcagtga aggttttcct ggagtgtacc ctccaaatag caaatgtact      180

tggaaaatca cagttcccga aggaaaagta gtcgttctca atttccgatt catagacctc      240

gagagtgaca acctgtgccg ctatgacttt gtggatgtgt acaatggcca tgccaatggc      300

cagcgcattg gccgcttctg tggcactttc cggcctggag cccttgtgtc cagtggcaac      360

aagatgatgg tgcagatgat ttctgatgcc aacacagctg gcaatggctt catggccatg      420

ttctccgctg ctgaaccaaa cgaaagaggg gatcagtatt gtggaggact ccttgacaga      480

ccttccggct cttttaaaac ccccaactgg ccagaccggg attaccctgc aggagtcact      540

tgtgtgtggc acattgtagc cccaaagaat cagcttatag aattaaagtt tgagaagttt      600

gatgtggagc gagataacta ctgccgatat gattatgtgg ctgtgtttaa tggcggggaa      660

gtcaacgatg ctagaagaat tggaaagtat tgtggtgata gtccacctgc gccaattgtg      720

tctgagagaa atgaacttct tattcagttt ttatcagact taagtttaac tgcagatggg      780

tttattggtc actacatatt caggccaaaa aaactgccta caactacaga acagcctgtc      840

accaccacat tccctgtaac cacgggttta aaacccaccg tggccttgtg tcaacaaaag      900

tgtagacgga cggggactct ggagggcaat tattgttcaa gtgactttgt attagccggc      960

actgttatca caaccatcac tcgcgatggg agtttgcacg ccacagtctc gatcatcaac     1020

atctacaaag agggaaattt ggcgattcag caggcgggca agaacatgag tgccaggctg     1080

actgtcgtct gcaagcagtg ccctctcctc agaagaggtc taaattacat tattatgggc     1140

caagtaggtg aagatgggcg aggcaaaatc atgccaaaca gctttatcat gatgttcaag     1200

accaagaatc agaagctcct ggatgcctta aaaaataagc aatgttaa                  1248


<210>  60
<211>  1038
<212>  DNA
<213>  Homo sapiens;

<400>  60
atgagcctct tcgggcttct cctgctgaca tctgccctgg ccggccagag acaggggact       60

caggcggaat ccaacctgag tagtaaattc cagttttcca gcaacaagga acagaacgga      120

gtacaagatc ctcagcatga gagaattatt actgtgtcta ctaatggaag tattcacagc      180

ccaaggtttc ctcatactta tccaagaaat acggtcttgg tatggagatt agtagcagta      240

gaggaaaatg tatggataca acttacgttt gatgaaagat ttgggcttga agacccagaa      300

gatgacatat gcaagtatga ttttgtagaa gttgaggaac ccagtgatgg aactatatta      360

gggcgctggt gtggttctgg tactgtacca ggaaaacaga tttctaaagg aaatcaaatt      420

aggataagat ttgtatctga tgaatatttt ccttctgaac cagggttctg catccactac      480

aacattgtca tgccacaatt cacagaagct gtgagtcctt cagtgctacc cccttcagct      540

ttgccactgg acctgcttaa taatgctata actgccttta gtaccttgga agaccttatt      600

cgatatcttg aaccagagag atggcagttg gacttagaag atctatatag gccaacttgg      660

caacttcttg gcaaggcttt tgtttttgga agaaaatcca gagtggtgga tctgaacctt      720

ctaacagagg aggtaagatt atacagctgc acacctcgta acttctcagt gtccataagg      780

gaagaactaa agagaaccga taccattttc tggccaggtt gtctcctggt taaacgctgt      840

ggtgggaact gtgcctgttg tctccacaat tgcaatgaat gtcaatgtgt cccaagcaaa      900

gttactaaaa aataccacga ggtccttcag ttgagaccaa agaccggtgt caggggattg      960

cacaaatcac tcaccgacgt ggccctggag caccatgagg agtgtgactg tgtgtgcaga     1020

gggagcacag gaggatag                                                   1038


<210>  61
<211>  4344
<212>  DNA
<213>  Homo sapiens;

<400>  61
atggctcatt caaagactag gaccaatgat ggaaaaatta catatccgcc tggggtcaag       60

gaaatatcag ataaaatatc taaagaggag atggtgagac gattaaagat ggttgtgaaa      120

acttttatgg atatggacca ggactctgaa gaagaaaagg agctttattt aaacctagct      180

ttacatcttg cttcagattt ttttctcaag catcctgata aagatgttcg cttactggta      240

gcctgctgcc ttgctgatat tttcaggatt tatgctcctg aagctcctta cacatcccct      300

gataaactaa aggatatatt tatgtttata acaagacagt tgaaggggct agaggataca      360

aagagcccac aattcaatag gtatttttat ttacttgaga acattgcttg ggtcaagtca      420

tataacatat gctttgagtt agaagatagc aatgaaattt tcacccagct atacagaacc      480

ttattttcag ttataaacaa tggccacaat cagaaagtcc atatgcacat ggtagacctt      540

atgagctcta ttatttgtga aggtgataca gtgtctcagg agcttttgga tacggtttta      600

gtaaatctgg tacctgctca taagaattta aacaagcaag catatgattt ggcaaaggct      660

ttactgaaga ggacagctca agctattgag ccatatatta ccaatttttt taatcaggtt      720

ctgatgcttg ggaaaacatc tatcagcgat ttgtcagagc atgtctttga cttaattttg      780

gagctctaca atattgatag tcatttgctg ctctctgttt taccccagct tgaatttaaa      840

ttaaagagca atgataatga ggagcgccta caagttgtta aactactggc aaaaatgttt      900

ggggcaaagg attcagaatt ggcttctcaa aacaagccac tttggcagtg ctacttgggc      960

aggtttaatg atatccatgt accaatccgc ctggaatgtg tgaaatttgc tagccattgt     1020

ctcatgaacc atcctgattt agcaaaagac ttaacagagt atcttaaagt gaggtcacat     1080

gaccctgagg aagctattag acatgatgtt attgtgtcaa tagttacagc tgctaaaaag     1140

gatattcttc tggtcaatga tcacttactt aattttgtga gagagagaac attagacaaa     1200

cgatggagag tacgcaaaga agccatgatg ggacttgccc aaatttataa gaaatatgct     1260

ttacagtcag cagctggaaa agatgctgca aaacagatag catggatcaa agacaaattg     1320

ctacatatat attatcaaaa tagtattgat gatcgactac ttgttgaacg gatctttgct     1380

caatacatgg ttcctcacaa tttagaaact acagaacgga tgaaatgctt atattacttg     1440

tatgccacac tggatttaaa tgctgtgaaa gcattgaatg aaatgtggaa atgtcaaaat     1500

ctgctccgac atcaagtaaa ggatttgctt gacttgatta agcaacccaa aacagatgcc     1560

agtgtcaagg ccatattttc aaaagtgatg gttattacaa gaaatttacc tgatcctggt     1620

aaggctcagg atttcatgaa gaaattcaca caggtgttag aagatgatga gaaaataaga     1680

aagcagttag aagtacttgt tagtccaaca tgctcctgca agcaggctga aggttgtgtg     1740

cgtgaaataa ctaagaagtt gggcaacccc aaacagccta caaatccttt cctggaaatg     1800

atcaagtttc tcttggagag gatagcacct gtgcacatag ataccgaatc tatcagtgct     1860

cttattaaac aagtgaacaa atcaatagat ggaacagcag atgatgaaga tgagggtgtt     1920

ccaactgatc aagccatcag agcaggtctt gaactgctta aggtactctc atttacacat     1980

cccatctcat ttcattctgc tgaaacattt gaatcattac tggcttgtct gaaaatggat     2040

gatgaaaaag tagcagaagc tgcactacaa attttcaaaa acacaggaag caaaattgaa     2100

gaggattttc cacacatcag atcagccttg cttcctgttt tacatcacaa atctaaaaaa     2160

ggaccccccc gtcaagccaa atatgccatt cattgtatcc atgcgatatt ttctagtaaa     2220

gagacccagt ttgcacagat atttgagcct ctgcataaga gcctagatcc aagcaacctg     2280

gaacatctca taacaccatt ggttactatt ggtcatattg ctctccttgc acctgatcaa     2340

tttgctgctc ctttgaaatc tttggtagct actttcattg tgaaagatct tctcatgaat     2400

gatcggcttc cagggaaaaa gacaactaaa ctttgggttc cagatgaaga agtatctcct     2460

gagacaatgg tcaaaattca ggctattaaa atgatggttc gatggctact tggaatgaaa     2520

aataatcaca gtaaatcagg aacttctacc ttaagattgc taacaacaat attgcatagt     2580

gatggagact tgacagaaca ggggaaaatt agtaaaccag atatgtcacg tctgagactt     2640

gctgctggga gtgctattgt gaagctggca caagaaccct gttaccatga aatcatcaca     2700

ttagaacaat atcagctatg tgcattagct atcaacgatg aatgctatca agtaagacaa     2760

gtgtttgccc agaaacttca caaaggcctt tcccgtttac ggcttccact tgagtatatg     2820

gcaatctgtg ccctttgtgc aaaagatcct gtaaaggaga gaagagctca tgctaggcaa     2880

tgtttggtga aaaatataaa tgtaaggcgg gagtatctga agcagcatgc agctgttagt     2940

gaaaaattat tgtctcttct accagagtat gttgttccat atacaattca ccttttggca     3000

catgacccag attatgtcaa agtacaggat attgaacaac ttaaagatgt taaagaatgt     3060

ctttggtttg ttctggaaat attaatggct aaaaatgaaa ataacagtca cgcttttatc     3120

agaaagatgg tagaaaatat taaacaaaca aaagatgccc aaggaccaga tgatgcaaaa     3180

atgaatgaaa aactgtacac tgtgtgtgat gttgccatga atatcatcat gtcaaagagt     3240

actacataca gtttggaatc tcctaaagac ccggtactac cagctcgttt cttcactcaa     3300

cctgacaaga atttcagtaa caccaaaaat tatctgcctc ctgaaatgaa atcatttttc     3360

actcctggaa aacctaaaac aaccaatgtt ctaggagctg ttaacaagcc actttcatca     3420

gcaggcaagc aatctcagac caaatcatca cgaatggaaa ctgtaagcaa tgcaagcagc     3480

agctcaaatc caagctctcc tggaagaata aaggggaggc ttgatagttc tgaaatggat     3540

cacagtgaaa atgaagatta cacaatgtct tcacctttgc cggggaaaaa aagtgacaag     3600

agagacgact ctgatcttgt aaggtctgaa ttggagaagc ctagaggcag gaaaaaaacg     3660

cccgtcacag aacaggagga gaaattaggt atggatgact tgactaagtt ggtacaggaa     3720

cagaaaccta aaggcagtca gcgaagtcgg aaaagaggcc atacggcttc agaatctgat     3780

gaacagcagt ggcctgagga aaagaggctc aaagaagata tattagaaaa tgaagatgaa     3840

cagaatagtc cgccaaaaaa gggtaaaaga ggccgaccac caaaacctct tggtggaggt     3900

acaccaaaag aagagccaac aatgaaaact tctaaaaaag gaagcaaaaa aaaatctgga     3960

cctccagcac cagaggagga ggaagaagaa gaaagacaaa gtggaaatac ggaacagaag     4020

tccaaaagca aacagcaccg agtgtcaagg agagcacagc agagagcaga atctcctgaa     4080

tctagtgcaa ttgaatccac acagtccaca ccacagaaag gacgaggaag accatcaaaa     4140

acgccatcac catcacaacc aaaaaaaaat gtccgtgtag gacgctccaa acaagcagct     4200

actaaggaaa atgattcaag tgaagaagta gatgtgtttc agggtagctc tcctgtcgat     4260

gatattccac aggaagaaac agaggaggag gaagtttcta cagtaaatgt acggcggcga     4320

agtgctaaaa gggaacggcg atga                                            4344


<210>  62
<211>  6120
<212>  DNA
<213>  Homo sapiens;

<400>  62
atggatatag ttgatacatt taatcattta attcctactg aacacttaga tgatgcccta       60

tttctaggat ccaacctgga gaatgaagtc tgtgaggatt ttagtgcaag tcaaaatgtc      120

ttagaggact cgctgaagaa catgctcagc gataaggatc ctatgctagg atctgcaagt      180

aaccagttct gtttgcctgt tttggatagc aatgatccca atttccagat gccttgttca      240

acagttgttg gtcttgacga tattatggat gaaggagttg ttaaagaaag tggcaatgat      300

accattgatg aagaagaact gattttacct aacaggaact taagggacaa ggtagaagaa      360

aattcagtga gatctccaag aaaatcacct cgtttaatgg cacaagaaca agtaagaagt      420

ttgcgacaga gcactattgc caagcgttca aatgcagcac cattaagtaa cacaaaaaaa      480

gcatctggga agactgtatc tactgctaaa gcaggagtga aacaaccaga aaggagtcag      540

gttaaagaag aagtatgtat gtcactgaaa cctgagtacc ataaggagaa tagaaggtgc      600

agccgaaata gcggacaaat tgaagtggta cctgaagtat cagtgtcttc aagtcattct      660

tcagtgtcat cttgtcttga aatgaaggat gaagatggat tagattctaa gcataagtgt      720

aataatccgg gagaaataga tgtgccatct catgaattaa attgttcact tctttcagag      780

acttgtgtta ctattggaga aaagaaaaat gaagctttga tggaatgtaa agccaagcct      840

gttggtagtc cattgtttaa gttttcagat aaagaagaac atgaacaaaa tgattccatt      900

tcaggtaaaa cgggtgagac tgttgttgaa gaaatgatag caacaagaaa agttgaacaa      960

gattcaaagg agacagtaaa attatcccat gaagatgacc atattcttga ggacgctgga     1020

tcttctgata tttctagtga tgctgcttgt acaaatccaa ataagacaga aaacagcctt     1080

gtaggtttgc ctagttgtgt agatgaagtg actgaatgta atttggaatt gaaggatacc     1140

atgggtattg ctgataaaac tgagaacacc cttgaaagaa ataaaattga accgttgggt     1200

tattgtgaag atgcggagtc taataggcag ttggagagca ctgagtttaa taaatcaaac     1260

ttagaggtgg ttgatactag tacttttgga ccggaaagta atatcttgga aaatgctatt     1320

tgtgatgtgc ctgaccaaaa ttcaaaacag ttgaatgcta tagaaagtac taaaatagag     1380

tcccatgaaa cagcaaacct tcaggatgac agaaacagcc agtcaagtag cgtttcttac     1440

ttagagtcaa aaagtgtaaa atccaaacat acaaaacctg taattcattc taagcaaaac     1500

atgaccacag atgctccgaa gaaaattgtt gcagcaaagt atgaagtaat acatagcaaa     1560

actaaagtta atgtcaaaag tgtgaaacga aatactgatg taccagaatc tcagcaaaat     1620

tttcataggc cagtcaaagt cagaaaaaaa caaattgata aggagccaaa gattcagagt     1680

tgcaattctg gggttaaatc tgtgaaaaac caagctcatt ctgtactgaa aaaaacatta     1740

caggatcaaa ctttagtaca aattttcaag cccttaactc attctttgag tgataagtca     1800

cacgctcatc ctggttgctt gaaagaacct catcatcctg cacaaactgg acatgtatca     1860

cattctagcc agaaacagtg tcataagcct cagcaacagg ccccagcaat gaaaaccaat     1920

agtcacgtga aggaagagct tgaacaccca ggcgttgagc attttaagga agaggataaa     1980

ctgaaactga aaaaacctga gaagaaccta caaccccgcc aaagaagaag cagcaaaagt     2040

ttttctttag atgagccacc attgttcatt ccagataaca tagctaccat aagaagagaa     2100

ggctctgatc atagctcctc atttgaaagc aaatatatgt ggactcccag caagcagtgt     2160

gggttttgca aaaaaccaca tggcaacagg tttatggttg gctgtgggag atgtgatgac     2220

tggtttcatg gtgattgtgt tgggttaagt ctttctcaag cacagcagat gggcgaggaa     2280

gacaaagaat atgtctgtgt aaaatgttgt gctgaagaag acaaaaagac tgaaatacta     2340

gatccagata ctttggaaaa ccaagctaca gttgaattcc atagtggaga taaaacaatg     2400

gagtgtgaaa agcttggatt atcaaaacac acaacaaatg atagaaccaa atatatagat     2460

gatacagtga agcacaaggt caaaatttta aaacgggagt ctggtgaagg cagaaattca     2520

tcagactgta gagataatga aattaaaaaa tggcagctag ctcctcttcg taagatggga     2580

caaccagttt tacctcggag atcctcagaa gaaaaaagtg aaaaaatacc gaaagagtct     2640

acaactgtta cttgcacagg agaaaaagct tcaaaaccag gtactcatga gaagcaagag     2700

atgaaaaaga agaaagttga aaaaggagtg cttaatgtac atcctgctgc ttctgcttcc     2760

aagccttctg cagatcagat caggcaaagt gtcagacatt ctctcaaaga cattcttatg     2820

aagagactta cagactcaaa tttgaaggta ccagaggaaa aggcagcaaa agttgccaca     2880

aaaattgaga aagagctttt ctcttttttt cgggacacag atgctaaata taagaacaaa     2940

tatagaagtt tgatgtttaa tttgaaagat cctaaaaaca atatattatt taaaaaagta     3000

ctgaaaggag aagtaactcc tgatcatctt atcagaatga gtccagaaga actagcttct     3060

aaagagttag ctgcttggag acgaagagaa aacagacata ccatagaaat gattgagaaa     3120

gagcagagag aagtggaacg acggccaatc accaaaataa ctcataaagg tgaaatagaa     3180

attgagagtg atgccccaat gaaagaacag gaagcagcca tggagattca ggaaccagcc     3240

gccaataagt cattggagaa gccagaagga tctgaaaaac aaaaagagga ggttgactct     3300

atgtctaaag ataccactag tcaacacaga cagcatcttt ttgatctcaa ctgcaaaatc     3360

tgcataggtc gaatggcacc acctgtagat gatctttctc caaaaaaagt aaaagttgtt     3420

gtaggagtag ctcgcaaaca ttcagacaat gaagcagaaa gtatagcaga tgcattatct     3480

tcaacctcaa atattttggc ttctgaattc tttgaggagg agaaacagga gtctccaaag     3540

tcaacgttct ctcctgctcc acgtccagag atgcctggaa ctgttgaagt tgagtctacc     3600

tttctggctc gattgaactt catctggaaa ggttttatca acatgccttc tgtggcaaaa     3660

tttgttacca aagcctatcc agtatctggc tccccagaat acctgacaga ggacctacca     3720

gatagtattc aagtaggtgg caggatatca cctcagacag tttgggatta tgtggaaaaa     3780

ataaaagcat caggaaccaa ggaaatttgt gtggttcgct tcacaccagt aactgaagaa     3840

gatcaaattt cttatacttt gctctttgca tacttcagta gcagaaagcg ctatggagta     3900

gctgctaaca acatgaagca ggttaaagat atgtacctta ttcctttggg tgccacagat     3960

aaaattccac accctcttgt gccttttgat ggacctgggc ttgaactgca tagacctaat     4020

ctattgttgg gcttaattat tcgtcagaaa ctgaagcgac agcacagtgc ctgtgctagt     4080

actagtcata tagctgagac tcctgaaagt gcaccaccaa tagcattgcc acctgataaa     4140

aaaagtaaaa tagaagtttc tacagaagaa gcaccagagg aagaaaatga cttttttaat     4200

tcttttacaa ctgtattaca caagcagaga aataaacctc agcagaatct tcaggaagac     4260

cttccaacag cagttgaacc tttaatggaa gtcaccaaac aggagccacc aaaaccttta     4320

agatttcttc ctggcgtgtt gattggctgg gagaatcaac ctactactct ggaattagca     4380

aataaacctc ttcctgtgga tgatatactt caaagccttt tgggcaccac tggtcaagta     4440

tatgaccagg cccagtcagt gatggaacaa aacactgtta aagaaattcc atttttaaat     4500

gagcagacca actcaaaaat agagaaaaca gataatgtgg aagtaactga tggtgaaaac     4560

aaggagataa aagttaaagt agataatatt tcagaatcta cagataagtc agcagaaata     4620

gaaacatcag tagtagggtc ctcttccatt tctgcagggt ctttgacgag tcttagtctc     4680

agaggtaagc caccagatgt ttctacagaa gcatttttaa caaatttatc aattcagtca     4740

aaacaagagg aaactgtgga gagtaaagag aaaacattaa aaagacagct tcaggaagat     4800

caagagaata atttgcaaga taaccagact tcaaatagtt ctccatgcag atctaatgta     4860

ggaaaaggaa acatagatgg taatgtgagc tgtagtgaaa accttgttgc taatacagcg     4920

aggtctccac agtttatcaa cctgaaaagg gatcctaggc aagcagcagg acgaagtcag     4980

cctgtaacta cttcagaaag caaagatgga gatagttgcc ggaatggaga aaaacacatg     5040

ctgcctggcc tgtcacacaa caaggagcac ttaacagaac aaatcaatgt agaggaaaag     5100

ttgtgttctg cagagaaaaa ctcgtgtgtt cagcagagtg acaatttaaa agttgcacaa     5160

aactcaccat cagtagaaaa catacagact tctcaagcag aacaagcaaa acccttacag     5220

gaggatattt taatgcaaaa tattgaaact gtgcacccat ttcgaagagg atcagcagta     5280

gcgacatctc attttgaagt tggaaacaca tgtccatcag aatttccttc taaaagcatc     5340

acctttactt ccagaagcac cagccccaga acaagtacaa acttttcacc catgaggcca     5400

cagcagccca accttcagca tctcaagtct agcccacctg gatttccatt tccagggcct     5460

cctaattttc ccccacaaag catgtttgga tttccaccac atttgccacc tccattactt     5520

ccccctccag gctttggctt tgctcaaaat cccatggttc cctggccacc tgttgttcat     5580

ctcccaggtc agccacagcg tatgatgggt cctctctcac aagcatcaag gtatataggc     5640

ccgcagaatt tttaccaggt taaagacatt cggaggccag aaaggcgcca tagtgaccct     5700

tggggtaggc aagaccaaca gcaactggat aggccattta ataggggtaa aggggaccgc     5760

cagagatttt atagtgattc acaccatttg aaaagagagc gacatgaaaa ggaatgggag     5820

caagaatctg aaaggcatag acgcagagac agaagccaag acaaggacag agacagaaaa     5880

agcagggagg aagggcacaa agataaagag agggcacggt tatcacatgg tgatcgagga     5940

acagatggaa aagcaagcag agatagtagg aatgtagaca agaagccaga taaacctaaa     6000

agtgaagact atgagaagga caaagaacga gagaaaagta aacacagaga aggagaaaag     6060

gacagggata ggtaccacaa agatagggac cacactgaca gaactaaaag caaaaggtaa     6120


<210>  63
<211>  5061
<212>  DNA
<213>  Homo sapiens;

<400>  63
atggctcaga tatctagcaa cagcggattt aaagaatgtc catcttcaca tccggaacca       60

acaagagcaa aagatgtgga caaagaagaa gcattacaga tggaagcaga ggctttagca      120

aaactgcaaa aggatagaca agtgactgac aatcagagag gctttgagtt gtcaagcagc      180

accagaaaaa aagcacaggt ttataacaag caggattatg atctcatggt gtttcctgaa      240

tcagattccc aaaaaagagc attagatatt gatgtagaaa agctcaccca agctgaactt      300

gagaaactat tgctggatga cagtttcgag actaaaaaaa cacctgtatt accagttact      360

cctattctga gcccttcctt ttcagcacag ctctatttta gacctactat tcagagagga      420

cagtggccac ctggattacc tgggccttcc acttatgctt taccttctat ttatccttct      480

acttacagta aacaggctgc attccaaaat ggcttcaatc caagaatgcc cacttttcca      540

tctacagaac ctatatattt aagtcttccg ggacaatctc catatttctc atatcctttg      600

acacctgcca caccctttca tccacaagga agcttaccta tctatcgtcc agtagtcagt      660

actgacatgg caaaactatt tgacaaaata gctagtacat cagaattttt aaaaaatggg      720

aaagcaagga ctgatttgga gataacagat tcaaaagtca gcaatctaca ggtatctcca      780

aagtctgagg atatcagtaa atttgactgg ttagacttgg atcctctaag taagcctaag      840

gtggataatg tggaggtatt agaccatgag gaagagaaaa atgtttcaag tttgctagca      900

aaggatcctt gggatgctgt tcttcttgaa gagagatcga cagcaaattg tcatcttgaa      960

agaaaggtga atggaaaatc cctttctgtg gcaactgtta caagaagcca gtctttaaat     1020

attcgaacaa ctcagcttgc aaaagcccag ggccatatat ctcagaaaga cccaaatggg     1080

accagtagtt tgccaactgg aagttctctt cttcaagaag ttgaagtaca gaatgaggag     1140

atggcagctt tttgtcgatc cattacaaaa ttgaagacca aatttccata taccaatcac     1200

cgcacaaacc caggctattt gttaagtcca gtcacagcac aaagaaacat atgcggagaa     1260

aatgctagtg tgaaggtctc cattgacatt gaaggatttc agctaccagt tacttttacg     1320

tgtgatgtga gttctactgt agaaatcatt ataatgcaag ccctttgctg ggtacatgat     1380

gacttgaatc aagtagatgt tggcagctat gttctaaaag tttgtggtca agaggaagtg     1440

ctgcagaata atcattgcct tggaagtcat gagcatattc aaaactgtcg aaaatgggac     1500

acagaaatta gactacaact cttgaccttc agtgcaatgt gtcaaaatct ggcccgaaca     1560

gcagaagatg atgaaacacc cgtggattta aacaaacacc tgtatcaaat agaaaaacct     1620

tgcaaagaag ccatgacgag acaccctgtt gaagaactct tagattctta tcacaaccaa     1680

gtagaactgg ctcttcaaat tgaaaaccaa caccgagcag tagatcaagt aattaaagct     1740

gtaagaaaaa tctgtagtgc tttagatggt gtcgagactc ttgccattac agaatcagta     1800

aagaagctaa agagagcagt taatcttcca aggagtaaaa ctgctgatgt gacttctttg     1860

tttggaggag aagacactag caggagttca actaggggct cacttaatcc tgaaaatcct     1920

gttcaagtaa gcataaacca attaactgca gcaatttatg atcttctcag actccatgca     1980

aattctggta ggagtcctac agactgtgcc caaagtagca agagtgtcaa ggaagcatgg     2040

actacaacag agcagctcca gtttactatt tttgctgctc atggaatttc aagtaattgg     2100

gtatcaaatt atgaaaaata ctacttgata tgttcactgt ctcacaatgg aaaggatctt     2160

tttaaaccta ttcaatcaaa gaaggttggc acttacaaga atttcttcta tcttattaaa     2220

tgggatgaac taatcatttt tcctatccag atatcacaat tgccattaga atcagttctt     2280

caccttactc tttttggaat tttaaatcag agcagtggaa gttcccctga ttctaataag     2340

cagagaaagg gaccagaagc tttgggcaaa gtttctttac ctctttttga ctttaaacgg     2400

tttttaacat gtggaactaa acttctatat ctttggactt catcacatac aaattctgtt     2460

cctggaacag ttaccaaaaa aggatatgtc atggaaagaa tagtgctaca ggttgatttt     2520

ccttctcctg catttgatat tatttataca actcctcaag ttgacagaag cattatacag     2580

caacataact tagaaacact agagaatgat ataaaaggga aacttcttga tattcttcat     2640

aaagactcat cacttggact ttctaaagaa gataaagctt ttttatggga gaaacgttat     2700

tattgcttca aacacccaaa ttgtcttcct aaaatattag caagcgcccc aaactggaaa     2760

tgggttaatc ttgccaaaac ttactcattg cttcaccagt ggcctgcatt gtacccacta     2820

attgcattgg aacttcttga ttcaaaattt gctgatcagg aagtaagatc cctagctgtg     2880

acctggattg aggccattag tgatgatgag ctaacagatc ttcttccaca gtttgtacaa     2940

gctttgaaat atgaaattta cttgaatagt tcattagtgc aattcctttt gtccagggca     3000

ttgggaaata tccagatagc acacaattta tattggcttc tcaaagatgc cctgcatgat     3060

gtacagttta gtacccgata cgaacatgtt ttgggtgctc tcctgtcagt aggaggaaaa     3120

cgacttagag aagaacttct aaaacagacg aaacttgtac agcttttagg aggagtagca     3180

gaaaaagtaa ggcaggctag tggatcagcc agacaggttg ttctccaaag aagtatggaa     3240

cgagtacagt ccttttttca gaaaaataaa tgccgtctcc ctctcaagcc aagtctagtg     3300

gcaaaagaat taaatattaa gtcgtgttcc ttcttcagtt ctaatgctgt ccccctaaaa     3360

gtcacaatgg tgaatgctga ccctatggga gaagaaatta atgtcatgtt taaggttggt     3420

gaagatcttc ggcaagatat gttagcttta cagatgataa agattatgga taagatctgg     3480

cttaaagaag gactagatct gaggatggta attttcaaat gtctctcaac tggcagagat     3540

cgaggcatgg tggagctggt tcctgcttcc gataccctca ggaaaatcca agtggaatat     3600

ggtgtgacag gatcctttaa agataaacca cttgcagagt ggctaaggaa atacaatccc     3660

tctgaagaag aatatgaaaa ggcttcagag aactttatct attcctgtgc tggatgctgt     3720

gtagccacct atgttttagg catctgtgat cgacacaatg acaatataat gcttcgaagc     3780

acgggacaca tgtttcacat tgactttgga aagtttttgg gacatgcaca gatgtttggc     3840

agcttcaaaa gggatcgggc tccttttgtg ctgacctctg atatggcata tgtcattaat     3900

gggggtgaaa agcccaccat tcgttttcag ttgtttgtgg acctctgctg tcaggcctac     3960

aacttgataa gaaagcagac aaaccttttt cttaacctcc tttcactgat gattccttca     4020

gggttaccag aacttacaag tattcaagat ttgaaatacg ttagagatgc acttcaaccc     4080

caaactacag acgcagaagc tacaattttc tttactaggc ttattgaatc aagtttggga     4140

agcattgcca caaagtttaa cttcttcatt cacaaccttg ctcagcttcg tttttctggt     4200

cttccttcta atgatgagcc catcctttca ttttcaccta aaacatactc ctttagacaa     4260

gatggtcgaa tcaaggaagt ctctgttttt acatatcata agaaatacaa cccagataaa     4320

cattatattt atgtagtccg aattttgagg gaaggacaga ttgaaccatc atttgtcttc     4380

cgaacatttg acgaatttca ggaacttcac aataagctca gtattatttt tccactttgg     4440

aagttaccag gctttcctaa taggatggtt ctaggaagaa cacacataaa agatgtagca     4500

gccaaaagga aaattgagtt aaacagttac ttacagagtt tgatgaatgc ttcaacggat     4560

gtagcagagt gtgatcttgt ttgtactttc ttccaccctt tacttcgtga tgagaaagct     4620

gaagggatag ctaggtctgc agatgcaggt tccttcagtc ctactccagg ccaaatagga     4680

ggagctgtga aattatccat ctcttaccga aatggtactc ttttcatcat ggtgatgcat     4740

atcaaagatc ttgttactga agatggagct gacccaaatc catatgtcaa aacataccta     4800

cttccagata accacaaaac atccaaacgt aaaaccaaaa tttcacgaaa aacgaggaat     4860

ccgacattca atgaaatgct tgtatacagt ggatatagca aagaaaccct aagacagcga     4920

gaacttcaac taagtgtact cagtgcagaa tctctgcggg agaatttttt cttgggtgga     4980

gtaaccctgc ctttgaaaga tttcaacttg agcaaagaga cggttaaatg gtatcagctg     5040

actgcggcaa catacttgta a                                               5061


<210>  64
<211>  1326
<212>  DNA
<213>  Homo sapiens;

<400>  64
atggtgccac ccaaattgca tgtgcttttc tgcctctgcg gctgcctggc tgtggtttat       60

ccttttgact ggcaatacat aaatcctgtt gcccatatga aatcatcagc atgggtcaac      120

aaaatacaag tactgatggc tgctgcaagc tttggccaaa ctaaaatccc ccggggaaat      180

gggccttatt ccgttggttg tacagactta atgtttgatc acactaataa gggcaccttc      240

ttgcgtttat attatccatc ccaagataat gatcgccttg acaccctttg gatcccaaat      300

aaagaatatt tttggggtct tagcaaattt cttggaacac actggcttat gggcaacatt      360

ttgaggttac tctttggttc aatgacaact cctgcaaact ggaattcccc tctgaggcct      420

ggtgaaaaat atccacttgt tgttttttct catggtcttg gggcattcag gacactttat      480

tctgctattg gcattgacct ggcatctcat gggtttatag ttgctgctgt agaacacaga      540

gatagatctg catctgcaac ttactatttc aaggaccaat ctgctgcaga aataggggac      600

aagtcttggc tctaccttag aaccctgaaa caagaggagg agacacatat acgaaatgag      660

caggtacggc aaagagcaaa agaatgttcc caagctctca gtctgattct tgacattgat      720

catggaaagc cagtgaagaa tgcattagat ttaaagtttg atatggaaca actgaaggac      780

tctattgata gggaaaaaat agcagtaatt ggacattctt ttggtggagc aacggttatt      840

cagactctta gtgaagatca gagattcaga tgtggtattg ccctggatgc atggatgttt      900

ccactgggtg atgaagtata ttccagaatt cctcagcccc tcttttttat caactctgaa      960

tatttccaat atcctgctaa tatcataaaa atgaaaaaat gctactcacc tgataaagaa     1020

agaaagatga ttacaatcag gggttcagtc caccagaatt ttgctgactt cacttttgca     1080

actggcaaaa taattggaca catgctcaaa ttaaagggag acatagattc aaatgtagct     1140

attgatctta gcaacaaagc ttcattagca ttcttacaaa agcatttagg acttcataaa     1200

gattttgatc agtgggactg cttgattgaa ggagatgatg agaatcttat tccagggacc     1260

aacattaaca caaccaatca acacatcatg ttacagaact cttcaggaat agagaaatac     1320

aattag                                                                1326


<210>  65
<211>  4233
<212>  DNA
<213>  Homo sapiens;

<400>  65
atggcggaca ccgacctgtt catggaatgt gaggaggagg agttggagcc atggcagaaa       60

atcagtgatg tcattgagga ctctgtagtt gaagattata attcagtgga taaaactacc      120

acagtttctg tgagccagca gccagtctcg gctccagtgc ccatcgctgc ccatgcttct      180

gttgctgggc acctctctac atccaccacc gttagtagca gcggggcaca gaacagcgac      240

agtacaaaga agactcttgt cacactaatt gccaacaaca atgctggcaa tcctttggtc      300

cagcaaggtg gacagccact catcctgacc cagaatccag ccccaggtct gggcacaatg      360

gttactcaac cagtattgag gcctgttcag gtcatgcaga atgccaatca tgtgactagt      420

tcccctgtgg cctcacaacc aatatttatc actacgcagg gatttcctgt aaggaatgtc      480

cggcctgtac aaaatgcaat gaatcaggtt gggattgtgc tgaacgtaca gcaaggccaa      540

acggttagac caattacact agttccagcc ccaggtaccc agtttgttaa gccgacagtt      600

ggagttccac aagtgttctc ccagatgacc cctgtgaggc caggctccac aatgcctgtg      660

aggcccacca ccaacacctt caccaccgtc atcccggcca ctcttaccat tcgaagcacc      720

gtcccacagt cccagtccca gcagaccaag tccactccca gcacttctac cactcccact      780

gccacacagc caacctcact ggggcaacta gctgttcagt ctccaggcca gtcaaaccag      840

accacgaatc ccaagctagc tccctccttc ccctctccac ctgcagtgag cattgccagc      900

tttgtcactg tgaagcgacc tggtgttaca ggcgaaaata gcaatgaagt ggccaaattg      960

gtgaataccc ttaacaccat cccttccctg ggccagagtc ctgggccagt ggtggtgtcc     1020

aacaacagct ctgctcatgg ctctcaaaga accagcggac ctgagtcttc aatgaaagtg     1080

acctcttcca tcccagtatt tgacctccag gatggtggac ggaaaatatg tccacgatgt     1140

aatgctcaat ttcgtgttac tgaagctttg agaggtcaca tgtgttactg ttgcccagaa     1200

atggttgaat accagaagaa aggaaagtcc ctggattcag aacccagtgt cccatcagca     1260

gcaaagcccc catcccctga gaaaacagct cctgttgctt ccacaccctc ttctacacct     1320

attcctgctc tgtcaccgcc taccaaagta ccagaaccaa atgagaacgt gggcgatgcc     1380

gtccagacca aactcattat gcttgtagat gacttctact atggacggga tggtggcaaa     1440

gtagcccagc tcacaaattt ccctaaggtc gccacatctt tccgatgccc acattgtacc     1500

aaaaggctaa aaaacaatat tcgattcatg aaccatatga aacaccacgt agaactcgat     1560

cagcagaacg gtgaggtaga tggtcacact atctgccagc actgttaccg ccagttttcc     1620

actcccttcc agcttcagtg ccacttggaa aatgttcata gtccctatga atctactacc     1680

aagtgcaaga tctgtgaatg ggcgtttgaa agtgagccac tatttctcca gcatatgaag     1740

gatactcata agcctggaga gatgccttat gtttgccagg tgtgtcaata tcgctcctca     1800

ctctactctg aggtagatgt ccattttcgg atgatccatg aggatacccg gcatctgctc     1860

tgcccttatt gcctgaaggt cttcaaaaat ggcaatgcat tccaacagca ttacatgagg     1920

caccagaaga gaaatgttta tcactgcaac aaatgccggc tgcagtttct ctttgccaag     1980

gacaaaattg aacacaagct tcaacaccat aaaaccttcc gtaaacccaa gcagctggag     2040

ggcttgaaac caggcaccaa ggtgacaatc cgggcttccc gagggcagcc acgaactgtt     2100

cctgtatcct ctaatgatac acctcccagc gccttgcagg aggcagcacc gctgacctcc     2160

tcaatggacc ctctgcctgt cttcctttat ccccctgtcc agcgcagcat ccagaagaga     2220

gctgttagga aaatgagtgt catgggccgg cagacatgcc tggagtgcag cttcgagatc     2280

ccagacttcc ctaatcattt ccctacttac gtacactgct ctctgtgtcg ctatagcacc     2340

tgctgttctc gagcttatgc caaccacatg atcaacaatc atgttccacg gaagagcccc     2400

aagtatttgg ctttgtttaa aaattctgtg agtggaatca agctggcctg cacttcatgt     2460

acctttgtta cctctgtggg cgatgctatg gccaagcatt tggtattcaa cccctctcac     2520

agatccagca gcatcctgcc acggggactc acttggatag ctcactcaag gcatggccag     2580

actcgtgacc gagtgcatga ccggaacgtg aagaatatgt accctcctcc ttccttcccc     2640

actaacaaag ctgccactgt gaaatctgcg ggggccaccc cagctgagcc tgaagagcta     2700

ctaactccct tagccccagc actcccatca ccagcctcaa ctgcaacccc accaccaacc     2760

cccactcacc cgcaggcttt agcccttcca ccgctggcta cagagggagc cgaatgtctg     2820

aatgttgatg atcaggatga agggagccca gtcacccaag aacctgagct agcatcaggt     2880

ggtggtggta gtggtggagt tggcaaaaag gagcagctgt ctgtgaagaa gcttcgagta     2940

gtactgtttg ctctatgctg caatacagaa caggcagctg aacacttccg aaatccccag     3000

cgacgtattc gccgttggct tcgacgtttc caggcctccc agggggagaa tctagagggc     3060

aaatatctga gctttgaggc agaagagaaa ctggctgagt gggtgctaac ccagcgcgaa     3120

caacagctac ctgtaaatga ggagaccttg ttccagaagg ccaccaaaat aggacgttct     3180

ttggaagggg ggtttaagat ctcctatgag tgggctgtgc gtttcatgct gcggcaccac     3240

ctgactcccc atgcccggcg agctgtggcc cacaccctac ctaaggatgt agcagagaat     3300

gcaggactct tcattgattt tgtacaacgg cagattcaca accaggactt acccttgtct     3360

atgattgtgg ctattgatga gatctctttg ttcctggata cagaggtgct gagcagtgat     3420

gatcgaaagg agaatgccct gcagacagtg ggcacagggg aaccttggtg tgatgtagtc     3480

ctagccattc tggcagatgg cactgtcctt cccaccctgg ttttctacag agggcagatg     3540

gatcagcctg ctaacatgcc agactccata ttgctagagg caaaggagag tggctacagt     3600

gatgacgaga tcatggagct gtggtcaact cgagtgtggc agaagcacac agcttgccag     3660

cgcagcaaag gcatgcttgt gatggactgt catcgcactc acttgtcaga agaggtactg     3720

gctatgctta gtgcctctag cactttgcct gcagtggtcc cagcaggctg tagctccaaa     3780

attcagccat tagatgtatg catcaaaaga actgtcaaga acttcctgca taaaaaatgg     3840

aaggaacagg ctcgggaaat ggcagatact gcatgtgatt ctgatgtcct gcttcagctg     3900

gtgcttgtct ggctgggtga agtgctaggt gtcattgggg actgtccaga gctagttcag     3960

cgctccttcc tggtggctag tgttctgcct ggccccgatg gcaacattaa ctcacctaca     4020

agaaatgctg acatgcagga ggagctaatt gcctccctag aggagcaact gaagctgagt     4080

ggggaacatt ctgagtcttc cactccacga cccagatcat ctcctgaaga gacaattgag     4140

cctgaaagtc ttcaccagct ctttgagggt gaaagtgaga ccgagtcttt ctatggcttt     4200

gaagaagctg acctagatct gatggagatt tga                                  4233


<210>  66
<211>  2637
<212>  DNA
<213>  Homo sapiens;

<400>  66
atggccaccg ccccctctta tcccgccggg ctccctggct ctcccgggcc ggggtctcct       60

ccgccccccg gcggcctaga gctgcagtcg ccgccaccgc tactgcccca gatcccggcc      120

ccgggttccg gggtctcctt tcacatccag atcgggctga cccgcgagtt cgtgctgttg      180

cccgccgcct ccgagctggc tcatgtgaag cagctggcct gttccatcgt ggaccagaag      240

ttccctgagt gtggcttcta cggcctttac gacaagatcc tgcttttcaa acatgacccc      300

acgtcggcca acctcctgca gctggtgcgc tcgtccggag acatccagga gggcgacctg      360

gtggaggtgg tgctgtcggc ctcggccacc ttcgaggact tccagatccg cccgcacgcc      420

ctcacggtgc actcctatcg ggcgcctgcc ttctgtgatc actgcgggga gatgctcttc      480

ggcctagtgc gccagggcct caagtgcgat ggctgcgggc tgaactacca caagcgctgt      540

gccttcagca tccccaacaa ctgtagtggg gcccgcaaac ggcgcctgtc atccacgtct      600

ctggccagtg gccactcggt gcgcctcggc acctccgagt ccctgccctg cacggctgaa      660

gagctgagcc gtagcaccac cgaactcctg cctcgccgtc ccccgtcatc ctcttcctcc      720

tcttctgcct catcgtatac gggccgcccc attgagctgg acaagatgct gctctccaag      780

gtcaaggtgc cgcacacctt cctcatccac agctatacac ggcccaccgt ttgccaggct      840

tgcaagaaac tcctcaaggg cctcttccgg cagggcctgc aatgcaaaga ctgcaagttt      900

aactgtcaca aacgctgcgc cacccgcgtc cctaatgact gcctggggga ggcccttatc      960

aatggagatg tgccgatgga ggaggccacc gatttcagcg aggctgacaa gagcgccctc     1020

atggatgagt cagaggactc cggtgtcatc cctggctccc actcagagaa tgcgctccac     1080

gccagtgagg aggaggaagg cgagggaggc aaggcccaga gctccctggg gtacatcccc     1140

ctaatgaggg tggtgcaatc ggtgcgacac acgacgcgga aatccagcac cacgctgcgg     1200

gagggttggg tggttcatta cagcaacaag gacacgctga gaaagcggca ctattggcgc     1260

ctggactgca agtgtatcac gctcttccag aacaacacga ccaacagata ctataaggaa     1320

attccgctgt cagaaatcct cacggtggag tccgcccaga acttcagcct tgtgccgccg     1380

ggcaccaacc cacactgctt tgagatcgtc actgccaatg ccacctactt cgtgggcgag     1440

atgcctggcg ggactccggg tgggccaagt gggcaggggg ctgaggccgc ccggggctgg     1500

gagacagcca tccgccaggc cctgatgccc gtcatccttc aggacgcacc cagcgcccca     1560

ggccacgcgc cccacagaca agcttctctg agcatctctg tgtccaacag tcagatccaa     1620

gagaatgtgg acattgccac tgtctaccag atcttccctg acgaagtgct gggctcaggg     1680

cagtttggag tggtctatgg aggaaaacac cggaagacag gccgggacgt ggcagttaag     1740

gtcattgaca aactgcgctt ccctaccaag caggagagcc agctccggaa tgaagtggcc     1800

attctgcaga gcctgcggca tcccgggatc gtgaacctgg agtgcatgtt cgagacgcct     1860

gagaaagtgt ttgtggtgat ggagaagctg catggggaca tgttggagat gatcctgtcc     1920

agtgagaagg gccggctgcc tgagcgcctc accaagttcc tcatcaccca gatcctggtg     1980

gctttgagac accttcactt caagaacatt gtccactgtg acttgaaacc agaaaacgtg     2040

ttgctggcat cagcagaccc atttcctcag gtgaagctgt gtgactttgg ctttgctcgc     2100

atcatcggcg agaagtcgtt ccgccgctca gtggtgggca cgccggccta cctggcaccc     2160

gaggtgctgc tcaaccaggg ctacaaccgc tcgctggaca tgtggtcagt gggcgtgatc     2220

atgtacgtca gcctcagcgg caccttccct ttcaacgagg atgaggacat caatgaccag     2280

atccagaacg ccgccttcat gtacccggcc agcccctgga gccacatctc agctggagcc     2340

attgacctca tcaacaacct gctgcaggtg aagatgcgca aacgctacag cgtggacaaa     2400

tctctcagcc acccctggtt acaggagtac cagacgtggc tggacctccg agagctggag     2460

gggaagatgg gagagcgata catcacgcat gagagtgacg acgcgcgctg ggagcagttt     2520

gcagcagagc atccgctgcc tgggtctggg ctgcccacgg acagggatct cggtggggcc     2580

tgtccaccac aggaccacga catgcagggg ctggcggagc gcatcagtgt tctctga        2637


<210>  67
<211>  12387
<212>  DNA
<213>  Homo sapiens;

<400>  67
atggcgggct ccggagccgg tgtgcgttgc tccctgctgc ggctgcagga gaccttgtcc       60

gctgcggacc gctgcggtgc tgccctggcc ggtcatcaac tgatccgcgg cctggggcag      120

gaatgcgtcc tgagcagcag ccccgcggtg ctggcattac agacatcttt agttttttcc      180

agagatttcg gtttgcttgt atttgtccgg aagtcactca acagtattga atttcgtgaa      240

tgtagagaag aaatcctaaa gtttttatgt attttcttag aaaaaatggg ccagaagatc      300

gcaccttact ctgttgaaat taagaacact tgtaccagtg tttatacaaa agatagagct      360

gctaaatgta aaattccagc cctggacctt cttattaagt tacttcagac ttttagaagt      420

tctagactca tggatgaatt taaaattgga gaattattta gtaaattcta tggagaactt      480

gcattgaaaa aaaaaatacc agatacagtt ttagaaaaag tatatgagct cctaggatta      540

ttgggtgaag ttcatcctag tgagatgata aataatgcag aaaacctgtt ccgcgctttt      600

ctgggtgaac ttaagaccca gatgacatca gcagtaagag agcccaaact acctgttctg      660

gcaggatgtc tgaaggggtt gtcctcactt ctgtgcaact tcactaagtc catggaagaa      720

gatccccaga cttcaaggga gatttttaat tttgtactaa aggcaattcg tcctcagatt      780

gatctgaaga gatatgctgt gccctcagct ggcttgcgcc tatttgccct gcatgcatct      840

cagtttagca cctgccttct ggacaactac gtgtctctat ttgaagtctt gttaaagtgg      900

tgtgcccaca caaatgtaga attgaaaaaa gctgcacttt cagccctgga atcctttctg      960

aaacaggttt ctaatatggt ggcgaaaaat gcagaaatgc ataaaaataa actgcagtac     1020

tttatggagc agttttatgg aatcatcaga aatgtggatt cgaacaacaa ggagttatct     1080

attgctatcc gtggatatgg actttttgca ggaccgtgca aggttataaa cgcaaaagat     1140

gttgacttca tgtacgttga gctcattcag cgctgcaagc agatgttcct cacccagaca     1200

gacactggtg acgaccgtgt ttatcagatg ccaagcttcc tccagtctgt tgcaagcgtc     1260

ttgctgtacc ttgacacagt tcctgaggtg tatactccag ttctggagca cctcgtggtg     1320

atgcagatag acagtttccc acagtacagt ccaaaaatgc agctggtgtg ttgcagagcc     1380

atagtgaagg tgttcctagc tttggcagca aaagggccag ttctcaggaa ttgcattagt     1440

actgtggtgc atcagggttt aatcagaata tgttctaaac cagtggtcct tccaaagggc     1500

cctgagtctg aatctgaaga ccaccgtgct tcaggggaag tcagaactgg caaatggaag     1560

gtgcccacat acaaagacta cgtggatctc ttcagacatc tcctgagctc tgaccagatg     1620

atggattcta ttttagcaga tgaagcattt ttctctgtga attcctccag tgaaagtctg     1680

aatcatttac tttatgatga atttgtaaaa tccgttttga agattgttga gaaattggat     1740

cttacacttg aaatacagac tgttggggaa caagagaatg gagatgaggc gcctggtgtt     1800

tggatgatcc caacttcaga tccagcggct aacttgcatc cagctaaacc taaagatttt     1860

tcggctttca ttaacctggt ggaattttgc agagagattc tccctgagaa acaagcagaa     1920

ttttttgaac catgggtgta ctcattttca tatgaattaa ttttgcaatc tacaaggttg     1980

cccctcatca gtggtttcta caaattgctt tctattacag taagaaatgc caagaaaata     2040

aaatatttcg agggagttag tccaaagagt ctgaaacact ctcctgaaga cccagaaaag     2100

tattcttgct ttgctttatt tgtgaaattt ggcaaagagg tggcagttaa aatgaagcag     2160

tacaaagatg aacttttggc ctcttgtttg acctttcttc tgtccttgcc acacaacatc     2220

attgaactcg atgttagagc ctacgttcct gcactgcaga tggctttcaa actgggcctg     2280

agctataccc ccttggcaga agtaggcctg aatgctctag aagaatggtc aatttatatt     2340

gacagacatg taatgcagcc ttattacaaa gacattctcc cctgcctgga tggatacctg     2400

aagacttcag ccttgtcaga tgagaccaag aataactggg aagtgtcagc tctttctcgg     2460

gctgcccaga aaggatttaa taaagtggtg ttaaagcatc tgaagaagac aaagaacctt     2520

tcatcaaacg aagcaatatc cttagaagaa ataagaatta gagtagtaca aatgcttgga     2580

tctctaggag gacaaataaa caaaaatctt ctgacagtca cgtcctcaga tgagatgatg     2640

aagagctatg tggcctggga cagagagaag cggctgagct ttgcagtgcc ctttagagag     2700

atgaaacctg tcattttcct ggatgtgttc ctgcctcgag tcacagaatt agcgctcaca     2760

gccagtgaca gacaaactaa agttgcagcc tgtgaacttt tacatagcat ggttatgttt     2820

atgttgggca aagccacgca gatgccagaa gggggacagg gagccccacc catgtaccag     2880

ctctataagc ggacgtttcc tgtgctgctt cgacttgcgt gtgatgttga tcaggtgaca     2940

aggcaactgt atgagccact agttatgcag ctgattcact ggttcactaa caacaagaaa     3000

tttgaaagtc aggatactgt tgccttacta gaagctatat tggatggaat tgtggaccct     3060

gttgacagta ctttaagaga tttttgtggt cggtgtattc gagaattcct taaatggtcc     3120

attaagcaaa taacaccaca gcagcaggag aagagtccag taaacaccaa atcgcttttc     3180

aagcgacttt atagccttgc gcttcacccc aatgctttca agaggctggg agcatcactt     3240

gcctttaata atatctacag ggaattcagg gaagaagagt ctctggtgga acagtttgtg     3300

tttgaagcct tggtgatata catggagagt ctggccttag cacatgcaga tgagaagtcc     3360

ttaggtacaa ttcaacagtg ttgtgatgcc attgatcacc tatgccgcat cattgaaaag     3420

aagcatgttt ctttaaataa agcaaagaaa cgacgtttgc cgcgaggatt tccaccttcc     3480

gcatcattgt gtttattgga tctggtcaag tggcttttag ctcattgtgg gaggccccag     3540

acagaatgtc gacacaaatc cattgaactc ttttataaat tcgttccttt attgccaggc     3600

aacagatccc ctaatttgtg gctgaaagat gttctcaagg aagaaggtgt ctcttttctc     3660

atcaacacct ttgagggggg tggctgtggc cagccctcgg gcatcctggc ccagcccacc     3720

ctcttgtacc ttcgggggcc attcagcctg caggccacgc tatgctggct ggacctgctc     3780

ctggccgcgt tggagtgcta caacacgttc attggcgaga gaactgtagg agcgctccag     3840

gtcctaggta ctgaagccca gtcttcactt ttgaaagcag tggctttctt cttagaaagc     3900

attgccatgc atgacattat agcagcagaa aagtgctttg gcactggggc agcaggtaac     3960

agaacaagcc cacaagaggg agaaaggtac aactacagca aatgcaccgt tgtggtccgg     4020

attatggagt ttaccacgac tctgctaaac acctccccgg aaggatggaa gctcctgaag     4080

aaggacttgt gtaatacaca cctgatgaga gtcctggtgc agacgctgtg tgagcccgca     4140

agcataggtt tcaacatcgg agacgtccag gttatggctc atcttcctga tgtttgtgtg     4200

aatctgatga aagctctaaa gatgtcccca tacaaagata tcctagagac ccatctgaga     4260

gagaaaataa cagcacagag cattgaggag ctttgtgccg tcaacttgta tggccctgac     4320

gcgcaagtgg acaggagcag gctggctgct gttgtgtctg cctgtaaaca gcttcacaga     4380

gctgggcttc tgcataatat attaccgtct cagtccacag atttgcatca ttctgttggc     4440

acagaacttc tttccctggt ttataaaggc attgcccctg gagatgagag acagtgtctg     4500

ccttctctag acctcagttg taagcagctg gccagcggac ttctggagtt agcctttgct     4560

tttggaggac tgtgtgagcg ccttgtgagt cttctcctga acccagcggt gctgtccacg     4620

gcgtccttgg gcagctcaca gggcagcgtc atccacttct cccatgggga gtatttctat     4680

agcttgttct cagaaacgat caacacggaa ttattgaaaa atctggatct tgctgtattg     4740

gagctcatgc agtcttcagt ggataatacc aaaatggtga gtgccgtttt gaacggcatg     4800

ttagaccaga gcttcaggga gcgagcaaac cagaaacacc aaggactgaa acttgcgact     4860

acaattctgc aacactggaa gaagtgtgat tcatggtggg ccaaagattc ccctctcgaa     4920

actaaaatgg cagtgctggc cttactggca aaaattttac agattgattc atctgtatct     4980

tttaatacaa gtcatggttc attccctgaa gtctttacaa catatattag tctacttgct     5040

gacacaaagc tggatctaca tttaaagggc caagctgtca ctcttcttcc attcttcacc     5100

agcctcactg gaggcagtct ggaggaactt agacgtgttc tggagcagct catcgttgct     5160

cacttcccca tgcagtccag ggaatttcct ccaggaactc cgcggttcaa taattatgtg     5220

gactgcatga aaaagtttct agatgcattg gaattatctc aaagccctat gttgttggaa     5280

ttgatgacag aagttctttg tcgggaacag cagcatgtca tggaagaatt atttcaatcc     5340

agtttcagga ggattgccag aaggggttca tgtgtcacac aagtaggcct tctggaaagc     5400

gtgtatgaaa tgttcaggaa ggatgacccc cgcctaagtt tcacacgcca gtcctttgtg     5460

gaccgctccc tcctcactct gctgtggcac tgtagcctgg atgctttgag agaattcttc     5520

agcacaattg tggtggatgc cattgatgtg ttgaagtcca ggtttacaaa gctaaatgaa     5580

tctacctttg atactcaaat caccaagaag atgggctact ataagattct agacgtgatg     5640

tattctcgcc ttcccaaaga tgatgttcat gctaaggaat caaaaattaa tcaagttttc     5700

catggctcgt gtattacaga aggaaatgaa cttacaaaga cattgattaa attgtgctac     5760

gatgcattta cagagaacat ggcaggagag aatcagctgc tggagaggag aagactttac     5820

cattgtgcag catacaactg cgccatatct gtcatctgct gtgtcttcaa tgagttaaaa     5880

ttttaccaag gttttctgtt tagtgaaaaa ccagaaaaga acttgcttat ttttgaaaat     5940

ctgatcgacc tgaagcgccg ctataatttt cctgtagaag ttgaggttcc tatggaaaga     6000

aagaaaaagt acattgaaat taggaaagaa gccagagaag cagcaaatgg ggattcagat     6060

ggtccttcct atatgtcttc cctgtcatat ttggcagaca gtaccctgag tgaggaaatg     6120

agtcaatttg atttctcaac cggagttcag agctattcat acagctccca agaccctaga     6180

cctgccactg gtcgttttcg gagacgggag cagcgggacc ccacggtgca tgatgatgtg     6240

ctggagctgg agatggacga gctcaatcgg catgagtgca tggcgcccct gacggccctg     6300

gtcaagcaca tgcacagaag cctgggcccg cctcaaggag aagaggattc agtgccaaga     6360

gatcttcctt cttggatgaa attcctccat ggcaaactgg gaaatccaat agtaccatta     6420

aatatccgtc tcttcttagc caagcttgtt attaatacag aagaggtctt tcgcccttac     6480

gcgaagcact ggcttagccc cttgctgcag ctggctgctt ctgaaaacaa tggaggagaa     6540

ggaattcact acatggtggt tgagatagtg gccactattc tttcatggac aggcttggcc     6600

actccaacag gggtccctaa agatgaagtg ttagcaaatc gattgcttaa tttcctaatg     6660

aaacatgtct ttcatccaaa aagagctgtg tttagacaca accttgaaat tataaagacc     6720

cttgtcgagt gctggaagga ttgtttatcc atcccttata ggttaatatt tgaaaagttt     6780

tccggtaaag atcctaattc taaagacaac tcagtaggga ttcaattgct aggcatcgtg     6840

atggccaatg acctgcctcc ctatgaccca cagtgtggca tccagagtag cgaatacttc     6900

caggctttgg tgaataatat gtcctttgta agatataaag aagtgtatgc cgctgcagca     6960

gaagttctag gacttatact tcgatatgtt atggagagaa aaaacatact ggaggagtct     7020

ctgtgtgaac tggttgcgaa acaattgaag caacatcaga atactatgga ggacaagttt     7080

attgtgtgct tgaacaaagt gaccaagagc ttccctcctc ttgcagacag gttcatgaat     7140

gctgtgttct ttctgctgcc aaaatttcat ggagtgttga aaacactctg tctggaggtg     7200

gtactttgtc gtgtggaggg aatgacagag ctgtacttcc agttaaagag caaggacttc     7260

gttcaagtca tgagacatag agatgatgaa agacaaaaag tatgtttgga cataatttat     7320

aagatgatgc caaagttaaa accagtagaa ctccgagaac ttctgaaccc cgttgtggaa     7380

ttcgtttccc atccttctac aacatgtagg gaacaaatgt ataatattct catgtggatt     7440

catgataatt acagagatcc agaaagtgag acagataatg actcccagga aatatttaag     7500

ttggcaaaag atgtgctgat tcaaggattg atcgatgaga accctggact tcaattaatt     7560

attcgaaatt tctggagcca tgaaactagg ttaccttcaa ataccttgga ccggttgctg     7620

gcactaaatt ccttatattc tcctaagata gaagtgcact ttttaagttt agcaacaaat     7680

tttctgctcg aaatgaccag catgagccca gattatccaa accccatgtt cgagcatcct     7740

ctgtcagaat gcgaatttca ggaatatacc attgattctg attggcgttt ccgaagtact     7800

gttctcactc cgatgtttgt ggagacccag gcctcccagg gcactctcca gacccgtacc     7860

caggaagggt ccctctcagc tcgctggcca gtggcagggc agataagggc cacccagcag     7920

cagcatgact tcacactgac acagactgca gatggaagaa gctcatttga ttggctgacc     7980

gggagcagca ctgacccgct ggtcgaccac accagtccct catctgactc cttgctgttt     8040

gcccacaaga ggagtgaaag gttacagaga gcacccttga agtcagtggg gcctgatttt     8100

gggaaaaaaa ggctgggcct tccaggggac gaggtggata acaaagtgaa aggtgcggcc     8160

ggccggacgg acctactacg actgcgcaga cggtttatga gggaccagga gaagctcagt     8220

ttgatgtatg ccagaaaagg cgttgctgag caaaaacgag agaaggaaat caagagtgag     8280

ttaaaaatga agcaggatgc ccaggtcgtt ctgtacagaa gctaccggca cggagacctt     8340

cctgacattc agatcaagca cagcagcctc atcaccccgt tacaggccgt ggcccagagg     8400

gacccaataa ttgcaaaaca gctctttagc agcttgtttt ctggaatttt gaaagagatg     8460

gataaattta agacactgtc tgaaaaaaac aacatcactc aaaagttgct tcaagacttc     8520

aatcgttttc ttaataccac cttctctttc tttccaccct ttgtctcttg tattcaggac     8580

attagctgtc agcacgcagc cctgctgagc ctcgacccag cggctgttag cgctggttgc     8640

ctggccagcc tacagcagcc cgtgggcatc cgcctgctag aggaggctct gctccgcctg     8700

ctgcctgctg agctgcctgc caagcgagtc cgtgggaagg cccgcctccc tcctgatgtc     8760

ctcagatggg tggagcttgc taagctgtat agatcaattg gagaatacga cgtcctccgt     8820

gggattttta ccagtgagat aggaacaaag caaatcactc agagtgcatt attagcagaa     8880

gccagaagtg attattctga agctgctaag cagtatgatg aggctctcaa taaacaagac     8940

tgggtagatg gtgagcccac agaagccgag aaggattttt gggaacttgc atcccttgac     9000

tgttacaacc accttgctga gtggaaatca cttgaatact gttctacagc cagtatagac     9060

agtgagaacc ccccagacct aaataaaatc tggagtgaac cattttatca ggaaacatat     9120

ctaccttaca tgatccgcag caagctgaag ctgctgctcc agggagaggc tgaccagtcc     9180

ctgctgacat ttattgacaa agctatgcac ggggagctcc agaaggcgat tctagagctt     9240

cattacagtc aagagctgag tctgctttac ctcctgcaag atgatgttga cagagccaaa     9300

tattacattc aaaatggcat tcagagtttt atgcagaatt attctagtat tgatgtcctc     9360

ttacaccaaa gtagactcac caaattgcag tctgtacagg ctttaacaga aattcaggag     9420

ttcatcagct ttataagcaa acaaggcaat ttatcatctc aagttcccct taagagactt     9480

ctgaacacct ggacaaacag atatccagat gctaaaatgg acccaatgaa catctgggat     9540

gacatcatca caaatcgatg tttctttctc agcaaaatag aggagaagct tacccctctt     9600

ccagaagata atagtatgaa tgtggatcaa gatggagacc ccagtgacag gatggaagtg     9660

caagagcagg aagaagatat cagctccctg atcaggagtt gcaagttttc catgaaaatg     9720

aagatgatag acagtgcccg gaagcagaac aatttctcac ttgctatgaa actactgaag     9780

gagctgcata aagagtcaaa aaccagagac gattggctgg tgagctgggt gcagagctac     9840

tgccgcctga gccactgccg gagccggtcc cagggctgct ctgagcaggt gctcactgtg     9900

ctgaaaacag tctctttgtt ggatgagaac aacgtgtcaa gctacttaag caaaaatatt     9960

ctggctttcc gtgaccagaa cattctcttg ggtacaactt acaggatcat agcgaatgct    10020

ctcagcagtg agccagcctg ccttgctgaa atcgaggagg acaaggctag aagaatctta    10080

gagctttctg gatccagttc agaggattca gagaaggtga tcgcgggtct gtaccagaga    10140

gcattccagc acctctctga ggctgtgcag gcggctgagg aggaggccca gcctccctcc    10200

tggagctgtg ggcctgcagc tggggtgatt gatgcttaca tgacgctggc agatttctgt    10260

gaccaacagc tgcgcaagga ggaagagaat gcatcagtta ttgattctgc agaactgcag    10320

gcgtatccag cacttgtggt ggagaaaatg ttgaaagctt taaaattaaa ttccaatgaa    10380

gccagattga agtttcctag attacttcag attatagaac ggtatccaga ggagactttg    10440

agcctcatga caaaagagat ctcttccgtt ccctgctggc agttcatcag ctggatcagc    10500

cacatggtgg ccttactgga caaagaccaa gccgttgctg ttcagcactc tgtggaagaa    10560

atcactgata actacccgca ggctattgtt tatcccttca tcataagcag cgaaagctat    10620

tccttcaagg atacttctac tggtcataag aataaggagt ttgtggcaag gattaaaagt    10680

aagttggatc aaggaggagt gattcaagat tttattaatg ccttagatca gctctctaat    10740

cctgaactgc tctttaagga ttggagcaat gatgtaagag ctgaactagc aaaaacccct    10800

gtaaataaaa aaaacattga aaaaatgtat gaaagaatgt atgcagcctt gggtgaccca    10860

aaggctccag gcctgggggc ctttagaagg aagtttattc agacttttgg aaaagaattt    10920

gataaacatt ttgggaaagg aggttctaaa ctactgagaa tgaagctcag tgacttcaac    10980

gacattacca acatgctact tttaaaaatg aacaaagact caaagccccc tgggaatctg    11040

aaagaatgtt caccctggat gagcgacttc aaagtggagt tcctgagaaa tgagctggag    11100

attcccggtc agtatgacgg taggggaaag ccattgccag agtaccacgt gcgaatcgcc    11160

gggtttgatg agcgggtgac agtcatggcg tctctgcgaa ggcccaagcg catcatcatc    11220

cgtggccatg acgagaggga acaccctttc ctggtgaagg gtggcgagga cctgcggcag    11280

gaccagcgcg tggagcagct cttccaggtc atgaatggga tcctggccca agactccgcc    11340

tgcagccaga gggccctgca gctgaggacc tatagcgttg tgcccatgac ctccaggtta    11400

ggattaattg agtggcttga aaatactgtt accttgaagg accttctttt gaacaccatg    11460

tcccaagagg agaaggcggc ttacctgagt gatcccaggg caccgccgtg tgaatataaa    11520

gattggctga caaaaatgtc aggaaaacat gatgttggag cttacatgct aatgtataag    11580

ggcgctaatc gtactgaaac agtcacgtct tttagaaaac gagaaagtaa agtgcctgct    11640

gatctcttaa agcgggcctt cgtgaggatg agtacaagcc ctgaggcttt cctggcgctc    11700

cgctcccact tcgccagctc tcacgctctg atatgcatca gccactggat cctcgggatt    11760

ggagacagac atctgaacaa ctttatggtg gccatggaga ctggcggcgt gatcgggatc    11820

gactttgggc atgcgtttgg atccgctaca cagtttctgc cagtccctga gttgatgcct    11880

tttcggctaa ctcgccagtt tatcaatctg atgttaccaa tgaaagaaac gggccttatg    11940

tacagcatca tggtacacgc actccgggcc ttccgctcag accctggcct gctcaccaac    12000

accatggatg tgtttgtcaa ggagccctcc tttgattgga aaaattttga acagaaaatg    12060

ctgaaaaaag gagggtcatg gattcaagaa ataaatgttg ctgaaaaaaa ttggtacccc    12120

cgacagaaaa tatgttacgc taagagaaag ttagcaggtg ccaatccagc agtcattact    12180

tgtgatgagc tactcctggg tcatgagaag gcccctgcct tcagagacta tgtggctgtg    12240

gcacgaggaa gcaaagatca caacattcgt gcccaagaac cagagagtgg gctttcagaa    12300

gagactcaag tgaagtgcct gatggaccag gcaacagacc ccaacatcct tggcagaacc    12360

tgggaaggat gggagccctg gatgtga                                        12387


<210>  68
<211>  1641
<212>  DNA
<213>  Homo sapiens;

<400>  68
atggctaaca acagccccgc gctgacaggc aactcgcagc cgcagcacca ggcggctgca       60

gctgcggctc agcaacagca gcagtgcggc ggcggcggcg ctaccaagcc ggcggtctcc      120

ggcaagcagg gcaatgtgct cccgctctgg ggcaacgaga agaccatgaa cctcaacccc      180

atgatcctga ccaacatcct gtcgtcgcct tacttcaaag tacagctcta cgagctcaag      240

acctaccacg aggtggtgga cgagatctac tttaaggtca cgcacgttga accatgggag      300

aaaggaagca ggaaaacagc gggccagaca gggatgtgcg gaggggttcg aggtgttgga      360

acaggaggaa ttgtttctac agcattttgc ctgttataca aattatttac cctgaagtta      420

actcgaaagc aagtgatggg tcttataaca cacacagact ctccatatat tagagcgctt      480

ggatttatgt atataagata tacacagccc cctacagatc tgtgggactg gtttgaatcc      540

ttccttgatg atgaagagga cctagatgtg aaggctggtg gaggctgtgt aatgaccatt      600

ggagaaatgc tacgatcttt tctcacaaaa ctggagtggt tttctacctt gtttccaaga      660

attccagttc cagttcaaaa gaatattgat caacagatta aaacccgacc tagaaaaatc      720

aagaaagatg ggaaggaagg tgctgaggaa atagacagac atgttgaacg cagacgttca      780

aggtctccaa ggagatctct gagtccacgg aggtccccaa gaaggtcaag aagtagaagt      840

catcatcggg agggccatgg gtcttctagt tttgacagag aattagaaag agagaaagaa      900

cgccagcgac tagagcgtga agccaaagaa agggagaaag aacggcgaag atcccgaagt      960

attgaccggg ggttagaacg caggcgcagc agaagtaggg aaaggcatag aagtcgcagt     1020

cgaagtcgtg ataggaaagg ggatagaagg gacagggatc gagaaagaga gaaagaaaat     1080

gagagaggta gaagacgaga tcgtgactat gataaggaaa gaggaaatga acgagaaaaa     1140

gagagagagc gatcaagaga aaggtccaag gaacagagaa gtaggggaga ggtagaagag     1200

aagaaacata aagaagacaa agatgatagg cggcacagag atgacaaaag agattccaag     1260

aaagagaaaa aacacagtag aagcagaagc agagaaagga aacacagaag taggagtcga     1320

agtagaaatg cagggaaacg aagtagaagt agaagcaaag agaaatcaag taaacataaa     1380

aatgaaagta aagaaaaatc aaataaacga agtcgaagtg gcagtcaagg aagaactgac     1440

agtgttgaaa aatcaaaaaa acgggaacat agtcccagca aagaaaaatc tagaaagcgt     1500

agtagaagca aagaacgttc ccacaaacga gatcacagtg atagtaagga ccagtcagac     1560

aaacatgatc gtcgaaggag ccaaagtata gaacaagaga gccaagaaaa acagcataaa     1620

aacaaagatg agactgtgtg a                                               1641


<210>  69
<211>  1152
<212>  DNA
<213>  Homo sapiens;

<400>  69
atggcaggga ttccagggct cctcttcctt ctcttctttc tgctctgtgc tgttgggcaa       60

gtgagccctt acagtgcccc ctggaaaccc acttggcctg cataccgcct ccctgtcgtc      120

ttgccccagt ctaccctcaa tttagccaag ccagactttg gagccgaagc caaattagaa      180

gtatcttctt catgtggacc ccagtgtcat aagggaactc cactgcccac ttacgaagag      240

gccaagcaat atctgtctta tgaaacgctc tatgccaatg gcagccgcac agagacgcag      300

gtgggcatct acatcctcag cagtagtgga gatggggccc aacaccgaga ctcagggtct      360

tcaggaaagt ctcgaaggaa gcggcagatt tatggctatg acagcaggtt cagcattttt      420

gggaaggact tcctgctcaa ctaccctttc tcaacatcag tgaagttatc cacgggctgc      480

accggcaccc tggtggcaga gaagcatgtc ctcacagctg cccactgcat acacgatgga      540

aaaacctatg tgaaaggaac ccagaagctt cgagtgggct tcctaaagcc caagtttaaa      600

gatggtggtc gaggggccaa cgactccact tcagccatgc ccgagcagat gaaatttcag      660

tggatccggg tgaaacgcac ccatgtgccc aagggttgga tcaagggcaa tgccaatgac      720

atcggcatgg attatgatta tgccctcctg gaactcaaaa agccccacaa gagaaaattt      780

atgaagattg gggtgagccc tcctgctaag cagctgccag ggggcagaat tcacttctct      840

ggttatgaca atgaccgacc aggcaatttg gtgtatcgct tctgtgacgt caaagacgag      900

acctatgact tgctctacca gcaatgcgat gcccagccag gggccagcgg gtctggggtc      960

tatgtgagga tgtggaagag acagcagcag aagtgggagc gaaaaattat tggcattttt     1020

tcagggcacc agtgggtgga catgaatggt tccccacagg atttcaacgt ggctgtcaga     1080

atcactcctc tcaaatatgc ccagatttgc tattggatta aaggaaacta cctggattgt     1140

agggaggggt ga                                                         1152


<210>  70
<211>  1479
<212>  DNA
<213>  Homo sapiens;

<400>  70
atggcaaata actacaagaa aattgttcta ctgaaaggat tagaggtcat caatgattat       60

cattttagaa ttgttaagtc cttactgagt aacgatttaa aacttaatcc aaaaatgaaa      120

gaagagtatg acaaaattca gattgctgac ttgatggagg aaaagttccc aggtgatgcc      180

ggtttgggca aactaataga attcttcaaa gaaataccaa cactgggaga ccttgctgaa      240

actcttaaaa gagaaaagtt aaaagttgca aataaaattg aatccattcc agtcaaagga      300

ataatcccat ctaaaaagac gaaacagaaa gaagtgtatc ctgctacacc tgcatgcacc      360

ccaagcaacc gtctcacagc taaaggagca gaggagactc ttggacctca gaaaagaaaa      420

aaaccatctg aagaagagac tggaaccaaa aggagtaaga tgtccaaaga gcagactcgg      480

ccttcctgct ctgcaggagc cagcacgtcc acagccatgg gccgttcccc acctccccag      540

acctcatcat cagctccacc caacacttcc tcaactgaga gcctaaaacc attggccaac      600

cgtcacgcaa ctgccagtaa aaatattttc cgagaagacc caataatcgc gatggtacta      660

aatgcaacaa aagtatttaa atatgaatcc tcagaaaatg agcaaagaag aatgtttcat      720

gctacagtgg ctacgcagac acagttcttt catgtgaagg ttttaaacat caacttgaag      780

aggaaattca ttaaaaagag aatcatcatt atatcaaatt attccaaacg taatagtctc      840

ctagaggtga atgaagcctc ttctgtatct gaagctggtc ctgaccaaac gtttgaggtt      900

ccaaaggaca tcatcagaag agcaaagaaa attccgaaga tcaatattct tcacaaacaa      960

acttcaggat atattgtata tggattattt atgctacata cgaaaattgt aaataggaag     1020

acgacaatct atgaaattca ggataaaaca ggaagtatgg ctgtagtagg aaaaggagaa     1080

tgccacaata tcccctgtga aaaaggagat aagcttcgac tcttctgctt tcgactgaga     1140

aagagggaaa atatgtcaaa actgatgtca gaaatgcata gtttcatcca gatacagaaa     1200

aatacaaacc agagaagcca tgactccagg agcatggcac taccccagga acagagtcag     1260

catccaaaac cttcagaggc cagcacaacc ctacctgaaa gccatctcaa gactcctcag     1320

atgccaccaa caaccccatc cagcagttcc ttcaccaaga aggatgaaac ccacccagga     1380

gcacagtcat cgcctgcaaa ctttagaatc acctcaccaa ctgtggcccc tcctctttct     1440

tctgacactt ccaccaaccg ccatccagca gttccttaa                            1479


<210>  71
<211>  2331
<212>  DNA
<213>  Homo sapiens;

<400>  71
atgaataatt ccctagagaa caccatctcc tttgaagagt acatccgagt aaaggcacgg       60

tctgtcccgc aacacaggat gaaggaattt ctggactcac tggcctctaa ggggccagaa      120

gcccttcagg agttccagca gacagccacc actaccatgg tgtaccaaca gggtgggaac      180

tgcatataca cagacagcac tgaagtggct gggtctttgc ttgaacttgc ctgtccagtc      240

accaccagtg ttcagccaca aacccagcaa gaacagcaga tccaggttca gcagccgcag      300

caggttcagg tccaggtgca ggtacagcag tctccgcaac aggtctcggc tcagctctcc      360

ccacaactca ccgttcacca gcctactgag caacccatcc aggtccaggt gcagatccaa      420

ggccaggcac cacagtcagc agccccctcc attcagaccc cgtctctgca gagtcccagt      480

ccctcgcagc tgcaagcagc tcagatccag gtgcagcacg tgcaagcagc ccagcagatc      540

caggctgcag aaatcccgga ggagcacatc ccacatcagc aaatccaggc tcagctggtg      600

gctggccagt ctcttgctgg tggtcagcag atccaaatcc agaccgtggg tgccctttcc      660

ccaccaccat cccagcaggg ctcaccccgg gaaggggagc ggcgggttgg cacggccagt      720

gtcctccaac cagtgaagaa gcgcaaagtg gacatgccca tcactgtgtc ctacgccatc      780

tcagggcagc cggtggccac cgtgctggcc attccacagg gccagcagca gagttatgtg      840

tctttgaggc cagacttact gacagtagac agtgcccacc tgtacagtgc cactgggacc      900

attactagcc ctacaggaga aacctggacc atccctgttt attctgccca gccccggggg      960

gaccctcagc agcagagcat tacccacatt gccattcccc aggaagccta caacgcagtt     1020

cacgtcagtg gctcacccac agccctggca gctgttaagc tggaggatga caaggagaag     1080

atggtgggca ccacatctgt agtgaaaaac tcccatgaag aggtagtgca gacccttgca     1140

aactctctct ttccagcaca gttcatgaat ggcaacatcc acattccagt ggctgtgcag     1200

gctgtggcag gcacgtacca gaatacggct caaactgtcc atatatggga cccccaacag     1260

cagccgcagc agcaaactcc ccaggaacag acaccaccac cacagcagca gcagcagcaa     1320

ctccaagtta cttgttcagc tcaaactgtc caggttgctg aagttgaacc acagtcacag     1380

ccacagcctt ccccagaact tctgcttcca aattctttga agccagaaga agggcttgaa     1440

gtatggaaaa actgggccca gaccaagaat gctgaactag agaaggatgc tcagaacaga     1500

ttggcaccca ttgggaggcg ccaactgctg cgattccagg aagatctcat ctcctctgct     1560

gtggcagagt tgaattatgg gctctgtcta atgacacggg aagctcgaaa tggagaaggt     1620

gaaccctatg acccagatgt gctctactat attttcctgt gtattcaaaa gtatcttttt     1680

gaaaatggaa gggtagatga cattttctcc gatctttatt atgttcggtt cacggagtgg     1740

ctacatgaag ttctgaagga tgttcagccc cgggtcactc cacttggcta tgtcttgccc     1800

agccacgtga ctgaggagat gctatgggag tgcaagcagc ttggggctca ctccccctcc     1860

accttgctga ccaccctcat gttctttaat accaagtact tcctattgaa gacagtggac     1920

cagcacatga agctggcctt ctccaaggtc ttgcgacaga caaagaagaa cccctctaat     1980

cccaaggata aaagcacgag tatccggtac ttgaaggccc ttggaataca ccagactggc     2040

cagaaagtta cagatgacat gtatgcagaa cagacggaaa atccagagaa tccattgaga     2100

tgtcccatca agctctatga tttctacctc ttcaaatgcc cccagagtgt gaaaggccgg     2160

aatgacacct tttacctgac acctgagcca gtggtggccc ccaacagccc aatctggtac     2220

tcagtccagc ctatcagcag agagcagatg ggacaaatgc tgacgcggat cctggtgata     2280

agagaaattc aggaggccat cgcagtggcc aatgcaagca ctatgcactg a              2331


<210>  72
<211>  678
<212>  DNA
<213>  Homo sapiens;

<400>  72
atggcgggcg gaggagccgg ggaccccggc ctgggggcgg ccgccgcccc agcgcccgag       60

acccgcgagc acctcttcaa ggtgctggtg atcggcgagc ttggcgtggg caagaccagc      120

atcatcaagc gctacgtcca ccagctcttc tcccagcact accgggccac catcggggtg      180

gacttcgccc tcaaggtcct caactgggac agcaggactc tggtgcgcct gcagctgtgg      240

gacatcgcgg ggcaggagcg atttggcaac atgacccgag tatactacaa ggaagctgtt      300

ggtgcttttg tagtctttga tatatcaaga agttccacat ttgaggcagt cttaaaatgg      360

aaaagtgatc tggatagtaa agttcatctt ccaaatggca gccctatccc tgctgtcctc      420

ttggctaaca aatgtgacca gaacaaggac agtagccaga gtccttccca ggtggaccaa      480

ttctgcaaag aacatggctt tgccggatgg tttgaaacct ctgcaaagga taacataaac      540

atagaggaag ctgcccggtt cctagtggag aagattcttg taaaccacca aagctttcct      600

aatgaagaaa acgatgtgga caaaattaag ctagatcaag agaccttgag agcagagaac      660

aaatcccagt gttgctga                                                    678


<210>  73
<211>  2934
<212>  DNA
<213>  Homo sapiens;

<400>  73
atgaggactg cggggcggga ccctgtgccg cggcggagtc caagatggcg gcgtgcggtt       60

ccgctgtgtg aaacgagcgc ggggcggcgg gttactcagc tccgcggaga cgacctccga      120

cgacccgcaa caatgaaggg aaaagagcgc tcgccagtga aggccaaacg ctcccgtggt      180

ggtgaggact cgacttcccg cggtgagcgg agcaagaagt tagggggctc tggtggcagc      240

aatgggagca gcagcggaaa gaccgatagc ggcggtgggt cgcggcggag tctccacctg      300

gacaagtcca gcagtcgagg tggcagccgc gagtatgata ccggtggggg cagctccagt      360

agccgcttgc atagttatag ctccccgagc accaaaaatt cttcgggcgg gggcgaatcg      420

cgcagcagct cccggggtgg aggcggggag tcacgttcct ctggggccgc ctcctcagct      480

cccggcggcg gggacggcgc ggaatacaag actctgaaga taagcgagtt ggggtcccag      540

cttagtgacg aagcggtgga ggacggcctg tttcatgagt tcaaacgctt cggtgatgta      600

agtgtgaaaa tcagtcatct gtcgggttct ggcagcgggg atgagcgggt agcctttgtg      660

aacttccggc ggccagagga cgcgcgggcg gccaagcatg ccagaggccg cctggtgctc      720

tatgaccggc ctctgaagat agaagctgtg tatgtgagcc ggcgccgcag ccgctcccct      780

ttagacaaag atacttatcc tccatcagcc agtgtggtcg gggcctctgt aggtggtcac      840

cggcaccccc ctggaggtgg tggaggccag agatcacttt cccctggtgg cgctgctttg      900

ggatacagag actaccggct gcagcagttg gctcttggcc gcctgccccc tccacctccg      960

ccaccattgc ctcgagacct ggagagagaa agagactacc cgttctatga gagagtgcgc     1020

cctgcataca gtcttgagcc aagggtggga gctggagcag gtgctgctcc tttcagagaa     1080

gtggatgaga tttcacccga ggatgatcag cgagctaacc ggacgctctt cttgggcaac     1140

ctagacatca ctgtaacgga gagtgattta agaagggcgt ttgatcgctt tggagtcatc     1200

acagaagtag atatcaagag gccttctcgc ggccagacta gtacttacgg ctttctcaaa     1260

tttgagaact tagatatgtc tcaccgggcc aaattagcaa tgtctggcaa aattataatt     1320

cggaatccta tcaaaattgg ttatggtaaa gctacaccca ccacccgcct ctgggtggga     1380

ggcctgggac cttgggttcc tcttgctgcc ctggcacgag aatttgatcg atttggcacc     1440

atacgcacca tagactaccg aaaaggtgat agttgggcat atatccagta tgaaagcctg     1500

gatgcagcgc atgctgcctg gacccatatg cggggcttcc cacttggtgg cccagatcga     1560

cgccttagag tagactttgc cgacaccgaa catcgttacc agcagcagta tctgcagcct     1620

ctgcccttga ctcattatga gctggtgaca gatgcttttg gacatcgggc accagaccct     1680

ttgaggggtg ctcgggatag gacaccaccc ttactataca gagatcgtga tagggacctt     1740

tatcctgact ctgattgggt gccaccccca cccccagtcc gagaacgcag cactcggact     1800

gcagctactt ctgtgcctgc ttacgagcca ctggatagcc tagatcgcag gcgggatggt     1860

tggtccttgg accgggacag aggtgatcga gatctgccca gcagcagaga ccagcctagg     1920

aagcgaaggc tgcctgagga gagtggagga cgtcatctgg ataggtctcc tgagagtgac     1980

cgcccacgaa aacgtcactg cgctccttct cctgaccgca gtccagaatt gagcagtagc     2040

cgggatcgtt acaacagcga caatgatcga tcttcccgtc ttctcttgga aaggccctct     2100

ccaatcagag acagacgagg tagtttggag aagagccagg gtgacaagcg agaccgtaaa     2160

aactctgcat cagctgaacg agataggaag caccggacaa ctgctcccac tgagggaaaa     2220

agccctctga aaaaagaaga ccgctctgat gggagtgcac ctagcaccag cactgcttcc     2280

tccaagctga agtccccgtc ccagaaacag gatgggggga cagcccctgt ggcatcagcc     2340

tctcccaaac tctgtttggc ctggcagggc atgcttctac tgaagaacag caactttcct     2400

tccaacatgc atctgttgca gggtgacctc caagtggcta gtagtcttct tgtggagggt     2460

tcaactggag gcaaagtggc ccagctcaag atcactcagc gtctccgttt ggaccagccc     2520

aagttggatg aagtaactcg acgcatcaaa gtagcagggc ccaatggtta tgccattctt     2580

ttggctgtgc ctggaagttc tgacagccgg tcctcctctt cctcagctgc atcagacact     2640

gccacttcta ctcagaggcc acttaggaac cttgtgtcct atttaaagca aaagcaggca     2700

gccggggtga tcagcctccc tgtggggggc aacaaagaca aggaaaacac cggggtcctt     2760

catgccttcc caccttgtga gttctcccag cagttcctgg attcccctgc caaggcactg     2820

gccaaatctg aagaagatta cctggtcatg atcattgtcc gtgggtttgg ttttcagata     2880

ggagttaggt atgagaacaa gaagagagaa aacttggcgc tgaccctgtt atag           2934


<210>  74
<211>  1272
<212>  DNA
<213>  Homo sapiens;

<400>  74
atggcatctg atgactttga catagtgatt gaggccatgc tggaagctcc ctataaaaaa       60

gaagaggatg agcaacaaag gaaagaagtt aaaaaggatt atcctagcaa taccaccagc      120

agcaccagca acagtggcaa tgagaccagt ggaagcagca ccatcgggga gacaagcaat      180

cgtagtcgag atcgggatcg gtatagacgg agaaatagtc ggagccgaag tccaggtcgg      240

cagtgtcgtc accgtagccg tagctgggat cgtcgacatg gtagtgagtc gcgaagtcgg      300

gaccatcgtc gtgaggatcg tgtgcattac aggagtcctc cacttgccac tggttatagg      360

tatggacaca gtaagagtcc tcatttcaga gagaagagcc cagtcaggga gccagttgat      420

aatctgagtc ctgaggagcg tgatgcccgc acagttttct gtatgcagtt agctgcccga      480

attcggcctc gagatctgga ggactttttc tctgctgtag gcaaggttcg cgatgtacgt      540

atcatctcag atcggaactc acgtcgttct aagggcattg cctacgtgga attctgtgaa      600

atccagtctg tgccactggc cattgggctg actgggcagc ggttgctggg agtgcctatc      660

attgtacagg cttcacaggc agagaaaaac cgactggcag ccatggccaa caacctgcaa      720

aagggcaatg gtggaccaat gcgcctctat gtgggttccc tgcacttcaa tatcactgaa      780

gacatgctcc ggggcatctt tgagcccttt ggtaaaattg ataatattgt cctgatgaag      840

gactcagata caggccgctc taaaggttat ggtttcatca cgttctctga ttctgagtgt      900

gcccggcggg ccctggaaca gttgaatggg tttgagcttg ctggtcgacc tatgagggtt      960

ggccatgtga ctgagcgact ggatggtggc acagacatca cttttcctga tggggaccag     1020

gagctggatc tgggatcagc aggtggacgt tttcagctca tggcaaaact ggcagaaggc     1080

gctggaatcc aactgccaag cactgctgct gctgctgctg ccgccgccgc ccaggctgct     1140

gccttgcaac tgaatggagc agttcccttg ggggccctga atccagcagc tctgactgct     1200

ctgagtccag ccctgaacct tgcctcccag tgtttccagc tctccagcct ctttaccccc     1260

cagaccatgt aa                                                         1272


<210>  75
<211>  3444
<212>  DNA
<213>  Homo sapiens;

<400>  75
atggacattc ggaaattctt tggagtaata ccaagtggaa agaaacttgt aagtgaaaca       60

gtaaagaaga atgagaaaac aaagtctgat gaagaaactt taaaagcaaa gaaaggaata      120

aaggaaatca aggtaaatag ctcccgtaaa gaggatgact tcaaacaaaa gcaaccaagc      180

aagaaaaaga ggatcatcta tgattcagat tcagagtcag aggagacgtt gcaggtaaaa      240

aatgccaaaa agccaccaga aaaactgcca gtatcttcta aacctggtaa aatttcacgg      300

caggatcctg ttacatacat ttcagaaaca gatgaagaag atgactttat gtgtaagaag      360

gcggcctcta aatcaaaaga gaatggaaga tctacaaata gtcatcttgg aacatcaaac      420

atgaaaaaga atgaagaaaa cactaagacc aagaataagc ctttatcacc aataaaactt      480

acacccacat cagtacttga ttattttgga actggaagtg tccaaagatc taataagaag      540

atggtggcaa gcaaaagaaa agagctttca caaaatacag atgagtctgg attaaatgat      600

gaagccatcg ccaagcaatt acagcttgat gaagatgcgg agctggagag gcagttgcat      660

gaagatgaag agtttgccag aacattagcc atgttggatg aagaacccaa gaccaaaaag      720

gctcgaaagg acacagaagc gggagaaacg ttttcatctg tccaagccaa tttaagtaaa      780

gcagaaaaac ataaatatcc tcataaagta aaaacagcac aagtttcaga tgaaagaaag      840

agctacagtc ctaggaagca aagtaaatat gaaagttcaa aagaatctca gcaacattcc      900

aagtcatcag ctgacaaaat aggagaagtc tcttctccca aggccagttc taagctggca      960

attatgaaaa gaaaagaaga gagctcttat aaagaaatag agcctgtggc ctcaaaaaga     1020

aaagaaaatg ccattaaatt gaaaggagag acaaaaactc ctaagaaaac caaaagttct     1080

ccagctaaaa aagagtctgt aagtcctgaa gattctgaaa agaaacgcac taattatcaa     1140

gcttatcgaa gctacttaaa tcgagaaggt cccaaggctc tgggctccaa agaaatacca     1200

aagggagctg aaaattgctt ggaaggcctt atatttgtaa tcacaggcgt gctggagtct     1260

attgaacgag atgaggccaa gtctctaatt gaacgttatg ggggaaaagt aacaggaaat     1320

gtcagcaaga aaacaaatta tcttgtcatg ggtcgtgata gtggacagtc caagagtgat     1380

aaggccgcag ccttggggac aaaaattatt gatgaagatg gcctgttgaa tctgattcgg     1440

actatgccag gcaagaaatc caagtatgaa atagcagttg aaactgagat gaagaaagag     1500

tccaaactgg agagaacacc ccaaaaaaat gtccaaggaa aaagaaaaat tagtccatct     1560

aaaaaggaat cagaatctaa aaagagcagg ccgacttcca aaagggacag tttggcaaag     1620

acaataaaaa aggaaacaga tgtgttttgg aaaagcctgg atttcaagga gcaggtggct     1680

gaggagacaa gtggtgacag caaggctagg aatttggctg atgacagcag tgaaaacaaa     1740

gtggaaaatt tgctctgggt ggataaatat aagccaacct cgctcaagac cataattgga     1800

cagcaaggtg accagagctg tgccaacaaa ctcctacgct ggctccgaaa ctggcaaaag     1860

agttcttccg aagataaaaa acacgcaaag tttggtaaat tttccggcaa agatgatggc     1920

tctagtttta aagcagcgtt gctgtcaggc cctcctggtg ttggcaaaac caccacagct     1980

tccctggtgt gtcaggagtt gggatacagc tacgtggaac tgaatgcaag tgacacccgg     2040

agtaagagca gtttgaaggc gattgttgct gagtcactga acaataccag catcaaaggc     2100

ttttattcaa atggagcagc ctcttcagta agcacgaaac atgctctcat catggatgaa     2160

gtagatggca tggcaggcaa tgaggatagg ggaggaattc aggaattaat tggcctgata     2220

aaacatacta aaattcccat tatttgtatg tgcaatgata gaaatcatcc caagattcgc     2280

tctctggttc attattgttt tgatcttcgt tttcaaagac ctcgggttga acagattaag     2340

ggtgctatga tgtctattgc atttaaagaa ggtttaaaga ttccccctcc agctatgaat     2400

gaaataattt tgggagccaa tcaagatatc agacaggttt tacataatct gagtatgtgg     2460

tgtgcacgaa gtaaagcatt aacctatgac caggccaaag ctgattctca cagagccaaa     2520

aaggatatca aaatgggccc atttgatgtt gcccggaaag tgtttgcagc tggagaggag     2580

actgctcaca tgtcacttgt ggacaagtca gatctctttt ttcatgatta ttcaatagca     2640

cccctcttcg tccaggaaaa ttacatacac gtgaagcctg tagcagcagg gggtgacatg     2700

aaaaagcacc tgatgctttt aagcagagca gcagacagca tatgcgatgg tgacctagtg     2760

gacagccaga tccggagtaa gcaaaactgg agtcttctgc ctgcgcaggc catttatgcc     2820

agtgttcttc ctggagagtt gatgaggggg tacatgaccc agtttcccac cttcccaagc     2880

tggctgggga agcactcgtc tacaggcaaa catgatcgta ttgttcagga cctggccttg     2940

catatgagtc tcagaactta ctccagcaaa aggactgtaa acatggatta tctgtcgctt     3000

ctaagggatg cacttgtaca gcccttgacc tcacaaggag tagacggagt acaggatgtt     3060

gttgcactta tggacacata ttatttgatg aaagaagact ttgagaatat catggaaatc     3120

agcagctggg gtggcaaacc tagtcccttt tcaaagctgg atcccaaggt gaaagcagcc     3180

ttcacaagag cttacaataa ggaagcccac cttactccat actcacttca agctataaag     3240

gcatctagac acagcacaag cccatccctg gattcggaat acaatgaaga attaaatgaa     3300

gatgactctc aatctgatga gaaagaccaa gatgctatag aaactgatgc catgatcaag     3360

aaaaagacaa aatcttcaaa gccttcaaaa ccagaaaaag ataaggagcc cagaaaagga     3420

aaaggaaaaa gttcgaagaa atga                                            3444


<210>  76
<211>  453
<212>  DNA
<213>  Homo sapiens;

<400>  76
atggtgctat gctttcctct tcttttactg ctgctggttc tatggggacc agtgtgtcca       60

cttcatgctt ggcctaagcg tctcaccaag gctcactggt ttgaaattca gcatatacag      120

ccaagtcctc tccaatgcaa cagggcaatg agtggcatca acaattatac ccagcactgt      180

aagcatcaaa atacctttct gcatgactct ttccagaatg tggctgctgt ctgtgatttg      240

ctcagcattg tctgcaaaaa tcgtcggcac aactgccacc agagctcaaa gcctgtcaac      300

atgactgact gcagactcac ttcaggaaag tatccccagt gccgctatag tgctgctgcc      360

cagtacaaat tcttcattgt tgcctgtgac ccccctcaga agagcgatcc cccctacaag      420

ttggttcctg tacacttaga tagtattctc taa                                   453


<210>  77
<211>  1500
<212>  DNA
<213>  Homo sapiens;

<400>  77
atggcatcaa acagcctctt cagcacagtg acaccatgtc agcaaaactt cttttgggat       60

ccgagcacca gccggcgctt cagccccccc tccagcagcc tgcagcccgg caaaatgagc      120

gacgtgagcc cggtggtggc tgcgcaacag cagcagcaac agcagcagca gcaacagcag      180

cagcagcagc agcaacagca gcagcagcag caggaggcgg cggcggcggc tgcggcggcg      240

gcggcggctg cggcggcggc agctgcagtg ccccggttgc ggccgcccca cgacaaccgc      300

accatggtgg agatcatcgc cgaccacccg gccgaactcg tccgcaccga cagccccaac      360

ttcctgtgct cggtgctgcc ctcgcactgg cgctgcaaca agaccctgcc cgtggccttc      420

aaggtggtag ccctcggaga ggtaccagat gggactgtgg ttactgtcat ggcgggtaac      480

gatgaaaatt attctgctga gctccggaat gcctctgctg ttatgaaaaa ccaagtagca      540

aggttcaacg atctgagatt tgtgggccgg agtggacgag gcaagagttt caccttgacc      600

ataaccgtct tcacaaatcc tccccaagta gctacctatc acagagcaat taaagttaca      660

gtagatggac ctcgggaacc cagaaggcac agacagaagc ttgatgactc taaacctagt      720

ttgttctctg accgcctcag tgatttaggg cgcattcctc atcccagtat gagagtaggt      780

gtcccgcctc agaacccacg gccctccctg aactctgcac caagtccttt taatccacaa      840

ggacagagtc agattacaga ccccaggcag gcacagtctt ccccgccgtg gtcctatgac      900

cagtcttacc cctcctacct gagccagatg acgtccccgt ccatccactc taccaccccg      960

ctgtcttcca cacggggcac tgggcttcct gccatcaccg atgtgcctag gcgcatttca     1020

ggtgcttcag aactgggccc tttttcagac cccaggcagt tcccaagcat ttcatccctc     1080

actgagagcc gcttctccaa cccacgaatg cactatccag ccacctttac ttacaccccg     1140

ccagtcacct caggcatgtc cctcggtatg tccgccacca ctcactacca cacctacctg     1200

ccaccaccct accccggctc ttcccaaagc cagagtggac ccttccagac cagcagcact     1260

ccatatctct actatggcac ttcgtcagga tcctatcagt ttcccatggt gccgggggga     1320

gaccggtctc cttccagaat gcttccgcca tgcaccacca cctcgaatgg cagcacgcta     1380

ttaaatccaa atttgcctaa ccagaatgat ggtgttgacg ctgatggaag ccacagcagt     1440

tccccaactg ttttgaattc tagtggcaga atggatgaat ctgtttggcg accatattga     1500


<210>  78
<211>  1824
<212>  DNA
<213>  Homo sapiens;

<400>  78
atgcgtgggg cggcgcggct ggggcggccg ggccggagtt gcctcccggg ggcccgcggc       60

ctgagggccc cgccgccgcc gccgctgctg cttctgcttg cgctgttgcc gctgctgccc      120

gcgcctggcg ctgccgccgc ccccgccccg cggcccccgg agctgcagtc ggcttccgcg      180

gggcccagcg tgagtctcta cctgagcgag gacgaggtgc gccggctgat cggtcttgat      240

gcagaacttt attatgtgag aaatgacctt attagtcact acgctctatc ctttagtctg      300

ttagtaccca gtgagacaaa tttcctgcac ttcacctggc atgcgaagtc caaggttgaa      360

tataagctgg gattccaagt ggacaatgtt ttggcaatgg atatgcccca ggtcaacatt      420

tctgttcagg gggaagttcc acgcacttta tcagtgtttc gggtagagct ttcctgtact      480

ggcaaagtag attctgaagt tatgatacta atgcagctca acttgacagt aaattcttca      540

aaaaatttta ccgtcttaaa ttttaaacga aggaaaatgt gctacaaaaa acttgaagaa      600

gtaaaaactt cagccttgga caaaaacact agcagaacta tttatgatcc tgtacatgca      660

gctccaacca cttctacgcg tgtgttttat attagtgtag gggtttgttg tgcagtaata      720

tttctcgtag caataatatt agctgttttg caccttcata gtatgaaaag gattgaactg      780

gatgacagca ttagtgccag cagtagttcc caagggctgt ctcagccatc cacccagacg      840

actcagtatc tgagagcaga cacgcccaac aatgcaactc ctatcaccag ttatcctacc      900

ttgcggatag agaagaacga cttgagaagt gtcactcttt tggaggccaa aggcaaggtg      960

aaggatatag caatatccag agagaggata actctaaaag atgtactcca agaaggtact     1020

tttgggcgta ttttccatgg gattttaata gatgaaaaag atccaaataa agaaaaacaa     1080

gcatttgtca aaacagttaa agatcaagct tctgaaattc aggtgacaat gatgctcact     1140

gaaagttgta agctgcgagg tcttcatcac agaaatcttc ttcctattac tcatgtgtgt     1200

atagaagaag gagaaaagcc catggtgata ttgccttaca tgaattgggg gaatcttaaa     1260

ttgtttttac gacagtgcaa gttagtagag gccaataatc cacaggcaat ttctcagcaa     1320

gacctggtac acatggctat tcagattgcc tgtggaatga gctacctggc cagaagggaa     1380

gtcatccaca aagacctggc tgccaggaac tgtgtcattg atgacacact tcaagttaag     1440

atcacagaca atgccctctc cagagacttg ttccccatgg actatcactg tctgggggac     1500

aatgaaaaca ggccagttcg ttggatggct cttgaaagtc tggttaataa cgagttctct     1560

agcgctagtg atgtgtgggc ctttggagtg acgctgtggg aactcatgac tctgggccag     1620

actccctacg tggacattga ccccttcgag atggccgcat acctgaaaga tggttaccga     1680

atagcccagc caatcaactg tcctgatgaa ttatttgctg tgatggcctg ttgctgggcc     1740

ttagatccag aggagaggcc caagtttcag cagctggtac agtgcctaac agagtttcat     1800

gcagccctgg gggcctacgt ctga                                            1824


<210>  79
<211>  3147
<212>  DNA
<213>  Homo sapiens;

<400>  79
atgggccctc cgcggcaccc ccaggccggc gagatagaag cgggcggtgc gggcggcggg       60

cggcggctac aggtggaaat gagttctcaa cagtttcctc ggttaggagc cccttctacc      120

gggctgagcc aggccccttc tcagattgca aacagtggtt ctgctggatt gataaaccca      180

gctgctacag tcaatgatga atctggtcga gattctgaag tcagtgccag ggagcacatg      240

agttccagca gctccctcca gtcccgggag gagaagcaag agcctgttgt ggtaaggccc      300

tatccacagg tgcagatgtt gtcgacacac catgctgtcg catcagccac acctgttgca      360

gtgacagccc cgccagcaca cctgacgcca gcagtgccac tttcattttc ggagggactt      420

atgaagccgc ccccgaagcc caccatgcct agccgtccca ttgctcctgc tccaccttct      480

accctgtcac ttccccccaa ggttccaggg caggttaccg ttaccatgga gagtagcatc      540

cctcaagctt cagccattcc tgtggcaaca atcagtggac aacagggcca tcccagtaac      600

ctgcatcaca tcatgactac aaatgtgcaa atgtctatca tccgcagcaa tgctcctggg      660

ccccctcttc acattggagc ttctcattta cctcgaggtg cagctgctgc tgctgtgatg      720

tccagttcta aagtaaccac agtcctgagg ccgacctcac agctgccaaa tgctgctact      780

gctcagccag cagtacagca catcattcac caaccaatcc agtctcggcc acctgtgacc      840

acctccaatg ccatccctcc tgctgtggta gcaactgtct cagccaccag agctcagtct      900

ccagtcatca ctacgacagc ggcgcatgct actgattcag cacttagtag gccaaccttg      960

tctatccagc atcctccatc tgcagcaatc agtattcagc gtcctgccca gtcacgagat     1020

gtcacaacaa gaatcacact accatctcac cctgcattag ggacgccaaa acagcagctt     1080

catacaatgg ctcagaaaac aatcttcagt actggcacgc cagtggctgc agccacagta     1140

gcacctattt tggcaaccaa caccattcct tcagcgacca cagctggatc tgtgtcacac     1200

acgcaagctc ccacaagtac cattgttacc atgacagtac cctcccattc ctcccatgct     1260

actgctgtga ccacctcaaa catcccagtc gccaaggtgg tgccccagca gatcacgcac     1320

acttctcctc ggatccagcc agactaccct gccgagagga gtagcctgat tcccatctcc     1380

ggacatcggg cctctcccaa tcctgtggcc atggaaaccc gaagtgacaa cagaccgtct     1440

gttcccgttc agttccaata ttttttgcca acttaccccc cttctgcata cccactggcg     1500

gcacatacct acaccccaat caccagttcc gtgtccacta tccgacagta tccagtttca     1560

gctcaggctc caaactctgc catcacagct cagactggtg ttggggtagc gtctaccgtc     1620

cacctaaacc ccatgcagtt gatgacagtg gatgcatcgc atgctcgaca tattcaaggg     1680

atccagccag cacccatcag tacccagggt atccagccgg cccccattgg gaccccaggg     1740

atacagcctg caccacttgg cacacaggga attcactcag caaccccaat caacacacaa     1800

gggcttcagc ctgcacctat gggtactcag cagcctcagc ctgaaggaaa gacttcagca     1860

gtggtgttgg cagatggagc cacaattgtg gccaacccta ttagcaatcc attcagtgct     1920

gctccagcag caacaaccgt ggtgcagacc cacagccaga gtgctagcac caacgctccc     1980

gcccagggct catcgccacg gccaagcata ctccggaaga aacctgccac agatggtgcc     2040

aaacccaagt ctgaaatcca cgtgtctatg gccactccgg tcactgtgtc catggagact     2100

gtatccaatc aaaataatga tcagcctacc attgccgtcc ctccaactgc ccagcagccc     2160

ccaccgacca ttccaactat gattgcagca gccagtcccc cgtcacaacc agccgttgcc     2220

ctttcaacca ttcctggagc ggtccccatc actccaccca tcaccaccat tgcagctgca     2280

ccacctccat cagtcactgt gggtggcagt ctttcctccg tcttgggccc tcccgttcct     2340

gaaattaaag tgaaagaaga agtagaacca atggatatca tgaggccagt ttctgcagtt     2400

cctccactgg ctaccaacac tgtgtctcca tctcttgcat tgctggcaaa caacttgtcc     2460

atgcctacaa gtgacctacc acctggtgcc tccccaagga aaaagcctcg aaagcaacag     2520

catgtgatct caacagaaga aggtgacatg atggagacaa acagcactga tgatgagaag     2580

tccactgcca agagtcttct ggtgaaggct gagaagcgca agtctcctcc caaggagtat     2640

attgatgagg aaggtgtgag atatgtccca gtgcgtccaa gaccccccat tactttgctt     2700

cgtcactatc ggaacccctg gaaagctgct taccaccact ttcagaggta cagtgacgtc     2760

cgggtcaaag aggagaagaa agctatgctg caggaaatag ctaatcagaa aggagtatcc     2820

tgtcgtgctc aaggctggaa agtccacctc tgtgctgccc agttactaca gctgacgaat     2880

ctagaacatg atgtctatga aagacttact aacctgcagg aagggattat cccaaagaaa     2940

aaagcagcaa cagatgatga tctccaccga ataaacgaac tgatacaggg aaatatgcag     3000

aggtgtaaac ttgtgatgga tcaaatcagt gaagccagag actccatgct taaggtttta     3060

gatcataaag accgtgtcct gaagctgctt aacaagaacg ggactgtcaa aaaagtgtcc     3120

aaattgaagc gaaaggaaaa agtctag                                         3147


<210>  80
<211>  2589
<212>  DNA
<213>  Homo sapiens;

<400>  80
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca       60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcacctggtg      120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac      180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag      240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag      300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc      360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta      420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca      480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat      540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa      600

tatgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgacgtgat ccgaaaaagc      660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg      720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtgtg caagggggac      780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc      840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg      900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg      960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg     1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc     1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac     1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg     1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tgtgaactac     1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt     1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc     1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca     1440

aagaagggca acaggtttgt ctatgctggc tctaactcgg gcgtggtcca ggccccgctg     1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc     1560

gcctggagcc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg     1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggataaaag taaaggaagt     1680

taccggcagc attttttcaa gcacggtggc acagcggaac tgaaatgctc ccaaaaatcc     1740

aacctggccc gggtcttttg gaagttccag aatggcgtgt tgaaggccga gagccccaag     1800

tacggtctta tgggcagaaa aaacttgctc atcttcaact tgtcagaagg agacagtggg     1860

gtgtaccagt gcctgtcaga ggagagggtt aagaacaaaa cggtcttcca agtggtcgcc     1920

aagcacgtcc tggaagtgaa ggtggttcca aagcccgtag tggcccccac cttgtcagtt     1980

gttcagacag aaggtagtag gattgccacc aaagtgttgg tggcatccac ccaagggtct     2040

tctcccccaa ccccagccgt gcaggccacc tcctccgggg ccatcaccct tcctcccaag     2100

cctgcgccca ccggcacatc ctgcgaacca aagatcgtca tcaacacggt cccccagctc     2160

cactcggaga aaaccatgta tcttaagtcc agcgacaacc gcctcctcat gtccctcttc     2220

ctcttcttct ttgttctctt cctctgcctc tttttctaca actgctataa gggatacctg     2280

cccagacagt gcttgaaatt ccgctcggcc ctactaattg ggaagaagaa gcccaagtca     2340

gatttctgtg accgtgagca gagcctgaag gagacgttag tagagccagg gagcttctcc     2400

cagcagaatg gggagcaccc caagccagcc ctggacaccg gctatgagac cgagcaagac     2460

accatcacca gcaaagtccc cacggatagg gaggactcac agaggatcga cgacctttct     2520

gccagggaca agccctttga cgtcaagtgt gagctgaagt tcgctgactc agacgcagat     2580

ggagactga                                                             2589


<210>  81
<211>  2484
<212>  DNA
<213>  Homo sapiens;

<400>  81
atgcgcggct gcctgcggct cgcgctgctc tgcgcgctgc cctggctcct gctggcggcg       60

tcgcccgggc acccggcgaa atcccccagg cagcccccgg caccgcgccg cgaccccttc      120

gacgctgcca ggggcgccga tttcgatcat gtctacagcg gggtggtgaa cctcagcacc      180

gagaacatct actctttcaa ctacaccagc cagcccgacc aggtgacagc cgtgagggtg      240

tatgtgaaca gttcctctga gaatctcaac tacccggtcc ttgttgtggt tcgccagcag      300

aaagaggtgc tgtcctggca ggttcctctg ctcttccaag gactatacca gaggagctac      360

aactatcaag aagtgagccg caccttatgt ccctcagaag caaccaatga gacgggaccc      420

ttgcagcaac tgatatttgt agatgtcgca tccatggcac ccctgggtgc tcagtacaaa      480

ctgctagtta ccaagctgaa gcacttccag ctccggacaa atgttgcctt tcactttact      540

gccagcccct ctcaacctca gtattttcta tacaagtttc ccaaagacgt ggactcagtt      600

atcattaaag tggtgtctga aatggcttat ccatgttctg ttgtctcagt ccagaatatc      660

atgtgcccgg tgtatgatct cgaccacaat gtggaattta atggtgtcta tcagtccatg      720

accaagaaag ctgccatcac gctacagaag aaggattttc caggcgagca gttcttcgtg      780

gtatttgtga taaagcctga agattatgcc tgtggaggat ctttcttcat ccaggaaaag      840

gaaaaccaga cctggaatct acagcgaaaa aagaaccttg aagtgaccat tgtcccttcc      900

attaaagaat ctgtttatgt gaaatccagt cttttcagtg tcttcatctt cctgtccttc      960

tacttgggat gccttcttgt tgggtttgtt cattatctga ggtttcagag aaaatccatt     1020

gatggaagct ttgggtccaa tgatggctct ggaaatatgg tggcatctca tcccattgct     1080

gccagcacac ccgaagggag caattatggg acaatagatg agtcaagctc cagtcctgga     1140

aggcagatgt cctcctccga tggtgggcca ccgggccagt cagacacaga cagctccgtg     1200

gaggagagcg acttcgacac catgccagac attgagagtg ataaaaacat catccggacc     1260

aagatgttcc tttacctgtc agatttgtcc aggaaggacc ggagaattgt cagcaaaaaa     1320

tataaaattt atttttggaa catcatcacc attgctgtgt tttacgcgct gcccgtgatc     1380

cagctggtca ttacctatca gacagtggta aatgtcactg gcaaccagga catctgttac     1440

tacaacttcc tctgtgctca ccccttgggc gtcctgagtg ccttcaacaa cattctcagc     1500

aatctgggcc acgtgcttct gggcttcctc ttcctgctga tagtcttgcg ccgcgacatc     1560

ctccatcgga gagccctgga agccaaggac atctttgctg tggagtacgg gattcccaaa     1620

cactttggtc tcttctacgc tatgggcatt gcattgatga tggaaggggt gctcagtgct     1680

tgctaccatg tctgccctaa ttattccaac ttccaattcg acacctcctt catgtacatg     1740

atcgctggcc tgtgcatgct gaagctctat cagacccgcc acccagacat caatgccagc     1800

gcctactctg cctatgcctc ctttgctgtg gtcatcatgg tcaccgtcct tggagtggtg     1860

tttggaaaaa atgacgtatg gttctgggtc atcttctctg caatccacgt tctggcctcg     1920

ctagccctca gcacccagat atattatatg ggtcgtttca agatagattt gggaattttc     1980

cggcgggctg ccatggtgtt ctacacagac tgtatccagc agtgtagccg acctctatat     2040

atggatagaa tggtgttgct ggttgtgggg aatctggtta actggtcctt cgccctcttt     2100

ggattgatat accgccccag ggactttgct tcctacatgc tgggcatctt catctgtaac     2160

cttttgctgt acctggcctt ttacatcatc atgaagctcc gcagctctga aaaggtcctc     2220

ccagtcccgc tcttctgcat cgtggccacc gctgtgatgt gggctgccgc cctatatttt     2280

ttcttccaga atctcagcag ctgggaggga actccggccg aatcccggga gaagaaccgc     2340

gagtgcattc tgctggattt cttcgatgac catgacatct ggcacttcct ctctgctact     2400

gctctgtttt tctcattctt ggttttgtta actttggatg atgaccttga tgtggttcgg     2460

agagaccaga tccctgtctt ctga                                            2484


<210>  82
<211>  1362
<212>  DNA
<213>  Homo sapiens;

<400>  82
atggcgctgg tgcgcgcact cgtctgctgc ctgctgactg cctggcactg ccgctccggc       60

ctcgggctgc ccgtggcgcc cgcaggcggc aggaatcctc ctccggcgat aggacagttt      120

tggcatgtga ctgacttaca cttagaccct acttaccaca tcacagatga ccacacaaaa      180

gtgtgtgctt catctaaagg tgcaaatgcc tccaaccctg gcccttttgg agatgttctg      240

tgtgattctc catatcaact tattttgtca gcatttgatt ttattaaaaa ttctggacaa      300

gaagcatctt tcatgatatg gacaggggat agcccacctc atgttcctgt acctgaactc      360

tcaacagaca ctgttataaa tgtgatcact aatatgacaa ccaccatcca gagtctcttt      420

ccaaatctcc aggttttccc tgcgctgggt aatcatgact attggccaca ggatcaactg      480

cctgtagtca ccagtaaagt gtacaatgca gtagcaaacc tctggaaacc atggctagat      540

gaagaagcta ttagtacttt aaggaaaggt ggtttttatt cacagaaagt tacaactaat      600

ccaaacctta ggatcatcag tctaaacaca aacttgtact acggcccaaa tataatgaca      660

ctgaacaaga ctgacccagc caaccagttt gaatggctag aaagtacatt gaacaactct      720

cagcagaata aggagaaggt gtatatcata gcacatgttc cagtggggta tctgccatct      780

tcacagaaca tcacagcaat gagagaatac tataatgaga aattgataga tatttttcaa      840

aaatacagtg atgtcattgc aggacaattt tatggacaca ctcacagaga cagcattatg      900

gttctttcag ataaaaaagg aagtccagta aattctttgt ttgtggctcc tgctgttaca      960

ccagtgaaga gtgttttaga aaaacagacc aacaatcctg gtatcagact gtttcagtat     1020

gatcctcgtg attataaatt attggatatg ttgcagtatt acttgaatct gacagaggcg     1080

aatctaaagg gagagtccat ctggaagctg gagtatatcc tgacccagac ctacgacatt     1140

gaagatttgc agccggaaag tttatatgga ttagctaaac aatttacaat cctagacagt     1200

aagcagttta taaaatacta caattacttc tttgtgagtt atgacagcag tgtaacatgt     1260

gataagacat gtaaggcctt tcagatttgt gcaattatga atcttgataa tatttcctat     1320

gcagattgcc tcaaacagct ttatataaag cacaattact ag                        1362


<210>  83
<211>  789
<212>  DNA
<213>  Homo sapiens;

<400>  83
atgaagaccc cattcggaaa gacacctggc cagcggtcca gagctgatgc aggccatgct       60

ggagtatctg ccaacatgat gaagaagagg acatcccaca aaaaacatcg gagcagtgtg      120

ggtccgagca aacctgtttc ccagccccgg cggaacatcg taggctgcag gattcagcat      180

gggtggaaag aggggaatgg ccctgttacc cagtggaaag gaaccgttct ggaccaggtg      240

cctgtaaatc cttctttgta tcttataaaa tacgatggat ttgactgtgt ttatggacta      300

gaacttaata aagatgaaag agtttctgcg cttgaagtcc tccctgatag agttgcgaca      360

tctcgaatca gcgatgcaca cttggcagac acaatgattg gcaaagcagt ggaacatatg      420

tttgagacag aggatggttc taaagatgag tggaggggaa tggtcttagc acgtgcacct      480

gtcatgaaca catggtttta cattacctat gagaaagacc ctgtcttgta catgtaccaa      540

ctcttagatg attacaaaga aggcgacctt cgcattatgc ctgattccaa tgattcacct      600

ccagcagaaa gggaaccagg agaagttgtg gacagcctgg taggcaaaca agtggaatat      660

gccaaagaag atggctcgaa aaggactggc atggtcattc atcaagtaga agccaagccc      720

tccgtctatt tcatcaagtt tgatgatgat ttccatattt atgtctacga tttggtgaaa      780

acatcctag                                                              789


<210>  84
<211>  1053
<212>  DNA
<213>  Homo sapiens;

<400>  84
atgaagtgct ccctgcgggt gtggttcctc tccgtggcct tcctgctggt gttcatcatg       60

tccctgctct tcacctactc gcaccacagc atggccacgc tcccctacct ggactcaggg      120

gccctggatg ggacgcaccg ggtgaagctg gtgcccggct atgccggcct gcagcgcctc      180

agcaaggaga ggctctcggg caagagctgt gcctgtcgcc gctgcatggg cgatgccggt      240

gcctccgact ggtttgacag ccactttgac ggtaacattt cccccgtctg gacccgagag      300

aacatggatc ttccaccgga cgtccagagg tggtggatga tgctgcagcc ccagttcaag      360

tcacacaaca ccaatgaggt gctggagaag ctgttccaga tagtgcctgg cgagaacccc      420

taccgcttcc gggaccccca ccagtgccgg cgctgtgccg tggtggggaa ctcgggcaac      480

ctgcggggct ctggctatgg gcaggacgtg gacgggcaca acttcatcat gaggatgaat      540

caggcgccaa ccgtgggctt tgagcaggat gttggcagcc gaaccaccca ccatttcatg      600

taccctgaga gtgccaagaa cctgcccgcc aacgtcagct tcgtgctggt gcccttcaag      660

gtcctggacc ttctgtggat cgccagcgcc ttgtccacgg ggcagatccg attcacctac      720

gccccagtga agtccttcct tcgagtggat aaagaaaagg tccagatcta caacccagcc      780

ttcttcaagt atatccacga caggtggaca gagcatcacg ggcggtaccc ttccacgggg      840

atgctggtgc ttttctttgc cctgcatgtg tgtgatgagg tgaacgtgta cgggttcggg      900

gccgacagcc ggggcaactg gcaccactac tgggagaaca accggtacgc gggcgagttc      960

cggaagactg gcgtgcacga cgcggacttc gaggcccaca tcatcgacat gctggccaag     1020

gccagcaaga tcgaagtcta ccggggcaac tga                                  1053


<210>  85
<211>  2733
<212>  DNA
<213>  Homo sapiens;

<400>  85
atgattgact taagcttcct gactgaagag gaacaagagg ccatcatgaa ggttttgcag       60

cgggatgctg ctctgaagag ggccgaagaa gagagagtca gacatttgcc tgaaaaaatt      120

aaggatgacc agcagctgaa gaatatgagt ggccaatggt tttatgaagc caaggcaaaa      180

aggcacaggg acaaaatcca tggcgcagat atcatcagag catctatgag aaagaagagg      240

ccccagatag cagctgagca gagtaaagac agagaaaatg gggcaaagga aagctgggtg      300

aataatgtca acaaagatgc tttccttcct ccagagctgg ctggcgttgt agaagagcca      360

gaagaagatg cagcaccagc aagcccgagt tccagtgtgg taaatccagc ttccagtgtg      420

attgatatgt cccaggaaaa cacaaggaaa ccaaatgtgt ctccagagaa gaggaagaat      480

ccgtttaata gctccaagtt gccagaaggt cactcatcac aacaaactaa aaatgaacag      540

tcaaaaaatg gaagaactgg tttatttcag acttcaaaag aggatgaatt gtcagagtca      600

aaagaaaagt caactgtcgc agatacttca atccaaaagt tagagaaatc aaagcagact      660

ttgccaggcc tttcaaatgg gtcccaaatc aaggctccaa tccccaaagc caggaagatg      720

atctacaaat caactgattt aaacaaagat gataaccagt cttttcctag acaaaggaca      780

gactccctga aagcgagagg ggctccgaga gggatcctca agcgcaactc cagttccagt      840

agcacagact cagaaaccct tcgttataat cacaactttg aacccaaaag caaaattgtg      900

tcacctggcc taaccatcca tgagagaatt tctgagaagg agcattcttt agaagacaac      960

tcttccccaa actccctgga gccattaaag catgtgagat tctctgcagt gaaggatgag     1020

cttccacaga gtcctgggct aatccatggt cgggaagtag gagaatttag tgttttagaa     1080

tctgacagat tgaaaaatgg aatggaagat gcaggggaca cagaagagtt tcagagtgac     1140

cctaagcctt ctcaatacag aaagccttcg ctttttcatc aatcaacctc aagcccatat     1200

gtatcaaaaa gtgaaacaca tcagccaatg acttctggtt cttttccaat taatgggctg     1260

cattctcatt cagaagtttt aactgcaaga ccacagtcta tggagaattc accaaccatc     1320

aatgaaccca aagataaatc atcagaatta acaaggcttg aatctgtatt acccagaagc     1380

cctgctgatg aactgtctca ttgtgttgag cctgagccat ctcaggtgcc aggtggcagt     1440

tctagagacc gtcagcaagg ttcagaagaa gaacccagtc ctgttttgaa aactttggaa     1500

aggagtgccg ctaggaaaat gccttccaaa agtctagaag acatttcatc agattcatca     1560

aatcaagcaa aagtagataa tcagccagaa gaattagtgc gtagtgctga agatgatgag     1620

aaaccagatc agaagccagt tacaaatgaa tgcgtaccaa gaatttccac agtgcctaca     1680

caacctgata atccattttc tcaccctgac aaactcaaaa ggatgagcaa gtctgttcca     1740

gcatttctcc aagatgaggt gagtggcagt gtgatgagtg tttatagtgg agactttggc     1800

aatctggaag ttaaaggaaa tattcagttt gcaattgaat atgtggagtc actgaaggag     1860

ttgcatgttt ttgtggccca gtgtaaggac ttagcagcag cggatgtaaa aaaacagcgt     1920

tcagacccat atgtaaaggc ctatttgcta ccagacaaag gcaaaatggg caagaagaaa     1980

acactcgtag tgaagaaaac cttgaatcct gtgtataacg aaatactgcg gtataaaatt     2040

gaaaaacaaa tcttaaagac acagaaattg aacctgtcca tttggcatcg ggatacattt     2100

aagcgcaata gtttcctagg ggaggtggaa cttgatttgg aaacatggga ctgggataac     2160

aaacagaata aacaattgag atggtaccct ctgaagcgga agacagcacc agttgccctt     2220

gaagcagaaa acagaggtga aatgaaacta gctctccagt atgtcccaga gccagtccct     2280

ggtaaaaagc ttcctacaac tggagaagtg cacatctggg tgaaggaatg ccttgatcta     2340

ccactgctaa ggggaagtca tctaaattct tttgttaaat gtaccatcct tccagataca     2400

agtaggaaaa gtcgccagaa gacaagagct gtagggaaaa ccaccaaccc tatcttcaac     2460

cacactatgg tgtatgatgg gttcaggcct gaagatctga tggaagcctg tgtagagctt     2520

actgtctggg accattacaa attaaccaac caatttttgg gaggtcttcg tattggcttt     2580

ggaacaggta aaagttatgg gactgaagtg gactggatgg actctacttc agaggaagtt     2640

gctctctggg agaagatggt aaactccccc aatacttgga ttgaagcaac actgcctctc     2700

agaatgcttt tgattgccaa gatttccaaa tga                                  2733


<210>  86
<211>  2556
<212>  DNA
<213>  Homo sapiens;

<400>  86
atgacttccc attatgtgat tgccatcttt gccctgatga gctcctgttt agccactgca       60

ggtccagagc ctggtgcact gtgtgaactg tcacctgtca gtgcctccca tcctgtccag      120

gccttgatgg agagcttcac tgttttgtca ggctgtgcca gcagaggcac aactgggctg      180

ccacaggagg tgcatgtcct gaatctccgc actgcaggcc aggggcctgg ccagctacag      240

agagaggtca cacttcacct gaatcccatc tcctcagtcc acatccacca caagtctgtt      300

gtgttcctgc tcaactcccc acaccccctg gtgtggcatc tgaagacaga gagacttgcc      360

actggggtct ccagactgtt tttggtgtct gagggttctg tggtccagtt ttcatcagca      420

aacttctcct tgacagcaga aacagaagaa aggaacttcc cccatggaaa tgaacatctg      480

ttaaattggg cccgaaaaga gtatggagca gttacttcat tcaccgaact caagatagca      540

agaaacattt atattaaagt gggggaagat caagtgttcc ctccaaagtg caacataggg      600

aagaattttc tctcactcaa ttaccttgct gagtaccttc aacccaaagc agcagaaggg      660

tgtgtgatgt ccagccagcc ccagaatgag gaagtacaca tcatcgagct aatcaccccc      720

aactctaacc cctacagtgc tttccaggtg gatataacaa ttgatataag accttctcaa      780

gaggatcttg aagtggtcaa aaatctcatc ctgatcttga agtgcaaaaa gtctgtcaac      840

tgggtgatca aatcttttga tgttaaggga agcctgaaaa ttattgctcc taacagtatt      900

ggctttggaa aagagagtga aagatctatg acaatgacca aatcaataag agatgacatt      960

ccttcaaccc aagggaatct ggtgaagtgg gctttggaca atggctatag tccaataact     1020

tcatacacaa tggctcctgt ggctaataga tttcatcttc ggcttgaaaa taatgcagag     1080

gagatgggag atgaggaagt ccacactatt cctcctgagc tacggatcct gctggaccct     1140

ggtgccctgc ctgccctgca gaacccgccc atccggggag gggaaggcca aaatggaggc     1200

cttccgtttc ctttcccaga tatttccagg agagtctgga atgaagaggg agaagatggg     1260

ctccctcggc caaaggaccc tgtcattccc agcatacaac tgtttcctgg tctcagagag     1320

ccagaagagg tgcaagggag cgtggatatt gccctgtctg tcaaatgtga caatgagaag     1380

atgatcgtgg ctgtagaaaa agattctttt caggccagtg gctactcggg gatggacgtc     1440

accctgttgg atcctacctg caaggccaag atgaatggca cacactttgt tttggagtct     1500

cctctgaatg gctgcggtac tcggccccgg tggtcagccc ttgatggtgt ggtctactat     1560

aactccattg tgatacaggt tccagccctt ggggacagta gtggttggcc agatggttat     1620

gaagatctgg agtcaggtga taatggattt ccgggagata tggatgaagg agatgcttcc     1680

ctgttcaccc gacctgaaat cgtggtgttt aattgcagcc ttcagcaggt gaggaacccc     1740

agcagcttcc aggaacagcc ccacggaaac atcaccttca acatggagct atacaacact     1800

gacctctttt tggtgccctc ccagggcgtc ttctctgtgc cagagaatgg acacgtttat     1860

gttgaggtat ctgttactaa ggctgaacaa gaactgggat ttgccatcca aacgtgcttt     1920

atctctccat attcgaaccc tgataggatg tctcattaca ccattattga gaatatttgt     1980

cctaaagatg aatctgtgaa attctacagt cccaagagag tgcactttcc tatcccgcaa     2040

gctgacatgg ataagaagcg attcagcttt gtcttcaagc ctgtcttcaa cacctcactg     2100

ctctttctac agtgtgagct gacgctgtgt acgaagatgg agaagcaccc ccagaagttg     2160

cctaagtgtg tgcctcctga cgaagcctgc acctcgctgg acgcctcgat aatctgggcc     2220

atgatgcaga ataagaagac gttcactaag ccccttgctg tgatccacca tgaagcagaa     2280

tctaaagaaa aaggtccaag catgaaggaa ccaaatccaa tttctccacc aattttccat     2340

ggtctggaca ccctaaccgt gatgggcatt gcgtttgcag cctttgtgat cggagcactc     2400

ctgacggggg ccttgtggta catctattct cacacagggg agacagcagg aaggcagcaa     2460

gtccccacct ccccgccagc ctcggaaaac agcagtgctg cccacagcat cggcagcacg     2520

cagagcacgc cttgctccag cagcagcacg gcctag                               2556


<210>  87
<211>  2319
<212>  DNA
<213>  Homo sapiens;

<400>  87
atgtatccgc agggcagaca tccggctccc catcaacccg ggcagccggg atttaaattc       60

acggtggctg agtcttgtga caggatcaaa gacgaattcc agttcctgca agctcagtat      120

cacagcctca aagtggagta cgacaagctg gcaaacgaga agacggagat gcagcgccat      180

tatgtgatgt actatgagat gtcctatggc ttgaacattg aaatgcacaa gcagacagag      240

attgcgaaga gactgaacac aattttagca cagatcatgc ctttcctgtc acaagagcac      300

cagcagcagg tggcgcaggc agtggagcgc gccaagcagg tcaccatgac ggagctgaac      360

gccatcatcg ggcagcagca gctccaggcg cagcacctct cccatgccac acacggcccc      420

ccggtccagt tgccacccca cccgtcaggt ctccagcctc caggaatccc cccagtgaca      480

gggagcagct ccgggctgct ggcactgggc gccctgggca gccaggccca tctgacggtg      540

aaggatgaga agaaccacca tgaactcgat cacagagaga gagaatccag tgcgaataac      600

tctgtgtcac cctcggaaag cctccgggcc agtgagaagc accggggctc tgcggactac      660

agcatggaag ccaagaagcg gaaggcggag gagaaggaca gcttgagccg atacgacagt      720

gatggagaca agagtgatga tctggtggtg gatgtttcca atgaggaccc cgcaacgccc      780

cgggtcagcc cggcacactc ccctcctgaa aatgggctgg acaaggcccg tagcctgaaa      840

aaagatgccc ccaccagccc tgcctcggtg gcctcttcca gtagcacacc ttcctccaag      900

accaaagacc ttggtcataa cgacaaatcc tccacccctg ggctcaagtc caacacacca      960

accccaagga acgacgcccc aactccaggc accagcacga ccccagggct caggtcgatg     1020

ccgggtaaac ctccgggcat ggacccgata ggtataatgg cctcggctct gcgcacgccc     1080

atctccatca ccagctccta tgcggcgccc ttcgccatga tgagccacca tgagatgaac     1140

ggctccctca ccagtcctgg cgcctacgcc ggcctccaca acatcccacc ccagatgagc     1200

gccgccgccg ctgctgcagc cgctgcctat ggccgatcgc caatggtgag ctttggagct     1260

gttggttttg accctcaccc cccgatgcgg gccacaggcc tcccctcaag cctggcctcc     1320

attcctggag gaaaaccagc gtactcattc catgtgagtg ctgatgggca gatgcagccc     1380

gtgcccttcc cccacgacgc cctggcaggc cccggcatcc cgaggcacgc ccggcagatc     1440

aacacactca gccacgggga ggtggtgtgt gccgtgacca tcagcaaccc cacgaggcac     1500

gtctacacag gtggcaaggg ctgcgtgaag atctgggaca tcagccagcc aggcagcaag     1560

agccccatct cccagctgga ctgcctgaac agggacaatt acatccgctc ctgcaagctg     1620

ctccctgatg ggcgcacgct catcgtgggc ggcgaggcca gcacgctcac catctgggac     1680

ctggcctcgc ccacgccccg catcaaggcc gagctgacgt cctcggctcc cgcctgttat     1740

gccctggcca ttagccctga cgccaaagtc tgcttctcct gctgcagcga tgggaacatt     1800

gctgtctggg acctgcacaa ccagaccctg gtcaggcagt tccagggcca cacagatggg     1860

gccagctgca tagacatctc ccatgatggc accaaactgt ggacaggggg cctggacaac     1920

acggtgcgct cctgggacct gcgggagggc cgacagctac agcagcatga cttcacttcc     1980

cagatcttct cgctgggcta ctgccccact ggggagtggc tggctgtggg catggagagc     2040

agcaacgtgg aggtgctgca ccacaccaag cctgacaagt accagctgca cctgcacgag     2100

agctgcgtgc tctccctcaa gttcgcctac tgcggcaagt ggttcgtgag cactgggaaa     2160

gataaccttc tcaacgcctg gaggacgcct tatggagcca gcatattcca gtctaaagaa     2220

tcctcgtctg tcttgagttg tgacatttca gcggatgaca aatacattgt aacaggctct     2280

ggtgacaaga aggccacagt ttatgaggtc atctactaa                            2319


<210>  88
<211>  2577
<212>  DNA
<213>  Homo sapiens;

<400>  88
atgggagacc acctggacct tctcctagga gtggtgctca tggccggtcc tgtgtttgga       60

attccttcct gctcctttga tggccgaata gccttttatc gtttctgcaa cctcacccag      120

gtcccccagg tcctcaacac cactgagagg ctcctgctga gcttcaacta tatcaggaca      180

gtcactgctt catccttccc ctttctggaa cagctgcagc tgctggagct cgggagccag      240

tataccccct tgactattga caaggaggcc ttcagaaacc tgcccaacct tagaatcttg      300

gacctgggaa gtagtaagat atacttcttg catccagatg cttttcaggg actgttccat      360

ctgtttgaac ttagactgta tttctgtggt ctctctgatg ctgtattgaa agatggttat      420

ttcagaaatt taaaggcttt aactcgcttg gatctatcca aaaatcagat tcgtagcctt      480

taccttcatc cttcatttgg gaagttgaat tccttaaagt ccatagattt ttcctccaac      540

caaatattcc ttgtatgtga acatgagctc gagcccctac aagggaaaac gctctccttt      600

tttagcctcg cagctaatag cttgtatagc agagtctcag tggactgggg aaaatgtatg      660

aacccattca gaaacatggt gctggagata ctagatgttt ctggaaatgg ctggacagtg      720

gacatcacag gaaactttag caatgccatc agcaaaagcc aggccttctc tttgattctt      780

gcccaccaca tcatgggtgc cgggtttggc ttccataaca tcaaagatcc tgaccagaac      840

acatttgctg gcctggccag aagttcagtg agacacctgg atctttcaca tgggtttgtc      900

ttctccctga actcacgagt ctttgagaca ctcaaggatt tgaaggttct gaaccttgcc      960

tacaacaaga taaataagat tgcagatgaa gcattttacg gacttgacaa cctccaagtt     1020

ctcaatttgt catataacct tctgggggaa ctttacagtt cgaatttcta tggactacct     1080

aaggtagcct acattgattt gcaaaagaat cacattgcaa taattcaaga ccaaacattc     1140

aaattcctgg aaaaattaca gaccttggat ctccgagaca atgctcttac aaccattcat     1200

tttattccaa gcatacccga tatcttcttg agtggcaata aactagtgac tttgccaaag     1260

atcaacctta cagcgaacct catccactta tcagaaaaca ggctagaaaa tctagatatt     1320

ctctactttc tcctacgggt acctcatctc cagattctca ttttaaatca aaatcgcttc     1380

tcctcctgta gtggagatca aaccccttca gagaatccca gcttagaaca gcttttcctt     1440

ggagaaaata tgttgcaact tgcctgggaa actgagctct gttgggatgt ttttgaggga     1500

ctttctcatc ttcaagttct gtatttgaat cataactatc ttaattccct tccaccagga     1560

gtatttagcc atctgactgc attaagggga ctaagcctca actccaacag gctgacagtt     1620

ctttctcaca atgatttacc tgctaattta gagatcctgg acatatccag gaaccagctc     1680

ctagctccta atcctgatgt atttgtatca cttagtgtct tggatataac tcataacaag     1740

ttcatttgtg aatgtgaact tagcactttt atcaattggc ttaatcacac caatgtcact     1800

atagctgggc ctcctgcaga catatattgt gtgtaccctg actcgttctc tggggtttcc     1860

ctcttctctc tttccacgga aggttgtgat gaagaggaag tcttaaagtc cctaaagttc     1920

tcccttttca ttgtatgcac tgtcactctg actctgttcc tcatgaccat cctcacagtc     1980

acaaagttcc ggggcttctg ttttatctgt tataagacag cccagagact ggtgttcaag     2040

gaccatcccc agggcacaga acctgatatg tacaaatatg atgcctattt gtgcttcagc     2100

agcaaagact tcacatgggt gcagaatgct ttgctcaaac acctggacac tcaatacagt     2160

gaccaaaaca gattcaacct gtgctttgaa gaaagagact ttgtcccagg agaaaaccgc     2220

attgccaata tccaggatgc catctggaac agtagaaaga tcgtttgtct tgtgagcaga     2280

cacttcctta gagatggctg gtgccttgaa gccttcagtt atgcccaggg caggtgctta     2340

tctgacctta acagtgctct catcatggtg gtggttgggt ccttgtccca gtaccagttg     2400

atgaaacatc aatccatcag aggctttgta cagaaacagc agtatttgag gtggcctgag     2460

gatctccagg atgttggctg gtttcttcat aaactctctc aacagatact aaagaaagaa     2520

aaagaaaaga agaaagacaa taacattccg ttgcaaactg tagcaaccat ctcctaa        2577


<210>  89
<211>  975
<212>  DNA
<213>  Homo sapiens;

<400>  89
atggcggccg cggctccagg gaacggccgc gcatcggcgc cccggctgct tctgctcttt       60

ctggttccgc tgctgtgggc cccggctgcg gtccgggccg gcccagatga agaccttagc      120

caccggaaca aagaaccgcc ggcgccggcc cagcagctgc agccgcagcc tgtggctgtg      180

cagggccccg agccggcccg ggtcgagaaa atatttacac cagcagctcc agttcatacc      240

aataaagaag atcctgctac ccaaactaat ttgggattta tccatgcatt tgtcgctgcc      300

atatcagtta ttattgtatc tgaattgggt gataagacat tttttatagc agccatcatg      360

gcaatgcgct ataaccgcct gaccgtgctg gctggtgcaa tgcttgcctt gggactaatg      420

acatgcttgt cagttttgtt tggctatgcc accacagtca tccccagggt ctatacatac      480

tatgtttcaa ctgtattatt tgccattttt ggcattagaa tgcttcggga aggcttaaag      540

atgagccctg atgagggtca agaggaactg gaagaagttc aagctgaatt aaagaagaaa      600

gatgaagaat ttcaacgaac caaactttta aatggaccgg gagatgttga aacgggtaca      660

agcataacag tacctcagaa aaagtggttg cattttattt cacccatttt tgttcaagct      720

cttacattaa cattcttagc agaatggggt gatcgctctc aactaactac aattgtattg      780

gcagctagag aggaccccta tggtgtagcc gtgggtggaa ctgtggggca ctgcctgtgc      840

acgggattgg cagtaattgg aggaagaatg atagcacaga aaatctctgt cagaactgtg      900

acaatcatag gaggcatcgt ttttttggcg tttgcatttt ctgcactatt tataagccct      960

gattctggtt tttaa                                                       975


<210>  90
<211>  510
<212>  DNA
<213>  Homo sapiens;

<400>  90
atggccccgc cctgggtgcc cgccatgggc ttcacgctgg cgcccagcct ggggtgcttc       60

gtgggctccc gctttgtcca cggcgagggt ctccgctggt acgccggcct gcagaagccc      120

tcgtggcacc cgccccactg ggtgctgggc cctgtctggg gcacgctcta ctcagccatg      180

gggtacggct cctacctggt ctggaaagag ctgggaggct tcacagagaa ggctgtggtt      240

cccctgggcc tctacactgg gcagctggcc ctgaactggg catggccccc catcttcttt      300

ggtgcccgac aaatgggctg ggccttggtg gatctcctgc tggtcagtgg ggcggcggca      360

gccactaccg tggcctggta ccaggtgagc ccgctggccg cccgcctgct ctacccctac      420

ctggcctggc tggccttcac gaccacactc aactactgcg tatggcggga caaccatggc      480

tggcgtgggg gacggcggct gccagagtga                                       510


<210>  91
<211>  10302
<212>  DNA
<213>  Homo sapiens;

<400>  91
atggccaagt atggagaaca tgaagccagt cctgacaatg ggcagaacga attcagtgat       60

atcattaagt ccagatctga tgaacacaat gacgtacaga agaaaacctt taccaaatgg      120

ataaatgctc gattttcaaa gagtgggaaa ccacccatca atgatatgtt cacagacctc      180

aaagatggaa ggaagctatt ggatcttcta gaaggcctca caggaacatc actgccaaag      240

gaacgtggtt ccacaagggt acatgcctta aataacgtca acagagtgct gcaggtttta      300

catcagaaca atgtggaatt agtgaatata gggggaactg acattgtgga tggaaatcac      360

aaactgactt tggggttact ttggagcatc attttgcact ggcaggtgaa agatgtcatg      420

aaggatgtca tgtcggacct gcagcagacg aacagtgaga agatcctgct cagctgggtg      480

cgtcagacca ccaggcccta cagccaagtc aacgtcctca acttcaccac cagctggaca      540

gatggactcg cctttaatgc tgtcctccac cgacataaac ctgatctctt cagctgggat      600

aaagttgtca aaatgtcacc aattgagaga cttgaacatg ccttcagcaa ggctcaaact      660

tatttgggaa ttgaaaagct gttagatcct gaagatgttg ccgttcagct tcctgacaag      720

aaatccataa ttatgtattt aacatctttg tttgaggtgc tacctcagca agtcaccata      780

gacgccatcc gtgaggtaga gacactccca aggaaatata aaaaagaatg tgaagaagag      840

gcaattaata tacagagtac agcgcctgag gaggagcatg agagtccccg agctgaaact      900

cccagcactg tcactgaggt tgacatggat ctggacagct atcagattgc gttggaggaa      960

gtgctgacct ggttgctttc tgctgaggac actttccagg agcaggatga tatttctgat     1020

gatgttgaag aagtcaaaga ccagtttgca acccatgaag cttttatgat ggaactgact     1080

gcacaccaga gcagtgtggg cagcgtcctg caggcaggca accaactgat aacacaagga     1140

actctgtcag acgaagaaga atttgagatt caggaacaga tgaccctgct gaatgctaga     1200

tgggaggctc ttagggtgga gagtatggac agacagtccc ggctgcacga tgtgctgatg     1260

gaactgcaga agaagcaact gcagcagctc tccgcctggt taacactcac agaggagcgc     1320

attcagaaga tggaaacttg ccccctggat gatgatgtaa aatctctaca aaagctgcta     1380

gaagaacata aaagtttgca aagtgatctt gaggctgaac aggtgaaagt aaattcacta     1440

actcacatgg tggtcattgt tgatgaaaac agtggtgaga gtgctacagc tatcctagaa     1500

gaccagttac agaaacttgg tgagcgctgg acagcagtat gccgttggac tgaagaacgc     1560

tggaataggt tacaagaaat caatatattg tggcaggaat tattggaaga acagtgcttg     1620

ttgaaagctt ggttaaccga aaaagaagag gctttaaata aagtccagac aagcaacttc     1680

aaagaccaaa aggaactaag tgtcagtgtt cgacgtctgg ctattttgaa ggaagacatg     1740

gaaatgaagc gtcaaacatt ggatcagctg agtgagattg gccaggatgt gggacaatta     1800

cttgataatt ccaaggcatc taagaagatc aacagtgact cagaggaact gactcaaaga     1860

tgggattctt tggttcagag actagaagat tcctccaacc aggtgactca ggctgtagca     1920

aagctgggga tgtctcagat tcctcagaag gaccttttgg agactgttcg tgtaagagaa     1980

caagcaatta caaaaaaatc taagcaggaa ctgcctcctc ctcctccccc aaagaagaga     2040

cagatccatg tggatattga agctaagaaa aagtttgatg ctataagtgc agagctgttg     2100

aactggattt tgaaatggaa aactgccatt cagaccacag agataaaaga gtatatgaag     2160

atgcaagaca cttccgaaat gaaaaagaag ttgaaggcat tagaaaaaga acagagagaa     2220

agaatcccca gagcagatga attaaaccaa actggacaaa tccttgtgga gcaaatggga     2280

aaagaaggcc ttcctactga agaaataaaa aatgttctgg agaaggtttc atcagaatgg     2340

aagaatgtat ctcaacattt ggaagatcta gaaagaaaga ttcagctaca ggaagatata     2400

aatgcttatt tcaagcagct tgatgagctt gaaaaggtca tcaagacaaa ggaggagtgg     2460

gtaaaacaca cttccatttc tgaatcttcc cggcagtcct tgccaagctt gaaggattcc     2520

tgtcagcggg aattgacaaa tcttcttggc cttcacccca aaattgaaat ggctcgtgca     2580

agctgctcgg ccctgatgtc tcagccttct gccccagatt ttgtccagcg gggcttcgat     2640

agctttctgg gccgctacca agctgtacaa gaggctgtag aggatcgtca acaacatcta     2700

gagaatgaac tgaagggcca acctggacat gcatatctgg aaacattgaa aacactgaaa     2760

gatgtgctaa atgattcaga aaataaggcc caggtgtctc tgaatgtcct taatgatctt     2820

gccaaggtgg agaaggccct gcaagaaaaa aagacccttg atgaaatcct tgagaatcag     2880

aaacctgcat tacataaact tgcagaagaa acaaaggctc tggagaaaaa tgttcatcct     2940

gatgtagaaa aattatataa gcaagaattt gatgatgtgc aaggaaagtg gaacaagcta     3000

aaggtcttgg tttccaaaga tctacatttg cttgaggaaa ttgctctcac actcagagct     3060

tttgaggccg attcaacagt cattgagaag tggatggatg gcgtgaaaga cttcttaatg     3120

aaacagcagg ctgcccaagg agacgacgca ggtctacaga ggcagttaga ccagtgctct     3180

gcatttgtta atgaaataga aacaattgaa tcatctctga aaaacatgaa ggaaatagag     3240

actaatcttc gaagtggtcc agttgctgga ataaaaactt gggtgcagac aagactaggt     3300

gactaccaaa ctcaactgga gaaacttagc aaggagatcg ctactcaaaa aagtaggttg     3360

tctgaaagtc aagaaaaagc tgcgaacctg aagaaagact tggcagagat gcaggaatgg     3420

atgacccagg ccgaggaaga atatttggag cgggattttg agtacaagtc accagaagag     3480

cttgagagtg ctgtggaaga gatgaagagg gcaaaagagg atgtgttgca gaaggaggtg     3540

agagtgaaga ttctcaagga caacatcaag ttattagctg ccaaggtgcc ctctggtggc     3600

caggagttga cgtctgagct gaatgttgtg ctggagaatt accaacttct ttgtaataga     3660

attcgaggaa agtgccacac gctagaggag gtctggtctt gttggattga actgcttcac     3720

tatttggatc ttgaaactac ctggttaaac actttggaag agcggatgaa gagcacagag     3780

gtcctgcctg agaagacgga tgctgtcaac gaagccctgg agtctctgga atctgttctg     3840

cgccacccgg cagataatcg cacccagatt cgagagcttg gccagactct gattgatggg     3900

gggatcctgg atgatataat cagtgagaaa ctggaggctt tcaacagccg atatgaagat     3960

ctaagtcacc tggcagagag caagcagatt tctttggaaa agcaactcca ggtgctgcgg     4020

gaaactgacc agatgcttca agtcttgcaa gagagcttgg gggagctgga caaacagctc     4080

accacatacc tgactgacag gatagatgct ttccaagttc cacaggaagc tcagaaaatc     4140

caagcagaga tctcagccca tgagctaacc ctagaggagt tgagaagaaa tatgcgttct     4200

cagcccctga cctccccaga gagtaggact gccagaggag gaagtcagat ggatgtgcta     4260

cagaggaaac tccgagaggt gtccacaaag ttccagcttt tccagaagcc agctaacttc     4320

gagcagcgca tgctggactg caagcgtgtg ctggatggcg tgaaagcaga acttcacgtt     4380

ctggatgtga aggacgtaga ccctgacgtc atacagacgc acctggacaa gtgtatgaaa     4440

ctgtataaaa ctttgagtga agtcaaactt gaagtggaaa ctgtgattaa aacaggaaga     4500

catattgtcc agaaacagca aacggacaac ccaaaaggga tggatgagca gctgacttcc     4560

ctgaaggttc tttacaatga cctgggcgca caggtgacag aaggaaaaca ggatctggaa     4620

agagcatcac agttggcccg gaaaatgaag aaagaggctg cttctctctc tgaatggctt     4680

tctgctactg aaactgaatt ggtacagaag tccacttcag aaggtctgct tggtgacttg     4740

gatacagaaa tttcctgggc taaaaatgtt ctgaaggatc tggaaaagag aaaagctgat     4800

ttaaatacca tcacagagag tagtgctgcc ctgcaaaact tgattgaggg cagtgagcct     4860

attttagaag agaggctctg cgtccttaac gctgggtgga gccgagttcg tacctggact     4920

gaagattggt gcaatacctt gatgaaccat cagaaccagc tagaaatatt tgatgggaac     4980

gtggctcaca taagtacctg gctttatcaa gctgaagctc tattggatga aattgaaaag     5040

aaaccaacaa gtaaacagga agaaattgtg aagcgtttag tatctgagct ggatgatgcc     5100

aacctccagg ttgaaaatgt ccgcgatcaa gcccttattt tgatgaatgc ccgtggaagc     5160

tcaagcaggg agcttgtaga accaaagtta gctgagctga ataggaactt tgaaaaggtg     5220

tctcaacata tcaaaagtgc caaattgcta attgctcagg aaccattata ccaatgtttg     5280

gtcaccactg aaacatttga aactggtgtg cctttctctg acttggaaaa attagaaaat     5340

gacatagaaa atatgttaaa atttgtggaa aaacacttgg aatccagtga tgaagatgaa     5400

aagatggatg aggagagtgc ccagattgag gaagttctac aaagaggaga agaaatgtta     5460

catcaaccta tggaagataa taaaaaagaa aagatccgtt tgcaattatt acttttgcat     5520

actagataca acaaaattaa ggcaatccct attcaacaga ggaaaatggg tcaacttgct     5580

tctggaatta gatcatcact tcttcctaca gattatctgg ttgaaattaa caaaatttta     5640

ctttgcatgg atgatgttga attatcgctt aatgttccag agctcaacac tgctatttac     5700

gaagacttct cttttcagga agactctctg aagaatatca aagaccaact ggacaaactt     5760

ggagagcaga ttgcagtcat tcatgaaaaa cagccagatg tcatccttga agcctctgga     5820

cctgaagcca ttcagatcag agatacactt actcagctga atgcaaaatg ggacagaatt     5880

aatagaatgt acagtgatcg gaaaggttgt tttgacaggg caatggaaga atggagacag     5940

ttccattgtg accttaatga cctcacacag tggataacag aggctgaaga attactggtt     6000

gatacctgtg ctccaggtgg cagcctggac ttagagaaag ccaggataca tcagcaggaa     6060

cttgaggtgg gcatcagcag ccaccagccc agttttgcag cactaaaccg aactggggat     6120

gggattgtgc agaaactctc ccaggcagat ggaagcttct tgaaagaaaa actggcaggt     6180

ttaaaccaac gctgggatgc aattgttgca gaagtgaagg ataggcagcc aaggctaaaa     6240

ggagaaagta agcaggtgat gaagtacagg catcagctag atgagattat ctgttggtta     6300

acaaaggctg agcatgctat gcaaaagaga tcaaccaccg aattgggaga aaacctgcaa     6360

gaattaagag acttaactca agaaatggaa gtacatgctg aaaaactcaa atggctgaat     6420

agaactgaat tggagatgct ttcagataaa agtctgagtt tacctgaaag ggataaaatt     6480

tcagaaagct taaggactgt aaatatgaca tggaataaga tttgcagaga ggtgcctacc     6540

accctgaagg aatgcatcca ggagcccagt tctgtttcac agacaaggat tgctgctcat     6600

cctaatgtcc aaaaggtggt gctagtatca tctgcgtcag atattcctgt tcagtctcat     6660

cgtacttcgg aaatttcaat tcctgctgat cttgataaaa ctataacaga actagccgac     6720

tggctggtat taatcgacca gatgctgaag tccaacattg tcactgttgg ggatgtagaa     6780

gagatcaata agaccgtttc ccgaatgaaa attacaaagg ctgacttaga acagcgccat     6840

cctcagctgg attatgtttt tacattggca cagaatttga aaaataaagc ttccagttca     6900

gatatgagaa cagcaattac agaaaaattg gaaagggtca agaaccagtg ggatggcacc     6960

cagcatggcg ttgagctaag acagcagcag cttgaggaca tgattattga cagtcttcag     7020

tgggatgacc atagggagga gactgaagaa ctgatgagaa aatatgaggc tcgactctat     7080

attcttcagc aagcccgacg ggatccactc accaaacaaa tttctgataa ccaaatactg     7140

cttcaagaac tgggtcctgg agatggtatc gtcatggcgt tcgataacgt cctgcagaaa     7200

ctcctggagg aatatgggag tgatgacaca aggaatgtga aagaaaccac agagtactta     7260

aaaacatcat ggatcaatct caaacaaagt attgctgaca gacagaacgc cttggaggct     7320

gagtggagga cggtgcaggc ctctcgcaga gatctggaaa acttcctgaa gtggatccaa     7380

gaagcagaga ccacagtgaa tgtgcttgtg gatgcctctc atcgggagaa tgctcttcag     7440

gatagtatct tggccaggga actcaaacag cagatgcagg acatccaggc agaaattgat     7500

gcccacaatg acatatttaa aagcattgac ggaaacaggc agaagatggt aaaagctttg     7560

ggaaattctg aagaggctac tatgcttcaa catcgactgg atgatatgaa ccaaagatgg     7620

aatgacttaa aagcaaaatc tgctagcatc agggcccatt tggaggccag cgctgagaag     7680

tggaacaggt tgctgatgtc cttagaagaa ctgatcaaat ggctgaatat gaaagatgaa     7740

gagcttaaga aacaaatgcc tattggagga gatgttccag ccttacagct ccagtatgac     7800

cattgtaagg ccctgagacg ggagttaaag gagaaagaat attctgtcct gaatgctgtc     7860

gaccaggccc gagttttctt ggctgatcag ccaattgagg cccctgaaga gccaagaaga     7920

aacctacaat caaaaacaga attaactcct gaggagagag cccaaaagat tgccaaagcc     7980

atgcgcaaac agtcttctga agtcaaagaa aaatgggaaa gtctaaatgc tgtaactagc     8040

aattggcaaa agcaagtgga caaggcattg gagaaactca gagacctgca gggagctatg     8100

gatgacctgg acgctgacat gaaggaggca gagtccgtgc ggaatggctg gaagcccgtg     8160

ggagacttac tcattgactc gctgcaggat cacattgaaa aaatcatggc atttagagaa     8220

gaaattgcac caatcaactt taaagttaaa acggtgaatg atttatccag tcagctgtct     8280

ccacttgacc tgcatccctc tctaaagatg tctcgccagc tagatgacct taatatgcga     8340

tggaaacttt tacaggtttc tgtggatgat cgccttaaac agcttcagga agcccacaga     8400

gattttggac catcctctca gcattttctc tctacgtcag tccagctgcc gtggcaaaga     8460

tccatttcac ataataaagt gccctattac atcaaccatc aaacacagac cacctgttgg     8520

gaccatccta aaatgaccga actctttcaa tcccttgctg acctgaataa tgtacgtttt     8580

tctgcctacc gtacagcaat caaaatccga agactacaaa aagcactatg tttggatctc     8640

ttagagttga gtacaacaaa tgaaattttc aaacagcaca agttgaacca aaatgaccag     8700

ctcctcagtg ttccagatgt catcaactgt ctgacaacaa cttatgatgg acttgagcaa     8760

atgcataagg acctggtcaa cgttccactc tgtgttgata tgtgtctcaa ttggttgctc     8820

aatgtctatg acacgggtcg aactggaaaa attagagtgc agagtctgaa gattggatta     8880

atgtctctct ccaaaggtct cttggaagaa aaatacagat atctctttaa ggaagttgca     8940

gggccaacag aaatgtgtga ccagaggcag ctgggcctgt tacttcatga tgccatccag     9000

atcccccggc agctaggtga agtagcagct tttggaggca gtaatattga gcctagtgtt     9060

cgcagctgct tccaacagaa taacaataaa ccagaaataa gtgtgaaaga gtttatagat     9120

tggatgcatt tggaaccaca gtccatggtt tggctcccag ttttacatcg agtggcagca     9180

gcggagactg caaaacatca ggccaaatgc aacatctgta aagaatgtcc aattgtcggg     9240

ttcaggtata gaagccttaa gcattttaac tatgatgtct gccagagttg tttcttttcg     9300

ggtcgaacag caaaaggtca caaattacat tacccaatgg tggaatattg tatacctaca     9360

acatctgggg aagatgtacg agacttcaca aaggtactta agaacaagtt caggtcgaag     9420

aagtactttg ccaaacaccc tcgacttggt tacctgcctg tccagacagt tcttgaaggt     9480

gacaacttag agactcctat cacactcatc agtatgtggc cagagcacta tgacccctca     9540

caatctcctc aactgtttca tgatgacacc cattcaagaa tagaacaata tgccacacga     9600

ctggcccaga tggaaaggac taatgggtct tttctcactg atagcagctc caccacagga     9660

agtgtggaag acgagcacgc cctcatccag cagtattgcc aaacactcgg aggagagtcc     9720

ccagtgagcc agccgcagag cccagctcag atcctgaagt cagtagagag ggaagaacgt     9780

ggagaactgg agaggatcat tgctgacctg gaggaagaac aaagaaatct acaggtggag     9840

tatgagcagc tgaaggacca gcacctccga agggggctcc ctgtcggttc accgccagag     9900

tcgattatat ctccccatca cacgtctgag gattcagaac ttatagcaga agcaaaactc     9960

ctcaggcagc acaaaggtcg gctggaggct aggatgcaga ttttagaaga tcacaataaa    10020

cagctggagt ctcagctcca ccgcctccga cagctgctgg agcagcctga atctgattcc    10080

cgaatcaatg gtgtttcccc atgggcttct cctcagcatt ctgcactgag ctactcgctt    10140

gatccagatg cctccggccc acagttccac caggcagcgg gagaggacct gctggcccca    10200

ccgcacgaca ccagcacgga tctcacggag gtcatggagc agattcacag cacgtttcca    10260

tcttgctgcc caaatgttcc cagcaggcca caggcaatgt ga                       10302


<210>  92
<211>  360
<212>  DNA
<213>  Homo sapiens;

<400>  92
atggtgaaaa tgacaaagtc caaaactttc caagcgtatc tgccgaactg tcaccgaacg       60

tacagctgta tccactgcag agcacacctg gccaatcatg acgagctcat ctccaagtcc      120

tttcagggga gccagggacg cgcctacctc ttcaattccg tggtgaacgt gggctgcggc      180

cctgcagagg agagggtcct tctcaccggg ctgcatgcgg ttgccgacat ctactgcgag      240

aactgcaaga ccacgctcgg gtggaaatac gagcatgcct ttgagagcag tcagaaatat      300

aaggaaggaa aattcatcat tgagcttgct catatgatca aagacaatgg ctgggagtaa      360


<210>  93
<211>  1485
<212>  DNA
<213>  Homo sapiens;

<400>  93
atgtcgacca cacttctgtc cgccttctac gatgtcgact tcttgtgcaa gacagagaaa       60

tccctggcca acctcaacct gaacaacatg ctggacaaga aggcggtggg gacgcctgtg      120

gccgccgccc ccagctcggg cttcgcgccg ggattcctcc gacggcactc ggccagcaac      180

ctgcatgcac tcgcccaccc cgcgcccagc cccggcagct gctcgcccaa gttcccgggc      240

gccgctaacg gcagcagctg cggcagcgcg gcggccggcg gtccgacctc ctacggcacc      300

cttaaggagc cgtcgggggg cggcggcaca gccctgctca acaaggagaa caaattccgg      360

gaccgctcgt ttagcgagaa cggcgatcgc agccagcacc tcctgcacct gcagcagcag      420

cagaaggggg gcggcggctc ccagatcaac tccacgcgct acaagaccga gctgtgccgg      480

cccttcgagg agagcggcac gtgcaagtac ggcgaaaagt gccagttcgc gcatggcttc      540

cacgagctgc gcagcctgac tcgccatccg aagtacaaga ccgagctgtg ccgcaccttt      600

cataccatcg gcttctgccc ctatgggccg cgctgccact tcatccacaa cgcggacgag      660

cggcggcccg cgccgtcggg gggcgcctcc ggggacctgc gtgcctttgg cacgcgcgat      720

gcgttgcacc tgggcttccc gcgggagccg cggcccaagt tgcaccacag cctcagcttc      780

tcgggcttcc cgtcgggcca ccatcagccc ccgggcggcc tcgagtcgcc gctgctgctc      840

gacagcccca cgtcgcgcac gccgccgccg ccctcctgct cttcggcctc gtcctgctcc      900

tcctccgcct cctcctgttc ctcggcctcc gcggcctcca cgccctcggg cgccccgaca      960

tgctgcgcct ccgcggcggc cgcggctgcg gccgctctgc tgtacggcac cgggggcgcc     1020

gaggacctgc tggcgccggg ggccccgtgc gcggcctgct cgtcggcctc gtgcgccaac     1080

aacgccttcg ccttcggtcc ggagctcagc agcctcatca cgccgctcgc catccagacc     1140

cacaactttg ccgccgtggc cgccgccgcc tactaccgca gtcagcagca gcagcagcag     1200

cagggcctgg cgccccccgc gcagccgccg gcgccgccca gcgcgaccct ccccgccggg     1260

gccgccgcac ctccctcgcc gcccttcagc ttccagctgc cgcgccgcct gtccgactcg     1320

cccgtgttcg acgcgccccc cagccccccg gactcgctgt cggaccgcga cagctaccta     1380

agcggctccc tgagctccgg cagcctcagc ggctctgagt ctcccagcct cgaccctggc     1440

cgccgcctgc caatcttcag ccgcctctcc atctccgacg actga                     1485


<210>  94
<211>  2514
<212>  DNA
<213>  Homo sapiens;

<400>  94
atggctagca aacgaaaatc tacaactcca tgcatggttc ggacatcaca agtagtagaa       60

caagatgtgc ccgaggaagt agacagggcc aaagagaaag gaatcggcac accacagcct      120

gacgtggcca aggacagttg ggcagcagaa cttgaaaact cttccaaaga aaacgaagtg      180

atagaggtga aatctatggg ggaaagccag tccaaaaaac tccaaggtgg ttatgagtgc      240

aaatactgcc cctactccac gcaaaacctg aacgagttca cggagcatgt cgacatgcag      300

catcccaacg tgattctcaa ccccctctac gtgtgtgcag aatgtaactt cacaaccaaa      360

aagtacgact ccctatccga ccacaactcc aagttccatc ccggggaggc caacttcaag      420

ctgaagttaa ttaaacgcaa taatcaaact gtcttggaac agtccatcga aaccaccaac      480

catgtcgtgt ccatcaccac cagtggccct ggaactggtg acagtgattc tgggatctcg      540

gtgagtaaaa cccccatcat gaagcctgga aaaccaaaag cggatgccaa gaaggtgccc      600

aagaagcccg aggagatcac ccccgagaac cacgtggaag ggaccgcccg cctggtgaca      660

gacacagctg agatcctctc gagactcggc ggggtggagc tcctccaaga cacattagga      720

cacgtcatgc cttctgtaca gctgccacca aatatcaacc ttgtgcccaa ggtccctgtc      780

ccactaaata ctaccaaata caactctgcc ctggatacaa atgccacgat gatcaactct      840

ttcaacaagt ttccttaccc gacccaggct gagttgtcct ggctgacagc tgcctccaaa      900

cacccagagg agcacatcag aatctggttt gccacccagc gcttaaagca tggcatcagc      960

tggtccccag aagaggtgga ggaggcccgg aagaagatgt tcaacggcac catccagtca     1020

gtacccccga ccatcactgt gctgcccgcc cagttggccc ccacaaaggt gacgcagccc     1080

atcctccaga cggctctacc gtgccagatc ctcggccaga ctagcctggt gctgactcag     1140

gtgaccagcg ggtcaacaac cgtctcttgc tcccccatca cacttgccgt ggcaggagtc     1200

accaaccatg gccagaagag acccttggtg actccccaag ctgcccccga acccaagcgt     1260

ccacacatcg ctcaggtgcc agagccccca cccaaggtgg ccaacccccc gctcacacca     1320

gccagtgacc gcaagaagac aaaggagcag atagcacatc tcaaggccag ctttctccag     1380

agccagttcc ctgacgatgc cgaggtttac cggctcatcg aggtgactgg ccttgccagg     1440

agcgagatca agaagtggtt cagtgaccac cgatatcggt gtcaaagggg catcgtccac     1500

atcaccagcg aatcccttgc caaagaccag ttggccatcg cggcctcccg acacggtcgc     1560

acgtatcatg cgtacccaga ctttgccccc cagaagttca aagagaaaac acagggtcag     1620

gttaaaatct tggaagacag ctttttgaaa agttcttttc ctacccaagc agaactggat     1680

cggctaaggg tggagaccaa gctgagcagg agagagatcg actcctggtt ctcggagagg     1740

cggaagcttc gagacagcat ggaacaagct gtcttggatt ccatggggtc tggcaaaaaa     1800

ggccaagatg tgggagcccc caatggtgct ctgtctcgac tcgaccagct ctccggtgcc     1860

cagttaacaa gttctctgcc cagcccttcg ccagcaattg caaaaagtca agaacaggtt     1920

catctcctga ggagcacgtt tgcaagaacc cagtggccta ctccccagga gtacgaccag     1980

ttagcggcca agactggcct ggtccgaact gagattgtgc gttggttcaa ggagaacaga     2040

tgcttgctga aaacgggaac cgtgaagtgg atggagcagt accagcacca gcccatggca     2100

gatgatcacg gctacgatgc cgtagcaagg aaagcaacaa aacccatggc cgagagccca     2160

aagaacgggg gtgatgtggt tccacaatat tacaaggacc ccaaaaagct ctgcgaagag     2220

gacttggaga agttggtgac cagggtaaaa gtaggcagcg agccagcaaa agactgtttg     2280

ccagcaaagc cctcagaggc cacctcagac cggtcagagg gcagcagccg ggacggccag     2340

ggtagcgacg agaacgagga gtcgagcgtt gtggattacg tggaggtgac ggtcggggag     2400

gaggatgcga tctcagatag atcagatagc tggagtcagg ctgcggcaga aggtgtgtcg     2460

gaactggctg aatcagactc cgactgcgtc cctgcagagg ctggccaggc ctag           2514


<210>  95
<211>  918
<212>  PRT
<213>  Homo sapiens;

<400>  95

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  96
<211>  185
<212>  PRT
<213>  Homo sapiens;

<400>  96

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  97
<211>  524
<212>  PRT
<213>  Homo sapiens;

<400>  97

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  98
<211>  357
<212>  PRT
<213>  Homo sapiens;

<400>  98

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  99
<211>  786
<212>  PRT
<213>  Homo sapiens;

<400>  99

Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala 
1               5                   10                  15      


Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe 
            20                  25                  30          


Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser 
        35                  40                  45              


Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro 
    50                  55                  60                  


Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys 
65                  70                  75                  80  


Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu 
                85                  90                  95      


Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val 
            100                 105                 110         


Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala 
        115                 120                 125             


Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys 
    130                 135                 140                 


Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg 
145                 150                 155                 160 


Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val 
                165                 170                 175     


Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln 
            180                 185                 190         


Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro 
        195                 200                 205             


Pro Asp Ser Gln Ala Ser Gly Gln Gly Val Pro Leu Ile Ser Val Thr 
    210                 215                 220                 


Thr Leu Arg Arg Gly Gly Tyr Ser Thr Leu Pro Asn Pro Gln Lys Ser 
225                 230                 235                 240 


Glu Trp Ile Tyr Asp Thr Pro Val Ser Pro Gly Lys Ala Ser Val Arg 
                245                 250                 255     


Asn Thr Pro Leu Thr Ser Phe Ala Glu Glu Ser Arg Pro His Ala Leu 
            260                 265                 270         


Pro Ser Ser Ser Ser Thr Phe Tyr Asn Pro Pro Ser Gly Arg Ser Arg 
        275                 280                 285             


Ser Leu Thr Pro Gln Leu Asn Asn Asn Val Pro Met Gln Lys Lys Leu 
    290                 295                 300                 


Ser Leu Pro Glu Ile Pro Ser Tyr Gly Phe Leu Val Pro Arg Gly Thr 
305                 310                 315                 320 


Phe Pro Leu Asp Glu Asp Val Ser Tyr Lys Val Pro Ser Ser Phe Leu 
                325                 330                 335     


Ile Pro Arg Val Glu Gln Gln Asn Thr Lys Pro Asn Ile Tyr Asp Ile 
            340                 345                 350         


Pro Lys Ala Thr Ser Ser Val Ser Gln Ala Gly Lys Glu Leu Glu Lys 
        355                 360                 365             


Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp Phe 
    370                 375                 380                 


Ser Arg Arg Thr Thr Ser Pro Ser Pro Glu Pro Asp Arg Leu Ser Gly 
385                 390                 395                 400 


Ser Ser Ser Asp Ser Arg Ala Ser Ile Val Ser Ser Cys Ser Thr Thr 
                405                 410                 415     


Ser Thr Asp Asp Ser Ser Ser Ser Ser Ser Glu Glu Ser Ala Lys Glu 
            420                 425                 430         


Leu Ser Leu Asp Leu Asp Val Ala Lys Glu Thr Val Met Ala Leu Gln 
        435                 440                 445             


His Lys Val Val Ser Ser Val Ala Gly Leu Met Leu Phe Val Ser Arg 
    450                 455                 460                 


Lys Trp Arg Phe Arg Asp Tyr Leu Glu Ala Asn Ile Asp Ala Ile His 
465                 470                 475                 480 


Arg Ser Thr Asp His Ile Glu Glu Ser Val Arg Glu Phe Leu Asp Phe 
                485                 490                 495     


Ala Arg Gly Val His Gly Thr Ala Cys Asn Leu Thr Asp Ser Asn Leu 
            500                 505                 510         


Gln Asn Arg Ile Arg Asp Gln Met Gln Thr Ile Ser Asn Ser Tyr Arg 
        515                 520                 525             


Ile Leu Leu Glu Thr Lys Glu Ser Leu Asp Asn Arg Asn Trp Pro Leu 
    530                 535                 540                 


Glu Val Leu Val Thr Asp Ser Val Gln Asn Ser Pro Asp Asp Leu Glu 
545                 550                 555                 560 


Arg Phe Val Met Val Ala Arg Met Leu Pro Glu Asp Ile Lys Arg Phe 
                565                 570                 575     


Ala Ser Ile Val Ile Ala Asn Gly Arg Leu Leu Phe Lys Arg Asn Cys 
            580                 585                 590         


Glu Lys Glu Glu Thr Val Gln Leu Thr Pro Asn Ala Glu Phe Lys Cys 
        595                 600                 605             


Glu Lys Tyr Ile Gln Pro Pro Gln Arg Glu Thr Glu Ser His Gln Lys 
    610                 615                 620                 


Ser Thr Pro Ser Thr Lys Gln Arg Glu Asp Glu His Ser Ser Glu Leu 
625                 630                 635                 640 


Leu Lys Lys Asn Arg Ala Asn Ile Cys Gly Gln Asn Pro Gly Pro Leu 
                645                 650                 655     


Ile Pro Gln Pro Ser Ser Gln Gln Thr Pro Glu Arg Lys Pro Arg Leu 
            660                 665                 670         


Ser Glu His Cys Arg Leu Tyr Phe Gly Ala Leu Phe Lys Ala Ile Ser 
        675                 680                 685             


Ala Phe His Gly Ser Leu Ser Ser Ser Gln Pro Ala Glu Ile Ile Thr 
    690                 695                 700                 


Gln Ser Lys Leu Val Ile Met Val Gly Gln Lys Leu Val Asp Thr Leu 
705                 710                 715                 720 


Cys Met Glu Thr Gln Glu Arg Asp Val Arg Asn Glu Ile Leu Arg Gly 
                725                 730                 735     


Ser Ser His Leu Cys Ser Leu Leu Lys Asp Val Ala Leu Ala Thr Lys 
            740                 745                 750         


Asn Ala Val Leu Thr Tyr Pro Ser Pro Ala Ala Leu Gly His Leu Gln 
        755                 760                 765             


Ala Glu Ala Glu Lys Leu Glu Gln His Thr Arg Gln Phe Arg Gly Thr 
    770                 775                 780                 


Leu Gly 
785     


<210>  100
<211>  491
<212>  PRT
<213>  Homo sapiens;

<400>  100

Met Asp His Thr Asp Asn Glu Leu Gln Gly Thr Asn Ser Ser Gly Ser 
1               5                   10                  15      


Leu Gly Gly Leu Asp Val Arg Arg Arg Ile Pro Ile Lys Leu Ile Ser 
            20                  25                  30          


Lys Gln Ala Asn Lys Ala Lys Pro Ala Pro Arg Thr Gln Arg Thr Ile 
        35                  40                  45              


Asn Arg Met Pro Ala Lys Ala Pro Pro Gly Asp Glu Glu Gly Phe Asp 
    50                  55                  60                  


Tyr Asn Glu Glu Glu Arg Tyr Asp Cys Lys Gly Gly Glu Leu Phe Ala 
65                  70                  75                  80  


Asn Gln Arg Arg Phe Pro Gly His Leu Phe Trp Asp Phe Gln Ile Asn 
                85                  90                  95      


Ile Leu Gly Glu Lys Asp Asp Thr Pro Val His Phe Cys Asp Lys Cys 
            100                 105                 110         


Gly Leu Pro Ile Lys Ile Tyr Gly Arg Met Ile Pro Cys Lys His Val 
        115                 120                 125             


Phe Cys Tyr Asp Cys Ala Ile Leu His Glu Lys Lys Gly Asp Lys Met 
    130                 135                 140                 


Cys Pro Gly Cys Ser Asp Pro Val Gln Arg Ile Glu Gln Cys Thr Arg 
145                 150                 155                 160 


Gly Ser Leu Phe Met Cys Ser Ile Val Gln Gly Cys Lys Arg Thr Tyr 
                165                 170                 175     


Leu Ser Gln Arg Asp Leu Gln Ala His Ile Asn His Arg His Met Arg 
            180                 185                 190         


Ala Gly Lys Pro Val Thr Arg Ala Ser Leu Glu Asn Val His Pro Pro 
        195                 200                 205             


Ile Ala Pro Pro Pro Thr Glu Ile Pro Glu Arg Phe Ile Met Pro Pro 
    210                 215                 220                 


Asp Lys His His Met Ser His Ile Pro Pro Lys Gln His Ile Met Met 
225                 230                 235                 240 


Pro Pro Pro Pro Leu Gln His Val Pro His Glu His Tyr Asn Gln Pro 
                245                 250                 255     


His Glu Asp Ile Arg Ala Pro Pro Ala Glu Leu Ser Met Ala Pro Pro 
            260                 265                 270         


Pro Pro Arg Ser Val Ser Gln Glu Thr Phe Arg Ile Ser Thr Arg Lys 
        275                 280                 285             


His Ser Asn Leu Ile Thr Val Pro Ile Gln Asp Asp Ser Asn Ser Gly 
    290                 295                 300                 


Ala Arg Glu Pro Pro Pro Pro Ala Pro Ala Pro Ala His His His Pro 
305                 310                 315                 320 


Glu Tyr Gln Gly Gln Pro Val Val Ser His Pro His His Ile Met Pro 
                325                 330                 335     


Pro Gln Gln His Tyr Ala Pro Pro Pro Pro Pro Pro Pro Pro Ile Ser 
            340                 345                 350         


His Pro Met Pro His Pro Pro Gln Ala Ala Gly Thr Pro His Leu Val 
        355                 360                 365             


Tyr Ser Gln Ala Pro Pro Pro Pro Met Thr Ser Ala Pro Pro Pro Ile 
    370                 375                 380                 


Thr Pro Pro Pro Gly His Ile Ile Ala Gln Met Pro Pro Tyr Met Asn 
385                 390                 395                 400 


His Pro Pro Pro Gly Pro Pro Pro Pro Gln His Gly Gly Pro Pro Val 
                405                 410                 415     


Thr Ala Pro Pro Pro His His Tyr Asn Pro Asn Ser Leu Pro Gln Phe 
            420                 425                 430         


Thr Glu Asp Gln Gly Thr Leu Ser Pro Pro Phe Thr Gln Pro Gly Gly 
        435                 440                 445             


Met Ser Pro Gly Ile Trp Pro Ala Pro Arg Gly Pro Pro Pro Pro Pro 
    450                 455                 460                 


Arg Leu Gln Gly Pro Pro Ser Gln Thr Pro Leu Pro Gly Pro His His 
465                 470                 475                 480 


Pro Asp Gln Thr Arg Tyr Arg Pro Tyr Tyr Gln 
                485                 490     


<210>  101
<211>  580
<212>  PRT
<213>  Homo sapiens;

<400>  101

Met Lys Glu Asn Lys Glu Asn Ser Ser Pro Ser Val Thr Ser Ala Asn 
1               5                   10                  15      


Leu Asp His Thr Lys Pro Cys Trp Tyr Trp Asp Lys Lys Asp Leu Ala 
            20                  25                  30          


His Thr Pro Ser Gln Leu Glu Gly Leu Asp Pro Ala Thr Glu Ala Arg 
        35                  40                  45              


Tyr Arg Arg Glu Gly Ala Arg Phe Ile Phe Asp Val Gly Thr Arg Leu 
    50                  55                  60                  


Gly Leu His Tyr Asp Thr Leu Ala Thr Gly Ile Ile Tyr Phe His Arg 
65                  70                  75                  80  


Phe Tyr Met Phe His Ser Phe Lys Gln Phe Pro Arg Tyr Val Thr Gly 
                85                  90                  95      


Ala Cys Cys Leu Phe Leu Ala Gly Lys Val Glu Glu Thr Pro Lys Lys 
            100                 105                 110         


Cys Lys Asp Ile Ile Lys Thr Ala Arg Ser Leu Leu Asn Asp Val Gln 
        115                 120                 125             


Phe Gly Gln Phe Gly Asp Asp Pro Lys Glu Glu Val Met Val Leu Glu 
    130                 135                 140                 


Arg Ile Leu Leu Gln Thr Ile Lys Phe Asp Leu Gln Val Glu His Pro 
145                 150                 155                 160 


Tyr Gln Phe Leu Leu Lys Tyr Ala Lys Gln Leu Lys Gly Asp Lys Asn 
                165                 170                 175     


Lys Ile Gln Lys Leu Val Gln Met Ala Trp Thr Phe Val Asn Asp Ser 
            180                 185                 190         


Leu Cys Thr Thr Leu Ser Leu Gln Trp Glu Pro Glu Ile Ile Ala Val 
        195                 200                 205             


Ala Val Met Tyr Leu Ala Gly Arg Leu Cys Lys Phe Glu Ile Gln Glu 
    210                 215                 220                 


Trp Thr Ser Lys Pro Met Tyr Arg Arg Trp Trp Glu Gln Phe Val Gln 
225                 230                 235                 240 


Asp Val Pro Val Asp Val Leu Glu Asp Ile Cys His Gln Ile Leu Asp 
                245                 250                 255     


Leu Tyr Ser Gln Gly Lys Gln Gln Met Pro His His Thr Pro His Gln 
            260                 265                 270         


Leu Gln Gln Pro Pro Ser Leu Gln Pro Thr Pro Gln Val Pro Gln Val 
        275                 280                 285             


Gln Gln Ser Gln Pro Ser Gln Ser Ser Glu Pro Ser Gln Pro Gln Gln 
    290                 295                 300                 


Lys Asp Pro Gln Gln Pro Ala Gln Gln Gln Gln Pro Ala Gln Gln Pro 
305                 310                 315                 320 


Lys Lys Pro Ser Pro Gln Pro Ser Ser Pro Arg Gln Val Lys Arg Ala 
                325                 330                 335     


Val Val Val Ser Pro Lys Glu Glu Asn Lys Ala Ala Glu Pro Pro Pro 
            340                 345                 350         


Pro Lys Ile Pro Lys Ile Glu Thr Thr His Pro Pro Leu Pro Pro Ala 
        355                 360                 365             


His Pro Pro Pro Asp Arg Lys Pro Pro Leu Ala Ala Ala Leu Gly Glu 
    370                 375                 380                 


Ala Glu Pro Pro Gly Pro Val Asp Ala Thr Asp Leu Pro Lys Val Gln 
385                 390                 395                 400 


Ile Pro Pro Pro Ala His Pro Ala Pro Val His Gln Pro Pro Pro Leu 
                405                 410                 415     


Pro His Arg Pro Pro Pro Pro Pro Pro Ser Ser Tyr Met Thr Gly Met 
            420                 425                 430         


Ser Thr Thr Ser Ser Tyr Met Ser Gly Glu Gly Tyr Gln Ser Leu Gln 
        435                 440                 445             


Ser Met Met Lys Thr Glu Gly Pro Ser Tyr Gly Ala Leu Pro Pro Ala 
    450                 455                 460                 


Tyr Gly Pro Pro Ala His Leu Pro Tyr His Pro His Val Tyr Pro Pro 
465                 470                 475                 480 


Asn Pro Pro Pro Pro Pro Val Pro Pro Pro Pro Ala Ser Phe Pro Pro 
                485                 490                 495     


Pro Ala Ile Pro Pro Pro Thr Pro Gly Tyr Pro Pro Pro Pro Pro Thr 
            500                 505                 510         


Tyr Asn Pro Asn Phe Pro Pro Pro Pro Pro Arg Leu Pro Pro Thr His 
        515                 520                 525             


Ala Val Pro Pro His Pro Pro Pro Gly Leu Gly Leu Pro Pro Ala Ser 
    530                 535                 540                 


Tyr Pro Pro Pro Ala Val Pro Pro Gly Gly Gln Pro Pro Val Pro Pro 
545                 550                 555                 560 


Pro Ile Pro Pro Pro Gly Met Pro Pro Val Gly Gly Leu Gly Arg Ala 
                565                 570                 575     


Ala Trp Met Arg 
            580 


<210>  102
<211>  267
<212>  PRT
<213>  Homo sapiens;

<400>  102

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210>  103
<211>  201
<212>  PRT
<213>  Homo sapiens;

<400>  103

Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln 
        115                 120                 125             


Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val 
    130                 135                 140                 


Pro Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln 
145                 150                 155                 160 


Ile Arg Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp 
                165                 170                 175     


Ile His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr 
            180                 185                 190         


Ser Ile Cys Glu Lys Lys Phe Ser Met 
        195                 200     


<210>  104
<211>  707
<212>  PRT
<213>  Homo sapiens;

<400>  104

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  105
<211>  388
<212>  PRT
<213>  Homo sapiens;

<400>  105

Met Gln Arg Leu Leu Phe Pro Pro Leu Arg Ala Leu Lys Gly Arg Gln 
1               5                   10                  15      


Tyr Leu Pro Leu Leu Ala Pro Arg Ala Ala Pro Arg Ala Gln Cys Asp 
            20                  25                  30          


Cys Ile Arg Arg Pro Leu Arg Pro Gly Gln Tyr Ser Thr Ile Ser Glu 
        35                  40                  45              


Val Ala Leu Gln Ser Gly Arg Gly Thr Val Ser Leu Pro Ser Lys Ala 
    50                  55                  60                  


Ala Glu Arg Val Val Gly Arg Trp Leu Leu Val Cys Ser Gly Thr Val 
65                  70                  75                  80  


Ala Gly Ala Val Ile Leu Gly Gly Val Thr Arg Leu Thr Glu Ser Gly 
                85                  90                  95      


Leu Ser Met Val Asp Trp His Leu Ile Lys Glu Met Lys Pro Pro Thr 
            100                 105                 110         


Ser Gln Glu Glu Trp Glu Ala Glu Phe Gln Arg Tyr Gln Gln Phe Pro 
        115                 120                 125             


Glu Phe Lys Ile Leu Asn His Asp Met Thr Leu Thr Glu Phe Lys Phe 
    130                 135                 140                 


Ile Trp Tyr Met Glu Tyr Ser His Arg Met Trp Gly Arg Leu Val Gly 
145                 150                 155                 160 


Leu Val Tyr Ile Leu Pro Ala Ala Tyr Phe Trp Arg Lys Gly Trp Leu 
                165                 170                 175     


Ser Arg Gly Met Lys Gly Arg Val Leu Ala Leu Cys Gly Leu Val Cys 
            180                 185                 190         


Phe Gln Gly Leu Leu Gly Trp Tyr Met Val Lys Ser Gly Leu Glu Glu 
        195                 200                 205             


Lys Ser Asp Ser His Asp Ile Pro Arg Val Ser Gln Tyr Arg Leu Ala 
    210                 215                 220                 


Ala His Leu Gly Ser Ala Leu Val Leu Tyr Cys Ala Ser Leu Trp Thr 
225                 230                 235                 240 


Ser Leu Ser Leu Leu Leu Pro Pro His Lys Leu Pro Glu Thr His Gln 
                245                 250                 255     


Leu Leu Gln Leu Arg Arg Phe Ala His Gly Thr Ala Gly Leu Val Phe 
            260                 265                 270         


Leu Thr Ala Leu Ser Gly Ala Phe Val Ala Gly Leu Asp Ala Gly Leu 
        275                 280                 285             


Val Tyr Asn Ser Phe Pro Lys Met Gly Glu Ser Trp Ile Pro Glu Asp 
    290                 295                 300                 


Leu Phe Thr Phe Ser Pro Ile Leu Arg Asn Val Phe Glu Asn Pro Thr 
305                 310                 315                 320 


Met Val Gln Phe Asp His Arg Ile Leu Gly Ile Thr Ser Val Thr Ala 
                325                 330                 335     


Ile Thr Val Leu Tyr Phe Leu Ser Arg Arg Ile Pro Leu Pro Arg Arg 
            340                 345                 350         


Thr Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Gly 
        355                 360                 365             


Pro Val Leu Phe Asn Phe Thr Phe Lys Ile Ser Asp Leu Asp Glu Gly 
    370                 375                 380                 


Ile Arg Asn Ile 
385             


<210>  106
<211>  2039
<212>  PRT
<213>  Homo sapiens;

<400>  106

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Thr  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  107
<211>  1198
<212>  PRT
<213>  Homo sapiens;

<400>  107

Met Arg Ser Leu Arg Lys Lys Arg Glu Lys Pro Arg Pro Glu Gln Trp 
1               5                   10                  15      


Lys Gly Leu Pro Gly Pro Pro Arg Ala Pro Glu Pro Glu Asp Val Ala 
            20                  25                  30          


Val Pro Gly Gly Val Asp Leu Leu Thr Leu Pro Gln Leu Cys Phe Pro 
        35                  40                  45              


Gly Gly Val Cys Val Ala Thr Glu Pro Lys Glu Asp Cys Val His Phe 
    50                  55                  60                  


Leu Val Leu Thr Asp Val Cys Gly Asn Arg Thr Tyr Gly Val Val Ala 
65                  70                  75                  80  


Gln Tyr Tyr Arg Pro Leu His Asp Glu Tyr Cys Phe Tyr Asn Gly Lys 
                85                  90                  95      


Thr His Arg Glu Cys Pro Gly Cys Phe Val Pro Phe Ala Val Cys Val 
            100                 105                 110         


Val Ser Arg Phe Pro Tyr Tyr Asn Ser Leu Lys Asp Cys Leu Ser Cys 
        115                 120                 125             


Leu Leu Ala Leu Leu Lys Pro Cys Lys Asp Phe Glu Val Asp Ser His 
    130                 135                 140                 


Ile Lys Asp Phe Ala Ala Lys Leu Ser Leu Ile Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Gly Pro Leu His Leu Val Phe Asn Met Lys Ser Leu Gln Ile Val Leu 
                165                 170                 175     


Pro Ala Arg Ala Asp Pro Glu Ser Pro Ile Leu Asp Leu Asp Leu His 
            180                 185                 190         


Leu Pro Leu Leu Cys Phe Arg Pro Glu Lys Val Leu Gln Ile Leu Thr 
        195                 200                 205             


Cys Ile Leu Thr Glu Gln Arg Ile Val Phe Phe Ser Ser Asp Trp Ala 
    210                 215                 220                 


Leu Leu Thr Leu Val Thr Glu Cys Phe Met Ala Tyr Leu Tyr Pro Leu 
225                 230                 235                 240 


Gln Trp Gln His Pro Phe Val Pro Ile Leu Ser Asp Gln Met Leu Asp 
                245                 250                 255     


Phe Val Met Ala Pro Thr Ser Phe Leu Met Gly Cys His Leu Asp His 
            260                 265                 270         


Phe Glu Glu Val Ser Lys Glu Ala Asp Gly Leu Val Leu Ile Asn Ile 
        275                 280                 285             


Asp His Gly Ser Ile Thr Tyr Ser Lys Ser Thr Asp Asp Asn Val Asp 
    290                 295                 300                 


Ile Pro Asp Val Pro Leu Leu Ala Ala Gln Thr Phe Ile Gln Arg Val 
305                 310                 315                 320 


Gln Ser Leu Gln Leu His His Glu Leu His Ala Ala His Leu Leu Ser 
                325                 330                 335     


Ser Thr Asp Leu Lys Glu Gly Arg Ala His Arg Arg Ser Trp Gln Gln 
            340                 345                 350         


Lys Leu Asn Cys Gln Ile Gln Gln Thr Thr Leu Gln Leu Leu Val Ser 
        355                 360                 365             


Ile Phe Arg Asp Val Lys Asn His Leu Asn Tyr Glu His Arg Val Phe 
    370                 375                 380                 


Asn Ser Glu Glu Phe Leu Lys Thr Arg Ala Pro Gly Asp His Gln Phe 
385                 390                 395                 400 


Tyr Lys Gln Val Leu Asp Thr Tyr Met Phe His Ser Phe Leu Lys Ala 
                405                 410                 415     


Arg Leu Asn Arg Arg Met Asp Ala Phe Ala Gln Met Asp Leu Asp Thr 
            420                 425                 430         


Gln Ser Glu Glu Asp Arg Ile Asn Gly Met Leu Leu Ser Pro Arg Arg 
        435                 440                 445             


Pro Thr Val Glu Lys Arg Ala Ser Arg Lys Ser Ser His Leu His Val 
    450                 455                 460                 


Thr His Arg Arg Met Val Val Ser Met Pro Asn Leu Gln Asp Ile Ala 
465                 470                 475                 480 


Met Pro Glu Leu Ala Pro Arg Asn Ser Ser Leu Arg Leu Thr Asp Thr 
                485                 490                 495     


Ala Gly Cys Arg Gly Ser Ser Ala Val Leu Asn Val Thr Pro Lys Ser 
            500                 505                 510         


Pro Tyr Thr Phe Lys Ile Pro Glu Ile His Phe Pro Leu Glu Ser Lys 
        515                 520                 525             


Cys Val Gln Ala Tyr His Ala His Phe Val Ser Met Leu Ser Glu Ala 
    530                 535                 540                 


Met Cys Phe Leu Ala Pro Asp Asn Ser Leu Leu Leu Ala Arg Tyr Leu 
545                 550                 555                 560 


Tyr Leu Arg Gly Leu Val Tyr Leu Met Gln Gly Gln Leu Leu Asn Ala 
                565                 570                 575     


Leu Leu Asp Phe Gln Asn Leu Tyr Lys Thr Asp Ile Arg Ile Phe Pro 
            580                 585                 590         


Thr Asp Leu Val Lys Arg Thr Val Glu Ser Met Ser Ala Pro Glu Trp 
        595                 600                 605             


Glu Gly Ala Glu Gln Ala Pro Glu Leu Met Arg Leu Ile Ser Glu Ile 
    610                 615                 620                 


Leu Asp Lys Pro His Glu Ala Ser Lys Leu Asp Asp His Val Lys Lys 
625                 630                 635                 640 


Phe Lys Leu Pro Lys Lys His Met Gln Leu Gly Asp Phe Met Lys Arg 
                645                 650                 655     


Val Gln Glu Ser Gly Ile Val Lys Asp Ala Ser Ile Ile His Arg Leu 
            660                 665                 670         


Phe Glu Ala Leu Thr Val Gly Gln Glu Lys Gln Ile Asp Pro Glu Thr 
        675                 680                 685             


Phe Lys Asp Phe Tyr Asn Cys Trp Lys Glu Thr Glu Ala Glu Ala Gln 
    690                 695                 700                 


Glu Val Ser Leu Pro Trp Leu Val Met Glu His Leu Asp Lys Asn Glu 
705                 710                 715                 720 


Cys Val Cys Lys Leu Ser Ser Ser Val Lys Thr Asn Leu Gly Val Gly 
                725                 730                 735     


Lys Ile Ala Met Thr Gln Lys Arg Leu Phe Leu Leu Thr Glu Gly Arg 
            740                 745                 750         


Pro Gly Tyr Leu Glu Ile Ser Thr Phe Arg Asn Ile Glu Glu Val Arg 
        755                 760                 765             


Arg Thr Thr Thr Thr Phe Leu Leu Arg Arg Ile Pro Thr Leu Lys Ile 
    770                 775                 780                 


Arg Val Ala Ser Lys Lys Glu Val Phe Glu Ala Asn Leu Lys Thr Glu 
785                 790                 795                 800 


Cys Asp Leu Trp His Leu Met Val Lys Glu Met Trp Ala Gly Lys Lys 
                805                 810                 815     


Leu Ala Asp Asp His Lys Asp Pro His Tyr Val Gln Gln Ala Leu Thr 
            820                 825                 830         


Asn Val Leu Leu Met Asp Ala Val Val Gly Thr Leu Gln Ser Pro Gly 
        835                 840                 845             


Ala Ile Tyr Ala Ala Ser Lys Leu Ser Tyr Phe Asp Lys Met Ser Asn 
    850                 855                 860                 


Glu Met Pro Met Thr Leu Pro Glu Thr Thr Leu Glu Thr Leu Lys His 
865                 870                 875                 880 


Lys Ile Asn Pro Ser Ala Gly Glu Ala Phe Pro Gln Ala Val Asp Val 
                885                 890                 895     


Leu Leu Tyr Thr Pro Gly His Leu Asp Pro Ala Glu Lys Val Glu Asp 
            900                 905                 910         


Ala His Pro Lys Leu Trp Cys Ala Leu Ser Glu Gly Lys Val Thr Val 
        915                 920                 925             


Phe Asn Ala Ser Ser Trp Thr Ile His Gln His Ser Phe Lys Val Gly 
    930                 935                 940                 


Thr Ala Lys Val Asn Cys Met Val Met Ala Asp Gln Asn Gln Val Trp 
945                 950                 955                 960 


Val Gly Ser Glu Asp Ser Val Ile Tyr Ile Ile Asn Val His Ser Met 
                965                 970                 975     


Ser Cys Asn Lys Gln Leu Thr Ala His Cys Ser Ser Val Thr Asp Leu 
            980                 985                 990         


Ile Val Gln Asp Gly Gln Glu Ala  Pro Ser Asn Val Tyr  Ser Cys Ser 
        995                 1000                 1005             


Met Asp  Gly Met Val Leu Val  Trp Asn Val Ser Thr  Leu Gln Val 
    1010                 1015                 1020             


Thr Ser  Arg Phe Gln Leu Pro  Arg Gly Gly Leu Thr  Ser Ile Arg 
    1025                 1030                 1035             


Leu His  Gly Gly Arg Leu Trp  Cys Cys Thr Gly Asn  Ser Ile Met 
    1040                 1045                 1050             


Val Met  Lys Met Asn Gly Ser  Leu His Gln Glu Leu  Lys Ile Glu 
    1055                 1060                 1065             


Glu Asn  Phe Lys Asp Thr Ser  Thr Ser Phe Leu Ala  Phe Gln Leu 
    1070                 1075                 1080             


Leu Pro  Glu Glu Glu Gln Leu  Trp Ala Ala Cys Ala  Gly Arg Ser 
    1085                 1090                 1095             


Glu Val  Tyr Ile Trp Ser Leu  Lys Asp Leu Ala Gln  Pro Pro Gln 
    1100                 1105                 1110             


Arg Val  Pro Leu Glu Asp Cys  Ser Glu Ile Asn Cys  Met Ile Arg 
    1115                 1120                 1125             


Val Lys  Lys Gln Val Trp Val  Gly Ser Arg Gly Leu  Gly Gln Gly 
    1130                 1135                 1140             


Thr Pro  Lys Gly Lys Ile Tyr  Val Ile Asp Ala Glu  Arg Lys Thr 
    1145                 1150                 1155             


Val Glu  Lys Glu Leu Val Ala  His Met Asp Thr Val  Arg Thr Leu 
    1160                 1165                 1170             


Cys Ser  Ala Glu Asp Arg Tyr  Val Leu Ser Gly Ser  Gly Arg Glu 
    1175                 1180                 1185             


Glu Gly  Lys Val Ala Ile Trp  Lys Gly Glu 
    1190                 1195             


<210>  108
<211>  1870
<212>  PRT
<213>  Homo sapiens;

<400>  108

Met Ala Arg Trp Ile Pro Thr Lys Arg Gln Lys Tyr Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Tyr Asn Ala Ser Gln Asp Val Glu Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Thr Val His Ile Leu Glu Met Tyr Glu Gly Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Thr Leu Gln Asn Lys Ser Lys Lys Gly Ile Phe Pro Glu Thr Tyr Ile 
    50                  55                  60                  


His Leu Lys Glu Ala Thr Val Glu Asp Leu Gly Gln His Glu Thr Val 
65                  70                  75                  80  


Ile Pro Gly Glu Leu Pro Leu Val Gln Glu Leu Thr Ser Thr Leu Arg 
                85                  90                  95      


Glu Trp Ala Val Ile Trp Arg Lys Leu Tyr Val Asn Asn Lys Leu Thr 
            100                 105                 110         


Leu Phe Arg Gln Leu Gln Gln Met Thr Tyr Ser Leu Ile Glu Trp Arg 
        115                 120                 125             


Ser Gln Ile Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Ala Glu Leu 
    130                 135                 140                 


Lys Lys Lys Val Thr Ala Lys Ile Asp His Gly Asn Arg Met Leu Gly 
145                 150                 155                 160 


Leu Asp Leu Val Val Arg Asp Asp Asn Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Glu Thr Ser Thr Ile Ala Leu Phe Lys Ala His Glu Val Ala Ser Lys 
            180                 185                 190         


Arg Ile Glu Glu Lys Ile Gln Glu Glu Lys Ser Ile Leu Gln Asn Leu 
        195                 200                 205             


Asp Leu Arg Gly Gln Ser Ile Phe Ser Thr Ile His Thr Tyr Gly Leu 
    210                 215                 220                 


Tyr Val Asn Phe Lys Asn Phe Val Cys Asn Ile Gly Glu Asp Ala Glu 
225                 230                 235                 240 


Leu Phe Met Ala Leu Tyr Asp Pro Asp Gln Ser Thr Phe Ile Ser Glu 
                245                 250                 255     


Asn Tyr Leu Ile Arg Trp Gly Ser Asn Gly Met Pro Lys Glu Ile Glu 
            260                 265                 270         


Lys Leu Asn Asn Leu Gln Ala Val Phe Thr Asp Leu Ser Ser Met Asp 
        275                 280                 285             


Leu Ile Arg Pro Arg Val Ser Leu Val Cys Gln Ile Val Arg Val Gly 
    290                 295                 300                 


His Met Glu Leu Lys Glu Gly Lys Lys His Thr Cys Gly Leu Arg Arg 
305                 310                 315                 320 


Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile His Gly Lys 
                325                 330                 335     


Val Asp Asp Glu Glu Lys Gln His Phe Ile Pro Phe Gln Gln Ile Ala 
            340                 345                 350         


Met Glu Thr Tyr Ile Arg Gln Arg Gln Leu Ile Met Ser Pro Leu Ile 
        355                 360                 365             


Thr Ser His Val Ile Gly Glu Asn Glu Pro Leu Thr Ser Val Leu Asn 
    370                 375                 380                 


Lys Val Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp 
385                 390                 395                 400 


Val Ser Leu Lys Leu Leu Pro Gly Asp Leu Thr Gln Val Gln Lys Asn 
                405                 410                 415     


Phe Ser His Leu Val Asp Arg Ser Thr Ala Ile Ala Arg Lys Met Gly 
            420                 425                 430         


Phe Pro Glu Ile Ile Leu Pro Gly Asp Val Arg Asn Asp Ile Tyr Val 
        435                 440                 445             


Thr Leu Ile His Gly Glu Phe Asp Lys Gly Lys Lys Lys Thr Pro Lys 
    450                 455                 460                 


Asn Val Glu Val Thr Met Ser Val His Asp Glu Glu Gly Lys Leu Leu 
465                 470                 475                 480 


Glu Lys Ala Ile His Pro Gly Ala Gly Tyr Glu Gly Ile Ser Glu Tyr 
                485                 490                 495     


Lys Ser Val Val Tyr Tyr Gln Val Lys Gln Pro Cys Trp Tyr Glu Thr 
            500                 505                 510         


Val Lys Val Ser Ile Ala Ile Glu Glu Val Thr Arg Cys His Ile Arg 
        515                 520                 525             


Phe Thr Phe Arg His Arg Ser Ser Gln Glu Thr Arg Asp Lys Ser Glu 
    530                 535                 540                 


Arg Ala Phe Gly Val Ala Phe Val Lys Leu Met Asn Pro Asp Gly Thr 
545                 550                 555                 560 


Thr Leu Gln Asp Gly Arg His Asp Leu Val Val Tyr Lys Gly Asp Asn 
                565                 570                 575     


Lys Lys Met Glu Asp Ala Lys Phe Tyr Leu Thr Leu Pro Gly Thr Lys 
            580                 585                 590         


Met Glu Met Glu Glu Lys Glu Leu Gln Ala Ser Lys Asn Leu Val Thr 
        595                 600                 605             


Phe Thr Pro Ser Lys Asp Ser Thr Lys Asp Ser Phe Gln Ile Ala Thr 
    610                 615                 620                 


Leu Ile Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu 
625                 630                 635                 640 


Leu Asn Trp Arg Ser Asn Ser Gln Asn Ile Lys His Asn Leu Lys Lys 
                645                 650                 655     


Leu Met Glu Val Asp Gly Gly Glu Ile Val Lys Phe Leu Gln Asp Thr 
            660                 665                 670         


Leu Asp Ala Leu Phe Asn Ile Met Met Glu Met Ser Asp Ser Glu Thr 
        675                 680                 685             


Tyr Asp Phe Leu Val Phe Asp Ala Leu Val Phe Ile Ile Ser Leu Ile 
    690                 695                 700                 


Gly Asp Ile Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile 
705                 710                 715                 720 


Tyr Lys His Phe Ser Ala Thr Leu Ala Tyr Val Lys Leu Ser Lys Val 
                725                 730                 735     


Leu Asn Phe Tyr Val Ala Asn Ala Asp Asp Ser Ser Lys Thr Glu Leu 
            740                 745                 750         


Leu Phe Ala Ala Leu Lys Ala Leu Lys Tyr Leu Phe Arg Phe Ile Ile 
        755                 760                 765             


Gln Ser Arg Val Leu Tyr Leu Arg Phe Tyr Gly Gln Ser Lys Asp Gly 
    770                 775                 780                 


Asp Glu Phe Asn Asn Ser Ile Arg Gln Leu Phe Leu Ala Phe Asn Met 
785                 790                 795                 800 


Leu Met Asp Arg Pro Leu Glu Glu Ala Val Lys Ile Lys Gly Ala Ala 
                805                 810                 815     


Leu Lys Tyr Leu Pro Ser Ile Ile Asn Asp Val Lys Leu Val Phe Asp 
            820                 825                 830         


Pro Val Glu Leu Ser Val Leu Phe Cys Lys Phe Ile Gln Ser Ile Pro 
        835                 840                 845             


Asp Asn Gln Leu Val Arg Gln Lys Leu Asn Cys Met Thr Lys Ile Val 
    850                 855                 860                 


Glu Ser Thr Leu Phe Arg Gln Ser Glu Cys Arg Glu Val Leu Leu Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Gln Leu Ser Gly Gln Leu Asp Asp Asn Ser Asn Lys 
                885                 890                 895     


Pro Asp His Glu Ala Ser Ser Gln Leu Leu Ser Asn Ile Leu Glu Val 
            900                 905                 910         


Leu Asp Arg Lys Asp Val Gly Ala Thr Ala Val His Ile Gln Leu Ile 
        915                 920                 925             


Met Glu Arg Leu Leu Arg Arg Ile Asn Arg Thr Val Ile Gly Met Asn 
    930                 935                 940                 


Arg Gln Ser Pro His Ile Gly Ser Phe Val Ala Cys Met Ile Ala Leu 
945                 950                 955                 960 


Leu Gln Gln Met Asp Asp Ser His Tyr Ser His Tyr Ile Ser Thr Phe 
                965                 970                 975     


Lys Thr Arg Gln Asp Ile Ile Asp Phe Leu Met Glu Thr Phe Ile Met 
            980                 985                 990         


Phe Lys Asp Leu Ile Gly Lys Asn  Val Tyr Ala Lys Asp  Trp Met Val 
        995                 1000                 1005             


Met Asn  Met Thr Gln Asn Arg  Val Phe Leu Arg Ala  Ile Asn Gln 
    1010                 1015                 1020             


Phe Ala  Glu Val Leu Thr Arg  Phe Phe Met Asp Gln  Ala Ser Phe 
    1025                 1030                 1035             


Glu Leu  Gln Leu Trp Asn Asn  Tyr Phe His Leu Ala  Val Ala Phe 
    1040                 1045                 1050             


Leu Thr  His Glu Ser Leu Gln  Leu Glu Thr Phe Ser  Gln Ala Lys 
    1055                 1060                 1065             


Arg Asn  Lys Ile Val Lys Lys  Tyr Gly Asp Met Arg  Lys Glu Ile 
    1070                 1075                 1080             


Gly Phe  Arg Ile Arg Asp Met  Trp Tyr Asn Leu Gly  Pro His Lys 
    1085                 1090                 1095             


Ile Lys  Phe Ile Pro Ser Met  Val Gly Pro Ile Leu  Glu Val Thr 
    1100                 1105                 1110             


Leu Thr  Pro Glu Val Glu Leu  Arg Lys Ala Thr Ile  Pro Ile Phe 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Cys Glu  Phe Asn Phe Ser Gly  Asn Gly Asn 
    1130                 1135                 1140             


Phe His  Met Phe Glu Asn Glu  Leu Ile Thr Lys Leu  Asp Gln Glu 
    1145                 1150                 1155             


Val Glu  Gly Gly Arg Gly Asp  Glu Gln Tyr Lys Val  Leu Leu Glu 
    1160                 1165                 1170             


Lys Leu  Leu Leu Glu His Cys  Arg Lys His Lys Tyr  Leu Ser Ser 
    1175                 1180                 1185             


Ser Gly  Glu Val Phe Ala Leu  Leu Val Ser Ser Leu  Leu Glu Asn 
    1190                 1195                 1200             


Leu Leu  Asp Tyr Arg Thr Ile  Ile Met Gln Asp Glu  Ser Lys Glu 
    1205                 1210                 1215             


Asn Arg  Met Ser Cys Thr Val  Asn Val Leu Asn Phe  Tyr Lys Glu 
    1220                 1225                 1230             


Lys Lys  Arg Glu Asp Ile Tyr  Ile Arg Tyr Leu Tyr  Lys Leu Arg 
    1235                 1240                 1245             


Asp Leu  His Arg Asp Cys Glu  Asn Tyr Thr Glu Ala  Ala Tyr Thr 
    1250                 1255                 1260             


Leu Leu  Leu His Ala Glu Leu  Leu Gln Trp Ser Asp  Lys Pro Cys 
    1265                 1270                 1275             


Val Pro  His Leu Leu Gln Lys  Asp Ser Tyr Tyr Val  Tyr Thr Gln 
    1280                 1285                 1290             


Gln Glu  Leu Lys Glu Lys Leu  Tyr Gln Glu Ile Ile  Ser Tyr Phe 
    1295                 1300                 1305             


Asp Lys  Gly Lys Met Trp Glu  Lys Ala Ile Lys Leu  Ser Lys Glu 
    1310                 1315                 1320             


Leu Ala  Glu Thr Tyr Glu Ser  Lys Val Phe Asp Tyr  Glu Gly Leu 
    1325                 1330                 1335             


Gly Asn  Leu Leu Lys Lys Arg  Ala Ser Phe Tyr Glu  Asn Ile Ile 
    1340                 1345                 1350             


Lys Ala  Met Arg Pro Gln Pro  Glu Tyr Phe Ala Val  Gly Tyr Tyr 
    1355                 1360                 1365             


Gly Gln  Gly Phe Pro Ser Phe  Leu Arg Asn Lys Ile  Phe Ile Tyr 
    1370                 1375                 1380             


Arg Gly  Lys Glu Tyr Glu Arg  Arg Glu Asp Phe Ser  Leu Arg Leu 
    1385                 1390                 1395             


Leu Thr  Gln Phe Pro Asn Ala  Glu Lys Met Thr Ser  Thr Thr Pro 
    1400                 1405                 1410             


Pro Gly  Glu Asp Ile Lys Ser  Ser Pro Lys Gln Tyr  Met Gln Cys 
    1415                 1420                 1425             


Phe Thr  Val Lys Pro Val Met  Ser Leu Pro Pro Ser  Tyr Lys Asp 
    1430                 1435                 1440             


Lys Pro  Val Pro Glu Gln Ile  Leu Asn Tyr Tyr Arg  Ala Asn Glu 
    1445                 1450                 1455             


Val Gln  Gln Phe Arg Tyr Ser  Arg Pro Phe Arg Lys  Gly Glu Lys 
    1460                 1465                 1470             


Asp Pro  Asp Asn Glu Phe Ala  Thr Met Trp Ile Glu  Arg Thr Thr 
    1475                 1480                 1485             


Tyr Thr  Thr Ala Tyr Thr Phe  Pro Gly Ile Leu Lys  Trp Phe Glu 
    1490                 1495                 1500             


Val Lys  Gln Ile Ser Thr Glu  Glu Ile Ser Pro Leu  Glu Asn Ala 
    1505                 1510                 1515             


Ile Glu  Thr Met Glu Leu Thr  Asn Glu Arg Ile Ser  Asn Cys Val 
    1520                 1525                 1530             


Gln Gln  His Ala Trp Asp Arg  Ser Leu Ser Val His  Pro Leu Ser 
    1535                 1540                 1545             


Met Leu  Leu Ser Gly Ile Val  Asp Pro Ala Val Met  Gly Gly Phe 
    1550                 1555                 1560             


Ser Asn  Tyr Glu Lys Ala Phe  Phe Thr Glu Lys Tyr  Leu Gln Glu 
    1565                 1570                 1575             


His Pro  Glu Asp Gln Glu Lys  Val Glu Leu Leu Lys  Arg Leu Ile 
    1580                 1585                 1590             


Ala Leu  Gln Met Pro Leu Leu  Thr Glu Gly Ile Arg  Ile His Gly 
    1595                 1600                 1605             


Glu Lys  Leu Thr Glu Gln Leu  Lys Pro Leu His Glu  Arg Leu Ser 
    1610                 1615                 1620             


Ser Cys  Phe Arg Glu Leu Lys  Glu Lys Val Glu Lys  His Tyr Gly 
    1625                 1630                 1635             


Val Ile  Thr Leu Pro Pro Asn  Leu Thr Glu Arg Lys  Gln Ser Arg 
    1640                 1645                 1650             


Thr Gly  Ser Ile Val Leu Pro  Tyr Ile Met Ser Ser  Thr Leu Arg 
    1655                 1660                 1665             


Arg Leu  Ser Ile Thr Ser Val  Thr Ser Ser Val Val  Ser Thr Ser 
    1670                 1675                 1680             


Ser Asn  Ser Ser Asp Asn Ala  Pro Ser Arg Pro Gly  Ser Asp Gly 
    1685                 1690                 1695             


Ser Ile  Leu Glu Pro Leu Leu  Glu Arg Arg Ala Ser  Ser Gly Ala 
    1700                 1705                 1710             


Arg Val  Glu Asp Leu Ser Leu  Arg Glu Glu Asn Ser  Glu Asn Arg 
    1715                 1720                 1725             


Ile Ser  Lys Phe Lys Arg Lys  Asp Trp Ser Leu Ser  Lys Ser Gln 
    1730                 1735                 1740             


Val Ile  Ala Glu Lys Ala Pro  Glu Pro Asp Leu Met  Ser Pro Thr 
    1745                 1750                 1755             


Arg Lys  Ala Gln Arg Pro Lys  Ser Leu Gln Leu Met  Asp Asn Arg 
    1760                 1765                 1770             


Leu Ser  Pro Phe His Gly Ser  Ser Pro Pro Gln Ser  Thr Pro Leu 
    1775                 1780                 1785             


Ser Pro  Pro Pro Leu Thr Pro  Lys Ala Thr Arg Thr  Leu Ser Ser 
    1790                 1795                 1800             


Pro Ser  Leu Gln Thr Asp Gly  Ile Ala Ala Thr Pro  Val Pro Pro 
    1805                 1810                 1815             


Pro Pro  Pro Pro Lys Ser Lys  Pro Tyr Glu Gly Ser  Gln Arg Asn 
    1820                 1825                 1830             


Ser Thr  Glu Leu Ala Pro Pro  Leu Pro Val Arg Arg  Glu Ala Lys 
    1835                 1840                 1845             


Ala Pro  Pro Pro Pro Pro Pro  Lys Ala Arg Lys Ser  Gly Ile Pro 
    1850                 1855                 1860             


Thr Ser  Glu Pro Gly Ser Gln  
    1865                 1870 


<210>  109
<211>  604
<212>  PRT
<213>  Homo sapiens;

<400>  109

Met Ala Arg Ile Ser Phe Ser Tyr Leu Cys Pro Ala Ser Trp Tyr Phe 
1               5                   10                  15      


Thr Val Pro Thr Val Ser Pro Phe Leu Arg Gln Arg Val Ala Phe Leu 
            20                  25                  30          


Gly Leu Phe Phe Ile Ser Cys Leu Leu Leu Leu Met Leu Ile Ile Asp 
        35                  40                  45              


Phe Arg His Trp Ser Ala Ser Leu Pro Arg Asp Arg Gln Tyr Glu Arg 
    50                  55                  60                  


Tyr Leu Ala Arg Val Gly Glu Leu Glu Ala Thr Asp Thr Glu Asp Pro 
65                  70                  75                  80  


Asn Leu Asn Tyr Gly Leu Val Val Asp Cys Gly Ser Ser Gly Ser Arg 
                85                  90                  95      


Ile Phe Val Tyr Phe Trp Pro Arg His Asn Gly Asn Pro His Asp Leu 
            100                 105                 110         


Leu Asp Ile Lys Gln Met Arg Asp Arg Asn Ser Gln Pro Val Val Lys 
        115                 120                 125             


Lys Ile Lys Pro Gly Ile Ser Ala Met Ala Asp Thr Pro Glu His Ala 
    130                 135                 140                 


Ser Asp Tyr Leu Arg Pro Leu Leu Ser Phe Ala Ala Ala His Val Pro 
145                 150                 155                 160 


Val Lys Lys His Lys Glu Thr Pro Leu Tyr Ile Leu Cys Thr Ala Gly 
                165                 170                 175     


Met Arg Leu Leu Pro Glu Arg Lys Gln Leu Ala Ile Leu Ala Asp Leu 
            180                 185                 190         


Val Lys Asp Leu Pro Leu Glu Phe Asp Phe Leu Phe Ser Gln Ser Gln 
        195                 200                 205             


Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val Tyr Ala Trp Ile Gly 
    210                 215                 220                 


Ile Asn Phe Val Leu Gly Arg Phe Asp His Glu Asp Glu Ser Asp Ala 
225                 230                 235                 240 


Glu Ala Thr Gln Glu Leu Ala Ala Gly Arg Arg Arg Thr Val Gly Ile 
                245                 250                 255     


Leu Asp Met Gly Gly Ala Ser Leu Gln Ile Ala Tyr Glu Val Pro Thr 
            260                 265                 270         


Ser Thr Ser Val Leu Pro Ala Lys Gln Glu Glu Ala Ala Lys Ile Leu 
        275                 280                 285             


Leu Ala Glu Phe Asn Leu Gly Cys Asp Val Gln His Thr Glu His Val 
    290                 295                 300                 


Tyr Arg Val Tyr Val Thr Thr Phe Leu Gly Phe Gly Gly Asn Phe Ala 
305                 310                 315                 320 


Arg Gln Arg Tyr Glu Asp Leu Val Leu Asn Glu Thr Leu Asn Lys Asn 
                325                 330                 335     


Arg Leu Leu Gly Gln Lys Thr Gly Leu Ser Pro Asp Asn Pro Phe Leu 
            340                 345                 350         


Asp Pro Cys Leu Pro Val Gly Leu Thr Asp Val Val Glu Arg Asn Ser 
        355                 360                 365             


Gln Val Leu His Val Arg Gly Arg Gly Asp Trp Val Ser Cys Gly Ala 
    370                 375                 380                 


Met Leu Ser Pro Leu Leu Ala Arg Ser Asn Thr Ser Gln Ala Ser Leu 
385                 390                 395                 400 


Asn Gly Ile Tyr Gln Ser Pro Ile Asp Phe Asn Asn Ser Glu Phe Tyr 
                405                 410                 415     


Gly Phe Ser Glu Phe Phe Tyr Cys Thr Glu Asp Val Leu Arg Ile Gly 
            420                 425                 430         


Gly Arg Tyr His Gly Pro Thr Phe Ala Lys Ala Ala Gln Asp Tyr Cys 
        435                 440                 445             


Gly Met Ala Trp Ser Val Leu Thr Gln Arg Phe Lys Asn Gly Leu Phe 
    450                 455                 460                 


Ser Ser His Ala Asp Glu His Arg Leu Lys Tyr Gln Cys Phe Lys Ser 
465                 470                 475                 480 


Ala Trp Met Tyr Gln Val Leu His Glu Gly Phe His Phe Pro Tyr Asp 
                485                 490                 495     


Tyr Pro Asn Leu Arg Thr Ala Gln Leu Val Tyr Asp Arg Glu Val Gln 
            500                 505                 510         


Trp Thr Leu Gly Ala Ile Leu Tyr Lys Thr Arg Phe Leu Pro Leu Arg 
        515                 520                 525             


Asp Leu Arg Gln Glu Gly Val Arg Gln Ala His Gly Ser Trp Phe Arg 
    530                 535                 540                 


Leu Ser Phe Val Tyr Asn His Tyr Leu Phe Phe Ala Cys Ile Leu Val 
545                 550                 555                 560 


Val Leu Leu Ala Ile Phe Leu Tyr Leu Leu Arg Leu Arg Arg Ile His 
                565                 570                 575     


His Arg Gln Thr Arg Ala Ser Ala Pro Leu Asp Leu Leu Trp Leu Glu 
            580                 585                 590         


Glu Val Val Pro Met Met Gly Val Gln Val Gly Pro 
        595                 600                 


<210>  110
<211>  987
<212>  PRT
<213>  Homo sapiens;

<400>  110

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His 
                885                 890                 895     


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val 
            900                 905                 910         


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe 
        915                 920                 925             


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala 
    930                 935                 940                 


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys 
945                 950                 955                 960 


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr 
                965                 970                 975     


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr 
            980                 985         


<210>  111
<211>  919
<212>  PRT
<213>  Homo sapiens;

<400>  111

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


<210>  112
<211>  928
<212>  PRT
<213>  Homo sapiens;

<400>  112

Met Gly Gly Ser Ala Ser Ser Gln Leu Asp Glu Gly Lys Cys Ala Tyr 
1               5                   10                  15      


Ile Arg Gly Lys Thr Glu Ala Ala Ile Lys Asn Phe Ser Pro Tyr Tyr 
            20                  25                  30          


Ser Arg Gln Tyr Ser Val Ala Phe Cys Asn His Val Arg Thr Glu Val 
        35                  40                  45              


Glu Gln Gln Arg Asp Leu Thr Ser Gln Phe Leu Lys Thr Lys Pro Pro 
    50                  55                  60                  


Leu Ala Pro Gly Thr Ile Leu Tyr Glu Ala Glu Leu Ser Gln Phe Ser 
65                  70                  75                  80  


Glu Asp Ile Lys Lys Trp Lys Glu Arg Tyr Val Val Val Lys Asn Asp 
                85                  90                  95      


Tyr Ala Val Glu Ser Tyr Glu Asn Lys Glu Ala Tyr Gln Arg Gly Ala 
            100                 105                 110         


Ala Pro Lys Cys Arg Ile Leu Pro Ala Gly Gly Lys Val Leu Thr Ser 
        115                 120                 125             


Glu Asp Glu Tyr Asn Leu Leu Ser Asp Arg His Phe Pro Asp Pro Leu 
    130                 135                 140                 


Ala Ser Ser Glu Lys Glu Asn Thr Gln Pro Phe Val Val Leu Pro Lys 
145                 150                 155                 160 


Glu Phe Pro Val Tyr Leu Trp Gln Pro Phe Phe Arg His Gly Tyr Phe 
                165                 170                 175     


Cys Phe His Glu Ala Ala Asp Gln Lys Arg Phe Ser Ala Leu Leu Ser 
            180                 185                 190         


Asp Cys Val Arg His Leu Asn His Asp Tyr Met Lys Gln Met Thr Phe 
        195                 200                 205             


Glu Ala Gln Ala Phe Leu Glu Ala Val Gln Phe Phe Arg Gln Glu Lys 
    210                 215                 220                 


Gly His Tyr Gly Ser Trp Glu Met Ile Thr Gly Asp Glu Ile Gln Ile 
225                 230                 235                 240 


Leu Ser Asn Leu Val Met Glu Glu Leu Leu Pro Thr Leu Gln Thr Asp 
                245                 250                 255     


Leu Leu Pro Lys Met Lys Gly Lys Lys Asn Asp Arg Lys Arg Thr Trp 
            260                 265                 270         


Leu Gly Leu Leu Glu Glu Ala Tyr Thr Leu Val Gln His Gln Val Ser 
        275                 280                 285             


Glu Gly Leu Ser Ala Leu Lys Glu Glu Cys Arg Ala Leu Thr Lys Gly 
    290                 295                 300                 


Leu Glu Gly Thr Ile Arg Ser Asp Met Asp Gln Ile Val Asn Ser Lys 
305                 310                 315                 320 


Asn Tyr Leu Ile Gly Lys Ile Lys Ala Met Val Ala Gln Pro Ala Glu 
                325                 330                 335     


Lys Ser Cys Leu Glu Ser Val Gln Pro Phe Leu Ala Ser Ile Leu Glu 
            340                 345                 350         


Glu Leu Met Gly Pro Val Ser Ser Gly Phe Ser Glu Val Arg Val Leu 
        355                 360                 365             


Phe Glu Lys Glu Val Asn Glu Val Ser Gln Asn Phe Gln Thr Thr Lys 
    370                 375                 380                 


Asp Ser Val Gln Leu Lys Glu His Leu Asp Arg Leu Met Asn Leu Pro 
385                 390                 395                 400 


Leu His Ser Val Lys Met Glu Pro Cys Tyr Thr Lys Val Asn Leu Leu 
                405                 410                 415     


His Glu Arg Leu Gln Asp Leu Lys Ser Arg Phe Arg Phe Pro His Ile 
            420                 425                 430         


Asp Leu Val Val Gln Arg Thr Gln Asn Tyr Met Gln Glu Leu Met Glu 
        435                 440                 445             


Asn Ala Val Phe Thr Phe Glu Gln Leu Leu Ser Pro His Leu Gln Gly 
    450                 455                 460                 


Glu Ala Ser Lys Thr Ala Val Ala Ile Glu Lys Val Lys Leu Arg Val 
465                 470                 475                 480 


Leu Lys Gln Tyr Asp Tyr Asp Ser Ser Thr Ile Arg Lys Lys Ile Phe 
                485                 490                 495     


Gln Glu Ala Leu Val Gln Ile Thr Leu Pro Thr Val Gln Lys Ala Leu 
            500                 505                 510         


Ala Ser Thr Cys Lys Pro Glu Leu Gln Lys Tyr Glu Gln Phe Ile Phe 
        515                 520                 525             


Ala Asp His Thr Asn Met Ile His Val Glu Asn Val Tyr Glu Glu Ile 
    530                 535                 540                 


Leu His Gln Ile Leu Leu Asp Glu Thr Leu Lys Val Ile Lys Glu Ala 
545                 550                 555                 560 


Ala Ile Leu Lys Lys His Asn Leu Phe Glu Asp Asn Met Ala Leu Pro 
                565                 570                 575     


Ser Glu Ser Val Ser Ser Leu Thr Asp Leu Lys Pro Pro Thr Gly Ser 
            580                 585                 590         


Asn Gln Ala Ser Pro Ala Arg Arg Ala Ser Ala Ile Leu Pro Gly Val 
        595                 600                 605             


Leu Gly Ser Glu Thr Leu Ser Asn Glu Val Phe Gln Glu Ser Glu Glu 
    610                 615                 620                 


Glu Lys Gln Pro Glu Val Pro Ser Ser Leu Ala Lys Gly Glu Ser Leu 
625                 630                 635                 640 


Ser Leu Pro Gly Pro Ser Pro Pro Pro Asp Gly Thr Glu Gln Val Ile 
                645                 650                 655     


Ile Ser Arg Val Asp Asp Pro Val Val Asn Pro Val Ala Thr Glu Asp 
            660                 665                 670         


Thr Ala Gly Leu Pro Gly Thr Cys Ser Ser Glu Leu Glu Phe Gly Gly 
        675                 680                 685             


Thr Leu Glu Asp Glu Glu Pro Ala Gln Glu Glu Pro Glu Pro Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Leu Lys Ala Leu Arg Lys Leu Leu Thr Ala Ser Val 
705                 710                 715                 720 


Glu Val Pro Val Asp Ser Ala Pro Val Met Glu Glu Asp Thr Asn Gly 
                725                 730                 735     


Glu Ser His Val Pro Gln Glu Asn Glu Glu Glu Glu Glu Lys Glu Pro 
            740                 745                 750         


Ser Gln Ala Ala Ala Ile His Pro Asp Asn Cys Glu Glu Ser Glu Val 
        755                 760                 765             


Ser Glu Arg Glu Ala Gln Pro Pro Cys Pro Glu Ala His Gly Glu Glu 
    770                 775                 780                 


Leu Gly Gly Phe Pro Glu Val Gly Ser Pro Ala Ser Pro Pro Ala Ser 
785                 790                 795                 800 


Gly Gly Leu Thr Glu Glu Pro Leu Gly Pro Met Glu Gly Glu Leu Pro 
                805                 810                 815     


Gly Glu Ala Cys Thr Leu Thr Ala His Glu Gly Arg Gly Gly Lys Cys 
            820                 825                 830         


Thr Glu Glu Gly Asp Ala Ser Gln Gln Glu Gly Cys Thr Leu Gly Ser 
        835                 840                 845             


Asp Pro Ile Cys Leu Ser Glu Ser Gln Val Ser Glu Glu Gln Glu Glu 
    850                 855                 860                 


Met Gly Gly Gln Ser Ser Ala Ala Gln Ala Thr Ala Ser Val Asn Ala 
865                 870                 875                 880 


Glu Glu Ile Lys Val Ala Arg Ile His Glu Cys Gln Trp Val Val Glu 
                885                 890                 895     


Asp Ala Pro Asn Pro Asp Val Leu Leu Ser His Lys Asp Asp Val Lys 
            900                 905                 910         


Glu Gly Glu Gly Gly Gln Glu Ser Phe Pro Glu Leu Pro Ser Glu Glu 
        915                 920                 925             


<210>  113
<211>  368
<212>  PRT
<213>  Homo sapiens;

<400>  113

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu 
                165                 170                 175     


Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg 
            180                 185                 190         


Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met 
        195                 200                 205             


Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro 
    210                 215                 220                 


Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly 
225                 230                 235                 240 


Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro 
                245                 250                 255     


Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly 
            260                 265                 270         


Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys 
        275                 280                 285             


Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu 
    290                 295                 300                 


Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu 
305                 310                 315                 320 


Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser 
                325                 330                 335     


Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr 
            340                 345                 350         


Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
        355                 360                 365             


<210>  114
<211>  907
<212>  PRT
<213>  Homo sapiens;

<400>  114

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Met Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Ser 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ser 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  115
<211>  622
<212>  PRT
<213>  Homo sapiens;

<400>  115

Met Gly Leu Tyr Gly Gln Ala Cys Pro Ser Val Thr Ser Leu Arg Met 
1               5                   10                  15      


Thr Ser Glu Leu Glu Ser Ser Leu Thr Ser Met Asp Trp Leu Pro Gln 
            20                  25                  30          


Leu Thr Met Arg Ala Ala Ile Gln Lys Ser Asp Ala Thr Gln Asn Ala 
        35                  40                  45              


His Gly Thr Gly Ile Ser Lys Lys Asn Ala Leu Leu Asp Pro Asn Thr 
    50                  55                  60                  


Thr Leu Asp Gln Glu Glu Val Gln Gln His Lys Asp Gly Lys Pro Pro 
65                  70                  75                  80  


Tyr Ser Tyr Ala Ser Leu Ile Thr Phe Ala Ile Asn Ser Ser Pro Lys 
                85                  90                  95      


Lys Lys Met Thr Leu Ser Glu Ile Tyr Gln Trp Ile Cys Asp Asn Phe 
            100                 105                 110         


Pro Tyr Tyr Arg Glu Ala Gly Ser Gly Trp Lys Asn Ser Ile Arg His 
        115                 120                 125             


Asn Leu Ser Leu Asn Lys Cys Phe Leu Lys Val Pro Arg Ser Lys Asp 
    130                 135                 140                 


Asp Pro Gly Lys Gly Ser Tyr Trp Ala Ile Asp Thr Asn Pro Lys Glu 
145                 150                 155                 160 


Asp Val Leu Pro Thr Arg Pro Lys Lys Arg Ala Arg Ser Val Glu Arg 
                165                 170                 175     


Ala Ser Thr Pro Tyr Ser Ile Asp Ser Asp Ser Leu Gly Met Glu Cys 
            180                 185                 190         


Ile Ile Ser Gly Ser Ala Ser Pro Thr Leu Ala Ile Asn Thr Val Thr 
        195                 200                 205             


Asn Lys Val Thr Leu Tyr Asn Thr Asp Gln Asp Gly Ser Asp Ser Pro 
    210                 215                 220                 


Arg Ser Ser Leu Asn Asn Ser Leu Ser Asp Gln Ser Leu Ala Ser Val 
225                 230                 235                 240 


Asn Leu Asn Ser Val Gly Ser Val His Ser Tyr Thr Pro Val Thr Ser 
                245                 250                 255     


His Pro Glu Ser Val Ser Gln Ser Leu Thr Pro Gln Gln Gln Pro Gln 
            260                 265                 270         


Tyr Asn Leu Pro Glu Arg Asp Lys Gln Leu Leu Phe Ser Glu Tyr Asn 
        275                 280                 285             


Phe Glu Asp Leu Ser Ala Ser Phe Arg Ser Leu Tyr Lys Ser Val Phe 
    290                 295                 300                 


Glu Gln Ser Leu Ser Gln Gln Gly Leu Met Asn Ile Pro Ser Glu Ser 
305                 310                 315                 320 


Ser Gln Gln Ser His Thr Ser Cys Thr Tyr Gln His Ser Pro Ser Ser 
                325                 330                 335     


Thr Val Ser Thr His Pro His Ser Asn Gln Ser Ser Leu Ser Asn Ser 
            340                 345                 350         


His Gly Ser Gly Leu Asn Thr Thr Gly Ser Asn Ser Val Ala Gln Val 
        355                 360                 365             


Ser Leu Ser His Pro Gln Met His Thr Gln Pro Ser Pro His Pro Pro 
    370                 375                 380                 


His Arg Pro His Gly Leu Pro Gln His Pro Gln Arg Ser Pro His Pro 
385                 390                 395                 400 


Ala Pro His Pro Gln Gln His Ser Gln Leu Gln Ser Pro His Pro Gln 
                405                 410                 415     


His Pro Ser Pro His Gln His Ile Gln His His Pro Asn His Gln His 
            420                 425                 430         


Gln Thr Leu Thr His Gln Ala Pro Pro Pro Pro Gln Gln Val Ser Cys 
        435                 440                 445             


Asn Ser Gly Val Ser Asn Asp Trp Tyr Ala Thr Leu Asp Met Leu Lys 
    450                 455                 460                 


Glu Ser Cys Arg Ile Ala Ser Ser Val Asn Trp Ser Asp Val Asp Leu 
465                 470                 475                 480 


Ser Gln Phe Gln Gly Leu Met Glu Ser Met Arg Gln Ala Asp Leu Lys 
                485                 490                 495     


Asn Trp Ser Leu Asp Gln Val Gln Phe Ala Asp Leu Cys Ser Ser Leu 
            500                 505                 510         


Asn Gln Phe Phe Thr Gln Thr Gly Leu Ile His Ser Gln Ser Asn Val 
        515                 520                 525             


Gln Gln Asn Val Cys His Gly Ala Met His Pro Thr Lys Pro Ser Gln 
    530                 535                 540                 


His Ile Gly Thr Gly Asn Leu Tyr Ile Asp Ser Arg Gln Asn Leu Pro 
545                 550                 555                 560 


Pro Ser Val Met Pro Pro Pro Gly Tyr Pro His Ile Pro Gln Ala Leu 
                565                 570                 575     


Ser Thr Pro Gly Thr Thr Met Ala Gly His His Arg Ala Met Asn Gln 
            580                 585                 590         


Gln His Met Met Pro Ser Gln Ala Phe Gln Met Arg Arg Ser Leu Pro 
        595                 600                 605             


Pro Asp Asp Ile Gln Asp Asp Phe Asp Trp Asp Ser Ile Val 
    610                 615                 620         


<210>  116
<211>  638
<212>  PRT
<213>  Homo sapiens;

<400>  116

Met Ser Gly Asp Pro Asp Val Leu Glu Tyr Tyr Lys Asn Asp His Ser 
1               5                   10                  15      


Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn Phe Cys Glu Gln Val Asp 
            20                  25                  30          


Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu Gln Asp Ser Phe Val Phe 
        35                  40                  45              


Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr Leu Val Ala Glu Thr Glu 
    50                  55                  60                  


Glu Asp Met Asn Lys Trp Val Gln Ser Ile Cys Gln Ile Cys Gly Phe 
65                  70                  75                  80  


Asn Gln Ala Glu Glu Ser Thr Asp Ser Leu Arg Asn Val Ser Ser Ala 
                85                  90                  95      


Gly His Gly Pro Arg Ser Ser Pro Ala Glu Leu Ser Ser Ser Ser Gln 
            100                 105                 110         


His Leu Leu Arg Glu Arg Lys Ser Ser Ala Pro Ser His Ser Ser Gln 
        115                 120                 125             


Pro Thr Leu Phe Thr Phe Glu Pro Pro Val Ser Asn His Met Gln Pro 
    130                 135                 140                 


Thr Leu Ser Thr Ser Ala Pro Gln Glu Tyr Leu Tyr Leu His Gln Cys 
145                 150                 155                 160 


Ile Ser Arg Arg Ala Glu Asn Ala Arg Ser Ala Ser Phe Ser Gln Gly 
                165                 170                 175     


Thr Arg Ala Ser Phe Leu Met Arg Ser Asp Thr Ala Val Gln Lys Leu 
            180                 185                 190         


Ala Gln Gly Asn Gly His Cys Val Asn Gly Ile Ser Gly Gln Val His 
        195                 200                 205             


Gly Phe Tyr Ser Leu Pro Lys Pro Ser Arg His Asn Thr Glu Phe Arg 
    210                 215                 220                 


Asp Ser Thr Tyr Asp Leu Pro Arg Ser Leu Ala Ser His Gly His Thr 
225                 230                 235                 240 


Lys Gly Ser Leu Thr Gly Ser Glu Thr Asp Asn Glu Asp Val Tyr Thr 
                245                 250                 255     


Phe Lys Thr Pro Ser Asn Thr Leu Cys Arg Glu Phe Gly Asp Leu Leu 
            260                 265                 270         


Val Asp Asn Met Asp Val Pro Ala Thr Pro Leu Ser Ala Tyr Gln Ile 
        275                 280                 285             


Pro Arg Thr Phe Thr Leu Asp Lys Asn His Asn Ala Met Thr Val Ala 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ala Ile Ala Pro Pro Pro Arg Pro Pro Lys Pro 
305                 310                 315                 320 


Ser Gln Ala Glu Thr Pro Arg Trp Gly Ser Pro Gln Gln Arg Pro Pro 
                325                 330                 335     


Ile Ser Glu Asn Ser Arg Ser Val Ala Ala Thr Ile Pro Arg Arg Asn 
            340                 345                 350         


Thr Leu Pro Ala Met Asp Asn Ser Arg Leu His Arg Ala Ser Ser Cys 
        355                 360                 365             


Glu Thr Tyr Glu Tyr Pro Gln Arg Gly Gly Glu Ser Ala Gly Arg Ser 
    370                 375                 380                 


Ala Glu Ser Met Ser Asp Gly Val Gly Ser Phe Leu Pro Gly Lys Met 
385                 390                 395                 400 


Ile Val Gly Arg Ser Asp Ser Thr Asn Ser Glu Asp Asn Tyr Val Pro 
                405                 410                 415     


Met Asn Pro Gly Ser Ser Thr Leu Leu Ala Met Glu Arg Ala Gly Asp 
            420                 425                 430         


Asn Ser Gln Ser Val Tyr Ile Pro Met Ser Pro Gly Ala His His Phe 
        435                 440                 445             


Asp Ser Leu Gly Tyr Pro Ser Thr Thr Leu Pro Val His Arg Gly Pro 
    450                 455                 460                 


Ser Arg Gly Ser Glu Ile Gln Pro Pro Pro Val Asn Arg Asn Leu Lys 
465                 470                 475                 480 


Pro Asp Arg Lys Ala Lys Pro Thr Pro Leu Asp Leu Arg Asn Asn Thr 
                485                 490                 495     


Val Ile Asp Glu Leu Pro Phe Lys Ser Pro Ile Thr Lys Ser Trp Ser 
            500                 505                 510         


Arg Ala Asn His Thr Phe Asn Ser Ser Ser Ser Gln Tyr Cys Arg Pro 
        515                 520                 525             


Ile Ser Thr Gln Ser Ile Thr Ser Thr Asp Ser Gly Asp Ser Glu Glu 
    530                 535                 540                 


Asn Tyr Val Pro Met Gln Asn Pro Val Ser Ala Ser Pro Val Pro Ser 
545                 550                 555                 560 


Gly Thr Asn Ser Pro Ala Pro Lys Lys Ser Thr Gly Ser Val Asp Tyr 
                565                 570                 575     


Leu Ala Leu Asp Phe Gln Pro Ser Ser Pro Ser Pro His Arg Lys Pro 
            580                 585                 590         


Ser Thr Ser Ser Val Thr Ser Asp Glu Lys Val Asp Tyr Val Gln Val 
        595                 600                 605             


Asp Lys Glu Lys Thr Gln Ala Leu Gln Asn Thr Met Gln Glu Trp Thr 
    610                 615                 620                 


Asp Val Arg Gln Ser Ser Glu Pro Ser Lys Gly Ala Lys Leu 
625                 630                 635             


<210>  117
<211>  571
<212>  PRT
<213>  Homo sapiens;

<400>  117

Met Arg Arg Arg Ser Arg Met Leu Leu Cys Phe Ala Phe Leu Trp Val 
1               5                   10                  15      


Leu Gly Ile Ala Tyr Tyr Met Tyr Ser Gly Gly Gly Ser Ala Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Ala Gly Arg Lys Glu Asp Trp Asn Glu Ile 
        35                  40                  45              


Asp Pro Ile Lys Lys Lys Asp Leu His His Ser Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Gln Ser Met Glu Thr Leu Pro Pro Gly Lys Val Arg Trp Pro Asp 
65                  70                  75                  80  


Phe Asn Gln Glu Ala Tyr Val Gly Gly Thr Met Val Arg Ser Gly Gln 
                85                  90                  95      


Asp Pro Tyr Ala Arg Asn Lys Phe Asn Gln Val Glu Ser Asp Lys Leu 
            100                 105                 110         


Arg Met Asp Arg Ala Ile Pro Asp Thr Arg His Asp Gln Cys Gln Arg 
        115                 120                 125             


Lys Gln Trp Arg Val Asp Leu Pro Ala Thr Ser Val Val Ile Thr Phe 
    130                 135                 140                 


His Asn Glu Ala Arg Ser Ala Leu Leu Arg Thr Val Val Ser Val Leu 
145                 150                 155                 160 


Lys Lys Ser Pro Pro His Leu Ile Lys Glu Ile Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asn Asp Pro Glu Asp Gly Ala Leu Leu Gly Lys Ile Glu Lys 
            180                 185                 190         


Val Arg Val Leu Arg Asn Asp Arg Arg Glu Gly Leu Met Arg Ser Arg 
        195                 200                 205             


Val Arg Gly Ala Asp Ala Ala Gln Ala Lys Val Leu Thr Phe Leu Asp 
    210                 215                 220                 


Ser His Cys Glu Cys Asn Glu His Trp Leu Glu Pro Leu Leu Glu Arg 
225                 230                 235                 240 


Val Ala Glu Asp Arg Thr Arg Val Val Ser Pro Ile Ile Asp Val Ile 
                245                 250                 255     


Asn Met Asp Asn Phe Gln Tyr Val Gly Ala Ser Ala Asp Leu Lys Gly 
            260                 265                 270         


Gly Phe Asp Trp Asn Leu Val Phe Lys Trp Asp Tyr Met Thr Pro Glu 
        275                 280                 285             


Gln Arg Arg Ser Arg Gln Gly Asn Pro Val Ala Pro Ile Lys Thr Pro 
    290                 295                 300                 


Met Ile Ala Gly Gly Leu Phe Val Met Asp Lys Phe Tyr Phe Glu Glu 
305                 310                 315                 320 


Leu Gly Lys Tyr Asp Met Met Met Asp Val Trp Gly Gly Glu Asn Leu 
                325                 330                 335     


Glu Ile Ser Phe Arg Val Trp Gln Cys Gly Gly Ser Leu Glu Ile Ile 
            340                 345                 350         


Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Gln His Pro Tyr Thr 
        355                 360                 365             


Phe Pro Gly Gly Ser Gly Thr Val Phe Ala Arg Asn Thr Arg Arg Ala 
    370                 375                 380                 


Ala Glu Val Trp Met Asp Glu Tyr Lys Asn Phe Tyr Tyr Ala Ala Val 
385                 390                 395                 400 


Pro Ser Ala Arg Asn Val Pro Tyr Gly Asn Ile Gln Ser Arg Leu Glu 
                405                 410                 415     


Leu Arg Lys Lys Leu Ser Cys Lys Pro Phe Lys Trp Tyr Leu Glu Asn 
            420                 425                 430         


Val Tyr Pro Glu Leu Arg Val Pro Asp His Gln Asp Ile Ala Phe Gly 
        435                 440                 445             


Ala Leu Gln Gln Gly Thr Asn Cys Leu Asp Thr Leu Gly His Phe Ala 
    450                 455                 460                 


Asp Gly Val Val Gly Val Tyr Glu Cys His Asn Ala Gly Gly Asn Gln 
465                 470                 475                 480 


Glu Trp Ala Leu Thr Lys Glu Lys Ser Val Lys His Met Asp Leu Cys 
                485                 490                 495     


Leu Thr Val Val Asp Arg Ala Pro Gly Ser Leu Ile Lys Leu Gln Gly 
            500                 505                 510         


Cys Arg Glu Asn Asp Ser Arg Gln Lys Trp Glu Gln Ile Glu Gly Asn 
        515                 520                 525             


Ser Lys Leu Arg His Val Gly Ser Asn Leu Cys Leu Asp Ser Arg Thr 
    530                 535                 540                 


Ala Lys Ser Gly Gly Leu Ser Val Glu Val Cys Gly Pro Ala Leu Ser 
545                 550                 555                 560 


Gln Gln Trp Lys Phe Thr Leu Asn Leu Gln Gln 
                565                 570     


<210>  118
<211>  336
<212>  PRT
<213>  Homo sapiens;

<400>  118

Met Ser Asn Met Glu Asn Ser Phe Asp Asp Val Ser Cys Leu Ser Pro 
1               5                   10                  15      


Gln Asn Leu Gly Ser Ser Ser Pro Ser Lys Lys Gln Ser Lys Glu Asn 
            20                  25                  30          


Thr Ile Thr Ile Asn Cys Val Thr Phe Pro His Pro Asp Thr Met Pro 
        35                  40                  45              


Glu Gln Gln Leu Leu Lys Pro Thr Glu Trp Ser Tyr Cys Asp Tyr Phe 
    50                  55                  60                  


Trp Ala Asp Lys Lys Asp Pro Gln Gly Asn Gly Thr Val Ala Gly Phe 
65                  70                  75                  80  


Glu Leu Leu Leu Gln Lys Gln Leu Lys Gly Lys Gln Met Gln Lys Glu 
                85                  90                  95      


Met Ser Glu Phe Ile Arg Glu Arg Ile Lys Ile Glu Glu Asp Tyr Ala 
            100                 105                 110         


Lys Asn Leu Ala Lys Leu Ser Gln Asn Ser Leu Ala Ser Gln Glu Glu 
        115                 120                 125             


Gly Ser Leu Gly Glu Ala Trp Ala Gln Val Lys Lys Ser Leu Ala Asp 
    130                 135                 140                 


Glu Ala Glu Val His Leu Lys Phe Ser Ala Lys Leu His Ser Glu Val 
145                 150                 155                 160 


Glu Lys Pro Leu Met Asn Phe Arg Glu Asn Phe Lys Lys Asp Met Lys 
                165                 170                 175     


Lys Cys Asp His His Ile Ala Asp Leu Arg Lys Gln Leu Ala Ser Arg 
            180                 185                 190         


Tyr Ala Ser Val Glu Lys Ala Arg Lys Ala Leu Thr Glu Arg Gln Arg 
        195                 200                 205             


Asp Leu Glu Met Lys Thr Gln Gln Leu Glu Ile Lys Leu Ser Asn Lys 
    210                 215                 220                 


Thr Glu Glu Asp Ile Lys Lys Ala Arg Arg Lys Ser Thr Gln Ala Gly 
225                 230                 235                 240 


Asp Asp Leu Met Arg Cys Val Asp Leu Tyr Asn Gln Ala Gln Ser Lys 
                245                 250                 255     


Trp Phe Glu Glu Met Val Thr Thr Thr Leu Glu Leu Glu Arg Leu Glu 
            260                 265                 270         


Val Glu Arg Val Glu Met Ile Arg Gln His Leu Cys Gln Tyr Thr Gln 
        275                 280                 285             


Leu Arg His Glu Thr Asp Met Phe Asn Gln Ser Thr Val Glu Pro Val 
    290                 295                 300                 


Asp Gln Leu Leu Arg Lys Val Asp Pro Ala Lys Asp Arg Glu Leu Trp 
305                 310                 315                 320 


Val Arg Glu His Lys Thr Gly Asn Ile Arg Pro Val Asp Met Glu Ile 
                325                 330                 335     


<210>  119
<211>  1684
<212>  PRT
<213>  Homo sapiens;

<400>  119

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys 
            20                  25                  30          


Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys 
        35                  40                  45              


Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr 
    50                  55                  60                  


Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys 
                85                  90                  95      


Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys 
            100                 105                 110         


Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val 
        115                 120                 125             


Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys 
    130                 135                 140                 


Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met 
145                 150                 155                 160 


Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser 
                165                 170                 175     


Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro 
            180                 185                 190         


Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr 
        195                 200                 205             


Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu 
    210                 215                 220                 


Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met 
                245                 250                 255     


Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys 
            260                 265                 270         


Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu 
        275                 280                 285             


Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys 
    290                 295                 300                 


Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu 
305                 310                 315                 320 


Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His 
                325                 330                 335     


Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys 
            340                 345                 350         


Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp 
        355                 360                 365             


Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu 
    370                 375                 380                 


Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val 
385                 390                 395                 400 


Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys 
                405                 410                 415     


Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln 
            420                 425                 430         


His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser 
        435                 440                 445             


Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu 
    450                 455                 460                 


Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr 
465                 470                 475                 480 


Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu 
                485                 490                 495     


Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln 
            500                 505                 510         


Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr 
        515                 520                 525             


Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn 
    530                 535                 540                 


Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr 
545                 550                 555                 560 


Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser 
                565                 570                 575     


Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu 
            580                 585                 590         


Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu 
        595                 600                 605             


Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile 
    610                 615                 620                 


Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu 
625                 630                 635                 640 


Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu 
                645                 650                 655     


Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln 
            660                 665                 670         


Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys 
        675                 680                 685             


Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu 
    690                 695                 700                 


Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu 
705                 710                 715                 720 


Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu 
                725                 730                 735     


Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys 
            740                 745                 750         


Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser 
        755                 760                 765             


Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln 
    770                 775                 780                 


Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu 
785                 790                 795                 800 


Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys 
                805                 810                 815     


Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu 
            820                 825                 830         


Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu 
        835                 840                 845             


Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met 
    850                 855                 860                 


Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile 
865                 870                 875                 880 


Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn 
                885                 890                 895     


Glu Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu 
            900                 905                 910         


Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu 
        915                 920                 925             


Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser 
    930                 935                 940                 


Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys 
945                 950                 955                 960 


Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys 
                965                 970                 975     


Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys 
            980                 985                 990         


Glu Glu Leu Glu Ser Leu Arg Ser  Glu Lys Asp Gln Leu  Ser Ala Ser 
        995                 1000                 1005             


Met Arg  Asp Leu Ile Gln Gly  Ala Glu Ser Tyr Lys  Asn Leu Leu 
    1010                 1015                 1020             


Leu Glu  Tyr Glu Lys Gln Ser  Glu Gln Leu Asp Val  Glu Lys Glu 
    1025                 1030                 1035             


Arg Ala  Asn Asn Phe Glu His  Arg Ile Glu Asp Leu  Thr Arg Gln 
    1040                 1045                 1050             


Leu Arg  Asn Ser Thr Leu Gln  Cys Glu Thr Ile Asn  Ser Asp Asn 
    1055                 1060                 1065             


Glu Asp  Leu Leu Ala Arg Ile  Glu Thr Leu Gln Ser  Asn Ala Lys 
    1070                 1075                 1080             


Leu Leu  Glu Val Gln Ile Leu  Glu Val Gln Arg Ala  Lys Ala Met 
    1085                 1090                 1095             


Val Asp  Lys Glu Leu Glu Ala  Glu Lys Leu Gln Lys  Glu Gln Lys 
    1100                 1105                 1110             


Ile Lys  Glu His Ala Thr Thr  Val Asn Glu Leu Glu  Glu Leu Gln 
    1115                 1120                 1125             


Val Gln  Leu Gln Lys Gln Lys  Lys Gln Leu Gln Lys  Thr Met Gln 
    1130                 1135                 1140             


Glu Leu  Glu Leu Val Lys Lys  Asp Ala Gln Gln Thr  Thr Leu Met 
    1145                 1150                 1155             


Asn Met  Glu Ile Ala Asp Tyr  Glu Arg Leu Met Lys  Glu Leu Asn 
    1160                 1165                 1170             


Gln Lys  Leu Thr Asn Lys Asn  Asn Lys Ile Glu Asp  Leu Glu Gln 
    1175                 1180                 1185             


Glu Ile  Lys Ile Gln Lys Gln  Lys Gln Glu Thr Leu  Gln Glu Glu 
    1190                 1195                 1200             


Ile Thr  Ser Leu Gln Ser Ser  Val Gln Gln Tyr Glu  Glu Lys Asn 
    1205                 1210                 1215             


Thr Lys  Ile Lys Gln Leu Leu  Val Lys Thr Lys Lys  Glu Leu Ala 
    1220                 1225                 1230             


Asp Ser  Lys Gln Ala Glu Thr  Asp His Leu Ile Leu  Gln Ala Ser 
    1235                 1240                 1245             


Leu Lys  Gly Glu Leu Glu Ala  Ser Gln Gln Gln Val  Glu Val Tyr 
    1250                 1255                 1260             


Lys Ile  Gln Leu Ala Glu Ile  Thr Ser Glu Lys His  Lys Ile His 
    1265                 1270                 1275             


Glu His  Leu Lys Thr Ser Ala  Glu Gln His Gln Arg  Thr Leu Ser 
    1280                 1285                 1290             


Ala Tyr  Gln Gln Arg Val Thr  Ala Leu Gln Glu Glu  Cys Arg Ala 
    1295                 1300                 1305             


Ala Lys  Ala Glu Gln Ala Thr  Val Thr Ser Glu Phe  Glu Ser Tyr 
    1310                 1315                 1320             


Lys Val  Arg Val His Asn Val  Leu Lys Gln Gln Lys  Asn Lys Ser 
    1325                 1330                 1335             


Met Ser  Gln Ala Glu Thr Glu  Gly Ala Lys Gln Glu  Arg Glu His 
    1340                 1345                 1350             


Leu Glu  Met Leu Ile Asp Gln  Leu Lys Ile Lys Leu  Gln Asp Ser 
    1355                 1360                 1365             


Gln Asn  Asn Leu Gln Ile Asn  Val Ser Glu Leu Gln  Thr Leu Gln 
    1370                 1375                 1380             


Ser Glu  His Asp Thr Leu Leu  Glu Arg His Asn Lys  Met Leu Gln 
    1385                 1390                 1395             


Glu Thr  Val Ser Lys Glu Ala  Glu Leu Arg Glu Lys  Leu Cys Ser 
    1400                 1405                 1410             


Ile Gln  Ser Glu Asn Met Met  Met Lys Ser Glu His  Thr Gln Thr 
    1415                 1420                 1425             


Val Ser  Gln Leu Thr Ser Gln  Asn Glu Val Leu Arg  Asn Ser Phe 
    1430                 1435                 1440             


Arg Asp  Gln Val Arg His Leu  Gln Glu Glu His Arg  Lys Thr Val 
    1445                 1450                 1455             


Glu Thr  Leu Gln Gln Gln Leu  Ser Lys Met Glu Ala  Gln Leu Phe 
    1460                 1465                 1470             


Gln Leu  Lys Asn Glu Pro Thr  Thr Arg Ser Pro Val  Ser Ser Gln 
    1475                 1480                 1485             


Gln Ser  Leu Lys Asn Leu Arg  Glu Arg Arg Asn Thr  Asp Leu Pro 
    1490                 1495                 1500             


Leu Leu  Asp Met His Thr Val  Thr Arg Glu Glu Gly  Glu Gly Met 
    1505                 1510                 1515             


Glu Thr  Thr Asp Thr Glu Ser  Val Ser Ser Ala Ser  Thr Tyr Thr 
    1520                 1525                 1530             


Gln Ser  Leu Glu Gln Leu Leu  Asn Ser Pro Glu Thr  Lys Leu Glu 
    1535                 1540                 1545             


Pro Pro  Leu Trp His Ala Glu  Phe Thr Lys Glu Glu  Leu Val Gln 
    1550                 1555                 1560             


Lys Leu  Ser Ser Thr Thr Lys  Ser Ala Asp His Leu  Asn Gly Leu 
    1565                 1570                 1575             


Leu Arg  Glu Thr Glu Ala Thr  Asn Ala Ile Leu Met  Glu Gln Ile 
    1580                 1585                 1590             


Lys Leu  Leu Lys Ser Glu Ile  Arg Arg Leu Glu Arg  Asn Gln Glu 
    1595                 1600                 1605             


Arg Glu  Lys Ser Ala Ala Asn  Leu Glu Tyr Leu Lys  Asn Val Leu 
    1610                 1615                 1620             


Leu Gln  Phe Ile Phe Leu Lys  Pro Gly Ser Glu Arg  Glu Arg Leu 
    1625                 1630                 1635             


Leu Pro  Val Ile Asn Thr Met  Leu Gln Leu Ser Pro  Glu Glu Lys 
    1640                 1645                 1650             


Gly Lys  Leu Ala Ala Val Ala  Gln Gly Glu Glu Glu  Asn Ala Ser 
    1655                 1660                 1665             


Arg Ser  Ser Gly Trp Ala Ser  Tyr Leu His Ser Trp  Ser Gly Leu 
    1670                 1675                 1680             


Arg 
    


<210>  120
<211>  590
<212>  PRT
<213>  Homo sapiens;

<400>  120

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  121
<211>  657
<212>  PRT
<213>  Homo sapiens;

<400>  121

Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro 
1               5                   10                  15      


Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val 
            20                  25                  30          


Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val 
        35                  40                  45              


Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu 
    50                  55                  60                  


Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val 
65                  70                  75                  80  


Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser 
                85                  90                  95      


Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys 
            100                 105                 110         


Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn 
        115                 120                 125             


Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys 
    130                 135                 140                 


Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys 
145                 150                 155                 160 


Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr 
                165                 170                 175     


Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg 
            180                 185                 190         


Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg 
        195                 200                 205             


Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
    210                 215                 220                 


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
225                 230                 235                 240 


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
                245                 250                 255     


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
            260                 265                 270         


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
        275                 280                 285             


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
    290                 295                 300                 


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
305                 310                 315                 320 


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
                325                 330                 335     


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
            340                 345                 350         


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
        355                 360                 365             


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
    370                 375                 380                 


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
385                 390                 395                 400 


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
                405                 410                 415     


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
            420                 425                 430         


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
        435                 440                 445             


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
    450                 455                 460                 


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
465                 470                 475                 480 


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
                485                 490                 495     


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
            500                 505                 510         


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
        515                 520                 525             


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
    530                 535                 540                 


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
545                 550                 555                 560 


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
                565                 570                 575     


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
            580                 585                 590         


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
        595                 600                 605             


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
    610                 615                 620                 


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
625                 630                 635                 640 


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
                645                 650                 655     


Leu 
    


<210>  122
<211>  486
<212>  PRT
<213>  Homo sapiens;

<400>  122

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15      


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30          


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45              


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60                  


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80  


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95      


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110         


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125             


Asp Arg Ala Asp Lys Ser Ala Val Gly Phe Asp Tyr Lys Gly Glu Val 
    130                 135                 140                 


Glu Lys His Thr Ser Gln Lys Asp Tyr Ser Arg Gly Phe Gly Gly Arg 
145                 150                 155                 160 


Tyr Gly Val Glu Lys Asp Lys Trp Asp Lys Ala Ala Leu Gly Tyr Asp 
                165                 170                 175     


Tyr Lys Gly Glu Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ala Lys 
            180                 185                 190         


Gly Phe Gly Gly Gln Tyr Gly Ile Gln Lys Asp Arg Val Asp Lys Ser 
        195                 200                 205             


Ala Val Gly Phe Asn Glu Met Glu Ala Pro Thr Thr Ala Tyr Lys Lys 
    210                 215                 220                 


Thr Thr Pro Ile Glu Ala Ala Ser Ser Gly Thr Arg Gly Leu Lys Ala 
225                 230                 235                 240 


Lys Phe Glu Ser Met Ala Glu Glu Lys Arg Lys Arg Glu Glu Glu Glu 
                245                 250                 255     


Lys Ala Gln Gln Val Ala Arg Arg Gln Gln Glu Arg Lys Ala Val Thr 
            260                 265                 270         


Lys Arg Ser Pro Glu Ala Pro Gln Pro Val Ile Ala Met Glu Glu Pro 
        275                 280                 285             


Ala Val Pro Ala Pro Leu Pro Lys Lys Ile Ser Ser Glu Ala Trp Pro 
    290                 295                 300                 


Pro Val Gly Thr Pro Pro Ser Ser Glu Ser Glu Pro Val Arg Thr Ser 
305                 310                 315                 320 


Arg Glu His Pro Val Pro Leu Leu Pro Ile Arg Gln Thr Leu Pro Glu 
                325                 330                 335     


Asp Asn Glu Glu Pro Pro Ala Leu Pro Pro Arg Thr Leu Glu Gly Leu 
            340                 345                 350         


Gln Val Glu Glu Glu Pro Val Tyr Glu Ala Glu Pro Glu Pro Glu Pro 
        355                 360                 365             


Glu Pro Glu Pro Glu Pro Glu Asn Asp Tyr Glu Asp Val Glu Glu Met 
    370                 375                 380                 


Asp Arg His Glu Gln Glu Asp Glu Pro Glu Gly Asp Tyr Glu Glu Val 
385                 390                 395                 400 


Leu Glu Pro Glu Asp Ser Ser Phe Ser Ser Ala Leu Ala Gly Ser Ser 
                405                 410                 415     


Gly Cys Pro Ala Gly Ala Gly Ala Gly Ala Val Ala Leu Gly Ile Ser 
            420                 425                 430         


Ala Val Ala Val Tyr Asp Tyr Gln Gly Glu Gly Ser Asp Glu Leu Ser 
        435                 440                 445             


Phe Asp Pro Asp Asp Val Ile Thr Asp Ile Glu Met Val Asp Glu Gly 
    450                 455                 460                 


Trp Trp Arg Gly Arg Cys His Gly His Phe Gly Leu Phe Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Lys Leu Leu Glu 
                485     


<210>  123
<211>  923
<212>  PRT
<213>  Homo sapiens;

<400>  123

Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu 
1               5                   10                  15      


Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu 
            20                  25                  30          


Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln 
        35                  40                  45              


Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly 
    50                  55                  60                  


Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly 
65                  70                  75                  80  


Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu 
                85                  90                  95      


Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly 
            100                 105                 110         


Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro 
        115                 120                 125             


Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala 
    130                 135                 140                 


His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly 
145                 150                 155                 160 


Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu 
                165                 170                 175     


Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly 
            180                 185                 190         


Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg 
        195                 200                 205             


Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val 
    210                 215                 220                 


Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly 
225                 230                 235                 240 


Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg 
                245                 250                 255     


His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val 
            260                 265                 270         


Glu Trp Gly Ser Phe Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr 
        275                 280                 285             


Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln 
    290                 295                 300                 


Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg 
305                 310                 315                 320 


Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys 
                325                 330                 335     


Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val 
            340                 345                 350         


Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile 
        355                 360                 365             


Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val 
    370                 375                 380                 


Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala 
385                 390                 395                 400 


Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln 
                405                 410                 415     


Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg 
            420                 425                 430         


His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala 
        435                 440                 445             


Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg 
    450                 455                 460                 


Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln 
                485                 490                 495     


Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu 
            500                 505                 510         


Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala 
        515                 520                 525             


Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly 
    530                 535                 540                 


Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln 
545                 550                 555                 560 


Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser 
                565                 570                 575     


Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln 
            580                 585                 590         


Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val 
625                 630                 635                 640 


Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn 
                645                 650                 655     


Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly 
            660                 665                 670         


Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly 
    690                 695                 700                 


Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp 
                725                 730                 735     


Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr 
        755                 760                 765             


Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr 
    770                 775                 780                 


Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser 
785                 790                 795                 800 


Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro 
                805                 810                 815     


Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val 
            820                 825                 830         


Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val 
        835                 840                 845             


Glu Lys Ile Arg Glu Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu 
865                 870                 875                 880 


Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe 
                885                 890                 895     


Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala 
            900                 905                 910         


Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val 
        915                 920             


<210>  124
<211>  632
<212>  PRT
<213>  Homo sapiens;

<400>  124

Met Asn Arg Tyr Thr Thr Ile Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
1               5                   10                  15      


Ser Val Leu Leu Gly Arg Ser Ile Glu Ser Gly Glu Leu Ile Ala Ile 
            20                  25                  30          


Lys Lys Met Lys Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 
        35                  40                  45              


Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys 
    50                  55                  60                  


Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
65                  70                  75                  80  


Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn Lys Leu 
                85                  90                  95      


Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Leu Lys Pro 
        115                 120                 125             


Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Ile Arg Ser Lys Pro Pro Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 
                165                 170                 175     


Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 
            180                 185                 190         


Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr 
        195                 200                 205             


Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr Asp Trp 
    210                 215                 220                 


Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe Arg Trp Pro Gln 
225                 230                 235                 240 


Cys Val Pro Asn Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Ser Glu 
                245                 250                 255     


Ala Val Gln Leu Leu Arg Asp Met Leu Gln Trp Asp Pro Lys Lys Arg 
            260                 265                 270         


Pro Thr Ala Ser Gln Ala Leu Arg Tyr Pro Tyr Phe Gln Val Gly His 
        275                 280                 285             


Pro Leu Gly Ser Thr Thr Gln Asn Leu Gln Asp Ser Glu Lys Pro Gln 
    290                 295                 300                 


Lys Gly Ile Leu Glu Lys Ala Gly Pro Pro Pro Tyr Ile Lys Pro Val 
305                 310                 315                 320 


Pro Pro Ala Gln Pro Pro Ala Lys Pro His Thr Arg Ile Ser Ser Arg 
                325                 330                 335     


Gln His Gln Ala Ser Gln Pro Pro Leu His Leu Thr Tyr Pro Tyr Lys 
            340                 345                 350         


Ala Glu Val Ser Arg Thr Asp His Pro Ser His Leu Gln Glu Asp Lys 
        355                 360                 365             


Pro Ser Pro Leu Leu Phe Pro Ser Leu His Asn Lys His Pro Gln Ser 
    370                 375                 380                 


Lys Ile Thr Ala Gly Leu Glu His Lys Asn Gly Glu Ile Lys Pro Lys 
385                 390                 395                 400 


Ser Arg Arg Arg Trp Gly Leu Ile Ser Arg Ser Thr Lys Asp Ser Asp 
                405                 410                 415     


Asp Trp Ala Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg 
            420                 425                 430         


Ile Asp Leu Lys Asn Lys Lys Arg Gln Ser Asp Asp Thr Leu Cys Arg 
        435                 440                 445             


Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly 
    450                 455                 460                 


Asn Ser Ala Pro Thr Gln Thr Ser Tyr Gln Arg Arg Asp Thr Pro Thr 
465                 470                 475                 480 


Leu Arg Ser Ala Ala Lys Gln His Tyr Leu Lys His Ser Arg Tyr Leu 
                485                 490                 495     


Pro Gly Ile Ser Ile Arg Asn Gly Ile Leu Ser Asn Pro Gly Lys Glu 
            500                 505                 510         


Phe Ile Pro Pro Asn Pro Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser 
        515                 520                 525             


Ser Gly Thr Met Ser Val Ile Ser Lys Val Asn Ser Val Gly Ser Ser 
    530                 535                 540                 


Ser Thr Ser Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 
545                 550                 555                 560 


Lys Lys Glu Ile Gly Ser Ala Met Gln Arg Val His Leu Ala Pro Ile 
                565                 570                 575     


Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg Pro His 
            580                 585                 590         


Pro Gly Arg Pro Phe Phe His Thr Gln Pro Arg Ser Thr Pro Gly Leu 
        595                 600                 605             


Ile Pro Arg Pro Pro Ala Ala Gln Pro Val His Gly Arg Thr Asp Trp 
    610                 615                 620                 


Ala Ser Lys Tyr Ala Ser Arg Arg 
625                 630         


<210>  125
<211>  282
<212>  PRT
<213>  Homo sapiens;

<400>  125

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210>  126
<211>  557
<212>  PRT
<213>  Homo sapiens;

<400>  126

Met Pro Glu Arg Asp Ser Glu Pro Phe Ser Asn Pro Leu Ala Pro Asp 
1               5                   10                  15      


Gly His Asp Val Asp Asp Pro His Ser Phe His Gln Ser Lys Leu Thr 
            20                  25                  30          


Asn Glu Asp Phe Arg Lys Leu Leu Met Thr Pro Arg Ala Ala Pro Thr 
        35                  40                  45              


Ser Ala Pro Pro Ser Lys Ser Arg His His Glu Met Pro Arg Glu Tyr 
    50                  55                  60                  


Asn Glu Asp Glu Asp Pro Ala Ala Arg Arg Arg Lys Lys Lys Ser Tyr 
65                  70                  75                  80  


Tyr Ala Lys Leu Arg Gln Gln Glu Ile Glu Arg Glu Arg Glu Leu Ala 
                85                  90                  95      


Glu Lys Tyr Arg Asp Arg Ala Lys Glu Arg Arg Asp Gly Val Asn Lys 
            100                 105                 110         


Asp Tyr Glu Glu Thr Glu Leu Ile Ser Thr Thr Ala Asn Tyr Arg Ala 
        115                 120                 125             


Val Gly Pro Thr Ala Glu Ala Asp Lys Ser Ala Ala Glu Lys Arg Arg 
    130                 135                 140                 


Gln Leu Ile Gln Glu Ser Lys Phe Leu Gly Gly Asp Met Glu His Thr 
145                 150                 155                 160 


His Leu Val Lys Gly Leu Asp Phe Ala Leu Leu Gln Lys Val Arg Ala 
                165                 170                 175     


Glu Ile Ala Ser Lys Glu Lys Glu Glu Glu Glu Leu Met Glu Lys Pro 
            180                 185                 190         


Gln Lys Glu Thr Lys Lys Asp Glu Asp Pro Glu Asn Lys Ile Glu Phe 
        195                 200                 205             


Lys Thr Arg Leu Gly Arg Asn Val Tyr Arg Met Leu Phe Lys Ser Lys 
    210                 215                 220                 


Ala Tyr Glu Arg Asn Glu Leu Phe Leu Pro Gly Arg Met Ala Tyr Val 
225                 230                 235                 240 


Val Asp Leu Asp Asp Glu Tyr Ala Asp Thr Asp Ile Pro Thr Thr Leu 
                245                 250                 255     


Ile Arg Ser Lys Ala Asp Cys Pro Thr Met Glu Ala Gln Thr Thr Leu 
            260                 265                 270         


Thr Thr Asn Asp Ile Val Ile Ser Lys Leu Thr Gln Ile Leu Ser Tyr 
        275                 280                 285             


Leu Arg Gln Gly Thr Arg Asn Lys Lys Leu Lys Lys Lys Asp Lys Gly 
    290                 295                 300                 


Lys Leu Glu Glu Lys Lys Pro Pro Glu Ala Asp Met Asn Ile Phe Glu 
305                 310                 315                 320 


Asp Ile Gly Asp Tyr Val Pro Ser Thr Thr Lys Thr Pro Arg Asp Lys 
                325                 330                 335     


Glu Arg Glu Arg Tyr Arg Glu Arg Glu Arg Asp Arg Glu Arg Asp Arg 
            340                 345                 350         


Asp Arg Asp Arg Glu Arg Glu Arg Glu Arg Asp Arg Glu Arg Glu Arg 
        355                 360                 365             


Glu Arg Asp Arg Glu Arg Glu Glu Glu Lys Lys Arg His Ser Tyr Phe 
    370                 375                 380                 


Glu Lys Pro Lys Val Asp Asp Glu Pro Met Asp Val Asp Lys Gly Pro 
385                 390                 395                 400 


Gly Ser Thr Lys Glu Leu Ile Lys Ser Ile Asn Glu Lys Phe Ala Gly 
                405                 410                 415     


Ser Ala Gly Trp Glu Gly Thr Glu Ser Leu Lys Lys Pro Glu Asp Lys 
            420                 425                 430         


Lys Gln Leu Gly Asp Phe Phe Gly Met Ser Asn Ser Tyr Ala Glu Cys 
        435                 440                 445             


Tyr Pro Ala Thr Met Asp Asp Met Ala Val Asp Ser Asp Glu Glu Val 
    450                 455                 460                 


Asp Tyr Ser Lys Met Asp Gln Gly Asn Lys Lys Gly Pro Leu Gly Arg 
465                 470                 475                 480 


Trp Asp Phe Asp Thr Gln Glu Glu Tyr Ser Glu Tyr Met Asn Asn Lys 
                485                 490                 495     


Glu Ala Leu Pro Lys Ala Ala Phe Gln Tyr Gly Ile Lys Met Ser Glu 
            500                 505                 510         


Gly Arg Lys Thr Arg Arg Phe Lys Glu Thr Asn Asp Lys Ala Glu Leu 
        515                 520                 525             


Asp Arg Gln Trp Lys Lys Ile Ser Ala Ile Ile Glu Lys Arg Lys Lys 
    530                 535                 540                 


Met Glu Ala Asp Gly Val Glu Val Lys Arg Pro Lys Tyr 
545                 550                 555         


<210>  127
<211>  419
<212>  PRT
<213>  Homo sapiens;

<400>  127

Met Gly Glu Lys Lys Pro Glu Pro Leu Asp Phe Val Lys Asp Phe Gln 
1               5                   10                  15      


Glu Tyr Leu Thr Gln Gln Thr His His Val Asn Met Ile Ser Gly Ser 
            20                  25                  30          


Val Ser Gly Asp Lys Glu Ala Glu Ala Leu Gln Gly Ala Gly Thr Asp 
        35                  40                  45              


Gly Asp Gln Asn Gly Leu Asp His Pro Ser Val Glu Val Ser Leu Asp 
    50                  55                  60                  


Glu Asn Ser Gly Met Leu Val Asp Gly Phe Glu Arg Thr Phe Asp Gly 
65                  70                  75                  80  


Lys Leu Lys Cys Arg Tyr Cys Asn Tyr Ala Ser Lys Gly Thr Ala Arg 
                85                  90                  95      


Leu Ile Glu His Ile Arg Ile His Thr Gly Glu Lys Pro His Arg Cys 
            100                 105                 110         


His Leu Cys Pro Phe Ala Ser Ala Tyr Glu Arg His Leu Glu Ala His 
        115                 120                 125             


Met Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Ser 
    130                 135                 140                 


Phe Arg Cys Ser Asp Arg Ser Asn Leu Ser His His Arg Arg Arg Lys 
145                 150                 155                 160 


His Lys Met Val Pro Ile Lys Gly Thr Arg Ser Ser Leu Ser Ser Lys 
                165                 170                 175     


Lys Met Trp Gly Val Leu Gln Lys Lys Thr Ser Asn Leu Gly Tyr Ser 
            180                 185                 190         


Arg Arg Ala Leu Ile Asn Leu Ser Pro Pro Ser Met Val Val Gln Lys 
        195                 200                 205             


Pro Asp Tyr Leu Asn Asp Phe Thr His Glu Ile Pro Asn Ile Gln Thr 
    210                 215                 220                 


Asp Ser Tyr Glu Ser Met Ala Lys Thr Thr Pro Thr Gly Gly Leu Pro 
225                 230                 235                 240 


Arg Asp Pro Gln Glu Leu Met Val Asp Asn Pro Leu Asn Gln Leu Ser 
                245                 250                 255     


Thr Leu Ala Gly Gln Leu Ser Ser Leu Pro Pro Glu Asn Gln Asn Pro 
            260                 265                 270         


Ala Ser Pro Asp Val Val Pro Cys Pro Asp Glu Lys Pro Phe Met Ile 
        275                 280                 285             


Gln Gln Pro Ser Thr Gln Ala Val Val Ser Ala Val Ser Ala Ser Ile 
    290                 295                 300                 


Pro Gln Ser Ser Ser Pro Thr Ser Pro Glu Pro Arg Pro Ser His Ser 
305                 310                 315                 320 


Gln Arg Asn Tyr Ser Pro Val Ala Gly Pro Ser Ser Glu Pro Ser Ala 
                325                 330                 335     


His Thr Ser Thr Pro Ser Ile Gly Asn Ser Gln Pro Ser Thr Pro Ala 
            340                 345                 350         


Pro Ala Leu Pro Val Gln Asp Pro Gln Leu Leu His His Cys Gln His 
        355                 360                 365             


Cys Asp Met Tyr Phe Ala Asp Asn Ile Leu Tyr Thr Ile His Met Gly 
    370                 375                 380                 


Cys His Gly Tyr Glu Asn Pro Phe Gln Cys Asn Ile Cys Gly Cys Lys 
385                 390                 395                 400 


Cys Lys Asn Lys Tyr Asp Phe Ala Cys His Phe Ala Arg Gly Gln His 
                405                 410                 415     


Asn Gln His 
            


<210>  128
<211>  551
<212>  PRT
<213>  Homo sapiens;

<400>  128

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  129
<211>  599
<212>  PRT
<213>  Homo sapiens;

<400>  129

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Pro Arg Leu Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 
    50                  55                  60                  


Leu Ser Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 
                85                  90                  95      


Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala 
            100                 105                 110         


Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp 
        115                 120                 125             


Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile 
    130                 135                 140                 


Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu 
145                 150                 155                 160 


Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile 
                165                 170                 175     


His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 
            180                 185                 190         


Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 
        195                 200                 205             


Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 
    210                 215                 220                 


Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val 
225                 230                 235                 240 


Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His 
                245                 250                 255     


Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val 
            260                 265                 270         


Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg 
        275                 280                 285             


Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val 
    290                 295                 300                 


Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 
305                 310                 315                 320 


Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 
                325                 330                 335     


Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly 
            340                 345                 350         


Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln 
        355                 360                 365             


Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val 
    370                 375                 380                 


Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp 
385                 390                 395                 400 


Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys 
                405                 410                 415     


Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 
            420                 425                 430         


Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 
        435                 440                 445             


Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 
    450                 455                 460                 


Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu 
465                 470                 475                 480 


Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr 
                485                 490                 495     


Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln 
            500                 505                 510         


Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val 
        515                 520                 525             


Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr 
    530                 535                 540                 


Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 
545                 550                 555                 560 


Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 
                565                 570                 575     


Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 
            580                 585                 590         


Ser Tyr Glu Lys Arg Leu Tyr 
        595                 


<210>  130
<211>  1188
<212>  PRT
<213>  Homo sapiens;

<400>  130

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro Arg 
        115                 120                 125             


Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro Phe 
    130                 135                 140                 


Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu Ser 
145                 150                 155                 160 


Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu Pro 
                165                 170                 175     


Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu Ala 
            180                 185                 190         


Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His Leu 
        195                 200                 205             


Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val Ile 
    210                 215                 220                 


Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln Gln 
225                 230                 235                 240 


Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala Asn 
                245                 250                 255     


Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu Ser 
            260                 265                 270         


Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu Ser 
        275                 280                 285             


Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys Ala 
    290                 295                 300                 


Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val Glu 
305                 310                 315                 320 


Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp Lys 
                325                 330                 335     


Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys Phe 
            340                 345                 350         


Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile Leu 
        355                 360                 365             


Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe Cys 
    370                 375                 380                 


Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro 
385                 390                 395                 400 


Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala Pro 
                405                 410                 415     


Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly Lys 
            420                 425                 430         


Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val Ile 
        435                 440                 445             


Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile Leu 
    450                 455                 460                 


Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val Ala 
465                 470                 475                 480 


Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro Glu 
                485                 490                 495     


His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr Gly 
            500                 505                 510         


Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe Met 
        515                 520                 525             


Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser Gly 
    530                 535                 540                 


Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu Arg 
545                 550                 555                 560 


Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr His 
                565                 570                 575     


Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val Asp 
            580                 585                 590         


Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln Gln 
        595                 600                 605             


Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg Arg 
    610                 615                 620                 


Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe Ala 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr Thr 
                645                 650                 655     


Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys Asp 
            660                 665                 670         


Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln Ser 
        675                 680                 685             


Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val Phe 
    690                 695                 700                 


Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn Gly 
705                 710                 715                 720 


Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys Tyr 
                725                 730                 735     


Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe His 
            740                 745                 750         


Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn Glu 
        755                 760                 765             


Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu Pro 
    770                 775                 780                 


Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln His 
785                 790                 795                 800 


Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly Glu 
                805                 810                 815     


Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro Ile 
            820                 825                 830         


Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln Gly 
        835                 840                 845             


Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu Tyr 
    850                 855                 860                 


Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr Leu 
865                 870                 875                 880 


Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr Ser 
                885                 890                 895     


Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn Pro 
            900                 905                 910         


Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His Val 
        915                 920                 925             


Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr Asp 
    930                 935                 940                 


Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser Pro 
945                 950                 955                 960 


Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu Pro 
                965                 970                 975     


Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg Pro 
            980                 985                 990         


Ser Asp Leu Gly Lys Asn Ala Gly  Asp Thr Leu Pro Gln  Glu Asp Leu 
        995                 1000                 1005             


Pro Leu  Thr Lys Pro Glu Met  Phe Glu Asn Pro Leu  Tyr Gly Ser 
    1010                 1015                 1020             


Leu Ser  Ser Phe Pro Lys Pro  Ala Pro Arg Lys Asp  Gln Glu Ser 
    1025                 1030                 1035             


Pro Lys  Met Pro Arg Lys Glu  Pro Pro Pro Cys Pro  Glu Pro Gly 
    1040                 1045                 1050             


Ile Leu  Ser Pro Ser Ile Val  Leu Thr Lys Ala Gln  Glu Ala Asp 
    1055                 1060                 1065             


Arg Gly  Glu Gly Pro Gly Lys  Gln Val Pro Ala Pro  Arg Leu Arg 
    1070                 1075                 1080             


Ser Phe  Thr Cys Ser Ser Ser  Ala Glu Gly Arg Ala  Ala Gly Gly 
    1085                 1090                 1095             


Asp Lys  Ser Gln Gly Lys Pro  Lys Thr Pro Val Ser  Ser Gln Ala 
    1100                 1105                 1110             


Pro Val  Pro Ala Lys Arg Pro  Ile Lys Pro Ser Arg  Ser Glu Ile 
    1115                 1120                 1125             


Asn Gln  Gln Thr Pro Pro Thr  Pro Thr Pro Arg Pro  Pro Leu Pro 
    1130                 1135                 1140             


Val Lys  Ser Pro Ala Val Leu  His Leu Gln His Ser  Lys Gly Arg 
    1145                 1150                 1155             


Asp Tyr  Arg Asp Asn Thr Glu  Leu Pro His His Gly  Lys His Arg 
    1160                 1165                 1170             


Pro Glu  Glu Gly Pro Pro Gly  Pro Leu Gly Arg Thr  Ala Met Gln 
    1175                 1180                 1185             


<210>  131
<211>  1137
<212>  PRT
<213>  Homo sapiens;

<400>  131

Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys 
1               5                   10                  15      


Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val 
            20                  25                  30          


Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Phe Ser Val Ala Leu His Arg Gln Leu Gln Pro 
    50                  55                  60                  


Arg Pro Gln Ser Trp Leu Leu Val Gly Ala Pro Gln Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Gly Gln Gln Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu 
                85                  90                  95      


Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Ala 
            100                 105                 110         


Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val 
        115                 120                 125             


Arg Ser Gln Gly Pro Gly Gly Lys Ile Val Thr Cys Ala His Arg Tyr 
    130                 135                 140                 


Glu Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile 
145                 150                 155                 160 


Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu 
                165                 170                 175     


Asp Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu 
            180                 185                 190         


Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp 
        195                 200                 205             


Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly 
    210                 215                 220                 


Leu Leu Phe Val Thr Asn Ile Asp Ser Ser Asp Pro Asp Gln Leu Val 
225                 230                 235                 240 


Tyr Lys Thr Leu Asp Pro Ala Asp Arg Leu Pro Gly Pro Ala Gly Asp 
                245                 250                 255     


Leu Ala Leu Asn Ser Tyr Leu Gly Phe Ser Ile Asp Ser Gly Lys Gly 
            260                 265                 270         


Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly Ala Pro Arg Ala 
        275                 280                 285             


Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp Ser Ala Ser Arg 
    290                 295                 300                 


Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu Thr Ser Gly Phe 
305                 310                 315                 320 


Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp Gly Trp Pro Asp 
                325                 330                 335     


Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln Glu Glu Leu Gly 
            340                 345                 350         


Gly Ala Val Tyr Val Tyr Leu Asn Gln Gly Gly His Trp Ala Gly Ile 
        355                 360                 365             


Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Ser Met Phe Gly Ile Ser 
    370                 375                 380                 


Leu Ala Val Leu Gly Asp Leu Asn Gln Asp Gly Phe Pro Asp Ile Ala 
385                 390                 395                 400 


Val Gly Ala Pro Phe Asp Gly Asp Gly Lys Val Phe Ile Tyr His Gly 
                405                 410                 415     


Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val Leu Glu Gly Glu 
            420                 425                 430         


Ala Val Gly Ile Lys Ser Phe Gly Tyr Ser Leu Ser Gly Ser Leu Asp 
        435                 440                 445             


Met Asp Gly Asn Gln Tyr Pro Asp Leu Leu Val Gly Ser Leu Ala Asp 
    450                 455                 460                 


Thr Ala Val Leu Phe Arg Ala Arg Pro Ile Leu His Val Ser His Glu 
465                 470                 475                 480 


Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln Pro Asn Cys Ala 
                485                 490                 495     


Gly Gly His Ser Val Cys Val Asp Leu Arg Val Cys Phe Ser Tyr Ile 
            500                 505                 510         


Ala Val Pro Ser Ser Tyr Ser Pro Thr Val Ala Leu Asp Tyr Val Leu 
        515                 520                 525             


Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val Pro Arg Val Thr 
    530                 535                 540                 


Phe Leu Ser Arg Asn Leu Glu Glu Pro Lys His Gln Ala Ser Gly Thr 
545                 550                 555                 560 


Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly Asp Ala Met Phe 
                565                 570                 575     


Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala Ile Val Val Thr 
            580                 585                 590         


Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu Arg Arg Gln Ala Pro Gly 
        595                 600                 605             


Gln Gly Leu Pro Pro Val Ala Pro Ile Leu Asn Ala His Gln Pro Ser 
    610                 615                 620                 


Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly Cys Gly Glu Asp 
625                 630                 635                 640 


Lys Ile Cys Gln Ser Asn Leu Gln Leu Val Arg Ala Arg Phe Cys Thr 
                645                 650                 655     


Arg Val Ser Asp Thr Glu Phe Gln Pro Leu Pro Met Asp Val Asp Gly 
            660                 665                 670         


Thr Thr Ala Leu Phe Ala Leu Ser Gly Gln Pro Val Ile Gly Leu Glu 
        675                 680                 685             


Leu Met Val Thr Asn Leu Pro Ser Asp Pro Ala Gln Pro Gln Ala Asp 
    690                 695                 700                 


Gly Asp Asp Ala His Glu Ala Gln Leu Leu Val Met Leu Pro Asp Ser 
705                 710                 715                 720 


Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro Ala Glu Lys Pro Leu 
                725                 730                 735     


Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys Glu Leu Gly Asn 
            740                 745                 750         


Pro Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu Ile Leu Ser Thr 
        755                 760                 765             


Ser Gly Ile Ser Ile Glu Thr Thr Glu Leu Glu Val Glu Leu Leu Leu 
    770                 775                 780                 


Ala Thr Ile Ser Glu Gln Glu Leu His Pro Val Ser Ala Arg Ala Arg 
785                 790                 795                 800 


Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met Ala Ile Pro Gln 
                805                 810                 815     


Gln Leu Phe Phe Ser Gly Val Val Arg Gly Glu Arg Ala Met Gln Ser 
            820                 825                 830         


Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val Thr Val Ser Asn 
        835                 840                 845             


Gln Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala Phe Leu Asn Ile Met 
    850                 855                 860                 


Trp Pro His Glu Ile Ala Asn Gly Lys Trp Leu Leu Tyr Pro Met Gln 
865                 870                 875                 880 


Val Glu Leu Glu Gly Gly Gln Gly Pro Gly Gln Lys Gly Leu Cys Ser 
                885                 890                 895     


Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser Arg Asp Arg Arg 
            900                 905                 910         


Arg Arg Glu Leu Glu Pro Pro Glu Gln Gln Glu Pro Gly Glu Arg Gln 
        915                 920                 925             


Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu Lys Lys Lys 
    930                 935                 940                 


Asn Ile Thr Leu Asp Cys Ala Arg Gly Thr Ala Asn Cys Val Val Phe 
945                 950                 955                 960 


Ser Cys Pro Leu Tyr Ser Phe Asp Arg Ala Ala Val Leu His Val Trp 
                965                 970                 975     


Gly Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser Ala Val Lys 
            980                 985                 990         


Ser Leu Glu Val Ile Val Arg Ala  Asn Ile Thr Val Lys  Ser Ser Ile 
        995                 1000                 1005             


Lys Asn  Leu Met Leu Arg Asp  Ala Ser Thr Val Ile  Pro Val Met 
    1010                 1015                 1020             


Val Tyr  Leu Asp Pro Met Ala  Val Val Ala Glu Gly  Val Pro Trp 
    1025                 1030                 1035             


Trp Val  Ile Leu Leu Ala Val  Leu Ala Gly Leu Leu  Val Leu Ala 
    1040                 1045                 1050             


Leu Leu  Val Leu Leu Leu Trp  Lys Met Gly Phe Phe  Lys Arg Ala 
    1055                 1060                 1065             


Lys His  Pro Glu Ala Thr Val  Pro Gln Tyr His Ala  Val Lys Ile 
    1070                 1075                 1080             


Pro Arg  Glu Asp Arg Gln Gln  Phe Lys Glu Glu Lys  Thr Gly Thr 
    1085                 1090                 1095             


Ile Leu  Arg Asn Asn Trp Gly  Ser Pro Arg Arg Glu  Gly Pro Asp 
    1100                 1105                 1110             


Ala His  Pro Ile Leu Ala Ala  Asp Gly His Pro Glu  Leu Gly Pro 
    1115                 1120                 1125             


Asp Gly  His Pro Gly Pro Gly  Thr Ala 
    1130                 1135         


<210>  132
<211>  1246
<212>  PRT
<213>  Homo sapiens;

<400>  132

Met Ser Lys Glu Arg Pro Lys Arg Asn Ile Ile Gln Lys Lys Tyr Asp 
1               5                   10                  15      


Asp Ser Asp Gly Ile Pro Trp Ser Glu Glu Arg Val Val Arg Lys Val 
            20                  25                  30          


Leu Tyr Leu Ser Leu Lys Glu Phe Lys Asn Ser Gln Lys Arg Gln His 
        35                  40                  45              


Ala Glu Gly Ile Ala Gly Ser Leu Lys Thr Val Asn Gly Leu Leu Gly 
    50                  55                  60                  


Asn Asp Gln Ser Lys Gly Leu Gly Pro Ala Ser Glu Gln Ser Glu Asn 
65                  70                  75                  80  


Glu Lys Asp Asp Ala Ser Gln Val Ser Ser Thr Ser Asn Asp Val Ser 
                85                  90                  95      


Ser Ser Asp Phe Glu Glu Gly Pro Ser Arg Lys Arg Pro Arg Leu Gln 
            100                 105                 110         


Ala Gln Arg Lys Phe Ala Gln Ser Gln Pro Asn Ser Pro Ser Thr Thr 
        115                 120                 125             


Pro Val Lys Ile Val Glu Pro Leu Leu Pro Pro Pro Ala Thr Gln Ile 
    130                 135                 140                 


Ser Asp Leu Ser Lys Arg Lys Pro Lys Thr Glu Asp Phe Leu Thr Phe 
145                 150                 155                 160 


Leu Cys Leu Arg Gly Ser Pro Ala Leu Pro Asn Ser Met Val Tyr Phe 
                165                 170                 175     


Gly Ser Ser Gln Asp Glu Glu Glu Val Glu Glu Glu Asp Asp Glu Thr 
            180                 185                 190         


Glu Asp Val Lys Thr Ala Thr Asn Asn Ala Ser Ser Ser Cys Gln Ser 
        195                 200                 205             


Thr Pro Arg Lys Gly Lys Thr His Lys His Val His Asn Gly His Val 
    210                 215                 220                 


Phe Asn Gly Ser Ser Arg Ser Thr Arg Glu Lys Glu Pro Val Gln Lys 
225                 230                 235                 240 


His Lys Ser Lys Glu Ala Thr Pro Ala Lys Glu Lys His Ser Asp His 
                245                 250                 255     


Arg Ala Asp Ser Arg Arg Glu Gln Ala Ser Ala Asn His Pro Ala Ala 
            260                 265                 270         


Ala Pro Ser Thr Gly Ser Ser Ala Lys Gly Leu Ala Ala Thr His His 
        275                 280                 285             


His Pro Pro Leu His Arg Ser Ala Gln Asp Leu Arg Lys Gln Val Ser 
    290                 295                 300                 


Lys Val Asn Gly Val Thr Arg Met Ser Ser Leu Gly Ala Gly Val Thr 
305                 310                 315                 320 


Ser Ala Lys Lys Met Arg Glu Val Arg Pro Ser Pro Ser Lys Thr Val 
                325                 330                 335     


Lys Tyr Thr Ala Thr Val Thr Lys Gly Ala Val Thr Tyr Thr Lys Ala 
            340                 345                 350         


Lys Arg Glu Leu Val Lys Asp Thr Lys Pro Asn His His Lys Pro Ser 
        355                 360                 365             


Ser Ala Val Asn His Thr Ile Ser Gly Lys Thr Glu Ser Ser Asn Ala 
    370                 375                 380                 


Lys Thr Arg Lys Gln Val Leu Ser Leu Gly Gly Ala Ser Lys Ser Thr 
385                 390                 395                 400 


Gly Pro Ala Val Asn Gly Leu Lys Val Ser Gly Arg Leu Asn Pro Lys 
                405                 410                 415     


Ser Cys Thr Lys Glu Val Gly Gly Arg Gln Leu Arg Glu Gly Leu Gln 
            420                 425                 430         


Leu Arg Glu Gly Leu Arg Asn Ser Lys Arg Arg Leu Glu Glu Ala His 
        435                 440                 445             


Gln Ala Glu Lys Pro Gln Ser Pro Pro Lys Lys Met Lys Gly Ala Ala 
    450                 455                 460                 


Gly Pro Ala Glu Gly Pro Gly Lys Lys Ala Pro Ala Glu Arg Gly Leu 
465                 470                 475                 480 


Leu Asn Gly His Val Lys Lys Glu Val Pro Glu Arg Ser Leu Glu Arg 
                485                 490                 495     


Asn Arg Pro Lys Arg Ala Thr Ala Gly Lys Ser Thr Pro Gly Arg Gln 
            500                 505                 510         


Ala His Gly Lys Ala Asp Ser Ala Ser Cys Glu Asn Arg Ser Thr Ser 
        515                 520                 525             


Gln Pro Glu Ser Val His Lys Pro Gln Asp Ser Gly Lys Ala Glu Lys 
    530                 535                 540                 


Gly Gly Gly Lys Ala Gly Trp Ala Ala Met Asp Glu Ile Pro Val Leu 
545                 550                 555                 560 


Arg Pro Ser Ala Lys Glu Phe His Asp Pro Leu Ile Tyr Ile Glu Ser 
                565                 570                 575     


Val Arg Ala Gln Val Glu Lys Phe Gly Met Cys Arg Val Ile Pro Pro 
            580                 585                 590         


Pro Asp Trp Arg Pro Glu Cys Lys Leu Asn Asp Glu Met Arg Phe Val 
        595                 600                 605             


Thr Gln Ile Gln His Ile His Lys Leu Gly Arg Arg Trp Gly Pro Asn 
    610                 615                 620                 


Val Gln Arg Leu Ala Cys Ile Lys Lys His Leu Lys Ser Gln Gly Ile 
625                 630                 635                 640 


Thr Met Asp Glu Leu Pro Leu Ile Gly Gly Cys Glu Leu Asp Leu Ala 
                645                 650                 655     


Cys Phe Phe Arg Leu Ile Asn Glu Met Gly Gly Met Gln Gln Val Thr 
            660                 665                 670         


Asp Leu Lys Lys Trp Asn Lys Leu Ala Asp Met Leu Arg Ile Pro Arg 
        675                 680                 685             


Thr Ala Gln Asp Arg Leu Ala Lys Leu Gln Glu Ala Tyr Cys Gln Tyr 
    690                 695                 700                 


Leu Leu Ser Tyr Asp Ser Leu Ser Pro Glu Glu His Arg Arg Leu Glu 
705                 710                 715                 720 


Lys Glu Val Leu Met Glu Lys Glu Ile Leu Glu Lys Arg Lys Gly Pro 
                725                 730                 735     


Leu Glu Gly His Thr Glu Asn Asp His His Lys Phe His Pro Leu Pro 
            740                 745                 750         


Arg Phe Glu Pro Lys Asn Gly Leu Ile His Gly Val Ala Pro Arg Asn 
        755                 760                 765             


Gly Phe Arg Ser Lys Leu Lys Glu Val Gly Gln Ala Gln Leu Lys Thr 
    770                 775                 780                 


Gly Arg Arg Arg Leu Phe Ala Gln Glu Lys Glu Val Val Lys Glu Glu 
785                 790                 795                 800 


Glu Glu Asp Lys Gly Val Leu Asn Asp Phe His Lys Cys Ile Tyr Lys 
                805                 810                 815     


Gly Arg Ser Val Ser Leu Thr Thr Phe Tyr Arg Thr Ala Arg Asn Ile 
            820                 825                 830         


Met Ser Met Cys Phe Ser Lys Glu Pro Ala Pro Ala Glu Ile Glu Gln 
        835                 840                 845             


Glu Tyr Trp Arg Leu Val Glu Glu Lys Asp Cys His Val Ala Val His 
    850                 855                 860                 


Cys Gly Lys Val Asp Thr Asn Thr His Gly Ser Gly Phe Pro Val Gly 
865                 870                 875                 880 


Lys Ser Glu Pro Phe Ser Arg His Gly Trp Asn Leu Thr Val Leu Pro 
                885                 890                 895     


Asn Asn Thr Gly Ser Ile Leu Arg His Leu Gly Ala Val Pro Gly Val 
            900                 905                 910         


Thr Ile Pro Trp Leu Asn Ile Gly Met Val Phe Ser Thr Ser Cys Trp 
        915                 920                 925             


Ser Arg Asp Gln Asn His Leu Pro Tyr Ile Asp Tyr Leu His Thr Gly 
    930                 935                 940                 


Ala Asp Cys Ile Trp Tyr Cys Ile Pro Ala Glu Glu Glu Asn Lys Leu 
945                 950                 955                 960 


Glu Asp Val Val His Thr Leu Leu Gln Ala Asn Gly Thr Pro Gly Leu 
                965                 970                 975     


Gln Met Leu Glu Ser Asn Val Met Ile Ser Pro Glu Val Leu Cys Lys 
            980                 985                 990         


Glu Gly Ile Lys Val His Arg Thr  Val Gln Gln Ser Gly  Gln Phe Val 
        995                 1000                 1005             


Val Cys  Phe Pro Gly Ser Phe  Val Ser Lys Val Cys  Cys Gly Tyr 
    1010                 1015                 1020             


Ser Val  Ser Glu Thr Val His  Phe Ala Thr Thr Gln  Trp Thr Ser 
    1025                 1030                 1035             


Met Gly  Phe Glu Thr Ala Lys  Glu Met Lys Arg Arg  His Ile Ala 
    1040                 1045                 1050             


Lys Pro  Phe Ser Met Glu Lys  Leu Leu Tyr Gln Ile  Ala Gln Ala 
    1055                 1060                 1065             


Glu Ala  Lys Lys Glu Asn Gly  Pro Thr Leu Ser Thr  Ile Ser Ala 
    1070                 1075                 1080             


Leu Leu  Asp Glu Leu Arg Asp  Thr Glu Leu Arg Gln  Arg Arg Gln 
    1085                 1090                 1095             


Leu Phe  Glu Ala Gly Leu His  Ser Ser Ala Arg Tyr  Gly Ser His 
    1100                 1105                 1110             


Asp Gly  Ser Ser Thr Val Ala  Asp Gly Lys Lys Lys  Pro Arg Lys 
    1115                 1120                 1125             


Trp Leu  Gln Leu Glu Thr Ser  Glu Arg Arg Cys Gln  Ile Cys Gln 
    1130                 1135                 1140             


His Leu  Cys Tyr Leu Ser Met  Val Val Gln Glu Asn  Glu Asn Val 
    1145                 1150                 1155             


Val Phe  Cys Leu Glu Cys Ala  Leu Arg His Val Glu  Lys Gln Lys 
    1160                 1165                 1170             


Ser Cys  Arg Gly Leu Lys Leu  Met Tyr Arg Tyr Asp  Glu Glu Gln 
    1175                 1180                 1185             


Ile Ile  Ser Leu Val Asn Gln  Ile Cys Gly Lys Val  Ser Gly Lys 
    1190                 1195                 1200             


Asn Gly  Ser Ile Glu Asn Cys  Leu Ser Lys Pro Thr  Pro Lys Arg 
    1205                 1210                 1215             


Gly Pro  Arg Lys Arg Ala Thr  Val Asp Val Pro Pro  Ser Arg Leu 
    1220                 1225                 1230             


Ser Ala  Ser Ser Ser Ser Lys  Ser Ala Ser Ser Ser  Ser 
    1235                 1240                 1245     


<210>  133
<211>  111
<212>  PRT
<213>  Homo sapiens;

<400>  133

Met Val Arg Thr Lys Ala Asp Ser Val Pro Gly Thr Tyr Arg Lys Val 
1               5                   10                  15      


Val Ala Ala Arg Ala Pro Arg Lys Val Leu Gly Ser Ser Thr Ser Ala 
            20                  25                  30          


Thr Asn Ser Thr Ser Val Ser Ser Arg Lys Ala Glu Asn Lys Tyr Ala 
        35                  40                  45              


Gly Gly Asn Pro Val Cys Val Arg Pro Thr Pro Lys Trp Gln Lys Gly 
    50                  55                  60                  


Ile Gly Glu Phe Phe Arg Leu Ser Pro Lys Asp Ser Glu Lys Glu Asn 
65                  70                  75                  80  


Gln Ile Pro Glu Glu Ala Gly Ser Ser Gly Leu Gly Lys Ala Lys Arg 
                85                  90                  95      


Lys Ala Cys Pro Leu Gln Pro Asp His Thr Asn Asp Glu Lys Glu 
            100                 105                 110     


<210>  134
<211>  1070
<212>  PRT
<213>  Homo sapiens;

<400>  134

Met Tyr Cys Cys Ser Ala Gln Asp Ser Lys Met Asp Tyr Lys Arg Arg 
1               5                   10                  15      


Phe Leu Leu Gly Gly Ser Lys Gln Lys Val Gln Gln His Gln Gln Tyr 
            20                  25                  30          


Pro Met Pro Glu Leu Gly Arg Ala Leu Ser Ala Pro Leu Ala Ser Thr 
        35                  40                  45              


Ala Thr Thr Ala Pro Leu Gly Ser Leu Thr Ala Ala Gly Ser Cys His 
    50                  55                  60                  


His Ala Met Pro His Thr Thr Pro Ile Ala Asp Ile Gln Gln Gly Ile 
65                  70                  75                  80  


Ser Lys Tyr Leu Asp Ala Leu Asn Val Phe Cys Arg Ala Ser Thr Phe 
                85                  90                  95      


Leu Thr Asp Leu Phe Ser Thr Val Phe Arg Asn Ser His Tyr Ser Lys 
            100                 105                 110         


Ala Ala Thr Gln Leu Lys Asp Val Gln Glu His Val Met Glu Ala Ala 
        115                 120                 125             


Ser Arg Leu Thr Ser Ala Ile Lys Pro Glu Ile Ala Lys Met Leu Met 
    130                 135                 140                 


Glu Leu Ser Ala Gly Ala Ala Asn Phe Thr Asp Gln Lys Glu Phe Ser 
145                 150                 155                 160 


Leu Gln Asp Ile Glu Val Leu Gly Arg Cys Phe Leu Thr Val Val Gln 
                165                 170                 175     


Val His Phe Gln Phe Leu Thr His Ala Leu Gln Lys Val Gln Pro Val 
            180                 185                 190         


Ala His Ser Cys Phe Ala Glu Val Ile Val Pro Glu Lys Lys Asn Ser 
        195                 200                 205             


Gly Ser Gly Gly Gly Leu Ser Gly Met Gly His Thr Pro Glu Val Glu 
    210                 215                 220                 


Glu Ala Val Arg Ser Trp Arg Gly Ala Ala Glu Ala Thr Ser Arg Leu 
225                 230                 235                 240 


Arg Glu Arg Gly Cys Asp Gly Cys Leu Ala Gly Ile Glu Val Gln Gln 
                245                 250                 255     


Leu Phe Cys Ser Gln Ser Ala Ala Ile Pro Glu His Gln Leu Lys Glu 
            260                 265                 270         


Leu Asn Ile Lys Ile Asp Ser Ala Leu Gln Ala Tyr Lys Ile Ala Leu 
        275                 280                 285             


Glu Ser Leu Gly His Cys Glu Tyr Ala Met Lys Ala Gly Phe His Leu 
    290                 295                 300                 


Asn Pro Lys Ala Ile Glu Ala Ser Leu Gln Gly Cys Cys Ser Glu Ala 
305                 310                 315                 320 


Glu Ala Gln Gln Thr Gly Arg Arg Gln Thr Pro Pro Gln Pro Met Gln 
                325                 330                 335     


Cys Glu Leu Pro Thr Val Pro Val Gln Ile Gly Ser His Phe Leu Lys 
            340                 345                 350         


Gly Val Ser Phe Asn Glu Ser Ala Ala Asp Asn Leu Lys Leu Lys Thr 
        355                 360                 365             


His Thr Met Leu Gln Leu Met Lys Glu Ala Gly Cys Tyr Asn Gly Ile 
    370                 375                 380                 


Thr Ser Arg Asp Asp Phe Pro Val Thr Glu Val Leu Asn Gln Val Cys 
385                 390                 395                 400 


Pro Ser Thr Trp Arg Gly Ala Cys Lys Thr Ala Val Gln Leu Leu Phe 
                405                 410                 415     


Gly Gln Ala Gly Leu Val Val Val Asp Thr Ala Gln Ile Glu Asn Lys 
            420                 425                 430         


Glu Ala Tyr Ala Pro Gln Ile Ser Leu Glu Gly Ser Arg Ile Val Val 
        435                 440                 445             


Gln Val Pro Ser Thr Trp Cys Leu Lys Glu Asp Pro Ala Thr Met Ser 
    450                 455                 460                 


Leu Leu Gln Arg Ser Leu Asp Pro Glu Lys Thr Leu Gly Leu Val Asp 
465                 470                 475                 480 


Val Leu Tyr Thr Ala Val Leu Asp Leu Asn Arg Trp Arg Ala Gly Arg 
                485                 490                 495     


Glu Gln Ala Leu Pro Cys Ile Gln Ile Gln Leu Gln Arg Glu Ile Cys 
            500                 505                 510         


Asp Phe Gly Asn Gln Ala Asp Leu Pro Ser Gly Asn Gly Asn Lys Ser 
        515                 520                 525             


Ser Gly Gly Leu Gln Lys Thr Phe Ser Lys Leu Thr Ser Arg Phe Thr 
    530                 535                 540                 


Lys Lys Ala Ser Cys Thr Ser Ser Ser Ser Ser Thr Asn Tyr Ser Ile 
545                 550                 555                 560 


Gln Asn Thr Pro Ser Lys Asn Ile Phe Ile Ala Gly Cys Ser Glu Glu 
                565                 570                 575     


Lys Ala Lys Met Pro Gly Asn Ile Asp Thr Arg Leu Gln Ser Ile Leu 
            580                 585                 590         


Asn Ile Gly Asn Phe Pro Arg Thr Thr Asp Pro Ser Gln Ser Ala Gln 
        595                 600                 605             


Asn Ser Ser Asn Thr Val Ala Asn Gly Phe Leu Met Glu Arg Arg Glu 
    610                 615                 620                 


Asn Phe Leu His Gly Asp Asp Gly Lys Asp Glu Lys Gly Met Asn Leu 
625                 630                 635                 640 


Pro Thr Asp Gln Glu Met Gln Glu Val Ile Asp Phe Leu Ser Gly Phe 
                645                 650                 655     


Asn Met Gly Gln Ser His Gln Gly Ser Pro Leu Val Thr Arg His Asn 
            660                 665                 670         


Ser Ala Ala Thr Ala Met Val Thr Glu Gln Lys Ala Gly Ala Met Gln 
        675                 680                 685             


Pro Gln Gln Pro Ser Leu Pro Val Pro Pro Pro Pro Arg Ala Pro Gln 
    690                 695                 700                 


Ala Gly Ala His Thr Pro Leu Thr Pro Gln Pro Gly Leu Ala Pro Gln 
705                 710                 715                 720 


Gln Gln Ser Pro Lys Gln Gln Gln Pro Gln Val Gln Tyr Tyr Gln His 
                725                 730                 735     


Leu Leu Gln Pro Ile Gly Pro Gln Gln Pro Pro Pro Gln Pro Arg Ala 
            740                 745                 750         


Pro Gly Lys Trp Val His Gly Ser Ser Gln Gln Pro Ala Gln Ala Val 
        755                 760                 765             


Gly Ala Gly Leu Ser Pro Leu Gly Gln Trp Pro Gly Ile Ser Asp Leu 
    770                 775                 780                 


Ser Ser Asp Leu Tyr Ser Leu Gly Leu Val Ser Ser Tyr Met Asp Asn 
785                 790                 795                 800 


Val Met Ser Glu Val Leu Gly Gln Lys Pro Gln Gly Pro Arg Asn Asn 
                805                 810                 815     


Thr Trp Pro Asn Arg Asp Gln Ser Asp Gly Val Phe Gly Met Leu Gly 
            820                 825                 830         


Glu Ile Leu Pro Phe Asp Pro Ala Val Gly Ser Asp Pro Glu Phe Ala 
        835                 840                 845             


Arg Tyr Val Ala Gly Val Ser Gln Ala Met Gln Gln Lys Arg Gln Ala 
    850                 855                 860                 


Gln His Gly Arg Arg Pro Gly Asn Pro Arg Gly Asn Trp Pro Pro Met 
865                 870                 875                 880 


Asp Asp Ala His Arg Thr Trp Pro Phe Pro Glu Phe Phe Thr Glu Gly 
                885                 890                 895     


Asp Gly Leu His Gly Gly Trp Ser Gly Ala Gln Gly Asp Ser Ala Ser 
            900                 905                 910         


Ser Ser Asp Glu Thr Ser Ser Ala Asn Gly Asp Ser Leu Phe Ser Met 
        915                 920                 925             


Phe Ser Gly Pro Asp Leu Val Ala Ala Val Lys Gln Arg Arg Lys His 
    930                 935                 940                 


Ser Ser Gly Glu Gln Asp Thr Ser Thr Leu Pro Ser Pro Pro Leu Leu 
945                 950                 955                 960 


Thr Thr Val Glu Asp Val Asn Gln Asp Asn Lys Thr Lys Thr Trp Pro 
                965                 970                 975     


Pro Lys Ala Pro Trp Gln His Pro Ser Pro Leu Pro Ser Thr Leu Pro 
            980                 985                 990         


Ser Pro Ser Ala Pro Leu Tyr Ala  Val Thr Ser Pro Gly  Ser Gln Trp 
        995                 1000                 1005             


Asn Asp  Thr Met Gln Met Leu  Gln Ser Pro Val Trp  Ala Ala Thr 
    1010                 1015                 1020             


Asn Asp  Cys Ser Ala Ala Ala  Phe Ser Tyr Val Gln  Thr Pro Pro 
    1025                 1030                 1035             


Gln Pro  Pro Pro Pro Pro Ala  His Lys Ala Ala Pro  Lys Gly Phe 
    1040                 1045                 1050             


Lys Ala  Phe Pro Gly Lys Gly  Glu Arg Arg Pro Ala  Tyr Leu Pro 
    1055                 1060                 1065             


Gln Tyr  
    1070 


<210>  135
<211>  614
<212>  PRT
<213>  Homo sapiens;

<400>  135

Met Ser Ala Gly Ser Ala Thr His Pro Gly Ala Gly Gly Arg Arg Ser 
1               5                   10                  15      


Lys Trp Asp Gln Pro Ala Pro Ala Pro Leu Leu Phe Leu Pro Pro Ala 
            20                  25                  30          


Ala Pro Gly Gly Glu Val Thr Ser Ser Gly Gly Ser Pro Gly Gly Thr 
        35                  40                  45              


Thr Ala Ala Pro Ser Gly Ala Leu Asp Ala Ala Ala Ala Val Ala Ala 
    50                  55                  60                  


Lys Ile Asn Ala Met Leu Met Ala Lys Gly Lys Leu Lys Pro Thr Gln 
65                  70                  75                  80  


Asn Ala Ser Glu Lys Leu Gln Ala Pro Gly Lys Gly Leu Thr Ser Asn 
                85                  90                  95      


Lys Ser Lys Asp Asp Leu Val Val Ala Glu Val Glu Ile Asn Asp Val 
            100                 105                 110         


Pro Leu Thr Cys Arg Asn Leu Leu Thr Arg Gly Gln Thr Gln Asp Glu 
        115                 120                 125             


Ile Ser Arg Leu Ser Gly Ala Ala Val Ser Thr Arg Gly Arg Phe Met 
    130                 135                 140                 


Thr Thr Glu Glu Lys Ala Lys Val Gly Pro Gly Asp Arg Pro Leu Tyr 
145                 150                 155                 160 


Leu His Val Gln Gly Gln Thr Arg Glu Leu Val Asp Arg Ala Val Asn 
                165                 170                 175     


Arg Ile Lys Glu Ile Ile Thr Asn Gly Val Val Lys Ala Ala Thr Gly 
            180                 185                 190         


Thr Ser Pro Thr Phe Asn Gly Ala Thr Val Thr Val Tyr His Gln Pro 
        195                 200                 205             


Ala Pro Ile Ala Gln Leu Ser Pro Ala Val Ser Gln Lys Pro Pro Phe 
    210                 215                 220                 


Gln Ser Gly Met His Tyr Val Gln Asp Lys Leu Phe Val Gly Leu Glu 
225                 230                 235                 240 


His Ala Val Pro Thr Phe Asn Val Lys Glu Lys Val Glu Gly Pro Gly 
                245                 250                 255     


Cys Ser Tyr Leu Gln His Ile Gln Ile Glu Thr Gly Ala Lys Val Phe 
            260                 265                 270         


Leu Arg Gly Lys Gly Ser Gly Cys Ile Glu Pro Ala Ser Gly Arg Glu 
        275                 280                 285             


Ala Phe Glu Pro Met Tyr Ile Tyr Ile Ser His Pro Lys Pro Glu Gly 
    290                 295                 300                 


Leu Ala Ala Ala Lys Lys Leu Cys Glu Asn Leu Leu Gln Thr Val His 
305                 310                 315                 320 


Ala Glu Tyr Ser Arg Phe Val Asn Gln Ile Asn Thr Ala Val Pro Leu 
                325                 330                 335     


Pro Gly Tyr Thr Gln Pro Ser Ala Ile Ser Ser Val Pro Pro Gln Pro 
            340                 345                 350         


Pro Tyr Tyr Pro Ser Asn Gly Tyr Gln Ser Gly Tyr Pro Val Val Pro 
        355                 360                 365             


Pro Pro Gln Gln Pro Val Gln Pro Pro Tyr Gly Val Pro Ser Ile Val 
    370                 375                 380                 


Pro Pro Ala Val Ser Leu Ala Pro Gly Val Leu Pro Ala Leu Pro Thr 
385                 390                 395                 400 


Gly Val Pro Pro Val Pro Thr Gln Tyr Pro Ile Thr Gln Val Gln Pro 
                405                 410                 415     


Pro Ala Ser Thr Gly Gln Ser Pro Met Gly Gly Pro Phe Ile Pro Ala 
            420                 425                 430         


Ala Pro Val Lys Thr Ala Leu Pro Ala Gly Pro Gln Pro Gln Pro Gln 
        435                 440                 445             


Pro Gln Pro Pro Leu Pro Ser Gln Pro Gln Ala Gln Lys Arg Arg Phe 
    450                 455                 460                 


Thr Glu Glu Leu Pro Asp Glu Arg Glu Ser Gly Leu Leu Gly Tyr Gln 
465                 470                 475                 480 


His Gly Pro Ile His Met Thr Asn Leu Gly Thr Gly Phe Ser Ser Gln 
                485                 490                 495     


Asn Glu Ile Glu Gly Ala Gly Ser Lys Pro Ala Ser Ser Ser Gly Lys 
            500                 505                 510         


Glu Arg Glu Arg Asp Arg Gln Leu Met Pro Pro Pro Ala Phe Pro Val 
        515                 520                 525             


Thr Gly Ile Lys Thr Glu Ser Asp Glu Arg Asn Gly Ser Gly Thr Leu 
    530                 535                 540                 


Thr Gly Ser His Asp Tyr Pro Ala Lys Lys Met Lys Thr Thr Glu Lys 
545                 550                 555                 560 


Gly Phe Gly Leu Val Ala Tyr Ala Ala Asp Ser Ser Asp Glu Glu Glu 
                565                 570                 575     


Glu His Gly Gly His Lys Asn Ala Ser Ser Phe Pro Gln Gly Trp Ser 
            580                 585                 590         


Leu Gly Tyr Gln Tyr Pro Ser Ser Gln Pro Arg Ala Lys Gln Gln Met 
        595                 600                 605             


Pro Phe Trp Met Ala Pro 
    610                 


<210>  136
<211>  179
<212>  PRT
<213>  Homo sapiens;

<400>  136

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ser Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  137
<211>  231
<212>  PRT
<213>  Homo sapiens;

<400>  137

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln 
    50                  55                  60                  


Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln 
65                  70                  75                  80  


Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn 
                85                  90                  95      


Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val 
            100                 105                 110         


Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe 
        115                 120                 125             


Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu 
    130                 135                 140                 


Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe 
145                 150                 155                 160 


Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn 
                165                 170                 175     


Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile 
            180                 185                 190         


Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys 
        195                 200                 205             


Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
    210                 215                 220                 


Phe Lys Trp Ile Cys Gln Tyr 
225                 230     


<210>  138
<211>  525
<212>  PRT
<213>  Homo sapiens;

<400>  138

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  139
<211>  131
<212>  PRT
<213>  Homo sapiens;

<400>  139

Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 
1               5                   10                  15      


Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 
        35                  40                  45              


Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 
    50                  55                  60                  


Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Ile Glu Trp 
                85                  90                  95      


Gly Ala Cys Ala Leu Val Leu Thr Gly Asn Thr Val Ile Phe Ala Thr 
            100                 105                 110         


Ile Leu Gly Phe Phe Leu Val Phe Gly Ser Asn Asp Asp Phe Ser Trp 
        115                 120                 125             


Gln Gln Trp 
    130     


<210>  140
<211>  896
<212>  PRT
<213>  Homo sapiens;

<400>  140

Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Ile Val Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Lys Gly Ile Asn Gln Ala Thr Leu Ser Gly Cys Ile Asp 
            20                  25                  30          


Val Ile Val Val Gln Gln Gln Asp Gly Ser Tyr Gln Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Lys Glu Lys Val 
    50                  55                  60                  


Ile Asp Ile Glu Ile Asn Gly Ser Ala Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Asn Gly Glu Ala Phe Phe Val Glu Glu Thr Glu Glu Glu Tyr 
                85                  90                  95      


Glu Lys Leu Pro Ala Tyr Leu Ala Thr Ser Pro Ile Pro Thr Glu Asp 
            100                 105                 110         


Gln Phe Phe Lys Asp Ile Asp Thr Pro Leu Val Lys Ser Gly Gly Asp 
        115                 120                 125             


Glu Thr Pro Ser Gln Ser Ser Asp Ile Ser His Val Leu Glu Thr Glu 
    130                 135                 140                 


Thr Ile Phe Thr Pro Ser Ser Val Lys Lys Lys Lys Arg Arg Arg Lys 
145                 150                 155                 160 


Lys Tyr Lys Gln Asp Ser Lys Lys Glu Glu Gln Ala Ala Ser Ala Ala 
                165                 170                 175     


Ala Glu Asp Thr Cys Asp Val Gly Val Ser Ser Asp Asp Asp Lys Gly 
            180                 185                 190         


Ala Gln Ala Ala Arg Gly Ser Ser Asn Ala Ser Leu Lys Glu Glu Glu 
        195                 200                 205             


Cys Lys Glu Pro Leu Leu Phe His Ser Gly Asp His Tyr Pro Leu Ser 
    210                 215                 220                 


Asp Gly Asp Trp Ser Pro Leu Glu Thr Thr Tyr Pro Gln Thr Ala Cys 
225                 230                 235                 240 


Pro Lys Ser Asp Ser Glu Leu Glu Val Lys Pro Ala Glu Ser Leu Leu 
                245                 250                 255     


Arg Ser Glu Ser His Met Glu Trp Thr Trp Gly Gly Phe Pro Glu Ser 
            260                 265                 270         


Thr Lys Val Ser Lys Arg Glu Arg Ser Asp His His Pro Arg Thr Ala 
        275                 280                 285             


Thr Ile Thr Pro Ser Glu Asn Thr His Phe Arg Val Ile Pro Ser Glu 
    290                 295                 300                 


Asp Asn Leu Ile Ser Glu Val Glu Lys Asp Ala Ser Met Glu Asp Thr 
305                 310                 315                 320 


Val Cys Thr Ile Val Lys Pro Lys Pro Arg Ala Leu Gly Thr Gln Met 
                325                 330                 335     


Ser Asp Pro Thr Ser Val Ala Glu Leu Leu Glu Pro Pro Leu Glu Ser 
            340                 345                 350         


Thr Gln Ile Ser Ser Met Leu Asp Ala Asp His Leu Pro Asn Ala Ala 
        355                 360                 365             


Leu Ala Glu Ala Pro Ser Glu Ser Lys Pro Ala Ala Lys Val Asp Ser 
    370                 375                 380                 


Pro Ser Lys Lys Lys Gly Val His Lys Arg Ser Gln His Gln Gly Pro 
385                 390                 395                 400 


Asp Asp Ile Tyr Leu Asp Asp Leu Lys Gly Leu Glu Pro Glu Val Ala 
                405                 410                 415     


Ala Leu Tyr Phe Pro Lys Ser Glu Ser Glu Pro Gly Ser Arg Gln Trp 
            420                 425                 430         


Pro Glu Ser Asp Thr Leu Ser Gly Ser Gln Ser Pro Gln Ser Val Gly 
        435                 440                 445             


Ser Ala Ala Ala Asp Ser Gly Thr Glu Cys Leu Ser Asp Ser Ala Met 
    450                 455                 460                 


Asp Leu Pro Asp Val Thr Leu Ser Leu Cys Gly Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Gly Glu Ile Ser Lys Glu Lys Phe Met Glu His Ile Ile Thr Tyr His 
                485                 490                 495     


Glu Phe Ala Glu Asn Pro Gly Leu Ile Asp Asn Pro Asn Leu Val Ile 
            500                 505                 510         


Arg Ile Tyr Asn Arg Tyr Tyr Asn Trp Ala Leu Ala Ala Pro Met Ile 
        515                 520                 525             


Leu Ser Leu Gln Val Phe Gln Lys Ser Leu Pro Lys Ala Thr Val Glu 
    530                 535                 540                 


Ser Trp Val Lys Asp Lys Met Pro Lys Lys Ser Gly Arg Trp Trp Phe 
545                 550                 555                 560 


Trp Arg Lys Arg Glu Ser Met Thr Lys Gln Leu Pro Glu Ser Lys Glu 
                565                 570                 575     


Gly Lys Ser Glu Ala Pro Pro Ala Ser Asp Leu Pro Ser Ser Ser Lys 
            580                 585                 590         


Glu Pro Ala Gly Ala Arg Pro Ala Glu Asn Asp Ser Ser Ser Asp Glu 
        595                 600                 605             


Gly Ser Gln Glu Leu Glu Glu Ser Ile Thr Val Asp Pro Ile Pro Thr 
    610                 615                 620                 


Glu Pro Leu Ser His Gly Ser Thr Thr Ser Tyr Lys Lys Ser Leu Arg 
625                 630                 635                 640 


Leu Ser Ser Asp Gln Ile Ala Lys Leu Lys Leu His Asp Gly Pro Asn 
                645                 650                 655     


Asp Val Val Phe Ser Ile Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys 
            660                 665                 670         


Ala Gly Thr Ile Tyr Leu Trp Asn Trp Asn Asp Lys Ile Ile Ile Ser 
        675                 680                 685             


Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu Gly Gln Ile Leu 
    690                 695                 700                 


Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr 
705                 710                 715                 720 


His Ser Ile Asn Glu Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg 
                725                 730                 735     


Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn 
            740                 745                 750         


Asp Lys Gly Thr Ile Leu Pro Arg Gly Pro Leu Met Leu Ser Pro Ser 
        755                 760                 765             


Ser Leu Phe Ser Ala Phe His Arg Glu Val Ile Glu Lys Lys Pro Glu 
    770                 775                 780                 


Lys Phe Lys Ile Glu Cys Leu Asn Asp Ile Lys Asn Leu Phe Ala Pro 
785                 790                 795                 800 


Ser Lys Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg Pro Asn Asp Val 
                805                 810                 815     


Tyr Ala Tyr Thr Gln Val Gly Val Pro Asp Cys Arg Ile Phe Thr Val 
            820                 825                 830         


Asn Pro Lys Gly Glu Leu Ile Gln Glu Arg Thr Lys Gly Asn Lys Ser 
        835                 840                 845             


Ser Tyr His Arg Leu Ser Glu Leu Val Glu His Val Phe Pro Leu Leu 
    850                 855                 860                 


Ser Lys Glu Gln Asn Ser Ala Phe Pro Cys Pro Glu Phe Ser Ser Phe 
865                 870                 875                 880 


Cys Tyr Trp Arg Asp Pro Ile Pro Glu Val Asp Leu Asp Asp Leu Ser 
                885                 890                 895     


<210>  141
<211>  344
<212>  PRT
<213>  Homo sapiens;

<400>  141

Met Ala Ala Ala Thr Glu Leu Asn Arg Pro Ser Ser Gly Asp Arg Asn 
1               5                   10                  15      


Leu Glu Arg Arg Cys Arg Pro Asn Leu Ser Arg Glu Val Leu Tyr Glu 
            20                  25                  30          


Ile Phe Arg Ser Leu His Thr Leu Val Gly Gln Leu Asp Leu Arg Asp 
        35                  40                  45              


Asp Val Val Lys Ile Thr Ile Asp Trp Asn Lys Leu Gln Ser Leu Ser 
    50                  55                  60                  


Ala Phe Gln Pro Ala Leu Leu Phe Ser Ala Leu Glu Gln His Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Pro Phe Leu Ala Lys Leu Gln Ser Pro Ile Lys Glu Glu 
                85                  90                  95      


Asn Thr Thr Ala Val Glu Glu Ile Gly Arg Thr Glu Met Gly Asn Lys 
            100                 105                 110         


Asn Glu Val Asn Asp Lys Phe Ser Ile Gly Asp Leu Gln Glu Glu Glu 
        115                 120                 125             


Lys His Lys Glu Ser Asp Leu Arg Asp Val Lys Lys Thr Gln Ile His 
    130                 135                 140                 


Phe Asp Pro Glu Val Val Gln Ile Lys Ala Gly Lys Ala Glu Ile Asp 
145                 150                 155                 160 


Arg Arg Ile Ser Ala Phe Ile Glu Arg Lys Gln Ala Glu Ile Asn Glu 
                165                 170                 175     


Asn Asn Val Arg Glu Phe Cys Asn Val Ile Asp Cys Asn Gln Glu Asn 
            180                 185                 190         


Ser Cys Ala Arg Thr Asp Ala Ile Phe Thr Pro Tyr Pro Gly Phe Lys 
        195                 200                 205             


Ser His Val Lys Val Ser Arg Val Val Asn Thr Tyr Gly Pro Gln Thr 
    210                 215                 220                 


Arg Pro Glu Gly Ile Pro Gly Ser Gly His Lys Pro Asn Ser Met Leu 
225                 230                 235                 240 


Arg Asp Cys Gly Asn Gln Ala Val Glu Glu Arg Leu Gln Asn Ile Glu 
                245                 250                 255     


Ala His Leu Arg Leu Gln Thr Gly Gly Pro Val Pro Arg Asp Ile Tyr 
            260                 265                 270         


Gln Arg Ile Lys Lys Leu Glu Asp Lys Ile Leu Glu Leu Glu Gly Ile 
        275                 280                 285             


Ser Pro Glu Tyr Phe Gln Ser Val Ser Phe Ser Gly Lys Arg Arg Lys 
    290                 295                 300                 


Val Gln Pro Pro Gln Gln Asn Tyr Ser Leu Ala Glu Leu Asp Glu Lys 
305                 310                 315                 320 


Ile Ser Ala Leu Lys Gln Ala Leu Leu Arg Lys Ser Arg Glu Ala Glu 
                325                 330                 335     


Ser Met Ala Thr His His Leu Pro 
            340                 


<210>  142
<211>  999
<212>  PRT
<213>  Homo sapiens;

<400>  142

Met Glu Pro Arg Ala Ala Ala Ala Gly Glu Pro Glu Pro Pro Ala Ala 
1               5                   10                  15      


Ser Ser Ser Phe Gln Ala Arg Leu Trp Lys Asn Leu Gln Leu Gly Val 
            20                  25                  30          


Gly Arg Ser Lys Gly Gly Gly Gly Gly Arg Ala Gly Gly Pro Glu Arg 
        35                  40                  45              


Arg Thr Ala Asp Thr Pro Ser Pro Ser Pro Pro Pro Pro Val Gly Thr 
    50                  55                  60                  


Gly Asn Ala Pro Ala Arg Gly Ser Gly Ala Gly Ser Arg Trp Ser Gly 
65                  70                  75                  80  


Phe Lys Lys Arg Lys Gln Val Leu Asp Arg Val Phe Ser Ser Ser Gln 
                85                  90                  95      


Pro Asn Leu Cys Cys Ser Ser Pro Glu Pro Leu Glu Pro Gly Gly Ala 
            100                 105                 110         


Gly Arg Ala Glu Gln Gly Ser Thr Leu Arg Arg Arg Ile Arg Glu His 
        115                 120                 125             


Leu Leu Pro Ala Val Lys Gly Pro Ala Ala Ala Ser Gly Ala Ala Gly 
    130                 135                 140                 


Gly Thr Pro Pro Gly Gly Arg Ser Pro Asp Ser Ala Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Leu Ser Ser Ser Pro Gln Pro Pro Pro Arg Gly 
                165                 170                 175     


Asp Arg Ala Arg Asp Glu Gly Ala Arg Arg Gln Gly Pro Gly Ala His 
            180                 185                 190         


Leu Cys His Gln Lys Ser Ser Ser Leu Pro Gly Thr Ala Cys Leu Glu 
        195                 200                 205             


Gln Leu Leu Glu Pro Pro Pro Pro Pro Ala Glu Pro Ala Arg Ser Pro 
    210                 215                 220                 


Ala Glu Ser Arg Ala Pro Glu Thr Gly Glu Glu His Gly Ser Ser Gln 
225                 230                 235                 240 


Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val Pro Leu Ala 
                245                 250                 255     


Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg Gly Gln Ser 
            260                 265                 270         


Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr Val Lys Phe 
        275                 280                 285             


Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile His Lys Asn 
    290                 295                 300                 


Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val Asp His Leu 
305                 310                 315                 320 


Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe Gly Leu Gln 
                325                 330                 335     


Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln Leu Glu Leu 
            340                 345                 350         


Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro His Tyr Pro 
        355                 360                 365             


Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu Thr Pro Lys 
    370                 375                 380                 


Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys Ser Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly Ser Tyr Phe 
                405                 410                 415     


Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro Ala Leu Pro 
            420                 425                 430         


Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr Cys Lys Asn 
        435                 440                 445             


Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu His Arg Lys 
    450                 455                 460                 


Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile Glu Gly Arg 
465                 470                 475                 480 


Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys 
                485                 490                 495     


Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr 
            500                 505                 510         


Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu 
        515                 520                 525             


Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys 
    530                 535                 540                 


Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser 
545                 550                 555                 560 


Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly 
                565                 570                 575     


His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile 
            580                 585                 590         


Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu 
        595                 600                 605             


Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp 
    610                 615                 620                 


Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala 
625                 630                 635                 640 


Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn 
                645                 650                 655     


Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu 
            660                 665                 670         


Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu 
        675                 680                 685             


Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu 
    690                 695                 700                 


Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys 
705                 710                 715                 720 


Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val 
                725                 730                 735     


Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu 
            740                 745                 750         


Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg 
        755                 760                 765             


Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys 
    770                 775                 780                 


Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp 
785                 790                 795                 800 


Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe 
                805                 810                 815     


Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu 
            820                 825                 830         


Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg 
        835                 840                 845             


Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu 
    850                 855                 860                 


Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys 
865                 870                 875                 880 


Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp 
                885                 890                 895     


Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr 
            900                 905                 910         


Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr 
        915                 920                 925             


Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly 
    930                 935                 940                 


Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn 
945                 950                 955                 960 


Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val 
                965                 970                 975     


Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys 
            980                 985                 990         


Arg Lys Lys Asn Asn Leu Gly 
        995                 


<210>  143
<211>  1857
<212>  PRT
<213>  Homo sapiens;

<400>  143

Met Ala Arg Lys Lys Leu Lys Lys Phe Thr Thr Leu Glu Ile Val Leu 
1               5                   10                  15      


Ser Val Leu Leu Leu Val Leu Phe Ile Ile Ser Ile Val Leu Ile Val 
            20                  25                  30          


Leu Leu Ala Lys Glu Ser Leu Lys Ser Thr Ala Pro Asp Pro Gly Thr 
        35                  40                  45              


Thr Gly Thr Pro Asp Pro Gly Thr Thr Gly Thr Pro Asp Pro Gly Thr 
    50                  55                  60                  


Thr Gly Thr Thr His Ala Arg Thr Thr Gly Pro Pro Asp Pro Gly Thr 
65                  70                  75                  80  


Thr Gly Thr Thr Pro Val Ser Ala Glu Cys Pro Val Val Asn Glu Leu 
                85                  90                  95      


Glu Arg Ile Asn Cys Ile Pro Asp Gln Pro Pro Thr Lys Ala Thr Cys 
            100                 105                 110         


Asp Gln Arg Gly Cys Cys Trp Asn Pro Gln Gly Ala Val Ser Val Pro 
        115                 120                 125             


Trp Cys Tyr Tyr Ser Lys Asn His Ser Tyr His Val Glu Gly Asn Leu 
    130                 135                 140                 


Val Asn Thr Asn Ala Gly Phe Thr Ala Arg Leu Lys Asn Leu Pro Ser 
145                 150                 155                 160 


Ser Pro Val Phe Gly Ser Asn Val Asp Asn Val Leu Leu Thr Ala Glu 
                165                 170                 175     


Tyr Gln Thr Ser Asn Arg Phe His Phe Lys Leu Thr Asp Gln Thr Asn 
            180                 185                 190         


Asn Arg Phe Glu Val Pro His Glu His Val Gln Ser Phe Ser Gly Asn 
        195                 200                 205             


Ala Ala Ala Ser Leu Thr Tyr Gln Val Glu Ile Ser Arg Gln Pro Phe 
    210                 215                 220                 


Ser Ile Lys Val Thr Arg Arg Ser Asn Asn Arg Val Leu Phe Asp Ser 
225                 230                 235                 240 


Ser Ile Gly Pro Leu Leu Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                245                 250                 255     


Arg Leu Pro Ser Thr Asn Val Tyr Gly Leu Gly Glu His Val His Gln 
            260                 265                 270         


Gln Tyr Arg His Asp Met Asn Trp Lys Thr Trp Pro Ile Phe Asn Arg 
        275                 280                 285             


Asp Thr Thr Pro Asn Gly Asn Gly Thr Asn Leu Tyr Gly Ala Gln Thr 
    290                 295                 300                 


Phe Phe Leu Cys Leu Glu Asp Ala Ser Gly Leu Ser Phe Gly Val Phe 
305                 310                 315                 320 


Leu Met Asn Ser Asn Ala Met Glu Val Val Leu Gln Pro Ala Pro Ala 
                325                 330                 335     


Ile Thr Tyr Arg Thr Ile Gly Gly Ile Leu Asp Phe Tyr Val Phe Leu 
            340                 345                 350         


Gly Asn Thr Pro Glu Gln Val Val Gln Glu Tyr Leu Glu Leu Ile Gly 
        355                 360                 365             


Arg Pro Ala Leu Pro Ser Tyr Trp Ala Leu Gly Phe His Leu Ser Arg 
    370                 375                 380                 


Tyr Glu Tyr Gly Thr Leu Asp Asn Met Arg Glu Val Val Glu Arg Asn 
385                 390                 395                 400 


Arg Ala Ala Gln Leu Pro Tyr Asp Val Gln His Ala Asp Ile Asp Tyr 
                405                 410                 415     


Met Asp Glu Arg Arg Asp Phe Thr Tyr Asp Ser Val Asp Phe Lys Gly 
            420                 425                 430         


Phe Pro Glu Phe Val Asn Glu Leu His Asn Asn Gly Gln Lys Leu Val 
        435                 440                 445             


Ile Ile Val Asp Pro Ala Ile Ser Asn Asn Ser Ser Ser Ser Lys Pro 
    450                 455                 460                 


Tyr Gly Pro Tyr Asp Arg Gly Ser Asp Met Lys Ile Trp Val Asn Ser 
465                 470                 475                 480 


Ser Asp Gly Val Thr Pro Leu Ile Gly Glu Val Trp Pro Gly Gln Thr 
                485                 490                 495     


Val Phe Pro Asp Tyr Thr Asn Pro Asn Cys Ala Val Trp Trp Thr Lys 
            500                 505                 510         


Glu Phe Glu Leu Phe His Asn Gln Val Glu Phe Asp Gly Ile Trp Ile 
        515                 520                 525             


Asp Met Asn Glu Val Ser Asn Phe Val Asp Gly Ser Val Ser Gly Cys 
    530                 535                 540                 


Ser Thr Asn Asn Leu Asn Asn Pro Pro Phe Thr Pro Arg Ile Leu Asp 
545                 550                 555                 560 


Gly Tyr Leu Phe Cys Lys Thr Leu Cys Met Asp Ala Val Gln His Trp 
                565                 570                 575     


Gly Lys Gln Tyr Asp Ile His Asn Leu Tyr Gly Tyr Ser Met Ala Val 
            580                 585                 590         


Ala Thr Ala Glu Ala Ala Lys Thr Val Phe Pro Asn Lys Arg Ser Phe 
        595                 600                 605             


Ile Leu Thr Arg Ser Thr Phe Ala Gly Ser Gly Lys Phe Ala Ala His 
    610                 615                 620                 


Trp Leu Gly Asp Asn Thr Ala Thr Trp Asp Asp Leu Arg Trp Ser Ile 
625                 630                 635                 640 


Pro Gly Val Leu Glu Phe Asn Leu Phe Gly Ile Pro Met Val Gly Pro 
                645                 650                 655     


Asp Ile Cys Gly Phe Ala Leu Asp Thr Pro Glu Glu Leu Cys Arg Arg 
            660                 665                 670         


Trp Met Gln Leu Gly Ala Phe Tyr Pro Phe Ser Arg Asn His Asn Gly 
        675                 680                 685             


Gln Gly Tyr Lys Asp Gln Asp Pro Ala Ser Phe Gly Ala Asp Ser Leu 
    690                 695                 700                 


Leu Leu Asn Ser Ser Arg His Tyr Leu Asn Ile Arg Tyr Thr Leu Leu 
705                 710                 715                 720 


Pro Tyr Leu Tyr Thr Leu Phe Phe Arg Ala His Ser Arg Gly Asp Thr 
                725                 730                 735     


Val Ala Arg Pro Leu Leu His Glu Phe Tyr Glu Asp Asn Ser Thr Trp 
            740                 745                 750         


Asp Val His Gln Gln Phe Leu Trp Gly Pro Gly Leu Leu Ile Thr Pro 
        755                 760                 765             


Val Leu Asp Glu Gly Ala Glu Lys Val Met Ala Tyr Val Pro Asp Ala 
    770                 775                 780                 


Val Trp Tyr Asp Tyr Glu Thr Gly Ser Gln Val Arg Trp Arg Lys Gln 
785                 790                 795                 800 


Lys Val Glu Met Glu Leu Pro Gly Asp Lys Ile Gly Leu His Leu Arg 
                805                 810                 815     


Gly Gly Tyr Ile Phe Pro Thr Gln Gln Pro Asn Thr Thr Thr Leu Ala 
            820                 825                 830         


Ser Arg Lys Asn Pro Leu Gly Leu Ile Ile Ala Leu Asp Glu Asn Lys 
        835                 840                 845             


Glu Ala Lys Gly Glu Leu Phe Trp Asp Asn Gly Glu Thr Lys Asp Thr 
    850                 855                 860                 


Val Ala Asn Lys Val Tyr Leu Leu Cys Glu Phe Ser Val Thr Gln Asn 
865                 870                 875                 880 


Arg Leu Glu Val Asn Ile Ser Gln Ser Thr Tyr Lys Asp Pro Asn Asn 
                885                 890                 895     


Leu Ala Phe Asn Glu Ile Lys Ile Leu Gly Thr Glu Glu Pro Ser Asn 
            900                 905                 910         


Val Thr Val Lys His Asn Gly Val Pro Ser Gln Thr Ser Pro Thr Val 
        915                 920                 925             


Thr Tyr Asp Ser Asn Leu Lys Val Ala Ile Ile Thr Asp Ile Asp Leu 
    930                 935                 940                 


Leu Leu Gly Glu Ala Tyr Thr Val Glu Trp Ser Ile Lys Ile Arg Asp 
945                 950                 955                 960 


Glu Glu Lys Ile Asp Cys Tyr Pro Asp Glu Asn Gly Ala Ser Ala Glu 
                965                 970                 975     


Asn Cys Thr Ala Arg Gly Cys Ile Trp Glu Ala Ser Asn Ser Ser Gly 
            980                 985                 990         


Val Pro Phe Cys Tyr Phe Val Asn  Asp Leu Tyr Ser Val  Ser Asp Val 
        995                 1000                 1005             


Gln Tyr  Asn Ser His Gly Ala  Thr Ala Asp Ile Ser  Leu Lys Ser 
    1010                 1015                 1020             


Ser Val  Tyr Ala Asn Ala Phe  Pro Ser Thr Pro Val  Asn Pro Leu 
    1025                 1030                 1035             


Arg Leu  Asp Val Thr Tyr His  Lys Asn Glu Met Leu  Gln Phe Lys 
    1040                 1045                 1050             


Ile Tyr  Asp Pro Asn Lys Asn  Arg Tyr Glu Val Pro  Val Pro Leu 
    1055                 1060                 1065             


Asn Ile  Pro Ser Met Pro Ser  Ser Thr Pro Glu Gly  Gln Leu Tyr 
    1070                 1075                 1080             


Asp Val  Leu Ile Lys Lys Asn  Pro Phe Gly Ile Glu  Ile Arg Arg 
    1085                 1090                 1095             


Lys Ser  Thr Gly Thr Ile Ile  Trp Asp Ser Gln Leu  Leu Gly Phe 
    1100                 1105                 1110             


Thr Phe  Ser Asp Met Phe Ile  Arg Ile Ser Thr Arg  Leu Pro Ser 
    1115                 1120                 1125             


Lys Tyr  Leu Tyr Gly Phe Gly  Glu Thr Glu His Arg  Ser Tyr Arg 
    1130                 1135                 1140             


Arg Asp  Leu Glu Trp His Thr  Trp Gly Met Phe Ser  Arg Asp Gln 
    1145                 1150                 1155             


Pro Pro  Gly Tyr Lys Lys Asn  Ser Tyr Gly Val His  Pro Tyr Tyr 
    1160                 1165                 1170             


Met Gly  Leu Glu Glu Asp Gly  Ser Ala His Gly Val  Leu Leu Leu 
    1175                 1180                 1185             


Asn Ser  Asn Ala Met Asp Val  Thr Phe Gln Pro Leu  Pro Ala Leu 
    1190                 1195                 1200             


Thr Tyr  Arg Thr Thr Gly Gly  Val Leu Asp Phe Tyr  Val Phe Leu 
    1205                 1210                 1215             


Gly Pro  Thr Pro Glu Leu Val  Thr Gln Gln Tyr Thr  Glu Leu Ile 
    1220                 1225                 1230             


Gly Arg  Pro Val Met Val Pro  Tyr Trp Ser Leu Gly  Phe Gln Leu 
    1235                 1240                 1245             


Cys Arg  Tyr Gly Tyr Gln Asn  Asp Ser Glu Ile Ala  Ser Leu Tyr 
    1250                 1255                 1260             


Asp Glu  Met Val Ala Ala Gln  Ile Pro Tyr Asp Val  Gln Tyr Ser 
    1265                 1270                 1275             


Asp Ile  Asp Tyr Met Glu Arg  Gln Leu Asp Phe Thr  Leu Ser Pro 
    1280                 1285                 1290             


Lys Phe  Ala Gly Phe Pro Ala  Leu Ile Asn Arg Met  Lys Ala Asp 
    1295                 1300                 1305             


Gly Met  Arg Val Ile Leu Ile  Leu Asp Pro Ala Ile  Ser Gly Asn 
    1310                 1315                 1320             


Glu Thr  Gln Pro Tyr Pro Ala  Phe Thr Arg Gly Val  Glu Asp Asp 
    1325                 1330                 1335             


Val Phe  Ile Lys Tyr Pro Asn  Asp Gly Asp Ile Val  Trp Gly Lys 
    1340                 1345                 1350             


Val Trp  Pro Asp Phe Pro Asp  Val Val Val Asn Gly  Ser Leu Asp 
    1355                 1360                 1365             


Trp Asp  Ser Gln Val Glu Leu  Tyr Arg Ala Tyr Val  Ala Phe Pro 
    1370                 1375                 1380             


Asp Phe  Phe Arg Asn Ser Thr  Ala Lys Trp Trp Lys  Arg Glu Ile 
    1385                 1390                 1395             


Glu Glu  Leu Tyr Asn Asn Pro  Gln Asn Pro Glu Arg  Ser Leu Lys 
    1400                 1405                 1410             


Phe Asp  Gly Met Trp Ile Asp  Met Asn Glu Pro Ser  Ser Phe Val 
    1415                 1420                 1425             


Asn Gly  Ala Val Ser Pro Gly  Cys Arg Asp Ala Ser  Leu Asn His 
    1430                 1435                 1440             


Pro Pro  Tyr Met Pro His Leu  Glu Ser Arg Asp Arg  Gly Leu Ser 
    1445                 1450                 1455             


Ser Lys  Thr Leu Cys Met Glu  Ser Gln Gln Ile Leu  Pro Asp Gly 
    1460                 1465                 1470             


Ser Leu  Val Gln His Tyr Asn  Val His Asn Leu Tyr  Gly Trp Ser 
    1475                 1480                 1485             


Gln Thr  Arg Pro Thr Tyr Glu  Ala Val Gln Glu Val  Thr Gly Gln 
    1490                 1495                 1500             


Arg Gly  Val Val Ile Thr Arg  Ser Thr Phe Pro Ser  Ser Gly Arg 
    1505                 1510                 1515             


Trp Ala  Gly His Trp Leu Gly  Asp Asn Thr Ala Ala  Trp Asp Gln 
    1520                 1525                 1530             


Leu Lys  Lys Ser Ile Ile Gly  Met Met Glu Phe Ser  Leu Phe Gly 
    1535                 1540                 1545             


Ile Ser  Tyr Thr Gly Ala Asp  Ile Cys Gly Phe Phe  Gln Asp Ala 
    1550                 1555                 1560             


Glu Tyr  Glu Met Cys Val Arg  Trp Met Gln Leu Gly  Ala Phe Tyr 
    1565                 1570                 1575             


Pro Phe  Ser Arg Asn His Asn  Thr Ile Gly Thr Arg  Arg Gln Asp 
    1580                 1585                 1590             


Pro Val  Ser Trp Asp Val Ala  Phe Val Asn Ile Ser  Arg Thr Val 
    1595                 1600                 1605             


Leu Gln  Thr Arg Tyr Thr Leu  Leu Pro Tyr Leu Tyr  Thr Leu Met 
    1610                 1615                 1620             


His Lys  Ala His Thr Glu Gly  Val Thr Val Val Arg  Pro Leu Leu 
    1625                 1630                 1635             


His Glu  Phe Val Ser Asp Gln  Val Thr Trp Asp Ile  Asp Ser Gln 
    1640                 1645                 1650             


Phe Leu  Leu Gly Pro Ala Phe  Leu Val Ser Pro Val  Leu Glu Arg 
    1655                 1660                 1665             


Asn Ala  Arg Asn Val Thr Ala  Tyr Phe Pro Arg Ala  Arg Trp Tyr 
    1670                 1675                 1680             


Asp Tyr  Tyr Thr Gly Val Asp  Ile Asn Ala Arg Gly  Glu Trp Lys 
    1685                 1690                 1695             


Thr Leu  Pro Ala Pro Leu Asp  His Ile Asn Leu His  Val Arg Gly 
    1700                 1705                 1710             


Gly Tyr  Ile Leu Pro Trp Gln  Glu Pro Ala Leu Asn  Thr His Leu 
    1715                 1720                 1725             


Ser Arg  Gln Lys Phe Met Gly  Phe Lys Ile Ala Leu  Asp Asp Glu 
    1730                 1735                 1740             


Gly Thr  Ala Gly Gly Trp Leu  Phe Trp Asp Asp Gly  Gln Ser Ile 
    1745                 1750                 1755             


Asp Thr  Tyr Gly Lys Gly Leu  Tyr Tyr Leu Ala Ser  Phe Ser Ala 
    1760                 1765                 1770             


Ser Gln  Asn Thr Met Gln Ser  His Ile Ile Phe Asn  Asn Tyr Ile 
    1775                 1780                 1785             


Thr Gly  Thr Asn Pro Leu Lys  Leu Gly Tyr Ile Glu  Ile Trp Gly 
    1790                 1795                 1800             


Val Gly  Ser Val Pro Val Thr  Ser Val Ser Ile Ser  Val Ser Gly 
    1805                 1810                 1815             


Met Val  Ile Thr Pro Ser Phe  Asn Asn Asp Pro Thr  Thr Gln Val 
    1820                 1825                 1830             


Leu Ser  Ile Asp Val Thr Asp  Arg Asn Ile Ser Leu  His Asn Phe 
    1835                 1840                 1845             


Thr Ser  Leu Thr Trp Ile Ser  Thr Leu 
    1850                 1855         


<210>  144
<211>  750
<212>  PRT
<213>  Homo sapiens;

<400>  144

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  145
<211>  2063
<212>  PRT
<213>  Homo sapiens;

<400>  145

Met Val Leu Asp Asp Leu Pro Asn Leu Glu Asp Ile Tyr Thr Ser Leu 
1               5                   10                  15      


Cys Ser Ser Thr Met Glu Asp Ser Glu Met Asp Phe Asp Ser Gly Leu 
            20                  25                  30          


Glu Asp Asp Asp Thr Lys Ser Asp Ser Ile Leu Glu Asp Ser Thr Ile 
        35                  40                  45              


Phe Val Ala Phe Lys Gly Asn Ile Asp Asp Lys Asp Phe Lys Trp Lys 
    50                  55                  60                  


Leu Asp Ala Ile Leu Lys Asn Val Pro Asn Leu Leu His Met Glu Ser 
65                  70                  75                  80  


Ser Lys Leu Lys Val Gln Lys Val Glu Pro Trp Asn Ser Val Arg Val 
                85                  90                  95      


Thr Phe Asn Ile Pro Arg Glu Ala Ala Glu Arg Leu Arg Ile Leu Ala 
            100                 105                 110         


Gln Ser Asn Asn Gln Gln Leu Arg Asp Leu Gly Ile Leu Ser Val Gln 
        115                 120                 125             


Ile Glu Gly Glu Gly Ala Ile Asn Leu Ala Leu Ala Gln Asn Arg Ser 
    130                 135                 140                 


Gln Asp Val Arg Met Asn Gly Pro Met Gly Ala Gly Asn Ser Val Arg 
145                 150                 155                 160 


Met Glu Ala Gly Phe Pro Met Ala Ser Gly Pro Gly Ile Ile Arg Met 
                165                 170                 175     


Asn Asn Pro Ala Thr Val Met Ile Pro Pro Gly Gly Asn Val Ser Ser 
            180                 185                 190         


Ser Met Met Ala Pro Gly Pro Asn Pro Glu Leu Gln Pro Arg Thr Pro 
        195                 200                 205             


Arg Pro Ala Ser Gln Ser Asp Ala Met Asp Pro Leu Leu Ser Gly Leu 
    210                 215                 220                 


His Ile Gln Gln Gln Ser His Pro Ser Gly Ser Leu Ala Pro Pro His 
225                 230                 235                 240 


His Pro Met Gln Pro Val Ser Val Asn Arg Gln Met Asn Pro Ala Asn 
                245                 250                 255     


Phe Pro Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Ala 
        275                 280                 285             


Arg Pro Pro Gln Gln His Gln Gln Gln Gln Pro Gln Gly Ile Arg Pro 
    290                 295                 300                 


Gln Phe Thr Ala Pro Thr Gln Val Pro Val Pro Pro Gly Trp Asn Gln 
305                 310                 315                 320 


Leu Pro Ser Gly Ala Leu Gln Pro Pro Pro Ala Gln Gly Ser Leu Gly 
                325                 330                 335     


Thr Met Thr Ala Asn Gln Gly Trp Lys Lys Ala Pro Leu Pro Gly Pro 
            340                 345                 350         


Met Gln Gln Gln Leu Gln Ala Arg Pro Ser Leu Ala Thr Val Gln Thr 
        355                 360                 365             


Pro Ser His Pro Pro Pro Pro Tyr Pro Phe Gly Ser Gln Gln Ala Ser 
    370                 375                 380                 


Gln Ala His Thr Asn Phe Pro Gln Met Ser Asn Pro Gly Gln Phe Thr 
385                 390                 395                 400 


Ala Pro Gln Met Lys Ser Leu Gln Gly Gly Pro Ser Arg Val Pro Thr 
                405                 410                 415     


Pro Leu Gln Gln Pro His Leu Thr Asn Lys Ser Pro Ala Ser Ser Pro 
            420                 425                 430         


Ser Ser Phe Gln Gln Gly Ser Pro Ala Ser Ser Pro Thr Val Asn Gln 
        435                 440                 445             


Thr Gln Gln Gln Met Gly Pro Arg Pro Pro Gln Asn Asn Pro Leu Pro 
    450                 455                 460                 


Gln Gly Phe Gln Gln Pro Val Ser Ser Pro Gly Arg Asn Pro Met Val 
465                 470                 475                 480 


Gln Gln Gly Asn Val Pro Pro Asn Phe Met Val Met Gln Gln Gln Pro 
                485                 490                 495     


Pro Asn Gln Gly Pro Gln Ser Leu His Pro Gly Leu Gly Gly Met Pro 
            500                 505                 510         


Lys Arg Leu Pro Pro Gly Phe Ser Ala Gly Gln Ala Asn Pro Asn Phe 
        515                 520                 525             


Met Gln Gly Gln Val Pro Ser Thr Thr Ala Thr Thr Pro Gly Asn Ser 
    530                 535                 540                 


Gly Ala Pro Gln Leu Gln Ala Asn Gln Asn Val Gln His Ala Gly Gly 
545                 550                 555                 560 


Gln Gly Ala Gly Pro Pro Gln Asn Gln Met Gln Val Ser His Gly Pro 
                565                 570                 575     


Pro Asn Met Met Gln Pro Ser Leu Met Gly Ile His Gly Asn Met Asn 
            580                 585                 590         


Asn Gln Gln Ala Gly Thr Ser Gly Val Pro Gln Val Asn Leu Ser Asn 
        595                 600                 605             


Met Gln Gly Gln Pro Gln Gln Gly Pro Pro Ser Gln Leu Met Gly Met 
    610                 615                 620                 


His Gln Gln Ile Val Pro Ser Gln Gly Gln Met Val Gln Gln Gln Gly 
625                 630                 635                 640 


Thr Leu Asn Pro Gln Asn Pro Met Ile Leu Ser Arg Ala Gln Leu Met 
                645                 650                 655     


Pro Gln Gly Gln Met Met Val Asn Pro Pro Ser Gln Asn Leu Gly Pro 
            660                 665                 670         


Ser Pro Gln Arg Met Thr Pro Pro Lys Gln Met Leu Ser Gln Gln Gly 
        675                 680                 685             


Pro Gln Met Met Ala Pro His Asn Gln Met Met Gly Pro Gln Gly Gln 
    690                 695                 700                 


Val Leu Leu Gln Gln Asn Pro Met Ile Glu Gln Ile Met Thr Asn Gln 
705                 710                 715                 720 


Met Gln Gly Asn Lys Gln Gln Phe Asn Thr Gln Asn Gln Ser Asn Val 
                725                 730                 735     


Met Pro Gly Pro Ala Gln Ile Met Arg Gly Pro Thr Pro Asn Met Gln 
            740                 745                 750         


Gly Asn Met Val Gln Phe Thr Gly Gln Met Ser Gly Gln Met Leu Pro 
        755                 760                 765             


Gln Gln Gly Pro Val Asn Asn Ser Pro Ser Gln Val Met Gly Ile Gln 
    770                 775                 780                 


Gly Gln Val Leu Arg Pro Pro Gly Pro Ser Pro His Met Ala Gln Gln 
785                 790                 795                 800 


His Gly Asp Pro Ala Thr Thr Ala Asn Asn Asp Val Ser Leu Ser Gln 
                805                 810                 815     


Met Met Pro Asp Val Ser Ile Gln Gln Thr Asn Met Val Pro Pro His 
            820                 825                 830         


Val Gln Ala Met Gln Gly Asn Ser Ala Ser Gly Asn His Phe Ser Gly 
        835                 840                 845             


His Gly Met Ser Phe Asn Ala Pro Phe Ser Gly Ala Pro Asn Gly Asn 
    850                 855                 860                 


Gln Met Ser Cys Gly Gln Asn Pro Gly Phe Pro Val Asn Lys Asp Val 
865                 870                 875                 880 


Thr Leu Thr Ser Pro Leu Leu Val Asn Leu Leu Gln Ser Asp Ile Ser 
                885                 890                 895     


Ala Gly His Phe Gly Val Asn Asn Lys Gln Asn Asn Thr Asn Ala Asn 
            900                 905                 910         


Lys Pro Lys Lys Lys Lys Pro Pro Arg Lys Lys Lys Asn Ser Gln Gln 
        915                 920                 925             


Asp Leu Asn Thr Pro Asp Thr Arg Pro Ala Gly Leu Glu Glu Ala Asp 
    930                 935                 940                 


Gln Pro Pro Leu Pro Gly Glu Gln Gly Ile Asn Leu Asp Asn Ser Gly 
945                 950                 955                 960 


Pro Lys Leu Pro Glu Phe Ser Asn Arg Pro Pro Gly Tyr Pro Ser Gln 
                965                 970                 975     


Pro Val Glu Gln Arg Pro Leu Gln Gln Met Pro Pro Gln Leu Met Gln 
            980                 985                 990         


His Val Ala Pro Pro Pro Gln Pro  Pro Gln Gln Gln Pro  Gln Pro Gln 
        995                 1000                 1005             


Leu Pro  Gln Gln Gln Gln Pro  Pro Pro Pro Ser Gln  Pro Gln Ser 
    1010                 1015                 1020             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Met Met Met  Met Leu Met 
    1025                 1030                 1035             


Met Gln  Gln Asp Pro Lys Ser  Val Arg Leu Pro Val  Ser Gln Asn 
    1040                 1045                 1050             


Val His  Pro Pro Arg Gly Pro  Leu Asn Pro Asp Ser  Gln Arg Met 
    1055                 1060                 1065             


Pro Met  Gln Gln Ser Gly Ser  Val Pro Val Met Val  Ser Leu Gln 
    1070                 1075                 1080             


Gly Pro  Ala Ser Val Pro Pro  Ser Pro Asp Lys Gln  Arg Met Pro 
    1085                 1090                 1095             


Met Pro  Val Asn Thr Pro Leu  Gly Ser Asn Ser Arg  Lys Met Val 
    1100                 1105                 1110             


Tyr Gln  Glu Ser Pro Gln Asn  Pro Ser Ser Ser Pro  Leu Ala Glu 
    1115                 1120                 1125             


Met Ala  Ser Leu Pro Glu Ala  Ser Gly Ser Glu Ala  Pro Ser Val 
    1130                 1135                 1140             


Pro Gly  Gly Pro Asn Asn Met  Pro Ser His Val Val  Leu Pro Gln 
    1145                 1150                 1155             


Asn Gln  Leu Met Met Thr Gly  Pro Lys Pro Gly Pro  Ser Pro Leu 
    1160                 1165                 1170             


Ser Ala  Thr Gln Gly Ala Thr  Pro Gln Gln Pro Pro  Val Asn Ser 
    1175                 1180                 1185             


Leu Pro  Ser Ser His Gly His  His Phe Pro Asn Val  Ala Ala Pro 
    1190                 1195                 1200             


Thr Gln  Thr Ser Arg Pro Lys  Thr Pro Asn Arg Ala  Ser Pro Arg 
    1205                 1210                 1215             


Pro Tyr  Tyr Pro Gln Thr Pro  Asn Asn Arg Pro Pro  Ser Thr Glu 
    1220                 1225                 1230             


Pro Ser  Glu Ile Ser Leu Ser  Pro Glu Arg Leu Asn  Ala Ser Ile 
    1235                 1240                 1245             


Ala Gly  Leu Phe Pro Pro Gln  Ile Asn Ile Pro Leu  Pro Pro Arg 
    1250                 1255                 1260             


Pro Asn  Leu Asn Arg Gly Phe  Asp Gln Gln Gly Leu  Asn Pro Thr 
    1265                 1270                 1275             


Thr Leu  Lys Ala Ile Gly Gln  Ala Pro Ser Asn Leu  Thr Met Asn 
    1280                 1285                 1290             


Pro Ser  Asn Phe Ala Thr Pro  Gln Thr His Lys Leu  Asp Ser Val 
    1295                 1300                 1305             


Val Val  Asn Ser Gly Lys Gln  Ser Asn Ser Gly Ala  Thr Lys Arg 
    1310                 1315                 1320             


Ala Ser  Pro Ser Asn Ser Arg  Arg Ser Ser Pro Gly  Ser Ser Arg 
    1325                 1330                 1335             


Lys Thr  Thr Pro Ser Pro Gly  Arg Gln Asn Ser Lys  Ala Pro Lys 
    1340                 1345                 1350             


Leu Thr  Leu Ala Ser Gln Thr  Asn Ala Ala Leu Leu  Gln Asn Val 
    1355                 1360                 1365             


Glu Leu  Pro Arg Asn Val Leu  Val Ser Pro Thr Pro  Leu Ala Asn 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Ser Phe  Pro Asn Asn Ser Gly  Leu Asn Pro 
    1385                 1390                 1395             


Gln Asn  Ser Thr Val Ser Val  Ala Ala Val Gly Gly  Val Val Glu 
    1400                 1405                 1410             


Asp Asn  Lys Glu Ser Leu Asn  Val Pro Gln Asp Ser  Asp Cys Gln 
    1415                 1420                 1425             


Asn Ser  Gln Ser Arg Lys Glu  Gln Val Asn Ile Glu  Leu Lys Ala 
    1430                 1435                 1440             


Val Pro  Ala Gln Glu Val Lys  Met Val Val Pro Glu  Asp Gln Ser 
    1445                 1450                 1455             


Lys Lys  Asp Gly Gln Pro Ser  Asp Pro Asn Lys Leu  Pro Ser Val 
    1460                 1465                 1470             


Glu Glu  Asn Lys Asn Leu Val  Ser Pro Ala Met Arg  Glu Ala Pro 
    1475                 1480                 1485             


Thr Ser  Leu Ser Gln Leu Leu  Asp Asn Ser Gly Ala  Pro Asn Val 
    1490                 1495                 1500             


Thr Ile  Lys Pro Pro Gly Leu  Thr Asp Leu Glu Val  Thr Pro Pro 
    1505                 1510                 1515             


Val Val  Ser Gly Glu Asp Leu  Lys Lys Ala Ser Val  Ile Pro Thr 
    1520                 1525                 1530             


Leu Gln  Asp Leu Ser Ser Ser  Lys Glu Pro Ser Asn  Ser Leu Asn 
    1535                 1540                 1545             


Leu Pro  His Ser Asn Glu Leu  Cys Ser Ser Leu Val  His Pro Glu 
    1550                 1555                 1560             


Leu Ser  Glu Val Ser Ser Asn  Val Ala Pro Ser Ile  Pro Pro Val 
    1565                 1570                 1575             


Met Ser  Arg Pro Val Ser Ser  Ser Ser Ile Ser Thr  Pro Leu Pro 
    1580                 1585                 1590             


Pro Asn  Gln Ile Thr Val Phe  Val Thr Ser Asn Pro  Ile Thr Thr 
    1595                 1600                 1605             


Ser Ala  Asn Thr Ser Ala Ala  Leu Pro Thr His Leu  Gln Ser Ala 
    1610                 1615                 1620             


Leu Met  Ser Thr Val Val Thr  Met Pro Asn Ala Gly  Ser Lys Val 
    1625                 1630                 1635             


Met Val  Ser Glu Gly Gln Ser  Ala Ala Gln Ser Asn  Ala Arg Pro 
    1640                 1645                 1650             


Gln Phe  Ile Thr Pro Val Phe  Ile Asn Ser Ser Ser  Ile Ile Gln 
    1655                 1660                 1665             


Val Met  Lys Gly Ser Gln Pro  Ser Thr Ile Pro Ala  Ala Pro Leu 
    1670                 1675                 1680             


Thr Thr  Asn Ser Gly Leu Met  Pro Pro Ser Val Ala  Val Val Gly 
    1685                 1690                 1695             


Pro Leu  His Ile Pro Gln Asn  Ile Lys Phe Ser Ser  Ala Pro Val 
    1700                 1705                 1710             


Pro Pro  Asn Ala Leu Ser Ser  Ser Pro Ala Pro Asn  Ile Gln Thr 
    1715                 1720                 1725             


Gly Arg  Pro Leu Val Leu Ser  Ser Arg Ala Thr Pro  Val Gln Leu 
    1730                 1735                 1740             


Pro Ser  Pro Pro Cys Thr Ser  Ser Pro Val Val Pro  Ser His Pro 
    1745                 1750                 1755             


Pro Val  Gln Gln Val Lys Glu  Leu Asn Pro Asp Glu  Ala Ser Pro 
    1760                 1765                 1770             


Gln Val  Asn Thr Ser Ala Asp  Gln Asn Thr Leu Pro  Ser Ser Gln 
    1775                 1780                 1785             


Ser Thr  Thr Met Val Ser Pro  Leu Leu Thr Asn Ser  Pro Gly Ser 
    1790                 1795                 1800             


Ser Gly  Asn Arg Arg Ser Pro  Val Ser Ser Ser Lys  Gly Lys Gly 
    1805                 1810                 1815             


Lys Val  Asp Lys Ile Gly Gln  Ile Leu Leu Thr Lys  Ala Cys Lys 
    1820                 1825                 1830             


Lys Val  Thr Gly Ser Leu Glu  Lys Gly Glu Glu Gln  Tyr Gly Ala 
    1835                 1840                 1845             


Asp Gly  Glu Thr Glu Gly Gln  Gly Leu Asp Thr Thr  Ala Pro Gly 
    1850                 1855                 1860             


Leu Met  Gly Thr Glu Gln Leu  Ser Thr Glu Leu Asp  Ser Lys Thr 
    1865                 1870                 1875             


Pro Thr  Pro Pro Ala Pro Thr  Leu Leu Lys Met Thr  Ser Ser Pro 
    1880                 1885                 1890             


Val Gly  Pro Gly Thr Ala Ser  Ala Gly Pro Ser Leu  Pro Gly Gly 
    1895                 1900                 1905             


Ala Leu  Pro Thr Ser Val Arg  Ser Ile Val Thr Thr  Leu Val Pro 
    1910                 1915                 1920             


Ser Glu  Leu Ile Ser Ala Val  Pro Thr Thr Lys Ser  Asn His Gly 
    1925                 1930                 1935             


Gly Ile  Ala Ser Glu Ser Leu  Ala Gly Gly Leu Val  Glu Glu Lys 
    1940                 1945                 1950             


Val Gly  Ser His Pro Glu Leu  Leu Pro Ser Ile Ala  Pro Ser Gln 
    1955                 1960                 1965             


Asn Leu  Val Ser Lys Glu Thr  Ser Thr Thr Ala Leu  Gln Ala Ser 
    1970                 1975                 1980             


Val Ala  Arg Pro Glu Leu Glu  Val Asn Ala Ala Ile  Val Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Glu Pro Lys Glu  Ile Val Glu Lys Ser  Lys Ile Pro 
    2000                 2005                 2010             


Gly Arg  Arg Asn Ser Arg Thr  Glu Glu Pro Thr Val  Ala Ser Glu 
    2015                 2020                 2025             


Ser Val  Glu Asn Gly His Arg  Lys Arg Ser Ser Arg  Pro Ala Ser 
    2030                 2035                 2040             


Ala Ser  Ser Ser Thr Lys Asp  Ile Thr Ser Ala Val  Gln Ser Lys 
    2045                 2050                 2055             


Arg Arg  Lys Ser Lys 
    2060             


<210>  146
<211>  428
<212>  PRT
<213>  Homo sapiens;

<400>  146

Met Tyr Ser Ser Pro Leu Cys Leu Thr Gln Asp Glu Phe His Pro Phe 
1               5                   10                  15      


Ile Glu Ala Leu Leu Pro His Val Arg Ala Phe Ala Tyr Thr Trp Phe 
            20                  25                  30          


Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg 
        35                  40                  45              


Met Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu 
    50                  55                  60                  


Lys Pro Glu Val Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu 
65                  70                  75                  80  


Arg Lys Asp Ile Arg Pro Glu Cys Arg Glu Asp Phe Val Leu Ser Ile 
                85                  90                  95      


Thr Gly Lys Lys Ala Pro Gly Cys Val Leu Ser Asn Pro Asp Gln Lys 
            100                 105                 110         


Gly Lys Met Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp 
        115                 120                 125             


Arg Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu 
    130                 135                 140                 


Ser Thr Asp Gly Glu Arg Leu Val Lys Ala Ala Gln Cys Gly His Pro 
145                 150                 155                 160 


Val Leu Cys Val Gln Pro His His Ile Gly Val Ala Val Lys Glu Leu 
                165                 170                 175     


Asp Leu Tyr Leu Ala Tyr Phe Val Arg Glu Arg Asp Ala Glu Gln Ser 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Met Gly Ser Asp Gln Glu Asp Ser Lys Pro 
        195                 200                 205             


Ile Thr Leu Asp Thr Thr Asp Phe Gln Glu Ser Phe Val Thr Ser Gly 
    210                 215                 220                 


Val Phe Ser Val Thr Glu Leu Ile Gln Val Ser Arg Thr Pro Val Val 
225                 230                 235                 240 


Thr Gly Thr Gly Pro Asn Phe Ser Leu Gly Glu Leu Gln Gly His Leu 
                245                 250                 255     


Ala Tyr Asp Leu Asn Pro Ala Ser Thr Gly Leu Arg Arg Thr Leu Pro 
            260                 265                 270         


Ser Thr Ser Ser Ser Gly Ser Lys Arg His Lys Ser Gly Ser Met Glu 
        275                 280                 285             


Glu Asp Val Asp Thr Ser Pro Gly Gly Asp Tyr Tyr Thr Ser Pro Ser 
    290                 295                 300                 


Ser Pro Thr Ser Ser Ser Arg Asn Trp Thr Glu Asp Met Glu Gly Gly 
305                 310                 315                 320 


Ile Ser Ser Pro Val Lys Lys Thr Glu Met Asp Lys Ser Pro Phe Asn 
                325                 330                 335     


Ser Pro Ser Pro Gln Asp Ser Pro Arg Leu Ser Ser Phe Thr Gln His 
            340                 345                 350         


His Arg Pro Val Ile Ala Val His Ser Gly Ile Ala Arg Ser Pro His 
        355                 360                 365             


Pro Ser Ser Ala Leu His Phe Pro Thr Thr Ser Ile Leu Pro Gln Thr 
    370                 375                 380                 


Ala Ser Thr Tyr Phe Pro His Thr Ala Ile Arg Tyr Pro Pro His Leu 
385                 390                 395                 400 


Asn Pro Gln Asp Pro Leu Lys Asp Leu Val Ser Leu Ala Cys Asp Pro 
                405                 410                 415     


Ala Ser Gln Gln Pro Gly Pro Ser Trp Tyr Leu Gly 
            420                 425             


<210>  147
<211>  1429
<212>  PRT
<213>  Homo sapiens;

<400>  147

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  148
<211>  426
<212>  PRT
<213>  Homo sapiens;

<400>  148

Met Thr Pro Leu Cys Leu Asn Cys Ser Val Leu Pro Gly Asp Leu Tyr 
1               5                   10                  15      


Pro Gly Gly Ala Arg Asn Pro Met Ala Cys Asn Gly Ser Ala Ala Arg 
            20                  25                  30          


Gly His Phe Asp Pro Glu Asp Leu Asn Leu Thr Asp Glu Ala Leu Arg 
        35                  40                  45              


Leu Lys Tyr Leu Gly Pro Gln Gln Thr Glu Leu Phe Met Pro Ile Cys 
    50                  55                  60                  


Ala Thr Tyr Leu Leu Ile Phe Val Val Gly Ala Val Gly Asn Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Val Ile Leu Arg His Lys Ala Met Arg Thr Pro Thr Asn 
                85                  90                  95      


Tyr Tyr Leu Phe Ser Leu Ala Val Ser Asp Leu Leu Val Leu Leu Val 
            100                 105                 110         


Gly Leu Pro Leu Glu Leu Tyr Glu Met Trp His Asn Tyr Pro Phe Leu 
        115                 120                 125             


Leu Gly Val Gly Gly Cys Tyr Phe Arg Thr Leu Leu Phe Glu Met Val 
    130                 135                 140                 


Cys Leu Ala Ser Val Leu Asn Val Thr Ala Leu Ser Val Glu Arg Tyr 
145                 150                 155                 160 


Val Ala Val Val His Pro Leu Gln Ala Arg Ser Met Val Thr Arg Ala 
                165                 170                 175     


His Val Arg Arg Val Leu Gly Ala Val Trp Gly Leu Ala Met Leu Cys 
            180                 185                 190         


Ser Leu Pro Asn Thr Ser Leu His Gly Ile Arg Gln Leu His Val Pro 
        195                 200                 205             


Cys Arg Gly Pro Val Pro Asp Ser Ala Val Cys Met Leu Val Arg Pro 
    210                 215                 220                 


Arg Ala Leu Tyr Asn Met Val Val Gln Thr Thr Ala Leu Leu Phe Phe 
225                 230                 235                 240 


Cys Leu Pro Met Ala Ile Met Ser Val Leu Tyr Leu Leu Ile Gly Leu 
                245                 250                 255     


Arg Leu Arg Arg Glu Arg Leu Leu Leu Met Gln Glu Ala Lys Gly Arg 
            260                 265                 270         


Gly Ser Ala Ala Ala Arg Ser Arg Tyr Thr Cys Arg Leu Gln Gln His 
        275                 280                 285             


Asp Arg Gly Arg Arg Gln Val Thr Lys Met Leu Phe Val Leu Val Val 
    290                 295                 300                 


Val Phe Gly Ile Cys Trp Ala Pro Phe His Ala Asp Arg Val Met Trp 
305                 310                 315                 320 


Ser Val Val Ser Gln Trp Thr Asp Gly Leu His Leu Ala Phe Gln His 
                325                 330                 335     


Val His Val Ile Ser Gly Ile Phe Phe Tyr Leu Gly Ser Ala Ala Asn 
            340                 345                 350         


Pro Val Leu Tyr Ser Leu Met Ser Ser Arg Phe Arg Glu Thr Phe Gln 
        355                 360                 365             


Glu Ala Leu Cys Leu Gly Ala Cys Cys His Arg Leu Arg Pro Arg His 
    370                 375                 380                 


Ser Ser His Ser Leu Ser Arg Met Thr Thr Gly Ser Thr Leu Cys Asp 
385                 390                 395                 400 


Val Gly Ser Leu Gly Ser Trp Val His Pro Leu Ala Gly Asn Asp Gly 
                405                 410                 415     


Pro Glu Ala Gln Gln Glu Thr Asp Pro Ser 
            420                 425     


<210>  149
<211>  357
<212>  PRT
<213>  Homo sapiens;

<400>  149

Met Gln Ser Val Gln Ser Thr Ser Phe Cys Leu Arg Lys Gln Cys Leu 
1               5                   10                  15      


Cys Leu Thr Phe Leu Leu Leu His Leu Leu Gly Gln Val Ala Ala Thr 
            20                  25                  30          


Gln Arg Cys Pro Pro Gln Cys Pro Gly Arg Cys Pro Ala Thr Pro Pro 
        35                  40                  45              


Thr Cys Ala Pro Gly Val Arg Ala Val Leu Asp Gly Cys Ser Cys Cys 
    50                  55                  60                  


Leu Val Cys Ala Arg Gln Arg Gly Glu Ser Cys Ser Asp Leu Glu Pro 
65                  70                  75                  80  


Cys Asp Glu Ser Ser Gly Leu Tyr Cys Asp Arg Ser Ala Asp Pro Ser 
                85                  90                  95      


Asn Gln Thr Gly Ile Cys Thr Ala Val Glu Gly Asp Asn Cys Val Phe 
            100                 105                 110         


Asp Gly Val Ile Tyr Arg Ser Gly Glu Lys Phe Gln Pro Ser Cys Lys 
        115                 120                 125             


Phe Gln Cys Thr Cys Arg Asp Gly Gln Ile Gly Cys Val Pro Arg Cys 
    130                 135                 140                 


Gln Leu Asp Val Leu Leu Pro Glu Pro Asn Cys Pro Ala Pro Arg Lys 
145                 150                 155                 160 


Val Glu Val Pro Gly Glu Cys Cys Glu Lys Trp Ile Cys Gly Pro Asp 
                165                 170                 175     


Glu Glu Asp Ser Leu Gly Gly Leu Thr Leu Ala Ala Tyr Arg Pro Glu 
            180                 185                 190         


Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
        195                 200                 205             


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
    210                 215                 220                 


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
225                 230                 235                 240 


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
                245                 250                 255     


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
            260                 265                 270         


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
        275                 280                 285             


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
    290                 295                 300                 


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
305                 310                 315                 320 


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
                325                 330                 335     


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
            340                 345                 350         


Thr Arg Gly Lys Met 
        355         


<210>  150
<211>  1427
<212>  PRT
<213>  Homo sapiens;

<400>  150

Met Leu Leu Pro Ser Asp Val Ala Arg Leu Val Leu Gly Tyr Leu Gln 
1               5                   10                  15      


Gln Glu Asn Leu Ile Ser Thr Cys Gln Thr Phe Ile Leu Glu Ser Ser 
            20                  25                  30          


Asp Leu Lys Glu Tyr Ala Glu His Cys Thr Asp Glu Gly Phe Ile Pro 
        35                  40                  45              


Ala Cys Leu Leu Ser Leu Phe Gly Lys Asn Leu Thr Thr Ile Leu Asn 
    50                  55                  60                  


Glu Tyr Val Ala Met Lys Thr Lys Glu Thr Ser Asn Asn Val Pro Ala 
65                  70                  75                  80  


Ile Met Ser Ser Leu Trp Lys Lys Leu Asp His Thr Leu Ser Gln Ile 
                85                  90                  95      


Arg Ser Met Gln Ser Ser Pro Arg Phe Ala Gly Ser Gln Arg Ala Arg 
            100                 105                 110         


Thr Arg Thr Gly Ile Ala Glu Ile Lys Arg Gln Arg Lys Leu Ala Ser 
        115                 120                 125             


Gln Thr Ala Pro Ala Ser Ala Glu Leu Leu Thr Leu Pro Tyr Leu Ser 
    130                 135                 140                 


Gly Gln Phe Thr Thr Pro Pro Ser Thr Gly Thr Gln Val Thr Arg Pro 
145                 150                 155                 160 


Ser Gly Gln Ile Ser Asp Pro Ser Arg Ser Tyr Phe Val Val Val Asn 
                165                 170                 175     


His Ser Gln Ser Gln Asp Thr Val Thr Thr Gly Glu Ala Leu Asn Val 
            180                 185                 190         


Ile Pro Gly Ala Gln Glu Lys Lys Ala His Ala Ser Leu Met Ser Pro 
        195                 200                 205             


Gly Arg Arg Lys Ser Glu Ser Gln Arg Lys Ser Thr Thr Leu Ser Gly 
    210                 215                 220                 


Pro His Ser Thr Ile Arg Asn Phe Gln Asp Pro Asn Ala Phe Ala Val 
225                 230                 235                 240 


Glu Lys Gln Met Val Ile Glu Asn Ala Arg Glu Lys Ile Leu Ser Asn 
                245                 250                 255     


Lys Ser Leu Gln Glu Lys Leu Ala Glu Asn Ile Asn Lys Phe Leu Thr 
            260                 265                 270         


Ser Asp Asn Asn Ile Ala Gln Val Pro Lys Gln Thr Asp Asn Asn Pro 
        275                 280                 285             


Thr Glu Pro Glu Thr Ser Ile Asp Glu Phe Leu Gly Leu Pro Ser Glu 
    290                 295                 300                 


Ile His Met Ser Glu Glu Ala Ile Gln Asp Ile Leu Glu Gln Thr Glu 
305                 310                 315                 320 


Ser Asp Pro Ala Phe Gln Ala Leu Phe Asp Leu Phe Asp Tyr Gly Lys 
                325                 330                 335     


Thr Lys Asn Asn Lys Asn Ile Ser Gln Ser Ile Ser Ser Gln Pro Met 
            340                 345                 350         


Glu Ser Asn Pro Ser Ile Val Leu Ala Asp Glu Thr Asn Leu Ala Val 
        355                 360                 365             


Lys Gly Ser Phe Glu Thr Glu Glu Ser Asp Gly Gln Ser Gly Gln Pro 
    370                 375                 380                 


Ala Phe Cys Thr Ser Tyr Gln Asn Asp Asp Pro Leu Asn Ala Leu Lys 
385                 390                 395                 400 


Asn Ser Asn Asn His Asp Val Leu Arg Gln Glu Asp Gln Glu Asn Phe 
                405                 410                 415     


Ser Gln Ile Ser Thr Ser Ile Gln Lys Lys Ala Phe Lys Thr Ala Val 
            420                 425                 430         


Pro Thr Glu Gln Lys Cys Asp Ile Asp Ile Thr Phe Glu Ser Val Pro 
        435                 440                 445             


Asn Leu Asn Asp Phe Asn Gln Arg Gly Asn Ser Asn Ala Glu Cys Asn 
    450                 455                 460                 


Pro His Cys Ala Glu Leu Tyr Thr Asn Gln Met Ser Thr Glu Thr Glu 
465                 470                 475                 480 


Met Ala Ile Gly Ile Glu Lys Asn Ser Leu Ser Ser Asn Val Pro Ser 
                485                 490                 495     


Glu Ser Gln Leu Gln Pro Asp Gln Pro Asp Ile Pro Ile Thr Ser Phe 
            500                 505                 510         


Val Ser Leu Gly Cys Glu Ala Asn Asn Glu Asn Leu Ile Leu Ser Gly 
        515                 520                 525             


Lys Ser Ser Gln Leu Leu Ser Gln Asp Thr Ser Leu Thr Gly Lys Pro 
    530                 535                 540                 


Ser Lys Lys Ser Gln Phe Cys Glu Asn Ser Asn Asp Thr Val Lys Leu 
545                 550                 555                 560 


Lys Ile Asn Phe His Gly Ser Lys Ser Ser Asp Ser Ser Glu Val His 
                565                 570                 575     


Lys Ser Lys Ile Glu Ile Asn Val Leu Glu Pro Val Met Ser Gln Leu 
            580                 585                 590         


Ser Asn Cys Gln Asp Asn Ser Cys Leu Gln Ser Glu Ile Leu Pro Val 
        595                 600                 605             


Ser Val Glu Ser Ser His Leu Asn Val Ser Gly Gln Val Glu Ile His 
    610                 615                 620                 


Leu Gly Asp Ser Leu Ser Ser Thr Lys Gln Pro Ser Asn Asp Ser Ala 
625                 630                 635                 640 


Ser Val Glu Leu Asn His Thr Glu Asn Glu Ala Gln Ala Ser Lys Ser 
                645                 650                 655     


Glu Asn Ser Gln Glu Pro Ser Ser Ser Val Lys Glu Glu Asn Thr Ile 
            660                 665                 670         


Phe Leu Ser Leu Gly Gly Asn Ala Asn Cys Glu Lys Val Ala Leu Thr 
        675                 680                 685             


Pro Pro Glu Gly Thr Pro Val Glu Asn Ser His Ser Leu Pro Pro Glu 
    690                 695                 700                 


Ser Val Cys Ser Ser Val Gly Asp Ser His Pro Glu Ser Gln Asn Thr 
705                 710                 715                 720 


Asp Asp Lys Pro Ser Ser Asn Asn Ser Ala Glu Ile Asp Ala Ser Asn 
                725                 730                 735     


Ile Val Ser Leu Lys Val Ile Ile Ser Asp Asp Pro Phe Val Ser Ser 
            740                 745                 750         


Asp Thr Glu Leu Thr Ser Ala Val Ser Ser Ile Asn Gly Glu Asn Leu 
        755                 760                 765             


Pro Thr Ile Ile Leu Ser Ser Pro Thr Lys Ser Pro Thr Lys Asn Ala 
    770                 775                 780                 


Glu Leu Val Lys Cys Leu Ser Ser Glu Glu Thr Val Gly Ala Val Val 
785                 790                 795                 800 


Tyr Ala Glu Val Gly Asp Ser Ala Ser Met Glu Gln Ser Leu Leu Thr 
                805                 810                 815     


Phe Lys Ser Glu Asp Ser Ala Val Asn Asn Thr Gln Asn Glu Asp Gly 
            820                 825                 830         


Ile Ala Phe Ser Ala Asn Val Thr Pro Cys Val Ser Lys Asp Gly Gly 
        835                 840                 845             


Tyr Ile Gln Leu Met Pro Ala Thr Ser Thr Ala Phe Gly Asn Ser Asn 
    850                 855                 860                 


Asn Ile Leu Ile Ala Thr Cys Val Thr Asp Pro Thr Ala Leu Gly Thr 
865                 870                 875                 880 


Ser Val Ser Gln Ser Asn Val Val Val Leu Pro Gly Asn Ser Ala Pro 
                885                 890                 895     


Met Thr Ala Gln Pro Leu Pro Pro Gln Leu Gln Thr Pro Pro Arg Ser 
            900                 905                 910         


Asn Ser Val Phe Ala Val Asn Gln Ala Val Ser Pro Asn Phe Ser Gln 
        915                 920                 925             


Gly Ser Ala Ile Ile Ile Ala Ser Pro Val Gln Pro Val Leu Gln Gly 
    930                 935                 940                 


Met Val Gly Met Ile Pro Val Ser Val Val Gly Gln Asn Gly Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Pro Pro Arg Gln Val Leu His Met Pro Leu Thr Ala Pro 
                965                 970                 975     


Val Cys Asn Arg Ser Ile Pro Gln Phe Pro Val Pro Pro Lys Ser Gln 
            980                 985                 990         


Lys Ala Gln Gly Leu Arg Asn Lys  Pro Cys Ile Gly Lys  Gln Val Asn 
        995                 1000                 1005             


Asn Leu  Val Asp Ser Ser Gly  His Ser Val Gly Cys  His Ala Gln 
    1010                 1015                 1020             


Lys Thr  Glu Val Ser Asp Lys  Ser Ile Ala Thr Asp  Leu Gly Lys 
    1025                 1030                 1035             


Lys Ser  Glu Glu Thr Thr Val  Pro Phe Pro Glu Glu  Ser Ile Val 
    1040                 1045                 1050             


Pro Ala  Ala Lys Pro Cys His  Arg Arg Val Leu Cys  Phe Asp Ser 
    1055                 1060                 1065             


Thr Thr  Ala Pro Val Ala Asn  Thr Gln Gly Pro Asn  His Lys Met 
    1070                 1075                 1080             


Val Ser  Gln Asn Lys Glu Arg  Asn Ala Val Ser Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Ser  Pro Asn Val Ser Ser  Thr Leu Lys Pro Pro  Ser Asn Asn 
    1100                 1105                 1110             


Ala Ile  Lys Arg Glu Lys Glu  Lys Pro Pro Leu Pro  Lys Ile Leu 
    1115                 1120                 1125             


Ser Lys  Ser Glu Ser Ala Ile  Ser Arg His Thr Thr  Ile Arg Glu 
    1130                 1135                 1140             


Thr Gln  Ser Glu Lys Lys Val  Ser Pro Thr Glu Ile  Val Leu Glu 
    1145                 1150                 1155             


Ser Phe  His Lys Ala Thr Ala  Asn Lys Glu Asn Glu  Leu Cys Ser 
    1160                 1165                 1170             


Asp Val  Glu Arg Gln Lys Asn  Pro Glu Asn Ser Lys  Leu Ser Ile 
    1175                 1180                 1185             


Gly Gln  Gln Asn Gly Gly Leu  Arg Ser Glu Lys Ser  Ile Ala Ser 
    1190                 1195                 1200             


Leu Gln  Glu Met Thr Lys Lys  Gln Gly Thr Ser Ser  Asn Asn Lys 
    1205                 1210                 1215             


Asn Val  Leu Ser Val Gly Thr  Ala Val Lys Asp Leu  Lys Gln Glu 
    1220                 1225                 1230             


Gln Thr  Lys Ser Ala Ser Ser  Leu Ile Thr Thr Glu  Met Leu Gln 
    1235                 1240                 1245             


Asp Ile  Gln Arg His Ser Ser  Val Ser Arg Leu Ala  Asp Ser Ser 
    1250                 1255                 1260             


Asp Leu  Pro Val Pro Arg Thr  Pro Gly Ser Gly Ala  Gly Glu Lys 
    1265                 1270                 1275             


His Lys  Glu Glu Pro Ile Asp  Ile Ile Lys Ala Pro  Ser Ser Arg 
    1280                 1285                 1290             


Arg Phe  Ser Glu Asp Ser Ser  Thr Ser Lys Val Met  Val Pro Pro 
    1295                 1300                 1305             


Val Thr  Pro Asp Leu Pro Ala  Cys Ser Pro Ala Ser  Glu Thr Gly 
    1310                 1315                 1320             


Ser Glu  Asn Ser Val Asn Met  Ala Ala His Thr Leu  Met Ile Leu 
    1325                 1330                 1335             


Ser Arg  Ala Ala Ile Ser Arg  Thr Thr Ser Ala Thr  Pro Leu Lys 
    1340                 1345                 1350             


Asp Asn  Thr Gln Gln Phe Arg  Ala Ser Ser Arg Ser  Thr Thr Lys 
    1355                 1360                 1365             


Lys Arg  Lys Ile Glu Glu Leu  Asp Glu Arg Glu Arg  Asn Ser Arg 
    1370                 1375                 1380             


Pro Ser  Ser Lys Asn Leu Thr  Asn Ser Ser Ile Pro  Met Lys Lys 
    1385                 1390                 1395             


Lys Lys  Ile Lys Lys Lys Lys  Leu Pro Ser Ser Phe  Pro Ala Gly 
    1400                 1405                 1410             


Met Asp  Val Asp Lys Phe Leu  Leu Ser Leu His Tyr  Asp Glu 
    1415                 1420                 1425         


<210>  151
<211>  1288
<212>  PRT
<213>  Homo sapiens;

<400>  151

Met Gly Ser Pro Glu Gly Arg Phe His Phe Ala Ile Asp Arg Gly Gly 
1               5                   10                  15      


Thr Phe Thr Asp Val Phe Ala Gln Cys Pro Gly Gly His Val Arg Val 
            20                  25                  30          


Leu Lys Leu Leu Ser Glu Asp Pro Ala Asn Tyr Ala Asp Ala Pro Thr 
        35                  40                  45              


Glu Gly Ile Arg Arg Ile Leu Glu Gln Glu Ala Gly Met Leu Leu Pro 
    50                  55                  60                  


Arg Asp Gln Pro Leu Asp Ser Ser His Ile Ala Ser Ile Arg Met Gly 
65                  70                  75                  80  


Thr Thr Val Ala Thr Asn Ala Leu Leu Glu Arg Lys Gly Glu Arg Val 
                85                  90                  95      


Ala Leu Leu Val Thr Arg Gly Phe Arg Asp Leu Leu His Ile Gly Thr 
            100                 105                 110         


Gln Ala Arg Gly Asp Leu Phe Asp Leu Ala Val Pro Met Pro Glu Val 
        115                 120                 125             


Leu Tyr Glu Glu Val Leu Glu Val Asp Glu Arg Val Val Leu His Arg 
    130                 135                 140                 


Gly Glu Ala Gly Thr Gly Thr Pro Val Lys Gly Arg Thr Gly Asp Leu 
145                 150                 155                 160 


Leu Glu Val Gln Gln Pro Val Asp Leu Gly Ala Leu Arg Gly Lys Leu 
                165                 170                 175     


Glu Gly Leu Leu Ser Arg Gly Ile Arg Ser Leu Ala Val Val Leu Met 
            180                 185                 190         


His Ser Tyr Thr Trp Ala Gln His Glu Gln Gln Val Gly Val Leu Ala 
        195                 200                 205             


Arg Glu Leu Gly Phe Thr His Val Ser Leu Ser Ser Glu Ala Met Pro 
    210                 215                 220                 


Met Val Arg Ile Val Pro Arg Gly His Thr Ala Cys Ala Asp Ala Tyr 
225                 230                 235                 240 


Leu Thr Pro Ala Ile Gln Arg Tyr Val Gln Gly Phe Cys Arg Gly Phe 
                245                 250                 255     


Gln Gly Gln Leu Lys Asp Val Gln Val Leu Phe Met Arg Ser Asp Gly 
            260                 265                 270         


Gly Leu Ala Pro Met Asp Thr Phe Ser Gly Ser Ser Ala Val Leu Ser 
        275                 280                 285             


Gly Pro Ala Gly Gly Val Val Gly Tyr Ser Ala Thr Thr Tyr Gln Gln 
    290                 295                 300                 


Glu Gly Gly Gln Pro Val Ile Gly Phe Asp Met Gly Gly Thr Ser Thr 
305                 310                 315                 320 


Asp Val Ser Arg Tyr Ala Gly Glu Phe Glu His Val Phe Glu Ala Ser 
                325                 330                 335     


Thr Ala Gly Val Thr Leu Gln Ala Pro Gln Leu Asp Ile Asn Thr Val 
            340                 345                 350         


Ala Ala Gly Gly Gly Ser Arg Leu Phe Phe Arg Ser Gly Leu Phe Val 
        355                 360                 365             


Val Gly Pro Glu Ser Ala Gly Ala His Pro Gly Pro Ala Cys Tyr Arg 
    370                 375                 380                 


Lys Gly Gly Pro Val Thr Val Thr Asp Ala Asn Leu Val Leu Gly Arg 
385                 390                 395                 400 


Leu Leu Pro Ala Ser Phe Pro Cys Ile Phe Gly Pro Gly Glu Asn Gln 
                405                 410                 415     


Pro Leu Ser Pro Glu Ala Ser Arg Lys Ala Leu Glu Ala Val Ala Thr 
            420                 425                 430         


Glu Val Asn Ser Phe Leu Thr Asn Gly Pro Cys Pro Ala Ser Pro Leu 
        435                 440                 445             


Ser Leu Glu Glu Val Ala Met Gly Phe Val Arg Val Ala Asn Glu Ala 
    450                 455                 460                 


Met Cys Arg Pro Ile Arg Ala Leu Thr Gln Ala Arg Gly His Asp Pro 
465                 470                 475                 480 


Ser Ala His Val Leu Ala Cys Phe Gly Gly Ala Gly Gly Gln His Ala 
                485                 490                 495     


Cys Ala Ile Ala Arg Ala Leu Gly Met Asp Thr Val His Ile His Arg 
            500                 505                 510         


His Ser Gly Leu Leu Ser Ala Leu Gly Leu Ala Leu Ala Asp Val Val 
        515                 520                 525             


His Glu Ala Gln Glu Pro Cys Ser Leu Leu Tyr Ala Pro Glu Thr Phe 
    530                 535                 540                 


Val Gln Leu Asp Gln Arg Leu Ser Arg Leu Glu Glu Gln Cys Val Asp 
545                 550                 555                 560 


Ala Leu Gln Ala Gln Gly Phe Pro Arg Ser Gln Ile Ser Thr Glu Ser 
                565                 570                 575     


Phe Leu His Leu Arg Tyr Gln Gly Thr Asp Cys Ala Leu Met Val Ser 
            580                 585                 590         


Ala His Gln His Pro Ala Thr Ala Arg Ser Pro Arg Ala Gly Asp Phe 
        595                 600                 605             


Gly Ala Ala Phe Val Glu Arg Tyr Met Arg Glu Phe Gly Phe Val Ile 
    610                 615                 620                 


Pro Glu Arg Pro Val Val Val Asp Asp Val Arg Val Arg Gly Thr Gly 
625                 630                 635                 640 


Arg Ser Gly Leu Arg Leu Glu Asp Ala Pro Lys Ala Gln Thr Gly Pro 
                645                 650                 655     


Pro Arg Val Asp Lys Met Thr Gln Cys Tyr Phe Glu Gly Gly Tyr Gln 
            660                 665                 670         


Glu Thr Pro Val Tyr Leu Leu Ala Glu Leu Gly Tyr Gly His Lys Leu 
        675                 680                 685             


His Gly Pro Cys Leu Ile Ile Asp Ser Asn Ser Thr Ile Leu Val Glu 
    690                 695                 700                 


Pro Gly Cys Gln Ala Glu Val Thr Lys Thr Gly Asp Ile Cys Ile Ser 
705                 710                 715                 720 


Val Gly Ala Glu Val Pro Gly Thr Val Gly Pro Gln Leu Asp Pro Ile 
                725                 730                 735     


Gln Leu Ser Ile Phe Ser His Arg Phe Met Ser Ile Ala Glu Gln Met 
            740                 745                 750         


Gly Arg Ile Leu Gln Arg Thr Ala Ile Ser Thr Asn Ile Lys Glu Arg 
        755                 760                 765             


Leu Asp Phe Ser Cys Ala Leu Phe Gly Pro Asp Gly Gly Leu Val Ser 
    770                 775                 780                 


Asn Ala Pro His Ile Pro Val His Leu Gly Ala Met Gln Glu Thr Val 
785                 790                 795                 800 


Gln Phe Gln Ile Gln His Leu Gly Ala Asp Leu His Pro Gly Asp Val 
                805                 810                 815     


Leu Leu Ser Asn His Pro Ser Ala Gly Gly Ser His Leu Pro Asp Leu 
            820                 825                 830         


Thr Val Ile Thr Pro Val Phe Trp Pro Gly Gln Thr Arg Pro Val Phe 
        835                 840                 845             


Tyr Val Ala Ser Arg Gly His His Ala Asp Ile Gly Gly Ile Thr Pro 
    850                 855                 860                 


Gly Ser Met Pro Pro His Ser Thr Met Leu Gln Gln Glu Gly Ala Val 
865                 870                 875                 880 


Phe Leu Ser Phe Lys Leu Val Gln Gly Gly Val Phe Gln Glu Glu Ala 
                885                 890                 895     


Val Thr Glu Ala Leu Arg Ala Pro Gly Lys Val Pro Asn Cys Ser Gly 
            900                 905                 910         


Thr Arg Asn Leu His Asp Asn Leu Ser Asp Leu Arg Ala Gln Val Ala 
        915                 920                 925             


Ala Asn Gln Lys Gly Ile Gln Leu Val Gly Glu Leu Ile Gly Gln Tyr 
    930                 935                 940                 


Gly Leu Asp Val Val Gln Ala Tyr Met Gly His Ile Gln Ala Asn Ala 
945                 950                 955                 960 


Glu Leu Ala Val Arg Asp Met Leu Arg Ala Phe Gly Thr Ser Arg Gln 
                965                 970                 975     


Ala Arg Gly Leu Pro Leu Glu Val Ser Ser Glu Asp His Met Asp Asp 
            980                 985                 990         


Gly Ser Pro Ile Arg Leu Arg Val  Gln Ile Ser Leu Ser  Gln Gly Ser 
        995                 1000                 1005             


Ala Val  Phe Asp Phe Ser Gly  Thr Gly Pro Glu Val  Phe Gly Asn 
    1010                 1015                 1020             


Leu Asn  Ala Pro Arg Ala Val  Thr Leu Ser Ala Leu  Ile Tyr Cys 
    1025                 1030                 1035             


Leu Arg  Cys Leu Val Gly Arg  Asp Ile Pro Leu Asn  Gln Gly Cys 
    1040                 1045                 1050             


Leu Ala  Pro Val Arg Val Val  Ile Pro Arg Gly Ser  Ile Leu Asp 
    1055                 1060                 1065             


Pro Ser  Pro Glu Ala Ala Val  Val Gly Gly Asn Val  Leu Thr Ser 
    1070                 1075                 1080             


Gln Arg  Val Val Asp Val Ile  Leu Gly Ala Phe Gly  Ala Cys Ala 
    1085                 1090                 1095             


Ala Ser  Gln Gly Cys Met Asn  Asn Val Thr Leu Gly  Asn Ala His 
    1100                 1105                 1110             


Met Gly  Tyr Tyr Glu Thr Val  Ala Gly Gly Ala Gly  Ala Gly Pro 
    1115                 1120                 1125             


Ser Trp  His Gly Arg Ser Gly  Val His Ser His Met  Thr Asn Thr 
    1130                 1135                 1140             


Arg Ile  Thr Asp Pro Glu Ile  Leu Glu Ser Arg Tyr  Pro Val Ile 
    1145                 1150                 1155             


Leu Arg  Arg Phe Glu Leu Arg  Arg Gly Ser Gly Gly  Arg Gly Arg 
    1160                 1165                 1170             


Phe Arg  Gly Gly Asp Gly Val  Thr Arg Glu Leu Leu  Phe Arg Glu 
    1175                 1180                 1185             


Glu Ala  Leu Leu Ser Val Leu  Thr Glu Arg Arg Ala  Phe Arg Pro 
    1190                 1195                 1200             


Tyr Gly  Leu His Gly Gly Glu  Pro Gly Ala Arg Gly  Leu Asn Leu 
    1205                 1210                 1215             


Leu Ile  Arg Lys Asn Gly Arg  Thr Val Asn Leu Gly  Gly Lys Thr 
    1220                 1225                 1230             


Ser Val  Thr Val Tyr Pro Gly  Asp Val Phe Cys Leu  His Thr Pro 
    1235                 1240                 1245             


Gly Gly  Gly Gly Tyr Gly Asp  Pro Glu Asp Pro Ala  Pro Pro Pro 
    1250                 1255                 1260             


Gly Ser  Pro Pro Gln Ala Leu  Ala Phe Pro Glu His  Gly Ser Val 
    1265                 1270                 1275             


Tyr Glu  Tyr Arg Arg Ala Gln  Glu Ala Val 
    1280                 1285             


<210>  152
<211>  854
<212>  PRT
<213>  Homo sapiens;

<400>  152

Met Gly Met Cys Ser Arg Gln Glu Arg Ile Gln Lys Asp Ile Asp Val 
1               5                   10                  15      


Val Ile Gln Lys Ser Arg Ala Glu Lys Asp Cys Leu Phe Ala Asp Phe 
            20                  25                  30          


Arg Tyr Ser Asp Ser Thr Phe Thr Phe Thr Tyr Val Gly Gly Pro Arg 
        35                  40                  45              


Ser Val Ser Tyr Ser Val His Val Ser Glu Asp Tyr Pro Asp Asn Thr 
    50                  55                  60                  


Tyr Val Ser Ser Ser Glu Asn Asp Glu Asp Val Leu Val Thr Thr Glu 
65                  70                  75                  80  


Pro Ile Pro Val Ile Phe His Arg Ile Ala Thr Glu Leu Arg Lys Thr 
                85                  90                  95      


Asn Asp Ile Asn Cys Cys Leu Ser Ile Lys Ser Lys Leu Gln Lys Glu 
            100                 105                 110         


Asn Gly Glu Glu Ser Arg Gln Asn Ser Thr Val Glu Glu Asp Ser Glu 
        115                 120                 125             


Gly Asp Asn Asp Ser Glu Glu Phe Tyr Tyr Gly Gly Gln Val Asn Tyr 
    130                 135                 140                 


Asp Gly Glu Leu His Lys His Pro Gln Leu Glu Ala Asp Leu Ser Ala 
145                 150                 155                 160 


Val Arg Glu Ile Tyr Gly Pro His Ala Val Ser Leu Arg Glu Tyr Gly 
                165                 170                 175     


Ala Ile Asp Asp Val Asp Ile Asp Leu His Ile Asp Val Ser Phe Leu 
            180                 185                 190         


Asp Glu Glu Ile Ala Val Ala Trp Glu Val Ile Arg Thr Glu Pro Ile 
        195                 200                 205             


Ile Val Arg Leu His Cys Ser Leu Thr Gln Tyr Leu Asn Gly Pro Val 
    210                 215                 220                 


Pro Thr Val Asp Val Phe Gln Ile Ser Thr Lys Glu Arg Phe Gly Leu 
225                 230                 235                 240 


Gly His Gln Leu Lys Lys Ile Met Gln Thr Phe Val Thr Gln Gln Trp 
                245                 250                 255     


Lys Gln Ser Lys Glu Lys Ser Asn Cys Leu His Asn Lys Lys Leu Ser 
            260                 265                 270         


Glu Lys Lys Val Lys Ser Pro Leu His Leu Phe Ser Thr Leu Arg Arg 
        275                 280                 285             


Ser Pro Ser Tyr Pro Pro Pro Gly Cys Gly Lys Ser Lys Ser Lys Leu 
    290                 295                 300                 


Lys Ser Glu Gln Asp Gly Ile Ser Lys Thr His Lys Leu Leu Arg Arg 
305                 310                 315                 320 


Thr Cys Ser Ser Thr Val Lys Thr Asp Asp Val Cys Val Thr Lys Ser 
                325                 330                 335     


His Arg Thr Phe Gly Arg Ser Leu Ser Ser Asp Pro Arg Ala Glu Gln 
            340                 345                 350         


Ala Met Thr Ala Ile Lys Ser His Lys Leu Leu Asn Arg Pro Cys Pro 
        355                 360                 365             


Ala Ala Val Lys Ser Glu Glu Cys Leu Thr Leu Lys Ser His Arg Leu 
    370                 375                 380                 


Leu Thr Arg Ser Cys Ser Gly Asp Pro Arg Cys Glu His Asn Thr Asn 
385                 390                 395                 400 


Leu Lys Pro His Lys Leu Leu Ser Arg Ser Tyr Ser Ser Asn Leu Arg 
                405                 410                 415     


Met Glu Glu Leu Tyr Gly Leu Lys Asn His Lys Leu Leu Ser Lys Ser 
            420                 425                 430         


Tyr Ser Ser Ala Pro Lys Ser Ser Lys Thr Glu Leu Phe Lys Glu Pro 
        435                 440                 445             


Asn Ala Glu Gly Arg Arg Leu Ser Leu Thr Ser Gly Leu Ile Gly Ile 
    450                 455                 460                 


Leu Thr Pro Ser Ser Ser Ser Ser Ser Gln Leu Ala Pro Asn Gly Ala 
465                 470                 475                 480 


Lys Cys Ile Pro Val Arg Asp Arg Gly Phe Leu Val Gln Thr Ile Glu 
                485                 490                 495     


Phe Ala Glu Gln Arg Ile Pro Val Leu Asn Glu Tyr Cys Val Val Cys 
            500                 505                 510         


Asp Glu Pro His Val Phe Gln Asn Gly Pro Met Leu Arg Pro Thr Val 
        515                 520                 525             


Cys Glu Arg Glu Leu Cys Val Phe Ala Phe Gln Thr Leu Gly Val Met 
    530                 535                 540                 


Asn Glu Ala Ala Asp Glu Ile Ala Thr Gly Ala Gln Val Val Asp Leu 
545                 550                 555                 560 


Leu Val Ser Met Cys Arg Ser Ala Leu Glu Ser Pro Arg Lys Val Val 
                565                 570                 575     


Ile Phe Glu Pro Tyr Pro Ser Val Val Asp Pro Asn Asp Pro Gln Met 
            580                 585                 590         


Leu Ala Phe Asn Pro Arg Lys Lys Asn Tyr Asp Arg Val Met Lys Ala 
        595                 600                 605             


Leu Asp Ser Ile Thr Ser Ile Arg Glu Met Thr Gln Ala Pro Tyr Leu 
    610                 615                 620                 


Glu Ile Lys Lys Gln Met Asp Lys Gln Asp Pro Leu Ala His Pro Leu 
625                 630                 635                 640 


Leu Gln Trp Val Ile Ser Ser Asn Arg Ser His Ile Val Lys Leu Pro 
                645                 650                 655     


Val Asn Arg Gln Leu Lys Phe Met His Thr Pro His Gln Phe Leu Leu 
            660                 665                 670         


Leu Ser Ser Pro Pro Ala Lys Glu Ser Asn Phe Arg Ala Ala Lys Lys 
        675                 680                 685             


Leu Phe Gly Ser Thr Phe Ala Phe His Gly Ser His Ile Glu Asn Trp 
    690                 695                 700                 


His Ser Ile Leu Arg Asn Gly Leu Val Val Ala Ser Asn Thr Arg Leu 
705                 710                 715                 720 


Gln Leu His Gly Ala Met Tyr Gly Ser Gly Ile Tyr Leu Ser Pro Met 
                725                 730                 735     


Ser Ser Ile Ser Phe Gly Tyr Ser Gly Met Asn Lys Lys Gln Lys Val 
            740                 745                 750         


Ser Ala Lys Asp Glu Pro Ala Ser Ser Ser Lys Ser Ser Asn Thr Ser 
        755                 760                 765             


Gln Ser Gln Lys Lys Gly Gln Gln Ser Gln Phe Leu Gln Ser Arg Asn 
    770                 775                 780                 


Leu Lys Cys Ile Ala Leu Cys Glu Val Ile Thr Ser Ser Asp Leu His 
785                 790                 795                 800 


Lys His Gly Glu Ile Trp Val Val Pro Asn Thr Asp His Val Cys Thr 
                805                 810                 815     


Arg Phe Phe Phe Val Tyr Glu Asp Gly Gln Val Gly Asp Ala Asn Ile 
            820                 825                 830         


Asn Thr Gln Glu Gly Gly Ile His Lys Glu Ile Leu Arg Val Ile Gly 
        835                 840                 845             


Asn Gln Thr Ala Thr Gly 
    850                 


<210>  153
<211>  415
<212>  PRT
<213>  Homo sapiens;

<400>  153

Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe Thr 
            20                  25                  30          


Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu Gly 
        35                  40                  45              


Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile Thr 
    50                  55                  60                  


Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp Leu 
65                  70                  75                  80  


Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn Gly 
                85                  90                  95      


His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg Pro 
            100                 105                 110         


Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile Ser 
        115                 120                 125             


Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala Ala 
    130                 135                 140                 


Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp Arg 
145                 150                 155                 160 


Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr Pro 
                165                 170                 175     


Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln Leu 
            180                 185                 190         


Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr Cys 
        195                 200                 205             


Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp Ala 
    210                 215                 220                 


Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Pro Ile Val 
225                 230                 235                 240 


Ser Glu Arg Asn Glu Leu Leu Ile Gln Phe Leu Ser Asp Leu Ser Leu 
                245                 250                 255     


Thr Ala Asp Gly Phe Ile Gly His Tyr Ile Phe Arg Pro Lys Lys Leu 
            260                 265                 270         


Pro Thr Thr Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr Thr 
        275                 280                 285             


Gly Leu Lys Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg Thr 
    290                 295                 300                 


Gly Thr Leu Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala Gly 
305                 310                 315                 320 


Thr Val Ile Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr Val 
                325                 330                 335     


Ser Ile Ile Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln Ala 
            340                 345                 350         


Gly Lys Asn Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys Pro 
        355                 360                 365             


Leu Leu Arg Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly Glu 
    370                 375                 380                 


Asp Gly Arg Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe Lys 
385                 390                 395                 400 


Thr Lys Asn Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 
                405                 410                 415 


<210>  154
<211>  345
<212>  PRT
<213>  Homo sapiens;

<400>  154

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 
                245                 250                 255     


Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
            260                 265                 270         


Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 
        275                 280                 285             


His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 
    290                 295                 300                 


Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 
305                 310                 315                 320 


His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 
                325                 330                 335     


Cys Val Cys Arg Gly Ser Thr Gly Gly 
            340                 345 


<210>  155
<211>  1447
<212>  PRT
<213>  Homo sapiens;

<400>  155

Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro 
1               5                   10                  15      


Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val 
            20                  25                  30          


Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp 
        35                  40                  45              


Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val 
65                  70                  75                  80  


Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro 
                85                  90                  95      


Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg 
            100                 105                 110         


Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr 
        115                 120                 125             


Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys 
    130                 135                 140                 


Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr 
145                 150                 155                 160 


Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His 
                165                 170                 175     


Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser 
            180                 185                 190         


Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys 
        195                 200                 205             


Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg 
    210                 215                 220                 


Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val 
225                 230                 235                 240 


Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe 
                245                 250                 255     


Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser 
            260                 265                 270         


Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu 
        275                 280                 285             


Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp 
    290                 295                 300                 


Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly 
305                 310                 315                 320 


Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe 
                325                 330                 335     


Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr 
            340                 345                 350         


Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His 
        355                 360                 365             


Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu 
    370                 375                 380                 


Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr 
                405                 410                 415     


Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln 
            420                 425                 430         


Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser 
        435                 440                 445             


Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val 
    450                 455                 460                 


Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp 
                485                 490                 495     


Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu 
            500                 505                 510         


Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys 
        515                 520                 525             


Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp 
    530                 535                 540                 


Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala 
                565                 570                 575     


Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln 
            580                 585                 590         


Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile 
        595                 600                 605             


Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln 
    610                 615                 620                 


Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val 
625                 630                 635                 640 


Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu 
                645                 650                 655     


Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser 
            660                 665                 670         


Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala 
        675                 680                 685             


Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro 
    690                 695                 700                 


His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys 
705                 710                 715                 720 


Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile 
                725                 730                 735     


Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His 
            740                 745                 750         


Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val 
        755                 760                 765             


Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro 
    770                 775                 780                 


Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn 
785                 790                 795                 800 


Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu 
                805                 810                 815     


Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met 
            820                 825                 830         


Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr 
        835                 840                 845             


Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu 
    850                 855                 860                 


Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu 
865                 870                 875                 880 


Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His 
                885                 890                 895     


Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn 
            900                 905                 910         


Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys 
        915                 920                 925             


Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala 
    930                 935                 940                 


Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln 
945                 950                 955                 960 


Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His 
                965                 970                 975     


Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val 
            980                 985                 990         


Pro Tyr Thr Ile His Leu Leu Ala  His Asp Pro Asp Tyr  Val Lys Val 
        995                 1000                 1005             


Gln Asp  Ile Glu Gln Leu Lys  Asp Val Lys Glu Cys  Leu Trp Phe 
    1010                 1015                 1020             


Val Leu  Glu Ile Leu Met Ala  Lys Asn Glu Asn Asn  Ser His Ala 
    1025                 1030                 1035             


Phe Ile  Arg Lys Met Val Glu  Asn Ile Lys Gln Thr  Lys Asp Ala 
    1040                 1045                 1050             


Gln Gly  Pro Asp Asp Ala Lys  Met Asn Glu Lys Leu  Tyr Thr Val 
    1055                 1060                 1065             


Cys Asp  Val Ala Met Asn Ile  Ile Met Ser Lys Ser  Thr Thr Tyr 
    1070                 1075                 1080             


Ser Leu  Glu Ser Pro Lys Asp  Pro Val Leu Pro Ala  Arg Phe Phe 
    1085                 1090                 1095             


Thr Gln  Pro Asp Lys Asn Phe  Ser Asn Thr Lys Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Pro Glu  Met Lys Ser Phe Phe  Thr Pro Gly Lys Pro  Lys Thr Thr 
    1115                 1120                 1125             


Asn Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ser  Ala Gly Lys 
    1130                 1135                 1140             


Gln Ser  Gln Thr Lys Ser Ser  Arg Met Glu Thr Val  Ser Asn Ala 
    1145                 1150                 1155             


Ser Ser  Ser Ser Asn Pro Ser  Ser Pro Gly Arg Ile  Lys Gly Arg 
    1160                 1165                 1170             


Leu Asp  Ser Ser Glu Met Asp  His Ser Glu Asn Glu  Asp Tyr Thr 
    1175                 1180                 1185             


Met Ser  Ser Pro Leu Pro Gly  Lys Lys Ser Asp Lys  Arg Asp Asp 
    1190                 1195                 1200             


Ser Asp  Leu Val Arg Ser Glu  Leu Glu Lys Pro Arg  Gly Arg Lys 
    1205                 1210                 1215             


Lys Thr  Pro Val Thr Glu Gln  Glu Glu Lys Leu Gly  Met Asp Asp 
    1220                 1225                 1230             


Leu Thr  Lys Leu Val Gln Glu  Gln Lys Pro Lys Gly  Ser Gln Arg 
    1235                 1240                 1245             


Ser Arg  Lys Arg Gly His Thr  Ala Ser Glu Ser Asp  Glu Gln Gln 
    1250                 1255                 1260             


Trp Pro  Glu Glu Lys Arg Leu  Lys Glu Asp Ile Leu  Glu Asn Glu 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ser Pro Pro  Lys Lys Gly Lys Arg  Gly Arg Pro 
    1280                 1285                 1290             


Pro Lys  Pro Leu Gly Gly Gly  Thr Pro Lys Glu Glu  Pro Thr Met 
    1295                 1300                 1305             


Lys Thr  Ser Lys Lys Gly Ser  Lys Lys Lys Ser Gly  Pro Pro Ala 
    1310                 1315                 1320             


Pro Glu  Glu Glu Glu Glu Glu  Glu Arg Gln Ser Gly  Asn Thr Glu 
    1325                 1330                 1335             


Gln Lys  Ser Lys Ser Lys Gln  His Arg Val Ser Arg  Arg Ala Gln 
    1340                 1345                 1350             


Gln Arg  Ala Glu Ser Pro Glu  Ser Ser Ala Ile Glu  Ser Thr Gln 
    1355                 1360                 1365             


Ser Thr  Pro Gln Lys Gly Arg  Gly Arg Pro Ser Lys  Thr Pro Ser 
    1370                 1375                 1380             


Pro Ser  Gln Pro Lys Lys Asn  Val Arg Val Gly Arg  Ser Lys Gln 
    1385                 1390                 1395             


Ala Ala  Thr Lys Glu Asn Asp  Ser Ser Glu Glu Val  Asp Val Phe 
    1400                 1405                 1410             


Gln Gly  Ser Ser Pro Val Asp  Asp Ile Pro Gln Glu  Glu Thr Glu 
    1415                 1420                 1425             


Glu Glu  Glu Val Ser Thr Val  Asn Val Arg Arg Arg  Ser Ala Lys 
    1430                 1435                 1440             


Arg Glu  Arg Arg 
    1445         


<210>  156
<211>  2039
<212>  PRT
<213>  Homo sapiens;

<400>  156

Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 
1               5                   10                  15      


Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 
            20                  25                  30          


Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 
        35                  40                  45              


Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 
    50                  55                  60                  


Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 
65                  70                  75                  80  


Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 
                85                  90                  95      


Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 
            100                 105                 110         


Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 
        115                 120                 125             


Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 
    130                 135                 140                 


Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 
145                 150                 155                 160 


Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 
                165                 170                 175     


Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 
            180                 185                 190         


Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 
        195                 200                 205             


Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 
    210                 215                 220                 


Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 
225                 230                 235                 240 


Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 
                245                 250                 255     


Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 
            260                 265                 270         


Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 
        275                 280                 285             


Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 
    290                 295                 300                 


Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 
305                 310                 315                 320 


Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 
                325                 330                 335     


Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 
            340                 345                 350         


Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 
        355                 360                 365             


Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 
    370                 375                 380                 


Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 
385                 390                 395                 400 


Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 
                405                 410                 415     


Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 
            420                 425                 430         


Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 
        435                 440                 445             


Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 
    450                 455                 460                 


Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 
465                 470                 475                 480 


Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 
                485                 490                 495     


Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 
            500                 505                 510         


Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 
        515                 520                 525             


Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 
    530                 535                 540                 


Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 
545                 550                 555                 560 


Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 
                565                 570                 575     


Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 
            580                 585                 590         


Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 
        595                 600                 605             


Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 
    610                 615                 620                 


Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 
625                 630                 635                 640 


Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 
                645                 650                 655     


Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 
            660                 665                 670         


Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 
        675                 680                 685             


Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 
    690                 695                 700                 


Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 
705                 710                 715                 720 


Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 
                725                 730                 735     


Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 
            740                 745                 750         


Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 
        755                 760                 765             


Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 
    770                 775                 780                 


Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 
785                 790                 795                 800 


Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 
                805                 810                 815     


Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 
            820                 825                 830         


Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 
        835                 840                 845             


Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 
    850                 855                 860                 


Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 
865                 870                 875                 880 


Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 
                885                 890                 895     


Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 
            900                 905                 910         


Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 
        915                 920                 925             


Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 
    930                 935                 940                 


Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 
945                 950                 955                 960 


Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 
                965                 970                 975     


Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 
            980                 985                 990         


Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 
        995                 1000                 1005             


His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 
    1010                 1015                 1020             


Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 
    1025                 1030                 1035             


Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 
    1040                 1045                 1050             


Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 
    1055                 1060                 1065             


Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 
    1070                 1075                 1080             


Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 
    1085                 1090                 1095             


Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 
    1100                 1105                 1110             


Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 
    1115                 1120                 1125             


Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 
    1130                 1135                 1140             


Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 
    1145                 1150                 1155             


Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 
    1160                 1165                 1170             


Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 
    1175                 1180                 1185             


Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 
    1190                 1195                 1200             


Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 
    1205                 1210                 1215             


Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 
    1220                 1225                 1230             


Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 
    1235                 1240                 1245             


Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 
    1250                 1255                 1260             


Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 
    1265                 1270                 1275             


Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 
    1280                 1285                 1290             


Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 
    1295                 1300                 1305             


Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 
    1310                 1315                 1320             


His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 
    1325                 1330                 1335             


Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 
    1340                 1345                 1350             


Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 
    1355                 1360                 1365             


Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 
    1370                 1375                 1380             


Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 
    1385                 1390                 1395             


Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 
    1400                 1405                 1410             


Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 
    1415                 1420                 1425             


Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 
    1430                 1435                 1440             


Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 
    1445                 1450                 1455             


Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 
    1460                 1465                 1470             


Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 
    1475                 1480                 1485             


Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 
    1490                 1495                 1500             


Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 
    1505                 1510                 1515             


Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 
    1535                 1540                 1545             


Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 
    1550                 1555                 1560             


Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 
    1565                 1570                 1575             


Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 
    1580                 1585                 1590             


Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 
    1595                 1600                 1605             


Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 
    1610                 1615                 1620             


Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 
    1625                 1630                 1635             


Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 
    1640                 1645                 1650             


Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 
    1655                 1660                 1665             


Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 
    1670                 1675                 1680             


Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 
    1685                 1690                 1695             


Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 
    1700                 1705                 1710             


Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 
    1715                 1720                 1725             


Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 
    1730                 1735                 1740             


Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 
    1745                 1750                 1755             


Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 
    1760                 1765                 1770             


Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 
    1775                 1780                 1785             


Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 
    1790                 1795                 1800             


Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 
    1805                 1810                 1815             


Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 
    1820                 1825                 1830             


His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 
    1835                 1840                 1845             


Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 
    1850                 1855                 1860             


Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 
    1865                 1870                 1875             


Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 
    1880                 1885                 1890             


Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 
    1895                 1900                 1905             


Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 
    1910                 1915                 1920             


Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 
    1925                 1930                 1935             


Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 
    1940                 1945                 1950             


Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 
    1955                 1960                 1965             


Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 
    1970                 1975                 1980             


Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 
    1985                 1990                 1995             


Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 
    2000                 2005                 2010             


Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 
    2015                 2020                 2025             


Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 
    2030                 2035                 


<210>  157
<211>  1686
<212>  PRT
<213>  Homo sapiens;

<400>  157

Met Ala Gln Ile Ser Ser Asn Ser Gly Phe Lys Glu Cys Pro Ser Ser 
1               5                   10                  15      


His Pro Glu Pro Thr Arg Ala Lys Asp Val Asp Lys Glu Glu Ala Leu 
            20                  25                  30          


Gln Met Glu Ala Glu Ala Leu Ala Lys Leu Gln Lys Asp Arg Gln Val 
        35                  40                  45              


Thr Asp Asn Gln Arg Gly Phe Glu Leu Ser Ser Ser Thr Arg Lys Lys 
    50                  55                  60                  


Ala Gln Val Tyr Asn Lys Gln Asp Tyr Asp Leu Met Val Phe Pro Glu 
65                  70                  75                  80  


Ser Asp Ser Gln Lys Arg Ala Leu Asp Ile Asp Val Glu Lys Leu Thr 
                85                  90                  95      


Gln Ala Glu Leu Glu Lys Leu Leu Leu Asp Asp Ser Phe Glu Thr Lys 
            100                 105                 110         


Lys Thr Pro Val Leu Pro Val Thr Pro Ile Leu Ser Pro Ser Phe Ser 
        115                 120                 125             


Ala Gln Leu Tyr Phe Arg Pro Thr Ile Gln Arg Gly Gln Trp Pro Pro 
    130                 135                 140                 


Gly Leu Pro Gly Pro Ser Thr Tyr Ala Leu Pro Ser Ile Tyr Pro Ser 
145                 150                 155                 160 


Thr Tyr Ser Lys Gln Ala Ala Phe Gln Asn Gly Phe Asn Pro Arg Met 
                165                 170                 175     


Pro Thr Phe Pro Ser Thr Glu Pro Ile Tyr Leu Ser Leu Pro Gly Gln 
            180                 185                 190         


Ser Pro Tyr Phe Ser Tyr Pro Leu Thr Pro Ala Thr Pro Phe His Pro 
        195                 200                 205             


Gln Gly Ser Leu Pro Ile Tyr Arg Pro Val Val Ser Thr Asp Met Ala 
    210                 215                 220                 


Lys Leu Phe Asp Lys Ile Ala Ser Thr Ser Glu Phe Leu Lys Asn Gly 
225                 230                 235                 240 


Lys Ala Arg Thr Asp Leu Glu Ile Thr Asp Ser Lys Val Ser Asn Leu 
                245                 250                 255     


Gln Val Ser Pro Lys Ser Glu Asp Ile Ser Lys Phe Asp Trp Leu Asp 
            260                 265                 270         


Leu Asp Pro Leu Ser Lys Pro Lys Val Asp Asn Val Glu Val Leu Asp 
        275                 280                 285             


His Glu Glu Glu Lys Asn Val Ser Ser Leu Leu Ala Lys Asp Pro Trp 
    290                 295                 300                 


Asp Ala Val Leu Leu Glu Glu Arg Ser Thr Ala Asn Cys His Leu Glu 
305                 310                 315                 320 


Arg Lys Val Asn Gly Lys Ser Leu Ser Val Ala Thr Val Thr Arg Ser 
                325                 330                 335     


Gln Ser Leu Asn Ile Arg Thr Thr Gln Leu Ala Lys Ala Gln Gly His 
            340                 345                 350         


Ile Ser Gln Lys Asp Pro Asn Gly Thr Ser Ser Leu Pro Thr Gly Ser 
        355                 360                 365             


Ser Leu Leu Gln Glu Val Glu Val Gln Asn Glu Glu Met Ala Ala Phe 
    370                 375                 380                 


Cys Arg Ser Ile Thr Lys Leu Lys Thr Lys Phe Pro Tyr Thr Asn His 
385                 390                 395                 400 


Arg Thr Asn Pro Gly Tyr Leu Leu Ser Pro Val Thr Ala Gln Arg Asn 
                405                 410                 415     


Ile Cys Gly Glu Asn Ala Ser Val Lys Val Ser Ile Asp Ile Glu Gly 
            420                 425                 430         


Phe Gln Leu Pro Val Thr Phe Thr Cys Asp Val Ser Ser Thr Val Glu 
        435                 440                 445             


Ile Ile Ile Met Gln Ala Leu Cys Trp Val His Asp Asp Leu Asn Gln 
    450                 455                 460                 


Val Asp Val Gly Ser Tyr Val Leu Lys Val Cys Gly Gln Glu Glu Val 
465                 470                 475                 480 


Leu Gln Asn Asn His Cys Leu Gly Ser His Glu His Ile Gln Asn Cys 
                485                 490                 495     


Arg Lys Trp Asp Thr Glu Ile Arg Leu Gln Leu Leu Thr Phe Ser Ala 
            500                 505                 510         


Met Cys Gln Asn Leu Ala Arg Thr Ala Glu Asp Asp Glu Thr Pro Val 
        515                 520                 525             


Asp Leu Asn Lys His Leu Tyr Gln Ile Glu Lys Pro Cys Lys Glu Ala 
    530                 535                 540                 


Met Thr Arg His Pro Val Glu Glu Leu Leu Asp Ser Tyr His Asn Gln 
545                 550                 555                 560 


Val Glu Leu Ala Leu Gln Ile Glu Asn Gln His Arg Ala Val Asp Gln 
                565                 570                 575     


Val Ile Lys Ala Val Arg Lys Ile Cys Ser Ala Leu Asp Gly Val Glu 
            580                 585                 590         


Thr Leu Ala Ile Thr Glu Ser Val Lys Lys Leu Lys Arg Ala Val Asn 
        595                 600                 605             


Leu Pro Arg Ser Lys Thr Ala Asp Val Thr Ser Leu Phe Gly Gly Glu 
    610                 615                 620                 


Asp Thr Ser Arg Ser Ser Thr Arg Gly Ser Leu Asn Pro Glu Asn Pro 
625                 630                 635                 640 


Val Gln Val Ser Ile Asn Gln Leu Thr Ala Ala Ile Tyr Asp Leu Leu 
                645                 650                 655     


Arg Leu His Ala Asn Ser Gly Arg Ser Pro Thr Asp Cys Ala Gln Ser 
            660                 665                 670         


Ser Lys Ser Val Lys Glu Ala Trp Thr Thr Thr Glu Gln Leu Gln Phe 
        675                 680                 685             


Thr Ile Phe Ala Ala His Gly Ile Ser Ser Asn Trp Val Ser Asn Tyr 
    690                 695                 700                 


Glu Lys Tyr Tyr Leu Ile Cys Ser Leu Ser His Asn Gly Lys Asp Leu 
705                 710                 715                 720 


Phe Lys Pro Ile Gln Ser Lys Lys Val Gly Thr Tyr Lys Asn Phe Phe 
                725                 730                 735     


Tyr Leu Ile Lys Trp Asp Glu Leu Ile Ile Phe Pro Ile Gln Ile Ser 
            740                 745                 750         


Gln Leu Pro Leu Glu Ser Val Leu His Leu Thr Leu Phe Gly Ile Leu 
        755                 760                 765             


Asn Gln Ser Ser Gly Ser Ser Pro Asp Ser Asn Lys Gln Arg Lys Gly 
    770                 775                 780                 


Pro Glu Ala Leu Gly Lys Val Ser Leu Pro Leu Phe Asp Phe Lys Arg 
785                 790                 795                 800 


Phe Leu Thr Cys Gly Thr Lys Leu Leu Tyr Leu Trp Thr Ser Ser His 
                805                 810                 815     


Thr Asn Ser Val Pro Gly Thr Val Thr Lys Lys Gly Tyr Val Met Glu 
            820                 825                 830         


Arg Ile Val Leu Gln Val Asp Phe Pro Ser Pro Ala Phe Asp Ile Ile 
        835                 840                 845             


Tyr Thr Thr Pro Gln Val Asp Arg Ser Ile Ile Gln Gln His Asn Leu 
    850                 855                 860                 


Glu Thr Leu Glu Asn Asp Ile Lys Gly Lys Leu Leu Asp Ile Leu His 
865                 870                 875                 880 


Lys Asp Ser Ser Leu Gly Leu Ser Lys Glu Asp Lys Ala Phe Leu Trp 
                885                 890                 895     


Glu Lys Arg Tyr Tyr Cys Phe Lys His Pro Asn Cys Leu Pro Lys Ile 
            900                 905                 910         


Leu Ala Ser Ala Pro Asn Trp Lys Trp Val Asn Leu Ala Lys Thr Tyr 
        915                 920                 925             


Ser Leu Leu His Gln Trp Pro Ala Leu Tyr Pro Leu Ile Ala Leu Glu 
    930                 935                 940                 


Leu Leu Asp Ser Lys Phe Ala Asp Gln Glu Val Arg Ser Leu Ala Val 
945                 950                 955                 960 


Thr Trp Ile Glu Ala Ile Ser Asp Asp Glu Leu Thr Asp Leu Leu Pro 
                965                 970                 975     


Gln Phe Val Gln Ala Leu Lys Tyr Glu Ile Tyr Leu Asn Ser Ser Leu 
            980                 985                 990         


Val Gln Phe Leu Leu Ser Arg Ala  Leu Gly Asn Ile Gln  Ile Ala His 
        995                 1000                 1005             


Asn Leu  Tyr Trp Leu Leu Lys  Asp Ala Leu His Asp  Val Gln Phe 
    1010                 1015                 1020             


Ser Thr  Arg Tyr Glu His Val  Leu Gly Ala Leu Leu  Ser Val Gly 
    1025                 1030                 1035             


Gly Lys  Arg Leu Arg Glu Glu  Leu Leu Lys Gln Thr  Lys Leu Val 
    1040                 1045                 1050             


Gln Leu  Leu Gly Gly Val Ala  Glu Lys Val Arg Gln  Ala Ser Gly 
    1055                 1060                 1065             


Ser Ala  Arg Gln Val Val Leu  Gln Arg Ser Met Glu  Arg Val Gln 
    1070                 1075                 1080             


Ser Phe  Phe Gln Lys Asn Lys  Cys Arg Leu Pro Leu  Lys Pro Ser 
    1085                 1090                 1095             


Leu Val  Ala Lys Glu Leu Asn  Ile Lys Ser Cys Ser  Phe Phe Ser 
    1100                 1105                 1110             


Ser Asn  Ala Val Pro Leu Lys  Val Thr Met Val Asn  Ala Asp Pro 
    1115                 1120                 1125             


Met Gly  Glu Glu Ile Asn Val  Met Phe Lys Val Gly  Glu Asp Leu 
    1130                 1135                 1140             


Arg Gln  Asp Met Leu Ala Leu  Gln Met Ile Lys Ile  Met Asp Lys 
    1145                 1150                 1155             


Ile Trp  Leu Lys Glu Gly Leu  Asp Leu Arg Met Val  Ile Phe Lys 
    1160                 1165                 1170             


Cys Leu  Ser Thr Gly Arg Asp  Arg Gly Met Val Glu  Leu Val Pro 
    1175                 1180                 1185             


Ala Ser  Asp Thr Leu Arg Lys  Ile Gln Val Glu Tyr  Gly Val Thr 
    1190                 1195                 1200             


Gly Ser  Phe Lys Asp Lys Pro  Leu Ala Glu Trp Leu  Arg Lys Tyr 
    1205                 1210                 1215             


Asn Pro  Ser Glu Glu Glu Tyr  Glu Lys Ala Ser Glu  Asn Phe Ile 
    1220                 1225                 1230             


Tyr Ser  Cys Ala Gly Cys Cys  Val Ala Thr Tyr Val  Leu Gly Ile 
    1235                 1240                 1245             


Cys Asp  Arg His Asn Asp Asn  Ile Met Leu Arg Ser  Thr Gly His 
    1250                 1255                 1260             


Met Phe  His Ile Asp Phe Gly  Lys Phe Leu Gly His  Ala Gln Met 
    1265                 1270                 1275             


Phe Gly  Ser Phe Lys Arg Asp  Arg Ala Pro Phe Val  Leu Thr Ser 
    1280                 1285                 1290             


Asp Met  Ala Tyr Val Ile Asn  Gly Gly Glu Lys Pro  Thr Ile Arg 
    1295                 1300                 1305             


Phe Gln  Leu Phe Val Asp Leu  Cys Cys Gln Ala Tyr  Asn Leu Ile 
    1310                 1315                 1320             


Arg Lys  Gln Thr Asn Leu Phe  Leu Asn Leu Leu Ser  Leu Met Ile 
    1325                 1330                 1335             


Pro Ser  Gly Leu Pro Glu Leu  Thr Ser Ile Gln Asp  Leu Lys Tyr 
    1340                 1345                 1350             


Val Arg  Asp Ala Leu Gln Pro  Gln Thr Thr Asp Ala  Glu Ala Thr 
    1355                 1360                 1365             


Ile Phe  Phe Thr Arg Leu Ile  Glu Ser Ser Leu Gly  Ser Ile Ala 
    1370                 1375                 1380             


Thr Lys  Phe Asn Phe Phe Ile  His Asn Leu Ala Gln  Leu Arg Phe 
    1385                 1390                 1395             


Ser Gly  Leu Pro Ser Asn Asp  Glu Pro Ile Leu Ser  Phe Ser Pro 
    1400                 1405                 1410             


Lys Thr  Tyr Ser Phe Arg Gln  Asp Gly Arg Ile Lys  Glu Val Ser 
    1415                 1420                 1425             


Val Phe  Thr Tyr His Lys Lys  Tyr Asn Pro Asp Lys  His Tyr Ile 
    1430                 1435                 1440             


Tyr Val  Val Arg Ile Leu Arg  Glu Gly Gln Ile Glu  Pro Ser Phe 
    1445                 1450                 1455             


Val Phe  Arg Thr Phe Asp Glu  Phe Gln Glu Leu His  Asn Lys Leu 
    1460                 1465                 1470             


Ser Ile  Ile Phe Pro Leu Trp  Lys Leu Pro Gly Phe  Pro Asn Arg 
    1475                 1480                 1485             


Met Val  Leu Gly Arg Thr His  Ile Lys Asp Val Ala  Ala Lys Arg 
    1490                 1495                 1500             


Lys Ile  Glu Leu Asn Ser Tyr  Leu Gln Ser Leu Met  Asn Ala Ser 
    1505                 1510                 1515             


Thr Asp  Val Ala Glu Cys Asp  Leu Val Cys Thr Phe  Phe His Pro 
    1520                 1525                 1530             


Leu Leu  Arg Asp Glu Lys Ala  Glu Gly Ile Ala Arg  Ser Ala Asp 
    1535                 1540                 1545             


Ala Gly  Ser Phe Ser Pro Thr  Pro Gly Gln Ile Gly  Gly Ala Val 
    1550                 1555                 1560             


Lys Leu  Ser Ile Ser Tyr Arg  Asn Gly Thr Leu Phe  Ile Met Val 
    1565                 1570                 1575             


Met His  Ile Lys Asp Leu Val  Thr Glu Asp Gly Ala  Asp Pro Asn 
    1580                 1585                 1590             


Pro Tyr  Val Lys Thr Tyr Leu  Leu Pro Asp Asn His  Lys Thr Ser 
    1595                 1600                 1605             


Lys Arg  Lys Thr Lys Ile Ser  Arg Lys Thr Arg Asn  Pro Thr Phe 
    1610                 1615                 1620             


Asn Glu  Met Leu Val Tyr Ser  Gly Tyr Ser Lys Glu  Thr Leu Arg 
    1625                 1630                 1635             


Gln Arg  Glu Leu Gln Leu Ser  Val Leu Ser Ala Glu  Ser Leu Arg 
    1640                 1645                 1650             


Glu Asn  Phe Phe Leu Gly Gly  Val Thr Leu Pro Leu  Lys Asp Phe 
    1655                 1660                 1665             


Asn Leu  Ser Lys Glu Thr Val  Lys Trp Tyr Gln Leu  Thr Ala Ala 
    1670                 1675                 1680             


Thr Tyr  Leu 
    1685     


<210>  158
<211>  441
<212>  PRT
<213>  Homo sapiens;

<400>  158

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  159
<211>  1410
<212>  PRT
<213>  Homo sapiens;

<400>  159

Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro 
        275                 280                 285             


Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val 
    290                 295                 300                 


Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro 
                325                 330                 335     


Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser 
            340                 345                 350         


Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp 
        355                 360                 365             


Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe 
    370                 375                 380                 


Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu 
385                 390                 395                 400 


Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser 
                405                 410                 415     


Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val 
            420                 425                 430         


Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr 
        435                 440                 445             


Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys 
    450                 455                 460                 


Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys 
465                 470                 475                 480 


Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys 
                485                 490                 495     


Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His 
            500                 505                 510         


Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly 
        515                 520                 525             


His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln 
    530                 535                 540                 


Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr 
545                 550                 555                 560 


Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu 
                565                 570                 575     


Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys 
            580                 585                 590         


Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His 
        595                 600                 605             


Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys 
    610                 615                 620                 


Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg 
625                 630                 635                 640 


His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe 
                645                 650                 655     


Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His Lys Thr 
            660                 665                 670         


Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val 
        675                 680                 685             


Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser 
    690                 695                 700                 


Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser 
705                 710                 715                 720 


Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser 
                725                 730                 735     


Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg Gln Thr 
            740                 745                 750         


Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro 
        755                 760                 765             


Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg 
    770                 775                 780                 


Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys Ser Pro 
785                 790                 795                 800 


Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala 
                805                 810                 815     


Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys 
            820                 825                 830         


His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg 
        835                 840                 845             


Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg Asp Arg 
    850                 855                 860                 


Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro 
865                 870                 875                 880 


Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu 
                885                 890                 895     


Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala 
            900                 905                 910         


Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala 
        915                 920                 925             


Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp 
    930                 935                 940                 


Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys 
                965                 970                 975     


Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala 
            980                 985                 990         


Ala Glu His Phe Arg Asn Pro Gln  Arg Arg Ile Arg Arg  Trp Leu Arg 
        995                 1000                 1005             


Arg Phe  Gln Ala Ser Gln Gly  Glu Asn Leu Glu Gly  Lys Tyr Leu 
    1010                 1015                 1020             


Ser Phe  Glu Ala Glu Glu Lys  Leu Ala Glu Trp Val  Leu Thr Gln 
    1025                 1030                 1035             


Arg Glu  Gln Gln Leu Pro Val  Asn Glu Glu Thr Leu  Phe Gln Lys 
    1040                 1045                 1050             


Ala Thr  Lys Ile Gly Arg Ser  Leu Glu Gly Gly Phe  Lys Ile Ser 
    1055                 1060                 1065             


Tyr Glu  Trp Ala Val Arg Phe  Met Leu Arg His His  Leu Thr Pro 
    1070                 1075                 1080             


His Ala  Arg Arg Ala Val Ala  His Thr Leu Pro Lys  Asp Val Ala 
    1085                 1090                 1095             


Glu Asn  Ala Gly Leu Phe Ile  Asp Phe Val Gln Arg  Gln Ile His 
    1100                 1105                 1110             


Asn Gln  Asp Leu Pro Leu Ser  Met Ile Val Ala Ile  Asp Glu Ile 
    1115                 1120                 1125             


Ser Leu  Phe Leu Asp Thr Glu  Val Leu Ser Ser Asp  Asp Arg Lys 
    1130                 1135                 1140             


Glu Asn  Ala Leu Gln Thr Val  Gly Thr Gly Glu Pro  Trp Cys Asp 
    1145                 1150                 1155             


Val Val  Leu Ala Ile Leu Ala  Asp Gly Thr Val Leu  Pro Thr Leu 
    1160                 1165                 1170             


Val Phe  Tyr Arg Gly Gln Met  Asp Gln Pro Ala Asn  Met Pro Asp 
    1175                 1180                 1185             


Ser Ile  Leu Leu Glu Ala Lys  Glu Ser Gly Tyr Ser  Asp Asp Glu 
    1190                 1195                 1200             


Ile Met  Glu Leu Trp Ser Thr  Arg Val Trp Gln Lys  His Thr Ala 
    1205                 1210                 1215             


Cys Gln  Arg Ser Lys Gly Met  Leu Val Met Asp Cys  His Arg Thr 
    1220                 1225                 1230             


His Leu  Ser Glu Glu Val Leu  Ala Met Leu Ser Ala  Ser Ser Thr 
    1235                 1240                 1245             


Leu Pro  Ala Val Val Pro Ala  Gly Cys Ser Ser Lys  Ile Gln Pro 
    1250                 1255                 1260             


Leu Asp  Val Cys Ile Lys Arg  Thr Val Lys Asn Phe  Leu His Lys 
    1265                 1270                 1275             


Lys Trp  Lys Glu Gln Ala Arg  Glu Met Ala Asp Thr  Ala Cys Asp 
    1280                 1285                 1290             


Ser Asp  Val Leu Leu Gln Leu  Val Leu Val Trp Leu  Gly Glu Val 
    1295                 1300                 1305             


Leu Gly  Val Ile Gly Asp Cys  Pro Glu Leu Val Gln  Arg Ser Phe 
    1310                 1315                 1320             


Leu Val  Ala Ser Val Leu Pro  Gly Pro Asp Gly Asn  Ile Asn Ser 
    1325                 1330                 1335             


Pro Thr  Arg Asn Ala Asp Met  Gln Glu Glu Leu Ile  Ala Ser Leu 
    1340                 1345                 1350             


Glu Glu  Gln Leu Lys Leu Ser  Gly Glu His Ser Glu  Ser Ser Thr 
    1355                 1360                 1365             


Pro Arg  Pro Arg Ser Ser Pro  Glu Glu Thr Ile Glu  Pro Glu Ser 
    1370                 1375                 1380             


Leu His  Gln Leu Phe Glu Gly  Glu Ser Glu Thr Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Gly Phe  Glu Glu Ala Asp Leu  Asp Leu Met Glu Ile  
    1400                 1405                 1410 


<210>  160
<211>  878
<212>  PRT
<213>  Homo sapiens;

<400>  160

Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly 
1               5                   10                  15      


Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro 
            20                  25                  30          


Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His 
        35                  40                  45              


Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser 
    50                  55                  60                  


Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys 
65                  70                  75                  80  


Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe 
                85                  90                  95      


Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser 
            100                 105                 110         


Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser 
        115                 120                 125             


Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His 
    130                 135                 140                 


Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe 
145                 150                 155                 160 


Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr 
                165                 170                 175     


His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg 
            180                 185                 190         


Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg 
        195                 200                 205             


Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met 
                245                 250                 255     


Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr 
            260                 265                 270         


Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu 
        275                 280                 285             


Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys 
    290                 295                 300                 


Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile 
305                 310                 315                 320 


Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp 
                325                 330                 335     


Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly 
            340                 345                 350         


Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu 
        355                 360                 365             


Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val 
    370                 375                 380                 


Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg 
385                 390                 395                 400 


Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg 
                405                 410                 415     


His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn 
            420                 425                 430         


Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr 
        435                 440                 445             


Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro 
    450                 455                 460                 


His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu 
465                 470                 475                 480 


Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala 
                485                 490                 495     


Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile 
            500                 505                 510         


Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala 
        515                 520                 525             


Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp 
    530                 535                 540                 


Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
545                 550                 555                 560 


Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
                565                 570                 575     


Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
            580                 585                 590         


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro 
        595                 600                 605             


Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe 
    610                 615                 620                 


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
625                 630                 635                 640 


Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr 
                645                 650                 655     


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
            660                 665                 670         


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
        675                 680                 685             


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
    690                 695                 700                 


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
705                 710                 715                 720 


Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
                725                 730                 735     


Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
            740                 745                 750         


Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
        755                 760                 765             


Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile 
    770                 775                 780                 


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
785                 790                 795                 800 


Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu 
                805                 810                 815     


Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser 
            820                 825                 830         


Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly 
        835                 840                 845             


Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln 
    850                 855                 860                 


Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu 
865                 870                 875             


<210>  161
<211>  4128
<212>  PRT
<213>  Homo sapiens;

<400>  161

Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln 
1               5                   10                  15      


Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His 
            20                  25                  30          


Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro 
        35                  40                  45              


Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly 
    50                  55                  60                  


Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu 
65                  70                  75                  80  


Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met 
                85                  90                  95      


Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr 
            100                 105                 110         


Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu 
        115                 120                 125             


Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met 
    130                 135                 140                 


Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu 
145                 150                 155                 160 


Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu 
                165                 170                 175     


Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn 
            180                 185                 190         


Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met 
        195                 200                 205             


Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu 
    210                 215                 220                 


Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu 
225                 230                 235                 240 


Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile 
                245                 250                 255     


Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu 
            260                 265                 270         


Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp 
        275                 280                 285             


Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr 
    290                 295                 300                 


Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu 
305                 310                 315                 320 


Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn 
                325                 330                 335     


Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val 
            340                 345                 350         


Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu 
        355                 360                 365             


Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met 
    370                 375                 380                 


Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr 
385                 390                 395                 400 


Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser 
                405                 410                 415     


Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr 
            420                 425                 430         


Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln 
        435                 440                 445             


Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val 
    450                 455                 460                 


Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser 
465                 470                 475                 480 


Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val 
                485                 490                 495     


Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly 
            500                 505                 510         


Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val 
        515                 520                 525             


Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile 
    530                 535                 540                 


Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu 
545                 550                 555                 560 


Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val 
                565                 570                 575     


Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu 
            580                 585                 590         


Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro 
        595                 600                 605             


Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile 
    610                 615                 620                 


Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu 
625                 630                 635                 640 


Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln 
                645                 650                 655     


Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile 
            660                 665                 670         


Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro 
        675                 680                 685             


Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe 
    690                 695                 700                 


Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln 
705                 710                 715                 720 


Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu 
                725                 730                 735     


Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu 
            740                 745                 750         


Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val 
        755                 760                 765             


Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val 
    770                 775                 780                 


Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu 
785                 790                 795                 800 


Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser 
                805                 810                 815     


Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys 
            820                 825                 830         


His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu 
        835                 840                 845             


Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly 
    850                 855                 860                 


Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met 
865                 870                 875                 880 


Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val 
                885                 890                 895     


Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro 
            900                 905                 910         


Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val 
        915                 920                 925             


Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys 
    930                 935                 940                 


Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln 
945                 950                 955                 960 


Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val 
                965                 970                 975     


Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile 
            980                 985                 990         


His Trp Phe Thr Asn Asn Lys Lys  Phe Glu Ser Gln Asp  Thr Val Ala 
        995                 1000                 1005             


Leu Leu  Glu Ala Ile Leu Asp  Gly Ile Val Asp Pro  Val Asp Ser 
    1010                 1015                 1020             


Thr Leu  Arg Asp Phe Cys Gly  Arg Cys Ile Arg Glu  Phe Leu Lys 
    1025                 1030                 1035             


Trp Ser  Ile Lys Gln Ile Thr  Pro Gln Gln Gln Glu  Lys Ser Pro 
    1040                 1045                 1050             


Val Asn  Thr Lys Ser Leu Phe  Lys Arg Leu Tyr Ser  Leu Ala Leu 
    1055                 1060                 1065             


His Pro  Asn Ala Phe Lys Arg  Leu Gly Ala Ser Leu  Ala Phe Asn 
    1070                 1075                 1080             


Asn Ile  Tyr Arg Glu Phe Arg  Glu Glu Glu Ser Leu  Val Glu Gln 
    1085                 1090                 1095             


Phe Val  Phe Glu Ala Leu Val  Ile Tyr Met Glu Ser  Leu Ala Leu 
    1100                 1105                 1110             


Ala His  Ala Asp Glu Lys Ser  Leu Gly Thr Ile Gln  Gln Cys Cys 
    1115                 1120                 1125             


Asp Ala  Ile Asp His Leu Cys  Arg Ile Ile Glu Lys  Lys His Val 
    1130                 1135                 1140             


Ser Leu  Asn Lys Ala Lys Lys  Arg Arg Leu Pro Arg  Gly Phe Pro 
    1145                 1150                 1155             


Pro Ser  Ala Ser Leu Cys Leu  Leu Asp Leu Val Lys  Trp Leu Leu 
    1160                 1165                 1170             


Ala His  Cys Gly Arg Pro Gln  Thr Glu Cys Arg His  Lys Ser Ile 
    1175                 1180                 1185             


Glu Leu  Phe Tyr Lys Phe Val  Pro Leu Leu Pro Gly  Asn Arg Ser 
    1190                 1195                 1200             


Pro Asn  Leu Trp Leu Lys Asp  Val Leu Lys Glu Glu  Gly Val Ser 
    1205                 1210                 1215             


Phe Leu  Ile Asn Thr Phe Glu  Gly Gly Gly Cys Gly  Gln Pro Ser 
    1220                 1225                 1230             


Gly Ile  Leu Ala Gln Pro Thr  Leu Leu Tyr Leu Arg  Gly Pro Phe 
    1235                 1240                 1245             


Ser Leu  Gln Ala Thr Leu Cys  Trp Leu Asp Leu Leu  Leu Ala Ala 
    1250                 1255                 1260             


Leu Glu  Cys Tyr Asn Thr Phe  Ile Gly Glu Arg Thr  Val Gly Ala 
    1265                 1270                 1275             


Leu Gln  Val Leu Gly Thr Glu  Ala Gln Ser Ser Leu  Leu Lys Ala 
    1280                 1285                 1290             


Val Ala  Phe Phe Leu Glu Ser  Ile Ala Met His Asp  Ile Ile Ala 
    1295                 1300                 1305             


Ala Glu  Lys Cys Phe Gly Thr  Gly Ala Ala Gly Asn  Arg Thr Ser 
    1310                 1315                 1320             


Pro Gln  Glu Gly Glu Arg Tyr  Asn Tyr Ser Lys Cys  Thr Val Val 
    1325                 1330                 1335             


Val Arg  Ile Met Glu Phe Thr  Thr Thr Leu Leu Asn  Thr Ser Pro 
    1340                 1345                 1350             


Glu Gly  Trp Lys Leu Leu Lys  Lys Asp Leu Cys Asn  Thr His Leu 
    1355                 1360                 1365             


Met Arg  Val Leu Val Gln Thr  Leu Cys Glu Pro Ala  Ser Ile Gly 
    1370                 1375                 1380             


Phe Asn  Ile Gly Asp Val Gln  Val Met Ala His Leu  Pro Asp Val 
    1385                 1390                 1395             


Cys Val  Asn Leu Met Lys Ala  Leu Lys Met Ser Pro  Tyr Lys Asp 
    1400                 1405                 1410             


Ile Leu  Glu Thr His Leu Arg  Glu Lys Ile Thr Ala  Gln Ser Ile 
    1415                 1420                 1425             


Glu Glu  Leu Cys Ala Val Asn  Leu Tyr Gly Pro Asp  Ala Gln Val 
    1430                 1435                 1440             


Asp Arg  Ser Arg Leu Ala Ala  Val Val Ser Ala Cys  Lys Gln Leu 
    1445                 1450                 1455             


His Arg  Ala Gly Leu Leu His  Asn Ile Leu Pro Ser  Gln Ser Thr 
    1460                 1465                 1470             


Asp Leu  His His Ser Val Gly  Thr Glu Leu Leu Ser  Leu Val Tyr 
    1475                 1480                 1485             


Lys Gly  Ile Ala Pro Gly Asp  Glu Arg Gln Cys Leu  Pro Ser Leu 
    1490                 1495                 1500             


Asp Leu  Ser Cys Lys Gln Leu  Ala Ser Gly Leu Leu  Glu Leu Ala 
    1505                 1510                 1515             


Phe Ala  Phe Gly Gly Leu Cys  Glu Arg Leu Val Ser  Leu Leu Leu 
    1520                 1525                 1530             


Asn Pro  Ala Val Leu Ser Thr  Ala Ser Leu Gly Ser  Ser Gln Gly 
    1535                 1540                 1545             


Ser Val  Ile His Phe Ser His  Gly Glu Tyr Phe Tyr  Ser Leu Phe 
    1550                 1555                 1560             


Ser Glu  Thr Ile Asn Thr Glu  Leu Leu Lys Asn Leu  Asp Leu Ala 
    1565                 1570                 1575             


Val Leu  Glu Leu Met Gln Ser  Ser Val Asp Asn Thr  Lys Met Val 
    1580                 1585                 1590             


Ser Ala  Val Leu Asn Gly Met  Leu Asp Gln Ser Phe  Arg Glu Arg 
    1595                 1600                 1605             


Ala Asn  Gln Lys His Gln Gly  Leu Lys Leu Ala Thr  Thr Ile Leu 
    1610                 1615                 1620             


Gln His  Trp Lys Lys Cys Asp  Ser Trp Trp Ala Lys  Asp Ser Pro 
    1625                 1630                 1635             


Leu Glu  Thr Lys Met Ala Val  Leu Ala Leu Leu Ala  Lys Ile Leu 
    1640                 1645                 1650             


Gln Ile  Asp Ser Ser Val Ser  Phe Asn Thr Ser His  Gly Ser Phe 
    1655                 1660                 1665             


Pro Glu  Val Phe Thr Thr Tyr  Ile Ser Leu Leu Ala  Asp Thr Lys 
    1670                 1675                 1680             


Leu Asp  Leu His Leu Lys Gly  Gln Ala Val Thr Leu  Leu Pro Phe 
    1685                 1690                 1695             


Phe Thr  Ser Leu Thr Gly Gly  Ser Leu Glu Glu Leu  Arg Arg Val 
    1700                 1705                 1710             


Leu Glu  Gln Leu Ile Val Ala  His Phe Pro Met Gln  Ser Arg Glu 
    1715                 1720                 1725             


Phe Pro  Pro Gly Thr Pro Arg  Phe Asn Asn Tyr Val  Asp Cys Met 
    1730                 1735                 1740             


Lys Lys  Phe Leu Asp Ala Leu  Glu Leu Ser Gln Ser  Pro Met Leu 
    1745                 1750                 1755             


Leu Glu  Leu Met Thr Glu Val  Leu Cys Arg Glu Gln  Gln His Val 
    1760                 1765                 1770             


Met Glu  Glu Leu Phe Gln Ser  Ser Phe Arg Arg Ile  Ala Arg Arg 
    1775                 1780                 1785             


Gly Ser  Cys Val Thr Gln Val  Gly Leu Leu Glu Ser  Val Tyr Glu 
    1790                 1795                 1800             


Met Phe  Arg Lys Asp Asp Pro  Arg Leu Ser Phe Thr  Arg Gln Ser 
    1805                 1810                 1815             


Phe Val  Asp Arg Ser Leu Leu  Thr Leu Leu Trp His  Cys Ser Leu 
    1820                 1825                 1830             


Asp Ala  Leu Arg Glu Phe Phe  Ser Thr Ile Val Val  Asp Ala Ile 
    1835                 1840                 1845             


Asp Val  Leu Lys Ser Arg Phe  Thr Lys Leu Asn Glu  Ser Thr Phe 
    1850                 1855                 1860             


Asp Thr  Gln Ile Thr Lys Lys  Met Gly Tyr Tyr Lys  Ile Leu Asp 
    1865                 1870                 1875             


Val Met  Tyr Ser Arg Leu Pro  Lys Asp Asp Val His  Ala Lys Glu 
    1880                 1885                 1890             


Ser Lys  Ile Asn Gln Val Phe  His Gly Ser Cys Ile  Thr Glu Gly 
    1895                 1900                 1905             


Asn Glu  Leu Thr Lys Thr Leu  Ile Lys Leu Cys Tyr  Asp Ala Phe 
    1910                 1915                 1920             


Thr Glu  Asn Met Ala Gly Glu  Asn Gln Leu Leu Glu  Arg Arg Arg 
    1925                 1930                 1935             


Leu Tyr  His Cys Ala Ala Tyr  Asn Cys Ala Ile Ser  Val Ile Cys 
    1940                 1945                 1950             


Cys Val  Phe Asn Glu Leu Lys  Phe Tyr Gln Gly Phe  Leu Phe Ser 
    1955                 1960                 1965             


Glu Lys  Pro Glu Lys Asn Leu  Leu Ile Phe Glu Asn  Leu Ile Asp 
    1970                 1975                 1980             


Leu Lys  Arg Arg Tyr Asn Phe  Pro Val Glu Val Glu  Val Pro Met 
    1985                 1990                 1995             


Glu Arg  Lys Lys Lys Tyr Ile  Glu Ile Arg Lys Glu  Ala Arg Glu 
    2000                 2005                 2010             


Ala Ala  Asn Gly Asp Ser Asp  Gly Pro Ser Tyr Met  Ser Ser Leu 
    2015                 2020                 2025             


Ser Tyr  Leu Ala Asp Ser Thr  Leu Ser Glu Glu Met  Ser Gln Phe 
    2030                 2035                 2040             


Asp Phe  Ser Thr Gly Val Gln  Ser Tyr Ser Tyr Ser  Ser Gln Asp 
    2045                 2050                 2055             


Pro Arg  Pro Ala Thr Gly Arg  Phe Arg Arg Arg Glu  Gln Arg Asp 
    2060                 2065                 2070             


Pro Thr  Val His Asp Asp Val  Leu Glu Leu Glu Met  Asp Glu Leu 
    2075                 2080                 2085             


Asn Arg  His Glu Cys Met Ala  Pro Leu Thr Ala Leu  Val Lys His 
    2090                 2095                 2100             


Met His  Arg Ser Leu Gly Pro  Pro Gln Gly Glu Glu  Asp Ser Val 
    2105                 2110                 2115             


Pro Arg  Asp Leu Pro Ser Trp  Met Lys Phe Leu His  Gly Lys Leu 
    2120                 2125                 2130             


Gly Asn  Pro Ile Val Pro Leu  Asn Ile Arg Leu Phe  Leu Ala Lys 
    2135                 2140                 2145             


Leu Val  Ile Asn Thr Glu Glu  Val Phe Arg Pro Tyr  Ala Lys His 
    2150                 2155                 2160             


Trp Leu  Ser Pro Leu Leu Gln  Leu Ala Ala Ser Glu  Asn Asn Gly 
    2165                 2170                 2175             


Gly Glu  Gly Ile His Tyr Met  Val Val Glu Ile Val  Ala Thr Ile 
    2180                 2185                 2190             


Leu Ser  Trp Thr Gly Leu Ala  Thr Pro Thr Gly Val  Pro Lys Asp 
    2195                 2200                 2205             


Glu Val  Leu Ala Asn Arg Leu  Leu Asn Phe Leu Met  Lys His Val 
    2210                 2215                 2220             


Phe His  Pro Lys Arg Ala Val  Phe Arg His Asn Leu  Glu Ile Ile 
    2225                 2230                 2235             


Lys Thr  Leu Val Glu Cys Trp  Lys Asp Cys Leu Ser  Ile Pro Tyr 
    2240                 2245                 2250             


Arg Leu  Ile Phe Glu Lys Phe  Ser Gly Lys Asp Pro  Asn Ser Lys 
    2255                 2260                 2265             


Asp Asn  Ser Val Gly Ile Gln  Leu Leu Gly Ile Val  Met Ala Asn 
    2270                 2275                 2280             


Asp Leu  Pro Pro Tyr Asp Pro  Gln Cys Gly Ile Gln  Ser Ser Glu 
    2285                 2290                 2295             


Tyr Phe  Gln Ala Leu Val Asn  Asn Met Ser Phe Val  Arg Tyr Lys 
    2300                 2305                 2310             


Glu Val  Tyr Ala Ala Ala Ala  Glu Val Leu Gly Leu  Ile Leu Arg 
    2315                 2320                 2325             


Tyr Val  Met Glu Arg Lys Asn  Ile Leu Glu Glu Ser  Leu Cys Glu 
    2330                 2335                 2340             


Leu Val  Ala Lys Gln Leu Lys  Gln His Gln Asn Thr  Met Glu Asp 
    2345                 2350                 2355             


Lys Phe  Ile Val Cys Leu Asn  Lys Val Thr Lys Ser  Phe Pro Pro 
    2360                 2365                 2370             


Leu Ala  Asp Arg Phe Met Asn  Ala Val Phe Phe Leu  Leu Pro Lys 
    2375                 2380                 2385             


Phe His  Gly Val Leu Lys Thr  Leu Cys Leu Glu Val  Val Leu Cys 
    2390                 2395                 2400             


Arg Val  Glu Gly Met Thr Glu  Leu Tyr Phe Gln Leu  Lys Ser Lys 
    2405                 2410                 2415             


Asp Phe  Val Gln Val Met Arg  His Arg Asp Asp Glu  Arg Gln Lys 
    2420                 2425                 2430             


Val Cys  Leu Asp Ile Ile Tyr  Lys Met Met Pro Lys  Leu Lys Pro 
    2435                 2440                 2445             


Val Glu  Leu Arg Glu Leu Leu  Asn Pro Val Val Glu  Phe Val Ser 
    2450                 2455                 2460             


His Pro  Ser Thr Thr Cys Arg  Glu Gln Met Tyr Asn  Ile Leu Met 
    2465                 2470                 2475             


Trp Ile  His Asp Asn Tyr Arg  Asp Pro Glu Ser Glu  Thr Asp Asn 
    2480                 2485                 2490             


Asp Ser  Gln Glu Ile Phe Lys  Leu Ala Lys Asp Val  Leu Ile Gln 
    2495                 2500                 2505             


Gly Leu  Ile Asp Glu Asn Pro  Gly Leu Gln Leu Ile  Ile Arg Asn 
    2510                 2515                 2520             


Phe Trp  Ser His Glu Thr Arg  Leu Pro Ser Asn Thr  Leu Asp Arg 
    2525                 2530                 2535             


Leu Leu  Ala Leu Asn Ser Leu  Tyr Ser Pro Lys Ile  Glu Val His 
    2540                 2545                 2550             


Phe Leu  Ser Leu Ala Thr Asn  Phe Leu Leu Glu Met  Thr Ser Met 
    2555                 2560                 2565             


Ser Pro  Asp Tyr Pro Asn Pro  Met Phe Glu His Pro  Leu Ser Glu 
    2570                 2575                 2580             


Cys Glu  Phe Gln Glu Tyr Thr  Ile Asp Ser Asp Trp  Arg Phe Arg 
    2585                 2590                 2595             


Ser Thr  Val Leu Thr Pro Met  Phe Val Glu Thr Gln  Ala Ser Gln 
    2600                 2605                 2610             


Gly Thr  Leu Gln Thr Arg Thr  Gln Glu Gly Ser Leu  Ser Ala Arg 
    2615                 2620                 2625             


Trp Pro  Val Ala Gly Gln Ile  Arg Ala Thr Gln Gln  Gln His Asp 
    2630                 2635                 2640             


Phe Thr  Leu Thr Gln Thr Ala  Asp Gly Arg Ser Ser  Phe Asp Trp 
    2645                 2650                 2655             


Leu Thr  Gly Ser Ser Thr Asp  Pro Leu Val Asp His  Thr Ser Pro 
    2660                 2665                 2670             


Ser Ser  Asp Ser Leu Leu Phe  Ala His Lys Arg Ser  Glu Arg Leu 
    2675                 2680                 2685             


Gln Arg  Ala Pro Leu Lys Ser  Val Gly Pro Asp Phe  Gly Lys Lys 
    2690                 2695                 2700             


Arg Leu  Gly Leu Pro Gly Asp  Glu Val Asp Asn Lys  Val Lys Gly 
    2705                 2710                 2715             


Ala Ala  Gly Arg Thr Asp Leu  Leu Arg Leu Arg Arg  Arg Phe Met 
    2720                 2725                 2730             


Arg Asp  Gln Glu Lys Leu Ser  Leu Met Tyr Ala Arg  Lys Gly Val 
    2735                 2740                 2745             


Ala Glu  Gln Lys Arg Glu Lys  Glu Ile Lys Ser Glu  Leu Lys Met 
    2750                 2755                 2760             


Lys Gln  Asp Ala Gln Val Val  Leu Tyr Arg Ser Tyr  Arg His Gly 
    2765                 2770                 2775             


Asp Leu  Pro Asp Ile Gln Ile  Lys His Ser Ser Leu  Ile Thr Pro 
    2780                 2785                 2790             


Leu Gln  Ala Val Ala Gln Arg  Asp Pro Ile Ile Ala  Lys Gln Leu 
    2795                 2800                 2805             


Phe Ser  Ser Leu Phe Ser Gly  Ile Leu Lys Glu Met  Asp Lys Phe 
    2810                 2815                 2820             


Lys Thr  Leu Ser Glu Lys Asn  Asn Ile Thr Gln Lys  Leu Leu Gln 
    2825                 2830                 2835             


Asp Phe  Asn Arg Phe Leu Asn  Thr Thr Phe Ser Phe  Phe Pro Pro 
    2840                 2845                 2850             


Phe Val  Ser Cys Ile Gln Asp  Ile Ser Cys Gln His  Ala Ala Leu 
    2855                 2860                 2865             


Leu Ser  Leu Asp Pro Ala Ala  Val Ser Ala Gly Cys  Leu Ala Ser 
    2870                 2875                 2880             


Leu Gln  Gln Pro Val Gly Ile  Arg Leu Leu Glu Glu  Ala Leu Leu 
    2885                 2890                 2895             


Arg Leu  Leu Pro Ala Glu Leu  Pro Ala Lys Arg Val  Arg Gly Lys 
    2900                 2905                 2910             


Ala Arg  Leu Pro Pro Asp Val  Leu Arg Trp Val Glu  Leu Ala Lys 
    2915                 2920                 2925             


Leu Tyr  Arg Ser Ile Gly Glu  Tyr Asp Val Leu Arg  Gly Ile Phe 
    2930                 2935                 2940             


Thr Ser  Glu Ile Gly Thr Lys  Gln Ile Thr Gln Ser  Ala Leu Leu 
    2945                 2950                 2955             


Ala Glu  Ala Arg Ser Asp Tyr  Ser Glu Ala Ala Lys  Gln Tyr Asp 
    2960                 2965                 2970             


Glu Ala  Leu Asn Lys Gln Asp  Trp Val Asp Gly Glu  Pro Thr Glu 
    2975                 2980                 2985             


Ala Glu  Lys Asp Phe Trp Glu  Leu Ala Ser Leu Asp  Cys Tyr Asn 
    2990                 2995                 3000             


His Leu  Ala Glu Trp Lys Ser  Leu Glu Tyr Cys Ser  Thr Ala Ser 
    3005                 3010                 3015             


Ile Asp  Ser Glu Asn Pro Pro  Asp Leu Asn Lys Ile  Trp Ser Glu 
    3020                 3025                 3030             


Pro Phe  Tyr Gln Glu Thr Tyr  Leu Pro Tyr Met Ile  Arg Ser Lys 
    3035                 3040                 3045             


Leu Lys  Leu Leu Leu Gln Gly  Glu Ala Asp Gln Ser  Leu Leu Thr 
    3050                 3055                 3060             


Phe Ile  Asp Lys Ala Met His  Gly Glu Leu Gln Lys  Ala Ile Leu 
    3065                 3070                 3075             


Glu Leu  His Tyr Ser Gln Glu  Leu Ser Leu Leu Tyr  Leu Leu Gln 
    3080                 3085                 3090             


Asp Asp  Val Asp Arg Ala Lys  Tyr Tyr Ile Gln Asn  Gly Ile Gln 
    3095                 3100                 3105             


Ser Phe  Met Gln Asn Tyr Ser  Ser Ile Asp Val Leu  Leu His Gln 
    3110                 3115                 3120             


Ser Arg  Leu Thr Lys Leu Gln  Ser Val Gln Ala Leu  Thr Glu Ile 
    3125                 3130                 3135             


Gln Glu  Phe Ile Ser Phe Ile  Ser Lys Gln Gly Asn  Leu Ser Ser 
    3140                 3145                 3150             


Gln Val  Pro Leu Lys Arg Leu  Leu Asn Thr Trp Thr  Asn Arg Tyr 
    3155                 3160                 3165             


Pro Asp  Ala Lys Met Asp Pro  Met Asn Ile Trp Asp  Asp Ile Ile 
    3170                 3175                 3180             


Thr Asn  Arg Cys Phe Phe Leu  Ser Lys Ile Glu Glu  Lys Leu Thr 
    3185                 3190                 3195             


Pro Leu  Pro Glu Asp Asn Ser  Met Asn Val Asp Gln  Asp Gly Asp 
    3200                 3205                 3210             


Pro Ser  Asp Arg Met Glu Val  Gln Glu Gln Glu Glu  Asp Ile Ser 
    3215                 3220                 3225             


Ser Leu  Ile Arg Ser Cys Lys  Phe Ser Met Lys Met  Lys Met Ile 
    3230                 3235                 3240             


Asp Ser  Ala Arg Lys Gln Asn  Asn Phe Ser Leu Ala  Met Lys Leu 
    3245                 3250                 3255             


Leu Lys  Glu Leu His Lys Glu  Ser Lys Thr Arg Asp  Asp Trp Leu 
    3260                 3265                 3270             


Val Ser  Trp Val Gln Ser Tyr  Cys Arg Leu Ser His  Cys Arg Ser 
    3275                 3280                 3285             


Arg Ser  Gln Gly Cys Ser Glu  Gln Val Leu Thr Val  Leu Lys Thr 
    3290                 3295                 3300             


Val Ser  Leu Leu Asp Glu Asn  Asn Val Ser Ser Tyr  Leu Ser Lys 
    3305                 3310                 3315             


Asn Ile  Leu Ala Phe Arg Asp  Gln Asn Ile Leu Leu  Gly Thr Thr 
    3320                 3325                 3330             


Tyr Arg  Ile Ile Ala Asn Ala  Leu Ser Ser Glu Pro  Ala Cys Leu 
    3335                 3340                 3345             


Ala Glu  Ile Glu Glu Asp Lys  Ala Arg Arg Ile Leu  Glu Leu Ser 
    3350                 3355                 3360             


Gly Ser  Ser Ser Glu Asp Ser  Glu Lys Val Ile Ala  Gly Leu Tyr 
    3365                 3370                 3375             


Gln Arg  Ala Phe Gln His Leu  Ser Glu Ala Val Gln  Ala Ala Glu 
    3380                 3385                 3390             


Glu Glu  Ala Gln Pro Pro Ser  Trp Ser Cys Gly Pro  Ala Ala Gly 
    3395                 3400                 3405             


Val Ile  Asp Ala Tyr Met Thr  Leu Ala Asp Phe Cys  Asp Gln Gln 
    3410                 3415                 3420             


Leu Arg  Lys Glu Glu Glu Asn  Ala Ser Val Ile Asp  Ser Ala Glu 
    3425                 3430                 3435             


Leu Gln  Ala Tyr Pro Ala Leu  Val Val Glu Lys Met  Leu Lys Ala 
    3440                 3445                 3450             


Leu Lys  Leu Asn Ser Asn Glu  Ala Arg Leu Lys Phe  Pro Arg Leu 
    3455                 3460                 3465             


Leu Gln  Ile Ile Glu Arg Tyr  Pro Glu Glu Thr Leu  Ser Leu Met 
    3470                 3475                 3480             


Thr Lys  Glu Ile Ser Ser Val  Pro Cys Trp Gln Phe  Ile Ser Trp 
    3485                 3490                 3495             


Ile Ser  His Met Val Ala Leu  Leu Asp Lys Asp Gln  Ala Val Ala 
    3500                 3505                 3510             


Val Gln  His Ser Val Glu Glu  Ile Thr Asp Asn Tyr  Pro Gln Ala 
    3515                 3520                 3525             


Ile Val  Tyr Pro Phe Ile Ile  Ser Ser Glu Ser Tyr  Ser Phe Lys 
    3530                 3535                 3540             


Asp Thr  Ser Thr Gly His Lys  Asn Lys Glu Phe Val  Ala Arg Ile 
    3545                 3550                 3555             


Lys Ser  Lys Leu Asp Gln Gly  Gly Val Ile Gln Asp  Phe Ile Asn 
    3560                 3565                 3570             


Ala Leu  Asp Gln Leu Ser Asn  Pro Glu Leu Leu Phe  Lys Asp Trp 
    3575                 3580                 3585             


Ser Asn  Asp Val Arg Ala Glu  Leu Ala Lys Thr Pro  Val Asn Lys 
    3590                 3595                 3600             


Lys Asn  Ile Glu Lys Met Tyr  Glu Arg Met Tyr Ala  Ala Leu Gly 
    3605                 3610                 3615             


Asp Pro  Lys Ala Pro Gly Leu  Gly Ala Phe Arg Arg  Lys Phe Ile 
    3620                 3625                 3630             


Gln Thr  Phe Gly Lys Glu Phe  Asp Lys His Phe Gly  Lys Gly Gly 
    3635                 3640                 3645             


Ser Lys  Leu Leu Arg Met Lys  Leu Ser Asp Phe Asn  Asp Ile Thr 
    3650                 3655                 3660             


Asn Met  Leu Leu Leu Lys Met  Asn Lys Asp Ser Lys  Pro Pro Gly 
    3665                 3670                 3675             


Asn Leu  Lys Glu Cys Ser Pro  Trp Met Ser Asp Phe  Lys Val Glu 
    3680                 3685                 3690             


Phe Leu  Arg Asn Glu Leu Glu  Ile Pro Gly Gln Tyr  Asp Gly Arg 
    3695                 3700                 3705             


Gly Lys  Pro Leu Pro Glu Tyr  His Val Arg Ile Ala  Gly Phe Asp 
    3710                 3715                 3720             


Glu Arg  Val Thr Val Met Ala  Ser Leu Arg Arg Pro  Lys Arg Ile 
    3725                 3730                 3735             


Ile Ile  Arg Gly His Asp Glu  Arg Glu His Pro Phe  Leu Val Lys 
    3740                 3745                 3750             


Gly Gly  Glu Asp Leu Arg Gln  Asp Gln Arg Val Glu  Gln Leu Phe 
    3755                 3760                 3765             


Gln Val  Met Asn Gly Ile Leu  Ala Gln Asp Ser Ala  Cys Ser Gln 
    3770                 3775                 3780             


Arg Ala  Leu Gln Leu Arg Thr  Tyr Ser Val Val Pro  Met Thr Ser 
    3785                 3790                 3795             


Arg Leu  Gly Leu Ile Glu Trp  Leu Glu Asn Thr Val  Thr Leu Lys 
    3800                 3805                 3810             


Asp Leu  Leu Leu Asn Thr Met  Ser Gln Glu Glu Lys  Ala Ala Tyr 
    3815                 3820                 3825             


Leu Ser  Asp Pro Arg Ala Pro  Pro Cys Glu Tyr Lys  Asp Trp Leu 
    3830                 3835                 3840             


Thr Lys  Met Ser Gly Lys His  Asp Val Gly Ala Tyr  Met Leu Met 
    3845                 3850                 3855             


Tyr Lys  Gly Ala Asn Arg Thr  Glu Thr Val Thr Ser  Phe Arg Lys 
    3860                 3865                 3870             


Arg Glu  Ser Lys Val Pro Ala  Asp Leu Leu Lys Arg  Ala Phe Val 
    3875                 3880                 3885             


Arg Met  Ser Thr Ser Pro Glu  Ala Phe Leu Ala Leu  Arg Ser His 
    3890                 3895                 3900             


Phe Ala  Ser Ser His Ala Leu  Ile Cys Ile Ser His  Trp Ile Leu 
    3905                 3910                 3915             


Gly Ile  Gly Asp Arg His Leu  Asn Asn Phe Met Val  Ala Met Glu 
    3920                 3925                 3930             


Thr Gly  Gly Val Ile Gly Ile  Asp Phe Gly His Ala  Phe Gly Ser 
    3935                 3940                 3945             


Ala Thr  Gln Phe Leu Pro Val  Pro Glu Leu Met Pro  Phe Arg Leu 
    3950                 3955                 3960             


Thr Arg  Gln Phe Ile Asn Leu  Met Leu Pro Met Lys  Glu Thr Gly 
    3965                 3970                 3975             


Leu Met  Tyr Ser Ile Met Val  His Ala Leu Arg Ala  Phe Arg Ser 
    3980                 3985                 3990             


Asp Pro  Gly Leu Leu Thr Asn  Thr Met Asp Val Phe  Val Lys Glu 
    3995                 4000                 4005             


Pro Ser  Phe Asp Trp Lys Asn  Phe Glu Gln Lys Met  Leu Lys Lys 
    4010                 4015                 4020             


Gly Gly  Ser Trp Ile Gln Glu  Ile Asn Val Ala Glu  Lys Asn Trp 
    4025                 4030                 4035             


Tyr Pro  Arg Gln Lys Ile Cys  Tyr Ala Lys Arg Lys  Leu Ala Gly 
    4040                 4045                 4050             


Ala Asn  Pro Ala Val Ile Thr  Cys Asp Glu Leu Leu  Leu Gly His 
    4055                 4060                 4065             


Glu Lys  Ala Pro Ala Phe Arg  Asp Tyr Val Ala Val  Ala Arg Gly 
    4070                 4075                 4080             


Ser Lys  Asp His Asn Ile Arg  Ala Gln Glu Pro Glu  Ser Gly Leu 
    4085                 4090                 4095             


Ser Glu  Glu Thr Gln Val Lys  Cys Leu Met Asp Gln  Ala Thr Asp 
    4100                 4105                 4110             


Pro Asn  Ile Leu Gly Arg Thr  Trp Glu Gly Trp Glu  Pro Trp Met 
    4115                 4120                 4125             


<210>  162
<211>  546
<212>  PRT
<213>  Homo sapiens;

<400>  162

Met Ala Asn Asn Ser Pro Ala Leu Thr Gly Asn Ser Gln Pro Gln His 
1               5                   10                  15      


Gln Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Cys Gly Gly Gly 
            20                  25                  30          


Gly Ala Thr Lys Pro Ala Val Ser Gly Lys Gln Gly Asn Val Leu Pro 
        35                  40                  45              


Leu Trp Gly Asn Glu Lys Thr Met Asn Leu Asn Pro Met Ile Leu Thr 
    50                  55                  60                  


Asn Ile Leu Ser Ser Pro Tyr Phe Lys Val Gln Leu Tyr Glu Leu Lys 
65                  70                  75                  80  


Thr Tyr His Glu Val Val Asp Glu Ile Tyr Phe Lys Val Thr His Val 
                85                  90                  95      


Glu Pro Trp Glu Lys Gly Ser Arg Lys Thr Ala Gly Gln Thr Gly Met 
            100                 105                 110         


Cys Gly Gly Val Arg Gly Val Gly Thr Gly Gly Ile Val Ser Thr Ala 
        115                 120                 125             


Phe Cys Leu Leu Tyr Lys Leu Phe Thr Leu Lys Leu Thr Arg Lys Gln 
    130                 135                 140                 


Val Met Gly Leu Ile Thr His Thr Asp Ser Pro Tyr Ile Arg Ala Leu 
145                 150                 155                 160 


Gly Phe Met Tyr Ile Arg Tyr Thr Gln Pro Pro Thr Asp Leu Trp Asp 
                165                 170                 175     


Trp Phe Glu Ser Phe Leu Asp Asp Glu Glu Asp Leu Asp Val Lys Ala 
            180                 185                 190         


Gly Gly Gly Cys Val Met Thr Ile Gly Glu Met Leu Arg Ser Phe Leu 
        195                 200                 205             


Thr Lys Leu Glu Trp Phe Ser Thr Leu Phe Pro Arg Ile Pro Val Pro 
    210                 215                 220                 


Val Gln Lys Asn Ile Asp Gln Gln Ile Lys Thr Arg Pro Arg Lys Ile 
225                 230                 235                 240 


Lys Lys Asp Gly Lys Glu Gly Ala Glu Glu Ile Asp Arg His Val Glu 
                245                 250                 255     


Arg Arg Arg Ser Arg Ser Pro Arg Arg Ser Leu Ser Pro Arg Arg Ser 
            260                 265                 270         


Pro Arg Arg Ser Arg Ser Arg Ser His His Arg Glu Gly His Gly Ser 
        275                 280                 285             


Ser Ser Phe Asp Arg Glu Leu Glu Arg Glu Lys Glu Arg Gln Arg Leu 
    290                 295                 300                 


Glu Arg Glu Ala Lys Glu Arg Glu Lys Glu Arg Arg Arg Ser Arg Ser 
305                 310                 315                 320 


Ile Asp Arg Gly Leu Glu Arg Arg Arg Ser Arg Ser Arg Glu Arg His 
                325                 330                 335     


Arg Ser Arg Ser Arg Ser Arg Asp Arg Lys Gly Asp Arg Arg Asp Arg 
            340                 345                 350         


Asp Arg Glu Arg Glu Lys Glu Asn Glu Arg Gly Arg Arg Arg Asp Arg 
        355                 360                 365             


Asp Tyr Asp Lys Glu Arg Gly Asn Glu Arg Glu Lys Glu Arg Glu Arg 
    370                 375                 380                 


Ser Arg Glu Arg Ser Lys Glu Gln Arg Ser Arg Gly Glu Val Glu Glu 
385                 390                 395                 400 


Lys Lys His Lys Glu Asp Lys Asp Asp Arg Arg His Arg Asp Asp Lys 
                405                 410                 415     


Arg Asp Ser Lys Lys Glu Lys Lys His Ser Arg Ser Arg Ser Arg Glu 
            420                 425                 430         


Arg Lys His Arg Ser Arg Ser Arg Ser Arg Asn Ala Gly Lys Arg Ser 
        435                 440                 445             


Arg Ser Arg Ser Lys Glu Lys Ser Ser Lys His Lys Asn Glu Ser Lys 
    450                 455                 460                 


Glu Lys Ser Asn Lys Arg Ser Arg Ser Gly Ser Gln Gly Arg Thr Asp 
465                 470                 475                 480 


Ser Val Glu Lys Ser Lys Lys Arg Glu His Ser Pro Ser Lys Glu Lys 
                485                 490                 495     


Ser Arg Lys Arg Ser Arg Ser Lys Glu Arg Ser His Lys Arg Asp His 
            500                 505                 510         


Ser Asp Ser Lys Asp Gln Ser Asp Lys His Asp Arg Arg Arg Ser Gln 
        515                 520                 525             


Ser Ile Glu Gln Glu Ser Gln Glu Lys Gln His Lys Asn Lys Asp Glu 
    530                 535                 540                 


Thr Val 
545     


<210>  163
<211>  383
<212>  PRT
<213>  Homo sapiens;

<400>  163

Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys 
1               5                   10                  15      


Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp 
            20                  25                  30          


Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu 
        35                  40                  45              


Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser 
    50                  55                  60                  


Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu 
65                  70                  75                  80  


Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg 
                85                  90                  95      


Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly 
            100                 105                 110         


Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg 
        115                 120                 125             


Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe 
    130                 135                 140                 


Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys 
145                 150                 155                 160 


Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys 
                165                 170                 175     


Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val 
            180                 185                 190         


Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp 
        195                 200                 205             


Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val 
    210                 215                 220                 


Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp 
225                 230                 235                 240 


Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His 
                245                 250                 255     


Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu 
            260                 265                 270         


Pro Gly Gly Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly 
        275                 280                 285             


Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu 
    290                 295                 300                 


Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val 
305                 310                 315                 320 


Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile 
                325                 330                 335     


Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro 
            340                 345                 350         


Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln 
        355                 360                 365             


Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly 
    370                 375                 380             


<210>  164
<211>  492
<212>  PRT
<213>  Homo sapiens;

<400>  164

Met Ala Asn Asn Tyr Lys Lys Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Ile Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Pro Lys Met Lys Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Pro Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Glu Phe Phe Lys Glu Ile Pro Thr Leu Gly Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Arg Glu Lys Leu Lys Val Ala Asn Lys Ile Glu Ser Ile 
                85                  90                  95      


Pro Val Lys Gly Ile Ile Pro Ser Lys Lys Thr Lys Gln Lys Glu Val 
            100                 105                 110         


Tyr Pro Ala Thr Pro Ala Cys Thr Pro Ser Asn Arg Leu Thr Ala Lys 
        115                 120                 125             


Gly Ala Glu Glu Thr Leu Gly Pro Gln Lys Arg Lys Lys Pro Ser Glu 
    130                 135                 140                 


Glu Glu Thr Gly Thr Lys Arg Ser Lys Met Ser Lys Glu Gln Thr Arg 
145                 150                 155                 160 


Pro Ser Cys Ser Ala Gly Ala Ser Thr Ser Thr Ala Met Gly Arg Ser 
                165                 170                 175     


Pro Pro Pro Gln Thr Ser Ser Ser Ala Pro Pro Asn Thr Ser Ser Thr 
            180                 185                 190         


Glu Ser Leu Lys Pro Leu Ala Asn Arg His Ala Thr Ala Ser Lys Asn 
        195                 200                 205             


Ile Phe Arg Glu Asp Pro Ile Ile Ala Met Val Leu Asn Ala Thr Lys 
    210                 215                 220                 


Val Phe Lys Tyr Glu Ser Ser Glu Asn Glu Gln Arg Arg Met Phe His 
225                 230                 235                 240 


Ala Thr Val Ala Thr Gln Thr Gln Phe Phe His Val Lys Val Leu Asn 
                245                 250                 255     


Ile Asn Leu Lys Arg Lys Phe Ile Lys Lys Arg Ile Ile Ile Ile Ser 
            260                 265                 270         


Asn Tyr Ser Lys Arg Asn Ser Leu Leu Glu Val Asn Glu Ala Ser Ser 
        275                 280                 285             


Val Ser Glu Ala Gly Pro Asp Gln Thr Phe Glu Val Pro Lys Asp Ile 
    290                 295                 300                 


Ile Arg Arg Ala Lys Lys Ile Pro Lys Ile Asn Ile Leu His Lys Gln 
305                 310                 315                 320 


Thr Ser Gly Tyr Ile Val Tyr Gly Leu Phe Met Leu His Thr Lys Ile 
                325                 330                 335     


Val Asn Arg Lys Thr Thr Ile Tyr Glu Ile Gln Asp Lys Thr Gly Ser 
            340                 345                 350         


Met Ala Val Val Gly Lys Gly Glu Cys His Asn Ile Pro Cys Glu Lys 
        355                 360                 365             


Gly Asp Lys Leu Arg Leu Phe Cys Phe Arg Leu Arg Lys Arg Glu Asn 
    370                 375                 380                 


Met Ser Lys Leu Met Ser Glu Met His Ser Phe Ile Gln Ile Gln Lys 
385                 390                 395                 400 


Asn Thr Asn Gln Arg Ser His Asp Ser Arg Ser Met Ala Leu Pro Gln 
                405                 410                 415     


Glu Gln Ser Gln His Pro Lys Pro Ser Glu Ala Ser Thr Thr Leu Pro 
            420                 425                 430         


Glu Ser His Leu Lys Thr Pro Gln Met Pro Pro Thr Thr Pro Ser Ser 
        435                 440                 445             


Ser Ser Phe Thr Lys Lys Asp Glu Thr His Pro Gly Ala Gln Ser Ser 
    450                 455                 460                 


Pro Ala Asn Phe Arg Ile Thr Ser Pro Thr Val Ala Pro Pro Leu Ser 
465                 470                 475                 480 


Ser Asp Thr Ser Thr Asn Arg His Pro Ala Val Pro 
                485                 490         


<210>  165
<211>  776
<212>  PRT
<213>  Homo sapiens;

<400>  165

Met Asn Asn Ser Leu Glu Asn Thr Ile Ser Phe Glu Glu Tyr Ile Arg 
1               5                   10                  15      


Val Lys Ala Arg Ser Val Pro Gln His Arg Met Lys Glu Phe Leu Asp 
            20                  25                  30          


Ser Leu Ala Ser Lys Gly Pro Glu Ala Leu Gln Glu Phe Gln Gln Thr 
        35                  40                  45              


Ala Thr Thr Thr Met Val Tyr Gln Gln Gly Gly Asn Cys Ile Tyr Thr 
    50                  55                  60                  


Asp Ser Thr Glu Val Ala Gly Ser Leu Leu Glu Leu Ala Cys Pro Val 
65                  70                  75                  80  


Thr Thr Ser Val Gln Pro Gln Thr Gln Gln Glu Gln Gln Ile Gln Val 
                85                  90                  95      


Gln Gln Pro Gln Gln Val Gln Val Gln Val Gln Val Gln Gln Ser Pro 
            100                 105                 110         


Gln Gln Val Ser Ala Gln Leu Ser Pro Gln Leu Thr Val His Gln Pro 
        115                 120                 125             


Thr Glu Gln Pro Ile Gln Val Gln Val Gln Ile Gln Gly Gln Ala Pro 
    130                 135                 140                 


Gln Ser Ala Ala Pro Ser Ile Gln Thr Pro Ser Leu Gln Ser Pro Ser 
145                 150                 155                 160 


Pro Ser Gln Leu Gln Ala Ala Gln Ile Gln Val Gln His Val Gln Ala 
                165                 170                 175     


Ala Gln Gln Ile Gln Ala Ala Glu Ile Pro Glu Glu His Ile Pro His 
            180                 185                 190         


Gln Gln Ile Gln Ala Gln Leu Val Ala Gly Gln Ser Leu Ala Gly Gly 
        195                 200                 205             


Gln Gln Ile Gln Ile Gln Thr Val Gly Ala Leu Ser Pro Pro Pro Ser 
    210                 215                 220                 


Gln Gln Gly Ser Pro Arg Glu Gly Glu Arg Arg Val Gly Thr Ala Ser 
225                 230                 235                 240 


Val Leu Gln Pro Val Lys Lys Arg Lys Val Asp Met Pro Ile Thr Val 
                245                 250                 255     


Ser Tyr Ala Ile Ser Gly Gln Pro Val Ala Thr Val Leu Ala Ile Pro 
            260                 265                 270         


Gln Gly Gln Gln Gln Ser Tyr Val Ser Leu Arg Pro Asp Leu Leu Thr 
        275                 280                 285             


Val Asp Ser Ala His Leu Tyr Ser Ala Thr Gly Thr Ile Thr Ser Pro 
    290                 295                 300                 


Thr Gly Glu Thr Trp Thr Ile Pro Val Tyr Ser Ala Gln Pro Arg Gly 
305                 310                 315                 320 


Asp Pro Gln Gln Gln Ser Ile Thr His Ile Ala Ile Pro Gln Glu Ala 
                325                 330                 335     


Tyr Asn Ala Val His Val Ser Gly Ser Pro Thr Ala Leu Ala Ala Val 
            340                 345                 350         


Lys Leu Glu Asp Asp Lys Glu Lys Met Val Gly Thr Thr Ser Val Val 
        355                 360                 365             


Lys Asn Ser His Glu Glu Val Val Gln Thr Leu Ala Asn Ser Leu Phe 
    370                 375                 380                 


Pro Ala Gln Phe Met Asn Gly Asn Ile His Ile Pro Val Ala Val Gln 
385                 390                 395                 400 


Ala Val Ala Gly Thr Tyr Gln Asn Thr Ala Gln Thr Val His Ile Trp 
                405                 410                 415     


Asp Pro Gln Gln Gln Pro Gln Gln Gln Thr Pro Gln Glu Gln Thr Pro 
            420                 425                 430         


Pro Pro Gln Gln Gln Gln Gln Gln Leu Gln Val Thr Cys Ser Ala Gln 
        435                 440                 445             


Thr Val Gln Val Ala Glu Val Glu Pro Gln Ser Gln Pro Gln Pro Ser 
    450                 455                 460                 


Pro Glu Leu Leu Leu Pro Asn Ser Leu Lys Pro Glu Glu Gly Leu Glu 
465                 470                 475                 480 


Val Trp Lys Asn Trp Ala Gln Thr Lys Asn Ala Glu Leu Glu Lys Asp 
                485                 490                 495     


Ala Gln Asn Arg Leu Ala Pro Ile Gly Arg Arg Gln Leu Leu Arg Phe 
            500                 505                 510         


Gln Glu Asp Leu Ile Ser Ser Ala Val Ala Glu Leu Asn Tyr Gly Leu 
        515                 520                 525             


Cys Leu Met Thr Arg Glu Ala Arg Asn Gly Glu Gly Glu Pro Tyr Asp 
    530                 535                 540                 


Pro Asp Val Leu Tyr Tyr Ile Phe Leu Cys Ile Gln Lys Tyr Leu Phe 
545                 550                 555                 560 


Glu Asn Gly Arg Val Asp Asp Ile Phe Ser Asp Leu Tyr Tyr Val Arg 
                565                 570                 575     


Phe Thr Glu Trp Leu His Glu Val Leu Lys Asp Val Gln Pro Arg Val 
            580                 585                 590         


Thr Pro Leu Gly Tyr Val Leu Pro Ser His Val Thr Glu Glu Met Leu 
        595                 600                 605             


Trp Glu Cys Lys Gln Leu Gly Ala His Ser Pro Ser Thr Leu Leu Thr 
    610                 615                 620                 


Thr Leu Met Phe Phe Asn Thr Lys Tyr Phe Leu Leu Lys Thr Val Asp 
625                 630                 635                 640 


Gln His Met Lys Leu Ala Phe Ser Lys Val Leu Arg Gln Thr Lys Lys 
                645                 650                 655     


Asn Pro Ser Asn Pro Lys Asp Lys Ser Thr Ser Ile Arg Tyr Leu Lys 
            660                 665                 670         


Ala Leu Gly Ile His Gln Thr Gly Gln Lys Val Thr Asp Asp Met Tyr 
        675                 680                 685             


Ala Glu Gln Thr Glu Asn Pro Glu Asn Pro Leu Arg Cys Pro Ile Lys 
    690                 695                 700                 


Leu Tyr Asp Phe Tyr Leu Phe Lys Cys Pro Gln Ser Val Lys Gly Arg 
705                 710                 715                 720 


Asn Asp Thr Phe Tyr Leu Thr Pro Glu Pro Val Val Ala Pro Asn Ser 
                725                 730                 735     


Pro Ile Trp Tyr Ser Val Gln Pro Ile Ser Arg Glu Gln Met Gly Gln 
            740                 745                 750         


Met Leu Thr Arg Ile Leu Val Ile Arg Glu Ile Gln Glu Ala Ile Ala 
        755                 760                 765             


Val Ala Asn Ala Ser Thr Met His 
    770                 775     


<210>  166
<211>  225
<212>  PRT
<213>  Homo sapiens;

<400>  166

Met Ala Gly Gly Gly Ala Gly Asp Pro Gly Leu Gly Ala Ala Ala Ala 
1               5                   10                  15      


Pro Ala Pro Glu Thr Arg Glu His Leu Phe Lys Val Leu Val Ile Gly 
            20                  25                  30          


Glu Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
        35                  40                  45              


Leu Phe Ser Gln His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
    50                  55                  60                  


Lys Val Leu Asn Trp Asp Ser Arg Thr Leu Val Arg Leu Gln Leu Trp 
65                  70                  75                  80  


Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
                85                  90                  95      


Lys Glu Ala Val Gly Ala Phe Val Val Phe Asp Ile Ser Arg Ser Ser 
            100                 105                 110         


Thr Phe Glu Ala Val Leu Lys Trp Lys Ser Asp Leu Asp Ser Lys Val 
        115                 120                 125             


His Leu Pro Asn Gly Ser Pro Ile Pro Ala Val Leu Leu Ala Asn Lys 
    130                 135                 140                 


Cys Asp Gln Asn Lys Asp Ser Ser Gln Ser Pro Ser Gln Val Asp Gln 
145                 150                 155                 160 


Phe Cys Lys Glu His Gly Phe Ala Gly Trp Phe Glu Thr Ser Ala Lys 
                165                 170                 175     


Asp Asn Ile Asn Ile Glu Glu Ala Ala Arg Phe Leu Val Glu Lys Ile 
            180                 185                 190         


Leu Val Asn His Gln Ser Phe Pro Asn Glu Glu Asn Asp Val Asp Lys 
        195                 200                 205             


Ile Lys Leu Asp Gln Glu Thr Leu Arg Ala Glu Asn Lys Ser Gln Cys 
    210                 215                 220                 


Cys 
225 


<210>  167
<211>  977
<212>  PRT
<213>  Homo sapiens;

<400>  167

Met Arg Thr Ala Gly Arg Asp Pro Val Pro Arg Arg Ser Pro Arg Trp 
1               5                   10                  15      


Arg Arg Ala Val Pro Leu Cys Glu Thr Ser Ala Gly Arg Arg Val Thr 
            20                  25                  30          


Gln Leu Arg Gly Asp Asp Leu Arg Arg Pro Ala Thr Met Lys Gly Lys 
        35                  40                  45              


Glu Arg Ser Pro Val Lys Ala Lys Arg Ser Arg Gly Gly Glu Asp Ser 
    50                  55                  60                  


Thr Ser Arg Gly Glu Arg Ser Lys Lys Leu Gly Gly Ser Gly Gly Ser 
65                  70                  75                  80  


Asn Gly Ser Ser Ser Gly Lys Thr Asp Ser Gly Gly Gly Ser Arg Arg 
                85                  90                  95      


Ser Leu His Leu Asp Lys Ser Ser Ser Arg Gly Gly Ser Arg Glu Tyr 
            100                 105                 110         


Asp Thr Gly Gly Gly Ser Ser Ser Ser Arg Leu His Ser Tyr Ser Ser 
        115                 120                 125             


Pro Ser Thr Lys Asn Ser Ser Gly Gly Gly Glu Ser Arg Ser Ser Ser 
    130                 135                 140                 


Arg Gly Gly Gly Gly Glu Ser Arg Ser Ser Gly Ala Ala Ser Ser Ala 
145                 150                 155                 160 


Pro Gly Gly Gly Asp Gly Ala Glu Tyr Lys Thr Leu Lys Ile Ser Glu 
                165                 170                 175     


Leu Gly Ser Gln Leu Ser Asp Glu Ala Val Glu Asp Gly Leu Phe His 
            180                 185                 190         


Glu Phe Lys Arg Phe Gly Asp Val Ser Val Lys Ile Ser His Leu Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Asp Glu Arg Val Ala Phe Val Asn Phe Arg Arg 
    210                 215                 220                 


Pro Glu Asp Ala Arg Ala Ala Lys His Ala Arg Gly Arg Leu Val Leu 
225                 230                 235                 240 


Tyr Asp Arg Pro Leu Lys Ile Glu Ala Val Tyr Val Ser Arg Arg Arg 
                245                 250                 255     


Ser Arg Ser Pro Leu Asp Lys Asp Thr Tyr Pro Pro Ser Ala Ser Val 
            260                 265                 270         


Val Gly Ala Ser Val Gly Gly His Arg His Pro Pro Gly Gly Gly Gly 
        275                 280                 285             


Gly Gln Arg Ser Leu Ser Pro Gly Gly Ala Ala Leu Gly Tyr Arg Asp 
    290                 295                 300                 


Tyr Arg Leu Gln Gln Leu Ala Leu Gly Arg Leu Pro Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Pro Leu Pro Arg Asp Leu Glu Arg Glu Arg Asp Tyr Pro Phe Tyr 
                325                 330                 335     


Glu Arg Val Arg Pro Ala Tyr Ser Leu Glu Pro Arg Val Gly Ala Gly 
            340                 345                 350         


Ala Gly Ala Ala Pro Phe Arg Glu Val Asp Glu Ile Ser Pro Glu Asp 
        355                 360                 365             


Asp Gln Arg Ala Asn Arg Thr Leu Phe Leu Gly Asn Leu Asp Ile Thr 
    370                 375                 380                 


Val Thr Glu Ser Asp Leu Arg Arg Ala Phe Asp Arg Phe Gly Val Ile 
385                 390                 395                 400 


Thr Glu Val Asp Ile Lys Arg Pro Ser Arg Gly Gln Thr Ser Thr Tyr 
                405                 410                 415     


Gly Phe Leu Lys Phe Glu Asn Leu Asp Met Ser His Arg Ala Lys Leu 
            420                 425                 430         


Ala Met Ser Gly Lys Ile Ile Ile Arg Asn Pro Ile Lys Ile Gly Tyr 
        435                 440                 445             


Gly Lys Ala Thr Pro Thr Thr Arg Leu Trp Val Gly Gly Leu Gly Pro 
    450                 455                 460                 


Trp Val Pro Leu Ala Ala Leu Ala Arg Glu Phe Asp Arg Phe Gly Thr 
465                 470                 475                 480 


Ile Arg Thr Ile Asp Tyr Arg Lys Gly Asp Ser Trp Ala Tyr Ile Gln 
                485                 490                 495     


Tyr Glu Ser Leu Asp Ala Ala His Ala Ala Trp Thr His Met Arg Gly 
            500                 505                 510         


Phe Pro Leu Gly Gly Pro Asp Arg Arg Leu Arg Val Asp Phe Ala Asp 
        515                 520                 525             


Thr Glu His Arg Tyr Gln Gln Gln Tyr Leu Gln Pro Leu Pro Leu Thr 
    530                 535                 540                 


His Tyr Glu Leu Val Thr Asp Ala Phe Gly His Arg Ala Pro Asp Pro 
545                 550                 555                 560 


Leu Arg Gly Ala Arg Asp Arg Thr Pro Pro Leu Leu Tyr Arg Asp Arg 
                565                 570                 575     


Asp Arg Asp Leu Tyr Pro Asp Ser Asp Trp Val Pro Pro Pro Pro Pro 
            580                 585                 590         


Val Arg Glu Arg Ser Thr Arg Thr Ala Ala Thr Ser Val Pro Ala Tyr 
        595                 600                 605             


Glu Pro Leu Asp Ser Leu Asp Arg Arg Arg Asp Gly Trp Ser Leu Asp 
    610                 615                 620                 


Arg Asp Arg Gly Asp Arg Asp Leu Pro Ser Ser Arg Asp Gln Pro Arg 
625                 630                 635                 640 


Lys Arg Arg Leu Pro Glu Glu Ser Gly Gly Arg His Leu Asp Arg Ser 
                645                 650                 655     


Pro Glu Ser Asp Arg Pro Arg Lys Arg His Cys Ala Pro Ser Pro Asp 
            660                 665                 670         


Arg Ser Pro Glu Leu Ser Ser Ser Arg Asp Arg Tyr Asn Ser Asp Asn 
        675                 680                 685             


Asp Arg Ser Ser Arg Leu Leu Leu Glu Arg Pro Ser Pro Ile Arg Asp 
    690                 695                 700                 


Arg Arg Gly Ser Leu Glu Lys Ser Gln Gly Asp Lys Arg Asp Arg Lys 
705                 710                 715                 720 


Asn Ser Ala Ser Ala Glu Arg Asp Arg Lys His Arg Thr Thr Ala Pro 
                725                 730                 735     


Thr Glu Gly Lys Ser Pro Leu Lys Lys Glu Asp Arg Ser Asp Gly Ser 
            740                 745                 750         


Ala Pro Ser Thr Ser Thr Ala Ser Ser Lys Leu Lys Ser Pro Ser Gln 
        755                 760                 765             


Lys Gln Asp Gly Gly Thr Ala Pro Val Ala Ser Ala Ser Pro Lys Leu 
    770                 775                 780                 


Cys Leu Ala Trp Gln Gly Met Leu Leu Leu Lys Asn Ser Asn Phe Pro 
785                 790                 795                 800 


Ser Asn Met His Leu Leu Gln Gly Asp Leu Gln Val Ala Ser Ser Leu 
                805                 810                 815     


Leu Val Glu Gly Ser Thr Gly Gly Lys Val Ala Gln Leu Lys Ile Thr 
            820                 825                 830         


Gln Arg Leu Arg Leu Asp Gln Pro Lys Leu Asp Glu Val Thr Arg Arg 
        835                 840                 845             


Ile Lys Val Ala Gly Pro Asn Gly Tyr Ala Ile Leu Leu Ala Val Pro 
    850                 855                 860                 


Gly Ser Ser Asp Ser Arg Ser Ser Ser Ser Ser Ala Ala Ser Asp Thr 
865                 870                 875                 880 


Ala Thr Ser Thr Gln Arg Pro Leu Arg Asn Leu Val Ser Tyr Leu Lys 
                885                 890                 895     


Gln Lys Gln Ala Ala Gly Val Ile Ser Leu Pro Val Gly Gly Asn Lys 
            900                 905                 910         


Asp Lys Glu Asn Thr Gly Val Leu His Ala Phe Pro Pro Cys Glu Phe 
        915                 920                 925             


Ser Gln Gln Phe Leu Asp Ser Pro Ala Lys Ala Leu Ala Lys Ser Glu 
    930                 935                 940                 


Glu Asp Tyr Leu Val Met Ile Ile Val Arg Gly Phe Gly Phe Gln Ile 
945                 950                 955                 960 


Gly Val Arg Tyr Glu Asn Lys Lys Arg Glu Asn Leu Ala Leu Thr Leu 
                965                 970                 975     


Leu 
    


<210>  168
<211>  423
<212>  PRT
<213>  Homo sapiens;

<400>  168

Met Ala Ser Asp Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala 
1               5                   10                  15      


Pro Tyr Lys Lys Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys 
            20                  25                  30          


Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu 
        35                  40                  45              


Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Asn Arg Ser Arg Asp 
    50                  55                  60                  


Arg Asp Arg Tyr Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg 
65                  70                  75                  80  


Gln Cys Arg His Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu 
                85                  90                  95      


Ser Arg Ser Arg Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser 
            100                 105                 110         


Pro Pro Leu Ala Thr Gly Tyr Arg Tyr Gly His Ser Lys Ser Pro His 
        115                 120                 125             


Phe Arg Glu Lys Ser Pro Val Arg Glu Pro Val Asp Asn Leu Ser Pro 
    130                 135                 140                 


Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Pro Arg Asp Leu Glu Asp Phe Phe Ser Ala Val Gly Lys Val 
                165                 170                 175     


Arg Asp Val Arg Ile Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly 
            180                 185                 190         


Ile Ala Tyr Val Glu Phe Cys Glu Ile Gln Ser Val Pro Leu Ala Ile 
        195                 200                 205             


Gly Leu Thr Gly Gln Arg Leu Leu Gly Val Pro Ile Ile Val Gln Ala 
    210                 215                 220                 


Ser Gln Ala Glu Lys Asn Arg Leu Ala Ala Met Ala Asn Asn Leu Gln 
225                 230                 235                 240 


Lys Gly Asn Gly Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe 
                245                 250                 255     


Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys 
            260                 265                 270         


Ile Asp Asn Ile Val Leu Met Lys Asp Ser Asp Thr Gly Arg Ser Lys 
        275                 280                 285             


Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala 
    290                 295                 300                 


Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro Met Arg Val 
305                 310                 315                 320 


Gly His Val Thr Glu Arg Leu Asp Gly Gly Thr Asp Ile Thr Phe Pro 
                325                 330                 335     


Asp Gly Asp Gln Glu Leu Asp Leu Gly Ser Ala Gly Gly Arg Phe Gln 
            340                 345                 350         


Leu Met Ala Lys Leu Ala Glu Gly Ala Gly Ile Gln Leu Pro Ser Thr 
        355                 360                 365             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ala Ala Ala Leu Gln Leu 
    370                 375                 380                 


Asn Gly Ala Val Pro Leu Gly Ala Leu Asn Pro Ala Ala Leu Thr Ala 
385                 390                 395                 400 


Leu Ser Pro Ala Leu Asn Leu Ala Ser Gln Cys Phe Gln Leu Ser Ser 
                405                 410                 415     


Leu Phe Thr Pro Gln Thr Met 
            420             


<210>  169
<211>  1147
<212>  PRT
<213>  Homo sapiens;

<400>  169

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
1               5                   10                  15      


Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
            20                  25                  30          


Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
        35                  40                  45              


Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
    50                  55                  60                  


Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
65                  70                  75                  80  


Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                85                  90                  95      


Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
            100                 105                 110         


Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
        115                 120                 125             


Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
    130                 135                 140                 


Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
145                 150                 155                 160 


Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                165                 170                 175     


Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
            180                 185                 190         


Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
        195                 200                 205             


Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
    210                 215                 220                 


Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
225                 230                 235                 240 


Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                245                 250                 255     


Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
            260                 265                 270         


Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
        275                 280                 285             


Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
    290                 295                 300                 


Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
305                 310                 315                 320 


Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                325                 330                 335     


Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
            340                 345                 350         


Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
        355                 360                 365             


Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
    370                 375                 380                 


Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
385                 390                 395                 400 


Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                405                 410                 415     


Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
            420                 425                 430         


Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
        435                 440                 445             


Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
    450                 455                 460                 


Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
465                 470                 475                 480 


Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                485                 490                 495     


Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
            500                 505                 510         


Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
        515                 520                 525             


Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
    530                 535                 540                 


Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
545                 550                 555                 560 


Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                565                 570                 575     


Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
            580                 585                 590         


Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
        595                 600                 605             


Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
    610                 615                 620                 


Asp Lys Lys His Ala Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp Gly 
625                 630                 635                 640 


Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
                645                 650                 655     


Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
            660                 665                 670         


Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala Ile 
        675                 680                 685             


Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser Asn 
    690                 695                 700                 


Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp Glu 
705                 710                 715                 720 


Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
                725                 730                 735     


Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
            740                 745                 750         


Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
        755                 760                 765             


Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met Met 
    770                 775                 780                 


Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
785                 790                 795                 800 


Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His Asn 
                805                 810                 815     


Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln Ala 
            820                 825                 830         


Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro Phe 
        835                 840                 845             


Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His Met 
    850                 855                 860                 


Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
865                 870                 875                 880 


Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala Ala 
                885                 890                 895     


Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
            900                 905                 910         


Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys Gln 
        915                 920                 925             


Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu Pro 
    930                 935                 940                 


Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro Ser 
945                 950                 955                 960 


Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val Gln 
                965                 970                 975     


Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
            980                 985                 990         


Val Asn Met Asp Tyr Leu Ser Leu  Leu Arg Asp Ala Leu  Val Gln Pro 
        995                 1000                 1005             


Leu Thr  Ser Gln Gly Val Asp  Gly Val Gln Asp Val  Val Ala Leu 
    1010                 1015                 1020             


Met Asp  Thr Tyr Tyr Leu Met  Lys Glu Asp Phe Glu  Asn Ile Met 
    1025                 1030                 1035             


Glu Ile  Ser Ser Trp Gly Gly  Lys Pro Ser Pro Phe  Ser Lys Leu 
    1040                 1045                 1050             


Asp Pro  Lys Val Lys Ala Ala  Phe Thr Arg Ala Tyr  Asn Lys Glu 
    1055                 1060                 1065             


Ala His  Leu Thr Pro Tyr Ser  Leu Gln Ala Ile Lys  Ala Ser Arg 
    1070                 1075                 1080             


His Ser  Thr Ser Pro Ser Leu  Asp Ser Glu Tyr Asn  Glu Glu Leu 
    1085                 1090                 1095             


Asn Glu  Asp Asp Ser Gln Ser  Asp Glu Lys Asp Gln  Asp Ala Ile 
    1100                 1105                 1110             


Glu Thr  Asp Ala Met Ile Lys  Lys Lys Thr Lys Ser  Ser Lys Pro 
    1115                 1120                 1125             


Ser Lys  Pro Glu Lys Asp Lys  Glu Pro Arg Lys Gly  Lys Gly Lys 
    1130                 1135                 1140             


Ser Ser  Lys Lys 
    1145         


<210>  170
<211>  150
<212>  PRT
<213>  Homo sapiens;

<400>  170

Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu Leu Val Leu Trp Gly 
1               5                   10                  15      


Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg Leu Thr Lys Ala His 
            20                  25                  30          


Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys Asn Arg 
        35                  40                  45              


Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His Cys Lys His Gln Asn 
    50                  55                  60                  


Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala Ala Val Cys Asp Leu 
65                  70                  75                  80  


Leu Ser Ile Val Cys Lys Asn Arg Arg His Asn Cys His Gln Ser Ser 
                85                  90                  95      


Lys Pro Val Asn Met Thr Asp Cys Arg Leu Thr Ser Gly Lys Tyr Pro 
            100                 105                 110         


Gln Cys Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe Ile Val Ala 
        115                 120                 125             


Cys Asp Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val 
    130                 135                 140                 


His Leu Asp Ser Ile Leu 
145                 150 


<210>  171
<211>  499
<212>  PRT
<213>  Homo sapiens;

<400>  171

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg 
            340                 345                 350         


Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro 
        355                 360                 365             


Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser 
    370                 375                 380                 


Gly Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu 
385                 390                 395                 400 


Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln 
                405                 410                 415     


Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Gly Ser Tyr 
            420                 425                 430         


Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Leu 
        435                 440                 445             


Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn 
    450                 455                 460                 


Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser 
465                 470                 475                 480 


Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp 
                485                 490                 495     


Arg Pro Tyr 
            


<210>  172
<211>  607
<212>  PRT
<213>  Homo sapiens;

<400>  172

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  173
<211>  1048
<212>  PRT
<213>  Homo sapiens;

<400>  173

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  174
<211>  862
<212>  PRT
<213>  Homo sapiens;

<400>  174

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  175
<211>  827
<212>  PRT
<213>  Homo sapiens;

<400>  175

Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Val Thr Ala Val Arg Val 
65                  70                  75                  80  


Tyr Val Asn Ser Ser Ser Glu Asn Leu Asn Tyr Pro Val Leu Val Val 
                85                  90                  95      


Val Arg Gln Gln Lys Glu Val Leu Ser Trp Gln Val Pro Leu Leu Phe 
            100                 105                 110         


Gln Gly Leu Tyr Gln Arg Ser Tyr Asn Tyr Gln Glu Val Ser Arg Thr 
        115                 120                 125             


Leu Cys Pro Ser Glu Ala Thr Asn Glu Thr Gly Pro Leu Gln Gln Leu 
    130                 135                 140                 


Ile Phe Val Asp Val Ala Ser Met Ala Pro Leu Gly Ala Gln Tyr Lys 
145                 150                 155                 160 


Leu Leu Val Thr Lys Leu Lys His Phe Gln Leu Arg Thr Asn Val Ala 
                165                 170                 175     


Phe His Phe Thr Ala Ser Pro Ser Gln Pro Gln Tyr Phe Leu Tyr Lys 
            180                 185                 190         


Phe Pro Lys Asp Val Asp Ser Val Ile Ile Lys Val Val Ser Glu Met 
        195                 200                 205             


Ala Tyr Pro Cys Ser Val Val Ser Val Gln Asn Ile Met Cys Pro Val 
    210                 215                 220                 


Tyr Asp Leu Asp His Asn Val Glu Phe Asn Gly Val Tyr Gln Ser Met 
225                 230                 235                 240 


Thr Lys Lys Ala Ala Ile Thr Leu Gln Lys Lys Asp Phe Pro Gly Glu 
                245                 250                 255     


Gln Phe Phe Val Val Phe Val Ile Lys Pro Glu Asp Tyr Ala Cys Gly 
            260                 265                 270         


Gly Ser Phe Phe Ile Gln Glu Lys Glu Asn Gln Thr Trp Asn Leu Gln 
        275                 280                 285             


Arg Lys Lys Asn Leu Glu Val Thr Ile Val Pro Ser Ile Lys Glu Ser 
    290                 295                 300                 


Val Tyr Val Lys Ser Ser Leu Phe Ser Val Phe Ile Phe Leu Ser Phe 
305                 310                 315                 320 


Tyr Leu Gly Cys Leu Leu Val Gly Phe Val His Tyr Leu Arg Phe Gln 
                325                 330                 335     


Arg Lys Ser Ile Asp Gly Ser Phe Gly Ser Asn Asp Gly Ser Gly Asn 
            340                 345                 350         


Met Val Ala Ser His Pro Ile Ala Ala Ser Thr Pro Glu Gly Ser Asn 
        355                 360                 365             


Tyr Gly Thr Ile Asp Glu Ser Ser Ser Ser Pro Gly Arg Gln Met Ser 
    370                 375                 380                 


Ser Ser Asp Gly Gly Pro Pro Gly Gln Ser Asp Thr Asp Ser Ser Val 
385                 390                 395                 400 


Glu Glu Ser Asp Phe Asp Thr Met Pro Asp Ile Glu Ser Asp Lys Asn 
                405                 410                 415     


Ile Ile Arg Thr Lys Met Phe Leu Tyr Leu Ser Asp Leu Ser Arg Lys 
            420                 425                 430         


Asp Arg Arg Ile Val Ser Lys Lys Tyr Lys Ile Tyr Phe Trp Asn Ile 
        435                 440                 445             


Ile Thr Ile Ala Val Phe Tyr Ala Leu Pro Val Ile Gln Leu Val Ile 
    450                 455                 460                 


Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn Gln Asp Ile Cys Tyr 
465                 470                 475                 480 


Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Val Leu Ser Ala Phe Asn 
                485                 490                 495     


Asn Ile Leu Ser Asn Leu Gly His Val Leu Leu Gly Phe Leu Phe Leu 
            500                 505                 510         


Leu Ile Val Leu Arg Arg Asp Ile Leu His Arg Arg Ala Leu Glu Ala 
        515                 520                 525             


Lys Asp Ile Phe Ala Val Glu Tyr Gly Ile Pro Lys His Phe Gly Leu 
    530                 535                 540                 


Phe Tyr Ala Met Gly Ile Ala Leu Met Met Glu Gly Val Leu Ser Ala 
545                 550                 555                 560 


Cys Tyr His Val Cys Pro Asn Tyr Ser Asn Phe Gln Phe Asp Thr Ser 
                565                 570                 575     


Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu Lys Leu Tyr Gln Thr 
            580                 585                 590         


Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser Ala Tyr Ala Ser Phe 
        595                 600                 605             


Ala Val Val Ile Met Val Thr Val Leu Gly Val Val Phe Gly Lys Asn 
    610                 615                 620                 


Asp Val Trp Phe Trp Val Ile Phe Ser Ala Ile His Val Leu Ala Ser 
625                 630                 635                 640 


Leu Ala Leu Ser Thr Gln Ile Tyr Tyr Met Gly Arg Phe Lys Ile Asp 
                645                 650                 655     


Leu Gly Ile Phe Arg Arg Ala Ala Met Val Phe Tyr Thr Asp Cys Ile 
            660                 665                 670         


Gln Gln Cys Ser Arg Pro Leu Tyr Met Asp Arg Met Val Leu Leu Val 
        675                 680                 685             


Val Gly Asn Leu Val Asn Trp Ser Phe Ala Leu Phe Gly Leu Ile Tyr 
    690                 695                 700                 


Arg Pro Arg Asp Phe Ala Ser Tyr Met Leu Gly Ile Phe Ile Cys Asn 
705                 710                 715                 720 


Leu Leu Leu Tyr Leu Ala Phe Tyr Ile Ile Met Lys Leu Arg Ser Ser 
                725                 730                 735     


Glu Lys Val Leu Pro Val Pro Leu Phe Cys Ile Val Ala Thr Ala Val 
            740                 745                 750         


Met Trp Ala Ala Ala Leu Tyr Phe Phe Phe Gln Asn Leu Ser Ser Trp 
        755                 760                 765             


Glu Gly Thr Pro Ala Glu Ser Arg Glu Lys Asn Arg Glu Cys Ile Leu 
    770                 775                 780                 


Leu Asp Phe Phe Asp Asp His Asp Ile Trp His Phe Leu Ser Ala Thr 
785                 790                 795                 800 


Ala Leu Phe Phe Ser Phe Leu Val Leu Leu Thr Leu Asp Asp Asp Leu 
                805                 810                 815     


Asp Val Val Arg Arg Asp Gln Ile Pro Val Phe 
            820                 825         


<210>  176
<211>  453
<212>  PRT
<213>  Homo sapiens;

<400>  176

Met Ala Leu Val Arg Ala Leu Val Cys Cys Leu Leu Thr Ala Trp His 
1               5                   10                  15      


Cys Arg Ser Gly Leu Gly Leu Pro Val Ala Pro Ala Gly Gly Arg Asn 
            20                  25                  30          


Pro Pro Pro Ala Ile Gly Gln Phe Trp His Val Thr Asp Leu His Leu 
        35                  40                  45              


Asp Pro Thr Tyr His Ile Thr Asp Asp His Thr Lys Val Cys Ala Ser 
    50                  55                  60                  


Ser Lys Gly Ala Asn Ala Ser Asn Pro Gly Pro Phe Gly Asp Val Leu 
65                  70                  75                  80  


Cys Asp Ser Pro Tyr Gln Leu Ile Leu Ser Ala Phe Asp Phe Ile Lys 
                85                  90                  95      


Asn Ser Gly Gln Glu Ala Ser Phe Met Ile Trp Thr Gly Asp Ser Pro 
            100                 105                 110         


Pro His Val Pro Val Pro Glu Leu Ser Thr Asp Thr Val Ile Asn Val 
        115                 120                 125             


Ile Thr Asn Met Thr Thr Thr Ile Gln Ser Leu Phe Pro Asn Leu Gln 
    130                 135                 140                 


Val Phe Pro Ala Leu Gly Asn His Asp Tyr Trp Pro Gln Asp Gln Leu 
145                 150                 155                 160 


Pro Val Val Thr Ser Lys Val Tyr Asn Ala Val Ala Asn Leu Trp Lys 
                165                 170                 175     


Pro Trp Leu Asp Glu Glu Ala Ile Ser Thr Leu Arg Lys Gly Gly Phe 
            180                 185                 190         


Tyr Ser Gln Lys Val Thr Thr Asn Pro Asn Leu Arg Ile Ile Ser Leu 
        195                 200                 205             


Asn Thr Asn Leu Tyr Tyr Gly Pro Asn Ile Met Thr Leu Asn Lys Thr 
    210                 215                 220                 


Asp Pro Ala Asn Gln Phe Glu Trp Leu Glu Ser Thr Leu Asn Asn Ser 
225                 230                 235                 240 


Gln Gln Asn Lys Glu Lys Val Tyr Ile Ile Ala His Val Pro Val Gly 
                245                 250                 255     


Tyr Leu Pro Ser Ser Gln Asn Ile Thr Ala Met Arg Glu Tyr Tyr Asn 
            260                 265                 270         


Glu Lys Leu Ile Asp Ile Phe Gln Lys Tyr Ser Asp Val Ile Ala Gly 
        275                 280                 285             


Gln Phe Tyr Gly His Thr His Arg Asp Ser Ile Met Val Leu Ser Asp 
    290                 295                 300                 


Lys Lys Gly Ser Pro Val Asn Ser Leu Phe Val Ala Pro Ala Val Thr 
305                 310                 315                 320 


Pro Val Lys Ser Val Leu Glu Lys Gln Thr Asn Asn Pro Gly Ile Arg 
                325                 330                 335     


Leu Phe Gln Tyr Asp Pro Arg Asp Tyr Lys Leu Leu Asp Met Leu Gln 
            340                 345                 350         


Tyr Tyr Leu Asn Leu Thr Glu Ala Asn Leu Lys Gly Glu Ser Ile Trp 
        355                 360                 365             


Lys Leu Glu Tyr Ile Leu Thr Gln Thr Tyr Asp Ile Glu Asp Leu Gln 
    370                 375                 380                 


Pro Glu Ser Leu Tyr Gly Leu Ala Lys Gln Phe Thr Ile Leu Asp Ser 
385                 390                 395                 400 


Lys Gln Phe Ile Lys Tyr Tyr Asn Tyr Phe Phe Val Ser Tyr Asp Ser 
                405                 410                 415     


Ser Val Thr Cys Asp Lys Thr Cys Lys Ala Phe Gln Ile Cys Ala Ile 
            420                 425                 430         


Met Asn Leu Asp Asn Ile Ser Tyr Ala Asp Cys Leu Lys Gln Leu Tyr 
        435                 440                 445             


Ile Lys His Asn Tyr 
    450             


<210>  177
<211>  262
<212>  PRT
<213>  Homo sapiens;

<400>  177

Met Lys Thr Pro Phe Gly Lys Thr Pro Gly Gln Arg Ser Arg Ala Asp 
1               5                   10                  15      


Ala Gly His Ala Gly Val Ser Ala Asn Met Met Lys Lys Arg Thr Ser 
            20                  25                  30          


His Lys Lys His Arg Ser Ser Val Gly Pro Ser Lys Pro Val Ser Gln 
        35                  40                  45              


Pro Arg Arg Asn Ile Val Gly Cys Arg Ile Gln His Gly Trp Lys Glu 
    50                  55                  60                  


Gly Asn Gly Pro Val Thr Gln Trp Lys Gly Thr Val Leu Asp Gln Val 
65                  70                  75                  80  


Pro Val Asn Pro Ser Leu Tyr Leu Ile Lys Tyr Asp Gly Phe Asp Cys 
                85                  90                  95      


Val Tyr Gly Leu Glu Leu Asn Lys Asp Glu Arg Val Ser Ala Leu Glu 
            100                 105                 110         


Val Leu Pro Asp Arg Val Ala Thr Ser Arg Ile Ser Asp Ala His Leu 
        115                 120                 125             


Ala Asp Thr Met Ile Gly Lys Ala Val Glu His Met Phe Glu Thr Glu 
    130                 135                 140                 


Asp Gly Ser Lys Asp Glu Trp Arg Gly Met Val Leu Ala Arg Ala Pro 
145                 150                 155                 160 


Val Met Asn Thr Trp Phe Tyr Ile Thr Tyr Glu Lys Asp Pro Val Leu 
                165                 170                 175     


Tyr Met Tyr Gln Leu Leu Asp Asp Tyr Lys Glu Gly Asp Leu Arg Ile 
            180                 185                 190         


Met Pro Asp Ser Asn Asp Ser Pro Pro Ala Glu Arg Glu Pro Gly Glu 
        195                 200                 205             


Val Val Asp Ser Leu Val Gly Lys Gln Val Glu Tyr Ala Lys Glu Asp 
    210                 215                 220                 


Gly Ser Lys Arg Thr Gly Met Val Ile His Gln Val Glu Ala Lys Pro 
225                 230                 235                 240 


Ser Val Tyr Phe Ile Lys Phe Asp Asp Asp Phe His Ile Tyr Val Tyr 
                245                 250                 255     


Asp Leu Val Lys Thr Ser 
            260         


<210>  178
<211>  350
<212>  PRT
<213>  Homo sapiens;

<400>  178

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu 
1               5                   10                  15      


Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
            20                  25                  30          


Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Asp Gly Thr His Arg Val 
        35                  40                  45              


Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Arg 
    50                  55                  60                  


Leu Ser Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Ala Gly 
65                  70                  75                  80  


Ala Ser Asp Trp Phe Asp Ser His Phe Asp Gly Asn Ile Ser Pro Val 
                85                  90                  95      


Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp 
            100                 105                 110         


Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
        115                 120                 125             


Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
    130                 135                 140                 


Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
145                 150                 155                 160 


Leu Arg Gly Ser Gly Tyr Gly Gln Asp Val Asp Gly His Asn Phe Ile 
                165                 170                 175     


Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly 
            180                 185                 190         


Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
        195                 200                 205             


Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Val Leu Asp Leu 
    210                 215                 220                 


Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
225                 230                 235                 240 


Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                245                 250                 255     


Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
            260                 265                 270         


His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
        275                 280                 285             


His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
    290                 295                 300                 


Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
305                 310                 315                 320 


Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                325                 330                 335     


Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
            340                 345                 350 


<210>  179
<211>  910
<212>  PRT
<213>  Homo sapiens;

<400>  179

Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met 
1               5                   10                  15      


Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg 
            20                  25                  30          


Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn 
        35                  40                  45              


Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp 
    50                  55                  60                  


Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg 
65                  70                  75                  80  


Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys 
                85                  90                  95      


Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu 
            100                 105                 110         


Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser 
        115                 120                 125             


Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser 
    130                 135                 140                 


Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn 
145                 150                 155                 160 


Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr 
                165                 170                 175     


Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser 
            180                 185                 190         


Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp 
        195                 200                 205             


Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu 
    210                 215                 220                 


Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met 
225                 230                 235                 240 


Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro 
                245                 250                 255     


Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile 
            260                 265                 270         


Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg 
        275                 280                 285             


Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu 
    290                 295                 300                 


Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn 
305                 310                 315                 320 


Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala 
                325                 330                 335     


Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu 
            340                 345                 350         


Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met 
        355                 360                 365             


Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser 
    370                 375                 380                 


Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr 
385                 390                 395                 400 


Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro 
                405                 410                 415     


Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln 
            420                 425                 430         


Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser 
        435                 440                 445             


Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Asp Glu 
    450                 455                 460                 


Leu Ser His Cys Val Glu Pro Glu Pro Ser Gln Val Pro Gly Gly Ser 
465                 470                 475                 480 


Ser Arg Asp Arg Gln Gln Gly Ser Glu Glu Glu Pro Ser Pro Val Leu 
                485                 490                 495     


Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu 
            500                 505                 510         


Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln 
        515                 520                 525             


Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro Asp Gln 
    530                 535                 540                 


Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val Pro Thr 
545                 550                 555                 560 


Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser 
                565                 570                 575     


Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Val Ser Gly Ser Val Met 
            580                 585                 590         


Ser Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn Ile 
        595                 600                 605             


Gln Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val Phe 
    610                 615                 620                 


Val Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln Arg 
625                 630                 635                 640 


Ser Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met 
                645                 650                 655     


Gly Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val Tyr 
            660                 665                 670         


Asn Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln 
        675                 680                 685             


Lys Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn Ser 
    690                 695                 700                 


Phe Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn 
705                 710                 715                 720 


Lys Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala 
                725                 730                 735     


Pro Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala Leu 
            740                 745                 750         


Gln Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr Gly 
        755                 760                 765             


Glu Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg 
    770                 775                 780                 


Gly Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp Thr 
785                 790                 795                 800 


Ser Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr Asn 
                805                 810                 815     


Pro Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu Asp 
            820                 825                 830         


Leu Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys Leu 
        835                 840                 845             


Thr Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys 
    850                 855                 860                 


Ser Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu Val 
865                 870                 875                 880 


Ala Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu Ala 
                885                 890                 895     


Thr Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys 
            900                 905                 910 


<210>  180
<211>  851
<212>  PRT
<213>  Homo sapiens;

<400>  180

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  181
<211>  772
<212>  PRT
<213>  Homo sapiens;

<400>  181

Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile 
            340                 345                 350         


Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala 
        355                 360                 365             


Ala Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr 
    370                 375                 380                 


Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val 
                405                 410                 415     


Ser Phe Gly Ala Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr 
            420                 425                 430         


Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr 
        435                 440                 445             


Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro 
    450                 455                 460                 


His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile 
465                 470                 475                 480 


Asn Thr Leu Ser His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn 
                485                 490                 495     


Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp 
            500                 505                 510         


Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys 
        515                 520                 525             


Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly 
    530                 535                 540                 


Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp 
545                 550                 555                 560 


Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala 
                565                 570                 575     


Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe 
            580                 585                 590         


Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln 
        595                 600                 605             


Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile 
    610                 615                 620                 


Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn 
625                 630                 635                 640 


Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His 
                645                 650                 655     


Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu 
            660                 665                 670         


Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His 
        675                 680                 685             


Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu 
    690                 695                 700                 


Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys 
705                 710                 715                 720 


Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe 
                725                 730                 735     


Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp 
            740                 745                 750         


Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr 
        755                 760                 765             


Glu Val Ile Tyr 
    770         


<210>  182
<211>  858
<212>  PRT
<213>  Homo sapiens;

<400>  182

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  183
<211>  324
<212>  PRT
<213>  Homo sapiens;

<400>  183

Met Ala Ala Ala Ala Pro Gly Asn Gly Arg Ala Ser Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Val Pro Leu Leu Trp Ala Pro Ala Ala Val Arg 
            20                  25                  30          


Ala Gly Pro Asp Glu Asp Leu Ser His Arg Asn Lys Glu Pro Pro Ala 
        35                  40                  45              


Pro Ala Gln Gln Leu Gln Pro Gln Pro Val Ala Val Gln Gly Pro Glu 
    50                  55                  60                  


Pro Ala Arg Val Glu Lys Ile Phe Thr Pro Ala Ala Pro Val His Thr 
65                  70                  75                  80  


Asn Lys Glu Asp Pro Ala Thr Gln Thr Asn Leu Gly Phe Ile His Ala 
                85                  90                  95      


Phe Val Ala Ala Ile Ser Val Ile Ile Val Ser Glu Leu Gly Asp Lys 
            100                 105                 110         


Thr Phe Phe Ile Ala Ala Ile Met Ala Met Arg Tyr Asn Arg Leu Thr 
        115                 120                 125             


Val Leu Ala Gly Ala Met Leu Ala Leu Gly Leu Met Thr Cys Leu Ser 
    130                 135                 140                 


Val Leu Phe Gly Tyr Ala Thr Thr Val Ile Pro Arg Val Tyr Thr Tyr 
145                 150                 155                 160 


Tyr Val Ser Thr Val Leu Phe Ala Ile Phe Gly Ile Arg Met Leu Arg 
                165                 170                 175     


Glu Gly Leu Lys Met Ser Pro Asp Glu Gly Gln Glu Glu Leu Glu Glu 
            180                 185                 190         


Val Gln Ala Glu Leu Lys Lys Lys Asp Glu Glu Phe Gln Arg Thr Lys 
        195                 200                 205             


Leu Leu Asn Gly Pro Gly Asp Val Glu Thr Gly Thr Ser Ile Thr Val 
    210                 215                 220                 


Pro Gln Lys Lys Trp Leu His Phe Ile Ser Pro Ile Phe Val Gln Ala 
225                 230                 235                 240 


Leu Thr Leu Thr Phe Leu Ala Glu Trp Gly Asp Arg Ser Gln Leu Thr 
                245                 250                 255     


Thr Ile Val Leu Ala Ala Arg Glu Asp Pro Tyr Gly Val Ala Val Gly 
            260                 265                 270         


Gly Thr Val Gly His Cys Leu Cys Thr Gly Leu Ala Val Ile Gly Gly 
        275                 280                 285             


Arg Met Ile Ala Gln Lys Ile Ser Val Arg Thr Val Thr Ile Ile Gly 
    290                 295                 300                 


Gly Ile Val Phe Leu Ala Phe Ala Phe Ser Ala Leu Phe Ile Ser Pro 
305                 310                 315                 320 


Asp Ser Gly Phe 
                


<210>  184
<211>  169
<212>  PRT
<213>  Homo sapiens;

<400>  184

Met Ala Pro Pro Trp Val Pro Ala Met Gly Phe Thr Leu Ala Pro Ser 
1               5                   10                  15      


Leu Gly Cys Phe Val Gly Ser Arg Phe Val His Gly Glu Gly Leu Arg 
            20                  25                  30          


Trp Tyr Ala Gly Leu Gln Lys Pro Ser Trp His Pro Pro His Trp Val 
        35                  40                  45              


Leu Gly Pro Val Trp Gly Thr Leu Tyr Ser Ala Met Gly Tyr Gly Ser 
    50                  55                  60                  


Tyr Leu Val Trp Lys Glu Leu Gly Gly Phe Thr Glu Lys Ala Val Val 
65                  70                  75                  80  


Pro Leu Gly Leu Tyr Thr Gly Gln Leu Ala Leu Asn Trp Ala Trp Pro 
                85                  90                  95      


Pro Ile Phe Phe Gly Ala Arg Gln Met Gly Trp Ala Leu Val Asp Leu 
            100                 105                 110         


Leu Leu Val Ser Gly Ala Ala Ala Ala Thr Thr Val Ala Trp Tyr Gln 
        115                 120                 125             


Val Ser Pro Leu Ala Ala Arg Leu Leu Tyr Pro Tyr Leu Ala Trp Leu 
    130                 135                 140                 


Ala Phe Thr Thr Thr Leu Asn Tyr Cys Val Trp Arg Asp Asn His Gly 
145                 150                 155                 160 


Trp Arg Gly Gly Arg Arg Leu Pro Glu 
                165                 


<210>  185
<211>  3433
<212>  PRT
<213>  Homo sapiens;

<400>  185

Met Ala Lys Tyr Gly Glu His Glu Ala Ser Pro Asp Asn Gly Gln Asn 
1               5                   10                  15      


Glu Phe Ser Asp Ile Ile Lys Ser Arg Ser Asp Glu His Asn Asp Val 
            20                  25                  30          


Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Arg Phe Ser Lys Ser 
        35                  40                  45              


Gly Lys Pro Pro Ile Asn Asp Met Phe Thr Asp Leu Lys Asp Gly Arg 
    50                  55                  60                  


Lys Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Thr Ser Leu Pro Lys 
65                  70                  75                  80  


Glu Arg Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Arg Val 
                85                  90                  95      


Leu Gln Val Leu His Gln Asn Asn Val Glu Leu Val Asn Ile Gly Gly 
            100                 105                 110         


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Leu Trp 
        115                 120                 125             


Ser Ile Ile Leu His Trp Gln Val Lys Asp Val Met Lys Asp Val Met 
    130                 135                 140                 


Ser Asp Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Thr Arg Pro Tyr Ser Gln Val Asn Val Leu Asn Phe Thr 
                165                 170                 175     


Thr Ser Trp Thr Asp Gly Leu Ala Phe Asn Ala Val Leu His Arg His 
            180                 185                 190         


Lys Pro Asp Leu Phe Ser Trp Asp Lys Val Val Lys Met Ser Pro Ile 
        195                 200                 205             


Glu Arg Leu Glu His Ala Phe Ser Lys Ala Gln Thr Tyr Leu Gly Ile 
    210                 215                 220                 


Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Val Gln Leu Pro Asp Lys 
225                 230                 235                 240 


Lys Ser Ile Ile Met Tyr Leu Thr Ser Leu Phe Glu Val Leu Pro Gln 
                245                 250                 255     


Gln Val Thr Ile Asp Ala Ile Arg Glu Val Glu Thr Leu Pro Arg Lys 
            260                 265                 270         


Tyr Lys Lys Glu Cys Glu Glu Glu Ala Ile Asn Ile Gln Ser Thr Ala 
        275                 280                 285             


Pro Glu Glu Glu His Glu Ser Pro Arg Ala Glu Thr Pro Ser Thr Val 
    290                 295                 300                 


Thr Glu Val Asp Met Asp Leu Asp Ser Tyr Gln Ile Ala Leu Glu Glu 
305                 310                 315                 320 


Val Leu Thr Trp Leu Leu Ser Ala Glu Asp Thr Phe Gln Glu Gln Asp 
                325                 330                 335     


Asp Ile Ser Asp Asp Val Glu Glu Val Lys Asp Gln Phe Ala Thr His 
            340                 345                 350         


Glu Ala Phe Met Met Glu Leu Thr Ala His Gln Ser Ser Val Gly Ser 
        355                 360                 365             


Val Leu Gln Ala Gly Asn Gln Leu Ile Thr Gln Gly Thr Leu Ser Asp 
    370                 375                 380                 


Glu Glu Glu Phe Glu Ile Gln Glu Gln Met Thr Leu Leu Asn Ala Arg 
385                 390                 395                 400 


Trp Glu Ala Leu Arg Val Glu Ser Met Asp Arg Gln Ser Arg Leu His 
                405                 410                 415     


Asp Val Leu Met Glu Leu Gln Lys Lys Gln Leu Gln Gln Leu Ser Ala 
            420                 425                 430         


Trp Leu Thr Leu Thr Glu Glu Arg Ile Gln Lys Met Glu Thr Cys Pro 
        435                 440                 445             


Leu Asp Asp Asp Val Lys Ser Leu Gln Lys Leu Leu Glu Glu His Lys 
    450                 455                 460                 


Ser Leu Gln Ser Asp Leu Glu Ala Glu Gln Val Lys Val Asn Ser Leu 
465                 470                 475                 480 


Thr His Met Val Val Ile Val Asp Glu Asn Ser Gly Glu Ser Ala Thr 
                485                 490                 495     


Ala Ile Leu Glu Asp Gln Leu Gln Lys Leu Gly Glu Arg Trp Thr Ala 
            500                 505                 510         


Val Cys Arg Trp Thr Glu Glu Arg Trp Asn Arg Leu Gln Glu Ile Asn 
        515                 520                 525             


Ile Leu Trp Gln Glu Leu Leu Glu Glu Gln Cys Leu Leu Lys Ala Trp 
    530                 535                 540                 


Leu Thr Glu Lys Glu Glu Ala Leu Asn Lys Val Gln Thr Ser Asn Phe 
545                 550                 555                 560 


Lys Asp Gln Lys Glu Leu Ser Val Ser Val Arg Arg Leu Ala Ile Leu 
                565                 570                 575     


Lys Glu Asp Met Glu Met Lys Arg Gln Thr Leu Asp Gln Leu Ser Glu 
            580                 585                 590         


Ile Gly Gln Asp Val Gly Gln Leu Leu Asp Asn Ser Lys Ala Ser Lys 
        595                 600                 605             


Lys Ile Asn Ser Asp Ser Glu Glu Leu Thr Gln Arg Trp Asp Ser Leu 
    610                 615                 620                 


Val Gln Arg Leu Glu Asp Ser Ser Asn Gln Val Thr Gln Ala Val Ala 
625                 630                 635                 640 


Lys Leu Gly Met Ser Gln Ile Pro Gln Lys Asp Leu Leu Glu Thr Val 
                645                 650                 655     


Arg Val Arg Glu Gln Ala Ile Thr Lys Lys Ser Lys Gln Glu Leu Pro 
            660                 665                 670         


Pro Pro Pro Pro Pro Lys Lys Arg Gln Ile His Val Asp Ile Glu Ala 
        675                 680                 685             


Lys Lys Lys Phe Asp Ala Ile Ser Ala Glu Leu Leu Asn Trp Ile Leu 
    690                 695                 700                 


Lys Trp Lys Thr Ala Ile Gln Thr Thr Glu Ile Lys Glu Tyr Met Lys 
705                 710                 715                 720 


Met Gln Asp Thr Ser Glu Met Lys Lys Lys Leu Lys Ala Leu Glu Lys 
                725                 730                 735     


Glu Gln Arg Glu Arg Ile Pro Arg Ala Asp Glu Leu Asn Gln Thr Gly 
            740                 745                 750         


Gln Ile Leu Val Glu Gln Met Gly Lys Glu Gly Leu Pro Thr Glu Glu 
        755                 760                 765             


Ile Lys Asn Val Leu Glu Lys Val Ser Ser Glu Trp Lys Asn Val Ser 
    770                 775                 780                 


Gln His Leu Glu Asp Leu Glu Arg Lys Ile Gln Leu Gln Glu Asp Ile 
785                 790                 795                 800 


Asn Ala Tyr Phe Lys Gln Leu Asp Glu Leu Glu Lys Val Ile Lys Thr 
                805                 810                 815     


Lys Glu Glu Trp Val Lys His Thr Ser Ile Ser Glu Ser Ser Arg Gln 
            820                 825                 830         


Ser Leu Pro Ser Leu Lys Asp Ser Cys Gln Arg Glu Leu Thr Asn Leu 
        835                 840                 845             


Leu Gly Leu His Pro Lys Ile Glu Met Ala Arg Ala Ser Cys Ser Ala 
    850                 855                 860                 


Leu Met Ser Gln Pro Ser Ala Pro Asp Phe Val Gln Arg Gly Phe Asp 
865                 870                 875                 880 


Ser Phe Leu Gly Arg Tyr Gln Ala Val Gln Glu Ala Val Glu Asp Arg 
                885                 890                 895     


Gln Gln His Leu Glu Asn Glu Leu Lys Gly Gln Pro Gly His Ala Tyr 
            900                 905                 910         


Leu Glu Thr Leu Lys Thr Leu Lys Asp Val Leu Asn Asp Ser Glu Asn 
        915                 920                 925             


Lys Ala Gln Val Ser Leu Asn Val Leu Asn Asp Leu Ala Lys Val Glu 
    930                 935                 940                 


Lys Ala Leu Gln Glu Lys Lys Thr Leu Asp Glu Ile Leu Glu Asn Gln 
945                 950                 955                 960 


Lys Pro Ala Leu His Lys Leu Ala Glu Glu Thr Lys Ala Leu Glu Lys 
                965                 970                 975     


Asn Val His Pro Asp Val Glu Lys Leu Tyr Lys Gln Glu Phe Asp Asp 
            980                 985                 990         


Val Gln Gly Lys Trp Asn Lys Leu  Lys Val Leu Val Ser  Lys Asp Leu 
        995                 1000                 1005             


His Leu  Leu Glu Glu Ile Ala  Leu Thr Leu Arg Ala  Phe Glu Ala 
    1010                 1015                 1020             


Asp Ser  Thr Val Ile Glu Lys  Trp Met Asp Gly Val  Lys Asp Phe 
    1025                 1030                 1035             


Leu Met  Lys Gln Gln Ala Ala  Gln Gly Asp Asp Ala  Gly Leu Gln 
    1040                 1045                 1050             


Arg Gln  Leu Asp Gln Cys Ser  Ala Phe Val Asn Glu  Ile Glu Thr 
    1055                 1060                 1065             


Ile Glu  Ser Ser Leu Lys Asn  Met Lys Glu Ile Glu  Thr Asn Leu 
    1070                 1075                 1080             


Arg Ser  Gly Pro Val Ala Gly  Ile Lys Thr Trp Val  Gln Thr Arg 
    1085                 1090                 1095             


Leu Gly  Asp Tyr Gln Thr Gln  Leu Glu Lys Leu Ser  Lys Glu Ile 
    1100                 1105                 1110             


Ala Thr  Gln Lys Ser Arg Leu  Ser Glu Ser Gln Glu  Lys Ala Ala 
    1115                 1120                 1125             


Asn Leu  Lys Lys Asp Leu Ala  Glu Met Gln Glu Trp  Met Thr Gln 
    1130                 1135                 1140             


Ala Glu  Glu Glu Tyr Leu Glu  Arg Asp Phe Glu Tyr  Lys Ser Pro 
    1145                 1150                 1155             


Glu Glu  Leu Glu Ser Ala Val  Glu Glu Met Lys Arg  Ala Lys Glu 
    1160                 1165                 1170             


Asp Val  Leu Gln Lys Glu Val  Arg Val Lys Ile Leu  Lys Asp Asn 
    1175                 1180                 1185             


Ile Lys  Leu Leu Ala Ala Lys  Val Pro Ser Gly Gly  Gln Glu Leu 
    1190                 1195                 1200             


Thr Ser  Glu Leu Asn Val Val  Leu Glu Asn Tyr Gln  Leu Leu Cys 
    1205                 1210                 1215             


Asn Arg  Ile Arg Gly Lys Cys  His Thr Leu Glu Glu  Val Trp Ser 
    1220                 1225                 1230             


Cys Trp  Ile Glu Leu Leu His  Tyr Leu Asp Leu Glu  Thr Thr Trp 
    1235                 1240                 1245             


Leu Asn  Thr Leu Glu Glu Arg  Met Lys Ser Thr Glu  Val Leu Pro 
    1250                 1255                 1260             


Glu Lys  Thr Asp Ala Val Asn  Glu Ala Leu Glu Ser  Leu Glu Ser 
    1265                 1270                 1275             


Val Leu  Arg His Pro Ala Asp  Asn Arg Thr Gln Ile  Arg Glu Leu 
    1280                 1285                 1290             


Gly Gln  Thr Leu Ile Asp Gly  Gly Ile Leu Asp Asp  Ile Ile Ser 
    1295                 1300                 1305             


Glu Lys  Leu Glu Ala Phe Asn  Ser Arg Tyr Glu Asp  Leu Ser His 
    1310                 1315                 1320             


Leu Ala  Glu Ser Lys Gln Ile  Ser Leu Glu Lys Gln  Leu Gln Val 
    1325                 1330                 1335             


Leu Arg  Glu Thr Asp Gln Met  Leu Gln Val Leu Gln  Glu Ser Leu 
    1340                 1345                 1350             


Gly Glu  Leu Asp Lys Gln Leu  Thr Thr Tyr Leu Thr  Asp Arg Ile 
    1355                 1360                 1365             


Asp Ala  Phe Gln Val Pro Gln  Glu Ala Gln Lys Ile  Gln Ala Glu 
    1370                 1375                 1380             


Ile Ser  Ala His Glu Leu Thr  Leu Glu Glu Leu Arg  Arg Asn Met 
    1385                 1390                 1395             


Arg Ser  Gln Pro Leu Thr Ser  Pro Glu Ser Arg Thr  Ala Arg Gly 
    1400                 1405                 1410             


Gly Ser  Gln Met Asp Val Leu  Gln Arg Lys Leu Arg  Glu Val Ser 
    1415                 1420                 1425             


Thr Lys  Phe Gln Leu Phe Gln  Lys Pro Ala Asn Phe  Glu Gln Arg 
    1430                 1435                 1440             


Met Leu  Asp Cys Lys Arg Val  Leu Asp Gly Val Lys  Ala Glu Leu 
    1445                 1450                 1455             


His Val  Leu Asp Val Lys Asp  Val Asp Pro Asp Val  Ile Gln Thr 
    1460                 1465                 1470             


His Leu  Asp Lys Cys Met Lys  Leu Tyr Lys Thr Leu  Ser Glu Val 
    1475                 1480                 1485             


Lys Leu  Glu Val Glu Thr Val  Ile Lys Thr Gly Arg  His Ile Val 
    1490                 1495                 1500             


Gln Lys  Gln Gln Thr Asp Asn  Pro Lys Gly Met Asp  Glu Gln Leu 
    1505                 1510                 1515             


Thr Ser  Leu Lys Val Leu Tyr  Asn Asp Leu Gly Ala  Gln Val Thr 
    1520                 1525                 1530             


Glu Gly  Lys Gln Asp Leu Glu  Arg Ala Ser Gln Leu  Ala Arg Lys 
    1535                 1540                 1545             


Met Lys  Lys Glu Ala Ala Ser  Leu Ser Glu Trp Leu  Ser Ala Thr 
    1550                 1555                 1560             


Glu Thr  Glu Leu Val Gln Lys  Ser Thr Ser Glu Gly  Leu Leu Gly 
    1565                 1570                 1575             


Asp Leu  Asp Thr Glu Ile Ser  Trp Ala Lys Asn Val  Leu Lys Asp 
    1580                 1585                 1590             


Leu Glu  Lys Arg Lys Ala Asp  Leu Asn Thr Ile Thr  Glu Ser Ser 
    1595                 1600                 1605             


Ala Ala  Leu Gln Asn Leu Ile  Glu Gly Ser Glu Pro  Ile Leu Glu 
    1610                 1615                 1620             


Glu Arg  Leu Cys Val Leu Asn  Ala Gly Trp Ser Arg  Val Arg Thr 
    1625                 1630                 1635             


Trp Thr  Glu Asp Trp Cys Asn  Thr Leu Met Asn His  Gln Asn Gln 
    1640                 1645                 1650             


Leu Glu  Ile Phe Asp Gly Asn  Val Ala His Ile Ser  Thr Trp Leu 
    1655                 1660                 1665             


Tyr Gln  Ala Glu Ala Leu Leu  Asp Glu Ile Glu Lys  Lys Pro Thr 
    1670                 1675                 1680             


Ser Lys  Gln Glu Glu Ile Val  Lys Arg Leu Val Ser  Glu Leu Asp 
    1685                 1690                 1695             


Asp Ala  Asn Leu Gln Val Glu  Asn Val Arg Asp Gln  Ala Leu Ile 
    1700                 1705                 1710             


Leu Met  Asn Ala Arg Gly Ser  Ser Ser Arg Glu Leu  Val Glu Pro 
    1715                 1720                 1725             


Lys Leu  Ala Glu Leu Asn Arg  Asn Phe Glu Lys Val  Ser Gln His 
    1730                 1735                 1740             


Ile Lys  Ser Ala Lys Leu Leu  Ile Ala Gln Glu Pro  Leu Tyr Gln 
    1745                 1750                 1755             


Cys Leu  Val Thr Thr Glu Thr  Phe Glu Thr Gly Val  Pro Phe Ser 
    1760                 1765                 1770             


Asp Leu  Glu Lys Leu Glu Asn  Asp Ile Glu Asn Met  Leu Lys Phe 
    1775                 1780                 1785             


Val Glu  Lys His Leu Glu Ser  Ser Asp Glu Asp Glu  Lys Met Asp 
    1790                 1795                 1800             


Glu Glu  Ser Ala Gln Ile Glu  Glu Val Leu Gln Arg  Gly Glu Glu 
    1805                 1810                 1815             


Met Leu  His Gln Pro Met Glu  Asp Asn Lys Lys Glu  Lys Ile Arg 
    1820                 1825                 1830             


Leu Gln  Leu Leu Leu Leu His  Thr Arg Tyr Asn Lys  Ile Lys Ala 
    1835                 1840                 1845             


Ile Pro  Ile Gln Gln Arg Lys  Met Gly Gln Leu Ala  Ser Gly Ile 
    1850                 1855                 1860             


Arg Ser  Ser Leu Leu Pro Thr  Asp Tyr Leu Val Glu  Ile Asn Lys 
    1865                 1870                 1875             


Ile Leu  Leu Cys Met Asp Asp  Val Glu Leu Ser Leu  Asn Val Pro 
    1880                 1885                 1890             


Glu Leu  Asn Thr Ala Ile Tyr  Glu Asp Phe Ser Phe  Gln Glu Asp 
    1895                 1900                 1905             


Ser Leu  Lys Asn Ile Lys Asp  Gln Leu Asp Lys Leu  Gly Glu Gln 
    1910                 1915                 1920             


Ile Ala  Val Ile His Glu Lys  Gln Pro Asp Val Ile  Leu Glu Ala 
    1925                 1930                 1935             


Ser Gly  Pro Glu Ala Ile Gln  Ile Arg Asp Thr Leu  Thr Gln Leu 
    1940                 1945                 1950             


Asn Ala  Lys Trp Asp Arg Ile  Asn Arg Met Tyr Ser  Asp Arg Lys 
    1955                 1960                 1965             


Gly Cys  Phe Asp Arg Ala Met  Glu Glu Trp Arg Gln  Phe His Cys 
    1970                 1975                 1980             


Asp Leu  Asn Asp Leu Thr Gln  Trp Ile Thr Glu Ala  Glu Glu Leu 
    1985                 1990                 1995             


Leu Val  Asp Thr Cys Ala Pro  Gly Gly Ser Leu Asp  Leu Glu Lys 
    2000                 2005                 2010             


Ala Arg  Ile His Gln Gln Glu  Leu Glu Val Gly Ile  Ser Ser His 
    2015                 2020                 2025             


Gln Pro  Ser Phe Ala Ala Leu  Asn Arg Thr Gly Asp  Gly Ile Val 
    2030                 2035                 2040             


Gln Lys  Leu Ser Gln Ala Asp  Gly Ser Phe Leu Lys  Glu Lys Leu 
    2045                 2050                 2055             


Ala Gly  Leu Asn Gln Arg Trp  Asp Ala Ile Val Ala  Glu Val Lys 
    2060                 2065                 2070             


Asp Arg  Gln Pro Arg Leu Lys  Gly Glu Ser Lys Gln  Val Met Lys 
    2075                 2080                 2085             


Tyr Arg  His Gln Leu Asp Glu  Ile Ile Cys Trp Leu  Thr Lys Ala 
    2090                 2095                 2100             


Glu His  Ala Met Gln Lys Arg  Ser Thr Thr Glu Leu  Gly Glu Asn 
    2105                 2110                 2115             


Leu Gln  Glu Leu Arg Asp Leu  Thr Gln Glu Met Glu  Val His Ala 
    2120                 2125                 2130             


Glu Lys  Leu Lys Trp Leu Asn  Arg Thr Glu Leu Glu  Met Leu Ser 
    2135                 2140                 2145             


Asp Lys  Ser Leu Ser Leu Pro  Glu Arg Asp Lys Ile  Ser Glu Ser 
    2150                 2155                 2160             


Leu Arg  Thr Val Asn Met Thr  Trp Asn Lys Ile Cys  Arg Glu Val 
    2165                 2170                 2175             


Pro Thr  Thr Leu Lys Glu Cys  Ile Gln Glu Pro Ser  Ser Val Ser 
    2180                 2185                 2190             


Gln Thr  Arg Ile Ala Ala His  Pro Asn Val Gln Lys  Val Val Leu 
    2195                 2200                 2205             


Val Ser  Ser Ala Ser Asp Ile  Pro Val Gln Ser His  Arg Thr Ser 
    2210                 2215                 2220             


Glu Ile  Ser Ile Pro Ala Asp  Leu Asp Lys Thr Ile  Thr Glu Leu 
    2225                 2230                 2235             


Ala Asp  Trp Leu Val Leu Ile  Asp Gln Met Leu Lys  Ser Asn Ile 
    2240                 2245                 2250             


Val Thr  Val Gly Asp Val Glu  Glu Ile Asn Lys Thr  Val Ser Arg 
    2255                 2260                 2265             


Met Lys  Ile Thr Lys Ala Asp  Leu Glu Gln Arg His  Pro Gln Leu 
    2270                 2275                 2280             


Asp Tyr  Val Phe Thr Leu Ala  Gln Asn Leu Lys Asn  Lys Ala Ser 
    2285                 2290                 2295             


Ser Ser  Asp Met Arg Thr Ala  Ile Thr Glu Lys Leu  Glu Arg Val 
    2300                 2305                 2310             


Lys Asn  Gln Trp Asp Gly Thr  Gln His Gly Val Glu  Leu Arg Gln 
    2315                 2320                 2325             


Gln Gln  Leu Glu Asp Met Ile  Ile Asp Ser Leu Gln  Trp Asp Asp 
    2330                 2335                 2340             


His Arg  Glu Glu Thr Glu Glu  Leu Met Arg Lys Tyr  Glu Ala Arg 
    2345                 2350                 2355             


Leu Tyr  Ile Leu Gln Gln Ala  Arg Arg Asp Pro Leu  Thr Lys Gln 
    2360                 2365                 2370             


Ile Ser  Asp Asn Gln Ile Leu  Leu Gln Glu Leu Gly  Pro Gly Asp 
    2375                 2380                 2385             


Gly Ile  Val Met Ala Phe Asp  Asn Val Leu Gln Lys  Leu Leu Glu 
    2390                 2395                 2400             


Glu Tyr  Gly Ser Asp Asp Thr  Arg Asn Val Lys Glu  Thr Thr Glu 
    2405                 2410                 2415             


Tyr Leu  Lys Thr Ser Trp Ile  Asn Leu Lys Gln Ser  Ile Ala Asp 
    2420                 2425                 2430             


Arg Gln  Asn Ala Leu Glu Ala  Glu Trp Arg Thr Val  Gln Ala Ser 
    2435                 2440                 2445             


Arg Arg  Asp Leu Glu Asn Phe  Leu Lys Trp Ile Gln  Glu Ala Glu 
    2450                 2455                 2460             


Thr Thr  Val Asn Val Leu Val  Asp Ala Ser His Arg  Glu Asn Ala 
    2465                 2470                 2475             


Leu Gln  Asp Ser Ile Leu Ala  Arg Glu Leu Lys Gln  Gln Met Gln 
    2480                 2485                 2490             


Asp Ile  Gln Ala Glu Ile Asp  Ala His Asn Asp Ile  Phe Lys Ser 
    2495                 2500                 2505             


Ile Asp  Gly Asn Arg Gln Lys  Met Val Lys Ala Leu  Gly Asn Ser 
    2510                 2515                 2520             


Glu Glu  Ala Thr Met Leu Gln  His Arg Leu Asp Asp  Met Asn Gln 
    2525                 2530                 2535             


Arg Trp  Asn Asp Leu Lys Ala  Lys Ser Ala Ser Ile  Arg Ala His 
    2540                 2545                 2550             


Leu Glu  Ala Ser Ala Glu Lys  Trp Asn Arg Leu Leu  Met Ser Leu 
    2555                 2560                 2565             


Glu Glu  Leu Ile Lys Trp Leu  Asn Met Lys Asp Glu  Glu Leu Lys 
    2570                 2575                 2580             


Lys Gln  Met Pro Ile Gly Gly  Asp Val Pro Ala Leu  Gln Leu Gln 
    2585                 2590                 2595             


Tyr Asp  His Cys Lys Ala Leu  Arg Arg Glu Leu Lys  Glu Lys Glu 
    2600                 2605                 2610             


Tyr Ser  Val Leu Asn Ala Val  Asp Gln Ala Arg Val  Phe Leu Ala 
    2615                 2620                 2625             


Asp Gln  Pro Ile Glu Ala Pro  Glu Glu Pro Arg Arg  Asn Leu Gln 
    2630                 2635                 2640             


Ser Lys  Thr Glu Leu Thr Pro  Glu Glu Arg Ala Gln  Lys Ile Ala 
    2645                 2650                 2655             


Lys Ala  Met Arg Lys Gln Ser  Ser Glu Val Lys Glu  Lys Trp Glu 
    2660                 2665                 2670             


Ser Leu  Asn Ala Val Thr Ser  Asn Trp Gln Lys Gln  Val Asp Lys 
    2675                 2680                 2685             


Ala Leu  Glu Lys Leu Arg Asp  Leu Gln Gly Ala Met  Asp Asp Leu 
    2690                 2695                 2700             


Asp Ala  Asp Met Lys Glu Ala  Glu Ser Val Arg Asn  Gly Trp Lys 
    2705                 2710                 2715             


Pro Val  Gly Asp Leu Leu Ile  Asp Ser Leu Gln Asp  His Ile Glu 
    2720                 2725                 2730             


Lys Ile  Met Ala Phe Arg Glu  Glu Ile Ala Pro Ile  Asn Phe Lys 
    2735                 2740                 2745             


Val Lys  Thr Val Asn Asp Leu  Ser Ser Gln Leu Ser  Pro Leu Asp 
    2750                 2755                 2760             


Leu His  Pro Ser Leu Lys Met  Ser Arg Gln Leu Asp  Asp Leu Asn 
    2765                 2770                 2775             


Met Arg  Trp Lys Leu Leu Gln  Val Ser Val Asp Asp  Arg Leu Lys 
    2780                 2785                 2790             


Gln Leu  Gln Glu Ala His Arg  Asp Phe Gly Pro Ser  Ser Gln His 
    2795                 2800                 2805             


Phe Leu  Ser Thr Ser Val Gln  Leu Pro Trp Gln Arg  Ser Ile Ser 
    2810                 2815                 2820             


His Asn  Lys Val Pro Tyr Tyr  Ile Asn His Gln Thr  Gln Thr Thr 
    2825                 2830                 2835             


Cys Trp  Asp His Pro Lys Met  Thr Glu Leu Phe Gln  Ser Leu Ala 
    2840                 2845                 2850             


Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr Arg Thr  Ala Ile Lys 
    2855                 2860                 2865             


Ile Arg  Arg Leu Gln Lys Ala  Leu Cys Leu Asp Leu  Leu Glu Leu 
    2870                 2875                 2880             


Ser Thr  Thr Asn Glu Ile Phe  Lys Gln His Lys Leu  Asn Gln Asn 
    2885                 2890                 2895             


Asp Gln  Leu Leu Ser Val Pro  Asp Val Ile Asn Cys  Leu Thr Thr 
    2900                 2905                 2910             


Thr Tyr  Asp Gly Leu Glu Gln  Met His Lys Asp Leu  Val Asn Val 
    2915                 2920                 2925             


Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp Leu Leu  Asn Val Tyr 
    2930                 2935                 2940             


Asp Thr  Gly Arg Thr Gly Lys  Ile Arg Val Gln Ser  Leu Lys Ile 
    2945                 2950                 2955             


Gly Leu  Met Ser Leu Ser Lys  Gly Leu Leu Glu Glu  Lys Tyr Arg 
    2960                 2965                 2970             


Tyr Leu  Phe Lys Glu Val Ala  Gly Pro Thr Glu Met  Cys Asp Gln 
    2975                 2980                 2985             


Arg Gln  Leu Gly Leu Leu Leu  His Asp Ala Ile Gln  Ile Pro Arg 
    2990                 2995                 3000             


Gln Leu  Gly Glu Val Ala Ala  Phe Gly Gly Ser Asn  Ile Glu Pro 
    3005                 3010                 3015             


Ser Val  Arg Ser Cys Phe Gln  Gln Asn Asn Asn Lys  Pro Glu Ile 
    3020                 3025                 3030             


Ser Val  Lys Glu Phe Ile Asp  Trp Met His Leu Glu  Pro Gln Ser 
    3035                 3040                 3045             


Met Val  Trp Leu Pro Val Leu  His Arg Val Ala Ala  Ala Glu Thr 
    3050                 3055                 3060             


Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys Lys Glu  Cys Pro Ile 
    3065                 3070                 3075             


Val Gly  Phe Arg Tyr Arg Ser  Leu Lys His Phe Asn  Tyr Asp Val 
    3080                 3085                 3090             


Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Thr Ala Lys  Gly His Lys 
    3095                 3100                 3105             


Leu His  Tyr Pro Met Val Glu  Tyr Cys Ile Pro Thr  Thr Ser Gly 
    3110                 3115                 3120             


Glu Asp  Val Arg Asp Phe Thr  Lys Val Leu Lys Asn  Lys Phe Arg 
    3125                 3130                 3135             


Ser Lys  Lys Tyr Phe Ala Lys  His Pro Arg Leu Gly  Tyr Leu Pro 
    3140                 3145                 3150             


Val Gln  Thr Val Leu Glu Gly  Asp Asn Leu Glu Thr  Pro Ile Thr 
    3155                 3160                 3165             


Leu Ile  Ser Met Trp Pro Glu  His Tyr Asp Pro Ser  Gln Ser Pro 
    3170                 3175                 3180             


Gln Leu  Phe His Asp Asp Thr  His Ser Arg Ile Glu  Gln Tyr Ala 
    3185                 3190                 3195             


Thr Arg  Leu Ala Gln Met Glu  Arg Thr Asn Gly Ser  Phe Leu Thr 
    3200                 3205                 3210             


Asp Ser  Ser Ser Thr Thr Gly  Ser Val Glu Asp Glu  His Ala Leu 
    3215                 3220                 3225             


Ile Gln  Gln Tyr Cys Gln Thr  Leu Gly Gly Glu Ser  Pro Val Ser 
    3230                 3235                 3240             


Gln Pro  Gln Ser Pro Ala Gln  Ile Leu Lys Ser Val  Glu Arg Glu 
    3245                 3250                 3255             


Glu Arg  Gly Glu Leu Glu Arg  Ile Ile Ala Asp Leu  Glu Glu Glu 
    3260                 3265                 3270             


Gln Arg  Asn Leu Gln Val Glu  Tyr Glu Gln Leu Lys  Asp Gln His 
    3275                 3280                 3285             


Leu Arg  Arg Gly Leu Pro Val  Gly Ser Pro Pro Glu  Ser Ile Ile 
    3290                 3295                 3300             


Ser Pro  His His Thr Ser Glu  Asp Ser Glu Leu Ile  Ala Glu Ala 
    3305                 3310                 3315             


Lys Leu  Leu Arg Gln His Lys  Gly Arg Leu Glu Ala  Arg Met Gln 
    3320                 3325                 3330             


Ile Leu  Glu Asp His Asn Lys  Gln Leu Glu Ser Gln  Leu His Arg 
    3335                 3340                 3345             


Leu Arg  Gln Leu Leu Glu Gln  Pro Glu Ser Asp Ser  Arg Ile Asn 
    3350                 3355                 3360             


Gly Val  Ser Pro Trp Ala Ser  Pro Gln His Ser Ala  Leu Ser Tyr 
    3365                 3370                 3375             


Ser Leu  Asp Pro Asp Ala Ser  Gly Pro Gln Phe His  Gln Ala Ala 
    3380                 3385                 3390             


Gly Glu  Asp Leu Leu Ala Pro  Pro His Asp Thr Ser  Thr Asp Leu 
    3395                 3400                 3405             


Thr Glu  Val Met Glu Gln Ile  His Ser Thr Phe Pro  Ser Cys Cys 
    3410                 3415                 3420             


Pro Asn  Val Pro Ser Arg Pro  Gln Ala Met 
    3425                 3430             


<210>  186
<211>  119
<212>  PRT
<213>  Homo sapiens;

<400>  186

Met Val Lys Met Thr Lys Ser Lys Thr Phe Gln Ala Tyr Leu Pro Asn 
1               5                   10                  15      


Cys His Arg Thr Tyr Ser Cys Ile His Cys Arg Ala His Leu Ala Asn 
            20                  25                  30          


His Asp Glu Leu Ile Ser Lys Ser Phe Gln Gly Ser Gln Gly Arg Ala 
        35                  40                  45              


Tyr Leu Phe Asn Ser Val Val Asn Val Gly Cys Gly Pro Ala Glu Glu 
    50                  55                  60                  


Arg Val Leu Leu Thr Gly Leu His Ala Val Ala Asp Ile Tyr Cys Glu 
65                  70                  75                  80  


Asn Cys Lys Thr Thr Leu Gly Trp Lys Tyr Glu His Ala Phe Glu Ser 
                85                  90                  95      


Ser Gln Lys Tyr Lys Glu Gly Lys Phe Ile Ile Glu Leu Ala His Met 
            100                 105                 110         


Ile Lys Asp Asn Gly Trp Glu 
        115                 


<210>  187
<211>  494
<212>  PRT
<213>  Homo sapiens;

<400>  187

Met Ser Thr Thr Leu Leu Ser Ala Phe Tyr Asp Val Asp Phe Leu Cys 
1               5                   10                  15      


Lys Thr Glu Lys Ser Leu Ala Asn Leu Asn Leu Asn Asn Met Leu Asp 
            20                  25                  30          


Lys Lys Ala Val Gly Thr Pro Val Ala Ala Ala Pro Ser Ser Gly Phe 
        35                  40                  45              


Ala Pro Gly Phe Leu Arg Arg His Ser Ala Ser Asn Leu His Ala Leu 
    50                  55                  60                  


Ala His Pro Ala Pro Ser Pro Gly Ser Cys Ser Pro Lys Phe Pro Gly 
65                  70                  75                  80  


Ala Ala Asn Gly Ser Ser Cys Gly Ser Ala Ala Ala Gly Gly Pro Thr 
                85                  90                  95      


Ser Tyr Gly Thr Leu Lys Glu Pro Ser Gly Gly Gly Gly Thr Ala Leu 
            100                 105                 110         


Leu Asn Lys Glu Asn Lys Phe Arg Asp Arg Ser Phe Ser Glu Asn Gly 
        115                 120                 125             


Asp Arg Ser Gln His Leu Leu His Leu Gln Gln Gln Gln Lys Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Asn Ser Thr Arg Tyr Lys Thr Glu Leu Cys Arg 
145                 150                 155                 160 


Pro Phe Glu Glu Ser Gly Thr Cys Lys Tyr Gly Glu Lys Cys Gln Phe 
                165                 170                 175     


Ala His Gly Phe His Glu Leu Arg Ser Leu Thr Arg His Pro Lys Tyr 
            180                 185                 190         


Lys Thr Glu Leu Cys Arg Thr Phe His Thr Ile Gly Phe Cys Pro Tyr 
        195                 200                 205             


Gly Pro Arg Cys His Phe Ile His Asn Ala Asp Glu Arg Arg Pro Ala 
    210                 215                 220                 


Pro Ser Gly Gly Ala Ser Gly Asp Leu Arg Ala Phe Gly Thr Arg Asp 
225                 230                 235                 240 


Ala Leu His Leu Gly Phe Pro Arg Glu Pro Arg Pro Lys Leu His His 
                245                 250                 255     


Ser Leu Ser Phe Ser Gly Phe Pro Ser Gly His His Gln Pro Pro Gly 
            260                 265                 270         


Gly Leu Glu Ser Pro Leu Leu Leu Asp Ser Pro Thr Ser Arg Thr Pro 
        275                 280                 285             


Pro Pro Pro Ser Cys Ser Ser Ala Ser Ser Cys Ser Ser Ser Ala Ser 
    290                 295                 300                 


Ser Cys Ser Ser Ala Ser Ala Ala Ser Thr Pro Ser Gly Ala Pro Thr 
305                 310                 315                 320 


Cys Cys Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Tyr Gly 
                325                 330                 335     


Thr Gly Gly Ala Glu Asp Leu Leu Ala Pro Gly Ala Pro Cys Ala Ala 
            340                 345                 350         


Cys Ser Ser Ala Ser Cys Ala Asn Asn Ala Phe Ala Phe Gly Pro Glu 
        355                 360                 365             


Leu Ser Ser Leu Ile Thr Pro Leu Ala Ile Gln Thr His Asn Phe Ala 
    370                 375                 380                 


Ala Val Ala Ala Ala Ala Tyr Tyr Arg Ser Gln Gln Gln Gln Gln Gln 
385                 390                 395                 400 


Gln Gly Leu Ala Pro Pro Ala Gln Pro Pro Ala Pro Pro Ser Ala Thr 
                405                 410                 415     


Leu Pro Ala Gly Ala Ala Ala Pro Pro Ser Pro Pro Phe Ser Phe Gln 
            420                 425                 430         


Leu Pro Arg Arg Leu Ser Asp Ser Pro Val Phe Asp Ala Pro Pro Ser 
        435                 440                 445             


Pro Pro Asp Ser Leu Ser Asp Arg Asp Ser Tyr Leu Ser Gly Ser Leu 
    450                 455                 460                 


Ser Ser Gly Ser Leu Ser Gly Ser Glu Ser Pro Ser Leu Asp Pro Gly 
465                 470                 475                 480 


Arg Arg Leu Pro Ile Phe Ser Arg Leu Ser Ile Ser Asp Asp 
                485                 490                 


<210>  188
<211>  837
<212>  PRT
<213>  Homo sapiens;

<400>  188

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr Thr Ser Gly Pro Gly Thr Gly Asp Ser Asp 
                165                 170                 175     


Ser Gly Ile Ser Val Ser Lys Thr Pro Ile Met Lys Pro Gly Lys Pro 
            180                 185                 190         


Lys Ala Asp Ala Lys Lys Val Pro Lys Lys Pro Glu Glu Ile Thr Pro 
        195                 200                 205             


Glu Asn His Val Glu Gly Thr Ala Arg Leu Val Thr Asp Thr Ala Glu 
    210                 215                 220                 


Ile Leu Ser Arg Leu Gly Gly Val Glu Leu Leu Gln Asp Thr Leu Gly 
225                 230                 235                 240 


His Val Met Pro Ser Val Gln Leu Pro Pro Asn Ile Asn Leu Val Pro 
                245                 250                 255     


Lys Val Pro Val Pro Leu Asn Thr Thr Lys Tyr Asn Ser Ala Leu Asp 
            260                 265                 270         


Thr Asn Ala Thr Met Ile Asn Ser Phe Asn Lys Phe Pro Tyr Pro Thr 
        275                 280                 285             


Gln Ala Glu Leu Ser Trp Leu Thr Ala Ala Ser Lys His Pro Glu Glu 
    290                 295                 300                 


His Ile Arg Ile Trp Phe Ala Thr Gln Arg Leu Lys His Gly Ile Ser 
305                 310                 315                 320 


Trp Ser Pro Glu Glu Val Glu Glu Ala Arg Lys Lys Met Phe Asn Gly 
                325                 330                 335     


Thr Ile Gln Ser Val Pro Pro Thr Ile Thr Val Leu Pro Ala Gln Leu 
            340                 345                 350         


Ala Pro Thr Lys Val Thr Gln Pro Ile Leu Gln Thr Ala Leu Pro Cys 
        355                 360                 365             


Gln Ile Leu Gly Gln Thr Ser Leu Val Leu Thr Gln Val Thr Ser Gly 
    370                 375                 380                 


Ser Thr Thr Val Ser Cys Ser Pro Ile Thr Leu Ala Val Ala Gly Val 
385                 390                 395                 400 


Thr Asn His Gly Gln Lys Arg Pro Leu Val Thr Pro Gln Ala Ala Pro 
                405                 410                 415     


Glu Pro Lys Arg Pro His Ile Ala Gln Val Pro Glu Pro Pro Pro Lys 
            420                 425                 430         


Val Ala Asn Pro Pro Leu Thr Pro Ala Ser Asp Arg Lys Lys Thr Lys 
        435                 440                 445             


Glu Gln Ile Ala His Leu Lys Ala Ser Phe Leu Gln Ser Gln Phe Pro 
    450                 455                 460                 


Asp Asp Ala Glu Val Tyr Arg Leu Ile Glu Val Thr Gly Leu Ala Arg 
465                 470                 475                 480 


Ser Glu Ile Lys Lys Trp Phe Ser Asp His Arg Tyr Arg Cys Gln Arg 
                485                 490                 495     


Gly Ile Val His Ile Thr Ser Glu Ser Leu Ala Lys Asp Gln Leu Ala 
            500                 505                 510         


Ile Ala Ala Ser Arg His Gly Arg Thr Tyr His Ala Tyr Pro Asp Phe 
        515                 520                 525             


Ala Pro Gln Lys Phe Lys Glu Lys Thr Gln Gly Gln Val Lys Ile Leu 
    530                 535                 540                 


Glu Asp Ser Phe Leu Lys Ser Ser Phe Pro Thr Gln Ala Glu Leu Asp 
545                 550                 555                 560 


Arg Leu Arg Val Glu Thr Lys Leu Ser Arg Arg Glu Ile Asp Ser Trp 
                565                 570                 575     


Phe Ser Glu Arg Arg Lys Leu Arg Asp Ser Met Glu Gln Ala Val Leu 
            580                 585                 590         


Asp Ser Met Gly Ser Gly Lys Lys Gly Gln Asp Val Gly Ala Pro Asn 
        595                 600                 605             


Gly Ala Leu Ser Arg Leu Asp Gln Leu Ser Gly Ala Gln Leu Thr Ser 
    610                 615                 620                 


Ser Leu Pro Ser Pro Ser Pro Ala Ile Ala Lys Ser Gln Glu Gln Val 
625                 630                 635                 640 


His Leu Leu Arg Ser Thr Phe Ala Arg Thr Gln Trp Pro Thr Pro Gln 
                645                 650                 655     


Glu Tyr Asp Gln Leu Ala Ala Lys Thr Gly Leu Val Arg Thr Glu Ile 
            660                 665                 670         


Val Arg Trp Phe Lys Glu Asn Arg Cys Leu Leu Lys Thr Gly Thr Val 
        675                 680                 685             


Lys Trp Met Glu Gln Tyr Gln His Gln Pro Met Ala Asp Asp His Gly 
    690                 695                 700                 


Tyr Asp Ala Val Ala Arg Lys Ala Thr Lys Pro Met Ala Glu Ser Pro 
705                 710                 715                 720 


Lys Asn Gly Gly Asp Val Val Pro Gln Tyr Tyr Lys Asp Pro Lys Lys 
                725                 730                 735     


Leu Cys Glu Glu Asp Leu Glu Lys Leu Val Thr Arg Val Lys Val Gly 
            740                 745                 750         


Ser Glu Pro Ala Lys Asp Cys Leu Pro Ala Lys Pro Ser Glu Ala Thr 
        755                 760                 765             


Ser Asp Arg Ser Glu Gly Ser Ser Arg Asp Gly Gln Gly Ser Asp Glu 
    770                 775                 780                 


Asn Glu Glu Ser Ser Val Val Asp Tyr Val Glu Val Thr Val Gly Glu 
785                 790                 795                 800 


Glu Asp Ala Ile Ser Asp Arg Ser Asp Ser Trp Ser Gln Ala Ala Ala 
                805                 810                 815     


Glu Gly Val Ser Glu Leu Ala Glu Ser Asp Ser Asp Cys Val Pro Ala 
            820                 825                 830         


Glu Ala Gly Gln Ala 
        835         


<210>  189
<211>  1503
<212>  DNA
<213>  Homo sapiens;

<400>  189
atggcctcca tgttgctcgc ccagcgcctg gcctgcagct tccagcacag ctaccgcctg       60

ctggtgcctg gatccagaca cattagtcaa gctgcagcca aagtcgacgt tgaatttgat      120

tatgatgggc ctctgatgaa gacggaagtc ccagggccta gatctcagga gttaatgaaa      180

cagctgaata taattcagaa tgcagaggct gtgcattttt tctgcaatta cgaagagagc      240

cgaggcaatt acctggttga tgtggacggc aaccgaatgc tggatcttta ttcccagatc      300

tcctctgtcc ccataggtta cagccacccc gccctgctga aactcatcca acagcctcaa      360

aatgcgagca tgtttgtcaa cagacccgcc ctcggaatcc tgcctccgga gaactttgtg      420

gagaagctcc ggcagtcctt gctctcggtg gctcccaaag ggatgtccca gctcatcacc      480

atggcctgcg gctcctgctc caatgaaaac gccttaaaga ccatcttcat gtggtaccgg      540

agcaaggaaa gagggcagag gggcttctcc caggaggagc tggagacgtg catgattaac      600

caggcccctg gctgccccga ctacagcatc ctctccttca tgggcgcgtt ccatgggagg      660

accatgggtt gcttagcgac cacgcactct aaagccattc acaagatcga catcccttcc      720

tttgactggc ccatcgcacc gttcccacgg ctgaaatacc ctctggaaga gtttgtgaaa      780

gagaaccaac aggaggaggc ccgctgtctg gaagaggtgg aggatctgat tgtgaaatat      840

cggaaaaaga agaagacggt ggccgggatc atcgtggagc ccatccagtc cgagggtgga      900

gacaaccacg catccgatga cttctttcgg aagctgagag acatcgccag gaagcatggc      960

tgcgccttct tggtggacga ggtccagacc ggaggaggct gcacgggcaa gttctgggcc     1020

catgagcact ggggcctgga tgacccagca gacgtgatga ccttcagcaa gaagatgatg     1080

actgggggct tcttccacaa ggaggagttc aggcctaatg ctccctaccg gatcttcaac     1140

acctggctgg gggacccgtc caagaacctg ttgctggctg aggtcatcaa catcatcaag     1200

cgggaggacc tgctaaataa tgcagcccat gccgggaagg ccctgctcac aggactgctg     1260

gacctccagg cccggtaccc ccagttcatc agcagggtga gaggacgagg caccttttgc     1320

tccttcgata ctcccgatga ttccatacgg aataagctca ttttaattgc cagaaacaaa     1380

ggtgtggtgt tgggtggctg tggtgacaaa tccattcgtt tccgtcccac gctggtcttc     1440

agggatcacc acgctcacct gttcctcaat attttcagtg acatcttagc agacttcaag     1500

taa                                                                   1503


<210>  190
<211>  1278
<212>  DNA
<213>  Homo sapiens;

<400>  190
atgaatgcca tgctggagac tcccgaactc ccagccgtgt ttgatggagt gaagctggct       60

gcagtggctg ctgtgctgta cgtgatcgtc cggtgtttga acctgaagag ccccacagcc      120

ccacctgacc tctacttcca ggactcgggg ctctcacgct ttctgctcaa gtcctgtcct      180

cttctgacca aagaatacat tccaccgttg atctggggga aaagtggaca catccagaca      240

gccttgtatg ggaagatggg aagggtgagg tcgccacatc cttatgggca ccggaagttc      300

atcactatgt ctgatggagc cacttctaca ttcgacctct tcgagccctt ggctgagcac      360

tgtgttggag atgatatcac catggtcatc tgccctggaa ttgccaatca cagcgagaag      420

caatacatcc gcactttcgt tgactacgcc cagaaaaatg gctatcggtg cgccgtgctg      480

aaccacctgg gtgccctgcc caacattgaa ttgacctcgc cacgcatgtt cacctatggc      540

tgcacgtggg aatttggagc catggtgaac tacatcaaga agacatatcc cctgacccag      600

ctggtcgtcg tgggcttcag cctgggtggt aacattgtgt gcaaatactt gggggagact      660

caggcaaacc aagagaaggt cctgtgctgc gtcagcgtgt gccaggggta cagtgcactg      720

agggcccagg aaaccttcat gcaatgggat cagtgccggc ggttctacaa cttcctcatg      780

gctgacaaca tgaagaagat catcctctcg cacaggcaag ctctttttgg agaccatgtt      840

aagaaacccc agagcctgga agacacggac ttgagccggc tctacacagc aacatccctg      900

atgcagattg atgacaatgt gatgaggaag tttcacggct ataactccct gaaggaatac      960

tatgaggaag aaagttgcat gcggtacctg cacaggattt atgttcctct catgctggtt     1020

aatgcagctg acgatccgtt ggtgcatgaa agtcttctaa ccattccaaa atctctttca     1080

gagaaacgag agaacgtcat gtttgtgctg cctctgcatg ggggccactt gggcttcttt     1140

gagggctctg tgctgttccc cgagcccctg acatggatgg ataagctggt ggtggagtac     1200

gccaacgcca tttgccaatg ggagcgtaac aagttgcagt gctctgacac ggagcaggtg     1260

gaggccgacc tggagtga                                                   1278


<210>  191
<211>  1527
<212>  DNA
<213>  Homo sapiens;

<400>  191
atggcagagc tgcagatgtt actagaggag gagatcccgt ctggcaagag ggcgctgatc       60

gagagttacc agaacctgac tcgggtggca gactactgtg aaaacaacta catacaggct      120

acagacaaga gaaaagcttt agaggagacc aaagcctata caacccaatc tctagctagt      180

gttgcttatc aaataaatgc attggccaac aatgtactcc agttgctgga tatccaagcc      240

tctcagcttc ggagaatgga gtcttccatc aatcatatct cacagactgt ggatattcat      300

aaggagaaag tggcacgaag agagattggt attttgacaa caaataagaa tacatcaaga      360

actcacaaaa taatagcacc tgcgaatatg gagcgccctg taaggtatat tcggaaacct      420

atcgattaca cagttctgga tgatgtgggc catggtgtca agtggctaaa agccaagcat      480

ggaaataacc agcctgcaag aactggcaca ctgtcgagaa caaatcctcc tactcagaaa      540

ccgccaagtc ctcccatgtc aggccgggga acactgggac ggaatactcc ttataaaacc      600

ctggaacctg ttaaaccccc aacagttcct aatgactata tgaccagtcc tgctaggctt      660

ggaagtcagc atagtccagg caggacagca tctttaaatc agagaccaag gacacacagt      720

ggaagtagtg gaggaagtgg aagtcgagaa aacagtggta gcagtagtat tggcattccc      780

attgctgtgc ctacaccttc gccacccact attggaccag aaaacatttc tgtccctcct      840

ccttctggag ctccaccagc accacctctg gcaccacttc tcccagtgag cactgtgata      900

gcagccccgg gctcagctcc tggttcccag tatggcacaa tgaccaggca gatatctcga      960

cacaactcta ctacttcttc gacatcttct ggtggataca gacgaactcc ctctgtgact     1020

gctcaatttt ctgctcagcc tcatgttaat ggaggtccac tttattctca aaattcaatt     1080

tctattgctc caccccctcc ccctatgcct cagttgactc cacagatacc tctcacaggc     1140

ttcgtggcca gggtgcagga aaacattgct gatagtccaa ctccaccgcc accacctcca     1200

ccagatgaca ttcccatgtt tgatgactct ccacctcccc caccaccacc accagtggat     1260

tatgaagatg aggaggctgc agtagttcag tataatgatc catatgcaga tggggatcct     1320

gcttgggccc ccaagaatta tattgagaaa gttgttgcaa tatatgatta tacaaaagac     1380

aaggatgatg agctgtcatt tatggagggt gcaatcattt atgttataaa gaagaatgat     1440

gatggctggt atgaaggagt ctgcaatcga gtgactggtc tgttccctgg gaactatgtt     1500

gaatcaatca tgcactatac tgattaa                                         1527


<210>  192
<211>  2337
<212>  DNA
<213>  Homo sapiens;

<400>  192
atgcctgcct tccttggtct aaagtgtctg gggaaattgt gcagctctga gaaaagcaaa       60

gtcacctcat ctgagagaac cagtgccagg ggctcgaaca gaaagagact gattgttgag      120

gaccggaggg tctctgggac ctccttcacc gctcataggc gtgccactat cactcatttg      180

ctgtatctct gtcccaagga ctactgccca cgtgggcgtg tatgtaacag cgttgatcct      240

tttgtggccc accctcagga ccctcaccac ccatcagaga agcctgtcat tcactgccat      300

aaatgtgggg agccttgcaa gggtgaagtg cttcgggtcc agaccaaaca tttccacatc      360

aagtgtttca cctgcaaagt gtgtggctgt gacctggcac aagggggctt cttcataaag      420

aacggagagt atctctgcac cctggactac cagcggatgt acgggacacg ctgccatggc      480

tgtggggagt tcgtggaggg cgaagtggtg actgctctgg gcaagaccta ccatcccaat      540

tgctttgctt gtactatctg caagcgcccg tttccacccg gagaccgagt cacattcaat      600

gggagagact gcctttgtca actctgtgca cagccgatgt cgtccagtcc gaaagaaacc      660

accttctcca gcaattgtgc cggctgcgga agagatatca agaatgggca ggcgctgctg      720

gcgctggata agcagtggca cttggggtgc tttaaatgca agtcctgcgg gaaggtcctc      780

accggggagt acatcagcaa ggatggtgct ccgtactgtg aaaaggacta ccagggactc      840

tttggggtga aatgtgaggc gtgtcaccag tttatcacag ggaaagtcct ggaggcaggt      900

gacaaacatt accaccccag ctgtgcacga tgcagcagat gcaaccagat gttcacagaa      960

ggagaggaaa tgtatcttca aggctccacc gtttggcatc ccgactgtaa gcaatctacg     1020

aagaccgagg aaaagctgcg gcctaccagg acatcctcgg aaagtattta ttctaggcca     1080

ggctccagta ttcctggctc accaggtcat actatctatg caaaagtaga caatgagatc     1140

ctggattaca aggatttagc agccattccg aaggtcaagg caatttatga cattgaacgt     1200

ccagatctta ttacctatga gcctttctac acttcgggct atgatgacaa acaggagaga     1260

cagagccttg gagagtctcc gaggactttg tctcctactc catcagcaga agggtaccag     1320

gatgttcggg atcggatgat ccatcggtcc acgagccagg gctccatcaa ctcccctgtg     1380

tacagccgcc acagctacac tccaaccacg tcccgctctc cccagcattt ccacagacct     1440

ggcaatgagc cgtccagcgg ccggaactcc cctctccctt accggccaga cagccgccct     1500

ctaactccaa cttacgctca ggcccctaaa catttccatg ttccagatca aggaatcaac     1560

atttaccgaa agccacccat ctacaaacag catgctgcct tggcagccca gagcaagtcc     1620

tcagaagata tcatcaagtt ttccaagttc ccagcagccc aggcaccaga ccccagcgag     1680

acaccaaaga ttgagacgga ccactggcct ggtcccccct catttgctgt cgtaggacct     1740

gacatgaaac gcagatctag tggcagagag gaagatgatg aggaacttct gagacgtcgg     1800

cagcttcaag aagagcaatt aatgaagctt aactcaggcc tgggacagtt gatcttgaaa     1860

gaagagatgg agaaagagag ccgggaaagg tcatctctgt tagccagtcg ctacgattct     1920

cccatcaact cagcttcaca tattccatca tctaaaactg catctctccc tggctatgga     1980

agaaatgggc ttcaccggcc tgtttctacc gacttcgctc agtataacag ctatggggat     2040

gtcagcgggg gagtgcgaga ttaccagaca ctcccagatg gccacatgcc tgcaatgaga     2100

atggaccgag gagtgtctat gcccaacatg ttggaaccaa agatatttcc atatgaaatg     2160

ctcatggtga ccaacagagg gcgaaacaaa atcctcagag aggtggacag aaccaggctg     2220

gagcgccact tagcccctga agtgtttcgg gaaatctttg gaatgtccat acaggagttt     2280

gacaggttac ctctttggag acgcaacgac atgaagaaaa aagcaaaact cttctaa        2337


<210>  193
<211>  1275
<212>  DNA
<213>  Homo sapiens;

<400>  193
atgcagaggc tgcaggtagt gctgggccac ctgaggggtc cggccgattc cggctggatg       60

ccgcaggccg cgccttgcct gagcggtgcc ccgcaggcct cggccgcgga cgtggtggtg      120

gtgcacgggc ggcgcacggc catctgccgg gcgggccgcg gcggcttcaa ggacaccacc      180

cccgacgagc ttctctcggc agtcatgacc gcggttctca aggacgtgaa tctgaggccg      240

gaacagctgg gggacatctg tgtcggaaat gtgctgcagc ctggggccgg ggcaatcatg      300

gcccgaatcg cccagtttct gagtgacatc ccggagactg tgcctttgtc cactgtcaat      360

agacagtgtt cgtcggggct acaggcagtg gccagcatag caggtggcat cagaaatggg      420

tcttatgaca ttggcatggc ctgtggggtg gagtccatgt ccctggctga cagagggaac      480

cctggaaata ttacttcgcg cttgatggag aaggagaagg ccagagattg cctgattcct      540

atggggataa cctctgagaa tgtggctgag cggtttggca tttcacggga gaagcaggat      600

acctttgccc tggcttccca gcagaaggca gcaagagccc agagcaaggg ctgtttccaa      660

gctgagattg tgcctgtgac caccacggtc catgatgaca agggcaccaa gaggagcatc      720

actgtgaccc aggatgaggg tatccgcccc agcaccacca tggagggcct ggccaaactg      780

aagcctgcct tcaagaaaga tggttctacc acagctggaa actctagcca ggtgagtgat      840

ggggcagctg ccatcctgct ggcccggagg tccaaggcag aagagttggg ccttcccatc      900

cttggggtcc tgaggtctta tgcagtggtt ggggtcccac ctgacatcat gggcattgga      960

cctgcctatg ccatcccagt agctttgcaa aaagcagggc tgacagtgag tgacgtggac     1020

atcttcgaga tcaatgaggc ctttgcaagc caggctgcct actgtgtgga gaagctacga     1080

ctcccccctg agaaggtgaa ccccctgggg ggtgcagtgg ccttagggca cccactgggc     1140

tgcactgggg cacgacaggt catcacgctg ctcaatgagc tgaagcgccg tgggaagagg     1200

gcatacggag tggtgtccat gtgcatcggg actggaatgg gagccgctgc cgtctttgaa     1260

taccctggga actga                                                      1275


<210>  194
<211>  2337
<212>  DNA
<213>  Homo sapiens;

<400>  194
atgaagatga ctgtggattt cgaggagtgt ctgaaggact cgccccgctt cagggcagct       60

ttggaagaag tagaaggtga tgtggcagaa ttggaactaa aacttgataa gcttgtgaaa      120

ctttgtattg caatgattga tactggaaaa gccttttgtg ttgcaaataa acagttcatg      180

aatgggattc gagacctggc tcagtattct agtaatgatg ctgtcgttga gacaagtttg      240

accaagtttt ctgacagtct tcaagaaatg ataaattttc acacaatcct gtttgaccaa      300

actcagagat caattaaggc acagcttcag aactttgtta aagaagatct tagaaaattc      360

aaagatgcca agaagcaatt cgaaaaagtc agtgaagaaa aagaaaatgc gttagtaaaa      420

aatgcccaag tacaaagaaa caaacaacat gaagttgaag aagccaccaa cattctgaca      480

gcaacaagaa aatgtttccg acacatagcc ctcgattatg tgcttcagat taatgttctt      540

caatcaaaaa ggagatcaga aatcctaaaa tcaatgttgt catttatgta tgcccatttg      600

gccttctttc atcaaggata tgatctgttt agtgaacttg gaccctacat gaaggatctt      660

ggtgcacagt tggatcgact ggttgtggat gcagcaaagg agaaaagaga aatggagcaa      720

aaacattcca ccattcaaca aaaggatttc tccagtgatg attctaagtt agaatataac      780

gtagatgctg caaatggcat agttatggaa ggatatctgt tcaaacgagc cagcaatgcc      840

ttcaaaactt ggaacaggcg ctggttttca atacagaata atcagttggt ttaccagaaa      900

aaatttaagg ataatccgac tgtggtagtt gaagacctca ggctttgcac agtgaaacat      960

tgtgaagaca tagagcgacg attctgcttt gaggtggtct cgccaacaaa aagttgcatg     1020

ctccaggcag attccgaaaa gctgcgccag gcatggatta aggctgttca gaccagtatt     1080

gctactgctt atagagagaa gggtgatgaa tcagagaagc tggataagaa atcatctcca     1140

tccacaggaa gcctagattc tggaaatgag tccaaagaga aattattgaa aggagaaagt     1200

gcgcttcagc gggtccagtg tatccctggc aatgccagct gttgtgactg tggcctggca     1260

gatccacggt gggccagcat caacctgggc atcaccttgt gtatcgagtg ctccggaatt     1320

caccggagcc ttggggttca tttttcaaaa gtacgatctt taactttaga cacctgggag     1380

ccagaacttt taaagcttat gtgtgagttg gggaatgatg ttataaatcg agtttatgaa     1440

gctaatgtgg aaaaaatggg aataaagaaa ccccaaccag gacaaagaca ggagaaggag     1500

gcatatatca gagcaaaata tgtggagagg aaatttgtgg ataaatattc tatatcatta     1560

tcacctcctg agcagcaaaa aaagtttgtc tctaaaagtt ctgaagaaaa gaggctgagc     1620

atttctaaat ttgggccagg ggaccaagtc agagcatctg cccaaagttc agtcagaagt     1680

aatgacagtg gaattcagca gagctctgat gatggaagag aatctttacc ctccacggtg     1740

tcagccaata gtttatatga gcctgaagga gaaaggcaag attcttctat gtttcttgac     1800

tcgaaacatc ttaatccagg acttcagctt tatagggcgt catatgaaaa aaaccttcct     1860

aaaatggctg aggctttggc tcatggtgca gacgtgaact gggccaattc agaggaaaac     1920

aaagcgacac cacttattca ggctgtatta gggggctctt tggtgacgtg tgagttcctc     1980

ctacagaatg gtgctaatgt caaccaaaga gatgtccaag ggcggggacc attgcaccat     2040

gccaccgtct tagggcacac agggcaggta tgtttattcc taaaacgagg tgccaatcaa     2100

catgccactg atgaagaagg gaaagaccct ttgagcatag ctgtggaagc agccaatgct     2160

gatatagtca ccttgttacg tttagcaaga atgaatgaag agatgcggga atcagaagga     2220

ctttatggac agccaggtga tgaaacttat caggacatat ttcgtgattt ttcccaaatg     2280

gcatccaata atccagagaa actaaatcgt ttccagcaag attcacagaa attctga        2337


<210>  195
<211>  1518
<212>  DNA
<213>  Homo sapiens;

<400>  195
atggcggagt cggccggagc ctcctccttc ttcccccttg ttgtcctcct gctcgccggc       60

agcggcgggt ccgggccccg gggggtccag gctctgctgt gtgcgtgcac cagctgcctc      120

caggccaact acacgtgtga gacagatggg gcctgcatgg tttccatttt caatctggat      180

gggatggagc accatgtgcg cacctgcatc cccaaagtgg agctggtccc tgccgggaag      240

cccttctact gcctgagctc ggaggacctg cgcaacaccc actgctgcta cactgactac      300

tgcaacagga tcgacttgag ggtgcccagt ggtcacctca aggagcctga gcacccgtcc      360

atgtggggcc cggtggagct ggtaggcatc atcgccggcc cggtgttcct cctgttcctc      420

atcatcatca ttgttttcct tgtcattaac tatcatcagc gtgtctatca caaccgccag      480

agactggaca tggaagatcc ctcatgtgag atgtgtctct ccaaagacaa gacgctccag      540

gatcttgtct acgatctctc cacctcaggg tctggctcag ggttacccct ctttgtccag      600

cgcacagtgg cccgaaccat cgttttacaa gagattattg gcaagggtcg gtttggggaa      660

gtatggcggg gccgctggag gggtggtgat gtggctgtga aaatattctc ttctcgtgaa      720

gaacggtctt ggttcaggga agcagagata taccagacgg tcatgctgcg ccatgaaaac      780

atccttggat ttattgctgc tgacaataaa gataatggca cctggacaca gctgtggctt      840

gtttctgact atcatgagca cgggtccctg tttgattatc tgaaccggta cacagtgaca      900

attgagggga tgattaagct ggccttgtct gctgctagtg ggctggcaca cctgcacatg      960

gagatcgtgg gcacccaagg gaagcctgga attgctcatc gagacttaaa gtcaaagaac     1020

attctggtga agaaaaatgg catgtgtgcc atagcagacc tgggcctggc tgtccgtcat     1080

gatgcagtca ctgacaccat tgacattgcc ccgaatcaga gggtggggac caaacgatac     1140

atggcccctg aagtacttga tgaaaccatt aatatgaaac actttgactc ctttaaatgt     1200

gctgatattt atgccctcgg gcttgtatat tgggagattg ctcgaagatg caattctgga     1260

ggagtccatg aagaatatca gctgccatat tacgacttag tgccctctga cccttccatt     1320

gaggaaatgc gaaaggttgt atgtgatcag aagctgcgtc ccaacatccc caactggtgg     1380

cagagttatg aggcactgcg ggtgatgggg aagatgatgc gagagtgttg gtatgccaac     1440

ggcgcagccc gcctgacggc cctgcgcatc aagaagaccc tctcccagct cagcgtgcag     1500

gaagacgtga agatctaa                                                   1518


<210>  196
<211>  444
<212>  DNA
<213>  Homo sapiens;

<400>  196
atgagccaaa ccagggattt acagggagga aaagctttcg gactgctgaa ggcccagcag       60

gaagagaggc tggatgagat caacaagcaa ttcctagacg atcccaaata tagcagtgat      120

gaggatctgc cctccaaact ggaaggcttc aaagagaaat acatggagtt tgaccttaat      180

ggaaatggcg atattgatat catgtccctg aaacgaatgc tggagaaact tggagtcccc      240

aagactcacc tagagctaaa gaaattaatt ggagaggtgt ccagtggctc cggggagacg      300

ttcagctacc ctgactttct caggatgatg ctgggcaaga gatctgccat cctaaaaatg      360

atcctgatgt atgaggaaaa agcgagagaa aaggaaaagc caacaggccc cccagccaag      420

aaagctatct ctgagttgcc ctga                                             444


<210>  197
<211>  1458
<212>  DNA
<213>  Homo sapiens;

<400>  197
atggagctcg aagtccggcg ggtccgacag gcgttcctgt ccggccggtc gcgacctctg       60

cggtttcggc tgcagcagct ggaggccctg cggaggatgg tgcaggagcg cgagaaggat      120

atcctgacgg ccatcgccgc cgacctgtgc aagagtgaat tcaatgtgta cagtcaggaa      180

gtcattactg tccttgggga aattgatttt atgcttgaga atcttcctga atgggttact      240

gctaaaccag ttaagaagaa cgtgctcacc atgctggatg aggcctatat tcagccacag      300

cctctgggag tggtgctgat aatcggagct tggaattacc ccttcgttct caccattcag      360

ccactgatag gagccatcgc tgcaggaaat gctgtgatta taaagccttc tgaactgagt      420

gaaaatacag ccaagatctt ggcaaagctt ctccctcagt atttagacca ggatctctat      480

attgttatta atggtggtgt tgaggaaacc acggagctcc tgaagcagcg atttgaccac      540

attttctata cgggaaacac tgcggttggc aaaattgtca tggaagctgc tgccaagcat      600

ctgacccctg tgactcttga actgggaggg aaaagtccat gttatattga taaagattgt      660

gacctggaca ttgtttgcag acgcataacc tggggaaaat acatgaattg tggccaaacc      720

tgcattgcac ccgactatat tctctgtgaa gcatccctcc aaaatcaaat tgtatggaag      780

attaaggaaa cagtgaagga attttatgga gaaaatataa aagagtctcc tgattatgaa      840

aggatcatca atcttcgtca ttttaagagg atactaagtt tgcttgaagg acaaaagata      900

gcttttggtg gggagactga tgaggccaca cgctacatag ccccaacagt acttaccgat      960

gttgatccta aaaccaaggt gatgcaagaa gaaatttttg gaccaattct tccaatagtg     1020

cctgtgaaaa atgtagatga ggccataaat ttcataaatg aacgtgaaaa gcctctggct     1080

ctttatgtat tttcgcataa ccataagctc atcaaacgga tgattgatga gacatccagt     1140

ggaggtgtca caggcaatga cgtcattatg cacttcacgc tcaactcttt cccatttgga     1200

ggagtgggtt ccagtgggat gggagcttat cacggaaaac atagttttga tactttttct     1260

catcagcgtc cctgtttatt aaaaagttta aagagagaag gtgctaacaa actcagatat     1320

cctcccaaca gccagtcaaa ggtggattgg ggaaaatttt ttctcttgaa acggttcaac     1380

aaagaaaaac tcggtctcct gttgctcact ttcctgggta ttgtagccgc tgtgcttgtc     1440

aaggcagaat attactga                                                   1458


<210>  198
<211>  720
<212>  DNA
<213>  Homo sapiens;

<400>  198
atggaaaaag aaaaaggaaa tgatgatgga ataccagacc aagagaattc cttggatttt       60

tctgaacact ttaaccaact tgaattgttg gaaacacatg gacaccttat tcctactggt      120

actcaaagtc tttgggtagg caattctgat gaagatgagg agcaagatga caaaaatgaa      180

gagtggtatc gattgcaaga aaaaaaaatg gaaaaagacc caagcagatt gcttctttgg      240

gctgctgaaa aaaatcggct taccacagtg cggagactcc tttctgaaaa ggccactcac      300

gtgaacacta gggatgaaga tgagtatacc cctcttcatc gagcagccta cagtggacac      360

ttagatattg ttcaggagct cattgcacag ggggccgatg ttcatgcagt gactgtggat      420

ggctggacgc ccctgcacag tgcttgtaag tggaataata ccagagtggc ttctttctta      480

ctgcagcatg atgcagatat caatgcccaa acaaaaggcc tcttgacccc cttgcatctt      540

gctgctggga acagagacag caaggatacc ctagaactcc tcctgatgaa ccgttacgtc      600

aaaccagggc tgaaaaacaa cttggaagaa actgcatttg atattgccag gaggacaagt      660

atctatcact acctctttga aattgtggaa ggctgtacaa attcttcacc tcagtcttaa      720


<210>  199
<211>  1728
<212>  DNA
<213>  Homo sapiens;

<400>  199
atgcagtccc cctggaaaat ccttacggtg gcgcctctat tcttgctcct gtctcttcag       60

tcctcggcct ctccagccaa cgatgaccag tccaggccca gcctctcgaa tgggcacacc      120

tgtgtagggt gtgtgctggt ggtgtctgta atagaacagc ttgctcaagt tcacaactcg      180

acggtccagg cctcgatgga gagactgtgc agctacctgc ctgaaaaact gttcttgaaa      240

accacctgct atttagtcat tgacaagttt ggatcagaca tcataaaact gcttagcgca      300

gatatgaatg ctgatgtggt atgtcacact ctggagtttt gtaaacagaa cactggccaa      360

ccattgtgtc atctctaccc tcttcccaag gagacatgga aatttacact acagaaggca      420

agacaaattg tcaagaagtc cccgattctg aaatattcta gaagtggttc tgacatttgt      480

tcactcccgg ttttggccaa gatctgccag aaaattaaat tagctatgga acagtctgtg      540

ccattcaaag atgtggattc agacaaatac agcgttttcc caacactgcg gggctatcac      600

tggcggggga gagactgtaa tgacagcgac gagtcagtgt acccaggtag aaggccgaac      660

aactgggatg tccatcagga ttcaaactgt aatggcattt ggggtgtcga tccaaaagat      720

ggagttccat atgagaagaa attctgtgaa ggttcacagc ccaggggaat cattttgctg      780

ggagactcag ctggggctca ttttcacatc tctcctgaat ggatcacagc gtcgcagatg      840

tctttgaact ctttcatcaa tctaccaaca gcccttacca acgagcttga ctggccccaa      900

ctctctggtg ctacaggatt tctggactcc actgttggaa ttaaagaaaa atctatttac      960

cttcgcttat ggaaaagaaa ccactgtaat cacagggact accagaatat ttcaagaaat     1020

ggtgcatctt cccgaaacct gaagaaattt atagaaagct tgtctagaaa caaggtgttg     1080

gactatcccg ccatcgttat atatgccatg attggaaatg atgtctgcag tgggaagagt     1140

gacccagtcc cagccatgac cactcctgag aaactctact ccaacgtcat gcagactctg     1200

aagcatctaa attcccacct gcccaatggc agccatgtta ttttgtatgg cttaccagat     1260

ggaacctttc tctgggataa tttgcacaac agatatcatc ctctcggcca gctaaataaa     1320

gacatgacct atgcgcagtt gtactccttc ctgaactgcc tccaggtcag cccctgccac     1380

ggctggatgt cttccaacaa gacgttgcgg actctcactt cagagagagc agagcaactc     1440

tccaacacac tgaaaaaaat tgcagccagt gagaaattta caaacttcaa tcttttctac     1500

atggattttg ccttccatga aatcatacag gagtggcaga agagaggcgg acagccctgg     1560

cagctcatcg agcccgtgga tggattccac cccaacgagg tggctttgct gttgttggcg     1620

gatcatttct ggaaaaaggt gcagctccag tggccccaaa tcctgggaaa ggagaatccg     1680

ttcaaccccc agattaaaca ggtgtttgga gaccaaggcg ggcactga                  1728


<210>  200
<211>  2001
<212>  DNA
<213>  Homo sapiens;

<400>  200
atgggtgagt caagtgaaga catagaccaa atgttcagca ctttgctggg agagatggat       60

cttctgactc agagtttagg agttgacact ctccctcctc ctgaccctaa tccacccaga      120

gctgaattta actacagtgt ggggtttaaa gatttaaatg agtccttaaa tgcactggaa      180

gaccaagatt tagatgctct catggcagat ctggtagcag acataagtga ggctgagcag      240

aggacaatcc aggcacagaa agagtccttg cagaatcaac atcattcagc atctctacaa      300

gcatcaattt tcagtggtgc agcctctctt ggttatggaa caaatgttgc tgccactggt      360

atcagccaat atgaggatga cttaccacct ccaccagccg atcctgtgtt agaccttcca      420

ctgccaccac cacctcctga acctctctct caggaagagg aagaagccca agccaaggct      480

gataaaatta agctggcgct ggaaaaactg aaggaggcca aggttaagaa gctcgtcgtc      540

aaggtgcaca tgaatgataa cagcacaaag tcactgatgg tggatgagcg gcagctggcc      600

cgagatgttc tggacaacct tttcgagaaa actcattgtg actgcaatgt agactggtgt      660

ctttatgaaa tctacccgga actacaaatt gagaggtttt ttgaagacca tgaaaatgtt      720

gttgaagtct tatcagactg gacaagagac acagaaaata aaatactatt tttggagaaa      780

gaggagaaat atgctgtatt taaaaacccc cagaatttct acttggataa cagaggaaaa      840

aaagaaagca aggaaactaa tgagaaaatg aatgctaaga acaaggaatc cttacttgag      900

gaaagtttct gtggaacatc tatcattgta ccagaactgg aaggagctct ttatttgaaa      960

gaagatggaa agaaatcctg gaaaaggcgc tattttcttt tacgggcttc tggaatttat     1020

tatgtaccca aaggaaagac taagacatct cgagatctgg cgtgttttat acagtttgaa     1080

aatgtcaaca tttactatgg gactcagcat aaaatgaaat ataaagcgcc cactgactat     1140

tgctttgttt taaagcaccc ccaaattcag aaggagtccc agtatatcaa gtatctctgc     1200

tgtgatgaca caagaaccct taaccagtgg gtcatgggaa tacggatagc caagtatggg     1260

aagactctct atgataacta ccagcgggct gtggcaaagg ctggacttgc ctctcggtgg     1320

acaaacttgg ggacagtcaa tgcagctgca ccagctcagc catctacagg acctaaaaca     1380

ggcaccaccc agcccaatgg acagattccc caggctacac attctgtcag tgctgttctc     1440

caagaggccc agagacatgc tgaaacatcg aaggataaga agccagccct cgggaaccac     1500

cacgacccgg cagtgccccg ggccccgcac gcccccaagt ccagcctgcc cccgccccct     1560

ccggtgcgga ggtcctccga caccagcggc agtcccgcca cgcccctcaa ggccaagggc     1620

acaggcggcg ggggcttgcc cgccccaccc gacgacttcc tgccgccgcc gccaccgccg     1680

ccgcccctcg atgaccctga gctcccgccg ccgcccccgg acttcatgga gccgccccca     1740

gacttcgtgc ccccgccccc gccgtcgtac gcagggatcg cgggctcaga gctgcccccg     1800

ccgccgccgc cgccgcccgc gcccgcgccc gcccccgtcc ccgactccgc caggccgccc     1860

cccgcggtgg ccaagaggcc tcctgtgccc cccaagaggc aagagaaccc agggcacccc     1920

ggcggagcag gaggcgggga gcaagatttc atgtcagacc tcatgaaagc tttgcaaaag     1980

aagagaggca acgtgtccta g                                               2001


<210>  201
<211>  2292
<212>  DNA
<213>  Homo sapiens;

<400>  201
atggcggcca ccgggaccgc ggccgccgca gccacgggca ggctcctgct tctgctgctg       60

gtggggctca cggcgcctgc cttggcgctg gccggctaca tcgaggctct tgcagccaat      120

gccggaacag gatttgctgt tgctgagcct caaatcgcaa tgttttgtgg gaagttaaat      180

atgcatgtga acattcagac tgggaaatgg gaacctgatc caacaggcac caagagctgc      240

tttgaaacaa aagaagaagt tcttcagtac tgtcaggaga tgtatccaga gctacagatc      300

acaaatgtga tggaggcaaa ccagcgggtt agtattgaca actggtgccg gagggacaaa      360

aagcaatgca agagtcgctt tgttacacct ttcaagtgtc tcgtgggtga atttgtaagt      420

gatgtcctgc tagttccaga aaagtgccag tttttccaca aagagcggat ggaggtgtgt      480

gagaatcacc agcactggca cacggtagtc aaagaggcat gtctgactca gggaatgacc      540

ttatatagct acggcatgct gctcccatgt ggggtagacc agttccatgg cactgaatat      600

gtgtgctgcc ctcagacaaa gattattgga tctgtgtcaa aagaagagga agaggaagat      660

gaagaggaag aggaagagga agatgaagag gaagactatg atgtttataa aagtgaattt      720

cctactgaag cagatctgga agacttcaca gaagcagctg tggatgagga tgatgaggat      780

gaggaagaag gggaggaagt ggtggaggac cgagattact actatgacac cttcaaagga      840

gatgactaca atgaggagaa tcctactgaa cccggcagcg acggcaccat gtcagacaag      900

gaaattactc atgatgtcaa agctgtctgc tcccaggagg cgatgacggg gccctgccgg      960

gccgtgatgc ctcgttggta cttcgacctc tccaagggaa agtgcgtgcg ctttatatat     1020

ggtggctgcg gcggcaacag gaacaatttt gagtctgagg attattgtat ggctgtgtgt     1080

aaagcgatga ttcctccaac tcctctgcca accaatgatg ttgatgtgta tttcgagacc     1140

tctgcagatg ataatgagca tgctcgcttc cagaaggcta aggagcagct ggagattcgg     1200

caccgcaacc gaatggacag ggtaaagaag gaatgggaag aggcagagct tcaagctaag     1260

aacctcccca aagcagagag gcagactctg attcagcact tccaagccat ggttaaagct     1320

ttagagaagg aagcagccag tgagaagcag cagctggtgg agacccacct ggcccgagtg     1380

gaagctatgc tgaatgaccg ccgtcggatg gctctggaga actacctggc tgccttgcag     1440

tctgacccgc cacggcctca tcgcattctc caggccttac ggcgttatgt ccgtgctgag     1500

aacaaagatc gcttacatac catccgtcat taccagcatg tgttggctgt tgacccagaa     1560

aaggcggccc agatgaaatc ccaggtgatg acacatctcc acgtgattga agaaaggagg     1620

aaccaaagcc tctctctgct ctacaaagta ccttatgtag cccaagaaat tcaagaggaa     1680

attgatgagc tccttcagga gcagcgtgca gatatggacc agttcactgc ctcaatctca     1740

gagacccctg tggacgtccg ggtgagctct gaggagagtg aggagatccc accgttccac     1800

cccttccacc ccttcccagc cctacctgag aacgaagaca ctcagccgga gttgtaccac     1860

ccaatgaaaa aaggatctgg agtgggagag caggatgggg gactgatcgg tgccgaagag     1920

aaagtgatta acagtaagaa taaagtggat gaaaacatgg tcattgacga gactctggat     1980

gttaaggaaa tgattttcaa tgccgagaga gttggaggcc tcgaggaaga gcgggaatcc     2040

gtgggcccac tgcgggagga cttcagtctg agtagcagtg ctctcattgg cctgctggtc     2100

atcgcagtgg ccattgccac ggtcatcgtc atcagcctgg tgatgctgag gaagaggcag     2160

tatggcacca tcagccacgg gatcgtggag gttgatccaa tgctcacccc agaagagcgt     2220

cacctgaaca agatgcagaa ccatggctat gagaacccca cctacaaata cctggagcag     2280

atgcagattt ag                                                         2292


<210>  202
<211>  3618
<212>  DNA
<213>  Homo sapiens;

<400>  202
atgaccaaga aggaggagcc cccaccgagc cgagtcccac gggccgtgcg cgtggccagt       60

ctgctgagcg agggagagga actgtctggg gacgaccaag gggatgagga agaggatgac      120

cacgcctatg agggcgtccc caatggcgga tggcatacca gcagcctgag cttgtccttg      180

cccagcacaa tagctgcgcc acaccccatg gacgggccgc ctgggggctc cacccccgtc      240

acaccagtca tcaaggctgg ctggctggac aagaacccac cgcagggatc ttacatctat      300

cagaaacgat gggtgagact ggatactgat cacctgcgat actttgacag taacaaggac      360

gcttactcta agcgctttat ctctgtggcc tgcatctccc acgtggctgc catcggggac      420

cagaagtttg aagtgatcac aaacaaccga acctttgcct tccgggcaga gagtgatgtg      480

gagcggaagg agtggatgca ggccctgcag caggccatgg ctgagcagcg tgcccgggcc      540

cggctctcta gcgcttatct gctgggagtt ccaggctcag agcagcctga ccgcgctggc      600

agcctggagc ttcgtggctt caagaataag ctgtacgtgg ccgtggtcgg ggacaaagtg      660

cagctctaca agaatctaga ggagtaccac ctgggcattg gcatcacctt catcgacatg      720

agcgtgggca acgtgaagga agtggaccgg cgcagcttcg acctcaccac gccctaccgc      780

atcttcagct tctctgctga ctcagagcta gagaaggagc agtggttgga ggccatgcag      840

ggagccatcg ctgaggccct gtctacctcg gaggtggccg agcgcatctg ggctgcagcc      900

cccaacaggt tctgtgctga ctgcggggct cctcagcctg actgggcctc catcaacctc      960

tgtgttgtta tctgcaagcg ctgtgcaggg gagcaccgtg gcctgggcgc tggcgtctcc     1020

aaggtgcgga gcctgaagat ggacaggaag gtgtggacag aaacacttat cgagctcttc     1080

ttacagctgg ggaatggcgc tgggaaccgc ttctgggcag ccaacgtgcc ccccagtgag     1140

gccctgcagc ccagcagcag ccccagcacc cggcggtgcc acctggaggc caagtaccgt     1200

gagggcaagt accgccgcta ccacccgctc tttggcaacc aggaggagct ggacaaggcc     1260

ctgtgtgctg cagtcaccac cacagacctg gctgagaccc aggcgctcct gggctgtggg     1320

gctgggatca actgcttctc gggggaccct gaggccccca cgcccctggc tcttgcagag     1380

caggcggggc agacgctgca gatggaattc cttcggaaca accggaccac agaggtgcct     1440

cggctggact cgatgaagcc cctggaaaag cactactcag ttgtcctgcc gaccgtgagc     1500

cacagtggct tcctctacaa gactgcctct gccggcaagc tgctacagga ccgccgggcc     1560

cgggaagagt tcagccggcg ctggtgtgtc cttggtgacg gggtcctgag ctactttgag     1620

aatgagcggg cagtgacccc caatggagag attcgggcca gcgagattgt gtgcctggca     1680

gtgccccctc ctgacaccca tggctttgag cacacctttg aggtgtacac ggagggagaa     1740

cggctgtacc tgtttgggct ggagagtgcg gagcaggctc atgagtgggt caagtgtatt     1800

gctaaggcat tcgtgcctcc cctagccgag gatctgctgg cccgggattt tgagcggctg     1860

ggacgcctac cctacaaagc tggcctgagc ctacagcggg cccaggaggg ctggttctct     1920

ctcagtggct cggagctccg tgctgtcttc ccggaggggc cctgcgaaga gccgctgcaa     1980

ctacggaaac tgcaggagct ttccatccag ggggacagtg agaaccaggt gctggtgctg     2040

gtggagcgaa ggaggacact gtacatacag ggcgagcggc ggctggactt catgggttgg     2100

ctgggggcca tccagaaagc agccgccagc atgggggaca cgctgtcgga gcagcagctt     2160

ggggactcgg atatcccggt gatcgtgtac cgctgtgtgg actacatcac gcagtgcggc     2220

ctgacctccg agggcatcta ccgcaagtgt gggcagacat cgaagacaca gcggctgctg     2280

gagagcctgc ggcaggatgc gcgctctgtg cacctcaagg agggcgagca gcacgtggat     2340

gatgtttcct cggcgctcaa gcgcttcctg cgcgacctgc ctgatgggct cttcactcgc     2400

gcccagcgcc taacctggct ggaggcctca gagattgagg acgaggagga gaaggtctcc     2460

aggtaccgag agctgctggt gcggctgccc cctgtcaacc gggccacagt gaaggccctt     2520

atcagccacc tgtactgtgt tcagtgcttc tcagacacga accagatgaa cgtgcacaac     2580

ctggcaattg tgtttgggcc cacgctcttc cagacagatg ggcaggacta caaggctggc     2640

cgtgtggtgg aagacctcat taaccactat gtggtggtgt ttagtgtgga tgaggaagag     2700

ctcaggaagc agcgggagga gatcactgcc attgtgaaga tgcgcgtggc tggcactgcc     2760

agtgggaccc agcatgccgg tgacttcatc tgcacagtgt atctggaaga gaagaaggca     2820

gagactgagc agcatatcaa ggtcccagca tccatgactg ctgaggagct caccctggag     2880

atcctggatc gccggaacgt gggcatcagg gagaaggact attggacctg ctttgaggtc     2940

aacgagaggg aggaggcaga gcgccccctg cactttgcgg agaaggtgct gcccatcctg     3000

cacgggctgg gcacggacag ccacctggtg gtgaagaagc accaggccat ggaggccatg     3060

ctgctgtacc tggccagccg tgtcggtgac accaagcatg gcatgatgaa gttccgtgag     3120

gaccgcagcc tcctgggcct gggcctgccc tcaggtggct tccacgatcg ctacttcatc     3180

ctcaacagca gctgcttgcg gctctacaag gaggtccgga gccagaggcc gtggagcggg     3240

gcccctgaga ccagtcaccg gcctgagaag gagtggccta ttaagagtct caaagtctac     3300

ctgggagtga agaagaaact caggccaccc acctgctggg gcttcacagt ggtgcatgag     3360

acagagaaac atgagaagca gcagtggtac ctctgctgtg acacacagat ggagctccgg     3420

gagtggttcg ctacctttct gtttgtgcag catgacggcc tggtgtggcc ctcagagccc     3480

tcacgcgtgt cccgggcagt gcctgaggtc cggctgggta gtgtgtcact gatccccctt     3540

cgaggtagtg aaaatgaaat gcgccggagt gtggctgcct tcaccgcgga ccctctgtct     3600

cttctgcgca acgtctga                                                   3618


<210>  203
<211>  1428
<212>  DNA
<213>  Homo sapiens;

<400>  203
atgcagaaat ctacaaattc tgatacttcc gtggaaacac tgaattctac ccgccaaggc       60

acaggagctg tgcaaatgag aatcaaaaat gccaacagcc accatgacag gctcagccaa      120

agtaaatcca tgatcctcac cgatgtcggg aaggtcactg aacctatatc cagacacaga      180

aggaatcatt cacagcatat cttgaaagat gtcattcctc cattggaaca actgatggtt      240

gaaaaagaag gttatctgca aaaagctaaa attgcagatg gaggaaagaa actaaggaaa      300

aactggtcta cttcctggat tgttctttct agtcgaagaa ttgaatttta caaagaatcc      360

aagcaacagg ctctgtccaa tatgaaaact gggcacaaac cagaaagtgt ggatttgtgt      420

ggagcacaca ttgaatgggc caaggaaaaa tcgagcagaa agaatgtctt tcagatcaca      480

acagtatcag gaaatgagtt ccttctacag tcagatattg acttcatcat attggattgg      540

ttccacgcta tcaaaaatgc aattgacaga ttgccaaagg attcaagttg tccatcaaga      600

aacctggaat tattcaaaat ccaaagatcc tctagcactg aattgctaag tcactacgac      660

agtgatataa aagaacagaa accagagcac agaaaatctt taatgttcag actgcatcac      720

agtgcttccg atacaagcga caaaaatcga gttaaaagca gattaaagaa gtttattacc      780

cgaagacctt ccctgaaaac tctgcaagaa aaaggactta ttaaagatca aatttttggc      840

tctcatctgc acaaagtgtg tgaacgtgaa aattccacag ttccgtggtt tgtaaagcaa      900

tgcattgaag ctgttgagaa aagaggtcta gatgttgatg gaatatatcg agttagtggc      960

aatctggcaa caatacagaa gttaagattt attgtcaacc aagaagagaa gctgaatttg     1020

gacgacagcc agtgggagga catccacgtt gtcaccggag cactgaagat gtttttccgg     1080

gagctgcctg agccgctctt cccttacagt ttctttgagc agtttgtgga agcgatcaaa     1140

aagcaagaca acaacacaag aattgaagct gtaaaatctc ttgtacaaaa actccctccg     1200

ccaaatcgtg acaccatgaa agtcctcttt ggacatctaa ctaagatagt ggccaaagcc     1260

tccaagaacc tcatgtccac gcaaagcttg gggattgtat ttggacctac ccttctgcga     1320

gctgaaaatg aaacaggaaa catggcgatc cacatggtct accagaacca gatagctgag     1380

ctcatgctga gtgagtacag taagatcttc ggctcagagg aagactga                  1428


<210>  204
<211>  1917
<212>  DNA
<213>  Homo sapiens;

<400>  204
atgtccctcg gtcagtcggc ctgtctgttc ctctctatag ctcggtcaag gagtgtgatg       60

actggcgagc agatggctgc cttccatcca tcgtccaccc ccaacccgct ggagaggccc      120

atcaagatgg gctggctgaa gaagcagagg tccatcgtga agaactggca gcagaggtac      180

tttgtgctga gggcgcagca gctctactac tacaaggatg aagaggacac gaagccccag      240

ggctgcatgt atctaccagg atgtacaatc aaggagatcg ccacaaaccc agaagaagct      300

gggaagtttg tctttgaaat cattccagcc tcatgggacc agaatcgcat gggacaggac      360

tcctatgtcc tcatggccag ctctcaggcg gagatggagg agtgggttaa attcctcagg      420

agagttgctg gcacaccctg tggagtgttt ggccagcgct tggatgagac tgtggcctat      480

gaacagaaat tcggccccca tctggtgccc atcctggtgg agaaatgtgc agagttcatc      540

ctggagcacg gccggaatga agagggcatc ttccgtctgc ctgggcagga caacctggtg      600

aagcagctga gagacgcttt tgatgctggg gagcggccct cctttgacag agacacagat      660

gtgcacactg tggcttccct gttaaagctc tacctccgag acctcccaga gcccgtggtt      720

ccctggagcc agtacgaagg gttcctgctc tgtgggcagc tcacgaatgc ggatgaggca      780

aaggctcagc aggagttgat gaagcagctc tccatccttc ctcgtgacaa ctatagtctc      840

ctgagctaca tctgcaggtt cctacatgaa atacagctga actgtgctgt taacaagatg      900

agtgtggaca acctggctac tgtgattggt gtgaatctca tcaggtcgaa ggtcgaagac      960

cctgccgtga tcatgagagg gactcctcag atccaaagag tgatgactat gatgatcaga     1020

gaccatgaag tcctcttccc caagtccaag gatatacccc tgtcaccccc tgcccagaaa     1080

aatgacccca agaaagctcc agtggcccga agctctgtag gctgggatgc cactgaagac     1140

ctccgaattt ctaggacaga cagcttcagt agcatgacaa gcgactctga tacaaccagc     1200

cccaccggac agcagccgag cgatgcgttt ccggaggaca gcagcaaagt acccagggaa     1260

aagccaggag actggaaaat gcaatctcgt aaaaggactc aaacactccc taaccggaaa     1320

tgtttcttga catcagcttt tcagggtgcc aacagcagca aaatggagat ctttaaaaat     1380

gaattctggt cgccttcctc agaggctaag gcaggggaag ggcacaggag aacgatgtct     1440

caagacttgc gccaactttc tgactcccaa cggacttcca cctacgataa cgtcccttcc     1500

ctgccagggt cccctgggga ggaagccagt gcactctctt cccaagcctg tgactccaag     1560

ggagatactc ttgccagtcc aaactctgaa actgggcctg gaaaaaagaa ctctggagaa     1620

gaggaaattg attctttgca gaggatggtc caagagctac gaaaggaaat agaaacacag     1680

aagcaaatgt atgaggaaca gattaaaaac cttgagaagg aaaattatga cgtttgggct     1740

aaagtggtga ggctcaatga agaactggag aaggaaaaga agaagtctgc agccctagag     1800

atcagcctcc gcaacatgga gcgctcccgg gaggatgttg agaagaggaa caaggccttg     1860

gaagaagaag tcaaggaatt tgtcaaatcc atgaaggaac ccaagaccga ggcttaa        1917


<210>  205
<211>  2445
<212>  DNA
<213>  Homo sapiens;

<400>  205
atggggctcc cagcgctcga gttcagcgac tgctgcctcg atagtccgca cttccgagag       60

acgctcaagt cgcacgaagc agagctggac aagaccaaca aattcatcaa ggagctcatc      120

aaggacggga agtcactcat aagcgcgctc aagaatttgt cttcagcgaa gcggaagttt      180

gcagattcct taaatgaatt taaatttcag tgcataggag atgcagaaac agatgatgag      240

atgtgtatag caagatcttt gcaggagttt gccactgtcc tcaggaatct tgaagatgaa      300

cggatacgga tgattgagaa tgccagcgag gtgctcatca ctcccttgga gaagtttcga      360

aaggaacaga tcggggctgc caaggaagcc aaaaagaagt atgacaaaga gacagaaaag      420

tattgtggca tcttagaaaa acacttgaat ttgtcttcca aaaagaaaga atctcagctt      480

caggaggcag acagccaagt ggacctggtc cggcagcatt tctatgaagt atccctggaa      540

tatgtcttca aggtgcagga agtccaagag agaaagatgt ttgagtttgt ggagcctctg      600

ctggccttcc tgcaaggact cttcactttc tatcaccatg gttacgaact ggccaaggat      660

ttcggggact tcaagacaca gttaaccatt agcatacaga acacaagaaa tcgctttgaa      720

ggcactagat cagaagtgga atcactgatg aaaaagatga aggagaatcc ccttgagcac      780

aagaccatca gtccctacac catggaggga tacctctacg tgcaggagaa acgtcacttt      840

ggaacttctt gggtgaagca ctactgtaca tatcaacggg attccaaaca aatcaccatg      900

gtaccatttg accaaaagtc aggaggaaaa gggggagaag atgaatcagt tatcctcaaa      960

tcctgcacac ggcggaaaac agactccatt gagaagaggt tttgctttga tgtggaagca     1020

gtagacaggc caggggttat caccatgcaa gctttgtcgg aagaggaccg gaggctctgg     1080

atggaagcca tggatggccg ggaacctgtc tacaactcga acaaagacag ccagagtgaa     1140

gggactgcgc agttggacag cattggcttc agcataatca ggaaatgcat ccatgctgtg     1200

gaaaccagag ggatcaacga gcaagggctg tatcgaattg tgggtgtcaa ctccagagtg     1260

cagaagttgc tgagtgtcct gatggacccc aagactgctt ctgagacaga aacagatatc     1320

tgtgctgaat gggagataaa gaccatcact agtgctctga agacctacct aagaatgctt     1380

ccaggaccac tcatgatgta ccagtttcaa agaagtttca tcaaagcagc aaaactggag     1440

aaccaggagt ctcgggtctc tgaaatccac agccttgttc atcggctccc agagaaaaat     1500

cggcagatgt tacagctgct catgaaccac ttggcaaatg ttgctaacaa ccacaagcag     1560

aatttgatga cggtggcaaa ccttggtgtg gtgtttggac ccactctgct gaggcctcag     1620

gaagaaacag tagcagccat catggacatc aaatttcaga acattgtcat tgagatccta     1680

atagaaaacc acgaaaagat atttaacacc gtgcccgata tgcctctcac caatgcccag     1740

ctgcacctgt ctcggaagaa gagcagtgac tccaagcccc cgtcctgcag cgagaggccc     1800

ctgacgctct tccacaccgt tcagtcaaca gagaaacagg aacaaaggaa cagcatcatc     1860

aactccagtt tggaatctgt ctcatcaaat ccaaacagca tccttaattc cagcagcagc     1920

ttacagccca acatgaactc cagtgaccca gacctggctg tggtcaaacc cacccggccc     1980

aactcactcc ccccgaatcc aagcccaact tcacccctct cgccatcttg gcccatgttc     2040

tcggcgccat ccagccctat gcccacctca tccacgtcca gcgactcatc ccccgtcagg     2100

tctgttgcag ggtttgtttg gttttctgtt gctgccgttg ttctctcatt ggctcggtcc     2160

tctcttcatg cagtgttcag cctcctcgtc aactttgttc cctgccatcc aaacctgcac     2220

ttgctttttg acaggccaga agaagcggta catgaagact ccagcacacc gttccggaag     2280

gcaaaagcct tgtatgcctg caaagctgaa catgactcag aactttcgtt cacagcaggc     2340

acggtcttcg ataacgttca cccatctcag gagcctggct ggttggaggg gactctgaac     2400

ggaaagactg gcctcatccc tgagaattac gtggagttcc tctaa                     2445


<210>  206
<211>  2877
<212>  DNA
<213>  Homo sapiens;

<400>  206
atgaaggaag ccaaggatgc ccgctatacc aatgggcacc tcttcaccac catttcagtt       60

tcaggcatga ccatgtgcta tgcctgtaac aagagcatca cagccaagga agccctcatc      120

tgcccaacct gcaatgtgac tatccacaac cgctgtaaag acaccctcgc caactgtacc      180

aaggtcaagc agaagcaaca gaaagcggcc ctgctgaaga acaacaccgc cttgcagtcc      240

gtttctcttc gaagtaagac aaccatccgg gagcggccaa gctcggccat ctacccctcc      300

gacagcttcc ggcagtccct cctgggctcc cgccgtggcc gctcctcctt gtctttagcc      360

aagagtgttt ctaccaccaa cattgctgga catttcaatg atgagtctcc cctggggctg      420

cgccggatcc tctcacagtc cacagactcc ctcaacatgc ggaaccgaac cctatccgtg      480

gaatccctca ttgacgaaga ggtaatctac agtgagctga tgagtgactt tgagatggat      540

gagaaggact ttgcagctga ctcttggagt cttgctgtgg acagcagctt cctgcagcag      600

cataaaaagg aggtgatgaa gcagcaagat gtcatctatg agctaatcca gacagagctg      660

caccatgtga ggacactgaa gatcatgacc cgcctcttcc gcacggggat gctggaagag      720

ctacacttgg agccaggagt ggtccagggc ctgttcccct gcgtggacga gctcagtgac      780

atccatacac gcttcctcag ccagctatta gaacgccgac gccaggccct gtgccctggc      840

agcacccgga actttgtcat ccatcgcttg ggtgatctgc tcatcagcca gttctcaggt      900

cctagtgcgg agcagatgtg taagacctac tcggagttct gcagccgcca cagcaaggcc      960

ttaaagctct ataaggagct gtacgcccga gacaaacgct tccagcaatt catccggaaa     1020

gtgacccgcc ccgccgtgct caagcggcac ggggtacagg agtgcatcct gctggtgact     1080

cagcgcatca ccaagtaccc gttactcatc agccgcatcc tgcagcattc ccacgggatc     1140

gaggaggagc gccaggacct gaccacagca ctggggctag tgaaggagct gctgtccaat     1200

gtggacgagg gtatttatca gctggagaaa ggggcccgtc tgcaggagat ctacaaccgc     1260

atggaccctc gggcccaaac cccagtgcct ggcaagggcc cctttggccg agaggaactt     1320

ctgaggcgca aactcatcca cgatggctgc ctgctctgga agacagcgac ggggcgcttc     1380

aaagatgtgc tagtgctgct gatgacagat gtactggtgt ttctccagga aaaggaccag     1440

aagtacatct ttcctaccct ggacaagcct tcagtggtat cgctgcagaa tctaatcgta     1500

cgagacattg ccaaccagga gaaagggatg tttctgatca gcgcagcccc acctgagatg     1560

tacgaggtgc acacagcatc ccgggatgac cggagcacct ggatccgggt cattcagcag     1620

agcgtgcgca catgcccatc cagggaggac ttccccctga ttgagacaga ggatgaggct     1680

tacctgcggc gaattaagat ggagttgcag cagaaggacc gggcactggt ggagctgctg     1740

cgagagaagg tcgggctgtt tgctgagatg acccatttcc aggccgaaga ggatggtggc     1800

agtgggatgg ccctgcccac cctgcccagg ggccttttcc gctctgagtc ccttgagtcc     1860

cctcgtggcg agcggctgct gcaggatgcc atccgtgagg tggagggtct gaaagacctg     1920

ctggtggggc caggagtgga actgctcttg acaccccgag agccagccct gcccttggaa     1980

ccagacagcg gtggtaacac gagtcctggg gtcactgcca atggtgaggc cagaaccttc     2040

aatggctcca ttgaactctg cagagctgac tcagactcta gccagaggga tcgaaatgga     2100

aatcagctga gatcaccgca agaggaggcg ttacagcgat tggtcaatct ctatggactt     2160

ctacatggcc tacaggcagc tgtggcccag caggacactc tgatggaagc ccggttccct     2220

gagggccctg agcggcggga gaagctgtgc cgagccaact ctcgggatgg ggaggctggc     2280

agggctgggg ctgcccctgt ggcccctgaa aagcaggcca cggaactggc attactgcag     2340

cggcaacatg cgctgctgca ggaggagcta cggcgctgcc ggcggctagg tgaagaacgg     2400

gcaaccgaag ctggcagcct ggaggcccgg ctccgggaga gtgagcaggc ccgggcactg     2460

ctggagcgtg aggccgaaga ggctcgaagg cagctggccg ccctgggcca gaccgagcca     2520

ctcccagctg aggccccctg ggcccgcaga cctgtggatc ctcggcggcg cagcctcccc     2580

gcaggcgatg ccctgtactt gagtttcaac cccccacagc ccagccgagg cactgaccgc     2640

ctggatctac ctgtcactac tcgctctgtc catcgaaact ttgaggaccg agagaggcag     2700

gaactgggga gccccgaaga gcggctgcaa gacagcagtg accctgacac tggcagcgag     2760

gaggaaggta gcagccgtct gtctccgccc cacagtccac gagactttac cagaatgcag     2820

gacatcccgg aggagacgga gagccgcgac ggggaggctg tagcctccga gagctaa        2877


<210>  207
<211>  1257
<212>  DNA
<213>  Homo sapiens;

<400>  207
atgggcgaca aagggacccg agtgttcaag aaggccagtc caaatggaaa gctcaccgtc       60

tacctgggaa agcgggactt tgtggaccac atcgacctcg tggaccctgt ggatggtgtg      120

gtcctggtgg atcctgagta tctcaaagag cggagagtct atgtgacgct gacctgcgcc      180

ttccgctatg gccgggagga cctggatgtc ctgggcctga cctttcgcaa ggacctgttt      240

gtggccaacg tacagtcgtt cccaccggcc cccgaggaca agaagcccct gacgcggctg      300

caggaacgcc tcatcaagaa gctgggcgag cacgcttacc ctttcacctt tgagatccct      360

ccaaaccttc catgttctgt gacactgcag ccggggcccg aagacacggg gaaggcttgc      420

ggtgtggact atgaagtcaa agccttctgc gcggagaatt tggaggagaa gatccacaag      480

cggaattctg tgcgtctggt catccggaag gttcagtatg ccccagagag gcctggcccc      540

cagcccacag ccgagaccac caggcagttc ctcatgtcgg acaagccctt gcacctagaa      600

gcctctctgg ataaggagat ctattaccat ggagaaccca tcagcgtcaa cgtccacgtc      660

accaacaaca ccaacaagac ggtgaagaag atcaagatct cagtgcgcca gtatgcagac      720

atctgccttt tcaacacagc tcagtacaag tgccctgttg ccatggaaga ggctgatgac      780

actgtggcac ccagctcgac gttctgcaag gtctacacac tgaccccctt cctagccaat      840

aaccgagaga agcggggcct cgccttggac gggaagctca agcacgaaga cacgaacttg      900

gcctctagca ccctgttgag ggaaggtgcc aaccgtgaga tcctggggat cattgtttcc      960

tacaaagtga aagtgaagct ggtggtgtct cggggcggcc tgttgggaga tcttgcatcc     1020

agcgacgtgg ccgtggaact gcccttcacc ctaatgcacc ccaagcccaa agaggaaccc     1080

ccgcatcggg aagttccaga gaacgagacg ccagtagata ccaatctcat agaacttgac     1140

acaaatgatg acgacattgt atttgaggac tttgctcgcc agagactgaa aggcatgaag     1200

gatgacaagg aggaagagga ggatggtacc ggctctccac agctcaacaa cagatag        1257


<210>  208
<211>  1230
<212>  DNA
<213>  Homo sapiens;

<400>  208
atgggggaga aacccgggac cagggtcttc aagaagtcga gccctaactg caagctcacc       60

gtgtacttgg gcaagcggga cttcgtagat cacctggaca aagtggaccc tgtagatggc      120

gtggtgcttg tggaccctga ctacctgaag gaccgcaaag tgtttgtgac cctcacctgc      180

gccttccgct atggccgtga agacctggat gtgctgggct tgtccttccg caaagacctg      240

ttcatcgcca cctaccaggc cttccccccg gtgcccaacc caccccggcc ccccacccgc      300

ctgcaggacc ggctgctgag gaagctgggc cagcatgccc accccttctt cttcaccata      360

ccccagaatc ttccatgctc cgtcacactg cagccaggcc cagaggatac aggaaaggcc      420

tgcggcgtag actttgagat tcgagccttc tgtgctaaat cactagaaga gaaaagccac      480

aaaaggaact ctgtgcggct ggtgatccga aaggtgcagt tcgccccgga gaaacccggc      540

ccccagcctt cagccgaaac cacacgccac ttcctcatgt ctgaccggtc cctgcacctc      600

gaggcttccc tggacaagga gctgtactac catggggagc ccctcaatgt aaatgtccac      660

gtcaccaaca actccaccaa gaccgtcaag aagatcaaag tctctgtgag acagtacgcc      720

gacatctgcc tcttcagcac cgcccagtac aagtgtcctg tggctcaact cgaacaagat      780

gaccaggtat ctcccagctc cacattctgt aaggtgtaca ccataacccc actgctcagc      840

gacaaccggg agaagcgggg tctcgccctg gatgggaaac tcaagcacga ggacaccaac      900

ctggcttcca gcaccatcgt gaaggagggt gccaacaagg aggtgctggg aatcctggtg      960

tcctacaggg tcaaggtgaa gctggtggtg tctcgaggcg gggatgtctc tgtggagctg     1020

ccttttgttc ttatgcaccc caagccccac gaccacatcc ccctccccag accccagtca     1080

gccgctccgg agacagatgt ccctgtggac accaacctca ttgaatttga taccaactat     1140

gccacagatg atgacattgt gtttgaggac tttgcccggc ttcggctgaa ggggatgaag     1200

gatgacgact atgatgatca actctgctag                                      1230


<210>  209
<211>  3390
<212>  DNA
<213>  Homo sapiens;

<400>  209
atgagatctt cagcctccag gctctccagt ttttcgtcga gagattcact atggaatcgg       60

atgccggacc agatctctgt ctcggagttc atcgccgaga ccaccgagga ctacaactcg      120

cccaccacgt ccagcttcac cacgcggctg cacaactgca ggaacaccgt cacgctgctg      180

gaggaggctc tagaccaaga tagaacagcc cttcagaaag tgaagaagtc tgtaaaagca      240

atatataatt ctggtcaaga tcatgtacaa aatgaagaaa actatgcaca agttcttgat      300

aagtttggga gtaatttttt aagtcgagac aaccccgacc ttggcaccgc gtttgtcaag      360

ttttctactc ttacaaagga actgtccaca ctgctgaaaa atctgctcca gggtttgagc      420

cacaatgtga tcttcacctt ggattctttg ttaaaaggag acctaaaggg agtcaaagga      480

gatctcaaga agccatttga caaagcctgg aaagattatg agacaaagtt tacaaaaatt      540

gagaaagaga aaagagagca cgcaaaacaa catgggatga tccgcacaga gataacagga      600

gctgagattg cggaagaaat ggagaaggaa aggcgcctct ttcagctcca aatgtgtgaa      660

tatctcatta aagttaatga aatcaagacc aaaaagggtg tggatctgct gcagaatctt      720

ataaagtatt accatgcaca gtgcaatttc tttcaagatg gcttgaaaac agctgataag      780

ttgaaacagt acattgaaaa actggctgct gatttatata atataaaaca gacccaggat      840

gaagaaaaga aacagctaac tgcactccga gacttaataa aatcctctct tcaactggat      900

cagaaagaag attctcagag ccggcaagga ggatacagca tgcatcagct ccagggcaat      960

aaggaatatg gcagtgaaaa gaaggggtac ctgctaaaga aaagtgacgg gatccggaaa     1020

gtatggcaga ggaggaagtg ttcagtcaag aatgggattc tgaccatctc acatgccaca     1080

tctaacaggc aaccagccaa gttgaacctt ctcacctgcc aagtaaaacc taatgccgaa     1140

gacaaaaaat cttttgacct gatatcacat aatagaacat atcactttca ggcagaagat     1200

gagcaggatt atgtagcatg gatatcagta ttgacaaata gcaaagaaga ggccctaacc     1260

atggccttcc gtggagagca gagtgcggga gagaacagcc tggaagacct gacaaaagcc     1320

attattgagg atgtccagcg gctcccaggg aatgacattt gctgcgattg tggctcatca     1380

gaacccacct ggctttcaac caacttgggt attttgacct gtatagaatg ttctggcatc     1440

catagggaaa tgggggttca tatttctcgc attcagtctt tggaactaga caaattagga     1500

acttctgaac tcttgctggc caagaatgta ggaaacaata gttttaatga tattatggaa     1560

gcaaatttac ccagcccctc accaaaaccc accccttcaa gtgatatgac tgtacgaaaa     1620

gaatatatca ctgcaaagta tgtagatcat aggttttcaa ggaagacctg ttcaacttca     1680

tcagctaaac taaatgaatt gcttgaggcc atcaaatcca gggatttact tgcactaatt     1740

caagtctatg cagaaggggt agagctaatg gaaccactgc tggaacctgg gcaggagctt     1800

ggggagacag cccttcacct tgccgtccga actgcagatc agacatctct ccatttggtt     1860

gacttccttg tacaaaactg tgggaacctg gataagcaga cggccctggg aaacacagtt     1920

ctacactact gtagtatgta cagtaaacct gagtgtttga agcttttgct caggagcaag     1980

cccactgtgg atatagttaa ccaggctgga gaaactgccc tagacatagc aaagagacta     2040

aaagctaccc agtgtgaaga tctgctttcc caggctaaat ctggaaagtt caatccacac     2100

gtccacgtag aatatgagtg gaatcttcga caggaggaga tagatgagag cgatgatgat     2160

ctggatgaca aaccaagccc tatcaagaaa gagcgctcac ccagacctca gagcttctgc     2220

cactcctcca gcatctcccc ccaggacaag ctggcactgc caggattcag cactccaagg     2280

gacaaacagc ggctctccta tggagccttc accaaccaga tcttcgtttc cacaagcaca     2340

gactcgccca catcaccaac cacggaggct ccccctctgc ctcctaggaa cgccgggaaa     2400

ggtccaactg gcccaccttc aacactccct ctaagcaccc agacctctag tggcagctcc     2460

accctatcca agaagaggcc tcctccccca ccacccggac acaagagaac cctatccgac     2520

cctcccagcc cactacctca tgggccccca aacaaaggcg cagttccttg gggtaacgat     2580

gggggtccat cctcttcaag taagactaca aacaagtttg agggactatc ccagcagtcg     2640

agcaccagtt ctgcaaagac tgcccttggc ccaagagttc ttcctaaact acctcagaaa     2700

gtggcactaa ggaaaacaga tcatctctcc ctagacaaag ccaccatccc gcccgaaatc     2760

tttcagaaat catcacagtt ggcagagttg ccacaaaagc caccacctgg agacctgccc     2820

ccaaagccca cagaactggc ccccaagccc caaattggag atttgccgcc taagccagga     2880

gaactgcccc ccaaaccaca gctgggggac ctgccaccca aaccccaact ctcagactta     2940

cctcccaaac cacagatgaa ggacctgccc cccaaaccac agctgggaga cctgctagca     3000

aaatcccaga ctggagatgt ctcacccaag gctcagcaac cctctgaggt cacactgaag     3060

tcacacccat tggatctatc cccaaatgtg cagtccagag acgccatcca aaagcaagca     3120

tctgaagact ccaacgacct cacgcctact ctgccagaga cgcccgtacc actgcccaga     3180

aaaatcaata cggggaaaaa taaagtgagg cgagtgaaga ccatttatga ctgccaggca     3240

gacaacgatg acgagctcac attcatcgag ggagaagtga ttatcgtcac aggggaagag     3300

gaccaggagt ggtggattgg ccacatcgaa ggacagcctg aaaggaaggg ggtctttcca     3360

gtgtcctttg ttcatatcct gtctgactag                                      3390


<210>  210
<211>  4377
<212>  DNA
<213>  Homo sapiens;

<400>  210
atggtgaaca cccggaagag ctctctccgc cttctcgggt ccaagtctcc tggtcccggg       60

cctgggcctg gggccggagc agagcctggg gcgaccggag gcagcagcca tttcatctcc      120

tctcggaccc gctcctccaa gacccgcgcc gccagctgcc ccgccgccaa agccggggga      180

agcggtggcg ccggcgtcac tctggatgag gccaggaaag ttgaagttga tggtagttta      240

agtgatagcc acgtatctcc tccagccaaa cgcactttga aacaacctga ttctgtttgc      300

aaagacaaat caaaatcacg aagtactggt cagcgagagg aatggaactt atcaactgga      360

caggccaggt taacttctca gcctggtgct acattaccaa atggacatag tggcttatcc      420

cttcgaagcc atccccttcg aggggaaaag aagggagatg gggacctttc ttgtataaat      480

ggtgacatgg aagtcagaaa aagttgtcgt tccaggaaaa acagatttga aagtgtgaac      540

cagagtttgt tatttgatca actagtaaat agcactgctg aagctgtact acaggaaatg      600

gacaacatta acatccgacg gaatcgtcga tcaggagaag tagaacgact tcgaatgtgg      660

acagatacag aatttgaaaa catggatatg tattcaagag tgaaaaggcg aagaaagtca      720

ctaagaagaa atagttatgg gatacaaaat catcatgaag tttctactga gggtgaagaa      780

gaagaatctc aagaggagga tggagatata gaagttgaag aggcagaagg agaagaaaat      840

gatagaccat ataatttgag acagagaaaa acagtggatc gataccaagc acctccaata      900

gtaccagctc atcaaaaaaa gagggaaaac acgctgtttg atattcatag atctccagca      960

agaagaagcc atattaggag aaagaagcat gccattcata gtagtgacac aacttcttct     1020

gatgaggaac gctttgaaag aaggaaatca aagagcatgg caagagcaag aaatagatgt     1080

ttgcctatga acttcagagc agaggactta gctagcggta ttctccgaga acgagtgaaa     1140

gtgggtgcaa gcttggctga tgttgatcca atgaacattg ataaatcagt acggtttgat     1200

agcataggtg gattgagcca tcatattcat gcgctaaagg aaatggtagt attcccactt     1260

ttatatccag aaatttttga aaagtttaaa attcagcctc caaggggctg tttgttttat     1320

ggccctcctg gcacaggtaa aaccttggtt gccagagcat tagctaatga atgcagccaa     1380

ggagacaaaa aagtggcttt ttttatgcga aaaggagcag attgtttgag caagtgggtt     1440

ggtgaatctg aaaggcaact taggcttctt tttgatcagg catatttgat gagaccttct     1500

ataatatttt ttgatgaaat agatggatta gctccagttc gctctagcag acaagatcag     1560

atccacagct ctatagtatc aaccctcctt gctcttatgg atggattaga taataggggt     1620

gaaattgttg ttattggtgc tacaaacaga cttgactcta tagatcctgc actcaggaga     1680

cctggtcgtt ttgacagaga attcctcttc aacctgcctg atcaaaaggc aagaaaacac     1740

atcttacaga tccataccag ggactggaat ccaaaattgt cagatgcatt tttaggtgaa     1800

ttggctgaaa aatgtgttgg ctactgtgga gccgatatca aggccctgtg cactgaagcc     1860

gccctgattg cactgcggag gcgttatccc cagatctatg ctagcagtca taaactgcag     1920

ctggatgttt cctcaatagt gcttagtgcc caagattttt accatgcaat gcagaatatc     1980

gtgcctgctt cccaacgtgc tgtgatgtct tcagggcatg cactatcccc catcataaga     2040

ccactgctgg aaagaagctt caacaacatc ctagcagtct tgcaaaaagt gtttcctcat     2100

gctgaaatta gccagagtga caaaaaagaa gatatagaaa ctttaatttt agaggatagt     2160

gaagatgaaa atgctttatc aatttttgag accaattgtc actcaggatc accaaagaaa     2220

cagtcatcat ctgctgctat acataaaccc taccttcatt ttacaatgtc accatatcat     2280

cagccaacct cttacaggcc acgcttattg ctctctggag aacggggctc aggtcaaact     2340

tctcaccttg ctccagcact tttgcacact ctagaaagat tctctgtgca tagactagat     2400

ctcccagcac tttattcagt tagtgccaaa acacctgagg aatcatgtgc acagattttt     2460

cgtgaagctc gaagaacagt acctagtatt gtttacatgc ctcacattgg ggattggtgg     2520

gaagctgtca gtgaaactgt gagagcaact tttctgacat tgctacaaga tataccatca     2580

ttttcaccta tatttttatt gtctacctct gaaaccatgt acagtgaact gcctgaagag     2640

gttaaatgta tctttagaat acagtatgaa gaggtcttgt atattcaaag gcctattgaa     2700

gaagacagaa gaaaattttt tcaagaattg attctcaatc aggcatcaat ggctccacca     2760

cgaaggaaac atgctgctct ttgtgctatg gaagtgcttc ctcttgcact accttctcca     2820

cctcgtcaat tatcagaatc agaaaaaagt cgaatggagg accaggagga aaatacttta     2880

agagagttgc ggttgtttct cagggatgta accaagaggc tggccacaga taaacgcttt     2940

aacatcttca gcaaaccggt ggatattgaa gaggtttcag attatcttga agtaatcaag     3000

gaaccaatgg acttatcaac agtaataact aaaattgata aacataatta cctgactgca     3060

aaggatttcc tgaaagatat tgacctcatc tgtagcaatg ctttagagta taatccagat     3120

aaggacccag gagataaaat aattaggcac agggcttgta ccctgaagga cactgcacat     3180

gctatcattg cagctgaatt agatccagaa tttaataaac tttgtgagga aattaaggaa     3240

gcaagaataa aaagaggctt atcagtaaca tcagaacaaa taaatcctca tagtactgga     3300

gctcggaaga cagaaactag agtcgaagag gcatttcggc acaaacaaag aaatccaatg     3360

gatgtgtggc acaactctgc aaataaatgt gcatttcggg ttcggagaaa atcaaggcgg     3420

agatcacagt ggggtaaagg aattattaag aaaaggaaag ttaataattt aaaaaaagat     3480

gaagaagaca ccaaatttgc agactatgag aaccatacgg aggacaggaa attattagag     3540

aatggagagt ttgaggtaag cactgactgc catgaggaaa atggagaaga gactggagac     3600

ttatctatga ccaatgatga atcatcctgt gacatcatgg acttggacca ggggcagagg     3660

cttaacaatg gagcaggcac aaaagagaac tttgcatcta ctgaggagga aagttcaaat     3720

gaatctctac tggtcaacag cagcagttcc ttaaacccgg agcagacctc caggaaagag     3780

actttcctta aaggaaattg tctaaatggt gaggcttcca ctgacagttt tgaaggaata     3840

ccagttctgg aatgtcagaa tggcaagctt gaagtagttt ctttctgtga tagtggagat     3900

aaatgtagtt ctgaacaaaa gattcttctg gaggaccagt caaaagaaaa accagaaact     3960

tcgactgaaa atcatggaga tgatcttgag aaactagagg cactggaatg tagcaataat     4020

gagaagttag aacctggctc tgatgtggag gttaaagatg cagaactgga taaagaaggt     4080

gcttctaaag taaagaaata ccgtaaatta attttagagc aggcaaaaac gacaagcctg     4140

gaactggttc cagaagagcc atctgagcct gtgcctcctc ttatagttga tcgtgagaga     4200

ttgaagaaat tgcttgattt gttggtggat aaaagcaaca atctggcagt tgatcagctt     4260

gagagattat attctcttct tagtcagtgt atctaccgtc atcgtaaaga ttatgacaaa     4320

tcacaacttg tagaggagat ggaaagaaca gttcatatgt ttgagacatt cctatga        4377


<210>  211
<211>  2049
<212>  DNA
<213>  Homo sapiens;

<400>  211
atggcaagtc cagatagaag taaacggaag atattaaaag ccaaaaagac aatgccccta       60

agttgccgga agcaagtaga gatgctgaat aagtcaagga atgttgaagc gctgaaaaca      120

gcaattggga gtaatgttcc aagcggtaat cagagtttca gtcctagtgt cataactagg      180

acgactgaaa taaccaaatg tagcccttct gaaaatggtg catcctcatt ggactctaat      240

aaaaattcaa tatcagagaa aagtaaagta ttctctcaga attgcataaa accagtagaa      300

gaaattgttc attcagaaac aaaattggaa caagttgttt gttcgtacca aaagccaagt      360

agaacaacag aatcccccag cagagtcttc acagaagagg caaaagattc actgaacact      420

tctgaaaacg attctgagca tcagacaaat gtaacaagat ccctttttga gcatgagggg      480

gcttgtagtc taaagtccag ttgctgtcca cccagtgtat tgagtggtgt tgttcagatg      540

ccagagtcta cagtaaccag taccgtgggt gacaagaaaa ctgaccagat ggttttccat      600

ttagaaacaa actccaattc agaatcacat gataaaaggc aaagtgacaa cattttatgt      660

tcagaagact caggttttgt gcctgttgag aaaacaccta atttggtgaa ttcagtcact      720

tctaacaact gtgctgatga cattttgaaa actgatgagt gtagtagaac cagtatttca      780

aattgtgaaa gtgcagactc aacatggcag tcatcacttg acactaataa caacagccat      840

tatcaaaaga agaggatgtt ttcagaaaac gaggaaaatg ttaaacgcat gaaaacttca      900

gagcaaatta atgaaaatat ttgtgtaagt ttggaaaggc aaacagcatt cctggaacag      960

gtcagacatt tgattcagca ggagatctat agcataaatt atgaactatt tgataagaaa     1020

ctgaaagaat tgaaccaacg cattgggaag acagagtgca gaaataagca tgaaggaata     1080

gctgataaac ttttggcaaa aatagcaaaa cttcaaagac gtattaaaac agtattatta     1140

tttcaaagga attgtttgaa accaaacatg ttatccagta atggagcctc taaggttgca     1200

aattcagagg ctatgatttt ggataagaat cttgagtcag ttaatagtcc aattgaaaag     1260

tcttctgtga attatgagcc ttctaaccct tccgaaaaag gaagtaaaaa aattaatttg     1320

tcatcagatc aaaataagtc tgtttctgaa agtaacaatg atgatgttat gttgatttct     1380

gtggaaagtc ctaatttgac aactccaatt acatcaaatc caacagatac cagaaaaatt     1440

acatcaggaa attctagcaa ttctcccaat gctgaagtta tggctgtaca gaagaaactt     1500

gattctataa ttgatttgac aaaagaaggc ctatccaact gcaatacaga aagtccagta     1560

tcccccctgg agtcacattc gaaagctgct tcaaactcaa aggaaacaac cccattggca     1620

caaaatgcag tccaggttcc tgagtccttt gagcacctgc cacctctccc agaaccacca     1680

gcaccactac ctgaattagt agacaaaacc cgagacacac ttcctcccca gaagcctgag     1740

ctcaaagtga aacgggtttt cagacccaat ggcattgccc tgacttggaa tataaccaaa     1800

atcaatccca agtgtgctcc tgtagaaagc taccacctct tcctgtgtca tgagaactct     1860

aataataagt tgatttggaa gaagattgga gaaattaaag ctttaccact ccccatggcc     1920

tgtactttat ctcagttttt agcttccaac agatactatt ttactgtcca atcaaaagat     1980

atttttggac gatatggacc attctgtgat ataaaatcta tccctgggtt ttctgaaaat     2040

cttacgtaa                                                             2049


<210>  212
<211>  9171
<212>  DNA
<213>  Homo sapiens;

<400>  212
atgagtctag tacttaatga tctgcttatc tgctgccgtc aactagaaca tgatagagct       60

acagaacgaa agaaagaagt tgagaaattt aagcgcctga ttcgagatcc tgaaacaatt      120

aaacatctag atcggcattc agattccaaa caaggaaaat atttgaattg ggatgctgtt      180

tttagatttt tacagaaata tattcagaaa gaaacagaat gtctgagaat agcaaaacca      240

aatgtatcag cctcaacaca agcctccagg cagaaaaaga tgcaggaaat cagtagtttg      300

gtcaaatact tcatcaaatg tgcaaacaga agagcaccta ggctaaaatg tcaagaactc      360

ttaaattata tcatggatac agtgaaagat tcatctaatg gtgctattta cggagctgat      420

tgtagcaaca tactactcaa agacattctt tctgtgagaa aatactggtg tgaaatatct      480

cagcaacagt ggttagaatt gttctctgtg tacttcaggc tctatctgaa accttcacaa      540

gatgttcata gagttttagt ggctagaata attcatgctg ttaccaaagg atgctgttct      600

cagactgacg gattaaattc caaatttttg gacttttttt ccaaggctat tcagtgtgcg      660

agacaagaaa agagctcttc aggtctaaat catatcttag cagctcttac tatcttcctc      720

aagactttgg ctgtcaactt tcgaattcga gtgtgtgaat taggagatga aattcttccc      780

actttgcttt atatttggac tcaacatagg cttaatgatt ctttaaaaga agtcattatt      840

gaattatttc aactgcaaat ttatatccat catccgaaag gagccaaaac ccaagaaaaa      900

ggtgcttatg aatcaacaaa atggagaagt attttataca acttatatga tctgctagtg      960

aatgagataa gtcatatagg aagtagagga aagtattctt caggatttcg taatattgcc     1020

gtcaaagaaa atttgattga attgatggca gatatctgtc accaggtttt taatgaagat     1080

accagatcct tggagatttc tcaatcttac actactacac aaagagaatc tagtgattac     1140

agtgtccctt gcaaaaggaa gaaaatagaa ctaggctggg aagtaataaa agatcacctt     1200

cagaagtcac agaatgattt tgatcttgtg ccttggctac agattgcaac ccaattaata     1260

tcaaagtatc ctgcaagttt acctaactgt gagctgtctc cattactgat gatactatct     1320

cagcttctac cccaacagcg acatggggaa cgtacaccat atgtgttacg atgccttacg     1380

gaagttgcat tgtgtcaaga caagaggtca aacctagaaa gctcacaaaa gtcagattta     1440

ttaaaactct ggaataaaat ttggtgtatt acctttcgtg gtataagttc tgagcaaata     1500

caagctgaaa actttggctt acttggagcc ataattcagg gtagtttagt tgaggttgac     1560

agagaattct ggaagttatt tactgggtca gcctgcagac cttcatgtcc tgcagtatgc     1620

tgtttgactt tggcactgac caccagtata gttccaggaa cggtaaaaat gggaatagag     1680

caaaatatgt gtgaagtaaa tagaagcttt tctttaaagg aatcaataat gaaatggctc     1740

ttattctatc agttagaggg tgacttagaa aatagcacag aagtgcctcc aattcttcac     1800

agtaattttc ctcatcttgt actggagaaa attcttgtga gtctcactat gaaaaactgt     1860

aaagctgcaa tgaatttttt ccaaagcgtg ccagaatgtg aacaccacca aaaagataaa     1920

gaagaacttt cattctcaga agtagaagaa ctatttcttc agacaacttt tgacaagatg     1980

gactttttaa ccattgtgag agaatgtggt atagaaaagc accagtccag tattggcttc     2040

tctgtccacc agaatctcaa ggaatcactg gatcgctgtc ttctgggatt atcagaacag     2100

cttctgaata attactcatc tgagattaca aattcagaaa ctcttgtccg gtgttcacgt     2160

cttttggtgg gtgtccttgg ctgctactgt tacatgggtg taatagctga agaggaagca     2220

tataagtcag aattattcca gaaagccaag tctctaatgc aatgtgcagg agaaagtatc     2280

actctgttta aaaataagac aaatgaggaa ttcagaattg gttccttgag aaatatgatg     2340

cagctatgta cacgttgctt gagcaactgt accaagaaga gtccaaataa gattgcatct     2400

ggctttttcc tgcgattgtt aacatcaaag ctaatgaatg acattgcaga tatttgtaaa     2460

agtttagcat ccttcatcaa aaagccattt gaccgtggag aagtagaatc aatggaagat     2520

gatactaatg gaaatctaat ggaggtggag gatcagtcat ccatgaatct atttaacgat     2580

taccctgata gtagtgttag tgatgcaaac gaacctggag agagccaaag taccataggt     2640

gccattaatc ctttagctga agaatatctg tcaaagcaag atctactttt cttagacatg     2700

ctcaagttct tgtgtttgtg tgtaactact gctcagacca atactgtgtc ctttagggca     2760

gctgatattc ggaggaaatt gttaatgtta attgattcta gcacgctaga acctaccaaa     2820

tccctccacc tgcatatgta tctaatgctt ttaaaggagc ttcctggaga agagtacccc     2880

ttgccaatgg aagatgttct tgaacttctg aaaccactat ccaatgtgtg ttctttgtat     2940

cgtcgtgacc aagatgtttg taaaactatt ttaaaccatg tccttcatgt agtgaaaaac     3000

ctaggtcaaa gcaatatgga ctctgagaac acaagggatg ctcaaggaca gtttcttaca     3060

gtaattggag cattttggca tctaacaaag gagaggaaat atatattctc tgtaagaatg     3120

gccctagtaa attgccttaa aactttgctt gaggctgatc cttattcaaa atgggccatt     3180

cttaatgtaa tgggaaaaga ctttcctgta aatgaagtat ttacacaatt tcttgctgac     3240

aatcatcacc aagttcgcat gttggctgca gagtcaatca atagattgtt ccaggacacg     3300

aagggagatt cttccaggtt actgaaagca cttcctttga agcttcagca aacagctttt     3360

gaaaatgcat acttgaaagc tcaggaagga atgagagaaa tgtcccatag tgctgagaac     3420

cctgaaactt tggatgaaat ttataataga aaatctgttt tactgacgtt gatagctgtg     3480

gttttatcct gtagccctat ctgcgaaaaa caggctttgt ttgccctgtg taaatctgtg     3540

aaagagaatg gattagaacc tcaccttgtg aaaaaggttt tagagaaagt ttctgaaact     3600

tttggatata gacgtttaga agactttatg gcatctcatt tagattatct ggttttggaa     3660

tggctaaatc ttcaagatac tgaatacaac ttatcttctt ttccttttat tttattaaac     3720

tacacaaata ttgaggattt ctatagatct tgttataagg ttttgattcc acatctggtg     3780

attagaagtc attttgatga ggtgaagtcc attgctaatc agattcaaga ggactggaaa     3840

agtcttctaa cagactgctt tccaaagatt cttgtaaata ttcttcctta ttttgcctat     3900

gagggtacca gagacagtgg gatggcacag caaagagaga ctgctaccaa ggtctatgat     3960

atgcttaaaa gtgaaaactt attgggaaaa cagattgatc acttattcat tagtaattta     4020

ccagagattg tggtggagtt attgatgacg ttacatgagc cagcaaattc tagtgccagt     4080

cagagcactg acctctgtga cttttcaggg gatttggatc ctgctcctaa tccacctcat     4140

tttccatcgc atgtgattaa agcaacattt gcctatatca gcaattgtca taaaaccaag     4200

ttaaaaagca ttttagaaat tctttccaaa agccctgatt cctatcagaa aattcttctt     4260

gccatatgtg agcaagcagc tgaaacaaat aatgtttata agaagcacag aattcttaaa     4320

atatatcacc tgtttgttag tttattactg aaagatataa aaagtggctt aggaggagct     4380

tgggcctttg ttcttcgaga cgttatttat actttgattc actatatcaa ccaaaggcct     4440

tcttgtatca tggatgtgtc attacgtagc ttctcccttt gttgtgactt attaagtcag     4500

gtttgccaga cagccgtgac ttactgtaag gatgctctag aaaaccatct tcatgttatt     4560

gttggtacac ttatacccct tgtgtatgag caggtggagg ttcagaaaca ggtattggac     4620

ttgttgaaat acttagtgat agataacaag gataatgaaa acctctatat cacgattaag     4680

cttttagatc cttttcctga ccatgttgtt tttaaggatt tgcgtattac tcagcaaaaa     4740

atcaaataca gtagaggacc cttttcactc ttggaggaaa ttaaccattt tctctcagta     4800

agtgtttatg atgcacttcc attgacaaga cttgaaggac taaaggatct tcgaagacaa     4860

ctggaactac ataaagatca gatggtggac attatgagag cttctcagga taatccgcaa     4920

gatgggatta tggtgaaact agttgtcaat ttgttgcagt tatccaagat ggcaataaac     4980

cacactggtg aaaaagaagt tctagaggct gttggaagct gcttgggaga agtgggtcct     5040

atagatttct ctaccatagc tatacaacat agtaaagatg catcttatac caaggccctt     5100

aagttatttg aagataaaga acttcagtgg accttcataa tgctgaccta cctgaataac     5160

acactggtag aagattgtgt caaagttcga tcagcagctg ttacctgttt gaaaaacatt     5220

ttagccacaa agactggaca tagtttctgg gagatttata agatgacaac agatccaatg     5280

ctggcctatc tacagccttt tagaacatca agaaaaaagt ttttagaagt acccagattt     5340

gacaaagaaa acccttttga aggcctggat gatataaatc tgtggattcc tctaagtgaa     5400

aatcatgaca tttggataaa gacactgact tgtgcttttt tggacagtgg aggcacaaaa     5460

tgtgaaattc ttcaattatt aaagccaatg tgtgaagtga aaactgactt ttgtcagact     5520

gtacttccat acttgattca tgatatttta ctccaagata caaatgaatc atggagaaat     5580

ctgctttcta cacatgttca gggatttttc accagctgtc ttcgacactt ctcgcaaacg     5640

agccgatcca caacccctgc aaacttggat tcagagtcag agcacttttt ccgatgctgt     5700

ttggataaaa aatcacaaag aacaatgctt gctgttgtgg actacatgag aagacaaaag     5760

agaccttctt caggaacaat ttttaatgat gctttctggc tggatttaaa ttatctagaa     5820

gttgccaagg tagctcagtc ttgtgctgct cactttacag ctttactcta tgcagaaatc     5880

tatgcagata agaaaagtat ggatgatcaa gagaaaagaa gtcttgcatt tgaagaagga     5940

agccagagta caactatttc tagcttgagt gaaaaaagta aagaagaaac tggaataagt     6000

ttacaggatc ttctcttaga aatctacaga agtatagggg agccagatag tttgtatggc     6060

tgtggtggag ggaagatgtt acaacccatt actagactac gaacatatga acacgaagca     6120

atgtggggca aagccctagt aacatatgac ctcgaaacag caatcccctc atcaacacgc     6180

caggcaggaa tcattcaggc cttgcagaat ttgggactct gccatattct ttccgtctat     6240

ttaaaaggat tggattatga aaataaagac tggtgtcctg aactagaaga acttcattac     6300

caagcagcat ggaggaatat gcagtgggac cattgcactt ccgtcagcaa agaagtagaa     6360

ggaaccagtt accatgaatc attgtacaat gctctacaat ctctaagaga cagagaattc     6420

tctacatttt atgaaagtct caaatatgcc agagtaaaag aagtggaaga gatgtgtaag     6480

cgcagccttg agtctgtgta ttcgctctat cccacactta gcaggttgca ggccattgga     6540

gagctggaaa gcattgggga gcttttctca agatcagtca cacatagaca actctctgaa     6600

gtatatatta agtggcagaa acactcccag cttctcaagg acagtgattt tagttttcag     6660

gagcctatca tggctctacg cacagtcatt ttggagatcc tgatggaaaa ggaaatggac     6720

aactcacaaa gagaatgtat taaggacatt ctcaccaaac accttgtaga actctctata     6780

ctggccagaa ctttcaagaa cactcagctc cctgaaaggg caatatttca aattaaacag     6840

tacaattcag ttagctgtgg agtctctgag tggcagctgg aagaagcaca agtattctgg     6900

gcaaaaaagg agcagagtct tgccctgagt attctcaagc aaatgatcaa gaagttggat     6960

gccagctgtg cagcgaacaa tcccagccta aaacttacat acacagaatg tctgagggtt     7020

tgtggcaact ggttagcaga aacgtgctta gaaaatcctg cggtcatcat gcagacctat     7080

ctagaaaagg cagtagaagt tgctggaaat tatgatggag aaagtagtga tgagctaaga     7140

aatggaaaaa tgaaggcatt tctctcatta gcccggtttt cagatactca ataccaaaga     7200

attgaaaact acatgaaatc atcggaattt gaaaacaagc aagctctcct gaaaagagcc     7260

aaagaggaag taggtctcct tagggaacat aaaattcaga caaacagata cacagtaaag     7320

gttcagcgag agctggagtt ggatgaatta gccctgcgtg cactgaaaga ggatcgtaaa     7380

cgcttcttat gtaaagcagt tgaaaattat atcaactgct tattaagtgg agaagaacat     7440

gatatgtggg tattccgact ttgttccctc tggcttgaaa attctggagt ttctgaagtc     7500

aatggcatga tgaagagaga cggaatgaag attccaacat ataaattttt gcctcttatg     7560

taccaattgg ctgctagaat ggggaccaag atgatgggag gcctaggatt tcatgaagtc     7620

ctcaataatc taatctctag aatttcaatg gatcaccccc atcacacttt gtttattata     7680

ctggccttag caaatgcaaa cagagatgaa tttctgacta aaccagaggt agccagaaga     7740

agcagaataa ctaaaaatgt gcctaaacaa agctctcagc ttgatgagga tcgaacagag     7800

gctgcaaata gaataatatg tactatcaga agtaggagac ctcagatggt cagaagtgtt     7860

gaggcacttt gtgatgctta tattatatta gcaaacttag atgccactca gtggaagact     7920

cagagaaaag gcataaatat tccagcagac cagccaatta ctaaacttaa gaatttagaa     7980

gatgttgttg tccctactat ggaaattaag gtggaccaca caggagaata tggaaatctg     8040

gtgactatac agtcatttaa agcagaattt cgcttagcag gaggtgtaaa tttaccaaaa     8100

ataatagatt gtgtaggttc cgatggcaag gagaggagac agcttgttaa gggccgtgat     8160

gacctgagac aagatgctgt catgcaacag gtcttccaga tgtgtaatac attactgcag     8220

agaaacacgg aaactaggaa gaggaaatta actatctgta cttataaggt ggttcccctc     8280

tctcagcgaa gtggtgttct tgaatggtgc acaggaactg tccccattgg tgaatttctt     8340

gttaacaatg aagatggtgc tcataaaaga tacaggccaa atgatttcag tgcctttcag     8400

tgccaaaaga aaatgatgga ggtgcaaaaa aagtcttttg aagagaaata tgaagtcttc     8460

atggatgttt gccaaaattt tcaaccagtt ttccgttact tctgcatgga aaaattcttg     8520

gatccagcta tttggtttga gaagcgattg gcttatacgc gcagtgtagc tacttcttct     8580

attgttggtt acatacttgg acttggtgat agacatgtac agaatatctt gataaatgag     8640

cagtcagcag aacttgtaca tatagatcta ggtgttgctt ttgaacaggg caaaatcctt     8700

cctactcctg agacagttcc ttttagactc accagagata ttgtggatgg catgggcatt     8760

acgggtgttg aaggtgtctt cagaagatgc tgtgagaaaa ccatggaagt gatgagaaac     8820

tctcaggaaa ctctgttaac cattgtagag gtccttctat atgatccact ctttgactgg     8880

accatgaatc ctttgaaagc tttgtattta cagcagaggc cggaagatga aactgagctt     8940

caccctactc tgaatgcaga tgaccaagaa tgcaaacgaa atctcagtga tattgaccag     9000

agtttcaaca aagtagctga acgtgtctta atgagactac aagagaaact gaaaggagtg     9060

gaagaaggca ctgtgctcag tgttggtgga caagtgaatt tgctcataca gcaggccata     9120

gaccccaaaa atctcagccg acttttccca ggatggaaag cttgggtgtg a              9171


<210>  213
<211>  1536
<212>  DNA
<213>  Homo sapiens;

<400>  213
atggcgctgc gggcgatgcg ggggattgtc aacggggccg cacccgagct acccgtgccc       60

accggtgggc cggcggtggg agctcgggag caggcgctgg cagtcagtcg gaactacctc      120

tcccagcctc gcctcacata caagacagta tctggagtca atggtccact agtgatctta      180

gatcatgtta agtttcccag gtatgctgaa attgtccatt tgaccttacc ggatggcaca      240

aagagaagtg ggcaagttct ggaagttagt ggttccaagg cagtagttca ggtatttgaa      300

gggacttcag gtatagatgc taagaaaacg tcctgtgagt ttactgggga tattctccga      360

acaccggtgt ctgaggatat gcttggtcgg gtattcaatg gatcgggaaa acccattgac      420

agaggtcctg ttgtactggc cgaagacttc cttgatatca tgggtcagcc aatcaaccct      480

caatgtcgaa tctacccaga ggaaatgatt cagactggca tttcggccat cgatgggatg      540

aacagtattg ctagggggca gaaaattcct atcttctctg ctgctgggct accacacaat      600

gagattgcag ctcagatctg tcgccaggct ggtttggtaa agaaatccaa agatgtagta      660

gactacagtg aggaaaattt tgcaattgta tttgctgcta tgggtgtaaa catggaaact      720

gcccggttct tcaaatctga ctttgaagaa aatggctcaa tggacaatgt ctgcctcttt      780

ttgaacttgg ctaatgaccc aaccattgag cgaattatca ctcctcgcct ggctctaacc      840

acagctgaat ttctggcgta ccaatgtgag aaacatgtat tggttattct aacagacatg      900

agttcttatg ctgaagcact tcgagaggtt tcagcagcca gggaagaggt acctggtcga      960

cgaggttttc caggttacat gtatacagat ttagccacga tatatgaacg cgctgggcga     1020

gtggaaggga gaaacggctc gattactcaa atccctattc taaccatgcc taatgatgat     1080

atcactcacc ccatcccaga cttgactggc tacattacag aggggcagat ctatgtggac     1140

agacagctgc acaacagaca gatttatcca cctatcaatg tgctgccctc actatcacgg     1200

ttaatgaagt ctgctattgg agaagggatg accaggaagg atcatgccga tgtatctaac     1260

cagctatatg cgtgctatgc tattggaaag gatgtgcaag ccatgaaagc tgtcgttgga     1320

gaagaagccc ttacctcaga tgatcttctc tacttggaat ttctgcagaa gtttgagagg     1380

aacttcattg ctcagggtcc ttacgaaaat cgcactgtct ttgagacttt ggacattggc     1440

tggcagctac tccgaatctt ccccaaagaa atgctgaaga gaatccctca gagcaccctc     1500

agcgaatttt accctcgaga ctctgcaaag cattag                               1536


<210>  214
<211>  2211
<212>  DNA
<213>  Homo sapiens;

<400>  214
atgtctctga gtgagaactc ggtttttgcc tatgaatctt ctgtgcatag caccaatgtt       60

ttactcagcc ttaatgacca gcggaagaaa gatgtgctgt gcgatgtcac catctttgtg      120

gagggacagc ggttccgcgc tcaccggtcc gtgctggcgg catgcagcag ttacttccac      180

tcaagaatcg taggccaggc tgatggagag ctgaacatta ctcttccaga agaggtgaca      240

gttaaaggat ttgaaccttt aattcagttt gcctacactg ctaaactgat tttaagtaaa      300

gagaatgtgg atgaagtgtg caaatgtgtg gagtttttaa gtgtacataa tattgaggaa      360

tcctgctttc agtttctgaa atttaagttt ttggactcca ctgcagacca gcaagaatgc      420

ccaagaaaaa aatgcttttc atcacactgt cagaaaacag accttaaact ttcacttttg      480

gaccagaggg atctagaaac tgatgaagtg gaggaatttc tggaaaataa aaatgttcag      540

actcctcagt gtaaactccg caggtatcaa ggaaatgcaa aagcctcacc tcctctacaa      600

gacagtgcca gtcagacata tgagtccatg tgcttagaga aggatgctgc tctggccttg      660

ccttctttat gccccaaata cagaaaattc caaaaagcat ttggaactga cagagtccgt      720

actggggaat ctagtgtcaa agacattcat gcttctgttc agccaaatga aaggtctgaa      780

aatgaatgcc tgggaggagt cccggagtgt agagatttgc aggtgatgtt aaaatgtgac      840

gaaagtaaat tagcaatgga acctgaagaa acgaagaaag atcctgcttc tcagtgccca      900

actgaaaaat cagaagtgac tcctttcccc cacaattctt ccatagaccc tcatggactt      960

tattctttgt ctcttttaca cacatatgac caatatggtg acttgaattt tgctggtatg     1020

caaaacacaa cagtgttaac agaaaagcct ttgtcaggta cagacgtcca agaaaaaaca     1080

tttggtgaaa gtcaggattt acctttgaaa tccgacttgg gcaccaggga agatagtagt     1140

gttgcatcta gtgataggag tagtgtggag cgagaagtgg cagaacacct agcaaaaggc     1200

ttctggagtg acatttgcag cacggacact ccttgccaaa tgcagttatc acctgctgtg     1260

gccaaagatg gctcagaaca gatctcacag aaacggtctg agtgtccgtg gttaggtatc     1320

aggattagtg agagcccaga accaggtcaa aggactttca caacattaag ttctgtcaac     1380

tgccctttta taagtactct gagtactgaa ggctgttcaa gcaatttgga aattggaaac     1440

gatgattatg tttcagaacc ccagcaagaa ccttgcccat atgcttgtgt cattagcttg     1500

ggagacgact ctgagacgga caccgaagga gacagtgaat cctgttcagc cagagaacaa     1560

gaatgtgagg taaaactgcc attcaatgca caacggataa tttcactgtc tcgaaatgat     1620

tttcagtcct tgttgaaaat gcacaagctt actccagaac agctggattg tatccatgat     1680

attcgaagaa gaagtaaaaa cagaattgct gcacagcgct gtcgcaagag aaaacttgac     1740

tgtatacaga atcttgaatc agaaattgag aagctgcaaa gtgaaaagga gagcttgttg     1800

aaggaaagag atcacatttt gtcaactctg ggtgagacaa agcagaacct aactggactt     1860

tgccagaaag tttgtaaaga agcagctctg agtcaagaac aaatacagat actcgccaag     1920

tactcagctg cagattgccc actttcattt ttaatttctg aaaaagataa aagtactcct     1980

gatggtgaac tggcgttacc atcaattttc agtttatctg accggcctcc agcagtgctg     2040

cctccctgtg ccagaggaaa cagtgagcct ggctacgcgc gagggcagga gtcccagcag     2100

atgtccacag ccacctctga gcaagctggg cctgcggaac agtgtcgtca gagtggtggg     2160

atctcagatt tctgtcagca gatgactgat aaatgtacta ctgatgagta a              2211


<210>  215
<211>  1410
<212>  DNA
<213>  Homo sapiens;

<400>  215
atgatgtcgg aacacgacct ggccgatgtg gttcagattg cagtggaaga cctgagccct       60

gaccacccag ttgttttgga gaatcatgta gtgacagatg aagacgaacc tgctttgaaa      120

cgccagcgac tagaaatcaa ttgccaggat ccatctataa agtcattcct gtattccatc      180

aaccagacaa tctgcttgcg gttggatagc attgaagcca aattgcaagc cctggaggct      240

acttgtaaat ccttagaaga aaagctggat ctggtcacga acaagcagca cagccccatc      300

caggtcccca tggtggccgg ctcccctctc ggggcaaccc agacgtgcaa caaagtgcga      360

tgcgctgtgc ctgggcgtcg gcagaacacc attgtggtga aggtgccggg ccaagaagac      420

agccaccacg aggacgggga gagcggctcg gaggccagcg actctgtgtc cagctgtggg      480

caggcgggca gtcagagcat cgggagcaac gtcacgctca tcaccctgaa ctcggaagag      540

gactacccca atggcacctg gctgggcgac gagaacaacc ccgagatgcg ggtacgctgc      600

gccatcatcc cctccgacat gctgcacatc agcaccaact gccgcacggc cgagaagatg      660

gcgctcacgc tgctggacta cctcttccac cgcgaggtgc aggctgtgtc caacctctcg      720

gggcagggca agcacgggaa gaagcagctg gacccgctca ccatctacgg catccggtgt      780

caccttttct ataaatttgg catcacagaa tccgactggt accgaatcaa gcagagcatc      840

gactccaagt gccgcacggc gtggcggcgc aagcagcggg gccagagcct ggcggtcaag      900

agcttctcgc ggagaacgcc caactcgtcc tcctactgcc cttcagagcc gatgatgagc      960

accccacctc ctgccagcga gctcccgcag ccacagccgc agccgcaggc cctgcactac     1020

gcgctggcca acgcacagca ggtgcagatc caccagatcg gagaagacgg acaggtgcaa     1080

gtaatcccac agggacacct ccacatcgcc caggtgccgc agggggagca agtccagatc     1140

acgcaggaca gcgagggcaa cctccagatc catcacgtgg ggcaggacgg tcaggtgctg     1200

cagggtgcac agctgatcgc cgtggcctcc tcggaccccg cggcggcggg cgtggatggg     1260

tcgccactcc agggcagcga catccaggtt cagtacgtgc agctggcgcc agtgagtgac     1320

cacacggccg gggcacagac ggccgaagcc ctgcagccca cgctacagcc ggagatgcag     1380

ctcgagcacg gggccatcca gattcagtga                                      1410


<210>  216
<211>  6507
<212>  DNA
<213>  Homo sapiens;

<400>  216
atggagtctg gagaacggtt accatcctca gcagcctcct ctactacacc aacttcatct       60

tcgacacctt ctgtggcttc agtagtttca aaaggtggcc tttccactgg agttgcttca      120

cttagctcta caatcaaccc atgtggacat ttattcagaa cagctgggga tcaaccgttt      180

aacctgtcca cagtgtcgag tgccttccca atggtcagcc acccagtctt tggtctacat      240

tcagccagct cagggcattc agaatttggt ggtttgggga cacttggtac acccacagcc      300

ttagccgcac atccccaact agcatctttt ccaggtgcag aatggtggcg aacaactgat      360

gctcatactc gtacaggagc aaccttcttt ccaccattac tgggaattcc accactattt      420

gctcccccag cccagaatca tgattcttct tcattccatt caaggacttc gggaaaaagt      480

aatcgaaatg gtcccgaaaa aggtgtaaat gggtcaataa atggaagtaa tacatcatct      540

gtaattggta tcaacacatc tgtactatcc actactgctt caagttccat gggacaaact      600

aaaagtacaa gctcaggtgg aggaaatcga aaatgtaatc aggaacaaag caaaaaccag      660

cctttggatg ctagagttga caaaatcaaa gataagaaac caaggaagaa agcaatggaa      720

agttctagca acagtgatag tgattcaggc acatcatcag acacctcaag tgaaggcatt      780

agtagcagtg attcagatga tctagaagaa gatgaagaag aagaagatca aagtattgaa      840

gaaagtgaag atgatgattc tgattcagag agtgaagcac aacataaaag taacaaccag      900

gtgctattac atggtatttc agacccaaaa gcagatggac agaaagcaac tgaaaaagcc      960

caggaaaaaa gaatacacca gccattacct cttgcgtctg aatcccagac tcactcattc     1020

caatcccagc agaagcagcc tcaggttttg tcacagcagc ttccatttat tttccaaagc     1080

tctcaggcaa aggaggaatc tgtgaacaaa cacaccagtg taatacagtc tacgggattg     1140

gtgtccaatg tgaaaccttt atctttggta aatcaagcca aaaaggaaac ttacatgaaa     1200

ctcatagttc cttctcctga tgttcttaaa gcagggaata aaaatacctc tgaagaatct     1260

agtttattga ccagtgaatt gagatccaaa cgggaacaat ataaacaggc attcccatca     1320

cagttaaaga aacaagagtc atcgaagagc ctgaagaagg ttattgcagc tttgtcaaat     1380

ccaaaagcaa cctctagttc accagcacat ccaaaacaaa cattagaaaa caaccaccca     1440

aatccattct tgacaaatgc acttttaggt aatcaccaac caaatggagt tattcaaagt     1500

gtcattcaag aagctcctct agcacttact accaaaacta aaatgcagag caagattaat     1560

gaaaacattg ctgctgcaag tagcacccct ttttcctcac ctgtaaatct gagtacaagt     1620

gggagaagaa cccctggcaa tcagacacct gtaatgccct ctgcctctcc catcctgcat     1680

agtcaaggga aggaaaaagc agttagcaat aatgtaaacc cagtaaaaac acagcatcac     1740

tcccatcctg caaaatcttt agtggaacaa ttcagaggaa cagattcaga cattcccagt     1800

agtaaagatt ctgaagattc aaatgaggat gaagaggaag atgatgaaga agaagatgag     1860

gaagatgatg aagatgatga atctgatgac agccaatcag aatcagatag taattcagaa     1920

tcagatacag aaggatcaga agaagaagat gatgatgata aagaccaaga tgaatcagat     1980

agtgatactg aaggagagaa aacttcaatg aaactgaata aaacaacttc ctctgtcaaa     2040

agcccttcca tgagtctcac aggtcactca acacctcgta acctccacat agcaaaagcc     2100

ccaggctctg ctcctgctgc cttatgttct gaatcccagt cacctgcttt tcttggtaca     2160

tcttcttcca cacttacttc aagcccacac tctggcactt ccaaaagaag aagagtaaca     2220

gatgaacgtg aactgcgtat tccattggaa tatggctggc agagagagac aagaataaga     2280

aactttggag ggcgccttca aggagaagta gcatattatg ctccatgtgg aaagaaactt     2340

aggcagtacc ctgaagtaat aaagtatctc agcagaaatg gaataatgga tatctcaagg     2400

gacaatttca gcttcagtgc aaaaataaga gtgggtgact tctatgaagc cagagatgga     2460

ccgcagggaa tgcagtggtg tcttttgaaa gaagaggatg tcattcctcg tatcagggca     2520

atggaaggtc gtagaggaag accaccaaat ccagatagac aacgagcaag agaggaatcc     2580

aggatgagac gtcggaaagg tcgacctcca aatgttggca atgctgaatt cctagataac     2640

gcagatgcaa agttgctaag aaaactgcaa gctcaagaaa tagccaggca agcagcacaa     2700

ataaagcttt tgagaaaact tcaaaagcag gaacaggctc gggttgctaa agaagccaaa     2760

aaacaacaag caataatggc tgctgaggag aagcggaagc aaaaagaaca gataaagatt     2820

atgaaacagc aggaaaaaat taagagaata cagcaaatca gaatggaaaa agaacttcga     2880

gctcagcaaa ttctagaggc taaaaagaaa aagaaggaag aagcggcaaa tgccaaatta     2940

ttggaggccg agaaacgaat aaaggaaaaa gaaatgagaa gacaacaagc tgttcttctg     3000

aaacatcagg aacgagagcg aaggcgacaa cacatgatgc ttatgaaagc tatggaagct     3060

cgtaaaaaag cagaagaaaa agagcggttg aaacaagaaa aacgtgatga gaaaagatta     3120

aataaagagc gtaaactaga gcagcgaaga ttagaattag aaatggcaaa ggaactaaag     3180

aagcctaatg aagacatgtg cttagcagac caaaagcctt tgccagagtt gcctcgtatt     3240

ccaggacttg ttctctctgg aagtacattt tcagactgtc tcatggtggt gcagttctta     3300

cgaaactttg gtaaagtttt gggctttgat gtgaatattg atgttccaaa cctgagtgtt     3360

cttcaagagg gattgctaaa tataggggac agcatgggtg aagtacaaga cttgcttgtg     3420

aggctcctct cagctgctgt atgtgatcca ggtctaataa caggatacaa ggctaaaaca     3480

gctcttggag aacatttgct gaatgttggt gtgaatcgag acaatgtttc cgagatttta     3540

cagatattta tggaagccca ctgtggacaa actgagctta ctgaaagtct gaagaccaaa     3600

gcttttcagg ctcacactcc agcacagaaa gcttcagtcc tggctttcct gatcaatgaa     3660

ctggcatgca gcaagagtgt ggtcagtgaa atcgacaaga acattgatta tatgtcaaac     3720

ttgaggagag ataaatgggt ggtagaaggt aaactccgca agctcagaat cattcatgct     3780

aagaaaacag gcaaaagaga cacttcaggt ggcattgatc tgggagaaga gcagcatccc     3840

ttgggcacac ccactccagg acgcaagcga agaaggaagg gaggagacag tgattatgac     3900

gatgatgatg acgatgacag tgatgaccaa ggggatgaag atgatgagga tgaagaagat     3960

aaagaagaca aaaaaggaaa aaagactgat atctgtgaag atgaggatga aggtgaccaa     4020

gcagcaagtg ttgaagagct ggaaaaacag attgaaaaac tgagtaaaca acagagtcag     4080

tacagaagga agctctttga tgcgtctcac tcattgcgtt cagtgatgtt tggccaagat     4140

cgttacagac gccggtactg gattcttccc caatgtgggg ggatttttgt agaaggcatg     4200

gagagtggtg aaggactaga agaaattgca aaagaaagag aaaaactgaa aaaggcagaa     4260

agtgtccaga tcaaagaaga aatgtttgag acttctgggg acagtttaaa ttgttcaaat     4320

acagatcact gtgaacaaaa ggaagatctt aaagaaaaag ataacacaaa tctattcctt     4380

cagaaacctg gctctttttc caaattaagc aagcttttgg aagtagctaa gatgcctcct     4440

gagtcagagg ttatgacccc caaaccaaat gctggtgcaa atgggtgcac gttgtcttat     4500

cagaacagtg gaaaacattc actgggcagc gttcagtcaa cagcaacgca aagcaatgtg     4560

gaaaaggcag actctaataa tctgtttaat actggttcaa gtggtccagg gaagttctac     4620

agtcctctcc ccaatgacca gttactaaaa acgctgactg aaaagaatag acaatggttt     4680

agtcttttgc cacgaacacc ctgtgatgac acttcactta ctcatgccga tatgtcaact     4740

gcttctttgg tgactcctca gtctcagcca ccatctaagt caccttcacc taccccagct     4800

cctcttggat cttctgctca gaatcctgtt ggcttaaatc catttgcttt atcacctctt     4860

caggtgaaag gtggagtatc tatgatggga cttcagtttt gtggatggcc cactggtgtg     4920

gttacttcta atattccatt tacatcatct gtacctagtc taggatcggg gttagggtta     4980

tcagaaggaa atggtaattc attcttgact tccaatgttg cttcaagtaa aagtgaatct     5040

ccagtaccac agaatgaaaa ggccacttca gctcaacctg cagctgttga agtagcaaaa     5100

ccagtagatt ttcctagtcc aaaacctatt ccagaagaaa tgcagtttgg ttggtggaga     5160

attattgacc cagaggacct aaaagctttg ctcaaagtgc tgcatctcag aggaataaga     5220

gaaaaggcat tacaaaaaca aattcagaaa catttggatt atattactca agcctgcctc     5280

aagaataagg atgttgctat tattgaactg aatgaaaatg aagaaaacca agtaactcga     5340

gatattgtgg agaactggtc agtagaagaa caagcaatgg aaatggattt gagtgtcctt     5400

caacaggtag aagatctaga aaggagagtt gcatcagcaa gtttgcaagt gaagggttgg     5460

atgtgtccag agcctgcatc agaaagggag gacttggtat attttgaaca taaatcattt     5520

actaaattgt gcaaggagca tgatggagaa tttactggcg aagacgaaag cagtgcacat     5580

gcactagaac ggaagagtga caacccccta gatatagctg taaccaggct ggctgatttg     5640

gagcggaaca ttgaaagaag aattgaagag gatattgctc cagggctcag ggtatggaga     5700

agggcattat cagaagctcg cagtgctgca caggtagctc tgtgcattca gcaattacag     5760

aaatcaatag catgggaaaa atcaattatg aaagtttact gccaaatctg tcgaaaggga     5820

gataatgaag aactgcttct tctttgtgat ggctgtgaca aaggctgtca tacctactgc     5880

catagaccca agattacaac aatcccagat ggagactggt tttgtccagc ttgcattgct     5940

aaggcaagtg gtcaaactct aaaaatcaaa aaacttcatg tcaaaggaaa aaagactaat     6000

gagtcaaaga aaggcaagaa ggtaacttta acaggagata ctgaagatga agactctgca     6060

tctacaagta gttcactaaa aagaggaaac aaagacctca agaaaagaaa aatggaggaa     6120

aacacttcta ttaacttgtc aaaacaagaa agttttactt cagttaagaa acctaaaaga     6180

gatgactcca aggacctagc tctttgcagt atgattctga ctgaaatgga aactcatgag     6240

gatgcatggc cttttctact tcctgtaaac ttgaaacttg ttcctggtta taagaaagtt     6300

attaagaagc ctatggattt ttccacaatt agagagaaac taagtagtgg acagtatcca     6360

aaccttgaaa cctttgctct agatgtcagg cttgtttttg acaactgtga aacatttaat     6420

gaagatgatt ctgatatagg cagagctggc cacaatatga ggaagtattt tgaaaaaaag     6480

tggacagata ctttcaaagt gagctga                                         6507


<210>  217
<211>  720
<212>  DNA
<213>  Homo sapiens;

<400>  217
atggcgcacg ctgggagaac agggtacgat aaccgggaga tagtgatgaa gtacatccat       60

tataagctgt cgcagagggg ctacgagtgg gatgcgggag atgtgggcgc cgcgcccccg      120

ggggccgccc ccgcaccggg catcttctcc tcccagcccg ggcacacgcc ccatccagcc      180

gcatcccggg acccggtcgc caggacctcg ccgctgcaga ccccggctgc ccccggcgcc      240

gccgcggggc ctgcgctcag cccggtgcca cctgtggtcc acctgaccct ccgccaggcc      300

ggcgacgact tctcccgccg ctaccgccgc gacttcgccg agatgtccag ccagctgcac      360

ctgacgccct tcaccgcgcg gggacgcttt gccacggtgg tggaggagct cttcagggac      420

ggggtgaact gggggaggat tgtggccttc tttgagttcg gtggggtcat gtgtgtggag      480

agcgtcaacc gggagatgtc gcccctggtg gacaacatcg ccctgtggat gactgagtac      540

ctgaaccggc acctgcacac ctggatccag gataacggag gctgggatgc ctttgtggaa      600

ctgtacggcc ccagcatgcg gcctctgttt gatttctcct ggctgtctct gaagactctg      660

ctcagtttgg ccctggtggg agcttgcatc accctgggtg cctatctggg ccacaagtga      720


<210>  218
<211>  363
<212>  DNA
<213>  Homo sapiens;

<400>  218
atggagtcca aagaggaact agcggcaaac aatctcaacg gggaaaatgc ccaacaagaa       60

aacgaaggag gggagcaggc ccccacgcag aatgaagaag aatcccgcca tttgggaggg      120

ggtgaaggcc agaagcctgg aggaaatatc aggcgggggc gagttaggcg acttgtccct      180

aattttcgat gggccatacc taataggcat attgagcaca atgaagcgag agatgatgta      240

gaaaggtttg tagggcagat gatggaaatc aagagaaaga ctagggaaca gcagatgagg      300

cactatatgc gcttccaaac tcctgaacct gacaaccatt atgacttttg cctcatacct      360

tga                                                                    363


<210>  219
<211>  1989
<212>  DNA
<213>  Homo sapiens;

<400>  219
atgaagaagt tctctcggat gcccaagtcg gagggcggca gcggcggcgg agcggcgggt       60

ggcggggctg gcggggccgg ggccggggcc ggctgcggct ccggcggctc gtccgtgggg      120

gtccgggtgt tcgcggtcgg ccgccaccag gtcaccctgg aagagtcgct ggccgaaggt      180

ggattctcca cagttttcct cgtgcgtact cacggtggaa tccgatgtgc attgaagcga      240

atgtatgtca ataacatgcc agacctcaat gtttgtaaaa gggaaattac aattatgaaa      300

gagctatctg gtcacaaaaa tattgtgggc tatttggact gtgctgttaa ttcaattagt      360

gataatgtat gggaagtcct tatcttaatg gaatattgtc gagctggaca ggtagtgaat      420

caaatgaata agaagctaca gacgggtttt acagaaccag aagtgttaca gatattctgt      480

gatacctgtg aagctgttgc aaggttgcat cagtgtaaga ctccaataat tcaccgggat      540

ctgaaggtag aaaatatttt gttgaatgat ggtgggaact atgtactttg tgactttggc      600

agtgccacta ataaatttct taatcctcaa aaagatggag ttaatgtagt agaagaagaa      660

attaaaaagt atacaactct gtcatacaga gcccctgaaa tgatcaacct ttatggaggg      720

aaacccatca ccaccaaggc tgatatctgg gcactgggat gtctactcta taaactttgt      780

ttcttcactc ttccttttgg tgagagtcag gttgctatct gtgatggcaa cttcaccatc      840

ccagacaatt ctcgttactc ccgtaacata cattgcttaa taaggttcat gcttgaacca      900

gatccggaac atagacctga tatatttcaa gtgtcatatt ttgcatttaa atttgccaaa      960

aaggattgtc cagtctccaa catcaataat tcttctattc cttcagctct tcctgaaccg     1020

atgactgcta gtgaagcagc tgctaggaaa agccaaataa aagccagaat aacagatacc     1080

attggaccaa cagaaacctc aattgcacca agacaaagac caaaggccaa ctctgctact     1140

actgccactc ccagtgtgct gaccattcaa agttcagcaa cacctgttaa agtccttgct     1200

cctggtgaat tcggtaacca tagaccaaaa ggggcactaa gacctggaaa tggccctgaa     1260

attttattgg gtcagggacc tcctcagcag ccgccacagc agcatagagt actccagcaa     1320

ctacagcagg gagattggag attacagcaa ctccatttac agcatcgtca tcctcaccag     1380

cagcagcagc agcagcagca gcaacagcaa cagcagcagc agcaacagca acagcagcag     1440

cagcagcagc agcagcagca ccaccaccac caccaccacc acctacttca agatgcttat     1500

atgcagcagt atcaacatgc aacacagcag caacagatgc ttcaacaaca atttttaatg     1560

cattcggtat atcaaccaca accttctgca tcacagtatc ctacaatgat gccgcagtat     1620

cagcaggctt tctttcaaca gcagatgcta gctcaacatc agccgtctca acaacaggca     1680

tcacctgaat atcttacctc ccctcaagag ttctcaccag ccttagtttc ctacacttca     1740

tcacttccag ctcaggttgg aaccataatg gactcctcct atagtgccaa taggtcagtt     1800

gctgataaag aggccattgc aaatttcaca aatcagaaga acatcagcaa tccacctgat     1860

atgtcagggt ggaatccttt tggagaggat aatttctcta agttaacaga agaggaacta     1920

ttggacagag aatttgacct tctaagatca agtaagggac acttgaaggc ttattttgct     1980

tcacagtaa                                                             1989


<210>  220
<211>  3177
<212>  DNA
<213>  Homo sapiens;

<400>  220
atgaggagga aaggacgatg tcatcgaggc tctgcagcga ggcatccttc ttccccatgc       60

agtgttaaac actcccctac gcgagaaacg ctgacctacg ctcaagctca aaggatggta      120

gagatagaaa ttgaagggcg cttgcacagg atcagtattt ttgatcccct ggagatcata      180

ttggaagatg acctcactgc tcaagagatg agtgagtgca acagcaacaa ggaaaacagc      240

gagcggcctc ctgtctgctt aagaactaag cgtcacaaaa acaacagagt caaaaagaaa      300

aacgaggccc tccccagcgc ccacggcacg ccggcctcgg ccagtgccct cccggagccc      360

aaggtgcgca tcgtggagta cagccctccg tccgccccca ggaggcctcc tgtgtactac      420

aagttcatcg agaagtcggc cgaggaactg gacaacgagg tggagtatga catggacgag      480

gaggactatg cctggctgga gatcgtcaat gagaagcgca agggcgactg cgtccccgcc      540

gtgtcgcaga gcatgtttga gttcctgatg gaccgcttcg agaaggagtc gcactgcgag      600

aaccagaagc agggcgagca gcagtctctg atcgacgagg acgccgtgtg ctgcatctgc      660

atggacgggg agtgtcagaa cagcaacgtg atcctcttct gcgacatgtg caacctggcc      720

gtgcaccagg agtgctacgg ggtgccctac atccccgagg gccagtggct ctgccgccac      780

tgcctgcagt cgcgggcccg gcccgccgac tgtgtgctgt gccccaacaa gggtggtgcc      840

ttcaaaaaga cagatgacga ccgctggggt cacgtggtgt gtgccctgtg gatcccagag      900

gtcggctttg ccaacacggt gttcatcgag cccatcgatg gggtgaggaa catccctcca      960

gcccggtgga aactgacatg ctacctctgt aagcagaagg gcgtgggtgc ctgcatccag     1020

tgccacaaag caaactgcta cacagcattc catgtgacgt gtgcccagaa ggctggcctg     1080

tacatgaaaa tggagcccgt gaaggaactg actggcggtg gcaccacctt ctccgtcaga     1140

aagaccgctt actgtgatgt ccacacgcct ccaggctgca cccggaggcc tctgaatatt     1200

tacggggatg tcgaaatgaa aaatggcgtc tgtcgaaaag agagctcggt taaaacggtc     1260

aggtccacat ccaaggtcag gaagaaggca aaaaaggcta agaaagctct ggctgagccc     1320

tgcgcggtcc tgccgaccgt gtgcgctcct tatattcccc cgcagaggtt aaataggatt     1380

gcgaatcagg tggccattca gcggaagaag cagtttgtgg agcgagccca cagctactgg     1440

ctgctcaagc ggctgtccag gaacggggcc cccctgctgc ggcggctgca gtccagcctg     1500

cagtctcagc gaagctcaca gcagagagaa aatgatgagg agatgaaggc tgccaaagag     1560

aagctgaagt actggcagcg gctgcggcac gacctggagc gcgctcgcct gctgatcgag     1620

ctgctgcgca agcgggagaa gctcaagcgt gagcaggtga aggtggagca ggtcgccatg     1680

gagctgcggc tgaccccgct gacggtgctg ctgcgctcag tgctggacca gctgcaagac     1740

aaggaccccg ccaggatatt tgcgcagccc gtgagtctga aggaggtacc agattatttg     1800

gatcacatta aacatcccat ggactttgcc acaatgagga aacggttaga agctcaaggg     1860

tataaaaacc tccatgagtt tgaggaggat tttgatctca ttatagataa ctgcatgaag     1920

tacaatgcca gggacaccgt gttctataga gccgcggtga ggctgcgcga tcagggaggt     1980

gttgttctga ggcaggcccg gcgcgaggtg gacagcatcg gcttggaaga ggcctcgggg     2040

atgcacctgc ctgagcggcc tgctgcggca ccgcggcggc ctttctcctg ggaagacgtg     2100

gacaggttgc tggaccccgc caacagagcc cacctgggcc tggaggagca gctgagagag     2160

ctgctggaca tgctcgacct cacctgcgct atgaagtcca gcggctcccg gagcaagcgg     2220

gcaaagctgc tcaaaaagga aattgccctt ctccgaaaca agctgagcca gcagcacagc     2280

cagcccctgc ccacggggcc aggcttggaa ggcttcgaag aggacggagc tgcgctgggg     2340

ccggaggcgg gcgaggaagt ccttccgagg ttggagactc ttctgcagcc aaggaaaagg     2400

tcgcggagca catgcggaga ctccgaggtg gaggaggagt ccccaggaaa gcgcctggac     2460

gcaggtctca ccaacggctt tgggggtgcg aggagcgagc aggagccggg cggcggcctg     2520

gggaggaagg ccacaccccg acgacgctgt gcctccgagt ccagcatctc ctccagcaac     2580

agcccgctct gcgactcgag ctttaatgcg cccaaatgtg ggcggggcaa accggctctt     2640

gtgcgacggc acacgctgga ggaccgcagt gagctgatct cctgcatcga gaatgggaac     2700

tacgccaagg cggccaggat cgcagccgaa gtcggccaga gcagcatgtg gatctccact     2760

gatgccgccg cctcggtgct ggagcctctg aaggtggtgt gggccaagtg cagcggctac     2820

ccctcctacc cggcactgat catcgacccc aagatgcccc gtgtgcctgg ccaccacaac     2880

ggcgtcacca tcccggcccc acccctggac gtgctgaaga ttggggagca catgcagacc     2940

aagtctgatg agaagctgtt cctcgttctc ttttttgata ataagagaag ttggcagtgg     3000

cttcctaagt ccaaaatggt tccccttggt attgacgaaa ctatagacaa gttaaagatg     3060

atggaaggga ggaattccag catccggaag gccgtgcgga tcgcttttga ccgcgccatg     3120

aaccacctga gccgcgtcca cggggagccg accagcgacc tcagtgacat tgactga        3177


<210>  221
<211>  2169
<212>  DNA
<213>  Homo sapiens;

<400>  221
atgtctgcgg agagcggccc tgggacgaga ttgagaaatc tgccagtaat gggggatgga       60

ctagaaactt cccaaatgtc tacaacacag gcccaggccc aaccccagcc agccaacgca      120

gccagcacca accccccgcc cccagagacc tccaacccta acaagcccaa gaggcagacc      180

aaccaactgc aatacctgct cagagtggtg ctcaagacac tatggaaaca ccagtttgca      240

tggcctttcc agcagcctgt ggatgccgtc aagctgaacc tccctgatta ctataagatc      300

attaaaacgc ctatggatat gggaacaata aagaagcgct tggaaaacaa ctattactgg      360

aatgctcagg aatgtatcca ggacttcaac actatgttta caaattgtta catctacaac      420

aagcctggag atgacatagt cttaatggca gaagctctgg aaaagctctt cttgcaaaaa      480

ataaatgagc tacccacaga agaaaccgag atcatgatag tccaggcaaa aggaagagga      540

cgtgggagga aagaaacagg gacagcaaaa cctggcgttt ccacggtacc aaacacaact      600

caagcatcga ctcctccgca gacccagacc cctcagccga atcctcctcc tgtgcaggcc      660

acgcctcacc ccttccctgc cgtcaccccg gacctcatcg tccagacccc tgtcatgaca      720

gtggtgcctc cccagccact gcagacgccc ccgccagtgc ccccccagcc acaaccccca      780

cccgctccag ctccccagcc cgtacagagc cacccaccca tcatcgcggc caccccacag      840

cctgtgaaga caaagaaggg agtgaagagg aaagcagaca ccaccacccc caccaccatt      900

gaccccattc acgagccacc ctcgctgccc ccggagccca agaccaccaa gctgggccag      960

cggcgggaga gcagccggcc tgtgaaacct ccaaagaagg acgtgcccga ctctcagcag     1020

cacccagcac cagagaagag cagcaaggtc tcggagcagc tcaagtgctg cagcggcatc     1080

ctcaaggaga tgtttgccaa gaagcacgcc gcctacgcct ggcccttcta caagcctgtg     1140

gacgtggagg cactgggcct acacgactac tgtgacatca tcaagcaccc catggacatg     1200

agcacaatca agtctaaact ggaggcccgt gagtaccgtg atgctcagga gtttggtgct     1260

gacgtccgat tgatgttctc caactgctat aagtacaacc ctcctgacca tgaggtggtg     1320

gccatggccc gcaagctcca ggatgtgttc gaaatgcgct ttgccaagat gccggacgag     1380

cctgaggagc cagtggtggc cgtgtcctcc ccggcagtgc cccctcccac caaggttgtg     1440

gccccgccct catccagcga cagcagcagc gatagctcct cggacagtga cagttcgact     1500

gatgactctg aggaggagcg agcccagcgg ctggctgagc tccaggagca gctcaaagcc     1560

gtgcacgagc agcttgcagc cctctctcag ccccagcaga acaaaccaaa gaaaaaggag     1620

aaagacaaga aggaaaagaa aaaagaaaag cacaaaagga aagaggaagt ggaagagaat     1680

aaaaaaagca aagccaagga acctcctcct aaaaagacga agaaaaataa tagcagcaac     1740

agcaatgtga gcaagaagga gccagcgccc atgaagagca agccccctcc cacgtatgag     1800

tcggaggaag aggacaagtg caagcctatg tcctatgagg agaagcggca gctcagcttg     1860

gacatcaaca agctccccgg cgagaagctg ggccgcgtgg tgcacatcat ccagtcacgg     1920

gagccctccc tgaagaattc caaccccgac gagattgaaa tcgactttga gaccctgaag     1980

ccgtccacac tgcgtgagct ggagcgctat gtcacctcct gtttgcggaa gaaaaggaaa     2040

cctcaagctg agaaagttga tgtgattgcc ggctcctcca agatgaaggg cttctcgtcc     2100

tcagagtcgg agagctccag tgagtccagc tcctctgaca gcgaagactc cgaaacaggt     2160

cctgcctaa                                                             2169


<210>  222
<211>  516
<212>  DNA
<213>  Homo sapiens;

<400>  222
atgcatccct tctacacccg ggccgccacc atgataggcg agatcgccgc cgccgtgtcc       60

ttcatctcca agtttctccg caccaagggg ctcacgagcg agcgacagct gcagaccttc      120

agccagagcc tgcaggagct gctggcagaa cattataaac atcactggtt cccagaaaag      180

ccatgcaagg gatcgggtta ccgttgtatt cgcatcaacc ataaaatgga tcctctgatt      240

ggacaggcag cacagcggat tggactgagc agtcaggagc tgttcaggct tctcccaagt      300

gaactcacac tctgggttga cccctatgaa gtgtcctaca gaattggaga ggatggctcc      360

atctgtgtgc tgtatgaagc ctcaccagca ggaggtagca ctcaaaacag caccaacgtg      420

caaatggtag acagccgaat cagctgtaag gaggaacttc tcttgggcag aacgagccct      480

tccaaaaact acaatatgat gactgtatca ggttaa                                516


<210>  223
<211>  876
<212>  DNA
<213>  Homo sapiens;

<400>  223
atgtctcagg aaggtgtgga gctggagaag agcgtccggc gcctccggga gaagtttcat       60

gggaaggtat cctccaagaa ggcgggggct ctgatgagga aattcggcag cgaccacacg      120

ggagtggggc gctccatcgt gtacggggta aagcaaaaag atggccaaga actaagtaac      180

gatctggatg cccaggatcc accagaagat atgaagcagg accgggacat tcaggcagtg      240

gcgacctccc tcctgccact gacagaagcc aacctacgca tgtttcaacg tgcccaggac      300

gaccttatcc ctgctgtgga ccggcagttt gcctgctcct cctgcgacca cgtctggtgg      360

cgccgcgtgc cccagcggaa ggaggtatcc cggtgccgga aatgccggaa gcgctacgag      420

ccagtgccag ctgacaagat gtggggcctg gctgagttcc actgcccgaa gtgtcggcac      480

aacttccggg gctgggcaca gatggggtcc ccgtccccct gctacgggtg cggcttcccc      540

gtgtatccaa cacggatcct ccccccgcgc tgggaccggg acccggatcg ccgcagcacc      600

cacactcact cctgctcagc tgccgactgc tacaaccggc gagagcccca cgtgcctggg      660

acatcctgtg ctcaccccaa gagccggaag cagaaccacc tgcccaaagt gctccacccc      720

agcaaccctc acattagcag tggctccact gtggccacct gcttgagcca gggtggcctc      780

ctggaagacc tggacaacct catcctggag gacctgaagg aggaggagga ggaagaggag      840

gaggtggagg acgaggaggg cgggcccagg gagtga                                876


<210>  224
<211>  501
<212>  DNA
<213>  Homo sapiens;

<400>  224
atggaggcgg ggccgcatcc ccggccgggg cactgctgca agcctggggg gcggctggac       60

atgaaccacg gcttcgtgca ccatatccga cggaaccaga tcgctcggga cgactatgac      120

aagaaggtga agcaggcggc caaggagaag gtgaggaggc ggcacacgcc cgcgccgacg      180

cggccccgca agccagacct gcaggtgtac ctgccgcgac accgagatgt ctctgcccac      240

ccacgcaacc cagactatga agagtccggt gaaagcagca gtagtggagg ctctgagctg      300

gagccttctg gccatcagct cttctgctta gaatacgagg cagacagtgg agaggtcaca      360

tcagttatcg tctatcaggg tgatgaccca ggaaaggtga gtgagaaggt gtcggcacac      420

acgcctctgg atccacccat gcgagaagcc ctcaagttgc gtatccagga ggagattgca      480

aagcgccaga gccaacactg a                                                501


<210>  225
<211>  1074
<212>  DNA
<213>  Homo sapiens;

<400>  225
atggcccggg agaacggcga gagcagctcc tcctggaaaa agcaagctga agacatcaag       60

aagatcttcg agttcaaaga gaccctcgga accggggcct tttccgaagt ggttttagct      120

gaagagaagg caactggcaa gctctttgct gtgaagtgta tccctaagaa ggcgctgaag      180

ggcaaggaaa gcagcataga gaatgagata gccgtcctga gaaagattaa gcatgaaaat      240

attgttgccc tggaagacat ttatgaaagc ccaaatcacc tgtacttggt catgcagctg      300

gtgtccggtg gagagctgtt tgaccggata gtggagaagg ggttttatac agagaaggat      360

gccagcactc tgatccgcca agtcttggac gccgtgtact atctccacag aatgggcatc      420

gtccacagag acctcaagcc cgaaaatctc ttgtactaca gtcaagatga ggagtccaaa      480

ataatgatca gtgactttgg attgtcaaaa atggagggca aaggagatgt gatgtccact      540

gcctgtggaa ctccaggcta tgtcgctcct gaagtcctcg cccagaaacc ttacagcaaa      600

gccgttgact gctggtccat cggagtgatt gcctacatct tgctctgcgg ctaccctcct      660

ttttatgatg aaaatgactc caagctcttt gagcagatcc tcaaggcgga atatgagttt      720

gactctccct actgggatga catctccgac tctgcaaaag acttcattcg gaacctgatg      780

gagaaggacc cgaataaaag atacacgtgt gagcaggcag ctcggcaccc atggatcgct      840

ggtgacacag ccctcaacaa aaacatccac gagtccgtca gcgcccagat ccggaaaaac      900

tttgccaaga gcaaatggag acaagcattt aatgccacgg ccgtcgtcag acatatgaga      960

aaactacacc tcggcagcag cctggacagt tcaaatgcaa gtgtttcgag cagcctcagt     1020

ttggccagcc aaaaagactg tgcgtatgta gcaaaaccag aatccctcag ctga           1074


<210>  226
<211>  1488
<212>  DNA
<213>  Homo sapiens;

<400>  226
atggccacca ccgccacctg cacccgtttc accgacgact accagctctt cgaggagctt       60

ggcaagggtg ctttctctgt ggtccgcagg tgtgtgaaga aaacctccac gcaggagtac      120

gcagcaaaaa tcatcaatac caagaagttg tctgcccggg atcaccagaa actagaacgt      180

gaggctcgga tatgtcgact tctgaaacat ccaaacatcg tgcgcctcca tgacagtatt      240

tctgaagaag ggtttcacta cctcgtgttt gaccttgtta ccggcgggga gctgtttgaa      300

gacattgtgg ccagagagta ctacagtgaa gcagatgcca gccactgtat acatcagatt      360

ctggagagtg ttaaccacat ccaccagcat gacatcgtcc acagggacct gaagcctgag      420

aacctgctgc tggcgagtaa atgcaagggt gccgccgtca agctggctga ttttggccta      480

gccatcgaag tacagggaga gcagcaggct tggtttggtt ttgctggcac cccaggttac      540

ttgtcccctg aggtcttgag gaaagatccc tatggaaaac ctgtggatat ctgggcctgc      600

ggggtcatcc tgtatatcct cctggtgggc tatcctccct tctgggatga ggatcagcac      660

aagctgtatc agcagatcaa ggctggagcc tatgatttcc catcaccaga atgggacacg      720

gtaactcctg aagccaagaa cttgatcaac cagatgctga ccataaaccc agcaaagcgc      780

atcacggctg accaggctct caagcacccg tgggtctgtc aacgatccac ggtggcatcc      840

atgatgcatc gtcaggagac tgtggagtgt ttgcgcaagt tcaatgcccg gagaaaactg      900

aagggtgcca tcctcacgac catgcttgtc tccaggaact tctcagctgc caaaagccta      960

ttgaacaaga agtcggatgg cggtgtcaag gagccacaaa ccactgtggt acacaacgct     1020

acagatggga tcaagggctc cacagagagc tgcaacacca ccacagaaga tgaggacctc     1080

aaagtgcgaa aacaggagat cattaagatt acagaacagc tgattgaagc catcaacaat     1140

ggggactttg aggcctacac gaagatttgt gatccaggcc tcacttcctt tgagcctgag     1200

gcccttggta acctcgtgga ggggatggat ttccataagt tttactttga gaatctcctg     1260

tccaagaaca gcaagcctat ccataccacc atcctaaacc cacacgtcca cgtgattggg     1320

gaggacgcag cgtgcatcgc ctacatccgc ctcacccagt acatcgacgg gcagggtcgg     1380

cctcgcacca gccagtcaga agagacccgg gtctggcacc gtcgggatgg caagtggctc     1440

aatgtccact atcactgctc aggggcccct gccgcaccgc tgcagtga                  1488


<210>  227
<211>  1428
<212>  DNA
<213>  Homo sapiens;

<400>  227
atggctgaca tgcaaaatct ggtagaaaga ttggagaggg cagtgggccg cctggaggca       60

gtatctcata cctctgacat gcaccgtggg tatgcagaca gtccttcaaa agcaggagca      120

gctccatatg tgcaggcatt tgactcgctg cttgctggtc ctgtggcaga gtacttgaag      180

atcagtaaag agattggggg agacgtgcag aaacatgcgg agatggtcca cacaggtttg      240

aagttggagc gagctctgtt ggttacagct tctcagtgtc aacagccagc agaaaataag      300

ctttccgatt tgttggcacc catctcagag cagatcaaag aagtgataac ctttcgggag      360

aagaaccgag gcagcaagtt gtttaatcac ctgtcagctg tcagcgaaag tatccaggcc      420

ctgggctggg tggctatggc tcccaagcct ggcccttatg tgaaagaaat gaatgatgcc      480

gccatgtttt atacaaaccg agtcctcaaa gagtacaaag atgtggataa gaagcatgta      540

gactgggtca aagcttattt aagtatatgg acagagctgc aggcttacat taaggagttc      600

cataccaccg gactggcctg gagcaaaacg gggcctgtgg caaaagaact gagcggactg      660

ccatctggac cctctgccgg atcatgtcct cctccccctc caccatgccc ccctcctccc      720

ccagtctcta ccatttcatg ctcatatgag tctgcttccc gctcatcact gttcgcgcag      780

attaatcagg gggagagcat tacacatgcc ctgaaacatg tatctgatga catgaagact      840

cacaagaacc ctgccctgaa ggctcagagt ggtccagtac gcagtggccc caaaccattc      900

tctgcaccta aaccccaaac cagcccatcc cccaaacgag ccacaaagaa ggagccagct      960

gtacttgaac tggagggcaa gaagtggaga gtggaaaatc aggaaaatgt ttccaacctg     1020

gtgattgagg acacagagct gaaacaggtg gcttacatat acaagtgtgt caacacgaca     1080

ttgcaaatca agggcaaaat taactccatt acagtagata actgtaagaa acttggcctg     1140

gtattcgatg acgtggtggg cattgtggag ataatcaaca gtaaggatgt caaagttcag     1200

gtaatgggta aagtgccaac catatccatc aacaaaacag atggctgcca tgcttacctg     1260

agcaagaatt ccctggattg tgaaatagtc agtgccaaat cttccgagat gaatgtcctc     1320

attcctacag aaggcggtga ctttaatgaa ttcccagttc ctgagcagtt caagacccta     1380

tggaacgggc agaagttggt caccacagtg acagaaattg ctggataa                  1428


<210>  228
<211>  2112
<212>  DNA
<213>  Homo sapiens;

<400>  228
atggcggacc ggcggcggca gcgcgcttcg caagacaccg aggacgagga atctggtgct       60

tcgggctccg acagcggcgg ctccccgttg cggggaggcg ggagctgcag cggtagcgcc      120

ggaggcggcg gcagcggctc tctgccttca cagcgcggag gccgaaccgg ggcccttcat      180

ctgcggcggg tggagagcgg gggcgccaag agtgctgagg agtcggagtg tgagagtgaa      240

gatggcattg aaggtgatgc tgttctctcg gattatgaaa gtgcagaaga ctcggaaggt      300

gaagaaggtg aatacagtga agaggaaaac tccaaagtgg agctgaaatc agaagctaat      360

gatgctgtta attcttcaac aaaagaagag aagggagaag aaaagcctga caccaaaagc      420

actgtgactg gagagaggca aagtggggac ggacaggaga gcacagagcc tgtggagaac      480

aaagtgggta aaaagggccc taagcatttg gatgatgatg aagatcggaa gaatccagca      540

tacatacctc ggaaagggct cttctttgag catgatcttc gagggcaaac tcaggaggag      600

gaagtcagac ccaaggggcg tcagcgaaag ctatggaagg atgagggtcg ctgggagcat      660

gacaagttcc gggaagatga gcaggcccca aagtcccgac aggagctcat tgctctttat      720

ggttatgaca ttcgctcagc tcataatcct gatgacatca aacctcgaag aatccggaaa      780

ccccgatatg ggagtcctcc acaaagagat ccaaactgga acggtgagcg gctaaacaag      840

tctcatcgcc accagggtct tgggggcacc ctaccaccaa ggacatttat taacaggaat      900

gctgcaggta ccggccgtat gtctgcaccc aggaattatt ctcgatctgg gggcttcaag      960

gaaggtcgtg ctggttttag gcctgtggaa gctggtgggc agcatggtgg ccggtctggt     1020

gagactgtta agcatgagat tagttaccgg tcacggcgcc tagagcagac ttctgtgagg     1080

gatccatctc cagaagcaga tgctccagtg cttggcagtc ctgagaagga agaggcagcc     1140

tcagagccac cagctgctgc tcctgatgct gcaccaccac cccctgatag gcccattgag     1200

aagaaatcct attcccgggc aagaagaact cgaaccaaag ttggagatgc agtcaagctt     1260

gcagaggagg tgccccctcc tcctgaagga ctgattccag cacctccagt cccagaaacc     1320

accccaactc cacctactaa gactgggacc tgggaagctc cggtggattc tagtacaagt     1380

ggacttgagc aagatgtggc acaactaaat atagcagaac agaattggag tccggggcag     1440

ccttctttcc tgcaaccacg ggaacttcga ggtatgccca accatataca catgggagca     1500

ggacctccac ctcagtttaa ccggatggaa gaaatgggtg tccagggtgg tcgagccaaa     1560

cgctattcat cccagcggca aagacctgtg ccagagcccc ccgcccctcc agtgcatatc     1620

agtatcatgg agggacatta ctatgatcca ctgcagttcc agggaccaat ctatacccat     1680

ggtgacagcc ctgccccgct gcctccacag ggcatgcttg tgcagccagg aatgaacctt     1740

ccccacccag gtttacatcc ccaccagaca ccagctcctc tgcccaatcc aggcctctat     1800

cccccaccag tgtccatgtc tccaggacag ccaccacctc agcagttgct tgctcctact     1860

tacttttctg ctccaggcgt catgaacttt ggtaatccca gttaccctta tgctccaggg     1920

gcactgcctc ccccaccacc gcctcatctg tatcctaata cacaggcccc atcacaggta     1980

tatggaggag tgacctacta taaccccgcc cagcagcagg tgcagccaaa gccctcccca     2040

ccccggagga ctccccagcc agtcaccatc aagccccctc cacctgaggt tgtaagcagg     2100

ggttccagtt aa                                                         2112


<210>  229
<211>  1491
<212>  DNA
<213>  Homo sapiens;

<400>  229
atggacttca gcagaaatct ttatgatatt ggggaacaac tggacagtga agatctggcc       60

tccctcaagt tcctgagcct ggactacatt ccgcaaagga agcaagaacc catcaaggat      120

gccttgatgt tattccagag actccaggaa aagagaatgt tggaggaaag caatctgtcc      180

ttcctgaagg agctgctctt ccgaattaat agactggatt tgctgattac ctacctaaac      240

actagaaagg aggagatgga aagggaactt cagacaccag gcagggctca aatttctgcc      300

tacaggttcc acttctgccg catgagctgg gctgaagcaa acagccagtg ccagacacag      360

tctgtacctt tctggcggag ggtcgatcat ctattaataa gggtcatgct ctatcagatt      420

tcagaagaag tgagcagatc agaattgagg tcttttaagt ttcttttgca agaggaaatc      480

tccaaatgca aactggatga tgacatgaac ctgctggata ttttcataga gatggagaag      540

agggtcatcc tgggagaagg aaagttggac atcctgaaaa gagtctgtgc ccaaatcaac      600

aagagcctgc tgaagataat caacgactat gaagaattca gcaaagggga ggagttgtgt      660

ggggtaatga caatctcgga ctctccaaga gaacaggata gtgaatcaca gactttggac      720

aaagtttacc aaatgaaaag caaacctcgg ggatactgtc tgatcatcaa caatcacaat      780

tttgcaaaag cacgggagaa agtgcccaaa cttcacagca ttagggacag gaatggaaca      840

cacttggatg caggggcttt gaccacgacc tttgaagagc ttcattttga gatcaagccc      900

cacgatgact gcacagtaga gcaaatctat gagattttga aaatctacca actcatggac      960

cacagtaaca tggactgctt catctgctgt atcctctccc atggagacaa gggcatcatc     1020

tatggcactg atggacagga ggcccccatc tatgagctga catctcagtt cactggtttg     1080

aagtgccctt cccttgctgg aaaacccaaa gtgtttttta ttcaggcttg tcagggggat     1140

aactaccaga aaggtatacc tgttgagact gattcagagg agcaacccta tttagaaatg     1200

gatttatcat cacctcaaac gagatatatc ccggatgagg ctgactttct gctggggatg     1260

gccactgtga ataactgtgt ttcctaccga aaccctgcag agggaacctg gtacatccag     1320

tcactttgcc agagcctgag agagcgatgt cctcgaggcg atgatattct caccatcctg     1380

actgaagtga actatgaagt aagcaacaag gatgacaaga aaaacatggg gaaacagatg     1440

cctcagccta ctttcacact aagaaaaaaa cttgtcttcc cttctgattg a              1491


<210>  230
<211>  756
<212>  DNA
<213>  Homo sapiens;

<400>  230
atggagctgt cagccatcgg cgagcaggtg ttcgccgtgg agagcatccg gaagaagcgc       60

gtgcggaagg gtaaagtcga gtatctggtg aagtggaaag gatggccccc aaagtacagc      120

acgtgggagc cagaagagca catcttggac ccccgcctcg tcatggccta cgaggagaag      180

gaggagagag accgagcatc ggggtatagg aagagaggtc cgaaacccaa gcggcttctg      240

ctgcagcggc tgtacagcat ggacctgcgg agctcccaca aggccaaggg caaggagaag      300

ctctgcttct ccctgacgtg cccactcggc agcgggagcc ctgagggggt ggtcaaggcg      360

ggggcacctg agctggtgga caagggcccc ttggtgccca ccctgccctt cccgctccgc      420

aagccccgaa aggcccacaa gtacctgcgg ctctcgcgca agaagttccc gccccgcggg      480

cccaacctgg agagccacag ccatcgacgg gagctcttcc tgcaggagcc accggcccca      540

gacgtcctgc aggcggctgg cgagtgggag cctgctgcgc agccccctga agaggaggca      600

gatgccgacc tggccgaggg gccccctccc tggacacctg cgctcccctc aagtgaggtg      660

accgtgaccg acatcaccgc caactccatc accgtcacct tccgcgaggc ccaggcagct      720

gagggcttct tccgagaccg cagtgggaag ttctga                                756


<210>  231
<211>  879
<212>  DNA
<213>  Homo sapiens;

<400>  231
atggagctgc tgtgttgcga aggcacccgg cacgcgcccc gggccgggcc ggacccgcgg       60

ctgctggggg accagcgtgt cctgcagagc ctgctccgcc tggaggagcg ctacgtaccc      120

cgcgcctcct acttccagtg cgtgcagcgg gagatcaagc cgcacatgcg gaagatgctg      180

gcttactgga tgctggaggt atgtgaggag cagcgctgtg aggaggaagt cttccccctg      240

gccatgaact acctggatcg ctacctgtct tgcgtcccca cccgaaaggc gcagttgcag      300

ctcctgggtg cggtctgcat gctgctggcc tccaagctgc gcgagaccac gcccctgacc      360

atcgaaaaac tgtgcatcta caccgaccac gctgtctctc cccgccagtt gcgggactgg      420

gaggtgctgg tcctagggaa gctcaagtgg gacctggctg ctgtgattgc acatgatttc      480

ctggccttca ttctgcaccg gctctctctg ccccgtgacc gacaggcctt ggtcaaaaag      540

catgcccaga cctttttggc cctctgtgct acagattata cctttgccat gtacccgcca      600

tccatgatcg ccacgggcag cattggggct gcagtgcaag gcctgggtgc ctgctccatg      660

tccggggatg agctcacaga gctgctggca gggatcactg gcactgaagt ggactgcctg      720

cgggcctgtc aggagcagat cgaagctgca ctcagggaga gcctcaggga agcctctcag      780

accagctcca gcccagcgcc caaagccccc cggggctcca gcagccaagg gcccagccag      840

accagcactc ctacagatgt cacagccata cacctgtag                             879


<210>  232
<211>  1035
<212>  DNA
<213>  Homo sapiens;

<400>  232
atgaaggatt tgggggcaga gcacttggca ggtcatgaag gggtccaact tctcgggttg       60

ttgaacgtct acctggaaca agaagagaga ttccaacctc gagaaaaagg gctgagtttg      120

attgaggcta ccccggagaa tgataacact ttgtgtccag gattgagaaa tgccaaagtt      180

gaagatttaa ggagtttagc caactttttt ggatcttgca ctgaaacttt tgtcctggct      240

gtcaatattt tggacaggtt cttggctctt atgaaggtga aacctaaaca tttgtcttgc      300

attggagtct gttctttttt gctggctgct agaatagttg aagaagactg caatattcca      360

tccactcatg atgtgatccg gattagtcag tgtaaatgta ctgcttctga cataaaacgg      420

atggaaaaaa taatttcaga aaaattgcac tatgaattgg aagctactac tgccttaaac      480

tttttgcact tataccatac tattatactt tgtcatactt cagaaaggaa agaaatactg      540

agccttgata aactagaagc tcagctgaaa gcttgcaact gccgactcat cttttcaaaa      600

gcaaaaccat ctgtattagc cttgtgcctt ctcaatttgg aagtggaaac tttgaaatct      660

gttgaattac tggaaattct cttgctagtt aaaaaacatt ccaagattaa tgacactgag      720

ttcttctact ggagagagtt ggtttctaaa tgcctagccg agtattcttc tcctgaatgt      780

tgcaaaccag atcttaagaa gttggtttgg atcgtttcaa ggcgcacagc ccagaacctc      840

cacaacagct actatagtgt tcctgagctg ccaacgatac ctgagggggg ttgttttgat      900

gaaagtgaaa gtgaggactc ttgtgaagat atgagttgtg gagaggagag tctcagcagc      960

tctcctccca gtgatcaaga gtgcaccttc tttttcaact tcaaagtggc acaaacactg     1020

tgctttccat cttag                                                      1035


<210>  233
<211>  1992
<212>  DNA
<213>  Homo sapiens;

<400>  233
atggcgtcgg gccgtggagc ttcttctcgc tggttcttta ctcgggaaca gctggagaac       60

acgccgagcc gccgctgcgg agtggaggcg gataaagagc tctcgtgccg ccagcaggcg      120

gccaacctca tccaggagat gggacagcgt ctcaatgtct ctcagcttac aataaacact      180

gcgattgttt atatgcacag gttttatatg caccattctt tcaccaaatt caacaaaaat      240

ataatatcgt ctactgcatt atttttggct gcaaaagtgg aagaacaggc tcgaaaactt      300

gaacatgtta tcaaagtagc acatgcttgt cttcatcctc tagagccact gctggatact      360

aaatgtgatg cttaccttca acagactcaa gaactggtta tacttgaaac cataatgcta      420

caaactctag gttttgagat caccattgaa cacccacaca cagatgtggt gaaatgtacc      480

cagttagtaa gagcaagcaa ggatttggca cagacatcct atttcatggc taccaacagt      540

ctgcatctta caaccttctg tcttcagtac aaaccaacag tgatagcatg tgtatgcatt      600

catttggctt gcaaatggtc caattgggag atccctgtat caactgatgg aaagcattgg      660

tgggaatatg tggatcctac agttactcta gaattattag atgagctaac acatgagttt      720

ctacaaatat tggagaaaac gcctaatagg ttgaagaaga ttcgaaactg gagggctaat      780

caggcagcta ggaaaccaaa agtagatgga caggtatcag agacaccact tcttggttca      840

tctttggtcc agaattccat tttagtagat agtgtcactg gtgtgcctac aaacccaagt      900

tttcagaaac catctacatc agcattccct gcgccagtac ctctaaattc aggaaatatt      960

tctgttcaag acagccatac atctgataat ttgtcaatgc tagcaacagg aatgccaagt     1020

acttcatacg gtttatcatc acaccaggaa tggcctcaac atcaagactc agcaaggaca     1080

gaacagctat attcacagaa acaggagaca tctttgtctg gtagccagta caacatcaac     1140

ttccagcagg gaccttctat atcactgcat tcaggattac atcacagacc tgacaaaatt     1200

tcagatcatt cttctgttaa gcaagaatat actcataaag cagggagcag taaacaccat     1260

gggccaattt ccactactcc aggaataatt cctcagaaaa tgtctttaga taaatataga     1320

gaaaagcgta aactagaaac tcttgatctc gatgtaaggg atcattatat agctgcccag     1380

gtagaacagc agcacaaaca agggcagtca caggcagcca gcagcagttc tgttacttct     1440

cccattaaaa tgaaaatacc tatcgcaaat actgaaaaat acatggcaga caaaaaggaa     1500

aagagtgggt cactgaaatt acggattcca ataccaccca ctgataaaag cgccagtaaa     1560

gaagaactga aaatgaaaat aaaagtttct tcttcagaaa gacacagctc ttctgatgaa     1620

ggcagtggga agagcaaaca ttcaagccca catattagca gagaccataa ggagaagcac     1680

aaggagcatc cttcaagccg ccaccacacc agcagccaca agcattccca ctcgcatagt     1740

ggcagcagca gcggtggcag taaacacagt gccgacggaa taccacccac tgttctgagg     1800

agtcctgttg gcctgagcag tgatggcatt tcctctagct ccagctcttc aaggaagagg     1860

ctgcatgtca atgatgcatc tcacaaccac cactccaaaa tgagcaaaag ttccaaaagt     1920

tcaggtgggc tacggacatc tcagcaccct cgtgaaactg gacaagaagc cagtggagac     1980

caacggtcct ga                                                         1992


<210>  234
<211>  1137
<212>  DNA
<213>  Homo sapiens;

<400>  234
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  235
<211>  846
<212>  DNA
<213>  Homo sapiens;

<400>  235
atgtcagccc aggagagctg cctcagcctc atcaagtact tcctcttcgt tttcaacctc       60

ttcttcttcg tcctcggcag cctgatcttc tgcttcggca tctggatcct cattgacaag      120

accagcttcg tgtcctttgt gggcttggcc ttcgtgcctc tgcagatctg gtccaaagtc      180

ctggccatct caggaatctt caccatgggc atcgccctcc tgggttgtgt gggggccctc      240

aaggagctcc gctgcctcct gggcctgtat tttgggatgc tgctgctcct gtttgccaca      300

cagatcaccc tgggaatcct catctccact cagcgggccc agctggagcg aagcttgcgg      360

gacgtcgtag agaaaaccat ccaaaagtac ggcaccaacc ccgaggagac cgcggccgag      420

gagagctggg actatgtgca gttccagctg cgctgctgcg gctggcacta cccgcaggac      480

tggttccaag tcctcatcct gagaggtaac gggtcggagg cgcaccgcgt gccctgctcc      540

tgctacaact tgtcggcgac caacgactcc acaatcctag ataaggtgat cttgccccag      600

ctcagcaggc ttggacacct ggcgcggtcc agacacagtg cagacatctg cgctgtccct      660

gcagagagcc acatctaccg cgagggctgc gcgcagggcc tccagaagtg gctgcacaac      720

aaccttattt ccatagtggg catttgcctg ggcgtcggcc tactcgagct cgggttcatg      780

acgctctcga tattcctgtg cagaaacctg gaccacgtct acaaccggct cgctcgatac      840

cgttag                                                                 846


<210>  236
<211>  1959
<212>  DNA
<213>  Homo sapiens;

<400>  236
atggccacct ccatgggcct gctgctgctg ctgctgctgc tcctgaccca gcccggggcg       60

gggacgggag ctgacacgga ggcggtggtc tgcgtgggga ccgcctgcta cacggcccac      120

tcgggcaagc tgagcgctgc cgaggcccag aaccactgca accagaacgg gggcaacctg      180

gccactgtga agagcaagga ggaggcccag cacgtccagc gagtactggc ccagctcctg      240

aggcgggagg cagccctgac ggcgaggatg agcaagttct ggattgggct ccagcgagag      300

aagggcaagt gcctggaccc tagtctgccg ctgaagggct tcagctgggt gggcgggggg      360

gaggacacgc cttactctaa ctggcacaag gagctccgga actcgtgcat ctccaagcgc      420

tgtgtgtctc tgctgctgga cctgtcccag ccgctccttc ccagccgcct ccccaagtgg      480

tctgagggcc cctgtgggag cccaggctcc cccggaagta acattgaggg cttcgtgtgc      540

aagttcagct tcaaaggcat gtgccggcct ctggccctgg ggggcccagg tcaggtgacc      600

tacaccaccc ccttccagac caccagttcc tccttggagg ctgtgccctt tgcctctgcg      660

gccaatgtag cctgtgggga aggtgacaag gacgagactc agagtcatta tttcctgtgc      720

aaggagaagg cccccgatgt gttcgactgg ggcagctcgg gccccctctg tgtcagcccc      780

aagtatggct gcaacttcaa caatgggggc tgccaccagg actgctttga agggggggat      840

ggctccttcc tctgcggctg ccgaccagga ttccggctgc tggatgacct ggtgacctgt      900

gcctctcgaa acccttgcag ctccagccca tgtcgtgggg gggccacgtg cgtcctggga      960

ccccatggga aaaactacac gtgccgctgc ccccaagggt accagctgga ctcgagtcag     1020

ctggactgtg tggacgtgga tgaatgccag gactccccct gtgcccagga gtgtgtcaac     1080

acccctgggg gcttccgctg cgaatgctgg gttggctatg agccgggcgg tcctggagag     1140

ggggcctgtc aggatgtgga tgagtgtgct ctgggtcgct cgccttgcgc ccagggctgc     1200

accaacacag atggctcatt tcactgctcc tgtgaggagg gctacgtcct ggccggggag     1260

gacgggactc agtgccagga cgtggatgag tgtgtgggcc cggggggccc cctctgcgac     1320

agcttgtgct tcaacacaca agggtccttc cactgtggct gcctgccagg ctgggtgctg     1380

gccccaaatg gggtctcttg caccatgggg cctgtgtctc tgggaccacc atctgggccc     1440

cccgatgagg aggacaaagg agagaaagaa gggagcaccg tgccccgtgc tgcaacagcc     1500

agtcccacaa ggggccccga gggcaccccc aaggctacac ccaccacaag tagaccttcg     1560

ctgtcatctg acgcccccat cacatctgcc ccactcaaga tgctggcccc cagtgggtcc     1620

ccaggcgtct ggagggagcc cagcatccat cacgccacag ctgcctctgg cccccaggag     1680

cctgcaggtg gggactcctc cgtggccaca caaaacaacg atggcactga cgggcaaaag     1740

ctgcttttat tctacatcct aggcaccgtg gtggccatcc tactcctgct ggccctggct     1800

ctggggctac tggtctatcg caagcggaga gcgaagaggg aggagaagaa ggagaagaag     1860

ccccagaatg cggcagacag ttactcctgg gttccagagc gagctgagag cagggccatg     1920

gagaaccagt acagtccgac acctgggaca gactgctga                            1959


<210>  237
<211>  2229
<212>  DNA
<213>  Homo sapiens;

<400>  237
atgggaggcc gcgtctttct cgcattctgt gtctggctga ctctgccggg agctgaaacc       60

caggactcca ggggctgtgc ccggtggtgc cctcagaact cctcgtgtgt caatgccacc      120

gcctgtcgct gcaatccagg gttcagctct ttttctgaga tcatcaccac cccgacggag      180

acttgtgacg acatcaacga gtgtgcaaca ccgtcgaaag tgtcatgcgg aaaattctcg      240

gactgctgga acacagaggg gagctacgac tgcgtgtgca gcccgggata tgagcctgtt      300

tctggggcaa aaacattcaa gaatgagagc gagaacacct gtcaagatgt ggacgagtgc      360

agctccgggc agcatcagtg tgacagctcc accgtctgct tcaacaccgt gggttcatac      420

agctgccgct gccgcccagg ctggaagccc agacacggaa tcccgaataa ccaaaaggac      480

actgtctgtg aagatatgac tttctccacc tggaccccgc cccctggagt ccacagccag      540

acgctttccc gattcttcga caaagtccag gacctgggca gagactccaa gacaagctca      600

gccgaggtca ccatccagaa tgtcatcaaa ttggtggatg aactgatgga agctcctgga      660

gacgtagagg ccctggcgcc acctgtccgg cacctcatag ccacccagct gctctcaaac      720

cttgaagata tcatgaggat cctggccaag agcctgccta aaggcccctt cacctacatt      780

tccccttcga acacagagct gaccctgatg atccaggagc ggggggacaa gaacgtcact      840

atgggtcaga gcagcgcacg catgaagctg aattgggctg tggcagctgg agccgaggat      900

ccaggccccg ccgtggcggg catcctctcc atccagaaca tgacgacatt gctggccaat      960

gcctccttga acctgcattc caagaagcaa gccgaactgg aggagatata tgaaagcagc     1020

atccgtggtg tccaactcag acgcctctct gccgtcaact ccatctttct gagccacaac     1080

aacaccaagg aactcaactc ccccatcctt ttcgccttct cccaccttga gtcctccgat     1140

ggggaggcgg gaagagaccc tcctgccaag gacgtgatgc ctgggccacg gcaggagctg     1200

ctctgtgcct tctggaagag tgacagcgac aggggagggc actgggccac cgagggctgc     1260

caggtgctgg gcagcaagaa cggcagcacc acctgccaat gcagccacct gagcagcttt     1320

gcgatcctta tggctcatta tgacgtggag gactggaagc tgaccctgat caccagggtg     1380

ggactggcgc tgtcactctt ctgcctgctg ctgtgcatcc tcactttcct gctggtgcgg     1440

cccatccagg gctcgcgcac caccatacac ctgcacctct gcatctgcct cttcgtgggc     1500

tccaccatct tcctggccgg catcgagaac gaaggcggcc aggtggggct gcgctgccgc     1560

ctggtggccg ggctgctgca ctactgtttc ctggccgcct tctgctggat gagcctcgaa     1620

ggcctggagc tctactttct tgtggtgcgc gtgttccaag gccagggcct gagtacgcgc     1680

tggctctgcc tgatcggcta tggcgtgccc ctgctcatcg tgggcgtctc ggctgccatc     1740

tacagcaagg gctacggccg ccccagatac tgctggttgg actttgagca gggcttcctc     1800

tggagcttct tgggacctgt gaccttcatc attttgtgca atgctgtcat tttcgtgact     1860

accgtctgga agctcactca gaagttttct gaaatcaatc cagacatgaa gaaattaaag     1920

aaggcgaggg cgctgaccat cacggccatc gcgcagctct tcctgttggg ctgcacctgg     1980

gtctttggcc tgttcatctt cgacgatcgg agcttggtgc tgacctatgt gtttaccatc     2040

ctcaactgcc tgcagggcgc cttcctctac ctgctgcact gcctgctcaa caagaaggtt     2100

cgggaagaat accggaagtg ggcctgccta gttgctgggg ggagcaagta ctcagaattc     2160

acctccacca cgtctggcac tggccacaat cagacccggg ccctcagggc atcagagtcc     2220

ggcatatga                                                             2229


<210>  238
<211>  642
<212>  DNA
<213>  Homo sapiens;

<400>  238
atgccagacg aaaatatctt cctgttcgtg cccaacctca tcggttatgc ccggattgtc       60

ttcgccatca tttctttcta cttcatgccc tgctgccccc tcacggcctc ctccttctac      120

ctgctcagcg gcctgctgga cgctttcgat ggacacgctg ctcgcgctct taatcaagga      180

acccggtttg gggccatgct ggacatgctg acggaccgct gctccaccat gtgcctgttg      240

gtcaacctgg ccctgctgta ccctggagcc acgctgttct tccaaatcag catgagtttg      300

gatgtggcca gtcactggct gcacctccac agttctgtgg tccgaggcag tgagagtcac      360

aagatgatcg acttgtccgg gaatccggtg cttcggatct actacacctc gaggcctgct      420

ctgttcacct tgtgtgctgg gaatgagctc ttctactgcc tcctctacct gttccatttc      480

tctgagggac ctttagttgg ctctgtggga ctgttccgga tgggcctctg ggtcactgcc      540

cccatcgcct tgctgaagtc gctcatcagc gtcatccacc tgatcacggc cgcccgcaac      600

atggctgccc tggacgcagc agaccgcgcc aagaagaagt ga                         642


<210>  239
<211>  4755
<212>  DNA
<213>  Homo sapiens;

<400>  239
atgagcttaa catcctggtt tttggtgagc agtggaggca ctcgccacag gctgccacga       60

gaaatgattt ttgttggaag agatgactgt gagctcatgt tgcagtctcg tagtgtggat      120

aagcaacacg ctgtcatcaa ctatgatgcg tctacggatg agcatttagt gaaggatttg      180

ggcagcctca atgggacttt tgtgaatgat gtaaggattc cggaacagac ttatatcacc      240

ttgaaacttg aagataagct gagatttgga tatgatacaa atcttttcac tgtagtacaa      300

ggagaaatga gggtccctga agaagctctt aagcatgaga agtttaccat tcagcttcag      360

ttgtcccaaa aatcttcaga atcagaatta tccaaatctg caagtgccaa aagcatagat      420

tcaaaggtag cagacgctgc tactgaagtg cagcacaaaa ctactgaagc actgaaatcc      480

gaggaaaaag ccatggatat ttctgctatg ccccgtggta ctccattata tgggcagccg      540

tcatggtggg gggatgatga ggtggatgaa aaaagagctt tcaagacaaa tggcaaacct      600

gaagaaaaaa accatgaagc tggaacatca gggtgcggca tagatgccaa gcaagttgag      660

gaacaatctg cagctgcaaa tgaagaagta ctttttcctt tctgtaggga accaagttat      720

tttgaaatcc ctacaaaaga attccagcaa ccatcacaaa taacagaaag cactattcat      780

gaaatcccaa caaaagacac gccaagttcc catataacag gtgcagggca tgcttcattt      840

accattgaat ttgatgacag taccccaggg aaggtaacta ttagagacca tgtgacaaag      900

tttacttctg atcagcgcca caagtccaag aagtcttctc ctggaactca agacttgctg      960

gggattcaaa caggaatgat ggcacccgaa aacaaagttg ctgactggct agcacaaaac     1020

aaccctcctc aaatgctatg ggaaagaaca gaagaggatt ctaaaagcat taaaagtgat     1080

gttccagtgt acttgaaaag gttgaaagga aataaacatg atgatggtac gcaaagtgat     1140

tcagagaacg ctggggctca caggcgctgt agcaaacgtg caactcttga ggaacactta     1200

agacgccacc attcagaaca caaaaagcta cagaaggtcc aggctactga aaagcatcaa     1260

gaccaagctg ttactagctc tgcgcatcac agaggggggc atggtgttcc acatgggaaa     1320

ttgttaaaac agaaatcaga ggagccatcg gtgtcaatac ccttcctaca aactgcatta     1380

ttaagaagtt cagggagtct tgggcacaga ccaagccagg agatggataa aatgttaaaa     1440

aatcaagcaa cttctgctac ttctgaaaag gataatgatg atgaccaaag tgacaagggt     1500

acttatacca ttgagttaga gaatcccaac agtgaggaag tggaagcaag aaaaatgatt     1560

gacaaggtgt ttggagtaga tgacaatcag gattataata ggcctgttat caacgaaaaa     1620

cataaagatc taataaaaga ttgggctctc agttctgctg cagcagtaat ggaagaaaga     1680

aaaccactga ctacatctgg atttcaccac tcagaggaag gcacatcttc atctggaagc     1740

aaacgttggg tttcacagtg ggctagtttg gctgccaatc atacaaggca tgatcaagaa     1800

gaaaggataa tggaattttc tgcacctctt cctttagaga atgagacaga gatcagtgag     1860

tctggcatga cagtgagaag tactggctct gcaacttcct tggctagcca gggagagaga     1920

aggagacgaa ctcttcccca gcttccaaat gaagaaaagt ctcttgagag ccacagagca     1980

aaggttgtaa cacagaggtc agagatagga gaaaaacaag acacagaact tcaggagaaa     2040

gaaacaccta cacaggtata ccagaaagat aaacaagatg ctgacagacc cttgagtaaa     2100

atgaacaggg cagtaaatgg agagactctc aaaactggtg gagataataa aaccctactt     2160

cacttaggca gctctgctcc tggaaaagag aaaagtgaaa ctgataagga aacttctttg     2220

gtaaagcaaa cattagcaaa acttcaacaa caagaacaaa gggaggaggc tcagtggaca     2280

cctactaaat tgtcttccaa aaatgtttca ggtcagacag ataaatgtag ggaggaaact     2340

tttaaacaag aatcacaacc tccagaaaaa aattcaggac attctacaag caaaggagac     2400

agagtggcac aaagtgagag caagagaaga aaagctgagg aaattctgaa aagtcagact     2460

ccaaagggag gagacaagaa ggaatcctcc aagtcattag tgcgacaagg gagcttcact     2520

atagaaaaac ccagcccaaa catacccata gaacttattc cccatataaa taaacagact     2580

tcctctactc cttcttcttt agcattaaca tctgcaagta gaatacgaga aagaagtgag     2640

tctttggatc ctgattctag tatggacaca acccttattc taaaagacac agaagcagta     2700

atggcttttc tagaagctaa actacgtgaa gataataaaa ctgatgaagg accagatact     2760

cccagttata atagagacaa ttctatttca ccagaatctg atgtagatac agctagtaca     2820

atcagtctgg ttactggaga aactgaaaga aagtcaaccc aaaagcgaaa gagtttcact     2880

agcctctata aagataggtg ttccacaggt tctccttcca aagatgttac aaaatcatca     2940

tcttcaggtg ctagggaaaa aatggaaaag aaaacaaaaa gtcgttccac agatgtgggt     3000

tcaagagcag atggtcgtaa atttgttcag tccagtggga gaataagaca gccctcagta     3060

gacttaacag atgatgacca aacctctagt gtacctcatt ctgccatctc tgatattatg     3120

tcatctgatc aagaaactta ctcttgtaaa cctcatggac ggactccact tacctcagct     3180

gatgagcatg tacattccaa actggaagga agtaaagtaa cgaaatctaa gacttctccg     3240

gtggtatctg gttcatctag taaatcaacc acccttccaa ggccacgacc taccaggact     3300

tccctcttgc gcagagcacg acttggtgaa gcttcagaca gtgaacttgc tgatgctgac     3360

aaagcatctg ttgcttctga agtatccaca acaagttcta catcaaaacc tcccacagga     3420

aggcgtaaca tctctcggat tgatttattg gctcagcctc gtagaacacg acttggctca     3480

ctgtcagctc gtagtgactc tgaagcaaca atttctagaa gtagtgcctc ttcgaggacc     3540

gcagaagcca tcattagaag tggagccaga ctagtaccat cagataaatt ttctcctaga     3600

attagagcta acagtatctc tcgactctca gactccaagg tcaaaagtat gacctcagct     3660

catggctctg cttcagtaaa ttcaagatgg aggcgctttc ctactgatta tgcttccacc     3720

tcagaagatg aatttggatc aaaccgtaat tcccctaaac atacccgtct acgtacttct     3780

ccagccctga aaaccactcg cttgcagagc gctggatcag caatgcctac tagttcttca     3840

ttcaaacacc ggattaaaga gcaggaagac tacatccgag attggactgc tcatcgagaa     3900

gagatagcca ggatcagcca agatcttgct ctcattgctc gggagatcaa cgatgtagca     3960

ggagagatag attcagtgac ttcatcaggc actgccccta gtaccacagt aagcactgct     4020

gccaccaccc ctggctctgc catagacact agagaagagt tggttgatcg tgtttttgat     4080

gaaagcctca acttccgaaa gattcctcca ttagttcatt ccaaaacacc agaaggaaac     4140

aacggtcgat ctggtgatcc aagacctcaa gcagcagagc ctcccgatca cttaacaatt     4200

acaaggcgga gaacctggag cagggatgaa gtcatgggag ataatctgct gctgtcatcc     4260

gtctttcagt tctctaagaa gataagacaa tctatagata agacagctgg aaagatcaga     4320

atattattta aagacaaaga tcggaattgg gatgacatag aaagcaaatt aagagccgaa     4380

agtgaagtcc ctattgtgaa aacctcaagc atggagattt cttctatctt acaggaactg     4440

aaaagagtag aaaagcagct gcaagcaatc aatgctatga ttgatcctga tggaactttg     4500

gaggctctga acaacatggg atttcccagt gctatgttgc catctccacc gaaacagaag     4560

tccagccctg tgaataacca ccacagcccg ggtcagacac caacacttgg ccaaccagaa     4620

gctagggctc ttcatcctgc tgctgtttca gccgcagctg aatttgagaa tgctgaatct     4680

gaggctgatt tcagtataca tttcaataga ttcaaccccg atggggaaga ggaagatgtt     4740

acagtacaag aatga                                                      4755


<210>  240
<211>  2274
<212>  DNA
<213>  Homo sapiens;

<400>  240
atggccctgg gtgaagaaaa ggcagaagcg gaagcatctg aagacacaaa ggcccagtcc       60

tatgggagag ggagctgcag ggagcgggag ctggacatcc cagggcccat gagtggggag      120

cagcccccac gcctggaagc tgagggaggg ctcatctccc ctgtatgggg ggcagaaggg      180

atacctgccc ctacttgctg gattgggact gaccctggcg gcccctctag agcccaccag      240

ccacaggcca gtgatgccaa cagagagccc gtagctgaga ggtctgagcc tgcactcagt      300

ggcctgcctc ctgccaccat ggggtctgga gaccttctgc tctccgggga aagccaggtg      360

gagaagacca agctttcttc ctccgaggag ttccctcaga ctctgagcct tcccagaaca      420

acaactattt gctcaggaca tgatgctgat accgaagatg atccatccct agcagatttg      480

ccccaggcac tggacctcag ccagcagcct cacagctcag gtctctcttg cctgtcacag      540

tggaagtccg tgctgagccc aggttccgca gctcagcctt ccagctgcag catctctgct      600

tcctccacag gcagcagtct ccagggtcac caggagaggg cggagcctcg tggtggttct      660

ctggccaagg tctcctcctc cctggagccg gtcgtccccc aggaaccttc ctctgtggtg      720

gggctaggac ctcggcccca gtggtcacca cagcctgtgt tctctggggg tgatgcttct      780

gggctaggca ggagacgcct ctccttccag gctgagtact gggcctgtgt gctgccagat      840

tccctgcctc catcacccga ccgccactcc cctctctgga acccaaataa agagtatgaa      900

gatctgcttg actatactta cccactgagg cccgggcctc agctcccaaa gcaccttgat      960

agccgtgtgc cagctgaccc tgtcctgcag gactccgggg tagacctgga tagcttctct     1020

gtctctccag caagcaccct caaatcacct actaatgtct cccccaactg cccaccagca     1080

gaggccactg ccctgccatt ttctgggccc agagagccaa gccttaagca gtggccctcc     1140

agagtacccc agaaacaggg tggcatgggc ttggcatctt ggagccaact tgcatctacc     1200

cccagagccc caggcagtag ggatgctcgt tgggagcgca gagagccagc cctgaggggt     1260

gcgaaggacc ggctgactat aggcaagcac cttgatatgg gctctcccca gctaaggaca     1320

cgggacagag ggtggccctc gcccaggcca gagagggaga agaggaccag ccagagtgcc     1380

cggcgcccta cctgcacaga gtctaggtgg aaatcagaag aggaagtgga aagtgatgac     1440

gagtatcttg ccctccccgc tcggctgaca caggtttcta gcctggtttc gtatctagga     1500

tccatttcta ccttggttac cctgcccact ggggatatca aagggcagag ccccttggaa     1560

gtgtcagaca gtgatgggcc agcttccttc ccttcaagct ccagccaaag ccagcttccc     1620

cctggagctg ccctccaagg atctggggat cctgagggcc agaatccctg tttcctgcgc     1680

tccttcgtcc gtgcccacga ctccgcaggg gaaggcagtc tggggagcag ccaggccctc     1740

ggggtctcct ctggactgct gaaaacacgc ccctccttgc cagctaggtt ggaccggtgg     1800

ccattctcag acccagatgt tgaagggcag cttcccagga aaggaggaga acagggaaaa     1860

gaatcactgg tgcaatgtgt gaagacattt tgctgtcagc tggaagagct gatctgctgg     1920

ctgtataatg ttgcagatgt tactgaccac gggactgcag ccaggtccaa tcttacaagt     1980

ctcaagtctt ctctgcagct ttaccggcaa tttaagaaag atatagatga acatcagtct     2040

ctgacggaga gtgtcttaca gaagggggag attcttcttc agtgcctgtt ggagaacacc     2100

ccagttttag aggatgtcct tgggaggatc gcaaagcagt ctggtgagct ggagagccac     2160

gcagatcgcc tgtatgactc tatcttggcc tctctggaca tgctggctgg ctgcaccctt     2220

atccctgaca aaaagcccat ggcggcaatg gagcacccat gtgaaggggt ttaa           2274


<210>  241
<211>  5901
<212>  DNA
<213>  Homo sapiens;

<400>  241
atgaaggcgg cagacactgt gatcctgtgg gcaagaagta aaaatgacca gctgaggatt       60

tcttttcctc caggactgtg ttggggtgac aggatgcctg ataaggatga cattcggctg      120

ctgccgtcag cattgggtgt gaagaagaga aaacgaggac ccaagaagca gaaggagaac      180

aagccaggaa aaccccgaaa acgcaagaag cgtgacagtg aggaggaatt tggttctgag      240

cgagatgagt accgggagaa gtcagagagt gggggcagtg aatatggaac cggaccgggt      300

cggaaacgaa gaaggaagca ccgagaaaaa aaggagaaga agacaaagcg gcggaaaaag      360

ggggagggag atggggggca aaagcaagtg gaacagaagt catcagcaac tctgcttctg      420

acctggggcc tggaggatgt ggagcatgtg ttctctgagg aggattacca cacgctcacc      480

aactacaaag ccttcagcca gttcatgagg cccctaattg ctaagaagaa tcctaagatc      540

ccaatgtcta agatgatgac catccttggg gccaaatgga gagagttcag tgccaacaac      600

cccttcaagg ggtcagcagc tgctgtggcg gcggcagcgg cagcagcagc agcagctgta      660

gctgagcagg tgtcagctgc tgtctcgtcg gccaccccca tagcaccctc cggacccccc      720

gcccttccac caccccctgc tgctgatatc cagcccccac ccatccgaag agccaaaacc      780

aaagagggca aaggtccagg ccataagagg cggagtaaga gcccccgagt gcctgatgga      840

cgcaagaagc ttcggggaaa gaaaatggca ccactcaaaa taaaactagg gcttctgggt      900

ggcaagagga agaaaggagg ctcgtatgtt tttcagagcg acgaaggtcc tgaaccagag      960

gctgaggaat cagacctgga cagtggcagt gtccacagtg cctcaggccg gcctgatggc     1020

cctgtccgca ccaagaaact aaagagaggc cggccaggaa ggaagaagaa gaaggtcctg     1080

ggctgtcctg cagtggccgg ggaggaggag gttgatggct acgagacgga tcaccaggat     1140

tactgtgagg tgtgccagca gggtggggaa attattctgt gtgacacctg ccctcgtgcc     1200

taccacctcg tctgccttga tcctgagctt gaccgggctc cagagggcaa atggagctgc     1260

cctcactgtg agaaggaggg ggtccagtgg gaggccaagg aggaagaaga agaatacgaa     1320

gaggagggag aggaagaagg ggagaaggag gaggaggatg atcacatgga gtactgccgc     1380

gtatgcaagg acggcgggga gctcctgtgc tgtgacgcgt gcatctcctc ctaccacatt     1440

cattgtctaa accctcccct gcctgacatt cccaatggtg aatggctgtg tccccgatgc     1500

acatgccccg tgctgaaggg tcgagtgcag aagatcctac attggcggtg gggggagcca     1560

cctgtagcag tgccagcccc tcaacaggca gatggaaatc cagatgtccc acccccccgt     1620

cctcttcaag gcagatcaga gcgagagttc tttgtcaagt gggtaggact atcctactgg     1680

cactgctcct gggccaagga gcttcagctg gaaatcttcc atttggttat gtatcgaaac     1740

taccagcgga agaatgacat ggatgagccc ccacccctgg actatggctc cggcgaggat     1800

gatgggaaga gcgacaagcg taaagtgaaa gacccgcact atgctgagat ggaggagaag     1860

tactatcgtt ttggcatcaa gccagagtgg atgaccgtcc accgcatcat caaccacagt     1920

gtggataaaa aggggaatta ccactatcta gtaaaatgga gggacttacc atatgaccag     1980

tccacgtggg aggaagatga aatgaatatc cctgaatacg aagaacataa gcaaagctac     2040

tggagacacc gagaactaat tatgggggaa gaccctgccc agccccgcaa gtataagaag     2100

aagaagaagg agctacaggg tgatgggcct cccagttctc ccactaatga tcctaccgtg     2160

aaatatgaga ctcagccacg gtttatcaca gccactggag gcaccctgca catgtatcag     2220

ttggaagggc tgaactggct acgcttctcc tgggcccagg gcactgacac cattctagct     2280

gatgagatgg ggctaggcaa gaccatacaa accatcgtct tcctctactc actctacaag     2340

gagggccaca caaaaggtcc cttcctggtg agtgccccac tctctaccat cattaactgg     2400

gagcgggagt tccagatgtg ggcacccaaa ttctatgtgg tgacatacac gggtgacaag     2460

gacagccggg ccatcattcg tgagaatgaa ttctcctttg aggacaatgc catcaaaggg     2520

ggcaagaaag cttttaagat gaagagggag gcacaggtga agttccatgt tctcctgaca     2580

tcgtatgagc tgatcaccat tgatcaggca gcacttggtt ccatccgctg ggcctgtctt     2640

gtggtagatg aggcccatcg actcaagaac aaccagtcca agtttttcag ggttctcaat     2700

ggttacaaga tagatcataa gttgctgctg acaggaaccc cattgcagaa taatctggag     2760

gagctcttcc atctcctgaa cttcctcacc ccagagagat ttaacaactt ggagggcttc     2820

ctggaggagt ttgctgacat atccaaagag gaccagatca agaaactgca tgatttgctg     2880

gggccacaca tgctgcggag actcaaggca gatgtcttta agaacatgcc agccaagaca     2940

gagctcatcg ttcgggtgga gctaagcccc atgcagaaga aatactacaa atacatcctg     3000

actcgaaatt ttgaggcctt gaattcacga ggtggtggga accaggtgtc gctgcttaat     3060

atcatgatgg atcttaagaa gtgctgcaac catccatacc tttttcccgt ggctgctatg     3120

gagtccccca aactccccag tggggcttat gagggtgggg cacttattaa gtcgtctggg     3180

aagctcatgc tgctccagaa gatgctgcga aagctgaagg agcaaggaca ccgagtgctc     3240

atcttctcgc agatgaccaa aatgttagac ttgcttgagg acttcttaga ctatgaaggc     3300

tacaagtatg agcgcatcga tggtggtatc acgggtgccc tgaggcagga ggccatcgat     3360

cggtttaatg ctcctggggc ccaacaattc tgcttcctcc tgtccacccg agctgggggc     3420

ctgggcatca atctggccac tgctgacact gtcatcatct ttgattctga ctggaacccc     3480

cataatgaca tccaggcctt tagccgggct catcggattg gccaggccaa caaagtgatg     3540

atttaccggt ttgtgactcg cgcgtcagtg gaagagcgaa tcacacaagt ggccaagaga     3600

aagatgatgc tgacacacct ggttgtgcgg cctgggctgg gctccaaggc aggctccatg     3660

tccaagcagg agcttgacga cattctcaaa tttggcactg aagagctatt caaggatgaa     3720

aacgaggggg agaacaagga ggaggacagc agtgtgattc attatgacaa tgaggccatc     3780

gctcggctgt tggaccggaa ccaggatgca actgaggaca ctgacgtgca gaacatgaat     3840

gagtatctca gctccttcaa ggtggcacag tacgtcgtgc gggaagaaga caagattgag     3900

gaaattgagc gagagatcat caagcaggag gagaatgtgg accctgacta ctgggagaag     3960

ctgctgaggc atcactatga gcaacagcag gaagacctag cccggaatct aggcaagggc     4020

aagcgggttc gcaagcaagt taactacaat gatgctgctc aggaagacca agacaaccag     4080

tcagagtact cggtgggttc agaggaggag gatgaagact tcgatgaacg tcctgaaggg     4140

cgtagacagt caaagaggca gctccggaat gagaaagata agccactgcc tccactgctg     4200

gcccgagtcg ggggcaacat tgaggtgctg ggcttcaaca cccgtcagcg gaaggctttc     4260

ctcaatgctg tgatgcgctg ggggatgcca ccacaggatg ccttcaccac acagtggctg     4320

gtgcgggacc tgaggggcaa gactgagaag gagtttaagg cctatgtgtc tttgttcatg     4380

cgccatctgt gtgagcctgg ggcagacggc tctgaaacct ttgccgatgg ggtccctcgg     4440

gagggactga gtcgccagca ggtgttgacc cgcattggag tcatgtctct cgtcaaaaag     4500

aaggtgcagg agtttgagca catcaatggg cgttggtcaa tgccggaact gatgcctgac     4560

cccagcgccg attctaagcg ctcctccaga gcctcctctc ctaccaaaac gtctcccacc     4620

actcctgagg cttctgctac caacagtccc tgcacctcta aacctgctac tccagctcca     4680

agtgagaaag gagaaggcat aaggacacct cttgagaagg aggaagctga aaaccaggag     4740

gaaaagccag agaagaacag cagaattggg gagaagatgg agacagaggc tgatgccccc     4800

agcccagccc catcacttgg ggagcggctg gagccaagga agattcctct agaggatgag     4860

gtgccagggg tgcctggaga gatggagcct gaacctgggt accgtgggga cagagagaag     4920

tcagaagatg taaaaggtga ccgggagctt cgaccagggc ctcgagatga gccacggtcc     4980

aatgggcgac gagaggaaaa gacagagaag ccccggttca tgttcaatat cgccgatggt     5040

ggcttcacag agcttcacac actgtggcag aatgaggaac gggcagctat ttcctcgggg     5100

aaactcaatg agatctggca cagaagacat gactattggc ttctggctgg gattgtcctc     5160

catggctatg cacggtggca ggacatccag aatgatgctc aatttgccat tatcaacgag     5220

ccatttaaaa ctgaagccaa taaggggaac tttctggaga tgaaaaataa gttcctggcc     5280

cggaggttca agctcctgga gcaggcgctg gtgattgagg agcagctgcg gcgggcggcc     5340

tacctgaacc tgtcgcagga gccggcgcac cccgccatgg ccctccacgc ccgcttcgcc     5400

gaggccgagt gcctggccga gagccaccag cacctctcca aggagtcgct ggcggggaac     5460

aagccggcca acgccgtcct gcacaaggtt ctgaaccagc tggaggagtt gctgagcgac     5520

atgaaggcgg acgtgacccg cctgccagcc acgctgtccc gaataccccc catcgcagcc     5580

cgccttcaga tgtccgagcg cagcatcctc agccggctgg ccagcaaggg cacggagcct     5640

caccccacac cggcctaccc gccgggtccc tacgctacac ctccggggta cggggcggcc     5700

ttcagcgccg cacccgtagg ggccctggcc gccgcaggcg ccaattacag ccagatgcct     5760

gcagggtcct tcatcacagc cgccaccaac ggccctccag tgcttgtgaa gaaggagaag     5820

gaaatggtgg gggcattggt gtcagacggg ctggatcgga aggagccccg agccggggag     5880

gtgatctgta tagacgactg a                                               5901


<210>  242
<211>  600
<212>  DNA
<213>  Homo sapiens;

<400>  242
atgtctaaca tggagaaaca cctgttcaac ctgaagttcg cggccaaaga actgagtagg       60

agtgccaaaa aatgcgataa ggaggaaaag gccgaaaagg ccaaaattaa aaaggccatt      120

cagaagggca acatggaagt tgcgaggata cacgccgaaa atgccatccg ccagaagaac      180

caggcggtga atttcttgag aatgagtgcg cgagtcgatg cagtggctgc cagggtccag      240

acggcggtga cgatgggcaa ggtgaccaag tcgatggctg gtgtggttaa gtcgatggat      300

gcgacattga agaccatgaa tctggagaag atttctgctt tgatggacaa attcgagcac      360

cagtttgaga ctctggacgt ccagacgcag caaatggaag acacgatgag cagcacgacg      420

acgctcacca ctccccagaa ccaagtggat atgctgctcc aggaaatggc agatgaggcg      480

ggcctcgacc tcaacatgga gctgccgcag ggccagaccg gctccgtggg cacgagcgtg      540

gcttcggcgg agcaggatga actgtctcag agactggccc gccttcggga tcaagtgtga      600


<210>  243
<211>  1362
<212>  DNA
<213>  Homo sapiens;

<400>  243
atgtggtccc cggagcggga ggccgaggcc ccagccgggg gagacccggc gggccttctg       60

ccccccgagt gggaggagga cgaggagcgc atgtccttcc tgttctccgc tttcaagagg      120

agtcgcgagg tgaacagcac cgactgggac agcaagatgg gcttctgggc gccgttggtg      180

ctgagccaca gccgccgcca gggggtggtg cgcctgcgtc tgcgggactt gcaggaggcc      240

tttcagcgca aggggagcgt cccgctgggg ctggccacgg tgctgcagga cctgctgcgt      300

cgaggggagc tgcagcggga gtcagacttc atggccagtg tagacagcag ctggatctcc      360

tggggggttg gggtcttcct gctgaagcct ctcaagtgga ctctttctaa catgctggga      420

gataataagg ttccagctga ggaggtcctt gtcgctgtgg agctgttgaa ggaaaaggct      480

gaggaggtgt atcgtctgta tcagaactcg cccctctcct cccaccccgt ggtggccctg      540

tcagagctca gcaccctctg tgctaactcc tgcccagatg agaggacctt ctacttggtg      600

ttgctgcagc tgcagaagga gaagagggtc acagtcctcg agcagaacgg ggagaagatt      660

gtgaagtttg cccgagggcc acgtgccaag gtctctccag tcaatgacgt agatgttggg      720

gtgtaccagc tgatgcagag tgaacagctt ctctcacgca aagtggagtc cttatcccag      780

gaagcagaga ggtgtaaaga agaagcccgc cgggcatgcc gagcaggaaa gaagcagctg      840

gcactgaggt ctctcaaggc caagcaacgg acagagaagc gcatcgaggc cttgcatgcc      900

aagctggaca ctgttcaagg catcctggac cggatctatg cctcccagac agatcagatg      960

gtttttaacg cctaccaggc tggggtagga gcactcaaac tctccatgaa ggatgtcaca     1020

gtggagaagg cagagagcct cgtggatcag atccaagagc tctgtgacac ccaggatgaa     1080

gtttctcaga ctctggctgg tggggtaaca aatggcttag attttgacag tgaagaactg     1140

gagaaggaat tggacatcct ccttcaggat accaccaaag aacctttgga tctgcctgac     1200

aacccccgca ataggcattt taccaacagc gtgcctaacc ctaggatctc agatgctgaa     1260

cttgaagctg aacttgagaa actgtcctta tcagagggag gtttggtccc aagcagtaaa     1320

tctccaaaaa ggcaattgga accgactcta aagccattgt ag                        1362


<210>  244
<211>  1059
<212>  DNA
<213>  Homo sapiens;

<400>  244
atgaagccag cgctgctgga agtgatgagg atgaacagaa tctgccggat ggtgctggcc       60

acttgcttgg gatcctttat cctggtcatc ttctatttcc aaagtatgtt gcacccagtc      120

atgcggagga atccctttgg tgtggacatc tgctgccgga aggggtcccg aagccccctg      180

caggaactct acaacccaat ccagctggag ctctcaaaca ctgctgtcct gcaccagatg      240

cggcgggacc aggtgacaga cacgtgccga gccaacagcg ccacaagccg taagcggagg      300

gtgctgaccc ccaacgacct gaagcacttg gtggtggatg aggaccacga gctcatctac      360

tgctacgtgc ccaaggtggc ctgcaccaac tggaagcggc tcatgatggt cctgaccggg      420

cgggggaagt acagcgaccc catggagatc ccggccaacg aggcacacgt ctccgccaac      480

ctgaagaccc tgaaccagta cagcatccca gaaatcaacc accgcttgaa aagctacatg      540

aagttcctgt ttgtccggga gcccttcgag aggctagtgt ccgcctaccg caacaagttc      600

acccagaagt acaacatctc cttccacaag cggtacggca ccaagatcat caaacgccag      660

cggaagaacg ccacccagga ggccctgcgc aaaggggacg atgtcaaatt cgaggagttt      720

gtggcctatc tcatcgaccc acacacccag cgggaggagc ctttcaacga acactggcaa      780

accgtctact cactctgcca tccctgccac atccactatg acctcgtggg caagtacgag      840

acactggaag aggattctaa ttacgtcctg cagctggcag gagtgggcag ctacctgaag      900

ttccccacct atgcaaagtc tacgagaact actgatgaaa tgaccacaga attcttccag      960

aacatcagct cagagcacca aacgcagctg tacgaagtct acaaactcga ttttttaatg     1020

ttcaattact cagtgccaag ctacctgaaa ttggaataa                            1059


<210>  245
<211>  939
<212>  DNA
<213>  Homo sapiens;

<400>  245
atggcagatt ttgggatctc tgctggccag tttgtggcag tggtctggga taagtcatcc       60

ccagtggagg ctctgaaagg tctggtggat aagcttcaag cgttaaccgg caatgagggc      120

cgcgtgtctg tggaaaacat caagcagctg ttgcaatctg cccacaaaga atccagcttt      180

gacattattt tgtcaggttt agtcccagga agcaccactc tgcacagtgc tgagattttg      240

gctgaaatcg cccggatcct tcggcctggt ggatgtcttt ttctgaagga gccagtagag      300

acagctgtag ataacaatag caaagtgaag acagcatcta agctgtgttc agccctgact      360

ctttctggtc ttgtggaagt gaaagagctg cagcgggagc ccctaacccc tgaggaagta      420

cagtctgttc gagaacacct tggtcatgaa agtgacaacc tgctgtttgt tcagatcaca      480

ggcaaaaaac caaactttga agtgggttct tctaggcagc ttaagctttc catcaccaag      540

aagtcttctc cttcagtgaa acctgctgtg gaccctgctg ctgccaagct gtggaccctc      600

tcagccaacg atatggagga cgacagcatg gatctcattg actcagatga gctgctggat      660

ccagaagatt tgaagaagcc agatccagct tccctgcggg ctgcttcttg tggggaaggg      720

aaaaagagga aggcctgtaa gaactgcacc tgtggccttg ccgaagaact ggaaaaagag      780

aagtcaaggg aacagatgag ctcccaaccc aagtcagctt gtggaaactg ctacctgggc      840

gatgccttcc gctgtgccag ctgcccctac cttgggatgc cagccttcaa acctggggaa      900

aaggtgcttc tgagtgatag caatcttcat gatgcctag                             939


<210>  246
<211>  714
<212>  DNA
<213>  Homo sapiens;

<400>  246
atgacttcgg aaatcactta tgctgaagtg aggttcaaaa atgaattcaa gtcctcaggc       60

atcaacacag cctcttctgc agcttccaag gagaggactg cccctcacaa aagtaatacc      120

ggattcccca agctgctttg tgcctcactg ttgatatttt tcctgctatt ggcaatctca      180

ttctttattg cttttgtcat tttctttcaa aaatattctc agcttcttga aaaaaagact      240

acaaaagagc tggttcatac aacattggag tgtgtgaaaa aaaatatgcc cgtggaagag      300

acagcctgga gctgttgccc aaagaattgg aagtcattta gttccaactg ctactttatt      360

tctactgaat cagcatcttg gcaagacagt gagaaggact gtgctagaat ggaggctcac      420

ctgctggtga taaacactca agaagagcag gatttcatct tccagaatct gcaagaagaa      480

tctgcttatt ttgtggggct ctcagatcca gaaggtcagc gacattggca atgggttgat      540

cagacaccat acaatgaaag ttccacattc tggcatccac gtgagcccag tgatcccaat      600

gagcgctgcg ttgtgctaaa ttttcgtaaa tcacccaaaa gatggggctg gaatgatgtt      660

aattgtcttg gtcctcaaag gtcagtttgt gagatgatga agatccactt atga            714


<210>  247
<211>  1446
<212>  DNA
<213>  Homo sapiens;

<400>  247
atgcggcatt ccaaaagaac tcactgtcct gattgggata gcagagaaag ctggggacat       60

gaaagctatc gtggaagtca caagcggaag aggagatctc atagtagcac acaagagaac      120

aggcattgta aaccacatca ccagtttaaa gaatctgatt gtcattattt agaagcaagg      180

tccttgaatg agcgagatta tcgggaccgg agatacgttg acgaatacag gaatgactac      240

tgtgaaggat atgttcctag acattatcac agagacattg aaagcgggta tcgaatccac      300

tgcagtaaat cttcagtccg cagcaggaga agcagtccta aaaggaagcg caatagacac      360

tgttcaagtc atcagtcacg ttcgaagagc caccgaagga aaagatccag gagtatagag      420

gatgatgagg agggtcacct gatctgtcaa agtggagacg ttctaagagc aagatatgaa      480

atcgtggaca ctttgggtga aggagccttt ggcaaagttg tagagtgcat tgatcatggc      540

atggatggca tgcatgtagc agtgaaaatc gtaaaaaatg taggccgtta ccgtgaagca      600

gctcgttcag aaatccaagt attagagcac ttaaatagta ctgatcccaa tagtgtcttc      660

cgatgtgtcc agatgctaga atggtttgat catcatggtc atgtttgtat tgtgtttgaa      720

ctactgggac ttagtactta cgatttcatt aaagaaaaca gctttctgcc atttcaaatt      780

gaccacatca ggcagatggc gtatcagatc tgccagtcaa taaatttttt acatcataat      840

aaattaaccc atacagatct gaagcctgaa aatattttgt ttgtgaagtc tgactatgta      900

gtcaaatata attctaaaat gaaacgtgat gaacgcacac tgaaaaacac agatatcaaa      960

gttgttgact ttggaagtgc aacgtatgat gatgaacatc acagtacttt ggtgtctacc     1020

cggcactaca gagctcccga ggtcattttg gctttaggtt ggtctcagcc ttgtgatgtt     1080

tggagcatag gttgcattct tattgaatat taccttggtt tcacagtctt tcagactcat     1140

gatagtaaag agcacctggc aatgatggaa cgaatattag gacccatacc acaacacatg     1200

attcagaaaa caagaaaacg caagtatttt caccataacc agctagattg ggatgaacac     1260

agttctgctg gtagatatgt taggagacgc tgcaaaccgt tgaaggaatt tatgctttgt     1320

catgatgaag aacatgagaa actgtttgac ctggttcgaa gaatgttaga atatgatcca     1380

actcaaagaa ttaccttgga tgaagcattg cagcatcctt tctttgactt attaaaaaag     1440

aaatga                                                                1446


<210>  248
<211>  837
<212>  DNA
<213>  Homo sapiens;

<400>  248
atggattcaa tgcctgagcc cgcgtcccgc tgtcttctgc ttcttccctt gctgctgctg       60

ctgctgctgc tgctgccggc cccggagctg ggcccgagcc aggccggagc tgaggagaac      120

gactgggttc gcctgcccag caaatgcgaa gtgtgtaaat atgttgctgt ggagctgaag      180

tcagcctttg aggaaaccgg caagaccaag gaggtgattg gcacgggcta tggcatcctg      240

gaccagaagg cctctggagt caaatacacc aagtcggact tgcggttaat cgaagtcact      300

gagaccattt gcaagaggct cctggattat agcctgcaca aggagaggac cggcagcaat      360

cgatttgcca agggcatgtc agagaccttt gagacattac acaacctggt acacaaaggg      420

gtcaaggtgg tgatggacat cccctatgag ctgtggaacg agacttctgc agaggtggct      480

gacctcaaga agcagtgtga tgtgctggtg gaagagtttg aggaggtgat cgaggactgg      540

tacaggaacc accaggagga agacctgact gaattcctct gcgccaacca cgtgctgaag      600

ggaaaagaca ccagttgcct ggcagagcag tggtccggca agaagggaga cacagctgcc      660

ctgggaggga agaagtccaa gaagaagagc agcagggcca aggcagcagg cggcaggagt      720

agcagcagca aacaaaggaa ggagctgggt ggccttgagg gagaccccag ccccgaggag      780

gatgagggca tccagaaggc atcccctctc acacacagcc cccctgatga gctctga         837


<210>  249
<211>  984
<212>  DNA
<213>  Homo sapiens;

<400>  249
atgaccatgg aatctggagc cgagaaccag cagagtggag atgcagctgt aacagaagct       60

gaaaaccaac aaatgacagt tcaagcccag ccacagattg ccacattagc ccaggtatct      120

atgccagcag ctcatgcaac atcatctgct cccaccgtaa ctctagtaca gctgcccaat      180

gggcagacag ttcaagtcca tggagtcatt caggcggccc agccatcagt tattcagtct      240

ccacaagtcc aaacagttca gatttcaact attgcagaaa gtgaagattc acaggagtca      300

gtggatagtg taactgattc ccaaaagcga agggaaattc tttcaaggag gccttcctac      360

aggaaaattt tgaatgactt atcttctgat gcaccaggag tgccaaggat tgaagaagag      420

aagtctgaag aggagacttc agcacctgcc atcaccactg taacggtgcc aactccaatt      480

taccaaacta gcagtggaca gtatattgcc attacccagg gaggagcaat acagctggct      540

aacaatggta ccgatggggt acagggcctg caaacattaa ccatgaccaa tgcagcagcc      600

actcagccgg gtactaccat tctacagtat gcacagacca ctgatggaca gcagatctta      660

gtgcccagca accaagttgt tgttcaagct gcctctggag acgtacaaac ataccagatt      720

cgcacagcac ccactagcac tattgcccct ggagttgtta tggcatcctc cccagcactt      780

cctacacagc ctgctgaaga agcagcacga aagagagagg tccgtctaat gaagaacagg      840

gaagcagctc gagagtgtcg tagaaagaag aaagaatatg tgaaatgttt agaaaacaga      900

gtggcagtgc ttgaaaatca aaacaagaca ttgattgagg agctaaaagc acttaaggac      960

ctttactgcc acaaatcaga ttaa                                             984


<210>  250
<211>  7329
<212>  DNA
<213>  Homo sapiens;

<400>  250
atggctgaga acttgctgga cggaccgccc aaccccaaaa gagccaaact cagctcgccc       60

ggtttctcgg cgaatgacag cacagatttt ggatcattgt ttgacttgga aaatgatctt      120

cctgatgagc tgatacccaa tggaggagaa ttaggccttt taaacagtgg gaaccttgtt      180

ccagatgctg cttccaaaca taaacaactg tcggagcttc tacgaggagg cagcggctct      240

agtatcaacc caggaatagg aaatgtgagc gccagcagcc ccgtgcagca gggcctgggt      300

ggccaggctc aagggcagcc gaacagtgct aacatggcca gcctcagtgc catgggcaag      360

agccctctga gccagggaga ttcttcagcc cccagcctgc ctaaacaggc agccagcacc      420

tctgggccca cccccgctgc ctcccaagca ctgaatccgc aagcacaaaa gcaagtgggg      480

ctggcgacta gcagccctgc cacgtcacag actggacctg gtatctgcat gaatgctaac      540

tttaaccaga cccacccagg cctcctcaat agtaactctg gccatagctt aattaatcag      600

gcttcacaag ggcaggcgca agtcatgaat ggatctcttg gggctgctgg cagaggaagg      660

ggagctggaa tgccgtaccc tactccagcc atgcagggcg cctcgagcag cgtgctggct      720

gagaccctaa cgcaggtttc cccgcaaatg actggtcacg cgggactgaa caccgcacag      780

gcaggaggca tggccaagat gggaataact gggaacacaa gtccatttgg acagcccttt      840

agtcaagctg gagggcagcc aatgggagcc actggagtga acccccagtt agccagcaaa      900

cagagcatgg tcaacagttt gcccaccttc cctacagata tcaagaatac ttcagtcacc      960

aacgtgccaa atatgtctca gatgcaaaca tcagtgggaa ttgtacccac acaagcaatt     1020

gcaacaggcc ccactgcaga tcctgaaaaa cgcaaactga tacagcagca gctggttcta     1080

ctgcttcatg ctcataagtg tcagagacga gagcaagcaa acggagaggt tcgggcctgc     1140

tcgctcccgc attgtcgaac catgaaaaac gttttgaatc acatgacgca ttgtcaggct     1200

gggaaagcct gccaagttgc ccattgtgca tcttcacgac aaatcatctc tcattggaag     1260

aactgcacac gacatgactg tcctgtttgc ctccctttga aaaatgccag tgacaagcga     1320

aaccaacaaa ccatcctggg gtctccagct agtggaattc aaaacacaat tggttctgtt     1380

ggcacagggc aacagaatgc cacttcttta agtaacccaa atcccataga ccccagctcc     1440

atgcagcgag cctatgctgc tctcggactc ccctacatga accagcccca gacgcagctg     1500

cagcctcagg ttcctggcca gcaaccagca cagcctcaaa cccaccagca gatgaggact     1560

ctcaaccccc tgggaaataa tccaatgaac attccagcag gaggaataac aacagatcag     1620

cagcccccaa acttgatttc agaatcagct cttccgactt ccctgggggc cacaaaccca     1680

ctgatgaacg atggctccaa ctctggtaac attggaaccc tcagcactat accaacagca     1740

gctcctcctt ctagcaccgg tgtaaggaaa ggctggcacg aacatgtcac tcaggacctg     1800

cggagccatc tagtgcataa actcgtccaa gccatcttcc caacacctga tcccgcagct     1860

ctaaaggatc gccgcatgga aaacctggta gcctatgcta agaaagtgga aggggacatg     1920

tacgagtctg ccaacagcag ggatgaatat tatcacttat tagcagagaa aatctacaag     1980

atacaaaaag aactagaaga aaaacggagg tcgcgtttac ataaacaagg catcttgggg     2040

aaccagccag ccttaccagc cccgggggct cagccccctg tgattccaca ggcacaacct     2100

gtgagacctc caaatggacc cctgtccctg ccagtgaatc gcatgcaagt ttctcaaggg     2160

atgaattcat ttaaccccat gtccttgggg aacgtccagt tgccacaagc acccatggga     2220

cctcgtgcag cctccccaat gaaccactct gtccagatga acagcatggg ctcagtgcca     2280

gggatggcca tttctccttc ccgaatgcct cagcctccga acatgatggg tgcacacacc     2340

aacaacatga tggcccaggc gcccgctcag agccagtttc tgccacagaa ccagttcccg     2400

tcatccagcg gggcgatgag tgtgggcatg gggcagccgc cagcccaaac aggcgtgtca     2460

cagggacagg tgcctggtgc tgctcttcct aaccctctca acatgctggg gcctcaggcc     2520

agccagctac cttgccctcc agtgacacag tcaccactgc acccaacacc gcctcctgct     2580

tccacggctg ctggcatgcc atctctccag cacacgacac cacctgggat gactcctccc     2640

cagccagcag ctcccactca gccatcaact cctgtgtcgt cttccgggca gactcccacc     2700

ccgactcctg gctcagtgcc cagtgctacc caaacccaga gcacccctac agtccaggca     2760

gcagcccagg cccaggtgac cccgcagcct caaaccccag ttcagccccc gtctgtggct     2820

acccctcagt catcgcagca acagccgacg cctgtgcacg cccagcctcc tggcacaccg     2880

ctttcccagg cagcagccag cattgataac agagtcccta ccccctcctc ggtggccagc     2940

gcagaaacca attcccagca gccaggacct gacgtacctg tgctggaaat gaagacggag     3000

acccaagcag aggacactga gcccgatcct ggtgaatcca aaggggagcc caggtctgag     3060

atgatggagg aggatttgca aggagcttcc caagttaaag aagaaacaga catagcagag     3120

cagaaatcag aaccaatgga agtggatgaa aagaaacctg aagtgaaagt agaagttaaa     3180

gaggaagaag agagtagcag taacggcaca gcctctcagt caacatctcc ttcgcagccg     3240

cgcaaaaaaa tctttaaacc agaggagtta cgccaggccc tcatgccaac cctagaagca     3300

ctgtatcgac aggacccaga gtcattacct ttccggcagc ctgtagatcc ccagctcctc     3360

ggaattccag actattttga catcgtaaag aatcccatgg acctctccac catcaagcgg     3420

aagctggaca cagggcaata ccaagagccc tggcagtacg tggacgacgt ctggctcatg     3480

ttcaacaatg cctggctcta taatcgcaag acatcccgag tctataagtt ttgcagtaag     3540

cttgcagagg tctttgagca ggaaattgac cctgtcatgc agtcccttgg atattgctgt     3600

ggacgcaagt atgagttttc cccacagact ttgtgctgct atgggaagca gctgtgtacc     3660

attcctcgcg atgctgccta ctacagctat cagaataggt atcatttctg tgagaagtgt     3720

ttcacagaga tccagggcga gaatgtgacc ctgggtgacg acccttcaca gccccagacg     3780

acaatttcaa aggatcagtt tgaaaagaag aaaaatgata ccttagaccc cgaacctttc     3840

gttgattgca aggagtgtgg ccggaagatg catcagattt gcgttctgca ctatgacatc     3900

atttggcctt caggttttgt gtgcgacaac tgcttgaaga aaactggcag acctcgaaaa     3960

gaaaacaaat tcagtgctaa gaggctgcag accacaagac tgggaaacca cttggaagac     4020

cgagtgaaca aatttttgcg gcgccagaat caccctgaag ccggggaggt ttttgtccga     4080

gtggtggcca gctcagacaa gacggtggag gtcaagcccg ggatgaagtc acggtttgtg     4140

gattctgggg aaatgtctga atctttccca tatcgaacca aagctctgtt tgcttttgag     4200

gaaattgacg gcgtggatgt ctgctttttt ggaatgcacg tccaagaata cggctctgat     4260

tgcccccctc caaacacgag gcgtgtgtac atttcttatc tggatagtat tcatttcttc     4320

cggccacgtt gcctccgcac agccgtttac catgagatcc ttattggata tttagagtat     4380

gtgaagaaat tagggtatgt gacagggcac atctgggcct gtcctccaag tgaaggagat     4440

gattacatct tccattgcca cccacctgat caaaaaatac ccaagccaaa acgactgcag     4500

gagtggtaca aaaagatgct ggacaaggcg tttgcagagc ggatcatcca tgactacaag     4560

gatattttca aacaagcaac tgaagacagg ctcaccagtg ccaaggaact gccctatttt     4620

gaaggtgatt tctggcccaa tgtgttagaa gagagcatta aggaactaga acaagaagaa     4680

gaggagagga aaaaggaaga gagcactgca gccagtgaaa ccactgaggg cagtcagggc     4740

gacagcaaga atgccaagaa gaagaacaac aagaaaacca acaagaacaa aagcagcatc     4800

agccgcgcca acaagaagaa gcccagcatg cccaacgtgt ccaatgacct gtcccagaag     4860

ctgtatgcca ccatggagaa gcacaaggag gtcttcttcg tgatccacct gcacgctggg     4920

cctgtcatca acaccctgcc ccccatcgtc gaccccgacc ccctgctcag ctgtgacctc     4980

atggatgggc gcgacgcctt cctcaccctc gccagagaca agcactggga gttctcctcc     5040

ttgcgccgct ccaagtggtc cacgctctgc atgctggtgg agctgcacac ccagggccag     5100

gaccgctttg tctacacctg caacgagtgc aagcaccacg tggagacgcg ctggcactgc     5160

actgtgtgcg aggactacga cctctgcatc aactgctata acacgaagag ccatgcccat     5220

aagatggtga agtgggggct gggcctggat gacgagggca gcagccaggg cgagccacag     5280

tcaaagagcc cccaggagtc acgccggctg agcatccagc gctgcatcca gtcgctggtg     5340

cacgcgtgcc agtgccgcaa cgccaactgc tcgctgccat cctgccagaa gatgaagcgg     5400

gtggtgcagc acaccaaggg ctgcaaacgc aagaccaacg ggggctgccc ggtgtgcaag     5460

cagctcatcg ccctctgctg ctaccacgcc aagcactgcc aagaaaacaa atgccccgtg     5520

cccttctgcc tcaacatcaa acacaagctc cgccagcagc agatccagca ccgcctgcag     5580

caggcccagc tcatgcgccg gcggatggcc accatgaaca cccgcaacgt gcctcagcag     5640

agtctgcctt ctcctacctc agcaccgccc gggaccccca cacagcagcc cagcacaccc     5700

cagacgccgc agccccctgc ccagccccaa ccctcacccg tgagcatgtc accagctggc     5760

ttccccagcg tggcccggac tcagcccccc accacggtgt ccacagggaa gcctaccagc     5820

caggtgccgg cccccccacc cccggcccag ccccctcctg cagcggtgga agcggctcgg     5880

cagatcgagc gtgaggccca gcagcagcag cacctgtacc gggtgaacat caacaacagc     5940

atgcccccag gacgcacggg catggggacc ccggggagcc agatggcccc cgtgagcctg     6000

aatgtgcccc gacccaacca ggtgagcggg cccgtcatgc ccagcatgcc tcccgggcag     6060

tggcagcagg cgccccttcc ccagcagcag cccatgccag gcttgcccag gcctgtgata     6120

tccatgcagg cccaggcggc cgtggctggg ccccggatgc ccagcgtgca gccacccagg     6180

agcatctcac ccagcgctct gcaagacctg ctgcggaccc tgaagtcgcc cagctcccct     6240

cagcagcaac agcaggtgct gaacattctc aaatcaaacc cgcagctaat ggcagctttc     6300

atcaaacagc gcacagccaa gtacgtggcc aatcagcccg gcatgcagcc ccagcctggc     6360

ctccagtccc agcccggcat gcaaccccag cctggcatgc accagcagcc cagcctgcag     6420

aacctgaatg ccatgcaggc tggcgtgccg cggcccggtg tgcctccaca gcagcaggcg     6480

atgggaggcc tgaaccccca gggccaggcc ttgaacatca tgaacccagg acacaacccc     6540

aacatggcga gtatgaatcc acagtaccga gaaatgttac ggaggcagct gctgcagcag     6600

cagcagcaac agcagcagca acaacagcag caacagcagc agcagcaagg gagtgccggc     6660

atggctgggg gcatggcggg gcacggccag ttccagcagc ctcaaggacc cggaggctac     6720

ccaccggcca tgcagcagca gcagcgcatg cagcagcatc tccccctcca gggcagctcc     6780

atgggccaga tggcggctca gatgggacag cttggccaga tggggcagcc ggggctgggg     6840

gcagacagca cccccaacat ccagcaagcc ctgcagcagc ggattctgca gcaacagcag     6900

atgaagcagc agattgggtc cccaggccag ccgaacccca tgagccccca gcaacacatg     6960

ctctcaggac agccacaggc ctcgcatctc cctggccagc agatcgccac gtcccttagt     7020

aaccaggtgc ggtctccagc ccctgtccag tctccacggc cccagtccca gcctccacat     7080

tccagcccgt caccacggat acagccccag ccttcgccac accacgtctc accccagact     7140

ggttcccccc accccggact cgcagtcacc atggccagct ccatagatca gggacacttg     7200

gggaaccccg aacagagtgc aatgctcccc cagctgaaca cccccagcag gagtgcgctg     7260

tccagcgaac tgtccctggt cggggacacc acgggggaca cgctagagaa gtttgtggag     7320

ggcttgtag                                                             7329


<210>  251
<211>  1329
<212>  DNA
<213>  Homo sapiens;

<400>  251
atgagggggg cgatggagct ggagcctgag ctgctgttgc aggaggcccg cgagaacgtg       60

gaggcagcgc agagctaccg gcgggagctg ggtcaccggc ttgaggggct gcgtgaggcg      120

cggaggcaga tcaaagaaag tgcatcacag acaagggatg ttctcaaaca gcattttaat      180

gatttaaagg gaacccttgg aaagctcctg gatgagcgat tggtgaccct tttgcaagag      240

gtggacacca ttgaacagga gaccattaaa ccactagatg actgccagaa gctcatagaa      300

cacggagtca acactgcaga ggacttagtc cgagaaggtg aaatcgccat gcttggtggt      360

gtgggagaag agaatgagaa actgtggagc tttaccaaaa aggcctcgca cattcagttg      420

gacagcttac cagaagtacc tttactggtt gatgtgcctt gtttatctgc tcagttggat      480

gactcaattc ttaacatagt gaaagaccac atttttaagc atggaacagt agcatctcgc      540

ccaccagtac agatagaaga actaatagag aaacctggag gcatcattgt acgatggtgt      600

aaggtggatg atgactttac agcccaagat tacaggctcc agtttcgtaa atgtacttca      660

aatcattttg aggatgtata tgtaggttct gaaactgaat tcatagtatt gcacatagac      720

cccaacgttg attaccagtt cagagtctgc gcccgaggag atggccgaca ggagtggagt      780

ccttggagtg tcccccagat aggtcattcc acattggtgc ctcatgagtg gacagctggt      840

tttgaggggt acagtctgag cagtcgaaga aatatagcac ttcggaacga ttctgaatca      900

tcgggtgttc tctactccag agctccgact tatttctgtg ggcagacatt aacattcaga      960

gttgaaactg tgggacagcc agacagaaga gatagcatag gagtgtgtgc agaaaaacag     1020

gatggatatg actctctgca gcgggatcaa gctgtgtgca ttagtacaaa tggtgcagtt     1080

tttgtcaatg gaaaagaaat gacaaatcag ttacccgcag ttacttctgg gtccactgtc     1140

acgtttgaca ttgaagccgt gactctagga accaccagta ataatgaagg tggacacttc     1200

aagcttcgag taactataag ttcaaataat agagaagtgg tttttgactg gttacttgat     1260

cagtcttgtg gttctcttta ctttggatgc tcatttttct atcctggatg gaaagtgtta     1320

gtgttttag                                                             1329


<210>  252
<211>  1860
<212>  DNA
<213>  Homo sapiens;

<400>  252
atggccgcct cgccgggctc gggcagcgcc aacccgcgga agttcagtga gaagatcgcg       60

ctgcacacgc agagacaggc cgaggagacg cgggccttcg agcagctcat gaccgacctc      120

accctgtcgc gggttcaatt tcagaagctt cagcaactgc gccttacaca gtaccatgga      180

ggatccttac caaatgtgag ccagctgcgg agcagtgcgt cagagtttca gccgtcattt      240

caccaagctg ataatgttcg gggaacccgc catcacgggc tggtggagag gccatccagg      300

aaccgcttcc accccctcca ccgaaggtct ggggacaagc cagggcgaca atttgatggt      360

agtgcttttg gagccaatta ttcctcacag cctctggatg agagttggcc aaggcagcag      420

cctccttgga aagacgaaaa gcatcctggg ttcaggctga catctgcact taacaggacc      480

aattctgatt ctgctcttca cacgagtgct ctgagtacca agccccagga cccctatgga      540

ggagggggcc agtcggcctg gcctgcccca tacatgggtt tctgtgatgg tgagaataat      600

ggacatgggg aagtagcatc tttccctggc ccattgaaag aagagaatct gttaaatgtt      660

ccgaagccac tgccaaaaca actgtgggag accaaggaga ttcagtccct gtcaggacgc      720

cctcgatcct gtgatgttgg aggtggcaat gcttttccac ataatggtca aaacctaggc      780

ctctcaccct tcttggggac cttgaacact ggagggtcat tgccagatct aaccaacctc      840

cactactcga cacccctgcc agcctccctg gacaccaccg accaccactt tggcagtatg      900

agtgtgggga atagtgtgaa caacatccca gctgctatga cccacctggg tataagaagc      960

tcctctggtc tccagagttc tcggagtaac ccctccatcc aagccacgct caataagact     1020

gtgctttcct cttccttaaa taaccaccca cagacatctg ttcccaacgc atctgctctt     1080

cacccttcgc tccgtctgtt ttcccttagc aacccatctc tttccaccac aaacctgagc     1140

ggcccgtctc ggcgtcggca gcctcccgtc agccctctca cgctttctcc tggccctgaa     1200

gcacatcaag gtttcagcag acagctgtct tcaaccagcc cactggcccc atatcctacc     1260

tcccagatgg tgtcctcaga ccgaagccaa ctttcctttc tgcccacaga agctcaagcc     1320

caggtgtcgc cgccaccccc ttaccctgca ccccaggagc tcacccagcc cctcctgcag     1380

cagccccgcg cccctgaggc ccctgcccag cagccccagg cagcctcctc actgccacag     1440

tcagactttc agcttctccc ggcccagggc tcatctttga ccaacttctt cccagatgtg     1500

ggttttgacc agcagtccat gaggccaggc cctgcctttc ctcaacaggt gcctctggtg     1560

caacaaggtt cccgagaact gcaggactct tttcatttga gaccaagccc gtattccaac     1620

tgcgggagtc tcccgaacac catcctgcca gaagactcca gcaccagcct gttcaaagac     1680

ctcaacagtg cgctggcagg cctgcctgag gtcagcctga acgtggacac tccatttcca     1740

ctggaagagg agctgcagat tgaacccctg agcctggacg gactcaacat gttaagtgac     1800

tccagcatgg gcctgctgga cccctctgtt gaagagacgt ttcgagctga cagactgtga     1860


<210>  253
<211>  1563
<212>  DNA
<213>  Homo sapiens;

<400>  253
atgtcaattc cactgaagtc ctcatttctg ctgagctacc tgtgcaccct gcctccggct       60

ctcctgagca gagagatcct gatggctgac tcagaagcac tcccctccct tgctggggac      120

ccagtggctg tggaagcctt gctccgggcc gtgtttgggg ttgttgtgga tgaggccatt      180

cagaaaggaa ccagtgtctc ccagaaggtc tgtgagtgga aggagcctga ggagctgaag      240

cagctgctgg atttggagct gcggagccag ggcgagtcac agaagcagat cctggagcgg      300

tgtcgggctg tgattcgcta cagtgtcaag actggtcacc ctcggttctt caaccagctc      360

ttctctgggt tggatcccca tgctctggcc gggcgcatta tcactgagag cctcaacacc      420

agccagtaca catatgaaat cgcccccgtg tttgtgctca tggaagagga ggtgctgagg      480

aaactgcggg ccctggtggg ctggagctct ggggacggaa tcttctgccc tggtggctcc      540

atctccaaca tgtatgctgt aaatctggcc cgctatcagc gctacccgga ttgcaagcag      600

aggggcctcc gcacactgcc gcccctggcc ctattcacat cgaaggagtg tcactactcc      660

atccagaagg gagctgcgtt tctgggactt ggcaccgaca gtgtccgagt ggtcaaggct      720

gatgagagag ggaaaatggt ccccgaggat ctggagaggc agattggtat ggccgaggct      780

gagggtgctg tgccgttcct ggtcagtgcc acctctggca ccactgtgct aggggccttt      840

gaccccctgg aggcaattgc tgatgtgtgc cagcgtcatg ggctatggct gcatgtggat      900

gctgcctggg gtgggagcgt cctgctgtca cagacacaca ggcatctcct ggatgggatc      960

cagagggctg actctgtggc ctggaatccc cacaagctcc tcgcagcagg cctgcaatgc     1020

tctgcacttc ttctccagga tacctcgaac ctgctcaagc gctgccatgg gtcccaggcc     1080

agctaccttt tccagcagga caagttctac gatgtggctc tggacacggg agacaaggtg     1140

gtgcagtgtg gccgccgtgt ggactgtctg aagctgtggc tcatgtggaa ggcacagggc     1200

gatcaagggc tggagcggcg catcgaccag gcctttgtcc ttgcccggta cctggtggag     1260

gaaatgaaga agcgggaagg gtttgagcta gtcatggagc ctgagtttgt caatgtgtgt     1320

ttctggttcg taccccccag cctgcgaggg aagcaggaga gtccagatta ccacgaaagg     1380

ctgtcaaagg tggcccccgt gctcaaggag cgcatggtga aggagggctc catgatgatt     1440

ggctaccagc cccacgggac ccggggcaac ttcttccgtg tggttgtggc caactctgca     1500

ctgacctgtg ctgatatgga cttcctcctc aacgagctgg agcggctagg ccaggacctg     1560

tga                                                                   1563


<210>  254
<211>  2694
<212>  DNA
<213>  Homo sapiens;

<400>  254
atggtgctgg cccaggggct gctctccatg gccctgctgg ccctgtgctg ggagcgcagc       60

ctggcagggg cagaagaaac catcccgctg cagaccctgc gctgctacaa cgactacacc      120

agccacatca cctgcaggtg ggcagacacc caggatgccc agcggctcgt caacgtgacc      180

ctcattcgcc gggtgaatga ggacctcctg gagccagtgt cctgtgacct cagtgatgac      240

atgccctggt cagcctgccc ccatccccgc tgcgtgccca ggagatgtgt cattccctgc      300

cagagttttg tcgtcactga cgttgactac ttctcattcc aaccagacag gcctctgggc      360

acccggctca ccgtcactct gacccagcat gtccagcctc ctgagcccag ggacctgcag      420

atcagcaccg accaggacca cttcctgctg acctggagtg tggcccttgg gagtccccag      480

agccactggt tgtccccagg ggatctggag tttgaggtgg tctacaagcg gcttcaggac      540

tcttgggagg acgcagccat cctcctctcc aacacctccc aggccaccct ggggccagag      600

cacctcatgc ccagcagcac ctacgtggcc cgagtacgga cccgcctggc cccaggttct      660

cggctctcag gacgtcccag caagtggagc ccagaggttt gctgggactc ccagccaggg      720

gatgaggccc agccccagaa cctggagtgc ttctttgacg gggccgccgt gctcagctgc      780

tcctgggagg tgaggaagga ggtggccagc tcggtctcct ttggcctatt ctacaagccc      840

agcccagatg caggggagga agagtgctcc ccagtgctga gggaggggct cggcagcctc      900

cacaccaggc accactgcca gattcccgtg cccgaccccg cgacccacgg ccaatacatc      960

gtctctgttc agccaaggag ggcagagaaa cacataaaga gctcagtgaa catccagatg     1020

gcccctccat ccctcaacgt gaccaaggat ggagacagct acagcctgcg ctgggaaaca     1080

atgaaaatgc gatacgaaca catagaccac acatttgaga tccagtacag gaaagacacg     1140

gccacgtgga aggacagcaa gaccgagacc ctccagaacg cccacagcat ggccctgcca     1200

gccctggagc cctccaccag gtactgggcc agggtgaggg tcaggacctc ccgcaccggc     1260

tacaacggga tctggagcga gtggagtgag gcgcgctcct gggacaccga gtcggtgctg     1320

cctatgtggg tgctggccct catcgtgatc ttcctcacca tcgctgtgct cctggccctc     1380

cgcttctgtg gcatctacgg gtacaggctg cgcagaaagt gggaggagaa gatccccaac     1440

cccagcaaga gccacctgtt ccagaacggg agcgcagagc tttggccccc aggcagcatg     1500

tcggccttca ctagcgggag tcccccacac caggggccgt ggggcagccg cttccctgag     1560

ctggaggggg tgttccctgt aggattcggg gacagcgagg tgtcacctct caccatagag     1620

gaccccaagc atgtctgtga tccaccatct gggcctgaca cgactccagc tgcctcagat     1680

ctacccacag agcagccccc cagcccccag ccaggcccgc ctgccgcctc ccacacacct     1740

gagaaacagg cttccagctt tgacttcaat gggccctacc tggggccgcc ccacagccgc     1800

tccctacctg acatcctggg ccagccggag cccccacagg agggtgggag ccagaagtcc     1860

ccacctccag ggtccctgga gtacctgtgt ctgcctgctg gggggcaggt gcaactggtc     1920

cctctggccc aggcgatggg accaggacag gccgtggaag tggagagaag gccgagccag     1980

ggggctgcag ggagtccctc cctggagtcc gggggaggcc ctgcccctcc tgctcttggg     2040

ccaagggtgg gaggacagga ccaaaaggac agccctgtgg ctatacccat gagctctggg     2100

gacactgagg accctggagt ggcctctggt tatgtctcct ctgcagacct ggtattcacc     2160

ccaaactcag gggcctcgtc tgtctcccta gttccctctc tgggcctccc ctcagaccag     2220

acccccagct tatgtcctgg gctggccagt ggaccccctg gagccccagg ccctgtgaag     2280

tcagggtttg agggctatgt ggagctccct ccaattgagg gccggtcccc caggtcacca     2340

aggaacaatc ctgtcccccc tgaggccaaa agccctgtcc tgaacccagg ggaacgcccg     2400

gcagatgtgt ccccaacatc cccacagccc gagggcctcc ttgtcctgca gcaagtgggc     2460

gactattgct tcctccccgg cctggggccc ggccctctct cgctccggag taaaccttct     2520

tccccgggac ccggtcctga gatcaagaac ctagaccagg cttttcaagt caagaagccc     2580

ccaggccagg ctgtgcccca ggtgcccgtc attcagctct tcaaagccct gaagcagcag     2640

gactacctgt ctctgccccc ttgggaggtc aacaagcctg gggaggtgtg ttga           2694


<210>  255
<211>  1248
<212>  DNA
<213>  Homo sapiens;

<400>  255
atggagctga gagtcgggaa caggtaccgg ctgggccgga agatcggcag cggctccttc       60

ggagacatct atctcggtac ggacattgct gcaggagaag aggttgccat caagcttgaa      120

tgtgtcaaaa ccaaacaccc tcagctccac attgagagca aaatctacaa gatgatgcag      180

ggaggagtgg gcatccccac catcagatgg tgcggggcag agggggacta caacgtcatg      240

gtgatggagc tgctggggcc aagcctggag gacctcttca acttctgctc caggaaattc      300

agcctcaaaa ccgtcctgct gcttgctgac caaatgatca gtcgcatcga atacattcat      360

tcaaagaact tcatccaccg ggatgtgaag ccagacaact tcctcatggg cctggggaag      420

aagggcaacc tggtgtacat catcgacttc gggctggcca agaagtaccg ggatgcacgc      480

acccaccagc acatccccta tcgtgagaac aagaacctca cggggacggc gcggtacgcc      540

tccatcaaca cgcaccttgg aattgaacaa tcccgaagag atgacttgga gtctctgggc      600

tacgtgctaa tgtacttcaa cctgggctct ctcccctggc aggggctgaa ggctgccacc      660

aagagacaga aatacgaaag gattagcgag aagaaaatgt ccacccccat cgaagtgttg      720

tgtaaaggct acccttccga atttgccaca tacctgaatt tctgccgttc cttgcgtttt      780

gacgacaagc ctgactactc gtacctgcgg cagcttttcc ggaatctgtt ccatcgccag      840

ggcttctcct atgactacgt gttcgactgg aacatgctca aatttggtgc cagccgggcc      900

gccgatgacg ccgagcggga gcgcagggac cgagaggagc ggctgagaca ctcgcggaac      960

ccggctaccc gcggcctccc ttccacagcc tccggccgcc tgcgggggac gcaggaagtg     1020

gctcccccca cacccctcac ccctacctca cacacggcta acacctcccc ccggcccgtc     1080

tccggcatgg agagagagcg gaaagtgagt atgcggctgc accgcggggc ccccgtcaac     1140

atctcctcgt ccgacctcac aggccgacaa gatacctctc gcatgtccac ctcacagatt     1200

cctggtcggg tggcttccag tggtcttcag tctgtcgtgc accgatga                  1248


<210>  256
<211>  441
<212>  DNA
<213>  Homo sapiens;

<400>  256
atggccgggc ccctgcgcgc cccgctgctc ctgctggcca tcctggccgt ggccctggcc       60

gtgagccccg cggccggctc cagtcccggc aagccgccgc gcctagtggg aggccccatg      120

gacgccagcg tggaggagga gggtgtgcgg cgtgcactgg actttgccgt cggcgagtac      180

aacaaagcca gcaacgacat gtaccacagc cgcgcgctgc aggtggtgcg cgcccgcaag      240

cagatcgtag ctggggtgaa ctacttcttg gacgtggagc tgggccgaac cacgtgtacc      300

aagacccagc ccaacttgga caactgcccc ttccatgacc agccacatct gaaaaggaaa      360

gcattctgct ctttccagat ctacgctgtg ccttggcagg gcacaatgac cttgtcgaaa      420

tccacctgtc aggacgccta g                                                441


<210>  257
<211>  1338
<212>  DNA
<213>  Homo sapiens;

<400>  257
atggcccttg tggataagca caaagtcaag agacagcgat tggacagaat ttgtgaaggt       60

atccgccccc agatcatgaa cggccccctg cacccccgcc ccctggtggc gctgctggac      120

ggccgcgact gcactgtgga gatgcccatc ctgaaggacc tggccactgt ggccttctgt      180

gacgcgcagt cgacgcagga aatccacgag aaggttctaa acgaagccgt gggcgccatg      240

atgtaccaca ccatcaccct caccagggag gacctggaga agttcaaggc cctgagagtg      300

atcgtgcgga taggcagtgg ctatgacaac gtggacatca aggctgccgg cgagctcgga      360

attgccgtgt gcaacatccc gtctgcagcc gtggaagaga cagcggactc taccatctgc      420

cacatcctca acctgtaccg gaggaacacg tggctgtacc aggcactgcg ggaaggcacg      480

cgggttcaga gcgtggagca gatccgcgag gtggcctcgg gagcggcccg catccgtggg      540

gagacgctgg gcctcattgg ctttggtcgc acggggcagg cggttgcagt tcgagccaag      600

gcctttggat tcagcgtcat attttatgac ccctacttgc aggatgggat cgagcggtcc      660

ctgggcgtgc agagggtcta caccctgcag gatttgctgt atcagagcga ctgcgtctcc      720

ttgcactgca atctcaacga acataaccac cacctcatca atgactttac cataaagcag      780

atgaggcagg gagcattcct tgtgaacgca gcccgtggcg gcctggtgga cgagaaagcc      840

ttagcacaag ccctcaagga gggcaggata cgaggggcag ccctcgacgt gcatgagtca      900

gagcccttca gctttgctca gggtccgttg aaagatgccc cgaatctcat ctgcactcct      960

cacactgcct ggtacagtga gcaggcgtca ctggagatga gggaggcagc tgccaccgag     1020

atccgccgag ccatcacagg tcgcatccca gaaagcttaa gaaattgtgt gaacaaggaa     1080

ttctttgtca catcagcgcc ttggtcagta atagaccagc aagcaattca tcctgagctc     1140

aatggtgcca catacagata tccgccaggc atcgtgggtg tggctccagg aggacttcct     1200

gcagccatgg aagggatcat ccctggaggc atcccagtga ctcacaacct cccgacagtg     1260

gcacatcctt cccaagcgcc ctctcccaac cagcccacaa aacacgggga caatcgagag     1320

caccccaacg agcaatag                                                   1338


<210>  258
<211>  816
<212>  DNA
<213>  Homo sapiens;

<400>  258
atggaacacg gctccatcat cacccaggcg cggagggaag acgccctggt gctcaccaag       60

caaggcctgg tctccaagtc ctctcctaag aagcctcgtg gacgtaacat cttcaaggcc      120

cttttctgct gttttcgcgc ccagcatgtt ggccagtcaa gttcctccac tgagctcgct      180

gcgtataagg aggaagcaaa caccattgct aagtcggatc tgctccagtg tctccagtac      240

cagttctacc agatcccagg gacctgcctg ctcccagagg tgacagagga agatcaagga      300

aggatctgtg tggtcattga cctcgatgaa acccttgtgc atagctcctt taagccaatc      360

aacaatgctg acttcatagt gcctatagag attgagggga ccactcacca ggtgtatgtg      420

ctcaagaggc cttatgtgga tgagttcctg agacgcatgg gggaactctt tgaatgtgtt      480

ctcttcactg ccagcctggc caagtatgcc gaccctgtga cagacctgct ggaccggtgt      540

ggggtgttcc gggcccgcct attccgtgag tcttgcgtgt tccaccaggg ctgctacgtc      600

aaggacctca gccgcctggg gagggacctg agaaagaccc tcatcctgga caactcgcct      660

gcttcttaca tattccaccc cgagaatgca gtgcctgtgc agtcctggtt tgatgacatg      720

gcagacactg agttgctgaa cctgatccca atctttgagg agctgagcgg agcagaggac      780

gtctacacca gccttgggca gctgcgggcc ccttag                                816


<210>  259
<211>  2331
<212>  DNA
<213>  Homo sapiens;

<400>  259
atgtcgtcaa cccggagcca gaacccccac ggcctgaagc agattggcct ggaccagatc       60

tgggacgacc tcagagccgg catccagcag gtgtacacac ggcagagcat ggccaagtcc      120

agatatatgg agctctacac tcatgtttat aactactgta ctagtgttca ccagtcaaac      180

caagcacgag gagctggagt tcctccttct aagtcgaaaa aggggcagac acctggagga      240

gctcagtttg ttggcctgga attatataaa cgacttaagg aatttttgaa gaattacttg      300

acaaatcttc ttaaggatgg agaagatttg atggatgaga gtgtactgaa attctacact      360

caacaatggg aagattatcg attttcaagc aaagtgctga atggaatttg tgcctacctc      420

aatagacatt gggttcgccg tgaatgtgac gaaggacgaa aaggaatata tgaaatctat      480

tcgcttgcat tggtgacttg gagagactgt ctgttcaggc cactgaataa acaggtaaca      540

aatgctgttt taaagctgat tgaaaaggaa aggaatggtg aaaccatcaa tacaagattg      600

attagtggag ttgtacagtc ttacgtggaa ttggggctga atgaagatga tgcatttgca      660

aagggcccta cgttaacagt gtataaagaa tcctttgaat ctcaattttt ggctgacaca      720

gagagatttt ataccagaga gagtactgaa ttcttgcagc agaacccagt tactgaatat      780

atgaaaaagg cagaggctcg tctgcttgag gaacaacgaa gagttcaggt ttaccttcat      840

gaaagcacac aagatgaatt agcaaggaaa tgtgaacaag tcctcattga aaaacacttg      900

gaaattttcc acacagaatt tcagaattta ttggatgctg acaaaaatga agatttggga      960

cgcatgtata atcttgtatc tagaatccag gatggcctag gagaattgaa aaaactgttg     1020

gagacacaca ttcataatca gggtcttgca gccattgaaa agtgtggaga agctgcttta     1080

aatgacccca aaatgtatgt acagacagtg cttgatgttc ataaaaaata caatgccctg     1140

gtaatgtctg cattcaacaa tgacgctggc tttgtggctg ctcttgataa ggcttgtggt     1200

cgcttcataa acaacaacgc ggttaccaag atggcccaat catccagtaa atcccctgag     1260

ttgctggctc gatactgtga ctccttgttg aagaaaagtt ccaagaaccc agaggaggca     1320

gaactagaag acacactcaa tcaagtgatg gttgtcttca agtacataga agacaaagac     1380

gtatttcaga agttctatgc gaagatgctc gccaagaggc tcgtccacca gaacagtgca     1440

agtgacgatg ccgaagccag catgatctcc aagttaaagc aagcttgcgg gttcgagtac     1500

acctctaaac ttcagcgcat gtttcaagac attggcgtga gcaaagatct gaacgagcaa     1560

ttcaaaaagc acttgacaaa ctcagaaccc ctagacttgg atttcagcat tcaagtgctg     1620

agctccgggt cctggccctt ccagcagtct tgtacatttg ccttgccgtc agagttggaa     1680

cgtagttatc agcgattcac agctttctac gccagccgcc acagtggccg aaaattgacg     1740

tggttatatc agttgtctaa aggagaattg gtaactaact gcttcaaaaa cagatatact     1800

ttgcaggcgt cgacattcca gatggctatc ctgcttcagt acaacacgga agatgcctac     1860

actgtgcagc agctgaccga cagcactcaa attaaaatgg acattttggc gcaagtttta     1920

cagattttat taaagtcgaa gctattggtc ttggaagatg aaaatgcaaa tgttgatgag     1980

gtggaattga agccagatac cttaataaaa ttatatcttg gttataaaaa taagaaatta     2040

agggttaaca tcaatgtgcc aatgaaaacc gaacagaagc aggaacaaga aaccacacac     2100

aaaaacatcg aggaagaccg caaactactg attcaggcgg ccatcgtgag aatcatgaag     2160

atgaggaagg ttctgaaaca ccagcagtta cttggcgagg tcctcactca gctgtcctcc     2220

aggttcaaac ctcgagtccc tgtgatcaag aaatgcattg acattctaat tgagaaagaa     2280

tatttggagc gagtggatgg tgaaaaggac acctacagtt acttggctta a              2331


<210>  260
<211>  2871
<212>  DNA
<213>  Homo sapiens;

<400>  260
atgagttcag gcttatggag ccaagaaaaa gtcacttcac cctactggga agagcggatt       60

ttttacttgc ttcttcaaga atgcagcgtt acagacaaac aaacacaaaa gctccttaaa      120

gtaccgaagg gaagtatagg acagtatatt caagatcgtt ctgtggggca ttcaaggatt      180

ccttctgcaa aaggcaagaa aaatcagatt ggattaaaaa ttctagagca acctcatgca      240

gttctctttg ttgatgaaaa ggatgttgta gagataaatg aaaagttcac agagttactt      300

ttggcaatta ccaattgtga ggagaggttc agcctgttta aaaacagaaa cagactaagt      360

aaaggcctcc aaatagacgt gggctgtcct gtgaaagtac agctgagatc tggggaagaa      420

aaatttcctg gagttgtacg cttcagagga cccctgttag cagagaggac agtctccgga      480

atattctttg gagttgaatt gctggaagaa ggtcgtggtc aaggtttcac tgacggggtg      540

taccaaggga aacagctttt tcagtgtgat gaagattgtg gcgtgtttgt tgcattggac      600

aagctagaac tcatagaaga tgatgacact gcattggaaa gtgattacgc aggtcctggg      660

gacacaatgc aggtcgaact tcctcctttg gaaataaact ccagagtttc tttgaaggtt      720

ggagaaacaa tagaatctgg aacagttata ttctgtgatg ttttgccagg aaaagaaagc      780

ttaggatatt ttgttggtgt ggacatggat aaccctattg gcaactggga tggaagattt      840

gatggagtgc agctttgtag ttttgcgtgt gttgaaagta caattctatt gcacatcaat      900

gatatcatcc cagctttatc agagagtgtg acgcaggaaa ggaggcctcc caaacttgcc      960

tttatgtcaa gaggtgttgg ggacaaaggt tcatccagtc ataataaacc aaaggctaca     1020

ggatctacct cagaccctgg aaatagaaac agatctgaat tattttatac cttaaatggg     1080

tcttctgttg actcacaacc acaatccaaa tcaaaaaata catggtacat tgatgaagtt     1140

gcagaagacc ctgcaaaatc tcttacagag atatctacag actttgaccg ttcttcacca     1200

ccactccagc ctcctcctgt gaactcactg accaccgaga acagattcca ctctttacca     1260

ttcagtctca ccaagatgcc caataccaat ggaagtattg gccacagtcc actttctctg     1320

tcagcccagt ctgtaatgga agagctaaac actgcacccg tccaagagag tccacccttg     1380

gccatgcctc ctgggaactc acatggtcta gaagtgggct cattggctga agttaaggag     1440

aaccctcctt tctatggggt aatccgttgg atcggtcagc caccaggact gaatgaagtg     1500

ctcgctggac tggaactgga agatgagtgt gcaggctgta cggatggaac cttcagaggc     1560

actcggtatt tcacctgtgc cctgaagaag gcgctgtttg tgaaactgaa gagctgcagg     1620

cctgactcta ggtttgcatc attgcagccg gtttccaatc agattgagcg ctgtaactct     1680

ttagcatttg gaggctactt aagtgaagta gtagaagaaa atactccacc aaaaatggaa     1740

aaagaaggct tggagataat gattgggaag aagaaaggca tccagggtca ttacaattct     1800

tgttacttag actcaacctt attctgctta tttgctttta gttctgttct ggacactgtg     1860

ttacttagac ccaaagaaaa gaacgatgta gaatattata gtgaaaccca agagctactg     1920

aggacagaaa ttgttaatcc tctgagaata tatggatatg tgtgtgccac aaaaattatg     1980

aaactgagga aaatacttga aaaggtggag gctgcatcag gatttacctc tgaagaaaaa     2040

gatcctgagg aattcttgaa tattctgttt catcatattt taagggtaga acctttgcta     2100

aaaataagat cagcaggtca aaaggtacaa gattgttact tctatcaaat ttttatggaa     2160

aaaaatgaga aagttggcgt tcccacaatt cagcagttgt tagaatggtc ttttatcaac     2220

agtaacctga aatttgcaga ggcaccatca tgtctgatta ttcagatgcc tcgatttgga     2280

aaagacttta aactatttaa aaaaattttt ccttctctgg aattaaatat aacagattta     2340

cttgaagaca ctcccagaca gtgccggata tgtggagggc ttgcaatgta tgagtgtaga     2400

gaatgctacg acgatccgga catctcagct ggaaaaatca agcagttttg taaaacctgc     2460

aacactcaag tccaccttca tccgaagagg ctgaatcata aatataaccc agtgtcactt     2520

cccaaagact tacccgactg ggactggaga cacggctgca tcccttgcca gaatatggag     2580

ttatttgctg ttctctgcat agaaacaagc cactatgttg cttttgtgaa gtatgggaag     2640

gacgattctg cctggctctt ctttgacagc atggccgatc gggatggtgg tcagaatggc     2700

ttcaacattc ctcaagtcac cccatgccca gaagtaggag agtacttgaa gatgtctctg     2760

gaagacctgc attccttgga ctccaggaga atccaaggct gtgcacgaag actgctttgt     2820

gatgcatata tgtgcatgta ccagagtcca acaatgagtt tgtacaaata a              2871


<210>  261
<211>  1185
<212>  DNA
<213>  Homo sapiens;

<400>  261
atggacctgt gccacccaga gcccgcggag ctgagcagcg gggagacgga agagttacag       60

aggatcaagt ggcaccgaaa gcagctcctg gaggacatcc agaagctgaa ggatgagatt      120

gcagatgtgt ttgcccaaat cgactgcttc gagagtgcgg aggagagccg gatggcccag      180

aaggagaagg agctgtgtat tgggcgcaag aagttcaaca tggaccccgc caagggtatc      240

cagtatttca ttgagcacaa gctgctgacc cctgacgtcc aggacattgc acggttcctg      300

tataaaggcg agggcctcaa caagacagcc attggtacct acctggggga gagggatccc      360

atcaacctgc aggtcctcca ggccttcgtg gactgccacg agttcgccaa cctcaacctc      420

gtccaggccc tcaggcagtt cctgtggagc ttccggctgc cgggcgaggc ccagaagata      480

gaccggatga tggaggcctt tgccactcga tactgcctct gcaacccagg cgtcttccag      540

tccacagaca cctgctacgt gttgtccttc tccatcatca tgctcaacac cagcctccac      600

aatcccaacg tccgggacag gccgcctttt gagcgctttg tgtccatgaa ccgcggcatc      660

aacaatggta gcgacctgcc cgaggaccag ctgcggaacc tcttcgacag catcaagagt      720

gagccattct ccatccctga ggacgacggc aatgacctca ctcacacctt cttcaatcca      780

gaccgggagg gttggctgct caagctaggg ggccgcgtga agacgtggaa acggcgctgg      840

ttcatcctga ccgacaactg cctctactac ttcgagttca ccactgacaa ggagccacgg      900

ggaattatac ctcttgagaa cctctcggtg cagaaggtgg atgaccccaa gaagccattc      960

tgcctggagc tctacaaccc tagctgccga ggccagaaaa tcaaggcctg caagaccgat     1020

ggcgacggca gggtggtgga gggcaagcac gaatcgtacc gcatctcagc caccagtgcc     1080

gaggaacgtg accagtggat cgagtccatc cgagccagca tcacccgtgt ccccttctac     1140

gacctggtct ctactcggaa gaagaagatt gccagcaagc agtga                     1185


<210>  262
<211>  1263
<212>  DNA
<213>  Homo sapiens;

<400>  262
atggagacca aacgggtgga gattcccggc agcgtcctgg acgatctctg cagccgattt       60

attttgcata ttcccagcga ggaaagagac aatgcaatcc gagtgtgttt tcagattgaa      120

cttgcccatt ggttttactt ggatttctac atgcagaaca caccaggatt acctcagtgt      180

gggataagag actttgctaa agctgtcttc agtcattgtc cgtttttgct gcctcaaggt      240

gaagatgtgg aaaaagtttt ggatgaatgg aaggaatata aaatgggagt accaacatat      300

ggtgcaatta ttcttgatga gacacttgaa aatgtactac tagttcaggg gtacctagca      360

aaatcaggct ggggatttcc aaaaggaaaa gtaaataaag aagaagctcc tcatgattgt      420

gctgctagag aggtctttga agaaactggt tttgatatca aagactatat ttgtaaggat      480

gattacattg aacttcgaat caatgaccag cttgctcgtt tgtacatcat tccaggaatt      540

ccaaaagaca caaaatttaa cccaaaaact agaagagaaa ttcggaacat tgagtggttc      600

tctattgaga aattgccttg tcatagaaat gatatgaccc ccaaatccaa acttggtttg      660

gcacctaaca aattttttat ggccattccc tttatcagac cattaaggga ctggctttct      720

cgaagatttg gcgattcctc agacagtgac aatggatttt cctcaactgg tagcacgccg      780

gctaaaccca ctgtggaaaa attgagtcga accaaattcc gccacagtca gcagttattt      840

cctgacggtt ctcctggtga ccagtgggta aagcacaggc aaccactgca gcaaaagcca      900

tataataatc attctgaaat gtctgacctt ttaaaaggaa agaatcaaag tatgagggga      960

aatggcagaa aacagtatca agattcacct aatcaaaaga aaagaacaaa tgggcttcag     1020

ccagcaaagc agcagaattc tttgatgaag tgtgaaaaga aacttcatcc acggaaactt     1080

caggataatt ttgaaacaga tgctgtatat gacttgccta gctccagtga agaccagttg     1140

ctagaacatg ctgagggaca gcccgtggca tgtaatggac attgcaagtt ccccttttca     1200

tccagagcct ttttgagttt caagtttgac cataatgcta taatgaaaat cttggacctt     1260

tga                                                                   1263


<210>  263
<211>  5139
<212>  DNA
<213>  Homo sapiens;

<400>  263
atggaaagaa atgttcttac aacattttca caggaaatgt cccagttaat tttgaatgaa       60

atgccaaaag ctgaatattc cagtttattc aatgattttg ttgaatctga attttttttg      120

attgatgggg attcattact tatcacatgt atctgtgaga tatcatttaa gcctgggcag      180

aacctccatt tcttctatct ggttgaacgc tatcttgtgg atcttattag caaaggagga      240

caattcacca tagttttctt caaggatgcc gagtatgcgt atttcaactt ccctgaactt      300

ctttctttga gaactgcttt aattcttcat cttcagaaga ataccaccat tgatgttcga      360

acaacatttt cgagatgctt atcaaaagag tggggaagtt tcttggaaga gagttaccca      420

tatttcctga tagttgcaga cgaaggcctg aacgatctac aaacacagct tttcaacttt      480

ttaatcattc attcttgggc aaggaaggtc aacgttgtac tttcctcagg gcaagaatct      540

gatgttcttt gcctttatgc ataccttctt ccaagcatgt acagacacca gattttttcc      600

tggaagaata agcagaacat taaagatgct tatacaaccc tgcttaacca gttggaaaga      660

tttaagcttt cagcattagc acctcttttt ggaagtttaa aatggaataa tattacggaa      720

gaggcacaca agactgtatc tctgcttaca caagtctggc cagaaggatc tgacattcgg      780

cgtgtctttt gtgttacttc atgctcatta tctttgagaa tgtaccatcg ctttttagga      840

aacagagagc cctcctctgg tcaggaaact gagatccaac aggtgaacag taattgctta      900

accctgcagg agatggaaga tttgtgtaaa ctgcattgtc tcactgtggt ttttctactc      960

catctgcctc tttctcaaag agcttgtgct agagtcatca cttcccattg ggctgaggac     1020

atgaagcctt tattacaaat gaaaaagtgg tgtgaatatt tcatcttaag aaatatacat     1080

acttttgaat tttggaatct gaatttaatt cacctttctg acttaaatga tgagcttttg     1140

ttgaagaata ttgcttttta ctatgaaaat gaaaatgtaa aaggcctaca tttgaatttg     1200

ggagatacca ttatgaaaga ttatgaatat ctctggaata ccgtatcaaa gttggtcaga     1260

gactttgagg ttggacagcc atttcctctg agaacaacaa aagtttgttt tcttgaaaag     1320

aaaccatcac caatcaaaga cagctccaat gaaatggtgc ccaatttggg ttttattcca     1380

acgtcatctt ttgtggttga taaatttgct ggagatattt tgaaagattt gccttttcta     1440

aagagtgatg atcctattgt tacttcactg gttaaacaaa aggaatttga tgaacttgtg     1500

cactggcatt ctcataaacc cctgagtgat gattatgaca ggtccaggtg tcagtttgat     1560

gaaaaatcta gagaccctcg tgttcttaga tctgtgcaaa agtatcatgt tttccaacgg     1620

ttttatggga attcattaga aacagtctct tcgaaaatca tcgtgactca aactattaag     1680

tcaaagaagg attttagtgg gcccaagagc aaaaaggcac acgagaccaa ggctgaaata     1740

attgctagag agaataagaa aaggttattt gccagggaag aacaaaagga agagcaaaag     1800

tggaatgctt tgtcattttc tattgaagag caattgaaag aaaatttaca ctctggaata     1860

aagagcctgg aagatttttt gaaatcctgt aaaagtagct gtgtgaaact tcaggttgaa     1920

atggtggggt taactgcttg cttgaaagcc tggaaagaac attgccgaag tgaagaaggt     1980

aaaaccacga aagatttaag tatagctgtt caggtgatga aaaggatcca ctccttgatg     2040

gaaaaatact cagaactttt acaagaagat gatcggcaac tcatagccag atgccttaag     2100

tatttaggat ttgatgagtt ggcaagttct ttacatccag cccaggatgc agaaaatgat     2160

gtaaaagtga agaaaaggaa taaatattca gttggcattg ggccagctcg gttccaactg     2220

caatacatgg gccattattt gatacgagat gagagaaaag acccagatcc cagggtccag     2280

gattttattc ccgacacatg gcagcgagag ctccttgatg ttgtggataa gaatgagtca     2340

gcagtgattg ttgccccaac gtcctcaggc aaaacctatg cctcctacta ctgtatggag     2400

aaagtgctga aggagagcga cgacggggtg gtcgtgtacg ttgcacccac aaaggccctt     2460

gttaatcaag tggcagcaac tgttcagaat cgttttacga aaaatctgcc aagtggtgaa     2520

gttctctgtg gtgttttcac cagggagtat cgtcatgatg ccttaaactg tcaggtactt     2580

attacagtgc ctgcctgctt tgaaattctg ctgcttgctc ctcatcgcca aaactgggtg     2640

aaaaagatca gatatgttat atttgatgag gttcattgtc ttggtggaga aattggagca     2700

gaaatctggg aacatctcct tgtcatgatc cgatgtccct ttttggctct ttcagctacc     2760

ataagtaatc ctgaacatct caccgagtgg ctacaatcgg taaaatggta ctggaaacaa     2820

gaagacaaaa taattgaaaa taataccgct tctaaaagac atgtgggtcg tcaggccggc     2880

tttcccaaag actacttgca agtaaaacaa tcgtataaag ttagacttgt gctctatgga     2940

gagaggtata atgatctaga gaagcatgta tgttcaataa aacatggtga cattcatttt     3000

gatcattttc acccatgtgc tgcactaaca acagatcata ttgaaaggta tggattccct     3060

cctgatctta ccctttcacc tcgagaaagc atccagctgt atgatgccat gtttcaaatt     3120

tggaaaagtt ggcctcgggc ccaggaactg tgcccagaaa acttcattca ttttaacaat     3180

aaattagtca ttaaaaagat ggatgctagg aaatatgaag agagtctaaa ggcagaatta     3240

acaagttgga ttaaaaatgg caacgtagag caggccagaa tggtacttca gaatcttagt     3300

cctgaagcag atttgagtcc agaaaacatg atcaccatgt ttccacttct agttgaaaaa     3360

ctaaggaaaa tggagaagtt acctgcacta ttttttttat tcaagttagg agctgtagaa     3420

aacgcagctg aaagtgtgag cactttccta aagaaaaagc aggagacaaa aaggcctccc     3480

aaagctgata aagaagccca tgtcatggct aacaaacttc gaaaagttaa aaaatccata     3540

gagaaacaaa agatcataga tgaaaagagc cagaaaaaaa ccagaaatgt ggatcaaagc     3600

ctaatacatg aagctgaaca tgataatcta gtgaagtgtc tagagaagaa cctggaaatc     3660

ccacaggact gcacatatgc tgatcaaaaa gcagtggaca ctgagacttt gcagaaggta     3720

tttggtcgag taaaatttga aagaaaaggt gaagaattga aagccttggc agaaaggggt     3780

attggatatc atcacagtgc tatgagtttc aaagaaaaac aattagttga aatcctcttt     3840

agaaaaggat atcttagggt ggtgacagct actggaacac ttgctttagg tgtcaacatg     3900

ccttgtaaat ctgtggtttt tgctcaaaac tcagtctatc tggatgcgtt gaattataga     3960

cagatgtctg gccgtgctgg aagaagaggt caagacctga tgggagatgt atatttcttt     4020

gatattccat tccccaaaat aggaaaactc ataaaatcca atgttcctga gctgagagga     4080

cacttccctc tcagcataac cctggtcctg cgactcatgc tgctggcttc caagggagat     4140

gacccagagg atgccaaggc aaaggtgcta tcagtgctaa agcattcatt gctgtccttc     4200

aagcaaccca gagtcatgga catgttaaaa ctttacttcc tgttttcttt gcagttcctg     4260

gtgaaagagg gctatttaga tcaagaaggt aatcctatgg ggtttgctgg acttgtatca     4320

catttgcatt atcatgaacc ttctaatctt gtttttgtca gttttcttgt aaatggactc     4380

ttccatgatc tctgtcagcc aaccaggaaa ggctcaaaac atttttctca agacgttatg     4440

gaaaagctag tattagtatt ggcacatctc tttggaagaa gatattttcc accaaagttc     4500

caagatgcac acttcgagtt ttatcaatca aaggtgttcc ttgatgatct ccctgaggat     4560

tttagtgatg ctttagatga atataacatg aaaattatgg aggactttac cactttccta     4620

cgaattgttt ccaaactggc tgatatgaat caggaatatc aactcccatt gtcaaaaatc     4680

aaattcacag gtaaagaatg tgaagactct caactcgtat ctcatttgat gagctgcaag     4740

gaaggaagag tagcaatttc accatttgtt tgtctgtctg ggaactttga tgatgatttg     4800

cttcgactag aaactccaaa ccatgttact ctaggcacaa tcggtgtcaa tcgctctcag     4860

gctccagtgc tgttgtcaca gaaatttgat aaccgaggaa ggaaaatgtc gcttaatgcc     4920

tatgcactgg atttctacaa acatggttcc ttgataggat tagtccagga taacaggatg     4980

aatgaaggag atgcttatta tttgttgaag gattttgcac tcaccattaa atctatcagt     5040

gtttccttgc gtgagctatg tgaaaatgaa gacgacaacg ttgtcttagc ctttgaacaa     5100

ctgagtacaa ctttttggga aaagttaaac aaagtctaa                            5139


<210>  264
<211>  1653
<212>  DNA
<213>  Homo sapiens;

<400>  264
atggtgccca aggcagacag cggcgccttc ctgctgctct tcctgctcgt gctcactgtc       60

accgagccgc tgcggccaga gctgcggtgc aaccctgggc agtttgcgtg tcgcagcggc      120

accatccagt gcatccccct cccctggcag tgtgacggct gggcgacttg cgaggatgag      180

agcgacgaag ccaactgtcc agaagtgacc ggggaggtgc gtcctcatca tgggaaggag      240

gctgtggatc cgcggcaggg gcgggccaga ggaggcgacc cttcgcactt ccacgcggtg      300

aacgtggcgc agcccgttcg cttcagcagt ttcctaggga agtgcccgac agggtggcac      360

cactacgaag gcacggccag ctgctaccgg gtctacctga gcggggagaa ctactgggat      420

gccgcgcaga cctgccagcg cctgaatggc tctctcgcca ccttctccac tgaccaggag      480

ctgcgctttg tcctggccca ggaatgggac cagcccgagc ggagctttgg ttggaaggac      540

cagcgcaagt tgtgggttgg ctatcagtat gttatcactg gccggaaccg ctccttggaa      600

ggtcgctggg aggtggcatt caaaggctct tcagaggtgt tcctgccccc agaccccatc      660

tttgcctcgg ccatgtctga gaacgacaac gtgttctgtg cccagcttca gtgcttccat      720

ttccccaccc tgcggcacca cgacctccac agctggcacg ccgagagctg ctacgagaag      780

tcttcatttc tgtgtaaaag aagtcaaaca tgtgttgaca tcaaggacaa cgtggtggat      840

gaagggttct acttcacccc taagggggac gacccatgcc tgagctgcac ctgccatgga      900

ggggagcctg agatgtgtgt ggctgctctc tgtgagaggc cccagggctg ccaacagtac      960

cgcaaggacc ccaaagagtg ctgcaagttc atgtgtctgg acccagatgg caacagtctg     1020

tttgactcca tggccagcgg gatgcgcctg gtcgtcagct gcatctcctc cttcctcatc     1080

ctgtcactgc tgctcttcat ggtccaccgg ctgcgccagc ggcgccggga gcgcatcgag     1140

tccctgattg gagcaaactt gcaccacttc aacctcggcc gcaggatccc tggctttgat     1200

tacggcccag acgggtttgg cacgggcctc acgccgctgc atctttctga cgacggagag     1260

ggtgggactt tccatttcca cgaccctcca cctccctaca cggcatacaa gtacccggac     1320

atcggccagc ccgacgaccc tccgccgccc tacgaggcct ccatccaccc ggacagtgtg     1380

ttctatgacc ctgcagacga tgatgctttt gagcctgtgg aggtcagcct gccagcccct     1440

ggggatggtg ggagtgaagg tgcattactc cggcgcctgg agcagcctct gcccactgcg     1500

ggggcctctc tggcagacct ggaagactct gccgacagca gcagcgccct gctcgtgccc     1560

cctgaccctg cccagagcgg gagcacccca gctgcagagg cactgccagg gggtggccgc     1620

cacagccgca gctccctcaa tactgtggtg tag                                  1653


<210>  265
<211>  2208
<212>  DNA
<213>  Homo sapiens;

<400>  265
atggccaagg agaggggcct aataagcccc agtgattttg cccagctgca aaaatacatg       60

gaatactcca ccaaaaaggt cagtgatgtc ctaaagctct tcgaggatgg cgagatggct      120

aaatatgtcc aaggagatgc cattgggtac gagggattcc agcaattcct gaaaatctat      180

ctcgaagtgg ataatgttcc cagacaccta agcctggcac tgtttcaatc ctttgagact      240

ggtcactgct taaatgagac aaatgtgaca aaagatgtgg tgtgtctcaa tgatgtttcc      300

tgctactttt cccttctgga gggtggtcgg ccagaagaca agttagaatt caccttcaag      360

ctgtacgaca cggacagaaa tgggatcctg gacagctcag aagtggacaa aattatccta      420

cagatgatgc gagtggctga atacctggat tgggatgtgt ctgagctgag gccgattctt      480

caggagatga tgaaagagat tgactatgat ggcagtggct ctgtctctca agctgagtgg      540

gtccgggctg gggccaccac cgtgccactg ctagtgctgc tgggtctgga gatgactctg      600

aaggacgacg gacagcacat gtggaggccc aagaggttcc ccagaccagt ctactgcaat      660

ctgtgcgagt caagcattgg tcttggcaaa cagggactga gctgtaacct ctgtaagtac      720

actgttcacg accagtgtgc catgaaagcc ctgccttgtg aagtcagcac ctatgccaag      780

tctcggaagg acattggtgt ccaatcacat gtgtgggtgc gaggaggctg tgagtccggg      840

cgctgcgacc gctgtcagaa aaagatccgg atctaccaca gtctgaccgg gctgcattgt      900

gtatggtgcc acctagagat ccacgatgac tgcctgcaag cggtgggcca tgagtgtgac      960

tgtgggctgc tccgggatca catcctgcct ccatcttcca tctatcccag tgtcctggcc     1020

tctggaccgg atcgtaaaaa tagcaaaaca agccagaaga ccatggatga tttaaatttg     1080

agcacctctg aggctctgcg gattgaccct gttcctaaca cccacccact tctcgtcttt     1140

gtcaatccta agagtggcgg gaagcagggg caaagggtgc tctggaagtt ccagtatata     1200

ttaaaccctc gacaggtgtt caacctccta aaggatggtc ctgagatagg gctccgatta     1260

ttcaaggatg ttcctgatag ccggattttg gtgtgtggtg gagacggcac agtaggctgg     1320

attctagaga ccattgacaa agctaacttg ccagttttgc ctcctgttgc tgtgttgccc     1380

ctgggtactg gaaatgatct ggctcgatgc ctaagatggg gaggaggtta tgaaggacag     1440

aatctggcaa agatcctcaa ggatttagag atgagtaaag tggtacatat ggatcgatgg     1500

tctgtggagg tgatacctca acaaactgaa gaaaaaagtg acccagtccc ctttcaaatc     1560

atcaataact acttctctat tggcgtggat gcctctattg ctcatcgatt ccacatcatg     1620

cgagagaaat atccggagaa gttcaacagc agaatgaaga acaagctatg gtacttcgaa     1680

tttgccacat ctgaatccat cttctcaaca tgcaaaaagc tggaggagtc tttgacagtt     1740

gagatctgtg ggaaaccgct ggatctgagc aacctgtccc tagaaggcat cgcagtgcta     1800

aacatcccta gcatgcatgg tggctccaac ctctggggtg ataccaggag accccatggg     1860

gatatctatg ggatcaacca ggccttaggt gctacagcta aagtcatcac cgaccctgat     1920

atcctgaaaa cctgtgtacc agacctaagt gacaagagac tggaagtggt tgggctggag     1980

ggtgcaattg agatgggcca aatctatacc aagctcaaga atgctggacg tcggctggcc     2040

aagtgctctg agatcacctt ccacaccaca aaaacccttc ccatgcaaat tgacggagaa     2100

ccctggatgc agacgccctg tacaatcaag atcacccaca agaaccagat gcccatgctc     2160

atgggcccac ccccccgctc caccaatttc tttggcttct tgagctaa                  2208


<210>  266
<211>  2037
<212>  DNA
<213>  Homo sapiens;

<400>  266
atggagcttc ggtcctacca atgggaggtg atcatgcctg ccctggaggg caagaatatc       60

atcatctggc tgcccacggg tgccgggaag acccgggcgg ctgcttatgt ggccaagcgg      120

cacctagaga ctgtggatgg agccaaggtg gttgtattgg tcaacagggt gcacctggtg      180

acccagcatg gtgaagagtt caggcgcatg ctggatggac gctggaccgt gacaaccctg      240

agtggggaca tgggaccacg tgctggcttt ggccacctgg cccggtgcca tgacctgctc      300

atctgcacag cagagcttct gcagatggca ctgaccagcc ccgaggagga ggagcacgtg      360

gagctcactg tcttctccct gatcgtggtg gatgagtgcc accacacgca caaggacacc      420

gtctacaacg tcatcatgag ccagtaccta gaacttaaac tccagagggc acagccgcta      480

ccccaggtgc tgggtctcac agcctcccca ggcactggcg gggcctccaa actcgatggg      540

gccatcaacc acgtcctgca gctctgtgcc aacttggaca cgtggtgcat catgtcaccc      600

cagaactgct gcccccagct gcaggagcac agccaacagc cttgcaaaca gtacaacctc      660

tgccacaggc gcagccagga tccgtttggg gacttgctga agaagctcat ggaccaaatc      720

catgaccacc tggagatgcc tgagttgagc cggaaatttg ggacgcaaat gtatgagcag      780

caggtggtga agctgagtga ggctgcggct ttggctgggc ttcaggagca acgggtgtat      840

gcgcttcacc tgaggcgcta caatgacgcg ctgctcatcc atgacaccgt ccgcgccgtg      900

gatgccttgg ctgcgctgca ggatttctat cacagggagc acgtcactaa aacccagatc      960

ctgtgtgccg agcgccggct gctggccctg ttcgatgacc gcaagaatga gctggcccac     1020

ttggcaactc atggcccaga gaatccaaaa ctggagatgc tggaaaagat cctgcaaagg     1080

cagttcagta gctctaacag ccctcggggt atcatcttca cccgcacccg ccaaagcgca     1140

cactccctcc tgctctggct ccagcagcag cagggcctgc agactgtgga catccgggcc     1200

cagctactga ttggggctgg gaacagcagc cagagcaccc acatgaccca gagggaccag     1260

caagaagtga tccagaagtt ccaagatgga accctgaacc ttctggtggc cacgagtgtg     1320

gcggaggagg ggctggacat cccacattgc aatgtggtgg tgcgttatgg gctcttgacc     1380

aatgaaatct ccatggtcca ggccaggggc cgtgcccggg ccgatcagag tgtatacgcg     1440

tttgtagcaa ctgaaggtag ccgggagctg aagcgggagc tgatcaacga ggcgctggag     1500

acgctgatgg agcaggcagt ggctgctgtg cagaaaatgg accaggccga gtaccaggcc     1560

aagatccggg atctgcagca ggcagccttg accaagcggg cggcccaggc agcccagcgg     1620

gagaaccagc ggcagcagtt cccagtggag cacgtgcagc tactctgcat caactgcatg     1680

gtggctgtgg gccatggcag cgacctgcgg aaggtggagg gcacccacca tgtcaatgtg     1740

aaccccaact tctcgaacta ctataatgtc tccagggatc ctgtggtcat caacaaagtc     1800

ttcaaggact ggaagcctgg gggtgtcatc agctgcagga actgtgggga ggtctggggt     1860

ctgcagatga tctacaagtc agtgaagctg ccagtgctca aagtccgcag catgctgctg     1920

gagacccctc aggggcggat ccaggccaaa aagtggtccc gcgtgccctt ctccgtgcct     1980

gactttgact tcctgcagca ttgtgccgag aacttgtcgg acctctccct ggactga        2037


<210>  267
<211>  1689
<212>  DNA
<213>  Homo sapiens;

<400>  267
atggacgaca aaggcgaccc gagcaatgag gaggcaccta aggccatcaa acccaccagc       60

aaagagttca ggaaaacatg gggttttcga aggaccacta tcgccaagcg agagggcgca      120

ggggacgcgg aggctgaccc actggagccg ccacccccac agcagcagct gggcctgtcc      180

ctgcggcgca gtgggaggca gcccaagcgc actgagcgcg tggagcagtt cctgaccatt      240

gcgcggcgcc gcggcaggag gagcatgcct gtctccctgg aggattctgg tgagcccacg      300

tcctgccccg ccacagacgc cgagacagcc tccgagggca gcgtggaaag cgcttctgag      360

accagaagcg gcccccagtc tgcttccaca gctgtgaagg aacgaccagc ctcttctgaa      420

aaggtgaaag gaggggatga ccacgatgac acctccgata gtgacagcga tggcctgacc      480

ttgaaagagc ttcagaatcg ccttcgcagg aagcgggaac aggagcccac tgagaggccc      540

ctgaaaggga tccagagtcg cctgcggaag aagcgccggg aggagggtcc cgccgagact      600

gtgggctccg aggccagtga cactgtggag ggcgtcctgc ccagtaagca ggagcccgag      660

aacgatcagg gggttgtgtc ccaggctggg aaagatgaca gagagagtaa gttggaggga      720

aaggcggctc aggacatcaa agatgaggag cctggagact tgggccgacc gaagcctgaa      780

tgtgagggtt acgaccccaa cgccctgtat tgcatttgcc gccagcctca caacaacagg      840

tttatgattt gctgtgaccg ctgtgaagaa tggtttcatg gcgattgtgt gggcatttct      900

gaggctcgag ggaggctttt ggaaaggaat ggggaagact atatctgccc aaactgcacc      960

attctgcaag tgcaggatga gactcattca gaaacggcag atcagcagga agctaaatgg     1020

agacctggag atgctgatgg caccgattgt acaagtatag gaacaataga gcagaagtct     1080

agcgaagacc aagggataaa gggtagaatt gagaaagctg caaatccaag tggcaagaag     1140

aaactcaaga tcttccagcc tgtgatagag gcgcctggtg cctcaaaatg tattggcccc     1200

gggtgctgtc acgtggcgca gcccgactcg gtgtactgca gtaatgactg tatcctcaaa     1260

cacgccgcag cgacaatgaa gtttctaagc tcaggtaaag aacagaagcc aaagcctaaa     1320

gaaaagatga agatgaagcc agagaagccc agtcttccga aatgcggtgc tcaggcaggt     1380

attaaaatct cttctgtgca caagagacca gctccagaaa aaaaagagac cacagtgaag     1440

aaggcagtgg tggtccctgc gcggagtgaa gcactcggga aggaagcagc ttgtgagagc     1500

agcacgccgt cgtgggcgag cgatcacaat tacaatgcag taaagccaga aaagactgct     1560

gctccctcgc cgtcactgtt gtataaatgt atgtatcacc taggggttgg cctcctggac     1620

ccctcccgtt ctttctggat agccatcccc tgggcctgtc caggactggg agttgcagct     1680

ttgtgttaa                                                             1689


<210>  268
<211>  6207
<212>  DNA
<213>  Homo sapiens;

<400>  268
atgcaggctg ataaatgcag gacaagtagt agaagtgtca aaaaggaact ggtgattgag       60

tcccccctgc aatacaagga tgcagctcag ggcgaagtgg aagcagagag cccgggccct      120

gtgccggcaa agccaaagct aattgagcca ctcgactatg aaaatgtcat cgtccagaag      180

aagactcaga tcctgaacga ctgtttacgg gagatgctgc tcttccctta cgatgacttt      240

cagacggcca tcctgagacg acagggtcga tacatatgct caacagtgcc tgcgaaggcg      300

gaagaggaag cacagagctt gtttgttaca gagtgcatca aaacctataa ctctgactgg      360

catcttgtga actataaata tgaagattac tcaggagagt ttcgacagct tccgaacaaa      420

gtggtcaagt tggataaact tccagttcat gtctatgaag ttgacgagga ggtcgacaaa      480

gatgaggatg ctgcctccct tggttcccag aagggtggga tcaccaagca tggctggctg      540

tacaaaggca acatgaacag tgccatcagc gtgaccatga ggtcatttaa gagacgattt      600

ttccacctga ttcaacttgg cgatggatcc tataatttga atttttataa agatgaaaag      660

atctccaaag aaccaaaagg atcaatattt ctggattcct gtatgggtgt cgttcagaac      720

aacaaagtca ggcgttttgc ttttgagctc aagatgcagg acaaaagtag ttatctcttg      780

gcagcagaca gtgaagtgga aatggaagaa tggatcacaa ttctaaataa gatcctccag      840

ctcaactttg aagctgcaat gcaagaaaag cgaaatggcg actctcacga agatgatgaa      900

caaagcaaat tggaaggttc tggttccggt ttagatagct acctgccgga acttgccaag      960

agtgcaagag aagcagaaat caaactgaaa agtgaaagca gagtcaaact tttttatttg     1020

gacccagatg cccagaagct tgacttctca tcagctgagc cagaagtgaa gtcatttgaa     1080

gagaagtttg gaaaaaggat ccttgtcaag tgcaatgatt tatctttcaa tttgcaatgc     1140

tgtgttgccg aaaatgaaga aggacccact acaaatgttg aacctttctt tgttactcta     1200

tccctgtttg acataaaata caaccggaag atttctgccg atttccacgt agacctgaac     1260

catttctcag tgaggcaaat gctcgccacc acgtccccgg cgctgatgaa tggcagtggg     1320

cagagcccat ctgtcctcaa gggcatcctt catgaagccg ccatgcagta tccgaagcag     1380

ggaatatttt cagtcacttg tcctcatcca gatatatttc ttgtggccag aattgaaaaa     1440

gtccttcagg ggagcatcac acattgcgct gagccatata tgaaaagttc agactcttct     1500

aaggtggccc agaaggtgct gaagaatgcc aagcaggcat gccaaagact aggacagtat     1560

agaatgccat ttgcttgggc agcaaggaca ttgtttaagg atgcatctgg aaatcttgac     1620

aaaaatgcca gattttctgc catctacagg caagacagca ataagctatc caatgatgac     1680

atgctcaagt tacttgcaga ctttcggaaa cctgagaaga tggctaagct cccagtgatt     1740

ttaggcaatc tagacattac aattgataat gtttcctcag acttccctaa ttatgttaat     1800

tcatcataca ttcccacaaa acaatttgaa acctgcagta aaactcccat cacgtttgaa     1860

gtggaggaat ttgtgccctg cataccaaaa cacactcagc cttacaccat ctacaccaat     1920

cacctttacg tttatcctaa gtacttgaaa tacgacagtc agaagtcttt tgccaaggct     1980

agaaatattg cgatttgcat tgaattcaaa gattcagatg aggaagactc tcagcccctt     2040

aagtgcattt atggcagacc tggtgggcca gttttcacaa gaagcgcctt tgctgcagtt     2100

ttacaccatc accaaaaccc agaattttat gatgagatta aaatagagtt gcccactcag     2160

ctgcatgaaa agcaccacct gttgctcaca ttcttccatg tcagctgtga caactcaagt     2220

aaaggaagca cgaagaagag ggatgtcgtt gaaacccaag ttggctactc ctggcttccc     2280

ctcctgaaag acggaagggt ggtgacaagc gagcagcaca tcccggtctc ggcgaacctt     2340

ccttcgggct atcttggcta ccaggagctt gggatgggca ggcattatgg tccggaaatt     2400

aaatgggtag atggaggcaa gccactgctg aaaatttcca ctcatctggt ttctacagtg     2460

tatactcagg atcagcattt acataatttt ttccagtact gtcagaaaac cgaatctgga     2520

gcccaagcct taggaaacga acttgtaaag taccttaaga gtctgcatgc gatggaaggc     2580

cacgtgatga tcgccttctt gcccactatc ctaaaccagc tgttccgagt cctcaccaga     2640

gccacacagg aagaagtcgc ggttaacgtg actcgggtca ttattcatgt ggttgcccag     2700

tgccatgagg aaggattgga gagccacttg aggtcatatg ttaagtacgc gtataaggct     2760

gagccatatg ttgcctctga atacaagaca gtgcatgaag aactgaccaa atccatgacc     2820

acgattctca agccttctgc cgatttcctc accagcaaca aactactgaa gtactcatgg     2880

tttttctttg atgtactgat caaatctatg gctcagcatt tgatagagaa ctccaaagtt     2940

aagttgctgc gaaaccagag atttcctgca tcctatcatc atgcagtgga aaccgttgta     3000

aatatgctga tgccacacat cactcagaag tttcgagata atccagaggc atctaagaac     3060

gcgaatcata gccttgctgt cttcatcaag agatgtttca ccttcatgga caggggcttt     3120

gtcttcaagc agatcaacaa ctacattagc tgttttgctc ctggagaccc aaagaccctc     3180

tttgaataca agtttgaatt tctccgtgta gtgtgcaacc atgaacatta tattccgttg     3240

aacttaccaa tgccatttgg aaaaggcagg attcaaagat accaagacct ccagcttgac     3300

tactcattaa cagatgagtt ctgcagaaac cacttcttgg tgggactgtt actgagggag     3360

gtggggacag ccctccagga gttccgggag gtccgtctga tcgccatcag tgtgctcaag     3420

aacctgctga taaagcattc ttttgatgac agatatgctt caaggagcca tcaggcaagg     3480

atagccaccc tctacctgcc tctgtttggt ctgctgattg aaaacgtcca gcggatcaat     3540

gtgagggatg tgtcaccctt ccctgtgaac gcgggcatga ctgtgaagga tgaatccctg     3600

gctctaccag ctgtgaatcc gctggtgacg ccgcagaagg gaagcaccct ggacaacagc     3660

ctgcacaagg acctgctggg cgccatctcc ggcattgctt ctccatatac aacctcaact     3720

ccaaacatca acagtgtgag aaatgctgat tcgagaggat ctctcataag cacagattcg     3780

ggtaacagcc ttccagaaag gaatagtgag aagagcaatt ccctggataa gcaccaacaa     3840

agtagcacat tgggaaattc cgtggttcgc tgtgataaac ttgaccagtc tgagattaag     3900

agcctactga tgtgtttcct ctacatctta aagagcatgt ctgatgatgc tttgtttaca     3960

tattggaaca aggcttcaac atctgaactt atggattttt ttacaatatc tgaagtctgc     4020

ctgcaccagt tccagtacat ggggaagcga tacatagcca gaacaggaat gatgcatgcc     4080

agattgcagc agctgggcag cctggataac tctctcactt ttaaccacag ctatggccac     4140

tcggacgcag atgttctgca ccagtcatta cttgaagcca acattgctac tgaggtttgc     4200

ctgacagctc tggacacgct ttctctattt acattggcgt ttaagaacca gctcctggcc     4260

gaccatggac ataatcctct catgaaaaaa gtttttgatg tctacctgtg ttttcttcaa     4320

aaacatcagt ctgaaacggc tttaaaaaat gtcttcactg ccttaaggtc cttaatttat     4380

aagtttccct caacattcta tgaagggaga gcggacatgt gtgcggctct gtgttacgag     4440

attctcaagt gctgtaactc caagctgagc tccatcagga cggaggcctc ccagctgctc     4500

tacttcctga tgaggaacaa ctttgattac actggaaaga agtcctttgt ccggacacat     4560

ttgcaagtca tcatatctgt cagccagctg atagcagacg ttgttggcat tgggggaacc     4620

agattccagc agtccctgtc catcatcaac aactgtgcca acagtgaccg gcttattaag     4680

cacaccagct tctcctctga tgtgaaggac ttaaccaaaa ggatacgcac ggtgctaatg     4740

gccaccgccc agatgaagga gcatgagaac gacccagaga tgctggtgga cctccagtac     4800

agcctggcca aatcctatgc cagcacgccc gagctcagga agacgtggct cgacagcatg     4860

gccaggatcc atgtcaaaaa tggcgatctc tcagaggcag caatgtgcta tgtccacgta     4920

acagccctag tggcagaata tctcacacgg aaagaagcag tccagtggga gccgcccctt     4980

ctcccccaca gccatagcgc ctgcctgagg aggagccggg gaggcgtgtt tagacaagga     5040

tgcaccgcct tcagggtcat taccccaaac atcgacgagg aggcctccat gatggaagac     5100

gtggggatgc aggatgtcca tttcaacgag gatgtgctga tggagctcct tgagcagtgc     5160

gcagatggac tctggaaagc cgagcgctac gagctcatcg ccgacatcta caaacttatc     5220

atccccattt atgagaagcg gagggatttt gagaggctgg cccatctgta tgacacgctg     5280

caccgggcct acagcaaagt gaccgaggtc atgcactcgg gccgcaggct tctggggacc     5340

tacttccggg tagccttctt cgggcaggca gcgcaatacc agtttacaga cagtgaaaca     5400

gatgtggagg gattctttga agatgaagat ggaaaggagt atatttacaa ggaacccaaa     5460

ctcacaccgc tgtcggaaat ttctcagaga ctccttaaac tgtactcgga taaatttggt     5520

tctgaaaatg tcaaaatgat acaggattct ggcaaggtca accctaagga tctggattct     5580

aagtatgcat acatccaggt gactcacgtc atccccttct ttgacgaaaa agagttgcaa     5640

gaaaggaaaa cagagtttga gagatcccac aacatccgcc gcttcatgtt tgagatgcca     5700

tttacgcaga ccgggaagag gcagggcggg gtggaagagc agtgcaaacg gcgcaccatc     5760

ctgacagcca tacactgctt cccttatgtg aagaagcgca tccctgtcat gtaccagcac     5820

cacactgacc tgaaccccat cgaggtggcc attgacgaga tgagtaagaa ggtggcggag     5880

ctccggcagc tgtgctcctc ggccgaggtg gacatgatca aactgcagct caaactccag     5940

ggcagcgtga gtgttcaggt caatgctggc ccactagcat atgcgcgagc tttcttagat     6000

gatacaaaca caaagcgata tcctgacaat aaagtgaagc tgcttaagga agttttcagg     6060

caatttgtgg aagcttgcgg tcaagcctta gcggtaaacg aacgtctgat taaagaagac     6120

cagctcgagt atcaggaaga aatgaaagcc aactacaggg aaatggcgaa ggagctttct     6180

gaaatcatgc atgagcagct gggatga                                         6207


<210>  269
<211>  1491
<212>  DNA
<213>  Homo sapiens;

<400>  269
atgactcggg gagccagact gcgatcagac gcgcgtgccc agctgaacca gctgtctcta       60

gacggaggga cgggaagtgg ccagaagggg aagtgtgagg agttcccgtc cagcctgtca      120

tcagtctccc caggtcttga agcggcggcc ctgctcctgg ccgtgaccat ggaccctctg      180

gagaccccta tcaaggatgg catcctctac cagcagcatg tcaagtttgg caagaagtgc      240

tggcggaagg tgtgggctct gctgtatgca ggaggcccat caggcgtggc acggctggag      300

agctgggagg tccgggatgg tggcctggga gcagcgggtg acaggtcggc agggcctggc      360

cggcgagggg agcgacgggt catccgcctg gctgactgtg tgtccgtgct gccggctgac      420

ggcgagagct gcccccggga caccggtgcc ttcctgctca ccaccaccga gcgaagccat      480

ctactggctg ctcagcaccg ccaggcctgg atgggcccca tctgccagct ggccttcccg      540

gggacagggg aggcctcctc aggatccaca gatgcccagt ctcccaagag gggcctggtc      600

cccatggagg aaaactccat ctactcctcc tggcaggaag tgggcgagtt tcccgtggtg      660

gtgcagagga ctgaggccgc cacccgctgc cagctgaagg ggccggccct gctggtgctg      720

ggcccagacg ccatccagct gagggaggcc aagggcaccc aggccctcta cagctggccc      780

taccacttcc tgcgcaagtt cggctccgac aagggcgtgt tctcctttga ggccggccgt      840

cgctgccact cgggtgaggg cctctttgcc ttcagcaccc cctgtgcccc tgacctgtgc      900

agggctgtgg ccggggccat cgcccgccag cgggagcggc tgccagagct gaccaggccc      960

cagccctgcc ccctgccacg ggccacctct ctgccctccc tggacacccc cggagagctt     1020

cgggagatgc caccaggacc tgagccaccc acgtccagga aaatgcacct ggccgagccc     1080

ggaccccaga gcctgccgct actgctaggc ccggagccca acgatctggc gtccgggctc     1140

tacgcttcag tgtgcaagcg tgccagtggg cccccaggca atgagcacct ctatgagaac     1200

ctgtgtgtgc tggaggccag ccccacgctg cacggtgggg aacctgagcc gcacgagggc     1260

cccggcagcc gcagccccac aaccagtccc atctaccaca acggccagga cttgagctgg     1320

cccggcccgg ccaacgacag taccctggag gcccagtacc ggcggctgct ggagctggat     1380

caggtggagg gcacaggccg ccctgaccct caggcaggtt tcaaggccaa gctggtgacc     1440

ctgctgagtc gtgagcggag gaagggccca gccccttgtg accggccctg a              1491


<210>  270
<211>  1461
<212>  DNA
<213>  Homo sapiens;

<400>  270
atgcagccct ccggcctcga gggtcccggc acgtttggtc ggtggcctct gctgagtctg       60

ctgctcctgc tgctgctgct ccagcctgta acctgtgcct acaccacgcc aggccccccc      120

agagccctca ccacgctggg cgcccccaga gcccacacca tgccgggcac ctacgctccc      180

tcgaccacac tcagtagtcc cagcacccag ggcctgcaag agcaggcacg ggccctgatg      240

cgggacttcc cgctcgtgga cggccacaac gacctgcccc tggtcctaag gcaggtttac      300

cagaaagggc tacaggatgt taacctgcgc aatttcagct acggccagac cagcctggac      360

aggcttagag atggcctcgt gggcgcccag ttctggtcag cctatgtgcc atgccagacc      420

caggaccggg atgccctgcg cctcaccctg gagcagattg acctcatacg ccgcatgtgt      480

gcctcctatt ctgagctgga gcttgtgacc tcggctaaag ctctgaacga cactcagaaa      540

ttggcctgcc tcatcggtgt agagggtggc cactcgctgg acaatagcct ctccatctta      600

cgtaccttct acatgctggg agtgcgctac ctgacgctca cccacacctg caacacaccc      660

tgggcagaga gctccgctaa gggcgtccac tccttctaca acaacatcag cgggctgact      720

gactttggtg agaaggtggt ggcagaaatg aaccgcctgg gcatgatggt agacttatcc      780

catgtctcag atgctgtggc acggcgggcc ctggaagtgt cacaggcacc tgtgatcttc      840

tcccactcgg ctgcccgggg tgtgtgcaac agtgctcgga atgttcctga tgacatcctg      900

cagcttctga agaagaacgg tggcgtcgtg atggtgtctt tgtccatggg agtaatacag      960

tgcaacccat cagccaatgt gtccactgtg gcagatcact tcgaccacat caaggctgtc     1020

attggatcca agttcatcgg gattggtgga gattatgatg gggccggcaa attccctcag     1080

gggctggaag acgtgtccac atacccggtc ctgatagagg agttgctgag tcgtggctgg     1140

agtgaggaag agcttcaggg tgtccttcgt ggaaacctgc tgcgggtctt cagacaagtg     1200

gaaaaggtac aggaagaaaa caaatggcaa agccccttgg aggacaagtt cccggatgag     1260

cagctgagca gttcctgcca ctccgacctc tcacgtctgc gtcagagaca gagtctgact     1320

tcaggccagg aactcactga gattcccata cactggacag ccaagttacc agccaagtgg     1380

tcagtctcag agtcctcccc ccacatggcc ccagtccttg cagttgtggc caccttccca     1440

gtccttattc tgtggctctg a                                               1461


<210>  271
<211>  1176
<212>  DNA
<213>  Homo sapiens;

<400>  271
atggcggctg tggtggagaa tgtagtgaag ctccttgggg agcagtacta caaagatgcc       60

atggagcagt gccacaatta caatgctcgc ctctgtgctg agcgcagcgt gcgcctgcct      120

ttcttggact cacagaccgg agtagcccag agcaattgtt acatctggat ggaaaagcga      180

caccggggtc caggattggc ctccggacag ctgtactcct accctgcccg gcgctggcgg      240

aaaaagcggc gagcccatcc ccctgaggat ccacgacttt ccttcccatc tattaagcca      300

gacacagacc agaccctgaa gaaggagggg ctgatctctc aggatggcag tagtttagag      360

gctctgttgc gcactgaccc cctggagaag cgaggtgccc cggatccccg agttgatgat      420

gacagcctgg gcgagtttcc tgtgaccaac agtcgagcgc gaaagcggat cctagaacca      480

gatgacttcc tggatgacct cgatgatgaa gactatgaag aagatactcc caagcgtcgg      540

ggaaagggga aatccaaggg taagggtgtg ggcagtgccc gtaagaagct ggatgcttcc      600

atcctggagg accgggataa gccctatgcc tgtgacattt gtggaaaacg ttacaagaac      660

cgaccaggcc tcagttacca ctatgcccac tcccacttgg ctgaggagga gggcgaggac      720

aaggaagact ctcaaccacc cactcctgtt tcccagaggt ctgaggagca gaaatccaaa      780

aagggtcctg atggattggc cttgcccaac aactactgtg acttctgcct gggggactca      840

aagattaaca agaagacggg acaacccgag gagctggtgt cctgttctga ctgtggccgc      900

tcagggcatc catcttgcct ccaatttacc cccgtgatga tggcggcagt gaagacatac      960

cgctggcagt gcatcgagtg caaatgttgc aatatctgcg gcacctccga gaatgacgac     1020

cagttgctct tctgtgatga ctgcgatcgt ggctaccaca tgtactgtct caccccgtcc     1080

atgtctgagc cccctgaagg aagttggagc tgccacctgt gtctggacct gttgaaagag     1140

aaagcttcca tctaccagaa ccagaactcc tcttga                               1176


<210>  272
<211>  1656
<212>  DNA
<213>  Homo sapiens;

<400>  272
atggctggtg atctttcagc aggtttcttc atggaggaac ttaatacata ccgtcagaag       60

cagggagtag tacttaaata tcaagaactg cctaattcag gacctccaca tgataggagg      120

tttacatttc aagttataat agatggaaga gaatttccag aaggtgaagg tagatcaaag      180

aaggaagcaa aaaatgccgc agccaaatta gctgttgaga tacttaataa ggaaaagaag      240

gcagttagtc ctttattatt gacaacaacg aattcttcag aaggattatc catggggaat      300

tacataggcc ttatcaatag aattgcccag aagaaaagac taactgtaaa ttatgaacag      360

tgtgcatcgg gggtgcatgg gccagaagga tttcattata aatgcaaaat gggacagaaa      420

gaatatagta ttggtacagg ttctactaaa caggaagcaa aacaattggc cgctaaactt      480

gcatatcttc agatattatc agaagaaacc tcagtgaaat ctgactacct gtcctctggt      540

tcttttgcta ctacgtgtga gtcccaaagc aactctttag tgaccagcac actcgcttct      600

gaatcatcat ctgaaggtga cttctcagca gatacatcag agataaattc taacagtgac      660

agtttaaaca gttcttcgtt gcttatgaat ggtctcagaa ataatcaaag gaaggcaaaa      720

agatctttgg cacccagatt tgaccttcct gacatgaaag aaacaaagta tactgtggac      780

aagaggtttg gcatggattt taaagaaata gaattaattg gctcaggtgg atttggccaa      840

gttttcaaag caaaacacag aattgacgga aagacttacg ttattaaacg tgttaaatat      900

aataacgaga aggcggagcg tgaagtaaaa gcattggcaa aacttgatca tgtaaatatt      960

gttcactaca atggctgttg ggatggattt gattatgatc ctgagaccag tgatgattct     1020

cttgagagca gtgattatga tcctgagaac agcaaaaata gttcaaggtc aaagactaag     1080

tgccttttca tccaaatgga attctgtgat aaagggacct tggaacaatg gattgaaaaa     1140

agaagaggcg agaaactaga caaagttttg gctttggaac tctttgaaca aataacaaaa     1200

ggggtggatt atatacattc aaaaaaatta attcatagag atcttaagcc aagtaatata     1260

ttcttagtag atacaaaaca agtaaagatt ggagactttg gacttgtaac atctctgaaa     1320

aatgatggaa agcgaacaag gagtaaggga actttgcgat acatgagccc agaacagatt     1380

tcttcgcaag actatggaaa ggaagtggac ctctacgctt tggggctaat tcttgctgaa     1440

cttcttcatg tatgtgacac tgcttttgaa acatcaaagt ttttcacaga cctacgggat     1500

ggcatcatct cagatatatt tgataaaaaa gaaaaaactc ttctacagaa attactctca     1560

aagaaacctg aggatcgacc taacacatct gaaatactaa ggaccttgac tgtgtggaag     1620

aaaagcccag agaaaaatga acgacacaca tgttag                               1656


<210>  273
<211>  1059
<212>  DNA
<213>  Homo sapiens;

<400>  273
atggcgtccc gcaaggaagg taccggctct actgccacct cttccagctc caccgccggc       60

gcagcaggga aaggcaaagg caaaggcggc tcgggagatt cagccgtgaa gcaagtgcag      120

atagatggcc ttgtggtatt aaagataatc aaacattatc aagaagaagg acaaggaact      180

gaagttgttc aaggagtgct tttgggtctg gttgtagaag atcggcttga aattaccaac      240

tgctttcctt tccctcagca cacagaggat gatgctgact ttgatgaagt ccaatatcag      300

atggaaatga tgcggagcct tcgccatgta aacattgatc atcttcacgt gggctggtat      360

cagtccacat actatggctc attcgttacc cgggcactcc tggactctca gtttagttac      420

cagcatgcca ttgaagaatc tgtcgttctc atttatgatc ccataaaaac tgcccaagga      480

tctctctcac taaaggcata cagactgact cctaaactga tggaagtttg taaagaaaag      540

gatttttccc ctgaagcatt gaaaaaagca aatatcacct ttgagtacat gtttgaagaa      600

gtgccgattg taattaaaaa ttcacatctg atcaatgtcc taatgtggga acttgaaaag      660

aagtcagctg ttgcagataa acatgaattg ctcagccttg ccagcagcaa tcatttgggg      720

aagaatctac agttgctgat ggacagagtg gatgaaatga gccaagatat agttaaatac      780

aacacataca tgaggaatac tagtaaacaa cagcagcaga aacatcagta tcagcagcgt      840

cgccagcagg agaatatgca gcgccagagc cgaggagaac ccccgctccc tgaggaggac      900

ctgtccaaac tcttcaaacc accacagccg cctgccagga tggactcgct gctcattgca      960

ggccagataa acacttactg ccagaacatc aaggagttca ctgcccaaaa cttaggcaag     1020

ctcttcatgg cccaggctct tcaagaatac aacaactaa                            1059


<210>  274
<211>  2472
<212>  DNA
<213>  Homo sapiens;

<400>  274
atgggaggcc gcgtctttct cgtctttctc gcattctgtg tctggctgac tctgccggga       60

gctgaaaccc aggactccag gggctgtgcc cggtggtgcc ctcaggactc ctcgtgtgtc      120

aatgccaccg cctgtcgctg caatccaggg ttcagctctt tttctgagat catcaccacc      180

cccatggaga cttgtgacga catcaacgag tgtgcaacac tgtcgaaagt gtcatgcgga      240

aaattctcgg actgctggaa cacagagggg agctacgact gcgtgtgcag cccaggatat      300

gagcctgttt ctggggcaaa aacattcaag aatgagagcg agaacacgtg tcaagatgtg      360

gacgaatgtc agcagaaccc aaggctctgt aaaagctacg gcacctgcgt caacaccctc      420

ggcagctaca cgtgccagtg cctgcctggc ttcaagctca aacctgagga cccgaagctc      480

tgcacagatg tgaatgaatg cacctccgga caaaacccat gccacagctc cacccactgc      540

ctcaacaacg tgggcagcta tcagtgccgc tgccgcccgg gctggcaacc gattccgggg      600

tcccccaatg gcccaaacaa taccgtctgt gaagatgtgg acgagtgcag ctccgggcag      660

catcagtgtg acagctccac cgtctgcttc aacaccgtgg gttcatacag ctgccgctgc      720

cgcccaggct ggaagcccag acacggaatc ccgaataacc aaaaggacac tgtctgtgaa      780

gatatgactt tctccacctg gaccccgccc cctggagtcc acagccagac gctttcccga      840

ttcttcgaca aagtccagga cctgggcaga gactacaagc caggcttggc caataacacc      900

atccagagca tcttacaggc gctggatgag ctgctggagg cccctgggga cctggagacc      960

ctgccccgct tacagcagca ctgtgtggcc agtcacctgc tggatggcct agaggatgtc     1020

ctcagaggcc tgagcaagaa cctttccaat gggctgttga acttcagtta tcctgcaggc     1080

acagaattgt ccctggaggt gcagaagcaa gtagacagga gtgtcacctt gagacagaat     1140

caggcagtga tgcagctcga ctggaatcag gcacagaaat ctggtgaccc aggcccttct     1200

gtggtgggcc ttgtctccat tccagggatg ggcaagttgc tggctgaggc ccctctggtc     1260

ctggaacctg agaagcagat gcttctgcat gagacacacc agggcttgct gcaggacggc     1320

tcccccatcc tgctctcaga tgtgatctct gcctttctga gcaacaacga cacccaaaac     1380

ctcagctccc cagttacctt caccttctcc caccgttcag tgatcccgag acagaaggtg     1440

ctctgtgtct tctgggagca tggccagaat ggatgtggtc actgggccac cacaggctgc     1500

agcacaatag gcaccagaga caccagcacc atctgccgtt gcacccacct gagcagcttt     1560

gccgtcctca tggcccacta cgatgtgcag gaggaggatc ccgtgctgac tgtcatcacc     1620

tacatggggc tgagcgtctc tctgctgtgc ctcctcctgg cggccctcac ttttctcctg     1680

tgtaaagcca tccagaacac cagcacctca ctgcatctgc agctctcgct ctgcctcttc     1740

ctggcccacc tcctcttcct cgtggcaatt gatcaaaccg gacacaaggt gctgtgctcc     1800

atcatcgccg gtaccttgca ctatctctac ctggccacct tgacctggat gctgctggag     1860

gccctgtacc tcttcctcac tgcacggaac ctgacggtgg tcaactactc aagcatcaac     1920

agattcatga agaagctcat gttccctgtg ggctacggag tcccagctgt gacagtggcc     1980

atttctgcag cctccaggcc tcacctttat ggaacacctt cccgctgctg gctccaacca     2040

gaaaagggat ttatatgggg cttccttgga cctgtctgcg ccatcttctc tgtgaattta     2100

gttctctttc tggtgactct ctggattttg aaaaacagac tctcctccct caatagtgaa     2160

gtgtccaccc tccggaacac aaggatgctg gcatttaaag cgacagctca gctgttcatc     2220

ctgggctgca cgtggtgtct gggcatcttg caggtgggtc cggctgcccg ggtcatggcc     2280

tacctcttca ccatcatcaa cagcctgcag ggtgtcttca tcttcctggt gtactgcctc     2340

ctcagccagc aggtccggga gcaatatggg aaatggtcca aagggatcag gaaattgaaa     2400

actgagtctg agatgcacac actctccagc agtgctaagg ctgacacctc caaacccagc     2460

acggttaact ag                                                         2472


<210>  275
<211>  4116
<212>  DNA
<213>  Homo sapiens;

<400>  275
atgactacaa aacgaagttt gtttgtgcgg ttggtaccat gtcgctgtct acgaggggaa       60

gaggagactg tcactactct tgattattct cattgcagct tagaacaagt tccgaaagag      120

atttttactt ttgaaaaaac cttggaggaa ctctatttag atgctaatca gattgaagag      180

cttccaaagc aactttttaa ctgtcagtct ttacacaaac tgagtttgcc agacaatgat      240

ttaacaacgt taccagcatc cattgcaaac cttattaatc tcagggaact ggatgtcagc      300

aagaatggaa tacaggagtt tccagaaaat ataaaaaatt gtaaagtttt gacaattgtg      360

gaggccagtg taaaccctat ttccaagctc cctgatggat tttctcagct gttaaaccta      420

acccagttgt atctgaatga tgcttttctt gagttcttgc cagcaaattt tggcagatta      480

actaaactcc aaatattaga gcttagagaa aaccagttaa aaatgttgcc taaaactatg      540

aatagactga cccagctgga aagactggat ttgggaagta acgaattcac ggaagtgcct      600

gaagtacttg agcaactaag tggattgaaa gagttttgga tggatgctaa tagactgact      660

tttattccag ggtttattgg tagtttgaaa cagctcacat atttggatgt ttctaaaaat      720

aatattgaaa tggttgaaga aggaatttca acatgtgaaa accttcaaga cctcctatta      780

tcaagcaatt cacttcagca gcttcctgag actattggtt cgttgaagaa tataacaacg      840

cttaaaatag atgaaaacca gttaatgtat ctgccagact ctataggagg gttaatatca      900

gtagaagaac tggattgtag tttcaatgaa gttgaagctt tgccttcatc tattgggcag      960

cttactaact taagaacttt tgctgctgat cataattact tacagcagtt gcccccagag     1020

attggaagct ggaaaaatat aactgtgctg tttctccatt ccaataaact tgagacactt     1080

ccagaggaaa tgggtgatat gcaaaaatta aaagtcatta atttaagtga taatagatta     1140

aagaatttac cctttagctt tacaaagcta cagcaattga cagctatgtg gctctcagat     1200

aatcagtcca aacccctgat acctcttcaa aaagaaactg attcagagac ccagaaaatg     1260

gtgcttacca actacatgtt ccctcaacag ccaaggactg aggatgttat gtttatatca     1320

gataatgaaa gttttaaccc ttcattgtgg gaggaacaga ggaaacagcg ggctcaagtt     1380

gcatttgaat gtgatgaaga caaagatgaa agggaggcac ctcccaggga gggaaattta     1440

aaaagatatc caacaccata cccagatgag cttaagaata tggtcaaaac tgttcaaacc     1500

attgtacata gattaaaaga tgaagagacc aatgaagact caggaagaga tttgaaacca     1560

catgaagatc aacaagatat aaataaagat gtgggtgtga agacctcaga aagtactact     1620

acagtaaaaa gcaaagttga tgaaagagaa aaatatatga taggaaactc tgtacagaag     1680

atcagtgaac ctgaagctga gattagtcct gggagtttac cagtgactgc aaatatgaaa     1740

gcctctgaga acttgaagca tattgttaac catgatgatg tttttgagga atctgaagaa     1800

ctttcttctg atgaagagat gaaaatggcg gagatgcgac caccattaat tgaaacctct     1860

attaaccagc caaaagtcgt agcacttagt aataacaaaa aagatgatac aaaggaaaca     1920

gattctttat cagatgaagt tacacacaat agcaatcaga ataacagcaa ttgttcttct     1980

ccatctcgga tgtctgattc agtttctctt aatactgata gtagtcaaga cacctcactc     2040

tgctctccag tgaaacaaac tcatattgat attaattcca aaatcaggca agaagatgaa     2100

aattttaaca gccttttaca aaatggagat attttaaaca gttcaacaga ggaaaagttc     2160

aaagctcatg ataaaaaaga ttttaactta cctgaatatg atttgaatgt tgaagagcga     2220

ttagttctaa ttgagaaaag tgttgactca acagccacag ctgatgacac tcacaaatta     2280

gatcatatca atatgaatct taataaactt ataactaatg atacatttca accagagatc     2340

atggaaagat caaaaacaca ggatattgtg cttggaacaa gctttttaag cattaattct     2400

aaagaggaaa ctgagcactt ggaaaatgga aacaagtatc ctaatttgga atccgtaaat     2460

aaggtaaatg gacattctga ggaaacttcc cagtctccta ataggactga accacatgac     2520

agtgattgtt ctgttgactt aggtatttcc aaaagcactg aagatctctc ccctcagaaa     2580

agtggtccag ttggatctgt tgtgaaatct catagcataa ctaatatgga gattggaggg     2640

ctaaaaatct atgatattct tagtgataat ggacctcagc agccaagtac aaccgttaaa     2700

atcacatctg ctgttgatgg aaaaaatata gtcaggagca agtctgccac actgttgtat     2760

gatcaaccat tgcaggtatt tactggttct tcctcatctt ctgatttaat atcaggaaca     2820

aaggcaattt tcaagtttga ttcaaatcat aatcccgaag agccaaatat aataagaggc     2880

cccacaagtg gcccacaatc tgcacctcaa atatatggtc ctccacagta taatatccaa     2940

tacagtagca gtgctgcagt caaagacact ttgtggcact ccaaacaaaa tccccaaata     3000

gaccatgcca gttttcctcc tcagctcctt cctagatcag agagcacaga aaatcaaagt     3060

tatgctaaac attctgccaa tatgaatttc tctaatcata acaatgttcg agctaatact     3120

gcataccatt tacatcagag acttggccca gcaagacatg gggaaatgtg ggccatctca     3180

ccaaacgacc gacttattcc tgcagtaact cgaagtacaa tccagcgaca aagtagtgtg     3240

tcctccacag cctctgtaaa tcttggtgat ccaggctcta caaggcgggc tcagattcct     3300

gaaggagatt atttatcata cagagagttc cactcagcgg gaagaactcc tccaatgatg     3360

ccaggatcac agagacccct ttctgcacga acatacagca tagatggtcc aaatgcatca     3420

agacctcaga gtgctcgacc ctctattaat gaaataccag agagaactat gtcagttagt     3480

gatttcaatt attcacggac tagtccttca aaaagaccaa atgcaagggt tggttctgag     3540

cattctttat tagatcctcc aggaaaaagt aaagttcctc gtgactggag agaacaagta     3600

cttcgacata ttgaagccaa aaagttagaa aagatgcctt tgagtaatgg acagatgggc     3660

cagcctctca ggcctcaggc aaattatagt caaatacatc acccccctca ggcatctgtg     3720

gcaaggcatc cctctagaga acaactaatt gattacttga tgctgaaagt ggcccaccag     3780

cctccatata cacagcccca ttgttctcct agacaaggcc atgaactggc aaaacaagag     3840

attcgagtga gggttgaaaa ggatccagaa cttggattta gcatatcagg tggtgtcggg     3900

ggtagaggaa acccattcag acctgatgat gatggtatat ttgtaacaag ggtacaacct     3960

gaaggaccag catcaaaatt actgcagcca ggtgataaaa ttattcaggc taatggctac     4020

agttttataa atattgaaca tggacaagca gtgtccttgc taaaaacttt ccagaataca     4080

gttgaactca tcattgtacg agaagtttcc tcataa                               4116


<210>  276
<211>  1410
<212>  DNA
<213>  Homo sapiens;

<400>  276
atgaatgatt tcggaatcaa gaatatggac caggtagccc ctgtggctaa cagttacaga       60

gggacactca agcgccagcc agcctttgac acctttgatg ggtccctgtt tgctgttttt      120

ccttctctaa atgaagagca aacactgcaa gaagtgccaa caggcttgga ttccatttct      180

catgactccg ccaactgtga attgcctttg ttaaccccgt gcagcaaggc tgtgatgagt      240

caagccttaa aagctacctt cagtggcttc aaaaaggaac agcggcgcct gggcattcca      300

aagaacccct ggctgtggag tgagcaacag gtatgccagt ggcttctctg ggccaccaat      360

gagttcagtc tggtgaacgt gaatctgcag aggttcggca tgaatggcca gatgctgtgt      420

aaccttggca aggaacgctt tctggagctg gcacctgact ttgtgggtga cattctctgg      480

gaacatctgg agcaaatgat caaagaaaac caagaaaaga cagaagatca atatgaagaa      540

aattcacacc tcacctccgt tcctcattgg attaacagca atacattagg ttttggcaca      600

gagcaggcgc cctatggaat gcagacacag aattacccca aaggcggcct cctggacagc      660

atgtgtccgg cctccacacc cagcgtactc agctctgagc aggagtttca gatgttcccc      720

aagtctcggc tcagctccgt cagcgtcacc tactgctctg tcagtcagga cttcccaggc      780

agcaacttga atttgctcac caacaattct gggactccca aagaccacga ctcccctgag      840

aacggtgcgg acagcttcga gagctcagac tccctcctcc agtcctggaa cagccagtcg      900

tccttgctgg atgtgcaacg ggttccttcc ttcgagagct tcgaagatga ctgcagccag      960

tctctctgcc tcaataagcc aaccatgtct ttcaaggatt acatccaaga gaggagtgac     1020

ccagtggagc aaggcaaacc agttatacct gcagctgtgc tggccggctt cacaggaagt     1080

ggacctattc agctgtggca gtttctcctg gagctgctat cagacaaatc ctgccagtca     1140

ttcatcagct ggactggaga cggatgggag tttaagctcg ccgaccccga tgaggtggcc     1200

cgccggtggg gaaagaggaa aaataagccc aagatgaact acgagaagct gagccggggc     1260

ttacgctact attacgacaa gaacatcatc cacaagacgt cggggaagcg ctacgtgtac     1320

cgcttcgtgt gcgacctcca gaacttgctg gggttcacgc ccgaggaact gcacgccatc     1380

ctgggcgtcc agcccgacac ggaggactga                                      1410


<210>  277
<211>  1173
<212>  DNA
<213>  Homo sapiens;

<400>  277
atggacttct ggctttggcc actttacttc ctgccagtat cgggggccct gaggatcctc       60

ccagaagtaa aggtagaggg ggagctgggc ggatcagtta ccatcaagtg cccacttcct      120

gaaatgcatg tgaggatata tctgtgccgg gagatggctg gatctggaac atgtggtacc      180

gtggtatcca ccaccaactt catcaaggca gaatacaagg gccgagttac tctgaagcaa      240

tacccacgca agaatctgtt cctagtggag gtaacacagc tgacagaaag tgacagcgga      300

gtctatgcct gcggagcggg catgaacaca gaccggggaa agacccagaa agtcaccctg      360

aatgtccaca gtgaatacga gccatcatgg gaagagcagc caatgcctga gactccaaaa      420

tggtttcatc tgccctattt gttccagatg cctgcatatg ccagttcttc caaattcgta      480

accagagtta ccacaccagc tcaaaggggc aaggtccctc cagttcacca ctcctccccc      540

accacccaaa tcacccaccg ccctcgagtg tccagagcat cttcagtagc aggtgacaag      600

ccccgaacct tcctgccatc cactacagcc tcaaaaatct cagctctgga ggggctgctc      660

aagccccaga cgcccagcta caaccaccac accaggctgc acaggcagag agcactggac      720

tatggctcac agtctgggag ggaaggccaa ggatttcaca tcctgatccc gaccatcctg      780

ggccttttcc tgctggcact tctggggctg gtggtgaaaa gggccgttga aaggaggaaa      840

gccctctcca ggcgggcccg ccgactggcc gtgaggatgc gcgccctgga gagctcccag      900

aggccccgcg ggtcgccgcg accgcgctcc caaaacaaca tctacagcgc ctgcccgcgg      960

cgcgctcgtg gagcggacgc tgcaggcaca ggggaggccc ccgttcccgg ccccggagcg     1020

ccgttgcccc ccgccccgct gcaggtgtct gaatctccct ggctccatgc cccatctctg     1080

aagaccagct gtgaatacgt gagcctctac caccagcctg ccgccatgat ggaggacagt     1140

gattcagatg actacatcaa tgttcctgcc tga                                  1173


<210>  278
<211>  1632
<212>  DNA
<213>  Homo sapiens;

<400>  278
atggcgagcg gcggtggcgg gggtaacact ggcgcgggtg gggggccggg gatgggcctg       60

agcctgggcc tgggtctggg tctgagccta ggcatgagtg aggccaccag tgaggcagag      120

gaggaggcgg ccacggccga ggcggtggga cgcctggcca cgacgctgtg gctgcggctc      180

cgcggctggg aggcggtgct ggcggcggcg cagcggttgc tggtgtggga gaagccgctg      240

cacagcctgg tcacggcggc cgcgctcaac ggcctcttct ggttgctgtc ttcctcgtcc      300

ctccggccct tcttcctact cagcgtctca cttttggcct attttctgct ggatctctgg      360

cagcctcgct ttctccctga cgtttcagca tcatccccag aggagccaca ctctgacagt      420

gagggtgcgg ggtcaggcgc ccggccgcac ctgctgagtg tgcccgagtt gtgcagatac      480

ctggctgaga gctggctcac cttccagatt cacctgcagg agctgctgca gtacaagagg      540

cagaatccag ctcagttctg cgttcgagtc tgctctggct gtgctgtgtt ggctgtgttg      600

ggacactatg ttccagggat tatgatttcc tacattgtct tgttgagtat cctgctgtgg      660

cccctggtgg tttatcatga gctgatccag aggatgtaca ctcgcctgga gcccctgctc      720

atgcagctgg actacagcat gaaggcagaa gccaatgccc tgcatcacaa acacgacaag      780

aggaagcgtc aggggaagaa tgcaccccca ggaggtgatg agccactggc agagacagag      840

agtgaaagcg aggcagagct ggctggcttc tccccagtgg tggatgtgaa gaaaacagca      900

ttggccttgg ccattacaga ctcagagctg tcagatgagg aggcttctat cttggagagt      960

ggtggcttct ccgtatcccg ggccacaact ccgcagctga ctgatgtctc cgaggatttg     1020

gaccagcaga gcctgccaag tgaaccagag gagaccctaa gccgggacct aggggaggga     1080

gaggagggag agctggcccc tcccgaagac ctactaggcc gtcctcaagc tctgtcaagg     1140

caagccctgg actcggagga agaggaagag gatgtggcag ctaaggaaac cttgttgcgg     1200

ctctcatccc ccctccactt tgtgaacacg cacttcaatg gggcagggtc ccccccagat     1260

ggagtgaaat gctcccctgg aggaccagtg gagacactga gccccgagac agtgagtggt     1320

ggcctcactg ctctgcccgg caccctgtca cctccacttt gccttgttgg aagtgaccca     1380

gccccctccc cttccattct cccacctgtt ccccaggact caccccagcc cctgcctgcc     1440

cctgaggaag aagaggcact caccactgag gactttgagt tgctggatca gggggagctg     1500

gagcagctga atgcagagct gggcttggag ccagagacac cgccaaaacc ccctgatgct     1560

ccacccctgg ggcccgacat ccattctctg gtacagtcag accaagaagc tcaggccgtg     1620

gcagagccat ga                                                         1632


<210>  279
<211>  3207
<212>  DNA
<213>  Homo sapiens;

<400>  279
atgttggtag gatcccagtc tttttcgcct ggagggccca atgggatcat tagaagccag       60

tcctttgcgg gtttcagcgg cctccaggaa aggcgatcca ggtgtaactc cttcattgaa      120

aattcctccg ctctcaagaa gcctcaggcc aaactgaaga aaatgcacaa tttaggccac      180

aaaaacaaca atccccccaa agagcctcag cctaaaaggg tggaagaagt ctacagggcc      240

ttgaaaaatg gacttgatga atatctggag gttcaccaga cggagctgga caagttgaca      300

gctcagttaa aagatatgaa aagaaactct cgcctgggtg tactgtatga cctagacaag      360

caaattaaaa caattgaaag atacatgaga cgcctggagt ttcatataag taaggtagat      420

gaactctatg aagcttattg tatccagcga cgcctccagg atggtgccag caaaatgaag      480

caagccttcg caacatcccc tgccagcaaa gctgcccggg agagtctgac agagatcaat      540

cggagcttca aggagtacac agagaatatg tgcaccattg aagtggagct agagaatctg      600

ctgggagaat tctccatcaa gatgaaaggt ctggctggct ttgcacgcct ctgtcctgga      660

gatcaatatg aaattttcat gaagtatggc cggcagcggt ggaaactgaa aggcaaaata      720

gaagtaaatg gcaagcagag ctgggatgga gaagaaacag tttttctgcc cctgatagtt      780

gggttcatct ccatcaaggt cacggagctc aaagggctag caactcacat cctggtaggt      840

agcgtgacct gtgagaccaa agagctgttt gcagcccgac ctcaggtagt ggctgtcgac      900

atcaatgacc ttggtaccat caaactgaac ctggaaatca cctggtatcc atttgacgtg      960

gaggacatga ccgcatcctc aggcgctggg aacaaggcag cagcccttca gaggagaatg     1020

tccatgtaca gccagggtac cccggaaacg cccaccttca aagaccactc cttctttagg     1080

tggctgcatc cttccccaga caagcccagg cggctgtctg tcttgagtgc cttgcaagac     1140

actttctttg ccaagctgca ccgcagccgc tccttcagtg acctgccctc cctcaggccg     1200

agtcccaagg ccgtgctaga gctctattca aatctacctg atgacatctt tgaaaatgga     1260

aaggcagccg aggagaaaat gccactgtcg ctcagcttca gtgacctgcc caacggggac     1320

tgcgccctca cctcccactc aacaggctcc ccttccaact caacaaatcc agaaattacc     1380

atcacccctg cggagtttaa cctcagcagc ttggcctccc agaatgaggg tatggatgac     1440

accagctcag catcttccag gaactccctg ggagaaggcc aagagccaaa gtcacacctg     1500

aaggaggaag acccagagga gcccagaaaa cctgcctcgg ccccatctga ggcttgccgc     1560

cgacagtcct caggtgctgg ggctgagcac ctgttccttg agaatgatgt tgcagaagca     1620

cttctgcaag agtctgagga ggcctctgag ctcaagcctg tggaactgga cacttcggaa     1680

ggaaacatca caaagcagct ggtcaagagg ctcacatctg cagaggtgcc aatggccaca     1740

gacaggctgc tctctgaggg ttctgttggt ggagaatctg aaggctgcag atcctttcta     1800

gatggaagct tagaggatgc ttttaatggg cttttacttg cattagaacc acataaagag     1860

cagtataaag agtttcagga tctgaaccaa gaagtcatga atttggatga tattctaaaa     1920

tgcaagccag cagtaagccg cagcaggtct tccagtttaa gtctcacagt tgaaagtgct     1980

ttagaaagct ttgatttcct gaacacctct gattttgacg aggaggagga tggtgatgag     2040

gtttgtaatg ttggcggagg tgctgactca gtattttcag acactgagac tgagaaacac     2100

agttacaggt cggttcaccc agaagccagg gggcatctca gtgaagcgct cactgaagac     2160

acaggagttg ggaccagtgt ggcaggaagt cctctcccac tgaccacagg caacgagagc     2220

ctggacatca ccatcgtcag gcacctccag tactgcaccc aactcgtgca gcaaattgtt     2280

ttctcaagca aaaccccatt tgtggcaaga agtctcttag agaagctttc taggcagatc     2340

caagtgatgg agaaactcgc agctgtcagt gatgagaaca taggaaatat cagttctgtt     2400

gtggaagcca taccagaatt tcacaaaaag ctgtctttgc tgtcattctg gaccaagtgc     2460

tgcagccctg ttggtgtcta ccacagccca gcggacagag tgatgaagca gctggaggcc     2520

agctttgcca gaactgtcaa caaagaatat ccaggacttg cagacccagt gtttcgaacc     2580

ctggtgtccc aaattctgga ccgggctgag cctctgcttt cctccagcct gtcctcggaa     2640

gtcgtcactg ttttccagta ttacagttac ttcaccagcc acggcgtcag tgacctggag     2700

agttacctga gccagctggc caggcaagtt tccatggttc agactctgca atcactaaga     2760

gatgaaaaac tgctacaaac catgagtgac cttgctccca gcaacctcct ggcccagcag     2820

gaagtactca ggactctggc tctgctatta accagagagg acaacgaagt tagtgaggct     2880

gtgacgcttt acttggcagc agcctccaaa aatcagcatt tcagggaaaa ggccttgctc     2940

tattactgtg aagcactaac aaagacaaac ctccagctcc agaaagcagc ttgcctggct     3000

ctgaaaatcc ttgaggctac tgaaagcatt aaaatgctgg tgacattgtg tcaatctgat     3060

actgaagaaa tcagaaatgt ggcctcagaa accctcttgt ctctgggaga agatgggcgg     3120

ctggcatatg aacaattgga caaatttcct cgagactgtg ttaaagtcgg aggtcgtcat     3180

ggaactgaag ttgccacagc cttttaa                                         3207


<210>  280
<211>  2532
<212>  DNA
<213>  Homo sapiens;

<400>  280
atggttgcag aagaatcagg tcctggtgca caaaatagtc cataccaact tcgtagaaaa       60

actcttttgc cgaaaagaac agcgtgtccc acaaagaaca gtatggaggg cgcctcaact      120

tcaactacag aaaactttgg tcatcgtgca aaacgtgcaa gagtgtctgg aaaatcacaa      180

gatctatcag cagcacctgc tgaacagtat cttcaggaga aactgccaga tgaagtggtt      240

ctaaaaatct tctcttactt gctggaacag gatctttgta gagcagcttg tgtatgtaaa      300

cgcttcagtg aacttgctaa tgatccaatt ttgtggaaac gattatatat ggaagtattt      360

gaatatactc gccctatgat gcatcctgaa cctggaaaat tctaccagat taatccagaa      420

gagtatgaac atccaaatcc ctggaaagag agtttccagc agttgtataa aggtgcacat      480

gtaaagccag gatttgctga acatttctac agtaaccctg caagatataa aggaagagaa      540

aatatgttgt attatgatac tattgaagat gcccttggtg gggtacaaga ggctcatttt      600

gatggactta tctttgttca ttctggaata tatactgatg aatggatata tattgaatct      660

ccaatcacca tgattggtgc agcacctggg aaagtggcag acaaagttat aattgaaaac      720

actagagatt caaccttcgt ttttatggaa ggctctgaag atgcttatgt tggatatatg      780

acaataaggt ttaaccctga tgacaaatct gcacaacacc acaatgcaca ccactgctta      840

gagattacag taaattgtag ccctattatt gatcactgta tcatccgaag tacatgtaca      900

gttggttctg cagtatgtgt tagtggtcaa ggagcatgtc ccaccatcaa gcactgtaac      960

atcagtgact gtgaaaatgt tggactatat ataacagatc atgcacaggg aatatatgag     1020

gataatgaaa tttccaataa tgcgttagct gggatttggg ttaaaaatca tggaaaccca     1080

attattagac ggaatcatat tcatcatgga cgtgatgttg gtgtgttcac atttgatcat     1140

ggcatgggtt actttgaaag ttgcaatata cacagaaata ggatagcagg ctttgaagta     1200

aaagcctatg ctaaccctac agtggttcga tgtgaaattc accatgggca gactggagga     1260

atatatgtcc atgaaaaagg aagaggacaa ttcatagaga ataaaatcta tgcaaacaac     1320

tttgcaggtg tatggattac ctcaaatagt gacccaacaa taaggggaaa ttctatattt     1380

aatggaaatc aaggaggagt ttacatcttt ggtgatggac gaggccttat tgaaggaaat     1440

gacatttatg gcaatgcatt agcaggaatt caaattagga caaacagttg tccaattgtt     1500

cggcataaca aaattcatga tggccagcat ggtgggattt atgtgcatga aaagggacaa     1560

ggagtaatag aagagaatga agtttatagt aacactctag ctggagtctg ggtgacaact     1620

ggcagcactc cagtactgag aagaaaccgg atacacagtg gcaagcaggt tggtgtttat     1680

ttttatgaca atggacatgg agtgctagaa gacaatgata tctataatca tatgtattca     1740

ggggttcaga taaggactgg aagcaacccc aaaattagac gcaacaaaat ctggggagga     1800

cagaatggtg gaattctagt ttataattct ggtctaggct gtatagaaga caatgaaata     1860

tttgacaatg caatggctgg agtctggatt aagacagata gtaatcctac actaagaaga     1920

aataaaatcc atgatggaag agatggtggc atctgtatat ttaatggggg tcgaggtctc     1980

cttgaagaaa atgatatttt caggaatgct caagcaggtg ttctcatcag cactaatagt     2040

catccaatct taaggaaaaa cagaatattt gatggatttg ccgcaggtat tgaaattaca     2100

aatcacgcaa ctgcaacact agaaggcaat cagattttta acaaccggtt tggaggctta     2160

tttttagcat ctggtgttaa tgtgacaatg aaagataaca aaataatgaa caatcaagat     2220

gccatagaaa aggctgttag tagaggccaa tgtttatata aaatatcaag ttataccagc     2280

tatcccatgc atgatttcta cagatgtcat acttgtaaca ccacagatcg aaatgccata     2340

tgtgtgaact gcattaagaa gtgccatcag ggacatgatg tagagtttat tagacatgat     2400

aggtttttct gtgactgtgg tgctggaaca ctgtctaatc cttgtacatt agctggtgag     2460

cctacacatg atacagatac actatatgac tctgctccac ctatagaatc taatacattg     2520

cagcacaact ga                                                         2532


<210>  281
<211>  1344
<212>  DNA
<213>  Homo sapiens;

<400>  281
atgcctgaca ttatttgggt tttcccccct caggcagaag ctgaggaaga ttgtcattct       60

gatactgtca gagcagatga tgatgaagaa aatgaaagtc ctgctgaaac agatctgcag      120

gcacaactcc agatgttccg agctcagtgg atgtttgaac ttgctccagg tgtaagctct      180

agcaatttag aaaatcgacc ttgcagagca gcaagaggct ctctccagaa aacatcggca      240

gataccaaag gaaaacaaga acaggcaaaa gaagaaaagg ctcgagaact cttcctaaaa      300

gcagtagaag aagaacaaaa tggagctctc tatgaagcca tcaagtttta tcgtagggct      360

atgcaacttg tacctgatat agagttcaag attacttata cccggtctcc agatggtgat      420

ggcgttggaa acagctacat tgaagataat gatgatgaca gcaaaatggc agatctcttg      480

tcctacttcc agcagcaact cacatttcag gagtctgtgc ttaaactgtg tcagcctgag      540

cttgagagca gtcagattca catatcagtg ctgccaatgg aggtcctgat gtacatcttc      600

cgatgggtgg tgtctagtga cttggacctc agatcattgg agcagttgtc gctggtgtgc      660

agaggattct acatctgtgc cagagaccct gaaatatggc gtctggcctg cttgaaagtt      720

tggggcagaa gctgtattaa acttgttccg tacacgtcct ggagagagat gtttttagaa      780

cggcctcgtg ttcggtttga tggcgtgtat atcagtaaaa ccacatatat tcgtcaaggg      840

gaacagtctc ttgatggttt ctatagagcc tggcaccaag tggaatatta caggtacata      900

agattctttc ctgatggcca tgtgatgatg ttgacaaccc ctgaagagcc tcagtccatt      960

gttccacgtt taagaactag gaataccagg actgatgcaa ttctactggg tcactatcgc     1020

ttgtcacaag acacagacaa tcagaccaaa gtatttgctg taataactaa gaaaaaagaa     1080

gaaaaaccac ttgactataa atacagatat tttcgtcgtg tccctgtaca agaagcagat     1140

cagagttttc atgtggggct acagctatgt tccagtggtc accagaggtt caacaaactc     1200

atctggatac atcattcttg tcacattact tacaaatcaa ctggtgagac tgcagtcagt     1260

gcttttgaga ttgacaagat gtacaccccc ttgttcttcg ccagagtaag gagctacaca     1320

gctttctcag aaaggcctct gtag                                            1344


<210>  282
<211>  1098
<212>  DNA
<213>  Homo sapiens;

<400>  282
atgggggtcc cgcggcctca gccctgggcg ctggggctcc tgctctttct ccttcctggg       60

agcctgggcg cagaaagcca cctctccctc ctgtaccacc ttaccgcggt gtcctcgcct      120

gccccgggga ctcctgcctt ctgggtgtcc ggctggctgg gcccgcagca gtacctgagc      180

tacaatagcc tgcggggcga ggcggagccc tgtggagctt gggtctggga aaaccaggtg      240

tcctggtatt gggagaaaga gaccacagat ctgaggatca aggagaagct ctttctggaa      300

gctttcaaag ctttgggggg aaaaggtccc tacactctgc agggcctgct gggctgtgaa      360

ctgggccctg acaacacctc ggtgcccacc gccaagttcg ccctgaacgg cgaggagttc      420

atgaatttcg acctcaagca gggcacctgg ggtggggact ggcccgaggc cctggctatc      480

agtcagcggt ggcagcagca ggacaaggcg gccaacaagg agctcacctt cctgctattc      540

tcctgcccgc accgcctgcg ggagcacctg gagaggggcc gcggaaacct ggagtggaag      600

gagcccccct ccatgcgcct gaaggcccga cccagcagcc ctggcttttc cgtgcttacc      660

tgcagcgcct tctccttcta ccctccggag ctgcaacttc ggttcctgcg gaatgggctg      720

gccgctggca ccggccaggg tgacttcggc cccaacagtg acggatcctt ccacgcctcg      780

tcgtcactaa cagtcaaaag tggcgatgag caccactact gctgcattgt gcagcacgcg      840

gggctggcgc agcccctcag ggtggagctg gaatctccag ccaagtcctc cgtgctcgtg      900

gtgggaatcg tcatcggtgt cttgctactc acggcagcgg ctgtaggagg agctctgttg      960

tggagaagga tgaggagtgg gctgccagcc ccttggatct cccttcgtgg agacgacacc     1020

ggggtcctcc tgcccacccc aggggaggcc caggatgctg atttgaagga tgtaaatgtg     1080

attccagcca ccgcctga                                                   1098


<210>  283
<211>  2469
<212>  DNA
<213>  Homo sapiens;

<400>  283
atgggcttct cttccgagct gtgcagcccc cagggccacg gggtcctgca gcaaatgcag       60

gaggccgagc ttcgtctact ggagggcatg agaaagtgga tggcccagcg ggtcaagagt      120

gacagggagt atgcaggact gcttcaccac atgtccctgc aggacagtgg gggccagagc      180

cgggccatca gccctgacag ccccatcagt cagtcctggg ctgagatcac cagccaaact      240

gagggcctga gccgcttgct gcggcagcac gcagaggatc tgaactcagg gcccctgagc      300

aagctgagcc tgctcatccg ggaacggcag cagcttcgca agacctacag cgagcagtgg      360

cagcagctgc agcaggagct caccaagacc cacagccagg acattgagaa gctgaagagc      420

cagtaccgag ctctggcacg ggacagtgcc caagccaagc gcaagtacca ggaggccagc      480

aaagacaagg accgtgacaa ggctaaggac aagtatgtgc gcagcctgtg gaagctcttt      540

gctcaccaca accgctatgt gctgggcgtg cgggctgcgc agctacacca ccagcaccac      600

caccagctcc tgctgcccgg cctgctgcgg tcactgcagg acctgcacga ggagatggct      660

tgcatcctga aggagatcct gcaggaatac ctggagatta gcagcctggt gcaggatgag      720

gtggtggcca ttcaccggga gatggctgca gctgctgccc gcatccagcc tgaggctgag      780

taccaaggct tcctgcgaca gtatgggtcc gcacctgacg tcccaccctg tgtcacgttc      840

gatgagtcac tgcttgagga gggtgaaccg ctggagcctg gggagctcca gctgaacgag      900

ctgactgtgg agagcgtgca gcacacgctg acctcagtga cagatgagct ggctgtggcc      960

accgagatgg tgttcaggcg gcaggagatg gttacgcagc tgcaacagga gctccggaat     1020

gaagaggaga acacccaccc ccgggagcgg gtgcagctgc tgggcaagag gcaagtgctg     1080

caagaagcac tgcaggggct gcaggtagcg ctgtgcagcc aggccaagct gcaggcccag     1140

caggagttgc tgcagaccaa gctggagcac ctgggccccg gcgagccccc gcctgtgctg     1200

ctcctgcagg atgaccgcca ctccacgtcg tcctcggagc aggagcgaga ggggggaagg     1260

acacccacgc tggagatcct taagagccac atctcaggaa tcttccgccc caagttctcg     1320

ctccctccac cgctgcagct cattccggag gtgcagaagc ccctgcatga gcagctgtgg     1380

taccacgggg ccatcccgag ggcagaggtg gctgagctgc tggtgcactc tggggacttc     1440

ctggtgcggg agagccaggg caagcaggag tacgtgctgt cggtgctgtg ggatggtctg     1500

ccccggcact tcatcatcca gtccttggat aacctgtacc gactggaagg ggaaggcttt     1560

cctagcattc ctttgctcat cgaccaccta ctgagcaccc agcagcccct caccaagaag     1620

agtggtgttg tcctgcacag ggctgtgccc aaggacaagt gggtgctgaa ccatgaggac     1680

ctggtgttgg gtgagcagat tggacggggg aactttggcg aagtgttcag cggacgcctg     1740

cgagccgaca acaccctggt ggcggtgaag tcttgtcgag agacgctccc acctgacctc     1800

aaggccaagt ttctacagga agcgaggatc ctgaagcagt acagccaccc caacatcgtg     1860

cgtctcattg gtgtctgcac ccagaagcag cccatctaca tcgtcatgga gcttgtgcag     1920

gggggcgact tcctgacctt cctccgcacg gagggggccc gcctgcgggt gaagactctg     1980

ctgcagatgg tgggggatgc agctgctggc atggagtacc tggagagcaa gtgctgcatc     2040

caccgggacc tggctgctcg gaactgcctg gtgacagaga agaatgtcct gaagatcagt     2100

gactttggga tgtcccgaga ggaagccgat ggggtctatg cagcctcagg gggcctcaga     2160

caagtccccg tgaagtggac cgcacctgag gcccttaact acggccgcta ctcctccgaa     2220

agcgacgtgt ggagctttgg catcttgctc tgggagacct tcagcctggg ggcctccccc     2280

tatcccaacc tcagcaatca gcagacacgg gagtttgtgg agaagggggg ccgtctgccc     2340

tgcccagagc tgtgtcctga tgccgtgttc aggctcatgg agcagtgctg ggcctatgag     2400

cctgggcagc ggcccagctt cagcaccatc taccaggagc tgcagagcat ccgaaagcgg     2460

catcggtga                                                             2469


<210>  284
<211>  1590
<212>  DNA
<213>  Homo sapiens;

<400>  284
atgggctgtg tgttctgcaa gaaattggag ccggtggcca cggccaagga ggatgctggc       60

ctggaagggg acttcagaag ctacggggca gcagaccact atgggcctga ccccactaag      120

gcccggcctg catcctcatt tgcccacatc cccaactaca gcaacttctc ctctcaggcc      180

atcaaccctg gcttccttga tagtggcacc atcaggggtg tgtcagggat tggggtgacc      240

ctgttcattg ccctgtatga ctatgaggct cgaactgagg atgacctcac cttcaccaag      300

ggcgagaagt tccacatcct gaacaatact gaaggtgact ggtgggaggc tcggtctctc      360

agctccggaa aaactggctg cattcccagc aactacgtgg cccctgttga ctcaatccaa      420

gctgaagagt ggtactttgg aaagattggg agaaaggatg cagagaggca gctgctttca      480

ccaggcaacc cccagggggc ctttctcatt cgggaaagcg agaccaccaa aggtgcctac      540

tccctgtcca tccgggactg ggatcagacc agaggcgatc atgtgaagca ttacaagatc      600

cgcaaactgg acatgggcgg ctactacatc accacacggg ttcagttcaa ctcggtgcag      660

gagctggtgc agcactacat ggaggtgaat gacgggctgt gcaacctgct catcgcgccc      720

tgcaccatca tgaagccgca gacgctgggc ctggccaagg acgcctggga gatcagccgc      780

agctccatca cgctggagcg ccggctgggc accggctgct tcggggatgt gtggctgggc      840

acgtggaacg gcagcactaa ggtggcggtg aagacgctga agccgggcac catgtccccg      900

aaggccttcc tggaggaggc gcaggtcatg aagctgctgc ggcacgacaa gctggtgcag      960

ctgtacgccg tggtgtcgga ggagcccatc tacatcgtga ccgagttcat gtgtcacggc     1020

agcttgctgg attttctcaa gaacccagag ggccaggatt tgaggctgcc ccaattggtg     1080

gacatggcag cccaggtagc tgagggcatg gcctacatgg aacgcatgaa ctacattcac     1140

cgcgacctga gggcagccaa catcctggtt ggggagcggc tggcgtgcaa gatcgcagac     1200

tttggcttgg cgcgtctcat caaggacgat gagtacaacc cctgccaagg ttccaagttc     1260

cccatcaagt ggacagcccc agaagctgcc ctctttggca gattcaccat caagtcagac     1320

gtgtggtcct ttgggatcct gctcactgag ctcatcacca agggccgaat cccctaccca     1380

ggcatgaata aacgggaagt gttggaacag gtggagcagg gctaccacat gccgtgccct     1440

ccaggctgcc cagcatccct gtacgaggcc atggaacaga cctggcgtct ggacccggag     1500

gagaggccta ccttcgagta cctgcagtcc ttcctggagg actacttcac ctccgctgaa     1560

ccacagtacc agcccgggga tcagacatag                                      1590


<210>  285
<211>  1287
<212>  DNA
<213>  Homo sapiens;

<400>  285
atgggcaatt gccacacggt ggggcccaac gaggcgctgg tggtttcagg gggctgttgt       60

ggttccgact ataaacagta cgtgtttggc ggctgggcct gggcctggtg gtgtatctcc      120

gacactcaga ggatttccct agagattatg acgttgcagc cccgctgcga ggacgtagag      180

acggccgagg gggtagcttt aactgtgacg ggtgtcgccc aggtgaagat catgacggag      240

aaggaactcc tggccgtggc ttgtgagcag tttctgggta agaatgtgca ggacatcaaa      300

aacgtcgtcc tgcagaccct ggagggacat ctgcgctcca tcctcgggac cctgacagtg      360

gagcagattt atcaggaccg ggaccagttt gccaagctgg tgcgggaggt ggcagcccct      420

gatgttggcc gcatgggcat tgagatcctc agcttcacca tcaaggacgt gtatgacaaa      480

gtggactatc tgagctccct gggcaagacg cagactgccg tggtgcagag agatgctgac      540

attggcgtgg ccgaggctga acgggacgca ggcatccggg aagctgagtg caagaaggag      600

atgctggatg tgaagttcat ggcagacacc aagattgctg actctaagcg agccttcgag      660

ctgcaaaagt cagccttcag tgaggaggtt aacatcaaga cagctgaggc ccagttggcc      720

tatgagctgc agggggcccg tgaacagcag aagatccggc aggaagagat tgagattgag      780

gttgtgcagc gcaagaaaca gattgccgtg gaggcacagg agatcctgcg tacggacaag      840

gagctcatcg ctacagtgcg ccggcctgcc gaggccgagg cccaccgcat ccagcagatt      900

gccgagggtg aaaaggtgaa gcaggtcctc ttggcacagg cagaggctga gaagatccgc      960

aaaatcgggg aggcggaagc ggcagtcatc gaggcgatgg gcaaggcaga ggctgagcgg     1020

atgaagctca aggcagaagc ctaccagaaa tacggggatg cagccaagat ggccttggtg     1080

ctagaggccc tgccccagat tgctgccaaa atcgctgccc cacttaccaa ggtcgatgag     1140

attgtggtcc tcagtggaga caacagtaag gtcacatcag aagtgaaccg actgctggcc     1200

gagctgcctg cctctgtgca tgccctcaca ggcgtggacc tgtctaagat acccctgatc     1260

aagaaggcca ctggtgtgca ggtgtga                                         1287


<210>  286
<211>  1854
<212>  DNA
<213>  Homo sapiens;

<400>  286
atgagctggg gcaccgagct ctgggatcag tttgacaact tagaaaaaca cacacagtgg       60

ggaattgata ttcttgagaa atatatcaag tttgtgaaag aaaggacaga gattgaactc      120

agctatgcaa agcaactcag gaatctttca aagaagtacc aacctaaaaa gaactcgaag      180

gaggaagaag aatacaagta tacgtcatgt aaagctttca tttccaacct gaacgaaatg      240

aatgattacg cagggcagca tgaagttatc tccgagaaca tggcatcaca gatcattgtg      300

gacttggcac gctatgttca ggaactgaaa caggagagga aatcaaactt tcacgatggc      360

cgtaaagcac agcagcacat cgagacttgc tggaagcagc ttgaatctag taaaaggcga      420

tttgaacgcg attgcaaaga ggcggacagg gcgcagcagt actttgagaa aatggacgct      480

gacatcaatg tcacaaaagc ggatgttgaa aaggcccgac aacaagctca aatacgtcac      540

caaatggcag aggacagcaa agcagattac tcatccattc tccagaaatt caaccatgag      600

cagcatgaat attaccatac tcacatcccc aacatcttcc agaaaataca agagatggag      660

gaaaggagga ttgtgagaat gggagagtcc atgaagacat atgcagaggt tgatcggcag      720

gtgatcccaa tcattgggaa gtgcctggat ggaatagtaa aagcagccga atcaattgat      780

cagaaaaatg attcacagct ggtaatagaa gcttataaat cagggtttga gcctcctgga      840

gacattgaat ttgaggatta cactcagcca atgaagcgca ctgtgtcaga taacagcctt      900

tcaaattcca gaggagaagg caaaccagac ctcaaatttg gtggcaaatc caaaggaaag      960

ttatggccgt tcatcaaaaa aaataagctt atgtcccttt taacatcccc ccatcagcct     1020

ccccctcccc ctcctgcctc tgcctcaccc tctgctgttc ccaacggccc ccagtctccc     1080

aagcagcaaa aggaacccct ctcccatcgc ttcaacgagt tcatgacctc caaacccaaa     1140

atccactgct tcaggagcct aaagcgtggg ctttctctca agctgggtgc aacaccggag     1200

gatttcagca acctcccacc tgaacaaaga aggaaaaagc tgcagcagaa agtcgatgag     1260

ttaaataaag aaattcagaa ggagatggat caaagagatg ccataacaaa aatgaaagat     1320

gtctacctaa agaatcctca gatgggagac ccagccagtt tggatcacaa attagcagaa     1380

gtcagccaaa atatagagaa actgcgagta gagacccaga aatttgaggc ctggctggct     1440

gaggttgaag gccggctccc agcacgcagc gagcaggcgc gccggcagag cggactgtac     1500

gacagccaga acccacccac agtcaacaac tgcgcccagg accgtgagag cccagatggc     1560

agttacacag aggagcagag tcaggagagt gagatgaagg tgctggccac ggattttgac     1620

gacgagtttg atgatgagga gcccctccct gccataggga cgtgcaaagc tctctacaca     1680

tttgaaggtc agaatgaagg aacgatttcc gtagttgaag gagaaacatt gtatgtcata     1740

gaggaagaca aaggcgatgg ctggacccgc attcggagaa atgaagatga agagggttat     1800

gtccccactt catatgtcga agtctgtttg gacaaaaatg ccaaagattc ctag           1854


<210>  287
<211>  1725
<212>  DNA
<213>  Homo sapiens;

<400>  287
atggcttctg acctagagag tagcctcacc tccatagact ggctccccca gctgaccctc       60

cgagctacca ttgagaagct tggaagtgcc tcccaggctg ggcctcccgg gagcagccgc      120

aagtgttcac cagggtcacc cacagatcct aatgccaccc tgagcaaaga cgaggcagca      180

gtgcaccagg acggcaagcc acgatacagc tatgccactc tcatcaccta tgccatcaac      240

tcctctccag ccaagaagat gaccctcagc gagatttacc gctggatctg tgataacttc      300

ccctattaca agaatgctgg cattggttgg aagaattcaa tacggcacaa cctttctctc      360

aacaagtgtt tccggaaggt gcccagacct cgggatgacc ctgggaaggg ttcctattgg      420

acaattgaca cctgccctga catttcccga aagagaagac accctccaga tgatgatctg      480

tcccaagact caccagaaca ggaggcaagc aagagcccac ggggaggcgt tgcagggagt      540

ggagaagcct cactgcctcc tgaggggaat ccgcagatgt cacttcagag ccccacatct      600

atagccagct acagccaggg cacaggatct gtggatggtg gagcagtggc agcaggggct      660

tcaggccgag aaagtgctga gggtccccct cccctctata acaccaacca tgactttaaa      720

ttctcctact cagagatcaa ctttcaggat ctaagctggt ccttccgcaa cctctataag      780

tccatgctgg agaagtcctc ttcctcctct cagcacggct tttcttctct cctgggggac      840

atcccaccct cgaacaacta ctacatgtat cagcagcagc agccaccgcc acctcaacag      900

cagcagcagc agcagcagcc gccacagcca cctccccagc agtcccagcc acagcagcag      960

caggcacctg cccagggccc ctcagctgta gggggtgctc ctccactgca caccccaagc     1020

acagatggtt gtaccccacc agggggaaag caagctgggg cggaaggcta tgggcctccc     1080

cctgtaatgg ccatgcatcc acccccgctg cagcatggag gctaccaccc tcatcagcac     1140

catccccact cccaccctgc ccagcagcca ccacctccac agccacaggc acaaggccag     1200

gctcccatca acaacactgg ctttgccttt ccttctgact ggtgctctaa tattgactct     1260

ttaaaggaaa gcttcaagat ggtgaatcgg ctcaattggt ccagcattga gcagtcacaa     1320

ttctcagaac tgatggagag tctacgacag gcagagcaga agaactggac cctcgaccag     1380

catcacattg ccaatctgtg tgactccctc aaccacttcc ttactcagac tggtcacgtg     1440

ccccctcaag ggggtaccca ccgcccacca gcccctgccc gtattgctga ctcctgtgcc     1500

ctcaccagtg gcaaacagga gtcagccatg agccaagtga actcttatgg gcacccacaa     1560

gctccccacc tctaccctgg cccatcacca atgtacccaa tccccaccca ggactcagca     1620

ggatacaatc gcccagcaca ccatatggtc cctcggccat cagtgccacc tcctggtgcc     1680

aatgaggaga tccctgatga cttcgactgg gacttgatca cttag                     1725


<210>  288
<211>  1968
<212>  DNA
<213>  Homo sapiens;

<400>  288
atggccgagg cgcctcaggt ggtggagatc gacccggact tcgagccgct gccccggccg       60

cgctcgtgca cctggccgct gcccaggccg gagtttagcc agtccaactc ggccacctcc      120

agcccggcgc cgtcgggcag cgcggctgcc aaccccgacg ccgcggcggg cctgccctcg      180

gcctcggctg ccgctgtcag cgccgacttc atgagcaacc tgagcttgct ggaggagagc      240

gaggacttcc cgcaggcgcc cggctccgtg gcggcggcgg tggcggcggc ggccgccgcg      300

gccgccaccg gggggctgtg cggggacttc cagggcccgg aggcgggctg cctgcaccca      360

gcgccaccgc agcccccgcc gcccgggccg ctgtcgcagc acccgccggt gccccccgcc      420

gccgctgggc cgctcgcggg gcagccgcgc aagagcagct cgtcccgccg caacgcgtgg      480

ggcaacctgt cctacgccga cctcatcacc aaggccatcg agagctcggc ggagaagcgg      540

ctcacgctgt cgcagatcta cgagtggatg gtcaagagcg tgccctactt caaggataag      600

ggtgacagca acagctcggc gggctggaag aattcaattc gtcataatct gtccctacac      660

agcaagttca ttcgtgtgca gaatgaagga actggaaaaa gttcttggtg gatgctcaat      720

ccagagggtg gcaagagcgg gaaatctcct aggagaagag ctgcatccat ggacaacaac      780

agtaaatttg ctaagagccg aagccgagct gccaagaaga aagcatctct ccagtctggc      840

caggagggtg ctggggacag ccctggatca cagttttcca aatggcctgc aagccctggc      900

tctcacagca atgatgactt tgataactgg agtacatttc gccctcgaac tagctcaaat      960

gctagtacta ttagtgggag actctcaccc attatgaccg aacaggatga tcttggagaa     1020

ggggatgtgc attctatggt gtacccgcca tctgccgcaa agatggcctc tactttaccc     1080

agtctgtctg agataagcaa tcccgaaaac atggaaaatc ttttggataa tctcaacctt     1140

ctctcatcac caacatcatt aactgtttcg acccagtcct cacctggcac catgatgcag     1200

cagacgccgt gctactcgtt tgcgccacca aacaccagtt tgaattcacc cagcccaaac     1260

taccaaaaat atacatatgg ccaatccagc atgagccctt tgccccagat gcctatacaa     1320

acacttcagg acaataagtc gagttatgga ggtatgagtc agtataactg tgcgcctgga     1380

ctcttgaagg agttgctgac ttctgactct cctccccata atgacattat gacaccagtt     1440

gatcctgggg tagcccagcc caacagccgg gttctgggcc agaacgtcat gatgggccct     1500

aattcggtca tgtcaaccta tggcagccag gcatctcata acaaaatgat gaatcccagc     1560

tcccataccc accctggaca tgctcagcag acatctgcag ttaacgggcg tcccctgccc     1620

cacacggtaa gcaccatgcc ccacacctcg ggtatgaacc gcctgaccca agtgaagaca     1680

cctgtacaag tgcctctgcc ccaccccatg cagatgagtg ccctgggggg ctactcctcc     1740

gtgagcagct gcaatggcta tggcagaatg ggccttctcc accaggagaa gctcccaagt     1800

gacttggatg gcatgttcat tgagcgctta gactgtgaca tggaatccat cattcggaat     1860

gacctcatgg atggagatac attggatttt aactttgaca atgtgttgcc caaccaaagc     1920

ttcccacaca gtgtcaagac aacgacacat agctgggtgt caggctga                  1968


<210>  289
<211>  2022
<212>  DNA
<213>  Homo sapiens;

<400>  289
atggcagagg caccggcttc cccggccccg ctctctccgc tcgaagtgga gctggacccg       60

gagttcgagc cccagagccg tccgcgatcc tgtacgtggc ccctgcaaag gccggagctc      120

caagcgagcc ctgccaagcc ctcgggggag acggccgccg actccatgat ccccgaggag      180

gaggacgatg aagacgacga ggacggcggg ggacgggccg gctcggccat ggcgatcggc      240

ggcggcggcg ggagcggcac gctgggctcc gggctgctcc ttgaggactc ggcccgggtg      300

ctggcacccg gagggcaaga ccccgggtct gggccagcca ccgcggcggg cgggctgagc      360

gggggtacac aggcgctgct gcagcctcag caaccgctgc caccgccgca gccgggggcg      420

gctgggggct ccgggcagcc gaggaaatgt tcgtcgcggc ggaacgcctg gggaaacctg      480

tcctacgcgg acctgatcac ccgcgccatc gagagctccc cggacaaacg gctcactctg      540

tcccagatct acgagtggat ggtgcgttgc gtgccctact tcaaggataa gggcgacagc      600

aacagctctg ccggctggaa gaactccatc cggcacaacc tgtcactgca tagtcgattc      660

atgcgggtcc agaatgaggg aactggcaag agctcttggt ggatcatcaa ccctgatggg      720

gggaagagcg gaaaagcccc ccggcggcgg gctgtctcca tggacaatag caacaagtat      780

accaagagcc gtggccgcgc agccaagaag aaggcagccc tgcagacagc ccccgaatca      840

gctgacgaca gtccctccca gctctccaag tggcctggca gccccacgtc acgcagcagt      900

gatgagctgg atgcgtggac ggacttccgt tcacgcacca attctaacgc cagcacagtc      960

agtggccgcc tgtcgcccat catggcaagc acagagttgg atgaagtcca ggacgatgat     1020

gcgcctctct cgcccatgct ctacagcagc tcagccagcc tgtcaccttc agtaagcaag     1080

ccgtgcacgg tggaactgcc acggctgact gatatggcag gcaccatgaa tctgaatgat     1140

gggctgactg aaaacctcat ggacgacctg ctggataaca tcacgctccc gccatcccag     1200

ccatcgccca ctgggggact catgcagcgg agctctagct tcccgtatac caccaagggc     1260

tcgggcctgg gctccccaac cagctccttt aacagcacgg tgttcggacc ttcatctctg     1320

aactccctac gccagtctcc catgcagacc atccaagaga acaagccagc taccttctct     1380

tccatgtcac actatggtaa ccagacactc caggacctgc tcacttcgga ctcacttagc     1440

cacagcgatg tcatgatgac acagtcggac cccttgatgt ctcaggccag caccgctgtg     1500

tctgcccaga attcccgccg gaacgtgatg cttcgcaatg atccgatgat gtcctttgct     1560

gcccagccta accagggaag tttggtcaat cagaacttgc tccaccacca gcaccaaacc     1620

cagggcgctc ttggtggcag ccgtgccttg tcgaattctg tcagcaacat gggcttgagt     1680

gagtccagca gccttgggtc agccaaacac cagcagcagt ctcctgtcag ccagtctatg     1740

caaaccctct cggactctct ctcaggctcc tccttgtact caactagtgc aaacctgccc     1800

gtcatgggcc atgagaagtt ccccagcgac ttggacctgg acatgttcaa tgggagcttg     1860

gaatgtgaca tggagtccat tatccgtagt gaactcatgg atgctgatgg gttggatttt     1920

aactttgatt ccctcatctc cacacagaat gttgttggtt tgaacgtggg gaacttcact     1980

ggtgctaagc aggcctcatc tcagagctgg gtgccaggct ga                        2022


<210>  290
<211>  9042
<212>  DNA
<213>  Homo sapiens;

<400>  290
atggccagcc agcaggattc gggcttcttt gagatcagta tcaaatattt actgaaatcc       60

tggagtaata cttctcccgt tggcaacggt tacatcaagc ctccggttcc acctgcttct      120

ggcacgcaca gggagaaagg gccgccaacc atgctaccca tcaatgtgga cccagacagt      180

aaaccaggag aatatgtcct caaaagttta tttgtcaact tcaccactca ggctgaacgc      240

aagattcgta tcattatggc agagcccctg gaaaagccat tgacaaaatc tctgcaacgt      300

ggagaagacc cccaatttga tcaggtcatc agctcaatga gctccctttc tgagtactgc      360

ctgccttcca ttctacgtac attatttgac tggtataaaa ggcaaaatgg cattgaggat      420

gaatcacatg aatacagacc aagaacaagc aataaatcaa aaagcgatga acaacagcga      480

gattatttaa tggaaagacg ggacctcgcc attgatttta ttttttcttt agtattaata      540

gaagttttga aacagattcc acttcatcct gtaatagaca gtttaataca tgatgttatt      600

aacttggctt tcaagcactt taaatacaaa gaagggtacc ttggtcccaa cactggcaat      660

atgcatattg tggcagacct gtatgcagaa gtcattggag tgttggcaca agccaaattc      720

cctgctgtaa agaagaaatt tatggcggag ctaaaagaat tacggcacaa agagcagaac      780

ccatatgtgg ttcaaagcat tatcagctta ataatgggca tgaaattctt tcgaattaag      840

atgtatccag tggaggattt tgaggcctct cttcagttta tgcaggaatg tgcacattac      900

ttcctcgagg tcaaagacaa agatatcaag catgccttgg ctgggctttt tgttgaaata      960

cttgttccag ttgctgctgc tgttaaaaat gaagtaaatg ttccctgcct tagaaatttt     1020

gtggaaagcc tgtatgacac cacgctggaa ctttcttctc gaaagaagca ttccttggcc     1080

ttgtaccccc tggtgacctg tttgctctgt gtcagtcaga agcagctgtt cctgaacagg     1140

tggcacattt tcctcaacaa ctgcttgtcc aaccttaaaa acaaagatcc caagatggct     1200

cgagttgcac tggaatctct ctacagatta ctttgggttt acatgattcg aattaaatgt     1260

gaaagcaaca cagctactca gagccgactt ataaccatca tcacaacact tttccccaaa     1320

gggtcccgcg gtgtggtacc aagggacatg cctctgaaca tctttgtgaa aatcatccag     1380

ttcattgccc aggaacgttt agattttgca atgaaagaaa tcattttcga ttttctttgt     1440

gtgggaaaac cagcaaaagc attcagtctc aacccagaga gaatgaacat tggtttacgg     1500

gcattcttgg tcatagctga tagcttgcag cagaaagatg gggaacctcc catgccggtt     1560

acaggagccg ttcttccttc aggaaacacg ttaagagtaa agaaaacata tttgagtaaa     1620

acactaactg aagaggaagc caaaatgata ggcatgtcct tatattactc tcaagtacga     1680

aaagctgtag acaacatttt aaggcacctt gataaagaag taggaaggtg tatgatgctg     1740

actaatgtac agatgttaaa caaagaaccg gaagacatga tcacgggtga gagaaagcca     1800

aaaatagatc ttttcaggac ctgtgttgct gctattcctc gactgcttcc tgatgggatg     1860

tcaaaacttg aacttattga cttactggct aggctctcta ttcatatgga tgatgaattg     1920

cgacatattg cacaaaattc tcttcagggt ttacttgttg acttctcaga ttggagggaa     1980

gatgtactat ttggctttac caacttcctg ctccgggaag taaatgatat gcatcacaca     2040

ctccttgatt cgtccctgaa gttgctgctg cagctgctca cccagtggaa actagtcatc     2100

cagacacaag gaaaagtcta tgaacaagcc aacaaaatca gaaattcaga gctcatcgca     2160

aatggctcca gtcacagaat tcagtcggaa cgaggtcccc actgcagtgt actccacgct     2220

gtagaaggtt ttgctctggt tttactctgc agtttccagg tggccacacg caaactgtcc     2280

gttttaatac tcaaggaaat tcgagcgttg tttattgccc tggggcagcc tgaggatgac     2340

gacaggccga tgattgatgt catggatcag ctaagttctt ccattctaga aagttttatt     2400

catgtagcag tttcggattc agcaacatta ccactcaccc acaatgtgga tctgcagtgg     2460

ttggtggaat ggaacgcagt cctggtcaat agccattatg atgtgaaaag cccttcccat     2520

gtctggatat ttgcacagtc tgtcaaagac ccctgggtcc tctgcctctt cagcttcctc     2580

cggcaggaga acttacccaa gcactgcccc acagccctca gctatgcctg gccttatgcc     2640

ttcactcggc tccagtcggt gatgcctctg gtggacccaa atagcccaat taatgccaag     2700

aaaaccagca ctgccggcag cggagacaac tatgttactt tgtggagaaa ttacctaatt     2760

ctttgttttg gagttgcaaa acccagtatt atgagcccag gacacttaag agcttccact     2820

ccagaaataa tggcgaccac acctgatggt acagtgagct acgataacaa ggccataggc     2880

accccatcgg tgggagttct gttaaagcag ttggtgcctt tgatgagact agagagcatt     2940

gagatcacag agtccttagt tttaggattt ggaagaacaa attcccttgt tttcagagaa     3000

ttggtagaag aacttcatcc attaatgaaa gaagctctgg aaagaagacc agagaacaag     3060

aaacgccgag aacggcgaga cttgttaagg ctacaactac ttcgaatttt tgaacttttg     3120

gctgatgctg gtgtaataag tgacagcaca aatggagccc tagagcggga tactttagcc     3180

ctgggagctt tgttcttaga atatgtggac ttgacccgca tgctcctaga agctgaaaat     3240

gacaaagaag ttgaaattct taaagatatc cgggcacatt ttagtgcaat ggtggccaac     3300

ttgattcagt gtgttccagt tcaccaccga agatttctct tcccccagca aagtctgagg     3360

caccaccttt tcatcttatt cagccagtgg gcaggaccct tcagcattat gttcactcct     3420

ctggatcgtt acagtgacag aaatcatcag attacaagat atcagtattg tgcattaaaa     3480

gcaatgtcag cagtactgtg ctgtggccct gtctttgaca atgtgggcct ttccccagat     3540

ggctacctat ataaatggct tgacaacatt ctggcttgtc aagatttacg agttcatcaa     3600

cttggctgcg aagttgttgt cttgctactg gaacttaatc ctgaccaaat aaatcttttt     3660

aactgggcaa ttgaccgatg ctacacaggt tcctaccaac ttgcatctgg ctgcttcaaa     3720

gccatagcaa ctgtgtgtgg aagcaggaac tatcccttcg acatagtgac attgttaaac     3780

cttgttctat tcaaggcctc tgacaccaac agagagattt atgaaatctc catgcagctc     3840

atgcagatcc ttgaagcaaa gctttttgta tactcaaaga aagtcgctga gcaaagaccg     3900

ggaagtattc tctatggaac acacggcccg ctgccacccc tctacagcgt gtcacttgcc     3960

ctcttgtcat gtgagctggc caggatgtac cctgagctca cactccccct cttctcagag     4020

gtaagccagc gattccccac aacacacccc aacgggcgcc agatcatgct tacctacctg     4080

ctgccctggc tgcacaacat cgagctggtg gacagcaggc tcctcctccc ggggtcgagc     4140

cccagcagcc cagaggacga agtcaaggac cgggaaggtg acgtgactgc ttctcacggg     4200

ctgagaggaa atggctgggg ctctccagaa gccacgtcac tggtcctgaa caacctcatg     4260

tacatgacgg ccaagtatgg agatgaagtt cctgggccag aaatggaaaa tgcttggaat     4320

gctttagcca acaatgagaa atggagcaac aacctgagga tcaccttgca gttcctgatt     4380

agcctctgtg gggtcagcag cgacacagtt ctcctaccct atattaaaaa agtggcaata     4440

tacttgtgcc gtaacaacac cattcaaacc atggaagagc ttctctttga gctgcagcag     4500

acagagcccg tgaaccccat cgtccagcat tgtgacaacc cgcccttcta ccgcttcacg     4560

gccagtagca aggcttccgc agcagcctca ggaaccacct ctagcagcaa tacagtggtt     4620

gctggccagg aaaatttccc agatgctgag gagaacaaga tattgaaaga atctgatgaa     4680

aggtttagta atgtcatcag agcccacact cgcctcgagt caagatacag caatagctct     4740

ggaggatcct acgatgaaga taaaaatgat ccaatttctc cctacacggg ctggttgctg     4800

actattacag agaccaagca gccgcagccc ttaccgatgc cttgtactgg aggatgctgg     4860

gcccccctgg ttgactatct cccggagacc atcactcccc gggggccact ccacaggtgc     4920

aatattgctg taatttttat gactgaaatg gtggtggatc acagtgtacg agaagactgg     4980

gcgcttcatc taccattatt acttcatgct gtcttcttag gtttagacca ctaccggcct     5040

gaagtctttg aacacagcaa aaaactgctt cttcacctct tgattgccct ctcttgcaac     5100

agcaatttcc attccattgc ttccgtgctc ctgcagaccc gagagatggg tgaagctaag     5160

actctaaccg tgcagccagc ctaccaacct gaatatctct atacaggtgg ctttgacttc     5220

ctgagagagg accagtcatc cccggtgcct gactcagggc ttagttcaag ctccacctcc     5280

tctagcatca gtctgggagg cagcagtgga aacctcccac agatgaccca ggaggtagaa     5340

gatgtggaca cagctgctga aacagatgag aaggcaaaca agctcattga gtttctcacg     5400

accagggcat ttggtccact ttggtgccat gaagacatca cacctaaaaa tcaaaattca     5460

aagagtgctg aacagctcac taattttcta cgtcacgttg tatctgtatt taaagattcc     5520

aaatcaggct tccatctgga gcaccagttg agtgaagttg cattgcagac agccctcgca     5580

agctcttcaa ggcactatgc tggtcggtcc ttccagatat tccgggccct caagcaacct     5640

ctgtcagcac atgccttatc tgaccttctc tcaagattgg tggaggtgat aggagaacat     5700

ggagatgaga ttcagggtta tgtaatggaa gcgctcctaa ccttggaggc ggctgtggat     5760

aacttgtctg actgcttgaa gaacagtgac ctcctaactg tattgtcccg ctcttcctca     5820

ccagatttaa gctccagcag taaactaaca gcaagcagaa agagcacagg acaactaaac     5880

atgaacccgg gaaccaccag cggcaacacc gcaactgccg aacggagccg gcatcaacga     5940

agcttctctg tgcccaagaa gtttggtgtc atcgaccgat cctctgaccc acctcgaagt     6000

gccacactgg acagaattca ggcttgtacc caacaaggcc tctcctcaaa aaccagaagc     6060

tcatcctcct tgaaggacag tctcacggac ccatcccaca taaaccatcc caccaacctg     6120

ctggccacca tattctgggt cacagtggcc ttgatggagt ctgattttga gtttgaatac     6180

ttaatggcct taaggctgtt gagcagacta ctggcacata tgccactcga taaggctgag     6240

aaccgagaaa agcttgagaa actccaggca cagctgaagt gggccgactt ctccgggctg     6300

cagcagctgc tgctgaaagg attcacatcc ctcaccacca cagacctgac cctgcagctc     6360

ttcagtctgc tgacaccagt gtccaaaata tccatggtgg atgcatccca cgctattggg     6420

tttccactga atgtcttgtg tctcctgcct cagctgattc agcattttga aaatcccaat     6480

cagttctgta aggatatagc cgaaaggatt gctcaggttt gtttagaaga gaagaacccc     6540

aaactttcaa atcttgcaca tgtcatgact ctttataaaa cgcacagcta cacgagggac     6600

tgtgccacgt gggtcaatgt ggtctgtcga taccttcatg aagcatatgc tgacattacc     6660

ttgaatatgg ttacctacct ggcagagctg ctggagaagg gcctccctag tgtgcagcag     6720

cccctgctcc aggtgatcta cagtcttctc agctacatgg acctttctgt cgttcctgtc     6780

aaacagttca atgtggaagt tctgaagaca attgaaaaat atgtgcaaag tgttcactgg     6840

agagaagctc tgaatatctt gaagctggta gtttctcggt cagccagcct tgttttacct     6900

tcataccagc acagtgacct ctcaaaaata gaaatacatc gagtgtggac tagtgcttcc     6960

aaggaattac ctgggaaaac cctggacttc cacttcgata tttcggagac tccaatcatc     7020

gggaggcggt atgatgagct gcagaattct tctgggcgtg atgggaagcc cagggccatg     7080

gccgtcaccc ggagcacatc ttccacttcc tcaggctcca actccaacgt ccttgttcca     7140

gtgagctgga aaaggcccca gtattctcag aagagaacaa aagagaagtt ggtacatgtc     7200

ctttctctgt gtggccaaga agtaggattg agcaaaaatc catcagtgat tttttcatcg     7260

tgtggggatc tggatctgct tgagcaccag acaagcttgg tatcttctga ggacggtgcc     7320

cgagagcagg agaacatgga tgacacaaac agcgagcagc agtttagagt cttcagagac     7380

ttcgacttcc tagatgtgga gctggaggat ggagagggtg agagtatgga caatttcaac     7440

tggggagtgc gcagacgttc tctggacagc ctggataagt gtgatatgca gattctggag     7500

gagcgccaac tgtcaggaag cactcctagc ctgaataaaa tgcaccatga ggactccgat     7560

gaatcatccg aggaggagga cctcacagcc agccagatcc tggagcactc agacctaatc     7620

atgactctct ccccctctga agagacgaat cccatggagc tgctcaccac agcctgtgac     7680

tcgacccctg cagaacctca ttcctttaac accagaatgt ccagctttga tgcttccttg     7740

cctgatatga ataatctgca gatttctgag ggttcaaagg ctgaagctgt tcgtgaggag     7800

gaggacacca ccgtgcatga ggatgatctt tctagttcca tcaatgaact cccagcagct     7860

tttgaatgca gcgacagctt tagcctggac atgactgagg gggaagaaaa aggcaatcgg     7920

gcactggacc agtttaccct ggcgagcttt ggagaaggtg acaggggagt ctctccccct     7980

ccctcgccct tcttctcagc catccttgcc gcctttcagc ccgcagcctg tgacgatgcc     8040

gaggaggcct ggcgcagcca catcaaccag cttatgtgtg actcagatgg ctcctgtgct     8100

gtgtatacat ttcatgtgtt ctcctccttg tttaagaata ttcagaaaag gttctgcttc     8160

ctaacctgtg atgcagccag ttaccttgga gataacctcc ggggaatcgg atccaaattt     8220

gtcagctctt cccagatgct cacctcctgc tctgaatgtc ctacactttt tgtggatgcc     8280

gagactctcc tttcatgtgg acttctggac aagctcaagt tcagtgtgtt agaactgcaa     8340

gaatatttgg atacctacaa caacaggaaa gaggccacac tctcttggct tgcaaattgt     8400

aaggcaacat ttgcaggggg atcaagagat ggagtaatta cctgtcaacc aggggactcc     8460

gaagaaaagc aattggaact gtgtcagaga ttatataagc tacacttcca gctgctattg     8520

ctttttcagt cctactgtaa gctcatcggc caggtgcacg aagttagctc catgccagag     8580

ctgctgaata tgtccaggga actgagtgac ctaaagaaac acctgaagga agccagtgca     8640

gtcattgcag ctgaccctct ctattcagac ggcgcgtggt ccgagcccac cttcacgtcc     8700

actgaagcag ccatccagtc catgctggag tgcctgaaga acaacgaact cggcaaagct     8760

ttgcggcaga tcagggagtg cagaagtctg tggcccaatg acatctttgg aagcagttct     8820

gatgatgagg tccagacact actgaatatt tatttccgtc accaaactct gggacagacg     8880

ggtacttatg ccctggtggg gtctaaccag agcctgaccg agatctgcac caagctgatg     8940

gagctgaaca tggagatccg ggacatgatc cgcagggccc agagttaccg agtcctcact     9000

acttttcttc cagactccag tgtttctggc actagtctct ga                        9042


<210>  291
<211>  2490
<212>  DNA
<213>  Homo sapiens;

<400>  291
atggcgaaat ataacacggg gggcaacccg acagaggatg tctcagtcaa tagccgaccc       60

ttcagagtca cagggccaaa ctcatcttca ggaatacaag caagaaagaa cttattcaac      120

aaccaaggaa atgccagccc tcctgcagga cccagcaatg tacctaagtt tgggtcccca      180

aagccacctg tggcagtcaa accttcttct gaggaaaagc ctgacaagga acccaagccc      240

ccgtttctaa agcccactgg agcaggccaa agattcggaa caccagccag cttgaccacc      300

agagaccccg aggcgaaagt gggatttctg aaacctgtag gccccaagcc catcaacttg      360

cccaaagaag attccaaacc tacatttccc tggcctcctg gaaacaagcc atctcttcac      420

agtgtaaacc aagaccatga cttaaagcca ctaggcccga aatctgggcc tactcctcca      480

acctcagaaa atgaacagaa gcaagcgttt cccaaattga ctggggttaa agggaaattt      540

atgtcagcat cacaagatct tgaacccaag cccctcttcc ccaaacccgc ctttggccag      600

aagccgcccc taagtaccga gaactcccat gaagacgaaa gccccatgaa gaatgtgtct      660

tcatcaaaag ggtccccagc tcccctggga gtcaggtcca aaagcggccc tttaaaacca      720

gcaagggaag actcagaaaa taaagaccat gcaggggaga tttcaagttt gccctttcct      780

ggagtggttt tgaaacctgc tgcgagcagg ggaggcccag gtctctccaa aaatggtgaa      840

gaaaaaaagg aagataggaa gatagatgct gctaagaaca ccttccagag caaaataaat      900

caggaagagt tggcctcagg gactcctcct gccaggttcc ctaaggcccc ttctaagctg      960

acagtggggg ggccatgggg ccaaagtcag gaaaaggaaa agggagacaa gaattcagcc     1020

accccgaaac agaagccatt gcctcccttg tttaccttgg gtccacctcc accaaaaccc     1080

aacagaccac caaatgttga cctgacgaaa ttccacaaaa cctcttctgg aaacagtact     1140

agcaaaggcc agacgtctta ctcaacaact tccctgccac cacctccacc atcccatccg     1200

gccagccaac caccattgcc agcatctcac ccatcacaac caccagtccc aagcctacct     1260

cccagaaaca ttaaacctcc gtttgaccta aaaagccctg tcaatgaaga caatcaagat     1320

ggtgtcacgc actctgatgg tgctggaaat ctagatgagg aacaagacag tgaaggagaa     1380

acatatgaag acatagaagc atccaaagaa agagagaaga aaagggaaaa ggaagaaaag     1440

aagaggttag agctggagaa aaaggaacag aaagagaaag aaaagaaaga acaagaaata     1500

aagaagaaat ttaaactaac aggccctatt caagtcatcc atcttgcaaa agcttgttgt     1560

gatgtcaaag gaggaaagaa tgaactgagc ttcaagcaag gagagcaaat tgaaatcatc     1620

cgcatcacag acaacccaga aggaaaatgg ttgggcagaa cagcaagggg ttcatatggc     1680

tatattaaaa caactgctgt agagattgac tatgattctt tgaaactgaa aaaagactct     1740

cttggtgccc cttcaagacc tattgaagat gaccaagaag tatatgatga tgttgcagag     1800

caggatgata ttagcagcca cagtcagagt ggaagtggag ggatattccc tccaccacca     1860

gatgatgaca tttatgatgg gattgaagag gaagatgctg atgatggctc cacactacag     1920

gttcaagaga agagtaatac gtggtcctgg gggattttga agatgttaaa gggaaaagat     1980

gacagaaaga aaagtatacg agagaaacct aaagtctctg actcagacaa taatgaaggt     2040

tcatctttcc ctgctcctcc taaacaattg gacatgggag atgaagttta cgatgatgtg     2100

gatacctctg atttccctgt ttcatcagca gagatgagtc aaggaactaa tgttggaaaa     2160

gctaagacag aagaaaagga ccttaagaag ctaaaaaagc aggaaaaaga agaaaaagac     2220

ttcaggaaaa aatttaaata tgatggtgaa attagagtcc tatattcaac taaagttaca     2280

acttccataa cttctaaaaa gtggggaacc agagatctac aggtaaaacc tggtgaatct     2340

ctagaagtta tacaaaccac agatgacaca aaagttctct gcagaaatga agaagggaaa     2400

tatggttatg tccttcggag ttacctagcg gacaatgatg gagagatcta tgatgatatt     2460

gctgatggct gcatctatga caatgactag                                      2490


<210>  292
<211>  354
<212>  DNA
<213>  Homo sapiens;

<400>  292
atgaagttcg tgtacaaaga agagcatccg ttcgagaagc gccgctctga gggcgagaag       60

atccgaaaga aatacccgga ccgggtgccg gtgatagtag aaaaggctcc caaagctcgg      120

ataggagacc tggacaaaaa gaaatacctg gtgccttctg atctcacagt tggtcagttc      180

tacttcttga tccggaagcg aattcatctc cgagctgagg atgccttgtt tttctttgtc      240

aacaatgtca ttccacccac cagtgccaca atgggtcagc tgtaccagga acaccatgaa      300

gaagacttct ttctctacat tgcctacagt gacgaaagtg tctacggtct gtga            354


<210>  293
<211>  5055
<212>  DNA
<213>  Homo sapiens;

<400>  293
atggaggatc ttgttcaaga tggggtggct tcaccagcta cccctgggac cgggaaatct       60

aagctggaaa cattgcccaa agaagacctc atcaagtttg ccaagaaaca gatgatgcta      120

atacagaaag ctaaatcaag gtgtacagaa ttggagaaag aaattgaaga actcagatca      180

aaacctgtta ctgaaggaac tggtgatatt attaaggcat taactgaacg tctggatgct      240

cttcttctgg aaaaagcaga gactgagcaa cagtgtcttt ctctgaaaaa ggaaaatata      300

aaaatgaagc aagaggttga ggattctgta acaaagatgg gagatgcaca taaggagttg      360

gaacaatcac atataaacta tgtgaaagaa attgaaaatt tgaaaaatga gttgatggca      420

gtacgttcca aatacagtga agacaaagct aacttacaaa agcagctgga agaagcaatg      480

aatacgcaat tagaactttc agaacaactt aaatttcaga acaactctga agataatgtt      540

aaaaaactac aagaagagat tgagaaaatt aggccaggct ttgaggagca aattttatat      600

ctgcaaaagc aattagacgc taccactgat gaaaagaagg aaacagttac tcaactccaa      660

aatatcattg aggctaattc tcagcattac caaaaaaata ttaatagttt gcaggaagag      720

cttttacagt tgaaagctat acaccaagaa gaggtgaaag agttgatgtg ccagattgaa      780

gcatcagcta aggaacatga agcagagata aataagttga acgagctaaa agagaactta      840

gtaaaacaat gtgaggcaag tgaaaagaac atccagaaga aatatgaatg tgagttagaa      900

aatttaagga aagccacctc aaatgcaaac caagacaatc agatatgttc tattctcttg      960

caagaaaata catttgtaga acaagtagta aatgaaaaag tcaaacactt agaagatacc     1020

ttaaaagaac ttgaatctca acacagtatc ttaaaagatg aggtaactta tatgaataat     1080

cttaagttaa aacttgaaat ggatgctcaa catataaagg atgagttttt tcatgaacgg     1140

gaagacttag agtttaaaat taatgaatta ttactagcta aagaagaaca gggctgtgta     1200

attgaaaaat taaaatctga gctagcaggt ttaaataaac agttttgcta tactgtagaa     1260

cagcataaca gagaagtaca gagtcttaag gaacaacatc aaaaagaaat atcagaacta     1320

aatgagacat ttttgtcaga ttcagaaaaa gaaaaattaa cattaatgtt tgaaatacag     1380

ggtcttaagg aacagtgtga aaacctacag caagaaaagc aagaagcaat tttaaattat     1440

gagagtttac gagagattat ggaaatttta caaacagaac tgggggaatc tgctggaaaa     1500

ataagtcaag agttcgaatc aatgaagcaa cagcaagcat ctgatgttca tgaactgcag     1560

cagaagctca gaactgcttt tactgaaaaa gatgcccttc tcgaaactgt gaatcgcctc     1620

cagggagaaa atgaaaagtt actatctcaa caagaattgg taccagaact tgaaaatacc     1680

ataaagaacc ttcaagaaaa gaatggagta tacttactta gtctcagtca aagagatacc     1740

atgttaaaag aattagaagg aaagataaat tctcttactg aggaaaaaga tgattttata     1800

aataaactga aaaattccca tgaagaaatg gataatttcc ataagaaatg tgaaagggaa     1860

gaaagattga ttcttgaact tgggaagaaa gtagagcaaa caatccagta caacagtgaa     1920

ctagaacaaa aggtaaatga attaacagga ggactagagg agactttaaa agaaaaggat     1980

caaaatgacc aaaaactaga aaaacttatg gttcaaatga aagttctctc tgaagacaaa     2040

gaagtattgt cagctgaagt gaagtctctt tatgaggaaa acaataaact cagttcagaa     2100

aaaaaacagt tgagtaggga tttggaggtt tttttgtctc aaaaagaaga tgttatcctt     2160

aaagaacata ttactcaatt agaaaagaaa cttcagttaa tggttgaaga gcaagataat     2220

ttaaataaac tgcttgaaaa tgagcaagtt cagaagttat ttgttaaaac tcagttgtat     2280

ggttttctta aagaaatggg atcagaagtt tcagaagaca gtgaagagaa agatgttgtt     2340

aatgtcctac aggcagtcgg tgaatccttg gcaaaaataa atgaggaaaa atgcaacctg     2400

gcttttcagc gtgatgaaaa agtattagag ttagaaaaag agattaagtg ccttcaagaa     2460

gagagtgtag ttcagtgtga agaacttaag tctttattga gagactatga gcaagagaaa     2520

gttctcttaa ggaaagagtt agaagaaata cagtcagaaa aagaggccct gcagtctgat     2580

cttctagaaa tgaagaatgc taatgaaaaa acaaggcttg aaaatcagaa tcttttaatt     2640

caagttgaag aagtatctca aacatgtagc aaaagtgaaa tccataatga aaaagaaaaa     2700

tgttttataa aggaacatga aaacctaaag ccactactag aacaaaaaga attacgagat     2760

aggagagcag agttgatact attaaaggat tccttagcaa aatcaccttc tgtaaaaaat     2820

gatcctctgt cttcagtaaa agagttggaa gaaaaaatag aaaatctgga aaaagaatgc     2880

aaagaaaagg aggagaaaat aaataagata aaattagttg ccgtaaaggc aaagaaagaa     2940

ctagattcca gcagaaaaga gacccagact gtgaaggaag aacttgaatc tcttcgatca     3000

gaaaaggacc agttatctgc ttccatgaga gatctcattc aaggagcaga aagctataag     3060

aatcttttat tagaatatga aaagcagtca gagcaactgg atgtggaaaa agaacgtgct     3120

aataattttg agcatcgtat tgaagacctt acaagacaat taagaaattc gactttgcag     3180

tgtgaaacaa taaattctga taatgaagat ctcctggctc gtattgagac attacagtct     3240

aatgccaaat tattagaagt acagatttta gaagtccaga gagccaaagc aatggtagac     3300

aaagaattag aagctgaaaa acttcagaaa gaacagaaga taaaggaaca tgccactact     3360

gtaaatgaac ttgaagaact tcaggtacaa cttcaaaagc aaaagaaaca gcttcagaaa     3420

accatgcaag aattagagct ggttaaaaag gatgcccaac aaaccacatt gatgaatatg     3480

gaaatagctg attatgaacg tttgatgaaa gaactaaatc aaaagttaac taataaaaac     3540

aacaagatag aagatttgga gcaagaaata aaaattcaaa aacagaaaca agaaacccta     3600

caagaagaaa taacttcatt acagtcttca gtacaacaat atgaagaaaa aaacaccaaa     3660

atcaagcaat tgcttgtgaa aaccaaaaag gaactggcag attcaaagca agcagaaact     3720

gatcacttaa tacttcaagc atctttaaaa ggtgagctgg aggcaagcca gcagcaagta     3780

gaagtctata aaatacagct ggctgaaata acatcagaga agcacaaaat ccacgagcac     3840

ctgaaaacct ctgcggaaca gcaccagcgt acgctaagtg cataccagca gagagtgaca     3900

gcactacagg aagagtgccg tgctgccaag gcagaacaag ctactgtaac ctctgaattc     3960

gagagctaca aagtccgagt tcataatgtt ctaaaacaac agaaaaataa atctatgtct     4020

caggctgaaa ctgagggcgc taaacaagaa agggaacatc tggaaatgct gattgaccag     4080

ctaaaaatca aattacaaga tagccaaaat aacttacaga ttaatgtatc tgaacttcaa     4140

acattgcagt ctgaacatga tacactgcta gaaaggcaca acaagatgct gcaggaaact     4200

gtgtccaaag aggcggaact ccgggaaaaa ttgtgttcaa tacagtcaga gaacatgatg     4260

atgaaatctg aacatacaca gactgtgagt cagctaacat cccagaacga ggtccttcga     4320

aatagcttcc gagatcaagt gcgacatttg caggaagaac acagaaagac agtggagaca     4380

ttacagcagc agctctccaa gatggaagca cagctcttcc agcttaagaa tgaaccgacc     4440

acaagaagcc cagtttcctc tcaacaatct ttgaagaacc ttcgagaaag gagaaacaca     4500

gacctcccgc ttctagacat gcacactgta acccgggaag agggagaagg catggagaca     4560

actgatacgg agtctgtgtc ttccgccagc acatacacac agtctttaga gcagctgctt     4620

aactctcccg aaactaaact tgagcctcca ttatggcatg ctgaatttac caaagaagaa     4680

ttggttcaga agctcagttc caccacaaaa agtgcagatc acttaaacgg cctgcttcgg     4740

gaaacagaag caaccaatgc aattcttatg gagcaaatta agcttctcaa aagtgaaata     4800

agaagattgg aaaggaatca agagcgagag aagtctgcag ctaacctgga atacttgaag     4860

aacgtcttgc tgcagttcat tttcttgaaa ccaggtagtg aaagagagag acttcttcct     4920

gttataaata cgatgttgca gctcagccct gaagaaaagg gaaaacttgc tgcggttgct     4980

caaggtgagg aagaaaatgc ttcccgttct tctggatggg catcctatct tcatagttgg     5040

tctggacttc gatag                                                      5055


<210>  294
<211>  2913
<212>  DNA
<213>  Homo sapiens;

<400>  294
atggacgcag cagagccggg actcccccca ggtcctgagg gcaggaagag gtacagtgac       60

atcttccgga gcctggacaa cctcgaaatc tcactgggga acgtgaccct tgagatgctg      120

gctggagacc ctctactctc agaagaccca gaacctgaca agacccctac agccactgtt      180

accaacgaag ccagctgttg gagcggcccc tccccagagg gtcctgtacc cctcacaggg      240

gaggaactgg acttgcggct cattcggaca aaggggggtg tggacgcagc cctggaatat      300

gccaagacct ggagccgcta tgccaaggaa ctgcttgcct ggactgaaaa gagagccagc      360

tatgagctgg agtttgctaa gagcaccatg aagatcgctg aagctggcaa ggtgtccatt      420

caacagcaga gccacatgcc tctgcagtac atctacaccc tgtttctgga gcacgatctc      480

agcctgggaa ccctggccat ggagacagtg gcccagcaga aaagagacta ctaccagccc      540

ctcgccgcca aacggactga gattgagaag tggcggaagg agttcaagga gcagtggatg      600

aaggagcaga agcggatgaa tgaggcggtg caggcactgc ggcgcgccca gctgcagtat      660

gtgcaacgca gcgaggacct gcgggcacgc tcccaggggt cccctgagga ctcggccccc      720

caggcctcgc cgggacctag caagcagcag gagcggcggc ggcgctcgcg agaggaggcc      780

caggccaagg cgcaggaggc cgaggcgctg taccaggcct gtgtccgcga ggccaacgcg      840

cggcagcagg acctggagat cgccaagcag cgaatcgtgt cgcacgtgcg caagctggtg      900

tttcaggggg atgaagtgct gaggcgggtg acgctgagtc tcttcgggct gcggggggcg      960

caggcagagc gtggcccccg cgccttcgcc gccctggccg agtgctgtgc gccctttgag     1020

ccgggccagc gctaccagga gtttgtacgg gcgctgcggc ccgaggcccc gccgcccccg     1080

ccgcccgcct tctccttcca ggagttcctt ccctccttga acagctcccc tctggacatc     1140

agaaagaagc tctctgggcc tcttcctcca aggctggatg agaattcagc tgagccaggc     1200

ccttgggagg atccgggcac aggctggcgc tggcaaggga ctccaggccc cactccgggc     1260

agcgatgtgg acagcgtggg tggcggcagc gagtctcggt ccctggactc acccacttcc     1320

agcccaggcg ctggcacgag gcagctggtg aaggcttcgt ccacaggcac tgagtcctca     1380

gatgactttg aggagcgaga ccctgacctg ggagacgggc tggagaatgg gctgggcagc     1440

cccttcggga agtggacact gtccagcgcg gctcagaccc accagctgcg gcgactgcgg     1500

ggcccagcca agtgccgcga gtgcgaagcc ttcatggtca gcgggacgga gtgtgaggag     1560

tgctttctga cctgccacaa gcgctgcctg gagactctcc tgatcctctg tggacacagg     1620

cggctcccag cccggacacc cctttttggg gttgacttcc tgcagctacc cagggacttc     1680

ccggaggagg taccctttgt ggtcacgaag tgcacggctg agatagaaca ccgtgccctg     1740

gatgtgcagg gcatttaccg ggtcagcggg tcccgggtcc gtgtggagcg gctgtgccag     1800

gctttcgaga atggccgagc gttggtggag ctgtcgggga actcgcctca tgacgtctcg     1860

agtgtcctca agcgatttct tcaggagctc accgagcccg tgatcccctt ccacctctac     1920

gacgccttca tctctctggc taagaccttg catgcagacc ctggggacga ccctgggacc     1980

cccagcccca gccctgaggt tatccgctcg ctgaagaccc tcttggtaca gctgcctgac     2040

tctaactaca acaccctgcg gcacctggtg gcccatctgt tcagggtggc tgcacgattt     2100

atggaaaaca agatgtctgc caacaacctg ggcattgtgt ttgggccgac actgctgcgg     2160

ccgccggacg gcccgcgggc agccagcgcc atccctgtca cctgcctgct ggactctggg     2220

catcaggccc agcttgtgga gttcctcatc gtgcactacg agcagatctt tgggatggat     2280

gagctccccc aggccactga gcccccgccc caagactcca gcccagcccc tgggcccctc     2340

acaaccagct cccaaccgcc acccccgcac cttgacccag actcccagcc cccagtccta     2400

gcctcagacc ccggcccaga cccccagcac cacagtaccc tggagcagca tcccacggcc     2460

acacctaccg agattccaac tccacagagt gaccagagag aggacgtggc tgaagacacc     2520

aaagatgggg gaggggaagt gtccagccaa ggcccagagg actcactcct ggggacacag     2580

tctcgtggcc acttcagccg ccagccagtg aagtatcccc ggggcggtgt gaggcctgta     2640

acccaccagc tgtccagtct ggccctggtg gcttccaagc tgtgcgagga gacccccatc     2700

acatcagtgc ccagagggag tttgcggggg cgggggccca gccctgcagc tgcctcccct     2760

gagggcagcc ccctgcgccg caccccgctg cccaagcatt ttgagattac ccaggagaca     2820

gcccggctac tctcgaaatt ggacagcgag gctgtgccca gggccacctg ctgcccggac     2880

gtccagcctg aggaagccga ggaccatctc tga                                  2913


<210>  295
<211>  1146
<212>  DNA
<213>  Homo sapiens;

<400>  295
atgtccgggg tggtgcggac cctcagccgc tgcctgctgc cggccgaggc cggcggggcc       60

cgcgagcgca gggcgggcag cggcgcgcgc gacgcggagc gcgaggcccg gaggcgtagc      120

cgcgacatcg acgcgctgct ggcccgcgag cggcgcgcgg tccggcgcct ggtgaagatc      180

ctgctgctgg gcgcgggcga gagcggcaag tccacgttcc tcaagcagat gcgcatcatc      240

cacggccgcg agttcgacca gaaggcgctg ctggagttcc gcgacaccat cttcgacaac      300

atcctcaagg gctcaagggt tcttgttgat gcacgagata agcttggcat tccttggcag      360

tattctgaaa atgagaagca tgggatgttc ctgatggcct tcgagaacaa ggcggggctg      420

cctgtggagc cggccacctt ccagctgtac gtcccggccc tgagcgcact ctggagggat      480

tctggcatca gggaggcttt cagccggaga agcgagtttc agctggggga gtcggtgaag      540

tacttcctgg acaacttgga ccggatcggc cagctgaatt actttcctag taagcaagat      600

atcctgctgg ctaggaaagc caccaaggga attgtggagc atgacttcgt tattaagaag      660

atccccttta agatggtgga tgtgggcggc cagcggtccc agcgccagaa gtggttccag      720

tgcttcgacg ggatcacgtc catcctgttc atggtctcct ccagcgagta cgaccaggtc      780

ctcatggagg acaggcgcac caaccggctg gtggagtcca tgaacatctt cgagaccatc      840

gtcaacaaca agctcttctt caacgtctcc atcattctct tcctcaacaa gatggacctc      900

ctggtggaga aggtgaagac cgtgagcatc aagaagcact tcccggactt caggggcgac      960

ccgcacaggc tggaggacgt ccagcgctac ctggtccagt gcttcgacag gaagagacgg     1020

aaccgcagca agccactctt ccaccacttc accaccgcca tcgacaccga gaacgtccgc     1080

ttcgtgttcc atgctgtgaa agacaccatc ctgcaggaga acctgaagga catcatgctg     1140

cagtga                                                                1146


<210>  296
<211>  1080
<212>  DNA
<213>  Homo sapiens;

<400>  296
atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg       60

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc      120

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga      180

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat      240

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca      300

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag      360

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga      420

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat      480

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt      540

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt      600

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt      660

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg      720

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca      780

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag      840

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga      900

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt      960

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc     1020

tttgctgccg tcaaggacac catcctccag ttgaacctga aggagtacaa tctggtctaa     1080


<210>  297
<211>  414
<212>  DNA
<213>  Homo sapiens;

<400>  297
atgaggccgc agcaggcgcc ggtgtccgga aaggtgttca ttcagcgaga ctacagcagt       60

ggcacacgct gccagttcca gaccaagttc cctgcggagc tggagaaccg gattgatagg      120

cagcagtttg aagaaacagt tcgaactcta aataaccttt atgcagaagc agagaagctc      180

ggcggccagt catatctcga aggttgtttg gcttgtttaa cagcatatac catcttccta      240

tgcatggaaa ctcattatga gaaggttctg aagaaagtct ccaaatacat tcaagagcag      300

aatgagaaga tctatgctcc acaaggcctc ctcctgacag accctattga gcgaggactg      360

cgagttattg aaattaccat ttatgaagac agaggcatga gcagtggaag ataa            414


<210>  298
<211>  1425
<212>  DNA
<213>  Homo sapiens;

<400>  298
atggcgcagc atgattttgt tcctgcttgg ctaaatttct caacaccaca gtcagctaag       60

tcacctactg ccaccttcga aaaacacgga gagcacctac ccagaggaga aggtagattt      120

ggagtaagcc gccgtcgaca taattcctct gatggttttt ttaacaatgg tcccctacga      180

actgcaggag attcttggca ccagccctcc ctgttccgcc atgattctgt ggactctggt      240

gtctctaagg gagcatatgc tggaatcaca gggaacccat ctggttggca tagctcttcc      300

cgaggtcatg atggcatgag ccaacgtagt ggaggtggca cagggaacca tcgccattgg      360

aatggcagct tccactcccg gaaagggtgt gcttttcagg aaaagccacc tatggagatt      420

agggaagaaa agaaagaaga caaggtggaa aagttgcagt ttgaagagga ggactttcct      480

tccttgaatc cagaagctgg caaacagcat cagccatgca gacctattgg gacaccttct      540

ggagtatggg aaaacccgcc tagtgccaag caaccctcca agatgctagt tatcaaaaaa      600

gtttccaaag aggatcctgc tgctgccttc tctgctgcat tcacctcacc aggatctcac      660

catgcaaatg ggaacaaatt gtcatccgtg gttccaagtg tctataagaa cctggttcct      720

aagcctgtac cacctccttc caagcctaat gcatggaaag ctaacaggat ggagcacaag      780

tcaggatccc tttcctctag ccgggagtct gcttttacca gtccaatctc tgttaccaaa      840

ccagtggtac tggctagtgg tgcagctctg agttctccca aagagagtcc ctccagcacc      900

acccctccaa ttgagatcag ctcctctcgt ctgaccaagt tgacccgccg aaccaccgac      960

aggaagagtg agttcctgaa aactctgaag gatgaccgga atggagactt ctcagagaat     1020

agagactgtg acaagctgga agatttggag gacaacagca cacctgaacc aaaggaaaat     1080

ggggaggaag gctgtcatca aaatggtctt gccctccctg tagtggaaga aggggaggtt     1140

ctctcacact ctctagaagc agagcacagg ttattgaaag ctatgggttg gcaggaatat     1200

cctgaaaatg atgagaattg ccttcccctc acagaggatg agctcaaaga gttccacatg     1260

aagacagagc agctgagaag aaatggcttt ggaaagaatg gcttcttgca gagccgcagt     1320

tccagtctgt tctccccttg gagaagcact tgcaaagcag agtttgagga ctcagacacc     1380

gaaaccagta gcagtgaaac atcagatgac gatgcctgga agtag                     1425


<210>  299
<211>  1650
<212>  DNA
<213>  Homo sapiens;

<400>  299
atggcgacgc ccaggggcct gggggccctg ctcctgctcc tcctgctccc gacctcaggt       60

caggaaaagc ccaccgaagg gccaagaaac acctgcctgg ggagcaacaa catgtacgac      120

atcttcaact tgaatgacaa ggctttgtgc ttcaccaagt gcaggcagtc gggcagcgac      180

tcctgcaatg tggaaaactt gcagagatac tggctaaact acgaggccca tctgatgaag      240

gaaggtttga cgcagaaggt gaacacgcct ttcctgaagg ctttggtcca gaacctcagc      300

accaacactg cagaagactt ctatttctct ctggagccct ctcaggttcc gaggcaggtg      360

atgaaggacg aggacaagcc ccctgacaga gtgcgacttc ccaagagcct ttttcgatcc      420

ctgccaggca acaggtctgt ggtccgcttg gccgtcacca ttctggacat tggtccaggg      480

actctcttca agggcccccg gctcggcctg ggagatggca gcggcgtgtt gaacaatcgc      540

ctggtgggtt tgagtgtggg acaaatgcat gtcaccaagc tggctgagcc tctggagatc      600

gtcttctctc accagcgacc gccccctaac atgaccctca cctgtgtatt ctgggatgtg      660

actaaaggga ccactggaga ctggtcttct gagggctgct ccacggaggt cagacctgag      720

gggaccgtgt gctgctgtga ccacctgacc tttttcgccc tgctcctgag acccaccttg      780

gaccagtcca cggtgcatat cctcacacgc atctcccagg cgggctgtgg ggtctccatg      840

atcttcctgg ccttcaccat tattctttat gcctttctga ggctttcccg ggagaggttc      900

aagtcagaag atgccccaaa gatccacgtg gccctgggtg gcagcctgtt cctcctgaat      960

ctggccttct tggtcaatgt ggggagtggc tcaaaggggt ctgatgctgc ctgctgggcc     1020

cggggggctg tcttccacta cttcctgctc tgtgccttca cctggatggg ccttgaagcc     1080

ttccacctct acctgctcgc tgtcagggtc ttcaacacct acttcgggca ctacttcctg     1140

aagctgagcc tggtgggctg gggcctgccc gccctgatgg tcatcggcac tgggagtgcc     1200

aacagctacg gcctctacac catccgtgat agggagaacc gcacctctct ggagctatgc     1260

tggttccgtg aagggacaac catgtacgcc ctctatatca ccgtccacgg ctacttcctc     1320

atcaccttcc tctttggcat ggtggtcctg gccctggtgg tctggaagat cttcaccctg     1380

tcccgtgcta cagcggtcaa ggagcggggg aagaaccgga agaaggtgct caccctgctg     1440

ggcctctcga gcctggtggg tgtgacatgg gggttggcca tcttcacccc gttgggcctc     1500

tccaccgtct acatctttgc acttttcaac tccttgcaag gtgtcttcat ctgctgctgg     1560

ttcaccatcc tttacctccc aagtcagagc accacagtct cctcctctac tgcaagattg     1620

gaccaggccc actccgcatc tcaagaatag                                      1650


<210>  300
<211>  984
<212>  DNA
<213>  Homo sapiens;

<400>  300
atgcccgcac tcctggagcg ccccaagctt tccaacgcca tggccagggc gctgcaccgg       60

cacattatga tggagcggga gcgcaagcgg caggaggaag aagaggtgga taagatgatg      120

gaacagaaga tgaaggaaga acaggagaga aggaagaaaa aggagatgga agagagaatg      180

tcattagagg agaccaagga acaaattctg aagttggagg agaagctttt ggctctacag      240

gaagagaagc accagctttt cctgcagctc aagaaagttt tacatgagga agaaaaacgg      300

aggcgaaagg aacagagtga cctgaccacc ctaacatcag ctgcatacca gcagagcctg      360

actgttcaca caggaactca tctcctcagc atgcagggga gccctggagg acacaatcgc      420

ccaggcaccc tcatggcagc tgacagagcc aaacaaatgt ttggacccca agtgcttacg      480

acccggcact acgtgggctc agcagctgct tttgcaggga caccagagca tggacaattc      540

caaggcagtc ctggtggtgc ctatgggact gctcagcccc cacctcacta tgggcccaca      600

cagccagctt atagtcctag tcagcagctc agagctcctt cggcattccc tgcagtgcag      660

tacctatctc agccacagcc acagccctat gctgtgcatg gccactttca gcccactcag      720

acaggtttcc tccagcctgg tggtgccctg tccttgcaaa agcagatgga acatgctaac      780

cagcagactg gcttctccga ctcatcctct ctgcgcccca tgcaccccca ggctctgcat      840

ccagcccctg gactccttgc ttccccccag ctccctgtgc agatgcagcc agcaggaaag      900

tcgggctttg cagctaccag ccaacctggc cctcggctcc ccttcatcca acacagccag      960

aacccgcgat tctaccacaa gtga                                             984


<210>  301
<211>  483
<212>  DNA
<213>  Homo sapiens;

<400>  301
atggaggctg agagacccca ggaagaagag gatggtgagc agggcccccc tcaggatgag       60

gaaggctggc cccctccaaa ctccaccact cggccttggc gatctgctcc tccatcccct      120

cctcctccag ggacccgcca cacagccctg ggaccccgct cggcctccct gctctccctg      180

cagactgaac tccttctgga cctggtggct gaagcccagt cccgccgcct ggaggagcag      240

agggccacct tctacacccc ccaaaacccc tcaagcctag cccctgcccc actccgtcct      300

ctcgaggaca gagaacagct ttacagcact atcctcagtc accagtgcca gcggatggaa      360

gcccagcggt cagagcctcc cctccctcca ggggggcaag agctcctgga gttgctgctg      420

agagttcagg gtgggggtcg aatggaggag caaaggtccc ggccccccac acacacctgc      480

tga                                                                    483


<210>  302
<211>  654
<212>  DNA
<213>  Homo sapiens;

<400>  302
atggaagcca tcgccaaata tgacttcaaa gctactgcag acgacgagct gagcttcaaa       60

aggggggaca tcctcaaggt tttgaacgaa gaatgtgatc agaactggta caaggcagag      120

cttaatggaa aagacggctt cattcccaag aactacatag aaatgaaacc acatccgtgg      180

ttttttggca aaatccccag agccaaggca gaagaaatgc ttagcaaaca gcggcacgat      240

ggggcctttc ttatccgaga gagtgagagc gctcctgggg acttctccct ctctgtcaag      300

tttggaaacg atgtgcagca cttcaaggtg ctccgagatg gagccgggaa gtacttcctc      360

tgggtggtga agttcaattc tttgaatgag ctggtggatt atcacagatc tacatctgtc      420

tccagaaacc agcagatatt cctgcgggac atagaacagg tgccacagca gccgacatac      480

gtccaggccc tctttgactt tgatccccag gaggatggag agctgggctt ccgccgggga      540

gattttatcc atgtcatgga taactcagac cccaactggt ggaaaggagc ttgccacggg      600

cagaccggca tgtttccccg caattatgtc acccccgtga accggaacgt ctaa            654


<210>  303
<211>  1302
<212>  DNA
<213>  Homo sapiens;

<400>  303
atgtcagggc ggcccagaac cacctccttt gcggagagct gcaagccggt gcagcagcct       60

tcagcttttg gcagcatgaa agttagcaga gacaaggacg gcagcaaggt gacaacagtg      120

gtggcaactc ctgggcaggg tccagacagg ccacaagaag tcagctatac agacactaaa      180

gtgattggaa atggatcatt tggtgtggta tatcaagcca aactttgtga ttcaggagaa      240

ctggtcgcca tcaagaaagt attgcaggac aagagattta agaatcgaga gctccagatc      300

atgagaaagc tagatcactg taacatagtc cgattgcgtt atttcttcta ctccagtggt      360

gagaagaaag atgaggtcta tcttaatctg gtgctggact atgttccgga aacagtatac      420

agagttgcca gacactatag tcgagccaaa cagacgctcc ctgtgattta tgtcaagttg      480

tatatgtatc agctgttccg aagtttagcc tatatccatt cctttggaat ctgccatcgg      540

gatattaaac cgcagaacct cttgttggat cctgatactg ctgtattaaa actctgtgac      600

tttggaagtg caaagcagct ggtccgagga gaacccaatg tttcgtatat ctgttctcgg      660

tactataggg caccagagtt gatctttgga gccactgatt atacctctag tatagatgta      720

tggtctgctg gctgtgtgtt ggctgagctg ttactaggac aaccaatatt tccaggggat      780

agtggtgtgg atcagttggt agaaataatc aaggtcctgg gaactccaac aagggagcaa      840

atcagagaaa tgaacccaaa ctacacagaa tttaaattcc ctcaaattaa ggcacatcct      900

tggactaagg attcgtcagg aacaggacat ttcacctcag gagtgcgggt cttccgaccc      960

cgaactccac cggaggcaat tgcactgtgt agccgtctgc tggagtatac accaactgcc     1020

cgactaacac cactggaagc ttgtgcacat tcattttttg atgaattacg ggacccaaat     1080

gtcaaactac caaatgggcg agacacacct gcactcttca acttcaccac tcaagaactg     1140

tcaagtaatc cacctctggc taccatcctt attcctcctc atgctcggat tcaagcagct     1200

gcttcaaccc ccacaaatgc cacagcagcg tcagatgcta atactggaga ccgtggacag     1260

accaataatg ctgcttctgc atcagcttcc aactccacct ga                        1302


<210>  304
<211>  387
<212>  DNA
<213>  Homo sapiens;

<400>  304
atgtggtcga cgagaagccc caacagcacg gcgtggcctc tcagcctcga gcctgatccg       60

gggatggcct ctgcctccac cacaatgcat actaccacca ttgcagagcc tgatccaggg      120

atgtctggat ggccggatgg cagaatggag acctccaccc ccaccataat ggacattgtc      180

gtcattgcag gtgtgattgc tgctgtggcc atcgtcctag tctccctcct cttcgtcatg      240

ctgcgctaca tgtaccggca caagggcacg taccacacca atgaggccaa gggcacggag      300

tttgctgaga gtgcagatgc agccctgcag ggagaccctg ccctccaaga tgctggtgat      360

agcagcagaa aggagtactt tatttga                                          387


<210>  305
<211>  1974
<212>  DNA
<213>  Homo sapiens;

<400>  305
atgcccagat acacggtgca cgtacgtggg gaatggctgg cagtgccctg ccaggacgcg       60

cagctcactg tgggctggct gggccgggag gccgtgaggc gctatatcaa gaataagccc      120

gacaatggtg gcttcacctc cgtggatgac gcgcacttcc ttgtgcgccg gtgcaagggc      180

ctgggcctgc tggacaacga ggaccggctc gaggtggccc tagagaacaa cgagttcgtg      240

gaagtggtta tagagggtga tgccatgtct cctgacttca ttccatctca accagaagga      300

gtttatctat acagcaagta ccgggagcct gaaaagtaca tcgagttaga tggagaccgt      360

ctgaccacgg aggatctggt caacttggga aagggacgct acaaaataaa gctcacccca      420

acagctgaga agagggtgca gaaatccagg gaggtcatag atagcatcat aaaagagaaa      480

acagttgttt acggtattac tacaggtttt gggaaatttg ccagaactgt aattcctatc      540

aataagctac aggagcttca ggtcaactta gtacgctcac attcttcagg tgttgggaaa      600

ccactaagtc ctgagaggtg tcggatgctc ttggctttaa ggatcaatgt cttagccaaa      660

ggatacagtg gcatttccct ggagaccctc aaacaagtca tagaaatgtt taatgcctcc      720

tgcctgccct atgtcccaga gaaaggaacc gttggtgcca gtggagacct tgccccactc      780

tctcatcttg ctcttgggct agttggagaa gggaagatgt ggtctccgaa gagtggctgg      840

gctgatgcta aatacgtgct agaagcccat ggattgaaac cagttatttt aaaaccaaaa      900

gagggcctgg cactcatcaa tgggacgcag atgatcacat ccctgggctg tgaagctgta      960

gagcgagcca gtgctattgc acggcaggct gacattgtgg cagccctgac ccttgaggtg     1020

ctgaagggca ccaccaaagc ctttgacact gacattcatg ctcttcgacc tcaccgtggg     1080

caaattgaag ttgcttttcg gtttcggtca ctcttggact cagatcacca cccatcagaa     1140

atagcagaga gtcacaggtt ctgtgatcgc gtccaggatg catacacctt gcgctgctgt     1200

ccacaggtcc atggtgtggt gaatgataca atagcatttg tgaagaacat cattaccaca     1260

gaactgaaca gcgcaacaga taatcctatg gtctttgcca ataggggaga gacagtttct     1320

ggaggaaact tccatggtga atacccagcc aaagccctag actacttggc cattggcatc     1380

catgaacttg ctgcaatcag tgagagaaga atcgagcggc tctgcaatcc ctccctcagt     1440

gagctgcctg ccttcctggt ggctgaaggt ggtctgaact ctgggttcat gatagctcac     1500

tgcacggcag cagcccttgt ttctgagaac aaggctctgt gccatccctc gtctgttgac     1560

tccctctcca ccagcgcagc cacggaggac cacgtctcca tgggaggatg ggcagcaagg     1620

aaagccctca gggtcatcga gcatgtggag caagtgctgg ccatcgagct ccttgcagcc     1680

tgccagggca tagagtttct acgtcccctg aaaacaacca ctccgctgga gaaggtctat     1740

gacctggtgc gctctgttgt aaggccctgg ataaaagatc gcttcatggc cccggacatc     1800

gaggcagccc acaggctgct cctggagcag aaggtttggg aagtagctgc tccatacatt     1860

gaaaaataca gaatggagca tattccagaa tcaagacctc tttctccaac agccttttca     1920

ctgcaatttc tgcacaagaa atccaccaaa atcccggagt ctgaggacct ttaa           1974


<210>  306
<211>  1581
<212>  DNA
<213>  Homo sapiens;

<400>  306
ctgggggggc gctcaagctg cgaggatccg ggctgcccgc gagacgagga gcgggcgccc       60

aggatggggt gcatgaagtc caagttcctc caggtcggag gcaatacatt ctcaaaaact      120

gaaaccagcg ccagcccaca ctgtcctgtg tacgtgccgg atcccacatc caccatcaag      180

ccggggccta atagccacaa cagcaacaca ccaggaatca gggaggcagg ctctgaggac      240

atcatcgtgg ttgccctgta tgattacgag gccattcacc acgaagacct cagcttccag      300

aagggggacc agatggtggt cctagaggaa tccggggagt ggtggaaggc tcgatccctg      360

gccacccgga aggagggcta catcccaagc aactatgtcg cccgcgttga ctctctggag      420

acagaggagt ggtttttcaa gggcatcagc cggaaggacg cagagcgcca actgctggct      480

cccggcaaca tgctgggctc cttcatgatc cgggatagcg agaccactaa aggaagctac      540

tctttgtccg tgcgagacta cgaccctcgg cagggagata ccgtgaaaca ttacaagatc      600

cggaccctgg acaacggggg cttctacata tccccccgaa gcaccttcag cactctgcag      660

gagctggtgg accactacaa gaaggggaac gacgggctct gccagaaact gtcggtgccc      720

tgcatgtctt ccaagcccca gaagccttgg gagaaagatg cctgggagat ccctcgggaa      780

tccctcaagc tggagaagaa acttggagct gggcagtttg gggaagtctg gatggccacc      840

tacaacaagc acaccaaggt ggcagtgaag acgatgaagc cagggagcat gtcggtggag      900

gccttcctgg cagaggccaa cgtgatgaaa actctgcagc atgacaagct ggtcaaactt      960

catgcggtgg tcaccaagga gcccatctac atcatcacgg agttcatggc caaaggaagc     1020

ttgctggact ttctgaaaag tgatgagggc agcaagcagc cattgccaaa actcattgac     1080

ttctcagccc agattgcaga aggcatggcc ttcatcgagc agaggaacta catccaccga     1140

gacctccgag ctgccaacat cttggtctct gcatccctgg tgtgtaagat tgctgacttt     1200

ggcctggccc gggtcattga ggacaacgag tacacggctc gggaaggggc caagttcccc     1260

atcaagtgga cagctcctga agccatcaac tttggctcct tcaccatcaa gtcagacgtc     1320

tggtcctttg gtatcctgct gatggagatc gtcacctacg gccggatccc ttacccaggg     1380

atgtcaaacc ctgaagtgat ccgagctctg gagcgtggat accggatgcc tcgcccagag     1440

aactgcccag aggagctcta caacatcatg atgcgctgct ggaaaaaccg tccggaggag     1500

cggccgacct tcgaatacat ccagagtgtg ctggatgact tctacacggc cacagagagc     1560

cagtaccaac agcagccatg a                                               1581


<210>  307
<211>  3075
<212>  DNA
<213>  Homo sapiens;

<400>  307
atggagcgga ggtcgcggag gaagtcgcgg cgcaacgggc gctcgaccgc gggcaaggcc       60

gccgcgaccc agcccgcgaa gtctccgggc gcacagctct ggctctttcc cagcgccgcg      120

ggcctccacc gcgcgctgct ccggagggtg gaggtgacgc gccaactctg ctgctcgccg      180

gggcgcctcg cggtcttgga acgcggcggg gcgggcgtcc aggttcacca gctgctcgcc      240

gggagcggcg gcgcccggac gccgaaatgc attaaattag gaaaaaacat gaagatacat      300

tccgtggacc aaggagcaga gcacatgctg attctctcat cagatggaaa accatttgag      360

tatgacaact atagcatgaa acatctaagg tttgaaagca ttttacaaga aaaaaaaata      420

attcagatca catgtggaga ttaccattct cttgcactct caaaaggtgg tgagcttttt      480

gcctggggac agaacctgca tgggcagctt ggagttggaa ggaaatttcc ctcaaccacc      540

acaccacaga ttgtggagca cctcgcagga gtacccttgg ctcagatttc tgccggagaa      600

gcccacagca tggccttatc catgtctggc aacatttatt catggggaaa aaatgaatgt      660

ggacaactag gcctgggcca cactgagagt aaagatgatc catcccttat tgaaggacta      720

gacaatcaga aagttgaatt tgtcgcttgt ggtggctctc acagtgccct actcacacag      780

gatgggctgc tgtttacttt cggtgctgga aaacatgggc aacttggtca taattcaaca      840

cagaatgagc taagaccctg tttggtggct gagcttgttg ggtatagagt gactcagata      900

gcatgtggaa ggtggcacac acttgcctat gtttctgatt tgggaaaggt cttttccttt      960

ggttctggaa aagatggaca actgggaaat ggtggaacac gtgaccagct gatgccgctt     1020

ccagtgaaag tatcatcaag tgaagaactc aaacttgaaa gccatacctc agaaaaggag     1080

ttaataatga ttgctggagg gaatcaaagc attttgctct ggataaagaa agagaattca     1140

tatgttaatc tgaagaggac aattcctact ctgaatgaag ggactgtaaa gagatggatt     1200

gctgatgtgg agactaaacg gtggcagagc acaaaaaggg aaatccaaga gatattttca     1260

tctcctgctt gtctaactgg aagtttttta aggaaaagaa gaactacaga aatgatgcct     1320

gtttatttgg acttaaataa agcaagaaac atcttcaagg agttaaccca aaaggactgg     1380

attactaaca tgataaccac ctgcctcaaa gataatctgc tcaaaagact tccatttcat     1440

tctccacccc aagaagcttt agaaattttc ttccttctcc cagaatgtcc tatgatgcat     1500

atttccaaca actgggagag ccttgtggtt ccatttgcaa aggttgtttg taaaatgagt     1560

gaccagtctt cactggttct ggaagagtat tgggcaactc tgcaagaatc cactttcagc     1620

aaactggtcc agatgtttaa aacagccgtc atatgccagt tggattactg ggatgaaagt     1680

gctgaggaga atggtaatgt tcaagctctc ctagaaatgt tgaagaagct gcacagggta     1740

aaccaggtga aatgtcaact acctgaaagt attttccaag tagacgaact cttgcaccgt     1800

ctcaattttt ttgtagaagt atgcagaagg tacttgtgga aaatgactgt ggacgcttca     1860

gaaaatgtac aatgctgcgt catattcagt cactttccat ttatctttaa taatctgtcg     1920

aaaattaaac tactacatac agacacactt ttaaaaatag agagtaaaaa acataaagct     1980

tatcttaggt cggcagcaat tgaggaagaa agagagtctg aattcgcttt gaggcccacg     2040

tttgatctaa cagtcagaag gaatcacttg attgaggatg ttttgaatca gctaagtcaa     2100

tttgagaatg aagacctgag gaaagagtta tgggtttcat ttagtggaga aattgggtat     2160

gacctcggag gagtcaagaa agagttcttc tactgtctgt ttgcagagat gatccagccg     2220

gaatatggga tgttcatgta tcctgaaggg gcttcctgca tgtggtttcc tgtcaagcct     2280

aaatttgaga agaaaagata cttctttttt ggggttctat gtggactttc cctgttcaat     2340

tgcaatgttg ccaaccttcc tttcccactg gcactgttta agaaactttt ggaccaaatg     2400

ccatcattgg aagacttgaa agaactcagt cctgatttgg gaaagaattt gcaaacactt     2460

ctggatgatg aaggtgataa ctttgaggaa gtattttaca tccattttaa tgtgcactgg     2520

gacagaaacg acacaaactt aattcctaat ggaagtagca taactgtcaa ccagactaac     2580

aagagagact atgtttctaa gtatatcaat tacattttca acgactctgt aaaggcggtt     2640

tatgaagaat ttcggagagg attttataaa atgtgcgacg aagacattat caaattattc     2700

caccccgaag aactgaagga tgtgattgtt ggaaatacag attatgattg gaaaacattt     2760

gaaaagaatg cacgttatga accaggatat aacagttcac atcccaccat agtgatgttt     2820

tggaaggctt tccacaaatt gactctggaa gaaaagaaaa aattccttgt atttcttaca     2880

ggaactgaca gactacaaat gaaagattta aataatatga aaataacatt ttgctgtcct     2940

gaaagttgga atgaaagaga ccctataaga gcactgacat gtttcagtgt cctcttcctc     3000

cctaaatatt ctacaatgga aacagttgaa gaagcgcttc aagaagccat caacaacaac     3060

agaggatttg gctga                                                      3075


<210>  308
<211>  3069
<212>  DNA
<213>  Homo sapiens;

<400>  308
atgtacttct gttggggcgc cgactccagg gagctgcagc gccggaggac ggcgggcagc       60

cccggggctg agctactgca ggcggccagc ggggagcgcc actctctgct gctgctgacc      120

aaccacaggg tcctctcgtg cggagacaac agcaggggtc agctgggccg caggggcgcg      180

cagcgcgggg agctgccaga accaattcag gcattggaaa ccctaattgt tgatctcgtg      240

agctgcggga aggagcactc cctggctgtg tgccacaaag gaagggtctt cgcatgggga      300

gctggttctg aagggcagct ggggattgga gaattcaagg aaataagttt cacacctaag      360

aaaataatga ctctgaatga tataaaaata atacaagttt cctgtggaca ctaccactcc      420

ctggcattat caaaagatag ccaagtgttt tcgtggggaa agaacagcca tgggcagctg      480

ggcttgggga aggagttccc ctcccaagcc agcccgcaga gggtgaggtc cctggagggg      540

atcccactgg ctcaggtggc tgccggaggg gctcacagct ttgccctgtc tctctgtggg      600

acttcgtttg gctggggaag taacagtgcc gggcagctgg ccctcagtgg gcgtaatgtc      660

ccagtgcaaa gcaacaagcc tctctcagtc ggtgcactga agaatctagg tgtggtttat      720

atcagctgtg gtgatgcaca cactgcggtg cttacccagg acgggaaagt gttcacattt      780

ggagacaatc gctctggaca gctgggatac agccccactc ctgagaagag aggtccacaa      840

cttgtggaaa gaattgatgg cctagtttcg cagatagatt gtggaagtta tcacaccctg      900

gcatatgtgc acaccactgg tcaggtggta tcttttggtc atggaccaag tgacacaagc      960

aagccaactc atccggaggc cctgacagag aactttgaca ttagctgcct gatttctgct     1020

gaagacttcg tggatgttca agtcaaacac atttttgctg gaacatatgc caactttgtg     1080

acaactcatc aggatactag ttccacacgt gctcccggga aaaccctgcc agaaataagc     1140

cgaattagcc agtccatggc agaaaaatgg atagcagtga aaagaagaag tactgaacat     1200

gaaatggcta aaagtgaaat tagaatgata ttttcatctc ctgcttgtct gactgcaagt     1260

tttttaaaga aaagaggaac tggagaaacg acttccattg atgtggactt agaaatggca     1320

agagatacct tcaagaagtt aacaaaaaag gaatggattt cttccatgat aactacgtgt     1380

ctcgaggatg atctgctcag agctcttcca tgccattctc cacaccaaga agctttatca     1440

gttttcctcc tgctcccaga atgtcctgtg atgcatgatt ctaagaactg gaagaacctg     1500

gtggttccat ttgcaaaggc tgtgtgtgaa atgagtaaac aatctttgca agtcctaaag     1560

aagtgttggg catttttgca agaatcttct ctgaatccgc tgatccagat gcttaaagca     1620

gccatcatct ctcagctgct tcatcagact aaaaccgaac aggatcactg taatgttaaa     1680

gctcttttag gaatgatgaa agaactgcat aaggtaaaca aagctaactg tcgactacca     1740

gaaaatactt tcaacataaa tgaactctcc aacttattaa acttttatat agatagagga     1800

agacagctct ttcgggataa ccacctgata cctgcagaaa cccccagtcc tgttattttc     1860

agtgattttc catttatctt taattcgcta tccaaaatta aattattgca agctgattca     1920

catataaaga tgcagatgtc agaaaagaaa gcatacatgc ttatgcatga aacaattctg     1980

caaaaaaagg atgaatttcc tccatcaccc agatttatac ttagagtcag acgaagtcgc     2040

ctggttaaag atgctctgcg tcaattaagt caagctgaag ctactgactt ctgcaaagta     2100

ttagtggttg aatttattaa tgaaatttgt cctgagtctg gaggggttag ttcagagttc     2160

ttccactgta tgtttgaaga gatgaccaag ccagaatatg gaatgttcat gtatcctgaa     2220

atgggttcct gcatgtggtt tcctgccaag cctaaacctg agaagaaaag atatttcctc     2280

tttggaatgc tgtgtggact ctccttattc aatttaaatg ttgctaacct tcctttccca     2340

ctggctctgt ataaaaaact tctggaccaa aagccatcat tggaagattt aaaagaactc     2400

agtcctcggt tggggaagag tttgcaagaa gttctagatg atgctgctga tgacattgga     2460

gatgcgctct gcatacgctt ttctatacac tgggaccaaa atgatgttga cttaattcca     2520

aatgggatct ccatacctgt ggaccaaacc aacaagagag actatgtttc taagtatatt     2580

gattacattt tcaacgtctc tgtaaaagca gtttatgagg aatttcagag aggattttat     2640

agagtctgtg agaaggagat acttagacat ttctaccctg aagaactaat gacagcaatc     2700

attggaaata ctgattatga ctggaaacag tttgaacaga attcaaagta tgagcaagga     2760

taccaaaaat cacatcctac tatacagttg ttttggaagg ctttccacaa actaaccttg     2820

gatgaaaaga aaaaattcct ctttttcctt acaggacgtg ataggctgca tgcaagaggc     2880

atacagaaaa tggaaatagt atttcgctgt cctgaaactt tcagtgaaag agatcaccca     2940

acatcaataa cttgtcataa tattctctcc ctccctaagt attctacaat ggaaagaatg     3000

gaggaagcac ttcaagtagc catcaacaac aacagaggat ttgtctcacc catgctcaca     3060

cagtcataa                                                             3069


<210>  309
<211>  1908
<212>  DNA
<213>  Homo sapiens;

<400>  309
atgagcgggg cgggcagggc gctggccgcg ctgctgctgg ccgcgtccgt gctgagcgcc       60

gcgctgctgg cccccggcgg ctcttcgggg cgcgatgccc aggccgcgcc gccacgagac      120

ttagacaaaa aaagacatgc agagctgaag atggatcagg ctttgctact catccataat      180

gaacttctct ggaccaactt gaccgtctac tggaaatctg aatgctgtta tcactgcttg      240

tttcaggttc tggtaaacgt tcctcagagt ccaaaagcag ggaagcctag tgctgcagct      300

gcctctgtca gcacccagca cggatctatc ctgcagctga acgacacctt ggaagagaaa      360

gaagtttgta ggttggaata cagatttgga gaatttggaa actattctct cttggtaaag      420

aacatccata atggagttag tgaaattgcc tgtgacctgg ctgtgaacga ggatccagtt      480

gatagtaacc ttcctgtgag cattgcattc cttattggtc ttgctgtcat cattgtgata      540

tcctttctga ggctcttgtt gagtttggat gactttaaca attggatttc taaagccata      600

agttctcgag aaactgatcg cctcatcaat tctgagctgg gatctcccag caggacagac      660

cctctcgatg gtgatgttca gccagcaacg tggcgtctat ctgccctgcc gccccgcctc      720

cgcagcgtgg acaccttcag ggggattgct cttatactca tggtctttgt caattatgga      780

ggaggaaaat attggtactt caaacatgca agttggaatg ggctgacagt ggctgacctc      840

gtgttcccgt ggtttgtatt tattatggga tcttccattt ttctatcgat gacttctata      900

ctgcaacggg ggtgttcaaa attcagattg ctggggaaga ttgcatggag gagtttcctg      960

ttaatctgca taggaattat cattgtgaat cccaattatt gccttggtcc attgtcttgg     1020

gacaaggtgc gcattcctgg tgtgctgcag cgattgggag tgacatactt tgtggttgct     1080

gtgttggagc tcctctttgc taaacctgtg cctgaacatt gtgcctcgga gaggagctgc     1140

ctttctcttc gagacatcac gtccagctgg ccccagtggc tgctcatcct ggtgctggaa     1200

ggcctgtggc tgggcttgac attcctcctg ccagtccctg ggtgccctac tggttatctt     1260

ggtcctgggg gcattggaga ttttggcaag tatccaaatt gcactggagg agctgcaggc     1320

tacatcgacc gcctgctgct gggagacgat cacctttacc agcacccatc ttctgctgta     1380

ctttaccaca ccgaggtggc ctatgacccc gagggcatcc tgggcaccat caactccatc     1440

gtgatggcct ttttaggagt tcaggcagga aaaatactat tgtattacaa ggctcggacc     1500

aaagacatcc tgattcgatt cactgcttgg tgttgtattc ttgggctcat ttctgttgct     1560

ctgacgaagg tttctgaaaa tgaaggcttt attccagtaa acaaaaatct ctggtccctt     1620

tcgtatgtca ctacgctcag ttcttttgcc ttcttcatcc tgctggtcct gtacccagtt     1680

gtggatgtga aggggctgtg gacaggaacc ccattctttt atccaggaat gaattccatt     1740

ctggtatatg tcggccacga ggtgtttgag aactacttcc cctttcagtg gaagctgaag     1800

gacaaccagt cccacaagga gcacctgact cagaacatcg tcgccactgc cctctgggtg     1860

ctcattgcct acatcctcta tagaaagaag attttttgga aaatctga                  1908


<210>  310
<211>  813
<212>  DNA
<213>  Homo sapiens;

<400>  310
atgcagtacc cgcaccccgg gccggcggcg ggcgccgtgg gggtgccgct gtacgcgccc       60

acgccgctgc tgcaacccgc acacccgacg cccttttaca tcgaggacat cctgggccgc      120

gggcccgccg cgcccacgcc cgcccccacg ctgccgtccc ccaactcctc cttcaccagc      180

ctcgtgtccc cctaccggac cccggtgtac gagcccacgc cgatccatcc agccttctcg      240

caccactccg ccgccgcgct ggccgctgcc tacggacccg gcggcttcgg gggccctctg      300

taccccttcc cgcggacggt gaacgactac acgcacgccc tgctccgcca cgaccccctg      360

ggcaaacctc tactctggag ccccttcttg cagaggcctc tgcataaaag gaaaggcggc      420

caggtgagat tctccaacga ccagaccatc gagctggaga agaaattcga gacgcagaaa      480

tatctctctc cgcccgagag gaagcgtctg gccaagatgc tgcagctcag cgagagacag      540

gtcaaaacct ggtttcagaa tcgacgcgct aaatggagga gactaaaaca ggagaaccct      600

caaagcaata aaaaagaaga actggaaagt ttggacagtt cctgtgatca gaggcaagat      660

ttgcccagtg aacagaataa aggtgcttct ttggatagct ctcaatgttc gccctcccct      720

gcctcccagg aagaccttga atcagagatt tcagaggatt ctgatcagga agtggacatt      780

gagggcgata aaagctattt taatgctgga tga                                   813


<210>  311
<211>  3114
<212>  DNA
<213>  Homo sapiens;

<400>  311
atggatcgga tggccagctc catgaagcag gtgcccaacc cactgcccaa ggtgctgagc       60

cggcgcgggg tcggcgctgg gctggaggcg gcggagcgcg agagcttcga gcggactcag      120

actgtcagca tcaataaggc cattaatacg caggaagtgg ctgtaaagga aaaacacgcc      180

agaacgtgca tactgggcac ccaccatgag aaaggggcac agaccttctg gtctgttgtc      240

aaccgcctgc ctctgtctag caacgcagtg ctctgctgga agttctgcca tgtgttccac      300

aaactcctcc gagatggaca cccgaacgtc ctgaaggact ctctgagata cagaaatgaa      360

ttgagtgaca tgagcaggat gtggggccac ctgagcgagg ggtatggcca gctgtgcagc      420

atctacctga aactgctaag aaccaagatg gagtaccaca ccaaaaatcc caggttccca      480

ggcaacctgc agatgagtga ccgccagctg gacgaggctg gagaaagtga cgtgaacaac      540

tttttccagt taacagtgga gatgtttgac tacctggagt gtgaactcaa cctcttccaa      600

acagtattca actccctgga catgtcccgc tctgtgtccg tgacggcagc agggcagtgc      660

cgcctcgccc cgctgatcca ggtcatcttg gactgcagcc acctttatga ctacactgtc      720

aagcttctct tcaaactcca ctcctgcctc ccagctgaca ccctgcaagg ccaccgggac      780

cgcttcatgg agcagtttac aaagttgaaa gatctgttct accgctccag caacctgcag      840

tacttcaagc ggctcattca gatcccccag ctgcctgaga acccacccaa cttcctgcga      900

gcctcagccc tgtcagaaca tatcagccct gtggtggtga tccctgcaga ggcctcatcc      960

cccgacagcg agccagtcct agagaaggat gacctcatgg acatggatgc ctctcagcag     1020

aatttatttg acaacaagtt tgatgacatc tttggcagtt cattcagcag tgatcccttc     1080

aatttcaaca gtcaaaatgg tgtgaacaag gatgagaagg accacttaat tgagcgacta     1140

tacagagaga tcagtggatt gaaggcacag ctagaaaaca tgaagactga gagccagcgg     1200

gttgtgctgc agctgaaggg ccacgtcagc gagctggaag cagatctggc cgagcagcag     1260

cacctgcggc agcaggcggc cgacgactgt gaattcctgc gggcagaact ggacgagctc     1320

aggaggcagc gggaggacac cgagaaggct cagcggagcc tgtctgagat agaaaggaaa     1380

gctcaagcca atgaacagcg atatagcaag ctaaaggaga agtacagcga gctggttcag     1440

aaccacgctg acctgctgcg gaagaatgca gaggtgacca aacaggtgtc catggccaga     1500

caagcccagg tagatttgga acgagagaaa aaagagctgg aggattcgtt ggagcgcatc     1560

agtgaccagg gccagcggaa gactcaagaa cagctggaag ttctagagag cttgaagcag     1620

gaacttgcca caagccaacg ggagcttcag gttctgcaag gcagcctgga aacttctgcc     1680

cagtcagaag caaactgggc agccgagttc gccgagctag agaaggagcg ggacagcctg     1740

gtgagtggcg cagctcatag ggaggaggaa ttatctgctc ttcggaaaga actgcaggac     1800

actcagctca aactggccag cacagaggaa tctatgtgcc agcttgccaa agaccaacga     1860

aaaatgcttc tggtggggtc caggaaggct gcggagcagg tgatacaaga cgccctgaac     1920

cagcttgaag aacctcctct catcagctgc gctgggtctg cagatcacct cctctccacg     1980

gtcacatcca tttccagctg catcgagcaa ctggagaaaa gctggagcca gtatctggcc     2040

tgcccagaag acatcagtgg acttctccat tccataaccc tgctggccca cttgaccagc     2100

gacgccattg ctcatggtgc caccacctgc ctcagagccc cacctgagcc tgccgactca     2160

ctgaccgagg cctgtaagca gtatggcagg gaaaccctcg cctacctggc ctccctggag     2220

gaagagggaa gccttgagaa tgccgacagc acagccatga ggaactgcct gagcaagatc     2280

aaggccatcg gcgaggagct cctgcccagg ggactggaca tcaagcagga ggagctgggg     2340

gacctggtgg acaaggagat ggcggccact tcagctgcta ttgaaactgc cacggccaga     2400

atagaggaga tgctcagcaa atcccgagca ggagacacag gagtcaaatt ggaggtgaat     2460

gaaaggatcc ttggttgctg taccagcctc atgcaagcta ttcaggtgct catcgtggcc     2520

tctaaggacc tccagagaga gattgtggag agcggcaggg gtacagcatc ccctaaagag     2580

ttttatgcca agaactctcg atggacagaa ggacttatct cagcctccaa ggctgtgggc     2640

tggggagcca ctgtcatggt ggatgcagct gatctggtgg tacaaggcag agggaaattt     2700

gaggagctaa tggtgtgttc tcatgaaatt gctgctagca cagcccagct tgtggctgca     2760

tccaaggtga aagctgataa ggacagcccc aacctagccc agctgcagca ggcctctcgg     2820

ggagtgaacc aggccactgc cggcgttgtg gcctcaacca tttccggcaa atcacagatc     2880

gaagagacag acaacatgga cttctcaagc atgacgctga cacagatcaa acgccaagag     2940

atggattctc aggttagggt gctagagcta gaaaatgaat tgcagaagga gcgtcaaaaa     3000

ctgggagagc ttcggaaaaa gcactacgag cttgctggtg ttgctgaggg ctgggaagaa     3060

ggaacagagg catctccacc tacactgcaa gaagtggtaa ccgaaaaaga atag           3114


<210>  312
<211>  582
<212>  DNA
<213>  Homo sapiens;

<400>  312
atgggcaaac agaacagcaa gctgcggccc gaggtgctgc aggacctgcg ggagaacacg       60

gagttcaccg accacgagct gcaggagtgg tacaagggct tcctcaagga ctgccccacc      120

ggccacctga ccgtggacga gttcaagaag atctacgcca acttcttccc ctacggcgac      180

gcttccaagt tcgccgagca cgtcttccgc accttcgaca ccaacggcga cggcaccatc      240

gacttccggg agttcatcat tgcgctgagc gtgacctcgc ggggcaagct ggagcagaag      300

ctcaagtggg ccttcagcat gtacgacctg gacggcaacg gctacatcag ccgcagcgag      360

atgctggaga tcgtgcaggc catctacaag atggtgtcgt ctgtgatgaa gatgccggag      420

gatgagtcca ccccggagaa gcgcacagac aagatcttca ggcagatgga caccaacaat      480

gacggcaaac tgtccttgga agaattcatc agaggtgcca agagcgaccc ctccatcgtc      540

cgcctgctgc agtgcgaccc cagcagtgcc agtcagttct ga                         582


<210>  313
<211>  2103
<212>  DNA
<213>  Homo sapiens;

<400>  313
atgaagtgcg tcttggtggc cactgagggc gcagaggtcc tcttctactg gacagatcag       60

gagtttgaag agagtctccg gctgaagttc gggcagtcag agaatgagga agaagagctc      120

cctgccctgg aggaccagct cagcaccctc ctagccccgg tcatcatctc ctccatgacg      180

atgctggaga agctctcgga cacctacacc tgcttctcca cggaaaatgg caacttcctg      240

tatgtccttc acctgtttgg agaatgcctg ttcattgcca tcaatggtga ccacaccgag      300

agcgaggggg acctgcggcg gaagctgtat gtgctcaagt acctgtttga agtgcacttt      360

gggctggtga ctgtggacgg tcatcttatc cgaaaggagc tgcggccccc agacctggcg      420

cagcgtgtcc agctgtggga gcacttccag agcctgctgt ggacctacag ccgcctgcgg      480

gagcaggagc agtgcttcgc cgtggaggcc ctggagcgac tgattcaccc ccagctctgt      540

gagctgtgca tagaggcgct ggagcggcac gtcatccagg ctgtcaacac cagccccgag      600

cggggaggcg aggaggccct gcatgccttc ctgctcgtgc actccaagct gctggcattc      660

tactctagcc acagtgccag ctccctgcgc ccggccgacc tgcttgccct catcctcctg      720

gttcaggacc tctaccccag cgagagcaca gcagaggacg acattcagcc ttccccgcgg      780

agggcccgga gcagccagaa catccccgtg cagcaggcct ggagccctca ctccacgggc      840

ccaactgggg ggagctctgc agagacggag acagacagct tctccctccc tgaggagtac      900

ttcacaccag ctccttcccc tggcgatcag agctcaggta gcaccatctg gctggagggg      960

ggcacccccc ccatggatgc ccttcagata gcagaggaca ccctccaaac actggttccc     1020

cactgccctg tgccttccgg ccccagaagg atcttcctgg atgccaacgt gaaggaaagc     1080

tactgccccc tagtgcccca caccatgtac tgcctgcccc tgtggcaggg catcaacctg     1140

gtgctcctga ccaggagccc cagcgcgccc ctggccctgg ttctgtccca gctgatggat     1200

ggcttctcca tgctggagaa gaagctgaag gaagggccgg agcccggggc ctccctgcgc     1260

tcccagcccc tcgtgggaga cctgcgccag aggatggaca agtttgtcaa gaatcgaggg     1320

gcacaggaga ttcagagcac ctggctggag tttaaggcca aggctttctc caaaagtgag     1380

cccggatcct cctgggagct gctccaggca tgtgggaagc tgaagcggca gctctgcgcc     1440

atctaccggc tgaactttct gaccacagcc cccagcaggg gaggcccaca cctgccccag     1500

cacctgcagg accaagtgca gaggctcatg cgggagaagc tgacggactg gaaggacttc     1560

ttgctggtga agagcaggag gaacatcacc atggtgtcct acctagaaga cttcccaggc     1620

ttggtgcact tcatctatgt ggaccgcacc actgggcaga tggtggcgcc ttccctcaac     1680

tgcagtcaaa agacctcgtc ggagttgggc aaggggccgc tggctgcctt tgtcaaaact     1740

aaggtctggt ctctgatcca gctggcgcgc agatacctgc agaagggcta caccacgctg     1800

ctgttccagg agggggattt ctactgctcc tacttcctgt ggttcgagaa tgacatgggg     1860

tacaaactcc agatgatcga ggtgcccgtc ctctccgacg actcagtgcc tatcggcatg     1920

ctgggaggag actactacag gaagctcctg cgctactaca gcaagaaccg cccaaccgag     1980

gctgtcaggt gctacgagct gctggccctg cacctgtctg tcatccccac tgacctgctg     2040

gtgcagcagg ccggccagct ggcccggcgc ctctgggagg cctcccgtat ccccctgctc     2100

tag                                                                   2103


<210>  314
<211>  1644
<212>  DNA
<213>  Homo sapiens;

<400>  314
atggccacca tggtaccatc cgtgttgtgg cccagggcct gctggactct gctggtctgc       60

tgtctgctga ccccaggtgt ccaggggcag gagttccttt tgcgggtgga gccccagaac      120

cctgtgctct ctgctggagg gtccctgttt gtgaactgca gtactgattg tcccagctct      180

gagaaaatcg ccttggagac gtccctatca aaggagctgg tggccagtgg catgggctgg      240

gcagccttca atctcagcaa cgtgactggc aacagtcgga tcctctgctc agtgtactgc      300

aatggctctc agataacagg ctcctctaac atcaccgtgt acaggctccc ggagcgtgtg      360

gagctggcac ccctgcctcc ttggcagccg gtgggccaga acttcaccct gcgctgccaa      420

gtggaggatg ggtcgccccg gaccagcctc acggtggtgc tgcttcgctg ggaggaggag      480

ctgagccggc agcccgcagt ggaggagcca gcggaggtca ctgccactgt gctggccagc      540

agagacgacc acggagcccc tttctcatgc cgcacagaac tggacatgca gccccagggg      600

ctgggactgt tcgtgaacac ctcagccccc cgccagctcc gaacctttgt cctgcccgtg      660

acccccccgc gcctcgtggc cccccggttc ttggaggtgg aaacgtcgtg gccggtggac      720

tgcaccctag acgggctttt tccagcctca gaggcccagg tctacctggc gctgggggac      780

cagatgctga atgcgacagt catgaaccac ggggacacgc taacggccac agccacagcc      840

acggcgcgcg cggatcagga gggtgcccgg gagatcgtct gcaacgtgac cctagggggc      900

gagagacggg aggcccggga gaacttgacg gtctttagct tcctaggacc cattgtgaac      960

ctcagcgagc ccaccgccca tgaggggtcc acagtgaccg tgagttgcat ggctggggct     1020

cgagtccagg tcacgctgga cggagttccg gccgcggccc cggggcagcc agctcaactt     1080

cagctaaatg ctaccgagag tgacgacgga cgcagcttct tctgcagtgc cactctcgag     1140

gtggacggcg agttcttgca caggaacagt agcgtccagc tgcgagtcct gtatggtccc     1200

aaaattgacc gagccacatg cccccagcac ttgaaatgga aagataaaac gagacacgtc     1260

ctgcagtgcc aagccagggg caacccgtac cccgagctgc ggtgtttgaa ggaaggctcc     1320

agccgggagg tgccggtggg gatcccgttc ttcgtcaacg taacacataa tggtacttat     1380

cagtgccaag cgtccagctc acgaggcaaa tacaccctgg tcgtggtgat ggacattgag     1440

gctgggagct cccactttgt ccccgtcttc gtggcggtgt tactgaccct gggcgtggtg     1500

actatcgtac tggccttaat gtacgtcttc agggagcacc aacggagcgg cagttaccat     1560

gttagggagg agagcaccta tctgcccctc acgtctatgc agccgacaga agcaatgggg     1620

gaagaaccgt ccagagctga gtga                                            1644


<210>  315
<211>  1335
<212>  DNA
<213>  Homo sapiens;

<400>  315
atggcagtga caactcgttt gacatggttg cacgaaaaga tcctgcaaaa tcattttgga       60

gggaagcggc ttagccttct ctataagggt agtgtccatg gattccgtaa tggagttttg      120

cttgacagat gttgtaatca agggcctact ctaacagtga tttatagtga agatcatatt      180

attggagcat atgcagaaga gagttaccag gaaggaaagt atgcttccat catccttttt      240

gcacttcaag atactaaaat ttcagaatgg aaactaggac tatgtacacc agaaacactg      300

ttttgttgtg atgttacaaa atataactcc ccaactaatt tccagataga tggaagaaat      360

agaaaagtga ttatggactt aaagacaatg gaaaatcttg gacttgctca aaattgtact      420

atctctattc aggattatga agtttttcga tgcgaagatt cactggatga aagaaagata      480

aaaggggtca ttgagctcag gaagagctta ctgtctgcct tgagaactta tgaaccatat      540

ggatccctgg ttcaacaaat acgaattctg ctgctgggtc caattggagc tgggaagtcc      600

agctttttca actcagtgag gtctgttttc caagggcatg taacgcatca ggctttggtg      660

ggcactaata caactgggat atctgagaag tataggacat actctattag agacgggaaa      720

gatggcaaat acctgccgtt tattctgtgt gactcactgg ggctgagtga gaaagaaggc      780

ggcctgtgca gggatgacat attctatatc ttgaacggta acattcgtga tagataccag      840

tttaatccca tggaatcaat caaattaaat catcatgact acattgattc cccatcgctg      900

aaggacagaa ttcattgtgt ggcatttgta tttgatgcca gctctattca atacttctcc      960

tctcagatga tagtaaagat caaaagaatt cgaagggagt tggtaaacgc tggtgtggta     1020

catgtggctt tgctcactca tgtggatagc atggatttga ttacaaaagg tgaccttata     1080

gaaatagaga gatgtgagcc tgtgaggtcc aagctagagg aagtccaaag aaaacttgga     1140

tttgctcttt ctgacatctc ggtggttagc aattattcct ctgagtggga gctggaccct     1200

gtaaaggatg ttctaattct ttctgctctg agacgaatgc tatgggctgc agatgacttc     1260

ttagaggatt tgccttttga gcaaataggg aatctaaggg aggaaattat caactgtgca     1320

caaggaaaaa aatag                                                      1335


<210>  316
<211>  393
<212>  DNA
<213>  Homo sapiens;

<400>  316
atgcggcaga aggcggtatc gcttttcttg tgctacctgc tgctcttcac ttgcagtggg       60

gtggaggcag gtaagaaaaa gtgctcggag agctcggaca gcggctccgg gttctggaag      120

gccctgacct tcatggccgt cggaggagga ctcgcagtcg ccgggctgcc cgcgctgggc      180

ttcaccggcg ccggcatcgc ggccaactcg gtggctgcct cgctgatgag ctggtctgcg      240

atcctgaatg ggggcggcgt gcccgccggg gggctagtgg ccacgctgca gagcctcggg      300

gctggtggca gcagcgtcgt cataggtaat attggtgccc tgatgggcta cgccacccac      360

aagtatctcg atagtgagga ggatgaggag tag                                   393


<210>  317
<211>  3078
<212>  DNA
<213>  Homo sapiens;

<400>  317
atgtcgaatg ggtattccac agacgagaat ttccgctatc tcatctcgtg cttcagggcc       60

agggtgaaaa tgtacatcca ggtggagcct gtgctggact acctgacctt tctgcctgca      120

gaggtgaagg agcagattca gaggacagtc gccacctccg ggaacatgca ggcagttgaa      180

ctgctgctga gcaccttgga gaagggagtc tggcaccttg gttggactcg ggaattcgtg      240

gaggccctcc ggagaaccgg cagccctctg gccgcccgct acatgaaccc tgagctcacg      300

gacttgccct ctccatcgtt tgagaacgct catgatgaat atctccaact gctgaacctc      360

cttcagccca ctctggtgga caagcttcta gttagagacg tcttggataa gtgcatggag      420

gaggaactgt tgacaattga agacagaaac cggattgctg ctgcagaaaa caatggaaat      480

gaatcaggtg taagagagct actaaaaagg attgtgcaga aagaaaactg gttctctgca      540

tttctgaatg ttcttcgtca aacaggaaac aatgaacttg tccaagagtt aacaggctct      600

gattgctcag aaagcaatgc agagattgag aatttatcac aagttgatgg tcctcaagtg      660

gaagagcaac ttctttcaac cacagttcag ccaaatctgg agaaggaggt ctggggcatg      720

gagaataact catcagaatc atcttttgca gattcttctg tagtttcaga atcagacaca      780

agtttggcag aaggaagtgt cagctgctta gatgaaagtc ttggacataa cagcaacatg      840

ggcagtgatt caggcaccat gggaagtgat tcagatgaag agaatgtggc agcaagagca      900

tccccggagc cagaactcca gctcaggcct taccaaatgg aagttgccca gccagccttg      960

gaagggaaga atatcatcat ctgcctccct acagggagtg gaaaaaccag agtggctgtt     1020

tacattgcca aggatcactt agacaagaag aaaaaagcat ctgagcctgg aaaagttata     1080

gttcttgtca ataaggtact gctagttgaa cagctcttcc gcaaggagtt ccaaccattt     1140

ttgaagaaat ggtatcgtgt tattggatta agtggtgata cccaactgaa aatatcattt     1200

ccagaagttg tcaagtcctg tgatattatt atcagtacag ctcaaatcct tgaaaactcc     1260

ctcttaaact tggaaaatgg agaagatgct ggtgttcaat tgtcagactt ttccctcatt     1320

atcattgatg aatgtcatca caccaacaaa gaagcagtgt ataataacat catgaggcat     1380

tatttgatgc agaagttgaa aaacaataga ctcaagaaag aaaacaaacc agtgattccc     1440

cttcctcaga tactgggact aacagcttca cctggtgttg gaggggccac gaagcaagcc     1500

aaagctgaag aacacatttt aaaactatgt gccaatcttg atgcatttac tattaaaact     1560

gttaaagaaa accttgatca actgaaaaac caaatacagg agccatgcaa gaagtttgcc     1620

attgcagatg caaccagaga agatccattt aaagagaaac ttctagaaat aatgacaagg     1680

attcaaactt attgtcaaat gagtccaatg tcagattttg gaactcaacc ctatgaacaa     1740

tgggccattc aaatggaaaa aaaagctgca aaagaaggaa atcgcaaaga acgtgtttgt     1800

gcagaacatt tgaggaagta caatgaggcc ctacaaatta atgacacaat tcgaatgata     1860

gatgcgtata ctcatcttga aactttctat aatgaagaga aagataagaa gtttgcagtc     1920

atagaagatg atagtgatga gggtggtgat gatgagtatt gtgatggtga tgaagatgag     1980

gatgatttaa agaaaccttt gaaactggat gaaacagata gatttctcat gactttattt     2040

tttgaaaaca ataaaatgtt gaaaaggctg gctgaaaacc cagaatatga aaatgaaaag     2100

ctgaccaaat taagaaatac cataatggag caatatacta ggactgagga atcagcacga     2160

ggaataatct ttacaaaaac acgacagagt gcatatgcgc tttcccagtg gattactgaa     2220

aatgaaaaat ttgctgaagt aggagtcaaa gcccaccatc tgattggagc tggacacagc     2280

agtgagttca aacccatgac acagaatgaa caaaaagaag tcattagtaa atttcgcact     2340

ggaaaaataa atctgcttat cgctaccaca gtggcagaag aaggtctgga tattaaagaa     2400

tgtaacattg ttatccgtta tggtctcgtc accaatgaaa tagccatggt ccaggcccgt     2460

ggtcgagcca gagctgatga gagcacctac gtcctggttg ctcacagtgg ttcaggagtt     2520

atcgaacatg agacagttaa tgatttccga gagaagatga tgtataaagc tatacattgt     2580

gttcaaaata tgaaaccaga ggagtatgct cataagattt tggaattaca gatgcaaagt     2640

ataatggaaa agaaaatgaa aaccaagaga aatattgcca agcattacaa gaataaccca     2700

tcactaataa ctttcctttg caaaaactgc agtgtgctag cctgttctgg ggaagatatc     2760

catgtaattg agaaaatgca tcacgtcaat atgaccccag aattcaagga actttacatt     2820

gtaagagaaa acaaagcact gcaaaagaag tgtgccgact atcaaataaa tggtgaaatc     2880

atctgcaaat gtggccaggc ttggggaaca atgatggtgc acaaaggctt agatttgcct     2940

tgtctcaaaa taaggaattt tgtagtggtt ttcaaaaata attcaacaaa gaaacaatac     3000

aaaaagtggg tagaattacc tatcacattt cccaatcttg actattcaga atgctgttta     3060

tttagtgatg aggattag                                                   3078


<210>  318
<211>  726
<212>  DNA
<213>  Homo sapiens;

<400>  318
atggggactg cgagcagaag caacatcgct cgccatctgc aaaccaatct cattctattt       60

tgtgtcggtg ctgtgggcgc ctgtactctc tctgtcacac aaccgtggta cctagaagtg      120

gactacactc atgaggccgt caccataaag tgtaccttct ccgcaaccgg atgcccttct      180

gagcaaccaa catgcctgtg gtttcgctac ggtgctcacc agcctgagaa cctgtgcttg      240

gacgggtgca aaagtgaggc agacaagttc acagtgaggg aggccctcaa agaaaaccaa      300

gtttccctca ctgtaaacag agtgacttca aatgacagtg caatttacat ctgtggaata      360

gcattcccca gtgtgccgga agcgagagct aaacagacag gaggagggac cacactggtg      420

gtaagagaaa ttaagctgct cagcaaggaa ctgcggagct tcctgacagc tcttgtatca      480

ctgctctctg tctatgtgac cggtgtgtgc gtggccttca tactcctctc caaatcaaaa      540

tccaaccctc taagaaacaa agaaataaaa gaagactcac aaaagaagaa gagtgctcgg      600

cgtatttttc aggaaattgc tcaagaacta taccataaga gacatgtgga aacaaatcag      660

caatctgaga aagataacaa cacttatgaa aacagaagag tactttccaa ctatgaaagg      720

ccatag                                                                 726


<210>  319
<211>  2271
<212>  DNA
<213>  Homo sapiens;

<400>  319
atgagctggt caccttccct gacaacgcag acatgtgggg cctgggaaat gaaagagcgc       60

cttgggacag ggggatttgg aaatgtcatc cgatggcaca atcaggaaac aggtgagcag      120

attgccatca agcagtgccg gcaggagctc agcccccgga accgagagcg gtggtgcctg      180

gagatccaga tcatgagaag gctgacccac cccaatgtgg tggctgcccg agatgtccct      240

gaggggatgc agaacttggc gcccaatgac ctgcccctgc tggccatgga gtactgccaa      300

ggaggagatc tccggaagta cctgaaccag tttgagaact gctgtggtct gcgggaaggt      360

gccatcctca ccttgctgag tgacattgcc tctgcgctta gataccttca tgaaaacaga      420

atcatccatc gggatctaaa gccagaaaac atcgtcctgc agcaaggaga acagaggtta      480

atacacaaaa ttattgacct aggatatgcc aaggagctgg atcagggcag tctttgcaca      540

tcattcgtgg ggaccctgca gtacctggcc ccagagctac tggagcagca gaagtacaca      600

gtgaccgtcg actactggag cttcggcacc ctggcctttg agtgcatcac gggcttccgg      660

cccttcctcc ccaactggca gcccgtgcag tggcattcaa aagtgcggca gaagagtgag      720

gtggacattg ttgttagcga agacttgaat ggaacggtga agttttcaag ctctttaccc      780

taccccaata atcttaacag tgtcctggct gagcgactgg agaagtggct gcaactgatg      840

ctgatgtggc acccccgaca gaggggcacg gatcccacgt atgggcccaa tggctgcttc      900

aaggccctgg atgacatctt aaacttaaag ctggttcata tcttgaacat ggtcacgggc      960

accatccaca cctaccctgt gacagaggat gagagtctgc agagcttgaa ggccagaatc     1020

caacaggaca cgggcatccc agaggaggac caggagctgc tgcaggaagc gggcctggcg     1080

ttgatccccg ataagcctgc cactcagtgt atttcagacg gcaagttaaa tgagggccac     1140

acattggaca tggatcttgt ttttctcttt gacaacagta aaatcaccta tgagactcag     1200

atctccccac ggccccaacc tgaaagtgtc agctgtatcc ttcaagagcc caagaggaat     1260

ctcgccttct tccagctgag gaaggtgtgg ggccaggtct ggcacagcat ccagaccctg     1320

aaggaagatt gcaaccggct gcagcaggga cagcgagccg ccatgatgaa tctcctccga     1380

aacaacagct gcctctccaa aatgaagaat tccatggctt ccatgtctca gcagctcaag     1440

gccaagttgg atttcttcaa aaccagcatc cagattgacc tggagaagta cagcgagcaa     1500

accgagtttg ggatcacatc agataaactg ctgctggcct ggagggaaat ggagcaggct     1560

gtggagctct gtgggcggga gaacgaagtg aaactcctgg tagaacggat gatggctctg     1620

cagaccgaca ttgtggactt acagaggagc cccatgggcc ggaagcaggg gggaacgctg     1680

gacgacctag aggagcaagc aagggagctg tacaggagac taagggaaaa acctcgagac     1740

cagcgaactg agggtgacag tcaggaaatg gtacggctgc tgcttcaggc aattcagagc     1800

ttcgagaaga aagtgcgagt gatctatacg cagctcagta aaactgtggt ttgcaagcag     1860

aaggcgctgg aactgttgcc caaggtggaa gaggtggtga gcttaatgaa tgaggatgag     1920

aagactgttg tccggctgca ggagaagcgg cagaaggagc tctggaatct cctgaagatt     1980

gcttgtagca aggtccgtgg tcctgtcagt ggaagcccgg atagcatgaa tgcctctcga     2040

cttagccagc ctgggcagct gatgtctcag ccctccacgg cctccaacag cttacctgag     2100

ccagccaaga agagtgaaga actggtggct gaagcacata acctctgcac cctgctagaa     2160

aatgccatac aggacactgt gagggaacaa gaccagagtt tcacggccct agactggagc     2220

tggttacaga cggaagaaga agagcacagc tgcctggagc aggcctcatg a              2271


<210>  320
<211>  978
<212>  DNA
<213>  Homo sapiens;

<400>  320
atggcgtgga gccttgggag ctggctgggt ggctgcctgc tggtgtcagc attgggaatg       60

gtaccacctc ccgaaaatgt cagaatgaat tctgttaatt tcaagaacat tctacagtgg      120

gagtcacctg cttttgccaa agggaacctg actttcacag ctcagtacct aagttatagg      180

atattccaag ataaatgcat gaatactacc ttgacggaat gtgatttctc aagtctttcc      240

aagtatggtg accacacctt gagagtcagg gctgaatttg cagatgagca ttcagactgg      300

gtaaacatca ccttctgtcc tgtggatgac accattattg gaccccctgg aatgcaagta      360

gaagtacttg ctgattcttt acatatgcgt ttcttagccc ctaaaattga gaatgaatac      420

gaaacttgga ctatgaagaa tgtgtataac tcatggactt ataatgtgca atactggaaa      480

aacggtactg atgaaaagtt tcaaattact ccccagtatg actttgaggt cctcagaaac      540

ctggagccat ggacaactta ttgtgttcaa gttcgagggt ttcttcctga tcggaacaaa      600

gctggggaat ggagtgagcc tgtctgtgag caaacaaccc atgacgaaac ggtcccctcc      660

tggatggtgg ccgtcatcct catggcctcg gtcttcatgg tctgcctggc actcctcggc      720

tgcttcgcct tgctgtggtg cgtttacaag aagacaaagt acgccttctc ccctaggaat      780

tctcttccac agcacctgaa agagtttttg ggccatcctc atcataacac acttctgttt      840

ttctcctttc cattgtcgga tgagaatgat gtttttgaca agctaagtgt cattgcagaa      900

gactctgaga gcggcaagca gaatcctggt gacagctgca gcctcgggac cccgcctggg      960

caggggcccc aaagctag                                                    978


<210>  321
<211>  1284
<212>  DNA
<213>  Homo sapiens;

<400>  321
atggagtggc cggcgcggct ctgcgggctg tgggcgctgc tgctctgcgc cggcggcggg       60

ggcgggggcg ggggcgccgc gcctacggaa actcagccac ctgtgacaaa tttgagtgtc      120

tctgttgaaa acctctgcac agtaatatgg acatggaatc cacccgaggg agccagctca      180

aattgtagtc tatggtattt tagtcatttt ggcgacaaac aagataagaa aatagctccg      240

gaaactcgtc gttcaataga agtacccctg aatgagagga tttgtctgca agtggggtcc      300

cagtgtagca ccaatgagag tgagaagcct agcattttgg ttgaaaaatg catctcaccc      360

ccagaaggtg atcctgagtc tgctgtgact gagcttcaat gcatttggca caacctgagc      420

tacatgaagt gttcttggct ccctggaagg aataccagtc ccgacactaa ctatactctc      480

tactattggc acagaagcct ggaaaaaatt catcaatgtg aaaacatctt tagagaaggc      540

caatactttg gttgttcctt tgatctgacc aaagtgaagg attccagttt tgaacaacac      600

agtgtccaaa taatggtcaa ggataatgca ggaaaaatta aaccatcctt caatatagtg      660

cctttaactt cccgtgtgaa acctgatcct ccacatatta aaaacctctc cttccacaat      720

gatgacctat atgtgcaatg ggagaatcca cagaatttta ttagcagatg cctattttat      780

gaagtagaag tcaataacag ccaaactgag acacataatg ttttctacgt ccaagaggct      840

aaatgtgaga atccagaatt tgagagaaat gtggagaata catcttgttt catggtccct      900

ggtgttcttc ctgatacttt gaacacagtc agaataagag tcaaaacaaa taagttatgc      960

tatgaggatg acaaactctg gagtaattgg agccaagaaa tgagtatagg taagaagcgc     1020

aattccacac tctacataac catgttactc attgttccag tcatcgtcgc aggtgcaatc     1080

atagtactcc tgctttacct aaaaaggctc aagattatta tattccctcc aattcctgat     1140

cctggcaaga tttttaaaga aatgtttgga gaccagaatg atgatactct gcactggaag     1200

aagtacgaca tctatgagaa gcaaaccaag gaggaaaccg actctgtagt gctgatagaa     1260

aacctgaaga aagcctctca gtga                                            1284


<210>  322
<211>  1896
<212>  DNA
<213>  Homo sapiens;

<400>  322
atggactata gctttgatac cacagccgaa gacccttggg ttaggatttc tgactgcatc       60

aaaaacttat ttagccccat catgagtgag aaccatggcc acatgcctct acagcccaat      120

gccagcctga atgaagaaga agggacacag ggccacccag atgggacccc accaaagctg      180

gacaccgcca atggcactcc caaagtttac aagtcagcag acagcagcac tgtgaagaaa      240

ggtcctcctg tggctcccaa gccagcctgg tttcgccaaa gcttgaaagg tttgaggaat      300

cgtgcttcag acccaagagg gctccctgat cctgccttgt ccacccagcc agcacctgct      360

tccagggagc acctaggatc acacatccgg gcctcctcct cctcctcctc catcaggcag      420

agaatcagct cctttgaaac ctttggctcc tctcaactgc ctgacaaagg agcccagaga      480

ctgagcctcc agccctcctc tggggaggca gcaaaacctc ttgggaagca tgaggaagga      540

cggttttctg gactcttggg gcgaggggct gcacccactc ttgtgcccca gcagcctgag      600

caagtactgt cctcggggtc ccctgcagcc tccgaggcca gagacccagg tgtgtctgag      660

tcccctcccc cagggcggca gcccaatcag aaaactctcc cccctggccc ggacccgctc      720

ctaaggctgc tgtcaacaca ggctgaggaa tctcaaggcc cagtgctcaa gatgcctagc      780

cagcgagcac ggagcttccc cctgaccagg tcccagtcct gtgagacgaa gctacttgac      840

gaaaagacca gcaaactcta ttctatcagc agccaagtgt catcggctgt catgaaatcc      900

ttgctgtgcc ttccatcttc tatctcctgt gcccagactc cctgcatccc caaggaaggg      960

gcatctccaa catcatcatc caacgaagac tcagctgcaa atggttctgc tgaaacatct     1020

gccttggaca cagggttctc gctcaacctt tcagagctga gagaatatac agagggtctc     1080

acggaagcca aggaagacga tgatggggac cacagttccc ttcagtctgg tcagtccgtt     1140

atctccctgc tgagctcaga agaattaaaa aaactcatcg aggaggtgaa ggttctggat     1200

gaagcaacat taaagcaatt agacggcatc catgtcacca tcttacacaa ggaggaaggt     1260

gctggtcttg ggttcagctt ggcaggagga gcagatctag aaaacaaggt gattacggtt     1320

cacagagtgt ttccaaatgg gctggcctcc caggaaggga ctattcagaa gggcaatgag     1380

gttctttcca tcaacggcaa gtctctcaag gggaccacgc accatgatgc cttggccatc     1440

ctccgccaag ctcgagagcc caggcaagct gtgattgtca caaggaagct gactccagag     1500

gccatgcccg acctcaactc ctccactgac tctgcagcct cagcctctgc agccagtgat     1560

gtttctgtag aatctacagc agaggccaca gtctgcacgg tgacactgga gaagatgtcg     1620

gcagggctgg gcttcagcct ggaaggaggg aagggctccc tacacggaga caagcctctc     1680

accattaaca ggattttcaa aggagcagcc tcagaacaaa gtgagacagt ccagcctgga     1740

gatgaaatct tacagctggg tggcactgcc atgcagggcc tcacacggtt tgaagcctgg     1800

aacatcatca aggcactgcc tgatggacct gtcacgattg tcatcaggag aaaaagcctc     1860

cagtccaagg aaaccacagc tgctggagac tcctag                               1896


<210>  323
<211>  1713
<212>  DNA
<213>  Homo sapiens;

<400>  323
atgacacttc tgtggtgtgt agtgagtctc tacttttatg gaatcctgca aagtgatgcc       60

tcagaacgct gcgatgactg gggactagac accatgaggc aaatccaagt gtttgaagat      120

gagccagctc gcatcaagtg cccactcttt gaacacttct tgaaattcaa ctacagcaca      180

gcccattcag ctggccttac tctgatctgg tattggacta ggcaggaccg ggaccttgag      240

gagccaatta acttccgcct ccccgagaac cgcattagta aggagaaaga tgtgctgtgg      300

ttccggccca ctctcctcaa tgacactggc aactatacct gcatgttaag gaacactaca      360

tattgcagca aagttgcatt tcccttggaa gttgttcaaa aagacagctg tttcaattcc      420

cccatgaaac tcccagtgca taaactgtat atagaatatg gcattcagag gatcacttgt      480

ccaaatgtag atggatattt tccttccagt gtcaaaccga ctatcacttg gtatatgggc      540

tgttataaaa tacagaattt taataatgta atacccgaag gtatgaactt gagtttcctc      600

attgccttaa tttcaaataa tggaaattac acatgtgttg ttacatatcc agaaaatgga      660

cgtacgtttc atctcaccag gactctgact gtaaaggtag taggctctcc aaaaaatgca      720

gtgccccctg tgatccattc acctaatgat catgtggtct atgagaaaga accaggagag      780

gagctactca ttccctgtac ggtctatttt agttttctga tggattctcg caatgaggtt      840

tggtggacca ttgatggaaa aaaacctgat gacatcacta ttgatgtcac cattaacgaa      900

agtataagtc atagtagaac agaagatgaa acaagaactc agattttgag catcaagaaa      960

gttacctctg aggatctcaa gcgcagctat gtctgtcatg ctagaagtgc caaaggcgaa     1020

gttgccaaag cagccaaggt gaagcagaaa gtgccagctc caagatacac agtggaactg     1080

gcttgtggtt ttggagccac agtcctgcta gtggtgattc tcattgttgt ttaccatgtt     1140

tactggctag agatggtcct attttaccgg gctcattttg gaacagatga aaccatttta     1200

gatggaaaag agtatgatat ttatgtatcc tatgcaagga atgcggaaga agaagaattt     1260

gtattactga ccctccgtgg agttttggag aatgaatttg gatacaagct gtgcatcttt     1320

gaccgagaca gtctgcctgg gggaattgtc acagatgaga ctttgagctt cattcagaaa     1380

agcagacgcc tcctggttgt tctaagcccc aactacgtgc tccagggaac ccaagccctc     1440

ctggagctca aggctggcct agaaaatatg gcctctcggg gcaacatcaa cgtcatttta     1500

gtacagtaca aagctgtgaa ggaaacgaag gtgaaagagc tgaagagggc taagacggtg     1560

ctcacggtca ttaaatggaa aggggaaaaa tccaagtatc cacagggcag gttctggaag     1620

cagctgcagg tggccatgcc agtgaagaaa agtcccaggc ggtctagcag tgatgagcag     1680

ggcctctcgt attcatcttt gaaaaatgta tga                                  1713


<210>  324
<211>  1911
<212>  DNA
<213>  Homo sapiens;

<400>  324
atgcggggag gcaggggcgc ccctttctgg ctgtggccgc tgcccaagct ggcgctgctg       60

cctctgttgt gggtgctttt ccagcggacg cgtccccagg gcagcgccgg gccactgcag      120

tgctacggag ttggaccctt gggcgacttg aactgctcgt gggagcctct tggggacctg      180

ggagccccct ccgagttaca cctccagagc caaaagtacc gttccaacaa aacccagact      240

gtggcagtgg cagccggacg gagctgggtg gccattcctc gggaacagct caccatgtct      300

gacaaactcc ttgtctgggg cactaaggca ggccagcctc tctggccccc cgtcttcgtg      360

aacctagaaa cccaaatgaa gccaaacgcc ccccggctgg gccctgacgt ggacttttcc      420

gaggatgacc ccctggaggc cactgtccat tgggccccac ctacatggcc atctcataaa      480

gttctgatct gccagttcca ctaccgaaga tgtcaggagg cggcctggac cctgctggaa      540

ccggagctga agaccatacc cctgacccct gttgagatcc aagatttgga gctagccact      600

ggctacaaag tgtatggccg ctgccggatg gagaaagaag aggatttgtg gggcgagtgg      660

agccccattt tgtccttcca gacaccgcct tctgctccaa aagatgtgtg ggtatcaggg      720

aacctctgtg ggacgcctgg aggagaggaa cctttgcttc tatggaaggc cccagggccc      780

tgtgtgcagg tgagctacaa agtctggttc tgggttggag gtcgtgagct gagtccagaa      840

ggaattacct gctgctgctc cctaattccc agtggggcgg agtgggccag ggtgtccgct      900

gtcaacgcca caagctggga gcctctcacc aacctctctt tggtctgctt ggattcagcc      960

tctgcccccc gtagcgtggc agtcagcagc atcgctggga gcacggagct actggtgacc     1020

tggcaaccgg ggcctgggga accactggag catgtagtgg actgggctcg agatggggac     1080

cccctggaga aactcaactg ggtccggctt ccccctggga acctcagtgc tctgttacca     1140

gggaatttca ctgtcggggt cccctatcga atcactgtga ccgcagtctc tgcttcaggc     1200

ttggcctctg catcctccgt ctgggggttc agggaggaat tagcacccct agtggggcca     1260

acgctttggc gactccaaga tgcccctcca gggacccccg ccatagcgtg gggagaggtc     1320

ccaaggcacc agcttcgagg ccacctcacc cactacacct tgtgtgcaca gagtggaacc     1380

agcccctccg tctgcatgaa tgtgagtggc aacacacaga gtgtcaccct gcctgacctt     1440

ccttggggtc cctgtgagct gtgggtgaca gcatctacca tcgctggaca gggccctcct     1500

ggtcccatcc tccggcttca tctaccagat aacaccctga ggtggaaagt tctgccgggc     1560

atcctattct tgtggggctt gttcctgttg gggtgtggcc tgagcctggc cacctctgga     1620

aggtgctacc acctaaggca caaagtgctg ccccgctggg tctgggagaa agttcctgat     1680

cctgccaaca gcagttcagg ccagccccac atggagcaag tacctgaggc ccagcccctt     1740

ggggacttgc ccatcctgga agtggaggag atggagcccc cgccggttat ggagtcctcc     1800

cagcccgccc aggccaccgc cccgcttgac tctgggtatg agaagcactt cctgcccaca     1860

cctgaggagc tgggccttct ggggcccccc aggccacagg ttctggcctg a              1911


<210>  325
<211>  2478
<212>  DNA
<213>  Homo sapiens;

<400>  325
atggggtggc tttgctctgg gctcctgttc cctgtgagct gcctggtcct gctgcaggtg       60

gcaagctctg ggaacatgaa ggtcttgcag gagcccacct gcgtctccga ctacatgagc      120

atctctactt gcgagtggaa gatgaatggt cccaccaatt gcagcaccga gctccgcctg      180

ttgtaccagc tggtttttct gctctccgaa gcccacacgt gtatccctga gaacaacgga      240

ggcgcggggt gcgtgtgcca cctgctcatg gatgacgtgg tcagtgcgga taactataca      300

ctggacctgt gggctgggca gcagctgctg tggaagggct ccttcaagcc cagcgagcat      360

gtgaaaccca gggccccagg aaacctgaca gttcacacca atgtctccga cactctgctg      420

ctgacctgga gcaacccgta tccccctgac aattacctgt ataatcatct cacctatgca      480

gtcaacattt ggagtgaaaa cgacccggca gatttcagaa tctataacgt gacctaccta      540

gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg      600

gtgagggcct gggctcagtg ctataacacc acctggagtg agtggagccc cagcaccaag      660

tggcacaact cctacaggga gcccttcgag cagcacctcc tgctgggcgt cagcgtttcc      720

tgcattgtca tcctggccgt ctgcctgttg tgctatgtca gcatcaccaa gattaagaaa      780

gaatggtggg atcagattcc caacccagcc cgcagccgcc tcgtggctat aataatccag      840

gatgctcagg ggtcacagtg ggagaagcgg tcccgaggcc aggaaccagc caagtgccca      900

cactggaaga attgtcttac caagctcttg ccctgttttc tggagcacaa catgaaaagg      960

gatgaagatc ctcacaaggc tgccaaagag atgcctttcc agggctctgg aaaatcagca     1020

tggtgcccag tggagatcag caagacagtc ctctggccag agagcatcag cgtggtgcga     1080

tgtgtggagt tgtttgaggc cccggtggag tgtgaggagg aggaggaggt agaggaagaa     1140

aaagggagct tctgtgcatc gcctgagagc agcagggatg acttccagga gggaagggag     1200

ggcattgtgg cccggctaac agagagcctg ttcctggacc tgctcggaga ggagaatggg     1260

ggcttttgcc agcaggacat gggggagtca tgccttcttc caccttcggg aagtacgagt     1320

gctcacatgc cctgggatga gttcccaagt gcagggccca aggaggcacc tccctggggc     1380

aaggagcagc ctctccacct ggagccaagt cctcctgcca gcccgaccca gagtccagac     1440

aacctgactt gcacagagac gcccctcgtc atcgcaggca accctgctta ccgcagcttc     1500

agcaactccc tgagccagtc accgtgtccc agagagctgg gtccagaccc actgctggcc     1560

agacacctgg aggaagtaga acccgagatg ccctgtgtcc cccagctctc tgagccaacc     1620

actgtgcccc aacctgagcc agaaacctgg gagcagatcc tccgccgaaa tgtcctccag     1680

catggggcag ctgcagcccc cgtctcggcc cccaccagtg gctatcagga gtttgtacat     1740

gcggtggagc agggtggcac ccaggccagt gcggtggtgg gcttgggtcc cccaggagag     1800

gctggttaca aggccttctc aagcctgctt gccagcagtg ctgtgtcccc agagaaatgt     1860

gggtttgggg ctagcagtgg ggaagagggg tataagcctt tccaagacct cattcctggc     1920

tgccctgggg accctgcccc agtccctgtc cccttgttca cctttggact ggacagggag     1980

ccacctcgca gtccgcagag ctcacatctc ccaagcagct ccccagagca cctgggtctg     2040

gagccggggg aaaaggtaga ggacatgcca aagcccccac ttccccagga gcaggccaca     2100

gacccccttg tggacagcct gggcagtggc attgtctact cagcccttac ctgccacctg     2160

tgcggccacc tgaaacagtg tcatggccag gaggatggtg gccagacccc tgtcatggcc     2220

agtccttgct gtggctgctg ctgtggagac aggtcctcgc cccctacaac ccccctgagg     2280

gccccagacc cctctccagg tggggttcca ctggaggcca gtctgtgtcc ggcctccctg     2340

gcaccctcgg gcatctcaga gaagagtaaa tcctcatcat ccttccatcc tgcccctggc     2400

aatgctcaga gctcaagcca gacccccaaa atcgtgaact ttgtctccgt gggacccaca     2460

tacatgaggg tctcttag                                                   2478


<210>  326
<211>  1407
<212>  DNA
<213>  Homo sapiens;

<400>  326
atgctggccg tcggctgcgc gctgctggct gccctgctgg ccgcgccggg agcggcgctg       60

gccccaaggc gctgccctgc gcaggaggtg gcgagaggcg tgctgaccag tctgccagga      120

gacagcgtga ctctgacctg cccgggggta gagccggaag acaatgccac tgttcactgg      180

gtgctcagga agccggctgc aggctcccac cccagcagat gggctggcat gggaaggagg      240

ctgctgctga ggtcggtgca gctccacgac tctggaaact attcatgcta ccgggccggc      300

cgcccagctg ggactgtgca cttgctggtg gatgttcccc ccgaggagcc ccagctctcc      360

tgcttccgga agagccccct cagcaatgtt gtttgtgagt ggggtcctcg gagcacccca      420

tccctgacga caaaggctgt gctcttggtg aggaagtttc agaacagtcc ggccgaagac      480

ttccaggagc cgtgccagta ttcccaggag tcccagaagt tctcctgcca gttagcagtc      540

ccggagggag acagctcttt ctacatagtg tccatgtgcg tcgccagtag tgtcgggagc      600

aagttcagca aaactcaaac ctttcagggt tgtggaatct tgcagcctga tccgcctgcc      660

aacatcacag tcactgccgt ggccagaaac ccccgctggc tcagtgtcac ctggcaagac      720

ccccactcct ggaactcatc tttctacaga ctacggtttg agctcagata tcgggctgaa      780

cggtcaaaga cattcacaac atggatggtc aaggacctcc agcatcactg tgtcatccac      840

gacgcctgga gcggcctgag gcacgtggtg cagcttcgtg cccaggagga gttcgggcaa      900

ggcgagtgga gcgagtggag cccggaggcc atgggcacgc cttggacaga atccaggagt      960

cctccagctg agaacgaggt gtccaccccc atgcaggcac ttactactaa taaagacgat     1020

gataatattc tcttcagaga ttctgcaaat gcgacaagcc tcccagtgca agattcttct     1080

tcagtaccac tgcccacatt cctggttgct ggagggagcc tggccttcgg aacgctcctc     1140

tgcattgcca ttgttctgag gttcaagaag acgtggaagc tgcgggctct gaaggaaggc     1200

aagacaagca tgcatccgcc gtactctttg gggcagctgg tcccggagag gcctcgaccc     1260

accccagtgc ttgttcctct catctcccca ccggtgtccc ccagcagcct ggggtctgac     1320

aatacctcga gccacaaccg accagatgcc agggacccac ggagccctta tgacatcagc     1380

aatacagact acttcttccc cagatag                                         1407


<210>  327
<211>  2757
<212>  DNA
<213>  Homo sapiens;

<400>  327
atgttgacgt tgcagacttg gctagtgcaa gccttgttta ttttcctcac cactgaatct       60

acaggtgaac ttctagatcc atgtggttat atcagtcctg aatctccagt tgtacaactt      120

cattctaatt tcactgcagt ttgtgtgcta aaggaaaaat gtatggatta ttttcatgta      180

aatgctaatt acattgtctg gaaaacaaac cattttacta ttcctaagga gcaatatact      240

atcataaaca gaacagcatc cagtgtcacc tttacagata tagcttcatt aaatattcag      300

ctcacttgca acattcttac attcggacag cttgaacaga atgtttatgg aatcacaata      360

atttcaggct tgcctccaga aaaacctaaa aatttgagtt gcattgtgaa cgaggggaag      420

aaaatgaggt gtgagtggga tggtggaagg gaaacacact tggagacaaa cttcacttta      480

aaatctgaat gggcaacaca caagtttgct gattgcaaag caaaacgtga cacccccacc      540

tcatgcactg ttgattattc tactgtgtat tttgtcaaca ttgaagtctg ggtagaagca      600

gagaatgccc ttgggaaggt tacatcagat catatcaatt ttgatcctgt atataaagtg      660

aagcccaatc cgccacataa tttatcagtg atcaactcag aggaactgtc tagtatctta      720

aaattgacat ggaccaaccc aagtattaag agtgttataa tactaaaata taacattcaa      780

tataggacca aagatgcctc aacttggagc cagattcctc ctgaagacac agcatccacc      840

cgatcttcat tcactgtcca agaccttaaa ccttttacag aatatgtgtt taggattcgc      900

tgtatgaagg aagatggtaa gggatactgg agtgactgga gtgaagaagc aagtgggatc      960

acctatgaag atagaccatc taaagcacca agtttctggt ataaaataga tccatcccat     1020

actcaaggct acagaactgt acaactcgtg tggaagacat tgcctccttt tgaagccaat     1080

ggaaaaatct tggattatga agtgactctc acaagatgga aatcacattt acaaaattac     1140

acagttaatg ccacaaaact gacagtaaat ctcacaaatg atcgctatct agcaacccta     1200

acagtaagaa atcttgttgg caaatcagat gcagctgttt taactatccc tgcctgtgac     1260

tttcaagcta ctcaccctgt aatggatctt aaagcattcc ccaaagataa catgctttgg     1320

gtggaatgga ctactccaag ggaatctgta aagaaatata tacttgagtg gtgtgtgtta     1380

tcagataaag caccctgtat cacagactgg caacaagaag atggtaccgt gcatcgcacc     1440

tatttaagag ggaacttagc agagagcaaa tgctatttga taacagttac tccagtatat     1500

gctgatggac caggaagccc tgaatccata aaggcatacc ttaaacaagc tccaccttcc     1560

aaaggaccta ctgttcggac aaaaaaagta gggaaaaacg aagctgtctt agagtgggac     1620

caacttcctg ttgatgttca gaatggattt atcagaaatt atactatatt ttatagaacc     1680

atcattggaa atgaaactgc tgtgaatgtg gattcttccc acacagaata tacattgtcc     1740

tctttgacta gtgacacatt gtacatggta cgaatggcag catacacaga tgaaggtggg     1800

aaggatggtc cagaattcac ttttactacc ccaaagtttg ctcaaggaga aattgaagcc     1860

atagtcgtgc ctgtttgctt agcattccta ttgacaactc ttctgggagt gctgttctgc     1920

tttaataagc gagacctaat taaaaaacac atctggccta atgttccaga tccttcaaag     1980

agtcatattg cccagtggtc acctcacact cctccaaggc acaattttaa ttcaaaagat     2040

caaatgtatt cagatggcaa tttcactgat gtaagtgttg tggaaataga agcaaatgac     2100

aaaaagcctt ttccagaaga tctgaaatca ttggacctgt tcaaaaagga aaaaattaat     2160

actgaaggac acagcagtgg tattgggggg tcttcatgca tgtcatcttc taggccaagc     2220

atttctagca gtgatgaaaa tgaatcttca caaaacactt cgagcactgt ccagtattct     2280

accgtggtac acagtggcta cagacaccaa gttccgtcag tccaagtctt ctcaagatcc     2340

gagtctaccc agcccttgtt agattcagag gagcggccag aagatctaca attagtagat     2400

catgtagatg gcggtgatgg tattttgccc aggcaacagt acttcaaaca gaactgcagt     2460

cagcatgaat ccagtccaga tatttcacat tttgaaaggt caaagcaagt ttcatcagtc     2520

aatgaggaag attttgttag acttaaacag cagatttcag atcatatttc acaatcctgt     2580

ggatctgggc aaatgaaaat gtttcaggaa gtttctgcag cagatgcttt tggtccaggt     2640

actgagggac aagtagaaag atttgaaaca gttggcatgg aggctgcgac tgatgaaggc     2700

atgcctaaaa gttacttacc acagactgta cggcaaggcg gctacatgcc tcagtga        2757


<210>  328
<211>  3567
<212>  DNA
<213>  Homo sapiens;

<400>  328
atggtcccct gctggaacca tggcaacatc acccgctcca aggcggagga gctgctttcc       60

aggacaggca aggacgggag cttcctcgtg cgtgccagcg agtccatctc ccgggcatac      120

gcgctctgcg tgctgtatcg gaattgcgtt tacacttaca gaattctgcc caatgaagat      180

gataaattca ctgttcaggc atccgaaggc gtctccatga ggttcttcac caagctggac      240

cagctcatcg agttttacaa gaaggaaaac atggggctgg tgacccatct gcaataccct      300

gtgccgctgg aggaagagga cacaggcgac gaccctgagg aggacacaga aagtgtcgtg      360

tctccacccg agctgccccc aagaaacatc ccgctgactg ccagctcctg tgaggccaag      420

gaggttcctt tttcaaacga gaatccccga gcgaccgaga ccagccggcc gagcctctcc      480

gagacattgt tccagcgact gcaaagcatg gacaccagtg ggcttccaga agagcatctt      540

aaggccatcc aagattattt aagcactcag ctcgcccagg actctgaatt tgtgaagaca      600

gggtccagca gtcttcctca cctgaagaaa ctgaccacac tgctctgcaa ggagctctat      660

ggagaagtca tccggaccct cccatccctg gagtctctgc agaggttatt tgaccagcag      720

ctctccccgg gcctccgtcc acgtcctcag gttcctggtg aggccaatcc catcaacatg      780

gtgtccaagc tcagccaact gacaagcctg ttgtcgtcca ttgaagacaa ggtcaaggcc      840

ttgctgcacg agggtcctga gtctccgcac cggccctccc ttatccctcc agtcaccttt      900

gaggtgaagg cagagtctct ggggattcct cagaaaatgc agctcaaagt cgacgttgag      960

tctgggaaac tgatcattaa gaagtccaag gatggttctg aggacaagtt ctacagccac     1020

aagaaaatcc tgcagctcat taagtcacag aaatttctga ataagttggt gatcttggtg     1080

gaaacagaga aggagaagat cctgcggaag gaatatgttt ttgctgactc caaaaagaga     1140

gaaggcttct gccagctcct gcagcagatg aagaacaagc actcagagca gccggagccc     1200

gacatgatca ccatcttcat cggcacctgg aacatgggta acgccccccc tcccaagaag     1260

atcacgtcct ggtttctctc caaggggcag ggaaagacgc gggacgactc tgcggactac     1320

atcccccatg acatttacgt gatcggcacc caagaggacc ccctgagtga gaaggagtgg     1380

ctggagatcc tcaaacactc cctgcaagaa atcaccagtg tgacttttaa aacagtcgcc     1440

atccacacgc tctggaacat ccgcatcgtg gtgctggcca agcctgagca cgagaaccgg     1500

atcagccaca tctgtactga caacgtgaag acaggcattg caaacacact ggggaacaag     1560

ggagccgtgg gggtgtcgtt catgttcaat ggaacctcct tagggttcgt caacagccac     1620

ttgacttcag gaagtgaaaa gaaactcagg cgaaaccaaa actatatgaa cattctccgg     1680

ttcctggccc tgggcgacaa gaagctgagt ccctttaaca tcactcaccg cttcacgcac     1740

ctcttctggt ttggggatct taactaccgt gtggatctgc ctacctggga ggcagaaacc     1800

atcatccaga aaatcaagca gcagcagtac gcagacctcc tgtcccacga ccagctgctc     1860

acagagagga gggagcagaa ggtcttccta cacttcgagg aggaagaaat cacgtttgcc     1920

ccaacctacc gttttgagag actgactcgg gacaaatacg cctacaccaa gcagaaagcg     1980

acagggatga agtacaactt gccttcctgg tgtgaccgag tcctctggaa gtcttatccc     2040

ctggtgcacg tggtgtgtca gtcttatggc agtaccagcg acatcatgac gagtgaccac     2100

agccctgtct ttgccacatt tgaggcagga gtcacttccc agtttgtctc caagaacggt     2160

cccgggactg ttgacagcca aggacagatt gagtttctca ggtgctatgc cacattgaag     2220

accaagtccc agaccaaatt ctacctggag ttccactcga gctgcttgga gagttttgtc     2280

aagagtcagg aaggagaaaa tgaagaagga agtgaggggg agctggtggt gaagtttggt     2340

gagactcttc caaagctgaa gcccattatc tctgaccctg agtacctgct agaccagcac     2400

atcctcatca gcatcaagtc ctctgacagc gacgaatcct atggcgaggg ctgcattgcc     2460

cttcggttag aggccacaga aacgcagctg cccatctaca cgcctctcac ccaccatggg     2520

gagttgacag gccacttcca gggggagatc aagctgcaga cctctcaggg caagacgagg     2580

gagaagctct atgactttgt gaagacggag cgtgatgaat ccagtgggcc aaagaccctg     2640

aagagcctca ccagccacga ccccatgaag cagtgggaag tcactagcag ggcccctccg     2700

tgcagtggct ccagcatcac tgaaatcatc aaccccaact acatgggagt ggggcccttt     2760

gggccaccaa tgcccctgca cgtgaagcag accttgtccc ctgaccagca gcccacagcc     2820

tggagctacg accagccgcc caaggactcc ccgctggggc cctgcagggg agaaagtcct     2880

ccgacacctc ccggccagcc gcccatatca cccaagaagt ttttaccctc aacagcaaac     2940

cggggtctcc ctcccaggac acaggagtca aggcccagtg acctggggaa gaacgcaggg     3000

gacacgctgc ctcaggagga cctgccgctg acgaagcccg agatgtttga gaaccccctg     3060

tatgggtccc tgagttcctt ccctaagcct gctcccagga aggaccagga atcccccaaa     3120

atgccgcgga aggaaccccc gccctgcccg gaacccggca tcttgtcgcc cagcatcgtg     3180

ctcaccaaag cccaggaggc tgatcgcggc gaggggcccg gcaagcaggt gcccgcgccc     3240

cggctgcgct ccttcacgtg ctcatcctct gccgagggca gggcggccgg cggggacaag     3300

agccaaggga agcccaagac cccggtcagc tcccaggccc cggtgccggc caagaggccc     3360

atcaagcctt ccagatcgga aatcaaccag cagaccccgc ccaccccgac gccgcggccg     3420

ccgctgccag tcaagagccc ggcggtgctg cacctccagc actccaaggg ccgcgactac     3480

cgcgacaaca ccgagctccc gcatcacggc aagcaccggc cggaggaggg gccaccaggg     3540

cctctaggca ggactgccat gcagtga                                         3567


<210>  329
<211>  2892
<212>  DNA
<213>  Homo sapiens;

<400>  329
atgtggtgcc tgcactgcaa ctcggagagg acccagtccc ttctggagct agagcttgac       60

agcggcgtcg agggcgaggc ccccagcagt gagactggca catccctgga cagcccctca      120

gcctaccccc agggcccctt ggtgcccggt tccagcctga gcccggatca ctacgagcac      180

acgtcagtgg gagcctatgg gctgtactcg gggccgccgg ggcaacagca gcgcacgcgg      240

aggcccaagc tgcagcactc gacctccatc ctgcgcaagc aggctgagga ggaggccatc      300

aagcgctcac gctcactctc cgagagctat gagctctcct cggacctgca ggacaagcag      360

gtggagatgc tagaacgaaa gtatgggggg cgcctggtaa cccgccatgc ggcccgcacc      420

atccagacgg cgtttcgcca gtaccagatg aacaagaact tcgagcgctt gcgcagctcc      480

atgtcagaga accgcatgtc acgccggatt gtgctgtcca acatgaggat gcagttctcc      540

tttgaggggc ctgagaaagt gcacagctcc tacttcgagg ggaagcaggt ctcagtgact      600

aacgacggct cccagctggg agccctggtg tcccctgagt gtggtgacct cagcgagccc      660

accaccctca agtctccggc cccctccagt gactttgcgg acgccatcac cgagctggag      720

gacgccttct ctaggcaagt gaaatcactg gccgagtcca tcgacgatgc cctcaactgc      780

cgcagcctgc acactgagga ggcaccggcc ctggatgcgg cgcgggcccg ggacaccgaa      840

ccccagacag ccctgcacgg catggaccac cgcaaactgg acgagatgac ggcctcgtac      900

agtgatgtca ccctgtacat cgatgaggag gagctgtcgc cccctctgcc cctctcgcag      960

gcaggggacc ggccgtccag caccgagtcg gacctgcggc tacgggctgg gggcgcagcc     1020

ccagactact gggccctggc ccacaaagag gacaaggctg acacggacac gagctgccgg     1080

agcacgccgt cgctggagcg gcaggagcag cggctgcggg tggagcatct gccgctgctc     1140

accatcgagc cacccagcga cagctctgtg gaccttagtg accgctcgga gcgggggtca     1200

ctcaagaggc agagtgctta cgagcgcagc cttggcgggc agcagggcag tcccaagcat     1260

ggtccccaca gcggcgcccc caagagcctc ccccgggagg agcctgagtt gcggccccgg     1320

ccccccaggc ccctggacag ccacttggcc atcaatggct cagccaaccg gcagagcaag     1380

tctgagtcgg actactcaga cggtgacaat gacagcatca acagcacgtc caactccaac     1440

gataccatca actgcagctc cgagtcatcg tcccgtgaca gcctgcggga gcagacgctc     1500

agcaagcaga cctaccacaa ggaggcccgc aacagctggg actcgcctgc ctttagcaac     1560

gatgtcatcc gcaagaggca ctaccgcatc ggcctgaacc tcttcaacaa gaagcctgag     1620

aagggagtcc agtacctcat cgagcgtggc tttgtgcccg acacgcccgt cggggtggcc     1680

cacttcctgc tgcagcgcaa gggcctcagc cggcagatga tcggcgagtt cctgggcaac     1740

cggcagaagc agttcaaccg tgacgtgctc gactgcgtcg tggacgagat ggacttctct     1800

accatggagc tggatgaggc cctcaggaaa ttccaggcgc acatccgtgt ccaaggggag     1860

gctcagaaag tggagcggct catagaggcg ttcagccagc gctactgcat ctgcaaccct     1920

ggggtggtgc ggcaattccg gaacccagac accattttca tcctggcctt cgccatcatc     1980

ctgctgaaca ccgacatgta cagccccaat gtcaagcccg agcggaaaat gaagctagag     2040

gacttcatca agaacctccg aggtgtggac gatggtgagg acattccccg tgagatgctg     2100

atggggatct atgaacggat ccgtaagcga gagctaaaga ccaatgagga ccatgtgtcc     2160

caggtgcaga aggtggagaa gctcattgtg gggaaaaagc cgatcggatc cctgcatccc     2220

gggctcggct gtgtgctctc tctgccccac cgtcggttgg tctgctactg ccggctcttt     2280

gaggttccag acccaaacaa gccccagaaa ctcggactac accagcgaga aatcttcctg     2340

ttcaacgacc tcctggtggt caccaagatc ttccagaaga agaagaactc ggtgacgtac     2400

agcttccgac agtccttctc cttgtacggc atgcaggtcc tgctcttcga gaaccagtac     2460

taccccaatg gcatccggct cacctcgtct gtccccggag cagatatcaa agtgttaata     2520

aacttcaacg cccccaaccc tcaagaccgg aagaaattca ccgatgacct gcgggagtcc     2580

attgcggaag tccaagagat ggagaagcac aggatagagt cggagctcga gaagcagaaa     2640

ggcgtcgtgc ggcccagcat gtcccagtgc tctagcctca aaaaggagtc gggcaacgga     2700

acactgagcc gggcctgcct ggacgacagc tatgccagcg gtgagggcct caagcgcagc     2760

gccctcagca gctccctgcg ggacctctcg gaagccggga agcgagggcg tcgcagcagt     2820

gcgggatcgc tagagagcaa tgtggaattt cagcctttcg agccactgca gccgtcagtg     2880

ctgtgctcct aa                                                         2892


<210>  330
<211>  498
<212>  DNA
<213>  Homo sapiens;

<400>  330
atgggctggg acctgacggt gaagatgctg gcgggcaacg aattccaggt gtccctgagc       60

agctccatgt cggtgtcaga gctgaaggcg cagatcaccc agaagatcgg cgtgcacgcc      120

ttccagcagc gtctggctgt ccacccgagc ggtgtggcgc tgcaggacag ggtccccctt      180

gccagccagg gcctgggccc cggcagcacg gtcctgctgg tggtggacaa atgcgacgaa      240

cctctgagca tcctggtgag gaataacaag ggccgcagca gcacctacga ggtacggctg      300

acgcagaccg tggcccacct gaagcagcaa gtgagcgggc tggagggtgt gcaggacgac      360

ctgttctggc tgaccttcga ggggaagccc ctggaggacc agctcccgct gggggagtac      420

ggcctcaagc ccctgagcac cgtgttcatg aatctgcgcc tgcggggagg cggcacagag      480

cctggcgggc ggagctaa                                                    498


<210>  331
<211>  3492
<212>  DNA
<213>  Homo sapiens;

<400>  331
atgaccagga ccagggcagc actcctcctg ttcacagcct tagcaacttc tctaggtttc       60

aacttggaca cagaggagct gacagccttc cgtgtggaca gcgctgggtt tggagacagc      120

gtggtccagt atgccaactc ctgggtggtg gttggagccc cccaaaagat aacagctgcc      180

aaccaaacgg gtggcctcta ccagtgtggc tacagcactg gtgcctgtga gcccatcggc      240

ctgcaggtgc ccccggaggc cgtgaacatg tccctgggcc tgtccctggc gtctaccacc      300

agcccttccc agctgctggc ctgcggcccc accgtgcacc acgagtgcgg gaggaacatg      360

tacctcaccg gactctgctt cctcctgggc cccacccagc tcacccagag gctcccggtg      420

tccaggcagg agtgcccaag acaggagcag gacattgtgt tcctgatcga tggctcaggc      480

agcatctcct cccgcaactt tgccacgatg atgaacttcg tgagagctgt gataagccag      540

ttccagagac ccagcaccca gttttccctg atgcagttct ccaacaaatt ccaaacacac      600

ttcactttcg aggaattcag gcgcagctca aaccccctca gcctgttggc ttctgttcac      660

cagctgcaag ggtttacata cacggccacc gccatccaaa atgtcgtgca ccgattgttc      720

catgcctcat atggggcccg tagggatgcc gccaaaattc tcattgtcat cactgatggg      780

aagaaagaag gcgacagcct ggattataag gatgtcatcc ccatggctga tgcagcaggc      840

atcatccgct atgcaattgg ggttggatta gcttttcaaa acagaaattc ttggaaagaa      900

ttaaatgaca ttgcatcgaa gccctcccag gaacacatat ttaaagtgga ggactttgat      960

gctctgaaag atattcaaaa ccaactgaag gagaagatct ttgccattga gggtacggag     1020

accacaagca gtagctcctt cgaattggag atggcacagg agggcttcag cgctgtgttc     1080

acacctgatg gccccgttct gggggctgtg gggagcttca cctggtctgg aggtgccttc     1140

ctgtaccccc caaatatgag ccctaccttc atcaacatgt ctcaggagaa tgtggacatg     1200

agggactctt acctgggtta ctccaccgag ctggccctct ggaaaggggt gcagagcctg     1260

gtcctggggg ccccccgcta ccagcacacc gggaaggctg tcatcttcac ccaggtgtcc     1320

aggcaatgga ggatgaaggc cgaagtcacg gggactcaga tcggctccta cttcggggcc     1380

tccctctgct ccgtggacgt agacagcgac ggcagcaccg acctggtcct catcggggcc     1440

ccccattact acgagcagac ccgagggggc caggtgtctg tgtgtccctt gcccaggggg     1500

tggagaaggt ggtggtgtga tgctgttctc tacggggagc agggccaccc ctggggtcgc     1560

tttggggcgg ctctgacagt gctgggggat gtgaatgggg acaagctgac agacgtggtc     1620

atcggggccc caggagagga ggagaaccgg ggtgctgtct acctgtttca cggagtcttg     1680

ggacccagca tcagcccctc ccacagccag cggatcgcgg gctcccagct ctcctccagg     1740

ctgcagtatt ttgggcaggc actgagcggg ggtcaagacc tcacccagga tggactggtg     1800

gacctggctg tgggggcccg gggccaggtg ctcctgctca ggaccagacc tgtgctctgg     1860

gtgggggtga gcatgcagtt catacctgcc gagatcccca ggtctgcgtt tgagtgtcgg     1920

gagcaggtgg tctctgagca gaccctggta cagtccaaca tctgccttta cattgacaaa     1980

cgttctaaga acctgcttgg gagccgtgac ctccaaagct ctgtgacctt ggacctggcc     2040

ctcgaccctg gccgcctgag tccccgtgcc accttccagg aaacaaagaa ccggagtctg     2100

agccgagtcc gagtcctcgg gctgaaggca cactgtgaaa acttcaacct gctgctcccg     2160

agctgcgtgg aggactctgt gacccccatt accttgcgtc tgaacttcac gctggtgggc     2220

aagcccctcc ttgccttcag aaacctgcgg cctatgctgg ccgccgatgc tcagagatac     2280

ttcacggcct ccctaccctt tgagaagaac tgtggagccg accatatctg ccaggacaat     2340

ctcggcatct ccttcagctt cccaggcttg aagtccctgc tggtggggag taacctggag     2400

ctgaacgcag aagtgatggt gtggaatgac ggggaagact cctacggaac caccatcacc     2460

ttctcccacc ccgcaggact gtcctaccgc tacgtggcag agggccagaa acaagggcag     2520

ctgcgttccc tgcacctgac atgtgacagc gccccagttg ggagccaggg cacctggagc     2580

accagctgca gaatcaacca cctcatcttc cgtggcggcg cccagatcac cttcttggct     2640

acctttgacg tctcccccaa ggctgtcctg ggagaccggc tgcttctgac agccaatgtg     2700

agcagtgaga acaacactcc caggaccagc aagaccacct tccagctgga gctcccggtg     2760

aagtatgctg tctacactgt ggttagcagc cacgaacaat tcaccaaata cctcaacttc     2820

tcagagtctg aggagaagga aagccatgtg gccatgcaca gataccaggt caataacctg     2880

ggacagaggg acctgcctgt cagcatcaac ttctgggtgc ctgtggagct gaaccaggag     2940

gctgtgtgga tggatgtgga ggtctcccac ccccagaacc catcccttcg gtgctcctca     3000

gagaaaatcg cacccccagc atctgacttc ctggcgcaca ttcagaagaa tcccgtgctg     3060

gactgctcca ttgctggctg cctgcggttc cgctgtgacg tcccctcctt cagcgtccag     3120

gaggagctgg atttcaccct gaagggcaac ctcagctttg gctgggtccg ccagatattg     3180

cagaagaagg tgtcggtcgt gagtgtggct gaaattacgt tcgacacatc cgtgtactcc     3240

cagcttccag gacaggaggc atttatgaga gctcagacga caacggtgct ggagaagtac     3300

aaggtccaca accccacccc cctcatcgta ggcagctcca ttgggggtct gttgctgctg     3360

gcactcatca cagcggtact gtacaaagtt ggcttcttca agcgtcagta caaggaaatg     3420

atggaggagg caaatggaca aattgcccca gaaaacggga cacagacccc cagcccgccc     3480

agtgagaaat ga                                                         3492


<210>  332
<211>  2310
<212>  DNA
<213>  Homo sapiens;

<400>  332
atgctgggcc tgcgcccccc actgctcgcc ctggtggggc tgctctccct cgggtgcgtc       60

ctctctcagg agtgcacgaa gttcaaggtc agcagctgcc gggaatgcat cgagtcgggg      120

cccggctgca cctggtgcca gaagctgaac ttcacagggc cgggggatcc tgactccatt      180

cgctgcgaca cccggccaca gctgctcatg aggggctgtg cggctgacga catcatggac      240

cccacaagcc tcgctgaaac ccaggaagac cacaatgggg gccagaagca gctgtcccca      300

caaaaagtga cgctttacct gcgaccaggc caggcagcag cgttcaacgt gaccttccgg      360

cgggccaagg gctaccccat cgacctgtac tatctgatgg acctctccta ctccatgctt      420

gatgacctca ggaatgtcaa gaagctaggt ggcgacctgc tccgggccct caacgagatc      480

accgagtccg gccgcattgg cttcgggtcc ttcgtggaca agaccgtgct gccgttcgtg      540

aacacgcacc ctgataagct gcgaaaccca tgccccaaca aggagaaaga gtgccagccc      600

ccgtttgcct tcaggcacgt gctgaagctg accaacaact ccaaccagtt tcagaccgag      660

gtcgggaagc agctgatttc cggaaacctg gatgcacccg agggtgggct ggacgccatg      720

atgcaggtcg ccgcctgccc ggaggaaatc ggctggcgca acgtcacgcg gctgctggtg      780

tttgccactg atgacggctt ccatttcgcg ggcgacggga agctgggcgc catcctgacc      840

cccaacgacg gccgctgtca cctggaggac aacttgtaca agaggagcaa cgaattcgac      900

tacccatcgg tgggccagct ggcgcacaag ctggctgaaa acaacatcca gcccatcttc      960

gcggtgacca gtaggatggt gaagacctac gagaaactca ccgagatcat ccccaagtca     1020

gccgtggggg agctgtctga ggactccagc aatgtggtcc atctcattaa gaatgcttac     1080

aataaactct cctccagggt cttcctggat cacaacgccc tccccgacac cctgaaagtc     1140

acctacgact ccttctgcag caatggagtg acgcacagga accagcccag aggtgactgt     1200

gatggcgtgc agatcaatgt cccgatcacc ttccaggtga aggtcacggc cacagagtgc     1260

atccaggagc agtcgtttgt catccgggcg ctgggcttca cggacatagt gaccgtgcag     1320

gttcttcccc agtgtgagtg ccggtgccgg gaccagagca gagaccgcag cctctgccat     1380

ggcaagggct tcttggagtg cggcatctgc aggtgtgaca ctggctacat tgggaaaaac     1440

tgtgagtgcc agacacaggg ccggagcagc caggagctgg aaggaagctg ccggaaggac     1500

aacaactcca tcatctgctc agggctgggg gactgtgtct gcgggcagtg cctgtgccac     1560

accagcgacg tccccggcaa gctgatatac gggcagtact gcgagtgtga caccatcaac     1620

tgtgagcgct acaacggcca ggtctgcggc ggcccgggga gggggctctg cttctgcggg     1680

aagtgccgct gccacccggg ctttgagggc tcagcgtgcc agtgcgagag gaccactgag     1740

ggctgcctga acccgcggcg tgttgagtgt agtggtcgtg gccggtgccg ctgcaacgta     1800

tgcgagtgcc attcaggcta ccagctgcct ctgtgccagg agtgccccgg ctgcccctca     1860

ccctgtggca agtacatctc ctgcgccgag tgcctgaagt tcgaaaaggg cccctttggg     1920

aagaactgca gcgcggcgtg tccgggcctg cagctgtcga acaaccccgt gaagggcagg     1980

acctgcaagg agagggactc agagggctgc tgggtggcct acacgctgga gcagcaggac     2040

gggatggacc gctacctcat ctatgtggat gagagccgag agtgtgtggc aggccccaac     2100

atcgccgcca tcgtcggggg caccgtggca ggcatcgtgc tgatcggcat tctcctgctg     2160

gtcatctgga aggctctgat ccacctgagc gacctccggg agtacaggcg ctttgagaag     2220

gagaagctca agtcccagtg gaacaatgat aatccccttt tcaagagcgc caccacgacg     2280

gtcatgaacc ccaagtttgc tgagagttag                                      2310


<210>  333
<211>  2841
<212>  DNA
<213>  Homo sapiens;

<400>  333
atggctgtgt actgctatgc gctcaatagc ctggtgatca tgaatagcgc caacgagatg       60

aagagcggcg gcggcccggg gcccagtggc agcgagacgc ccccgccccc gaggagggca      120

gtgctgagcc ccggcagcgt tttcagcccc gggagaggcg cctctttcct cttcccccca      180

gccgagtcgc tgtcccccga ggagccccgg agccccgggg gctggcggag cggccggcgc      240

aggctgaata gtagcagcgg cagtggcagc ggcagcagcg gcagtagcgt gagcagccca      300

agttgggctg gtcgcctgcg aggggaccgg cagcaggtgg tggcagccgg taccctctcc      360

ccgccagggc cggaggaggc caagaggaag ctgcggatct tgcagcgcga gttgcagaac      420

gtgcaggtga accagaaagt gggcatgttt gaggcgcaca tccaggcaca gagctccgcc      480

attcaagcgc cccgcagccc gcgtttgggc agggctcgct cgccctcccc gtgccccttc      540

cgcagcagca gtcagccccc tggaagggtc ctggttcagg gcgcccggag cgaggaacgg      600

aggacaaagt cctgggggga gcaatgtcca gagacttcag gaaccgactc cgggaggaaa      660

ggagggccca gcctatgctc ctcgcaggtg aagaaaggaa tgccacctct tcccggccgg      720

gctgccccta caggatcaga ggctcagggt ccatccgctt ttgtaaggat ggagaagggt      780

atccctgcca gtccccgctg tggctcaccc acagctatgg aaattgacaa aaggggctct      840

cctaccccgg gaactcggag ctgcctagct ccctcattgg ggctgttcgg agctagctta      900

acgatggcca cggaagtggc agcgagagtt acatccactg ggccacaccg tccacaggat      960

cttgccctca ctgagccgtc tgggagagcc cgtgagcttg aggacctgca gcccccagag     1020

gccctggtgg agaggcaggg gcagtttctg ggcagtgaga caagcccagc cccagaaagg     1080

ggcgggcccc gcgatggaga accccctggg aagatgggga aaggatatct gccctgtggc     1140

atgccgggct ctggggagcc tgaagtgggc aaaaggccag aggagacgac tgtgagcgtg     1200

caaagcgcag agtcctctga ttccctgagc tggtccaggc tgcccagggc cctggcctcc     1260

gtaggccctg aggaggcccg aagtggggcc cccgtgggcg gggggcgttg gcagctctcc     1320

gacagagtgg agggagggtc cccaacgctg ggcttgcttg ggggcagccc ctcagcacag     1380

ccggggaccg ggaatgtgga ggcgggaatt ccttctggca gaatgctgga gcctttgccc     1440

tgttgggacg ctgcgaaaga tctgaaagaa cctcagtgcc ctcctgggga cagggtgggt     1500

gtgcagcctg ggaactccag ggtttggcag ggcaccatgg agaaagccgg tttggcttgg     1560

acgcgtggca caggggtgca atcagagggg acttgggaaa gccagcggca ggacagtgat     1620

gccctcccaa gtccggagct gctaccccaa gatccggaca agcctttcct gaggaaggcc     1680

tgcagcccca gcaacatacc tgctgtcatc attacagaca tgggcaccca ggaggatggg     1740

gccttggagg agacgcaggg aagccctcgg ggcaacctgc ccctgaggaa actgtcctct     1800

tcctcggcct cctccacggg cttctcctca tcctacgaag actcagagga ggacatctcc     1860

agtgaccctg agcgcaccct ggaccccaac tcagccttcc tgcataccct ggaccagcag     1920

aaacctagag tgagcaaatc atggaggaag ataaaaaaca tggtgcactg gtctcccttc     1980

gtcatgtcct tcaagaagaa gtacccctgg atccagctgg caggacacgc agggagtttc     2040

aaggcagctg ccaatggcag gatcctgaag aagcactgtg agtcagagca gcgctgcctg     2100

gaccggctga tggtggatgt gctgaggccc ttcgtacctg cctaccatgg ggatgtggtg     2160

aaggacgggg agcgctacaa ccagatggac gacctgctgg ccgacttcga ctcgccctgt     2220

gtgatggact gcaagatggg aatcaggacc tacctggagg aggagctcac gaaggcccgg     2280

aagaagccca gcctgcggaa ggacatgtac cagaagatga tcgaggtgga ccccgaggcc     2340

cccaccgagg aggaaaaagc acagcgggct gtgaccaagc cacggtacat gcagtggcgg     2400

gagaccatca gctccacggc caccctgggg ttcaggatcg agggaatcaa gaaagaagac     2460

ggcaccgtga accgggactt caagaagacc aaaacgaggg agcaggtcac cgaggccttc     2520

agagagttca ctaaaggaaa ccataacatc ctgatcgcct atcgggaccg gctgaaggcc     2580

attcgaacca ctctagaagt ttctcccttc ttcaagtgcc acgaggtcat tggcagctcc     2640

ctcctcttca tccacgacaa gaaggaacag gccaaagtgt ggatgatcga ctttgggaaa     2700

accacgcccc tgcctgaggg ccagaccctg cagcatgacg tcccctggca ggaggggaac     2760

cgggaggatg gctacctctc ggggctcaat aacctcgtcg acatcctgac cgagatgtcc     2820

caggatgccc cactcgcctg a                                               2841


<210>  334
<211>  5094
<212>  DNA
<213>  Homo sapiens;

<400>  334
atgatggctc agtttcccac agctatgaat ggagggccaa acatgtgggc tattacctct       60

gaagaacgta ctaagcatga caggcagttt gataacctca aaccttcagg aggttacata      120

acaggtgatc aagcacgtaa ttttttccta caatcaggtc tgccggcccc tgttttagct      180

gaaatatggg ctttatcaga cctaaacaag gatgggaaga tggatcagca agagttctcc      240

atagctatga aactcatcaa actgaagctt caaggccaac agttgcctgt ggttctccct      300

cctattatga agcaaccccc tatgttttct ccattaattt ctgctcgttt tggaatggga      360

agcatgccca atctgtccat tcctcagcca ttgcctccag ctgcacctat aacatcattg      420

tcttctgcga cttcagggac caaccttcct cccttaatga tgcccactcc cctagtgcct      480

tctgttagca catcatcatt accaaatgga accgccagtc tcattcagcc tttacccatt      540

ccttattctt cttcaacatt gcctcatggg tcatcttata gtctgatgat gggaggattt      600

ggaggtgcta gtatacagaa agcgcagtct ctgattgatt taggatctag tagctcaact      660

tcctcgactg cttcactctc agggaactca cccaagactg ggacctcaga gtgggcagtt      720

cctcagccta caagattaaa atatcggcaa aaatttaata ctcttgacaa aagtatgagt      780

ggatatctct caggttttca agctagaaat gcccttcttc agtcaaatct ttctcaaact      840

cagctggcta ctatttggac tctggctgac gttgatggtg atggacagct aaaagcagaa      900

gagtttattc ttgcaatgca ccttactgac atggccaaag ctggacagcc attaccactg      960

actttacctc ctgagcttgt tcctccatct ttcagaggag gaaagcaaat tgattccatt     1020

aatggaactc tgccttcata tcagaaaatg caagaagagg agcctcagaa gaaattacca     1080

gttacttttg aggacaaacg gaaagccaac tatgagcgag ggaacatgga gctggaaaag     1140

cgacgccaag ccttgatgga gcagcaacaa agggaggcag aacgtaaagc ccagaaagaa     1200

aaggaagagt gggaacgaaa acagagagaa ttacaagaac aagaatggaa gaaacaactt     1260

gaattagaaa aacgcttaga gaagcaacgg gaattggaga gacaacgaga ggaagaaagg     1320

agaaaagaca tagaaagacg agaggcagca aaacaggaac ttgaacgaca acgtcgctta     1380

gaatgggaga gaattcggcg acaggagctt ctcaatcaaa agaatagaga acaagaagaa     1440

attgtcaggt taaactctaa aaagaagaat cttcatcttg agttggaagc actgaatggc     1500

aaacatcagc agatctcagg cagacttcag gatgtccgac tcaaaaagca aactcaaaag     1560

actgagctgg aagttctgga taagcagtgt gacttggaaa ttatggaaat caagcaactt     1620

caacaggaac ttcaggaata tcagaataag cttatctatc tggtacctga gaagcaatta     1680

ttaaatgaaa gaattaaaaa catgcagttc agtaacacac ctgattcagg ggtcagttta     1740

cttcataaaa aatcattaga aaaggaagaa ttatgccaaa gacttaaaga acagttagat     1800

gctcttgaaa aagaaactgc atctaagctg tcagaaatgg attcttttaa caatcaacta     1860

aagtgtggga atatggatga ctctgttctt cagtgccttt tgtctctgct aagctgtctc     1920

aacaacctct tcctcttact taaggaactg agagaaacct acaacacaca gcagttagcc     1980

cttgaacagc tttataagat caaacgtgac aagttgaagg aaattgaaag gaaaagatta     2040

gaactaatgc agaaaaagaa actagaagat gaggctgcaa ggaaagcaaa gcaaggaaaa     2100

gaaaacttat ggaaagaaaa tcttagaaag gaggaagaag aaaaacaaaa gcgactccag     2160

gaagaaaaaa cacaagaaaa aattcaagaa gaggaacgga aagctgagga gaaacaacgt     2220

aaggataagg atactttgaa agctgaggag aaaaaacgtg agacagctag tgttttggtg     2280

aattatagag cattataccc ctttgaagca aggaaccatg atgagatgag ttttaattct     2340

ggagatataa ttcaggttga tgaaaaaacc gtaggagaac ctggttggct ttatggtagt     2400

tttcaaggaa attttggctg gtttccatgc aattatgtag aaaaaatgcc atcaagtgaa     2460

aatgaaaaag ctgtatctcc aaagaaggcc ttacttcctc ctacagtttc tttatctgct     2520

acctcaactt cctctgaacc actttcttca aatcaaccag catcagtgac tgattatcaa     2580

aatgtatctt tttcaaacct aactgtaaat acatcatggc agaaaaaatc agccttcact     2640

cgaactgtgt cccctggatc tgtatcacct attcatggac agggacaagt ggtagaaaac     2700

ttaaaagcac aggccctttg ttcctggact gcaaagaaag ataaccactt gaacttctca     2760

aaacatgaca ttattactgt cttggagcag caagaaaatt ggtggtttgg ggaggtgcat     2820

ggaggaagag gatggtttcc caaatcttat gtcaagatca ttcctgggag tgaagtaaaa     2880

cgggaagaac cagaagcttt gtatgcagct gtaaataaga aacctacctc ggcagcctat     2940

tcagttggag aagaatatat tgcactttat ccatattcaa gtgtggaacc tggagatttg     3000

actttcacag aaggtgaaga aatattggtg acccagaaag atggagagtg gtggacagga     3060

agtattggag atagaagtgg aatttttcca tcaaactatg tcaaaccaaa ggatcaagag     3120

agttttggga gtgctagcaa gtctggagca tcaaataaaa aacctgagat tgctcaggta     3180

acttcagcat atgttgcttc tggttctgaa caacttagcc ttgcaccagg acagttaata     3240

ttaattctaa agaaaaatac aagtgggtgg tggcaaggag agttacaggc cagaggaaaa     3300

aagcgacaga aaggatggtt tcctgccagt catgttaaac ttttgggtcc aagtagtgaa     3360

agagccacac ctgcctttca tcctgtatgt caggtgattg ctatgtatga ctatgcagca     3420

aataatgaag atgagctcag tttctccaag ggacaactca ttaatgttat gaacaaagat     3480

gatcctgatt ggtggcaagg agagatcaac ggggtgactg gtctctttcc ttcaaactac     3540

gttaagatga cgacagactc agatccaagt caacagtggt gtgctgatct gcaaaccctg     3600

gacacaatgc agccaattga gaggaaaaga cagggctata ttcatgagct gattcagacc     3660

gaagagcggt acatggctga ccttcagctc gtcgtcgagg tttttcagaa acgcatggca     3720

gagtcaggct ttctcactga aggggagatg gccctgattt ttgttaactg gaaggagctc     3780

atcatgtcca acacaaagct gctgaaggct ttgcgggtgc ggaagaagac cgggggcgag     3840

aagatgccgg tgcagatgat tggggacatc ctggccgctg agctgtccca catgcaggct     3900

tacatcaggt tctgcagctg ccagcttaat ggagcagctc tgttacagca gaagacagat     3960

gaagacacag atttcaaaga atttttaaag aagctggcat ctgacccgcg gtgtaaagga     4020

atgcccctct ccagcttcct gctgaaaccc atgcagagga tcacccgcta cccactgctc     4080

atcagaagta ttctggagaa caccccggag agccatgcag accattcctc cctaaagctg     4140

gccctcgagc gggcagagga gctgtgctct caagtgaatg agggagttcg ggagaaggaa     4200

aactcggacc gactggagtg gatccaggcg cacgtgcagt gtgaaggcct cgcggagcaa     4260

cttattttca actctctcac caactgcctg gggccccgga agctcttaca cagtgggaaa     4320

ttatacaaga ccaagagcaa caaggaactg cacggattcc tcttcaatga cttcctgctt     4380

cttacctaca tggtcaagca gtttgctgtt tcctctggct ctgagaaact tttcagctcg     4440

aagtccaatg ctcaattcaa aatgtataaa acgcccattt tcctgaatga agtcttggtg     4500

aaactgccca cagacccttc cagcgatgag cctgtcttcc acatttccca cattgatcgg     4560

gtctacaccc tccgaacaga caacattaat gagaggaccg cctgggtgca gaagatcaag     4620

gcggcgtctg agcagtacat cgacaccgag aagaagaagc gtgagaaagc ttaccaagcc     4680

cgctcccaaa agacttcagg cattgggcgc ctgatggtgc atgtcattga agctacagaa     4740

ttaaaagcct gcaaaccaaa tggaaagagc aacccatact gtgaaatcag catgggctcc     4800

cagagctaca ccaccaggac catccaggac acactcaatc ccaagtggaa ttttaactgc     4860

cagttcttta ttaaggatct ctaccaagac gtgctgtgtc tcaccctgtt tgacagagac     4920

cagttttcac cagatgattt cctgggtcgt actgaaattc cagtggcaaa aattcgaaca     4980

gaacaggaaa gcaaaggccc tatgacccgc cgactgctgc tgcatgaggt ccccaccggg     5040

gaggtctggg tccgttttga cctgcagctt tttgagcaaa aaactctcct gtag           5094


<210>  335
<211>  3465
<212>  DNA
<213>  Homo sapiens;

<400>  335
atgcagtatc taaatataaa agaggactgc aatgccatgg ctttctgtgc taaaatgagg       60

agctccaaga agactgaggt gaacctggag gcccctgagc caggggtgga agtgatcttc      120

tatctgtcgg acagggagcc cctccggctg ggcagtggag agtacacagc agaggaactg      180

tgcatcaggg ctgcacaggc atgccgtatc tctcctcttt gtcacaacct ctttgccctg      240

tatgacgaga acaccaagct ctggtatgct ccaaatcgca ccatcaccgt tgatgacaag      300

atgtccctcc ggctccacta ccggatgagg ttctatttca ccaattggca tggaaccaac      360

gacaatgagc agtcagtgtg gcgtcattct ccaaagaagc agaaaaatgg ctacgagaaa      420

aaaaagattc cagatgcaac ccctctcctt gatgccagct cactggagta tctgtttgct      480

cagggacagt atgatttggt gaaatgcctg gctcctattc gagaccccaa gaccgagcag      540

gatggacatg atattgagaa cgagtgtcta gggatggctg tcctggccat ctcacactat      600

gccatgatga agaagatgca gttgccagaa ctgcccaagg acatcagcta caagcgatat      660

attccagaaa cattgaataa gtccatcaga cagaggaacc ttctcaccag gatgcggata      720

aataatgttt tcaaggattt cctaaaggaa tttaacaaca agaccatttg tgacagcagc      780

gtgtccacgc atgacctgaa ggtgaaatac ttggctacct tggaaacttt gacaaaacat      840

tacggtgctg aaatatttga gacttccatg ttactgattt catcagaaaa tgagatgaat      900

tggtttcatt cgaatgacgg tggaaacgtt ctctactacg aagtgatggt gactgggaat      960

cttggaatcc agtggaggca taaaccaaat gttgtttctg ttgaaaagga aaaaaataaa     1020

ctgaagcgga aaaaactgga aaataaacac aagaaggatg aggagaaaaa caagatccgg     1080

gaagagtgga acaatttttc ttacttccct gaaatcactc acattgtaat aaaggagtct     1140

gtggtcagca ttaacaagca ggacaacaag aaaatggaac tgaagctctc ttcccacgag     1200

gaggccttgt cctttgtgtc cctggtagat ggctacttcc ggctcacagc agatgcccat     1260

cattacctct gcaccgacgt ggcccccccg ttgatcgtcc acaacataca gaatggctgt     1320

catggtccaa tctgtacaga atacgccatc aataaattgc ggcaagaagg aagcgaggag     1380

gggatgtacg tgctgaggtg gagctgcacc gactttgaca acatcctcat gaccgtcacc     1440

tgctttgaga agtctgagca ggtgcagggt gcccagaagc agttcaagaa ctttcagatc     1500

gaggtgcaga agggccgcta cagtctgcac ggttcggacc gcagcttccc cagcttggga     1560

gacctcatga gccacctcaa gaagcagatc ctgcgcacgg ataacatcag cttcatgcta     1620

aaacgctgct gccagcccaa gccccgagaa atctccaacc tgctggtggc tactaagaaa     1680

gcccaggagt ggcagcccgt ctaccccatg agccagctga gtttcgatcg gatcctcaag     1740

aaggatctgg tgcagggcga gcaccttggg agaggcacga gaacacacat ctattctggg     1800

accctgatgg attacaagga tgacgaagga acttctgaag agaagaagat aaaagtgatc     1860

ctcaaagtct tagaccccag ccacagggat atttccctgg ccttcttcga ggcagccagc     1920

atgatgagac aggtctccca caaacacatc gtgtacctct atggcgtctg tgtccgcgac     1980

gtggagaata tcatggtgga agagtttgtg gaagggggtc ctctggatct cttcatgcac     2040

cggaaaagcg atgtccttac cacaccatgg aaattcaaag ttgccaaaca gctggccagt     2100

gccctgagct acttggagga taaagacctg gtccatggaa atgtgtgtac taaaaacctc     2160

ctcctggccc gtgagggcat cgacagtgag tgtggcccat tcatcaagct cagtgacccc     2220

ggcatcccca ttacggtgct gtctaggcaa gaatgcattg aacgaatccc atggattgct     2280

cctgagtgtg ttgaggactc caagaacctg agtgtggctg ctgacaagtg gagctttgga     2340

accacgctct gggaaatctg ctacaatggc gagatcccct tgaaagacaa gacgctgatt     2400

gagaaagaga gattctatga aagccggtgc aggccagtga caccatcatg taaggagctg     2460

gctgacctca tgacccgctg catgaactat gaccccaatc agaggccttt cttccgagcc     2520

atcatgagag acattaataa gcttgaagag cagaatccag atattgtttc agaaaaaaaa     2580

ccagcaactg aagtggaccc cacacatttt gaaaagcgct tcctaaagag gatccgtgac     2640

ttgggagagg gccactttgg gaaggttgag ctctgcaggt atgaccccga aggggacaat     2700

acaggggagc aggtggctgt taaatctctg aagcctgaga gtggaggtaa ccacatagct     2760

gatctgaaaa aggaaatcga gatcttaagg aacctctatc atgagaacat tgtgaagtac     2820

aaaggaatct gcacagaaga cggaggaaat ggtattaagc tcatcatgga atttctgcct     2880

tcgggaagcc ttaaggaata tcttccaaag aataagaaca aaataaacct caaacagcag     2940

ctaaaatatg ccgttcagat ttgtaagggg atggactatt tgggttctcg gcaatacgtt     3000

caccgggact tggcagcaag aaatgtcctt gttgagagtg aacaccaagt gaaaattgga     3060

gacttcggtt taaccaaagc aattgaaacc gataaggagt attacaccgt caaggatgac     3120

cgggacagcc ctgtgttttg gtatgctcca gaatgtttaa tgcaatctaa attttatatt     3180

gcctctgacg tctggtcttt tggagtcact ctgcatgagc tgctgactta ctgtgattca     3240

gattctagtc ccatggcttt gttcctgaaa atgataggcc caacccatgg ccagatgaca     3300

gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc tgccgtgccc acctaactgt     3360

ccagatgagg tttatcaact tatgaggaaa tgctgggaat tccaaccatc caatcggaca     3420

agctttcaga accttattga aggatttgaa gcacttttaa aataa                     3465


<210>  336
<211>  1872
<212>  DNA
<213>  Homo sapiens;

<400>  336
atgtccactc aagacgagag gcagatcaat actgaatatg ctgtgtcatt gttggaacag       60

ttgaaactgt tttatgaaca gcagttgttt actgacatag tgttaattgt tgagggcact      120

gaattccctt gtcataagat ggttcttgca acatgtagct cttatttcag ggccatgttt      180

atgagtggac taagtgaaag caaacaaacc catgtacacc tgaggaatgt cgatgctgcc      240

accttacaga taataataac ttatgcatac acgggtaact tggcaatgaa tgacagcact      300

gtagaacagc tttatgaaac agcttgcttc ctacaggtag aagatgtgtt acaacgttgt      360

cgagaatatt taattaaaaa aataaatgca gagaattgtg tacgattgtt gagttttgct      420

gatctcttca gttgtgagga attaaaacag agtgctaaaa gaatggtgga gcacaagttc      480

actgctgtgt atcatcagga cgcgttcatg cagctgtcac atgacctact gatagatatt      540

ctcagtagtg acaatttaaa tgtagaaaag gaagaaaccg ttcgagaagc tgctatgctg      600

tggctagagt ataacacaga atcacgatcc cagtatttgt cttctgttct tagccaaatc      660

agaattgatg cactttcaga agtaacacag agagcttggt ttcaaggtct gccacccaat      720

gataagtcag tggtggttca aggtctgtat aagtccatgc ccaagttttt caaaccaaga      780

cttgggatga ctaaagagga aatgatgatt ttcattgaag catcttcaga aaatccttgt      840

agtctttact cttctgtctg ttacagcccc caagcagaaa aagtttacaa gttatgtagc      900

ccaccagctg atttgcataa ggttgggacc gttgtaactc ctgataatga tatctacata      960

gcagggggtc aagttcctct gaaaaacaca aaaacaaatc acagtaaaac aagcaaactt     1020

cagactgcct tcagaactgt gaattgcttt tattggtttg atgcacagca aaatacctgg     1080

tttccaaaga ccccaatgct ttttgtccgc ataaagccat ctttggtttg ctgtgaaggc     1140

tatatctatg caattggagg agatagcgta ggtggagaac ttaatcggag gaccgtagaa     1200

agatacgaca ctgagaaaga tgagtggacg atggtaagcc ctttaccttg tgcttggcaa     1260

tggagtgcag cagttgtggt tcatgactgc atttatgtga tgacactgaa cctcatgtac     1320

tgttattttc caaggtctga ctcatgggta gaaatggcca tgagacagac tagtaggtcc     1380

tttgcttcag ctgcagcttt tggtgataaa attttctata ttggagggtt gcatattgct     1440

accaattccg gcataagact cccctctggc actgtagatg ggtcttcagt aactgtggaa     1500

atttatgatg tgaataaaaa tgagtggaaa atggcagcca acatccctgc taagaggtac     1560

tctgacccct gtgttagagc tgttgtgatc tcaaattctc tatgtgtgtt tatgcgagaa     1620

acccacttaa atgagcgagc taaatacgtc acctaccaat atgacctgga acttgaccgg     1680

tggtctctgc ggcagcatat atctgaacgt gtactgtggg acttggggag agattttcga     1740

tgcactgtgg ggaaactcta tccatcctgc cttgaagagt ctccatggaa accaccaact     1800

tatctttttt caacggatgg gacagaagag tttgaactgg atggagaaat ggttgcacta     1860

ccacctgtat ag                                                         1872


<210>  337
<211>  4188
<212>  DNA
<213>  Homo sapiens;

<400>  337
atgtacccta tctgtacagt tgttgtggat ggtttgccat ctgaaagctc ctcaagttct       60

tatccaggcc ctgtgtctgt ttctgaaatg tctctgcttc atgctttggg tccagtgcag      120

acctggctgg gacaagagct cgagaaatgt ggcattgatg ccatgattta cactcggtat      180

gtcctcagtc ttctgctgca tgacagctat gactacgacc tgcaggaaca ggagaatgac      240

atcttcctgg gctgggaaaa aggagcttat aagaaatggg gaaagagtaa gaaaaaatgt      300

tcagatctaa ctctagaaga aatgaaaaaa caggctgctg tccagtgtct tcgatctgct      360

tctgatgaaa gctctggtat cgagacttta gtggaggagc tctgctccag actgaaagac      420

cttcagagta agcaagaaga gaagattcac aaaaagttag aggggtctcc ctctccagag      480

gcagaattat cccctccagc aaaggatcaa gtggaaatgt actatgaagc atttccacca      540

ctttctgaga aaccagtttg cctgcaagaa atcatgactg tgtggaacaa gtctaaagtc      600

tgttcttact ctagctcttc ttcatcatcc acagccccac cagctagcac agatacttcc      660

tctcctaagg actgcaacag tgaaagtgaa gtcaccaagg aaagaagcag tgaagtaccc      720

accactgtgc atgagaaaac ccagagcaaa agcaaaaacg agaaggaaaa caaatttagt      780

aatggcacaa ttgaagaaaa gcctgctttg tacaaaaagc aaatccgaca taaacctgaa      840

ggaaagattc gccctcgctc gtggtcttct ggctccagtg aagcaggctc aagttccagt      900

gggaatcagg gagaattaaa agcatccatg aagtatgtta aagtaagaca caaggcacga      960

gagattcgaa acaaaaaagg gcggaatggg caaagcaggc tttctttgaa gcacggtgaa     1020

aaggctgaaa ggaacattca tactggaagt agtagcagta gcagcagtgg ttctgtcaaa     1080

cagctgtgca agcggggtaa gagaccttta aaagaaatag ggagaaaaga tcctgggagc     1140

actgaaggaa aagacctgta catggagaat agaaaggaca cagagtataa agaggagccc     1200

ttgtggtaca ccgagccaat tgctgaatat tttgttcctc tgagcagaaa aagtaaacta     1260

gagaccacat accgaaacag acaggataca agtgatctga catcagaggc agtggaagaa     1320

ttgtctgaat cagtgcatgg tctttgtatc agcaacaata atcttcataa aacatacctc     1380

gcagcaggta ctttcattga tggtcatttt gtagaaatgc ctgcagttat aaatgaggat     1440

attgacctca ctgggacctc attatgttct ctaccagagg acaataaata cctggatgat     1500

attcatctat cagaattaac gcacttctat gaagtggata ttgatcaatc catgttggat     1560

cctggtgcct cagaaacaat gcaaggagaa agtcggattt tgaatatgat tcgacagaaa     1620

agcaaagaga acacagattt tgaggcagaa tgttgcatag tgttagatgg tatggagttg     1680

caaggggaac gtgcaatatg gacagattct accagctccg taggtgctga gggcttattc     1740

ctgcaggacc ttggcaatct ggctcagttt tgggagtgct gttcatccag ctccggtgat     1800

gctgatgggg agagttttgg aggagactct ccagttagac tctctcccat cttagacagc     1860

acagtgctca attcacacct gcttgctggc aatcaagagc tcttttcaga tattaatgaa     1920

ggatctggta taaactcttg tttttcagtg tttgaagtgc aatgcagtaa ttctgtttta     1980

ccattttctt ttgaaacact caacttggga aatgaaaata cagattctag tgctaatatg     2040

cttgggaaaa cacagtctag attgctaata tggaccaaaa atagtgcctt tgaagaaaat     2100

gaacactgtt ctaatctttc aacaagaact tgtagtccat ggtcccattc agaagaaaca     2160

cgttcagaca atgaaacatt aaatattcag tttgaagaat ccacacagtt taatgccgaa     2220

gatattaatt atgtagttcc tagagtctcg tcaaattatg tagatgaaga acttctagat     2280

tttttgcaag atgaaacttg ccagcaaaac agtagaactt taggtgagat tcctacatta     2340

gttttcaaaa aaacatctaa actagaatcc gtctgtggta ttcagctaga acaaaaaaca     2400

gaaaacaaaa attttgaaac tacacaagta tgtaatgaaa gtccacatgg agatggctac     2460

agctcagggg ttattaaaga catttggaca aagatggcag acacaaattc tgtggctaca     2520

gtagaaatag aaagaactga tgctgagttg ttttcggcag atgtaaataa ctactgctgc     2580

tgtctagatg ctgaagctga actggagacc cttcaggagc ctgataaggc tgtgcggagg     2640

tcagagtacc atctgtggga gggacagaaa gagagcctgg agaaaagagc atttgcttct     2700

agtgagctat caaacgtgga tggtggtgat tatacaacac cctctaaacc ctgggatgta     2760

gcccaagata aagaaaacac attcattctt ggaggagttt atggagaact caaaaccttc     2820

aatagtgatg gggagtgggc agtcgtacca cctagtcaca caaaaggaag tctgttacag     2880

tgtgcagctt ctgatgttgt gacgatagct ggtacagatg tctttatgac cccaggaaac     2940

agttttgctc ctgggcacag gcagttatgg aaacccttcg tgtcatttga acagaatgat     3000

cagccgaaga gtggggaaaa tgggttaaat aagggatttt cttttatctt ccatgaagac     3060

ttactaggag cttgtggcaa ctttcaagtc gaagatcctg gacttgaata ctcattttct     3120

tcctttgact taagcaatcc attttcacaa gttcttcatg tagaatgctc atttgaacct     3180

gaagggattg catctttcag ccccagtttt aaaccgaaat caatcctctg ttctgattca     3240

gacagtgaag tgtttcaccc caggatatgt ggtgttgaca gaacacaata cagggctatt     3300

cggatctctc ctcggactca ctttcgccca atttctgcat ccgaactgtc cccaggagga     3360

ggaagcgagt cagaatttga atctgagaaa gatgaagcaa atattcccat tccttctcaa     3420

gttgatatat ttgaagatcc gcaggcagat ctcaaacctt tggaagaaga tgcagagaaa     3480

gaaggccatt actatggaaa atcagagctt gagtctggaa aattccttcc caggttaaaa     3540

aaatctggga tggaaaagag tgctcagaca tcactggatt cccaggagga atcaactggg     3600

attctttcag taggaaagca aaatcagtgt ttggaatgta gcatgaatga atccctggaa     3660

atagatttag aaagctcaga agcaaattgt aaaataatgg cacaatgcga ggaagaaatt     3720

aataattttt gtggttgcaa agcaggttgt cagtttcctg cttatgaaga taatccagtt     3780

tcttcgggac agctggaaga gttccctgta ttgaacactg atatacaagg aatgaataga     3840

agtcaagaaa aacagacctg gtgggaaaaa gccttgtact ctcctctttt tcctgcatca     3900

gagtgtgaag aatgttacac aaatgccaag ggagagagtg gtttagaaga atatccagat     3960

gctaaagaga cacccagtaa tgaagagcgc ctgttagatt ttaatagggt gtcttctgtt     4020

tatgaagcaa gatgtacagg agagagagat tctggagcaa agtcagatgg cttccgcgga     4080

aagatgtgct ccagcgccag ctccacctcg gaagagacag gctcagaagg cggaggcgag     4140

tgggtgggcc ctagtgaaga ggagctcttt tctcgaactc atctctaa                  4188


<210>  338
<211>  912
<212>  DNA
<213>  Homo sapiens;

<400>  338
atgtgccatg gcaggatagc accaaagagc acctcagtgt ttgccgtggc ctccgtggga       60

catggagtgt tccttccgct agtgatcctt tgcaccctgc ttggagacgg acttgcttcc      120

gtgtgccccc taccaccgga gccagagaat ggtggctaca tctgccaccc ccggccctgc      180

agagaccccc tgacagcagg cagtgtcatc gaatacctgt gtgctgaagg ctacatgttg      240

aagggcgatt acaaatacct gacgtgtaag aatggcgagt ggaaaccagc catggagatt      300

agctgccgtc tcaacgagga taaagacacc cacacatcac ttggggtccc cacgctgtct      360

atagtggctt ctactgccag ctccgtggcg ctcattctcc tcctcgtggt gctgtttgtg      420

ctgctgcagc caaagctgaa gtctttccat catagcaggc gtgaccaggg ggtatctggg      480

gaccaggtct ccatcatggt ggatggagtc caggttgcac taccatcata cgaggaggct      540

gtatatggca gttctggtca ctgtgtgcca cctgctgacc ccagagtaca gattgtgctg      600

tcagaagggt ctgggcccag tgggaggagc gtgccaaggg agcaacagct gccggaccaa      660

ggggcctgct cctctgcagg tggagaagat gaggccccag gccagtctgg actatgtgaa      720

gcctggggct ctcgggcctc agagactgtg atggtgcatc aggcaaccac ctcttcctgg      780

gtggccggct cagggaaccg ccaactggca cacaaagaaa ctgcagattc agagaacagt      840

gacatacaaa gccttttatc cctcacgtca gaggagtaca cagatgatat tccactgttg      900

aaagaagcat ga                                                          912


<210>  339
<211>  1236
<212>  DNA
<213>  Homo sapiens;

<400>  339
atggagaccc cagaggtccc cgtgggctcg ctaatcgact ttgggcctga ggcacccacc       60

tcttctcccc tggaggcacc accccctgtg ctgcaggacg gcgatggctc cctgggggac      120

ggtgcatcag agagtgagac cactgagtct gcggacagtg agaatgacat gggcgagtcg      180

ccctcgcacc cgtcctggga ccaagaccgc cgttcctcct ccaacgagtc cttctcctcc      240

aaccagagca ccgagtctac ccaggatgaa gagaccctgg cactcaggga cttcatgcgt      300

ggctacgtgg agaagatctt ctctggaggg gaggacttgg atcaggagga gaaagccaag      360

tttggagagt actgcagcag tgaaaatgga aaaggccggg agtggtttgc tcgatacgtg      420

agtgcccagc gctgcaactc caagtgtgtc tcagaggcaa ccttctaccg cctggtgcag      480

tcttttgcag tggtgctgtt cgagtgtcat cagatggatg actttgggcc tgccaagaac      540

ctcatgacca tgtgcttcac ctactaccac atcggaaaac cacagctgct gcccccggag      600

tcccgggaga agcccgcggg cagcatcgac tcctacctga aatccgcaaa cagctggctg      660

gccgaaaaga aggacatcgc cgagcggctg ctgaagaaca cctcggccag gactgagaat      720

gtcaagggct tcttcggggg gctggagacc aagctgaagg ggcccctggc caggaggaac      780

gaggaagacg agaacaaacc ccaggagaag cggcccaggg ctgtgaccgc gtacagcccc      840

gaggacgaaa agaaggggga gaagatctac ctgtacacgc acctgaagca acagcccatc      900

tggcacactc tgaggttctg gaatgcagcc ttttttgacg ctgtccattg tgagaggaca      960

aagcgatctc ccactaccag aggggatgct ggagaggagg aggagaagag ggagaagtgg     1020

tgccacatga cccaggagga gcgcgacgac agcctccggt tcaacgagaa catcaccttc     1080

gggcagctgg gcacattcac gcacaacatg ctggcctttg gactgaacaa gaagctgtgc     1140

aatgacttcc tgaagaagca ggctgtgatt ggcaacctgg atgaagagca atacaagctg     1200

cttagtgacc acattgagca aatggccact gagtag                               1236


<210>  340
<211>  1038
<212>  DNA
<213>  Homo sapiens;

<400>  340
atgctcatgt ttgacccagt tcctgtcaag caagaggcca tggaccctgt ctcagtgtca       60

tacccatcta attacatgga atccatgaag cctaacaagt atggggtcat ctactccaca      120

ccattgcctg agaagttctt tcagacccca gaaggtctgt cgcacggaat acagatggag      180

ccagtggacc tcacggtgaa caagcggagt tcaccccctt cggctgggaa ttcgccctcc      240

tctctgaagt tcccgtcctc acaccggaga gcctcgcctg ggttgagcat gccttcttcc      300

agcccaccga taaaaaaata ctcaccccct tctccaggcg tgcagccctt cggcgtgccg      360

ctgtccatgc caccagtgat ggcagctgcc ctctcgcggc atggaatacg gagcccgggg      420

atcctgcccg tcatccagcc ggtggtggtg cagcccgtcc cctttatgta cacaagtcac      480

ctccagcagc ctctcatggt ctccttatcg gaggagatgg aaaattccag tagtagcatg      540

caagtacctg taattgaatc atatgagaag cctatatcac agaaaaaaat taaaatagaa      600

cctgggatcg aaccacagag gacagattat tatcctgaag aaatgtcacc ccccttaatg      660

aactcagtgt cccccccgca agcattgttg caagagaatc acccttcggt catcgtgcag      720

cctgggaaga gacctttacc tgtggaatcc ccggatactc aaaggaagcg gaggatacac      780

agatgtgatt atgatggatg caacaaagtg tacactaaaa gctcccactt gaaagcacac      840

agaagaacac acacaggaga aaaaccctac aaatgtacat gggaagggtg cacatggaag      900

tttgctcggt ctgatgaact aacaagacat ttccgaaaac atactggaat caaacctttc      960

cagtgcccgg actgtgaccg cagcttctcc cgttctgacc atcttgccct ccataggaaa     1020

cgccacatgc tagtctga                                                   1038


<210>  341
<211>  852
<212>  DNA
<213>  Homo sapiens;

<400>  341
atggacgtgc tccccatgtg cagcatcttc caggagctcc agatcgtgca cgagaccggc       60

tacttctcgg cgctgccgtc tctggaggag tactggcaac agacctgcct agagctggaa      120

cgttacctcc agagcgagcc ctgctatgtt tcagcctcag aaatcaaatt tgacagccag      180

gaagatctgt ggaccaaaat cattctggct cgggagaaaa aggaggaatc cgaactgaag      240

atatcttcca gtcctccaga ggacactctc atcagcccga gcttttgtta caacttagag      300

accaacagcc tgaactcaga tgtcagcagc gaatcctctg acagctccga ggaactttct      360

cccacggcca agtttacctc cgaccccatt ggcgaagttt tggtcagctc gggaaaattg      420

agctcctctg tcacctccac gcctccatct tctccggaac tgagcaggga accttctcaa      480

ctgtggggtt gcgtgcccgg ggagctgccc tcgccaggga aggtgcgcag cgggacttcg      540

gggaagccag gtgacaaggg aaatggcgat gcctcccccg acggcaggag gagggtgcac      600

cggtgccact ttaacggctg caggaaagtt tacaccaaaa gctcccactt gaaagcacac      660

cagcggacgc acacaggaga aaagccttac agatgctcat gggaagggtg tgagtggcgt      720

tttgcaagaa gtgatgagtt aaccaggcac ttccgaaagc acaccggggc caagcctttt      780

aaatgctccc actgtgacag gtgtttttcc aggtctgacc acctggccct gcacatgaag      840

aggcacctct ga                                                          852


<210>  342
<211>  909
<212>  DNA
<213>  Homo sapiens;

<400>  342
atggacgtgt tggctagtta tagtatattc caggagctac aacttgtcca cgacaccggc       60

tacttctcag ctttaccatc cctggaggag acctggcagc agacatgcct tgaattggaa      120

cgctacctac agacggagcc ccggaggatc tcagagacct ttggtgagga cttggactgt      180

ttcctccacg cttcccctcc cccgtgcatt gaggaaagct tccgtcgctt agaccccctg      240

ctgctccccg tggaagcggc catctgtgag aagagctcgg cagtggacat cttgctctct      300

cgggacaagt tgctatctga gacctgcctc agcctccagc cggccagctc ttctctagac      360

agctacacag ccgtcaacca ggcccagctc aacgcagtga cctcattaac gcccccatcg      420

tcccctgagc tcagccgcca tctggtcaaa acctcacaaa ctctctctgc cgtggatggc      480

acggtgacgt tgaaactggt ggccaagaag gctgctctca gctccgtaaa ggtgggaggg      540

gtcgcaacag ctgcagcagc cgtgacggct gcgggggccg ttaagagtgg acagagcgac      600

agtgaccaag gagggctggg ggctgaagca tgtcccgaaa acaagaagag ggttcaccgc      660

tgtcagttta acgggtgccg gaaagtttat acaaaaagct cccacttaaa ggcccaccag      720

aggactcaca caggtgagaa gccttataag tgctcatggg agggatgtga gtggcgtttt      780

gcacgaagcg atgagctcac gaggcactac aggaaacaca caggtgcaaa gcccttcaaa      840

tgcaaccact gcgacaggtg tttttccagg tctgaccatc ttgccctcca catgaagaga      900

catatctaa                                                              909


<210>  343
<211>  1782
<212>  DNA
<213>  Homo sapiens;

<400>  343
atggagacgc cgccgctgcc tcccgcatgc acaaagcagg gtcatcagaa gcctctcgat       60

tcaaaagatg ataataccga aaaacactgc ccagtgacag tgaatccttg gcatatgaag      120

aaagctttca aagtcatgaa cgaattaaga agtcaaaatt tgctgtgcga tgtcacaatt      180

gtggcagaag acatggaaat ttctgctcat agagtggtgc tggccgcctg tagtccttat      240

tttcatgcca tgtttacagg tgagatgagt gagagccgag caaagagagt tagaataaaa      300

gaggtagatg gctggaccct gaggatgcta attgattatg tttacactgc agaaattcag      360

gttacagaag aaaatgtaca ggtacttctc ccagcagctg gtctcttaca gttacaggat      420

gtgaagaaga cttgttgtga atttttggaa tcccagcttc accctgtcaa ctgcttagga      480

atccgggctt ttgctgatat gcatgcatgt accgaccttc tgaacaaggc caacacctat      540

gcagagcaac attttgcaga tgttgtactt agtgaagaat ttctcaatct tggcatcgaa      600

caagtgtgca gcttaatctc aagtgacaaa cttaccattt cttcagaaga gaaggtattt      660

gaagcagtaa tagcatgggt gaaccatgac aaggatgtga ggcaagagtt tatggcccga      720

ctgatggaac atgtacggtt acctttgctt cctcgggaat atttagttca gagggttgaa      780

gaggaagcat tggtcaagaa tagcagtgct tgcaaagatt acctcattga agcaatgaag      840

taccatttgc tgccaacaga gcagcgtata ttaatgaaga gtgtccggac ccggctgagg      900

acacccatga accttcccaa attgatggtg gtggttgggg gccaagcacc aaaggctatc      960

cggagtgtgg aatgctatga ctttaaagaa gaaaggtggc accaagtagc agagttgcct     1020

tccaggaggt gcagggcagg catggtctac atggctggac ttgtttttgc tgttggtggc     1080

tttaatggct cattaagagt tcgcactgta gattcctacg accctgtgaa ggaccagtgg     1140

accagcgttg ctaacatgag agaccggaga agcactttgg gagctgctgt gttaaatgga     1200

ttattatacg ctgtgggagg ctttgatggg agtacaggtt tgtcatctgt ggaagcatac     1260

aacataaagt ctaatgagtg gtttcatgta gctcccatga atacaaggag gagcagtgtt     1320

ggtgtgggtg ttgttggagg tttgctctat gctgtaggag gttatgatgg agcatcacgt     1380

cagtgtctta gcacagtaga atgctataat gctacaacaa atgagtggac ctatatagca     1440

gaaatgagca ccaggcggag tggagcaggt gttggtgtgt taaacaattt attgtatgct     1500

gtaggaggtc atgatggccc tttagtacga aaaagtgttg aagtatatga tcccaccact     1560

aacgcatgga gacaggttgc agatatgaac atgtgcagaa gaaatgcagg agtttgtgca     1620

gttaatggtc tgttatatgt tgttggaggg gatgatggtt cctgtaactt ggcgtcagta     1680

gaatattata acccaacaac cgataaatgg acagttgtgt catcgtgtat gagcacaggg     1740

agaagttatg caggggtcac agttattgat aaaccattat ga                        1782


<210>  344
<211>  1560
<212>  DNA
<213>  Homo sapiens;

<400>  344
atgttcttgc tgcctcttcc ggctgcgggg cgagtagtcg tccgacgtct ggccgtgaga       60

cgtttcggga gccggagtct ctccaccgca gacatgacga agggccttgt tttaggaatc      120

tattccaaag aaaaagaaga tgatgtgcca cagttcacaa gtgcaggaga gaattttgat      180

aaattgttag ctggaaagct gagagagact ttgaacatat ctggaccacc tctgaaggca      240

gggaagactc gaacctttta tggtctgcat caggacttcc ccagcgtggt gctagttggc      300

ctcggcaaaa aggcagctgg aatcgacgaa caggaaaact ggcatgaagg caaagaaaac      360

atcagagctg ctgttgcagc ggggtgcagg cagattcaag acctggagct ctcgtctgtg      420

gaggtggatc cctgtggaga cgctcaggct gctgcggagg gagcggtgct tggtctctat      480

gaatacgatg acctaaagca aaaaaagaag atggctgtgt cggcaaagct ctatggaagt      540

ggggatcagg aggcctggca gaaaggagtc ctgtttgctt ctgggcagaa cttggcacgc      600

caattgatgg agacgccagc caatgagatg acgccaacca gatttgctga aattattgag      660

aagaatctca aaagtgctag tagtaaaacc gaggtccata tcagacccaa gtcttggatt      720

gaggaacagg caatgggatc attcctcagt gtggccaaag gatctgacga gcccccagtc      780

ttcttggaaa ttcactacaa aggcagcccc aatgcaaacg aaccacccct ggtgtttgtt      840

gggaaaggaa ttacctttga cagtggtggt atctccatca aggcttctgc aaatatggac      900

ctcatgaggg ctgacatggg aggagctgca actatatgct cagccatcgt gtctgctgca      960

aagcttaatt tgcccattaa tattataggt ctggcccctc tttgtgaaaa tatgcccagc     1020

ggcaaggcca acaagccggg ggatgttgtt agagccaaaa acgggaagac catccaggtt     1080

gataacactg atgctgaggg gaggctcata ctggctgatg cgctctgtta cgcacacacg     1140

tttaacccga aggtcatcct caatgccgcc accttaacag gtgccatgga tgtagctttg     1200

ggatcaggtg ccactggggt ctttaccaat tcatcctggc tctggaacaa actcttcgag     1260

gccagcattg aaacagggga ccgtgtctgg aggatgcctc tcttcgaaca ttatacaaga     1320

caggttgtag attgccagct tgctgatgtt aacaacattg gaaaatacag atctgcagga     1380

gcatgtacag ctgcagcatt cctgaaagaa ttcgtaactc atcctaagtg ggcacattta     1440

gacatagcag gcgtgatgac caacaaagat gaagttccct atctacggaa aggcatgact     1500

gggaggccca caaggactct cattgagttc ttacttcgtt tcagtcaaga caatgcttag     1560


<210>  345
<211>  789
<212>  DNA
<213>  Homo sapiens;

<400>  345
atggaccccc gcttgtccac tgtccgccag acctgctgct gcttcaatgt ccgcatcgca       60

accaccgccc tggccatcta ccatgtgatc atgagcgtct tgttgttcat cgagcactca      120

gtagaggtgg cccatggcaa ggcgtcctgc aagctctccc agatgggcta cctcaggatc      180

gctgacctga tctccagctt cctgctcatc accatgctct tcatcatcag cctgagccta      240

ctgatcggcg tagtcaagaa ccgggagaag tacctgctgc ccttcctgtc cctgcaaatc      300

atggactatc tcctgtgcct gctcaccctg ctgggctcct acattgagct gcccgcctac      360

ctcaagttgg cctcccggag ccgtgctagc tcctccaagt tccccctgat gacgctgcag      420

ctgctggact tctgcctgag catcctgacc ctctgcagct cctacatgga agtgcccacc      480

tatctcaact tcaagtccat gaaccacatg aattacctcc ccagccagga ggatatgcct      540

cataaccagt tcatcaagat gatgatcatc ttttccatcg ccttcatcac tgtccttatc      600

ttcaaggtct acatgttcaa gtgcgtgtgg cggtgctaca gattgatcaa gtgcatgaac      660

tcggtggagg agaagagaaa ctccaagatg ctccagaagg tggtcctgcc gtcctacgag      720

gaagccctgt ctttgccatc gaagacccca gaggggggcc cagcaccacc cccatactca      780

gaggtgtga                                                              789


<210>  346
<211>  732
<212>  DNA
<213>  Homo sapiens;

<400>  346
atgagctcgg ggactgaact gctgtggccc ggagcagcgc tgctggtgct gttgggggtg       60

gcagccagtc tgtgtgtgcg ctgctcacgc ccaggtgcaa agaggtcaga gaaaatctac      120

cagcagagaa gtctgcgtga ggaccaacag agctttacgg ggtcccggac ctactccttg      180

gtcgggcagg catggccagg acccctggcg gacatggcac ccacaaggaa ggacaagctg      240

ttgcaattct accccagcct ggaggatcca gcatcttcca ggtaccagaa cttcagcaaa      300

ggaagcagac acgggtcgga ggaagcctac atagacccca ttgccatgga gtattacaac      360

tgggggcggt tctcgaagcc cccagaagat gatgatgcca attcctacga gaatgtgctc      420

atttgcaagc agaaaaccac agagacaggt gcccagcagg agggcatagg tggcctctgc      480

agaggggacc tcagcctgtc actggccctg aagactggcc ccacttctgg tctctgtccc      540

tctgcctccc cggaagaaga tgaggaatct gaggattatc agaactcagc atccatccat      600

cagtggcgcg agtccaggaa ggtcatgggg caactccaga gagaagcatc ccctggcccg      660

gtgggaagcc cagacgagga ggacggggaa ccggattacg tgaatgggga ggtggcagcc      720

acagaagcct ag                                                          732


<210>  347
<211>  1602
<212>  DNA
<213>  Homo sapiens;

<400>  347
atggcactga ggaatgtgcc ctttcgctca gaggtcctgg gctgggaccc cgacagcctt       60

gctgactatt tcaagaagct caactataag gactgtgaga aggcagtgaa gaagtaccac      120

atcgatgggg ctcgcttctt gaacctgaca gaaaatgaca tccagaagtt ccccaagctc      180

cgggtgccga ttctcagtaa gttaagtcag gaaatcaaca agaacgaaga gaggaggagc      240

atcttcacac gcaaacccca agtcccgcgg tttcctgaag agacagaaag ccacgaagag      300

gacaatgggg gctggtcgtc ctttgaagaa gacgattatg aaagtcccaa tgatgaccag      360

gatggggagg atgatggaga ctatgagtcc cccaatgagg aggaagaggc acccgtggaa      420

gatgacgcgg attatgagcc gccaccctcc aatgacgagg aagctctgca gaactccatc      480

ctgcctgcca agcctttccc caactccaac tccatgtaca tcgaccggcc cccctctggg      540

aaaacccccc agcagcctcc tgtgcccccc cagagaccga tggccgccct cccgccccca      600

ccagccggcc ggaatcactc gccactgccc ccaccccaga ccaaccacga agaacccagc      660

agaagcagaa accacaaaac ggcaaagctc cctgctcctt caatagacag aagcacgaaa      720

cctcccctag atcgttcatt agctccgttt gatagagaac ccttcacact aggaaagaaa      780

ccaccatttt ctgacaagcc ctcgattcca gcgggaaggt cactcgggga gcatttaccc      840

aagattcaaa agcctccttt accaccgacc acggaaagac atgaaaggag cagccccctg      900

ccagggaaga agccacctgt gccaaagcat ggatggggac cagacagaag agagaatgat      960

gaagatgatg tgcatcagag acctttgccc cagccagcac tacttcctat gagctccaac     1020

actttccctt caagatctac taagccaagt cccatgaacc ctctcccatc ctctcacatg     1080

cctggagcat tctcagaaag taacagcagt tttccacaga gtgcctccct gccaccatac     1140

ttctctcaag gccctagcaa cagaccacct atcagagccg aaggcagaaa cttccccttg     1200

ccacttccaa acaaacctcg gcccccatcc cccgcggagg aagagaattc attaaatgaa     1260

gagtggtacg tttcttatat tacccgacca gaggcagaag ctgctcttag aaagataaac     1320

caggatggca catttctggt cagagacagc tctaaaaaaa caacaaccaa tccatatgtc     1380

ctcatggtgt tgtacaaaga taaagtttac aacatccaga tccgttatca gaaggaaagt     1440

caagtttact tgttgggaac tggactccga gggaaagagg actttctgtc tgtgtcagat     1500

attattgact acttcaggaa aatgccactt ctgctcattg atgggaaaaa ccgaggttcc     1560

agataccagt gcacattaac gcatgctgca gggtacccat ag                        1602


<210>  348
<211>  927
<212>  DNA
<213>  Homo sapiens;

<400>  348
atggacgcgc tcaagtcggc ggggcgggcg ctgatccgga gccccagctt ggccaagcag       60

agctgggggg gcggtggccg gcaccgcaag ctgcctgaga actggacaga cacgcgggag      120

acgctgctgg aggggatgct gttcagcctc aagtacctgg gcatgacgct agtggagcag      180

cccaagggtg aggagctgtc ggccgccgcc atcaagagga tcgtggctac agctaaggcc      240

agtgggaaga agctgcagaa ggtgactctg aaggtgtcgc cacggggaat tatcctgaca      300

gacaacctca ccaaccagct cattgagaac gtgtccatat acaggatctc ctattgcaca      360

gcagacaaga tgcacgacaa ggtgtttgca tacatcgccc agagccagca caaccagagc      420

ctcgagtgcc acgccttcct ctgcaccaag cggaagatgg cacaggctgt taccctcacc      480

gtagcccagg ccttcaaagt cgcctttgag ttttggcagg tgtccaagga agagaaagag      540

aagagggaca aagccagcca agagggaggg gacgtcctgg gggcccgcca agactgcacc      600

ccctccttga agagcttggt cgccactggg aacctgctgg acttagagga gacagctaag      660

gccccgctgt ccacggtcag cgccaacacc accaacatgg acgaggtgcc gcggccacaa      720

gccttgagtg gcagcagtgt tgtctgggag ctggatgatg gcctggatga agcgttttcg      780

aggcttgccc agtctcggac aaaccctcag gtcctggaca ctggcctgac agcccaggac      840

atgcattacg cccagtgcct ctcgcctgtc gactgggaca agcctgacag cagcggcaca      900

gagcaggatg acctcttcag cttctga                                          927


<210>  349
<211>  1200
<212>  DNA
<213>  Homo sapiens;

<400>  349
atgccccaac tctccggagg aggtggcggc ggcggggggg acccggaact ctgcgccacg       60

gacgagatga tccccttcaa ggacgagggc gatcctcaga aggaaaagat cttcgccgag      120

atcagtcatc ccgaagagga aggcgattta gctgacatca agtcttcctt ggtgaacgag      180

tctgaaatca tcccggccag caacggacac gaggtggcca gacaagcaca aacctctcag      240

gagccctacc acgacaaggc cagagaacac cccgatgacg gaaagcatcc agatggaggc      300

ctctacaaca agggaccctc ctactcgagt tattccgggt acataatgat gccaaatatg      360

aataacgacc catacatgtc aaatggatct ctttctccac ccatcccgag aacatcaaat      420

aaagtgcccg tggtgcagcc atcccatgcg gtccatcctc tcacccccct catcacttac      480

agtgacgagc acttttctcc aggatcacac ccgtcacaca tcccatcaga tgtcaactcc      540

aaacaaggca tgtccagaca tcctccagct cctgatatcc ctacttttta tcccttgtct      600

ccgggtggtg ttggacagat caccccacct cttggctggc aaggtcagcc tgtatatccc      660

atcacgggtg gattcaggca accctaccca tcctcactgt cagtcgacac ttccatgtcc      720

aggttttccc atcatatgat tcccggtcct cctggtcccc acacaactgg catccctcat      780

ccagctattg taacacctca ggtcaaacag gaacatcccc acactgacag tgacctaatg      840

cacgtgaagc ctcagcatga acagagaaag gagcaggagc caaaaagacc tcacattaag      900

aagcctctga atgcttttat gttatacatg aaagaaatga gagcgaatgt cgttgctgag      960

tgtactctaa aagaaagtgc agctatcaac cagattcttg gcagaaggtg gcatgccctc     1020

tcccgtgaag agcaggctaa atattatgaa ttagcacgga aagaaagaca gctacatatg     1080

cagctttatc caggctggtc tgcaagagac aattatggta agaaaaagaa gaggaagaga     1140

gagaaactac aggaatctgc atcaggtaca ggtccaagaa tgacagctgc ctacatctga     1200


<210>  350
<211>  1401
<212>  DNA
<213>  Homo sapiens;

<400>  350
atgaccccca tcctcacggt cctgatctgt ctcgggctga gtctgggccc caggacccac       60

gtgcaggcag ggcacctccc caagcccacc ctctgggctg agccaggctc tgtgatcatc      120

cagggaagtc ctgtgaccct caggtgtcag gggagccttc aggctgagga gtaccatcta      180

tatagggaaa acaaatcagc atcctgggtt agacggatac aagagcctgg gaagaatggc      240

cagttcccca tcccatccat cacctgggaa cacgcagggc ggtatcactg tcagtactac      300

agccacaatc actcatcaga gtacagtgac cccctggagc tggtggtgac aggagcctac      360

agcaaaccca ccctctcagc tctgcccagc cctgtggtga cctcaggagg gaacgtgacc      420

ctccagtgtg tctcacaggt ggcatttgac ggcttcattc tgtgtaagga aggagaagat      480

gaacacccac aacgcctgaa ctcccattcc catgcccgtg ggtggtcctg ggccatcttc      540

tccgtgggcc ccgtgagccc gagtcgcagg tggtcgtaca ggtgctatgc ttatgactcg      600

aactctccct atgtgtggtc tctacccagt gatctcctgg agctcctggt cccaggtgtt      660

tctaagaagc catcactctc agtgcagcca ggtcctatgg tggcccctgg ggagagcctg      720

accctccagt gtgtctctga tgtcggctac gacagatttg ttctgtataa ggagggagaa      780

cgtgacttcc tccagcgccc tggttggcag ccccaggctg ggctctccca ggccaacttc      840

accctgggcc ctgtgagccc ctcccacggg ggccagtaca gatgctacag tgcacacaac      900

ctctcctccg agtggtcggc ccccagtgac cccctggaca tcctgatcac aggacagttc      960

tatgacagac cctctctctc ggtgcagccg gtccccacag tagccccagg aaagaacgtg     1020

accctgctgt gtcagtcacg ggggcagttc cacactttcc ttctgaccaa ggagggggca     1080

ggccatcccc cactgcatct gagatcagag caccaagctc agcagaacca ggctgaattc     1140

cgcatgggtc ctgtgacctc agcccacgtg gggacctaca gatgctacag ctcactcagc     1200

tccaacccct acctgctgtc tctccccagt gaccccctgg agctcgtggt ctcagcatcc     1260

ctaggccaac acccccagga ttacacagtg gagaatctca tccgcatggg tgtggctggc     1320

ttggtcctgg tggtcctcgg gattctgcta tttgaggctc agcacagcca gagaagccta     1380

caagatgcag ccgggaggtg a                                               1401


<210>  351
<211>  1899
<212>  DNA
<213>  Homo sapiens;

<400>  351
atgacgcccg ccctcacagc cctgctctgc cttgggctga gtctgggccc caggacccgc       60

gtgcaggcag ggcccttccc caaacccacc ctctgggctg agccaggctc tgtgatcagc      120

tgggggagcc ccgtgaccat ctggtgtcag gggagcctgg aggcccagga gtaccaactg      180

gataaagagg gaagcccaga gcccttggac agaaataacc cactggaacc caagaacaag      240

gccagattct ccatcccatc catgacacag caccatgcag ggagataccg ctgccactat      300

tacagctctg caggctggtc agagcccagc gaccccctgg agctggtgat gacaggattc      360

tacaacaaac ccaccctctc agccctgccc agccctgtgg tggcctcagg ggggaatatg      420

accctccgat gtggctcaca gaagggatat caccattttg ttctgatgaa ggaaggagaa      480

caccagctcc cccggaccct ggactcacag cagctccaca gtggggggtt ccaggccctg      540

ttccctgtgg gccccgtgac ccccagccac aggtggaggt tcacatgcta ttactattat      600

acaaacaccc cccgggtgtg gtcccacccc agtgaccccc tggagattct gccctcaggc      660

gtgtctagga agccctccct cctgaccctg cagggccctg tcctggcccc tgggcagagc      720

ctgaccctcc agtgtggctc tgatgtcggc tacgacagat ttgttctgta taaggagggg      780

gaacgtgact tcctccagcg ccctggccag cagccccagg ctgggctctc ccaggccaac      840

ttcaccctgg gccctgtgag cccctcccac gggggccagt acaggtgcta tggtgcacac      900

aacctctcct ccgagtggtc ggcccccagc gaccccctga acatcctgat ggcaggacag      960

atctatgaca ccgtctccct gtcagcacag ccgggcccca cagtggcctc aggagagaac     1020

gtgaccctgc tgtgtcagtc acggggttat tttgacactt tccttctgac caaagaaggg     1080

gcagcccatc ccccactgcg tctgagatca atgtacggag ctcataagta ccaggctgaa     1140

ttccccatga gtcctgtgac ctcagcccac gcggggacct acaggtgcta cggctcatac     1200

agctccaacc cccacctgct gtctttcccc agtgagcccc tggaactcat ggtctcagga     1260

cactctggag gctccagcct cccacccaca gggccgccct ccacacctgg tctgggaaga     1320

tacctggagg ttttgattgg ggtctcggtg gccttcgtcc tgctgctctt cctcctcctc     1380

ttcctcctcc tccgacgtca gcgtcacagc aaacacagga catctgacca gagaaagact     1440

gatttccagc gtcctgcagg ggctgcggag acagagccca aggacagggg cctgctgagg     1500

aggtccagcc cagctgctga cgtccaggaa gaaaacctct atgctgccgt gaaggacaca     1560

cagtctgagg acagggtgga gctggacagt cagcagagcc cacacgatga agacccccag     1620

gcagtgacgt atgccccggt gaaacactcc agtcctagga gagaaatggc ctctcctccc     1680

tcctcactgt ctggggaatt cctggacaca aaggacagac aggtggaaga ggacaggcag     1740

atggacactg aggctgctgc atctgaagcc tcccaggatg tgacctacgc ccagctgcac     1800

agcttgaccc ttagacggaa ggcaactgag cctcctccat cccaggaagg ggaacctcca     1860

gctgagccca gcatctacgc cactctggcc atccactag                            1899


<210>  352
<211>  1917
<212>  DNA
<213>  Homo sapiens;

<400>  352
atgtccgcgc tggcgggtga agatgtctgg aggtgtccag gctgtgggga ccacattgct       60

ccaagccaga tatggtacag gactgtcaac gaaacctggc acggctcttg cttccggtgt      120

tcagaatgcc aggattccct caccaactgg tactatgaga aggatgggaa gctctactgc      180

cccaaggact actgggggaa gtttggggag ttctgtcatg ggtgctccct gctgatgaca      240

gggcctttta tggtggctgg ggagttcaag taccacccag agtgctttgc ctgtatgagc      300

tgcaaggtga tcattgagga tggggatgca tatgcactgg tgcagcatgc caccctctac      360

tgtgggaagt gccacaatga ggtggtgctg gcacccatgt ttgagagact ctccacagag      420

tctgttcagg agcagctgcc ctactctgtc acgctcatct ccatgccggc caccactgaa      480

ggcaggcggg gcttctccgt gtccgtggag agtgcctgct ccaactacgc caccactgtg      540

caagtgaaag aggtcaaccg gatgcacatc agtcccaaca atcgaaacgc catccaccct      600

ggggaccgca tcctggagat caatgggacc cccgtccgca cacttcgagt ggaggaggtg      660

gaggatgcaa ttagccagac gagccagaca cttcagctgt tgattgaaca tgaccccgtc      720

tcccaacgcc tggaccagct gcggctggag gcccggctcg ctcctcacat gcagaatgcc      780

ggacaccccc acgccctcag caccctggac accaaggaga atctggaggg gacactgagg      840

agacgttccc taaggcgcag taacagtatc tccaagtccc ctggccccag ctccccaaag      900

gagcccctgc tgttcagccg tgacatcagc cgctcagaat cccttcgttg ttccagcagc      960

tattcacagc agatcttccg gccctgtgac ctaatccatg gggaggtcct ggggaagggc     1020

ttctttgggc aggctatcaa ggtgacacac aaagccacgg gcaaagtgat ggtcatgaaa     1080

gagttaattc gatgtgatga ggagacccag aaaacttttc tgactgaggt gaaagtgatg     1140

cgcagcctgg accaccccaa tgtgctcaag ttcattggtg tgctgtacaa ggataagaag     1200

ctgaacctcc tgacagagta cattgagggg ggcacactga aggactttct gcgcagtatg     1260

gatccgttcc cctggcagca gaaggtcagg tttgccaaag gaatcgcctc cggaatggcc     1320

tatttgcact ctatgtgcat catccaccgg gatctgaact cgcacaactg cctcatcaag     1380

ttggacaaga ctgtggtggt ggcagacttt gggctgtcac ggctcatagt ggaagagagg     1440

aaaagggccc ccatggagaa ggccaccacc aagaaacgca ccttgcgcaa gaacgaccgc     1500

aagaagcgct acacggtggt gggaaacccc tactggatgg cccctgagat gctgaacgga     1560

aagagctatg atgagacggt ggatatcttc tcctttggga tcgttctctg tgagatcatt     1620

gggcaggtgt atgcagatcc tgactgcctt ccccgaacac tggactttgg cctcaacgtg     1680

aagcttttct gggagaagtt tgttcccaca gattgtcccc cggccttctt cccgctggcc     1740

gccatctgct gcagactgga gcctgagagc agaccagcat tctcgaaatt ggaggactcc     1800

tttgaggccc tctccctgta cctgggggag ctgggcatcc cgctgcctgc agagctggag     1860

gagttggacc acactgtgag catgcagtac ggcctgaccc gggactcacc tccctag        1917


<210>  353
<211>  1056
<212>  DNA
<213>  Homo sapiens;

<400>  353
atggtcatca tgggccagtg ctactacaac gagaccatcg gcttcttcta taacaacagt       60

ggcaaagagc tcagctccca ctggcggccc aaggatgtgg tcgtggtggc actggggctg      120

accgtcagcg tgctggtgct gctgaccaat ctgctggtca tagcagccat cgcctccaac      180

cgccgcttcc accagcccat ctactacctg ctcggcaatc tggccgcggc tgacctcttc      240

gcgggcgtgg cctacctctt cctcatgttc cacactggtc cccgcacagc ccgactttca      300

cttgagggct ggttcctgcg gcagggcttg ctggacacaa gcctcactgc gtcggtggcc      360

acactgctgg ccatcgccgt ggagcggcac cgcagtgtga tggccgtgca gctgcacagc      420

cgcctgcccc gtggccgcgt ggtcatgctc attgtgggcg tgtgggtggc tgccctgggc      480

ctggggctgc tgcctgccca ctcctggcac tgcctctgtg ccctggaccg ctgctcacgc      540

atggcacccc tgctcagccg ctcctatttg gccgtctggg ctctgtcgag cctgcttgtc      600

ttcctgctca tggtggctgt gtacacccgc attttcttct acgtgcggcg gcgagtgcag      660

cgcatggcag agcatgtcag ctgccacccc cgctaccgag agaccacgct cagcctggtc      720

aagactgttg tcatcatcct gggggcgttc gtggtctgct ggacaccagg ccaggtggta      780

ctgctcctgg atggtttagg ctgtgagtcc tgcaatgtcc tggctgtaga aaagtacttc      840

ctactgttgg ccgaggccaa ctccctggtc aatgctgctg tgtactcttg ccgagatgct      900

gagatgcgcc gcaccttccg ccgccttctc tgctgcgcgt gcctccgcca gtccacccgc      960

gagtctgtcc actatacatc ctctgcccag ggaggtgcca gcactcgcat catgcttccc     1020

gagaacggcc acccactgat ggactccacc ctttag                               1056


<210>  354
<211>  2691
<212>  DNA
<213>  Homo sapiens;

<400>  354
atgaattatg tgggacagct ggctgggcag gtgattgtca ctgtgaagga actctacaag       60

ggcattaacc aggccaccct ctctgggtgc attgatgtca tcgtggtaca gcagcaggat      120

ggcagctatc agtgttcacc ttttcacgtt cggtttggaa agctgggagt cctgagatcc      180

aaagagaaag tgattgatat agaaatcaac ggcagtgcag tggatcttca catgaagttg      240

ggtgataacg gagaagcttt ctttgttgag gagactgaag aagaatatga aaagcttcct      300

gcttaccttg ccacctcacc aattcctact gaagatcagt tctttaaaga tattgacacc      360

cctttggtga aatcgggtgg agatgaaaca ccatctcaga gttcagacat ctcacacgtc      420

ttggaaacag agacaatttt tactccaagt tctgtgaaaa agaaaaaacg aaggagaaag      480

aaatacaaac aggacagtaa gaaggaagag caggccgcat ctgctgctgc agaagacaca      540

tgtgatgtag gcgtgagctc cgatgatgac aagggggccc aggcagcacg aggatcttca      600

aatgcttcct tgaaagaaga agaatgtaaa gagcctttgc tcttccattc tggggatcat      660

taccccttat ctgatggaga ttggtcccct ttagagacca cctatcccca gacagcgtgt      720

cctaagagtg attcagagct ggaggtgaaa cctgcggaga gcctgctcag atcagagtct      780

cacatggagt ggacgtgggg cggattccca gagtccacca aggtcagcaa aagagaacga      840

tctgaccatc atcctaggac agctacaatt acaccatcag aaaatactca ttttcgggta      900

attcccagtg aggacaacct catcagtgaa gttgagaagg atgcttccat ggaagacact      960

gtctgtacca tagtgaagcc caaacccaga gccctgggta cacagatgag cgacccaaca     1020

tctgtggcag agcttctcga acctcctctt gagagtactc agatttcatc tatgttagat     1080

gctgaccacc ttcccaacgc agccttagcg gaggcgccct cagaatccaa accggcagct     1140

aaagtagact cgccgtcaaa gaagaaaggt gttcacaaaa gaagccaaca ccagggacct     1200

gatgatattt accttgatga cttaaagggt ctagaacctg aagttgcagc tctttatttc     1260

cctaaaagtg aatcggagcc cggttccagg cagtggcccg agtctgacac actctctggc     1320

tcccagtccc cacagtccgt gggaagcgca gctgcagata gcggcaccga gtgcctctca     1380

gattctgcca tggacttgcc tgacgttacc ctctcccttt gcgggggcct cagtgaaaat     1440

ggagaaattt caaaagaaaa attcatggag catatcatta cttatcacga atttgcagaa     1500

aaccctggac ttatagacaa tcctaacctt gtaataagga tatataatcg ttactataac     1560

tgggctttgg cagctcccat gatccttagc ttgcaagtat tccagaagag cttgcctaag     1620

gccacagttg agtcctgggt gaaagacaag atgccaaaga aatctggtcg ctggtggttt     1680

tggcgaaaga gagaaagcat gaccaaacag ctgccagaat ccaaggaggg aaaatctgag     1740

gcaccgccag ccagtgacct gccatccagc tccaaggagc cggccggtgc caggccggcc     1800

gagaatgact cctcgagtga cgagggatca caggagctcg aagaatccat cacagtggac     1860

cccatcccca cagagcccct gagccacggc agcacaactt catataagaa gtctctccgc     1920

ctctcctcag accagatcgc aaaactgaag ctccacgatg gcccaaatga tgttgtgttt     1980

agtattacaa cccagtatca aggcacctgt cgctgtgcag ggaccattta cctgtggaac     2040

tggaatgaca agatcatcat ttctgatatt gatgggacaa taaccaagtc ggatgctttg     2100

ggacagattc tcccacagct gggcaaagac tggacccacc agggtatagc aaagctctac     2160

cattccatca atgagaatgg ctacaagttt ctgtactgct cggctcgtgc catcggcatg     2220

gccgacatga cccgtggcta cctgcactgg gtcaatgaca agggcacaat cttgccccgg     2280

ggccccctga tgctgtcccc cagcagcttg ttctccgcct tccacagaga agtgatagaa     2340

aagaaaccag agaagttcaa aattgagtgt ctaaatgata tcaagaatct gtttgccccg     2400

tctaagcagc ccttctatgc tgcctttgga aaccgtccaa atgatgtcta tgcctacaca     2460

caagttggag ttccagactg tagaatattc accgtgaacc ccaagggtga attaatacaa     2520

gaaagaacca aaggaaacaa gtcatcgtat cacaggctga gtgagctcgt ggagcatgtg     2580

ttcccccttc tcagtaagga gcagaattcc gcttttccct gcccggagtt cagctccttc     2640

tgctactggc gagacccgat ccctgaagtg gacctggatg acctgtcttg a              2691


<210>  355
<211>  1500
<212>  DNA
<213>  Homo sapiens;

<400>  355
atgaatgatg acccaagtat ggaagagaat ggtgttgaac gcgtgtgtcc tgagagcctg       60

ctgcagtcca gggaatattc ctcactacca ttacccagac acacttcatc gacagacggt      120

actataactt caagtgatcc tggattagaa attctgaata tggcttcttg tgaccttgac      180

agaaactcgc tctgtaagaa agaggaggat acaagatcag cttctcccac gatagaggcc      240

caaggcacaa gtccagctca tgataatatt gcattccaag actctacgag taaggataaa      300

accatattaa atctggaagc caaagaggaa ccagaaacaa tagaagaaca taaaaaagaa      360

catgcttcag gagactctgt ggtttcccct cttcctgtaa ccactgtgaa atcggttaac      420

cttagacaaa gtgagaacac ttctgctaat gagaaggagg tggaggcaga atttctcaga      480

ttatctttgg gatttaagtg tgactggttt accttggaga agagagtgaa gcttgaagag      540

aggtcccgtg acttggcaga agaaaatttg aagaaagaaa tcactaactg tttaaaacta      600

ttagagtctt taacacctct gtgtgaagat gacaaccagg cacaggaaat cattaagaag      660

ctggagaaga gtataaagtt tcttagccag tgtgcagcac gagtggccag tagggctgag      720

atgttgggag ccatcaatca ggaaagccgg gttagtaaag cagttgaagt gatgattcag      780

cacgtagaaa acttgaagag gatgtatgcc aaagagcacg ctgaattaga agaactgaaa      840

caggttcttc tgcagaatga aaggtctttc aatcctcttg aagatgatga tgactgccaa      900

attaaaaaac gttcagcttc tctaaactcc aagccatctt ctctacgaag agtgactatt      960

gcctctttac ccagaaatat tggaaatgca ggaatggtgg ctgggatgga aaataatgat     1020

cgattcagta gaaggtcaag cagttggcgt attttggggt caaagcagag tgaacaccgt     1080

ccctcattac ctcgatttat tagcacctat tcctgggcag atgctgaaga agaaaaatgt     1140

gaactaaaaa ctaaagatga ctcagagcca tctggagaag aaacagtaga aaggacaagg     1200

aagccaagtc tttctgaaaa gaaaaataat ccatcaaagt gggatgtctc ttcagtttat     1260

gacacaatag cttcctgggc aacaaatctc aagtcctcca tcagaaaggc taataaggcc     1320

ctctggctct ctattgcatt cattgtactg tttgcagctt tgatgagctt cctcacaggc     1380

caattattcc agaagtctgt ggatgccgct cccacacagc aagaggactc atggacgtct     1440

ctagaacata tcttgtggcc atttaccaga ctccgacaca atgggccacc accagtgtga     1500


<210>  356
<211>  2142
<212>  DNA
<213>  Homo sapiens;

<400>  356
atgctgttgg ccaccctcct cctcctcctc cttggaggcg ctctggccca tccagaccgg       60

attatttttc caaatcatgc ttgtgaggac cccccagcag tgctcttaga agtgcagggc      120

accttacaga ggcccctggt ccgggacagc cgcacctccc ctgccaactg cacctggctc      180

atcctgggca gcaaggaaca gactgtcacc atcaggttcc agaagctaca cctggcctgt      240

ggctcagagc gcttaaccct acgctcccct ctccagccac tgatctccct gtgtgaggca      300

cctcccagcc ctctgcagct gcccgggggc aacgtcacca tcacttacag ctatgctggg      360

gccagagcac ccatgggcca gggcttcctg ctctcctaca gccaagattg gctgatgtgc      420

ctgcaggaag agtttcagtg cctgaaccac cgctgtgtat ctgctgtcca gcgctgtgat      480

ggggttgatg cctgtggcga tggctctgat gaagcaggtt gcagctcaga ccccttccct      540

ggcctgaccc caagacccgt cccctccctg ccttgcaatg tcaccttgga ggacttctat      600

ggggtcttct cctctcctgg atatacacac ctagcctcag tctcccaccc ccagtcctgc      660

cattggctgc tggaccccca tgatggccgg cggctggccg tgcgcttcac agccctggac      720

ttgggctttg gagatgcagt gcatgtgtat gacggccctg ggccccctga gagctcccga      780

ctactgcgta gtctcaccca cttcagcaat ggcaaggctg tcactgtgga gacactgtct      840

ggccaggctg ttgtgtccta ccacacagtt gcttggagca atggtcgtgg cttcaatgcc      900

acctaccatg tgcggggcta ttgcttgcct tgggacagac cctgtggctt aggctctggc      960

ctgggagctg gcgaaggcct aggtgagcgc tgctacagtg aggcacagcg ctgtgacggc     1020

tcatgggact gtgctgacgg cacagatgag gaggactgcc caggctgccc acctggacac     1080

ttcccctgtg gggctgctgg cacctctggt gccacagcct gctacctgcc tgctgaccgc     1140

tgcaactacc agactttctg tgctgatgga gcagatgaga gacgctgtcg gcattgccag     1200

cctggcaatt tccgatgccg ggacgagaag tgcgtgtatg agacgtgggt gtgcgatggg     1260

cagccagact gtgcggacgg cagtgatgag tgggactgct cctatgttct gccccgcaag     1320

gtcattacag ctgcagtcat tggcagccta gtgtgcggcc tgctcctggt catcgccctg     1380

ggctgcacct gcaagctcta tgccattcgc acccaggagt acagcatctt tgcccccctc     1440

tcccggatgg aggctgagat tgtgcagcag caggcacccc cttcctacgg gcagctcatt     1500

gcccagggtg ccatcccacc tgtagaagac tttcctacag agaatcctaa tgataactca     1560

gtgctgggca acctgcgttc tctgctacag atcttacgcc aggatatgac tccaggaggt     1620

ggcccaggtg cccgccgtcg tcagcggggc cgcttgatgc gacgcctggt acgccgtctc     1680

cgccgctggg gcttgctccc tcgaaccaac accccggctc gggcctctga ggccagatcc     1740

caggtcacac cttctgctgc tccccttgag gccctagatg gtggcacagg tccagcccgt     1800

gagggcgggg cagtgggtgg gcaagatggg gagcaggcac ccccactgcc catcaaggct     1860

cccctcccat ctgctagcac gtctccagcc cccactactg tccctgaagc cccagggcca     1920

ctgccctcac tgcccctaga gccatcacta ttgtctggag tggtgcaggc cctgcgaggc     1980

cgcctgttgc ccagcctggg gcccccagga ccaacccgga gcccccctgg accccacaca     2040

gcagtcctgg ccctggaaga tgaggacgat gtgctactgg tgccactggc tgagccgggg     2100

gtgtgggtag ctgaggcaga ggatgagcca ctgcttacct ga                        2142


<210>  357
<211>  315
<212>  DNA
<213>  Homo sapiens;

<400>  357
atgttatcgc ggaatgatga tatatgtatc tacgggggcc tggggctggg cgggctcctg       60

cttctggcag tggtccttct gtccgcctgc ctgtgttggc tgcatcgaag agtaaagagg      120

ctggagagga gctggcacct tctgtcctgg tcccaggccc agggctcctc agagcaggaa      180

ctccactatg catctctgca gaggctgcca gtgcccagca gtgagggacc tgacctcagg      240

ggcagagaca agagaggcac caaggaggat ccaagagctg actatgcctg cattgctgag      300

aacaaaccca cctga                                                       315


<210>  358
<211>  735
<212>  DNA
<213>  Homo sapiens;

<400>  358
atgggggcac tggggctgga gggcaggggt gggaggctcc aggggagggg ttccctcctg       60

ctagctgtgg caggagccac ttctctggtg accttgttgc tggcggtgcc tatcactgtc      120

ctggctgtgc tggccttagt gccccaggat cagggaggac tggtaacgga gacggccgac      180

cccggggcac aggcccagca aggactgggg tttcagaagc tgccagagga ggagccagaa      240

acagatctca gccccgggct cccagctgcc cacctcatag gcgctccgct gaaggggcag      300

gggctaggct gggagacgac gaaggaacag gcgtttctga cgagcgggac gcagttctcg      360

gacgccgagg ggctggcgct cccgcaggac ggcctctatt acctctactg tctcgtcggc      420

taccggggcc gggcgccccc tggcggcggg gacccccagg gccgctcggt cacgctgcgc      480

agctctctgt accgggcggg gggcgcctac gggccgggca ctcccgagct gctgctcgag      540

ggcgccgaga cggtgactcc agtgctggac ccggccagga gacaagggta cgggcctctc      600

tggtacacga gcgtggggtt cggcggcctg gtgcagctcc ggaggggcga gagggtgtac      660

gtcaacatca gtcaccccga tatggtggac ttcgcgagag ggaagacctt ctttggggcc      720

gtgatggtgg ggtga                                                       735


<210>  359
<211>  843
<212>  DNA
<213>  Homo sapiens;

<400>  359
atgtgcccgc ctcaggcaca ggcagaggtg ggccccacca tgactgagaa ggcagagatg       60

gtgtgtgccc ccagcccagc gcctgcccca ccccctaagc ctgcctcgcc tgggcccccg      120

caggtggagg aggtgggcca ccgaggaggc tcctcgcccc ccaggctgcc acctggtgta      180

ccagtgatca gcctgggcca cagcaggccc ccaggggtag ccatgcccac cacagagctg      240

ggcactctgc ggcccccgct gctgcaactc tccaccctgg gaactgcccc gcccactttg      300

gccctgcact accaccctca ccccttcctc aacagtgtct acattgggcc agcaggacct      360

tttagcatct tccctagcag ccggttgaag cggagaccaa gccactgtga gctggacctg      420

gctgaggggc accagcccca gaaggtggcc cggcgcgtgt tcaccaacag ccgggagcgc      480

tggcggcagc agaacgttaa cggcgccttc gccgagctga ggaagctgct gccgacgcac      540

ccgcccgacc ggaagctgag caagaacgag gtgctccgcc tagccatgaa gtacatcggc      600

ttcctggtgc ggctgctgcg cgaccaagcc gcagctctgg ccgcaggccc cacccctccc      660

gggcctcgca aacggccggt gcaccgggtc ccagacgacg gcgcccgccg gggatccgga      720

cgcagggccg aggcggcagc gcgctcgcag cccgcgcccc cggccgaccc cgacggcagc      780

cccggtggag cggcccggcc catcaagatg gagcaaaccg ctttgagccc agaggtgcgg      840

tga                                                                    843


<210>  360
<211>  1539
<212>  DNA
<213>  Homo sapiens;

<400>  360
atgggatgta taaaatcaaa agggaaagac agcttgagtg acgatggagt agatttgaag       60

actcaaccag tacgtaatac tgaaagaact atttatgtga gagatccaac gtccaataaa      120

cagcaaaggc cagttccaga atctcagctt ttacctggac agaggtttca aactaaagat      180

ccagaggaac aaggagacat tgtggtagcc ttgtacccct atgatggcat ccacccggac      240

gacttgtctt tcaagaaagg agagaagatg aaagtcctgg aggagcatgg agaatggtgg      300

aaagcaaagt cccttttaac aaaaaaagaa ggcttcatcc ccagcaacta tgtggccaaa      360

ctcaacacct tagaaacaga agagtggttt ttcaaggata taaccaggaa ggacgcagaa      420

aggcagcttt tggcaccagg aaatagcgct ggagctttcc ttattagaga aagtgaaaca      480

ttaaaaggaa gcttctctct gtctgtcaga gactttgacc ctgtgcatgg tgatgttatt      540

aagcactaca aaattagaag tctggataat gggggctatt acatctctcc acgaatcact      600

tttccctgta tcagcgacat gattaaacat taccaaaagc aggcagatgg cttgtgcaga      660

agattggaga aggcttgtat tagtcccaag ccacagaagc catgggataa agatgcctgg      720

gagatccccc gggagtccat caagttggtg aaaaggcttg gcgctgggca gtttggggaa      780

gtctggatgg gttactataa caacagtacc aaggtggctg tgaaaaccct gaagccagga      840

actatgtctg tgcaagcctt cctggaagaa gccaacctca tgaagaccct gcagcatgac      900

aagctcgtga ggctctacgc tgtggtcacc agggaggagc ccatttacat catcaccgag      960

tacatggcca agggcagttt gctggatttc ctgaagagcg atgaaggtgg caaagtgctg     1020

cttccaaagc tcattgactt ttctgctcag attgcagagg gaatggcata catcgagcgg     1080

aagaactaca ttcaccggga cctgcgagca gctaatgttc tggtctccga gtcactcatg     1140

tgcaaaattg cagattttgg ccttgctaga gtaattgaag ataatgagta cacagcaagg     1200

gaaggtgcta agttccctat taagtggacg gctccagaag caatcaactt tggatgtttc     1260

actattaagt ctgatgtgtg gtcctttgga atcctcctat acgaaattgt cacctatggg     1320

aaaattccct acccagggag aactaatgcc gacgtgatga ccgccctgtc ccagggctac     1380

aggatgcccc gtgtggagaa ctgcccagat gagctctatg acattatgaa aatgtgctgg     1440

aaagaaaagg cagaagagag accaacgttt gactacttac agagcgtcct ggatgatttc     1500

tacacagcca cggaagggca ataccagcag cagccttag                            1539


<210>  361
<211>  11406
<212>  DNA
<213>  Homo sapiens;

<400>  361
atgagcaccg acagtaactc actggcacgt gaatttctga ccgatgtcaa ccggctttgc       60

aatgcagtgg tccagagggt ggaggccagg gaggaagaag aggaggagac gcacatggca      120

acccttggac agtaccttgt ccatggtcga ggatttctat tacttaccaa gctaaattct      180

ataattgatc aggcattgac atgtagagaa gaactcctga ctcttcttct gtctctcctt      240

ccactggtat ggaagatacc tgtccaagaa gaaaaggcaa cagattttaa cctaccgctc      300

tcagcagata taatcctgac caaagaaaag aactcaagtt cacaaagatc cactcaggaa      360

aaattacatt tagaaggaag tgccctgtct agtcaggttt ctgcaaaagt aaatgttttt      420

cgaaaaagca gacgacagcg taaaattacc catcgctatt ctgtaagaga tgcaagaaag      480

acacagctct ccacctcaga ttcagaagcc aattcagatg aaaaaggcat agcaatgaat      540

aagcatagaa ggccccatct gctgcatcat tttttaacat cgtttcctaa acaagaccac      600

cccaaagcta aacttgaccg cttagcaacc aaagaacaga ctcctccaga tgctatggct      660

ttggaaaatt ccagagagat tattccaaga caggggtcaa acactgacat tttaagtgag      720

ccagctgcct tgtctgttat cagtaacatg aacaattctc catttgactt atgtcatgtt      780

ttgttatctt tattagaaaa agtttgtaag tttgacgtta ccttgaatca taattctcct      840

ttagcagcca gtgtagtgcc cacactaact gaattcctag caggctttgg ggactgctgc      900

agtctgagcg acaacttgga gagtcgagta gtttctgcag gttggaccga agaaccggtg      960

gctttgattc aaaggatgct ctttcgaaca gtgttgcatc ttctgtcagt agatgttagt     1020

actgcagaga tgatgccaga aaatcttagg aaaaatttaa ctgaattgct tagagcagct     1080

ttaaaaatta gaatatgcct agaaaagcag cctgaccctt ttgcaccaag acaaaagaaa     1140

acactgcagg aggttcagga agattttgtg ttttcaaagt atcgtcatag agcccttctt     1200

ttacctgagc ttttggaagg agttcttcag attctgatct gttgtcttca aagtgcagct     1260

tcaaatccct tctacttcag tcaagccatg gatttggttc aagaattcat tcagcatcat     1320

ggatttaatt tatttgaaac agcagttctt caaatggaat ggctggtttt aagagatgga     1380

gttcctcccg aggcctcaga gcatttgaaa gccctaataa atagtgtgat gaaaataatg     1440

agcactgtca aaaaagtgaa atcagagcaa cttcatcatt cgatgtgtac aagaaaaagg     1500

cacagacgat gtgaatattc tcattttatg catcatcacc gagatctctc aggtcttctg     1560

gtttcggctt ttaaaaacca ggtttccaaa aacccatttg aagagactgc agatggagat     1620

gtttattatc ctgagcggtg ctgttgcatt gcagtgtgtg cccatcagtg cttgcgctta     1680

ctacagcagg cttccttgag cagcacttgt gtccagatcc tatcgggtgt tcataacatt     1740

ggaatatgct gttgtatgga tcccaaatct gtaatcattc ctttgctcca tgcttttaaa     1800

ttgccagcac tgaaaaattt tcagcagcat atattgaata tccttaacaa acttattttg     1860

gatcagttag gaggagcaga gatatcacca aaaattaaaa aagcagcttg taatatttgt     1920

actgttgact ctgaccaact agcccaatta gaagagacac tgcagggaaa cttatgtgat     1980

gctgaactct cctcaagttt atccagtcct tcttacagat ttcaagggat cctgcccagc     2040

agtggatctg aagatttgtt gtggaaatgg gatgctttaa aggcttatca gaactttgtt     2100

tttgaagaag acagattaca tagtatacag attgcaaatc acatttgcaa tttaatccag     2160

aaaggcaata tagttgttca gtggaaatta tataattaca tatttaatcc tgtgctccaa     2220

agaggagttg aattagcaca tcattgtcaa cacctaagcg ttacttcagc tcaaagtcat     2280

gtatgtagcc atcataacca gtgcttgcct caggacgtgc ttcagattta tgtaaaaact     2340

ctgcctatcc tgcttaaatc cagggtaata agagatttgt ttttgagttg taatggagta     2400

agtcaaataa tcgaattaaa ttgcttaaat ggtattcgaa gtcattctct aaaagcattt     2460

gaaactctga taatcagcct aggggagcaa cagaaagatg cctcagttcc agatattgat     2520

gggatagaca ttgaacagaa ggagttgtcc tctgtacatg tgggtacttc ttttcatcat     2580

cagcaagctt attcagattc tcctcagagt ctcagcaaat tttatgctgg cctcaaagaa     2640

gcttatccaa agagacggaa gactgttaac caagatgttc atatcaacac aataaaccta     2700

ttcctctgtg tggctttttt atgcgtaagt aaagaagcag agtctgacag ggagtcggcc     2760

aatgactcag aagatacttc tggctatgac agcacagcca gcgagccttt aagtcatatg     2820

ctgccatgta tatctctcga gagccttgtc ttgccttctc ctgaacatat gcaccaagca     2880

gcagacattt ggtctatgtg tcgttggatc tacatgttga gttcagtgtt ccagaaacag     2940

ttttataggc ttggtggttt ccgagtatgc cataagttaa tatttatgat aatacagaaa     3000

ctgttcagaa gtcacaaaga ggagcaagga aaaaaggagg gagatacaag tgtaaatgaa     3060

aaccaggatt taaacagaat ttctcaacct aagagaacta tgaaggaaga tttattatct     3120

ttggctataa aaagtgaccc cataccatca gaactaggta gtctaaaaaa gagtgctgac     3180

agtttaggta aattagagtt acagcatatt tcttccataa atgtggaaga agtttcagct     3240

actgaagccg ctcccgagga agcaaagcta tttacaagtc aagaaagtga gacctcactt     3300

caaagtatac gacttttgga agcccttctg gccatttgtc ttcatggtgc cagaactagt     3360

caacagaaga tggaattgga gttacctaat cagaacttgt ctgtggaaag tatattattt     3420

gaaatgaggg accatctttc ccagtcaaag gtgattgaaa cacaactagc aaagccttta     3480

tttgatgccc tgcttcgagt tgccctcggg aattattcag cagattttga acataatgat     3540

gctatgactg agaagagtca tcaatctgca gaagaattgt catcccagcc tggtgatttt     3600

tcagaagaag ctgaggattc tcagtgttgt agttttaaac ttttagttga agaagaaggt     3660

tacgaagcag atagtgaaag caatcctgaa gatggcgaaa cccaggatga tggggtagac     3720

ttaaagtctg aaacagaagg tttcagtgca tcaagcagtc caaatgactt actcgaaaac     3780

ctcactcaag gggaaataat ttatcctgag atttgtatgc tggaattaaa tttgctttct     3840

gctagtaaag ccaaacttga tgtgcttgcc catgtatttg agagtttttt gaaaattatt     3900

aggcagaaag aaaagaatgt ttttctgctc atgcaacagg gaactgtgaa aaatctttta     3960

ggagggttct tgagtatttt aacacaggat gattctgatt ttcaagcatg ccagagagta     4020

ttggtggatc ttttggtatc tttgatgagt tcaagaacat gttcagaaga gctaaccctt     4080

cttttgagaa tatttctgga gaaatctcct tgtacaaaaa ttcttcttct gggtattctg     4140

aaaattattg aaagtgatac tactatgagc ccttcacagt atctaacctt ccctttactg     4200

cacgctccaa atttaagcaa cggtgtttca tcacaaaagt atcctgggat tttaaacagt     4260

aaggccatgg gtttattgag aagagcacga gtttcacgga gcaagaaaga ggctgataga     4320

gagagttttc cccatcggct gctttcatct tggcacatag ccccagtcca cctgccgttg     4380

ctggggcaaa actgctggcc acacctatca gaaggtttca gtgtttccct gtggtttaat     4440

gtggagtgta tccatgaagc tgagagtact acagaaaaag gaaagaagat aaagaaaaga     4500

aacaaatcat taattttacc agatagcagt tttgatggta cagagagcga cagaccagaa     4560

ggtgcagagt acataaatcc tggtgaaaga ctcatagaag aaggatgtat tcatataatt     4620

tcactgggat ccaaagcgtt gatgatccaa gtgtgggctg atccccacaa tgccactctt     4680

atctttcgtg tgtgcatgga ttcaaatgat gacatgaaag ctgttttact agcacaggtt     4740

gaatcacagg agaatatttt cctcccaagc aaatggcaac atttagtact cacctactta     4800

cagcagcccc aagggaaaag gaggattcat gggaaaatct ccatatgggt ctctggacag     4860

aggaagcctg atgttacttt ggattttatg cttccaagaa aaacaagttt gtcatctgat     4920

agcaataaaa cattttgcat gattggccat tgtttatcat cccaagaaga gtttttgcag     4980

ttggctggaa aatgggacct gggaaatttg cttctcttca acggagctaa ggttggttca     5040

caagaggcct tttatctgta tgcttgtgga cccaaccata catctgtaat gccatgtaag     5100

tatggcaagc cagtcaatga ctactccaaa tatattaata aagaaatttt gcgatgtgaa     5160

caaatcagag aactttttat gaccaagaaa gatgtggata ttggtctctt aattgaaagt     5220

ctttcagttg tttatacaac ttactgtcct gctcagtata ccatctatga accagtgatt     5280

agacttaaag gtcaaatgaa aacccaactc tctcaaagac ccttcagctc aaaagaagtt     5340

cagagcatct tattagaacc tcatcatcta aagaatctcc aacctactga atataaaact     5400

attcaaggca ttctgcacga aattggtgga actggcatat ttgtttttct ctttgccagg     5460

gttgttgaac tcagtagctg tgaagaaact caagcattag cactgcgagt tatactctca     5520

ttaattaaat acaaccaaca aagagtacat gaattagaaa attgtaatgg actttctatg     5580

attcatcagg tgttgatcaa acaaaaatgc attgttgggt tttacatttt gaagaccctt     5640

cttgaaggat gctgtggtga agatattatt tatatgaatg agaatggaga gtttaagttg     5700

gatgtagact ctaatgctat aatccaagat gttaagctgt tagaggaact attgcttgac     5760

tggaagatat ggagtaaagc agagcaaggt gtttgggaaa ctttgctagc agctctagaa     5820

gtcctcatca gagcagatca ccaccagcag atgtttaata ttaagcagtt attgaaagct     5880

caagtggttc atcactttct actgacttgt caggttttgc aggaatacaa agaggggcaa     5940

ctcacaccca tgccccgaga ggtttgtaga tcatttgtga aaattatagc agaagtcctt     6000

ggatctcctc cagatttgga attattgaca attatcttca atttcctttt agcagttcac     6060

cctcctacta atacttacgt ttgtcacaat cccacgaact tctacttttc tttgcacata     6120

gatggcaaga tctttcagga gaaagtgcgg tcaatcatgt acctgaggca ttccagcagt     6180

ggaggaaggt cccttatgag ccctggattt atggtaataa gcccatctgg ttttactgct     6240

tcaccatatg aaggagagaa ttcctctaat attattccac aacagatggc cgcccatatg     6300

ctgcgttcta gaagcctacc agcattccct acttcttcac tactaacgca atcacaaaaa     6360

ctgactggaa gtttgggttg tagtatcgac aggttacaaa atattgcaga tacttatgtt     6420

gccacccaat caaagaaaca aaattctttg gggagttccg acacactgaa aaaaggcaaa     6480

gaggacgcat tcatcagtag ctgtgagtct gcaaaaactg tttgtgaaat ggaagctgtc     6540

ctctcagccc aggtctctgt cagtgatgtc ccaaagggag tgctgggatt tccagtggtc     6600

aaagcagatc ataaacagtt gggagcagaa cccaggtcag aagatgacag tcctggggat     6660

gagtcctgcc cacgccgacc tgattaccta aagggattgg cctccttcca gcgaagccac     6720

agcactattg caagccttgg gctagctttt ccttcacaga acggatctgc agctgttggc     6780

cgttggccaa gtcttgttga tagaaacact gatgattggg aaaactttgc ctattctctt     6840

ggttatgagc caaattacaa ccgaactgca agtgctcaca gtgtaactga agactgtttg     6900

gtacctatat gctgtggatt atatgaactc ctaagtgggg ttcttcttat cctgcctgat     6960

gttttgcttg aagatgtgat ggacaagctt attcaagcag atacactttt ggtcctcgtt     7020

aaccacccat caccagctat acaacaaggt gttattaaac tattagatgc atattttgct     7080

agagcatcta aggaacaaaa agataaattt ctgaagaatc gtggattttc cttgctagcc     7140

aaccagttgt atcttcatcg aggaactcaa gaattgttag aatgcttcat cgaaatgttc     7200

tttggtcgac atattggcct tgatgaagaa tttgatctgg aagatgtgag aaacatggga     7260

ttgtttcaga agtggtctgt cattcctatt ctgggactaa tagagacctc tctatatgac     7320

aacatactct tgcataatgc tcttttactt cttctccaaa ttttaaattc ttgttctaag     7380

gtagcagata tgttgctgga taatggtcta ctctatgtgt tatgtaatac agtagcagcc     7440

ctgaatggat tagaaaagaa cattcccatg agtgaatata aattgcttgc ttgtgatata     7500

cagcaacttt tcatagcagt tacaattcat gcttgcagtt cctcaggctc acaatatttt     7560

agggttattg aagaccttat tgtaatgctt ggatatcttc aaaatagcaa aaacaagagg     7620

acacaaaata tggctgttgc actacagctt agagttctcc aggctgctat ggaatttata     7680

aggaccaccg caaatcatga ctctgaaaac ctcacagatt cactccagtc accttctgct     7740

ccccatcatg cagtagttca aaagcggaaa agcattgctg gtcctcgaaa atttcccctt     7800

gctcaaactg aatcgcttct gatgaaaatg cgttcagtgg caaatgatga gcttcatgtg     7860

atgatgcaac ggagaatgag ccaagagaac cctagccaag caactgaaac ggaacttgcg     7920

cagagactac agaggctcac tgttttagca gtcaacagga ttatttatca agaatttaat     7980

tcagacatta ttgacatttt gagaactcca gaaaatgtaa ctcaaagcaa gacctcagtt     8040

ttccagaccg aaatttctga ggaaaatatt catcatgaac agtcttctgt tttcaatcca     8100

tttcagaaag aaatttttac atatctggta gaaggattca aagtatctat tggttcaagt     8160

aaagccagtg gttccaagca gcaatggact aaaattctgt ggtcttgtaa ggagaccttc     8220

cgaatgcagc ttgggagact actagtgcat attttgtcgc cagcccacgc tgcacaagag     8280

agaaagcaaa tttttgaaat agttcatgaa ccaaatcatc aggaaatact acgagactgt     8340

ctcagcccat ccctacaaca tggagccaag ttagttttgt atttgtcaga gttgatacat     8400

aatcaccaag gtgaattgac tgaagaagag ctaggcacag cagaactgct tatgaatgct     8460

ttgaagttat gtggtcacaa gtgcatccct cccagtgcat caacaaaagc agaccttatt     8520

aaaatgatca aagaggaaca aaagaaatat gaaactgaag aaggagtgaa taaagctgct     8580

tggcagaaaa cagttaacaa taatcaacaa agtctctttc agcgtctgga ttcaaaatca     8640

aaggatatat ctaaaatagc tgcagatatc acccaggcag tgtctctctc ccaaggaaat     8700

gagagaaaaa aggtgatcca gcatattaga ggaatgtata aagtagattt gagtgccagc     8760

agacattggc aggaacttat tcagcagctg acacatgata gagcagtatg gtatgacccc     8820

atctactatc caacctcatg gcagttggat ccaacagaag ggccaaatcg agagaggaga     8880

cgtttacaga gatgttattt aactattcca aataagtatc tccttaggga tagacagaaa     8940

tcagaagatg ttgtcaaacc accactctct tacctgtttg aagacaaaac tcattcttct     9000

ttctcttcta ctgtcaaaga caaagctgca agtgaatcta taagagtgaa tcgaagatgc     9060

atcagtgttg caccatctag agagacagct ggtgaattgt tactaggtaa atgtggaatg     9120

tattttgtgg aagataatgc ttctgataca gttgaaagtt cgagccttca gggagagttg     9180

gaaccagcat cattttcctg gacatatgaa gaaattaaag aagttcacaa gcgttggtgg     9240

caattgagag ataatgctgt agaaatcttt ctaacaaatg gcagaacact cctgttggca     9300

tttgataaca ccaaggttcg tgatgatgta taccacaata tactcacaaa taacctccct     9360

aatcttctgg aatatggtaa catcaccgct ctgacaaatt tatggtatac tgggcaaatt     9420

actaattttg aatatttgac tcacttaaac aaacatgctg gccgatcctt caatgatctc     9480

atgcagtatc ctgtgttccc atttatactt gctgactacg ttagtgagac acttgacctc     9540

aatgatctgt tgatatacag aaatctctct aaacctatag ctgttcagta taaagaaaaa     9600

gaagatcgtt atgtggacac atacaagtac ttggaggaag agtaccgcaa aggagccaga     9660

gaagatgacc ccatgcctcc cgtgcagccc tatcactatg gctcccacta ttccaatagc     9720

ggcactgtgc ttcacttcct ggtcaggatg cctcctttca ctaaaatgtt tttagcctat     9780

caagatcaaa gttttgacat tccagacaga acttttcatt ctacaaatac aacttggcga     9840

ctctcatctt ttgaatctat gactgatgtg aaagaactta tcccagagtt tttctatctt     9900

ccagagttcc tagttaaccg tgaaggtttt gattttggtg tgcgtcagaa tggtgaacgg     9960

gttaatcacg tcaaccttcc cccttgggcg cgtaatgatc ctcgtctttt tatcctcatc    10020

catcggcagg ctctagagtc tgactacgtg tcgcagaaca tctgtcagtg gattgacttg    10080

gtgtttgggt ataagcaaaa ggggaaggct tctgttcaag cgatcaatgt ttttcatcct    10140

gctacatatt ttggaatgga tgtctctgca gttgaagatc cagttcagag acgagcgcta    10200

gaaaccatga taaaaaccta cgggcagact ccccgtcagc tgttccacat ggcccatgtg    10260

agcagacctg gagccaagct caatattgaa ggagagcttc cagctgctgt ggggttgcta    10320

gtgcagtttg ctttcaggga gacccgagaa caggtcaaag aaatcaccta tccgagtcct    10380

ttgtcatgga taaaaggctt gaaatggggg gaatacgtgg gttcccccag tgctccagta    10440

cctgtggtct gcttcagcca gccccacgga gaaagatttg gctctctcca ggctctgccc    10500

accagagcaa tctgtggttt gtcacggaat ttctgtcttc tgatgacata tagcaaggaa    10560

caaggtgtga gaagcatgaa cagtacggac attcagtggt cagccatcct gagctgggga    10620

tatgctgata atattttaag gttgaagagt aaacaaagtg agcctccagt aaactttatt    10680

caaagttcac aacagtacca ggtgactagt tgtgcttggg tgcctgacag ttgccagctg    10740

tttactggaa gcaaatgcgg tgtcatcaca gcctacacaa acagatttac aagcagcacg    10800

ccatcagaaa tagaaatgga gactcaaata catctctatg gtcacacaga agagataacc    10860

agcttatttg tttgcaaacc atacagtata ctgataagtg tgagcagaga cggaacctgc    10920

atcatatggg atttaaacag gttatgctat gtacaaagtc tggcgggaca caaaagccct    10980

gtcacagctg tctctgccag tgaaacctca ggtgatattg ctactgtgtg tgattcagct    11040

ggcggaggca gtgacctcag actctggacg gtgaacgggg atctcgttgg acatgtccac    11100

tgcagggaga tcatctgttc cgtggctttc tccaaccagc ctgagggagt atctatcaat    11160

gtaatcgctg ggggattaga aaatggaatt gtaaggttat ggagcacatg ggacttaaag    11220

cctgtgagag aaattacatt tcccaaatca aataagccca tcatcagcct tacattttct    11280

tgtgatggcc accatttgta cacagcaaac agtgatggga ccgtgattgc ctggtgtcgg    11340

aaggaccagc agcgcttgaa acagccaatg ttctattcct tccttagcag ctatgcagcc    11400

gggtga                                                               11406


<210>  362
<211>  3051
<212>  DNA
<213>  Homo sapiens;

<400>  362
atggtgctgc ccacctgccc catggcggag ttcgcgctgc cgcggcacag cgcggtcatg       60

gagcgccttc gccggcgcat cgagctgtgc cggcgccacc acagcacctg cgaggcccgc      120

tacgaggccg tgtcgcccga gcgcctggag ctggagcgcc aacacacctt cgccctgcac      180

cagcgctgca tccaggccaa ggccaagcgc gccgggaagc acaggcagcc gcccgccgcc      240

acggccccgg cgcccgccgc cccggccccg cgcctggacg ccgctgacgg ccccgagcac      300

ggccgcccgg ccacgcatct tcatgataca gttaagagga atcttgacag cgccacttcc      360

cctcagaatg gcgatcaaca gaatggctac ggggacctct ttcctgggca taagaagact      420

cgccgggagg cccctctggg agttgccatc tcttccaatg gactgcctcc agcctccccc      480

ctcggtcagt ctgacaagcc ttctggagcc gacgccctgc agtccagtgg gaagcactct      540

ctggggctag actctctcaa caaaaagcgt ctggctgact ccagccttca cttgaatgga      600

ggcagtaacc ccagtgagtc atttcctctg agcctgaata aagaactgaa gcaggagcct      660

gtcgaagacc tgccttgcat gatcactggg actgtcggct ccatatcgca aagcaacctc      720

atgccagacc tcaaccttaa cgagcaggag tggaaggagc tcatcgagga gctgaacagg      780

tcggtgcccg atgaagacat gaaggacctg tttaatgagg acttcgagga gaagaaggac      840

ccagagtctt ctggctctgc cacacaaacc cccttggcac aggacattaa tattaagacg      900

gaattctctc cagcagcctt tgagcaagaa cagttaggct ctccacaagt gagggccggg      960

tctgcagggc agacctttct ggggccttcc tctgcccctg tgagtacaga ttcccccagc     1020

ctagggggct cccaaacctt attccacacc tctggtcagc cccgggcgga caatcccagt     1080

ccaaacctga tgccggcatc agcccaggcc cagaacgcac aaagagccct tgcaggtgtg     1140

gtattgccca gtcagggccc aggaggggcc tcagagctgt cctctgccca ccagctccag     1200

cagatcgctg ccaagcagaa gcgcgagcag atgctccaga acccacagca ggccaccccg     1260

gcaccagccc cgggccagat gtccacatgg cagcagacgg ggccctccca cagttcctta     1320

gatgtccctt accccatgga gaagcctgcc agcccttcca gctacaagca agacttcact     1380

aactccaaac tgctcatgat gcctagtgtg aataagagtt cccctcggcc cggaggcccc     1440

tacctccagc ccagccatgt gaacctgctg agtcaccagc caccgagtaa cttgaatcag     1500

aactccgcga ataaccaggg gtctgtgctg gactacggca atacaaaacc cctttctcat     1560

tacaaagcgg actgtgggca aggcagcccg gggtctggcc agagcaagcc agccctgatg     1620

gcttatcttc cccagcagct gtcccatata agtcacgagc agaactccct gtttctgatg     1680

aagccaaagc caggaaatat gcctttccga tcactggttc cacctggcca ggagcagaac     1740

ccttccagtg tccctgtgca agcccaggct accagtgttg ggacccagcc gcctgccgtg     1800

tccgtggcca gctcccacaa cagctccccc tatctcagca gccagcaaca ggccgctgta     1860

atgaagcagc atcagttgct tttggaccaa cagaaacaaa gggagcagca gcaaaagcat     1920

ttacagcaac agcagttcct tcagaggcaa cagcaccttc tcgcggaaca ggagaagcaa     1980

cagtttcagc gccatctgac ccgcccacca ccccagtacc aagacccgac acaaggcagc     2040

ttcccacagc aggttggaca gttcacaggg tcctctgctg ccgtgcccgg catgaacacc     2100

ttgggtccat ccaactccag ctgtcctcga gtgttccctc aggctgggaa tctgatgcca     2160

atgggccctg gacatgcttc agtttcctct ctccccacaa actcaggcca acaggaccgg     2220

ggtgtggctc agttccctgg ctcccaaaac atgcctcaga gcagcctcta tggcatggct     2280

tctggcataa cccagatagt tgcccagccc ccgccacagg ccaccaatgg acatgcccac     2340

attccacggc agaccaacgt gggccagaac acctccgtct cagctgccta tgggcagaac     2400

tctctgggaa gctctggcct ctcccagcag cacaataagg ggaccctgaa ccctggttta     2460

acaaagccac cggtcccaag ggtgtcacca gccatgggag gccagaattc ctcctggcag     2520

catcagggaa tgccgaacct cagtggccag accccaggga acagcaacgt gagtcccttc     2580

actgcagcct ccagtttcca catgcagcag caggcccacc tgaaaatgtc tagcccgcaa     2640

ttctcccagg cagtgcccaa caggcccatg gctcccatga gctcagcagc tgccgtgggg     2700

tccttgctac ccccagtgag tgcacagcag aggaccagcg cccctgcccc agcaccaccc     2760

ccaacagccc ctcagcaggg cttgcctggc ctgagcccag cagggcctga gctgggggcc     2820

ttcagccaga gccctgcctc acagatgggc ggtcgggcgg ggctgcactg cacccaggcc     2880

taccctgtgc ggaccgcggg ccaggagctg ccttttgcct atagcgggca gccaggtggc     2940

agtgggctct ctagtgtggc tggacacacc gatctgatcg actccctgct gaagaacagg     3000

acttcagagg agtggatgag tgatttggac gacctgttag ggtctcagta a              3051


<210>  363
<211>  1296
<212>  DNA
<213>  Homo sapiens;

<400>  363
atgttcttcg ggggagaagg gagcttgact tacactttgg taataatttg cttcctgaca       60

ctaaggctgt ctgctagtca gaattgcctc aaaaagagtc tagaagatgt tgtcattgac      120

atccagtcat ctctttctaa gggaatcaga ggcaatgagc ccgtatatac ttcaactcaa      180

gaagactgca ttaattcttg ctgttcaaca aaaaacatat caggggacaa agcatgtaac      240

ttgatgatct tcgacactcg aaaaacagct agacaaccca actgctacct atttttctgt      300

cccaacgagg aagcctgtcc attgaaacca gcaaaaggac ttatgagtta caggataatt      360

acagattttc catctttgac cagaaatttg ccaagccaag agttacccca ggaagattct      420

ctcttacatg gccaattttc acaagcagtc actcccctag cccatcatca cacagattat      480

tcaaagccca ccgatatctc atggagagac acactttctc agaagtttgg atcctcagat      540

cacttggaga aactatttaa gatggatgaa gcaagtgccc agctccttgc ttataaggaa      600

aaaggccatt ctcagagttc acaattttcc tctgatcaag aaatagctca tctgctgcct      660

gaaaatgtga gtgcgctccc agctacggtg gcagttgctt ctccacatac cacctcggct      720

actccaaagc ccgccaccct tctacccacc aatgcttcag tgacaccttc tgggacttcc      780

cagccacagc tggccaccac agctccacct gtaaccactg tcacttctca gcctcccacg      840

accctcattt ctacagtttt tacacgggct gcggctacac tccaagcaat ggctacaaca      900

gcagttctga ctaccacctt tcaggcacct acggactcga aaggcagctt agaaaccata      960

ccgtttacag aaatctccaa cctaactttg aacacaggga atgtgtataa ccctactgca     1020

ctttctatgt caaatgtgga gtcttccact atgaataaaa ctgcttcctg ggaaggtagg     1080

gaggccagtc caggcagttc ctcccagggc agtgttccag aaaatcagta cggccttcca     1140

tttgaaaaat ggcttcttat cgggtccctg ctctttggtg tcctgttcct ggtgataggc     1200

ctcgtcctcc tgggtagaat cctctcggaa tcactccgca ggaaacgtta ctcaagactg     1260

gattatttga tcaatgggat ctatgtggac atctaa                               1296


<210>  364
<211>  378
<212>  DNA
<213>  Homo sapiens;

<400>  364
atgccgtcgg agaagacctt caagcagcgc cgcaccttcg aacaaagagt agaagatgtc       60

cgacttattc gagagcagca tccaaccaaa atcccggtga taatagaacg atacaagggt      120

gagaagcagc ttcctgttct ggataaaaca aagttccttg tacctgacca tgtcaacatg      180

agtgagctca tcaagataat tagaaggcgc ttacagctca atgctaatca ggccttcttc      240

ctgttggtga acggacacag catggtcagc gtctccacac caatctcaga ggtgtatgag      300

agtgagaaag atgaagatgg attcctgtac atggtctatg cctcccagga gacgttcggg      360

atgaaattgt cagtgtaa                                                    378


<210>  365
<211>  2544
<212>  DNA
<213>  Homo sapiens;

<400>  365
atggagccct tgaagagcct cttcctcaag agccctctag ggtcatggaa tggcagtggc       60

agcgggggtg gtgggggcgg tggaggaggc cggcctgagg ggtctccaaa ggcagcgggt      120

tatgccaacc cggtgtggac agccctgttc gactacgagc ccagtgggca ggatgagctg      180

gccctgagga agggtgaccg tgtggaggtg ctgtcccggg acgcagccat ctcaggagac      240

gagggctggt gggcgggcca ggtgggtggc caggtgggca tcttcccgtc caactatgtg      300

tctcggggtg gcggcccgcc cccctgcgag gtggccagct tccaggagct gcggctggag      360

gaggtgatcg gcattggagg ctttggcaag gtgtacaggg gcagctggcg aggtgagctg      420

gtggctgtga aggcagctcg ccaggacccc gatgaggaca tcagtgtgac agccgagagc      480

gttcgccagg aggcccggct cttcgccatg ctggcacacc ccaacatcat tgccctcaag      540

gctgtgtgcc tggaggagcc caacctgtgc ctggtgatgg agtatgcagc cggtgggccc      600

ctcagccgag ctctggccgg gcggcgcgtg cctccccatg tgctggtcaa ctgggctgtg      660

cagattgccc gtgggatgca ctacctgcac tgcgaggccc tggtgcccgt catccaccgt      720

gatctcaagt ccaacaacat tttgctgctg cagcccattg agagtgacga catggagcac      780

aagaccctga agatcaccga ctttggcctg gcccgagagt ggcacaaaac cacacaaatg      840

agtgccgcgg gcacctacgc ctggatggct cctgaggtta tcaaggcctc caccttctct      900

aagggcagtg acgtctggag ttttggggtg ctgctgtggg aactgctgac cggggaggtg      960

ccataccgtg gcattgactg ccttgctgtg gcctatggcg tagctgttaa caagctcaca     1020

ctgcccatcc catccacctg ccccgagccc ttcgcacagc ttatggccga ctgctgggcg     1080

caggaccccc accgcaggcc cgacttcgcc tccatcctgc agcagttgga ggcgctggag     1140

gcacaggtcc tacgggaaat gccgcgggac tccttccatt ccatgcagga aggctggaag     1200

cgcgagatcc agggtctctt cgacgagctg cgagccaagg aaaaggaact actgagccgc     1260

gaggaggagc tgacgcgagc ggcgcgcgag cagcggtcac aggcggagca gctgcggcgg     1320

cgcgagcacc tgctggccca gtgggagcta gaggtgttcg agcgcgagct gacgctgctg     1380

ctgcagcagg tggaccgcga gcgaccgcac gtgcgccgcc gccgcgggac attcaagcgc     1440

agcaagctcc gggcgcgcga cggcggcgag cgtatcagca tgccactcga cttcaagcac     1500

cgcatcaccg tgcaggcctc acccggcctt gaccggagga gaaacgtctt cgaggtcggg     1560

cctggggatt cgcccacctt tccccggttc cgagccatcc agttggagcc tgcagagcca     1620

ggccaggcat ggggccgcca gtccccccga cgtctggagg actcaagcaa tggagagcgg     1680

cgagcatgct gggcttgggg tcccagttcc cccaagcctg gggaagccca gaatgggagg     1740

agaaggtccc gcatggacga agccacatgg tacctggatt cagatgactc atccccctta     1800

ggatctcctt ccacaccccc agcactcaat ggtaaccccc cgcggcctag cctggagccc     1860

gaggagccca agaggcctgt ccccgcagag cgcggtagca gctctgggac gcccaagctg     1920

atccagcggg cgctgctgcg cggcaccgcc ctgctcgcct cgctgggcct tggccgcgac     1980

ctgcagccgc cgggaggccc aggacgcgag cgcggggagt ccccgacaac accccccacg     2040

ccaacgcccg cgccctgccc gaccgagccg cccccttccc cgctcatctg cttctcgctc     2100

aagacgcccg actccccgcc cactcctgca cccctgttgc tggacctggg tatccctgtg     2160

ggccagcggt cagccaagag cccccgacgt gaggaggagc cccgcggagg cactgtctca     2220

cccccaccgg ggacatcacg ctctgctcct ggcaccccag gcaccccacg ttcaccaccc     2280

ctgggcctca tcagccgacc tcggccctcg ccccttcgca gccgcattga tccctggagc     2340

tttgtgtcag ctgggccacg gccttctccc ctgccatcac cacagcctgc accccgccga     2400

gcaccctgga ccttgttccc ggactcagac cccttctggg actccccacc tgccaacccc     2460

ttccaggggg gcccccagga ctgcagggca cagaccaaag acatgggtgc ccaggccccg     2520

tgggtgccgg aagcggggcc ttga                                            2544


<210>  366
<211>  1881
<212>  DNA
<213>  Homo sapiens;

<400>  366
atggacgaac aggaggcatt gaactcaatc atgaacgatc tggtggccct ccagatgaac       60

cgacgtcacc ggatgcctgg atatgagacc atgaagaaca aagacacagg tcactcaaat      120

aggcagagtg acgtcagaat caagttcgag cacaacgggg agaggcgaat tatagcgttc      180

agccggcctg tgaaatatga agatgtggag cacaaggtga caacagtatt tggacaacct      240

cttgatctac attacatgaa caatgagctc tccatcctgc tgaaaaacca agatgatctt      300

gataaagcaa ttgacatttt agatagaagc tcaagcatga aaagccttag gatattgctg      360

ttgtcccagg acagaaacca taacagttcc tctccccact ctggggtgtc cagacaggtg      420

cggatcaagg cttcccagtc cgcaggggat ataaatacta tctaccagcc ccccgagccc      480

agaagcaggc acctctctgt cagctcccag aaccctggcc gaagctcacc tccccctggc      540

tatgttcctg agcggcagca gcacattgcc cggcaggggt cctacaccag catcaacagt      600

gagggggagt tcatcccaga gaccagcgag cagtgcatgc tggatcccct gagcagtgca      660

gaaaattcct tgtctggaag ctgccaatcc ttggacaggt cagcagacag cccatccttc      720

cggaaatcac gaatgtcccg tgcccagagc ttccctgaca acagacagga atactcagat      780

cgggaaactc agctttatga caaaggggtc aaaggtggaa cctacccccg gcgctaccac      840

gtgtctgtgc accacaagga ctacagtgat ggcagaagaa catttccccg aatacggcgt      900

catcaaggca acttgttcac cctggtgccc tccagccgct ccctgagcac aaatggcgag      960

aacatgggtc tggctgtgca atacctggac ccccgtgggc gcctgcggag tgcggacagc     1020

gagaatgccc tctctgtgca ggagaggaat gtgccaacca agtctcccag tgcccccatc     1080

aactggcgcc ggggaaagct cctgggccag ggtgccttcg gcagggtcta tttgtgctat     1140

gacgtggaca cgggacgtga acttgcttcc aagcaggtcc aatttgatcc agacagtcct     1200

gagacaagca aggaggtgag tgctctggag tgcgagatcc agttgctaaa gaacttgcag     1260

catgagcgca tcgtgcagta ctatggctgt ctgcgggacc gcgctgagaa gaccctgacc     1320

atcttcatgg agtacatgcc agggggctcg gtgaaagacc agttgaaggc ttacggtgct     1380

ctgacagaga gcgtgacccg aaagtacacg cggcagatcc tggagggcat gtcctacctg     1440

cacagcaaca tgattgttca ccgggacatt aagggagcca acatcctccg agactctgct     1500

gggaatgtaa agctggggga ctttggggcc agcaaacgcc tgcagacgat ctgtatgtcg     1560

gggacgggca tgcgctccgt cactggcaca ccctactgga tgagccctga ggtgatcagc     1620

ggcgagggct atggaaggaa agcagacgtg tggagcctgg gctgcactgt ggtggagatg     1680

ctgacagaga aaccaccgtg ggcagagtat gaagctatgg ccgccatctt caagattgcc     1740

acccagccca ccaatcctca gctgccctcc cacatctctg aacatggccg ggacttcctg     1800

aggcgcattt ttgtggaggc tcgccagaga ccttcagctg aggagctgct cacacaccac     1860

tttgcacagc tcatgtactg a                                               1881


<210>  367
<211>  4125
<212>  DNA
<213>  Homo sapiens;

<400>  367
atgagcacgg aggcggacga gggcatcact ttctctgtgc cacccttcgc cccctcgggc       60

ttctgcacca tccccgaggg cggcatctgc aggaggggag gagcggcggc ggtgggcgag      120

ggcgaggagc accagctgcc accgccgccg ccgggcagct tctggaacgt ggagagcgcc      180

gctgcccctg gcatcggttg tccggcggcc acctcctcga gcagtgccac ccgaggccgg      240

ggcagctctg ttggcggggg cagccgacgg accacggtgg catatgtgat caacgaagcg      300

agccaagggc aactggtggt ggccgagagc gaggccctgc agagcttgcg ggaggcgtgc      360

gagacagtgg gcgccaccct ggaaaccctg cattttggga aactcgactt tggagaaacc      420

accgtgctgg accgctttta caatgcagat attgcggtgg tggagatgag cgatgccttc      480

cggcagccgt ccttgtttta ccaccttggg gtgagagaaa gtttcagcat ggccaacaac      540

atcatcctct actgtgatac taactcggac tctctgcagt cactgaagga aataatttgc      600

cagaagaata ctatgtgcac tgggaactac acctttgttc cttacatgat aactccacat      660

aacaaagtct actgctgtga cagcagcttc atgaaggggt tgacagagct catgcaaccg      720

aacttcgagc tgcttcttgg acccatctgc ttacctcttg tggatcgttt tattcaactt      780

ttgaaggtgg cacaagcaag ttctagccag tacttccggg aatctatact caatgacatc      840

aggaaagctc gtaatttata cactggtaaa gaattggcag ctgagttggc aagaattcgg      900

cagcgagtag ataatatcga agtcttgaca gcagatattg tcataaatct gttactttcc      960

tacagagata tccaggacta tgattctatt gtgaagctgg tagagacttt agaaaaactg     1020

ccaacctttg atttggcctc ccatcaccat gtgaagtttc attatgcatt tgcactgaat     1080

aggagaaatc tccctggtga cagagcaaaa gctcttgata ttatgattcc catggtgcaa     1140

agcgaaggac aagttgcttc agatatgtat tgcctagttg gtcgaatcta caaagatatg     1200

tttttggact ctaatttcac ggacactgaa agcagagacc atggagcttc ttggttcaaa     1260

aaggcatttg aatctgagcc aacactacag tcaggaatta attatgcggt cctcctcctg     1320

gcagctggac accagtttga atcttccttt gagctccgga aagttggggt gaagctaagt     1380

agtcttcttg gtaaaaaggg aaacttggaa aaactccaga gctactggga agttggattt     1440

tttctggggg ccagcgtcct agccaatgac cacatgagag tcattcaagc atctgaaaag     1500

ctttttaaac tgaagacacc agcatggtac ctcaagtcta ttgtagagac aattttaata     1560

tataagcatt ttgtgaaact gaccacagaa cagcctgtgg ccaagcaaga acttgtggac     1620

ttttggatgg atttcctggt cgaggccaca aagacagatg ttactgtggt taggtttcca     1680

gtattaatat tagaaccaac caaaatctat caaccttctt atttgtctat caacaatgaa     1740

gttgaggaaa agacaatctc tatttggcac gtgcttcctg atgacaagaa aggtatacat     1800

gagtggaatt ttagtgcctc ttctgtcagg ggagtgagta tttctaaatt tgaagaaaga     1860

tgctgctttc tttatgtgct tcacaattct gatgatttcc aaatctattt ctgtacagaa     1920

cttcattgta aaaagttttt tgagatggtg aacaccatta ccgaagagaa ggggagaagc     1980

acagaggaag gagactgtga aagtgacttg ctggagtatg actatgaata tgatgaaaat     2040

ggtgacagag tcgttttagg aaaaggcact tatgggatag tctacgcagg tcgggacttg     2100

agcaaccaag tcagaattgc tattaaggaa atcccagaga gagacagcag atactctcag     2160

cccctgcatg aagaaatagc attgcataaa cacctgaagc acaaaaatat tgtccagtat     2220

ctgggctctt tcagtgagaa tggtttcatt aaaatcttca tggagcaggt ccctggagga     2280

agtctttctg ctctccttcg ttccaaatgg ggtccattaa aagacaatga gcaaacaatt     2340

ggcttttata caaagcaaat actggaagga ttaaaatatc tccatgacaa tcagatagtt     2400

caccgggaca taaagggtga caatgtgttg attaatacct acagtggtgt tctcaagatc     2460

tctgacttcg gaacatcaaa gaggcttgct ggcataaacc cctgtactga aacttttact     2520

ggtaccctcc agtatatggc accagaaata atagataaag gaccaagagg ctacggaaaa     2580

gcagcagaca tctggtctct gggctgtaca atcattgaaa tggccacagg aaaaccccca     2640

ttttatgaac tgggagaacc acaagcagct atgttcaagg tgggaatgtt taaagtccac     2700

cctgagatcc cagagtccat gtctgcagag gccaaggcat tcatactgaa atgttttgaa     2760

ccagatcctg acaagagagc ctgtgctaac gacttgcttg ttgatgagtt tttaaaagtt     2820

tcaagcaaaa agaaaaagac acaacctaag ctttcagctc tttcagctgg atcaaatgaa     2880

tatctcagga gtatatcctt gccggtacct gtgctggtgg aggacaccag cagcagcagt     2940

gagtacggct cagtttcacc cgacacggag ttgaaagtgg accccttctc tttcaaaaca     3000

agagccaagt cctgcggaga aagagatgtc aagggaattc ggacactctt tttgggcatt     3060

ccagatgaga attttgaaga tcacagtgct cctccttccc ctgaagaaaa agattctgga     3120

ttcttcatgc tgaggaagga cagtgagagg cgagctaccc ttcacaggat cctgacggaa     3180

gaccaagaca aaattgtgag aaacctaatg gaatctttag ctcagggggc tgaagaaccg     3240

aaactaaaat gggaacacat cacaaccctc attgcaagcc tcagagaatt tgtgagatcc     3300

actgaccgaa aaatcatagc caccacactg tcaaagctga aactggagct ggacttcgac     3360

agccatggca ttagccaagt ccaggtggta ctctttggtt ttcaagatgc tgtcaataaa     3420

gttcttcgga atcataacat caagccgcac tggatgtttg ccttagacag tatcattcgg     3480

aaggcggtac agacagccat taccatcctg gttccagaac taaggccaca tttcagcctt     3540

gcatctgaga gtgatactgc tgatcaagaa gacttggatg tagaagatga ccatgaggaa     3600

cagccttcaa atcaaactgt ccgaagacct caggctgtca ttgaagatgc tgtggctacc     3660

tcaggcgtga gcacgctcag ttctactgtg tctcatgatt cccagagtgc tcaccggtca     3720

ctgaatgtac agcttggaag gatgaaaata gaaaccaata gattactgga agaattggtt     3780

cggaaagaga aagaattaca agcactcctt catcgagcta ttgaagaaaa agaccaagaa     3840

attaaacacc tgaagcttaa gtcccaaccc atagaaattc ctgaattgcc tgtatttcat     3900

ctaaattctt ctggcacaaa tactgaagat tctgaactta ccgactggct gagagtgaat     3960

ggagctgatg aagacactat aagccggttt ttggctgaag attatacact attggatgtt     4020

ctctactatg ttacacgtga tgacttaaaa tgcttgagac taaggggagg gatgctgtgc     4080

acactgtgga aggctatcat tgactttcga aacaaacaga cttga                     4125


<210>  368
<211>  3498
<212>  DNA
<213>  Homo sapiens;

<400>  368
atggcgaacg actcccctgc aaaaagtctg gtggacatcg acctctcctc cctgcgggat       60

cctgctggga tttttgagct ggtggaagtg gttggaaatg gcacctatgg acaagtctat      120

aagggtcgac atgttaaaac gggtcagttg gcagccatca aagttatgga tgtcactgag      180

gatgaagagg aagaaatcaa actggagata aatatgctaa agaaatactc tcatcacaga      240

aacattgcaa catattatgg tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa      300

ctctggcttg ttatggagtt ctgtggggct gggtccatta cagaccttgt gaagaacacc      360

aaagggaaca cactcaaaga agactggatc gcttacatct ccagagaaat cctgagggga      420

ctggcacatc ttcacattca tcatgtgatt caccgggata tcaagggcca gaatgtgttg      480

ctgactgaga atgcagaggt gaaacttgtt gactttggtg tgagtgctca gctggacagg      540

actgtggggc ggagaaatac gttcataggc actccctact ggatggctcc tgaggtcatc      600

gcctgtgatg agaacccaga tgccacctat gattacagaa gtgatctttg gtcttgtggc      660

attacagcca ttgagatggc agaaggtgct ccccctctct gtgacatgca tccaatgaga      720

gcactgtttc tcattcccag aaaccctcct ccccggctga agtcaaaaaa atggtcgaag      780

aagtttttta gttttataga agggtgcctg gtgaagaatt acatgcagcg gccctctaca      840

gagcagcttt tgaaacatcc ttttataagg gatcagccaa atgaaaggca agttagaatc      900

cagcttaagg atcatataga tcgtaccagg aagaagagag gcgagaaaga tgaaactgag      960

tatgagtaca gtgggagtga ggaagaagag gaggaagtgc ctgaacagga aggagagcca     1020

agttccattg tgaacgtgcc tggtgagtct actcttcgcc gagatttcct gagactgcag     1080

caggagaaca aggaacgttc cgaggctctt cggagacaac agttactaca ggagcaacag     1140

ctccgggagc aggaagaata taaaaggcaa ctgctggcag agagacagaa gcggattgag     1200

cagcagaaag aacagaggcg acggctagaa gagcaacaaa ggagagagcg ggaagctaga     1260

aggcagcagg aacgtgaaca gcgaaggaga gaacaagaag aaaagaggcg tctagaggag     1320

ttggagagaa ggcgcaaaga agaagaggag aggagacggg cagaagaaga aaagaggaga     1380

gttgaaagag aacaggagta tatcaggcga cagctagaag aggagcagcg gcacttggaa     1440

gtccttcagc agcagctgct ccaggagcag gccatgttac tgcatgacca taggaggccg     1500

cacccgcagc actcgcagca gccgccacca ccgcagcagg aaaggagcaa gccaagcttc     1560

catgctcccg agcccaaagc ccactacgag cctgctgacc gagcgcgaga ggttcctgtg     1620

agaacaacat ctcgctcccc tgttctgtcc cgtcgagatt ccccactgca gggcagtggg     1680

cagcagaata gccaggcagg acagagaaac tccaccagta ttgagcccag gcttctgtgg     1740

gagagagtgg agaagctggt gcccagacct ggcagtggca gctcctcagg gtccagcaac     1800

tcaggatccc agcccgggtc tcaccctggg tctcagagtg gctccgggga acgcttcaga     1860

gtgagatcat catccaagtc tgaaggctct ccatctcagc gcctggaaaa tgcagtgaaa     1920

aaacctgaag ataaaaagga agttttcaga cccctcaagc ctgctgtaag gattgatctg     1980

accgcactgg ccaaagagct tcgagcagtg gaagatgtac ggccacctca caaagtaacg     2040

gactactcct catccagtga ggagtcgggg acgacggatg aggaggacga cgatgtggag     2100

caggaagggg ctgacgagtc cacctcagga ccagaggaca ccagagcagc gtcatctctg     2160

aatttgagca atggtgaaac ggaatctgtg aaaaccatga ttgtccatga tgatgtagaa     2220

agtgagccgg ccatgacccc atccaaggag ggcactctaa tcgtccgcca gactcagtcc     2280

gctagtagca cactccagaa acacaaatct tcctcctcct ttacaccttt tatagacccc     2340

agattactac agatttctcc atctagcgga acaacagtga catctgtggt gggattttcc     2400

tgtgatggga tgagaccaga agccataagg caagatccta cccggaaagg ctcagtggtc     2460

aatgtgaatc ctaccaacac taggccacag agtgacaccc cggagattcg taaatacaag     2520

aagaggttta actctgagat tctgtgtgct gccttatggg gagtgaattt gctagtgggt     2580

acagagagtg gcctgatgct gctggacaga agtggccaag ggaaggtcta tcctcttatc     2640

aaccgaagac gatttcaaca aatggacgta cttgagggct tgaatgtctt ggtgacaata     2700

tctggcaaaa aggataagtt acgtgtctac tatttgtcct ggttaagaaa taaaatactt     2760

cacaatgatc cagaagttga gaagaagcag ggatggacaa ccgtagggga tttggaagga     2820

tgtgtacatt ataaagttgt aaaatatgaa agaatcaaat ttctggtgat tgctttgaag     2880

agttctgtgg aagtctatgc gtgggcacca aagccatatc acaaatttat ggcctttaag     2940

tcatttggag aattggtaca taagccatta ctggtggatc tcactgttga ggaaggccag     3000

aggttgaaag tgatctatgg atcctgtgct ggattccatg ctgttgatgt ggattcagga     3060

tcagtctatg acatttatct accaacacat gtaagaaaga acccacactc tatgatccag     3120

tgtagcatca aaccccatgc aatcatcatc ctccccaata cagatggaat ggagcttctg     3180

gtgtgctatg aagatgaggg ggtttatgta aacacatatg gaaggatcac caaggatgta     3240

gttctacagt ggggagagat gcctacatca gtagcatata ttcgatccaa tcagacaatg     3300

ggctggggag agaaggccat agagatccga tctgtggaaa ctggtcactt ggatggtgtg     3360

ttcatgcaca aaagggctca aagactaaaa ttcttgtgtg aacgcaatga caaggtgttc     3420

tttgcctctg ttcggtctgg tggcagcagt caggtttatt tcatgacctt aggcaggact     3480

tctcttctga gctggtag                                                   3498


<210>  369
<211>  1083
<212>  DNA
<213>  Homo sapiens;

<400>  369
atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac       60

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc      120

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag      180

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat      240

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat      300

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac      360

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc      420

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc      480

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac      540

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg      600

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa      660

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt      720

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct      780

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca      840

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag      900

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt      960

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag     1020

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct     1080

taa                                                                   1083


<210>  370
<211>  1083
<212>  DNA
<213>  Homo sapiens;

<400>  370
atgtctcagg agaggcccac gttctaccgg caggagctga acaagacaat ctgggaggtg       60

cccgagcgtt accagaacct gtctccagtg ggctctggcg cctatggctc tgtgtgtgct      120

gcttttgaca caaaaacggg gttacgtgtg gcagtgaaga agctctccag accatttcag      180

tccatcattc atgcgaaaag aacctacaga gaactgcggt tacttaaaca tatgaaacat      240

gaaaatgtga ttggtctgtt ggacgttttt acacctgcaa ggtctctgga ggaattcaat      300

gatgtgtatc tggtgaccca tctcatgggg gcagatctga acaacattgt gaaatgtcag      360

aagcttacag atgaccatgt tcagttcctt atctaccaaa ttctccgagg tctaaagtat      420

atacattcag ctgacataat tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa      480

gactgtgagc tgaagattct ggattttgga ctggctcggc acacagatga tgaaatgaca      540

ggctacgtgg ccactaggtg gtacagggct cctgagatca tgctgaactg gatgcattac      600

aaccagacag ttgatatttg gtcagtggga tgcataatgg ccgagctgtt gactggaaga      660

acattgtttc ctggtacaga ccatattaac cagcttcagc agattatgcg tctgacagga      720

acaccccccg cttatctcat taacaggatg ccaagccatg aggcaagaaa ctatattcag      780

tctttgactc agatgccgaa gatgaacttt gcgaatgtat ttattggtgc caatcccctg      840

gctgtcgact tgctggagaa gatgcttgta ttggactcag ataagagaat tacagcggcc      900

caagcccttg cacatgccta ctttgctcag taccacgatc ctgatgatga accagtggcc      960

gatccttatg atcagtcctt tgaaagcagg gacctcctta tagatgagtg gaaaagcctg     1020

acctatgatg aagtcatcag ctttgtgcca ccaccccttg accaagaaga gatggagtcc     1080

tga                                                                   1083


<210>  371
<211>  984
<212>  DNA
<213>  Homo sapiens;

<400>  371
atgcctgggc cgacccaaac cctgtcccca aatggcgaga acaacaacga catcatccag       60

gataataacg ggaccatcat tcctttccgg aagcacacag tgcgcgggga gcgttcctac      120

agttggggaa tggcggtcaa tgtgtattct acctcgataa cccaagagac tatgagcaga      180

catgacatca ttgcatgggt taatgacata gtatctttaa actacacaaa agtggaacag      240

ctttgttcag gagcggccta ttgccaattc atggacatgc tcttccctgg ctgcattagt      300

ttgaagaaag taaaatttca agcaaagctg gaacatgaat atattcacaa ttttaaactt      360

ctgcaagcat catttaagcg aatgaacgtt gataaggtaa ttccagtgga gaagctagtg      420

aaaggacgtt tccaggacaa cctggatttt attcaatggt ttaagaaatt ctatgatgct      480

aactacgatg ggaaggagta tgatcctgta gaggcacgac aagggcaaga tgcaattcct      540

cctcctgacc ctggtgaaca gatcttcaac ctgccaaaaa agtctcacca tgcaaactcc      600

cccacagcag gtgcagctaa atcaagtcca gcagctaaac caggatccac accttctcga      660

ccctcatcag ccaaaagggc ttcttccagt ggctcagcat ccaaatccga taaagattta      720

gaaacgcagg tcatacagct taatgaacag gtacattcat taaaacttgc ccttgaaggc      780

gtggaaaagg aaagggattt ctactttggg aagttgagag agatcgagct actctgccaa      840

gaacacgggc aggaaaatga tgacctcgtg cagagactaa tggacatcct gtatgcttca      900

gaagaacacg agggccacac agaagagccg gaagcagagg agcaagccca cgaacagcag      960

cccccgcagc aggaagagta ctga                                             984


<210>  372
<211>  2115
<212>  DNA
<213>  Homo sapiens;

<400>  372
atggagtcta aaccttcaag gattccaaga agaatttctg ttcaaccttc cagctcctta       60

agtgctagga tgatgtctgg aagcagagga agtagtttaa atgataccta tcactcaaga      120

gactcttcat ttagattgga ttctgaatat cagtctacat cagcatcagc atctgcgtca      180

ccatttcaat ctgcatggta tagtgaatct gagataactc agggagcacg ctcaagatcg      240

cagaaccagc aacgggatca tgattcaaaa agacctaaac tttcctgtac aaactgtact      300

acctcagctg ggagaaatgt tggaaatggt ttaaacacat tatcagattc atcttggagg      360

catagtcaag ttcctagatc ttcatcaatg gtacttggat catttggaac agacttaatg      420

agagagagga gagatttgga gagaagaaca gattcctcta ttagtaatct tatggattat      480

agtcaccgaa gtggtgattt cacaacttca tcatatgttc aagacagagt tccttcatat      540

tcacaaggag caagaccaaa agaaaactca atgagcactt tacagttgaa tacatcatcc      600

acaaaccacc aattgccttc tgaacatcag accatactaa gttctaggga ctccagaaat      660

tctttaagat caaatttttc ttcaagagaa tcagaatctt cccgaagcaa tacgcagcct      720

ggattttctt acagttcaag tagagatgaa gccccaatca taagcaattc agaaagggtt      780

gtttcatctc aaagaccatt tcaagaatct tctgacaatg aaggtaggcg gacaacgagg      840

agattgctgt cacgcatagc ttctagcatg tcatctactt ttttttcacg aagatctagt      900

caggattcct tgaatacaag atcattgaat tctgaaaatt cttacgtttc tccaagaatc      960

ttgacagctt cacagtcccg tagtaatgta ccatcagctt ctgaagttcc cgataatagg     1020

gcatctgaag cttctcaggg atttcgattt cttaggcgaa gatggggttt gtcatctctt     1080

agccacaatc atagctctga gtcagattca gaaaatttta accaagaatc tgaaggtaga     1140

aatacaggac catggttatc ttcctcactt agaaatagat gcacaccttt gttctctaga     1200

aggaggcgag agggaagaga tgaatcttca aggataccta cctctgatac atcatctaga     1260

tctcatattt ttagaagaga atcaaatgaa gtggttcacc ttgaagcaca gaatgatcct     1320

cttggagctg ctgccaacag accacaagca tctgcagcat caagcagtgc cacaacaggt     1380

ggctctacat cagattcggc tcaaggtgga agaaatacag gaatatcagg gattcttcct     1440

ggttccttat tccggtttgc agtccctcca gcacttggga gtaatttgac cgacaatgtc     1500

atgatcacag tagatattat tccttcaggt tggaattcag ctgatggtaa aagtgataaa     1560

actaaaagtg cgccttcaag agatccagaa agattgcaga aaataaaaga gagcctcctt     1620

ttagaggact cagaagaaga agaaggtgac ttatgtagaa tttgtcaaat ggcagctgca     1680

tcatcatcta atttgctgat agagccatgc aagtgcacag gaagtttgca gtatgtccac     1740

caagactgta tgaaaaagtg gttacaggcc aaaattaact ctggttcttc attagaagct     1800

gtaaccacct gtgaactatg taaagagaag ttggagctta acctggagga ttttgatatt     1860

catgaactac atagagctca tgcaaatgaa caagctgagt atgagtttat cagctctggt     1920

ctctacctag tggtgttatt gcacttgtgc gaacaaagct tttctgatat gatgggaaat     1980

acaaatgaac caagcacacg tgtccgattt attaaccttg caagaactct tcaggcacat     2040

atggaagatc tcgaaacttc agaggatgat tccgaagaag acggagacca taacaggaca     2100

tttgatattg cctaa                                                      2115


<210>  373
<211>  876
<212>  DNA
<213>  Homo sapiens;

<400>  373
atgagcatgc cactgcatca gatctctgcc attccatccc aggatgccat ctctgctaga       60

gtctacagaa gtaagaccaa agaaaaggag agggaagaac agaatgagaa gactttggga      120

catttcatga gtcattcaag caacatttct aaggctggga gtcctccgtc agcatcagct      180

ccggctccgg tgtcctcctt ctctcgcact tctatcacgc catccagcca ggacatctgc      240

aggatctgcc actgtgaagg agatgatgag agccccctga tcaccccctg ccactgcaca      300

ggaagcctcc acttcgtgca ccaggcctgc ctgcagcagt ggatcaagag ctccgacacg      360

cgctgctgcg agctctgcaa gtatgagttc atcatggaga ccaagctgaa gccactgaga      420

aaatgggaga agttgcagat gacgtccagc gagcgcagga agatcatgtg ctcagtgaca      480

ttccacgtca ttgccatcac atgtgtggtc tggtccttgt atgtgctcat tgaccgtact      540

gctgaggaga tcaagcaggg gcaggcaaca ggaatcctag aatggccctt ttggactaaa      600

ttggtggttg tggccatcgg cttcaccgga ggacttcttt ttatgtatgt tcagtgtaaa      660

gtgtatgtgc aattgtggaa gagactcaag gcctataata gagtgatcta tgttcaaaac      720

tgtccagaaa caagcaaaaa gaatattttt gaaaaatctc cactaacaga gcccaacttt      780

gaaaataaac atggatatgg aatctgtcat tccgacacaa actcttcttg ttgcacagag      840

cctgaagaca ctggagcaga aatcattcac gtctga                                876


<210>  374
<211>  2190
<212>  DNA
<213>  Homo sapiens;

<400>  374
atgtccacta ggaccccatt gccaacggtg aatgaacgag acactgaaaa ccacacgtca       60

catggagatg ggcgtcaaga agttacctct cgtaccagcc gctcaggagc tcggtgtaga      120

aactctatag cctcctgtgc agatgaacaa cctcacatcg gaaactacag actgttgaaa      180

acaatcggca aggggaattt tgcaaaagta aaattggcaa gacatatcct tacaggcaga      240

gaggttgcaa taaaaataat tgacaaaact cagttgaatc caacaagtct acaaaagctc      300

ttcagagaag taagaataat gaagatttta aatcatccca atatagtgaa gttattcgaa      360

gtcattgaaa ctgaaaaaac actctaccta atcatggaat atgcaagtgg aggtgaagta      420

tttgactatt tggttgcaca tggcaggatg aaggaaaaag aagcaagatc taaatttaga      480

cagattgtgt ctgcagttca atactgccat cagaaacgga tcgtacatcg agacctcaag      540

gctgaaaatc tattgttaga tgccgatatg aacattaaaa tagcagattt cggttttagc      600

aatgaattta ctgttggcgg taaactcgac acgttttgtg gcagtcctcc atacgcagca      660

cctgagctct tccagggcaa gaaatatgac gggccagaag tggatgtgtg gagtctgggg      720

gtcattttat acacactagt cagtggctca cttccctttg atgggcaaaa cctaaaggaa      780

ctgagagaga gagtattaag agggaaatac agaattccct tctacatgtc tacagactgt      840

gaaaaccttc tcaaacgttt cctggtgcta aatccaatta aacgcggcac tctagagcaa      900

atcatgaagg acaggtggat caatgcaggg catgaagaag atgaactcaa accatttgtt      960

gaaccagagc tagacatctc agaccaaaaa agaatagata ttatggtggg aatgggatat     1020

tcacaagaag aaattcaaga atctcttagt aagatgaaat acgatgaaat cacagctaca     1080

tatttgttat tggggagaaa atcttcagag ctggatgcta gtgattccag ttctagcagc     1140

aatctttcac ttgctaaggt taggccgagc agtgatctca acaacagtac tggccagtct     1200

cctcaccaca aagtgcagag aagtgtttct tcaagccaaa agcaaagacg ctacagtgac     1260

catgctggac cagctattcc ttctgttgtg gcgtatccga aaaggagtca gaccagcact     1320

gcagatagtg acctcaaaga agatggaatt tcctcccgga aatcaagtgg cagtgctgtt     1380

ggaggaaagg gaattgctcc agccagtccc atgcttggga atgcaagtaa tcctaataag     1440

gcggatattc ctgaacgcaa gaaaagctcc actgtcccta gtagtaacac agcatctggt     1500

ggaatgacac gacgaaatac ttatgtttgc agtgagagaa ctacagctga tagacactca     1560

gtgattcaga atggcaaaga aaacagcact attcctgatc agagaactcc agttgcttca     1620

acacacagta tcagtagtgc agccacccca gatcgaatcc gcttcccaag aggcactgcc     1680

agtcgtagca ctttccacgg ccagccccgg gaacggcgaa ccgcaacata taatggccct     1740

cctgcctctc ccagcctgtc ccatgaagcc acaccattgt cccagactcg aagccgaggc     1800

tccactaatc tctttagtaa attaacttca aaactcacaa ggagtcgcaa tgtatctgct     1860

gagcaaaaag atgaaaacaa agaagcaaag cctcgatccc tacgcttcac ctggagcatg     1920

aaaaccacta gttcaatgga tcccggggac atgatgcggg aaatccgcaa agtgttggac     1980

gccaataact gcgactatga gcagagggag cgcttcttgc tcttctgcgt ccacggagat     2040

gggcacgcgg agaacctcgt gcagtgggaa atggaagtgt gcaagctgcc aagactgtct     2100

ctgaacgggg tccggtttaa gcggatatcg gggacatcca tagccttcaa aaatattgct     2160

tccaaaattg ccaatgagct aaagctgtaa                                      2190


<210>  375
<211>  3930
<212>  DNA
<213>  Homo sapiens;

<400>  375
atggacgagt cgagcctcct gcggcgccgc gggctccaga aggagctgag cctgccacgc       60

cgaggacgtg gctgccgcag cgggaaccgc aagagcttgg tggtaggaac gccctccccg      120

accctctccc ggcccctgtc gccattgtcg gtcccaacgg caggcagcag ccccttggat      180

agtcctcgga atttctcggc tgcctctgcc ctaaatttcc cctttgcccg gagggcagac      240

ggcagaagat ggtccctcgc gtctctccca tcttccggct atggaaccaa cacacccagc      300

tccaccctct cgtcaagctc atcctcccgg gaacgtctcc accagcttcc cttccagccg      360

acgccggacg agctgcactt cctgtccaag cacttccgca gctcagagaa tgtgcttgat      420

gaggaaggcg gccggtcacc ccgcctccga ccccgctctc gcagtctcag cccgggccgt      480

gcaacgggga ccttcgacaa tgagattgtc atgatgaatc acgtgtaccg ggagaggttc      540

cccaaggcca cagcacagat ggagggccgt ctgcaggagt tcctgacggc ctacgcgccc      600

ggcgcccggc tggcgctggc tgatggcgtc ttgggcttca tccaccacca gatcgtcgag      660

ctggcccgag actgcttggc caagtctggc gagaacctcg tcacctcccg ctacttccta      720

gagatgcagg agaagctgga gcggcttctg caggatgccc atgagcgttc ggacagtgag      780

gaggtcagct tcatcgtcca gcttgtccgg aaactgctga tcatcatctc acggccagct      840

cggctgctgg agtgtctgga gtttgaccct gaggaatttt accacctgct ggaggcggct      900

gagggccatg cgcgggaggg ccaaggcatt aagactgacc ttccacagta catcattggg      960

cagctgggcc tggccaagga ccccctggag gagatggtgc cactgagtca cctcgaagaa     1020

gaacagcccc cagcacctga gtccccagag agccgcgccc tggtcggcca gtcacggagg     1080

aagccatgcg aaagcgactt tgagaccatc aaactcatta gcaacggagc ctatggggcc     1140

gtctacctgg tgcggcaccg tgacacacgg cagcgctttg ccatcaagaa gatcaacaaa     1200

cagaacttga tcctgcgtaa ccagatccag caggtctttg tggagcgtga cattctcacc     1260

tttgccgaga acccctttgt ggtcagcatg ttctgctcct ttgagacccg gcgccaccta     1320

tgtatggtca tggaatacgt ggaaggcggc gactgcgcca cgctcctgaa gaacatgggc     1380

ccgctgcccg tggacatggc ccgcctgtac ttcgccgaga cggtgttggc gctggagtac     1440

ctgcataact atggcatcgt gcaccgtgac ctcaaaccag acaatctgct catcacctcg     1500

cttggccaca tcaagctcac ggacttcggc ctgtccaaga tcggcctcat gagcatggcc     1560

accaacctct atgagggcca catcgagaag gacgcccgag agttcatcga caagcaggtg     1620

tgtgggacgc cggagtacat agcccccgag gtgatcttcc gccagggcta tgggaagcca     1680

gtggactggt gggccatggg cgtcgtcctc tatgagtttc tggtgggctg cgtgcctttc     1740

tttggagata cccccgagga actcttcggt caggtggtca gcgatgagat catgtggcca     1800

gagggagatg aggcccttcc agcagacgcc caggacctca tcaccaggtt gctccggcag     1860

agcccgctgg accgtctggg cactggtggc acccacgaag tgaagcagca cccctttttc     1920

ctggccctgg actgggcagg gcttctccga cacaaagccg agttcgtgcc ccagctcgaa     1980

gctgaggatg ataccagcta ctttgacaca cgttcggaac gttaccgcca tctgggctcc     2040

gaggacgacg agaccaatga tgaagaatcg tccacagaga tcccccagtt ctcctcctgc     2100

tcccaccggt tcagcaaggt ctacagcagc tctgagttcc tggccgtcca gcccactcct     2160

accttcgctg aaaggagctt cagtgaagac cgggaggagg ggtgggagcg cagcgaagtg     2220

gactatggcc gccggctgag tgctgacatc cggctgaggt cctggacatc ctctggatcc     2280

tcctgtcagt catcttcgtc ccagcccgag cggggtccca gcccatctct cctgaatacc     2340

atcagcctgg acacaatgcc caagtttgcc ttctcatcag aggatgaggg ggtaggccca     2400

ggccctgcag gccccaagag gcccgtcttc attctagggg agcctgaccc cccaccagcg     2460

gccaccccag tgatgcccaa gccctcgagc ctttctgccg acacagctgc tctcagccac     2520

gcccgcctac ggagcaatag catcggcgcc cgacactcca caccaaggcc tctggatgcc     2580

ggccggggcc gccgccttgg gggcccaaga gacccagccc ctgagaagtc cagagcctcc     2640

tccagcggtg gcagtggtgg cggcagtggg ggccgcgtgc ccaagtcagc ctctgtctct     2700

gccctgtccc tcatcatcac ggcagatgat ggcagcggcg gccccctcat gagccccctt     2760

tccccgcgct ctctgtcctc gaacccgtcg tcccgtgact cttcgccgag ccgagacccg     2820

tcccccgtgt gtggcagcct gcggcccccc atcgttatcc acagctctgg caagaagtac     2880

ggcttcagcc tgcgggcgat ccgcgtctac atgggtgata gcgacgtcta cactgtgcac     2940

cacgtcgtct ggagtgtgga ggacggaagc cccgcccagg aggcgggcct gcgggctggg     3000

gacctcatca cccacatcaa cggggagtca gtgctggggc tggtgcacat ggacgtcgtg     3060

gagctgctgc tgaagagcgg caacaagata tccctgcgga ccacagccct ggagaacacc     3120

tccatcaagg tgggccccgc ccggaagaat gtggccaagg gccgcatggc acgcaggagc     3180

aagaggagcc gtcggcggga gacccaggat cggcggaagt cacttttcaa gaagatctcc     3240

aagcagacct ccgtgctgca caccagccgc agcttctcct ccggactcca ccactcactg     3300

tcatccagtg agagcctccc cggctcgccc acccacagcc tctcccccag ccccaccact     3360

ccctgccgaa gcccagcccc tgatgtccca gcagatacca ctgcatcccc acccagcgca     3420

tccccgagct ccagcagccc cgcctcccca gctgctgctg gccacacccg ccccagctcc     3480

ctgcacggcc tggctgccaa gcttgggcca ccccgcccca agactggccg ccgcaagtcc     3540

accagcagca tcccgccctc cccgctggcc tgcccgccca tctccgcgcc cccaccccgc     3600

tcgccctcgc ccctgcccgg gcacccgccc gcacctgccc gatccccgcg gctgcgccgg     3660

ggccagtcag ctgacaagct gggcacaggg gagcggctgg atggggaggc ggggcggcgc     3720

actcgtgggc cagaggccga gctcgtggtc atgcggcggc tgcacctgtc cgagcgccga     3780

gactccttca agaagcagga ggccgtgcag gaggttagct tcgatgagcc gcaggaggag     3840

gccactgggc tgcccacctc agtgccacag atcgccgtgg agggcgagga agccgtgcca     3900

gtagctctcg ggcccaccgg aagagactga                                      3930


<210>  376
<211>  483
<212>  DNA
<213>  Homo sapiens;

<400>  376
atgagcgata acgatgacat cgaggtggag agcgacgaag agcaaccgag gtttcaatct       60

gcggctgaca aacgggctca tcataatgca ctggaacgaa aacgtaggga ccacatcaaa      120

gacagctttc acagtttgcg ggactcagtc ccatcactcc aaggagagaa ggcatcccgg      180

gcccaaatcc tagacaaagc cacagaatat atccagtata tgcgaaggaa aaaccacaca      240

caccagcaag atattgacga cctcaagcgg cagaatgctc ttctggagca gcaagtccgt      300

gcactggaga aggcgaggtc aagtgcccaa ctgcagacca actacccctc ctcagacaac      360

agcctctaca ccaacgccaa gggcagcacc atctctgcct tcgatggggg ctcggactcc      420

agctcggagt ctgagcctga agagccccaa agcaggaaga agctccggat ggaggccagc      480

taa                                                                    483


<210>  377
<211>  561
<212>  DNA
<213>  Homo sapiens;

<400>  377
atggcgtcac agaagagacc ctcccagagg cacggatcca agtacctggc cacagcaagt       60

accatggacc atgccaggca tggcttcctc ccaaggcaca gagacacggg catccttgac      120

tccatcgggc gcttctttgg cggtgacagg ggtgcgccca agcggggctc tggcaaggta      180

ccctggctaa agccgggccg gagccctctg ccctctcatg cccgcagcca gcctgggctg      240

tgcaacatgt acaaggactc acaccacccg gcaagaactg ctcactacgg ctccctgccc      300

cagaagtcac acggccggac ccaagatgaa aaccccgtag tccacttctt caagaacatt      360

gtgacgcctc gcacaccacc cccgtcgcag ggaaaggggg ccgaaggcca gagaccagga      420

tttggctacg gaggcagagc gtccgactat aaatcggctc acaagggatt caagggagtc      480

gatgcccagg gcacgctttc caaaattttt aagctgggag gaagagatag tcgctctgga      540

tcacccatgg ctagacgctg a                                                561


<210>  378
<211>  2637
<212>  DNA
<213>  Homo sapiens;

<400>  378
atggatctgg ataaaccatc tgtttggggc tcattaaaac agcggaccag gccattgttg       60

atcaacttga gcaagaagaa ggtgaaaaag aacccaagta agcccccaga tctacgggca      120

aggcatcact tggaccgccg tctcagcctc tctgtgcctg atctcctgga ggctgaggcc      180

ttggccccag agggccggcc ttactccggg ccacagtctt cctacacctc ggtgcccagc      240

agtctgtcca ctgcagggat ctttcccaag agcagcagta gctccttgaa acagtctgaa      300

gaagaattgg attggagcca ggaagaagcc agtcacctcc atgtggtgga aacagactca      360

gaggaggcct atgcctctcc tgctgagcgg agacgggtgt ccagcaacgg catctttgat      420

cttcagaaaa cttcccttgg aggggatgca ccagaagagc cagagaagct atgtggaagc      480

agtgacctga atgcttctat gacatctcaa cattttgaag aacaatctgt accgggggaa      540

gccagtgatg gcttgagtaa cctccccagc ccttttgcgt acctcctcac catacacctg      600

aaggaaggcc ggaacctggt tgtccgagat cgctgtggca caagtgatcc ttatgtgaaa      660

tttaagctga atgggaagac gctgtacaaa agtaaagtca tatataagaa cttgaaccca      720

gtatgggatg agatagttgt attgccaatc caaagccttg atcaaaagct acgtgtgaag      780

gtatatgatc gagatttaac cacatctgat ttcatgggtt ctgcatttgt cattctcagt      840

gatcttgagc ttaacagaac aactgaacat attttaaaac tggaagatcc aaacagttta      900

gaagatgaca tgggagtgat cgtgttaaat ttgaacctag tggtaaaaca gggtgatttc      960

aagagacacc gttggtcaaa tcggaagcga ttaagtgcca gcaagtcctc tttgatacgc     1020

aacctacggc tctctgagtc cttgaaaaag aaccaactct ggaacgggat tataagtata     1080

actttgttgg aagggaagaa tgtctcagga ggaagcatga cagagatgtt tgtccagtta     1140

aaactgggag atcagaggta taaaagtaag acactgtgta agagtgcaaa tccgcagtgg     1200

caggaacagt ttgactttca ctacttctct gacaggatgg gcattttgga cattgaagtg     1260

tggggaaagg acaacaaaaa gcatgaggaa cgtctgggca cgtgtaaagt ggatatctcg     1320

gcactccctc tgaagcaagc caactgcctg gagctgccac tggacagctg tctgggggct     1380

ctccttatgt tggtcacact tacaccctgt gcgggggtct ccgtctctga tctgtgtgtc     1440

tgccccttag cagacctcag cgaaagaaag cagattaccc agcgatattg cttacagaac     1500

tccctgaaag atgtgaaaga cgtcggcatt ctacaagtga aggttttaaa ggcagcagat     1560

ctcttagcgg cagatttctc agggaagagt gacccatttt gcttgttgga gttaggcaat     1620

gaccgacttc agacgcatac cgtctacaaa aacctcaacc ctgaatggaa caaagttttt     1680

acatttccca ttaaagatat ccatgatgtt ttggaagtga cagtgtttga tgaagatgga     1740

gataaacccc cagattttct tggaaaagtt gccattccct tgctgtccat tagagatgga     1800

caaccgaatt gttatgtact aaagaataaa gatttagaac aagcttttaa aggagttatt     1860

tacttagaga tggaccttat atataatccg gtgaaagcaa gtattaggac ttttactccc     1920

cgggaaaagc gctttgttga agacagccgc aagctgtcca aaaagatctt atcaagagat     1980

gtggaccgtg tgaaaagaat cactatggca atatggaata caatgcagtt ccttaaaagc     2040

tgcttccagt gggaatccac attaagaagt acaatagcat tcgcggtatt tttgatcact     2100

gtctggaatt ttgaactata tatgatcccc ttggcattgt tgctgatctt tgtctacaat     2160

ttcatcagac ctgtgaaagg caaggtcagc agcatccagg acagccagga gagcacagac     2220

atagatgacg aggaggatga agatgacaag gaatctgaga aaaaggggtt gattgaaaga     2280

atctatatgg tacaggatat tgtttcaact gttcaaaacg tcttggagga aatagcttct     2340

tttggagaaa ggattaagaa cacatttaac tggacggtcc ccttcctttc atctctggcc     2400

tgtttgattc tggcagcagc caccatcatt ttgtatttca ttccactgcg gtacatcatt     2460

ttaatctggg gcataaataa atttactaag aagcttcgaa atccctattc catcgacaat     2520

aatgagctac tagacttcct ctctagggta ccgtctgatg ttcaaaaggt gcagtatgca     2580

gaattgaaac tctgcagcag ccacagcccc ctgcggaaga agcgcagcgc tctctag        2637


<210>  379
<211>  6525
<212>  DNA
<213>  Homo sapiens;

<400>  379
atgagtgcct ccttcgtgcc gaacggggcc agcctggaag attgtcactg taacctcttc       60

tgcctggctg acttgacagg aattaagtgg aaaaaatatg tatggcaagg cccaacttct      120

gcccctattc tgtttcctgt gacagaagaa gaccccattt tgagcagttt tagtcgctgc      180

cttaaggcag atgtacttgg tgtttggcgg cgagatcaaa gacctggaag aagagaattg      240

tggatatttt ggtggggtga agaccccagt tttgctgacc ttattcacca tgacttatca      300

gaagaagaag atggagtgtg ggagaatgga ctttcctatg aatgccgtac tctgcttttc      360

aaagcagttc acaatctatt ggaacggtgt ttaatgaaca ggaattttgt acgtattggc      420

aagtggtttg taaagcctta tgaaaaagat gaaaaaccta taaataaaag tgaacacttg      480

tcctgctcct tcaccttttt cttgcatgga gacagcaatg tttgtaccag tgtggaaatt      540

aaccaacatc aacctgtata ccttctcagt gaagagcata tcacccttgc tcaacagtct      600

aatagcccat ttcaagttat cttatgccca tttggactaa atggcactct cacaggacag      660

gcattcaaga tgtctgattc agctacaaaa aaattaattg gtgaatggaa acagttctat      720

cctatctcat gttgcttgaa ggagatgtct gaagaaaaac aggaagatat ggattgggaa      780

gatgattctt tagctgcagt agaagttctt gttgctggtg tccgaatgat ctacccagca      840

tgctttgttc tagtccctca gtcagacatt cctactccta gccctgtggg atccactcac      900

tgttcatctt cttgcttggg tgtccaccaa gtgcctgctt ccacaagaga tcctgctatg      960

tcttcggtta cgcttacacc acctacgtct cctgaggaag tccaaacagt tgatcctcag     1020

tctgtccaga agtgggtcaa attttcttca gtatctgatg gcttcaactc cgatagtact     1080

agccaccatg gtgggaaaat acccagaaaa ttagcaaatc atgtggtgga tagagtttgg     1140

caagaatgca atatgaacag agcacagaac aagaggaagt attctgcttc atcaggtggt     1200

ctatgcgaag aagcgacagc tgctaaagtg gcatcctggg attttgttga agccacacaa     1260

agaacaaatt gcagttgttt gaggcacaaa aatctcaagt caagaaatgc tggacaacaa     1320

ggacaggcac catctttagg tcagcaacaa caaatacttc ctaagcacaa gaccaatgag     1380

aagcaagaaa agagtgaaaa gccacagaaa cgccccttga ctccttttca ccatcgtgtg     1440

tctgttagtg atgatgttgg catggacgca gattcagcca gccaaagact tgtgatctct     1500

gctccagaca gtcaagtgag attttcaaat atccgaacta atgatgtagc aaagactcct     1560

cagatgcatg gcaccgaaat ggcaaattca cctcaaccac ccccacttag tcctcaccct     1620

tgtgatgtgg ttgatgaagg agtgactaaa acaccttcaa ctcctcagag tcaacatttt     1680

tatcaaatgc caacaccaga tcccttggtt ccttctaaac caatggaaga taggatagac     1740

agtttgtccc agtctttccc acctcaatat caggaagctg tagaacctac agtatatgtt     1800

ggtacagcag taaacttgga agaagatgaa gccaatatag cctggaagta ttacaagttc     1860

ccaaagaaaa aagatgtaga gtttttacca cctcaacttc caagtgataa attcaaggat     1920

gatccagttg gaccttttgg acaggaaagt gtaacatcag ttacagagtt aatggtgcaa     1980

tgtaagaaac ctttaaaagt ttctgatgaa ttagtgcagc aatatcaaat taaaaaccag     2040

tgtctttcag caatagcatc tgatgcagaa caagaaccta aaattgatcc atatgcattt     2100

gttgaaggag atgaggaatt cctttttcct gataaaaaag atagacaaaa tagtgagaga     2160

gaagctggaa aaaaacacaa ggtagaagat gggacatcta gtgtaacagt gttatcacat     2220

gaagaagatg ctatgtcatt atttagtccc tctatcaagc aagatgctcc acgccctact     2280

agtcatgccc gtcctccatc aacaagtttg atttatgact cagacctggc tgtctcttat     2340

actgaccttg ataatctctt caattctgat gaagatgaac taacacctgg atctaaaaaa     2400

tcagcaaatg gatcagatga taaagccagc tgcaaggaat caaagacagg aaatctggac     2460

ccgttatctt gcataagcac tgcagatctt cataaaatgt atcctacacc accatcattg     2520

gaacaacata ttatgggatt ttccccaatg aatatgaata ataaagaata tggtagtatg     2580

gatacaacac ctggaggaac tgttctagaa ggaaatagtt ctagtatagg agcgcagttc     2640

aaaattgagg ttgatgaggg attctgtagc cccaaacctt ctgaaattaa agatttttct     2700

tatgtctata agcctgaaaa ttgtcaaatt ctagtgggat gttccatgtt tgcacctcta     2760

aaaactctac caagccaata tctgccccct atcaaattgc cagaagagtg tatttaccgt     2820

cagagttgga ctgttggaaa attggaattg ctttcttcag ggccttcaat gccattcatc     2880

aaagagggtg atggaagtaa tatggatcaa gaatatggca ctgcttatac acctcaaact     2940

catacttctt ttgggatgcc tcctagcagt gcacctccta gtaacagcgg agcaggaatt     3000

cttccttctc catccacccc tcggtttcca actccaagga ctccaaggac tcctcggact     3060

cctcgtggag ctggtggacc tgctagtgct caaggttcag tcaaatatga aaattcagac     3120

ttgtattcac cagcttctac cccatctaca tgcagacccc ttaattctgt tgaacctgca     3180

actgtccctt ccatccctga agcacacagt ctttatgtaa acctcatcct ttcagaatca     3240

gttatgaatt tgtttaaaga ctgtaacttt gatagttgtt gcatctgtgt ttgcaacatg     3300

aacatcaagg gtgccgatgt tggagtttac attccagatc caacgcagga agcacaatat     3360

aggtgtacct gtggcttcag tgctgtcatg aacagaaaat ttggaaacaa ttcaggatta     3420

tttcttgaag atgaactaga tatcatagga cgcaatacag actgtggcaa agaagcagaa     3480

aaacgttttg aagctctcag ggctacctct gctgaacatg ttaatggagg actaaaggaa     3540

tctgaaaaat tatctgatga tttgatatta ttgctacaag atcagtgcac taatttattt     3600

tcaccctttg gagcagcaga ccaagatcct tttcctaaaa gtggtgtaat tagcaattgg     3660

gtacgtgttg aagagcgtga ctgttgcaat gactgctacc ttgcattaga acatgggcgt     3720

cagttcatgg ataacatgtc aggaggaaaa gttgatgaag cacttgtgaa aagttcatgc     3780

ttacacccct ggtccaaaag aaacgatgtg agtatgcagt gctcacagga tatacttcga     3840

atgctcctct ctcttcagcc agttcttcag gatgccattc agaaaaaaag aacagtaaga     3900

ccttggggtg ttcagggtcc tctcacttgg caacaatttc ataaaatggc tggccgaggc     3960

tcttatggaa ctgatgaatc cccagaacca ctgccaatcc ccacattttt gttgggttat     4020

gattatgatt atctggtgct ttctccattt gctcttcctt attgggagag acttatgctg     4080

gaaccctatg gatctcaaag agatatagcc tatgttgtac tgtgtccaga aaatgaagcc     4140

ttgttaaatg gagcaaaaag cttttttaga gatcttactg caatatatga gtcctgtcga     4200

ttaggtcaac atagacctgt ttctcgactg ttaacagatg ggatcatgag agttggatct     4260

actgcatcaa agaaactatc agaaaagttg gtagcagaat ggttttctca ggcagctgac     4320

ggtaacaatg aagcattttc taaactcaag ctttatgcac aagtctgcag atatgaccta     4380

ggtccttatc ttgcttccct gccattggac agctctctac tttcccagcc aaatttagtt     4440

gcccctacaa gtcagtcttt gattactcca cctcagatga caaatactgg aaatgctaat     4500

actccatctg ccaccttagc atctgcagcg agcagcacta tgacagtgac ttcaggtgtt     4560

gccatatcta cttcagttgc cacagctaat tcaactttga ccacagcttc aacttcatct     4620

tcatcatcct ccaacttgaa tagtggagta tcatcaaata aactaccttc gtttccaccc     4680

tttggcagta tgaacagtaa tgctgcagga tccatgtcta cacaagcaaa tacagttcag     4740

agtggtcagc taggagggca acagacatca gctctacaga cagctgggat ttctggagaa     4800

tcatcttcac ttcccactca gccgcatcct gatgtgtctg aaagcacgat ggatcgggat     4860

aaagtgggaa tccccacaga tggtgattca catgcagtca cgtatccacc tgcaattgtt     4920

gtttatataa ttgatccttt tacatacgaa aatacagacg agagcactaa ctcttctagt     4980

gtgtggacat tggggctact tcgatgcttt ctagaaatgg tccagactct tcctcctcat     5040

atcaagagta ctgtttctgt acagattatt ccttgtcagt acctgttgca acctgtgaag     5100

catgaagata gagaaatcta tccccagcat ttaaaatccc tggctttttc ggcctttacc     5160

cagtgtcgga ggccacttcc aacatcaacc aatgtgaaaa cattgactgg ctttggtcca     5220

ggtttagcca tggaaactgc ccttagaagt cctgatagac cagagtgtat tcgactttat     5280

gcacctcctt ttattctggc tccagtgaag gacaaacaga cagagctagg agaaacattt     5340

ggagaagctg gacagaaata taatgttctt tttgtgggat actgtttatc acatgatcaa     5400

aggtggattc ttgcatcttg cacagatcta tatggagaac ttttagaaac ttgtatcatt     5460

aacatcgatg ttccaaatag ggctcgtcgg aaaaaaagtt ctgctagaaa atttggtcta     5520

cagaaacttt gggagtggtg cttaggactt gtacaaatga gttcattgcc atggagagtt     5580

gtaattggtc gtctaggaag gattggtcat ggagaattga aagattggag ctgtttgctg     5640

agtcgtcgaa acttgcagtc tctaagtaaa aggctcaaag acatgtgtag aatgtgtggt     5700

atatctgctg cagactcccc tagcattctc agtgcttgct tggtggcaat ggagccgcaa     5760

ggctcttttg ttattatgcc agattctgtg tcaactggtt ctgtatttgg aagaagcacg     5820

actctaaata tgcagacatc tcagctaaat accccacagg atacatcatg tactcatata     5880

cttgtgtttc ctacttctgc ttctgtgcaa gtagcttcag ctacttatac cactgaaaat     5940

ttggatttag ctttcaatcc caacaatgat ggagcagatg gaatgggtat ctttgatttg     6000

ttagacacag gagatgatct tgaccctgat atcattaata tccttcctgc ttctccaact     6060

ggttctcctg tacattctcc aggatctcat tacccccatg gaggtgatgc gggcaagggt     6120

cagagtactg atcggctact atcaacagaa cctcatgagg aagtacctaa tattcttcag     6180

caaccattgg cccttggtta ctttgtatca actgccaaag caggtccatt acctgactgg     6240

ttctggtcag catgtcctca agcacaatat cagtgtcccc tttttcttaa ggcctctttg     6300

cacctccacg tgccttcagt gcaatctgac gagctgcttc acagtaaaca ctcccaccca     6360

cttgactcaa atcagacttc agatgtcctc aggtttgttt tggaacagta caatgcactc     6420

tcctggctaa cctgtgaccc tgcaacccag gacagacgct catgtctccc aattcatttt     6480

gtggtgctga atcagttata taactttatt atgaatatgc tgtga                     6525


<210>  380
<211>  1500
<212>  DNA
<213>  Homo sapiens;

<400>  380
atggggcgga agaaaataca aatcacacgc ataatggatg aaaggaaccg acaggtcact       60

tttacaaaga gaaagtttgg attaatgaag aaagcctatg aacttagtgt gctctgtgac      120

tgtgaaatag cactcatcat tttcaacagc tctaacaaac tgtttcaata tgctagcact      180

gatatggaca aagttcttct caagtataca gaatataatg aacctcatga aagcagaacc      240

aactcggata ttgttgaggc tctgaacaag aaggaacaca gagggtgcga cagcccagac      300

cctgatactt catatgtgct aactccacat acagaagaaa aatataaaaa aattaatgag      360

gaatttgata atatgatgcg gaatcataaa atcgcacctg gtctgccacc tcagaacttt      420

tcaatgtctg tcacagttcc agtgaccagc cccaatgctt tgtcctacac taacccaggg      480

agttcactgg tgtccccatc tttggcagcc agctcaacgt taacagattc aagcatgctc      540

tctccacctc aaaccacatt acatagaaat gtgtctcctg gagctcctca gagaccacca      600

agtactggca atgcaggtgg gatgttgagc actacagacc tcacagtgcc aaatggagct      660

ggaagcagtc cagtggggaa tggatttgta aactcaagag cttctccaaa tttgattgga      720

gctactggtg caaatagctt aggcaaagtc atgcctacaa agtctccccc tccaccaggt      780

ggtggtaatc ttggaatgaa cagtaggaaa ccagatcttc gagttgtcat ccccccttca      840

agcaagggca tgatgcctcc actaaatacc cagaggatca gtagttctca agccactcaa      900

cctcttgcta ccccagtcgt gtctgtgaca accccaagct tgcctccgca aggacttgtg      960

tactcagcaa tgccgactgc ctacaacact gattattcac tgaccagcgc tgacctgtca     1020

gcccttcaag gcttcaactc gccaggaatg ctgtcgctgg gacaggtgtc ggcctggcag     1080

cagcaccacc taggacaagc agccctcagc tctcttgttg ctggagggca gttatctcag     1140

ggttccaatt tatccattaa taccaaccaa aacatcagca tcaagtccga accgatttca     1200

cctcctcggg atcgtatgac cccatcgggc ttccagcagc agcagcagca gcagcagcag     1260

cagcagccgc cgccaccacc gcagccccag ccacaacccc cgcagcccca gccccgacag     1320

gaaatggggc gctcccctgt ggacagtctg agcagctcta gtagctccta tgatggcagt     1380

gatcgggagg atccacgggg cgacttccat tctccaattg tgcttggccg acccccaaac     1440

actgaggaca gagaaagccc ttctgtaaag cgaatgagga tggacgcgtg ggtgacctaa     1500


<210>  381
<211>  1743
<212>  DNA
<213>  Homo sapiens;

<400>  381
atgtcggaca cgtggagctc tatccaggcc cacaagaagc agctggactc tctgcgggag       60

aggctgcagc ggaggcggaa gcaggactcg gggcacttgg atctacggaa tccagaggca      120

gcattgtctc caaccttccg tagtgacagc ccagtgccta ctgcacccac ctctggtggc      180

cctaagccca gcacagcttc agcagttcct gaattagcta cagatcctga gttagagaag      240

aagttgctac accacctctc tgatctggcc ttaacattgc ccactgatgc tgtgtccatc      300

tgtcttgcca tctccacgcc agatgctcct gccactcaag atggggtaga aagcctcctg      360

cagaagtttg cagctcagga gttgattgag gtaaagcgag gtctcctaca agatgatgca      420

catcctactc ttgtaaccta tgctgaccat tccaagctct ctgccatgat gggtgctgtg      480

gcagaaaaga agggccctgg ggaggtagca gggactgtca cagggcagaa gcggcgtgca      540

gaacaggact cgactacagt agctgccttt gccagttcgt tagtctctgg tctgaactct      600

tcagcatcgg aaccagcaaa ggagccagcc aagaaatcaa ggaaacatgc tgcctcagat      660

gttgatctgg agatagagag ccttctgaac caacagtcca ctaaggaaca acagagcaag      720

aaggtcagtc aggagatcct agagctatta aatactacaa cagccaagga acaatccatt      780

gttgaaaaat ttcgctctcg aggtcgggcc caagtgcaag aattctgtga ctatggaacc      840

aaggaggagt gcatgaaagc cagtgatgct gatcgaccct gtcgcaagct gcacttcaga      900

cgaattatca ataaacacac tgatgagtct ttaggtgact gctctttcct taatacatgt      960

ttccacatgg atacctgcaa gtatgttcac tatgaaattg atgcttgcat ggattctgag     1020

gcccctggca gcaaagacca cacgccaagc caggagcttg ctcttacaca gagtgtcgga     1080

ggtgattcca gtgcagaccg actcttccca cctcagtgga tctgttgtga tatccgctac     1140

ctggacgtca gtatcttggg caagtttgca gttgtgatgg ctgacccacc ctgggatatt     1200

cacatggaac tgccctatgg gaccctgaca gatgatgaga tgcgcaggct caacataccc     1260

gtactacagg atgatggctt tctcttcctc tgggtcacag gcagggccat ggagttgggg     1320

agagaatgtc taaacctctg ggggtatgaa cgggtagatg aaattatttg ggtgaagaca     1380

aatcaactgc aacgcatcat tcggacaggc cgtacaggtc actggttgaa ccatgggaag     1440

gaacactgct tggttggtgt caaaggaaat ccccaaggct tcaaccaggg tctggattgt     1500

gatgtgatcg tagctgaggt tcgttccacc agtcataaac cagatgaaat ctatggcatg     1560

attgaaagac tatctcctgg cactcgcaag attgagttat ttggacgacc acacaatgtg     1620

caacccaact ggatcaccct tggaaaccaa ctggatggga tccacctact agacccagat     1680

gtggttgcac ggttcaagca aaggtaccca gatggtatca tctctaaacc taagaattta     1740

tag                                                                   1743


<210>  382
<211>  2208
<212>  DNA
<213>  Homo sapiens;

<400>  382
atggcggctg gcggagctgt cgctgcggcg cccgagtgcc ggcttctccc ctacgcgcta       60

cacaagtgga gctccttttc ctccacctac cttcccgaga acattttagt ggacaaacca      120

aatgaccaat cttcaagatg gtcttcagag agcaactatc ctccccagta cttgattcta      180

aagctcgaaa ggcctgctat agttcagaat atcacatttg gaaaatatga gaaaactcat      240

gtttgcaatt tgaagaaatt taaagtcttt ggtggaatga atgaagaaaa tatgacagag      300

ctgttgtcca gtggcttaaa gaatgattat aacaaagaaa cattcacctt gaagcataaa      360

attgatgaac agatgttccc ttgtcgattc attaaaatag ttccactctt gtcctgggga      420

cccagcttta actttagcat ctggtatgtt gaacttagtg gcattgatga tcctgatata      480

gtacaacctt gtctcaactg gtatagcaag taccgtgaac aggaagctat tcgcctttgc      540

ctaaaacact tcagacaaca caactataca gaagcttttg agtcactgca aaagaaaacc      600

aagattgcac tggaacatcc catgttaaca gatattcatg acaagctggt gttgaagggt      660

gattttgatg cttgcgaaga gttgattgaa aaggctgtaa atgatggctt gttcaatcag      720

tatatcagtc aacaggaata taagccacga tggagtcaaa tcattcccaa aagtaccaaa      780

ggtgatgggg aagataaccg tccaggaatg agaggaggcc atcagatggt tattgatgtt      840

caaacagaga ctgtttattt gtttggtggc tgggatggaa cacaagatct tgctgacttc      900

tgggcgtaca gtgtgaagga gaaccagtgg acatgtatct ctagagacac tgaaaaagag      960

aatggtccta gtgccagatc gtgtcataaa atgtgcattg atattcaacg gaggcaaatc     1020

tacacattgg ggcgttactt ggattcctct gtgaggaaca gcaaatctct gaaaagtgac     1080

ttctatcgtt atgacattga tacaaacaca tggatgttac taagtgagga tactgctgct     1140

gatggagggc cgaaattggt gtttgatcat cagatgtgta tggactcaga aaaacatatg     1200

atctacactt ttggtggtag aattttgact tgtaatggca gcgtagatga cagcagagcc     1260

agtgaaccac aattcagtgg cttgtttgct ttcaactgtc aatgtcaaac ctggaaactt     1320

cttcgagagg actcctgtaa tgctgggcct gaggacatcc agtctcgaat aggacactgc     1380

atgttattcc actcaaaaaa tcgttgctta tatgtatttg gtggccagcg atcaaagacc     1440

tatttgaatg atttctttag ttatgatgtg gactctgatc atgtagacat aatatcagat     1500

ggcaccaaga aagactctgg gatggttcca atgacaggat ttacacagag agcaactatt     1560

gatccagaac tgaatgaaat acacgtctta tctggactca gcaaagataa ggaaaagagg     1620

gaagaaaatg ttagaaattc attctggatt tatgacattg tgaggaatag ttggtcttgt     1680

gtctataaga atgatcaagc tgcaaaggat aatccaacta aaagtcttca ggaagaagaa     1740

ccatgtccaa ggtttgccca tcagcttgta tacgatgagc tacacaaggt tcattactta     1800

tttggtggga atccaggaaa atcttgctct ccaaagatga gattagatga cttctggtca     1860

ctgaagttgt gtagaccttc aaaagattat ttactgaggc attgcaagta cctcataaga     1920

aaacacaggt ttgaagaaaa ggcccaagtg gatcccctta gtgctctgaa atatttacaa     1980

aatgatcttt atataactgt ggatcattca gacccagaag agacaaaaga gtttcagctc     2040

ctggcatcag ctctattcaa atctggttca gattttacag ctctgggctt ttctgatgtg     2100

gatcacacct atgctcaaag aactcagctc tttgacacct tagtaaattt ctttcctgac     2160

agcatgactc ctcctaaagg caacctggta gacctcatca cactgtaa                  2208


<210>  383
<211>  1449
<212>  DNA
<213>  Homo sapiens;

<400>  383
atggcggagg ctgcaactcc cggaacaaca gccacaacat caggagcagg agcggcagcg       60

gcgacggcgg cagcagcctc ccccaccccg atccccacag tcaccgcccc gtccctgggg      120

gcgggcggag ggggcggcgg cagcgacggc agcggcggcg gctggactaa acaggtcacc      180

tgcaggtatt ttatgcatgg ggtttgtaag gaaggagaca actgtcgcta ctcgcatgac      240

ctctctgaca gtccgtatag tgtagtgtgc aagtattttc agcgagggta ctgtatttat      300

ggagaccgct gcagatatga acatagcaaa ccattgaaac aggaagaagc aactgctaca      360

gagctaacta caaagtcatc ccttgctgct tcctcaagtc tctcatcgat agttggacca      420

cttgttgaaa tgaatacagg cgaagctgag tcaagaaatt caaactttgc aactgtagga      480

gcaggttcag aggactgggt gaatgctatt gagtttgttc ctgggcaacc ctactgtggc      540

cgtactgcgc cttcctgcac tgaagcaccc ctgcagggct cagtgaccaa ggaagaatca      600

gagaaagagc aaaccgccgt ggagacaaag aagcagctgt gcccctatgc tgcagtggga      660

gagtgccgat acggggagaa ctgtgtgtat ctccacggag attcttgtga catgtgtggg      720

ctgcaggtcc tgcatccaat ggatgctgcc cagagatcgc agcatatcaa atcgtgcatt      780

gaggcccatg agaaggacat ggagctctca tttgccgtgc agcgcagcaa ggacatggtg      840

tgtgggatct gcatggaggt ggtctatgag aaagccaacc ccagtgagcg ccgcttcggg      900

atcctctcca actgcaacca cacctactgt ctcaagtgca ttcgcaagtg gaggagtgct      960

aagcaatttg agagcaagat cataaagtcc tgcccagaat gccggatcac atctaacttt     1020

gtcattccaa gtgagtactg ggtggaggag aaagaagaga agcagaaact cattctgaaa     1080

tacaaggagg caatgagcaa caaggcgtgc aggtattttg atgaaggacg tgggagctgc     1140

ccatttggag ggaactgttt ttacaagcat gcgtaccctg atggccgtag agaggagcca     1200

cagagacaga aagtgggaac atcaagcaga taccgggccc aacgaaggaa ccacttctgg     1260

gaactcattg aggaaagaga gaacagcaac ccctttgaca acgatgaaga agaggttgtc     1320

acctttgagc tgggcgagat gttgcttatg cttttggctg caggtgggga cgacgaacta     1380

acagactctg aagatgagtg ggacttgttt catgatgagc tggaagattt ttatgacttg     1440

gatctatag                                                             1449


<210>  384
<211>  1689
<212>  DNA
<213>  Homo sapiens;

<400>  384
atgcggctgc ggctccggct tctggcgctg ctgcttctgc tgctggcacc gcccgcgcgc       60

gccccgaagc cctcggcgca ggacgtgagc ctgggcgtgg actggctgac tcgctatggt      120

tacctgccgc caccccaccc tgcccaggcc cagctgcaga gccctgagaa gttgcgcgat      180

gccatcaaag tcatgcagag gttcgcgggg ctgccggaga ccggccgcat ggacccaggg      240

acagtggcca ccatgcgtaa gccccgctgc tccctgcctg acgtgctggg ggtggcgggg      300

ctggtcaggc ggcgtcgccg gtacgctctg agcggcagcg tgtggaagaa gcgaaccctg      360

acatggaggg tacgttcctt cccccagagc tcccagctga gccaggagac cgtgcgggtc      420

ctcatgagct atgccctgat ggcctggggc atggagtcag gcctcacatt tcatgaggtg      480

gattcccccc agggccagga gcccgacatc ctcatcgact ttgcccgcgc cttccaccag      540

gacagctacc ccttcgacgg gttggggggc accctagccc atgccttctt ccctggggag      600

caccccatct ccggggacac tcactttgac gatgaggaga cctggacttt tgggtcaaaa      660

gacggcgagg ggaccgacct gtttgccgtg gctgtccatg agtttggcca cgccctgggc      720

ctgggccact cctcagcccc caactccatt atgaggccct tctaccaggg tccggtgggc      780

gaccctgaca agtaccgcct gtctcaggat gaccgcgatg gcctgcagca actctatggg      840

aaggcgcccc aaaccccata tgacaagccc acaaggaaac ccctggctcc tccgccccag      900

cccccggcct cgcccacaca cagcccatcc ttccccatcc ctgatcgatg tgagggcaat      960

tttgacgcca tcgccaacat ccgaggggaa actttcttct tcaaaggccc ctggttctgg     1020

cgcctccagc cctccggaca gctggtgtcc ccgcgacccg cacggctgca ccgcttctgg     1080

gaggggctgc ccgcccaggt gagggtggtg caggccgcct atgctcggca ccgagacggc     1140

cgaatcctcc tctttagcgg gccccagttc tgggtgttcc aggaccggca gctggagggc     1200

ggggcgcggc cgctcacgga gctggggctg cccccgggag aggaggtgga cgccgtgttc     1260

tcgtggccac agaacgggaa gacctacctg gtccgcggcc ggcagtactg gcgctacgac     1320

gaggcggcgg cgcgcccgga ccccggctac cctcgcgacc tgagcctctg ggaaggcgcg     1380

cccccctccc ctgacgatgt caccgtcagc aacgcaggtg acacctactt cttcaagggc     1440

gcccactact ggcgcttccc caagaacagc atcaagaccg agccggacgc cccccagccc     1500

atggggccca actggctgga ctgccccgcc ccgagctctg gtccccgcgc ccccaggccc     1560

cccaaagcga cccccgtgtc cgaaacctgc gattgtcagt gcgagctcaa ccaggccgca     1620

ggacgttggc ctgctcccat cccgctgctc ctcttgcccc tgctggtggg gggtgtagcc     1680

tcccgctga                                                             1689


<210>  385
<211>  2820
<212>  DNA
<213>  Homo sapiens;

<400>  385
atggcggcgc agccaccccg cgggatacgc ctcagcgcgc tttgcccgaa gtttttacat       60

acaaattcta ctagtcacac ctggccattc agtgcagttg ctgaattaat agataatgct      120

tatgatcctg atgtgaacgc taaacaaata tggattgaca aaacagtgat aaatgaccat      180

atatgcttga cattcaccga caatgggaat ggtatgactt ctgataaatt acataaaatg      240

ctaagctttg gcttcagtga caaagtcacc atgaatggtc atgtcccagt tggattatat      300

gggaatggct tcaagtcggg ttctatgcgt ctgggtaaag acgcaatcgt ttttaccaaa      360

aatggagaaa gcatgagcgt gggccttttg tctcagacct acttggaagt cataaaagcg      420

gagcatgttg ttgttccaat agtggcattc aacaagcacc gacagatgat taatttagca      480

gaatcaaaag ccagccttgc tgcaattctg gaacattctc tgttttccac ggaacagaag      540

ttactggcag aacttgatgc tattataggc aagaagggga cgaggatcat catttggaat      600

cttagaagct acaaaaatgc aacagagttc gattttgaaa aggataaata tgatatcaga      660

attcccgagg atttagatga gataacaggg aagaaggggt acaagaagca ggaaaggatg      720

gaccagattg cccctgagag tgactattcc ctgagggctt attgcagtat attatatcta      780

aagccaagaa tgcagatcat cctacgtgga cagaaagtga agacacagct ggtttcgaag      840

agtcttgcct acatcgaacg tgatgtttat cgaccaaaat ttttatctaa aacagtgaga      900

attacctttg gattcaactg cagaaataaa gatcattatg ggataatgat gtatcacaga      960

aatagactca tcaaagctta tgaaaaagtt ggatgtcagt taagggcaaa caacatgggt     1020

gttggagtgg ttggaattat agagtgtaat ttccttaagc caactcataa taaacaagat     1080

ttcgactata ctaatgagta cagacttaca ataacagcac taggagaaaa gctgaatgat     1140

tactggaatg aaatgaaagt gaagaaaaat acagaatatc ctctaaattt gccagttgaa     1200

gatatacaga agcgtcctga tcagacatgg gttcagtgtg atgcctgtct aaagtggcgg     1260

aaattacctg atgggatgga tcaacttcct gaaaaatggt attgctccaa taaccctgac     1320

ccacagttca gaaattgtga ggttccagaa gaacctgaag atgaggattt ggtacatccc     1380

acttatgaaa aaacctacaa aaagaccaac aaggaaaaat tcaggatcag acaaccggaa     1440

atgatccctc ggattaatgc tgaactgttg tttcggccaa ctgctctttc aactccaagc     1500

ttttcttctc ctaaggaaag tgttccaaga agacatcttt cagaaggaac aaattcttat     1560

gcgacaagac ttctaaataa tcatcaagtt ccacctcagt ctgaacctga gagcaacagc     1620

ttgaaacgga gactttctac tcgttcctca attttgaatg caaagaatcg gagattgagt     1680

agtcagtttg aaaattcagt ttataaaggt gatgatgatg atgaagatgt catcatctta     1740

gaagaaaaca gtacccccaa acctgcagta gatcatgata ttgacatgaa atcagaacag     1800

agtcacgttg agcaaggtgg tgttcaggtt gagtttgtgg gtgacagtga accttgtggc     1860

cagactggtt caacaagcac ctcatcatcc cgatgcgacc agggaaatac tgcagctacc     1920

cagactgaag taccaagttt agttgttaaa aaagaagaaa ctgttgaaga cgagatagac     1980

gtaagaaatg atgcagtgat tctgccctcc tgtgtagaag ctgaagcaaa gatacatgaa     2040

acccaggaaa ccaccgataa atctgcagat gatgcaggct gccaattaca agaactgaga     2100

aaccagctac tccttgtcac tgaggaaaaa gagaattata aaagacagtg tcatatgttt     2160

actgatcaaa tcaaagtgtt acaacagagg atactagaaa tgaatgacaa gtatgttaag     2220

aaagaaactt gccatcagtc cactgaaacc gatgctgtat ttttacttga aagtattaat     2280

ggcaaatctg aaagtccaga ccatatggta tctcagtatc agcaagcttt ggaagaaata     2340

gaaaggctga aaaaacaatg tagtgctttg caacatgtaa aggctgaatg cagccagtgt     2400

tccaataatg agagtaaaag tgaaatggat gagatggctg tgcagcttga cgatgtgttt     2460

agacaactgg acaaatgcag tattgagagg gaccagtata aaagtgaggt tgaattgctg     2520

gaaatggaaa agtcacaaat ccgttcacag tgtgaagaac tcaaaactga agtagaacag     2580

ttaaaatcta caaatcaaca gacggcaaca gatgtttcaa catcaagtaa cattgaggag     2640

tctgtaaatc atatggatgg agaaagcctc aaactccgat ctcttcgagt taacgtagga     2700

caactgctgg ctatgattgt gcctgatctt gatcttcagc aagtgaatta cgatgttgat     2760

gtagttgatg agattttagg acaagttgtt gaacaaatga gtgaaatcag tagtacttaa     2820


<210>  386
<211>  1557
<212>  DNA
<213>  Homo sapiens;

<400>  386
atggcagaga atcacgccca gaataaagcc aagctcatct ctgagacccg gaggaggttc       60

gaagctgagt atgtgacaga taagtcagat aaatatgatg cacgtgatgt tgaaaggcta      120

caacaagatg ataactgggt tgaaagttac ttatcttgga gacataatat tgtagatgaa      180

acactgaaga tgctcgatga gagttttcag tggaggaaag aaatttctgt caatgacctt      240

aatgaatcct ccattcccag atggttattg gaaattggtg ttatttatct ccatggttat      300

gacaaagaag gtaacaaatt gttctggatc agggtgaagt atcatgtaaa agaccagaaa      360

accatattgg acaaaaagaa gctcatagca ttctggttgg aacgttatgc taagagggaa      420

aatgggaaac ctgtaacagt gatgtttgac ctgtcagaaa ctggaataaa tagcattgac      480

atggactttg tacgctttat catcaactgc tttaaggttt attaccctaa atacctctca      540

aaaatagtga tctttgatat gccttggtta atgaatgctg ctttcaaaat tgtgaaaacc      600

tggcttggtc cagaagcagt gagcttgttg aagtttacaa gcaaaaatga agtccaggac      660

tatgtcagtg tagaatacct gcctccccac atgggtggaa ctgatccttt caagtatagc      720

tatccaccac tagtagatga tgacttccag accccactgt gtgagaatgg gcctattacc      780

agtgaggatg aaacttcaag taaagaagac atagaaagtg atggcaaaga aacattggaa      840

acaatttcta atgaagaaca aacacctctt cttaaaaaga ttaacccaac cgaatctact      900

tccaaagcag aagaaaatga aaaagttgat tcaaaagtga aagctttcaa gaaaccattg      960

agtgtattta aaggcccctt actacacatc agcccagcag aagaactgta ctttggaagt     1020

acagaatccg gagagaagaa aaccttaata gtgttgacaa atgtaactaa aaatatagtg     1080

gcatttaagg tgagaacaac agctccagaa aaatacagag tcaagccaag caatagcagc     1140

tgtgacccgg gtgcatcagt ggatatagtt gtgtctcccc atgggggttt aacagtctct     1200

gcccaagacc gttttctgat aatggctgca gaaatggaac agtcatctgg cacaggccca     1260

gcagaattaa ctcagttttg gaaagaagtt cccagaaaca aagtgatgga acataggtta     1320

agatgccata ctgttgaaag cagtaaacca aacactctta cgttaaaaga caatgctttc     1380

aatatgtcag ataaaaccag tgaagatata tgtctacaac tcagtcgttt actagaaagc     1440

aataggaagc ttgaagacca agttcagcgt tgtatctggt tccagcagct gctgctttcc     1500

ttaacaatgc tcttgcttgc ttttgtcacc tctttcttct atttattgta cagttaa        1557


<210>  387
<211>  1191
<212>  DNA
<213>  Homo sapiens;

<400>  387
atggcgatga tcgaattggg gtttggaaga cagaattttc atccattaaa gaggaagagt       60

tcattgctgt tgaaactcat agctgttgtc tttgctgtgc ttctattttg tgaattttta      120

atctattact tagcgatctt tcagtgtaat tggcctgaag tgaaaaccac agcctctgat      180

ggtgaacaga ccacacgtga gcctgtgctc aaagccatgt ttttggctga cacccatttg      240

cttggggaat tcctaggcca ctggctggac aaattacgaa gggaatggca gatggagaga      300

gcgttccaga cagctctgtg gttgctgcag ccggaagtcg tcttcatcct gggggatatc      360

tttgatgaag ggaagtggag cacccctgag gcctgggcgg atgatgtgga gcggtttcag      420

aaaatgttca gacacccaag tcatgtacag ctgaaggtag ttgctggaaa ccatgacatt      480

ggcttccatt atgagatgaa cacatacaaa gtagaacgct ttgagaaagt gttcagctct      540

gaaagactgt tttcttggaa aggcattaac tttgtgatgg tcaacagcgt ggcgctgaac      600

ggggatggct gtggcatctg ctctgaaaca gaagcagagc tcattgaagt ttctcacaga      660

ctgaactgct cccgagaggc acgtggctcc agccggtgtg gacctgggcc tctgctgccc      720

acgtctgccc ctgtcctcct gcagcattat cctctgtatc ggagaagtga tgctaactgt      780

tctggggaag acgctgctcc tgcagaggaa agggacatcc catttaagga gaactatgac      840

gtgctttcac gggaggcatc acaaaagctg ctgtggtggc tccagccgcg cctggttctc      900

agtggccaca cgcacagcgc ctgcgaggtg caccacgggg gccgagtccc cgagctcagc      960

gtcccatctt tcagttggag gaacagaaac aaccccagtt tcatcatggg tagcatcacg     1020

cccacagact acaccctctc caagtgctac ctcccacgtg aggatgtggt tttgatcatc     1080

tactgtggag tggtgggctt ccttgtggtc ctcacactca ctcactttgg gcttctagcc     1140

tcaccttttc tttctggttt gaacttgctc ggaaagcgta agacaagatg a              1191


<210>  388
<211>  1056
<212>  DNA
<213>  Homo sapiens;

<400>  388
atggaaaggc ggatgcagct ggtaaagaag gataacgaga aagaaaggca caagctgttt       60

cagggctatg aaactgaaga gagagaggaa acagagctat ctgagaaaat taaactggag      120

tgccagccgg agctttccga gacatcccag actctgcctc ccaagccctt ctcatgtggg      180

cggagtggaa agggacataa aaggaaatcc ccatttggaa gtacagaaag aaagactcct      240

gttaaaaagc tggctcctga attttcaaaa gtcaaaacaa aaactcctaa gcactctcct      300

attaaagagg aaccctgtgg ttccttatct gaaactgttt gtaaacgtga attgaggagc      360

caagaaaccc cagaaaagcc ccggtcttca gtggacaccc caccaagact ctccactccc      420

caaaagggac ccagcaccca tcccaaggag aaagccttct caagtgagat agaagatttg      480

ccgtaccttt ccaccacaga aatgtatttg tgtcgttggc accagcctcc cccatcaccg      540

ttaccattac gggaatcctc tccaaagaag gaggagactg tagcaaggtg tctgatgcca      600

tcaagtgttg caggagaaac ttcagtcttg gctgttcctt cttggaggga ccactcagta      660

gagcctctaa gggacccaaa tccttcagac cttttggaga acctggatga cagtgtgttt      720

tcgaagcggc atgcaaaact ggagctggat gagaagagaa ggaaaagatg ggatattcag      780

aggatcaggg aacaaagaat tttacagcga ctgcagctca gaatgtataa aaagaaagga      840

attcaggaat ctgagcctga ggttacctca tttttccctg agccagatga tgttgaaagt      900

ttgatgatta cccccttctt gcctgttgta gcatttggac gaccattacc aaaattaact      960

ccacagaatt ttgagctacc ctggttggat gagcgtagcc gatgcagatt ggagatccag     1020

aagaagcaaa cacctcaccg gacgtgtagg aaatag                               1056


<210>  389
<211>  3597
<212>  DNA
<213>  Homo sapiens;

<400>  389
atggatgaag agactcggca cagccttgag tgcatccagg ccaatcagat ctttcccagg       60

aagcagctga tccgggagga tgagaatctt caggttcctt tccttgaact tcatggagag      120

agcacagagt ttgtgggccg tgccgaggat gccatcattg ccctttccaa ttacagactt      180

cacatcaagt tcaaggagtc tcttgttaat gttccattac agcttataga aagtgttgaa      240

tgccgagata tatttcagct tcatttgact tgcaaagact gcaaagttat caggtgtcag      300

ttttcaacct ttgagcagtg tcaagagtgg ctgaagagac tgaacaacgc aatccgacca      360

cctgctaaaa tagaagatct cttctcattt gcataccatg cttggtgcat ggaggtctat      420

gccagtgaaa aagagcaaca tggagacctg tgcagaccag gggagcatgt aacttcaagg      480

tttaaaaacg aggtggagag gatgggtttt gatatgaaca acgcctggag gatttccaac      540

atcaatgaga agtacaaatt atgtggtagc tatcctcaag agctcatagt gcctgcctgg      600

atcactgaca aagaactgga aagtgtatca agtttcaggt cctggaagcg catccctgcc      660

gtcatctaca ggcaccagag caatggagct gtcattgccc gctgtggaca gccagaggtt      720

agctggtggg gctggcgaaa tgcagatgat gagcatctgg tacagtcagt agccaaagct      780

tgtgcctctg actcccgatc gagtggcagc aagctgtcaa ctaggaacac ttctcgagac      840

tttcccaatg ggggagacct ttctgacgtg gagttcgatt cttctctgtc aaatgcttca      900

ggagcagaga gtttagccat ccaaccgcag aagcttttga tcttggatgc acgctcctat      960

gcagctgctg tggcaaaccg agccaaagga ggaggctgcg aatgcccaga gtattaccca     1020

aactgtgaag ttgtgtttat ggggatggca aacattcatt ctattcggag gagttttcag     1080

tctctgcggt tgctgtgcac tcagatgcca gatccgggaa attggctatc agctcttgaa     1140

agcacaaaat ggctccatca cttgtctgtg cttctgaaat cagcgcttct ggtagtgcat     1200

gctgtggatc aggatcagcg gccggtgcta gtacactgct cagatggctg ggaccgcacc     1260

ccccagattg tggcattggc taagctcttg ctggaccctt attaccgaac catagagggt     1320

ttccaggtcc tcgtggaaat ggagtggctg gattttggcc ataaatttgc tgaccggtgt     1380

ggtcatgggg agaactcgga tgatctgaat gaacgttgcc cagtgtttct gcagtggctt     1440

gactgtgttc atcagcttca gaggcaattt ccttgctctt ttgagttcaa tgaagcattc     1500

cttgtgaaac tggtgcagca tacctattcc tgcctgtttg gaacattcct gtgcaacaac     1560

gccaaggaga gaggggaaaa gcatactcag gaacggacat gttccgtgtg gtcacttctt     1620

cgggcaggca acaaggcttt caaaaaccta ctgtattcct ctcagtcaga agccgtgctg     1680

taccctgtgt gccatgtgcg taacctgatg ctgtggagtg cagtgtacct gccctgccca     1740

tccccaacca cccctgtgga cgacagctgt gcaccatacc cagccccagg caccagccct     1800

gatgatcccc ccctgagccg gctaccaaag actagatcat acgacaatct gaccacagcc     1860

tgtgacaaca cagtgcctct ggccagccgg cgctgcagcg accccagcct gaacgagaag     1920

tggcaggagc accggcgctc actagagctg agcagcctgg ctggccctgg agaggatccc     1980

ctttctgccg acagcctagg gaagcccacc agagtgccgg ggggtgccga gctttctgtt     2040

gcagccggag tagctgaggg gcagatggag aacatcttgc aggaggccac caaagaggag     2100

agtggagtag aggaacctgc ccacagggca ggcattgaga tacaggaggg taaagaggac     2160

cctctcttag aaaaggagag caggaggaag acacctgagg cctcagccat tggacttcac     2220

caagacccag aactgggtga tgctgctctg aggagccatc tggatatgag ctggcctctg     2280

ttctcacagg gcatttctga acagcagagt gggctcagtg ttctcctcag ttctctccag     2340

gtccccccca ggggagagga ttccctggag gtccctgtgg agcagtttcg aatagaagag     2400

attgcagagg gtagggagga agcagttctt ccaatcccag tagatgcaaa agttggctat     2460

ggtacctcac agtcatgttc tctgctacct tcccaagtcc cttttgagac cagaggacca     2520

aacgtggaca gttctacaga catgttagtg gaagataagg tgaagtcagt aagtgggccc     2580

caaggtcatc atagatcttg ccttgtaaat agtggcaagg acaggcttcc tcagaccatg     2640

gaacccagcc cttcagagac aagcctggtc gagaggcccc aagtggggtc tgtggtgcat     2700

aggacttccc ttggcagcac tctcagcctg acacgttccc cttgtgcctt gcctttagcc     2760

gaatgtaaag aggggcttgt gtgcaatggt gccccagaga ctgaaaacag ggcctcagag     2820

cagcccccag gtcttagcac cctccagatg taccccacac ccaatgggca ttgcgccaat     2880

ggggaggctg gtaggagcaa ggactcactg agccgtcagc tgtctgctat gagctgcagc     2940

tctgcccact tacactcaag gaacttgcac cacaagtggc tgcatagcca ctcaggaagg     3000

ccatctgcaa ccagcagccc cgaccagcct tcccgcagcc acctggacga tgatggcatg     3060

tcagtgtaca cagacacgat ccaacagcgc ctgcgtcaga ttgagtcagg ccaccagcag     3120

gaagtagaaa ctttgaagaa acaagtccag gagctgaaga gtcgcctgga gagccagtac     3180

ctgaccagct ccctacactt taatggagac tttggggatg aggtgacttc aatccccgac     3240

tcggaaagca atctggatca gaactgtttg tctcgctgca gcacagagat tttctctgaa     3300

gccagctggg agcaggtgga taaacaggac acagagatga cccgttggct tcctgaccac     3360

ctggccgccc actgctatgc gtgcgacagt gccttctggc ttgccagcag gaagcaccac     3420

tgcaggaatt gtgggaacgt attctgctcc agttgttgta accagaaggt tccagttccc     3480

agccagcagc tctttgaacc cagtcgagta tgcaagtctt gctatagcag cctacatccc     3540

acaagctcca gcattgacct tgaactggat aagcccattg ctgccacttc caactga        3597


<210>  390
<211>  1989
<212>  DNA
<213>  Homo sapiens;

<400>  390
atggttgttt ccgaagtgga catcgcaaaa gctgatccag ctgctgcatc ccaccctcta       60

ttactgaatg gagatgctac tgtggcccag aaaaatccag gctcggtggc tgagaacaac      120

ctgtgcagcc agtatgagga gaaggtgcgc ccctgcatcg acctcattga ctccctgcgg      180

gctctaggtg tggagcagga cctggccctg ccagccatcg ccgtcatcgg ggaccagagc      240

tcgggcaaga gctccgtgtt ggaggcactg tcaggagttg cccttcccag aggcagcggg      300

atcgtgacca gatgcccgct ggtgctgaaa ctgaagaaac ttgtgaacga agataagtgg      360

agaggcaagg tcagttacca ggactacgag attgagattt cggatgcttc agaggtagaa      420

aaggaaatta ataaagccca gaatgccatc gccggggaag gaatgggaat cagtcatgag      480

ctaatcaccc tggagatcag ctcccgagat gtcccggatc tgactctaat agaccttcct      540

ggcataacca gagtggctgt gggcaatcag cctgctgaca ttgggtataa gatcaagaca      600

ctcatcaaga agtacatcca gaggcaggag acaatcagcc tggtggtggt ccccagtaat      660

gtggacatcg ccaccacaga ggctctcagc atggcccagg aggtggaccc cgagggagac      720

aggaccatcg gaatcttgac gaagcctgat ctggtggaca aaggaactga agacaaggtt      780

gtggacgtgg tgcggaacct cgtgttccac ctgaagaagg gttacatgat tgtcaagtgc      840

cggggccagc aggagatcca ggaccagctg agcctgtccg aagccctgca gagagagaag      900

atcttctttg agaaccaccc atatttcagg gatctgctgg aggaaggaaa ggccacggtt      960

ccctgcctgg cagaaaaact taccagcgag ctcatcacac atatctgtaa atctctgccc     1020

ctgttagaaa atcaaatcaa ggagactcac cagagaataa cagaggagct acaaaagtat     1080

ggtgtcgaca taccggaaga cgaaaatgaa aaaatgttct tcctgataga taaagttaat     1140

gcctttaatc aggacatcac tgctctcatg caaggagagg aaactgtagg ggaggaagac     1200

attcggctgt ttaccagact ccgacacgag ttccacaaat ggagtacaat aattgaaaac     1260

aattttcaag aaggccataa aattttgagt agaaaaatcc agaaatttga aaatcagtat     1320

cgtggtagag agctgccagg ctttgtgaat tacaggacat ttgagacaat cgtgaaacag     1380

caaatcaagg cactggaaga gccggctgtg gatatgctac acaccgtgac ggatatggtc     1440

cggcttgctt tcacagatgt ttcgataaaa aattttgaag agttttttaa cctccacaga     1500

accgccaagt ccaaaattga agacattaga gcagaacaag agagagaagg tgagaagctg     1560

atccgcctcc acttccagat ggaacagatt gtctactgcc aggaccaggt atacaggggt     1620

gcattgcaga aggtcagaga gaaggagctg gaagaagaaa agaagaagaa atcctgggat     1680

tttggggctt tccagtccag ctcggcaaca gactcttcca tggaggagat ctttcagcac     1740

ctgatggcct atcaccagga ggccagcaag cgcatctcca gccacatccc tttgatcatc     1800

cagttcttca tgctccagac gtacggccag cagcttcaga aggccatgct gcagctcctg     1860

caggacaagg acacctacag ctggctcctg aaggagcgga gcgacaccag cgacaagcgg     1920

aagttcctga aggagcggct tgcacggctg acgcaggctc ggcgccggct tgcccagttc     1980

cccggttaa                                                             1989


<210>  391
<211>  687
<212>  DNA
<213>  Homo sapiens;

<400>  391
atggagcggg tgaagatgat caacgtgcag cgtctgctgg aggctgccga gtttttggag       60

cgccgggagc gagagtgtga acatggctac gcctcttcat tcccgtccat gccgagcccc      120

cgactgcagc attcaaagcc cccacggagg ttgagccggg cacagaaaca cagcagcggg      180

agcagcaaca ccagcactgc caacagatct acacacaatg agctggaaaa gaatcgacga      240

gctcatctgc gcctttgttt agaacgctta aaagttctga ttccactagg accagactgc      300

acccggcaca caacacttgg tttgctcaac aaagccaaag cacacatcaa gaaacttgaa      360

gaagctgaaa gaaaaagcca gcaccagctc gagaatttgg aacgagaaca gagattttta      420

aagtggcgac tggaacagct gcagggtcct caggagatgg aacgaatacg aatggacagc      480

attggatcaa ctatttcttc agatcgttct gattcagagc gagaggagat tgaagtggat      540

gttgaaagca cagagttctc ccatggagaa gtggacaata taagtaccac cagcatcagt      600

gacattgatg accacagcag cctgccgagt attgggagtg acgagggtta ctccagtgcc      660

agtgtcaaac tttcattcac ttcatag                                          687


<210>  392
<211>  1365
<212>  DNA
<213>  Homo sapiens;

<400>  392
ctggattttt ttcgggtagt ggaaaaccag cagcctcccg cgacgatgcc cctcaacgtt       60

agcttcacca acaggaacta tgacctcgac tacgactcgg tgcagccgta tttctactgc      120

gacgaggagg agaacttcta ccagcagcag cagcagagcg agctgcagcc cccggcgccc      180

agcgaggata tctggaagaa attcgagctg ctgcccaccc cgcccctgtc ccctagccgc      240

cgctccgggc tctgctcgcc ctcctacgtt gcggtcacac ccttctccct tcggggagac      300

aacgacggcg gtggcgggag cttctccacg gccgaccagc tggagatggt gaccgagctg      360

ctgggaggag acatggtgaa ccagagtttc atctgcgacc cggacgacga gaccttcatc      420

aaaaacatca tcatccagga ctgtatgtgg agcggcttct cggccgccgc caagctcgtc      480

tcagagaagc tggcctccta ccaggctgcg cgcaaagaca gcggcagccc gaaccccgcc      540

cgcggccaca gcgtctgctc cacctccagc ttgtacctgc aggatctgag cgccgccgcc      600

tcagagtgca tcgacccctc ggtggtcttc ccctaccctc tcaacgacag cagctcgccc      660

aagtcctgcg cctcgcaaga ctccagcgcc ttctctccgt cctcggattc tctgctctcc      720

tcgacggagt cctccccgca gggcagcccc gagcccctgg tgctccatga ggagacaccg      780

cccaccacca gcagcgactc tgaggaggaa caagaagatg aggaagaaat cgatgttgtt      840

tctgtggaaa agaggcaggc tcctggcaaa aggtcagagt ctggatcacc ttctgctgga      900

ggccacagca aacctcctca cagcccactg gtcctcaaga ggtgccacgt ctccacacat      960

cagcacaact acgcagcgcc tccctccact cggaaggact atcctgctgc caagagggtc     1020

aagttggaca gtgtcagagt cctgagacag atcagcaaca accgaaaatg caccagcccc     1080

aggtcctcgg acaccgagga gaatgtcaag aggcgaacac acaacgtctt ggagcgccag     1140

aggaggaacg agctaaaacg gagctttttt gccctgcgtg accagatccc ggagttggaa     1200

aacaatgaaa aggcccccaa ggtagttatc cttaaaaaag ccacagcata catcctgtcc     1260

gtccaagcag aggagcaaaa gctcatttct gaagaggact tgttgcggaa acgacgagaa     1320

cagttgaaac acaaacttga acagctacgg aactcttgtg cgtaa                     1365


<210>  393
<211>  2691
<212>  DNA
<213>  Homo sapiens;

<400>  393
atggcggccc gggcggtgct ggacgagttc actgcgccag ctgagaaggc ggagctgctg       60

gagcagagcc gcggccgtat cgagggcctg tttggcgtga gcctagccgt gctcggcgcg      120

ctaggggctg aggagccgct gcccgcgcgc atctggctgc agctctgcgg ggcgcaggag      180

gcggtgcaca gcgccaagga atatattaaa ggaatctgtg aacctgaact agaagaaaga      240

gaatgttacc ccaaggacat gcactgcatt tttgttgggg cagagagcct gtttctgaaa      300

agcttgattc aggatacttg tgctgacctc tgcattctgg acattggcct tcttggcatc      360

agaggaagtg ctgaggctgt ggtcatggct aggagtcaca ttcaacaatt tgtaaagctc      420

tttgaaaata aagagaacct acccagtagt cagaaagaat cagaggtgaa aagggaattc      480

aaacaatttg ttgaagccca tgcagacaat tacacaatgg atttgttgat tttgcccact      540

tccttgaaaa aagaactttt gacactcaca caaggtgagg agaatctctt tgaaacagga      600

gatgatgagg ttattgaaat gagagattct caacaaacag agtttacaca gaatgctgcc      660

acagggctga atatttctag agatgaaact gttttgcagg aagaggcaag aaataaagct      720

gggactcctg tttctgagct tacaaaacaa atggacacag tcctttctag ctcaccagat      780

gtgctttttg atccaataaa tggtctaacc ccagatgaag aggcactttc caatgagaga      840

atttgtcaga aaaggagatt ttctgattct gaagaaaggc atacgaagaa gcagttttct      900

ttggaaaatg ttcaggaggg ggagatttta cacgatgcta agacattggc tggaaatgta      960

atagctgacc tatctgattc ttctgctgat tctgaaaatt taagtccaga tataaaagaa     1020

actactgagg aaatggaata caacatcctc gtaaactttt ttaaaaccat gggctactcc     1080

caagaaattg ttgaaaaggt cattaaggtg tatggaccat ctactgaacc attattgctc     1140

ttagaggaaa ttgaaaaaga aaataaaaga ttccaagaag acagagaatt ttcagctggt     1200

acagtgtatc cagagaccaa caaaaccaaa aataaaggtg tttatagcag cacaaatgag     1260

cttacaactg attccactcc aaagaaaaca caggctcaca cacagcaaaa tatggtagaa     1320

aaattttctc agttaccatt caaagtggaa gctaaaccat gtacctcaaa ttgtagaatt     1380

aatactttca gaacagtgcc aatagaacag aaacatgaag tctggggttc aaaccagaac     1440

tacatttgta acacagaccc tgaaactgat ggcctttcac cttctgttgc ctctccaagt     1500

cccaaagaag tcaattttgt ttcaagggga gcttcaagtc accagcccag agttccactt     1560

tttcctgaaa atggtttaca ccagcagcca gaacccttgc ttccaaataa tatgaaatct     1620

gcctgtgaaa aacgtttagg atgttgtagt tctcctcatt ctaagccaaa ttgctcaacc     1680

ctttctccac caatgccact gccccagctg ttaccttcgg ttactgatgc aaggtcggca     1740

ggaccttctg atcatattga ttcctcagtt actggggttc aaaggtttcg agatactcta     1800

aaaataccct acaagctgga attaaaaaat gaaccaggga gaacggattt gaaacacatt     1860

gttatagatg ggagcaatgt tgcaattacc catggtctga aaaagttctt ttcttgtcgt     1920

ggaattgcaa ttgcagttga atatttttgg aagcttggca acagaaacat cactgtattt     1980

gtccctcagt ggagaacaag gcgtgatcct aatgtcacag aacagcactt cttaacccag     2040

ctccaggagc tcggaatatt atctttaact cctgcccgga tggtctttgg agaaagaatt     2100

gcttctcatg atgacaggtt tctactacac ttagcggaca aaactggtgg cataattgtg     2160

acaaatgata atttcagaga atttgtgaat gagtcagtct cttggagaga aattattaca     2220

aaaaggctgc tgcagtacac gttcgtgggg gacatattta tggttcccga tgatcctctg     2280

ggaagaagtg gacctcgatt agaggagttt cttcagaagg aagtctgtct tagagatatg     2340

cagcccctac tcagtgccct gccaaatgtg ggcatgtttg accccagctt cagagtccct     2400

ggcacccagg cagccagcac cagccaccag cctccgaccc ggattcaggg agccccttca     2460

agccactggc tccctcagca gccccacttc ccactgctgc cagccctccc cagtctccag     2520

cagaacctgc ccatgccagc tcagagatct tctgcagaaa ccaacgagct gagggaagcc     2580

cttctgaaga tcttccctga ctcagagcaa agactgaaaa tagaccagat cttggtggcc     2640

cacccataca tgaaagatct aaatgcgctt tctgccatgg tgttggattg a              2691


<210>  394
<211>  1464
<212>  DNA
<213>  Homo sapiens;

<400>  394
atggctgcgg ccttacccag gaccctgggg gagttgcagc tgtatagaat attacaaaaa       60

gccaatctac tttcttattt tgatgccttt atccaacaag gtggtgatga tgtccagcaa      120

ctctgtgaag caggagaaga ggagtttttg gaaatcatgg cactcgtggg catggctagc      180

aagccccttc atgttagaag gctgcagaag gctttgagag actgggtcac aaaccctggg      240

cttttcaatc agccactgac ttcccttcct gtcagtagca tacccatcta taaattacca      300

gagggatcac caacatggct gggaatatcc tgcagtagtt atgaaaggag tagcaatgcc      360

cgggaacctc atttaaaaat ccccaaatgt gctgccacca cctgtgtgca gagcttggga      420

caggggaagt cagatgtggt tgggagccta gcactgcaga gtgttggtga gtccagactc      480

tggcaaggcc accatgccac tgagagcgag cacagcctct ccccagcaga cctgggctcc      540

cccgcgtccc caaaggagag cagtgaggcg ctggatgctg ctgctgcgct ctctgtggct      600

gagtgtgtgg agcggatggc ccccacactg ccaaaaagtg acttgaatga agtgaaagag      660

ctgctaaaaa ccaacaagaa gttggccaaa atgattggtc acatctttga gatgaacgat      720

gatgatccac acaaagagga ggaaattcgg aaatacagtg caatatatgg cagatttgac      780

tcaaagagga aggatgggaa acatctcaca cttcatgagc tcactgttaa tgaagcggct      840

gctcaactct gtgtgaagga taatgccctg ctgacaagaa gagatgagct ttttgccttg      900

gctcgacaga tttctcgaga agtcacctat aaatatactt acagaaccac caagtcaaaa      960

tgtggagaaa gagatgaatt atccccaaag agaattaaag tggaggatgg gtttccagat     1020

ttccaggatt ctgtgcaaac actcttccag caggctagag ctaagagtga agaacttgca     1080

gctcttagtt cacagcagcc tgaaaaggtg atggcaaagc agatggagtt cctttgcaac     1140

caagctggct atgagagact gcagcatgcc gagaggaggt tgtctgcagg gctttacagg     1200

cagagctcag aagagcacag tcctaacggc ttgacttccg ataactcaga tggacaagga     1260

gaaagacctt tgaatctccg aatgcctaat ttacagaaca gacaacccca tcattttgtg     1320

gtggatgggg agctgagcag actttacccc agtgaggcaa agtcccactc atcagagagc     1380

cttgggattt taaaagacta ccctcattca gcttttacct tagaaaagaa agtcatcaaa     1440

acagagcctg aagattcaag atag                                            1464


<210>  395
<211>  648
<212>  DNA
<213>  Homo sapiens;

<400>  395
atgcccggcg aagccacaga aaccgtccct gctacagagc aggagttgcc gcagccccag       60

gctgagacag ggtctggaac agaatctgac agtgatgaat cagtaccaga gcttgaagaa      120

caggattcca cccaggcaac cacacaacaa gcccagctgg cggcagcagc tgaaattgat      180

gaagaaccag tcagtaaagc aaaacagagt cggagtgaaa agaaggcacg gaaggctatg      240

tccaaactgg gtcttcggca ggttacagga gttactagag tcactatccg gaaatctaag      300

aatatcctct ttgtcatcac aaaaccagat gtctacaaga gccctgcttc agatacttac      360

atagtttttg gggaagccaa gatcgaagat ttatcccagc aagcacaact agcagctgct      420

gagaaattca aagttcaagg tgaagctgtc tcaaacattc aagaaaacac acagactcca      480

actgtacaag aggagagtga agaggaagag gtcgatgaaa caggtgtaga agttaaggac      540

attgaattgg tcatgtcaca agcaaatgtg tcgagagcaa aggcagtccg agccctgaag      600

aacaacagta atgatattgt aaatgcgatt atggaattaa caatgtaa                   648


<210>  396
<211>  471
<212>  DNA
<213>  Homo sapiens;

<400>  396
atgtcgggtg gcctcctgaa ggcgctgcgc agcgactcct acgtggagct gagccagtac       60

cgggaccagc acttccgggg tgacaatgaa gaacaagaaa aattactgaa gaaaagctgt      120

acgttatatg ttggaaatct ttctttttac acaactgaag aacaaatcta tgaactcttc      180

agcaaaagtg gtgacataaa gaaaatcatt atgggtctgg ataaaatgaa gaaaacagca      240

tgtggattct gttttgtgga atattactca cgcgcagatg cggaaaacgc catgcggtac      300

ataaatggga cgcgtctgga tgaccgaatc attcgcacag actgggacgc aggctttaag      360

gagggcaggc aatacggccg tgggcgatct gggggccagg ttcgggatga gtatcggcag      420

gactacgatg ctgggagagg aggctatgga aaactggcac agaaccagtg a               471


<210>  397
<211>  4326
<212>  DNA
<213>  Homo sapiens;

<400>  397
atgagtggcc tcggggacag ttcatccgac cctgctaacc cagactcaca taagaggaaa       60

ggatcgccat gtgacacact ggcatcaagc acggaaaaga ggcgcaggga gcaagaaaat      120

aaatatttag aagaactagc tgagttactg tctgccaaca ttagtgacat tgacagcttg      180

agtgtaaaac cagacaaatg caagattttg aagaaaacag tcgatcagat acagctaatg      240

aagagaatgg aacaagagaa atcaacaact gatgacgatg tacagaaatc agacatctca      300

tcaagtagtc aaggagtgat agaaaaggaa tccttgggac ctcttctttt ggaggctttg      360

gatggatttt tctttgttgt gaactgtgaa gggagaattg tatttgtgtc agagaatgta      420

accagctact taggttacaa tcaggaggaa ttaatgaata cgagcgtcta cagcatactg      480

cacgtggggg atcatgcaga atttgtgaag aatctgctac caaaatcact agtaaatgga      540

gttccttggc ctcaagaggc aacacgacga aatagccata cctttaactg caggatgcta      600

attcaccctc cagatgagcc agggaccgag aaccaagaag cttgccagcg ttatgaagta      660

atgcagtgtt tcactgtgtc acagccaaaa tcaattcaag aggatggaga agatttccag      720

tcatgtctga tttgtattgc acggcgatta cctcggcctc cagctattac gggtgtagaa      780

tcctttatga ccaagcaaga tactacaggt aaaatcatct ctattgatac tagttccctg      840

agagctgctg gcagaactgg ttgggaagat ttagtgagga agtgcattta tgcttttttc      900

caacctcagg gcagagaacc atcttatgcc agacagctgt tccaagaagt gatgactcgt      960

ggcactgcct ccagcccctc ctatagattc atattgaatg atgggacaat gcttagcgcc     1020

cacaccaagt gtaaactttg ctaccctcaa agtccagaca tgcaaccttt catcatggga     1080

attcatatca tcgacaggga gcacagtggg ctttctcctc aagatgacac taattctgga     1140

atgtcaattc cccgagtaaa tccctcggtc aatcctagta tctctccagc tcatggtgtg     1200

gctcgttcat ccacattgcc accatccaac agcaacatgg tatccaccag aataaaccgc     1260

cagcagagct cagaccttca tagcagcagt catagtaatt ctagcaacag ccaaggaagt     1320

ttcggatgct cacccggaag tcagattgta gccaatgttg ccttaaacca aggacaggcc     1380

agttcacaga gcagtaatcc ctctttaaac ctcaataatt ctcctatgga aggtacagga     1440

atatccctag cacagttcat gtctccaagg agacaggtta cttctggatt ggcaacaagg     1500

cccaggatgc caaacaattc ctttcctcct aatatttcga cattaagctc tcccgttggc     1560

atgacaagta gtgcctgtaa taataataac cgatcttatt caaacatccc agtaacatct     1620

ttacagggta tgaatgaagg acccaataac tccgttggct tctctgccag ttctccagtc     1680

ctcaggcaga tgagctcaca gaattcacct agcagattaa atatacaacc agcaaaagct     1740

gagtccaaag ataacaaaga gattgcctca attttaaatg aaatgattca atctgacaac     1800

agctctagtg atggcaaacc tctggattca gggcttctgc ataacaatga cagactttca     1860

gatggagaca gtaaatactc tcaaaccagt cacaaactag tgcagctttt gacaacaact     1920

gccgaacagc agttacggca tgctgatata gacacaagct gcaaagatgt cctgtcttgc     1980

acaggcactt ccaactctgc ctctgctaac tcttcaggag gttcttgtcc ctcttctcat     2040

agctcattga cagaacggca taaaattcta caccggctct tacaggaggg tagcccctca     2100

gatatcacca ctttgtctgt cgagcctgat aaaaaggaca gtgcatctac ttctgtgtca     2160

gtgactggac aggtacaagg aaactccagt ataaaactag aactggatgc ttcaaagaaa     2220

aaagaatcaa aagaccatca gctcctacgc tatcttttag ataaagatga gaaagattta     2280

agatcaactc caaacctgag cctggatgat gtaaaggtga aagtggaaaa gaaagaacag     2340

atggatccat gtaatacaaa cccaacccca atgaccaaac ccactcctga ggaaataaaa     2400

ctggaggccc agagccagtt tacagctgac cttgaccagt ttgatcagtt actgcccacg     2460

ctggagaagg cagcacagtt gccaggctta tgtgagacag acaggatgga tggtgcggtc     2520

accagtgtaa ccatcaaatc ggagatcctg ccagcttcac ttcagtccgc cactgccaga     2580

cccacttcca ggctaaatag attacctgag ctggaattgg aagcaattga taaccaattt     2640

ggacaaccag gaacaggcga tcagattcca tggacaaata atacagtgac agctataaat     2700

cagagtaaat cagaagacca gtgtattagc tcacaattag atgagcttct ctgtccaccc     2760

acaacagtag aagggagaaa tgatgagaag gctcttcttg aacagctggt atccttcctt     2820

agtggcaaag atgaaactga gctagctgaa ctagacagag ctctgggaat tgacaaactt     2880

gttcaggggg gtggattaga tgtattatca gagagatttc caccacaaca agcaacgcca     2940

cctttgatca tggaagaaag acccaacctt tattcccagc cttactcttc tccttctcct     3000

actgccaatc tccctagccc tttccaaggc atggtcaggc aaaaaccttc actggggacg     3060

atgcctgttc aagtaacacc tccccgaggt gctttttcac ctggcatggg catgcagccc     3120

aggcaaactc taaacagacc tccggctgca cctaaccagc ttcgacttca actacagcag     3180

cgattacagg gacaacagca gttgatacac caaaatcggc aagctatctt aaaccagttt     3240

gcagcaactg ctcctgttgg catcaatatg agatcaggca tgcaacagca aattacacct     3300

cagccacccc tgaatgctca aatgttggca caacgtcagc gggaactgta cagtcaacag     3360

caccgacaga ggcagctaat acagcagcaa agagccatgc ttatgaggca gcaaagcttt     3420

gggaacaacc tccctccctc atctggacta ccagttcaaa tggggaaccc ccgtcttcct     3480

cagggtgctc cacagcaatt cccctatcca ccaaactatg gtacaaatcc aggaacccca     3540

cctgcttcta ccagcccgtt ttcacaacta gcagcaaatc ctgaagcatc cttggccaac     3600

cgcaacagca tggtgagcag aggcatgaca ggaaacatag gaggacagtt tggcactgga     3660

atcaatcctc agatgcagca gaatgtcttc cagtatccag gagcaggaat ggttccccaa     3720

ggtgaggcca actttgctcc atctctaagc cctgggagct ccatggtgcc gatgccaatc     3780

cctcctcctc agagttctct tctccagcaa actccacctg cctccgggta tcagtcacca     3840

gacatgaagg cctggcagca aggagcgata ggaaacaaca atgtgttcag tcaagctgtc     3900

cagaaccagc ccacgcctgc acagccagga gtatacaaca acatgagcat caccgtttcc     3960

atggcaggtg gaaatacgaa tgttcagaac atgaacccaa tgatggccca gatgcagatg     4020

agctctttgc agatgccagg aatgaacact gtgtgccctg agcagataaa tgatcccgca     4080

ctgagacaca caggcctcta ctgcaaccag ctctcatcca ctgaccttct caaaacagaa     4140

gcagatggaa cccagcaggt gcaacaggtt caggtgtttg ctgacgtcca gtgtacagtg     4200

aatctggtag gcggggaccc ttacctgaac cagcctggtc cactgggaac tcaaaagccc     4260

acgtcaggac cacagacccc ccaggcccag cagaagagcc tccttcagca gctactgact     4320

gaataa                                                                4326


<210>  398
<211>  1845
<212>  DNA
<213>  Homo sapiens;

<400>  398
atgaatacct tccaagacca gagtggcagc tccagtaata gagaacccct tttgaggtgt       60

agtgatgcac ggagggactt ggagcttgct attggtggag ttctccgggc tgaacagcaa      120

attaaagata acttgcgaga ggtcaaagct cagattcaca gttgcataag ccgtcacctg      180

gaatgtctta gaagccgtga ggtatggctg tatgaacagg tggaccttat ttatcagctt      240

aaagaggaga cacttcaaca gcaggctcag cagctctact cgttattggg ccagttcaat      300

tgtcttactc atcaactgga gtgtacccaa aacaaagatc tagccaatca agtctctgtg      360

tgcctggaga gactgggcag tttgaccctt aagcctgaag attcaactgt cctgctcttt      420

gaagctgaca caattactct gcgccagacc atcaccacat ttgggtctct caaaaccatt      480

caaattcctg agcacttgat ggctcatgct agttcagcaa atattgggcc cttcctggag      540

aagagaggct gtatctccat gccagagcag aagtcagcat ccggtattgt agctgtccct      600

ttcagcgaat ggctccttgg aagcaaacct gccagtggtt atcaagctcc ttacataccc      660

agcaccgacc cccaggactg gcttacccaa aagcagacct tggagaacag tcagacttct      720

tccagagcct gcaatttctt caataatgtc gggggaaacc taaagggctt agaaaactgg      780

ctcctcaaga gtgaaaaatc aagttatcaa aagtgtaaca gccattccac tactagttct      840

ttctccattg aaatggaaaa ggttggagat caagagcttc ctgatcaaga tgagatggac      900

ctatcagatt ggctagtgac tccccaggaa tcccataagc tgcggaagcc tgagaatggc      960

agtcgtgaaa ccagtgagaa gtttaagctc ttattccagt cctataatgt gaatgattgg     1020

cttgtcaaga ctgactcctg taccaactgt cagggaaacc agcccaaagg tgtggagatt     1080

gaaaacctgg gcaatctgaa gtgcctgaat gaccacttgg aggccaagaa accattgtcc     1140

acccccagca tggttacaga ggattggctt gtccagaacc atcaggaccc atgtaaggta     1200

gaggaggtgt gcagagccaa tgagccctgc acaagctttg cagagtgtgt gtgtgatgag     1260

aattgtgaga aggaggctct gtataagtgg cttctgaaga aagaaggaaa ggataaaaat     1320

gggatgcctg tggaacccaa acctgagcct gagaagcata aagattccct gaatatgtgg     1380

ctctgtccta gaaaagaagt aatagaacaa actaaagcac caaaggcaat gactccttct     1440

agaattgctg attccttcca agtcataaag aacagcccct tgtcggagtg gcttatcagg     1500

cccccataca aagaaggaag tcccaaggaa gtgcctggta ctgaagacag agctggcaaa     1560

cagaagttta aaagccccat gaatacttcc tggtgttcct ttaacacagc tgactgggtc     1620

ctgccaggaa agaagatggg caacctcagc cagttatctt ctggagaaga caagtggctg     1680

cttcgaaaga aggcccagga agtattactt aattcacctc tacaggagga acataacttc     1740

cccccagacc attatggcct ccctgcagtt tgtgatctct ttgcctgtat gcagcttaaa     1800

gttgataaag agaagtggtt atatcgaact cctctacaga tgtga                     1845


<210>  399
<211>  1008
<212>  DNA
<213>  Homo sapiens;

<400>  399
atggaggact ccggaaagac tttcagctcc gaggaggaag aagctaacta ttggaaagat       60

ctggcgatga cctacaaaca gagggcagaa aatacgcaag aggaactccg agaattccag      120

gagggaagcc gagaatatga agctgaattg gagacgcagc tgcaacaaat tgaaaccagg      180

aacagagacc tcctgtccga aaataaccgc cttcgcatgg agctggaaac catcaaggag      240

aagtttgaag tgcagcactc tgaaggctac cggcagatct cagccttgga ggatgacctc      300

gcgcagacca aagccattaa agaccaattg cagaaataca tcagagagct ggagcaagca      360

aatgacgacc tggaaagagc caagcgcgcc acgatcatgt ctctcgaaga ctttgagcag      420

cgcttgaatc aggccatcga aagaaatgcc ttcctggaaa gtgaacttga tgaaaaagag      480

aatctcctgg aatctgttca gagactgaag gatgaagcca gagatttgcg gcaggaactg      540

gccgtgcagc agaagcagga gaaacccagg acccccatgc ccagctcagt ggaagctgag      600

aggacagaca cagctgtgca ggccacgggc tccgtgccgt ccacgcccat tgctcaccga      660

ggacccagct caagtttaaa cacacctggg agcttcagac gtggcctgga cgactccacc      720

ggggggaccc ccctcacacc tgcggcccgg atatcagccc tcaacattgt gggagaccta      780

ctgcggaaag tcggggcact ggagtccaaa ctcgcttcct gccggaacct cgtgtacgat      840

cagtccccaa accgaacagg tggcccagcc tctgggcgga gcagcaagaa cagagatggc      900

ggggagagac ggccaagcag caccagcgtg cctttgggtg ataaggggtt ggacacgagt      960

tgccgctggt tgtccaaatc aacaaccagg tcgtccagct cctgctga                  1008


<210>  400
<211>  1038
<212>  DNA
<213>  Homo sapiens;

<400>  400
atggatggtg aagatatacc agatttttca agtttaaagg aggaaactgc ttattggaag       60

gaactttcct tgaagtataa gcaaagcttc caggaagctc gggatgagct agttgaattc      120

caggaaggaa gcagagaatt agaagcagag ttggaggcac aattagtaca ggctgaacaa      180

agaaatagag acttgcaggc tgataaccaa agactgaaat atgaagtgga ggcattaaag      240

gagaagctag agcatcaata tgcacagagc tataagcagg tctcagtgtt agaagatgat      300

ttaagtcaga ctcgggccat taaggagcag ttgcataagt atgtgagaga gctggagcag      360

gccaacgacg acctggagcg agccaaaagg gcaacaatag tttcactgga agactttgaa      420

caaaggctaa accaggccat tgaacgaaat gcatttttag aaagtgaact tgatgaaaag      480

gaatctttgt tggtctctgt acagaggtta aaggatgaag caagagattt aaggcaagaa      540

ctagcagttc gggaaagaca acaggaagta actagaaagt cggctcctag ctctccaact      600

ctagactgtg aaaagatgga ctccgccgtc caagcatcac tttctttgcc agctacccct      660

gttggcaaag gaacggagaa cacttttcct tcaccgaaag ctataccaaa tggttttggt      720

accagtccac taactccctc tgctaggata tcagcactaa acatcgtggg ggatctctta      780

cggaaagtag gggctttaga atccaaatta gcagcttgca ggaattttgc aaaggaccaa      840

gcatcacgaa aatcctatat ttcagggaat gttaactgtg gggtgctgaa tggcaatggc      900

acaaagttct ctcgatcagg gcatacatct ttcttcgaca aaggggcagt aaacggcttt      960

gaccccgctc ctcctcctcc tggtctgggc tcctcgcgtc catcgtcagc gccgggtatg     1020

ctgcctctca gtgtgtga                                                   1038


<210>  401
<211>  666
<212>  DNA
<213>  Homo sapiens;

<400>  401
atggcgttgg cgttggcggc gctggcggcg gtcgagccgg cctgcggcag ccggtaccag       60

cagttgcaga atgaagaaga gtctggagaa cctgaacagg ctgcaggtga tgctcctcca      120

ccttacagca gcatttctgc agagagcgca gcatattttg actacaagga tgagtctggg      180

tttccaaagc ccccatctta caatgtagct acaacactgc ccagttatga tgaagcggag      240

aggaccaagg ctgaagctac tatccctttg gttcctggga gagatgagga ttttgtgggt      300

cgggatgatt ttgatgatgc tgaccagctg aggataggaa atgatgggat tttcatgtta      360

acttttttca tggcattcct ctttaactgg attgggtttt tcctgtcttt ttgcctgacc      420

acttcagctg caggaaggta tggggccatt tcaggatttg gtctctctct aattaaatgg      480

atcctgattg tcaggttttc cacctatttc cctggatatt ttgatggtca gtactggctc      540

tggtgggtgt tccttgtttt aggctttctc ctgtttctca gaggatttat caattatgca      600

aaagttcgga agatgccaga aactttctca aatctcccca ggaccagagt tctctttatt      660

tattaa                                                                 666


<210>  402
<211>  792
<212>  DNA
<213>  Homo sapiens;

<400>  402
atggaggaga gcgggtacga gtcggtgctc tgtgtcaagc ctgacgtcca cgtctaccgc       60

atccctccgc gggctaccaa ccgtggctac agggctgcgg agtggcagct ggaccagcca      120

tcatggagtg gccggctgag gatcactgca aagggacaga tggcctacat caagctggag      180

gacaggacgt caggggagct ctttgctcag gccccggtgg atcagtttcc tggcacagct      240

gtggagagtg tgacggattc cagcaggtac ttcgtgatcc gcatcgaaga tggaaatggg      300

cgacgggcgt ttattggaat tggcttcggg gaccgaggtg atgcctttga cttcaatgtt      360

gcattgcagg accatttcaa gtgggtgaaa cagcagtgtg aatttgcaaa acaagcccag      420

aacccagacc aaggccctaa actggacctg ggcttcaagg agggccagac catcaagctc      480

aacatcgcaa acatgaagaa gaaggaagga gcagctggga atccccgagt ccggcctgcc      540

agcacaggag ggctgagcct gcttccccct cccccagggg ggaaaacctc caccctgatc      600

cctccccctg gggagcagtt ggctgtgggg ggatccctcg tccagccagc agttgctccc      660

agttcaggag gtgctcctgt accctggcca cagcccaatc ctgccactgc tgacatctgg      720

ggagacttta ccaaatctac aggatcaact tccagccaga cccagccagg cacaggctgg      780

gtccagttct ga                                                          792


<210>  403
<211>  909
<212>  DNA
<213>  Homo sapiens;

<400>  403
atggatgagc aatcacaagg aatgcaaggg ccacctgttc ctcagttcca accacagaag       60

gccttacgac cggatatggg ctataataca ttagccaact ttcgaataga aaagaaaatt      120

ggtcgcggac aatttagtga agtttataga gcagcctgtc tcttggatgg agtaccagta      180

gctttaaaaa aagtgcagat atttgattta atggatgcca aagcacgtgc tgattgcatc      240

aaagaaatag atcttcttaa gcaactcaac catccaaatg taataaaata ttatgcatca      300

ttcattgaag ataatgaact aaacatagtt ttggaactag cagatgctgg cgacctatcc      360

agaatgatca agcattttaa gaagcaaaag aggctaattc ctgaaagaac tgtttggaag      420

tattttgttc agctttgcag tgcattggaa cacatgcatt ctcgaagagt catgcataga      480

gatataaaac cagctaatgt gttcattaca gccactgggg tggtaaaact tggagatctt      540

gggcttggcc ggtttttcag ctcaaaaacc acagctgcac attctttagt tggtacgcct      600

tattacatgt ctccagagag aatacatgaa aatggataca acttcaaatc tgacatctgg      660

tctcttggct gtctactata tgagatggct gcattacaaa gtcctttcta tggtgacaaa      720

atgaatttat actcactgtg taagaagata gaacagtgtg actacccacc tcttccttca      780

gatcactatt cagaagaact ccgacagtta gttaatatgt gcatcaaccc agatccagag      840

aagcgaccag acgtcaccta tgtttatgac gtagcaaaga ggatgcatgc atgcactgca      900

agcagctaa                                                              909


<210>  404
<211>  2910
<212>  DNA
<213>  Homo sapiens;

<400>  404
atggcagaag atgatccata tttgggaagg cctgaacaaa tgtttcattt ggatccttct       60

ttgactcata caatatttaa tccagaagta tttcaaccac agatggcact gccaacagca      120

gatggcccat accttcaaat attagagcaa cctaaacaga gaggatttcg tttccgttat      180

gtatgtgaag gcccatccca tggtggacta cctggtgcct ctagtgaaaa gaacaagaag      240

tcttaccctc aggtcaaaat ctgcaactat gtgggaccag caaaggttat tgttcagttg      300

gtcacaaatg gaaaaaatat ccacctgcat gcccacagcc tggtgggaaa acactgtgag      360

gatgggatct gcactgtaac tgctggaccc aaggacatgg tggtcggctt cgcaaacctg      420

ggtatacttc atgtgacaaa gaaaaaagta tttgaaacac tggaagcacg aatgacagag      480

gcgtgtataa ggggctataa tcctggactc ttggtgcacc ctgaccttgc ctatttgcaa      540

gcagaaggtg gaggggaccg gcagctggga gatcgggaaa aagagctaat ccgccaagca      600

gctctgcagc agaccaagga gatggacctc agcgtggtgc ggctcatgtt tacagctttt      660

cttccggata gcactggcag cttcacaagg cgcctggaac ccgtggtatc agacgccatc      720

tatgacagta aagcccccaa tgcatccaac ttgaaaattg taagaatgga caggacagct      780

ggatgtgtga ctggagggga ggaaatttat cttctttgtg acaaagttca gaaagatgac      840

atccagattc gattttatga agaggaagaa aatggtggag tctgggaagg atttggagat      900

ttttccccca cagatgttca tagacaattt gccattgtct tcaaaactcc aaagtataaa      960

gatattaata ttacaaaacc agcctctgtg tttgtccagc ttcggaggaa atctgacttg     1020

gaaactagtg aaccaaaacc tttcctctac tatcctgaaa tcaaagataa agaagaagtg     1080

cagaggaaac gtcagaagct catgcccaat ttttcggata gtttcggcgg tggtagtggt     1140

gctggagctg gaggcggagg catgtttggt agtggcggtg gaggaggggg cactggaagt     1200

acaggtccag ggtatagctt cccacactat ggatttccta cttatggtgg gattactttc     1260

catcctggaa ctactaaatc taatgctggg atgaagcatg gaaccatgga cactgaatct     1320

aaaaaggacc ctgaaggttg tgacaaaagt gatgacaaaa acactgtaaa cctctttggg     1380

aaagttattg aaaccacaga gcaagatcag gagcccagcg aggccaccgt tgggaatggt     1440

gaggtcactc taacgtatgc aacaggaaca aaagaagaga gtgctggagt tcaggataac     1500

ctctttctag agaaggctat gcagcttgca aagaggcatg ccaatgccct tttcgactac     1560

gcggtgacag gagacgtgaa gatgctgctg gccgtccagc gccatctcac tgctgtgcag     1620

gatgagaatg gggacagtgt cttacactta gcaatcatcc accttcattc tcaacttgtg     1680

agggatctac tagaagtcac atctggtttg atttctgatg acattatcaa catgagaaat     1740

gatctgtacc agacgccctt gcacttggca gtgatcacta agcaggaaga tgtggtggag     1800

gatttgctga gggctggggc cgacctgagc cttctggacc gcttgggtaa ctctgttttg     1860

cacctagctg ccaaagaagg acatgataaa gttctcagta tcttactcaa gcacaaaaag     1920

gcagcactac ttcttgacca ccccaacggg gacggtctga atgccattca tctagccatg     1980

atgagcaata gcctgccatg tttgctgctg ctggtggccg ctggggctga cgtcaatgct     2040

caggagcaga agtccgggcg cacagcactg cacctggctg tggagcacga caacatctca     2100

ttggcaggct gcctgctcct ggagggtgat gcccatgtgg acagtactac ctacgatgga     2160

accacacccc tgcatatagc agctgggaga gggtccacca ggctggcagc tcttctcaaa     2220

gcagcaggag cagatcccct ggtggagaac tttgagcctc tctatgacct ggatgactct     2280

tgggaaaatg caggagagga tgaaggagtt gtgcctggaa ccacgcctct agatatggcc     2340

accagctggc aggtatttga catattaaat gggaaaccat atgagccaga gtttacatct     2400

gatgatttac tagcacaagg agacatgaaa cagctggctg aagatgtgaa gctgcagctg     2460

tataagttac tagaaattcc tgatccagac aaaaactggg ctactctggc gcagaaatta     2520

ggtctgggga tacttaataa tgccttccgg ctgagtcctg ctccttccaa aacacttatg     2580

gacaactatg aggtctctgg gggtacagtc agagagctgg tggaggccct gagacaaatg     2640

ggctacaccg aagcaattga agtgatccag gcagcctcca gcccagtgaa gaccacctct     2700

caggcccact cgctgcctct ctcgcctgcc tccacaaggc agcaaataga cgagctccga     2760

gacagtgaca gtgtctgcga cagcggcgtg gagacatcct tccgcaaact cagctttacc     2820

gagtctctga ccagtggtgc ctcactgcta actctcaaca aaatgcccca tgattatggg     2880

caggaaggac ctctagaagg caaaatttag                                      2910


<210>  405
<211>  1044
<212>  DNA
<213>  Homo sapiens;

<400>  405
atggagcagt atacagcaaa cagcaatagt tcgacagagc agattgttgt ccaggcagga       60

cagattcagc agcagcagca gggtggtgtc actgctgtgc agttgcagac tgaggcccag      120

gtggcatccg cctcaggcca gcaagtccag accctccagg tagtccaagg gcagccatta      180

atggtgcagg tcagtggagg ccagctaatc acatcaactg gccaacccat catggtccag      240

gctgtccctg gtggacaagg tcaaaccatc atgcaagtac ctgtttctgg aacacagggt      300

ttgcagcaaa tacagttggt cccacctgga cagatccaga tccagggtgg acaggctgtg      360

caggtgcagg gccagcaggg ccagacccag cagatcatca tccagcagcc ccagacggct      420

gtcactgctg gccagactca gacacagcag cagattgctg tccagggaca gcaagtggca      480

cagactgctg aagggcagac catcgtctat caaccagtta atgcagatgg caccattctc      540

cagcaagtta cagtccctgt ttcaggcatg atcactatcc cagcagccag tttggcagga      600

gcacagattg ttcaaacagg agccaatacc aacacaacca gcagtgggca agggactgtc      660

actgtgacac taccagtggc aggcaatgtg gtcaattcag gagggatggt catgatggtt      720

cctggggctg gctctgtgcc tgctatccaa agaatccctc tacctggagc agagatgctt      780

gaagaagagc ctctctacgt gaatgccaaa caataccacc gtattcttaa gaggaggcaa      840

gcccgagcta aactagaggc agaagggaaa attccaaagg agagaaggaa atacctgcat      900

gagtctcggc accgtcatgc catggcacgg aagcgtggtg aaggtggacg atttttctct      960

ccaaaggaaa aggatagtcc ccatatgcag gatccaaacc aagccgatga agaagcaatg     1020

acacagatca tccgagtgtc ctaa                                            1044


<210>  406
<211>  4290
<212>  DNA
<213>  Homo sapiens;

<400>  406
atggctggcg gagcctgggg ccgcctggcc tgttacttgg agttcctgaa gaaggaggag       60

ctgaaggagt tccagcttct gctcgccaat aaagcgcact ccaggagctc ttcgggtgag      120

acacccgctc agccagagaa gacgagtggc atggaggtgg cctcgtacct ggtggctcag      180

tatggggagc agcgggcctg ggacctagcc ctccatacct gggagcagat ggggctgagg      240

tcactgtgcg cccaagccca ggaaggggca ggccactctc cctcattccc ctacagccca      300

agtgaacccc acctggggtc tcccagccaa cccacctcca ccgcagtgct aatgccctgg      360

atccatgaat tgccggcggg gtgcacccag ggctcagaga gaagggtttt gagacagctg      420

cctgacacat ctggacgccg ctggagagaa atctctgcct cactcctcta ccaagctctt      480

ccaagctccc cagaccatga gtctccaagc caggagtcac ccaacgcccc cacatccaca      540

gcagtgctgg ggagctgggg atccccacct cagcccagcc tagcacccag agagcaggag      600

gctcctggga cccaatggcc tctggatgaa acgtcaggaa tttactacac agaaatcaga      660

gaaagagaga gagagaaatc agagaaaggc aggcccccat gggcagcggt ggtaggaacg      720

cccccacagg cgcacaccag cctacagccc caccaccacc catgggagcc ttctgtgaga      780

gagagcctct gttccacatg gccctggaaa aatgaggatt ttaaccaaaa attcacacag      840

ctgctacttc tacaaagacc tcaccccaga agccaagatc ccctggtcaa gagaagctgg      900

cctgattatg tggaggagaa tcgaggacat ttaattgaga tcagagactt atttggccca      960

ggcctggata cccaagaacc tcgcatagtc atactgcagg gggctgctgg aattgggaag     1020

tcaacactgg ccaggcaggt gaaggaagcc tgggggagag gccagctgta tggggaccgc     1080

ttccagcatg tcttctactt cagctgcaga gagctggccc agtccaaggt ggtgagtctc     1140

gctgagctca tcggaaaaga tgggacagcc actccggctc ccattagaca gatcctgtct     1200

aggccagagc ggctgctctt catcctcgat ggtgtagatg agccaggatg ggtcttgcag     1260

gagccgagtt ctgagctctg tctgcactgg agccagccac agccggcgga tgcactgctg     1320

ggcagtttgc tggggaaaac tatacttccc gaggcatcct tcctgatcac ggctcggacc     1380

acagctctgc agaacctcat tccttctttg gagcaggcac gttgggtaga ggtcctgggg     1440

ttctctgagt ccagcaggaa ggaatatttc tacagatatt tcacagatga aaggcaagca     1500

attagagcct ttaggttggt caaatcaaac aaagagctct gggccctgtg tcttgtgccc     1560

tgggtgtcct ggctggcctg cacttgcctg atgcagcaga tgaagcggaa ggaaaaactc     1620

acactgactt ccaagaccac cacaaccctc tgtctacatt accttgccca ggctctccaa     1680

gctcagccat tgggacccca gctcagagac ctctgctctc tggctgctga gggcatctgg     1740

caaaaaaaga cccttttcag tccagatgac ctcaggaagc atgggttaga tggggccatc     1800

atctccacct tcttgaagat gggtattctt caagagcacc ccatccctct gagctacagc     1860

ttcattcacc tctgtttcca agagttcttt gcagcaatgt cctatgtctt ggaggatgag     1920

aaggggagag gtaaacattc taattgcatc atagatttgg aaaagacgct agaagcatat     1980

ggaatacatg gcctgtttgg ggcatcaacc acacgtttcc tattgggcct gttaagtgat     2040

gagggggaga gagagatgga gaacatcttt cactgccggc tgtctcaggg gaggaacctg     2100

atgcagtggg tcccgtccct gcagctgctg ctgcagccac actctctgga gtccctccac     2160

tgcttgtacg agactcggaa caaaacgttc ctgacacaag tgatggccca tttcgaagaa     2220

atgggcatgt gtgtagaaac agacatggag ctcttagtgt gcactttctg cattaaattc     2280

agccgccacg tgaagaagct tcagctgatt gagggcaggc agcacagatc aacatggagc     2340

cccaccatgg tagtcctgtt caggtgggtc ccagtcacag atgcctattg gcagattctc     2400

ttctccgtcc tcaaggtcac cagaaacctg aaggagctgg acctaagtgg aaactcgctg     2460

agccactctg cagtgaagag tctttgtaag accctgagac gccctcgctg cctcctggag     2520

accctgcggt tggctggctg tggcctcaca gctgaggact gcaaggacct tgcctttggg     2580

ctgagagcca accagaccct gaccgagctg gacctgagct tcaatgtgct cacggatgct     2640

ggagccaaac acctttgcca gagactgaga cagccgagct gcaagctaca gcgactgcag     2700

ctggtcagct gtggcctcac gtctgactgc tgccaggacc tggcctctgt gcttagtgcc     2760

agccccagcc tgaaggagct agacctgcag cagaacaacc tggatgacgt tggcgtgcga     2820

ctgctctgtg aggggctcag gcatcctgcc tgcaaactca tacgcctggg gctggaccag     2880

acaactctga gtgatgagat gaggcaggaa ctgagggccc tggagcagga gaaacctcag     2940

ctgctcatct tcagcagacg gaaaccaagt gtgatgaccc ctactgaggg cctggatacg     3000

ggagagatga gtaatagcac atcctcactc aagcggcaga gactcggatc agagagggcg     3060

gcttcccatg ttgctcaggc taatctcaaa ctcctggacg tgagcaagat cttcccaatt     3120

gctgagattg cagaggaaag ctccccagag gtagtaccgg tggaactctt gtgcgtgcct     3180

tctcctgcct ctcaagggga cctgcatacg aagcctttgg ggactgacga tgacttctgg     3240

ggccccacgg ggcctgtggc tactgaggta gttgacaaag aaaagaactt gtaccgagtt     3300

cacttccctg tagctggctc ctaccgctgg cccaacacgg gtctctgctt tgtgatgaga     3360

gaagcggtga ccgttgagat tgaattctgt gtgtgggacc agttcctggg tgagatcaac     3420

ccacagcaca gctggatggt ggcagggcct ctgctggaca tcaaggctga gcctggagct     3480

gtggaagctg tgcacctccc tcactttgtg gctctccaag ggggccatgt ggacacatcc     3540

ctgttccaaa tggcccactt taaagaggag gggatgctcc tggagaagcc agccagggtg     3600

gagctgcatc acatagttct ggaaaacccc agcttctccc ccttgggagt cctcctgaaa     3660

atgatccata atgccctgcg cttcattccc gtcacctctg tggtgttgct ttaccaccgc     3720

gtccatcctg aggaagtcac cttccacctc tacctgatcc caagtgactg ctccattcgg     3780

aaggaactgg agctctgcta tcgaagccct ggagaagacc agctgttctc ggagttctac     3840

gttggccact tgggatcagg gatcaggctg caagtgaaag acaagaaaga tgagactctg     3900

gtgtgggagg ccttggtgaa accaggagat ctcatgcctg caactactct gatccctcca     3960

gcccgcatag ccgtaccttc acctctggat gccccgcagt tgctgcactt tgtggaccag     4020

tatcgagagc agctgatagc ccgagtgaca tcggtggagg ttgtcttgga caaactgcat     4080

ggacaggtgc tgagccagga gcagtacgag agggtgctgg ctgagaacac gaggcccagc     4140

cagatgcgga agctgttcag cttgagccag tcctgggacc ggaagtgcaa agatggactc     4200

taccaagccc tgaaggagac ccatcctcac ctcattatgg aactctggga gaagggcagc     4260

aaaaagggac tcctgccact cagcagctga                                      4290


<210>  407
<211>  3123
<212>  DNA
<213>  Homo sapiens;

<400>  407
atgggggaag agggtggttc agcctctcac gatgaggagg aaagagcaag tgtcctcctc       60

ggacattctc cgggttgtga aatgtgctcg caggaggctt ttcaggcaca gaggagccag      120

ctggtcgagc tgctggtctc agggtccctg gaaggcttcg agagtgtcct ggactggctg      180

ctgtcctggg aggtcctctc ctgggaggac tacgagggct tccacctcct gggccagcct      240

ctctcccact tggccaggcg ccttctggac accgtctgga ataagggtac ttgggcctgt      300

cagaagctca tcgcggctgc ccaagaagcc caggccgaca gccagtcccc caagctgcat      360

ggctgctggg acccccactc gctccaccca gcccgagacc tgcagagtca ccggccagcc      420

attgtcagga ggctccacag ccatgtggag aacatgctgg acctggcatg ggagcggggt      480

ttcgtcagcc agtatgaatg tgatgaaatc aggttgccga tcttcacacc gtcccagagg      540

gcaagaaggc tgcttgatct tgccacggtg aaagcgaatg gattggctgc cttccttcta      600

caacatgttc aggaattacc agtcccattg gccctgcctt tggaagctgc cacatgcaag      660

aagtatatgg ccaagctgag gaccacggtg tctgctcagt ctcgcttcct cagtacctat      720

gatggagcag agacgctctg cctggaggac atatacacag agaatgtcct ggaggtctgg      780

gcagatgtgg gcatggctgg acccccgcag aagagcccag ccaccctggg cctggaggag      840

ctcttcagca cccctggcca cctcaatgac gatgcggaca ctgtgctggt ggtgggtgag      900

gcgggcagtg gcaagagcac gctcctgcag cggctgcact tgctgtgggc tgcagggcaa      960

gacttccagg aatttctctt tgtcttccca ttcagctgcc ggcagctgca gtgcatggcc     1020

aaaccactct ctgtgcggac tctactcttt gagcactgct gttggcctga tgttggtcaa     1080

gaagacatct tccagttact ccttgaccac cctgaccgtg tcctgttaac ctttgatggc     1140

tttgacgagt tcaagttcag gttcacggat cgtgaacgcc actgctcccc gaccgacccc     1200

acctctgtcc agaccctgct cttcaacctt ctgcagggca acctgctgaa gaatgcccgc     1260

aaggtggtga ccagccgtcc ggccgctgtg tcggcgttcc tcaggaagta catccgcacc     1320

gagttcaacc tcaagggctt ctctgaacag ggcatcgagc tgtacctgag gaagcgccat     1380

catgagcccg gggtggcgga ccgcctcatc cgcctgctcc aagagacctc agccctgcac     1440

ggtttgtgcc acctgcctgt cttctcatgg atggtgtcca aatgccacca ggaactgttg     1500

ctgcaggagg gggggtcccc aaagaccact acagatatgt acctgctgat tctgcagcat     1560

tttctgctgc atgccacccc cccagactca gcttcccaag gtctgggacc cagtcttctt     1620

cggggccgcc tccccaccct cctgcacctg ggcagactgg ctctgtgggg cctgggcatg     1680

tgctgctacg tgttctcagc ccagcagctc caggcagcac aggtcagccc tgatgacatt     1740

tctcttggct tcctggtgcg tgccaaaggt gtcgtgccag ggagtacggc gcccctggaa     1800

ttccttcaca tcactttcca gtgcttcttt gccgcgttct acctggcact cagtgctgat     1860

gtgccaccag ctttgctcag acacctcttc aattgtggca ggccaggcaa ctcaccaatg     1920

gccaggctcc tgcccacgat gtgcatccag gcctcggagg gaaaggacag cagcgtggca     1980

gctttgctgc agaaggccga gccgcacaac cttcagatca cagcagcctt cctggcaggg     2040

ctgttgtccc gggagcactg gggcctgctg gctgagtgcc agacatctga gaaggccctg     2100

ctccggcgcc aggcctgtgc ccgctggtgt ctggcccgca gcctccgcaa gcacttccac     2160

tccatcccgc cagctgcacc gggtgaggcc aagagcgtgc atgccatgcc cgggttcatc     2220

tggctcatcc ggagcctgta cgagatgcag gaggagcggc tggctcggaa ggctgcacgt     2280

ggcctgaatg ttgggcacct caagttgaca ttttgcagtg tgggccccac tgagtgtgct     2340

gccctggcct ttgtgctgca gcacctccgg cggcccgtgg ccctgcagct ggactacaac     2400

tctgtgggtg acattggcgt ggagcagctg ctgccttgcc ttggtgtctg caaggctctg     2460

tatttgcgcg ataacaatat ctcagaccga ggcatctgca agctcattga atgtgctctt     2520

cactgcgagc aattgcagaa gttagctcta ttcaacaaca aattgactga cggctgtgca     2580

cactccatgg ctaagctcct tgcatgcagg cagaacttct tggcattgag gctggggaat     2640

aactacatca ctgccgcggg agcccaagtg ctggccgagg ggctccgagg caacacctcc     2700

ttgcagttcc tgggattctg gggcaacaga gtgggtgacg agggggccca ggccctggct     2760

gaagccttgg gtgatcacca gagcttgagg tggctcagcc tggtggggaa caacattggc     2820

agtgtgggtg cccaagcctt ggcactgatg ctggcaaaga acgtcatgct agaagaactc     2880

tgcctggagg agaaccatct ccaggatgaa ggtgtatgtt ctctcgcaga aggactgaag     2940

aaaaattcaa gtttgaaaat cctgaagttg tccaataact gcatcaccta cctaggggca     3000

gaagccctcc tgcaggccct tgaaaggaat gacaccatcc tggaagtctg gctccgaggg     3060

aacactttct ctctagagga ggttgacaag ctcggctgca gggacaccag actcttgctt     3120

tga                                                                   3123


<210>  408
<211>  906
<212>  DNA
<213>  Homo sapiens;

<400>  408
atgacgcggc atggcaagaa ctgcaccgca ggggccgtct acacctacca cgagaagaag       60

aaggacacag cggcctcggg ctatgggacc cagaacattc gactgagccg ggatgccgtg      120

aaggacttcg actgctgttg tctctccctg cagccttgcc acgatcctgt tgtcacccca      180

gatggctacc tgtatgagcg tgaggccatc ctggagtaca ttctgcacca gaagaaggag      240

attgcccggc agatgaaggc ctacgagaag cagcggggca cccggcgcga ggagcagaag      300

gagcttcagc gggcggcctc gcaggaccat gtgcggggct tcctggagaa ggagtcggct      360

atcgtgagcc ggcccctcaa ccctttcaca gccaaggccc tctcgggcac cagcccagat      420

gatgtccaac ctgggcccag tgtgggtcct ccaagtaagg acaaggacaa agtgctgccc      480

agcttctgga tcccgtcgct gacgcccgaa gccaaggcca ccaagctgga gaagccgtcc      540

cgcacggtga cctgccccat gtcagggaag cccctgcgca tgtcggacct gacgcccgtg      600

cacttcacac cgctagacag ctccgtggac cgcgtggggc tcatcacccg cagcgagcgc      660

tacgtgtgtg ccgtgacccg cgacagcctg agcaacgcca ccccctgcgc tgtgctgcgg      720

ccctctgggg ctgtggtcac cctcgaatgc gtggagaagc tgattcggaa ggacatggtg      780

gaccctgtga ctggagacaa actcacagac cgcgacatca tcgtgctgca gcggggcggt      840

accggcttcg cgggctccgg agtgaagctg caagcggaga aatcacggcc ggtgatgcag      900

gcctga                                                                 906


<210>  409
<211>  963
<212>  DNA
<213>  Homo sapiens;

<400>  409
atggccttcc caaagaagaa acttcagggt cttgtggctg caaccatcac gccaatgact       60

gagaatggag aaatcaactt ttcagtaatt ggtcagtatg tggattatct tgtgaaagaa      120

cagggagtga agaacatttt tgtgaatggc acaacaggag aaggcctgtc cctgagcgtc      180

tcagagcgtc gccaggttgc agaggagtgg gtgacaaaag ggaaggacaa gctggatcag      240

gtgataattc acgtaggagc actgagcttg aaggagtcac aggaactggc ccaacatgca      300

gcagaaatag gagctgatgg catcgctgtc attgcaccgt tcttcctcaa gccatggacc      360

aaagatatcc tgattaattt cctaaaggaa gtggctgctg ccgcccctgc cctgccattt      420

tattactatc acattcctgc cttgacaggg gtaaagattc gtgctgagga gttgttggat      480

gggattctgg ataagatccc caccttccaa gggctgaaat tcagtgatac agatctctta      540

gacttcgggc aatgtgttga tcagaatcgc cagcaacagt ttgctttcct ttttggggtg      600

gatgagcaac tgttgagtgc tctggtgatg ggagcaactg gagcagtggg cagtacctat      660

aactacctgg gaaaaaagac aaaccagatg ttggaggctt ttgaacaaaa ggacttctct      720

ttagccctga actatcagtt ttgtatccag agatttatca actttgttgt caaactaggt      780

tttggagtgt cacagaccaa agccatcatg actctggtct ctgggattcc aatgggccca      840

ccccggcttc cactgcagaa agcctccagg gagtttactg atagtgctga agctaaactg      900

aagagcctgg atttcctttc tttcactgat ttaaaggatg gaaacttgga agctggtagc      960

tag                                                                    963


<210>  410
<211>  2334
<212>  DNA
<213>  Homo sapiens;

<400>  410
atggactcca aagaatcatt aactcctggt agagaagaaa accccagcag tgtgcttgct       60

caggagaggg gagatgtgat ggacttctat aaaaccctaa gaggaggagc tactgtgaag      120

gtttctgcgt cttcaccctc actggctgtc gcttctcaat cagactccaa gcagcgaaga      180

cttttggttg attttccaaa aggctcagta agcaatgcgc agcagccaga tctgtccaaa      240

gcagtttcac tctcaatggg actgtatatg ggagagacag aaacaaaagt gatgggaaat      300

gacctgggat tcccacagca gggccaaatc agcctttcct cgggggaaac agacttaaag      360

cttttggaag aaagcattgc aaacctcaat aggtcgacca gtgttccaga gaaccccaag      420

agttcagcat ccactgctgt gtctgctgcc cccacagaga aggagtttcc aaaaactcac      480

tctgatgtat cttcagaaca gcaacatttg aagggccaga ctggcaccaa cggtggcaat      540

gtgaaattgt ataccacaga ccaaagcacc tttgacattt tgcaggattt ggagttttct      600

tctgggtccc caggtaaaga gacgaatgag agtccttgga gatcagacct gttgatagat      660

gaaaactgtt tgctttctcc tctggcggga gaagacgatt cattcctttt ggaaggaaac      720

tcgaatgagg actgcaagcc tctcatttta ccggacacta aacccaaaat taaggataat      780

ggagatctgg ttttgtcaag ccccagtaat gtaacactgc cccaagtgaa aacagaaaaa      840

gaagatttca tcgaactctg cacccctggg gtaattaagc aagagaaact gggcacagtt      900

tactgtcagg caagctttcc tggagcaaat ataattggta ataaaatgtc tgccatttct      960

gttcatggtg tgagtacctc tggaggacag atgtaccact atgacatgaa tacagcatcc     1020

ctttctcaac agcaggatca gaagcctatt tttaatgtca ttccaccaat tcccgttggt     1080

tccgaaaatt ggaataggtg ccaaggatct ggagatgaca acttgacttc tctggggact     1140

ctgaacttcc ctggtcgaac agttttttct aatggctatt caagccccag catgagacca     1200

gatgtaagct ctcctccatc cagctcctca acagcaacaa caggaccacc tcccaaactc     1260

tgcctggtgt gctctgatga agcttcagga tgtcattatg gagtcttaac ttgtggaagc     1320

tgtaaagttt tcttcaaaag agcagtggaa ggacagcaca attacctatg tgctggaagg     1380

aatgattgca tcatcgataa aattcgaaga aaaaactgcc cagcatgccg ctatcgaaaa     1440

tgtcttcagg ctggaatgaa cctggaagct cgaaaaacaa agaaaaaaat aaaaggaatt     1500

cagcaggcca ctacaggagt ctcacaagaa acctctgaaa atcctggtaa caaaacaata     1560

gttcctgcaa cgttaccaca actcacccct accctggtgt cactgttgga ggttattgaa     1620

cctgaagtgt tatatgcagg atatgatagc tctgttccag actcaacttg gaggatcatg     1680

actacgctca acatgttagg agggcggcaa gtgattgcag cagtgaaatg ggcaaaggca     1740

ataccaggtt tcaggaactt acacctggat gaccaaatga ccctactgca gtactcctgg     1800

atgtttctta tggcatttgc tctggggtgg agatcatata gacaatcaag tgcaaacctg     1860

ctgtgttttg ctcctgatct gattattaat gagcagagaa tgactctacc ctgcatgtac     1920

gaccaatgta aacacatgct gtatgtttcc tctgagttac acaggcttca ggtatcttat     1980

gaagagtatc tctgtatgaa aaccttactg cttctctctt cagttcctaa ggacggtctg     2040

aagagccaag agctatttga tgaaattaga atgacctaca tcaaagagct aggaaaagcc     2100

attgtcaaga gggaaggaaa ctccagccag aactggcagc ggttttatca actgacaaaa     2160

ctcttggatt ctatgcatga agtggttgaa aatctcctta actattgctt ccaaacattt     2220

ttggataaga ccatgagtat tgaattcccc gagatgttag ctgaaatcat caccaatcag     2280

ataccaaaat attcaaatgg aaatatcaaa aaacttctgt ttcatcaaaa gtga           2334


<210>  411
<211>  864
<212>  DNA
<213>  Homo sapiens;

<400>  411
atggaagtaa tggaaggacc cctcaacctg gctcatcaac agagcagacg agcagaccgt       60

ttattagctg caggcaaata cgaagaggct atttcttgtc acaaaaaggc tgcagcatat      120

ctttctgaag ccatgaagct gacacagtca gagcaggctc atctttcact ggaattgcaa      180

agggatagcc atatgaaaca gctcctcctc atccaagaga gatggaaaag ggcccagcgt      240

gaagaaagat tgaaagccca gcagaacaca gacaaggatg cagctgccca tcttcagaca      300

tctcacaaac cctctgcaga ggatgcagag ggccagagtc ccctttctca gaagtacagc      360

ccttccacag agaaatgcct gcctgagatt caggggatct ttgacaggga tccagacaca      420

ctactttatt tacttcagca aaagagtgag ccagcagagc catgtattgg aagcaaagcc      480

ccaaaagatg ataaaacaat tatagaggag caggcaacca aaattgcaga tttgaagagg      540

catgtggaat tccttgtggc tgagaatgaa agattaagga aagaaaataa acaactaaag      600

gctgaaaagg ccagacttct aaaaggtcca atagaaaagg agctggatgt agatgctgat      660

tttgtagaaa cgtcagagtt atggagcttg ccaccacatg cagaaactgc tacagcctcc      720

tcaacctggc agaagttcgc agcaaatact gggaaagcca aggacattcc aatccccaat      780

cttcctccct tggattttcc atctccagaa cttcctctta tggagctctc tgaggatatt      840

ctgaaaggat ttatgaataa ttaa                                             864


<210>  412
<211>  1023
<212>  DNA
<213>  Homo sapiens;

<400>  412
atgctgaccc agctgaaagc aaaatcagag gggaagcttg caaaacagat ttgcaaagtt       60

gtgttggatc attttgaaaa acagtattcc aaagaactcg gagatgcctg gaatacagta      120

agggagatac taacatctcc atcatgctgg caatatgctg tcctgcttaa ccgattcaat      180

tatccttttg aactggaaaa ggatttacat ttgaagggct atcacacact ctctcaggga      240

tctttaccca actatcctaa atcagtgaag tgttacctta gcagaactcc gggccgaatc      300

ccttcagaaa gacaccaaat tggaaacctg aaaaaatatt atctcctaaa tgctgcttct      360

cttctcccag tgttggctct ggaattaagg gatggggaga aggttctgga tctctgtgct      420

gctcctggag ggaaatcaat agctctgctg cagtgtgctt gtccaggtta tcttcattgt      480

aatgaatatg atagtctgag attgaggtgg ctaaggcaga cgttggaatc tttcatccca      540

cagcctttga taaatgtaat taaagtgtct gaattggatg gcagaaaaat gggagatgcc      600

cagcctgaaa tgtttgacaa ggtgttagtg gatgctccgt gttcaaatga tcgaagctgg      660

ttgttttctt ctgactctca gaaggcatcc tgtaggataa gtcaaaggag gaatttgcct      720

cttctacaga tagagctgtt aaggtctgca attaaggcct tacgtcctgg agggatactt      780

gtatactcta catgcacgct ttccaaggca gaaaatcaag atgtgatcag tgaaatttta      840

aactcccacg gtaacatcat gcctatggac attaaaggaa tagcaaggac ttgctcccac      900

gacttcacat ttgctcccac tggccaggaa tgtgggctct tagtgattcc agataagggc      960

aaagcctggg gcccaatgta tgtagccaaa ttgaagaaat catggagcac aggaaaatgg     1020

tga                                                                   1023


<210>  413
<211>  1923
<212>  DNA
<213>  Homo sapiens;

<400>  413
atgaacaaat tacggcaaag ttttaggaga aagaaggatg tttatgttcc agaggccagt       60

cgtccacatc agtggcagac agatgaagaa ggcgttcgca ccggaaaatg tagcttcccg      120

gttaagtacc ttggccatgt agaagttgat gaatcaagag gaatgcacat ctgtgaagat      180

gctgtaaaaa gattgaaagc tactggaaag aaagcagtta aagcagttct gtgggtctca      240

gcagatggac tcagagttgt ggatgaaaaa actaaggacc tcatagttga ccagacgata      300

gagaaagttt ctttctgtgc cccagacagg aactttgata gagccttttc ttacatatgc      360

cgtgatggca ccactcgtcg ctggatctgt cactgcttca tggctgtcaa ggacacaggt      420

gaaaggttga gccatgcagt aggctgtgct tttgcagcct gtttagagcg caagcagaag      480

cgggagaagg aatgtggagt gactgctact tttgatgcta gtcggaccac ttttacaaga      540

gaaggatcat tccgtgtcac aacagccact gaacaagcag aaagagagga gatcatgaaa      600

caaatgcaag atgccaagaa agctgaaaca gataagatag tcgttggttc atcagttgcc      660

cctggcaaca ctgccccatc cccatcctct cccacctctc ctacttctga tgccacgacc      720

tctctggaga tgaacaatcc tcatgccatc ccacgccggc atgctccaat tgaacagctt      780

gctcgccaag gctctttccg aggttttcct gctcttagcc agaagatgtc accctttaaa      840

cgccaactat ccctacgcat caatgagttg ccttccacta tgcagaggaa gactgatttc      900

cccattaaaa atgcagtgcc agaagtagaa ggggaggcag agagcatcag ctccctgtgc      960

tcacagatca ccaatgcctt cagcacacct gaggacccct tctcatctgc tccgatgacc     1020

aaaccagtga cagtggtggc accacaatct cctaccttcc aagctaatgg cactgactca     1080

gccttccatg tgcttgctaa gccagcccat actgctctag cacccgtagc aatgcctgtg     1140

cgtgaaacca acccttgggc ccatgcccct gatgctgcta acaaggaaat tgcagccaca     1200

tgttcgggga ccgagtgggg tcaatcttct ggtgctgcct ctccaggtct cttccaggcc     1260

ggtcatagac gtactccctc tgaggccgac cgatggttag aagaggtgtc taagagcgtc     1320

cgggctcagc agccccaggc ctcagctgct cctctgcagc cagttctcca gcctcctcca     1380

cccactgcca tctcccagcc agcatcacct ttccaaggga atgcattcct cacctctcag     1440

cctgtgccag tgggtgtggt cccagccctg caaccagcct ttgtccctgc ccagtcctat     1500

cctgtggcca atggaatgcc ctatccagcc cctaatgtgc ctgtggtggg catcactccc     1560

tcccagatgg tggccaacgt atttggcact gcaggccacc ctcaggctgc ccatccccat     1620

cagtcaccca gcctggtcag gcagcagaca ttccctcact acgaggcaag cagtgctacc     1680

accagtccct tctttaagcc tcctgctcag cacctcaacg gttctgcagc tttcaatggt     1740

gtagatgatg gcaggttggc ctcagcagac aggcatacag aggttcctac aggcacctgc     1800

ccagtggatc cttttgaagc ccagtgggct gcattagaaa ataagtccaa gcagcgtact     1860

aatccctccc ctaccaaccc tttctccagt gacttacaga agacgtttga aattgaactt     1920

taa                                                                   1923


<210>  414
<211>  2064
<212>  DNA
<213>  Homo sapiens;

<400>  414
atgggaaatg gggagtccca gctgtcctcg gtgcctgctc agaagctggg ttggtttatc       60

caggaatacc tgaagcccta cgaagaatgt cagacactga tcgacgagat ggtgaacacc      120

atctgtgacg tcctgcagga acccgaacag ttccccctgg tgcagggagt ggccataggt      180

ggctcctatg gacggaaaac agtcttaaga ggcaactccg atggtaccct tgtcctcttc      240

ttcagtgact taaaacaatt ccaggatcag aagagaagcc aacgtgacat cctcgataaa      300

actggggata agctgaagtt ctgtctgttc acgaagtggt tgaaaaacaa tttcgagatc      360

cagaagtccc ttgatgggtt caccatccag gtgttcacaa aaaatcagag aatctctttc      420

gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata atcccagccc ctggatctat      480

cgagagctca aaagatcctt ggataagaca aatgccagtc ctggtgagtt tgcagtctgc      540

ttcactgaac tccagcagaa gttttttgac aaccgtcctg gaaaactaaa ggatttgatc      600

ctcttgataa agcactggca tcaacagtgc cagaaaaaaa tcaaggattt accctcgctg      660

tctccgtatg ccctggagct gcttacggtg tatgcctggg aacaggggtg cagaaaagac      720

aactttgaca ttgctgaagg cgtcagaacc gtactggagc tgatcaaatg ccaggagaag      780

ctgtgtatct attggatggt caactacaac tttgaagatg agaccatcag gaacatcctg      840

ctgcaccagc tccaatcagc gaggccagta atcttggatc cagttgaccc aaccaataat      900

gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag aagctcaaac ctggttgact      960

tctcccaacc tggataatga gttacctgca ccatcttgga atgttctgcc tgcaccactc     1020

ttcacgaccc caggccacct tctggataag ttcatcaagg agtttctcca gcccaacaaa     1080

tgcttcctag agcagattga cagtgctgtt aacatcatcc gtacattcct taaagaaaac     1140

tgcttccgac aatcaacagc caagatccag attgtccggg gaggatcaac cgccaaaggc     1200

acagctctga agactggctc tgatgccgat ctcgtcgtgt tccataactc acttaaaagc     1260

tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg aaatccatga acagctgaaa     1320

gccttttgga gggagaagga ggaggagctt gaagtcagct ttgagcctcc caagtggaag     1380

gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc tcaacgaaag tgtcagcttt     1440

gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt ctggctccac acccagcccc     1500

gaggtttatg cagggctcat tgatctgtat aaatcctcgg acctcccggg aggagagttt     1560

tctacctgtt tcacagtcct gcagcgaaac ttcattcgct cccggcccac caaactaaag     1620

gatttaattc gcctggtgaa gcactggtac aaagagtgtg aaaggaaact gaagccaaag     1680

gggtctttgc ccccaaagta tgccttggag ctgctcacca tctatgcctg ggagcagggg     1740

agtggagtgc cggattttga cactgcagaa ggtttccgga cagtcctgga gctggtcaca     1800

caatatcagc agctctgcat cttctggaag gtcaattaca actttgaaga tgagaccgtg     1860

aggaagtttc tactgagcca gttgcagaaa accaggcctg tgatcttgga cccagccgaa     1920

cccacaggtg acgtgggtgg aggggaccgt tggtgttggc atcttctggc aaaagaagca     1980

aaggaatggt tatcctctcc ctgcttcaag gatgggactg gaaacccaat accaccttgg     2040

aaagtgccgg taaaagtcat ctaa                                            2064


<210>  415
<211>  1545
<212>  DNA
<213>  Homo sapiens;

<400>  415
atggcactga tgcaggaact gtatagcaca ccagcctcca ggctggactc cttcgtggct       60

cagtggctgc agccccaccg ggagtggaag gaagaggtgc tagacgctgt gcggaccgtg      120

gaggagtttc tgaggcagga gcatttccag gggaagcgtg ggctggacca ggatgtgcgg      180

gtgctgaagg tagtcaaggt gggctccttc gggaatggca cggttctcag gagcaccaga      240

gaggtggagc tggtggcgtt tctgagctgt ttccacagct tccaggaggc agccaagcat      300

cacaaagatg ttctgaggct gatatggaaa accatgtggc aaagccagga cctgctggac      360

ctcgggctcg aggacctgag gatggagcag agagtccccg atgctctcgt cttcaccatc      420

cagaccaggg ggactgcgga gcccatcacg gtcaccattg tgcctgccta cagagccctg      480

gggccttctc ttcccaactc ccagccaccc cctgaggtct atgtgagcct gatcaaggcc      540

tgcggtggtc ctggaaattt ctgcccatcc ttcagcgagc tgcagagaaa tttcgtgaaa      600

catcggccaa ctaagctgaa gagcctcctg cgcctggtga aacactggta ccagcagtat      660

gtgaaagcca ggtcccccag agccaatctg ccccctctct atgctcttga acttctaacc      720

atctatgcct gggaaatggg tactgaagaa gacgagaatt tcatgttgga cgaaggcttc      780

accactgtga tggacctgct cctggagtat gaagtcatct gtatctactg gaccaagtac      840

tacacactcc acaatgcaat cattgaggat tgtgtcagaa aacagctcaa aaaagagagg      900

cccatcatcc tggatccggc cgaccccacc ctcaacgtgg cagaagggta cagatgggac      960

atcgttgctc agagggcctc ccagtgcctg aaacaggact gttgctatga caacagggag     1020

aaccccatct ccagctggaa cgtgaagagg gcacgagaca tccacttgac agtggagcag     1080

aggggttacc cagatttcaa cctcatcgtg aacccttatg agcccataag gaaggttaaa     1140

gagaaaatcc ggaggaccag gggctactct ggcctgcagc gtctgtcctt ccaggttcct     1200

ggcagtgaga ggcagcttct cagcagcagg tgctccttag ccaaatatgg gatcttctcc     1260

cacactcaca tctatctgct ggagaccatc ccctccgaga tccaggtctt cgtgaagaat     1320

cctgatggtg ggagctacgc ctatgccatc aaccccaaca gcttcatcct gggtctgaag     1380

cagcagattg aagaccagca ggggcttcct aaaaagcagc agcagctgga attccaaggc     1440

caagtcctgc aggactggtt gggtctgggg atctatggca tccaagacag tgacactctc     1500

atcctctcga agaagaaagg agaggctctg tttccagcca gttag                     1545


<210>  416
<211>  1356
<212>  DNA
<213>  Homo sapiens;

<400>  416
atgggcaacc tgctcggcgg ggtcagcttc cgcgagccca ccaccgtgga ggactgcgac       60

tccacctggc agaccgactc ggagcccgag cccgaagaac cagggccggg cggcggcagc      120

gagggcccgg ggcaggagtc cgagcagccc gcgcagcccc cggagcaagc cggcgggcgg      180

cccggcgcca gccccgcgcc ggacgaggac gccgaggcgg cgggcgccga gcagggtggt      240

gattccactg aagcaactgc caaaccaaag agaagttttt atgctgccag ggatttgtac      300

aagtaccgac accagtaccc aaacttcaaa gatatccgat atcaaaatga cttgagcaat      360

cttcgttttt ataagaataa aattccattc aagccagatg gtgtttacat tgaagaagtt      420

ctaagtaaat ggaaaggaga ttatgaaaaa ctggagcaca accacactta cattcaatgg      480

cttttccccc tgagagaaca aggcttgaac ttctatgcca aagaactaac tacatatgaa      540

attgaggaat tcaaaaaaac aaaagaagca attagaagat tcctcctggc ttataaaatg      600

atgctagaat tttttggaat aaaactgact gataaaactg gaaatgttgc tcgggctgtt      660

aactggcagg aaagatttca gcatctgaat gagtcccagc acaactattt aagaatcact      720

cgtattctta aaagccttgg tgagcttgga tatgaaagtt ttaaatctcc tcttgtaaaa      780

tttattcttc atgaagctct tgtggagaat actattccca atattaagca gagtgctcta      840

gagtattttg tttatacaat tagagacaga agagaaagga gaaagctcct gcggttcgcc      900

cagaaacact acacgccttc agagaacttt atctggggac cgcctcgaaa agaacagtcg      960

gagggaagca aagcccagaa aatgtcttcc cctctcgcct ccagtcataa cagtcaaact     1020

tctatgcaca aaaaagccaa ggactccaaa aattcctcct cagctgttca tttaaatagc     1080

aaaacagctg aagacaaaaa agtggcacca aaagagcctg tggaagagac agacaggccc     1140

agcccagagc ccagcaatga agctgccaag ccaagaaata cagagaagga cagtaatgct     1200

gagaacatga attctcaacc tgagaaaaca gttactactc ccacagaaaa aaaggagagt     1260

gtatctcctg agaataacga agaaggtgga aatgataacc aagacaatga aaatcctgga     1320

aatacaaatt gccatgatgt tgtactagta cagtga                               1356


<210>  417
<211>  2244
<212>  DNA
<213>  Homo sapiens;

<400>  417
atgcaggggg gtgaaccagt gtccacaatg aaagtctcgg agagcgaagg aaagctggag       60

ggccaggcca cagcggtgac cccgaacaag aacagcagct gtggaggtgg aatcagtagc      120

agcagcagca gccgcggtgg cagtgcaaaa ggctggcagt acagtgatca catggaaaat      180

gtgtatggct atttaatgaa gtataccaac cttgtcactg ggtggcagta caggtttttt      240

gttttaaaca atgaagctgg gctgttggag tactttgtga atgaacagtc tagaaatcag      300

aaacctagag gaactttgca gcttgcagga gctgtaatat cacccagtga tgaggattct      360

cacaccttca ctgtaaacgc tgccagtggg gaacaatata aactcagagc tacagatgca      420

aaagagcgac agcactgggt tagcagactt cagatatgta cacagcatca tactgaagct      480

attggaaaga ataatcctcc tctgaagtca cggagcttct cacttgcatc tagtagtaat      540

tctcctatat cgcagaggag accaagtcaa aatgccattt ctttttttaa tgttggacat      600

tccaaactgc aatcactgag caaaagaact aatttacctc cagaccatct tgtggaagtc      660

agagaaatga tgtctcatgc tgaaggacaa caaagagact taattagacg aattgaatgc      720

cttcctactt ctggccatct tagttccttg gaccaggatc tcttaatgct caaagctact      780

tccatggcaa ctatgaactg cttaaatgac tgctttcata ttctccagtt acagcatgca      840

tcacatcaga agggctcatt gccttcagga acgacaatcg agtggttaga accaaagata      900

tctttatcaa accactataa aaatggagct gaccagccct ttgcaactga tcagagtaag      960

ccggtggcag tcccagaaga gcagcctgtt gcagaatctg gactattagc gagggagcct     1020

gaagaaataa atgcagatga tgagatagag gatacatgtg accacaaaga ggatgacctg     1080

ggagctgtag aagaacaacg tagtgtcatc ctacatctct tgtcacagct taagctgggc     1140

atggatttaa caagagtggt gcttcctaca tttatcctag agaagcgttc cttgctggaa     1200

atgtatgcag actttatgtc tcatccagac ctatttatag ccatcactaa tggagccaca     1260

gctgaggaca gaatgattcg ctttgttgag tactacctta cctcatttca tgaaggccgt     1320

aagggagcca ttgctaaaaa accatacaat cctatcattg gagaaacatt tcactgttcc     1380

tggaagatgc caaaaagcga ggtagcatcc agtgttttta gcagttcttc cacccaggga     1440

gtcacaaatc atgctccttt atcgggggag tctttgaccc aggtgggatc agactgttac     1500

acagtcagat ttgttgctga gcaggtttct catcatcctc cagtctcagg attttatgca     1560

gaatgtacag agaggaagat gtgtgtaaat gcgcatgtct ggactaagag caagttctta     1620

ggcatgtcaa taggcgtgac aatggttgga gaaggtatcc ttagtctgtt ggagcatgga     1680

gaagagtaca cattttctct accctgtgca tatgctcggt caattttgac tgttccttgg     1740

gtagaactgg gtggcaaagt cagtgtcaac tgtgcaaaaa ctggatattc agccagcatc     1800

acttttcata ccaagccatt ttatggtggc aaactgcatc gggttacagc tgaagtaaag     1860

cacaacatca ccaacactgt ggtatgcaga gtgcaagggg aatggaatag tgttcttgag     1920

ttcacatata gcaatggaga gacaaagtat gtggacttga ctaaattggc agtgacgaag     1980

aaaagagtga gacctctgga gaagcaggat ccatttgaat ccaggcgatt gtggaaaaat     2040

gtgacagact cgctgagaga atctgaaatt gataaggcca cagagcataa gcataccctg     2100

gaagaacgtc agaggactga agaaaggcat cgtactgaaa caggcacacc ttggaaaacc     2160

aaatatttta ttaaagaggg agatggctgg gtttatcata aaccactttg gaaaataatt     2220

ccaacaacac aaccagcaga gtga                                            2244


<210>  418
<211>  1407
<212>  DNA
<213>  Homo sapiens;

<400>  418
atgaacggag aggaagaatt ctttgatgcc gtcacagagg caaatcagaa agtcacggga       60

atgattgact tagacaccag caaaaataat aggattggga aaactgggga gaggccctct      120

caagagaacg gaattcagaa acacaggaca tcgctgccgg ctcccatgtt cagcagaagc      180

gacttcagcg tgtggaccat cctgaagaag tgtgttggcc tggagctgtc caagatcacg      240

atgccaatcg ccttcaacga gcctctgagc ttcttgcagc ggatcacgga gtacatggag      300

cacgtgtacc tcatccacag ggcctcctgc cagccccagc ccctggagag gatgcagtct      360

gtggctgctt ttgctgtttc ggctgtggct tcccagtggg agaggaccgg caaaccattt      420

aatccactct tgggagaaac gtatgaatta atcagggaag atttaggatt cagatttata      480

tcggaacagg tcagtcacca cccccccatc agtgcgttcc actcggaagg tctcaaccat      540

gacttcctgt tccatggctc catctacccc aagctcaagt tctggggcaa aagcgtggag      600

gcggagcccc gaggcaccat caccctggag ctgctcaaac ataatgaagc ctacacctgg      660

accaacccca cctgctgcgt ccacaacgtc atcatcggga agctgtggat agagcagtat      720

gggacagtgg agattttaaa ccacagaact ggacataagt gtgtgcttca ctttaaaccg      780

tgtggattat ttggaaaaga acttcacaag gtggaaggac acattcaaga caaaaacaaa      840

aagaagctct ttatgatcta tggcaaatgg acggaatgtt tgtggggcat agatcctgtt      900

tcgtatgaat ccttcaagaa gcaggagagg agaggtgacc acctgagaaa ggccaagctg      960

gatgaagact ccgggaaggc tgacagcgac gtggctgacg acgtgcctgt ggcccaggag     1020

accgtgcagg tcattcctgg cagcaagctg ctctggagga tcaacacccg gccccccaac     1080

tctgcccaga tgtataattt caccagtttc actgtgagcc tcaacgagct ggagacaggc     1140

atggagaaga ccctgccacc cacggactgc cgcctgcgcc ctgacatccg cggcatggag     1200

aatggcaaca tggatctggc cagccaggag aaggagcggc tggaggagaa gcagagagaa     1260

gcacggaggg agcgggccaa ggaggaggca gagtggcaga cgaggtggtt ctacccaggc     1320

aataacccct acactgggac ccccgactgg ttgtatgcag gggattactt tgagcggaat     1380

ttctccgact gcccagatat ctactga                                         1407


<210>  419
<211>  1461
<212>  DNA
<213>  Homo sapiens;

<400>  419
atgtctgtca catatgatga ttccgttgga gtagaagtgt ccagcgacag cttctgggag       60

gtcgggaact acaagcggac tgtgaagcgg atcgacgatg gccaccgcct gtgcagcgac      120

ctcatgaact gcctgcatga gcgggcgcgc atcgagaagg cgtatgcgca gcagctcact      180

gagtgggccc ggcgctggag gcagctcgtg gagaaagggc cccagtacgg gaccgtggag      240

aaggcctgga tggccttcat gtccgaggca gagagggtga gcgagctgca cctcgaggtg      300

aaggcctcac tgatgaacga tgacttcgag aagatcaaga actggcagaa ggaagccttt      360

cacaagcaga tgatgggcgg cttcaaggag accaaggaag ctgaggacgg ctttcggaag      420

gcacagaagc cctgggccaa gaagctgaaa gaggtagaag cagcaaagaa agcccaccat      480

gcagcgtgca aagaggagaa gctggctatc tcacgagaag ccaacagcaa ggcagaccca      540

tccctcaacc ctgaacagct caagaaattg caagacaaaa tagaaaagtg caagcaagat      600

gttcttaaga ccaaagagaa gtatgagaag tccctgaagg aactcgacca gggcacaccc      660

cagtacatgg agaacatgga gcaggtgttt gagcagtgcc agcagttcga ggagaaacgc      720

cttcgcttct tccgggaggt tctgctggag gttcagaagc acctagacct gtccaatgtg      780

gctggctaca aagccattta ccatgacctg gagcagagca tcagagcagc tgatgcagtg      840

gaggacctga ggtggttccg agccaatcac gggccgggca tggccatgaa ctggccgcag      900

tttgaggagt ggtccgcaga cctgaatcga accctcagcc ggagagagaa gaagaaggcc      960

actgacggcg tcaccctgac gggcatcaac cagacaggcg accagtctct gccgagtaag     1020

cccagcagca cccttaatgt cccgagcaac cccgcccagt ctgcgcagtc acagtccagc     1080

tacaacccct tcgaggatga ggacgacacg ggcagcaccg tcagtgagaa ggacgacact     1140

aaggccaaaa atgtgagcag ctacgagaag acccagagct atcccaccga ctggtcagac     1200

gatgagtcta acaacccctt ctcctccacg gatgccaatg gggactcgaa tccattcgac     1260

gacgacgcca cctcggggac ggaagtgcga gtccgggccc tgtatgacta tgaggggcag     1320

gagcatgatg agctgagctt caaggctggg gatgagctga ccaagatgga ggacgaggat     1380

gagcagggct ggtgcaaggg acgcttggac aacgggcaag ttggcctata cccggcaaat     1440

tatgtggagg cgatccagtg a                                               1461


<210>  420
<211>  1233
<212>  DNA
<213>  Homo sapiens;

<400>  420
atggtgctgt cccagagaca acgagatgaa ctaaatcgag ctatagcaga ttatcttcgt       60

tcaaatggct atgaagaggc atattcagtt tttaaaaagg aagctgaatt agatgtgaat      120

gaagaattag ataaaaagta tgctggtctt ttggaaaaaa aatggacatc tgttattaga      180

ttacaaaaga aggttatgga attagaatca aagctaaatg aagcaaaaga agaatttacg      240

tcaggtggac ctcttggtca gaaacgagac ccaaaagaat ggattccccg tccgccagaa      300

aaatatgcat tgagtggtca caggagtcca gtcactcgag tcattttcca tcctgtgttc      360

agtgttatgg tctctgcttc agaggatgct acaattaagg tgtgggatta tgagactgga      420

gattttgaac gaactcttaa aggacataca gactctgtac aggacatttc attcgaccac      480

agcggcaagc ttctggcttc ctgttctgca gatatgacca ttaaactatg ggattttcag      540

ggctttgaat gcatcagaac catgcacggc catgaccaca atgtttcttc agtagccatc      600

atgcccaatg gagatcatat agtgtctgcc tcaagggata aaactataaa aatgtgggaa      660

gtgcaaactg gctactgtgt gaagacattc acaggacaca gagaatgggt acgtatggta      720

cggccaaatc aagatggcac tctgatagcc agctgttcca atgaccagac tgtgcgtgta      780

tgggtcgtag caacaaagga atgcaaggct gagctccgag agcatgagca tgtggtagaa      840

tgcatttcct gggctccaga aagctcatat tcctccatct ctgaagcaac aggatctgag      900

actaaaaaaa gtggtaaacc tgggccattc ttgctgtctg gatccagaga caagactatt      960

aagatgtggg atgtcagtac tggcatgtgc cttatgaccc tcgtgggtca tgataactgg     1020

gtacgtggag ttctgttcca ttctgggggg aagtttattt tgagttgtgc tgatgacaag     1080

accctacgcg tatgggatta caagaacaag cgatgcatga agaccctcaa tgcgcatgaa     1140

cactttgtta cctccttgga tttccacaag acggcaccct atgtcgtcac tggcagcgta     1200

gatcaaacag taaaagtgtg ggagtgccgt tga                                  1233


<210>  421
<211>  2106
<212>  DNA
<213>  Homo sapiens;

<400>  421
atggcccagg ccggcgtcgt cggtgaggtc acccaggtgc tgtgcgcggc cgggggcgcc       60

ctggagttgc ccgagctgcg gcgccgcttg cggatgggct tgagcgccga cgcgctggag      120

cggctgctgc ggcagcgtgg gcgcttcgtg gtggcggtgc gggcgggcgg cgcagccgcg      180

gccccggagc gcgtggtgct ggccgcctcg ccgctgcgcc tgtgtcgcgc gcaccagggc      240

tccaagccgg gctgcgtggg gctctgcgcg cagctccacc tctgcaggtt catggtctac      300

ggcgcctgca agttcctgag agccgggaag aactgtagga atagtcacag cttgacaacc      360

gaacacaacc tgagtgtgct gagaactcat ggcgttgacc acctgagcta taatgagcta      420

tgccaactct tgtttcagaa cgacccctgg cttttgccag aaatttgcca acattacaac      480

aaaggagatg gaccccacgg ctcttgtgcc tttcaaaagc agtgcatcaa gctccatatc      540

tgccagtatt ttttacaggg ggaatgcaag tttggcacta gctgtaagag atcccatgat      600

ttctctaatt ctgagaatct ggaaaaattg gagaagttgg gtatgagctc agacctggtg      660

agcaggctgc ctaccattta tagaaatgca catgacatca agaataagag ctctgccccc      720

agcagagtgc ctcctctttt tgtcccacag gggacttctg aaagaaaaga cagttcaggt      780

tctgtgtccc caaacactct tagccaggag gagggtgatc agatctgttt gtaccatatc      840

cggaaaagtt gtagctttca agataagtgc catagagttc atttccattt gccgtatcga      900

tggcaattct tggatagagg caaatgggag gatttggaca acatggaact tattgaagag      960

gcatattgca atcccaaaat agaaaggatc ctgtgctctg agtcagccag tacctttcac     1020

tctcattgtc tgaactttaa cgccatgact tacggtgcta cccaggctcg ccgcctctcc     1080

acggcctcct ctgtcaccaa acctccacac ttcatcctca ccactgactg gatttggtac     1140

tggagtgatg agtttggttc ttggcaggaa tatggaagac agggcacggt gcaccctgtg     1200

accactgtca gcagtagcga cgtggagaag gcctacctgg cctactgtac accggggtct     1260

gacggccagg cagccacctt gaagttccag gccggaaagc acaactacga gttagatttc     1320

aaagccttcg ttcagaaaaa cctggtctat ggcacaacta aaaaggtttg ccgcagaccc     1380

aaatacgtgt ctccccagga tgtgacgacc atgcaaacct gcaataccaa gtttccaggc     1440

ccgaagagca tcccagacta ttgggactcc tctgccctgc cagacccagg ctttcagaag     1500

atcaccctta gttcttcctc ggaagagtat cagaaggtct ggaacctctt taaccgcacg     1560

ctgcctttct actttgttca gaagattgag cgagtacaga acctggccct ctgggaagtc     1620

taccagtggc aaaaaggaca gatgcagaag cagaacggag ggaaggccgt ggacgagcgg     1680

cagctgttcc acggcaccag cgccattttt gtggacgcca tctgccagca gaactttgac     1740

tggcgggtct gtggtgttca tggcacttcc tacggcaagg ggagctactt tgcccgagat     1800

gctgcatatt cccaccacta cagcaaatcc gacacgcaga cccacacgat gttcctggcc     1860

cgggtgctgg tgggcgagtt cgtcaggggc aatgcctcct ttgtccgtcc gccggccaag     1920

gagggctgga gcaacgcctt ctatgatagc tgcgtgaaca gtgtgtccga cccctccatc     1980

tttgtgatct ttgagaaaca ccaggtctac ccagagtatg tcatccagta caccacctcc     2040

tccaagccct cggtcacacc ctccatcctg ctggccttgg gctccctgtt cagcagccga     2100

cagtga                                                                2106


<210>  422
<211>  1305
<212>  DNA
<213>  Homo sapiens;

<400>  422
atggacgatc aatccaggat gctgcagact ctggccgggg tgaacctggc tggccactcg       60

gtgcaggggg gcatggccct gccgcctccc ccgcacggcc acgaaggggc ggacggcgac      120

ggcaggaagc aggacatcgg cgacatcctc caccagatca tgaccatcac cgaccagagc      180

ttggacgagg cgcaagcaaa gaaacatgcc ctgaactgtc acagaatgaa accagcgctc      240

ttcagcgtcc tgtgtgagat caaagagaaa acaggtctca gcatcagagg agcccaggag      300

gaggaccctc ccgatcccca gctaatgaga ctggacaata tgcttttggc agaaggggtt      360

tcaggtcctg agaaaggtgg gggatcggcg gcagcagctg cagccgcggc agcctctgga      420

ggttcttcag ataactctat tgaacactca gattacagag ccaaattgac ccagatcaga      480

caaatctatc acacagaact ggagaaatat gaacaggcat gtaatgaatt tactacacat      540

gtgatgaacc ttctccgaga acagagtaga acacgtccca tttctccaaa agagattgaa      600

agaatggtgg gcatcatcca tcgaaaattt agttccattc agatgcagct caaacaaagc      660

acttgtgaag cagttatgat tttaagatca aggttccttg atgccagacg gaaaaggcgt      720

aacttcagta aacaggccac agaaatcttg aatgaatatt tttactcaca cctcagcaac      780

ccctacccca gtgaagaagc caaagaggag ctggccaaga aatgcagcat cacagtgtca      840

caggtatcca attggtttgg caacaaacga atcaggtaca agaagaacat tggcaagttt      900

caggaagaag ccaacctcta tgctgcaaag acggccgtga cagctgcaca cgcagtagca      960

gcagctgtgc agaacaacca gaccaattcg cccaccacac caaattccgg ttcttctggt     1020

tcttttaacc tcccaaattc tggggacatg ttcatgaaca tgcagagtct gaatggggat     1080

tcttaccaag ggtcccaagt cggagccaat gtgcaatcac aggtggatac cctccgtcat     1140

gttatcaatc agacgggagg ctacagtgat ggccttggag gaaattcact gtacagtcca     1200

cataatttaa atgctaatgg aggctggcag gacgcaacaa ctccatcttc tgtgacttct     1260

cctacagaag gcccaggaag tgtgcactcg gatacctcta actaa                     1305


<210>  423
<211>  1101
<212>  DNA
<213>  Homo sapiens;

<400>  423
atggacaccg gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg       60

catggaaagg aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc      120

gaggagagtg gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact      180

ttggctggac ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa      240

gaggacataa gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg      300

aggctggtgg tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc      360

aaggaaatac gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac      420

tcaactgagc gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa      480

cagatctgcg tggtcatgtt ggagactctc tcccagtccc ccccgaaggg cgtgaccatc      540

ccgtaccggc ccaagccgtc cagctctccg gtcatctttg caggtggtca ggacaggtac      600

agcacaggca gcgacagtgc gagctttccc cacaccaccc cgtccatgtg cctcaaccct      660

gacctggagg gaccacctct agaggcctat accattcaag gacagtatgc cattccacag      720

ccagatttga ccaagctgca ccagttggca atgcaacagt ctcattttcc catgacgcat      780

ggcaacaccg gattcagtgg cattgaatcc agctctccag aggtgaaagg ctattgggca      840

ggtttggatg catctgctca gactacttct catgaactca ccattccaaa cgatttgatt      900

ggctgcataa tcgggcgtca aggcgccaaa atcaatgaga tccgtcagat gtctggggcg      960

cagatcaaaa ttgcgaaccc agtggaagga tctactgata ggcaggttac catcactgga     1020

tctgctgcca gcattagcct ggctcaatat ctaatcaatg tcaggctttc ctcggagacg     1080

ggtggcatgg ggagcagcta g                                               1101


<210>  424
<211>  4668
<212>  DNA
<213>  Homo sapiens;

<400>  424
atgtcagagc agacgccggc cgaggccggt gctgcggggg cccgggagga cgcctgtcgg       60

gattatcagt catcgctcga agacctgacc ttcaatagca agccgcacat caatatgctg      120

accattctag ccgaggagaa cctgcccttc gccaaggaga tcgtctctct catcgaggcc      180

caaaccgcca aggctccttc ctcagagaag cttcctgtta tgtaccttat ggattctatt      240

gtgaaaaacg ttggaagaga gtatctcact gcctttacta aaaatctagt tgcaacattt      300

atttgtgtgt ttgaaaaggt ggatgaaaat actaggaaaa gtttatttaa gttacgttct      360

acatgggatg aaatattccc tttgaagaaa ctttatgccc tggatgtcag agtcaattca      420

ttagatcctg cttggcctat taaacctcta ccccccaatg tgaatacgtc tagcatccat      480

gtgaatccta aatttttaaa taaatcgccc gaggagcctt caacacctgg tacagtggtc      540

agttccccta gcatctccac tcctccaatt gttcctgata tacaaaagaa tcttacacaa      600

gaacaactaa taaggcagca gttactggca aagcaaaaac agttgttaga acttcagcag      660

aaaaagctgg agcttgagct agagcaagct aaggcacagt tggcagtttc tcttagtgtt      720

cagcaggaaa catccaattt aggtcctgga tctgcaccat ccaaattaca tgtttcacag      780

attcccccta tggcagttaa agctcctcat caggttcctg tgcaatctga gaaaagccgt      840

ccaggaccat ccttacaaat tcaggattta aaaggaacta accgggatcc tcgtctgaac      900

aggataagcc aacattctca tggaaaagat cagagtcaca ggaaagaatt tctaatgaac      960

acattaaacc agtctgatac taagacaagt aaaactatac cctctgaaaa actaaattca     1020

tccaagcaag aaaaaagtaa atcaggtgaa aaaataacca agaaagaact tgaccaatta     1080

gattctaaat cgaaatcgaa atcgaaatca ccctcacctt tgaaaaacaa attatctcac     1140

acaaaagact tgaaaaatca agaatcggaa agtatgaggt tgtctgatat gaacaagaga     1200

gatccaagat taaaaaaaca tcttcaggat aagaccgatg gcaaagatga tgatgtgaaa     1260

gagaagagaa aaactgcaga aaaaaaggat aaagatgagc acatgaagtc atccgaacac     1320

agactggctg gaagtagaaa taaaatcata aatggcattg tacaaaaaca ggatacaata     1380

acagaagagt cagaaaaaca ggggacaaaa ccagggagat cgagtactag aaagcgatca     1440

agatctcgat cacccaagtc taggtcacca attatacatt ccccaaagag aagagatagg     1500

cggtcaccca aacgaaggca aagaagtatg tctccaacat cgacacctaa agctggaaag     1560

attcgccaat ctggagctaa gcagtcacat atggaagagt ttacaccacc ttctagggaa     1620

gacagaaatg ctaagagaag tactaaacag gatattcggg atccaaggcg aatgaaaaag     1680

actgaagagg agcgaccaca agaaactaca aatcagcatt ctacaaagtc aggcactgaa     1740

ccaaaggaga atgtagaaaa ctggcaaagt tccaagtctg ccaaaagatg gaaatctggt     1800

tgggaagaaa ataaaagctt acaacaggtt gatgaacata gtaaacctcc tcatctgagg     1860

catagggaga gctggtcaag cactaaagga attttatcac ctcgagcccc aaagcagcaa     1920

cagcatcgat taagtgtaga tgccaatctt cagattccta aagagttaac tcttgcaagc     1980

aaaagagaat tacttcaaaa gacgagtgaa cgtttagcat ctggtgaaat tacacaggat     2040

gacttccttg ttgttgtgca tcaaattcga cagctatttc agtatcaaga aggtgtgcga     2100

gaagagcaga gatctccatt caatgatcgt tttccactta agcgacctcg atatgaagat     2160

tcagataaac catttgtaga tagtccagca tcaagattcg ccggcctgga tacaaatcag     2220

cgacttacag ctttagctga agacagaccg ttatttgatg gacctagtag gccatcagta     2280

gcaagagatg gcccaacgaa gatgattttt gaaggaccca ataaattaag ccctcgaatt     2340

gatggacctc ccacaccagc ttctcttcgg tttgatgggt caccaggaca aatgggggga     2400

ggaggccctt tgagatttga ggggccacaa ggtcagctag gaggtgggtg tcctttgaga     2460

tttgaaggtc ctccaggacc agtggggaca cctctgcggt ttgagggccc aattggtcaa     2520

gcaggaggag gtggttttcg gtttgaaggt tcccctggtc tgaggtttga gggatctcca     2580

ggtggtttga gatttgaggg accaggaggc cagcctgtgg gtggtctgag gtttgaggga     2640

catcgtggtc aacctgtggg tggtctaagg tttgagggac ctcatggtca gcctgtgggt     2700

ggacttagat ttgataatcc ccgaggtcag cctgtaggtg gacttagatt tgaggggggt     2760

catggtccat caggggctgc gattaggttt gatggacctc atggtcagcc aggaggtgga     2820

atcagatttg agggcccttt gctacagcaa ggggttggaa tgaggtttga gggcccccat     2880

ggtcagtcag tagctggtct gagatttgag ggacaacata atcaacttgg tgggaacctt     2940

aggtttgagg gtccacatgg tcagccaggg gttggtatca ggtttgaagg ccctttagtc     3000

caacaaggag gtggaatgag gtttgagggt ccttctgtac caggaggtgg cctgagaatt     3060

gaagggcctc tgggtcaagg tggtccaaga tttgaaggtt gtcatgcttt aaggtttgat     3120

gggcagccag gtcagccgtc actcttgcca agatttgatg gattacatgg tcagccaggt     3180

cctagatttg aaaggactcc tggtcagcca ggccctcaga ggtttgatgg accacctgga     3240

cagcaggttc aacccagatt tgacggtgta cctcaaagat ttgatggtcc acaacatcag     3300

caagcatcaa ggtttgatat tcctcttggt cttcaaggca caagatttga caatcatcct     3360

tcacaaaggc ttgaatcagt atctttcaat cagactggtc catataatga tccacctggc     3420

aatgctttta atgccccatc ccaaggacta cagttccaaa gacatgaaca aatatttgat     3480

tcacctcaag gaccaaattt taatggacca catggccctg gaaaccagag tttctctaat     3540

ccacttaaca gagcttctgg acactatttt gatgaaaaaa atcttcagag ttctcaattt     3600

ggaaactttg gcaatatacc tgctccaatg acagtaggaa atattcaggc atctcaacag     3660

gttctgagtg gtgttgctca gccagtagct tttggtcaag gacaacagtt tttaccagtt     3720

catccacaaa atcctggatt tgttcagaat ccttcaggag ccctccctaa ggcatatcct     3780

gataatcatc tcagtcaggt ggatgtaaat gaattgtttt caaaattgct aaaaacagga     3840

attctcaaat tgtcccaaac tgattcagct acaacacaag taagtgaagt aactgctcag     3900

cctccccctg aagaggagga agatcaaaat gaagatcaag atgttccaga tcttactaat     3960

tttacagttg aagaattgaa acaacgttat gacagtgtta taaatcgact gtacactggt     4020

attcagtgtt actcttgtgg aatgaggttt acaacatcac agacagatgt ttatgcagat     4080

catttggact ggcattatcg gcaaaataga actgaaaagg atgttagccg aaaagtcact     4140

catagacgtt ggtactacag tttaacagac tggatagaat ttgaggagat agctgatctg     4200

gaagaacggg caaagagcca gttttttgaa aaggtgcatg aagaagttgt gctcaaaact     4260

caagaggctg ctaaagaaaa agagttccaa agtgtacctg ctggaccagc tggagcagtt     4320

gagagttgtg aaatctgtca agaacaattt gaacaatact gggatgaaga agaggaggaa     4380

tggcatttga aaaatgctat tagagtagat ggaaagattt atcatccatc atgttatgaa     4440

gattatcaaa atacatcttc atttgattgt acaccatctc ccagcaagac accagttgaa     4500

aaccccttga atattatgtt gaacattgtc aaaaacgaat tgcaggaacc ctgtgacagt     4560

cccaaagtta aggaagaacg aattgataca ccaccagctt gtacagagga aagcatagca     4620

acaccctctg aaattaaaac agaaaatgac acagtcgagt cagtttaa                  4668


<210>  425
<211>  7026
<212>  DNA
<213>  Homo sapiens;

<400>  425
atggggtcgc agacgctgca gatcctccga cagggggtgt gggccgcgct cagcgggggc       60

tggtactacg acccgcacca ggccaccttc gtgaacgcgc tgcacctcta cctgtggctc      120

tttctgctgg gcctgccctt caccctctac atggcccttc cttctaccat gattatagta      180

gcagtttatt gtcctgtgat agctgctgtt ttcattgttc tgaagatggt caactatcga      240

ctacacagag cacttgatgc tggagaagtt gtagatagga ctgcaaatga gttcacggat      300

cagcgaacca aagctgaaca aggcaactgt tcaaccagga gaaaagacag caatggaccg      360

agtgatcctg gtggagggat tgaaatgtct gagttcatcc gagaggccac acccccagtt      420

ggttgcagtt ccagaaattc ttatgccggt ctagatccaa gcaaccagat tggatctggt      480

tcctcgcgtc ttggaacagc agcaactatt aaaggagata cagacactgc taagacttct      540

gatgatatca gtttaagtct gggccaaagt tctagtcttt gtaaggaagg aagtgaagaa      600

caagatttgg cagctgatcg gaagctcttt cgtcttgtct ccaatgactc cttcatctct      660

attcagcctt ccttatcctc ttgtggacag gacttgccaa gggacttcag tgacaaagtg      720

aacctgccaa gtcataacca ccaccaccat gttgatcagt ctctgtccag cgcctgtgac      780

acagaagtag cttctcttgt acctttacac tcacactctt atagaaaaga ccaccggccg      840

cgaggtgtac cacggacttc tagctctgct gtggcttttc cagacacttc actgaatgat      900

tttccccttt atcagcaaag acgtggatta gatccagtta gtgagttaga atcttccaag      960

cctctttctg gatccaaaga atccttggtg gaaaattctg gtttatctgg ggaatttcag     1020

cttgctggtg acttgaaaat caatacttct cagccaccca caaaaagtgg gaagagcaaa     1080

cctttgaaag cagagaaaag catggacagc ttgaggagcc tgagcacacg gagtagtggg     1140

tcaacagaaa gctactgcag tggaacggac cgggacacta acagtactgt cagcagctat     1200

aaaagtgagc agaccagctc aactcacata gagagcatcc tgtcagagca tgaggagtct     1260

cctaaagcag gaacaaaaag tgggaggaag aaagagtgct gtgcaggccc agaggagaag     1320

aatagctgtg ccagtgacaa aaggactagc agtgaaaaga ttgctatgga agcgagtacc     1380

aacagtgggg ttcacgaggc caaggacccc accccctctg atgagatgca caaccagaga     1440

ggtctcagca cctctgcatc tgaagaagcc aataaaaatc cccatgcaaa tgaatttact     1500

tcccaagggg acagaccacc tgggaacact gcagaaaaca aagaagagaa gagtgataag     1560

tcagctgttt ctgtggattc caaagtgcgt aaagatgttg gtggaaagca aaaggaaggg     1620

gatgttcgac ctaaatcttc tagcgtaatc catcggacag cttctgccca caagtcaggc     1680

aggagacgca caggaaaaaa acgggctagc agttttgatt caagccggca tagggactat     1740

gtttgctttc gaggtgtttc tggtaccaag ccacacagtg ctatattttg tcatgacgaa     1800

gactctagtg atcagagtga cttgagtaga gcatcaagtg ttcagtctgc tcaccagttc     1860

agcagtgata gctcttctag caccacttct cattcctgtc agtctcctga gggcagatac     1920

agtgctctaa agaccaaaca cactcataaa gaaaggggca cagactctga acacacacac     1980

aaagctcatt tggttcctga aggaaccagc aaaaagcgtg caacacgacg gacttctagc     2040

acaaatagtg ccaagactcg tgcccgagtg ttgagcctgg acagtggcac agtagcatgt     2100

ttgaatgact caaacaggtt aatggcacct gaaagtataa agcccttaac cacttcaaaa     2160

tcagatcttg aggccaaaga gggagaggtg ctagatgagc tatctttatt aggacgggct     2220

tcccagttag agacagtcac tcgatctagg aatagcttgc caaaccaggt tgcatttcct     2280

gaaggggaag agcaagatgc agtcagtgga gcagcacaag ccagcgagga ggcagtgtca     2340

tttcgccgtg aacgcagcac atttaggcgc caggcagtac ggcgccggca caatgcaggg     2400

agtaacccta cccctcctac attgctcatc ggatcacccc taagccttca agatggtcag     2460

caaggccagc agtccacagc ccaggtcaaa gtccagtccc gccccccttc ccaggctgca     2520

gtgctcagtg ctagtgcctc cttgctggtg agaaatggga gtgtccactt agaagcatca     2580

catgacaatg catctgctgt aggcggtagc agtttgcacg atgaacttgg taagttctct     2640

tctacgctgt atgagactgg tggctgtgat atgtcacttg tgaattttga accagcagca     2700

agaagagcat ccaatatctg tgacacagat tctcatgtat ccagttctac ctcagttcga     2760

ttttatccac atgatgtgct ctctctccca cagattcgat tgaatagact attgaccatt     2820

gatacagatt tgttggagca acaggacatt gatctaagcc ctgacttggc agctacttac     2880

ggcccaacag aagaagctgc ccaaaaggtt aaacactatt atcgcttttg gatcctaccc     2940

cagctgtgga ttggcattaa ctttgacaga ctcacacttt tggccctgtt tgatagaaat     3000

cgtgagatcc tggaaaatgt gttagctgtc atcctggcta ttctcgtggc ctttttggga     3060

tctattcttc tcatacaagg attcttcaga gatatctggg tcttccagtt ctgcctcgtc     3120

atagccagct gtcaatactc actgcttaag agtgttcaac cagattcttc ttctcccaga     3180

catggtcata atcgtatcat tgcctacagt agaccagttt atttctgcat atgttgcggt     3240

cttatttggc tcttggatta tggtagcaga aacctgactg caaccaagtt caaattatat     3300

ggaataactt tcaccaatcc actggtgttt atatcagcca gggatttagt tatagtgttt     3360

acactctgtt tcccaatagt gtttttcatt ggtctcctgc ctcaggtgaa tacatttgta     3420

atgtaccttt gtgaacaatt ggatattcat atttttggtg gtaatgccac tacaagcctg     3480

cttgcagcac tttacagttt tatctgtagc attgttgcag tagccttatt gtatggatta     3540

tgttatgggg ctttaaagga ttcttgggat ggccagcata ttccagtact tttctccatt     3600

ttttgtggtt tattagtggc agtgtcttac catctcagcc gacaaagcag tgatccatct     3660

gtacttttct ctttagtgca atccaagatt tttccaaaaa cggaagagaa aaatccagaa     3720

gaccctctat ctgaagtaaa agatccactg cctgaaaaac ttagaaattc tgttagtgag     3780

cgattacagt ctgacctggt agtatgcatt gtaattggtg tgctgtattt tgctattcat     3840

gtaagcacag tcttcacagt attgcagcct gccctcaagt atgtgttgta tacattggtt     3900

ggctttgtgg gttttgtaac ccattatgtg ctgcctcaag ttagaaaaca gctaccatgg     3960

cactgtttct ctcatcctct gctaaagaca ctagagtata atcagtatga agttcgaaat     4020

gcagccacta tgatgtggtt tgagaaactt catgtgtggc ttctttttgt ggagaagaat     4080

ataatctatc cattgattgt tctcaatgaa ctgagcagca gtgcagagac aattgctagt     4140

ccaaagaaac tgaatacaga attaggtgct ttaatgatca ctgttgctgg tttgaagttg     4200

ctacgatcct cttttagcag ccctacatat cagtatgtta cagtcatctt tactgtgctg     4260

tttttcaaat ttgactatga agctttttca gagaccatgc tgttggatct cttctttatg     4320

tccatactct tcaacaagct ttgggaacta ctttataaat tgcagtttgt gtatacctat     4380

attgccccat ggcagatcac atggggttct gctttccatg cttttgctca gccttttgca     4440

gtgcctcatt cagccatgct gtttattcag gctgctgtct cggccttctt ctctactcca     4500

ctgaacccct ttctgggaag tgcaatattc atcacttcat atgtccgacc tgtgaaattc     4560

tgggagagag actataacac aaaacgagtg gatcattcaa ataccagatt ggcttcccag     4620

cttgatagaa atccaggatc agatgacaac aatctgaatt ccatctttta tgagcattta     4680

actagatccc tacagcacag cctctgtggt gatttgctac taggacggtg gggaaactac     4740

agtacagggg actgtttcat ccttgcctct gactatctca atgcattagt acaccttata     4800

gagataggca atggtctggt cacttttcag ctgcggggac ttgaattcag aggtacctac     4860

tgtcaacaac gggaagtgga ggccattact gaaggtgtag aggaagatga aggattttgc     4920

tgttgtgaac ctggccatat tcctcacatg ctttcattta atgctgcatt tagccagcga     4980

tggctagctt gggaagtgat agtcacaaag tacattctgg agggttatag catcactgat     5040

aacagtgctg cttctatgct tcaagtcttt gatcttcgga aagtactcac cacttactat     5100

gtcaagggta tcatttatta tgttacgacc tcgtctaagc tagaggagtg gctagctaat     5160

gagacaatgc aggaaggact tcgtctgtgt gctgatcgca attatgtcga tgtggacccg     5220

acctttaatc caaacattga tgaagactat gaccaccgac tggcaggcat atctagggag     5280

agtttctgtg tgatttacct caactggata gagtactgct cttcccgaag agcaaagcct     5340

gtggatgtgg acaaagattc atccctagtg actctctgtt atggactctg tgttctggga     5400

cggagagctt tggggactgc atcccatcat atgtccagta atttagagtc attcctctat     5460

ggattgcatg ccctatttaa aggagatttc cgtatttctt caattcgaga tgaatggatc     5520

tttgctgaca tggaattgct aagaaaagta gtagtccctg ggatccgtat gtccattaaa     5580

cttcatcagg atcattttac ttctccagat gaatatgatg accctactgt gctctatgaa     5640

gccatagtat ctcatgagaa gaacctcgta atagcccatg aaggggaccc tgcatggcgg     5700

agtgcagtac ttgccaactc tccctccttg cttgctctgc ggcatgtcat ggatgatggc     5760

accaatgaat ataaaatcat catgctcaac agacgctacc tgagcttcag ggtcattaaa     5820

gtgaataagg aatgtgtccg aggtctttgg gcagggcaac agcaggagct tgtttttcta     5880

cgtaaccgta acccagagag aggtagcatc caaaatgcaa agcaagccct gagaaacatg     5940

ataaactcat cttgtgatca acctattggc tacccaatct ttgtctcacc cctgacaact     6000

tcttactctg acagccacga acagcttaaa gacattcttg ggggtcctat cagcttggga     6060

aatatcagga acttcatagt gtcaacctgg cacaggctta ggaaaggttg cggagctgga     6120

tgtaacagtg gtggcaatat tgaagattct gatactggag gtgggacttc ctgcactggt     6180

aacaatgcaa caactgccaa caatccccac agcaacgtga cccagggaag cattggaaat     6240

cctgggcagg gatcaggaac tggactccac ccacctgtca catcttatcc tccaacacta     6300

ggcactagcc acagctctca ctctgtgcag tcgggcctgg tcagacagtc tcctgcccgg     6360

gcctcagtag ccagccagtc ttcctactgc tatagcagcc ggcattcatc cctccggatg     6420

tccaccactg ggtttgtgcc ttgtcggcgc tcttctacta gtcagatatc gcttcgaaac     6480

ttgccatcat ccatccaatc ccgactgtcg atggtgaacc aaatggaacc ctcaggtcag     6540

agcggcctgg cctgtgtgca gcacggcctg ccttcctcca gcagctccag ccaaagcatc     6600

ccagcctgca aacatcacac tctcgtgggc tttcttgcga cagagggagg tcagagcagt     6660

gccactgatg cacagccagg caacacctta agtcctgcca acaattcaca ctccagaaag     6720

gcagaagtga tttacagagt ccaaattgtg gatcccagtc aaattctgga agggatcaac     6780

ctgtctaaaa ggaaagagct acagtggcct gatgaaggaa tccggttaaa agctgggaga     6840

aatagctgga aagactggag tccgcaggag ggcatggaag gccatgtgat tcaccgatgg     6900

gtgccttgca gcagagatcc aggtaccaga tcccacatcg acaaggcagt gcttctggtc     6960

cagattgatg ataaatatgt gactgtaatt gaaactgggg tactagaact tggggctgaa     7020

gtgtga                                                                7026


<210>  426
<211>  2607
<212>  DNA
<213>  Homo sapiens;

<400>  426
atggcgacat tcatctcggt gcagctgaaa aagacctcag aggtggacct ggccaagccg       60

ctggtgaagt tcatccagca gacttaccca agcggcgggg aagagcaggc ccagtactgc      120

cgcgcggcgg aggagctcag caagctgcgc cgcgccgcag tcggtcgtcc gctggacaag      180

cacgagggcg cgctcgagac gctcctgaga tattatgatc agatttgttc tattgaaccc      240

aaattcccat tttctgaaaa tcagatctgc ttgacattta cctggaagga tgctttcgat      300

aaaggttcac tttttggagg ctctgtaaaa ctggctcttg caagcttagg atatgaaaag      360

agctgtgtgt tgttcaattg tgcagcctta gctagccaaa ttgcagcaga acagaacctg      420

gataatgatg aaggattgaa aatcgctgct aaacattacc agtttgctag tggtgccttt      480

ttacatatta aagagacggt tttatctgcc ttaagtcgag agccgaccgt ggacatatct      540

ccagatactg ttgggaccct cagtcttatt atgctggcac aggctcaaga agtatttttt      600

ttaaaagcca caagagataa aatgaaagat gccatcatag ctaaattggc taatcaggct      660

gcagattatt ttggtgatgc tttcaaacag tgtcaataca aagatactct ccccaaggag      720

gtgttccctg tcttggctgc aaagcactgt atcatgcagg ccaatgctga gtaccatcag      780

tctatcctgg caaaacagca gaagaaattt ggagaagaaa ttgcaaggtt acagcatgca      840

gcagaactga ttaaaacagt ggcatctcgc tatgatgaat atgttaatgt gaaggatttt      900

tctgacaaaa tcaatcgtgc ccttgctgca gcaaagaagg ataatgactt catttatcat      960

gatcgagttc cagaccttaa agatctagat cctattggca aagccacact tgtgaaatct     1020

accccggtca atgtacccat cagtcagaaa tttactgatc tgtttgagaa gatggttccc     1080

gtgtcagtac agcagtcttt ggctgcctat aatcagagga aagccgattt ggttaacaga     1140

tcaattgctc agatgagaga agccaccact ttggcaaatg gggtgctagc ttcccttaat     1200

cttccagcag caattgaaga tgtgtctgga gacactgtac ctcagtctat attgactaaa     1260

tccagatctg tgattgaaca gggaggcatc cagactgttg atcagttgat taaagaactg     1320

cctgaattac tgcaacgaaa tagagaaatc ctagatgagt cattaaggtt gttggatgaa     1380

gaagaagcaa ccgataatga tttaagagca aaatttaagg aacgttggca aaggacacca     1440

tccaatgaac tgtataagcc tttaagagca gagggaacca acttcagaac agttttagat     1500

aaagctgtgc aggcagatgg acaagtgaaa gaatgttacc agtctcatcg tgacaccatc     1560

gtgcttttgt gtaagccaga gcctgagctg aatgctgcca tcccttctgc taatccagca     1620

aagaccatgc agggcagtga ggttgtaaat gtcttaaaat ccttattgtc aaatcttgat     1680

gaagtaaaga aggaaagaga gggtctggag aatgacttga aatctgtgaa ttttgacatg     1740

acaagcaagt ttttgacagc cctggctcaa gatggtgtga taaatgaaga agctctttct     1800

gttactgaac tagatcgagt ctatggaggt cttacaacta aagtccaaga atctctaaag     1860

aaacaggagg gacttcttaa aaatattcag gtctcacatc aggaattttc aaaaatgaaa     1920

caatctaata atgaagctaa cttaagagaa gaagttttga agaatttagc tactgcatat     1980

gacaactttg ttgaacttgt agctaatttg aaggaaggca caaagtttta caatgagttg     2040

actgaaatcc tggtcaggtt ccagaacaaa tgcagtgata tagtttttgc acggaagaca     2100

gaaagagatg aactcttaaa ggacttgcaa caaagcattg ccagagaacc tagtgctcct     2160

tcaattccta cacctgcgta tcagtcctca ccagcaggag gacatgcacc aactcctcca     2220

actccagcgc caagaaccat gccgcctact aagccccagc ccccagccag gcctccacca     2280

cctgtgcttc cagcaaatcg agctccttct gctactgctc catctccagt gggggctggg     2340

actgctgcgc cagctccatc acaaacgcct ggctcagctc ctcctccaca ggcgcaggga     2400

ccaccctatc ccacctatcc aggatatcct gggtattgcc aaatgcccat gcccatgggc     2460

tataatcctt atgcgtatgg ccagtataat atgccatatc caccagtgta tcaccagagt     2520

cctggacagg ctccataccc gggaccccag cagccttcat accccttccc tcagccccca     2580

cagcagtctt actatccaca gcagtaa                                         2607


<210>  427
<211>  3339
<212>  DNA
<213>  Homo sapiens;

<400>  427
atgaggaggg acgagcgaga cgccaaagcc atgcggtccc tgcagccgcc ggatggggcc       60

ggctcgcccc ccgagagtct gaggaacggc tacgtgaaga gctgcgtgag ccccttgcgg      120

caggaccctc cgcgcggctt cttcttccac ctctgccgct tctgcaacgt ggagctgcgg      180

ccgccgccgg cctctcccca gcagccgcgg cgctgctccc ccttctgccg ggcgcgcctc      240

tcgctgggcg ccctggctgc ctttgtcctc gccctgctgc tgggcgcgga acccgagagc      300

tgggctgccg gggccgcctg gctgcggacg ctgctgagcg tgtgttcgca cagcttgagc      360

cccctcttca gcatcgcctg tgccttcttc ttcctcacct gcttcctcac ccggaccaag      420

cggggacccg gcccgggccg gagctgcggc tcctggtggc tgctggcgct gcccgcctgc      480

tgttacctgg gggacttctt ggtgtggcag tggtggtctt ggccttgggg ggatggcgac      540

gcagggtccg cggccccgca cacgcccccg gaggcggcag cgggcaggtt gctgctggtg      600

ctgagctgcg tagggctgct gctgacgctc gcgcacccgc tgcggctccg gcactgcgtt      660

ctggtgctgc tcctggccag cttcgtctgg tgggtctcct tcaccagcct cgggtcgctg      720

ccctccgccc tcaggccgct gctctccggc ctggtggggg gcgctggctg cctgctggcc      780

ctggggttgg atcacttctt tcaaatcagg gaagcgcctc ttcatcctcg actgtccagt      840

gccgccgaag aaaaagtgcc tgtgatccga ccccggagga ggtccagctg cgtgtcgtta      900

ggagaaactg cagccagtta ctatggcagt tgcaaaatat tcaggagacc gtcgttgcct      960

tgtatttcca gagaacagat gattctttgg gattgggact taaaacaatg gtataagcct     1020

cattatcaaa attctggagg tggaaatgga gttgatcttt cagtgctaaa tgaggctcgc     1080

aatatggtgt cagatcttct gactgatcca agccttccac cacaagtcat ttcctctcta     1140

cggagtatta gtagcttaat gggtgctttc tcaggttcct gtaggccaaa gattaatcct     1200

ctcacaccat ttcctggatt ttacccctgt tctgaaatag aggacccagc tgagaaaggg     1260

gatagaaaac ttaacaaggg actaaatagg aatagtttgc caactccaca gctgaggaga     1320

agctcaggaa cttcaggatt gctacctgtt gaacagtctt caaggtggga tcgtaataat     1380

ggcaaaagac ctcaccaaga atttggcatt tcaagtcaag gatgctatct aaatgggcct     1440

tttaattcaa atctactgac tatcccgaag caaaggtcat cttctgtatc actgactcac     1500

catgtaggtc tcagaagagc tggtgttttg tccagtctga gtcctgtgaa ttcttccaac     1560

catggaccag tgtctactgg ctctctaact aatcgatcac ccatagaatt tcctgatact     1620

gctgattttc ttaataagcc aagcgttatc ttgcagagat ctctgggcaa tgcacctaat     1680

actccagatt tttatcagca acttagaaat tctgatagca atctgtgtaa cagctgtgga     1740

catcaaatgc tgaaatatgt ttcaacatct gaatcagatg gtacagattg ctgcagtgga     1800

aaatcaggtg aagaagaaaa cattttctcg aaagaatcat tcaaacttat ggaaactcaa     1860

caagaagagg aaacagagaa gaaagacagc agaaaattat ttcaggaagg tgataagtgg     1920

ctaacagaag aggcacagag tgaacagcaa acaaatattg aacaggaagt atcactggac     1980

ctgattttag tagaagagta tgactcatta atagaaaaga tgagcaactg gaattttcca     2040

atttttgaac ttgtagaaaa gatgggagag aaatcaggaa ggattctcag tcaggttatg     2100

tataccttat ttcaagacac tggtttattg gaaatattta aaattcccac tcaacaattt     2160

atgaactatt ttcgtgcatt agaaaatggc tatcgagaca ttccttatca caatcgtata     2220

catgccacag atgtgctaca tgcagtttgg tatctgacaa cacggccagt tcctggctta     2280

cagcagatcc acaatggttg tggaacagga aatgaaacag attctgatgg tagaattaac     2340

catgggcgaa ttgcttatat ttcttcgaag agctgctcta atcctgatga gagttatggc     2400

tgcctgtctt caaacattcc tgcattagaa ttgatggctc tatacgtggc agctgccatg     2460

catgattatg atcacccagg gaggacaaat gcatttctag tggctacaaa tgcccctcag     2520

gcagttttat acaatgacag atctgttctg gaaaatcatc atgctgcgtc agcttggaat     2580

ctatatcttt ctcgcccaga atacaacttc cttcttcatc ttgatcatgt ggaattcaag     2640

cgctttcgtt ttttagtcat tgaagcaatc cttgctacgg atcttaaaaa gcattttgat     2700

tttctcgcag aattcaatgc caaggcaaat gatgtaaata gtaatggcat agaatggagt     2760

aatgaaaatg atcgcctctt ggtatgccag gtgtgcatca aactggcaga tataaatggc     2820

ccagcaaaag ttcgagactt gcatttgaaa tggacagaag gcattgtcaa tgaattttat     2880

gagcagggag atgaagaagc aaatcttggt ctgcccatca gtccattcat ggatcgttct     2940

tctcctcaac tagcaaaact ccaagaatct tttatcaccc acatagtggg tcccctgtgt     3000

aactcctatg atgctgctgg tttgctacca ggtcagtggt tagaagcaga agaggataat     3060

gatactgaaa gtggtgatga tgaagacggt gaagaattag atacagaaga tgaagaaatg     3120

gaaaacaatc taaatccaaa accaccaaga aggaaaagca gacggcgaat attttgtcag     3180

ctaatgcacc acctcactga aaaccacaag atatggaagg aaatcgtaga ggaagaagaa     3240

aaatgtaaag ctgatgggaa taaactgcag gtggagaatt cctccttacc tcaagcagat     3300

gagattcagg taattgaaga ggcagatgaa gaggaatag                            3339


<210>  428
<211>  2217
<212>  DNA
<213>  Homo sapiens;

<400>  428
atgcagccga ggtgggccca aggggccacg atgtggcttg gagtcctgct gacccttctg       60

ctctgttcaa gccttgaggg tcaagaaaac tctttcacaa tcaacagtgt tgacatgaag      120

agcctgccgg actggacggt gcaaaatggg aagaacctga ccctgcagtg cttcgcggat      180

gtcagcacca cctctcacgt caagcctcag caccagatgc tgttctataa ggatgacgtg      240

ctgttttaca acatctcctc catgaagagc acagagagtt attttattcc tgaagtccgg      300

atctatgact cagggacata taaatgtact gtgattgtga acaacaaaga gaaaaccact      360

gcagagtacc aggtgttggt ggaaggagtg cccagtccca gggtgacact ggacaagaaa      420

gaggccatcc aaggtgggat cgtgagggtc aactgttctg tcccagagga aaaggcccca      480

atacacttca caattgaaaa acttgaacta aatgaaaaaa tggtcaagct gaaaagagag      540

aagaattctc gagaccagaa ttttgtgata ctggaattcc ccgttgagga acaggaccgc      600

gttttatcct tccgatgtca agctaggatc atttctggga tccatatgca gacctcagaa      660

tctaccaaga gtgaactggt caccgtgacg gaatccttct ctacacccaa gttccacatc      720

agccccaccg gaatgatcat ggaaggagct cagctccaca ttaagtgcac cattcaagtg      780

actcacctgg cccaggagtt tccagaaatc ataattcaga aggacaaggc gattgtggcc      840

cacaacagac atggcaacaa ggctgtgtac tcagtcatgg ccatggtgga gcacagtggc      900

aactacacgt gcaaagtgga gtccagccgc atatccaagg tcagcagcat cgtggtcaac      960

ataacagaac tattttccaa gcccgaactg gaatcttcct tcacacatct ggaccaaggt     1020

gaaagactga acctgtcctg ctccatccca ggagcacctc cagccaactt caccatccag     1080

aaggaagata cgattgtgtc acagactcaa gatttcacca agatagcctc aaagtcggac     1140

agtgggacgt atatctgcac tgcaggtatt gacaaagtgg tcaagaaaag caacacagtc     1200

cagatagtcg tatgtgaaat gctctcccag cccaggattt cttatgatgc ccagtttgag     1260

gtcataaaag gacagaccat cgaagtccgt tgcgaatcga tcagtggaac tttgcctatt     1320

tcttaccaac ttttaaaaac aagtaaagtt ttggagaata gtaccaagaa ctcaaatgat     1380

cctgcggtat tcaaagacaa ccccactgaa gacgtcgaat accagtgtgt tgcagataat     1440

tgccattccc atgccaaaat gttaagtgag gttctgaggg tgaaggtgat agccccggtg     1500

gatgaggtcc agatttctat cctgtcaagt aaggtggtgg agtctggaga ggacattgtg     1560

ctgcaatgtg ctgtgaatga aggatctggt cccatcacct ataagtttta cagagaaaaa     1620

gagggcaaac ccttctatca aatgacctca aatgccaccc aggcattttg gaccaagcag     1680

aaggctagca aggaacagga gggagagtat tactgcacag ccttcaacag agccaaccac     1740

gcctccagtg tccccagaag caaaatactg acagtcagag tcattcttgc cccatggaag     1800

aaaggactta ttgcagtggt tatcatcgga gtgatcattg ctctcttgat cattgcggcc     1860

aaatgttatt ttctgaggaa agccaaggcc aagcagatgc cagtggaaat gtccaggcca     1920

gcagtaccac ttctgaactc caacaacgag aaaatgtcag atcccaatat ggaagctaac     1980

agtcattacg gtcacaatga cgatgtcaga aaccatgcaa tgaaaccaat aaatgataat     2040

aaagagcctc tgaactcaga cgtgcagtac acggaagttc aagtgtcctc agctgagtct     2100

cacaaagatc taggaaagaa ggacacagag acagtgtaca gtgaagtccg gaaagctgtc     2160

cctgatgccg tggaaagcag atactctaga acggaaggct cccttgatgg aacttag        2217


<210>  429
<211>  465
<212>  DNA
<213>  Homo sapiens;

<400>  429
atggcgcagt ctattaacat cacggagctg aatctgccgc agctagaaat gctcaagaac       60

cagctggacc aggaagtgga gttcttgtcc acgtccattg ctcagctcaa agtggtacag      120

accaagtatg tggaagccaa ggactgtctg aacgtgctga acaagagcaa cgaggggaaa      180

gaattactcg tcccactgac gagttctatg tatgtccctg ggaagctgca tgatgtggaa      240

cacgtgctca tcgatgtggg aactgggtac tatgtagaga agacagctga ggatgccaag      300

gacttcttca agaggaagat agattttcta accaagcaga tggagaaaat ccaaccagct      360

cttcaggaga agcacgccat gaaacaggcc gtcatggaaa tgatgagtca gaagattcag      420

cagctcacag ccctgggggc agctcaggct actgctaagg cctga                      465


<210>  430
<211>  1671
<212>  DNA
<213>  Homo sapiens;

<400>  430
atggcggtgg cggcggcagc tgcggcggga cccgtgttct ggaggcgact gctgggcctc       60

ctgcctggcc gcccagggct ggccgcgctc ctgggacgcc tgtccgaccg cctcggcagg      120

aaccgggacc gccagcgcag gaggtcacca tggctgttat tggctccctt gctgtcccca      180

gctgttcccc aggtcacctc cccaccttgc tgcctgtgtc cagaaggcgt gcaccggttc      240

cagtggatca gaaacctggt tccagaattt ggagtctcca gttctcacgt tagggtgctt      300

tcttccccgg cagagttttt cgagctcatg aaggggcaga taagagtagc caagaggcgg      360

gtcgtgatgg catccctcta cctggggaca ggtcctttgg aacaggagct ggtggactgc      420

ctggaaagta ctctagaaaa gtcactccaa gcaaagtttc cttcaaatct caaggtctcc      480

attctcttag acttcacgcg gggctcacga ggccggaaga actcccgcac aatgctgctc      540

ccactcctgc ggaggttccc agagcaggtc cgagtctccc tctttcacac gccgcacctc      600

cgtgggctgc ttcggctcct catccctgag cgcttcaacg agaccatcgg cctccagcac      660

attaaggtgt acctcttcga caacagcgtc atcttgagcg gtgcaaacct gagtgactcc      720

tacttcacca accgccagga ccgctacgtg ttcctgcagg actgtgcgga gattgccgac      780

ttcttcacgg agctggtgga cgcggtgggg gatgtgtccc tgcagctgca gggggacgac      840

acggtgcagg tggtggatgg gatggtgcat ccttacaaag gggaccgggc cgagtactgc      900

aaggcagcca ataagagggt catggatgtg atcaactcag ccaggacccg ccagcagatg      960

ctgcatgccc agaccttcca cagcaactct cttttgaccc aggaagatgc agcagctgct     1020

ggggatcgca gaccagcccc tgacacctgg atttatccgc tgattcagat gaagcccttc     1080

gagattcaaa tcgatgagat tgtcactgag accctgttga ctgaggcgga gcgcggggca     1140

aaggtctacc tcaccactgg ctatttcaac ctgacccagg cctacatgga cctggtcttg     1200

ggcactcggg ctgagtacca gatcctgctg gcctcaccag aggtgaatgg cttctttggg     1260

gccaaggggg tggccggcgc catcccagcg gcctatgtgc acatcgagcg acagttcttc     1320

agtgaggtgt gcagcctggg acagcaggag cgggtccagc ttcaggagta ctggcggagg     1380

ggctggacgt tccacgccaa aggcctctgg ctgtacctgg cagggagcag cctgccctgt     1440

ctcacgctga ttggctctcc taattttggg tacaggtcag ttcaccggga cctggaggcc     1500

cagattgcga tcgtgacgga gaaccaggcc ctgcagcagc agcttcacca ggagcaagag     1560

cagctctacc tgaggtcagg tgtggtgtcc tctgccacct tcgagcagcc gagtcgccag     1620

gtgaagctgt gggtgaagat ggtgactcca ctgatcaaga acttcttctg a              1671


<210>  431
<211>  972
<212>  DNA
<213>  Homo sapiens;

<400>  431
atgacctcag ggaacggaaa ctctgcctcc agcatcgccg gcactgcccc ccagaatggt       60

gagaataaac caccacaggc cattgtgaaa ccccaaatcc tgacgcatgt tatcgaaggg      120

tttgtgatcc aggagggggc ggagcctttc ccggtgggac gctcgtccct gctggtgggg      180

aatctcaaga agaagtatgc acaggggttc ctgcctgaga aacttccaca gcaggatcac      240

accaccacca ctgactcgga gatggaggag ccctatctgc aagaatccaa agaggagggt      300

gctcccctca aactcaagtg tgagctctgt ggccgggtgg actttgccta taagttcaag      360

cgttccaagc gcttctgttc catggcttgt gcaaagaggt acaacgtggg atgcaccaaa      420

cgggtgggac ttttccactc agaccggagc aagctgcaga aggcaggagc tgcgacccac      480

aaccgccgtc gggccagcaa agccagtctg ccaccactta ccaaggatac caagaagcag      540

ccaacaggca ctgtgcccct ttcggttact gctgctttgc agctaacaca cagccaggaa      600

gactccagcc gttgctcaga taactcaagc tatgaggaac ccttgtcacc catctcagcc      660

agctcatcta cttcccgccg gcgacaaggc cagcgggacc tggagctccc cgacatgcat      720

atgcgggacc tggtgggcat gggacaccac ttcctgccaa gtgagcccac caagtggaat      780

gtagaagacg tctacgaatt catccgctct ctgccaggct gccaggagat agcagaggaa      840

ttccgtgccc aggaaatcga cgggcaagcc ctgctgctgc tcaaggagga ccacctgatg      900

agcgccatga acatcaagct ggggcccgcc ctgaagatct acgcccgcat cagcatgctc      960

aaggactcct ag                                                          972


<210>  432
<211>  996
<212>  DNA
<213>  Homo sapiens;

<400>  432
atggcccagg cgtcgccgcc ccggcccgag agggtgctcg gcgccagcag cccggaggcc       60

cggcccgcgc aggaggcgct cctccttccc accggtgtct ttcaggttgc agaaaagatg      120

gaaaaaagga catgtgcact ctgccccaaa gatgtcgaat ataatgtcct atactttgca      180

caatcagaga atatagctgc tcatgagaat tgtttgctgt attcttcagg acttgtggaa      240

tgtgaggatc aggatccact taatcctgat agaagttttg atgtggaatc agtaaagaaa      300

gaaatccaga gaggaaggaa gttgaaatgc aaattttgtc ataaaagagg agccaccgtg      360

ggatgtgatt taaaaaactg taacaagaat taccactttt tctgtgccaa gaaggacgac      420

gcagttccac agtctgatgg agttcgagga atttataaac tgctttgcca gcaacatgct      480

caattcccga tcatcgctca aagtgctaaa ttttcaggag tgaaaagaaa aagaggaagg      540

aagaaacccc tctcaggcaa tcatgtacag ccacccgaaa caatgaaatg taatacattc      600

ataagacaag tgaaagaaga gcatggcaga cacacagatg caactgtgaa agttcctttt      660

cttaagaaat gcaaggaagc aggacttctt aattacttac ttgaagaaat attagacaaa      720

gttcattcaa ttccagaaaa actcatggat gagactactt cagaatcaga ctatgaagaa      780

atcgggagtg cactttttga ctgtagattg ttcgaagaca catttgtaaa ttttcaagca      840

gcaatagaga aaaaaattca tgcatctcaa caaaggtggc agcagttgaa ggaagagatt      900

gagctacttc aggacttaaa acaaaccttg tgctcttttc aagaaaatag agatcttatg      960

tcaagttcta catcaatatc atccctgtct tattag                                996


<210>  433
<211>  3291
<212>  DNA
<213>  Homo sapiens;

<400>  433
atggcgacgg tgcccgtgta ctgcgtctgc cggctcccct acgacgttac ccgcttcatg       60

atcgagtgcg acgcctgcaa ggactggttc cacggcagct gtgttggggt ggaagaggag      120

gaggcgcccg acatcgacat ataccactgc ccaaactgtg agaaaaccca tgggaagtcc      180

accttaaaga agaagcggac ctggcacaaa cacggcccgg ggcaagcgcc tgacgtcaag      240

cccgtgcaga atggcagcca gctcttcatc aaggagctgc ggagccggac ctttcccagt      300

gctgaagacg tggtggcccg tgtgccagga agtcagctca cgctgggcta catggaggag      360

cacggcttca ccgagcccat cctcgtccct aagaaagacg ggctgggtct ggctgtcccg      420

gcccccacgt tctatgtcag tgacgtcgag aactacgtgg ggccggaacg gagtgtggat      480

gtgacagatg tcaccaagca gaaggactgc aagatgaagc tgaaggagtt tgtggactat      540

tactacagca ccaaccgcaa gcgggtcctc aacgtcacca acctcgagtt ctctgacacc      600

cgaatgtcca gcttcgtgga gccacctgac attgtaaaga aactgtcatg ggtagaaaac      660

tactggccag atgatgcatt gctggccaag cccaaagtga ccaagtactg cctaatctgc      720

gtgaaggaca gttacaccga cttccacatc gactctgggg gcgcctctgc ctggtaccac      780

gtgctcaagg gggagaagac cttctatctc atcaggccgg cctcggccaa catctccctg      840

tatgagcgct ggcggtctgc ctctaaccac agcgagatgt tctttgctga ccaggtcgac      900

aaatgctaca agtgcatcgt caagcagggc cagaccctct tcatcccctc aggctggatc      960

tacgccacac tcacccctgt ggactgcctg gccttcgcgg gacatttcct ccacagcctg     1020

agtgtggaga tgcagatgag agcatatgaa gtggaaagga ggttgaaact gggcagcctg     1080

actcagtttc ccaactttga aactgcgtgc tggtacatgg ggaagcacct gctggaggca     1140

ttcaaaggct ctcacaaatc tgggaagcag ctgccccctc atctagtcca aggagctaaa     1200

attctcaatg gtgctttccg atcgtggacg aagaagcagg ctttggcaga gcatgaggac     1260

gagctcccgg agcacttcaa accttcacag ctaatcaaag acctggccaa agagatccgg     1320

ctcagtgaga atgcctccaa agccgtccga ccggaagtga atactgtcgc ctcgtcagat     1380

gaggtgtgtg acggggaccg ggagaaggag gagcccccgt ctcccattga ggccaccccg     1440

cctcaatccc tcctggagaa agtgtccaaa aaaaagactc ccaaaactgt gaagatgccc     1500

aagccatcca aaatccccaa gcccccgaag ccccctaagc ccccaaggcc ccccaaaacg     1560

ctgaagctca aagatggagg caagaagaaa gggaagaagt cccgggagtc agcctcaccc     1620

accatcccca acctggacct gctcgaagcc cacaccaagg aggcactgac caagatggag     1680

ccgcccaaga agggcaaggc cacaaagagt gtcctgagtg tgcccaacaa agatgtggtt     1740

cacatgcaga atgatgtgga gaggctggaa attcgagagc aaaccaagag caagtcagag     1800

gccaagtgga agtacaagaa cagcaaacct gactccttac tgaagatgga agaggagcag     1860

aagctagaga agtcgcctct agctggaaac aaagacaata agttctcttt ttctttctcc     1920

aacaagaaac tcctcggctc caaggctctc aggcccccga cgagccctgg tgtgttcggg     1980

gccttgcaga acttcaagga ggacaagccc aagcccgtgc gggatgagta tgagtacgtg     2040

tcggatgacg gtgagctcaa gatcgacgag tttcccatca ggaggaagaa aaacgccccg     2100

aaaagggact tgtccttctt gttggataag aaggctgtgc tgcccacgcc tgtcacgaag     2160

ccaaagctgg actcggcagc gtacaagagt gatgactcct cggacgaggg ttcgctgcac     2220

atcgacacag acaccaagcc cggccgcaat gccagagtca agaaggagag tgggagctcg     2280

gcagctggca tcttggacct gctgcaggcc agtgaggagg ttggcgcgct ggagtacaac     2340

cccagcagcc agcccccggc ctcccccagc acacaggaag ccattcaggg aatgctgtcc     2400

atggccaacc tgcaggcctc cgactcctgc ctgcagacca cgtggggagc tggccaggcc     2460

aaggggagct cgctggctgc ccatggtgcc cggaagaatg ggggtggcag tggcaagagt     2520

gcaggcaaac gactgctgaa gagggctgcc aagaacagtg tcgacctgga cgactacgag     2580

gaagagcagg accacctgga tgcctgcttc aaggactcag actacgttta cccctcactg     2640

gagtcagatg aagacaaccc catctttaag tcccggtcga agaaaaggaa aggctcagac     2700

gacgctccct acagcccaac agcaagggtc ggcccatcgg tgccaagaca ggacaggcct     2760

gtgcgtgagg gtacacgggt ggcttccatc gagaccgggc tggcggctgc tgcagctaag     2820

ttgtcccagc aggaggagca gaaaagcaag aaaaaaaaga gtgccaagag gaagctgact     2880

cctaacacca cctccccttc cacctccacc tccatctctg ccggcaccac ctccacctcc     2940

accacgccag cctctaccac cccggcctcc accaccccgg cctccaccag cacggccagc     3000

agccaggcct cgcaggaggg cagctcgcca gagcccccgc ctgagtcgca tagcagcagc     3060

ctggcggacc atgagtacac agccgctggc accttcaccg gggcccaggc tggccgcacc     3120

tcccagccca tggcccctgg ggtctttctc acacagaggc ggccctccgc atcgtctcca     3180

aacaacaaca ccgctgccaa aggaaaacgt acgaaaaagg gcatggcgac cgccaagcag     3240

aggcttggga aaattttgaa aattcatcgg aacgggaaac tactccttta a              3291


<210>  434
<211>  3039
<212>  DNA
<213>  Homo sapiens;

<400>  434
atgacaaagc atccacctaa cagacgagga atcagctttg aagtgggagc ccagttggaa       60

gcccgggacc gtttaaaaaa ctggtatcca gctcacatag aagacattga ctacgaggaa      120

ggaaaagtac tcatccattt caagcgttgg aaccatcgtt atgatgagtg gttctgctgg      180

gacagtcctt atttacgccc tttagagaaa atacagctga ggaaagaggg cttgcatgaa      240

gaggatggat cttctgaatt tcaaataaat gagcaggtcc ttgcttgctg gtctgattgt      300

cgtttttacc cggccaaagt cactgctgtt aacaaggatg gtacttacac tgtgaaattt      360

tatgatggag tagttcagac tgtcaaacat attcatgtca aagctttttc caaagatcag      420

aatattgtgg gtaatgctag gcctaaagaa acagatcaca aaagtctttc atcatctcct      480

gataaacgag agaagtttaa agaacagaga aaagcaacag tgaatgtgaa gaaagacaaa      540

gaagataaac ccttaaagac agaaaagcga cccaagcagc ctgataaaga aggaaagtta      600

atctgttctg aaaaggggaa agtgtcagag aaaagtcttc ccaagaacga gaaggaagac      660

aaggaaaaca tttccgaaaa tgacagagag tattctggag atgcccaagt ggataagaaa      720

cctgaaaatg acattgtgaa gagtccacaa gaaaacttga gggaacccaa aagaaaacga      780

ggcagacccc cttccatagc tcctactgct gtggattcaa actctcaaac tttgcaacca      840

ataacattgg aactgagaag aaggaaaata tcaaaaggat gtgaagtccc attaaaacgt      900

cctcggcttg acaaaaattc atcccaggaa aagtcaaaaa actactcgga aaacactgac      960

aaagacttat cgaggagacg ttcctccagg ctgtccacta atgggaccca tgagatccta     1020

gatcctgact tggttgtatc agatttggtt gatacggatc ctttgcaaga cacgttgtct     1080

agtaccaagg aatctgaaga aggtcagttg aagtctgctt tggaagctgg ccaggtctca     1140

tctgcactga cttgccactc ctttggggat ggatccgggg ctgcaggctt ggagttgaac     1200

tgcccatcaa tgggagaaaa cacgatgaaa acagaaccga cttctcccct tgtggaatta     1260

caagagattt cgactgtgga agtaacaaat acttttaaga aaacagatga ttttgggtca     1320

tctaatgcac cagctgtcga cctagaccat aagtttagat gcaaagttgt ggactgttta     1380

aaatttttcc gcaaagccaa actgttgcac tatcacatga agtatttcca tggaatggag     1440

aagtcactgg agccagaaga gagcccggga aagaggcatg tccaaaccag gggcccttca     1500

gcttcagaca agcccagcca ggagaccctg accaggaagc gggtctctgc cagttcccca     1560

actacaaaag acaaggaaaa gaataaagag aagaaattca aggagtttgt gagagtgaag     1620

ccaaagaaga aaaagaaaaa gaaaaagaaa accaaacctg aatgcccctg cagtgaggag     1680

atcagtgaca cctcccagga accttctcca cccaaggcat ttgctgttac caggtgtggg     1740

tcctcacaca agccaggggt ccatatgagc ccgcagcttc atggcccaga atctggacac     1800

cacaaaggga aagtgaaagc attggaggag gataatttga gtgagtcctc ttctgagagc     1860

tttctctgga gtgatgatga gtatggccaa gatgtggatg tgaccaccaa cccagatgag     1920

gaacttgatg gggatgaccg ctatgacttc gaggtggtcc gctgcatctg tgaggtccag     1980

gaggaaaatg acttcatgat tcagtgtgaa gagtgccagt gctggcagca tggggtctgc     2040

atgggattac tggaagaaaa tgtgcccgag aaatacacct gttatgtttg ccaagaccct     2100

ccaggtcaga ggcctggctt caagtactgg tatgacaagg agtggctgag caggggacat     2160

atgcatggcc tggcatttct agaagagaac tactcccatc agaatgccaa gaagatcgtg     2220

gccacccacc agcttcttgg tgatgtgcag agagtgattg aggttctgca tggcctgcag     2280

ctcaagatga gcatcttgca aagccgggag catcctgatc tgccgctgtg gtgccagcct     2340

tggaaacagc actcagggga ggggagatct catttcagaa acatccctgt cactgacacc     2400

aggagcaagg aggaagctcc aagctataga actttgaacg gggcagtgga gaagcccagg     2460

cccctggccc tgcccctgcc gcgttctgtg gaggaatcct atatcaccag tgagcattgc     2520

taccagaagc cccgcgccta ttaccctgcc gtggagcaga agctggtggt ggagacgagg     2580

ggctctgccc tcgacgatgc ggtcaacccc ctccatgaga acggcgatga ttccctttcc     2640

ccgcgcctgg gctggcctct agaccaagac aggagcaagg gggacagtga ccccaaaccc     2700

ggctccccaa aggtgaagga atatgtctcc aaaaaggccc taccagaaga agcccctgct     2760

cggaagctgc tggacagagg tggagagggg ctgctgagct cccagcacca gtggcagttt     2820

aacctgctga cccatgtgga atctcttcag gatgaagtta cgcacaggat ggactccatt     2880

gagaaggagt tggatgtgtt ggagagctgg ctggactaca ctggggaact ggagccccct     2940

gagccgctgg ccaggcttcc gcagctcaag cattgtatca agcagctgct gatggacctg     3000

ggcaaggtgc agcagatcgc cctctgctgc tcaacatga                            3039


<210>  435
<211>  3054
<212>  DNA
<213>  Homo sapiens;

<400>  435
atgagtaaaa agcccccaaa tcgccctgga atcacttttg agattggtgc tcgtttggag       60

gcactggact acttacaaaa atggtatcca tcacgaattg aaaaaattga ctatgaggag      120

ggcaagatgt tggtccattt tgagcgctgg agtcatcgtt atgatgagtg gatttactgg      180

gatagcaata gattgcgacc ccttgagaga ccagcactaa gaaaagaagg gctaaaagat      240

gaggaagatt tctttgattt taaagctgga gaagaagttc tggctcgttg gacagactgt      300

cgctattacc ctgccaagat tgaagcaatt aacaaagaag gaacatttac agttcagttt      360

tatgatggag taattcgttg tttaaaaaga atgcacatta aagccatgcc cgaggatgct      420

aaggggcagg tgaaatccca gcatccacta agctggtgtt gtcctatcga cccagctgga      480

tcgtgtaacc agtctatggg aagtgaggat tggatagctt tagtcaaagc agctgctgca      540

gctgcagcca agaacaaaac agggagtaaa cctcgaacca gcgctaacag caataaagat      600

aaggataaag atgagagaaa gtggtttaaa gtaccttcaa agaaggagga aacttcaact      660

tgtatagcca caccagacgt agagaagaag gaagatctgc ctacatctag tgaaacattt      720

ggacttcatg tagagaacgt tccaaagatg gtctttccac agccagagag cacattatca      780

aacaagagga aaaataatca aggcaactcg tttcaggcaa agagagctcg acttaacaag      840

attactggtt tgttggcatc caaagctgtt ggggttgatg gtgctgaaaa aaaggaagac      900

tacaatgaaa cagctccaat gctggagcag gcgatttcac ctaaacctca aagtcagaaa      960

aaaaatgaag ctgacattag cagttctgcc aacactcaga aacctgcact gttatcctca     1020

actttgtctt cagggaaggc tcgcagcaag aaatgcaaac atgaatctgg agattcttct     1080

gggtgtataa aaccccctaa atcaccactt tccccagaat taatacaagt cgaggatttg     1140

acgcttgtat ctcagctttc ttcttcagtg ataaataaaa ctagtcctcc acagcctgtg     1200

aatcccccta gacctttcaa gcatagtgag cggagaagaa gatctcagcg tttagccacc     1260

ttacccatgc ctgatgattc tgtagaaaag gtttcttctc cctctccagc cactgatggg     1320

aaagtattct ccatcagttc tcaaaatcag caagaatctt cagtaccaga ggtgcctgat     1380

gttgcacatt tgccacttga gaagctggga ccctgtctcc ctcttgactt aagtcgtggt     1440

tcagaagtta cagcaccggt agcctcagat tcctcttacc gtaatgaatg tcccagggca     1500

gaaaaagagg atacacagat gcttccaaat ccttcttcca aagcaatagc tgatggaaga     1560

ggagctccag cagcagcagg aatatcgaaa acagaaaaaa aagtgaaatt ggaagacaaa     1620

agctcaacag catttggtaa gagaaaagaa aaagataagg aaagaagaga gaagagagac     1680

aaagatcact acagaccaaa acagaagaag aagaaaaaaa agaaaaagaa atctaagcaa     1740

catgactatt cagactatga agacagttcc ctcgaatttt tggaaaggtg ctcttctcca     1800

ctaactcgat cttctgggag ttctctggct tcacgaagca tgtttacgga gaaaactaca     1860

acctatcagt acccaagggc aattctatcc gttgatctta gtggtgaaaa cttatcagat     1920

gtagacttcc tagatgattc ttcaacggag agtttgcttc tgagtgggga tgaatacaat     1980

caggactttg attcaaccaa ttttgaggaa tctcaggatg aggatgatgc tcttaatgaa     2040

attgtgcgat gtatttgtga gatggatgag gagaatggct tcatgatcca gtgtgaagag     2100

tgcttgtgtt ggcaacacag cgtgtgcatg gggctgctgg aggagagcat tccagagcag     2160

tacatctgct atatctgccg ggacccacca ggtcagaggt ggagtgcaaa atatcgttat     2220

gataaggagt ggttgaataa tgggagaatg tgcgggttat catttttcaa agaaaattat     2280

tctcatctca atgccaaaaa gatagtttct acacatcacc tgcttgctga tgtctatggt     2340

gttacagaag tgctacacgg gctacagctg aagattggaa tactaaagaa taaacatcat     2400

cctgaccttc atctctgggc ttgttccggg aagcgaaaag accaagatca aataatagct     2460

ggggtggaga aaaaaatagc tcaagacaca gttaatcgag aagaaaagaa atatgtacag     2520

aaccataaag aaccacctcg tttgccccta aaaatggaag gaacttatat aacaagtgag     2580

catagctatc aaaagccaca aagttttggt caggactgta aatctctcgc agaccctggg     2640

agctcagatg atgatgatgt tagtagtttg gaagaagaac aagaattcca catgagaagt     2700

aaaaacagtt tacagtactc agcaaaagaa catggaatgc ctgaaaagaa tccagctgaa     2760

gggaatacag tatttgttta taatgataaa aagggcaccg aagacccagg agactcacat     2820

cttcagtggc agctcaatct ccttacacac atagaaaatg tgcagaacga agttaccagc     2880

aggatggacc taatagaaaa agaagtcgat gttctggaaa gctggcttga tttcacaggg     2940

gagttggagc caccagatcc tcttgcaaga ttgccccaac ttaaacgcca cataaaacag     3000

ctcctaattg acatgggcaa agtacagcag atagcaactc tttgctctgt atga           3054


<210>  436
<211>  6120
<212>  DNA
<213>  Homo sapiens;

<400>  436
atggatatag ttgatacatt taatcattta attcctactg aacacttaga tgatgcccta       60

tttctaggat ccaacctgga gaatgaagtc tgtgaggatt ttagtgcaag tcaaaatgtc      120

ttagaggact cgctgaagaa catgctcagc gataaggatc ctatgctagg atctgcaagt      180

aaccagttct gtttgcctgt tttggatagc aatgatccca atttccagat gccttgttca      240

acagttgttg gtcttgacga tattatggat gaaggagttg ttaaagaaag tggcaatgat      300

accattgatg aagaagaact gattttacct aacaggaact taagggacaa ggtagaagaa      360

aattcagtga gatctccaag aaaatcacct cgtttaatgg cacaagaaca agtaagaagt      420

ttgcgacaga gcactattgc caagcgttca aatgcagcac cattaagtaa cacaaaaaaa      480

gcatctggga agactgtatc tactgctaaa gcaggagtga aacaaccaga aaggagtcag      540

gttaaagaag aagtatgtat gtcactgaaa cctgagtacc ataaggagaa tagaaggtgc      600

agccgaaata gcggacaaat tgaagtggta cctgaagtat cagtgtcttc aagtcattct      660

tcagtgtcat cttgtcttga aatgaaggat gaagatggat tagattctaa gcataagtgt      720

aataatccgg gagaaataga tgtgccatct catgaattaa attgttcact tctttcagag      780

acttgtgtta ctattggaga aaagaaaaat gaagctttga tggaatgtaa agccaagcct      840

gttggtagtc cattgtttaa gttttcagat aaagaagaac atgaacaaaa tgattccatt      900

tcaggtaaaa cgggtgagac tgttgttgaa gaaatgatag caacaagaaa agttgaacaa      960

gattcaaagg agacagtaaa attatcccat gaagatgacc atattcttga ggacgctgga     1020

tcttctgata tttctagtga tgctgcttgt acaaatccaa ataagacaga aaacagcctt     1080

gtaggtttgc ctagttgtgt agatgaagtg actgaatgta atttggaatt gaaggatacc     1140

atgggtattg ctgataaaac tgagaacacc cttgaaagaa ataaaattga accgttgggt     1200

tattgtgaag atgcggagtc taataggcag ttggagagca ctgagtttaa taaatcaaac     1260

ttagaggtgg ttgatactag tacttttgga ccggaaagta atatcttgga aaatgctatt     1320

tgtgatgtgc ctgaccaaaa ttcaaaacag ttgaatgcta tagaaagtac taaaatagag     1380

tcccatgaaa cagcaaacct tcaggatgac agaaacagcc agtcaagtag cgtttcttac     1440

ttagagtcaa aaagtgtaaa atccaaacat acaaaacctg taattcattc taagcaaaac     1500

atgaccacag atgctccgaa gaaaattgtt gcagcaaagt atgaagtaat acatagcaaa     1560

actaaagtta atgtcaaaag tgtgaaacga aatactgatg taccagaatc tcagcaaaat     1620

tttcataggc cagtcaaagt cagaaaaaaa caaattgata aggagccaaa gattcagagt     1680

tgcaattctg gggttaaatc tgtgaaaaac caagctcatt ctgtactgaa aaaaacatta     1740

caggatcaaa ctttagtaca aattttcaag cccttaactc attctttgag tgataagtca     1800

cacgctcatc ctggttgctt gaaagaacct catcatcctg cacaaactgg acatgtatca     1860

cattctagcc agaaacagtg tcataagcct cagcaacagg ccccagcaat gaaaaccaat     1920

agtcacgtga aggaagagct tgaacaccca ggcgttgagc attttaagga agaggataaa     1980

ctgaaactga aaaaacctga gaagaaccta caaccccgcc aaagaagaag cagcaaaagt     2040

ttttctttag atgagccacc attgttcatt ccagataaca tagctaccat aagaagagaa     2100

ggctctgatc atagctcctc atttgaaagc aaatatatgt ggactcccag caagcagtgt     2160

gggttttgca aaaaaccaca tggcaacagg tttatggttg gctgtgggag atgtgatgac     2220

tggtttcatg gtgattgtgt tgggttaagt ctttctcaag cacagcagat gggcgaggaa     2280

gacaaagaat atgtctgtgt aaaatgttgt gctgaagaag acaaaaagac tgaaatacta     2340

gatccagata ctttggaaaa ccaagctaca gttgaattcc atagtggaga taaaacaatg     2400

gagtgtgaaa agcttggatt atcaaaacac acaacaaatg atagaaccaa atatatagat     2460

gatacagtga agcacaaggt caaaatttta aaacgggagt ctggtgaagg cagaaattca     2520

tcagactgta gagataatga aattaaaaaa tggcagctag ctcctcttcg taagatggga     2580

caaccagttt tacctcggag atcctcagaa gaaaaaagtg aaaaaatacc gaaagagtct     2640

acaactgtta cttgcacagg agaaaaagct tcaaaaccag gtactcatga gaagcaagag     2700

atgaaaaaga agaaagttga aaaaggagtg cttaatgtac atcctgctgc ttctgcttcc     2760

aagccttctg cagatcagat caggcaaagt gtcagacatt ctctcaaaga cattcttatg     2820

aagagactta cagactcaaa tttgaaggta ccagaggaaa aggcagcaaa agttgccaca     2880

aaaattgaga aagagctttt ctcttttttt cgggacacag atgctaaata taagaacaaa     2940

tatagaagtt tgatgtttaa tttgaaagat cctaaaaaca atatattatt taaaaaagta     3000

ctgaaaggag aagtaactcc tgatcatctt atcagaatga gtccagaaga actagcttct     3060

aaagagttag ctgcttggag acgaagagaa aacagacata ccatagaaat gattgagaaa     3120

gagcagagag aagtggaacg acggccaatc accaaaataa ctcataaagg tgaaatagaa     3180

attgagagtg atgccccaat gaaagaacag gaagcagcca tggagattca ggaaccagcc     3240

gccaataagt cattggagaa gccagaagga tctgaaaaac aaaaagagga ggttgactct     3300

atgtctaaag ataccactag tcaacacaga cagcatcttt ttgatctcaa ctgcaaaatc     3360

tgcataggtc gaatggcacc acctgtagat gatctttctc caaaaaaagt aaaagttgtt     3420

gtaggagtag ctcgcaaaca ttcagacaat gaagcagaaa gtatagcaga tgcattatct     3480

tcaacctcaa atattttggc ttctgaattc tttgaggagg agaaacagga gtctccaaag     3540

tcaacgttct ctcctgctcc acgtccagag atgcctggaa ctgttgaagt tgagtctacc     3600

tttctggctc gattgaactt catctggaaa ggttttatca acatgccttc tgtggcaaaa     3660

tttgttacca aagcctatcc agtatctggc tccccagaat acctgacaga ggacctacca     3720

gatagtattc aagtaggtgg caggatatca cctcagacag tttgggatta tgtggaaaaa     3780

ataaaagcat caggaaccaa ggaaatttgt gtggttcgct tcacaccagt aactgaagaa     3840

gatcaaattt cttatacttt gctctttgca tacttcagta gcagaaagcg ctatggagta     3900

gctgctaaca acatgaagca ggttaaagat atgtacctta ttcctttggg tgccacagat     3960

aaaattccac accctcttgt gccttttgat ggacctgggc ttgaactgca tagacctaat     4020

ctattgttgg gcttaattat tcgtcagaaa ctgaagcgac agcacagtgc ctgtgctagt     4080

actagtcata tagctgagac tcctgaaagt gcaccaccaa tagcattgcc acctgataaa     4140

aaaagtaaaa tagaagtttc tacagaagaa gcaccagagg aagaaaatga cttttttaat     4200

tcttttacaa ctgtattaca caagcagaga aataaacctc agcagaatct tcaggaagac     4260

cttccaacag cagttgaacc tttaatggaa gtcaccaaac aggagccacc aaaaccttta     4320

agatttcttc ctggcgtgtt gattggctgg gagaatcaac ctactactct ggaattagca     4380

aataaacctc ttcctgtgga tgatatactt caaagccttt tgggcaccac tggtcaagta     4440

tatgaccagg cccagtcagt gatggaacaa aacactgtta aagaaattcc atttttaaat     4500

gagcagacca actcaaaaat agagaaaaca gataatgtgg aagtaactga tggtgaaaac     4560

aaggagataa aagttaaagt agataatatt tcagaatcta cagataagtc agcagaaata     4620

gaaacatcag tagtagggtc ctcttccatt tctgcagggt ctttgacgag tcttagtctc     4680

agaggtaagc caccagatgt ttctacagaa gcatttttaa caaatttatc aattcagtca     4740

aaacaagagg aaactgtgga gagtaaagag aaaacattaa aaagacagct tcaggaagat     4800

caagagaata atttgcaaga taaccagact tcaaatagtt ctccatgcag atctaatgta     4860

ggaaaaggaa acatagatgg taatgtgagc tgtagtgaaa accttgttgc taatacagcg     4920

aggtctccac agtttatcaa cctgaaaagg gatcctaggc aagcagcagg acgaagtcag     4980

cctgtaacta cttcagaaag caaagatgga gatagttgcc ggaatggaga aaaacacatg     5040

ctgcctggcc tgtcacacaa caaggagcac ttaacagaac aaatcaatgt agaggaaaag     5100

ttgtgttctg cagagaaaaa ctcgtgtgtt cagcagagtg acaatttaaa agttgcacaa     5160

aactcaccat cagtagaaaa catacagact tctcaagcag aacaagcaaa acccttacag     5220

gaggatattt taatgcaaaa tattgaaact gtgcacccat ttcgaagagg atcagcagta     5280

gcgacatctc attttgaagt tggaaacaca tgtccatcag aatttccttc taaaagcatc     5340

acctttactt ccagaagcac cagccccaga acaagtacaa acttttcacc catgaggcca     5400

cagcagccca accttcagca tctcaagtct agcccacctg gatttccatt tccagggcct     5460

cctaattttc ccccacaaag catgtttgga tttccaccac atttgccacc tccattactt     5520

ccccctccag gctttggctt tgctcaaaat cccatggttc cctggccacc tgttgttcat     5580

ctcccaggtc agccacagcg tatgatgggt cctctctcac aagcatcaag gtatataggc     5640

ccgcagaatt tttaccaggt taaagacatt cggaggccag aaaggcgcca tagtgaccct     5700

tggggtaggc aagaccaaca gcaactggat aggccattta ataggggtaa aggggaccgc     5760

cagagatttt atagtgattc acaccatttg aaaagagagc gacatgaaaa ggaatgggag     5820

caagaatctg aaaggcatag acgcagagac agaagccaag acaaggacag agacagaaaa     5880

agcagggagg aagggcacaa agataaagag agggcacggt tatcacatgg tgatcgagga     5940

acagatggaa aagcaagcag agatagtagg aatgtagaca agaagccaga taaacctaaa     6000

agtgaagact atgagaagga caaagaacga gagaaaagta aacacagaga aggagaaaag     6060

gacagggata ggtaccacaa agatagggac cacactgaca gaactaaaag caaaaggtaa     6120


<210>  437
<211>  1956
<212>  DNA
<213>  Homo sapiens;

<400>  437
atggcggaca gtgcggaact aaagcaaatg gttatgagcc ttagagtttc tgaactccaa       60

gtactgttgg gctacgccgg gagaaacaag cacggacgca aacacgaact tctcacaaaa      120

gccctgcatt tgctaaaggc tggctgtagt cctgctgtgc aaatgaaaat taaggaactc      180

tataggcggc ggttcccaca gaaaatcatg acgcctgcag acttgtccat ccccaacgta      240

cattcaagtc ctatgccagc aactttgtct ccatctacca ttccacaact cacttacgat      300

ggtcaccctg catcatcgcc attactccct gtttctcttc tgggacctaa acatgaactg      360

gaactcccac atcttacatc agctcttcac ccagtccatc cggatataaa acttcaaaaa      420

ttaccatttt atgatttact ggatgaactg ataaaaccca ccagtctagc atcagacaac      480

agtcagcgct ttcgagaaac ctgttttgca tttgccttga caccacaaca agtgcagcaa      540

atcagtagtt ccatggatat ttctgggacc aaatgtgact tcacagtaca ggtccagtta      600

aggttttgtt tatcagaaac cagttgtcca caagaagatc acttcccacc caatctttgt      660

gtgaaagtga atacaaaacc ttgcagcctt ccaggttacc ttccacctac aaaaaatggc      720

gtggaaccaa agcgacccag ccgaccaatt aatatcacct cacttgtccg actgtccaca      780

acagtaccaa acacgattgt tgtttcttgg actgcagaaa ttggaagaaa ctattccatg      840

gcagtatatc ttgtaaaaca gttgtcctca acagttcttc ttcagaggtt acgagcaaag      900

ggaataagga atccggatca ttctagagct ttaattaaag agaagttgac tgcggatcca      960

gacagtgaaa tagctacaac cagcctaagg gtttctctac tatgtccact tggtaaaatg     1020

cggctgacaa ttccgtgtcg ggcccttaca tgttctcatc tacaatgttt tgacgcaact     1080

ctttacattc agatgaatga gaaaaaacca acctgggttt gtcctgtctg tgataagaag     1140

gctccatatg aacaccttat tattgatggc ttgtttatgg aaatcctaaa gtactgtaca     1200

gactgtgatg aaatacaatt taaggaggat ggcacttggg caccgatgag atcaaaaaag     1260

gaagtacagg aagtttctgc ctcttacaat ggagtcgatg gatgcttgag ctccacattg     1320

gagcatcagg tagcgtctca ccaccagtcc tcaaataaaa acaagaaagt agaagtgatt     1380

gacctaacca tagacagttc atctgatgaa gaggaagaag agccatctgc caagaggacc     1440

tgtccttccc tatctcccac atcaccacta aataataaag gcattttaag tcttccacat     1500

caagcatctc cagtatcccg caccccaagc cttcctgctg tagacacaag ctacattaat     1560

acctccctca tccaagacta taggcatcct ttccacatga cacccatgcc ttacgactta     1620

caaggattag atttctttcc tttcttatca ggagacaatc agcattacaa cacctccttg     1680

cttgccgctg cagcagcagc agtttcagat gatcaagacc tcctacactc gtctcggttt     1740

ttcccgtata cctcctcaca gatgtttctt gatcagttaa gtgcaggagg cagtacttct     1800

ctgccaacca ccaatggaag cagtagtggc agtaacagca gcctggtttc ttccaacagc     1860

ctaagggaaa gccatagcca caccgtcaca aacaggagca gcacggacac ggcatccatc     1920

tttggcatca taccagacat tatttcattg gactga                               1956


<210>  438
<211>  792
<212>  DNA
<213>  Homo sapiens;

<400>  438
atgctgttgg cctgggtaca agcattcctc gtcagcaaca tgctcctagc agaagcctat       60

ggatctggag gctgtttctg ggacaacggc cacctgtacc gggaggacca gacctccccc      120

gcgccgggcc tccgctgcct caactggctg gacgcgcaga gcgggctggc ctcggccccc      180

gtgtcggggg ccggcaatca cagttactgc cgaaacccgg acgaggaccc gcgcgggccc      240

tggtgctacg tcagtggcga ggccggcgtc cctgagaaac ggccttgcga ggacctgcgc      300

tgtccagaga ccacctccca ggccctgcca gccttcacga cagaaatcca ggaagcgtct      360

gaagggccag gtgcagatga ggtgcaggtg ttcgctcctg ccaacgccct gcccgctcgg      420

agtgaggcgg cagctgtgca gccagtgatt gggatcagcc agcgggtgcg gatgaactcc      480

aaggagaaaa aggacctggg aactctgggc tacgtgctgg gcattaccat gatggtgatc      540

atcattgcca tcggagctgg catcatcttg ggctactcct acaagagggg gaaggatttg      600

aaagaacagc atgatcagaa agtatgtgag agggagatgc agcgaatcac tctgcccttg      660

tctgccttca ccaaccccac ctgtgagatt gtggatgaga agactgtcgt ggtccacacc      720

agccagactc cagttgaccc tcaggagggc accacccccc ttatgggcca ggccgggact      780

cctggggcct ga                                                          792


<210>  439
<211>  1746
<212>  DNA
<213>  Homo sapiens;

<400>  439
atggcggtgc gacaggcgct gggccgcggc ctgcagctgg gtcgagcgct gctgctgcgc       60

ttcacgggca agcccggccg ggcctacggc ttggggcggc cgggcccggc ggcgggctgt      120

gtccgcgggg agcgtccagg ctgggccgca ggaccgggcg cggagcctcg cagggtcggg      180

ctcgggctcc ctaaccgtct ccgcttcttc cgccagtcgg tggccgggct ggcggcgcgg      240

ttgcagcggc agttcgtggt gcgggcctgg ggctgcgcgg gcccttgcgg ccgggcagtc      300

tttctggcct tcgggctagg gctgggcctc atcgaggaaa aacaggcgga gagccggcgg      360

gcggtctcgg cctgtcagga gatccaggca atttttaccc agaaaagcaa gccggggcct      420

gacccgttgg acacgagacg cttgcagggc tttcggctgg aggagtatct gatagggcag      480

tccattggta agggctgcag tgctgctgtg tatgaagcca ccatgcctac attgccccag      540

aacctggagg tgacaaagag caccgggttg cttccaggga gaggcccagg taccagtgca      600

ccaggagaag ggcaggagcg agctccgggg gcccctgcct tccccttggc catcaagatg      660

atgtggaaca tctcggcagg ttcctccagc gaagccatct tgaacacaat gagccaggag      720

ctggtcccag cgagccgagt ggccttggct ggggagtatg gagcagtcac ttacagaaaa      780

tccaagagag gtcccaagca actagcccct caccccaaca tcatccgggt tctccgcgcc      840

ttcacctctt ccgtgccgct gctgccaggg gccctggtcg actaccctga tgtgctgccc      900

tcacgcctcc accctgaagg cctgggccat ggccggacgc tgttcctcgt tatgaagaac      960

tatccctgta ccctgcgcca gtacctttgt gtgaacacac ccagcccccg cctcgccgcc     1020

atgatgctgc tgcagctgct ggaaggcgtg gaccatctgg ttcaacaggg catcgcgcac     1080

agagacctga aatccgacaa catccttgtg gagctggacc cagacggctg cccctggctg     1140

gtgatcgcag attttggctg ctgcctggct gatgagagca tcggcctgca gttgcccttc     1200

agcagctggt acgtggatcg gggcggaaac ggctgtctga tggccccaga ggtgtccacg     1260

gcccgtcctg gccccagggc agtgattgac tacagcaagg ctgatgcctg ggcagtggga     1320

gccatcgcct atgaaatctt cgggcttgtc aatcccttct acggccaggg caaggcccac     1380

cttgaaagcc gcagctacca agaggctcag ctacctgcac tgcccgagtc agtgcctcca     1440

gacgtgagac agttggtgag ggcactgctc cagcgagagg ccagcaagag accatctgcc     1500

cgagtagccg caaatgtgct tcatctaagc ctctggggtg aacatattct agccctgaag     1560

aatctgaagt tagacaagat ggttggctgg ctcctccaac aatcggccgc cactttgttg     1620

gccaacaggc tcacagagaa gtgttgtgtg gaaacaaaaa tgaagatgct ctttctggct     1680

aacctggagt gtgaaacgct ctgccaggca gccctcctcc tctgctcatg gagggcagcc     1740

ctgtga                                                                1746


<210>  440
<211>  1128
<212>  DNA
<213>  Homo sapiens;

<400>  440
atgatgtgtc agtcagaggc gcggcaagga ccagagctcc gcgcggcgaa atggttgcac       60

ttcccccagc tggccctgag gcggaggctg gggcagctga gctgcatgtc cagacccgct      120

ctgaaactgc gctcctggcc cttgaccgtc ctctactacc tcctgccctt cggcgccctc      180

agaccgctca gccgggtggg atggaggccc gtaagcaggg tggctttgta caagtcagtg      240

ccaacgcgct tgctgtcacg ggcctggggt cgcctcaatc aggtggagct gccacactgg      300

ctgcgcaggc ccgtctacag cctgtacatc tggacgtttg gggtgaacat gaaagaggcc      360

gctgtggagg acctgcatca ctaccgcaac ctcagcgagt tcttccggcg caagctgaag      420

ccgcaggccc ggcctgtctg tggcctgcac agcgtgatta gcccatcgga tggaaggatc      480

ctcaactttg ggcaggtgaa gaactgtgag gtggagcagg taaagggggt cacctactcc      540

ctggagtcgt tcctgggccc gcgtatgtgc acagaggacc tgcccttccc accagccgcg      600

tcgtgtgact ccttcaagaa ccagctggtc acccgggaag ggaatgagct ctatcactgt      660

gtcatctacc tggcccctgg ggactaccac tgcttccact cccccaccga ctggactgtg      720

tcccaccggc gccacttccc aggctccctg atgtcagtga accctggcat ggctcgctgg      780

atcaaagagc tcttctgcca taacgagcgg gtggtcctga cgggggactg gaaacatggc      840

ttcttctcac tgacagctgt gggggccacc aacgtgggct ccattcgcat ctactttgac      900

cgggacctgc acacaaacag cccaaggcac agcaagggct cctacaatga cttcagcttc      960

gtgacgcaca ccaatagaga gggcgtcccc atgcgtaagg gcgagcacct gggcgagttc     1020

aacctgggct ccaccatcgt gctcatcttc gaggccccca aggacttcaa tttccagctg     1080

aaaacaggac agaaaatccg ctttggggaa gccctgggct cgctctag                  1128


<210>  441
<211>  813
<212>  DNA
<213>  Homo sapiens;

<400>  441
atggtgctgc tcaaggagta tcgagtaatc ctgcctgtgt ctgtagatga gtatcaagtg       60

gggcagctgt attctgtggc tgaggccagt aaaaatgaaa cgggtggtgg cgaaggcgtg      120

gaggtcctgg tgaatgagcc ctacgagaag gacggtgaga aaggccagta cacacacaag      180

atctaccacc tgcagagcaa agtacccacg tttgttcgaa tgctggcccc agagggagcc      240

ctgaatatac acgagaaagc ctggaatgct tacccctact gcagaaccgt tattacaaat      300

gagtacatga aagaagactt tctgattaaa attgaaacct ggcacaaacc agatcttggc      360

acgcaggaga atgtgcataa gctggagcct gaggcgtgga aacacgtgga agccgtatat      420

atagacattg cagatcgaag ccaagtgctc agcaaggatt acaaggcaga ggaagaccca      480

gcaaaattta aatctatcaa aacaggccga ggacccttgg gccccaattg gaagcaagag      540

cttgtaaacc agaaggactg cccatatatg tgtgcataca aactggtgac cgtcaagttc      600

aagtggtggg gcctgcagaa caaagtggag aacttcatcc ataagcaaga gaggcgtctg      660

tttacaaact tccacaggca gctgttctgt tggctcgata agtgggttga cctgaccatg      720

gacgacattc gaaggatgga agaagagacg aagagacagc tggatgaaat gagacaaaag      780

gacccagtga aaggaatgac agcagatgac taa                                   813


<210>  442
<211>  1230
<212>  DNA
<213>  Homo sapiens;

<400>  442
atgatgaaga agaacaattc cgccaagcgg ggacctcagg atggaaacca gcagcctgca       60

ccgcccgaga aggtcggctg ggtccggaaa ttctgcggga aagggatttt cagggagatt      120

tggaaaaacc gctatgtggt gctgaaaggg gaccagctct acatctctga gaaggaggta      180

aaagatgaga aaaatattca agaggtattt gacctgagtg actatgagaa gtgtgaagag      240

ctccggaagt ccaagagcag gagcaagaaa aatcatagca agtttactct tgcccactcc      300

aaacagcccg gtaacacggc acccaacctg atcttcctgg cagtgagtcc agaagagaag      360

gaatcgtgga tcaatgccct caactctgcc atcacccgag ccaagaaccg tatcttggat      420

gaggtcaccg ttgaggagga cagctatctt gcccatccca ctcgagacag ggcaaaaatc      480

cagcactccc gccgcccccc aacaagggga cacctaatgg ctgtggcttc cacctctacc      540

tcggatggga tgctgacctt ggacttgatc caagaggaag acccttcccc tgaggaacca      600

acctcttgtg ctgagagctt tcgggttgac ctggacaagt ctgtggccca gctggcaggg      660

agccggcgga gagcggactc agaccgcatc cagccctccg cagaccgggc aagcagtctc      720

tcccgacctt gggaaaaaac agacaaaggg gccacctaca ccccccaggc acccaagaag      780

ttgacgccca cagagaaagg ccgctgcgcc tccctggagg agatcctatc tcagcgggat      840

gctgcctctg cccgcaccct ccagctgcgg gctgaggaac ccccaacccc tgccctcccc      900

aacccggggc agctgtcccg gatccaggac ctggtagcaa ggaaactgga ggagactcag      960

gagcttctgg cagaggttca gggactggga gatgggaagc gaaaggccaa ggacccccct     1020

cggtctccgc cggattctga gtcagagcag ctgctgctgg agacggaacg gctgctggga     1080

gaggcatcat cgaattggag ccaggcaaag agggtgctgc aggaggtcag ggagctgaga     1140

gacctgtaca gacagatgga cctgcagacc ccggactccc acctcagaca gaccaccccg     1200

cacagtcagt accggaagag cctgatgtga                                      1230


<210>  443
<211>  1473
<212>  DNA
<213>  Homo sapiens;

<400>  443
atggaggagg agggtgtgaa ggaagccggt gagaagcctc ggggagcaca gatggtggac       60

aaggctggct ggatcaagaa gagcagtggg ggcctcctgg gtttctggaa agaccgatat      120

ctgctcctct gccaggccca gctgctggtc tatgagaatg aggatgatca gaagtgtgtg      180

gagactgtgg agctgggcag ctatgagaag tgccaggacc ttcgtgccct cctcaagcga      240

aaacaccgct ttatcctgct gcgatcccca gggaacaagg tcagcgacat caaattccag      300

gcacccaccg gggaggagaa ggaatcctgg atcaaagccc tcaatgaagg gattaaccga      360

ggcaaaaaca aggctttcga tgaggtaaag gtggacaaga gctgcgccct ggagcatgtg      420

acacgggacc gggtgcgagg gggccagcga cgccggccac caacgagagt ccacctgaag      480

gaggtggcca gtgcagcttc tgacggtctt ctgcgcctgg atcttgatgt tccggacagt      540

gggccaccag tgtttgcccc cagcaatcat gtcagtgaag cccaacctcg ggagacaccc      600

cggcccctca tgcctcctac caagcctttc ctagcacctg agaccaccag ccctggtgac      660

agggtggaga cccctgtggg ggagagagcc ccaacccctg tctcagcaag ctctgaggtc      720

tcccctgaga gccaagagga ctcagagacc ccagcagagg aggacagtgg ctctgagcag      780

cctcccaaca gcgtcctgcc tgacaaactg aaggtgagct gggagaaccc cagcccccag      840

gaggcccctg ctgcagagag tgcagaaccg tcccaggcac cctgttctga gacttctgag      900

gctgccccca gggagggtgg gaagccccct acacccccac ccaagatctt atcagagaaa      960

ctgaaagcct ccatgggtga gatgcaggct tctgggccac ctgctccagg cacagtgcag     1020

gtctcagtga atggcatgga tgacagtcct gagcctgcca agccctctca ggctgagggc     1080

accccaggaa ctcctccaaa ggatgcaaca acatccacag cactgccccc ctgggacctg     1140

ccacctcagt tccatccccg ctgctcctcc cttggggact tgcttgggga aggcccgcgg     1200

catcccttgc agcccaggga acggctatat cgggcccagc tggaggtgaa ggtggcctcg     1260

gaacagacgg agaaactgtt gaacaaggtg ctgggcagtg agccggcccc tgttagtgcc     1320

gaaacattgc tcagccaggc tgtggagcag ctgaggcagg ccacccaggt cctgcaggaa     1380

atgagagatt tgggagagct gagccaggaa gcacctgggc taagggagaa gcggaaggag     1440

ctggtgaccc tctacaggag aagtgcaccc tag                                  1473


<210>  444
<211>  4707
<212>  DNA
<213>  Homo sapiens;

<400>  444
atggaggtct cccggaggaa ggcgccgccg cgccccccgc gccccgcagc gccactgccc       60

ctgctcgcct atctgctggc actggcggct cccggccggg gcgcggacga gcccgtgtgg      120

cggtcggagc aagccatcgg agccatcgcg gcgagccagg aggacggcgt gtttgtggcg      180

agcggcagct gcctggacca gctggactac agcctggagc acagcctctc gcgcctgtac      240

cgggaccaag cgggcaactg cacagagccg gtctcgctgg cgccccccgc gcggccccgg      300

cccgggagca gcttcagcaa gctgctgctg ccctaccgcg agggggcggc cggcctcggg      360

gggctgctgc tcaccggctg gaccttcgac cggggcgcct gcgaggtgcg gcccctgggc      420

aacctgagcc gcaactccct gcgcaacggc accgaggtgg tgtcgtgcca cccgcagggc      480

tcgacggccg gcgtggtgta ccgcgcgggc cggaacaacc gctggtacct ggcggtggcc      540

gccacctacg tgctgcctga gccggagacg gcgagccgct gcaaccccgc ggcatccgac      600

cacgacacgg ccatcgcgct caaggacacg gaggggcgca gcctggccac gcaggagctg      660

gggcgcctca agctgtgcga gggcgcgggc agcctgcact tcgtggacgc ctttctctgg      720

aacggcagca tctacttccc ctactacccc tacaactaca cgagcggcgc tgccaccggc      780

tggcccagca tggcgcgcat cgcgcagagc accgaggtgc tgttccaggg ccaggcatcc      840

ctcgactgcg gccacggcca ccccgacggc cgccgcctgc tcctctcctc cagcctagtg      900

gaggccctgg acgtctgggc gggagtgttc agcgcggccg ctggagaggg ccaggagcgg      960

cgctccccca ccaccacggc gctctgcctc ttcagaatga gtgagatcca ggcgcgcgcc     1020

aagagggtca gctgggactt caagacggcc gagagccact gcaaagaagg ggatcaacct     1080

gaaagagtcc aaccaatcgc atcatctacc ttgatccatt ccgacctgac atccgtttat     1140

ggcaccgtgg taatgaacag gactgtttta ttcttgggga ctggagatgg ccagttactt     1200

aaggttattc ttggtgagaa tttgacttca aattgtccag aggttatcta tgaaattaaa     1260

gaagagacac ctgttttcta caaactcgtt cctgatcctg tgaagaatat ctacatttat     1320

ctaacagctg ggaaagaggt gaggagaatt cgtgttgcaa actgcaataa acataaatcc     1380

tgttcggagt gtttaacagc cacagaccct cactgcggtt ggtgccattc gctacaaagg     1440

tgcacttttc aaggagattg tgtacattca gagaacttag aaaactggct ggatatttcg     1500

tctggagcaa aaaagtgccc taaaattcag ataattcgaa gcagtaaaga aaagactaca     1560

gtgactatgg tgggaagctt ctctccaaga cactcaaagt gcatggtgaa gaatgtggac     1620

tctagcaggg agctctgcca gaataaaagt cagcccaacc ggacctgcac ctgtagcatc     1680

ccaaccagag caacctacaa agatgtttca gttgtcaacg tgatgttctc cttcggttct     1740

tggaatttat cagacagatt caactttacc aactgctcat cattaaaaga atgcccagca     1800

tgcgtagaaa ctggctgcgc gtggtgtaaa agtgcaagaa ggtgtatcca ccccttcaca     1860

gcttgcgacc cttctgatta tgagagaaac caggaacagt gtccagtggc tgtcgagaag     1920

acatcaggag gaggaagacc caaggagaac aaggggaaca gaaccaacca ggctttacag     1980

gtcttctaca ttaagtccat tgagccacag aaagtatcga cattagggaa aagcaacgtg     2040

atagtaacgg gagcaaactt tacccgggca tcgaacatca caatgatcct gaaaggaacc     2100

agtacctgtg ataaggatgt gatacaggtt agccatgtgc taaatgacac ccacatgaaa     2160

ttctctcttc catcaagccg gaaagaaatg aaggatgtgt gtatccagtt tgatggtggg     2220

aactgctctt ctgtgggatc cttatcctac attgctctgc cacattgttc ccttatattt     2280

cctgctacca cctggatcag tggtggtcaa aatataacca tgatgggcag aaattttgat     2340

gtaattgaca acttaatcat ttcacatgaa ttaaaaggaa acataaatgt ctctgaatat     2400

tgtgtggcga cttactgcgg gtttttagcc cccagtttaa agagttcaaa agtgcgcacg     2460

aatgtcactg tgaagctgag agtacaagac acctacttgg attgtggaac cctgcagtat     2520

cgggaggacc ccagattcac ggggtatcgg gtggaatccg aggtggacac agaactggaa     2580

gtgaaaattc aaaaagaaaa tgacaacttc aacatttcca aaaaagacat tgaaattact     2640

ctcttccatg gggaaaatgg gcaattaaat tgcagttttg aaaatattac tagaaatcaa     2700

gatcttacca ccatcctttg caaaattaaa ggcatcaaga ctgcaagcac cattgccaac     2760

tcttctaaga aagttcgggt caagctggga aacctggagc tctacgtcga gcaggagtca     2820

gttccttcca catggtattt tctgattgtg ctccctgtct tgctagtgat tgtcattttt     2880

gcggccgtgg gggtgaccag gcacaaatcg aaggagctga gtcgcaaaca gagtcaacaa     2940

ctagaattgc tggaaagcga gctccggaaa gagatacgtg acggctttgc tgagctgcag     3000

atggataaat tggatgtggt tgatagtttt ggaactgttc ccttccttga ctacaaacat     3060

tttgctctga gaactttctt ccctgagtca ggtggcttca cccacatctt cactgaagat     3120

atgcataaca gagacgccaa cgacaagaat gaaagtctca cagctttgga tgccctaatc     3180

tgtaataaaa gctttcttgt tactgtcatc cacacccttg aaaagcagaa gaacttttct     3240

gtgaaggaca ggtgtctgtt tgcctccttc ctaaccattg cactgcaaac caagctggtc     3300

tacctgacca gcatcctaga ggtgctgacc agggacttga tggaacagtg tagtaacatg     3360

cagccgaaac tcatgctgag acgcacggag tccgtcgtcg aaaaactcct cacaaactgg     3420

atgtccgtct gcctttctgg atttctccgg gagactgtcg gagagccctt ctatttgctg     3480

gtgacgactc tgaaccagaa aattaacaag ggtcccgtgg atgtaatcac ttgcaaagcc     3540

ctgtacacac ttaatgaaga ctggctgttg tggcaggttc cggaattcag tactgtggca     3600

ttaaacgtcg tctttgaaaa aatcccggaa aacgagagtg cagatgtctg tcggaatatt     3660

tcagtcaatg ttctcgactg tgacaccatt ggccaagcca aagaaaagat tttccaagca     3720

ttcttaagca aaaatggctc tccttatgga cttcagctta atgaaattgg tcttgagctt     3780

caaatgggca cacgacagaa agaacttctg gacatcgaca gttcctccgt gattcttgaa     3840

gatggaatca ccaagctaaa caccattggc cactatgaga tatcaaatgg atccactata     3900

aaagtcttta agaagatagc aaattttact tcagatgtgg agtactcgga tgaccactgc     3960

catttgattt taccagattc ggaagcattc caagatgtgc aaggaaagag acatcgaggg     4020

aagcacaagt tcaaagtaaa agaaatgtat ctgacaaagc tgctgtcgac caaggtggca     4080

attcattctg tgcttgaaaa actttttaga agcatttgga gtttacccaa cagcagagct     4140

ccatttgcta taaaatactt ttttgacttt ttggacgccc aggctgaaaa caaaaaaatc     4200

acagatcctg acgtcgtaca tatttggaaa acaaacagcc ttcctcttcg cttctgggta     4260

aacatcctga agaaccctca gtttgtcttt gacattaaga agacaccaca tatagacggc     4320

tgtttgtcag tgattgccca ggcattcatg gatgcatttt ctctcacaga gcagcaacta     4380

gggaaggaag caccaactaa taagcttctc tatgccaagg atatcccaac ctacaaagaa     4440

gaagtaaaat cttattacaa agcaatcagg gatttgcctc cattgtcatc ctcagaaatg     4500

gaagaatttt taactcagga atctaagaaa catgaaaatg aatttaatga agaagtggcc     4560

ttgacagaaa tttacaaata catcgtaaaa tattttgatg agattctaaa taaactagaa     4620

agagaacgag ggctggaaga agctcagaaa caactcttgc atgtaaaagt cttatttgat     4680

gaaaagaaga aatgcaagtg gatgtaa                                         4707


<210>  445
<211>  1008
<212>  DNA
<213>  Homo sapiens;

<400>  445
atgagcaaac ggaaggcgcc gcaggagact ctcaacgggg gaatcaccga catgctcaca       60

gaactcgcaa actttgagaa gaacgtgagc caagctatcc acaagtacaa tgcttacaga      120

aaagcagcat ctgttatagc aaaataccca cacaaaataa agagtggagc tgaagctaag      180

aaattgcctg gagtaggaac aaaaattgct gaaaagattg atgagttttt agcaactgga      240

aaattacgta aactggaaaa gattcggcag gatgatacga gttcatccat caatttcctg      300

actcgagtta gtggcattgg tccatctgct gcaaggaagt ttgtagatga aggaattaaa      360

acactagaag atctcagaaa aaatgaagat aaattgaacc atcatcagcg aattgggctg      420

aaatattttg gggactttga aaaaagaatt cctcgtgaag agatgttaca aatgcaagat      480

attgtactaa atgaagttaa aaaagtggat tctgaataca ttgctacagt ctgtggcagt      540

ttcagaagag gtgcagagtc cagtggtgac atggatgttc tcctgaccca tcccagcttc      600

acttcagaat caaccaaaca gccaaaactg ttacatcagg ttgtggagca gttacaaaag      660

gttcatttta tcacagatac cctgtcaaag ggtgagacaa agttcatggg tgtttgccag      720

cttcccagta aaaatgatga aaaagaatat ccacacagaa gaattgatat caggttgata      780

cccaaagatc agtattactg tggtgttctc tatttcactg ggagtgatat tttcaataag      840

aatatgaggg ctcatgccct agaaaagggt ttcacaatca atgagtacac catccgtccc      900

ttgggagtca ctggagttgc aggagaaccc ctgccagtgg atagtgaaaa agacatcttt      960

gattacatcc agtggaaata ccgggaaccc aaggaccgga gcgaatga                  1008


<210>  446
<211>  324
<212>  DNA
<213>  Homo sapiens;

<400>  446
atgggccgga agcggctcat cactgattcc tacccggttg tgaagaggag ggaggggccc       60

gctgggcaca gcaaggggga gctggcaccc gagctagggg aggagcccca gccccgcgac      120

gaggaggaag cggagctgga gctgctgagg cagtttgacc tggcctggca gtacgggccc      180

tgcaccggga tcacacggct gcagcgctgg tgtcgggcca agcagatggg cttggagcct      240

cccccagagg tgtggcaggt gctgaagacc caccccggag acccccgctt ccagtgcagt      300

ctctggcatc tctatcccct atga                                             324


<210>  447
<211>  402
<212>  DNA
<213>  Homo sapiens;

<400>  447
atggaagagg atcaggagct ggagagaaaa atatctggat tgaagacctc aatggctgaa       60

ggcgagagga agacagccct ggaaatggtc caggcagctg gaacagatag acactgtgtg      120

acatttgtat tgcacgagga agaccatacc ctaggaaatt ctctacgtta catgatcatg      180

aagaacccgg aagtggaatt ttgtggttac actacgaccc atccttcaga gagcaaaatt      240

aatttacgca ttcagactcg aggtaccctt ccagctgttg agccatttca gagaggcctg      300

aatgagctca tgaatgtctg ccaacatgtg cttgacaagt ttgaggccag cataaaggac      360

tataaggatc aaaaagcaag cagaaatgaa tccacattct ag                         402


<210>  448
<211>  1326
<212>  DNA
<213>  Homo sapiens;

<400>  448
atggagcagc cacaggagga agcccctgag gtccgggaag aggaggagaa agaggaagtg       60

gcagaggcag aaggagcccc agagctcaat gggggaccac agcatgcact tccttccagc      120

agctacacag acctctcccg gagctcctcg ccaccctcac tgctggacca actgcagatg      180

ggctgtgacg gggcctcatg cggcagcctc aacatggagt gccgggtgtg cggggacaag      240

gcatcgggct tccactacgg tgttcatgca tgtgaggggt gcaagggctt cttccgtcgt      300

acgatccgca tgaagctgga gtacgagaag tgtgagcgca gctgcaagat tcagaagaag      360

aaccgcaaca agtgccagta ctgccgcttc cagaagtgcc tggcactggg catgtcacac      420

aacgctatcc gttttggtcg gatgccggag gctgagaaga ggaagctggt ggcagggctg      480

actgcaaacg aggggagcca gtacaaccca caggtggccg acctgaaggc cttctccaag      540

cacatctaca atgcctacct gaaaaacttc aacatgacca aaaagaaggc ccgcagcatc      600

ctcaccggca aagccagcca cacggcgccc tttgtgatcc acgacatcga gacattgtgg      660

caggcagaga aggggctggt gtggaagcag ttggtgaatg gcctgcctcc ctacaaggag      720

atcagcgtgc acgtcttcta ccgctgccag tgcaccacag tggagaccgt gcgggagctc      780

actgagttcg ccaagagcat ccccagcttc agcagcctct tcctcaacga ccaggttacc      840

cttctcaagt atggcgtgca cgaggccatc ttcgccatgc tggcctctat cgtcaacaag      900

gacgggctgc tggtagccaa cggcagtggc tttgtcaccc gtgagttcct gcgcagcctc      960

cgcaaaccct tcagtgatat cattgagcct aagtttgaat ttgctgtcaa gttcaacgcc     1020

ctggaacttg atgacagtga cctggcccta ttcattgcgg ccatcattct gtgtggagac     1080

cggccaggcc tcatgaacgt tccacgggtg gaggctatcc aggacaccat cctgcgtgcc     1140

ctcgaattcc acctgcaggc caaccaccct gatgcccagt acctcttccc caagctgctg     1200

cagaagatgg ctgacctgcg gcaactggtc accgagcacg cccagatgat gcagcggatc     1260

aagaagaccg aaaccgagac ctcgctgcac cctctgctcc aggagatcta caaggacatg     1320

tactaa                                                                1326


<210>  449
<211>  1365
<212>  DNA
<213>  Homo sapiens;

<400>  449
atgtcctctg gagccccaca gaagagcagc ccaatggcca gtggagctga ggagacccca       60

ggcttcctgg acacgctcct gcaagacttc ccagccctgc tgaacccaga ggaccctctg      120

ccatggaagg ccccagggac ggtgctcagc caggaggagg tggagggcga gctggctgag      180

ctggccatgg gctttctggg cagcaggaag gccccgccac cacttgctgc tgctctggcc      240

cacgaagcag tttcacagct gctacagaca gacctttccg aattcaggaa gttgcccagg      300

gaggaagaag aagaggagga ggacgatgac gaggaggaaa aggcccctgt gaccttgctg      360

gatgcccaaa gcctggcaca gagtttcttt aaccgccttt gggaagtcgc cggccagtgg      420

cagaagcagg tgccattggc tgcccgggcc tcacagcggc agtggctggt ctccatccac      480

gccatccgga acactcgccg caagatggag gaccggcacg tgtccctccc ttccttcaac      540

cagctcttcg gcttgtctga ccctgtgaac cgcgcctact ttgctgtgtt tgatggtcac      600

ggaggcgtgg atgctgcgag gtacgccgct gtccacgtgc acaccaacgc tgcccgccag      660

ccagagctgc ccacagaccc tgagggagcc ctcagagaag ccttccggcg caccgaccag      720

atgtttctca ggaaagccaa gcgagagcgg ctgcagagcg gcaccacagg tgtgtgtgcg      780

ctcattgcag gagcgaccct gcacgtcgcc tggctcgggg attcccaggt cattttggta      840

cagcagggac aggtggtgaa gctgatggag ccacacagac cagaacggca ggatgagaag      900

gcgcgcattg aagcattggg tggctttgtg tctcacatgg actgctggag agtcaacggg      960

accctggccg tctccagagc catcggggat gtcttccaga agccctacgt gtctggggag     1020

gccgatgcag cttcccgggc gctgacgggc tccgaggact acctgctgct tgcctgtgat     1080

ggcttctttg acgtcgtacc ccaccaggaa gttgttggcc tggtccagag ccacctgacc     1140

aggcagcagg gcagcgggct ccgtgtcgcc gaggagctgg tggctgcggc ccgggagcgg     1200

ggctcccacg acaacatcac ggtcatggtg gtcttcctca gggaccccca agagctgctg     1260

gagggcggga accagggaga aggggacccc caggcagaag ggaggaggca ggacttgccc     1320

tccagccttc cagaacctga gacccaggct ccaccaagaa gctag                     1365


<210>  450
<211>  381
<212>  DNA
<213>  Homo sapiens;

<400>  450
atggccgagg caggggctgg gctgagcgag accgtcactg agacaacggt taccgtgaca       60

accgagcccg agaaccggag ccttaccatc aaacttcgga aacggaagcc agagaaaaag      120

gtagaatgga caagtgacac tgtggacaat gaacacatgg gccgccgctc atccaaatgc      180

tgctgtattt atgagaaacc tcgggccttt ggcgagagct ccacggaaag tgatgaggag      240

gaagaagagg gctgtggtca tacacactgt gtacgtggcc accgcaaagg acggcgtcgt      300

gcaaccctag gaccgacccc caccacccct ccccagcctc ctgacccttc ccagccccct      360

ccagggccaa tgcagcacta a                                                381


<210>  451
<211>  618
<212>  DNA
<213>  Homo sapiens;

<400>  451
atggcggcct cgacggcctc gcaccggccc atcaagggga tcttgaagaa caagacctct       60

acgacttcct ctatggtggc gtcggccgaa cagccccgcg ggaatgtcga cgaggagctg      120

agcaaaaaat cccagaagtg ggatgaaatg aacatcttgg cgacgtatca tccagcagac      180

aaagactatg gtttaatgaa aatagatgaa ccaagcactc cttaccatag tatgatgggg      240

gatgatgaag atgcctgtag tgacaccgag gccactgaag ccatggcgcc agacatctta      300

gccaggaaat tagctgcagc tgaaggcttg gagccaaagt atcggattca ggaacaagaa      360

agcagtggag aggaggatag tgacctctca cctgaagaac gagaaaaaaa gcgacaattt      420

gaaatgaaaa ggaagcttca ctacaatgaa ggactcaata tcaaactagc cagacaatta      480

atttcaaaag acctacatga tgatgatgaa gatgaagaaa tgttagagac tgcagatgga      540

gaaagcatga atacggaaga atcaaatcaa ggatctactc caagtgacca acagcaaaac      600

aaattacgaa gttcatag                                                    618


<210>  452
<211>  1461
<212>  DNA
<213>  Homo sapiens;

<400>  452
atgtcgtcgt cgtcgccgcc ggcgggggct gccagcgccg ccatctcggc ctcggagaaa       60

gtggacggct tcacccggaa atcggtccgc aaggcgcaga ggcagaagcg ctcccagggc      120

tcgtcgcagt ttcgcagcca gggcagccag gcagagctgc acccgctgcc ccagctcaaa      180

gatgccactt caaatgaaca acaagagctt ttctgtcaga agttgcagca gtgttgtata      240

ctgtttgatt tcatggactc tgtttcagac ttgaagagca aagaaattaa aagagcaaca      300

ctgaatgaac tggttgagta tgtttcaact aatcgtggtg taattgttga atcagcgtat      360

tctgatatag taaaaatgat cagtgctaac atcttccgta cacttcctcc aagtgataat      420

ccagattttg atccagaaga ggatgaaccc acgcttgagg cctcttggcc tcacatacag      480

ttggtatatg aattcttctt gagatttttg gagagccctg atttccagcc tagcattgca      540

aaacgataca ttgatcagaa attcgtacaa cagctcctgg agctttttga tagtgaagat      600

cccagagaac gtgacttcct gaagactgtt ctgcaccgaa tttatgggaa atttcttgga      660

ttaagagcat tcatcagaaa acaaattaac aacattttcc tcaggtttat atatgaaaca      720

gaacatttca atggtgttgc tgaacttctt gaaatattag gaagtattat caatggcttt      780

gcattgccac tgaaagcaga acataaacaa tttctaatga aggttcttat tcctatgcat      840

actgcaaaag gattagcttt gtttcatgct cagctagcat attgtgttgt acagttcctg      900

gagaaagata caacactaac agagccagtg atcagaggac tgctgaaatt ttggccaaaa      960

acctgcagtc agaaagaggt gatgttttta ggagaaattg aagaaatctt agatgtcatt     1020

gaaccaacac agttcaaaaa aattgaagag ccacttttca agcagatatc caagtgtgta     1080

tccagttctc attttcaggt tgcagaaagg gcattgtact tctggaataa cgaatatatt     1140

cttagtttga ttgaggagaa cattgataaa attctgccaa ttatgtttgc cagtttgtac     1200

aaaatttcca aagaacactg gaatccgacc attgtagcac tggtatacaa tgtgctgaaa     1260

accctaatgg aaatgaatgg caagcttttc gatgacctta ctagctcata caaagctgaa     1320

agacagagag agaaaaagaa ggaattggaa cgtgaagaat tatggaaaaa attagaggag     1380

ctaaagctaa agaaagctct agaaaaacag aatagtgctt acaacatgca cagtattctc     1440

agcaatacaa gtgccgaata a                                               1461


<210>  453
<211>  513
<212>  DNA
<213>  Homo sapiens;

<400>  453
atgggaaatg aggcaagtta tcctttggaa atgtgctcac actttgatgc ggatgaaatt       60

aaaaggctag gaaagagatt taagaagctt gatttggaca attctggttc tttgagtgtg      120

gaagagttca tgtctctgcc tgagttacaa cagaatcctt tagtacagcg agtaatagat      180

atattcgaca cagatgggaa tggagaagta gactttaaag aattcattga gggcgtctct      240

cagttcagtg tcaaaggaga taaggagcag aaattgaggt ttgctttccg tatctatgac      300

atggataaag atggctatat ttccaatggg gaactcttcc aggtattgaa gatgatggtg      360

gggaacaatc tgaaagatac acagttacag caaattgtag acaaaaccat aataaatgca      420

gataaggatg gagatggaag aatatccttt gaagaattct gtgctgttgt aggtggccta      480

gatatccaca aaaagatggt ggtagatgtg tga                                   513


<210>  454
<211>  2802
<212>  DNA
<213>  Homo sapiens;

<400>  454
atggcggacc tctcgctgct tcaggaggac ctgcaggagg acgcagacgg atccctggac       60

tttgtctcac aagatgaaat gttgacgccc ctggggagat tggacaagta tgctgcaagt      120

gagaacatat ttaacagaca aatggtggcc cggagtttgc tcgatacctt gagggaagtc      180

tgcgatgatg aaagagattg tattgctgtt ttggaaagaa ttagcagatt ggccgatgat      240

tcagaaccaa ctgtgagagc ggagctgatg gaacaggtgc ctcacatcgc actgttttgt      300

caagaaaacc ggccttcaat accatatgct ttttcaaaat tcttactacc tattgtggtt      360

agataccttg cagatcagaa taatcaggtg aggaaaacaa gtcaggcagc tttgctggct      420

ctgttggagc aggagctcat tgaacgattt gatgtggaga ccaaagtgtg ccctgtcctc      480

atagagctga cagccccaga tagcaatgat gatgtgaaaa cagaagctgt ggctataatg      540

tgcaaaatgg ctcccatggt tgggaaggat attacagagc gtcttatcct ccctaggttt      600

tgtgagatgt gctgcgattg cagaatgttt cacgttcgaa aggtctgtgc tgccaatttt      660

ggagatattt gcagtgtagt tggccagcaa gctactgaag aaatgttgct gcccagattt      720

ttccagcttt gttctgataa tgtatgggga gtccgaaagg cttgtgctga atgcttcatg      780

gcggtttcat gtgcaacatg tcaagaaatc cgacggacca aattatcagc actttttatt      840

aatttgatca gtgatccttc acgttgggtt cgccaagcag cttttcagtc tctgggacct      900

ttcatatcta cttttgctaa tccatctagc tcaggccagt attttaaaga agaaagcaaa      960

agttcagaag agatgtcagt agaaaacaaa aataggacca gagatcaaga agccccagag     1020

gatgtacaag tcaggccaga ggatactcct tcagatctca gtgttagtaa ttccagtgtc     1080

atactggaaa acacgatgga agaccatgct gctgaggcat ccgggaagcc tctaggtgaa     1140

attagtgttc cactggacag ctctttactt tgtactttgt cctcagaatc tcaccaggaa     1200

gcagctagta atgagaatga taaaaaacct ggtaactaca aatctatgtt acgaccagag     1260

gttggcacca cttcacaaga ttcagctctc ttagatcagg aattgtataa ctccttccat     1320

ttctggagga ctcctcttcc tgaaatagat ctagacatag agcttgaaca gaactctggg     1380

ggaaaaccca gcccagaggg accagaggaa gaatctgagg gccctgtgcc cagttctcca     1440

aacatcacca tggccaccag aaaggaactg gaagaaatga tagaaaatct agagccccac     1500

attgatgatc cagatgttaa agcacaagtg gaagtgctgt ccgctgcact acgtgcttcc     1560

agcctggatg cacatgaaga gaccatcagt atagaaaaga gaagtgattt gcaagatgaa     1620

ctggatataa atgagctacc aaattgtaaa ataaatcaag aagattctgt gcctttaatc     1680

agcgatgctg ttgagaatat ggactccact cttcactata ttcacagcga ttcagacttg     1740

agcaacaata gcagttttag ccctgatgag gaaaggagaa ctaaagtaca agatgttgta     1800

cctcaggcgt tgttagatca gtatttatct atgactgacc cttctcgtgc acagacggtt     1860

gacactgaaa ttgctaagca ctgtgcatat agcctccctg gtgtggcctt gacactcgga     1920

agacagaatt ggcactgcct gagagagacg tatgagactc tggcctcaga catgcagtgg     1980

aaagttcgac gaactctagc attctccatc cacgagcttg cagttattct tggagatcaa     2040

ttgacagctg cagatctggt tccaattttt aatggatttt taaaagacct cgatgaagtc     2100

aggataggtg ttcttaaaca cttgcatgat tttctgaagc ttcttcatat tgacaaaaga     2160

agagaatatc tttatcaact tcaggagttt ttggtgacag ataatagtag aaattggcgg     2220

tttcgagctg aactggctga acagctgatt ttacttctag agttatatag tcccagagat     2280

gtttatgact atttacgtcc cattgctctg aatctgtgtg cagacaaagt ttcttctgtt     2340

cgttggattt cctacaagtt ggtcagcgag atggtgaaga agctgcacgc ggcaacacca     2400

ccaacgttcg gagtggacct catcaatgag cttgtggaga actttggcag atgtcccaag     2460

tggtctggtc ggcaagcctt tgtctttgtc tgccagactg tcattgagga tgactgcctt     2520

cccatggacc agtttgctgt gcatctcatg ccgcatctgc taaccttagc aaatgacagg     2580

gttcctaacg tgcgagtgct gcttgcaaag acattaagac aaactctact agaaaaagac     2640

tatttcttgg cctctgccag ctgccaccag gaggctgtgg agcagaccat catggctctt     2700

cagatggacc gtgacagcga tgtcaagtat tttgcaagca tccaccctgc cagtaccaaa     2760

atctccgaag atgccatgag cacagcgtcc tcaacctact ag                        2802


<210>  455
<211>  1680
<212>  DNA
<213>  Homo sapiens;

<400>  455
atgcgcagac tcagttcctg gagaaagatg gcgacagccg agaagcagaa acacgacggg       60

cgggtgaaga tcggccacta cattctgggt gacacgctgg gggtcggcac cttcggcaaa      120

gtgaaggttg gcaaacatga attgactggg cataaagtag ctgtgaagat actcaatcga      180

cagaagattc ggagccttga tgtggtagga aaaatccgca gagaaattca gaacctcaag      240

cttttcaggc atcctcatat aattaaactg taccaggtca tcagtacacc atctgatatt      300

ttcatggtga tggaatatgt ctcaggagga gagctatttg attatatctg taagaatgga      360

aggctggatg aaaaagaaag tcggcgtctg ttccaacaga tcctttctgg tgtggattat      420

tgtcacaggc atatggtggt ccatagagat ttgaaacctg aaaatgtcct gcttgatgca      480

cacatgaatg caaagatagc tgattttggt ctttcaaaca tgatgtcaga tggtgaattt      540

ttaagaacaa gttgtggctc acccaactat gctgcaccag aagtaatttc aggaagattg      600

tatgcaggcc cagaggtaga tatatggagc agtggggtta ttctctatgc tttattatgt      660

ggaacccttc catttgatga tgaccatgtg ccaactcttt ttaagaagat atgtgatggg      720

atcttctata cccctcaata tttaaatcct tctgtgatta gccttttgaa acatatgctg      780

caggtggatc ccatgaagag ggccacaatc aaagatatca gggaacatga atggtttaaa      840

caggaccttc caaaatatct ctttcctgag gatccatcat atagttcaac catgattgat      900

gatgaagcct taaaagaagt atgtgaaaag tttgagtgct cagaagagga agttctcagc      960

tgtctttaca acagaaatca ccaggatcct ttggcagttg cctaccatct cataatagat     1020

aacaggagaa taatgaatga agccaaagat ttctatttgg cgacaagccc acctgattct     1080

tttcttgatg atcatcacct gactcggccc catcctgaaa gagtaccatt cttggttgct     1140

gaaacaccaa gggcacgcca tacccttgat gaattaaatc cacagaaatc caaacaccaa     1200

ggtgtaagga aagcaaaatg gcatttagga attagaagtc aaagtcgacc aaatgatatt     1260

atggcagaag tatgtagagc aatcaaacaa ttggattatg aatggaaggt tgtaaaccca     1320

tattatttgc gtgtacgaag gaagaatcct gtgacaagca cttactccaa aatgagtcta     1380

cagttatacc aagtggatag tagaacttat ctactggatt tccgtagtat tgatgatgaa     1440

attacagaag ccaaatcagg gactgctact ccacagagat cgggatcagt tagcaactat     1500

cgatcttgcc aaaggagtga ttcagatgct gaggctcaag gaaaatcctc agaagtttct     1560

cttacctcat ctgtgacctc acttgactct tctcctgttg acctaactcc aagacctgga     1620

agtcacacaa tagaattttt tgagatgtgt gcaaatctaa ttaaaattct tgcacaataa     1680


<210>  456
<211>  1710
<212>  DNA
<213>  Homo sapiens;

<400>  456
atgggaagcg cggttatgga caccaagaag aaaaaagatg tttccagccc cggcgggagc       60

ggcggcaaga aaaatgccag ccagaagagg cgttcgctgc gcgtgcacat tccggacctg      120

agctccttcg ccatgccgct cctggacgga gacctggagg gttccggaaa gcattcctct      180

cgaaaggtgg acagcccctt cggcccgggc agcccctcca aagggttctt ctccagaggc      240

ccccagcccc ggccctccag ccccatgtct gcacctgtga ggcccaagac cagccccggc      300

tctcccaaaa ccgtgttccc gttctcctac caggagtccc cgccacgctc ccctcgacgc      360

atgagcttca gtgggatctt ccgctcctcc tccaaagagt cttcccccaa ctccaaccct      420

gctacctcgc ccgggggcat caggtttttc tcccgctcca gaaaaacctc cggcctctcc      480

tcctctccgt caacacccac ccaagtgacc aagcagcaca cgtttcccct ggaatcctat      540

aagcacgagc ctgaacggtt agagaatcgc atctatgcct cgtcttcccc cccggacaca      600

gggcagaggt tctgcccgtc ttccttccag agcccgacca ggcctccact ggcatcaccg      660

acacactatg ctccctccaa agccgcggcg ctggcggcgg ccctgggacc cgcggaagcc      720

ggcatgctgg agaagctgga gttcgaggac gaagcagtag aagactcaga aagtggtgtt      780

tacatgcgat tcatgaggtc acacaagtgt tatgacatcg ttccaaccag ttcaaagctt      840

gttgtctttg atactacatt acaagttaaa aaggccttct ttgctttggt agccaacggt      900

gtccgagcag cgccactgtg ggagagtaaa aaacaaagtt ttgtaggaat gctaacaatt      960

acagatttca taaatatact acatagatac tataaatcac ctatggtaca gatttatgaa     1020

ttagaggaac ataaaattga aacatggagg gagctttatt tacaagaaac atttaagcct     1080

ttagtgaata tatctccaga tgcaagcctc ttcgatgctg tatactcctt gatcaaaaat     1140

aaaatccaca gattgcccgt tattgaccct atcagtggga atgcacttta tatacttacc     1200

cacaaaagaa tcctcaagtt cctccagctt tttatgtctg atatgccaaa gcctgccttc     1260

atgaagcaga acctggatga gcttggaata ggaacgtacc acaacattgc cttcatacat     1320

ccagacactc ccatcatcaa agccttgaac atatttgtgg aaagacgaat atcagctctg     1380

cctgttgtgg atgagtcagg aaaagttgta gatatttatt ccaaatttga tgtaattaat     1440

cttgctgctg agaaaacata caataaccta gatatcacgg tgacccaggc ccttcagcac     1500

cgttcacagt attttgaagg tgttgtgaag tgcaataagc tggaaatact ggagaccatc     1560

gtggacagaa tagtaagagc tgaggtccat cggctggtgg tggtaaatga agcagatagt     1620

attgtgggta ttatttccct gtcggacatt ctgcaagccc tgatcctcac accagcaggt     1680

gccaaacaaa aggagacaga aacggagtga                                      1710


<210>  457
<211>  2031
<212>  DNA
<213>  Homo sapiens;

<400>  457
atggcgccgt tcctgcgcat cgccttcaac tcctatgagc tgggctccct gcaggccgag       60

gacgaggcga accagccctt ctgtgccgtg aagatgaagg aggcgctcag cacagagcgt      120

gggaaaacac tggtgcagaa gaagccgacc atgtatcctg agtggaagtc gacgttcgat      180

gcccacatct atgaggggcg cgtcatccag attgtgctaa tgcgggcagc agaggagcca      240

gtgtctgagg tgaccgtggg tgtgtcggtg ctggccgagc gctgcaagaa gaacaatggc      300

aaggctgagt tctggctgga cctgcagcct caggccaagg tgttgatgtc tgttcagtat      360

ttcctggagg acgtggattg caaacagtct atgcgcagtg aggacgaggc caagttccca      420

acgatgaacc gccgcggagc catcaaacag gccaaaatcc actacatcaa gaaccatgag      480

tttatcgcca ccttctttgg gcaacccacc ttctgttctg tgtgcaaaga ctttgtctgg      540

ggcctcaaca agcaaggcta caaatgcagg caatgtaacg ctgccatcca caagaaatgc      600

atcgacaaga tcatcggcag atgcactggc accgcggcca acagccggga cactatattc      660

cagaaagaac gcttcaacat cgacatgccg caccgcttca aggttcacaa ctacatgagc      720

cccaccttct gtgaccactg cggcagcctg ctctggggac tggtgaagca gggattaaag      780

tgtgaagact gcggcatgaa tgtgcaccat aaatgccggg agaaggtggc caacctctgc      840

ggcatcaacc agaagctttt ggctgaggcc ttgaaccaag tcacccagag agcctcccgg      900

agatcagact cagcctcctc agagcctgtt gggatatatc agggtttcga gaagaagacc      960

ggagttgctg gggaggacat gcaagacaac agtgggacct acggcaagat ctgggagggc     1020

agcagcaagt gcaacatcaa caacttcatc ttccacaagg tcctgggcaa aggcagcttc     1080

gggaaggtgc tgcttggaga gctgaagggc agaggagagt actttgccat caaggccctc     1140

aagaaggatg tggtcctgat cgacgacgac gtggagtgca ccatggttga gaagcgggtg     1200

ctgacacttg ccgcagagaa tccctttctc acccacctca tctgcacctt ccagaccaag     1260

gaccacctgt tctttgtgat ggagttcctc aacggggggg acctgatgta ccacatccag     1320

gacaaaggcc gctttgaact ctaccgtgcc acgttttatg ccgctgagat aatgtgtgga     1380

ctgcagtttc tacacagcaa gggcatcatt tacagggacc tcaaactgga caatgtgctg     1440

ctggaccggg atggccacat caagattgcc gactttggga tgtgcaaaga gaacatattc     1500

ggggagagcc gggccagcac cttctgcggc acccctgact atatcgcccc tgagatccta     1560

cagggcctga agtacacatt ctctgtggac tggtggtctt tcggggtcct tctgtacgag     1620

atgctcattg gccagtcccc cttccatggt gatgatgagg atgaactctt cgagtccatc     1680

cgtgtggaca cgccacatta tccccgctgg atcaccaagg agtccaagga catcctggag     1740

aagctctttg aaagggaacc aaccaagagg ctgggagtga ccggaaacat caaaatccac     1800

cccttcttca agaccataaa ctggactctg ctggaaaagc ggaggttgga gccacctttc     1860

aggcccaaag tgaagtcacc cagagactac agtaactttg accaggagtt cctgaacgag     1920

aaggcgcgcc tctcctacag cgacaagaac ctcatcgact ccatggacca gtctgcattc     1980

gctggcttct cctttgtgaa ccccaaattc gagcacctcc tggaagattg a              2031


<210>  458
<211>  1302
<212>  DNA
<213>  Homo sapiens;

<400>  458
atggcaacat caggtgactg tcccagaagt gaatcgcagg gagaagagcc tgctgagtgc       60

agtgaggccg gtctcctgca ggagggagta cagccagagg agtttgtggc catcgcggac      120

tacgctgcca ccgatgagac ccagctcagt tttttgagag gagaaaaaat tcttatcctg      180

agacaaacca ctgcagattg gtggtggggt gagcgtgcgg gctgctgtgg gtacattccg      240

gcaaaccatg tggggaagca cgtggatgag tacgaccccg aggacacgtg gcaggatgaa      300

gagtacttcg gcagctatgg aactctgaaa ctccacttgg agatgttggc agaccagcca      360

cgaacaacta aataccacag tgtcatcctg cagaataaag aatccctgac ggataaagtc      420

atcctggacg tgggctgtgg gactgggatc atcagtctct tctgtgcaca ctatgcgcgg      480

cctagagcgg tgtacgcggt ggaggccagt gagatggcac agcacacggg gcagctggtc      540

ctgcagaacg gctttgctga catcatcacc gtgtaccagc agaaggtgga ggatgtggtg      600

ctgcccgaga aggtggacgt gctggtgtct gagtggatgg ggacctgcct gctgtttgag      660

ttcatgatcg agtccatcct gtatgcccgg gatgcctggc tgaaggagga cggggtcatt      720

tggcccacca tggctgcgtt gcaccttgtg ccctgcagtg ctgataagga ttatcgtagc      780

aaggtgctct tctgggacaa cgcgtacgag ttcaacctca gcgctctgaa atctttagca      840

gttaaggagt ttttttcaaa gcccaagtat aaccacattt tgaaaccaga agactgtctc      900

tctgaaccgt gcactatatt gcagttggac atgagaaccg tgcaaatttc tgatctagag      960

accctgaggg gcgagctgcg cttcgacatc aggaaggcgg ggaccctgca cggcttcacg     1020

gcctggttta gcgtccactt ccagagcctg caggaggggc agccgccgca ggtgctcagc     1080

accgggccct tccaccccac cacacactgg aagcagacgc tgttcatgat ggacgaccca     1140

gtccctgtcc atacaggaga cgtggtcacg ggttcagttg tgttgcagag aaacccagtg     1200

tggagaaggc acatgtctgt ggctctgagc tgggctgtca cttccagaca agaccccaca     1260

tctcaaaaag ttggagaaaa agtcttcccc atctggagat ga                        1302


<210>  459
<211>  1362
<212>  DNA
<213>  Homo sapiens;

<400>  459
atggaggact acctgcaggg ttgtcgagct gctctgcagg agtcccgacc tctacatgtt       60

gtgctgggaa atgaagcctg tgatttggac tccacagtgt ctgctcttgc cctggctttt      120

tacctagcaa agacaactga ggctgaggaa gtctttgtgc cagttttaaa tataaaacgt      180

tctgaactac ctctgcgagg tgacattgtc ttctttcttc agaaggttca tattccagag      240

agtatcttga tttttcggga tgagattgac ctccatgcat tataccaggc tggccaactc      300

accctcatcc ttgtcgacca tcatatctta tccaaaagtg acacagccct agaggaggca      360

gtagcagagg tgctagacca tcgacccatc gagccgaaac actgccctcc ctgccatgtt      420

tcagttgagc tggtggggtc ctgtgctacc ctggtgaccg agagaatcct gcagggggca      480

ccagagatct tggacaggca aactgcagcc cttctgcatg gaaccatcat cctggactgt      540

gtcaacatgg accttaaaat tggaaaggca accccaaagg acagcaaata tgtggagaaa      600

ctagaggccc ttttcccaga cctacccaag agaaatgata tatttgattc cctacaaaag      660

gcaaagtttg atgtatcagg actgaccact gagcagatgc tgagaaaaga ccagaagact      720

atctatagac aaggcgtcaa ggtggccatt agtgcaatat atatggattt ggaggccttt      780

ctgcagaggt ctaacctcct tgcagatctc catgctttct gccaggctca cagctatgat      840

gtcctggttg ccatgactat ctttttcaac actcacaatg agccagtgcg gcagttggct      900

attttctgtc cccatgtggc actccaaaca acgatctgtg aagtcctgga acgctcccac      960

tctccacccc tgaagctgac ccctgcctca agtacccacc ctaacctcca tgcctatctt     1020

caaggcaaca cccaggtctc tcgaaagaaa cttctgcccc tgctccagga agccctgtca     1080

gcatattttg actccatgaa gatcccttca ggacagcctg agacagcaga tgtgtccagg     1140

gagcaagtgg acaaggaatt ggacagggca agtaactccc tgatttctgg cctgagtcaa     1200

gatgaggagg accctccgct gcccccgacg cccatgaaca gcttggtgga tgagtgccct     1260

ctagatcagg ggctgcctaa actctctgct gaggccgtct tcgagaagtg cagtcagatc     1320

tcactgtcac agtctaccac agcctccctg tccaagaagt ga                        1362


<210>  460
<211>  1575
<212>  DNA
<213>  Homo sapiens;

<400>  460
atgtacgccc tcttcctcct ggccagcctc ctgggcgcgg ctctagccgg cccggtcctt       60

ggactgaaag aatgcaccag gggctcggca gtgtggtgcc agaatgtgaa gacggcgtcc      120

gactgcgggg cagtgaagca ctgcctgcag accgtttgga acaagccaac agtgaaatcc      180

cttccctgcg acatatgcaa agacgttgtc accgcagctg gtgatatgct gaaggacaat      240

gccactgagg aggagatcct tgtttacttg gagaagacct gtgactggct tccgaaaccg      300

aacatgtctg cttcatgcaa ggagatagtg gactcctacc tccctgtcat cctggacatc      360

attaaaggag aaatgagccg tcctggggag gtgtgctctg ctctcaacct ctgcgagtct      420

ctccagaagc acctagcaga gctgaatcac cagaagcagc tggagtccaa taagatccca      480

gagctggaca tgactgaggt ggtggccccc ttcatggcca acatccctct cctcctctac      540

cctcaggacg gcccccgcag caagccccag ccaaaggata atggggacgt ttgccaggac      600

tgcattcaga tggtgactga catccagact gctgtacgga ccaactccac ctttgtccag      660

gccttggtgg aacatgtcaa ggaggagtgt gaccgcctgg gccctggcat ggccgacata      720

tgcaagaact atatcagcca gtattctgaa attgctatcc agatgatgat gcacatgcaa      780

cccaaggaga tctgtgcgct ggttgggttc tgtgatgagg tgaaagagat gcccatgcag      840

actctggtcc ccgccaaagt ggcctccaag aatgtcatcc ctgccctgga actggtggag      900

cccattaaga agcacgaggt cccagcaaag tctgatgttt actgtgaggt gtgtgaattc      960

ctggtgaagg aggtgaccaa gctgattgac aacaacaaga ctgagaaaga aatactcgac     1020

gcttttgaca aaatgtgctc gaagctgccg aagtccctgt cggaagagtg ccaggaggtg     1080

gtggacacgt acggcagctc catcctgtcc atcctgctgg aggaggtcag ccctgagctg     1140

gtgtgcagca tgctgcacct ctgctctggc acgcggctgc ctgcactgac cgttcacgtg     1200

actcagccaa aggacggtgg cttctgcgaa gtgtgcaaga agctggtggg ttatttggat     1260

cgcaacctgg agaaaaacag caccaagcag gagatcctgg ctgctcttga gaaaggctgc     1320

agcttcctgc cagaccctta ccagaagcag tgtgatcagt ttgtggcaga gtacgagccc     1380

gtgctgatcg agatcctggt ggaggtgatg gatccttcct tcgtgtgctt gaaaattgga     1440

gcctgcccct cggcccataa gcccttgttg ggaactgaga agtgtatatg gggcccaagc     1500

tactggtgcc agaacacaga gacagcagcc cagtgcaatg ctgtcgagca ttgcaaacgc     1560

catgtgtgga actag                                                      1575


<210>  461
<211>  1404
<212>  DNA
<213>  Homo sapiens;

<400>  461
atgacagagt tacctgcacc gttgtcctac ttccagaatg cacagatgtc tgaggacaac       60

cacctgagca atactgtacg tagccagaat gacaatagag aacggcagga gcacaacgac      120

agacggagcc ttggccaccc tgagccatta tctaatggac gaccccaggg taactcccgg      180

caggtggtgg agcaagatga ggaagaagat gaggagctga cattgaaata tggcgccaag      240

catgtgatca tgctctttgt ccctgtgact ctctgcatgg tggtggtcgt ggctaccatt      300

aagtcagtca gcttttatac ccggaaggat gggcagctaa tctatacccc attcacagaa      360

gataccgaga ctgtgggcca gagagccctg cactcaattc tgaatgctgc catcatgatc      420

agtgtcattg ttgtcatgac tatcctcctg gtggttctgt ataaatacag gtgctataag      480

gtcatccatg cctggcttat tatatcatct ctattgttgc tgttcttttt ttcattcatt      540

tacttggggg aagtgtttaa aacctataac gttgctgtgg actacattac tgttgcactc      600

ctgatctgga attttggtgt ggtgggaatg atttccattc actggaaagg tccacttcga      660

ctccagcagg catatctcat tatgattagt gccctcatgg ccctggtgtt tatcaagtac      720

ctccctgaat ggactgcgtg gctcatcttg gctgtgattt cagtatatga tttagtggct      780

gttttgtgtc cgaaaggtcc acttcgtatg ctggttgaaa cagctcagga gagaaatgaa      840

acgctttttc cagctctcat ttactcctca acaatggtgt ggttggtgaa tatggcagaa      900

ggagacccgg aagctcaaag gagagtatcc aaaaattcca agtataatgc agaaagcaca      960

gaaagggagt cacaagacac tgttgcagag aatgatgatg gcgggttcag tgaggaatgg     1020

gaagcccaga gggacagtca tctagggcct catcgctcta cacctgagtc acgagctgct     1080

gtccaggaac tttccagcag tatcctcgct ggtgaagacc cagaggaaag gggagtaaaa     1140

cttggattgg gagatttcat tttctacagt gttctggttg gtaaagcctc agcaacagcc     1200

agtggagact ggaacacaac catagcctgt ttcgtagcca tattaattgg tttgtgcctt     1260

acattattac tccttgccat tttcaagaaa gcattgccag ctcttccaat ctccatcacc     1320

tttgggcttg ttttctactt tgccacagat tatcttgtac agccttttat ggaccaatta     1380

gcattccatc aattttatat ctag                                            1404


<210>  462
<211>  1251
<212>  DNA
<213>  Homo sapiens;

<400>  462
atgatgcccc agctgcagtt caaagatgcc ttttggtgca gggacttcac agcccacacg       60

ggctacgagg tgctgctgca gcggcttctg gatggcagga agatgtgcaa agacatggag      120

gagctactga ggcagagggc ccaggcggag gagcggtacg ggaaggagct ggtgcagatc      180

gcacggaagg caggtggcca gacggagatc aactccctga gggcctcctt tgactccttg      240

aagcagcaaa tggagaatgt gggcagctca cacatccagc tggccctgac cctgcgtgag      300

gagctgcgga gtctcgagga gtttcgtgag aggcagaagg agcagaggaa gaagtatgag      360

gccgtcatgg accgggtcca gaagagcaag ctgtcgctct acaagaaggc catggagtcc      420

aagaagacat acgagcagaa gtgccgggac gcggacgacg cggagcaggc cttcgagcgc      480

attagcgcca acggccacca gaagcaggtg gagaagagtc agaacaaagc caggcagtgc      540

aaggactcgg ccaccgaggc agagcgggta tacaggcaga gcattgcgca gctggagaag      600

gtccgggctg agtgggagca ggagcaccgg accacctgtg aggcctttca gctgcaagag      660

tttgaccggc tgaccattct ccgcaacgcc ctgtgggtgc acagcaacca gctctccatg      720

cagtgtgtca aggatgatga gctctacgag gaagtgcggc tgacgctgga aggctgcagc      780

atagacgccg acatcgacag tttcatccag gccaagagca cgggcacaga gccccccgct      840

ccggtgccct accagaacta ttacgatcgg gaggtcaccc cgctgaccag cagccctggc      900

atacagccgt cctgcggcat gataaagagg ttctctggac tgctgcacgg aagtcccaag      960

accacttcgt tggcagcttc tgctgcgtcc acagagaccc tgacccccac ccccgagcgg     1020

aatgagggtg tctacacagc catcgcagtg caggagatac agggaaaccc ggcctcacca     1080

gcccaggagt accgggcgct ctacgattat acagcgcaga acccagatga gctggacctg     1140

tccgcgggag acatcctgga ggtgatcctg gaaggggagg atggctggtg gactgtggag     1200

aggaacgggc agcgtggctt cgtccctggt tcctacctgg agaagctttg a              1251


<210>  463
<211>  1029
<212>  DNA
<213>  Homo sapiens;

<400>  463
atggagccac atgactcctc ccacatggac tctgagttcc gatacactct cttcccgatt       60

gtttacagca tcatctttgt gctcggggtc attgctaatg gctacgtgct gtgggtcttt      120

gcccgcctgt acccttgcaa gaaattcaat gagataaaga tcttcatggt gaacctcacc      180

atggcggaca tgctcttctt gatcaccctg ccactttgga ttgtctacta ccaaaaccag      240

ggcaactgga tactccccaa attcctgtgc aacgtggctg gctgcctttt cttcatcaac      300

acctactgct ctgtggcctt cctgggcgtc atcacttata accgcttcca ggcagtaact      360

cggcccatca agactgctca ggccaacacc cgcaagcgtg gcatctcttt gtccttggtc      420

atctgggtgg ccattgtggg agctgcatcc tacttcctca tcctggactc caccaacaca      480

gtgcccgaca gtgctggctc aggcaacgtc actcgctgct ttgagcatta cgagaagggc      540

agcgtgccag tcctcatcat ccacatcttc atcgtgttca gcttcttcct ggtcttcctc      600

atcatcctct tctgcaacct ggtcatcatc cgtaccttgc tcatgcagcc ggtgcagcag      660

cagcgcaacg ctgaagtcaa gcgccgggcg ctgtggatgg tgtgcacggt cttggcggtg      720

ttcatcatct gcttcgtgcc ccaccacgtg gtgcagctgc cctggaccct tgctgagctg      780

ggcttccagg acagcaaatt ccaccaggcc attaatgatg cacatcaggt caccctctgc      840

ctccttagca ccaactgtgt cttagaccct gttatctact gtttcctcac caagaagttc      900

cgcaagcacc tcaccgaaaa gttctacagc atgcgcagta gccggaaatg ctcccgggcc      960

accacggata cggtcactga agtggttgtg ccattcaacc agatccctgg caattccctc     1020

aaaaattag                                                             1029


<210>  464
<211>  1212
<212>  DNA
<213>  Homo sapiens;

<400>  464
atgacagcca tcatcaaaga gatcgttagc agaaacaaaa ggagatatca agaggatgga       60

ttcgacttag acttgaccta tatttatcca aacattattg ctatgggatt tcctgcagaa      120

agacttgaag gcgtatacag gaacaatatt gatgatgtag taaggttttt ggattcaaag      180

cataaaaacc attacaagat atacaatctt tgtgctgaaa gacattatga caccgccaaa      240

tttaattgca gagttgcaca atatcctttt gaagaccata acccaccaca gctagaactt      300

atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg aagatgacaa tcatgttgca      360

gcaattcact gtaaagctgg aaagggacga actggtgtaa tgatatgtgc atatttatta      420

catcggggca aatttttaaa ggcacaagag gccctagatt tctatgggga agtaaggacc      480

agagacaaaa agggagtaac tattcccagt cagaggcgct atgtgtatta ttatagctac      540

ctgttaaaga atcatctgga ttatagacca gtggcactgt tgtttcacaa gatgatgttt      600

gaaactattc caatgttcag tggcggaact tgcaatcctc agtttgtggt ctgccagcta      660

aaggtgaaga tatattcctc caattcagga cccacacgac gggaagacaa gttcatgtac      720

tttgagttcc ctcagccgtt acctgtgtgt ggtgatatca aagtagagtt cttccacaaa      780

cagaacaaga tgctaaaaaa ggacaaaatg tttcactttt gggtaaatac attcttcata      840

ccaggaccag aggaaacctc agaaaaagta gaaaatggaa gtctatgtga tcaagaaatc      900

gatagcattt gcagtataga gcgtgcagat aatgacaagg aatatctagt acttacttta      960

acaaaaaatg atcttgacaa agcaaataaa gacaaagcca accgatactt ttctccaaat     1020

tttaaggtga agctgtactt cacaaaaaca gtagaggagc cgtcaaatcc agaggctagc     1080

agttcaactt ctgtaacacc agatgttagt gacaatgaac ctgatcatta tagatattct     1140

gacaccactg actctgatcc agagaatgaa ccttttgatg aagatcagca tacacaaatt     1200

acaaaagtct ga                                                         1212


<210>  465
<211>  1467
<212>  DNA
<213>  Homo sapiens;

<400>  465
atgtccactc ccggggtcaa ttcgtccgcc tccttgagcc ccgaccggct gaacagccca       60

gtgaccatcc cggcggtgat gttcatcttc ggggtggtgg gcaacctggt ggccatcgtg      120

gtgctgtgca agtcgcgcaa ggagcagaag gagacgacct tctacacgct ggtatgtggg      180

ctggctgtca ccgacctgtt gggcactttg ttggtgagcc cggtgaccat cgccacgtac      240

atgaagggcc aatggcccgg gggccagccg ctgtgcgagt acagcacctt cattctgctc      300

ttcttcagcc tgtccggcct cagcatcatc tgcgccatga gtgtcgagcg ctacctggcc      360

atcaaccatg cctatttcta cagccactac gtggacaagc gattggcggg cctcacgctc      420

tttgcagtct atgcgtccaa cgtgctcttt tgcgcgctgc ccaacatggg tctcggtagc      480

tcgcggctgc agtacccaga cacctggtgc ttcatcgact ggaccaccaa cgtgacggcg      540

cacgccgcct actcctacat gtacgcgggc ttcagctcct tcctcattct cgccaccgtc      600

ctctgcaacg tgcttgtgtg cggcgcgctg ctccgcatgc accgccagtt catgcgccgc      660

acctcgctgg gcaccgagca gcaccacgcg gccgcggccg cctcggttgc ctcccggggc      720

caccccgctg cctccccagc cttgccgcgc ctcagcgact ttcggcgccg ccggagcttc      780

cgccgcatcg cgggcgccga gatccagatg gtcatcttac tcattgccac ctccctggtg      840

gtgctcatct gctccatccc gctcgtggtg cgagtattcg tcaaccagtt atatcagcca      900

agtttggagc gagaagtcag taaaaatcca gatttgcagg ccatccgaat tgcttctgtg      960

aaccccatcc tagacccctg gatatatatc ctcctgagaa agacagtgct cagtaaagca     1020

atagagaaga tcaaatgcct cttctgccgc attggcgggt cccgcaggga gcgctccgga     1080

cagcactgct cagacagtca aaggacatct tctgccatgt caggccactc tcgctccttc     1140

atctcccggg agctgaagga gatcagcagt acatctcaga ccctcctgcc agacctctca     1200

ctgccagacc tcagtgaaaa tggccttgga ggcaggaatt tgcttccagg tgtgcctggc     1260

atgggcctgg cccaggaaga caccacctca ctgaggactt tgcgaatatc agagacctca     1320

gactcttcac agggtcagga ctcagagagt gtcttactgg tggatgaggc tggtgggagc     1380

ggcagggctg ggcctgcccc taaggggagc tccctgcaag tcacatttcc cagtgaaaca     1440

ctgaacttat cagaaaaatg tatataa                                         1467


<210>  466
<211>  1788
<212>  DNA
<213>  Homo sapiens;

<400>  466
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc       60

cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg      120

ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc      180

tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact      240

cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg      300

aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca      360

gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc      420

cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc      480

ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt      540

ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag      600

gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg      660

gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc      720

aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac      780

cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc      840

ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac      900

tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc      960

tacatcgcca gccagggttg tctggaggcc acggtcaatg acttctggca gatggcgtgg     1020

caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa     1080

tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc     1140

aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg     1200

gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat     1260

ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag     1320

gaaagtctgc ctcacgcagg gcccatcatc gtgcactgca gcgccggcat cggccgcaca     1380

ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt     1440

gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag     1500

acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag     1560

aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc     1620

tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caaacacaag     1680

gaggatgtgt atgagaacct gcacactaag aacaagaggg aggagaaagt gaagaagcag     1740

cggtcagcag acaaggagaa gagcaagggt tccctcaaga ggaagtga                  1788


<210>  467
<211>  2103
<212>  DNA
<213>  Homo sapiens;

<400>  467
atggagccct tgtgtccact cctgctggtg ggttttagct tgccgctcgc cagggctctc       60

aggggcaacg agaccactgc cgacagcaac gagacaacca cgacctcagg ccctccggac      120

ccgggcgcct cccagccgct gctggcctgg ctgctactgc cgctgctgct cctcctcctc      180

gtgctccttc tcgccgccta cttcttcagg ttcaggaagc agaggaaagc tgtggtcagc      240

accagcgaca agaagatgcc caacggaatc ttggaggagc aagagcagca aagggtgatg      300

ctgctcagca ggtcaccctc agggcccaag aagtattttc ccatccccgt ggagcacctg      360

gaggaggaga tccgtatcag atccgccgac gactgcaagc agtttcggga ggagttcaac      420

tcattgccat ctggacacat acaaggaact tttgaactgg caaataaaga agaaaacaga      480

gaaaaaaaca gatatcccaa catccttccc aatgaccatt ctagggtgat tctgagccaa      540

ctggatggaa ttccctgttc agactacatc aatgcttcct acatagatgg ttacaaagag      600

aagaataaat tcatagcagc tcaaggtccc aaacaggaaa cggttaacga cttctggaga      660

atggtctggg agcaaaagtc tgcgaccatc gtcatgttaa caaacttgaa agaaaggaaa      720

gaggaaaagt gccatcagta ctggcccgac caaggctgct ggacctatgg aaacatccgg      780

gtgtgcgtgg aggactgcgt ggttttggtc gactacacca tccggaagtt ctgcatacag      840

ccacagctcc ccgacggctg caaagccccc aggctggtct cacagctgca cttcaccagc      900

tggcccgact tcggagtgcc ttttaccccc attgggatgc tgaagttcct caagaaagta      960

aagacgctca accccgtgca cgctgggccc atcgtggtcc actgtagcgc gggcgtgggc     1020

cggacgggca ccttcattgt gatcgatgcc atgatggcca tgatgcacgc ggagcagaag     1080

gtggatgtgt ttgaatttgt gtctcgaatc cgtaatcagc gccctcagat ggttcaaacg     1140

gatatgcagt acacgttcat ctaccaagcc ttactcgagt actacctcta cggggacaca     1200

gagctggacg tgtcctccct ggagaagcac ctgcagacca tgcacggcac caccacccac     1260

ttcgacaaga tcgggctgga ggaggagttc aggaaattga caaatgtccg gatcatgaag     1320

gagaacatga ggacgggcaa cttgccggca aacatgaaga aggccagggt catccagatc     1380

atcccgtatg acttcaaccg agtgatcctt tccatgaaaa ggggtcaaga atacacagac     1440

tacatcaacg catccttcat agacggctac cgacagaagg actatttcat cgccacccag     1500

gggccactgg cacacacggt tgaggacttc tggaggatga tctgggaatg gaaatcccac     1560

actatcgtga tgctgacgga ggtgcaggag agagagcagg ataaatgcta ccagtattgg     1620

ccaaccgagg gctcagttac tcatggagaa ataacgattg agataaagaa tgataccctt     1680

tcagaagcca tcagtatacg agactttctg gtcactctca atcagcccca ggcccgccag     1740

gaggagcagg tccgagtagt gcgccagttt cacttccacg gctggcctga gatcgggatt     1800

cccgccgagg gcaaaggcat gattgacctc atcgcagccg tgcagaagca gcagcagcag     1860

acaggcaacc accccatcac cgtgcactgc agtgccggag ctgggcgaac aggtacattc     1920

atagccctca gcaacatttt ggagcgagta aaagccgagg gacttttaga tgtatttcaa     1980

gctgtgaaga gtttacgact tcagagacca catatggtgc aaaccctgga acagtatgaa     2040

ttctgctaca aagtggtaca agattttatt gatatatttt ctgattatgc taatttcaaa     2100

tga                                                                   2103


<210>  468
<211>  3195
<212>  DNA
<213>  Homo sapiens;

<400>  468
atgaatcatg attttcaagc tcttgcatta gaatctcggg gaatgggaga gcttttgcct       60

accaaaaagt tttgggaacc tgatgattca acaaaagatg gacaaaaagg catatttctt      120

ggggatgatg aatggagaga gactgcatgg ggagcttctc accattcaat gtcccagcct      180

attatggtac agagaagatc tggacagggt tttcatggaa acagtgaagt aaatgcaata      240

ctgtctccgc gatcagaaag tggaggcctt ggtgtgagca tggtagaata tgtattaagt      300

tcttctcctg ctgataaatt ggattctcga tttaggaagg gaaattttgg cactagagat      360

gctgaaacag atggacctga gaaaggagat caaaaaggca aggcttctcc atttgaggag      420

gaccaaaaca gagatcttaa acaaggagat gatgatgatt ctaaaataaa tggcagaggt      480

ttgccaaatg gaatggatgc cgattgcaaa gattttaatc gtactcctgg aagtcgtcaa      540

gcctctccaa ctgaagtagt tgagcgcttg ggccccaata ctaatccctc agaaggactg      600

gggcctcttc ctaatcctac agctaataaa ccacttgttg aagaattttc aaatcctgaa      660

actcagaatc tggatgccat ggaacaagtt ggtctggaat ccttacagtt tgactatcct      720

ggtaatcagg taccaatgga ctcttcagga gctactgtag gcctttttga ctacaattcc      780

cagcagcagc tctttcagag gactaatgca ctaacagttc aacagttaac tgcagctcaa      840

cagcagcaat atgcattagc agcagctcag cagccacata tagctggtgt attctcagca      900

ggccttgctc cagctgcatt tgtgccaaat ccatacatta ttagtgctgc tcctccaggg      960

accgatccgt atactgcagc aggattggct gcagcagcta cattagcagg tccagcagtg     1020

gttccacctc agtattacgg cgttccatgg ggggtgtatc cagccaactt atttcagcag     1080

caagctgcag ctgcggcaaa taacacagcc agtcagcaag cagcatcaca agctcagcct     1140

ggacagcaac aggttctccg tgctggagca ggtcagcgtc ctcttactcc caatcagggt     1200

cagcaagggc agcaagcaga atcacttgcg gcagctgcag cagcaaatcc aacattggct     1260

tttggtcagg gtcttgctac tggcatgcca ggctatcaag tactagctcc aactgcctat     1320

tatgatcaga ctggtgcctt agtggttggc cctggagcaa ggactggcct tggagctcca     1380

gttcggttaa tggctccaac acctgtttta attagttcag cagcagcaca agctgcagca     1440

gcagcagcag ctggaggaac tgcaagtagc cttacaggca gcacaaatgg tctgtttcgg     1500

ccaattggca ctcagccacc acagcagcag caacagcagc caagcactaa tctgcaatct     1560

aattcatttt atggaagcag ttctttgact aatagctccc agagtagttc tttattttct     1620

catggacctg gtcaacctgg aagtacatct cttggctttg gaagtggtaa ctctttgggt     1680

gctgctatag gctcagccct cagtggattt ggttcatcag ttggcagttc tgcaagtagt     1740

agtgccacaa ggagagagtc tctatctact agctctgact tgtacaaaag atctagtagc     1800

agcctagcac ccatagggca accattttac aatagtctgg gattttcctc ctctccaagt     1860

ccaataggca tgcctctgcc aagccaaact ccaggacatt cacttacgcc accgccatca     1920

ctttcatcac atggatcctc atccagtttg catttaggag gactgacaaa tggtagtggt     1980

cgatatatct ctgcagcacc tggagcagaa gcaaaatatc gaagtgcttc aagcacttcc     2040

agtctattta gctccagcag ccagctcttt cctccttccc ggcttcggta taataggtct     2100

gatattatgc cttctggccg cagtagatta ttggaagatt tcagaaacaa ccgcttccca     2160

aaccttcagc ttagagactt gattggacat atagttgagt tttctcaaga ccagcatggt     2220

tctagattca tacagcaaaa actagagaga gctactccag ctgagcgaca gatggtattt     2280

aatgaaattc tgcaagcagc ctatcaatta atgactgatg tttttggcaa ctatgttata     2340

cagaagtttt ttgagtttgg gagtctggat caaaaattag ccctggctac tcgtattcgt     2400

ggtcatgttc tacccttagc cttgcagatg tatggctgcc gcgttattca gaaagcatta     2460

gaatctattt cttctgacca gcagagtgaa atggtaaagg agctggatgg tcatgtgctc     2520

aaatgtgtga aagatcagaa tggaaaccat gttgtacaaa aatgtatcga atgtgttcag     2580

ccacagtcac tacagttcat cattgatgct ttcaagggac aagtatttgt gctttcaact     2640

catccttatg gctgcagagt aattcagcgc atcctagagc attgcactgc agaacagacc     2700

ttacctatct tagaagaact ccaccaacat acagagcagt tggtacagga tcagtatggc     2760

aattatgtta ttcagcatgt actggaacac ggtcgacctg aagacaagag caaaattgtt     2820

tccgaaatca ggggaaaggt tttagccctg agtcaacaca aatttgccag caatgtagta     2880

gaaaagtgtg ttactcatgc ctcccgtgct gagagagctt tactgattga cgaggtttgc     2940

tgccagaatg atggtcctca cagtgcctta tacaccatga tgaaggacca gtatgccaat     3000

tacgtggttc aaaagatgat tgatatggct gaacctgctc agagaaagat aatcatgcac     3060

aagattcgac ctcacattac tactttgcgc aaatacacat acgggaagca tatactggcc     3120

aagttggaaa agtattattt gaagaatagc ccggacctag gacctattgg aggaccacca     3180

aatggaatgc tgtaa                                                      3195


<210>  469
<211>  2931
<212>  DNA
<213>  Homo sapiens;

<400>  469
atgtctaaca gtaacactac tcaagagacc ctggaaataa tgaaagaatc agaaaaaaaa       60

ctggtggaag aatctgtaaa caaaaacaag tttatatcta agactccaag taaggaagaa      120

attgagaaag aatgtgaaga taccagtttg cgtcaggaga cacagaggcg gacatctaac      180

catggtcatg ccaggaaaag agccaagtct aattccaagc taaagttggt gcgtagcctg      240

gcagtgtgtg aggagtcctc caccccattt gctgatgggc cattagaaac ccaggatata      300

attcaattgc acatcagttg cccttctgac aaggaggaag aaaagtccac aaaagatgtc      360

tctgaaaagg aagacaagga caaaaacaaa gaaaagatcc caaggaagat gctgtccaga      420

gactccagcc aggaatatac ggactccact ggaatagacc tacatgaatt tcttgtaaat      480

acactgaaaa agaacccaag ggacagaatg atgctgctaa aattagaaca ggagattctg      540

gaatttatta atgacaacaa taatcagttc aagaagttcc ctcagatgac ctcatatcac      600

cggatgctat tacaccgggt agctgcctat tttgggatgg accacaatgt tgatcaaact      660

gggaaagctg tcatcatcaa caaaactagt aacacaagaa tccctgaaca gaggttctca      720

gaacatataa aggatgagaa gaatacagaa tttcaacaga ggttcattct caagagagat      780

gatgccagta tggaccgaga tgataaccag actggccaga acggatatct aaatgacatc      840

agactctcca aagaagcctt ttcttctagc tctcacaaga gaaggcagat ttttaggggg      900

aaccgtgaag gactgagccg cacctcaagc agccgccaga gcagcacaga cagcgaactc      960

aaatccctgg agccacgccc ttggagcagc acagactctg atggctctgt ccggagcatg     1020

cgaccccctg tcaccaaagc tagcagcttc agtggaatct ctatccttac ccgaggtgac     1080

agcatcggca gcagtaaagg cggcagtgcg ggaaggatct ccaggccagg tatggcacta     1140

ggtgccccag aagtgtgcaa ccaggtcacc tcatcccagt ctgtccgggg gcttctccct     1200

tgtactgccc agcagcaaca gcagcagcag cagcagcaac ttcctgctct cccacccacg     1260

cctcagcaac agccaccctt gaataatcac atgatctcac aggcagatga cctcagcaac     1320

ccctttggac aaatgagcct tagtcgccaa ggttctactg aagcagctga cccatctgca     1380

gctctattcc agaccccact tatctcccag caccctcagc agactagctt catcatggct     1440

tccacgggtc agcccctccc cacttccaac tattccacct ctagccatgc accacctact     1500

cagcaagttc tgccacccca ggggtacatg cagccccctc aacagatcca ggtttcttac     1560

tatccccctg gacaatatcc taactccaac cagcaatatc gacctctctc tcacccggtg     1620

gcctatagcc cccaacgtgg tcagcagctg cctcagccat cccagcagcc tggtttacag     1680

cccatgatgc ctaaccagca gcaggcggct taccaaggca tgattggggt ccagcagcca     1740

cagaaccagg gcctgctcag cagccagagg agcagcatgg ggggccagat gcaaggcctg     1800

gtggttcagt acactccact gccttcttac caagttccag tgggtagtga ctcgcaaaat     1860

gtggtccagc cgcctttcca gcaacccatg ctggtccctg tgagccagtc tgtgcaagga     1920

ggcctcccag cagcgggggt accagtgtac tatagcatga tcccacctgc tcagcagaac     1980

ggtacgagcc cttctgtagg gtttctgcaa ccccctggct ctgagcagta ccagatgcct     2040

cagtctccct ctccctgcag tccaccacag atgccacagc agtactcagg agtgtcacct     2100

tctggaccag gtgtagtggt catgcagctg aatgtcccta atggacccca gccccctcag     2160

aacccatcca tggtccagtg gagtcattgt aaatactaca gcatggacca gcgggggcag     2220

aagcctggag acctgtacag tcctgacagc agcccccagg ccaacacaca aatgagcagc     2280

agccctgtca catctcctac ccagtctcca gcaccctctc ctgtcaccag cctcagcagt     2340

gtctgcacag gactcagtcc cctgcctgtc ctcacacagt tcccccggcc tgggggtcca     2400

gcacagggtg atgggcgcta ctcccttttg ggccagccat tacagtacaa tctgtccatc     2460

tgccctccct tgctccatgg ccagtcaact tacacggtgc accagggaca gagtggactg     2520

aagcatggaa accggggcaa gagacaagca ctcaaatctg cctccactga cctggggaca     2580

gcagatgttg tcctggggcg ggtgctggag gtgacagatc tccctgaggg catcacccgt     2640

actgaggcgg acaaactctt cacgcagctc gccatgtctg gcgccaagat ccagtggctc     2700

aaggatgctc aggggctgcc tggagggggt gggggggaca acagtgggac tgctgagaat     2760

ggccgccact cggacctcgc tgccttgtac accattgtgg ctgtgttccc cagccccctg     2820

gctgcccaaa atgcctccct tcgtctcaac aactccgtga gtcgcttcaa acttcgaatg     2880

gccaaaaaga actatgacct gaggatcctg gagcgagcca gctcccaata a              2931


<210>  470
<211>  1950
<212>  DNA
<213>  Homo sapiens;

<400>  470
atgtccctaa tggtctcggc tggccggggc ctgggggccg tgtggtcccc aacccacgtg       60

caggtgacgg tgctgcaggc gcggggcctg cgggccaagg gccccggggg cacgagcgac      120

gcgtacgcgg tgatccaggt gggcaaggag aagtacgcca cctccgtgtc ggagcgcagc      180

ctgggcgcgc ccgtgtggcg cgaggaggcc accttcgagc tgccatcgct gctgtcctcc      240

ggacccgcgg ccgccgccac cctgcagctc accgtgctgc accgcgcgct gctcggcctc      300

gacaagttcc tgggccgcgc cgaggtggac ctgcgggatc tgcaccgcga ccagggccgc      360

aggaagacgc agtggtataa gttgaaatcc aaaccaggaa agaaggacaa ggagcgagga      420

gaaattgagg ttgacatcca gtttatgaga aacaacatga ctgccagcat gtttgacctt      480

tctatgaaag acaagtctcg gaatccattt ggaaagctga aggacaagat caaggggaag      540

aataaggaca gtgggtcaga caccgcctcc gccatcatcc ctagcacgac accttcggtc      600

gacagtgatg atgagtctgt ggttaaagac aagaaaaaga aatcaaagat caagacctta      660

ctttccaagt caaatttgca gaagacgcct ctttcccagt ccatgtctgt cctgccgact      720

tcaaagccag aaaaagtgct gcttcgtccc ggagactttc agtcccagtg ggatgaagat      780

gacaatgagg atgagtcctc ctcggcctcg gatgtcatgt ctcacaagag aacagcgagt      840

acggatctta agcaactgaa ccaggtcaac tttacccttc ccaagaagga aggactttcc      900

tttcttggtg gccttcggtc taagaatgat gtcctttccc gctctaatgt ctgcatcaat      960

gggaaccatg tttacctgga gcagccagaa gccaagggtg agatcaagga tagcagcccg     1020

tcctcctccc catcccccaa gggcttcaga aagaagcatt tgttctcttc tacagagaac     1080

ctggcggctg ggtcttggaa ggagcctgct gaaggaggtg ggctgtcttc tgacaggcag     1140

ctctccgaat cttccaccaa ggactccttg aagtctatga ccctgccgtc ctaccgacct     1200

gccccactgg tcagtgggga cctcagggaa aacatggccc ccgcaaactc agaggccaca     1260

aaagaagcta aggagagcaa gaagccagag agcaggaggt cctctttgct gtctctgatg     1320

acggggaaga aggatgtggc taagggcagt gaaggtgaaa accctctcac ggtcccaggg     1380

agggagaagg aaggcatgct gatgggggtt aagccggggg aggacgcatc ggggcctgct     1440

gaagaccttg tgagaagatc tgagaaagat actgcagctg ttgtctccag acagggcagc     1500

tccctgaacc tctttgaaga tgtgcagatc acagaaccag aagctgagcc agagtccaag     1560

tctgaaccga gacctccaat ttcctctccg agggctcccc agaccagagc tgtcaagccc     1620

cgacttcatc ctgtgaagcc aatgaatgca atggccacca aggttgctaa ctgcagcttg     1680

ggaactgcca ccatcatcag tgagaacttg aacaatgagg tcatgatgaa gaaatacagc     1740

ccctcggacc ctgcatttgc atatgcgcag ctgacccacg atgagctgat tcagctggtc     1800

ctcaaacaga aggaaacgat aagcaagaag gagttccagg tccgcgagct ggaagactac     1860

attgacaacc tgcttgtcag ggtcatggaa gaaaccccca atatcctccg catcccgact     1920

caggttggca aaaaagcagg aaagatgtaa                                      1950


<210>  471
<211>  648
<212>  DNA
<213>  Homo sapiens;

<400>  471
atggcaactg caccatacaa ctactcttac atctttaaat atattattat tggggacatg       60

ggagtaggaa aatcttgctt gcttcatcaa tttacagaaa aaaaatttat ggctgattgt      120

cctcacacaa ttggtgttga atttggtaca agaataatcg aagttagtgg ccaaaaaata      180

aaactgcaga tttgggatac ggcaggacag gagcgattta gggctgttac acggagctac      240

tacagaggag ctgcgggagc tcttatggtc tatgatatca ctagaagaag tacatataac      300

cacttaagca gctggttgac agatgcaagg aatctcacca atccaaatac tgtaataatt      360

ctcataggaa ataaagcaga tttggaggca cagagagatg ttacatatga agaagccaaa      420

cagtttgctg aagaaaatgg cttattgttc ctcgaagcga gtgcaaaaac gggagagaat      480

gtagaagatg ccttccttga ggctgccaag aaaatctatc agaacattca ggatggaagc      540

ttggatctga atgctgctga gtctggtgta caacacaaac cttcagcccc gcagggaggc      600

cggctaacca gtgaacccca accccagaga gaaggctgtg gctgctag                   648


<210>  472
<211>  588
<212>  DNA
<213>  Homo sapiens;

<400>  472
atgatggcga tacgggagct caaagtgtgc cttctcgggg acactggggt tgggaaatca       60

agcatcgtgt gtcgatttgt ccaggatcac tttgaccaca acatcagccc tactattggg      120

gcatctttta tgaccaaaac tgtgccttgt ggaaatgaac ttcacaagtt cctcatctgg      180

gacactgctg gtcaggaacg gtttcattca ttggctccca tgtactatcg aggctcagct      240

gcagctgtta tcgtgtatga tattaccaag caggattcat tttatacctt gaagaaatgg      300

gtcaaggagc tgaaagaaca tggtccagaa aacattgtaa tggccatcgc tggaaacaag      360

tgcgacctct cagatattag ggaggttccc ctgaaggatg ctaaggaata cgctgaatcc      420

ataggtgcca tcgtggttga gacaagtgca aaaaatgcta ttaatatcga agagctcttt      480

caaggaatca gccgccagat cccacccttg gacccccatg aaaatggaaa caatggaaca      540

atcaaagttg agaagccaac catgcaagcc agccgccggt gctgttga                   588


<210>  473
<211>  642
<212>  DNA
<213>  Homo sapiens;

<400>  473
atggctgaga cctacgactt cctcttcaaa ttcctggtga ttggcagtgc aggaactggc       60

aaatcatgtc tccttcatca gttcattgag aataagttca aacaggactc caaccacaca      120

atcggcgtgg agtttggatc ccgggtggtc aacgtgggtg ggaagactgt gaagctacag      180

atttgggaca cggctggcca ggagcggttt cggtcagtga cgcggagtta ttaccgaggg      240

gcggctggag ccctgctggt gtacgacatc accagccggg agacatacaa ctcactggct      300

gcctggctga cggatgcccg caccctggcc agccccaaca tcgtggtcat cctctgtggc      360

aacaagaagg acctggaccc tgagcgggag gtcactttcc tggaggcctc ccgctttgcc      420

caggagaatg agctgatgtt cctggagacc agcgctctca caggcgagaa cgtggaggag      480

gcgttcctca agtgtgcccg cactatcctc aacaagattg actcaggcga gctagacccg      540

gagaggatgg gctctggcat tcagtacggg gatgcgtccc tccgccagct tcggcagcct      600

cggagtgccc aggccgtggc ccctcagccg tgtggctgct ga                         642


<210>  474
<211>  624
<212>  DNA
<213>  Homo sapiens;

<400>  474
atgacctcta ggaagaaagt gttgctgaag gttatcatcc tgggagattc tggagtcggg       60

aagacatcac tcatgaacca gtatgtgaat aagaaattca gcaatcagta caaagccaca      120

ataggagctg actttctgac caaggaggtg atggtggatg acaggctagt cacaatgcag      180

atatgggaca cagcaggaca ggaacggttc cagtctctcg gtgtggcctt ctacagaggt      240

gcagactgct gcgttctggt atttgatgtg actgccccca acacattcaa aaccctagat      300

agctggagag atgagtttct catccaggcc agtccccgag atcctgaaaa cttcccattt      360

gttgtgttgg gaaacaagat tgacctcgaa aacagacaag tggccacaaa gcgggcacag      420

gcctggtgct acagcaaaaa caacattccc tactttgaga ccagtgccaa ggaggccatc      480

aacgtggagc aggcgttcca gacgattgca cggaatgcac ttaagcagga aacggaggtg      540

gagctgtaca acgaatttcc tgaacctatc aaactggaca agaatgaccg ggccaaggcc      600

tcggcagaaa gctgcagttg ctga                                             624


<210>  475
<211>  1947
<212>  DNA
<213>  Homo sapiens;

<400>  475
atggagcaca tacagggagc ttggaagacg atcagcaatg gttttggatt caaagatgcc       60

gtgtttgatg gctccagctg catctctcct acaatagttc agcagtttgg ctatcagcgc      120

cgggcatcag atgatggcaa actcacagat ccttctaaga caagcaacac tatccgtgtt      180

ttcttgccga acaagcaaag aacagtggtc aatgtgcgaa atggaatgag cttgcatgac      240

tgccttatga aagcactcaa ggtgaggggc ctgcaaccag agtgctgtgc agtgttcaga      300

cttctccacg aacacaaagg taaaaaagca cgcttagatt ggaatactga tgctgcgtct      360

ttgattggag aagaacttca agtagatttc ctggatcatg ttcccctcac aacacacaac      420

tttgctcgga agacgttcct gaagcttgcc ttctgtgaca tctgtcagaa attcctgctc      480

aatggatttc gatgtcagac ttgtggctac aaatttcatg agcactgtag caccaaagta      540

cctactatgt gtgtggactg gagtaacatc agacaactct tattgtttcc aaattccact      600

attggtgata gtggagtccc agcactacct tctttgacta tgcgtcgtat gcgagagtct      660

gtttccagga tgcctgttag ttctcagcac agatattcta cacctcacgc cttcaccttt      720

aacacctcca gtccctcatc tgaaggttcc ctctcccaga ggcagaggtc gacatccaca      780

cctaatgtcc acatggtcag caccaccctg cctgtggaca gcaggatgat tgaggatgca      840

attcgaagtc acagcgaatc agcctcacct tcagccctgt ccagtagccc caacaatctg      900

agcccaacag gctggtcaca gccgaaaacc cccgtgccag cacaaagaga gcgggcacca      960

gtatctggga cccaggagaa aaacaaaatt aggcctcgtg gacagagaga ttcaagctat     1020

tattgggaaa tagaagccag tgaagtgatg ctgtccactc ggattgggtc aggctctttt     1080

ggaactgttt ataagggtaa atggcacgga gatgttgcag taaagatcct aaaggttgtc     1140

gacccaaccc cagagcaatt ccaggccttc aggaatgagg tggctgttct gcgcaaaaca     1200

cggcatgtga acattctgct tttcatgggg tacatgacaa aggacaacct ggcaattgtg     1260

acccagtggt gcgagggcag cagcctctac aaacacctgc atgtccagga gaccaagttt     1320

cagatgttcc agctaattga cattgcccgg cagacggctc agggaatgga ctatttgcat     1380

gcaaagaaca tcatccatag agacatgaaa tccaacaata tatttctcca tgaaggctta     1440

acagtgaaaa ttggagattt tggtttggca acagtaaagt cacgctggag tggttctcag     1500

caggttgaac aacctactgg ctctgtcctc tggatggccc cagaggtgat ccgaatgcag     1560

gataacaacc cattcagttt ccagtcggat gtctactcct atggcatcgt attgtatgaa     1620

ctgatgacgg gggagcttcc ttattctcac atcaacaacc gagatcagat catcttcatg     1680

gtgggccgag gatatgcctc cccagatctt agtaagctat ataagaactg ccccaaagca     1740

atgaagaggc tggtagctga ctgtgtgaag aaagtaaagg aagagaggcc tctttttccc     1800

cagatcctgt cttccattga gctgctccaa cactctctac cgaagatcaa ccggagcgct     1860

tccgagccat ccttgcatcg ggcagcccac actgaggata tcaatgcttg cacgctgacc     1920

acgtccccga ggctgcctgt cttctag                                         1947


<210>  476
<211>  621
<212>  DNA
<213>  Homo sapiens;

<400>  476
atggctgcca acaagagtaa gggccagagc tccttggccc tccacaaggt gatcatggtt       60

ggcagcggag gcgttggcaa gtcagccctg acgcttcagt tcatgtatga cgagtttgta      120

gaagactatg aacctaccaa agctgacagt tatagaaaga aagtggttct tgatggggaa      180

gaagttcaga tagatattct ggacaccgct gggcaagagg actacgcagc cattcgagat      240

aactactttc ggagtgggga agggtttctt cttgtgttct caatcacaga acatgaatcc      300

tttacagcaa ctgccgaatt cagggaacag attctccgtg tgaaggctga agaagataaa      360

attccactgc tcgtcgtggg aaacaagtct gacctagagg agcggaggca ggtgcctgtg      420

gaggaggcca ggagtaaagc cgaagagtgg ggcgtgcagt acgtggagac gtcagcgaag      480

acccgggcca acgtggacaa ggtgttcttt gacctaatga gagaaatcag aacaaagaag      540

atgtcagaaa acaaagacaa gaatggcaag aaaagcagca agaacaagaa aagttttaaa      600

gaaagatgtt gcttactatg a                                                621


<210>  477
<211>  1389
<212>  DNA
<213>  Homo sapiens;

<400>  477
atggccagca acagcagctc ctgcccgaca cctgggggcg ggcacctcaa tgggtacccg       60

gtgcctccct acgccttctt cttcccccct atgctgggtg gactctcccc gccaggcgct      120

ctgaccactc tccagcacca gcttccagtt agtggatata gcacaccatc cccagccacc      180

attgagaccc agagcagcag ttctgaagag atagtgccca gccctccctc gccaccccct      240

ctaccccgca tctacaagcc ttgctttgtc tgtcaggaca agtcctcagg ctaccactat      300

ggggtcagcg cctgtgaggg ctgcaagggc ttcttccgcc gcagcatcca gaagaacatg      360

gtgtacacgt gtcaccggga caagaactgc atcatcaaca aggtgacccg gaaccgctgc      420

cagtactgcc gactgcagaa gtgctttgaa gtgggcatgt ccaaggagtc tgtgagaaac      480

gaccgaaaca agaagaagaa ggaggtgccc aagcccgagt gctctgagag ctacacgctg      540

acgccggagg tgggggagct cattgagaag gtgcgcaaag cgcaccagga aaccttccct      600

gccctctgcc agctgggcaa atacactacg aacaacagct cagaacaacg tgtctctctg      660

gacattgacc tctgggacaa gttcagtgaa ctctccacca agtgcatcat taagactgtg      720

gagttcgcca agcagctgcc cggcttcacc accctcacca tcgccgacca gatcaccctc      780

ctcaaggctg cctgcctgga catcctgatc ctgcggatct gcacgcggta cacgcccgag      840

caggacacca tgaccttctc ggacgggctg accctgaacc ggacccagat gcacaacgct      900

ggcttcggcc ccctcaccga cctggtcttt gccttcgcca accagctgct gcccctggag      960

atggatgatg cggagacggg gctgctcagc gccatctgcc tcatctgcgg agaccgccag     1020

gacctggagc agccggaccg ggtggacatg ctgcaggagc cgctgctgga ggcgctaaag     1080

gtctacgtgc ggaagcggag gcccagccgc ccccacatgt tccccaagat gctaatgaag     1140

attactgacc tgcgaagcat cagcgccaag ggggctgagc gggtgatcac gctgaagatg     1200

gagatcccgg gctccatgcc gcctctcatc caggaaatgt tggagaactc agagggcctg     1260

gacactctga gcggacagcc ggggggtggg gggcgggacg ggggtggcct ggcccccccg     1320

ccaggcagct gtagccccag cctcagcccc agctccaaca gaagcagccc ggccacccac     1380

tccccgtga                                                             1389


<210>  478
<211>  981
<212>  DNA
<213>  Homo sapiens;

<400>  478
atggactaca gccaccaaac gtccctagtc ccatgtggac aagataaata catttccaaa       60

aatgaacttc tcttgcatct gaagacctac aacttgtact atgaaggcca gaatttacag      120

ctccggcacc gggaggaaga agacgagttc attgtggagg ggctcctgaa catctcctgg      180

ggcctgcgcc ggcccattcg cctgcagatg caggatgaca acgaacgcat tcgaccccct      240

ccatcctcct cctcctggca ctctggctgt aacctggggg ctcagggaac cactctgaag      300

cccctgactg tgcccaaagt tcagatctca gaggtggatg ccccgccgga gggtgaccag      360

atgccaagct ccacagactc caggggcctg aagcccctgc aggaggacac cccacagctg      420

atgcgcacac gcagtgatgt tggggtgcgt cgccgtggca atgtgaggac gcctagtgac      480

cagcggcgaa tcagacgcca ccgcttctcc atcaacggcc atttctacaa ccataagaca      540

tccgtgttca caccagccta tggctctgtc accaacgtcc gcatcaacag caccatgacc      600

accccacagg tcctgaagct gctgctcaac aaatttaaga ttgagaattc agcagaggag      660

tttgccttgt acgtggtcca tacgagtggt gagaaacaga agctgaaggc caccgattac      720

ccgctgattg cccgaatcct ccagggccca tgtgagcaga tctccaaagt gttcctaatg      780

gagaaggacc aggtggagga agtcacctac gacgtggccc agtatataaa gttcgagatg      840

ccggtactta aaagcttcat tcagaagctc caggaggaag aagatcggga agtaaagaag      900

ctgatgcgca agtacaccgt gctccggcta atgattcgac agaggctgga ggagatagcc      960

gagaccccag caacaatctg a                                                981


<210>  479
<211>  1272
<212>  DNA
<213>  Homo sapiens;

<400>  479
atggcatctg atgactttga catagtgatt gaggccatgc tggaagctcc ctataaaaaa       60

gaagaggatg agcaacaaag gaaagaagtt aaaaaggatt atcctagcaa taccaccagc      120

agcaccagca acagtggcaa tgagaccagt ggaagcagca ccatcgggga gacaagcaat      180

cgtagtcgag atcgggatcg gtatagacgg agaaatagtc ggagccgaag tccaggtcgg      240

cagtgtcgtc accgtagccg tagctgggat cgtcgacatg gtagtgagtc gcgaagtcgg      300

gaccatcgtc gtgaggatcg tgtgcattac aggagtcctc cacttgccac tggttatagg      360

tatggacaca gtaagagtcc tcatttcaga gagaagagcc cagtcaggga gccagttgat      420

aatctgagtc ctgaggagcg tgatgcccgc acagttttct gtatgcagtt agctgcccga      480

attcggcctc gagatctgga ggactttttc tctgctgtag gcaaggttcg cgatgtacgt      540

atcatctcag atcggaactc acgtcgttct aagggcattg cctacgtgga attctgtgaa      600

atccagtctg tgccactggc cattgggctg actgggcagc ggttgctggg agtgcctatc      660

attgtacagg cttcacaggc agagaaaaac cgactggcag ccatggccaa caacctgcaa      720

aagggcaatg gtggaccaat gcgcctctat gtgggttccc tgcacttcaa tatcactgaa      780

gacatgctcc ggggcatctt tgagcccttt ggtaaaattg ataatattgt cctgatgaag      840

gactcagata caggccgctc taaaggttat ggtttcatca cgttctctga ttctgagtgt      900

gcccggcggg ccctggaaca gttgaatggg tttgagcttg ctggtcgacc tatgagggtt      960

ggccatgtga ctgagcgact ggatggtggc acagacatca cttttcctga tggggaccag     1020

gagctggatc tgggatcagc aggtggacgt tttcagctca tggcaaaact ggcagaaggc     1080

gctggaatcc aactgccaag cactgctgct gctgctgctg ccgccgccgc ccaggctgct     1140

gccttgcaac tgaatggagc agttcccttg ggggccctga atccagcagc tctgactgct     1200

ctgagtccag ccctgaacct tgcctcccag tgtttccagc tctccagcct ctttaccccc     1260

cagaccatgt aa                                                         1272


<210>  480
<211>  1221
<212>  DNA
<213>  Homo sapiens;

<400>  480
atgggcaaag tgtggaaaca gcagatgtac cctcagtacg ccacctacta ttacccccag       60

tatctgcaag ccaagcagtc tctggtccca gcccacccca tggcccctcc cagtcccagc      120

accaccagca gtaataacaa cagtagcagc agtagcaact caggatggga tcagctcagc      180

aaaacgaacc tctatatccg aggactgcct ccccacacca ccgaccagga cctggtgaag      240

ctctgtcaac catatgggaa aatagtctcc acaaaggcaa ttttggataa gacaacgaac      300

aaatgcaaag gttatggttt tgtcgacttt gacagccctg cagcagctca aaaagctgtg      360

tctgccctga aggccagtgg ggttcaagct caaatggcaa agcaacagga acaagatcct      420

accaacctct acatttctaa tttgccactc tccatggatg agcaagaact agaaaatatg      480

ctcaaaccat ttggacaagt tatttctaca aggatactac gtgattccag tggtacaagt      540

cgtggtgttg gctttgctag gatggaatca acagaaaaat gtgaagctgt tattggtcat      600

tttaatggaa aatttattaa gacaccacca ggagtttctg cccccacaga acctttattg      660

tgtaagtttg ctgatggagg acagaaaaag agacagaacc caaacaaata catccctaat      720

ggaagaccat ggcatagaga aggagaggtg agacttgctg gaatgacact tacttacgac      780

ccaactacag ctgctataca gaacggattt tatccttcac catacagtat tgctacaaac      840

cgaatgatca ctcaaacttc tattacaccc tatattgcat ctcctgtatc tgcctaccag      900

gtgcaaagtc cttcgtggat gcaacctcaa ccatatattc tacagcaccc tggtgccgtg      960

ttaactccct caatggagca caccatgtca ctacagcccg catcaatgat cagccctctg     1020

gcccagcaga tgagtcatct gtcactaggc agcaccggaa catacatgcc tgcaacgtca     1080

gctatgcaag gagcctactt gccacagtat gcacatatgc agacgacagc ggttcctgtt     1140

gaggaggcaa gtggtcaaca gcaggtggct gtcgagacgt ctaatgacca ttctccatat     1200

acctttcaac ctaataagta a                                               1221


<210>  481
<211>  3195
<212>  DNA
<213>  Homo sapiens;

<400>  481
atgcctgtgc aggcagctca atggacagaa tttctgtcct gtccaatctg ctataatgaa       60

tttgatgaga atgtgcacaa acccatcagt ttaggttgtt cacacactgt ttgcaagacc      120

tgcttgaata aacttcatcg aaaagcttgt ccttttgacc agactgccat caacacagat      180

attgatgtac ttcctgtcaa cttcgcactt ctccagttag ttggagccca ggtaccagat      240

catcagtcaa ttaagttaag taatctaggt gagaataaac actatgaggt tgcaaagaaa      300

tgcgttgagg atttggcact ctacttaaaa ccactaagtg gaggtaaagg tgtagctagc      360

ttgaaccaga gtgcactgag ccgtccaatg caaaggaaac tggtgacact tgtaaactgt      420

caactggtgg aggaagaagg tcgtgtaaga gccatgcgag cagctcgttc ccttggagaa      480

agaactgtaa cagaactgat attacagcac cagaaccctc agcagttgtc tgccaatcta      540

tgggccgctg tcagggctcg aggatgccag tttttagggc cagctatgca agaagaggcc      600

ttgaagctgg tgttactggc attagaagat ggttctgccc tctcaaggaa agttctggta      660

ctttttgttg tgcagagact agaaccaaga tttcctcagg catcaaaaac aagtattggt      720

catgttgtgc aactactgta tcgagcttct tgttttaagg ttaccaaaag agatgaagac      780

tcttccctaa tgcagctgaa ggaggaattt cggagttatg aagcattacg cagagaacat      840

gatgcccaaa ttgttcatat tgccatggaa gcaggactcc gtatttcacc tgaacagtgg      900

tcctctcttt tgtatggtga tttggctcat aaatcacaca tgcagtctat cattgataag      960

ctacagtctc cagagtcatt tgcaaagagt gtccaggaat tgacaattgt tttgcaacga     1020

acaggtgacc cagctaactt aaatagactg aggcctcatt tagagcttct tgcaaacata     1080

gaccctaatc cagacgctgt ttcaccaact tgggagcagc tggaaaatgc aatggtagct     1140

gttaaaacag tagttcatgg ccttgtggac ttcatacaaa attatagtag aaaaggccat     1200

gagacccctc agcctcagcc aaacagcaaa tacaagacta gcatgtgccg agatttgcga     1260

cagcaagggg gttgtccacg aggaacaaat tgtacatttg cccattctca ggaagagctt     1320

gaaaagtatc gattaaggaa caaaaagatc aatgccactg taagaacgtt tcctcttcta     1380

aataaagttg gtgtaaacaa cactgtcaca accacagccg gaaatgtcat ttctgtcata     1440

ggaagtactg aaacaacagg gaaaattgtt ccaagtacaa acggaatttc aaatgcagaa     1500

aacagtgttt cccagctaat ctcacgtagt actgacagta ccttaagagc tctggagacc     1560

gtgaagaaag tgggaaaggt tggcgctaat ggtcagaatg ctgctgggcc ctctgcagat     1620

tctgtaactg aaaataaaat tggttctcca cccaagactc ctgtaagtaa tgtagcagct     1680

acctcagctg ggccctctaa tgttggaaca gagctgaatt ctgtgcctca aaaatccagc     1740

ccatttctaa ctagagtacc agtatatcct ccgcattctg aaaacattca gtattttcaa     1800

gatccaagga ctcagatacc ctttgaagtc ccacagtacc cacagacagg atactatcca     1860

ccacctccaa cggtaccagc tggtgtggct ccctgtgttc ctcgctttgt gaggtccaat     1920

aacgttccag agtcctccct cccacctgct tccatgccat atgccgatca ttacagtaca     1980

ttttcccctc gagatcgaat gaattcttct ccttaccagc ctcctcctcc gcagccgtat     2040

ggaccagttc ctccagtacc ttctggaatg tatgctcctg tgtacgacag caggcgcatc     2100

tggcgcccac ctatgtacca acgagatgac attattagaa gcaattcttt acctccaatg     2160

gatgtgatgc actcatctgt ctatcagaca tctttgcggg aaagatataa ctcattagat     2220

ggatattatt cggtggcttg tcagccacca agtgagccaa ggacaactgt gcctttacca     2280

agggaacctt gtggtcattt gaagaccagt tgcgaggagc agataagaag aaagccagat     2340

cagtgggcac agtaccacac tcagaaagca cctcttgtct cttcaactct tcctgtggca     2400

acacagtcac caacaccacc ttctcctctg ttcagtgtag actttcgtgc ggatttctca     2460

gagagtgtga gtggtacaaa atttgaagaa gatcatcttt cccattattc tccctggtct     2520

tgtggcacca taggctcctg tataaatgcc attgattcag agcccaaaga tgtcattgct     2580

aattcaaatg ctgtgttaat ggacctggac agtggtgatg ttaagagaag agtacattta     2640

tttgaaaccc agagaaggac aaaagaagaa gatccaataa ttccctttag tgatggaccc     2700

atcatctcaa aatggggtgc gatttccaga tcttcccgta caggttacca taccacagat     2760

cctgtccagg ccactgcttc ccaaggaagt gcgactaagc ccatcagtgt atcagattat     2820

gtcccttatg tcaatgctgt tgattcaagg tggagttcat atggcaacga ggccacatca     2880

tcagcacact atgttgaaag ggacagattc attgttactg atttatctgg tcatagaaag     2940

cattccagta ctggggacct tttgagcctt gaacttcagc aggccaagag caactcatta     3000

cttcttcaga gagaggccaa tgctttggcc atgcaacaga agtggaattc cctggatgaa     3060

ggccgtcacc ttaccttaaa ccttttaagc aaggaaattg aactaagaaa tggagaggta     3120

aagaaactga acctttcggc ttcatgctta atgtatttgt tttctgctgc tgcatcttgg     3180

ttataccatt actga                                                      3195


<210>  482
<211>  4701
<212>  DNA
<213>  Homo sapiens;

<400>  482
atgacagcgg acaaagacaa agacaaagac aaagagaagg accgggaccg agaccgggac       60

cgagagagag agaaaagaga caaagcaaga gagagtgaga attcaaggcc acgccggagc      120

tgtaccttgg aaggaggagc caaaaattat gctgagagtg atcacagtga agacgaggac      180

aatgacaaca atagtgccac cgcagaggag tccacgaaga agaataagaa gaaaccaccg      240

aaaaaaaagt ctcgttatga aaggacagat accggtgaga taacatccta catcactgaa      300

gatgatgtgg tctacagacc aggagactgt gtgtatatcg agagtcggag gccaaacaca      360

ccgtatttca tctgtagcat tcaagacttc aaactggtcc acaactccca ggcctgttgc      420

agatctccaa ctcctgcttt gtgtgacccc ccagcatgct ctctgccggt ggcatcacag      480

ccaccacagc atctttctga agccgggaga gggcctgtag ggagtaagag ggaccatctc      540

ctcatgaacg tcaaatggta ctaccgtcaa tctgaggttc cagattctgt gtatcagcat      600

ttggttcagg atcgacataa tgaaaatgac tctggaagag aacttgtcat tacagaccca      660

gttatcaaga accgagagct cttcatttct gattacgttg acacttacca tgctgctgcc      720

cttagaggga agtgtaacat ctcccatttt tctgacatat ttgctgctag agagtttaaa      780

gcccgagtgg attcattttt ctacatatta ggatataacc ctgagacaag gaggctgaac      840

agtacccagg gggagattcg tgtcggtcct agtcatcagg ccaaacttcc agatctgcaa      900

ccatttcctt ctccagatgg tgatacagtg acccaacatg aggaactggt ctggatgcct      960

ggagttaacg actgtgacct ccttatgtac ttgagggcag caaggagcat ggcggcattt     1020

gcaggaatgt gtgatggagg ctctacagag gacggctgtg tcgcagcctc tcgggatgac     1080

accactctga atgcactgaa cacactgcat gaaagcggtt acgatgctgg caaagccctg     1140

cagcgcctgg tgaagaagcc tgtgcccaag ctcatcgaga agtgctggac cgaggacgaa     1200

gtgaaacgct tcgttaaggg actcaggcag tacgggaaga acttcttcag aattagaaag     1260

gagctgcttc ccaataagga aacaggggag ctgatcacct tctattacta ttggaagaag     1320

acccccgaag cagccagctc ccgagcccat cgtaggcacc gcaggcaggc cgtgttcagg     1380

aggattaaga ctcgcaccgc gtccacaccc gtcaacacac cctccagacc cccgtccagt     1440

gaattcttgg acctaagttc agccagtgaa gatgacttcg acagtgagga cagtgagcag     1500

gagctgaagg ggtacgcctg ccgccactgc ttcaccacca cctccaaaga ttggcaccac     1560

ggaggccggg agaacatcct gctttgcacc gactgtcgca tccacttcaa gaaatacggt     1620

gagctcccgc ccattgagaa gcccgtggac ccgccaccgt ttatgttcaa acccgtcaag     1680

gaagaggatg atgggctcag tgggaagcat agcatgagga cacggcggag tcggggctcg     1740

atgtcgacac tacgcagtgg tcggaagaag cagccagcca gccctgatgg tcgcacctca     1800

cccatcaatg aagacatccg ctccagcggc cggaactccc ccagcgctgc cagtacctcc     1860

agcaatgaca gtaaagcaga gacagtgaag aagtcggcca agaaggtgaa ggaggaagcc     1920

tcttcccctc ttaagagtaa caaacgccag cgggagaagg tggcctctga tacggaggag     1980

gctgacagga ccagctccaa gaagacaaaa acgcaggaga tcagcaggcc caactcgcca     2040

tctgaaggtg agggagagag ttcagacagt cgcagcgtca acgatgaggg tagcagtgac     2100

cccaaagaca tcgaccagga caatcgcagc acgtccccga gcatccccag cccccaggac     2160

aatgagagtg actcggactc gtcagcccag cagcagatgc tgcaggccca gcccccagcc     2220

ttgcaggctc ccactggggt caccccagct ccctcctcag ctcctccagg gacccctcag     2280

ctgcccacgc cagggcccac gccctctgcc actgcagttc ccccacaggg ctcccccacg     2340

gcctcccagg cccctaacca gccacaggct cccacagcgc ctgttcccca cacccacatc     2400

caacaggcac cggccttgca cccccagcgg ccgccctcac cgcatccccc gccgcatccc     2460

tcgccacatc ccccgctgca gcctctgact gggtcggcgg gccagccttc tgcaccctct     2520

catgcccagc ccccactgca cggtcagggc ccacccggcc ctcacagcct gcaggctggg     2580

cccctgctgc agcacccagg ccccccacag ccctttggcc tccctcccca ggcctcccaa     2640

ggccaggccc ctctggggac ctccccagca gcagcgtacc ctcacacctc cctgcagctg     2700

ccagcctctc agtcagcgct gcagtcccaa cagcctccac gggagcagcc cctgccacca     2760

gcgcccttgg ccatgcccca catcaagccc ccgcctacca ctcccatccc ccagctgccg     2820

gcgccacagg cccacaagca ccctccccac ctctcggggc cctcaccctt ctccatgaat     2880

gccaacctgc ctccccctcc agccctgaag cccctgagct ccctgtccac acatcacccc     2940

ccgtcggctc accccccacc cctgcaactc atgcctcaga gccagccatt gccctcctcg     3000

cccgcccagc cccccgggct gacccagagc cagaacctgc ccccgccccc tgcctcccac     3060

ccccctacag gcctccacca ggtggccccc caacccccgt ttgctcagca cccctttgtc     3120

cctggaggcc ctcctcccat cacccctccg acctgcccct ccacctctac cccaccggcg     3180

ggacctggca cctcggccca gccaccctgc tctggtgcgg cggcttcagg aggcagcata     3240

gcgggggggt cgtcctgccc actccccacc gtccagatca aggaggaggc tctggacgac     3300

gctgaggagc ctgagagccc ccctccccca ccaaggagcc cgtccccgga gcccactgtg     3360

gtggacaccc ccagtcacgc cagccagtca gctaggttct acaaacacct ggaccggggc     3420

tacaactcgt gtgcccggac agacctgtac ttcatgcctc tggccgggtc caagctggcc     3480

aagaagaggg aggaggccat tgagaaggcc aagcgcgagg ctgagcagaa agcccgagag     3540

gagcgagagc gggagaagga gaaggagaag gagcgggagc gggagcgaga gcgggagcgc     3600

gaggcagagc gggcggctaa ggcgtccagc tcagcgcatg aaggtcgcct cagtgaccca     3660

cagctcagtg gtcctggcca catgcggcca tccttcgagc caccaccaac caccattgct     3720

gctgtgcccc cctacatcgg gcccgacaca cctgcccttc ggactctgag cgagtacgcc     3780

cggccccacg tcatgtcgcc caccaaccgc aaccacccct tctacatgcc ccttaacccc     3840

acggaccccc tgctggccta ccacatgcct ggcctctaca acgtcgaccc caccatccgc     3900

gagcgggagc tccgggagcg ggagatccga gagcgggaga tccgagagcg ggagctgcgg     3960

gagaggatga agccgggctt cgaggtgaag cccccagagc tggaccccct gcacccagcc     4020

gccaacccca tggagcactt tgcccggcac agcgccctca ccatcccccc gaccgccggg     4080

ccccaccctt ttgcttcttt ccacccgggc ctgaacccct tggagaggga gagactggcc     4140

ctggcgggcc cccagctgcg gcccgagatg agctaccctg acagactggc agccgagcgt     4200

atccacgcag agcgcatggc atcgctgacc agcgatcccc tggcccgact gcagatgttc     4260

aacgtgactc cgcaccatca ccagcactct cacattcact cccacctcca cctccaccag     4320

caggaccccc tccaccaagg ttcagcaggc cccgttcacc cgctggtcga ccccctgact     4380

gccggtcccc acctggctcg cttcccctac ccgcctggca ctctccccaa ccctctgctt     4440

ggacagcccc cacacgagca cgagatgctt cgccacccag ttttcggcac cccctacccc     4500

cgtgacctgc ctggggccat cccacccccc atgtcagcag cccaccagct gcaggccatg     4560

catgcccagt cggccgagct gcagagactg gccatggagc agcagtggct gcatggacac     4620

ccccacatgc atggtggcca cctaccaagt caggaagatt attacagtcg actgaagaaa     4680

gaaggtgaca agcagttata a                                               4701


<210>  483
<211>  1701
<212>  DNA
<213>  Homo sapiens;

<400>  483
atgccaggga agcccaagca cctgggcgtc cccaacgggc gcatggttct ggctgtgtca       60

gatggagagc tgagcagcac gacggggccc cagggccagg gcgagggccg cggcagctct      120

ctcagcatcc acagcctccc cagtggtccc agcagcccct tcccaaccga ggagcagcct      180

gtggccagct gggccctgtc cttcgagcgg ctgttgcagg acccgctggg cctggcttac      240

ttcactgagt tcctgaagaa ggagttcagc gcggaaaacg tgactttctg gaaggcctgc      300

gagcgcttcc agcagatccc ggccagcgat acccagcagc tagctcagga ggcccgcaac      360

atctaccagg agttcctgtc cagccaggcg ctgagcccag tgaacatcga ccgtcaggcc      420

tggcttggcg aggaggtgct ggccgagccc cggccggaca tgtttcgggc acagcagctt      480

cagatcttca acttgatgaa gttcgacagc tatgcgcgct tcgtcaagtc cccgctgtac      540

cgcgagtgcc tgctagccga agccgaggga cgccctctgc gggaacctgg ctcctcgcgc      600

ctcggcagcc ctgacgccac gaggaagaag ccgaagctga agcccgggaa gtcgctgccg      660

ctgggtgtgg aggagttggg gcagctgcca cccgttgagg gtcctggggg ccgccctctc      720

cgcaagtcct tccgccggga gctgggcggg actgcaaacg ccgccttgcg ccgagagtct      780

cagggctccc tcaactcctc cgccagcctg gaccttggct tcctagcctt cgtcagcagc      840

aaatctgaga gccaccggaa gagccttggg agcacggagg gtgaaagtga aagccggcca      900

gggaagtact gctgtgtgta cctgcccgat ggcacagcct ccttggccct ggccagacct      960

ggcctcacca tccgagacat gctggcaggg atctgtgaga aacgaggcct ctctctacct     1020

gacatcaagg tctacctggt gggcaatgaa caggccctgg tcctggatca ggactgcacc     1080

gtgctggcgg atcaggaagt gcggctggaa aacaggatca ccttcgagct ggagctgacg     1140

gcgctggagc gcgtggtacg aatctcagcc aagcccacca agcggctgca ggaggcgctg     1200

cagcccattc tggagaagca cggcttgagc ccgctagagg tggtgctgca ccggccaggc     1260

gagaaacagc ctctggatct ggggaagcta gtgagctcgg tggcggccca gagactggtt     1320

ttggacactc ttccaggtgt gaagatctcc aaagcccgtg acaaatctcc ctgccgcagc     1380

cagggctgcc cacctagaac tcaggataag gccacccatc cccctccagc gtcccccagt     1440

tctctggtga aggtgcccag tagtgccact ggaaagcggc agacctgtga catcgaaggc     1500

ctggtggagc tgctgaaccg ggtgcagagc agcggggccc acgaccagag gggccttctg     1560

aggaaagagg acctggtact tccagaattt ctgcagctgc ccgcccaagg gcccagctcc     1620

gaggagaccc caccacagac caaatcagca gcccagccca tcgggggatc cttgaactcc     1680

accaccgact cagccctctg a                                               1701


<210>  484
<211>  654
<212>  DNA
<213>  Homo sapiens;

<400>  484
atgcccaccc cgcatgaggc tgagaagcag atcacagggc cagaggaggc ggaccggccc       60

ccttcaatgt ccagtcatga tacagcctct ccagcggccc ccagccgcaa cccctgctgc      120

ctgtgctggt gctgctgctg tagctgctcc tggaaccaag agcggcggcg cgcgtggcag      180

gcctcccggg agagcaagct gcagcccctc cccagctgtg aagtatgtgc cacgccaagt      240

cctgaggagg tgcagagctg ggcgcagtct tttgacaagc tgatgcacag cccagcggga      300

cgcagcgtgt tccgggcgtt cctgcggaca gagtacagcg aggagaacat gctcttctgg      360

ttggcctgcg aggagctgaa ggccgaggcc aaccagcatg tggtagacga gaaggcgagg      420

ctcatctacg aggactacgt atccatcctg tcccccaagg aggtgagcct ggactcccgt      480

gtgcgggagg gcatcaacaa gaagatgcag gagccgtccg cacacacgtt cgacgacgcg      540

cagctgcaga tctacacgct catgcaccgg gactcctacc cccgcttcct cagctctccc      600

acctaccgtg ccctgctgct gcaggggcca tcacagtcct cctccgaggc ctag            654


<210>  485
<211>  576
<212>  DNA
<213>  Homo sapiens;

<400>  485
atgcagagca tcaagtgcgt ggtggtgggt gatggggctg tgggcaagac gtgcctgctc       60

atctgctaca caactaacgc tttccccaaa gagtacatcc ccaccgtgtt cgacaattac      120

agcgcgcaga gcgcagttga cgggcgcaca gtgaacctga acctgtggga cactgcgggc      180

caggaggagt atgaccgcct ccgtacactc tcctaccctc agaccaacgt tttcgtcatc      240

tgtttctcca ttgccagtcc gccgtcctat gagaacgtgc ggcacaagtg gcatccagag      300

gtgtgccacc actgccctga tgtgcccatc ctgctggtgg gcaccaagaa ggacctgaga      360

gcccagcctg acaccctacg gcgcctcaag gagcagggcc aggcgcccat cacaccgcag      420

cagggccagg cactggccaa gcagatccac gctgtgcgct acctcgaatg ctcagccctg      480

caacaggatg gtgtcaagga agtgttcgcc gaggctgtcc gggctgtgct caaccccacg      540

ccgatcaagc gtgggcggtc ctgcatcctc ttgtga                                576


<210>  486
<211>  2958
<212>  DNA
<213>  Homo sapiens;

<400>  486
atgatccgac acgccggggc gcccgcgcgc ggggacccca cgggtccggt tccagttgtt       60

ggcaaaggag aggaagagga agaggaagat ggcatgcggc tttgtctgcc agccaacccg      120

aaaaactgcc ttcctcaccg ccggggcatc agcatcctgg agaagctcat caaaacatgc      180

ccggtgtggc tgcagctgag tctgggccag gcagaggtgg ccaggatcct gcaccgggtg      240

gtggctggga tgttcctggt tcgccgggac agcagctcga agcagctggt gctctgtgtc      300

cactttcctt ctctgaacga aagctcggcc gaggtgctcg aatacaccat taaggaagaa      360

aagtcgatat tgtacctgga aggctcggct cttgtgtttg aggacatctt cagattgatt      420

gcgttctact gtgtcagtag agacttactg cccttcacac tgcggctacc ccaggccatc      480

cttgaggcca gcagcttcac ggaccttgag accatcgcca acctgggtct gggtttctgg      540

gactcctcgc tgaatcctcc acaagaaaga gggaagccag cagagccccc aagagaccgg      600

gcccccggat tccccctagt ctccagcctc aggcccacag cccatgacgc aaactgtgcc      660

tgtgaaatcg agctgtcggt aggaaatgac cgcctgtggt ttgtgaatcc tattttcatc      720

gaggactgca gcagcgccct gcccaccgac cagccacctc ttggaaattg ccctgcacgc      780

cctttgccgc ccacctctga tgccacctca cccacctcca ggtgggcccc acgccgccca      840

ccaccccctc ccccagtgct gcccctgcag ccctgcagcc cagcccagcc ccctgtgctc      900

cctgctcttg cccccgcccc tgcctgtcct ttgcccacct ctcccccagt gcctgccccc      960

cacgtcacac cccatgcccc aggtccccca gaccatccga accagccgcc catgatgacc     1020

tgcgagagac tcccatgccc cactgcaggc ctgggccccc tcagggagga agcgatgaag     1080

ccaggggcag cctccagtcc cttgcagcag gtccccgccc cgccactgcc tgcgaagaag     1140

aaccttccca ctgcccctcc cagacgccgc gtttccgaga gggtgtcctt agaagaccaa     1200

agtccgggga tggcggcaga gggggaccag ctcagcctgc ctccccaagg gacctcagac     1260

ggccctgagg acacgccccg ggagagcacg gagcaaggcc aggacacaga ggtgaaagcc     1320

agcgatcctc acagcatgcc agagctgccc aggacagcca aacaaccccc agtcccgccc     1380

cccaggaaaa aacggatctc tcgacaactg gcctcgaccc tcccagctcc cttagagaac     1440

gctgagctct gcacacaggc gatggccttg gagacaccca cgccgggtcc acccagagag     1500

ggccaaagcc ctgcttctca ggctgggact cagcaccctc ctgcccaggc cactgcccat     1560

tcccagagct ctccagagtt caagggctcc ctggcctccc tctcagacag cttgggggtg     1620

tctgtcatgg ccaccgacca ggactcctac tccaccagca gcacggagga ggagctggag     1680

cagttcagca gccccagcgt gaagaagaag ccctccatga tcctgggcaa ggctcggcac     1740

cggctgagct ttgccagttt cagcagcatg ttccacgctt tcctctccaa caaccgcaag     1800

ctgtacaaga aggtggtgga gctggcgcag gacaagggct cgtactttgg cagcctggtg     1860

caggactaca aggtgtacag cctggagatg atggcgcgcc agacctccag cacggagatg     1920

ctgcaggaga ttcgcaccat gatgacccag ctcaagagct acctgctgca gagcaccgag     1980

ctcaaggccc tggtggaccc cgccctgcac tccgaggagg agctcgaagc aattgtagag     2040

tctgccttgt acaaatgtgt cctgaagccc ctgaaggaag ccatcaactc atgcctgcat     2100

cagatccaca gcaaggatgg ttcgctgcag cagctcaagg agaaccagtt agtgatcctg     2160

gccaccacca ccactgacct aggtgtgacc accagcgtgc cggaggtgcc catgatggag     2220

aagatcctgc agaagttcac cagcatgcac aaggcctact cacctgagaa gaagatctcc     2280

atcctgctca agacctgcaa actcatctac gactccatgg ccctcggcaa cccagggaag     2340

ccctatgggg cggatgactt cctgcctgtg ctcatgtatg tgctggcccg cagcaacctc     2400

acggagatgc ttctcaatgt ggagtacatg atggagctca tggaccccgc cctgcagctg     2460

ggggagggtt cctactatct gaccaccacc tacggggccc tggagcacat caagagctac     2520

gacaagatca cggtgacccg gcagctgagt gtggaggtgc aggactccat ccaccgctgg     2580

gagcgccggc gtactctcaa caaggcccgg gcctcccgct cctccgtaca ggacttcatc     2640

tgcgtgtcgt acctggagcc cgagcagcag gcgcggacgc tggcgtcgcg ggcggacacc     2700

caggcccagg cgctgtgcgc gcagtgcgcg gagaagttcg cggtggagcg gccgcaggcg     2760

caccggctgt tcgtgctggt ggacgggcgc tgcttccagc tggcggacga cgcgctgccg     2820

cactgcatca agggctacct gctgcgcagc gagcccaagc gcgacttcca ctttgtctac     2880

cggcccctgg acggtggtgg cggcggcggc ggcgggagcc cgccctgcct ggtggtgcgg     2940

gagcccaact tcctgtga                                                   2958


<210>  487
<211>  771
<212>  DNA
<213>  Homo sapiens;

<400>  487
atgcgccctg cagccctgcg cggggccctg ctgggctgcc tctgcctggc gttgctttgc       60

ctgggcggtg cggacaagcg cctgcgtgac aaccatgagt ggaaaaaact aattatggtt      120

cagcactggc ctgagacagt atgcgagaaa attcaaaacg actgtagaga ccctccggat      180

tactggacaa tacatggact atggcccgat aaaagtgaag gatgtaatag atcgtggccc      240

ttcaatttag aagagattaa ggatcttttg ccagaaatga gggcatactg gcctgacgta      300

attcactcgt ttcccaatcg cagccgcttc tggaagcatg agtgggaaaa gcatgggacc      360

tgcgccgccc aggtggatgc gctcaactcc cagaagaagt actttggcag aagcctggaa      420

ctctacaggg agctggacct caacagtgtg cttctaaaat tggggataaa accatccatc      480

aattactacc aagttgcaga ttttaaagat gcccttgcca gagtatatgg agtgataccc      540

aaaatccagt gccttccacc aagccaggat gaggaagtac agacaattgg tcagatagaa      600

ctgtgcctca ctaagcaaga ccagcagctg caaaactgca ccgagccggg ggagcagccg      660

tcccccaagc aggaagtctg gctggcaaat ggggccgccg agagccgggg tctgagagtc      720

tgtgaagatg gcccagtctt ctatccccca cctaaaaaga ccaagcattg a               771


<210>  488
<211>  1260
<212>  DNA
<213>  Homo sapiens;

<400>  488
atgagctgcg cggggcgggc gggccctgcc cggctcgccg cgctcgccct gctgacctgc       60

agcctgtggc cggcacgggc agacaacgcg agccaggagt actacacggc gctcatcaac      120

gtgacggtgc aggagcccgg ccgcggcgcc ccgctcacgt ttcgcatcga ccgcgggcgc      180

tacgggcttg actcccccaa ggccgaggtc cgcggccagg tgctggcgcc gctgcccctc      240

cacggagttg ctgatcatct gggctgtgat ccacaaaccc ggttctttgt ccctcctaat      300

atcaaacagt ggattgcctt gctgcagagg ggaaactgca cgtttaaaga gaaaatatca      360

cgggccgctt tccacaatgc agttgctgta gtcatctaca ataataaatc caaagaggag      420

ccagttacca tgactcatcc aggcactgga gatattattg ctgtcatgat aacagaattg      480

aggggtaagg atattttgag ttatctggag aaaaacatct ctgtacaaat gacaatagct      540

gttggaactc gaatgccacc gaagaacttc agccgtggct ctctagtctt cgtgtcaata      600

tcctttattg ttttgatgat tatttcttca gcatggctca tattctactt cattcagaag      660

atcaggtaca caaatgcacg cgacaggaac cagcgtcgtc tcggagatgc agccaagaaa      720

gccatcagta aattgacaac caggacagta aagaagggtg acaaggaaac tgacccagac      780

tttgatcatt gtgcagtctg catagagagc tataagcaga atgatgtcgt ccgaattctc      840

ccctgcaagc atgttttcca caaatcctgc gtggatccct ggcttagtga acattgtacc      900

tgtcctatgt gcaaacttaa tatattgaag gccctgggaa ttgtgccgaa tttgccatgt      960

actgataacg tagcattcga tatggaaagg ctcaccagaa cccaagctgt taaccgaaga     1020

tcagccctcg gcgacctcgc cggcgacaac tcccttggcc ttgagccact tcgaacttcg     1080

gggatctcac ctcttcctca ggatggggag ctcactccga gaacaggaga aatcaacatt     1140

gcagtaacaa aagaatggtt tattattgcc agttttggcc tcctcagtgc cctcacactc     1200

tgctacatga tcatcagagc cacagctagc ttgaatgcta atgaggtaga atggttttga     1260


<210>  489
<211>  693
<212>  DNA
<213>  Homo sapiens;

<400>  489
atgggacagc aaatttcgga tcagacacag ttggttatta acaagttacc agaaaaagta       60

gcaaaacatg ttacgttggt tcgagagagt ggctccttaa cttatgaaga atttcttggg      120

agagtagctg agcttaatga tgtaacggct aaagtggctt ctggccagga aaaacatctt      180

ctctttgagg tacaacctgg gtctgattcc tctgcttttt ggaaagtggt tgtacgggtg      240

gtctgtacca agattaacaa aagcagtggc attgtggagg catcacggat catgaattta      300

taccagttta ttcaacttta taaagatatc acaagtcaag cagcaggagt attggcacag      360

agctccacct ctgaagaacc tgatgaaaac tcatcctctg taacatcttg tcaggctagt      420

ctttggatgg gaagggtgaa gcagctgacc gatgaggagg agtgttgtat ctgtatggat      480

gggcgggctg acctcatcct gccttgtgct cacagctttt gtcagaagtg tattgataaa      540

tggagtgatc gacacaggaa ttgccctatt tgtcgcctac agatgactgg agcaaatgaa      600

tcttgggtgg tatcagatgc acccactgaa gatgatatgg ctaactatat tcttaacatg      660

gctgatgagg caggccagcc ccacaggcca tga                                   693


<210>  490
<211>  1077
<212>  DNA
<213>  Homo sapiens;

<400>  490
atggctggct gtggtgaaat tgatcattca ataaacatgc ttcctacaaa caggaaagcg       60

aacgagtcct gttctaatac tgcaccttct ttaaccgtcc ctgaatgtgc catttgtctg      120

caaacatgtg ttcatccagt cagtctgccc tgtaagcacg ttttctgcta tctatgtgta      180

aaaggagctt catggcttgg aaagcggtgt gctctttgtc gacaagaaat tcccgaggat      240

ttccttgaca agccaacctt gttgtcacca gaagaactca aggcagcaag tagaggaaat      300

ggtgaatatg catggtatta tgaaggaaga aatgggtggt ggcagtacga tgagcgcact      360

agtagagagc tggaagatgc tttttccaaa ggtaaaaaga acactgaaat gttaattgct      420

ggctttctgt atgtcgctga tcttgaaaac atggttcaat ataggagaaa tgaacatgga      480

cgtcgcagga agattaagcg agatataata gatataccaa agaagggagt agctggactt      540

aggctagact gtgatgctaa taccgtaaac ctagcaagag agagctctgc tgacggagcg      600

gacagtgtat cagcacagag tggagcttct gttcagcccc tagtgtcttc tgtaaggccc      660

ctaacatcag tagatggtca gttaacaagc cctgcaacac catcccctga tgcaagcact      720

tctctggaag actcttttgc tcatttacaa ctcagtggag acaacacagc tgaaaggagt      780

cataggggag aaggagaaga agatcatgaa tcaccatctt caggcagggt accagcacca      840

gacacctcca ttgaagaaac tgaatcagat gccagtagtg atagtgagga tgtatctgca      900

gttgttgcac agcactcctt gacccaacag agacttttgg tttctaatgc aaaccagaca      960

gtacccgatc gatcagatcg atcgggaact gatcgatcag tagcaggggg tggaacagtg     1020

agtgtcagtg tcagatctag aaggcctgat ggacagtgca cagtaactga agtttaa        1077


<210>  491
<211>  2199
<212>  DNA
<213>  Homo sapiens;

<400>  491
atgggctccg agaaggactc cgagtcgccg cgctccacat cgctacatgc ggccgcaccc       60

gaccctaagt gccgcagcgg cggccggcgc cggcgcctca ccttgcacag cgtcttctct      120

gcctcggccc gcggccgccg cgcccgggcc aagccgcagg ccgagccgcc gcccccggct      180

gcgcagccgc cgcccgcccc ggcccctgcc gcggcccagg gcccgccgcc cgaggcgctg      240

cccgccgagc cggccgccga ggccgaggcg gaggccgcgg cggcggcggc ggagcctggg      300

ttcgacgatg aggaggcggc ggagggcggt ggcccgggcg cggaggaggt ggagtgtccg      360

ctgtgcctgg tgcggctgcc gcctgagcgg gccccgcgcc tcctcagctg tccgcaccgc      420

tcgtgccggg actgcctccg ccactacctg cgcctggaga taagcgagag cagggtgccc      480

atcagctgcc ccgagtgcag cgagcgactc aacccgcacg acatccgctt gctgctcgcc      540

gacccgccgc ttatgcacaa gtacgaggag ttcatgctgc gccgctacct agcctcggac      600

cccgactgcc gctggtgccc ggccccggac tgcggttatg ctgttattgc ctatggctgt      660

gccagctgcc cgaagctaac ttgtgagagg gaaggttgcc agactgagtt ctgctaccac      720

tgcaagcaga tatggcatcc aaatcagaca tgcgatatgg cccgtcaaca gagggcccag      780

actttacgag ttcggaccaa acacacttca ggtctcagtt atgggcaaga atctggacca      840

gcagatgaca tcaagccatg cccacgatgc agtgcataca ttatcaagat gaatgatgga      900

agctgtaatc acatgacctg tgcagtgtgt ggctgtgaat tctgttggct ttgtatgaaa      960

gagatctcag acttgcatta cctcagcccc tctggctgta cattctgggg caagaagcca     1020

tggagccgta agaagaaaat tctttggcag ctgggcacgt tgattggtgc tccagtgggg     1080

atttctctca ttgctggcat tgccattcct gccatggtca ttggcattcc tgtttatgtt     1140

ggaaggaaga ttcacagcag gtatgaggga aggaaaacct ccaaacacaa gaggaatttg     1200

gctatcactg gaggagtgac tttgtcggtc attgcatccc cagttattgc tgcagttagt     1260

gttggtattg gtgtccccat tatgctggca tatgtttatg gggttgtgcc catttctctt     1320

tgtcgtggag gcggctgtgg agttagcaca gccaacggaa aaggagtgaa aattgaattt     1380

gatgaagatg atggtccaat cacagtggca gatgcctgga gagccctcaa gaatcccagc     1440

attggggaaa gcagcattga aggcctgact agtgtattga gcactagtgg aagccctaca     1500

gatggactta gtgttatgca aggtccttac agcgaaacgg ccagctttgc agccctctca     1560

gggggcacgc tgagtggcgg cattctctcc agtggcaagg gaaaatatag caggttagaa     1620

gttcaagccg atgtccaaaa ggaaattttc cccaaagaca cagccagtct tggtgcaatt     1680

agtgacaacg caagcactcg tgctatggcc ggttccataa tcagttccta caacccacag     1740

gacagagaat gcaacaatat ggaaatccaa gtggacattg aagccaaacc aagccactat     1800

cagctggtga gtggaagcag cacggaggac tcgctccatg ttcatgctca gatggcagag     1860

aatgaagaag aaggtagtgg tggcggaggc agtgaagagg atcccccctg cagacaccaa     1920

agctgtgaac agaaagactg cctggccagc aaaccttggg acatcagcct ggcccagcct     1980

gaaagcatcc gcagtgacct agagagttct gatgcacagt cagacgatgt gccagacatc     2040

acctcagatg agtgtggctc cccccgctcc catactgcag cctgcccctc gacccccaga     2100

gcccaaggtg caccgagccc aagtgcccat atgaacctct ctgccctagc cgagggacaa     2160

actgtcttga agccagaagg tggagaagcc agagtatga                            2199


<210>  492
<211>  654
<212>  DNA
<213>  Homo sapiens;

<400>  492
atgagcagca aagtctctcg cgacaccctg tacgaggcgg tgcgggaagt cctgcacggg       60

aaccagcgca agcgccgcaa gttcctggag acggtggagt tgcagatcag cttgaagaac      120

tatgatcccc agaaggacaa gcgcttctcg ggcaccgtca ggcttaagtc cactccccgc      180

cctaagttct ctgtgtgtgt cctgggggac cagcagcact gtgacgaggc taaggccgtg      240

gatatccccc acatggacat cgaggcgctg aaaaaactca acaagaataa aaaactggtc      300

aagaagctgg ccaagaagta tgatgcgttt ttggcctcag agtctctgat caagcagatt      360

ccacgaatcc tcggcccagg tttaaataag gcaggaaagt tcccttccct gctcacacac      420

aacgaaaaca tggtggccaa agtggatgag gtgaagtcca caatcaagtt ccaaatgaag      480

aaggtgttat gtctggctgt agctgttggt cacgtgaaga tgacagacga tgagcttgtg      540

tataacattc acctggctgt caacttcttg gtgtcattgc tcaagaaaaa ctggcagaat      600

gtccgggcct tatatatcaa gagcaccatg ggcaagcccc agcgcctata ttaa            654


<210>  493
<211>  387
<212>  DNA
<213>  Homo sapiens;

<400>  493
atggctcctg tgaaaaagct tgtggtgaag gggggcaaaa aaaagaagca agttctgaag       60

ttcactcttg attgcaccca ccctgtagaa gatggaatca tggatgctgc caattttgag      120

cagtttttgc aagaaaggat caaagtgaac ggaaaagctg ggaaccttgg tggaggggtg      180

gtgaccatcg aaaggagcaa gagcaagatc accgtgacat ccgaggtgcc tttctccaaa      240

aggtatttga aatatctcac caaaaaatat ttgaagaaga ataatctacg tgactggttg      300

cgcgtagttg ctaacagcaa agagagttac gaattacgtt acttccagat taaccaggac      360

gaagaagagg aggaagacga ggattaa                                          387


<210>  494
<211>  2208
<212>  DNA
<213>  Homo sapiens;

<400>  494
atgccgctcg cccagctcaa ggagccctgg ccgctcatgg agctagtgcc tctggacccg       60

gagaatggac agacctcagg ggaagaagct ggacttcagc cgtccaagga tgagggcgtc      120

ctcaaggaga tctccatcac gcaccacgtc aaggctggct ctgagaaggc tgatccatcc      180

catttcgagc tcctcaaggt tctgggccag ggatcctttg gcaaagtctt cctggtgcgg      240

aaagtcaccc ggcctgacag tgggcacctg tatgctatga aggtgctgaa gaaggcaacg      300

ctgaaagtac gtgaccgcgt ccggaccaag atggagagag acatcctggc tgatgtaaat      360

cacccattcg tggtgaagct gcactatgcc ttccagaccg agggcaagct ctatctcatt      420

ctggacttcc tgcgtggtgg ggacctcttc acccggctct caaaagaggt gatgttcacg      480

gaggaggatg tgaagtttta cctggctgag ctggctctgg gcctggatca cctgcacagc      540

ctgggtatca tttacagaga cctcaagcct gagaacatcc ttctggatga ggagggccac      600

atcaaactca ctgactttgg cctgagcaaa gaggccattg accacgagaa gaaggcctat      660

tctttctgcg ggacagtgga gtacatggcc cctgaggtcg tcaaccgcca gggccactcc      720

catagtgcgg actggtggtc ctatggggtg ttgatgtttg agatgctgac gggctccctg      780

cccttccagg ggaaggaccg gaaggagacc atgacactga ttctgaaggc gaagctaggc      840

atgccccagt ttctgagcac tgaagcccag agcctcttgc gggccctgtt caagcggaat      900

cctgccaacc ggctcggctc cggccctgat ggggcagagg aaatcaagcg gcatgtcttc      960

tactccacca ttgactggaa taagctatac cgtcgtgaga tcaagccacc cttcaagcca     1020

gcagtggctc agcctgatga caccttctac tttgacaccg agttcacgtc ccgcacaccc     1080

aaggattccc caggcatccc ccccagcgct ggggcccatc agctgttccg gggcttcagc     1140

ttcgtggcca ccggcctgat ggaagacgac ggcaagcctc gtgccccgca ggcacccctg     1200

cactcggtgg tacagcaact ccatgggaag aacctggttt ttagtgacgg ctacgtggta     1260

aaggagacaa ttggtgtggg ctcctactct gagtgcaagc gctgtgtcca caaggccacc     1320

aacatggagt atgctgtcaa ggtcattgat aagagcaagc gggatccttc agaagagatt     1380

gagattcttc tgcggtatgg ccagcacccc aacatcatca ctctgaaaga tgtgtatgat     1440

gatggcaaac acgtgtacct ggtgacagag ctgatgcggg gtggggagct gctggacaag     1500

atcctgcggc agaagttctt ctcagagcgg gaggccagct ttgtcctgca caccattggc     1560

aaaactgtgg agtatctgca ctcacagggg gttgtgcaca gggacctgaa gcccagcaac     1620

atcctgtatg tggacgagtc cgggaatccc gagtgcctgc gcatctgtga ctttggtttt     1680

gccaaacagc tgcgggctga gaatgggctc ctcatgacac cttgctacac agccaacttt     1740

gtggcgcctg aggtgctgaa gcgccagggc tacgatgaag gctgcgacat ctggagcctg     1800

ggcattctgc tgtacaccat gctggcagga tatactccat ttgccaacgg tcccagtgac     1860

acaccagagg aaatcctaac ccggatcggc agtgggaagt ttaccctcag tgggggaaat     1920

tggaacacag tttcagagac agccaaggac ctggtgtcca agatgctaca cgtggatccc     1980

caccagcgcc tcacagctaa gcaggttctg cagcatccat gggtcaccca gaaagacaag     2040

cttccccaaa gccagctgtc ccaccaggac ctacagcttg tgaagggagc catggctgcc     2100

acgtactccg cactcaacag ctccaagccc accccccagc tgaagcccat cgagtcatcc     2160

atcctggccc agcggcgagt gaggaagttg ccatccacca ccctgtga                  2208


<210>  495
<211>  2223
<212>  DNA
<213>  Homo sapiens;

<400>  495
atgccgctgg cgcagctggc ggacccgtgg cagaagatgg ctgtggagag cccgtccgac       60

agcgctgaga atggacagca aattatggat gaacctatgg gagaggagga gattaaccca      120

caaactgaag aagtcagtat caaagaaatt gcaatcacac atcatgtaaa ggaaggacat      180

gaaaaggcag atccttccca gtttgaactt ttaaaagtat tagggcaggg atcatttgga      240

aaggttttct tagttaaaaa aatctcaggc tctgatgcta ggcagcttta tgccatgaag      300

gtattgaaga aggccacact gaaagttcga gaccgagttc ggacaaaaat ggaacgtgat      360

atcttggtag aggttaatca tccttttatt gtcaagttgc attatgcttt tcaaactgaa      420

gggaagttgt atcttatttt ggattttctc aggggaggag atttgtttac acgcttatcc      480

aaagaggtga tgttcacaga agaagatgtc aaattctact tggctgaact tgcacttgct      540

ttagaccatc tacatagcct gggaataatt tatagagact taaaaccaga aaatatactt      600

cttgatgaag aaggtcacat caagttaaca gatttcggcc taagtaaaga gtctattgac      660

catgaaaaga aggcatattc tttttgtgga actgtggagt atatggctcc agaagtagtt      720

aatcgtcgag gtcatactca gagtgctgac tggtggtctt ttggtgtgtt aatgtttgaa      780

atgcttactg gtacactccc tttccaagga aaagatcgaa aagaaacaat gactatgatt      840

cttaaagcca aacttggaat gccacagttt ttgagtcctg aagcgcagag tcttttacga      900

atgcttttca agcgaaatcc tgcaaacaga ttaggtgcag gaccagatgg agttgaagaa      960

attaaaagac attcattttt ctcaacgata gactggaata aactgtatag aagagaaatt     1020

catccgccat ttaaacctgc aacgggcagg cctgaagata cattctattt tgatcctgag     1080

tttactgcaa aaactcccaa agattcacct ggcattccac ctagtgctaa tgcacatcag     1140

ctttttcggg ggtttagttt tgttgctatt acctcagatg atgaaagcca agctatgcag     1200

acagttggtg tacattcaat tgttcagcag ttacacagga acagtattca gtttactgat     1260

ggatatgaag taaaagaaga tattggagtt ggctcctact ctgtttgcaa gagatgtata     1320

cataaagcta caaacatgga gtttgcagtg aagattattg ataaaagcaa gagagaccca     1380

acagaagaaa ttgaaattct tcttcgttat ggacagcatc caaacattat cactctaaag     1440

gatgtatatg atgatggaaa gtatgtgtat gtagtaacag aacttatgaa aggaggtgaa     1500

ttgctggata aaattcttag acaaaaattt ttctctgaac gagaggccag tgctgtcctg     1560

ttcactataa ctaaaaccgt tgaatatctt cacgcacaag gggtggttca tagagacttg     1620

aaacctagca acattcttta tgtggatgaa tctggtaatc cggaatctat tcgaatttgt     1680

gattttggct ttgcaaaaca gctgagagcg gaaaatggtc ttctcatgac tccttgttac     1740

actgcaaatt ttgttgcacc agaggtttta aaaagacaag gctatgatgc tgcttgtgat     1800

atatggagtc ttggtgtcct actctataca atgcttaccg gttacactcc atttgcaaat     1860

ggtcctgatg atacaccaga ggaaatattg gcacgaatag gtagcggaaa attctcactc     1920

agtggtggtt actggaattc tgtttcagac acagcaaagg acctggtgtc aaagatgctt     1980

catgtagacc ctcatcagag actgactgct gctcttgtgc tcagacatcc ttggatcgtc     2040

cactgggacc aactgccaca ataccaacta aacagacagg atgcaccaca tctagtaaag     2100

ggtgccatgg cagctacata ttctgctttg aaccgtaatc agtcaccagt tttggaacca     2160

gtaggccgct ctactcttgc tcagcggaga ggtattaaaa aaatcacctc aacagccctg     2220

tga                                                                   2223


<210>  496
<211>  1086
<212>  DNA
<213>  Homo sapiens;

<400>  496
atgtgggtgc ttacacctgc tgcttttgct gggaagctct tgagtgtgtt caggcaacct       60

ctgagctctc tgtggaggag cctggtcccg ctgttctgct ggctgagggc aaccttctgg      120

ctgctagcta ccaagaggag aaagcagcag ctggtcctga gagggccaga tgagaccaaa      180

gaggaggaag aggaccctcc tctgcccacc accccaacca gcgtcaacta tcacttcact      240

cgccagtgca actacaaatg cggcttctgt ttccacacag ccaaaacatc ctttgtgctg      300

ccccttgagg aagcaaagag aggattgctt ttgcttaagg aagctggtat ggagaagatc      360

aacttttcag gtggagagcc atttcttcaa gaccggggag aatacctggg caagttggtg      420

aggttctgca aagtagagtt gcggctgccc agcgtgagca tcgtgagcaa tggaagcctg      480

atccgggaga ggtggttcca gaattatggt gagtatttgg acattctcgc tatctcctgt      540

gacagctttg acgaggaagt caatgtcctt attggccgtg gccaaggaaa gaagaaccat      600

gtggaaaacc ttcaaaagct gaggaggtgg tgtagggatt atagagtcgc tttcaagata      660

aattctgtca ttaatcgttt caacgtggaa gaggacatga cggaacagat caaagcacta      720

aaccctgtcc gctggaaagt gttccagtgc ctcttaattg agggtgagaa ttgtggagaa      780

gatgctctaa gagaagcaga aagatttgtt attggtgatg aagaatttga aagattcttg      840

gagcgccaca aagaagtgtc ctgcttggtg cctgaatcta accagaagat gaaagactcc      900

taccttattc tggatgaata tatgcgcttt ctgaactgta gaaagggacg gaaggaccct      960

tccaagtcca tcctggatgt tggtgtagaa gaagctataa aattcagtgg atttgatgaa     1020

aagatgtttc tgaagcgagg aggaaaatac atatggagta aggctgatct gaagctggat     1080

tggtag                                                                1086


<210>  497
<211>  711
<212>  DNA
<213>  Homo sapiens;

<400>  497
atggcggagc cgtcggcggc cactcagtcc cattccatct cctcgtcgtc cttcggagcc       60

gagccgtccg cgcccggcgg cggcgggagc ccaggagcct gccccgccct ggggacgaag      120

agctgcagct cctcctgtgc ggtgcacgat ctgattttct ggagagatgt gaagaagact      180

gggtttgtct ttggcaccac gctgatcatg ctgctttccc tggcagcttt cagtgtcatc      240

agtgtggttt cttacctcat cctggctctt ctctctgtca ccatcagctt caggatctac      300

aagtccgtca tccaagctgt acagaagtca gaagaaggcc atccattcaa agcctacctg      360

gacgtagaca ttactctgtc ctcagaagct ttccataatt acatgaatgc tgccatggtg      420

cacatcaaca gggccctgaa actcattatt cgtctctttc tggtagaaga tctggttgac      480

tccttgaagc tggctgtctt catgtggctg atgacctatg ttggtgctgt ttttaacgga      540

atcacccttc taattcttgc tgaactgctc attttcagtg tcccgattgt ctatgagaag      600

tacaagaccc agattgatca ctatgttggc atcgcccgag atcagaccaa gtcaattgtt      660

gaaaagatcc aagcaaaact ccctggaatc gccaaaaaaa aggcagaata a               711


<210>  498
<211>  741
<212>  DNA
<213>  Homo sapiens;

<400>  498
atggttgtag atttctggac ttgggagcag acatttcaag aactaatcca agaggcaaaa       60

ccccgggcca catggacgct gaagttggat ggcaaccttc agctagactg cctggctcaa      120

gggtggaagc aataccaaca gagagcattt ggctggttcc ggtgttcctc ctgccagcga      180

agttgggctt ccgcccaagt gcagattctg tgccacacgt actgggagca ctggacatcc      240

cagggtcagg tgcgtatgag gctctttggc caaaggtgcc agaagtgctc ctggtcccaa      300

tatgagatgc ctgagttctc ctcggatagc accatgagga ttctgagcaa cctggtgcag      360

catatactga agaaatacta tggaaatggc acgaggaagt ctccagaaat gccagtaatc      420

ctggaagtgt ccctggaagg atcccatgac acagccaatt gtgaggcatg cactttgggc      480

atctgtggac agggcttaaa aagctgcatg acaaagccgt ccaaatccct actcccccac      540

ctaaagactg ggaattcctc acctggaatt ggtgctgtgt acctcgcaaa ccaagccaag      600

aaccagtcag ctgaggcaaa agaggctaag gggagtgggt atgagaaatt agggcccagt      660

cgagacccag atccactgaa catctgtgtc tttattttgc tgcttgtatt tattgtagtc      720

aaatgcttta catcagaatg a                                                741


<210>  499
<211>  1389
<212>  DNA
<213>  Homo sapiens;

<400>  499
atggacacca aacatttcct gccgctcgat ttctccaccc aggtgaactc ctccctcacc       60

tccccgacgg ggcgaggctc catggctgcc ccctcgctgc acccgtccct ggggcctggc      120

atcggctccc cgggacagct gcattctccc atcagcaccc tgagctcccc catcaacggc      180

atgggcccgc ctttctcggt catcagctcc cccatgggcc cccactccat gtcggtgccc      240

accacaccca ccctgggctt cagcactggc agcccccagc tcagctcacc tatgaacccc      300

gtcagcagca gcgaggacat caagcccccc ctgggcctca atggcgtcct caaggtcccc      360

gcccacccct caggaaacat ggcttccttc accaagcaca tctgcgccat ctgcggggac      420

cgctcctcag gcaagcacta tggagtgtac agctgcgagg ggtgcaaggg cttcttcaag      480

cggacggtgc gcaaggacct gacctacacc tgccgcgaca acaaggactg cctgattgac      540

aagcggcagc ggaaccggtg ccagtactgc cgctaccaga agtgcctggc catgggcatg      600

aagcgggaag ccgtgcagga ggagcggcag cgtggcaagg accggaacga gaatgaggtg      660

gagtcgacca gcagcgccaa cgaggacatg ccggtggaga ggatcctgga ggctgagctg      720

gccgtggagc ccaagaccga gacctacgtg gaggcaaaca tggggctgaa ccccagctcg      780

ccgaacgacc ctgtcaccaa catttgccaa gcagccgaca aacagctttt caccctggtg      840

gagtgggcca agcggatccc acacttctca gagctgcccc tggacgacca ggtcatcctg      900

ctgcgggcag gctggaatga gctgctcatc gcctccttct cccaccgctc catcgccgtg      960

aaggacggga tcctcctggc caccgggctg cacgtccacc ggaacagcgc ccacagcgca     1020

ggggtgggcg ccatctttga cagggtgctg acggagcttg tgtccaagat gcgggacatg     1080

cagatggaca agacggagct gggctgcctg cgcgccatcg tcctctttaa ccctgactcc     1140

aaggggctct cgaacccggc cgaggtggag gcgctgaggg agaaggtcta tgcgtccttg     1200

gaggcctact gcaagcacaa gtacccagag cagccgggaa ggttcgctaa gctcttgctc     1260

cgcctgccgg ctctgcgctc catcgggctc aaatgcctgg aacatctctt cttcttcaag     1320

ctcatcgggg acacacccat tgacaccttc cttatggaga tgctggaggc gccgcaccaa     1380

atgacttag                                                             1389


<210>  500
<211>  954
<212>  DNA
<213>  Homo sapiens;


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  500
nngcttcctg cgcccgccgc ggcccttccc ggggcgccgc cgccaccgcc tggtgtgcga       60

ggctatccgg cccgggcccg gggcttgcag ggtgccagtg ggggcgcccg gttcccttcc      120

tcgctctctc ttccagtccc cggaaagggt gggtgggtgg tctcccgagc gaagtttcca      180

gcactggatt cctgcgaaat tacgacggct cacccgcgtc tgtgttttgc tgtctctccc      240

ccgttttcct gctccctgcc tcttccctcc cttttccccc actctccact cctcggaagg      300

ccaaaaagac aagcgaaacc tgccgcagac gaagggtttt gggattgtag cgtctgcacc      360

ttcagaaaca gtgctgaagc ctttaaatgc agcatctgcg atgtgaggaa aggcacctcc      420

accagaaaac ctcggatcaa ttctcagctg gtggcacaac aagtggcaca acagtatgcc      480

accccaccac cccctaaaaa ggagaagaag gagaaagttg aaaagcagga caaagagaaa      540

cctgagaaag acaaggaaat tagtcctagt gttaccaaga aaaataccaa caagaaaacc      600

aaaccaaagt ctgacattct gaaagatcct cctagtgaag caaacagcat acagtctgca      660

aatgctacaa caaagaccag cgaaacaaat cacacctcaa ggccccggct gaaaaacgtg      720

gacaggagca ctgcacagca gttggcagta actgtgggca acgtcaccgt cattatcaca      780

gactttaagg aaaagactcg ctcctcatcg acatcctcat ccacagtgac ctccagtgca      840

gggtcagaac agcagaacca gagcagctcg gggtcagaga gcacagacaa gggctcctcc      900

cgttcctcca cgccaaaggg cgacatgtca gcagtcaatg atgaatcttt ctga            954


<210>  501
<211>  2862
<212>  DNA
<213>  Homo sapiens;

<400>  501
atggcggaga ctctgcccgg gtcgggcgac tcgggccctg gcacggcttc tctcggcccg       60

ggcgttgcgg agactgggac gaggcggctc agcgagctgc gggtgatcga tctgcgggcg      120

gagctgaaga agcggaacct ggacacgggc ggcaacaaga gcgtcctgat ggagcggctc      180

aagaaggcgg ttaaagaaga ggggcaagat cctgatgaaa ttggcatcga gttagaagcc      240

accagcaaga agtcagccaa gagatgtgtt aaaggactga agatggagga ggaaggcaca      300

gaagataatg gcctggaaga cgattccaga gacgggcagg aggacatgga agcaagtctg      360

gagaacctgc agaatatggg catgatggac atgagtgtgc tagacgaaac tgaagtggcg      420

aatagcagtg ctccagattt tggggaggat ggcacggacg gccttctcga ttccttttgt      480

gatagtaaag aatacgtggc tgcacagctg agacagctcc cggctcagcc cccagagcat      540

gctgtggatg gggaaggatt taagaacact ttggaaactt catcgttgaa cttcaaagta      600

actccggaca ttgaagaatc ccttttggag ccagaaaatg agaaaatact cgacattttg      660

ggggaaactt gtaaatctga gccagtaaaa gaagaaagtt ccgagctgga gcagccattt      720

gcacaggaca caagtagcgt ggggccagac agaaagcttg cggaggaaga ggacctattt      780

gacagcgccc atccggaaga gggtgattta gatttggcca gcgagtcaac agcacacgct      840

cagtcgagca aggcagacag cctgttagcg gtagtgaaaa gggagcccgc ggagcagcca      900

ggcgatggcg agaggacgga ctgtgagcct gtagggctag agccggcagt tgagcagagt      960

agtgcggcct ccgagctcgc ggaggcctct agcgaggagc tcgcagaagc acccacggaa     1020

gccccaagcc cagaagccag agatagcaaa gaagacggga ggaagtttga ttttgacgct     1080

tgtaatgaag tccctccggc tcctaaagag tcctcaacca gtgagggcgc tgatcagaaa     1140

atgagctctt ttaaggaaga aaaagatata aagccaatca ttaaagatga aaaaggtcgg     1200

gtcggcagcg gttctggtcg gaacctgtgg gtcagcgggc tgtcctccac aacacgcgct     1260

acggatctca agaacctttt cagcaagtat gggaaggttg tcggggccaa agtggtaacg     1320

aacgcccgca gcccgggggc tcgatgctat ggattcgtca ccatgtcgac atctgacgag     1380

gcgaccaagt gcatcagcca tctccacaga actgagctgc atggacgaat gatctccgta     1440

gagaaggcca aaaatgagcc tgctgggaaa aagctttccg acagaaaaga gtgcgaagtg     1500

aagaaggaaa aattatcgag tgtcgacaga catcattctg tggagatcaa aattgaaaaa     1560

actgtaatta agaaggaaga gaagattgag aagaaggagg aaaaaaagcc tgaagacatt     1620

aagaaggaag aaaaagacca ggatgagctg aaacccggac ctacaaatcg gtctagagtc     1680

accaaatcag gaagcagagg aatggagcgg acggtcgtga tggataaatc gaaaggagag     1740

cccgtcatta gcgtgaaaac cacaagcagg tccaaagaga gaagctccaa gagtcaggat     1800

cgcaagtcag aaagcaaaga aaagagagac atcttgtcgt ttgataaaat caaagaacaa     1860

agggagagag agcgccagag gcagcgggaa cgggagatcc gcgaaacgga gaggcggcgg     1920

gagcgcgagc agcgggagcg ggagcaacgc ctcgaggcct tccatgagcg gaaggagaag     1980

gcccggctac agcgggaacg cctgcagctc gagtgccagc gccagcggct ggagcgggag     2040

cgcatggagc gggagcggct ggagcgcgag cgcatgcgcg tggagcgtga gcgcaggaag     2100

gagcaggagc gcatccaccg cgagcgcgag gagctgcggc gccagcagga gcagctgcgt     2160

tacgagcagg agcggcggcc cgggcggagg ccctacgacc tggaccgacg agatgatgcc     2220

tattggccag aaggaaagcg tgtggcaatg gaggaccgat atcgtgcaga ctttccccgg     2280

ccagaccacc gctttcacga cttcgatcat cgagaccggg gccagtacca ggaccacgcc     2340

atcgacaggc gggagggttc gaggccaatg atgggagacc accgggatgg gcagcactat     2400

ggagatgacc gccatggcca cggaggaccc ccagagcgcc acggccggga ctcccgtgat     2460

ggctgggggg gctacggctc cgacaagagg ctgagtgaag gccgggggct gccccctccc     2520

cccaggggtg gccgtgactg gggagagcac aaccagcggc tagaggagca ccaggcacgc     2580

gcctggcagg gtgccatgga cgcaggcgcg gctagccggg agcacgccag gtggcaaggt     2640

ggcgagaggg gcctgtctgg gccctcgggg ccggggcaca tggcaagccg cggtggagtg     2700

gcggggcgag gcggctttgc acaaggtgga cattcccagg gccacgtggt gccaggtggc     2760

ggactggaag gtggcggagt ggccagccag gaccggggca gcagagtccc tcacccacac     2820

cctcatcccc ccccgtaccc ccacttcacc cgccgctact aa                        2862


<210>  502
<211>  2292
<212>  DNA
<213>  Homo sapiens;

<400>  502
atggatcatt tgaacgaggc aactcagggg aaagaacatt cagaaatgtc taacaatgtg       60

agtgatccga agggtccacc agccaagatt gcccgcctgg agcagaacgg gagcccgcta      120

ggaagaggaa ggcttgggag tacaggtgca aaaatgcagg gagtgccttt aaaacactcg      180

ggccatctga tgaaaaccaa ccttaggaaa ggaaccatgc tgccagtttt ctgtgtggtg      240

gaacattatg aaaacgccat tgaatatgat tgcaaggagg agcatgcaga atttgtgctg      300

gtgagaaagg atatgctttt caaccagctg atcgaaatgg cattgctgtc tctaggttat      360

tcacatagct ctgctgccca ggccaaaggg ctaatccagg ttggaaagtg gaatccagtt      420

ccactgtctt acgtgacaga tgcccctgat gctacagtag cagatatgct tcaagatgtg      480

tatcatgtgg tcacattgaa aattcagtta cacagttgcc ccaaactaga agacttgcct      540

cccgaacaat ggtcgcacac cacagtgagg aatgctctga aggacttact gaaagatatg      600

aatcagagtt cattggccaa ggagtgcccc ctttcacaga gtatgatttc ttccattgtg      660

aacagtactt actatgcaaa tgtctcagca gcaaaatgtc aagaatttgg aaggtggtac      720

aaacatttca agaagacaaa agatatgatg gttgaaatgg atagtctttc tgagctatcc      780

cagcaaggcg ccaatcatgt caattttggc cagcaaccag ttccagggaa cacagccgag      840

cagcctccat cccctgcgca gctctcccat ggcagccagc cctctgtccg gacacctctt      900

ccaaacctgc accctgggct cgtatcaaca cctatcagtc ctcaattggt caaccagcag      960

ctggtgatgg ctcagctgct gaaccagcag tatgcagtga atagactttt agcccagcag     1020

tccttaaacc aacaatactt gaaccaccct ccccctgtca gtagatctat gaataagcct     1080

ttggagcaac aggtttcgac caacacagag gtgtcttccg aaatctacca gtgggtacgc     1140

gatgaactga aacgagcagg aatctcccag gcggtatttg cacgtgtggc ttttaacaga     1200

actcagggct tgctttcaga aatcctccga aaggaagagg accccaagac tgcatcccag     1260

tctttgctgg taaaccttcg ggctatgcag aatttcttgc agttaccgga agctgaaaga     1320

gaccgaatat accaggacga aagggaaagg agcttgaatg ctgcctcggc catgggtcct     1380

gcccccctca tcagcacacc acccagccgt cctccccagg tgaaaacagc tactattgcc     1440

actgaaagga atgggaaacc agagaacaat accatgaaca ttaatgcttc catttatgat     1500

gagattcagc aggaaatgaa gcgtgctaaa gtgtctcaag cactgtttgc aaaggttgca     1560

gcaaccaaaa gccagggatg gttgtgcgag ctgttacgct ggaaagaaga tccttctcca     1620

gaaaacagaa ccctgtggga gaacctctcc atgatccgaa ggttcctcag tcttcctcag     1680

ccagaacgtg atgccattta tgaacaggag agcaacgcgg tgcatcacca tggcgacagg     1740

ccgccccaca ttatccatgt tccagcagag cagattcagc aacagcagca gcaacagcaa     1800

cagcagcagc agcagcagca ggcaccgccg cctccacagc cacagcagca gccacagaca     1860

ggccctcggc tccccccacg gcaacccacg gtggcctctc cagcagagtc agatgaggaa     1920

aaccgacaga agacccggcc acgaacaaaa atttcagtgg aagccttggg aatcctccag     1980

agtttcatac aagacgtggg cctgtaccct gacgaagagg ccatccagac tctgtctgcc     2040

cagctcgacc ttcccaagta caccatcatc aagttctttc agaaccagcg gtactatctc     2100

aagcaccacg gcaaactgaa ggacaattcc ggtttagagg tcgatgtggc agaatataaa     2160

gaagaggagc tgctgaagga tttggaagag agtgtccaag ataaaaatac taacaccctt     2220

ttttcagtga aactagaaga agagctgtca gtggaaggaa acacagacat taatactgat     2280

ttgaaagact ga                                                         2292


<210>  503
<211>  1200
<212>  DNA
<213>  Homo sapiens;

<400>  503
atggcggaac gcaggagaca caagaagcgg atccaggaag ttggtgaacc atctaaagaa       60

gagaaggctg tggccaagta tcttcgattc aactgtccaa caaagtccac caatatgatg      120

ggtcaccggg ttgattattt tattgcttca aaagcagtgg actgtctttt ggattcaaag      180

tgggcaaagg ccaagaaagg agaggaagct ttatttacaa ccagggagtc tgtggttgac      240

tactgcaaca ggcttttaaa gaagcagttt tttcaccgag ccctaaaagt aatgaaaatg      300

aaatatgata aagacataaa gaaagaaaaa gataaaggaa aagctgaaag tggaaaagaa      360

gaagataaaa agagcaagaa agaaaatata aaggatgaga agacaaaaaa agaaaaagag      420

aaaaaaaaag atggtgaaaa ggaagaatcc aaaaaggagg aaactccagg aactcctaaa      480

aagaaggaaa ctaagaaaaa attcaaactt gagccacatg atgatcaggt ttttctggat      540

ggaaatgagg tgtatgtatg gatctatgac ccagttcact ttaaaacatt tgtcatggga      600

ttaattcttg tgattgcagt aatagcggcc accctcttcc ccctttggcc agcagaaatg      660

agagtaggtg tttattacct cagtgtgggt gcaggctgtt ttgtagccag tattcttctc      720

cttgctgttg ctcgatgcat tctatttctc atcatttggc tcataactgg aggaaggcac      780

cacttttggt tcttgccaaa tctgactgct gatgtgggct tcattgactc cttcaggcct      840

ctgtacacac atgaatacaa aggaccaaaa gcagacttaa agaaagatga gaagtctgaa      900

accaaaaagc aacagaagtc cgacagtgag gaaaagtcag acagtgagaa aaaggaagat      960

gaggagggga aagtaggacc aggaaatcat ggaacagaag gctcgggggg agaacggcat     1020

tcagacacgg acagtgacag gagggaagat gatcgatccc agcacagtag tggaaatgga     1080

aatgattttg aaatgataac aaaagaggaa ctggaacagc aaacagatgg ggattgtgaa     1140

gaggatgagg aagaggaaaa tgatggagaa acacctaaat cttcacatga aaaatcataa     1200


<210>  504
<211>  2589
<212>  DNA
<213>  Homo sapiens;

<400>  504
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca       60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcacctggtg      120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac      180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag      240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag      300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc      360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta      420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca      480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat      540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa      600

tatgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgacgtgat ccgaaaaagc      660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg      720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtgtg caagggggac      780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc      840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg      900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg      960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg     1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc     1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac     1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg     1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tgtgaactac     1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt     1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc     1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca     1440

aagaagggca acaggtttgt ctatgctggc tctaactcgg gcgtggtcca ggccccgctg     1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc     1560

gcctggagcc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg     1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggataaaag taaaggaagt     1680

taccggcagc attttttcaa gcacggtggc acagcggaac tgaaatgctc ccaaaaatcc     1740

aacctggccc gggtcttttg gaagttccag aatggcgtgt tgaaggccga gagccccaag     1800

tacggtctta tgggcagaaa aaacttgctc atcttcaact tgtcagaagg agacagtggg     1860

gtgtaccagt gcctgtcaga ggagagggtt aagaacaaaa cggtcttcca agtggtcgcc     1920

aagcacgtcc tggaagtgaa ggtggttcca aagcccgtag tggcccccac cttgtcagtt     1980

gttcagacag aaggtagtag gattgccacc aaagtgttgg tggcatccac ccaagggtct     2040

tctcccccaa ccccagccgt gcaggccacc tcctccgggg ccatcaccct tcctcccaag     2100

cctgcgccca ccggcacatc ctgcgaacca aagatcgtca tcaacacggt cccccagctc     2160

cactcggaga aaaccatgta tcttaagtcc agcgacaacc gcctcctcat gtccctcttc     2220

ctcttcttct ttgttctctt cctctgcctc tttttctaca actgctataa gggatacctg     2280

cccagacagt gcttgaaatt ccgctcggcc ctactaattg ggaagaagaa gcccaagtca     2340

gatttctgtg accgtgagca gagcctgaag gagacgttag tagagccagg gagcttctcc     2400

cagcagaatg gggagcaccc caagccagcc ctggacaccg gctatgagac cgagcaagac     2460

accatcacca gcaaagtccc cacggatagg gaggactcac agaggatcga cgacctttct     2520

gccagggaca agccctttga cgtcaagtgt gagctgaagt tcgctgactc agacgcagat     2580

ggagactga                                                             2589


<210>  505
<211>  1422
<212>  DNA
<213>  Homo sapiens;

<400>  505
atgggggctg tgctgggtgt cttctccctc gccagctggg ttccatgcct ctgcagcggt       60

gcctcatgtt tgctgtgtag ttgctgtcct aacagtaaga attccacggt gactcgcctc      120

atttatgctt tcattctcct cctgagcact gtcgtatcct atatcatgca gagaaaagag      180

atggaaactt acttgaagaa gattcctgga ttttgtgaag ggggatttaa aatccatgag      240

gctgatataa atgcagataa agattgtgat gtgctggttg gttataaagc tgtgtatcgg      300

atcagctttg ccatggccat ctttttcttt gtcttttctc tgctcatgtt caaagtaaaa      360

acaagtaaag atctccgagc ggcagtacac aatgggtttt ggttcttcaa aattgctgcc      420

cttattggaa tcatggttgg ctctttctac atccctgggg gctatttcag ctcagtctgg      480

tttgttgttg gcatgatagg ggccgccctc ttcatcctca ttcagctggt gctgctggta      540

gattttgctc attcttggaa tgaatcatgg gtaaatcgaa tggaagaagg aaacccaagg      600

ttgtggtatg ctgctttact gtctttcaca agcgcctttt atatcctgtc aatcatctgt      660

gtcgggctgc tctatacata ttacaccaaa ccagatggct gcacagaaaa caagttcttc      720

atcagtatta acctgatcct ttgcgttgtg gcttctatta tatcgatcca cccaaaaatt      780

caggaacacc agcctcgctc cggcctcttg cagtcctccc tcatcaccct ctacactatg      840

tacctcacct ggtcagccat gtccaatgaa cctgatcgtt cctgcaatcc caacctgatg      900

agctttatta cacgcataac tgcaccaacc ctggctcctg gaaattcaac tgctgtggtc      960

cctaccccta ctccaccatc aaagagtggg tctttactgg attcagataa ttttattgga     1020

ctgtttgtct ttgttctctg cctcttgtat tctagcatcc gcacttccac taatagccaa     1080

gtagacaagc tgaccctgtc agggagtgac agcgtcatcc ttggtgatac aactaccagt     1140

ggtgccagtg atgaagaaga tggacagcct cggcgggctg tggacaacga gaaagaggga     1200

gtgcagtata gctactcctt attccacctc atgctctgct tggcttcctt gtacatcatg     1260

atgaccctga ccagctggta cagccctgat gcaaagtttc agagcatgac cagcaagtgg     1320

ccagctgtgt gggtcaagat cagctccagc tgggtctgcc tcctgcttta cgtctggacc     1380

cttgtggctc cacttgtcct caccagtcgg gacttcagct ga                        1422


<210>  506
<211>  1371
<212>  DNA
<213>  Homo sapiens;

<400>  506
atgtcagctc agtgctgtgc gggccagctg gcctgctgct gtgggtctgc aggctgctct       60

ctctgctgtg attgctgccc caggattcgg cagtccctca gcacccgctt catgtacgcc      120

ctctacttca ttctggtcgt cgtcctctgc tgcatcatga tgtcaacaac cgtggctcac      180

aagatgaaag agcacattcc tttttttgaa gatatgtgta aaggcattaa agctggtgac      240

acctgtgaga agctggtggg atattctgcc gtgtatagag tctgttttgg aatggcttgt      300

ttcttcttta tcttctgtct actgaccttg aaaatcaaca acagcaaaag ttgtagagct      360

catattcaca atggcttttg gttctttaaa cttctgctgt tgggggccat gtgctcagga      420

gctttcttca ttccagatca ggacaccttt ctgaacgcct ggcgctatgt gggagccgtc      480

ggaggcttcc tcttcattgg catccagctc ctcctgctcg tggagtttgc acataagtgg      540

aacaagaact ggacagcagg cacagccagt aacaagctgt ggtacgcctc cctggccctg      600

gtgacgctca tcatgtattc cattgccact ggaggcttgg ttttgatggc agtgttttat      660

acacagaaag acagctgcat ggaaaacaaa attctgctgg gagtaaatgg aggcctgtgc      720

ctgcttatat cattggtagc catctcaccc tgggtccaaa atcgacagcc acactcgggg      780

ctcttacaat caggggtcat aagctgctat gtcacctacc tcaccttctc agctctgtcc      840

agcaaacctg cagaagtaga tgaacatggg aaaaatgtta caatctgtgt gcctgacttt      900

ggtcaagacc tgtacagaga tgaaaacttg gtgactatac tggggaccag cctcttaatc      960

ggatgtatct tgtattcatg tttgacatca acaacaagat cgagttctga cgctctgcag     1020

gggcgatacg cagctcctga attggagata gctcgctgtt gtttttgctt cagtcctggt     1080

ggagaggaca ctgaagagca gcagccgggg aaggagggac cacgggtcat ttatgacgag     1140

aagaaaggca ccgtctacat ctactcctac ttccacttcg tgttcttcct agcttccctg     1200

tatgtgatga tgaccgtcac caactggttc aaatggagtc ccactctgtt gcccaggctg     1260

gagtacagtg gcatgatctt ggctcactgc aacctccacc tcccagatgt caagcgattc     1320

tcttgcctca gcctcccaag tagctggggt tacaggcatg tgccaccatg a              1371


<210>  507
<211>  945
<212>  DNA
<213>  Homo sapiens;

<400>  507
atgttgggta aaggaggaaa acggaagttt gatgagcatg aagatgggct ggaaggcaaa       60

atcgtgtctc cctgtgacgg tccatccaag gtgtcttaca ccttacagcg ccagactatc      120

ttcaacattt cccttatgaa actctataac cacaggcccc tgacagagcc cagcttgcaa      180

aagaccgttt taattaacaa catgttgagg cggatccagg aggaactcaa acaggaaggc      240

agcctgaggc ccatgttcac cccctcctcc cagcccacca ccgagcccag cgacagctac      300

cgagaggccc cgccggcctt cagccacctg gcgtccccgt cctcccaccc ctgcgacctc      360

ggaagcacta cgcccctgga ggcctgcctc accccggcct cactgctcga ggacgacgat      420

gacacgtttt gcacctccca ggccatgcag cccacggctc ccaccaaact gtcacctcca      480

gccctcttgc cagaaaagga cagtttctcc tctgccttgg acgagatcga ggagctctgt      540

cccacatcta cctccacaga ggcggccacg gctgcgactg acagtgtgaa agggacctcc      600

agcgaggctg gcacccagaa actcgacggt cctcaagaga gccgcgcaga tgactcaaaa      660

ctgatggact ctctgcctgg gaattttgaa ataacgacgt ccacgggttt cctgacagac      720

ttgaccctgg atgacatcct gtttgctgac attgatacgt ccatgtatga ttttgacccc      780

tgcacttcct catcagggac agcctcaaaa atggcccctg tgtctgccga cgacctcctc      840

aaaactctgg ctccttacag cagtcagcct gtcaccccaa gtcagccttt caaaatggac      900

ctcacagagc tggaccacat catggaggtg cttgttgggt cctaa                      945


<210>  508
<211>  1656
<212>  DNA
<213>  Homo sapiens;

<400>  508
atggctgaag gagagaatga agtgagatgg gatggactct gcagcagaga ttcaactact       60

agggagacag cattggaaaa cattaggcaa accattttga ggaaaaccga gtatcttcgt      120

tcggtgaaag aaacacctca tcgtccatca gacgggcttt caaataccga gtcttcggat      180

gggttgaata agctacttgc tcatctgctt atgctttcta agaggtgtcc cttcaaagat      240

gtgagagaga aaagtgagtt tattctgaag agcatccagg aacttggcat tagaattcct      300

cgaccactag gacagggacc aagcagattc atcccagaaa aggagatcct ccaagtgggg      360

agtgaagacg cacagatgca tgctttattt gcagattctt ttgctgcttt gggccgtttg      420

gataacatta cgttagtgat ggttttccac ccacaatatt tagaaagttt cttaaaaact      480

cagcactatc tactgcaaat ggatgggccg ttacccctac attatcgtca ctacattgga      540

ataatggctg cggcaagaca tcagtgctcc tacttagtga acctgcatgt aaatgatttc      600

cttcatgttg gtggggaccc caagtggctc aatggtttag agaatgctcc tcaaaaacta      660

cagaatttag gagaacttaa caaagtgtta gcccatagac cttggcttat taccaaagaa      720

cacattgagg gacttttaaa agctgaagag cacagctggt cccttgcgga attggtacat      780

gcagtagttt tactcacaca ctatcattct cttgcctcat tcacattcgg ctgtggaatc      840

agtccagaaa ttcattgtga tggtggccac acattcagac ctccttctgt tagcaactac      900

tgcatctgtg acattacaaa tggcaatcac agtgtggatg agatgccggt caactcagca      960

gaaaatgttt ctgtaagtga ttctttcttt gaggttgaag ccctcatgga aaagatgagg     1020

cagttacagg aatgtcgaga tgaagaagag gcaagtcagg aagagatggc ttcacgtttt     1080

gaaatagaaa aaagagagag tatgtttgtc ttctcttcag atgatgaaga agttacacca     1140

gcaagagctg tatctcgtca ttttgaggat actagttatg gctataaaga tttctctaga     1200

catgggatgc atgttccaac atttcgtgtc caggactatt gctgggaaga tcatggttat     1260

tctttggtaa atcgccttta tccagatgtg ggacagttga ttgatgaaaa atttcacatt     1320

gcttacaatc ttacttataa tacaatggca atgcacaaag atgttgatac ctcaatgctt     1380

agacgggcaa tttggaacta tattcactgc atgtttggaa taagatatga tgattatgac     1440

tatggtgaaa ttaaccagct attggatcgt agctttaaag tttatatcaa aactgttgtt     1500

tgcactcctg aaaaggttac caaaagaatg tatgatagct tctggaggca gttcaagcac     1560

tctgagaagg ttcatgttaa tctgcttctt atagaagcta ggatgcaagc agaactcctt     1620

tatgctctga gagccattac ccgctatatg acctga                               1656


<210>  509
<211>  7695
<212>  DNA
<213>  Homo sapiens;

<400>  509
atgaagcagc tgcagccgca gccgcctccg aagatggggg atttctacga cccggagcac       60

ccgacccctg aagaagaaga aaatgaggca aagattgaaa atgtgcagaa aacaggtttc      120

atcaaaggac caatgttcaa aggtgttgct tctagtcgat ttttgcccaa aggcaccaaa      180

acaaaagtta atttggaaga acagggacga cagaaggtgt cattcagctt cagccttaca      240

aagaaaactt tgcagaatag gtttctcact gcacttggca atgaaaagca aagtgatact      300

ccaaaccctc cagctgtacc tcttcaggta gactcgactc ctaaaatgaa aatggaaatt      360

ggtgatacct tatctactgc agaagaatct tccccaccaa agtcaagggt ggaattgggc      420

aaaattcatt ttaagaaaca tctgcttcat gtaacatcca ggccactgct ggctactacc      480

acagcagtag catctccacc tactcatgca gcaccattac cagcagtgat agcagaatca      540

acaactgtag actcaccgcc ctcatctccg cctccaccgc ctccacctgc ccaagccaca      600

acactctcat caccagcacc agtaacagag ccagtggcct tgccacatac accaataaca      660

gttctaatgg cagcaccagt acccttacca gtagatgtag cagttagatc tctgaaagaa      720

ccaccaatta taattgtacc agaatcttta gaagcagata ctaagcagga cactatatct      780

aatagtttag aagaacacgt aactcaaata ttgaatgagc aagcagatat ttcctcaaaa      840

aaagaagatt cccatattgg gaaggatgaa gaaattccag atagttctaa gattagtctg      900

agctgtaaaa aaacaggttc taagaagaaa tcctcacaat ctgaaggcat ctttcttggt      960

tcagaatctg atgaagattc tgtacggact tcttcaagtc aaagatcaca tgatttaaaa     1020

ttttcagcaa gcattgaaaa ggaaagagat tttaaaaaga gctcagcacc tttaaaaagt     1080

gaggatctag ggaaaccttc acgatctaaa acagacagag atgataaata ttttagctat     1140

tcaaaacttg aaagagatac tcggtatgta tcttcccgat gtagatcaga aagagagcga     1200

cggcggagca gatctcactc taggtctgag agaggctcta gaactaattt atcctattcc     1260

aggtcagaac gatctcatta ttatgactct gatcgtcgct accataggag ctccccttat     1320

cgagagagga cgcgctattc tcggccatac acagataaca gagcacgaga gagttctgac     1380

tcagaagaag agtataagaa gacatactca aggcgtacct catctcattc ctcttcttac     1440

agagacctaa ggacatcatc ctattctaaa tctgatcggg actgtaaaac tgagacctct     1500

tacttagaga tggaaagaag aggcaagtat tcttcaaaac tagaaagaga atctaaaagg     1560

acttcagaaa atgaagcaat taaaagatgt tgttctcccc ctaatgaact gggattccga     1620

cgagggtcat catattctaa gcatgacagt agtgcttccc gttataaatc taccctttca     1680

aaacctatac ccaagtctga taaatttaaa aattctttct gttgtacaga attaaatgaa     1740

gaaatcaaac agtctcattc ttttagttta cagacacctt gttcaaaagg tagtgaatta     1800

agaatgatta ataaaaatcc tgaaagagaa aaggctgggt ctccagctcc atcaaatcga     1860

ttaaatgatt cacctacttt aaaaaagcta gatgaattgc ctatttttaa gtccgaattt     1920

ataacacatg atagccatga tagtattaag gaattagact ctttatctaa agtgaagaat     1980

gatcaattaa gaagtttttg tcccatagaa ttaaatataa atggatctcc tggggcagaa     2040

tctgatttgg caacattttg cacttctaaa actgatgctg ttttaatgac ttctgatgat     2100

agtgtgactg gatcggaatt atcccctttg gtcaaagcat gcatgctttc atcaaatgga     2160

tttcagaata ttagtaggtg caaagaaaaa gacttggatg atacctgcat gctgcataag     2220

aagtcagaaa gcccatttag agaaacagaa cctctggtgt caccacacca agataaactc     2280

atgtctatgc cagttatgac tgtggattat tccaaaacag tagttaaaga accagttgat     2340

acgagggttt cttgctgcaa aaccaaagat tcagacatat actgtacttt gaacgatagc     2400

aacccttctt tgtgtaactc tgaagctgaa aatattgagc cttcagttat gaagatttct     2460

tcaaatagct ttatgaatgt gcatttggaa tcaaaaccag ttatatgtga tagtagaaat     2520

ttgacagatc actcaaaatt tgcatgtgaa gaatataagc agagcatcgg tagcactagt     2580

tcagcttctg ttaatcattt tgatgattta tatcaaccta ttgggagttc aggtattgct     2640

tcatctcttc agagtcttcc accaggaata aaggtggaca gtctaactct cttgaaatgc     2700

ggagagaaca catctccagt tctggatgca gtgctaaaga gtaaaaaaag ttcagagttt     2760

ttaaagcatg cagggaaaga aacaatagta gaagtaggta gtgaccttcc tgattcagga     2820

aagggatttg cttccaggga gaacaggcgt aataatgggt tatctgggaa atgtttgcaa     2880

gaggctcaag aagaagggaa ttccatattg cctgaaagaa gaggaagacc agaaatctct     2940

ttagatgaaa gaggagaagg aggacatgtg catacttctg atgactcaga agttgtattt     3000

tcttcttgtg atttgaattt aaccatggaa gacagtgatg gtgtaactta tgcattaaag     3060

tgtgacagta gtggtcatgc cccagaaatt gtgtctacag ttcatgaaga ttattctggc     3120

tcttctgaaa gttcaaatga tgaaagtgat tcagaagata cagattcgga tgatagcagt     3180

attccaagaa accgtctcca gtctgttgtg gttgtgccaa agaattctac tttgcccatg     3240

gaagaaacaa gtccttgttc ttctcggagc agtcaaagtt atagacacta ttctgaccat     3300

tgggaagatg agagattgga gtcaaggaga catttgtatg aggaaaaatt tgaaagtata     3360

gcaagtaaag cctgtcctca aactgataag tttttccttc ataaaggaac agagaagaat     3420

ccggaaattt cttttacaca gtccagtaga aaacaaatag ataatcgcct gcctgaactt     3480

tctcatcctc agagtgatgg ggttgatagt acaagtcata cagatgtgaa atctgaccct     3540

ctgggtcacc caaattcaga ggaaaccgtg aaagccaaaa taccttctag gcagcaagaa     3600

gagctgccaa tttattcttc tgattttgaa gatgtcccaa ataagtcttg gcaacagacc     3660

actttccaaa acaggccaga tagtagactg ggaaaaacag aattgagttt ttcttcctct     3720

tgtgagatac cacatgtgga tggcttgcac tcatcagaag agctcagaaa cttaggttgg     3780

gacttctctc aagaaaagcc ttctaccacg tatcagcaac ctgacagtag ctatggagct     3840

tgtggtggac acaagtatca gcaaaatgca gaacagtatg gtgggacacg tgattactgg     3900

caaggcaatg gttactggga tccaagatca ggtagacctc ctggaactgg ggttgtgtat     3960

gatcgaactc aaggacaagt accagattcc ctaacagatg atcgtgaaga agaggagaat     4020

tgggatcaac aggatggatc ccatttttca gaccagtccg ataaatttct tctatccctt     4080

cagaaagaca aggggtcagt gcaagcacct gaaataagca gcaattccat taaggacact     4140

ttagctgtga atgaaaagaa agatttttca aaaaacttag aaaaaaatga tatcaaagat     4200

agagggcctc ttaaaaaaag gaggcaggaa atagagagtg attctgaaag tgatggtgag     4260

cttcaggaca gaaagaaagt tagagtggag gtagagcagg gagagacatc agtgccccca     4320

ggttcagcac tggttgggcc ctcctgtgtc atggatgact tcagggaccc acagcgatgg     4380

aaggaatgtg ccaagcaagg gaaaatgcca tgttactttg atcttattga agaaaatgtt     4440

tatttaacag aaagaaagaa gaataaatct catcgagata ttaagcgaat gcagtgtgag     4500

tgtacacctc tttctaaaga tgaaagagct caaggtgaaa tagcatgtgg ggaagattgt     4560

cttaatcgtc ttctcatgat tgaatgttct tctcggtgtc caaatgggga ttattgttcc     4620

aatagacggt ttcagagaaa acagcatgca gatgtggaag tcatactcac agaaaagaaa     4680

ggctggggct tgagagctgc caaagacctt ccttcgaaca cctttgtcct agaatattgt     4740

ggagaggtac tcgatcataa agagtttaaa gctcgagtga aggagtatgc acgaaacaaa     4800

aacatccatt actatttcat ggccctgaag aatgatgaga taatagatgc cactcaaaaa     4860

ggaaattgct ctcgtttcat gaatcacagc tgtgaaccaa attgtgaaac ccaaaaatgg     4920

actgtgaacg gacaactgag ggttgggttt tttaccacca aactggttcc ttcaggctca     4980

gagttaacgt ttgactatca gttccagaga tatggaaaag aagcccagaa atgtttctgc     5040

ggatcagcca attgccgggg ttacctggga ggagaaaaca gagtcagcat cagagcagca     5100

ggagggaaaa tgaagaagga acgatctcgt aagaaggatt cagtggatgg agagctagaa     5160

gctctgatgg aaaatggtga gggtctctct gataaaaacc aggtgctcag cttatcccgg     5220

ctaatggtta gaattgaaac tttggagcag aaacttacct gtctggaact catacagaac     5280

acacactcac agtcctgcct gaagtccttt ctggaacgtc atgggctgtc tttgttgtgg     5340

atctggatgg cagagctagg tgacggccgg gaaagtaacc agaagcttca ggaagagatt     5400

ataaagactt tggaacactt gcccattcct actaaaaata tgttggagga aagcaaagta     5460

cttccaatta ttcaacgctg gtctcagact aagactgctg tccctccgtt gagtgaagga     5520

gatgggtatt ctagtgagaa tacatcgcgt gctcatacac cactcaacac acctgatcct     5580

tccaccaagc tgagcacaga agctgacaca gacactccca agaaactaat gtttcgcaga     5640

ctgaaaatta taagtgaaaa tagcatggac agtgcaatct ctgatgcaac cagtgagcta     5700

gaaggcaagg atggcaaaga ggatcttgat caattagaaa atgtccctgt agaggaagag     5760

gaagaattgc agtcacaaca gctactccca caacagctgc ctgaatgcaa agttgatagt     5820

gaaaccaaca tagaagctag taagctacct acatctgaac cagaagctga cgctgaaata     5880

gagcccaaag agagcaacgg cacaaaacta gaagaaccta ttaatgaaga aacaccatcc     5940

caagatgaag aggagggtgt gtctgatgtg gagagtgaaa ggagccaaga acagccagat     6000

aaaacagtgg atataagtga tttggccacc aaactcctgg acagttggaa agacctaaag     6060

gaggtatatc gaattccaaa gaaaagtcaa actgaaaagg aaaacacaac aactgaacga     6120

ggaagggatg ctgttggctt cagagatcaa acacctgccc cgaagactcc taataggtca     6180

agagagagag acccagacaa gcaaactcaa aataaagaga aaaggaaacg aagaagctcc     6240

ctctcaccac cctcttctgc ctatgagcgg ggaacaaaaa ggccagatga cagatatgat     6300

acaccaactt ctaaaaagaa agtacgaatt aaagaccgca ataaactttc tacagaggaa     6360

cgccggaagt tgtttgagca agaggtggct caacgggagg ctcagaaaca acagcaacag     6420

atgcagaacc tgggaatgac atcaccactg ccctatgact ctcttggtta taatgccccg     6480

catcatccct ttgctggtta cccaccaggt tatcccatgc aggcctatgt ggatcccagc     6540

aaccctaatg ctggaaaggt gctcctgccc acacccagca tggacccagt gtgttctcct     6600

gctccttatg atcatgctca gcccttggtg ggacattcta cagaacccct ttctgcccct     6660

ccaccagtac cagtggtgcc acatgtggca gctcctgtgg aagtttccag ttcccagtat     6720

gtggcccaga gtgatggtgt agtacaccaa gactccagcg ttgctgtctt gccagtgccg     6780

gcccccggcc cagttcaggg acagaattat agtgtttggg attcaaacca acagtctgtc     6840

agtgtacagc agcagtactc tcctgcacag tctcaagcaa ccatatatta tcaaggacag     6900

acatgtccaa cagtctatgg tgtgacatca ccttattcac agacaactcc accaattgta     6960

cagagttatg cccagccaag tcttcagtat atccaggggc aacagatttt cacagctcat     7020

ccacaaggag tggtggtaca gccagccgca gcagtgacta caatagttgc accagggcag     7080

cctcagccct tgcagccatc tgaaatggtt gtgacaaata atctcttgga tctgccgccc     7140

ccctctcctc ccaaaccaaa aaccattgtc ttacctccca actggaagac agctcgagat     7200

ccagaaggga agatttatta ctaccatgtg atcacaaggc agactcagtg ggatcctcct     7260

acttgggaaa gcccaggaga tgatgccagc cttgagcatg aagctgagat ggacctggga     7320

actccaacat atgatgaaaa ccccatgaag gcctcgaaaa agcccaagac agcagaagca     7380

gacacctcca gtgaactagc aaagaaaagc aaagaagtat tcagaaaaga gatgtcccag     7440

ttcatcgtcc agtgcctgaa cccttaccgg aaacctgact gcaaagtggg aagaattacc     7500

acaactgaag actttaaaca tctggctcgc aagctgactc acggtgttat gaataaggag     7560

ctgaagtact gtaagaatcc tgaggacctg gagtgcaatg agaatgtgaa acacaaaacc     7620

aaggagtaca ttaagaagta catgcagaag tttggggctg tttacaaacc caaagaggac     7680

actgaattag agtga                                                      7695


<210>  510
<211>  1728
<212>  DNA
<213>  Homo sapiens;

<400>  510
atgaacgggc ctgccctgca gccctcctcg ccctcttccg cgccctcagc ctccccggcg       60

gcggccccgc ggggctggag cgagttctgt gagttgcacg ccgtagcggc ggcccgggag      120

ctggcccgcc agtactggct gttcgcccgg gagcatccgc agcacgcgcc gctgcgcgcc      180

gagctggtgt cgctgcagtt caccgacctc ttccagcgct acttctgccg cgaggtgcgc      240

gacggacggg cgccgggccg cgactaccgg gacacaggcc gtgggccccc agccaaggcc      300

gaggcgtccc cggagccagg ccccggcccc gccgcccctg gcctgcccaa ggcccgcagc      360

tctgaggagc tggccccgcc gcggccgccc gggccctgct ccttccagca ctttcgccgc      420

agcctccgcc acatcttccg ccgccgctcg gccggggagc tgccagcggc ccacaccgct      480

gccgcccccg ggacccccgg agaggctgct gagacccccg cccggcctgg cctggccaag      540

aagttcctgc cctggagcct ggcccgggag ccgccacccg aggcgctgaa ggaggcggtg      600

ctgcgctaca gcctggccga cgaggcctcc atggacagcg gggcacgctg gcagcgcggg      660

aggctggcgc tgcgccgggc cccgggcccc gatggccccg accgcgtgct ggagctcttc      720

gacccaccca agagttcaag gcccaagcta caagcagctt gctccagcat ccaggaggtc      780

cggtggtgca cacggcttga gatgcctgac aacctttaca cctttgtgct gaaggtgaag      840

gaccggacag acatcatctt tgaggtggga gacgagcagc agctgaattc atggatggct      900

gagctctcgg agtgcacagg ccgagggctg gagagcacag aagcagagat gcatattccc      960

tcagccctag agcctagcac gtccagctcc ccaaggggca gcacagattc ccttaaccaa     1020

ggtgcttctc ctggggggct gctggacccg gcctgccaga agacggacca tttcctgtcc     1080

tgctacccct ggttccacgg ccccatctcc agagtgaaag cagctcagct ggttcagctg     1140

cagggccctg atgctcatgg agtgttcctg gtgcggcaga gcgagacgcg gcgtggggaa     1200

tacgtgctca ctttcaactt tcaggggata gccaagcacc tgcgcctgtc gctgacagag     1260

cggggccagt gccgtgtgca gcacctccac tttccctcgg tcgtggacat gctccaccac     1320

ttccagcgct cgcccatccc actcgagtgc ggcgccgcct gtgatgtccg gctctccagc     1380

tacgtggtag tcgtctccca accaccaggt tcctgcaaca cggtcctctt ccctttctcc     1440

cttcctcact gggattcaga gtcccttcct cactggggtt cagagttggg ccttccccac     1500

cttagttctt ctggctgtcc ccgggggctc agcccagagg gtctcccagg gcgatcctca     1560

ccccccgagc agatcttcca cctggtgcct tcgcccgaag aactggccaa cagcctgcag     1620

cacctggagc atgagcctgt gaatcgagcc cgggactcgg actacgaaat ggactcatcc     1680

tcccggagcc acctgcgggc catagacaat cagtacacac ctctctga                  1728


<210>  511
<211>  2112
<212>  DNA
<213>  Homo sapiens;

<400>  511
atgactgctg tgggccgaag gtgccccgcg ctggggtccc gaggggctgc tggagagcca       60

gaggctggca gcgactatgt gaagttctcc aaggagaagt acatcctgga ctcatcgcca      120

gagaaactcc acaaggaatt ggaggaggag ctcaaactca gcagcacgga tctccgcagc      180

catgcctggt accatggccg catcccccga gaggtctcgg agaccttggt acaacgcaac      240

ggcgacttcc tcatccggga ctcactcacc agcctgggcg actatgtgct cacgtgccgc      300

tggcgcaacc aggccttgca cttcaagatc aacaaggtgg tggtgaaggc aggcgagagc      360

tacacacaca tccagtacct gtttgagcag gagagctttg accacgtgcc cgccctcgtg      420

cgctatcatg tgggcagccg caaggctgtg tcagagcaga gtggtgccat catctactgc      480

ccggtgaacc gcaccttccc actgcgctac ctcgaggcca gctatggcct gggacagggg      540

agtagcaagc ctgctagccc cgtcagcccc tcaggcccca agggcagcca catgaagcgg      600

cgcagcgtca ccatgaccga tgggctcact gctgacaagg tcacccgcag cgatggctgc      660

cccaccagta cgtcgctgcc ccgccctcgg gactccatcc gcagctgtgc cctcagcatg      720

gaccagatcc cagacctgca ctcacccatg tcgcccatct ccgagagccc tagctcccct      780

gcctacagca ctgtaacccg tgtccatgcc gcccctgcag ccccttctgc cacagcattg      840

cctgcctccc ctgtcgcccg ccgttccagt gagccccagc tgtgtcccgg aagtgcccca      900

aagacccatg gggagtcaga caagggcccc cacaccagcc cctcccacac ccttggcaag      960

gcctccccgt caccatcact cagcagctac agtgacccgg actctggcca ctactgccag     1020

ctccagcctc ccgtgcgtgg cagccgagag tgggcagcga ctgagacctc cagccagcag     1080

gccaggagct atggggagag gctaaaggaa ctgtcagaaa atggggcccc tgaaggggac     1140

tggggcaaga ccttcacagt ccccatcgtg gaagtcactt cttccttcaa cccggccacc     1200

ttccagtcac tactgatccc cagggataac cggccactgg aggtgggcct tctgcgcaag     1260

gtcaaggagc tgctggcaga agtggatgcc cggacgctgg cccggcatgt caccaaggtg     1320

gactgcctgg ttgctaggat actgggcgtt accaaggaga tgcagaccct aatgggagtc     1380

cgctggggca tggaactgct caccctcccc catggccggc agctacgcct agacctgctg     1440

gaaaggttcc acaccatgtc catcatgctg gccgtggaca tcctgggctg caccggctct     1500

gcggaggagc gggcagcgct gctgcacaag accattcagc tggcggccga gctgcggggg     1560

actatgggca acatgttcag cttcgcggcg gtcatgggtg ccctggacat ggcccagatt     1620

tctcggctgg agcagacatg ggtgaccctg cggcagcgac acacagaggg tgccatcctg     1680

tacgagaaga agctcaagcc ttttctcaag agcctcaacg agggcaaaga aggcccgccg     1740

ctgagcaaca ccacgtttcc tcatgtgctg cccctcatca ccctgctgga gtgtgactcg     1800

gccccaccag agggccctga gccctggggc agcacggagc acggcgtgga ggtggtgctg     1860

gctcacctgg aggccgcccg cacagtggca caccacggag gcctgtacca caccaatgct     1920

gaagtcaagc tgcaggggtt ccaggcccgg ccggagctcc tggaggtgtt cagcacggag     1980

ttccagatgc gccttctctg gggcagtcag ggtgccagca gcagccaggc ccggcgctat     2040

gagaagttcg acaaggtcct cactgccctg tcccacaagc tggaacctgc tgtccgctcc     2100

agcgagctgt ga                                                         2112


<210>  512
<211>  1515
<212>  DNA
<213>  Homo sapiens;

<400>  512
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      300

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      420

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      480

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      540

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      600

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag      660

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt      720

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa      780

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc      840

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca      900

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta      960

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1020

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1080

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1140

accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa     1200

gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata     1260

acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct     1320

gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg     1380

cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg     1440

acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag     1500

gtcccgagga agtga                                                      1515


<210>  513
<211>  1197
<212>  DNA
<213>  Homo sapiens;

<400>  513
atgcccgtgc cagcctcctg gccccacctt cctagtcctt tcctgctgat gacgctactg       60

ctggggagac tcacaggagt ggcaggtgag gacgagctac aggtgattca gcctgaaaag      120

tccgtatcag ttgcagctgg agagtcggcc actctgcgct gtgctatgac gtccctgatc      180

cctgtggggc ccatcatgtg gtttagagga gctggagcag gccgggaatt aatctacaat      240

cagaaagaag gccacttccc acgggtaaca actgtttcag aactcacaaa gagaaacaac      300

ctggactttt ccatcagcat cagtaacatc accccagcag acgccggcac ctactactgt      360

gtgaagttcc ggaaagggag ccctgacgac gtggagttta agtctggagc aggcactgag      420

ctgtctgtgc gcgccaaacc ctctgccccc gtggtatcgg gccctgcggt gagggccaca      480

cctgagcaca cagtgagctt cacctgcgag tcccatggct tctctcccag agacatcacc      540

ctgaaatggt tcaaaaatgg gaatgagctc tcagacttcc agaccaacgt ggaccccgca      600

ggagacagtg tgtcctacag catccacagc acagccaggg tggtgctgac ccgtggggac      660

gttcactctc aagtcatctg cgagatagcc cacatcacct tgcaggggga ccctcttcgt      720

gggactgcca acttgtctga ggccatccga gttccaccca ccttggaggt tactcaacag      780

cccatgaggg cagagaacca ggcaaacgtc acctgccagg tgagcaattt ctacccccgg      840

ggactacagc tgacctggtt ggagaatgga aatgtgtccc ggacagaaac agcttcgacc      900

ctcatagaga acaaggatgg cacctacaac tggatgagct ggctcctggt gaacacctgt      960

gcccacaggg acgatgtggt gctcacctgt caggtggagc atgatgggca gcaagcagtc     1020

agcaaaagct atgccctgga gatctcagcg caccagaagg agcacggctc agatatcacc     1080

catgaagcag cgctggctcc tactgctcca ctcctcgtag ctctcctcct gggccccaag     1140

ctgctactgg tggttggtgt ctctgccatc tacatctgct ggaaacagaa ggcctga        1197


<210>  514
<211>  2133
<212>  DNA
<213>  Homo sapiens;

<400>  514
atgcagggga agaagccggg cggttcgtcg ggcggcggcc ggagcggcga gctgcagggg       60

gacgaggcgc agaggaacaa gaaaaagaaa aagaaggtgt cctgcttttc caacatcaag      120

atcttcctgg tgtccgagtg cgccctgatg ctggcgcagg gcacggtggg cgcctacctg      180

gtgagcgtcc tgaccaccct ggagcgtagg ttcaacctgc agagcgctga cgtgggtgtg      240

atcgctagca gcttcgagat cgggaacctg gcgctcatcc tcttcgtgag ctacttcggg      300

gcacgcgggc accggccgcg cctgatcggc tgcggcggca tcgtcatggc gctgggcgcg      360

ctgctgtcgg cgctgcccga gttcctgacc caccagtaca agtacgaggc gggcgagatc      420

cgctggggcg ccgagggccg cgacgtctgc gcagccaacg gctcgggcgg cgacgagggg      480

cccgaccccg acctcatctg ccgcaaccgg acggctacca acatgatgta cttgctgctc      540

attggggccc aggtgctcct gggcatcggt gctacccctg tgcagcccct gggcgtctcc      600

tacatcgacg accacgtgcg gaggaaggac tcctcgctct atataggaat cctgttcacg      660

atgctggtat ttggaccagc ctgcgggttt atcctgggct ctttctgtac caaaatctac      720

gtggatgcgg tcttcattga cacaagtaac ctggacatca ctccggacga cccccgctgg      780

atcggagcct ggtggggtgg ctttctgctc tgcggtgcct tactcttctt ctcttccctc      840

ttgatgtttg ggtttccaca gtccctgccc ccgcactcag agcccgccat ggaaagcgag      900

caggccatgc tctccgaaag agaatacgag agacccaagc ccagcaacgg ggtcctgagg      960

caccccctgg agccagacag cagtgcctcc tgtttccagc agctgagagt gatcccgaag     1020

gtcaccaagc acctgctctc aaaccctgtg ttcacctgca tcatcctggc cgcctgcatg     1080

gagattgcag tggtggctgg cttcgctgcc tttttgggga agtacctgga gcagcagttt     1140

aacctcacca cctcttctgc caaccagctg cttgggatga ctgcgatccc gtgtgcttgt     1200

ctgggtatct tcctgggagg tcttttggtg aagaagctca gcctgtctgc cctgggggcc     1260

attcggatgg ccatgctcgt caacctggtg tccactgctt gctacgtctc cttcctcttc     1320

ctgggctgcg acactggccc tgtggctggg gttactgttc cctatggaaa cagcacagca     1380

cctggctcag ccctggaccc ctactcgccc tgcaataata actgtgaatg ccaaaccgat     1440

tccttcactc cagtgtgtgg ggcagatggc atcacctacc tgtctgcctg ctttgctggc     1500

tgcaacagca cgaatctcac gggctgtgcg tgcctcacca ccgtccctgc tgagaacgca     1560

accgtggttc ctggaaaatg ccccagtcct gggtgccaag aggccttcct cactttcctc     1620

tgtgtgatgt gtatctgcag cctgatcggt gccatggcac agacaccctc agtcatcatc     1680

ctcatcagga cagtcagccc tgaactcaag tcttacgctt tgggagttct ttttctcctc     1740

cttcgtttgt tgggcttcat ccctccaccc ctcatcttcg gggctggcat cgactccacc     1800

tgcctgttct ggagcacgtt ctgtggggag caaggcgcct gcgtcctcta cgacaatgtg     1860

gtctaccgat acctgtatgt cagcatcgcc atcgcgctca aatccttcgc cttcatcctg     1920

tacaccacca cgtggcagtg cctgaggaaa aactataaac gctacatcaa aaaccacgag     1980

ggcgggctga gcaccagtga gttctttgcc tctactctga ccctagacaa cctggggagg     2040

gaccctgtgc ccgcaaacca gacacatagg acaaagttta tctataacct ggaagaccat     2100

gagtggtgtg aaaacatgga gtccgtttta tag                                  2133


<210>  515
<211>  1659
<212>  DNA
<213>  Homo sapiens;

<400>  515
atggacaata tgtctattac gaatacacca acaagtaatg atgcctgtct gagcattgtg       60

catagtttga tgtgccatag acaaggtgga gagagtgaaa catttgcaaa aagagcaatt      120

gaaagtttgg taaagaagct gaaggagaaa aaagatgaat tggattcttt aataacagct      180

ataactacaa atggagctca tcctagtaaa tgtgttacca tacagagaac attggatggg      240

aggcttcagg tggctggtcg gaaaggattt cctcatgtga tctatgcccg tctctggagg      300

tggcctgatc ttcacaaaaa tgaactaaaa catgttaaat attgtcagta tgcgtttgac      360

ttaaaatgtg atagtgtctg tgtgaatcca tatcactacg aacgagttgt atcacctgga      420

attgatctct caggattaac actgcagagt aatgctccat caagtatgat ggtgaaggat      480

gaatatgtgc atgactttga gggacagcca tcgttgtcca ctgaaggaca ttcaattcaa      540

accatccagc atccaccaag taatcgtgca tcgacagaga catacagcac cccagctctg      600

ttagccccat ctgagtctaa tgctaccagc actgccaact ttcccaacat tcctgtggct      660

tccacaagtc agcctgccag tatactgggg ggcagccata gtgaaggact gttgcagata      720

gcatcagggc ctcagccagg acagcagcag aatggattta ctggtcagcc agctacttac      780

catcataaca gcactaccac ctggactgga agtaggactg caccatacac acctaatttg      840

cctcaccacc aaaacggcca tcttcagcac cacccgccta tgccgcccca tcccggacat      900

tactggcctg ttcacaatga gcttgcattc cagcctccca tttccaatca tcctgctcct      960

gagtattggt gttccattgc ttactttgaa atggatgttc aggtaggaga gacatttaag     1020

gttccttcaa gctgccctat tgttactgtt gatggatacg tggacccttc tggaggagat     1080

cgcttttgtt tgggtcaact ctccaatgtc cacaggacag aagccattga gagagcaagg     1140

ttgcacatag gcaaaggtgt gcagttggaa tgtaaaggtg aaggtgatgt ttgggtcagg     1200

tgccttagtg accacgcggt ctttgtacag agttactact tagacagaga agctgggcgt     1260

gcacctggag atgctgttca taagatctac ccaagtgcat atataaaggt ctttgatttg     1320

cgtcagtgtc atcgacagat gcagcagcag gcggctactg cacaagctgc agcagctgcc     1380

caggcagcag ccgtggcagg aaacatccct ggcccaggat cagtaggtgg aatagctcca     1440

gctatcagtc tgtcagctgc tgctggaatt ggtgttgatg accttcgtcg cttatgcata     1500

ctcaggatga gttttgtgaa aggctgggga ccggattacc caagacagag catcaaagaa     1560

acaccttgct ggattgaaat tcacttacac cgggccctcc agctcctaga cgaagtactt     1620

cataccatgc cgattgcaga cccacaacct ttagactga                            1659


<210>  516
<211>  267
<212>  DNA
<213>  Homo sapiens;

<400>  516
atgtctatta tggaccacag ccccaccacg ggcgtggtca cagtcatcgt catcctcatt       60

gccatcgcgg ccctgggggc cttgatcctg ggctgctggt gctacctgcg gctgcagcgc      120

atcagccagt cagaggacga ggagagcatc gtgggggatg gggagaccaa ggaacccttc      180

ctgctggtgc agtattcggc caagggaccg tgcgtggaga gaaaggccaa gctgatgact      240

cccaacggcc cggaagtcca cggctga                                          267


<210>  517
<211>  2298
<212>  DNA
<213>  Homo sapiens;

<400>  517
atggcaggat ttaagcgagg gtatgatgga aagattgctg gattatatga tctggataaa       60

accttgggtc gaggccattt tgccgtggtt aaacttgcca ggcatgtctt tacgggtgaa      120

aaggtggcag taaaagttat tgacaagaca aaactggaca ctctagctac tggtcatctt      180

ttccaggaag tgagatgcat gaaactagtg cagcatccta acatcgtccg cctttatgaa      240

gttattgaca cccagaccaa actatatctt attctagaac ttggggatgg aggagatatg      300

tttgattata taatgaaaca tgaggagggt cttaatgaag acttggccaa gaagtatttt      360

gctcagatag ttcatgctat atcttattgc cataaactcc atgtggttca cagagactta      420

aaaccagaga atgtagtctt ctttgaaaaa caaggtcttg taaagttgac agactttggg      480

ttcagcaaca aatttcaacc agggaagaag ctcactacaa gctgtggatc tcttgcatat      540

tccgctccag aaattctgct tggtgatgag tatgatgcac ctgcagtaga tatttggagt      600

ctgggagtga tccttttcat gttggtgtgt gggcagccgc cctttcaaga agccaatgac      660

agtgaaacac tgacaatgat catggattgc aaatatacag taccatccca tgtgtctaaa      720

gagtgtaaag acctaatcac acggatgcta cagagagatc ccaagagaag ggcttcttta      780

gaagagattg aaaatcatcc ttggcttcag ggagtggacc cttcaccagc tacaaagtat      840

aacattcccc ttgtgtcata caaaaatctc tcggaagagg agcacaacag catcattcag      900

cgcatggtgc ttggggacat agcggatcga gacgccattg tagaagccct ggaaaccaac      960

aggtataacc atatcacagc cacatacttc ctgctggctg aaaggatcct gagagaaaag     1020

caagagaaag aaatacagac cagatctgca agcccgagca atatcaaggc ccagtttagg     1080

cagtcatggc caaccaaaat tgatgtaccc caggaccttg aggatgacct cacggccact     1140

cctttgtccc acgcgactgt ccctcagtct cctgctcggg ctgctgacag tgtcctcaat     1200

ggccacagga gcaaaggcct gtgtgactca gctaagaaag atgacctccc tgagttggct     1260

ggaccagcac tctctacggt gccacccgca agcttaaaac ccacagccag tgggcggaag     1320

tgtctgttca gggtggaaga agatgaagag gaagatgagg aggacaagaa acccatgtcc     1380

ctctcaacac aagtggtttt gcgccggaag ccatctgtaa ccaaccgcct gacatccagg     1440

aagagtgcgc ccgtcctcaa ccagatcttt gaggaagggg aatctgacga tgagtttgac     1500

atggatgaga atctgcctcc caagttgagc aggttaaaga tgaatatagc ttctccaggt     1560

acagttcaca aacgctacca ccggaggaaa agtcagggcc ggggctccag ctgcagtagt     1620

tcggagacca gtgatgatga ttctgaaagc cggcggcggc tcgataaaga tagcgggttc     1680

acctactcct ggcaccgacg ggatagcagc gaggggcccc ctggcagtga gggggatggc     1740

gggggccaga gcaagccaag caatgccagt ggaggggtgg acaaggccag ccccagtgag     1800

aacaatgctg gtgggggcag tccctccagc ggctcgggtg gcaaccccac caatacatcg     1860

ggtaccacac gccgctgtgc cggccccagc aactccatgc agctggcctc tcgcagtgct     1920

ggggagctcg ttgagagcct caaactcatg agcctctgcc tcggctccca gcttcatggg     1980

agcaccaagt acattattga tccacagaat ggcttgtcat tttccagtgt gaaagtccaa     2040

gagaaatcta cgtggaaaat gtgcattagc tccacaggga atgcagggca ggtccctgca     2100

gtgggcggca taaagttttt ctctgaccac atggcagata ccaccactga attggaacgg     2160

ataaagagca agaacctgaa aaataacgtg ctgcagctac ctctgtgcga aaagaccatc     2220

tctgtgaaca tccagcggaa ccctaaggag gggctgctgt gcgcatccag cccagccagc     2280

tgttgccatg tcatctga                                                   2298


<210>  518
<211>  1587
<212>  DNA
<213>  Homo sapiens;

<400>  518
atggcggacg aggacgggga agggattcat ccctcagccc ctcacaggaa cggaggtggc       60

ggcggcggcg gggggtctgg gctccactgc gccgggaacg gcggcggggg aggcggcggc      120

ccgcgggtcg tgcgcatcgt caagtccgag tccggctacg gcttcaacgt gcggggccaa      180

gtgagcgagg gcgggcaact gcggagcatc aacggggagc tgtacgcgcc gctgcagcat      240

gtgagcgccg tgctgcccgg gggggcggcc gatcgggccg gggtgcgcaa gggggaccgc      300

atcctggagg tgaaccacgt gaatgttgag ggggcgacac acaagcaggt ggtggacctg      360

attcgagcag gcgagaagga attgatcttg acagtgttat ctgtacctcc tcatgaggca      420

gataacctag atcccagtga cgactcgttg ggacaatcat tttatgatta cacagaaaag      480

caagcagtgc ccatatcggt ccccagatac aaacatgtgg agcagaatgg tgagaagttt      540

gtggtatata atgtttacat ggcagggagg cagctgtgtt ctaagcggta ccgggagttt      600

gctatcctac accagaacct gaagagagag tttgccaact ttacatttcc tcgactccca      660

gggaagtggc cattttcatt atcagaacaa caattagatg cccgacgtcg gggattggaa      720

gaatatctag aaaaagtgtg ttcaatacga gtaattggtg agagtgacat catgcaggaa      780

ttcctatcag aatccgatga gaactacaat ggtgtgtccg acgtagagct gagagtagca      840

ttaccagatg gaacaacggt tacagtcagg gttaaaaaga acagtactac agaccaagta      900

tatcaggcta tcgcagcaaa ggttggcatg gacagtacga cagtgaatta ctttgcctta      960

tttgaagtga tcagtcactc ctttgtacgt aaattggcac ctaatgagtt tcctcacaaa     1020

ctctacattc agaattatac atcagctgtg ccaggcacct gcttgaccat tcgaaagtgg     1080

ctttttacaa cagaagaaga aattctctta aatgacaatg accttgctgt tacctacttc     1140

tttcatcagg cagtcgatga tgtgaagaaa ggttacatca aagcagaaga aaagtcctat     1200

caattacaga agctatacga acaaagaaaa atggtcatgt acctcaacat gctaaggact     1260

tgtgagggct acaatgaaat catctttccc cactgtgcct gtgactccag gaggaagggg     1320

cacgttatca cagccatcag catcacgcac tttaaactgc atgcctgcac tgaagaagga     1380

cagctggaga accaggtaat tgcatttgaa tgggatgaga tgcagcgatg ggacacagat     1440

gaagaaggga tggccttctg tttcgaatat gcacgaggag agaagaagcc ccgatgggtt     1500

aaaatcttca cgccatattt caattacatg catgagtgct tcgagagggt gttctgcgag     1560

ctcaagtgga gaaaagagga atattag                                         1587


<210>  519
<211>  1653
<212>  DNA
<213>  Homo sapiens;

<400>  519
atggtgggtg aagagaagat gtctctaaga aaccggctgt caaagtccag ggaaaatcct       60

gaggaagatg aagaccagag aaaccctgca aaggagtccc tagagacacc tagtaatggt      120

cgaattgaca taaaacagtt gatagcaaag aagataaagt tgacagcaga ggcagaggaa      180

ttgaagccat tttttatgaa ggaagttggc agtcactttg atgattttgt gaccaatctc      240

attgaaaagt cagcatcatt agataatggt gggtgcgctc tcacaacctt ttctgttctt      300

gaaggagaga aaaacaacca tagagcgaag gatttgagag cacctccaga acaaggaaag      360

atttttattg caaggcgctc tctcttagat gaactgcttg aagtggacca catcagaaca      420

atatatcaca tgtttattgc cctcctcatt ctctttatcc tcagcacact tgtagtagat      480

tacattgatg aaggaaggct ggtgcttgag ttcagcctcc tgtcttatgc ttttggcaaa      540

tttcctaccg ttgtttggac ctggtggatc atgttcctgt ctacattttc agttccctat      600

tttctgtttc aacattgggc cactggctat agcaagagtt ctcatccgct gatccgttct      660

ctcttccatg gctttctttt catgatcttc cagattggag ttctaggttt tggaccaaca      720

tatgttgtgt tagcatatac actgccacca gcttcccggt tcatcattat attcgagcag      780

attcgttttg taatgaaggc ccactcattt gtcagagaga acgtgcctcg ggtactaaat      840

tcagctaagg agaaatcaag cactgttcca atacctacag tcaaccagta tttgtacttc      900

ttatttgctc ctacccttat ctaccgtgac agctatccca ggaatcccac tgtaagatgg      960

ggttatgtcg ctatgaagtt tgcacaggtc tttggttgct ttttctatgt gtactacatc     1020

tttgaaaggc tttgtgcccc cttgtttcgg aatatcaaac aggagccctt cagcgctcgt     1080

gttctggtcc tatgtgtatt taactccatc ttgccaggtg tgctgattct cttccttact     1140

ttttttgcct ttttgcactg ctggctcaat gcctttgctg agatgttacg ctttggtgac     1200

aggatgttct ataaggattg gtggaactcc acgtcatact ccaactatta tagaacctgg     1260

aatgtggtgg tccatgactg gctatattac tatgcttaca aggactttct ctggtttttc     1320

tccaagagat tcaaatctgc tgccatgtta gctgtctttg ctgtatctgc tgtagtacac     1380

gaatatgcct tggctgtttg cttgagcttt ttctatcccg tgctcttcgt gctcttcatg     1440

ttctttggaa tggctttcaa cttcattgtc aatgatagtc ggaaaaagcc gatttggaat     1500

gttctgatgt ggacttctct tttcttgggc aatggagtct tactctgctt ttattctcaa     1560

gaatggtatg cacgtcagca ctgtcctctg aaaaatccca catttttgga ttatgtccgg     1620

ccacgttcct ggacttgtcg ttacgtgttt tag                                  1653


<210>  520
<211>  6645
<212>  DNA
<213>  Homo sapiens;

<400>  520
atggcgacac ggagcagcag gagggagtcg cgactcccgt tcctattcac cctggtcgca       60

ctgctgccgc ccggagctct ctgcgaagtc tggacgcaga ggctgcacgg cggcagcgcg      120

cccttgcccc aggaccgggg cttcctcgtg gtgcagggcg acccgcgcga gctgcggctg      180

tgggcgcgcg gggatgccag gggggcgagc cgcgcggacg agaagccgct ccggaggaaa      240

cggagcgctg ccctgcagcc cgagcccatc aaggtgtacg gacaggttag tctgaatgat      300

tcccacaatc agatggtggt gcactgggct ggagagaaaa gcaacgtgat cgtggccttg      360

gcccgagata gcctggcatt ggcgaggccc aagagcagtg atgtgtacgt gtcttacgac      420

tatggaaaat cattcaagaa aatttcagac aagttaaact ttggcttggg aaataggagt      480

gaagctgtta tcgcccagtt ctaccacagc cctgcggaca acaagcggta catctttgca      540

gacgcttatg cccagtacct ctggatcacg tttgacttct gcaacactct tcaaggcttt      600

tccatcccat ttcgggcagc tgatctcctc ctacacagta aggcctccaa ccttctcttg      660

ggctttgaca ggtcccaccc caacaagcag ctgtggaagt cagatgactt tggccagacc      720

tggatcatga ttcaggaaca tgtcaagtcc ttttcttggg gaattgatcc ctatgacaaa      780

ccaaatacca tctacattga acgacatgaa ccctctggct actccactgt cttccgaagt      840

acagatttct tccagtcccg ggaaaaccag gaagtgatcc ttgaggaagt gagagatttt      900

cagcttcggg acaagtacat gtttgctaca aaggtggtgc atctcttggg cagtgaacag      960

cagtcttctg tccagctctg ggtctccttt ggccggaagc ccatgagagc agcccagttt     1020

gtcacaagac atcctattaa tgaatattac atcgcagatg cctccgagga ccaggtgttt     1080

gtgtgtgtca gccacagtaa caaccgcacc aatttataca tctcagaggc agaggggctg     1140

aagttctccc tgtccttgga gaacgtgctc tattacagcc caggaggggc cggcagtgac     1200

accttggtga ggtattttgc aaatgaacca tttgctgact tccaccgagt ggaaggattg     1260

caaggagtct acattgctac tctgattaat ggttctatga atgaggagaa catgagatcg     1320

gtcatcacct ttgacaaagg gggaacctgg gagtttcttc aggctccagc cttcacggga     1380

tatggagaga aaatcaattg tgagctttcc cagggctgtt cccttcatct ggctcagcgc     1440

ctcagtcagc tcctcaacct ccagctccgg agaatgccca tcctgtccaa ggagtcggct     1500

ccaggcctca tcatcgccac tggctcagtg ggaaagaact tggctagcaa gacaaacgtg     1560

tacatctcta gcagtgctgg agccaggtgg cgagaggcac ttcctggacc tcactactac     1620

acatggggag accacggcgg aatcatcacg gccattgccc agggcatgga aaccaacgag     1680

ctaaaataca gtaccaatga aggggagacc tggaaaacat tcatcttctc tgagaagcca     1740

gtgtttgtgt atggcctcct cacagaacct ggggagaaga gcactgtctt caccatcttt     1800

ggctcgaaca aagagaatgt ccacagctgg ctgatcctcc aggtcaatgc cacggatgcc     1860

ttgggagttc cctgcacaga gaatgactac aagctgtggt caccatctga tgagcggggg     1920

aatgagtgtt tgctgggaca caagactgtt ttcaaacggc ggacccccca tgccacatgc     1980

ttcaatggag aggactttga caggccggtg gtcgtgtcca actgctcctg cacccgggag     2040

gactatgagt gtgacttcgg tttcaagatg agtgaagatt tgtcattaga ggtttgtgtt     2100

ccagatccgg aattttctgg aaagtcatac tcccctcctg tgccttgccc tgtgggttct     2160

acttacagga gaacgagagg ctaccggaag atttctgggg acacttgtag cggaggagat     2220

gttgaagcgc gactggaagg agagctggtc ccctgtcccc tggcagaaga gaacgagttc     2280

attctgtatg ctgtgaggaa atccatctac cgctatgacc tggcctcggg agccaccgag     2340

cagttgcctc tcaccgggct acgggcagca gtggccctgg actttgacta tgagcacaac     2400

tgtttgtatt ggtccgacct ggccttggac gtcatccagc gcctctgttt gaatggaagc     2460

acagggcaag aggtgatcat caattctggc ctggagacag tagaagcttt ggcttttgaa     2520

cccctcagcc agctgcttta ctgggtagat gcaggcttca aaaagattga ggtagctaat     2580

ccagatggcg acttccgact cacaatcgtc aattcctctg tgcttgatcg tcccagggct     2640

ctggtcctcg tgccccaaga gggggtgatg ttctggacag actggggaga cctgaagcct     2700

gggatttatc ggagcaatat ggatggttct gctgcctatc acctggtgtc tgaggatgtg     2760

aagtggccca atggcatctc tgtggacgac cagtggattt actggacgga tgcctacctg     2820

gagtgcatag agcggatcac gttcagtggc cagcagcgct ctgtcattct ggacaacctc     2880

ccgcacccct atgccattgc tgtctttaag aatgaaatct actgggatga ctggtcacag     2940

ctcagcatat tccgagcttc caaatacagt gggtcccaga tggagattct ggcaaaccag     3000

ctcacggggc tcatggacat gaagattttc tacaagggga agaacactgg aagcaatgcc     3060

tgtgtgccca ggccatgcag cctgctgtgc ctgcccaagg ccaacaacag tagaagctgc     3120

aggtgtccag aggatgtgtc cagcagtgtg cttccatcag gggacctgat gtgtgactgc     3180

cctcagggct atcagctcaa gaacaatacc tgtgtcaaac aagagaacac ctgtcttcgc     3240

aaccagtatc gctgcagcaa cgggaactgt atcaacagca tttggtggtg tgactttgac     3300

aacgactgtg gagacatgag cgatgagaga aactgcccta ccaccatctg tgacctggac     3360

acccagtttc gttgccagga gtctgggact tgtatcccac tgtcctataa atgtgacctt     3420

gaggatgact gtggagacaa cagtgatgaa agtcattgtg aaatgcacca gtgccggagt     3480

gacgagtaca actgcagttc cggcatgtgc atccgctcct cctgggtatg tgacggggac     3540

aacgactgca gggactggtc tgatgaagcc aactgtaccg ccatctatca cacctgtgag     3600

gcctccaact tccagtgccg aaacgggcac tgcatccccc agcggtgggc gtgtgacggg     3660

gatacggact gccaggatgg ttccgatgag gatccagtca actgtgagaa gaagtgcaat     3720

ggattccgct gcccaaacgg cacttgcatc ccatccagca aacattgtga tggtctgcgt     3780

gattgctctg atggctccga tgaacagcac tgcgagcccc tctgtacgca cttcatggac     3840

tttgtgtgta agaaccgcca gcagtgcctg ttccactcca tggtctgtga cggaatcatc     3900

cagtgccgcg acgggtccga tgaggatgcg gcgtttgcag gatgctccca agatcctgag     3960

ttccacaagg tatgtgatga gttcggtttc cagtgtcaga atggagtgtg catcagtttg     4020

atttggaagt gcgacgggat ggatgattgc ggcgattatt ctgatgaagc caactgcgaa     4080

aaccccacag aagccccaaa ctgctcccgc tacttccagt ttcggtgtga gaatggccac     4140

tgcatcccca acagatggaa atgtgacagg gagaacgact gtggggactg gtctgatgag     4200

aaggattgtg gagattcaca tattcttccc ttctcgactc ctgggccctc cacgtgtctg     4260

cccaattact accgctgcag cagtgggacc tgcgtgatgg acacctgggt gtgcgacggg     4320

taccgagatt gtgcagatgg ctctgacgag gaagcctgcc ccttgcttgc aaacgtcact     4380

gctgcctcca ctcccaccca acttgggcga tgtgaccgat ttgagttcga atgccaccaa     4440

ccgaagacgt gtattcccaa ctggaagcgc tgtgacggcc accaagattg ccaggatggc     4500

cgggacgagg ccaattgccc cacacacagc accttgactt gcatgagcag ggagttccag     4560

tgcgaggacg gggaggcctg cattgtgctc tcggagcgct gcgacggctt cctggactgc     4620

tcggacgaga gcgatgaaaa ggcctgcagt gatgagttga ctgtgtacaa agtacagaat     4680

cttcagtgga cagctgactt ctctggggat gtgactttga cctggatgag gcccaaaaaa     4740

atgccctctg cttcttgtgt atataatgtc tactacaggg tggttggaga gagcatatgg     4800

aagactctgg agacccacag caataagaca aacactgtat taaaagtctt gaaaccagat     4860

accacgtatc aggttaaagt acaggttcag tgtctcagca aggcacacaa caccaatgac     4920

tttgtgaccc tgaggacccc agagggattg ccagatgccc ctcgaaatct ccagctgtca     4980

ctccccaggg aagcagaagg tgtgattgta ggccactggg ctcctcccat ccacacccat     5040

ggcctcatcc gtgagtacat tgtagaatac agcaggagtg gttccaagat gtgggcctcc     5100

cagagggctg ctagtaactt tacagaaatc aagaacttat tggtcaacac tctatacacc     5160

gtcagagtgg ctgcggtgac tagtcgtgga ataggaaact ggagcgattc taaatccatt     5220

accaccataa aaggaaaagt gatcccacca ccagatatcc acattgacag ctatggtgaa     5280

aattatctaa gcttcaccct gaccatggag agtgatatca aggtgaatgg ctatgtggtg     5340

aaccttttct gggcatttga cacccacaag caagagagga gaactttgaa cttccgagga     5400

agcatattgt cacacaaagt tggcaatctg acagctcata catcctatga gatttctgcc     5460

tgggccaaga ctgacttggg ggatagccct ctggcatttg agcatgttat gaccagaggg     5520

gttcgcccac ctgcacctag cctcaaggcc aaagccatca accagactgc agtggaatgt     5580

acctggaccg gcccccggaa tgtggtttat ggtattttct atgccacgtc ctttcttgac     5640

ctctatcgca acccgaagag cttgactact tcactccaca acaagacggt cattgtcagt     5700

aaggatgagc agtatttgtt tctggtccgt gtagtggtac cctaccaggg gccatcctct     5760

gactacgttg tagtgaagat gatcccggac agcaggcttc caccccgtca cctgcatgtg     5820

gttcatacgg gcaaaacctc cgtggtcatc aagtgggaat caccgtatga ctctcctgac     5880

caggacttgt tgtatgcagt tgcagtcaaa gatctcataa gaaagactga caggagctac     5940

aaagtaaaat cccgtaacag cactgtggaa tacaccctta acaagttgga gcctggcggg     6000

aaataccaca tcattgtcca actggggaac atgagcaaag attccagcat aaaaattacc     6060

acagtttcat tatcagcacc tgatgcctta aaaatcataa cagaaaatga tcatgttctt     6120

ctgttttgga aaagcctggc tttaaaggaa aagcatttta atgaaagcag gggctatgag     6180

atacacatgt ttgatagtgc catgaatatc acagcttacc ttgggaatac tactgacaat     6240

ttctttaaaa tttccaacct gaagatgggt cataattaca cgttcaccgt ccaagcaaga     6300

tgcctttttg gcaaccagat ctgtggggag cctgccatcc tgctgtacga tgagctgggg     6360

tctggtgcag atgcatctgc aacgcaggct gccagatcta cggatgttgc tgctgtggtg     6420

gtgcccatct tattcctgat actgctgagc ctgggggtgg ggtttgccat cctgtacacg     6480

aagcaccgga ggctgcagag cagcttcacc gccttcgcca acagccacta cagctccagg     6540

ctggggtccg caatcttctc ctctggggat gacctggggg aagatgatga agatgcccct     6600

atgataactg gattttcaga tgacgtcccc atggtgatag cctga                     6645


<210>  521
<211>  3999
<212>  DNA
<213>  Homo sapiens;

<400>  521
atgcagcagg cgccgcagcc ttacgagttc ttcagcgagg agaacagtcc gaaatggcgg       60

ggactgttgg tctcggccct gcggaaggtt caggaacaag tgcatcccac tctctcagct      120

aatgaagagt ctctctatta tattgaagag ctgatttttc agctgcttaa taaattatgc      180

atggcccagc caaggactgt tcaagatgta gaggagcgag ttcagaagac ctttcctcac      240

ccaattgata aatgggccat tgctgatgca caatctgcta tagaaaaacg aaaacgaaga      300

aatcctcttt tactgcctgt ggacaaaatc catccttcgt tgaaggaagt attagggtac      360

aaagtggact accatgtatc cctatatatt gtggctgtac tagagtatat ctcagctgat      420

attttaaaat tggctggtaa ttatgttttt aatatccggc attatgaaat atctcagcag      480

gacattaaag tgtcaatgtg tgcggataag gttttgatgg acatgtttga tcaggatgac      540

ataggtttgg tttctctctg tgaagatgaa cctagttctt ctggtgaatt aaactactat      600

gatcttgtca gaactgaaat cgcagaagaa agacagtatc tacgggaatt aaatatgatc      660

ataaaagtgt ttcgagaagc ctttctttct gatagaaagc tgtttaaacc ttctgatatc      720

gaaaagattt ttagtaacat ttcagatata catgaattga ctgtgaaact tttaggtttg      780

attgaagaca cagttgaaat gactgatgaa agcagtcctc atcccttagc tggcagctgt      840

tttgaagatt tggcagaaga gcaagcattt gatccttatg aaacattatc acaggacatt      900

ctttcaccag agtttcatga acatttcaat aaattgatgg ccagacctgc agttgctcta      960

cactttcagt ccattgctga tggttttaaa gaggcagttc gttatgtcct tccacgtctt     1020

atgctggtgc cagtgtatca ctgttggcac tactttgagt tactaaagca attgaaagca     1080

tgtagtgaag aacaagaaga cagagaatgt ttgaaccaag ctattactgc tctcatgaat     1140

ctccaaggta gcatggaccg aatttacaag cagtattcac ctagacgtcg acctggagat     1200

cctgtttgcc ctttttatag tcaccaatta agaagcaaac acctggctat caaaaaaatg     1260

aatgaaattc agaaaaatat cgatggatgg gaaggcaaag atattggaca gtgttgtaat     1320

gaattcatta tggagggacc attgacaaga atcggtgcca aacatgaacg gcatattttt     1380

ctgtttgatg gcttaatgat cagttgtaaa cctaatcatg gccagactcg gcttccaggt     1440

tacagtagtg cagaatacag gttaaaagaa aaatttgtca tgaggaaaat acaaatttgt     1500

gataaagaag atacttgtga gcacaagcat gcatttgaat tagtatccaa agatgagaac     1560

agcataatat ttgctgctaa gtctgctgaa gaaaaaaaca actggatggc agcccttatt     1620

tctcttcatt atcgtagtac tctagatcga atgttagatt cagtattatt gaaagaagaa     1680

aatgagcaac cactgagatt accaagtcct gaagtatatc gttttgtagt aaaagactct     1740

gaggaaaaca ttgtttttga agacaacttg caaagtagaa gtggcatccc cattattaaa     1800

ggaggaactg tagtgaaatt aattgaaagg ttaacatatc atatgtatgc agatcccaat     1860

tttgttcgta cttttcttac cacatatcgt tcattttgta aaccacagga attgctgagc     1920

ttactgattg aacggtttga aattccagag ccagaaccta ctgacgcaga caaattggca     1980

atagagaaag gcgagcagcc aatcagtgca gaccttaaaa gatttcgcaa ggaatatgtc     2040

caaccagtac aacttaggat cttaaatgta tttcggcatt gggttgaaca tcatttttat     2100

gactttgaaa gagacttgga attgcttgaa agactagaat ccttcatttc aagtgtaaga     2160

gggaaagcta tgaaaaaatg ggtagagtca attgctaaga tcatcaggag gaagaagcaa     2220

gctcaggcaa acggagtaag ccataatatt acctttgaaa gtccacctcc accaattgaa     2280

tggcatatca gcaaaccagg acagtttgaa acatttgatc tcatgacact tcatccaata     2340

gaaattgcac gtcagctgac acttttggag tctgatcttt acaggaaagt tcaaccgtct     2400

gaacttgtag ggagtgtgtg gaccaaagaa gataaagaaa taaattctcc aaatttatta     2460

aaaatgattc gccataccac aaatctcacc ctctggtttg aaaaatgcat tgtggaagca     2520

gaaaattttg aagaacgggt ggcagtacta agtagaatta tagaaattct gcaagttttt     2580

caagatttga ataatttcaa tggcgtattg gagatagtca gtgcagtaaa ttcagtgtca     2640

gtatacagac tagaccatac ctttgaggca ctgcaggaaa ggaaaaggaa aattttggac     2700

gaagctgtgg aattaagtca agatcacttt aaaaaatacc tagtaaaact taagtcaatc     2760

aatccacctt gtgtgccttt ttttggaata tatttaacaa atattctgaa gaccgaagaa     2820

gggaataatg attttttaaa aaagaaaggg aaagatttaa tcaatttcag taagaggagg     2880

aaagtagctg aaattactgg agaaattcag cagtatcaga atcagcctta ctgtttacgg     2940

atagaaccag atatgaggag attctttgaa aaccttaacc ccatgggaag tgcatctgaa     3000

aaagagttta cagattattt gttcaacaag tcactagaaa ttgaacctcg aaactgcaaa     3060

cagccacctc gatttcctag gaaatcaact ttttccttaa aatctcctgg aataaggcct     3120

aacacaggcc gacatggctc tacctcaggt actttacgag gtcacccaac accattagaa     3180

agagaaccat gtaaaataag ctttagtcgg attgctgaaa ctgagctgga atcaacagtg     3240

tcagcaccaa cctctccaaa tacaccatct actccaccag tatctgcttc ttcagacctt     3300

agtgtatttt tagatgtgga tctcaacagc tcctgtggca gcaatagcat ctttgctcca     3360

gtgcttttgc cacattcaaa gtctttcttt agttcatgtg gtagtttaca taaactaagt     3420

gaagagcccc tgattcctcc tcctcttcct cctcgaaaaa agtttgatca tgatgcttca     3480

aattccaagg gaaatatgaa atctgatgat gatcctcctg ctattccacc gagacagcct     3540

cctcctccaa aggtaaaacc cagagttcct gttcctactg gtgcatttga tgggcctctg     3600

catagtccac ctccgccacc accaagagat cctcttcctg atacccctcc accagttccc     3660

cttcggcctc cagaacactt tataaactgt ccatttaatc ttcagccacc tccactgggg     3720

catcttcaca gagattcaga ctggctcaga gacattagta cgtgtccaaa ttcgccaagc     3780

actcctccta gcacaccctc tccaagggta ccgcgtcgat gctatgtgct cagttctagt     3840

cagaataatc ttgctcatcc tccagctccc cctgttccac caaggcagaa ttcaagccct     3900

catctgccaa aactgccacc aaagacttac aaacgggagc tttcgcaccc cccattgtac     3960

agactgcctt tgctagaaaa tgcagaaact ccccaatga                            3999


<210>  522
<211>  2346
<212>  DNA
<213>  Homo sapiens;

<400>  522
atgaccgctc ccgaaaagcc cgtgaaacaa gaggaaatgg ctgccttgga cgtggatagc       60

ggcggcggcg gtggcggcgg cggcggccac ggcgagtatc tgcagcagca gcaacagcac      120

ggaaacggtg cggtggcggc ggcagcggcg gcccaggaca ctcagccgtc accgctcgct      180

ctgctggccg ctacctgcag caagataggg ccgccatcgc cgggcgacga cgaggaggag      240

gcggccgccg cagccggggc ccccgccgcc gccggagcga caggtgattt ggcttctgca      300

cagttaggag gagcaccaaa ccgatgggag gttttgtcag ccacacctac aactataaaa      360

gatgaagctg gtaatctagt ccagattcca agtgctgcta cttcaagtgg gcagtatgtt      420

cttccccttc agaatttgca gaatcaacaa atattttccg ttgcaccagg atcagattca      480

tcaaatggta cagtgtccag tgttcaatat caagtgatac cacagatcca gtcagcagat      540

ggtcagcagg ttcaaattgg tttcacaggc tcttcagata atgggggtat aaatcaagaa      600

agcagtcaaa ttcagatcat tcctggctct aatcaaacct tacttgcctc tggaacacct      660

tctgctaaca tccagaatct cataccacag actggtcaag tccaggttca gggagttgca      720

attggtggtt catcttttcc tggtcaaacc caagtagttg ctaatgtgcc tcttggtctg      780

ccaggaaata ttacgtttgt accaatcaat agtgtcgatc tagattcttt gggactctcg      840

ggcagttctc agacaatgac tgcaggcatt aatgccgacg gacatttgat aaacacagga      900

caagctatgg atagttcaga caattcagaa aggactggtg agcgggtttc tcctgatatt      960

aatgaaacta atactgatac agatttattt gtgccaacat cctcttcatc acagttgcct     1020

gttacgatag atagtacagg tatattacaa caaaacacaa atagcttgac tacatctagt     1080

gggcaggttc attcttcaga tcttcaggga aattatatcc agtcgcctgt ttctgaagag     1140

acacaggcac agaatattca ggtttctaca gcacagcctg ttgtacagca tctacaactt     1200

caagagtctc agcagccaac cagtcaagcc caaattgtgc aaggtattac accacagaca     1260

atccatggtg tgcaagccag tggtcaaaat atatcacaac aggctttgca aaatcttcag     1320

ttgcagctga atcctggaac ctttttaatt caggcacaga cagtgacccc ttctggacag     1380

gtaacttggc aaacgtttca agtacaaggg gtccagaact tgcagaattt gcaaatacag     1440

aatactgctg cccaacaaat aactttgacg cctgttcaaa ccctcacact tggtcaagtt     1500

gcggcaggtg gagccttcac ttcaactcca gttagtctaa gcactggtca gttgccaaat     1560

ctacaaacag ttacagtgaa ctctatagat tctgctggta tacagctaca tccaggagag     1620

aatgctgaca gtcctgcaga tattaggatc aaggaagaag aacctgatcc tgaagagtgg     1680

cagctcagtg gtgattctac cttgaatacc aatgacctaa cacacttaag agtacaggtg     1740

gtagatgaag aaggggacca acaacatcaa gaaggaaaaa gacttcggag ggtagcttgc     1800

acctgtccca actgtaaaga aggtggtgga agaggtacca atcttgggaa aaagaagcaa     1860

cacatttgtc atataccagg atgtggtaaa gtctatggga agacctcaca tctgagagct     1920

catctgcgtt ggcattctgg agaacgccct tttgtttgta actggatgta ctgtggtaaa     1980

agatttactc gaagtgatga attacagagg cacagaagaa cacatacagg tgagaagaaa     2040

tttgtttgtc cagaatgttc aaaacgcttt atgagaagtg accaccttgc caaacatatt     2100

aaaacacacc agaataaaaa aggtattcac tctagcagta cagtgctggc atctgtggaa     2160

gctgcgcgag atgatacttt gattactgca ggaggaacaa cgcttatcct tgcaaatatt     2220

caacaaggtt ctgtttcagg gataggaact gttaatactt ccgccaccag caatcaagat     2280

atccttacca acactgaaat acctttacag cttgtcacag tttctggaaa tgagacaatg     2340

gagtaa                                                                2346


<210>  523
<211>  1086
<212>  DNA
<213>  Homo sapiens;

<400>  523
atgtacggca aaggcaagag taacagcagc gccgtcccgt ccgacagcca ggcccgggag       60

aagttagcac tctacgtata tgaatatctg ctccatgtag gagctcagaa atcagctcaa      120

acatttttat cagagataag atgggaaaaa aacatcacat tgggggaacc accaggattc      180

ttacattctt ggtggtgtgt attttgggat ctctactgtg cagctccaga gagacgtgaa      240

acatgtgaac actcaagtga agcaaaagcc ttccatgatt acagtgctgc agcagctccc      300

agtccagtgc taggaaacat tcccccagga gatggcatgc cagtaggtcc tgtaccacca      360

gggttctttc agccttttat gtcacctcgg taccctggag gtccaaggcc cccattgagg      420

atacctaatc aggcacttgg aggtgtccca ggaagtcagc cattactccc cagtggaatg      480

gatccaactc gacaacaagg acatccaaat atgggtgggc caatgcagag aatgactcct      540

ccaagaggaa tggtgccctt aggaccacag aactatggag gtgcaatgag acccccactg      600

aatgctttag gtggccctgg aatgcctgga atgaacatgg gtccaggtgg tggtagacct      660

tggccaaacc caacaaatgc caattcaata ccatactcct cagcatctcc tgggaattat      720

gtaggtcctc caggaggtgg agggccacca ggaacaccca tcatgcctag tccagcagat      780

tcaaccaact ctggtgataa catgtatact ttaatgaatg cagtacctcc tggacctaac      840

agacctaatt ttccaatggg tcctgggtca gatggtccca tgggtggatt aggaggaatg      900

gagtcacatc acatgaatgg ctctttaggc tcaggagata tggacagtat ttccaagaat      960

tctcccaata atatgagcct gagtaatcaa ccgggcactc caagggatga tggcgaaatg     1020

gggggaaatt tcttaaatcc ttttcagagt gagagttact cccctagcat gacaatgagc     1080

gtgtga                                                                1086


<210>  524
<211>  3771
<212>  DNA
<213>  Homo sapiens;

<400>  524
atggaccggc ccctgtcgtc gtcggcggag gcggaggagg aactggagtg gcaagtggcg       60

agtcgcagga ggaaggcctg ggccaagtgc cgcagctcct ggcaagcgtc ggagacggag      120

gatctgtcca cagaagcgac gacgcaggac gaggaggagg acgaggagga ggacctcccc      180

ggcgcgcagc tgccggcagc ggggggaaga ggaaacgtgc ccaacgagaa gatcgcgata      240

tggctcaagg actgccgtac acctttggga gcctcactgg atgaacaaag cagtagtaca      300

ctcaagggtg tgcttgtgag aaatggagga agttttgaag atgatttgtc attgggagct      360

gaagccaacc acctccatga aagtgatgct caaattgaaa actgcaataa tatcttggcc      420

aaagagagaa gattacagtt tcatcagaaa gggagaagta tgaattccac tggatctggg      480

aaaagtagtg ggacagtttc aagtgtttca gaattgttgg aactttatga ggaagatcct      540

gaagaaattc tttataatct tggatttgga cgtgatgaac cagatattgc ttctaaaatt      600

ccttccagat tttttaattc atcatccttt gccaaaggga tagatattaa agtatttttg      660

agtgctcaga tgcaacggat ggaagtagaa aacccaaatt atgctttaac aagccgtttt      720

cgtcaaattg aagtgcttac tactgtggcc aatgcgtttt cttctttata ttctcaagtc      780

tccgggacgc ccctgcagag aattggaagt atgtcctcag tgacctctaa caaggagaca      840

gacccacctc cacctttaac tcgaagtaac actgcaaatc gtttaatgaa aacactctca      900

aaactgaatt tatgtgttga taaaacagag aaaggagaaa gtagtagtcc ttctccatca      960

gctgaaaaag gaaagattct aaatgtttca gtgattgaag aaagtggcaa taaaaacgat     1020

caaaagtctc aaaaaattat gaagaagaaa gagtcatctt ctatgttggc tacagttaaa     1080

gaagaagtct ctggtagttc agcagctgtt acggagaatg ctgatagtga tagaatttct     1140

gatgaagcaa atagtaattt taaccaagga actgaaaatg aacaaagtaa agaaactcaa     1200

agtcatgaga gtaaactggg tgaggaatct ggtattgtag aatccaaatt agatagtgat     1260

ttcaacatat ccagccacag tgagctggaa aatagcagtg agctgaaaag tgtccatata     1320

tccacacctg aaaaagagcc ttgtgcacca ctgacaatac catccataag aaatataatg     1380

acacagcaga aggactcctt cgaaatggaa gaggttcaaa gtacggaggg agaagctcct     1440

catgttccag ccacttacca gctaggtctt acgaagtcga aaagagatca tctgttacgt     1500

actgcaagtc agcattccga tagcagtggt tttgctgaag attctacaga ctgcctatcc     1560

cttaatcatc ttcaggttca ggagtccttg caggctatgg ggagtagtgc tgatagttgt     1620

gacagtgaga caacagttac gtcacttggt gaagaccttg ccacaccaac agcacaagac     1680

cagccttatt ttaatgaatc agaggaggag tctcttgtcc ctcttcagaa gggactagag     1740

aaggcagcag cagttgcaga caaaagaaaa tcaggtagcc aggatttccc tcagtgcaac     1800

accattgaga atacaggaac taaacagtcc acctgtagtc caggggatca tatcattgaa     1860

attactgaag tggaagagga tttgtttcca gcagagacag tagagctact gagggaagca     1920

agtgctgaaa gtgatgtggg taaaagcagt gaaagtgaat ttactcagta taccacacac     1980

catattctga aatcattggc ttctattgaa gctaaatgca gtgatatgag ctctgaaaat     2040

acaactgggc ctccctcttc catggacaga gttaatacag ctttgcaaag agctcaaatg     2100

aaggtttgca gtctgtctaa tcaaaggatg gggcgtagcc tgctaaaatc aaaagatttg     2160

ttaaaacaaa ggtacttatt tgcaaaagct ggctatcctc taagaaggtc tcagtcttta     2220

ccaaccacct tattgagccc agtaagggtt gtgtcctctg tcaatgttcg attatctcca     2280

ggaaaagaga ccagatgcag cccaccttcc ttcacctata agtacacacc tgaagaggag     2340

caggaattgg aaaagcgggt gatggaacat gatggtcagt ctttagttaa atcgaccatt     2400

ttcatctctc catcatctgt gaagaaagaa gaagcccccc agagtgaggc gccgcgggtg     2460

gaggaatgcc atcatggaag gactcctacc tgttcacggc ttgctccacc accaatgtct     2520

cagtctacct gttcccttca ttccatccac tctgagtggc aagaaaggcc cctgtgtgag     2580

cacacaagaa ctctgagcac tcacagtgtt cccaacatat caggggctac ttgtagtgcc     2640

ttcgcttccc ctttcgggtg tccttactca catagacatg ccacctaccc ttaccgagtg     2700

tgctctgtga atcctccttc agccatagaa atgcagttgc gaagagtatt acatgatatt     2760

agaaactcac tgcagaatct ttcacagtac cctatgatga gaggacctga tcctgctgct     2820

gctccatata gtactcagaa atcatctgtt ctacctcttt atgaaaatac ttttcaggag     2880

ctccaggtaa tgaggcggag cctgaatttg tttagaacac aaatgatgga tttagaattg     2940

gcaatgctgc gtcagcaaac catggtttat catcatatga ctgaggagga gaggtttgaa     3000

gttgatcagc tccagggttt gagaaattca gtccgaatgg aacttcagga cctggaactg     3060

cagctggagg agcgcctgct gggcctggag gagcagcttc gtgctgtgcg catgccttca     3120

cccttccgct cctccgcact catgggaatg tgtggcagta gaagcgctga taacttgtca     3180

tgcccttctc cattgaatgt aatggaacca gtcactgaac tgatgcagga gcagtcatac     3240

ctgaagtctg aattgggcct gggacttgga gaaatgggat ttgaaattcc tcctggagaa     3300

agctcagaat ctgttttttc ccaagcaaca tcagaatcat cttctgtatg ttctggtccc     3360

tctcatgcta acagaagaac tggagtacct tctactgcct cagtgggcaa atccaaaacc     3420

ccattagtgg caaggaagaa agtgttccga gcatcggtgg ctctaacgcc aacagctcct     3480

tctagaacag gctctgtgca gacacctcca gatttggaaa gttctgagga agttgatgca     3540

gctgaaggag ccccagaagt tgtaggacct aaatctgaag tggaagaagg gcatggaaaa     3600

ctcccatcaa tgccagctgc tgaggaaatg cataaaaatg tggagcaaga tgagttgcag     3660

caagtcatac gggaggttgg catggatcct attagctgtg taatactgga attatcaatg     3720

atatgcactg gtggaggtgt tatttgtgct ttagaagata cttgctgttg a              3771


<210>  525
<211>  1110
<212>  DNA
<213>  Homo sapiens;

<400>  525
atggaccccc gcaaagtgaa cgagcttcgg gcctttgtga aaatgtgtaa gcaggatccg       60

agcgttctgc acaccgagga aatgcgcttc ctgagggagt gggtggagag catgggtggt      120

aaagtaccac ctgctactca gaaagctaaa tcagaagaaa ataccaagga agaaaaacct      180

gatagtaaga aggtggagga agacttaaag gcagacgaac catcaagtga ggaaagtgat      240

ctagaaattg ataaagaagg tgtgattgaa ccagacactg atgctcctca agaaatggga      300

gatgaaaatg cggagataac ggaggagatg atggatcagg caaatgataa aaaagtggct      360

gctattgaag ccctaaatga tggtgaactc cagaaagcca ttgacttatt cacagatgcc      420

atcaagctga atcctcgctt ggccattttg tatgccaaga gggccagtgt cttcgtcaaa      480

ttacagaagc caaatgctgc catccgagac tgtgacagag ccattgaaat aaatcctgat      540

tcagctcagc cttacaagtg gcgggggaaa gcacacagac ttctaggcca ctgggaagaa      600

gcagcccatg atcttgccct tgcctgtaaa ttggattatg atgaagatgc tagtgcaatg      660

ctgaaagaag ttcaacctag ggcacagaaa attgcagaac atcggagaaa gtatgagcga      720

aaacgtgaag agcgagagat caaagaaaga atagaacgag ttaagaaggc tcgagaagag      780

catgagagag cccagaggga ggaagaagcc agacgacagt caggagctca gtatggctct      840

tttccaggtg gctttcctgg gggaatgcct ggtaattttc ccggaggaat gcctggaatg      900

ggagggggca tgcctggaat ggctggaatg cctggactca atgaaattct tagtgatcca      960

gaggttcttg cagccatgca ggatccagaa gttatggtgg ctttccagga tgtggctcag     1020

aacccagcaa atatgtcaaa ataccagagc aacccaaagg ttatgaatct catcagtaaa     1080

ttgtcagcca aatttggagg tcaagcgtaa                                      1110


<210>  526
<211>  1023
<212>  DNA
<213>  Homo sapiens;

<400>  526
atggtgaccc tgcggaagag gaccctgaaa gtgctcacct tcctcgtgct cttcatcttc       60

ctcacctcct tcttcctgaa ctactcccac accatggtgg ccaccacctg gttccccaag      120

cagatggtcc tggagctctc cgagaacctg aagagactga tcaagcacag gccttgcacc      180

tgcacccact gcatcgggca gcgcaagctc tcggcctggt tcgatgagag gttcaaccag      240

accatgcagc cgctgctgac cgcccagaac gcgctcttgg aggacgacac ctaccgatgg      300

tggctgaggc tccagcggga gaagaagccc aataacttga atgacaccat caaggagctg      360

ttcagagtgg tgcctgggaa tgtggaccct atgctggaga agaggtcggt gggctgccgg      420

cgctgcgccg ttgtgggcaa ctcgggcaac ctgagggagt cttcttatgg gcctgagata      480

gacagtcacg actttgtcct caggatgaac aaggcgccca cggcagggtt tgaagctgat      540

gttgggacca agaccaccca ccatctggtg taccctgaga gcttccggga gctgggagat      600

aatgtcagca tgatcctggt gcccttcaag accatcgact tggagtgggt ggtgagcgcc      660

atcaccacgg gcaccatttc ccacacctac atcccggttc ctgcaaagat cagagtgaaa      720

caggataaga tcctgatcta ccacccagcc ttcatcaagt atgtctttga caactggctg      780

caagggcacg ggcgataccc atctaccggc atcctctcgg tcatcttctc aatgcatgtc      840

tgcgatgagg tggacttgta cggcttcggg gcagacagca aagggaactg gcaccactac      900

tgggagaaca acccatccgc gggggctttt cgcaagacgg gggtgcacga tgcagacttt      960

gagtctaacg tgacggccac cttggcctcc atcaataaaa tccggatctt caaggggaga     1020

tga                                                                   1023


<210>  527
<211>  1578
<212>  DNA
<213>  Homo sapiens;

<400>  527
atgcctttgt tcaccgccaa ccccttcgag caagacgtgg aaaaagccac gaatgagtac       60

aacactacag aagattggag tcttattatg gacatatgtg acaaagttgg aagtactcct      120

aatggagcga aagattgcct aaaagccata atgaaaaggg taaatcataa ggttccacat      180

gttgctctgc aagcactaac tcttcttggg gcttgtgtgg caaactgtgg aaagatattt      240

catttagaag tatgttcccg tgattttgca acagaagtac gtgctgtgat taaaaataag      300

gcacatccta aagtatgtga aaaactgaaa tctttaatgg tggagtggtc agaagaattt      360

cagaaggacc ctcagtttag tctgatatct gcaactatta aatctatgaa agaagaagga      420

attacttttc ctccagcagg ttctcagact gtctcagctg ctgccaagaa tggtacgtca      480

tcgaacaaaa acaaagagga tgaagacata gctaaagcta ttgaattatc gctgcaagaa      540

cagaaacagc aacacacaga aacaaaatcc ttatatccat cttcagaaat tcagttaaat      600

aataaggttg cacggaaagt gagagcttta tatgattttg aagctgttga ggacaatgaa      660

ctcaccttta aacatggtga aataattatt gttttggatg acagtgatgc caattggtgg      720

aaaggagaaa atcacagagg aataggactt ttcccatcca attttgtaac aactaattta      780

aacatagaga ctgaggcagc ggctgtggac aaattgaatg taattgatga tgatgtggag      840

gaaattaaga aatcagagcc tgagcctgtt tatatagatg aggataagat ggatagagcc      900

ctgcaggtac ttcagagtat agatccaaca gattcaaaac cagactccca agaccttttg      960

gatttagaag atatctgcca acagatgggt ccaatgatag atgaaaaact tgaagaaatt     1020

gataggaagc attcagaatt gtctgaattg aatgttaaag tcctggaagc tctggaacta     1080

tataacaaat tggtgaatga agcaccagtg tactcagtct attcaaagct ccaccctcca     1140

gcacattacc cacctgcatc atctggggtt ccaatgcaga catatccagt tcaatcacat     1200

ggtggaaact atatgggtca gagcattcac caagtaactg ttgcccaaag ctatagccta     1260

ggacccgatc aaattggtcc actgagatct ctgcctccaa atgtgaattc ctcagtgaca     1320

gcacagcctg ctcaaacttc atatttaagc actggacaag acactgtttc caatcctact     1380

tatatgaacc agaactctaa cctacagtca gctactggta caactgctta cacacagcaa     1440

atggggatgt ctgtggatat gtcatcttat cagaacacta cttccaattt gcctcaactg     1500

gcaggctttc cggtgacagt tccagctcat ccagttgcac agcagcacac aaattaccat     1560

cagcagcctc tcctttag                                                   1578


<210>  528
<211>  2253
<212>  DNA
<213>  Homo sapiens;

<400>  528
atgtctcagt ggtacgaact tcagcagctt gactcaaaat tcctggagca ggttcaccag       60

ctttatgatg acagttttcc catggaaatc agacagtacc tggcacagtg gttagaaaag      120

caagactggg agcacgctgc caatgatgtt tcatttgcca ccatccgttt tcatgacctc      180

ctgtcacagc tggatgatca atatagtcgc ttttctttgg agaataactt cttgctacag      240

cataacataa ggaaaagcaa gcgtaatctt caggataatt ttcaggaaga cccaatccag      300

atgtctatga tcatttacag ctgtctgaag gaagaaagga aaattctgga aaacgcccag      360

agatttaatc aggctcagtc ggggaatatt cagagcacag tgatgttaga caaacagaaa      420

gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta tgtgtataga gcatgaaatc      480

aagagcctgg aagatttaca agatgaatat gacttcaaat gcaaaacctt gcagaacaga      540

gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac aagaacagct gttactcaag      600

aagatgtatt taatgcttga caataagaga aaggaagtag ttcacaaaat aatagagttg      660

ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg atgaactagt ggagtggaag      720

cggagacagc agagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag      780

aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg      840

gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg      900

ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa      960

agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag     1020

ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc     1080

aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc     1140

aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg     1200

gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat     1260

gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc     1320

cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac     1380

gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa     1440

cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa     1500

gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac     1560

atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg     1620

aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc     1680

atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc     1740

ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg     1800

ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc     1860

cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct     1920

gctgttactt tccctgacat cattcgcaat tacaaagtca tggctgctga gaatattcct     1980

gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat     2040

tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga     2100

tatatcaaga ctgagttgat ttctgtgtct gaagttcacc cttctagact tcagaccaca     2160

gacaacctgc tccccatgtc tcctgaggag tttgacgagg tgtctcggat agtgggctct     2220

gtagaattcg acagtatgat gaacacagta tag                                  2253


<210>  529
<211>  2385
<212>  DNA
<213>  Homo sapiens;

<400>  529
atggcgggct ggatccaggc ccagcagctg cagggagacg cgctgcgcca gatgcaggtg       60

ctgtacggcc agcacttccc catcgaggtc cggcactact tggcccagtg gattgagagc      120

cagccatggg atgccattga cttggacaat ccccaggaca gagcccaagc cacccagctc      180

ctggagggcc tggtgcagga gctgcagaag aaggcggagc accaggtggg ggaagatggg      240

tttttactga agatcaagct ggggcactac gccacgcagc tccagaaaac atatgaccgc      300

tgccccctgg agctggtccg ctgcatccgg cacattctgt acaatgaaca gaggctggtc      360

cgagaagcca acaattgcag ctctccggct gggatcctgg ttgacgccat gtcccagaag      420

caccttcaga tcaaccagac atttgaggag ctgcgactgg tcacgcagga cacagagaat      480

gagctgaaga aactgcagca gactcaggag tacttcatca tccagtacca ggagagcctg      540

aggatccaag ctcagtttgc ccagctggcc cagctgagcc cccaggagcg tctgagccgg      600

gagacggccc tccagcagaa gcaggtgtct ctggaggcct ggttgcagcg tgaggcacag      660

acactgcagc agtaccgcgt ggagctggcc gagaagcacc agaagaccct gcagctgctg      720

cggaagcagc agaccatcat cctggatgac gagctgatcc agtggaagcg gcggcagcag      780

ctggccggga acggcgggcc ccccgagggc agcctggacg tgctacagtc ctggtgtgag      840

aagttggccg agatcatctg gcagaaccgg cagcagatcc gcagggctga gcacctctgc      900

cagcagctgc ccatccccgg cccagtggag gagatgctgg ccgaggtcaa cgccaccatc      960

acggacatta tctcagccct ggtgaccagc acattcatca ttgagaagca gcctcctcag     1020

gtcctgaaga cccagaccaa gtttgcagcc accgtacgcc tgctggtggg cgggaagctg     1080

aacgtgcaca tgaatccccc ccaggtgaag gccaccatca tcagtgagca gcaggccaag     1140

tctctgctta aaaatgagaa cacccgcaac gagtgcagtg gtgagatcct gaacaactgc     1200

tgcgtgatgg agtaccacca agccacgggc accctcagtg cccacttcag gaacatgtca     1260

ctgaagagga tcaagcgtgc tgaccggcgg ggtgcagagt ccgtgacaga ggagaagttc     1320

acagtcctgt ttgagtctca gttcagtgtt ggcagcaatg agcttgtgtt ccaggtgaag     1380

actctgtccc tacctgtggt tgtcatcgtc cacggcagcc aggaccacaa tgccacggct     1440

actgtgctgt gggacaatgc ctttgctgag ccgggcaggg tgccatttgc cgtgcctgac     1500

aaagtgctgt ggccgcagct gtgtgaggcg ctcaacatga aattcaaggc cgaagtgcag     1560

agcaaccggg gcctgaccaa ggagaacctc gtgttcctgg cgcagaaact gttcaacaac     1620

agcagcagcc acctggagga ctacagtggc ctgtccgtgt cctggtccca gttcaacagg     1680

gagaacttgc cgggctggaa ctacaccttc tggcagtggt ttgacggggt gatggaggtg     1740

ttgaagaagc accacaagcc ccactggaat gatggggcca tcctaggttt tgtgaataag     1800

caacaggccc acgacctgct catcaacaag cccgacggga ccttcttgtt gcgctttagt     1860

gactcagaaa tcgggggcat caccatcgcc tggaagtttg actccccgga acgcaacctg     1920

tggaacctga aaccattcac cacgcgggat ttctccatca ggtccctggc tgaccggctg     1980

ggggacctga gctatctcat ctatgtgttt cctgaccgcc ccaaggatga ggtcttctcc     2040

aagtactaca ctcctgtgct ggctaaagct gttgatggat atgtgaaacc acagatcaag     2100

caagtggtcc ctgagtttgt gaatgcatct gcagatgctg ggggcagcag cgccacgtac     2160

atggaccagg ccccctcccc agctgtgtgc ccccaggctc cctataacat gtacccacag     2220

aaccctgacc atgtactcga tcaggatgga gaattcgacc tggatgagac catggatgtg     2280

gccaggcacg tggaggaact cttacgccga ccaatggaca gtcttgactc ccgcctctcg     2340

ccccctgccg gtcttttcac ctctgccaga ggctccctct catga                     2385


<210>  530
<211>  2364
<212>  DNA
<213>  Homo sapiens;

<400>  530
atggctgtgt ggatacaagc tcagcagctc caaggagaag cccttcatca gatgcaagcg       60

ttatatggcc agcattttcc cattgaggtg cggcattatt tatcccagtg gattgaaagc      120

caagcatggg actcagtaga tcttgataat ccacaggaga acattaaggc cacccagctc      180

ctggagggcc tggtgcagga gctgcagaag aaggcagagc accaggtggg ggaagatggg      240

tttttactga agatcaagct ggggcactat gccacacagc tccagaacac gtatgaccgc      300

tgccccatgg agctggtccg ctgcatccgc catatattgt acaatgaaca gaggttggtc      360

cgagaagcca acaatggtag ctctccagct ggaagccttg ctgatgccat gtcccagaaa      420

cacctccaga tcaaccagac gtttgaggag ctgcgactgg tcacgcagga cacagagaat      480

gagttaaaaa agctgcagca gactcaggag tacttcatca tccagtacca ggagagcctg      540

aggatccaag ctcagtttgg cccgctggcc cagctgagcc cccaggagcg tctgagccgg      600

gagacggccc tccagcagaa gcaggtgtct ctggaggcct ggttgcagcg tgaggcacag      660

acactgcagc agtaccgcgt ggagctggcc gagaagcacc agaagaccct gcagctgctg      720

cggaagcagc agaccatcat cctggatgac gagctgatcc agtggaagcg gcggcagcag      780

ctggccggga acggcgggcc ccccgagggc agcctggacg tgctacagtc ctggtgtgag      840

aagttggccg agatcatctg gcagaaccgg cagcagatcc gcagggctga gcacctctgc      900

cagcagctgc ccatccccgg cccagtggag gagatgctgg ccgaggtcaa cgccaccatc      960

acggacatta tctcagccct ggtgaccagc acgttcatca ttgagaagca gcctcctcag     1020

gtcctgaaga cccagaccaa gtttgcagcc actgtgcgcc tgctggtggg cgggaagctg     1080

aacgtgcaca tgaacccccc ccaggtgaag gccaccatca tcagtgagca gcaggccaag     1140

tctctgctca agaacgagaa cacccgcaat gattacagtg gcgagatctt gaacaactgc     1200

tgcgtcatgg agtaccacca agccacaggc acccttagtg cccacttcag gaatatgtcc     1260

ctgaaacgaa ttaagaggtc agaccgtcgt ggggcagagt cggtgacaga agaaaaattt     1320

acaatcctgt ttgaatccca gttcagtgtt ggtggaaatg agctggtttt tcaagtcaag     1380

accctgtccc tgccagtggt ggtgatcgtt catggcagcc aggacaacaa tgcgacggcc     1440

actgttctct gggacaatgc ttttgcagag cctggcaggg tgccatttgc cgtgcctgac     1500

aaagtgctgt ggccacagct gtgtgaggcg ctcaacatga aattcaaggc cgaagtgcag     1560

agcaaccggg gcctgaccaa ggagaacctc gtgttcctgg cgcagaaact gttcaacaac     1620

agcagcagcc acctggagga ctacagtggc ctgtctgtgt cctggtccca gttcaacagg     1680

gagaatttac caggacggaa ttacactttc tggcaatggt ttgacggtgt gatggaagtg     1740

ttaaaaaaac atctcaagcc tcattggaat gatggggcca ttttggggtt tgtaaacaag     1800

caacaggccc atgacctact cattaacaag ccagatggga ccttcctcct gagattcagt     1860

gactcagaaa ttggcggcat caccattgct tggaagtttg attctcagga aagaatgttt     1920

tggaatctga tgccttttac caccagagac ttctccattc ggtccctagc cgaccgcttg     1980

ggagacttga attaccttat ctacgtgttt cctgatcggc caaaagatga agtatactcc     2040

aaatactaca caccagttcc ctgcgagtct gctactgcta aagctgttga tggatacgtg     2100

aagccacaga tcaagcaagt ggtccctgag tttgtgaacg catctgcaga tgccgggggc     2160

ggcagcgcca cgtacatgga ccaggccccc tccccagctg tgtgtcccca ggctcactat     2220

aacatgtacc cacagaaccc tgactcagtc cttgacaccg atggggactt cgatctggag     2280

gacacaatgg acgtagcgcg gcgtgtggag gagctcctgg gccggccaat ggacagtcag     2340

tggatcccgc acgcacaatc gtga                                            2364


<210>  531
<211>  1395
<212>  DNA
<213>  Homo sapiens;

<400>  531
atggcaatga cggcagggac tacaacaacc tttcctatga gcaaccatac ccgggaaaga       60

gtgactgtag ccaagctcac attggagaat ttttatagca acctaatttt acagcatgaa      120

gagagagaaa ccaggcagaa gaaattagaa gtggccatgg aagaagaagg attagcagat      180

gaagagaaaa agttacgtcg atcacaacac gctcgcaaag aaacagagtt cttacggctc      240

aaaaggacca gacttggctt ggatgacttt gagtctctga aagttatagg aagaggagct      300

tttggagagg tgcggttggt ccagaagaaa gatacaggcc atatctatgc aatgaagata      360

ttgagaaagt ctgatatgct tgaaaaagag caggtggccc atatccgagc agaaagagat      420

attttggtag aagcagatgg tgcctgggtg gtgaagatgt tttacagttt tcaggataag      480

aggaatcttt atctaatcat ggaatttctc cctggaggtg acatgatgac attgctaatg      540

aagaaagaca ccttgacaga agaggaaaca cagttctaca tttcagagac tgttctggca      600

atagatgcga tccaccagtt gggtttcatc catcgggata ttaagccaga caacctttta      660

ttggatgcca agggtcatgt aaaattatct gattttggtt tatgtacggg attaaagaaa      720

gctcacagga ctgaatttta tagaaatctc acacacaacc caccaagtga cttctcattt      780

cagaacatga actcaaagag gaaagcagaa acttggaaga agaacaggag acaactggca      840

tattccacag ttgggacacc agattacatt gctccagaag tattcatgca gactggttac      900

aacaaattgt gtgactggtg gtctttggga gtgattatgt atgaaatgct aataggatat      960

ccacctttct gctctgaaac acctcaagaa acgtacagaa aagtgatgaa ctggaaagaa     1020

actctggtat ttcctccaga ggtacctata tctgagaaag ccaaggactt aattctcaga     1080

ttttgtattg attctgaaaa cagaattgga aatagtggag tagaagaaat aaaaggtcat     1140

cccttttttg aaggtgtcga ctgggagcac ataagggaaa ggccagcagc aatccctata     1200

gaaatcaaaa gcattgatga tacttcaaat tttgatgact tccctgaatc tgatatttta     1260

caaccagtgc caaataccac agaaccggac tacaaatcca aagactgggt ttttctcaat     1320

tatacctata aaaggtttga agggttgact caacgtggct ctatccccac ctacatgaaa     1380

gctgggaagt tatga                                                      1395


<210>  532
<211>  750
<212>  DNA
<213>  Homo sapiens;

<400>  532
atgtctctcg aagacccctt ttttgtagtc cgaggcgagg tgcagaaggc ggtgaacacg       60

gcccgcgggc tgtaccagcg ctggtgcgag ctcctgcagg aaagcgcggc ggtcggacgc      120

gaggagctgg actggacgac caatgagctg cggaatggcc tgcgcagcat cgagtgggac      180

ctcgaggacc tggaagagac catcggtata gtggaagcca acccaggcaa gttcaagctc      240

ccagccgggg acctgcagga gagaaaggtg ttcgtggagc ggatgcgaga ggcagtccag      300

gaaatgaagg accatatggt cagcccaaca gccgtagcat ttttggagag gaataacaga      360

gagatactcg caggcaagcc agctgcccag aagtcaccca gcgacctgct ggatgccagc      420

gcagtctcgg ccacatctcg ctacatcgag gagcagcagg ccacacagca gctgatcatg      480

gatgaacagg atcaacagct ggagatggtg tctgggagca tccaggttct gaagcacatg      540

tccggccgcg ttggagaaga gctggacgag cagggcatca tgctggatgc cttcgcccaa      600

gagatggacc acacccagtc ccgcatggac ggggtcctca ggaagttggc caaagtatcc      660

cacatgacga gtgaccgccg acagtggtgt gccatcgccg tgctagtggg ggtgcttctc      720

ctcgttctca tcttactatt ctctctctga                                       750


<210>  533
<211>  870
<212>  DNA
<213>  Homo sapiens;

<400>  533
atgaaggacc gtctggagca gctgaaggcc aagcagctga cacaggatga tgatactgat       60

gcggttgaga ttgctatcga caacacggct tttatggacg agttcttttc tgagattgag      120

gaaactcggc ttaacattga caagatctca gaacatgtag aggaggctaa gaaactctac      180

agtatcattc tctctgcacc gattccagag ccaaaaacca aggatgacct agagcagctc      240

acgactgaga ttaagaaaag ggccaacaac gtccggaaca aactgaagag catggagaag      300

catattgaag aagatgaggt caggtcatcg gcagaccttc ggattcggaa atcccagcac      360

tctgtccttt ctcggaagtt tgtggaggtg atgaccaaat acaatgaagc tcaagtggac      420

ttccgagaac gcagcaaagg gcgaatccag cggcagctcg aaattactgg caaaaagaca      480

accgatgagg agctggagga gatgttggag agtggcaacc cggccatctt cacttctggg      540

atcattgact cacagatttc caagcaagcc ctcagtgaga ttgagggacg acacaaggac      600

attgtgaggc tggagagcag catcaaggag cttcacgaca tgtttatgga catcgccatg      660

ctggtggaga atcagggtga gatgttagat aacatagagt tgaatgtcat gcacacagtg      720

gaccacgtgg agaaggcacg agatgaaacg aaaaaagctg tgaaatacca gagtcaggcc      780

cggaagaaat tgataattat cattgtgcta gtagttgtgt tgctgggcat tttagcattg      840

attattggac tttccgttgg gctgaattaa                                       870


<210>  534
<211>  768
<212>  DNA
<213>  Homo sapiens;

<400>  534
atgtccatgg aggacccctt ctttgtggtg aaaggagagg tacagaaagc agtcaacact       60

gcccagggat tgtttcagag atggacagag ctcctccagg acccctccac agcaacaagg      120

gaagaaatcg actggaccac caacgagctg agaaataacc tccggagcat agagtgggat      180

ctagaggacc ttgatgaaac catcagcata gttgaagcaa atcctagaaa atttaacctt      240

gatgcaactg aattgagtat aagaaaagcc ttcattacaa gtactcggca agttgtcagg      300

gacatgaaag atcagatgtc aacttcatct gtgcaggcat tagctgaaag aaaaaataga      360

caggcactgc tgggagacag tggcagccag aactggagca ctggaacaac agataaatat      420

gggcgtctgg accgagagct ccagagagcc aattctcatt tcattgagga gcagcaggca      480

cagcagcagt tgatcgtgga acagcaggat gagcagttgg agctggtctc tggcagcatc      540

ggggtgctga agaacatgtc ccagcgcatc ggaggggagc tggaggaaca ggcagttatg      600

ttggaagatt tctctcacga attggagagc actcagtccc ggctggacaa tgtgatgaag      660

aaacttgcaa aagtatctca tatgaccagt gatcggcgcc aatggtgtgc catagccatc      720

ctctttgcag tcctgttggt tgtgctcatc ctcttcttag tgctgtga                   768


<210>  535
<211>  780
<212>  DNA
<213>  Homo sapiens;

<400>  535
atggcgccca acatctactt ggttcgccag cggatcagtc gactcggcca gaggatgtcc       60

ggcttccaga tcaacctcaa cccgctcaag gagccactcg gcttcatcaa ggtcctcgag      120

tggattgctt ctatctttgc ttttgccacc tgtggaggtt ttaagggcca aacagaaatt      180

caagtgaatt gtcctcctgc agttactgag aataaaactg ttacagctac ttttggttat      240

ccattcaggt tgaatgaggc atcatttcag ccacctccag gtgtaaacat atgtgatgta      300

aattggaaag attacgtcct cataggcgat tactcttctt ctgcacaatt ctatgttacc      360

tttgcagtct ttgtgttcct gtactgcatt gctgcccttc tgctttatgt tggctacacg      420

agtctgtatc tggatagtcg taaacttcct atgatagact ttgttgttac acttgttgcc      480

acttttttgt ggttggtgag cacttcagcc tgggctaaag ctctgacaga tattaaaata      540

gctactggtc acaatattat tgatgaactt ccgccttgta agaagaaagc agtactgtgt      600

tactttggct ctgtgaccag tatgggatcc ctaaatgtat ctgtgatatt tggctttcta      660

aatatgatac tctggggagg aaatgcttgg tttgtgtaca aggagaccag cctacacagt      720

ccatcaaata catctgcccc tcatagccaa ggaggtattc cacctcctac cggaatataa      780


<210>  536
<211>  2427
<212>  DNA
<213>  Homo sapiens;

<400>  536
atggctgagc ttctcgccag cgcaggatca gcctgttcct gggactttcc gagagccccg       60

ccctcgttcc ctcccccagc cgccagtagg ggaggactcg gcggtacccg gagcttcagg      120

ccccaccggg gcgcggagag tcccaggccc ggccgggacc gggacggcgt ccgagtgcca      180

atggctagct ctaggtgtcc cgctccccgc gggtgccgct gcctccccgg agcttctctc      240

gcatggctgg ggacagtact gctacttctc gccgactggg tgctgctccg gaccgcgctg      300

ccccgcatat tctccctgct ggtgcccacc gcgctgccac tgctccgggt ctgggcggtg      360

ggcctgagcc gctgggccgt gctctggctg ggggcctgcg gggtcctcag ggcaacgggt      420

ggctccaaga gcgaaaacgc aggtgcccag ggctggctgg ctgctttgaa gccattagct      480

gcggcactgg gcttggccct gccgggactt gccttgttcc gagagctgat ctcatgggga      540

gcccccgggt ccgcggatag caccaggcta ctgcactggg gaagtcaccc taccgccttc      600

gttgtcagtt atgcagcggc actgcccgca gcagccctgt ggcacaaact cgggagcctc      660

tgggtgcccg gcggtcaggg cggctctgga aaccctgtgc gtcggcttct aggctgcctg      720

ggctcggaga cgcgccgcct ctcgctgttc ctggtcctgg tggtcctctc ctctcttggg      780

gagatggcca ttccattctt tacgggccgc ctcactgact ggattctaca agatggctca      840

gccgatacct tcactcgaaa cttaactctc atgtccattc tcaccatagc cagtgcagtg      900

ctggagttcg tgggtgacgg gatctataac aacaccatgg gccacgtgca cagccacttg      960

cagggagagg tgtttggggc tgtcctgcgc caggagacgg agtttttcca acagaaccag     1020

acaggtaaca tcatgtctcg ggtaacagag gacacgtcca ccctgagtga ttctctgagt     1080

gagaatctga gcttatttct gtggtacctg gtgcgaggcc tatgtctctt ggggatcatg     1140

ctctggggat cagtgtccct caccatggtc accctgatca ccctgcctct gcttttcctt     1200

ctgcccaaga aggtgggaaa atggtaccag ttgctggaag tgcaggtgcg ggaatctctg     1260

gcaaagtcca gccaggtggc cattgaggct ctgtcggcca tgcctacagt tcgaagcttt     1320

gccaacgagg agggcgaagc ccagaagttt agggaaaagc tgcaagaaat aaagacactc     1380

aaccagaagg aggctgtggc ctatgcagtc aactcctgga ccactagtat ttcaggtatg     1440

ctgctgaaag tgggaatcct ctacattggt gggcagctgg tgaccagtgg ggctgtaagc     1500

agtgggaacc ttgtcacatt tgttctctac cagatgcagt tcacccaggc tgtggaggta     1560

ctgctctcca tctaccccag agtacagaag gctgtgggct cctcagagaa aatatttgag     1620

tacctggacc gcacccctcg ctgcccaccc agtggtctgt tgactccctt acacttggag     1680

ggccttgtcc agttccaaga tgtctccttt gcctacccaa accgcccaga tgtcttagtg     1740

ctacaggggc tgacattcac cctacgccct ggcgaggtga cggcgctggt gggacccaat     1800

gggtctggga agagcacagt ggctgccctg ctgcagaatc tgtaccagcc caccggggga     1860

cagctgctgt tggatgggaa gccccttccc caatatgagc accgctacct gcacaggcag     1920

gtggctgcag tgggacaaga gccacaggta tttggaagaa gtcttcaaga aaatattgcc     1980

tatggcctga cccagaagcc aactatggag gaaatcacag ctgctgcagt aaagtctggg     2040

gcccatagtt tcatctctgg actccctcag ggctatgaca cagaggtaga cgaggctggg     2100

agccagctgt cagggggtca gcgacaggca gtggcgttgg cccgagcatt gatccggaaa     2160

ccgtgtgtac ttatcctgga tgatgccacc agtgccctgg atgcaaacag ccagttacag     2220

gtggagcagc tcctgtacga aagccctgag cggtactccc gctcagtgct tctcatcacc     2280

cagcacctca gcctggtgga gcaggctgac cacatcctct ttctggaagg aggcgctatc     2340

cgggaggggg gaacccacca gcagctcatg gagaaaaagg ggtgctactg ggccatggtg     2400

caggctcctg cagatgctcc agaatga                                         2427


<210>  537
<211>  1728
<212>  DNA
<213>  Homo sapiens;

<400>  537
atgtctcatg cggccgaacc agctcgggat ggcgtagagg ccagcgcgga gggccctcga       60

gccgtgttcg tgctgttgga ggagcgcagg ccggccgact cggctcagct gctcagcctg      120

aactctttgc ttccggaatc cgggattgtt gctgacatag aattagaaaa cgtccttgat      180

cctgacagct tctacgagct caaaagccaa cccttacccc ttcgctcaag cctcccaata      240

tcactgcagg ccacaccagc caccccagct acactctctg catcgtcttc tgcagggggc      300

tccaggaccc ctgccatgtc gtcatcttct tcatcgaggg tcttgctgcg gcagcagcta      360

atgcgggccc aggcgcagga gcaggagagg cgtgagcgtc gggaacaggc cgccgcggct      420

cccttcccca gtcctgcacc tgcctctcct gccatctctg tggttggcgt ctctgctggg      480

ggccacacat tgagccgtcc accccctgct caggtgccca gggaggtgct caaggtgcag      540

acccatctgg agaacccaac gcgctaccac ctgcagcagg cgcgccggca gcaggtgaaa      600

cagtacctgt ccaccacact cgggcccaag ctggcttccc aggccctcac cccaccgccg      660

gggcccgcaa gtgcccagcc actgcctgcc cctgaggctg cccacactac cggccccaca      720

ggcagtgcgc ccaacagccc catggcgctg ctcaccatcg ggtccagctc agagaaggag      780

attgatgatg tcattgatga gatcatcagc ctggagtcca gttacaatga tgaaatgctc      840

agctatctgc ccggaggcac cacaggactg cagctcccca gcacgctgcc tgtgtcaggg      900

aatctgcttg atgtgtacag tagtcaaggc gtggccacac cagccatcac tgtcagcaac      960

tcctgcccag ctgagctgcc caacatcaaa cgggagatct ctgagaccga ggcaaaggcc     1020

cttttgaagg aacggcagaa gaaagacaat cacaacctaa ttgagcgtcg caggcgattc     1080

aacattaacg acaggatcaa ggaactgggc actctcatcc ctaagtccag tgacccggag     1140

atgcgctgga acaagggcac catcctgaag gcctctgtgg attatatccg caagctgcag     1200

aaggagcagc agcgctccaa agacctggag agccggcagc gatccctgga gcaggccaac     1260

cgcagcctgc agctccgaat tcaggaacta gaactgcagg cccagatcca tggcctgcca     1320

gtacctccca ctccagggct gctttccttg gccacgactt cggcttctga cagcctcaag     1380

ccagagcagc tggacattga ggaggagggc aggccaggcg cagcaacgtt ccatgtaggg     1440

gggggacctg cccagaatgc tccccatcag cagccccctg caccgccctc agatgccctt     1500

ctggacctgc actttcccag cgaccacctg ggggacctgg gagacccctt ccacctgggg     1560

ctggaggaca ttctgatgga ggaggaggag ggggtggtgg gaggactgtc ggggggtgcc     1620

ctgtccccac tgcgggctgc ctccgatccc ctgctctctt cagtgtcccc tgctgtctcc     1680

aaggccagca gccgccgcag cagcttcagc atggaagagg agtcctga                  1728


<210>  538
<211>  1431
<212>  DNA
<213>  Homo sapiens;

<400>  538
atggcgtcac gcatagggtt gcgcatgcag ctcatgcggg agcaggcgca gcaggaggag       60

cagcgggagc gcatgcagca acaggctgtc atgcattaca tgcagcagca gcagcagcag      120

caacagcagc agctcggagg gccgcccacc ccggccatca atacccccgt ccacttccag      180

tcgccaccac ctgtgcctgg ggaggtgttg aaggtgcagt cctacctgga gaatcccaca      240

tcctaccatc tgcagcagtc gcagcatcag aaggtgcggg agtacctgtc cgagacctat      300

gggaacaagt ttgctgccca catcagccca gcccagggct ctccgaaacc cccaccagcc      360

gcctccccag gggtgcgagc tggacacgtg ctgtcctcct ccgctggcaa cagtgctccc      420

aatagcccca tggccatgct gcacattggc tccaaccctg agagggagtt ggatgatgtc      480

attgacaaca ttatgcgtct ggacgatgtc cttggctaca tcaatcctga aatgcagatg      540

cccaacacgc tacccctgtc cagcagccac ctgaatgtgt acagcagcga cccccaggtc      600

acagcctccc tggtgggcgt caccagcagc tcctgccctg cggacctgac ccagaagcga      660

gagctcacag atgctgagag cagggccctg gccaaggagc ggcagaagaa agacaatcac      720

aacttaattg aaaggagacg aaggttcaac atcaatgacc gcatcaagga gttgggaatg      780

ctgatcccca aggccaatga cctggacgtg cgctggaaca agggcaccat cctcaaggcc      840

tctgtggatt acatccggag gatgcagaag gacctgcaaa agtccaggga gctggagaac      900

cactctcgcc gcctggagat gaccaacaag cagctctggc tccgtatcca ggagctggag      960

atgcaggctc gagtgcacgg cctccctacc acctccccgt ccggcatgaa catggctgag     1020

ctggcccagc aggtggtgaa gcaggagctg cctagcgaag agggcccagg ggaggccctg     1080

atgctggggg ctgaggtccc tgaccctgag ccactgccag ctctgccccc gcaagccccg     1140

ctgcccctgc ccacccagcc accatcccca ttccatcacc tggacttcag ccacagcctg     1200

agctttgggg gcagggagga cgagggtccc ccgggctacc ccgaacccct ggcgccgggg     1260

catggctccc cattccccag cctgtccaag aaggatctgg acctcatgct cctggacgac     1320

tcactgctac cgctggcctc tgatccactt ctgtccacca tgtcccccga ggcctccaag     1380

gccagcagcc gccggagcag cttcagcatg gaggagggcg atgtgctgtg a              1431


<210>  539
<211>  2052
<212>  DNA
<213>  Homo sapiens;

<400>  539
atggcgctct tcgtgcggct gctggctctc gccctggctc tggccctggg ccccgccgcg       60

accctggcgg gtcccgccaa gtcgccctac cagctggtgc tgcagcacag caggctccgg      120

ggccgccagc acggccccaa cgtgtgtgct gtgcagaagg ttattggcac taataggaag      180

tacttcacca actgcaagca gtggtaccaa aggaaaatct gtggcaaatc aacagtcatc      240

agctacgagt gctgtcctgg atatgaaaag gtccctgggg agaagggctg tccagcagcc      300

ctaccactct caaaccttta cgagaccctg ggagtcgttg gatccaccac cactcagctg      360

tacacggacc gcacggagaa gctgaggcct gagatggagg ggcccggcag cttcaccatc      420

ttcgccccta gcaacgaggc ctgggcctcc ttgccagctg aagtgctgga ctccctggtc      480

agcaatgtca acattgagct gctcaatgcc ctccgctacc atatggtggg caggcgagtc      540

ctgactgatg agctgaaaca cggcatgacc ctcacctcta tgtaccagaa ttccaacatc      600

cagatccacc actatcctaa tgggattgta actgtgaact gtgcccggct gctgaaagcc      660

gaccaccatg caaccaacgg ggtggtgcac ctcatcgata aggtcatctc caccatcacc      720

aacaacatcc agcagatcat tgagatcgag gacacctttg agacccttcg ggctgctgtg      780

gctgcatcag ggctcaacac gatgcttgaa ggtaacggcc agtacacgct tttggccccg      840

accaatgagg ccttcgagaa gatccctagt gagactttga accgtatcct gggcgaccca      900

gaagccctga gagacctgct gaacaaccac atcttgaagt cagctatgtg tgctgaagcc      960

atcgttgcgg ggctgtctgt agagaccctg gagggcacga cactggaggt gggctgcagc     1020

ggggacatgc tcactatcaa cgggaaggcg atcatctcca ataaagacat cctagccacc     1080

aacggggtga tccactacat tgatgagcta ctcatcccag actcagccaa gacactattt     1140

gaattggctg cagagtctga tgtgtccaca gccattgacc ttttcagaca agccggcctc     1200

ggcaatcatc tctctggaag tgagcggttg accctcctgg ctcccctgaa ttctgtattc     1260

aaagatggaa cccctccaat tgatgcccat acaaggaatt tgcttcggaa ccacataatt     1320

aaagaccagc tggcctctaa gtatctgtac catggacaga ccctggaaac tctgggcggc     1380

aaaaaactga gagtttttgt ttatcgtaat agcctctgca ttgagaacag ctgcatcgcg     1440

gcccacgaca agagggggag gtacgggacc ctgttcacga tggaccgggt gctgaccccc     1500

ccaatgggga ctgtcatgga tgtcctgaag ggagacaatc gctttagcat gctggtagct     1560

gccatccagt ctgcaggact gacggagacc ctcaaccggg aaggagtcta cacagtcttt     1620

gctcccacaa atgaagcctt ccgagccctg ccaccaagag aacggagcag actcttggga     1680

gatgccaagg aacttgccaa catcctgaaa taccacattg gtgatgaaat cctggttagc     1740

ggaggcatcg gggccctggt gcggctaaag tctctccaag gtgacaagct ggaagtcagc     1800

ttgaaaaaca atgtggtgag tgtcaacaag gagcctgttg ccgagcctga catcatggcc     1860

acaaatggcg tggtccatgt catcaccaat gttctgcagc ctccagccaa cagacctcag     1920

gaaagagggg atgaacttgc agactctgcg cttgagatct tcaaacaagc atcagcgttt     1980

tccagggctt cccagaggtc tgtgcgacta gcccctgtct atcaaaagtt attagagagg     2040

atgaagcatt ag                                                         2052


<210>  540
<211>  1704
<212>  DNA
<213>  Homo sapiens;

<400>  540
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcaacc      600

tgggaaaccg gcaagacgcg gaagctcatg gagttcagcg agcactgtgc catcatcctg      660

gaagatgacc gctctgacat cagctccacg tgtgccaaca acatcaacca caacacagag      720

ctgctgccca ttgagctgga caccctggtg gggaaaggtc gctttgctga ggtctataag      780

gccaagctga agcagaacac ttcagagcag tttgagacag tggcagtcaa gatctttccc      840

tatgaggagt atgcctcttg gaagacagag aaggacatct tctcagacat caatctgaag      900

catgagaaca tactccagtt cctgacggct gaggagcgga agacggagtt ggggaaacaa      960

tactggctga tcaccgcctt ccacgccaag ggcaacctac aggagtacct gacgcggcat     1020

gtcatcagct gggaggacct gcgcaagctg ggcagctccc tcgcccgggg gattgctcac     1080

ctccacagtg atcacactcc atgtgggagg cccaagatgc ccatcgtgca cagggacctc     1140

aagagctcca atatcctcgt gaagaacgac ctaacctgct gcctgtgtga ctttgggctt     1200

tccctgcgtc tggaccctac tctgtctgtg gatgacctgg ctaacagtgg gcaggtggga     1260

actgcaagat acatggctcc agaagtccta gaatccagga tgaatttgga gaatgttgag     1320

tccttcaagc agaccgatgt ctactccatg gctctggtgc tctgggaaat gacatctcgc     1380

tgtaatgcag tgggagaagt aaaagattat gagcctccat ttggttccaa ggtgcgggag     1440

cacccctgtg tcgaaagcat gaaggacaac gtgttgagag atcgagggcg accagaaatt     1500

cccagcttct ggctcaacca ccagggcatc cagatggtgt gtgagacgtt gactgagtgc     1560

tgggaccacg acccagaggc ccgtctcaca gcccagtgtg tggcagaacg cttcagtgag     1620

ctggagcatc tggacaggct ctcggggagg agctgctcgg aggagaagat tcctgaagac     1680

ggctccctaa acactaccaa atag                                            1704


<210>  541
<211>  1314
<212>  DNA
<213>  Homo sapiens;

<400>  541
atgcggttcg tggttgcctt ggtcctcctg aacgtcgcag cggcgggagc cgtgccgctc       60

ttggccaccg aaagcgtcaa gcaagaagaa gctggagtac ggccttctgc aggaaacgtc      120

tccacccacc ccagcttgag ccaacggcct ggaggctcta ccaagtcgca tccggagccg      180

cagactccaa aagacagccc tagcaagtcg agtgcggagg cgcagacccc agaagacacc      240

cccaacaagt cgggtgcgga ggcaaagacc caaaaagaca gctccaacaa gtcgggtgcg      300

gaggcaaaga cccaaaaagg cagcactagc aagtcgggtt cggaggcgca gaccacaaaa      360

gacagcacta gtaagtcgca tccggagctg cagactccaa aagacagcac tggcaaatcg      420

ggtgcggagg cgcagacccc agaagacagc cccaacaggt cgggtgcgga ggcaaagacc      480

caaaaagaca gccctagcaa gtcaggttcg gaggcgcaga ccacaaaaga tgtccctaat      540

aagtcgggtg cggacggcca gaccccaaaa gacggctcca gcaagtcggg tgcggaggat      600

cagaccccaa aagacgtccc taacaagtcg ggtgcggaga agcagactcc aaaagacggc      660

tctaacaagt ccggtgcaga ggagcagggc ccaatagacg ggcccagcaa gtcgggtgcg      720

gaggagcaga cctcaaaaga cagccctaac aaggtggttc cagagcagcc ttcccggaaa      780

gaccattcca agcccatctc caacccttct gataacaagg agctccccaa ggctgacaca      840

aaccagcttg ctgacaaagg gaagctttct cctcatgctt tcaaaaccga atctggggag      900

gaaactgacc tcatttctcc cccgcaggag gaagttaagt cttcagagcc tactgaggat      960

gtggagccca aagaggctga agatgatgat acaggacccg aggagggctc accgcccaaa     1020

gaagagaaag aaaagatgtc cggttctgcc tccagtgaga accgtgaagg gacactttcg     1080

gattccacgg gtagcgagaa ggatgacctt tatccgaacg gttctggaaa tggcagcgcg     1140

gagagcagcc acttctttgc atatctggtg actgcagcca ttcttgtggc tgtcctctat     1200

atcgctcatc acaacaagcg gaagatcatt gcttttgtcc tggaaggaaa aagatctaaa     1260

gtcacccggc ggccaaaggc cagtgactac caacgtttgg accagaagtc ctaa           1314


<210>  542
<211>  4776
<212>  DNA
<213>  Homo sapiens;

<400>  542
atgggaaacg cagaaagtca acatgtagag cacgagtttt atggagaaaa gcatgccagc       60

ctggggcgca agcacacttc ccgctccctg cgcctctcgc acaagacgcg gaggaccagg      120

cacgcttcct cggggaaggt gatccacagg aactccgaag tgagcacccg atccagcagc      180

acccccagca tcccccagtc cctggctgaa aatggcctgg agcccttctc ccaagatggt      240

accctagaag acttcgggag ccccatctgg gtggaccgag tggacatggg cttgagacct      300

gtgtcttaca ctgactcttc tgtcactccc agcgtagaca gcagcatcgt cctcacagca      360

gcctctgtgc agagcatgcc agacactgag gagagcaggc tttacgggga tgacgctaca      420

tatttggctg agggaggcag gaggcagcat tcctatacat ccaatgggcc cactttcatg      480

gagacggcga gctttaagaa gaaacgctcc aaatctgcag acatctggcg ggaggacagc      540

ctggaattct cactctctga tctgagccaa gaacatttaa caagcaacga agaaatcttg      600

ggttccgccg aagagaagga ctgcgaggag gctcggggga tggaaacgcg ggcgagtccg      660

cggcagctca gcacctgtca gagagccaat tccttgggtg acttgtatgc tcagaaaaac      720

tctggagtga cagcaaacgg ggggccgggg agcaaatttg caggctactg tcggaatttg      780

gtgtctgata ttcccaatct tgcaaaccat aagatgccac cagctgctgc tgaagagact      840

cctccgtaca gtaattataa cacacttccc tgtaggaaat ctcactgtct ctctgaaggt      900

gccaccaacc cacaaattag ccatagcaac agcatgcaag gcagaagagc taaaacaact      960

caggatgtta atgcaggcga gggcagtgag tttgcagaca gtgggattga aggggccact     1020

accgacacgg acctcctgtc caggcgatct aatgccacca actccagcta ctcacccacc     1080

acaggccggg cctttgtggg cagcgacagc ggcagcagct ccaccgggga tgcggctcgt     1140

cagggggtgt acgagaactt ccggcgggag ctggagatga gcaccaccaa cagcgagagc     1200

ctggaggagg ccggctcggc gcacagcgat gagcagagca gcggcaccct gagctctccg     1260

ggccagtcgg acatcctgct gaccgccgca cagggcacgg tgcgcaaggc cggcgccctg     1320

gccgtcaaga acttcctggt gcacaagaag aacaagaagg tggagtcagc cacccggagg     1380

aagtggaagc actactgggt gtccctgaaa ggatgcacgc tatttttcta cgagagcgac     1440

ggcaggtctg ggatagacca caacagcatc cccaaacacg ccgtctgggt ggagaacagc     1500

attgtgcagg cggtgcctga gcaccccaag aaggactttg tcttctgcct cagcaattcc     1560

ctgggtgatg ccttcctttt tcagaccact agccagacgg agcttgaaaa ctggatcacc     1620

gccatccact ctgcctgcgc cactgcggtc gcgaggcacc accacaagga agacacgctc     1680

cgactcctga aatcagagat caaaaaactg gaacagaaga ttgacatgga tgaaaagatg     1740

aagaaaatgg gtgaaatgca gctgtcttca gtcactgact caaagaaaaa gaaaacaata     1800

ttagatcaga tctttgtctg ggagcaaaat ctcgagcagt tccaaatgga cctgtttcgt     1860

ttccgctgtt atttagccag ccttcagggt ggggagctgc caaaccccaa aaggcttctc     1920

gcttttgcaa gtcgaccaac gaaagtggcc atgggccgcc ttggaatctt ttcggtatca     1980

tcgtttcatg ccctggtggc agcacgcact ggtgaaactg gagtgagaag acgtactcag     2040

gccatgtcca gatccgcgag caagcgaagg agcaggtttt cttctctgtg gggtctggat     2100

actacctcca aaaagaagca gggacggcca agcatcaatc aggtgtttgg agagggaacc     2160

gaagctgtaa agaaatcttt agagggaata tttgatgaca ttgttccaga tggcaagagg     2220

gagaaagaag tggtcttacc taacgttcac cagcacaacc ctgactgcga catttgggtc     2280

cacgagtatt tcactccatc ctggttctgt ctgcccaata atcagcctgc cctgacggtc     2340

gtccggccag gcgacactgc acgggacacc ctggagctga tttgcaagac acatcaactg     2400

gatcattctg ctcattacct gcgcctgaaa tttctaatag aaaacaaaat gcagctctat     2460

gttccacagc ccgaggaaga catctatgag ctgctgtaca aagaaattga aatctgtcca     2520

aaagtcactc agagcatcca cattgagaag tcagatacag ctgctgatac ttacgggttt     2580

tcactttctt ctgtggaaga agatggtatt cgaaggctgt acgtgaatag tgtgaaggaa     2640

accggtttag cttccaagaa aggcctgaaa gcaggagatg agattcttga gatcaataat     2700

cgtgctgctg acgccctgaa ctcttctatg ctcaaagatt tcctctcaca gccctcgctg     2760

ggcctcctgg tgaggaccta ccccgagctg gaggaaggag tggagctgct ggaaagcccg     2820

ccccaccgag tggacggccc tgccgacctt ggcgagagcc ccctcgcctt tctcaccagc     2880

aacccagggc acagcctttg cagcgagcag ggcagcagtg ctgagaccgc tccagaggag     2940

accgaggggc cagacttgga atcctcagat gagactgatc acagcagcaa gagtacagaa     3000

caggtggccg cattttgccg cagtttgcat gagatgaacc cctctgacca gagcccatct     3060

cctcaggact ccacggggcc tcagctggcg accatgagac aactctcgga tgcagataag     3120

ctgcgcaagg tgatctgcga gctcctggag acggagcgca cctacgtgaa ggatttaaac     3180

tgtcttatgg agagatacct aaagcctctt caaaaagaaa cttttctcac ccaggatgag     3240

cttgacgtgc tttttggaaa tttaacggaa atggtagagt ttcaagtaga attccttaaa     3300

actctagaag atggagtgag actggtacct gatttggaaa agcttgagaa ggttgatcaa     3360

tttaagaaag tgctgttctc tctgggggga tcattcctgt attatgctga ccgcttcaag     3420

ctctacagtg ccttctgcgc cagccacaca aaagttccca aggtcctggt gaaagccaag     3480

acagacacgg ctttcaaggc attcttggat gcccagaacc cgaagcagca gcactcatcc     3540

acgctggagt cgtacctcat caagcccatc cagaggatcc tcaagtaccc acttctgctc     3600

agggagctgt tcgccctgac cgatgcggag agcgaggagc actaccacct ggacgtggcc     3660

atcaagacca tgaacaaggt tgccagtcac atcaatgaga tgcagaaaat ccatgaagag     3720

tttggggctg tgtttgacca gctgattgct gaacagactg gtgagaaaaa agaggttgca     3780

gatctgagca tgggagacct gcttttgcac actaccgtga tctggctgaa cccgccggcc     3840

tcgctgggca agtggaaaaa ggaaccagag ttggcagcat tcgtcttcaa aactgctgtg     3900

gtccttgtgt ataaagatgg ttccaaacag aagaagaaac ttgtaggatc tcacaggctt     3960

tccatttatg aggactggga ccccttcaga tttcgacaca tgatccccac ggaagcgctg     4020

caggttcgag ctttggcgag tgcagatgca gaggcaaatg ccgtgtgtga aattgtccat     4080

gtaaaatccg agtctgaagg gaggccggag agggtctttc acttgtgctg cagctcccca     4140

gagagccgaa aggatttcct aaaggctgtg cattcaatcc tgcgtgataa gcacagaaga     4200

cagctcctca aaaccgagag ccttccctca tcccagcaat atgtcccttt tggaggcaaa     4260

agattgtgtg cactgaaggg ggccaggccg gccatgagca gggcagtgtc tgccccaagc     4320

aagtctcttg ggaggaggag gcggcggctg gctcgaaaca ggtttaccat tgattctgat     4380

gccgtctccg caagcagccc ggagaaagag tcccagcagc cccccggtgg tggggacact     4440

gaccgatggg tagaggagca gtttgatctt gctcagtatg aggagcaaga tgacatcaag     4500

gagacagaca tcctcagtga cgatgatgag ttctgtgagt ccgtgaaggg tgcctcagtg     4560

gacagagacc tgcaggagcg gcttcaggcc acctccatca gtcagcggga aagaggccgg     4620

aaaaccctgg atagtcacgc gtcccgcatg gcacagctca agaagcaagc tgccctgtcg     4680

gggatcaatg gaggcctgga gagcgcaagc gaggaagtca tttgggttag gcgtgaagac     4740

tttgccccct ccaggaaact gaacactgag atctga                               4776


<210>  543
<211>  2319
<212>  DNA
<213>  Homo sapiens;

<400>  543
atgtatccgc agggcagaca tccggctccc catcaacccg ggcagccggg atttaaattc       60

acggtggctg agtcttgtga caggatcaaa gacgaattcc agttcctgca agctcagtat      120

cacagcctca aagtggagta cgacaagctg gcaaacgaga agacggagat gcagcgccat      180

tatgtgatgt actatgagat gtcctatggc ttgaacattg aaatgcacaa gcagacagag      240

attgcgaaga gactgaacac aattttagca cagatcatgc ctttcctgtc acaagagcac      300

cagcagcagg tggcgcaggc agtggagcgc gccaagcagg tcaccatgac ggagctgaac      360

gccatcatcg ggcagcagca gctccaggcg cagcacctct cccatgccac acacggcccc      420

ccggtccagt tgccacccca cccgtcaggt ctccagcctc caggaatccc cccagtgaca      480

gggagcagct ccgggctgct ggcactgggc gccctgggca gccaggccca tctgacggtg      540

aaggatgaga agaaccacca tgaactcgat cacagagaga gagaatccag tgcgaataac      600

tctgtgtcac cctcggaaag cctccgggcc agtgagaagc accggggctc tgcggactac      660

agcatggaag ccaagaagcg gaaggcggag gagaaggaca gcttgagccg atacgacagt      720

gatggagaca agagtgatga tctggtggtg gatgtttcca atgaggaccc cgcaacgccc      780

cgggtcagcc cggcacactc ccctcctgaa aatgggctgg acaaggcccg tagcctgaaa      840

aaagatgccc ccaccagccc tgcctcggtg gcctcttcca gtagcacacc ttcctccaag      900

accaaagacc ttggtcataa cgacaaatcc tccacccctg ggctcaagtc caacacacca      960

accccaagga acgacgcccc aactccaggc accagcacga ccccagggct caggtcgatg     1020

ccgggtaaac ctccgggcat ggacccgata ggtataatgg cctcggctct gcgcacgccc     1080

atctccatca ccagctccta tgcggcgccc ttcgccatga tgagccacca tgagatgaac     1140

ggctccctca ccagtcctgg cgcctacgcc ggcctccaca acatcccacc ccagatgagc     1200

gccgccgccg ctgctgcagc cgctgcctat ggccgatcgc caatggtgag ctttggagct     1260

gttggttttg accctcaccc cccgatgcgg gccacaggcc tcccctcaag cctggcctcc     1320

attcctggag gaaaaccagc gtactcattc catgtgagtg ctgatgggca gatgcagccc     1380

gtgcccttcc cccacgacgc cctggcaggc cccggcatcc cgaggcacgc ccggcagatc     1440

aacacactca gccacgggga ggtggtgtgt gccgtgacca tcagcaaccc cacgaggcac     1500

gtctacacag gtggcaaggg ctgcgtgaag atctgggaca tcagccagcc aggcagcaag     1560

agccccatct cccagctgga ctgcctgaac agggacaatt acatccgctc ctgcaagctg     1620

ctccctgatg ggcgcacgct catcgtgggc ggcgaggcca gcacgctcac catctgggac     1680

ctggcctcgc ccacgccccg catcaaggcc gagctgacgt cctcggctcc cgcctgttat     1740

gccctggcca ttagccctga cgccaaagtc tgcttctcct gctgcagcga tgggaacatt     1800

gctgtctggg acctgcacaa ccagaccctg gtcaggcagt tccagggcca cacagatggg     1860

gccagctgca tagacatctc ccatgatggc accaaactgt ggacaggggg cctggacaac     1920

acggtgcgct cctgggacct gcgggagggc cgacagctac agcagcatga cttcacttcc     1980

cagatcttct cgctgggcta ctgccccact ggggagtggc tggctgtggg catggagagc     2040

agcaacgtgg aggtgctgca ccacaccaag cctgacaagt accagctgca cctgcacgag     2100

agctgcgtgc tctccctcaa gttcgcctac tgcggcaagt ggttcgtgag cactgggaaa     2160

gataaccttc tcaacgcctg gaggacgcct tatggagcca gcatattcca gtctaaagaa     2220

tcctcgtctg tcttgagttg tgacatttca gcggatgaca aatacattgt aacaggctct     2280

ggtgacaaga aggccacagt ttatgaggtc atctactaa                            2319


<210>  544
<211>  2322
<212>  DNA
<213>  Homo sapiens;

<400>  544
atgattcgcg acctgagcaa gatgtacccg cagaccagac acccagcacc gcatcagcct       60

gctcaaccct ttaaatttac aatttccgaa tcctgtgatc ggattaagga agagtttcag      120

tttttacagg ctcaatacca cagtctgaag ctggaatgtg agaaactcgc cagtgagaag      180

acagagatgc agcggcatta tgtcatgtat tatgaaatgt cctatgggtt gaatatagaa      240

atgcacaagc aggcagagat tgtcaagagg ctgaatgcta tctgtgcaca agtcattcct      300

ttcctgtccc aagagcacca gcaacaagtg gtgcaggctg tggaacgggc caagcaggtg      360

accatggcag aactgaacgc catcattggg caacaactcc aggcccagca tttatcacat      420

ggacatggtc tccccgtacc tctgactcca cacccttcag ggctccagcc ccctgccatt      480

ccacccatcg gtagcagtgc cgggcttctg gccctctcca gtgctctagg aggtcagtcc      540

catcttccaa ttaaagatga gaagaagcac catgacaatg atcaccaaag agacagagac      600

tccatcaaga gctcttcagt atccccatca gccagtttcc gaggtgctga gaagcacaga      660

aactccgcag actactcctc agagagcaaa aagcagaaaa ctgaagaaaa ggaaattgca      720

gctcgttatg acagcgatgg tgagaaaagt gatgacaact tggtggttga cgtttccaat      780

gaggatccat cttcccctcg agggagccca gcacattccc ccagagagaa tggcctagac      840

aagacacgcc tgctcaagaa agatgccccg attagtccag cctctattgc atcttccagc      900

agtactccct cctccaaatc caaagaactt agccttaatg aaaaatctac tactcccgtc      960

tcaaagtcca atacccctac tccacgaact gatgcgccca ccccaggcag taactctact     1020

cccggattga ggcctgtacc tggaaaacca ccaggagttg accctttggc ctcaagccta     1080

aggaccccaa tggcagtacc ttgtccatat ccaactccat ttgggattgt gccccatgct     1140

ggaatgaacg gagagctgac cagccccgga gcggcctacg ctgggctcca caacatctcc     1200

cctcagatga gcgcagctgc tgccgccgcc gctgctgctg ctgcctatgg gagatcacca     1260

gtggtgggat ttgatccaca ccatcacatg cgtgtgccag caatacctcc aaacctgaca     1320

ggcattccag gaggaaaacc agcatactcc ttccatgtta gcgcagatgg tcagatgcag     1380

cctgtccctt ttccacccga cgccctcatc ggacctggaa tcccccggca tgctcgccag     1440

atcaacaccc tcaaccacgg ggaggtggtg tgcgcggtga ccatcagcaa ccccacgaga     1500

cacgtgtaca cgggtgggaa gggctgcgtc aaggtctggg acatcagcca cccaggcaat     1560

aagagtcctg tctcccagct cgactgtctg aacagggata actacatccg ttcctgcaga     1620

ttgctccctg atggtcgcac cctaattgtt ggaggggaag ccagtacttt gtccatttgg     1680

gacctggcgg ctccaacccc acgcatcaag gcagagctga catcctcggc ccccgcctgc     1740

tatgccctgg ccatcagccc cgattccaag gtctgcttct catgctgcag cgacggcaac     1800

atcgctgtgt gggatctgca caaccagacc ttggtgaggc aattccaggg ccacacagat     1860

ggagccagct gtattgacat ttctaatgat ggcaccaagc tctggacagg tggtttggac     1920

aacacggtca ggtcctggga cctgcgcgag gggcggcagc tgcagcagca cgacttcacc     1980

tcccagatct tttctctggg ctactgccca actggagagt ggcttgcagt ggggatggag     2040

aacagcaatg tggaagtttt gcatgtcacc aagccagaca aataccaact acatcttcat     2100

gagagctgtg tgctgtcgct caagtttgcc cattgtggca aatggtttgt aagcactgga     2160

aaggacaacc ttctgaatgc ctggagaaca ccttatgggg ccagtatatt ccagtccaaa     2220

gaatcctcat cggtgcttag ctgtgacatc tccgtggacg acaaatacat tgtcactggc     2280

tctggggata agaaggccac agtttatgaa gttatttatt aa                        2322


<210>  545
<211>  2355
<212>  DNA
<213>  Homo sapiens;

<400>  545
atgccacata ctttgtggat ggtgtgggtc ttgggggtca tcatcagcct ctccaaggaa       60

gaatcctcca atcaggcttc tctgtcttgt gaccgcaatg gtatctgcaa gggcagctca      120

ggatctttaa actccattcc ctcagggctc acagaagctg taaaaagcct tgacctgtcc      180

aacaacagga tcacctacat tagcaacagt gacctacaga ggtgtgtgaa cctccaggct      240

ctggtgctga catccaatgg aattaacaca atagaggaag attctttttc ttccctgggc      300

agtcttgaac atttagactt atcctataat tacttatcta atttatcgtc ttcctggttc      360

aagccccttt cttctttaac attcttaaac ttactgggaa atccttacaa aaccctaggg      420

gaaacatctc ttttttctca tctcacaaaa ttgcaaatcc tgagagtggg aaatatggac      480

accttcacta agattcaaag aaaagatttt gctggactta ccttccttga ggaacttgag      540

attgatgctt cagatctaca gagctatgag ccaaaaagtt tgaagtcaat tcagaatgta      600

agtcatctga tccttcatat gaagcagcat attttactgc tggagatttt tgtagatgtt      660

acaagttccg tggaatgttt ggaactgcga gatactgatt tggacacttt ccatttttca      720

gaactatcca ctggtgaaac aaattcattg attaaaaagt ttacatttag aaatgtgaaa      780

atcaccgatg aaagtttgtt tcaggttatg aaacttttga atcagatttc tggattgtta      840

gaattagagt ttgatgactg tacccttaat ggagttggta attttagagc atctgataat      900

gacagagtta tagatccagg taaagtggaa acgttaacaa tccggaggct gcatattcca      960

aggttttact tattttatga tctgagcact ttatattcac ttacagaaag agttaaaaga     1020

atcacagtag aaaacagtaa agtttttctg gttccttgtt tactttcaca acatttaaaa     1080

tcattagaat acttggatct cagtgaaaat ttgatggttg aagaatactt gaaaaattca     1140

gcctgtgagg atgcctggcc ctctctacaa actttaattt taaggcaaaa tcatttggca     1200

tcattggaaa aaaccggaga gactttgctc actctgaaaa acttgactaa cattgatatc     1260

agtaagaata gttttcattc tatgcctgaa acttgtcagt ggccagaaaa gatgaaatat     1320

ttgaacttat ccagcacacg aatacacagt gtaacaggct gcattcccaa gacactggaa     1380

attttagatg ttagcaacaa caatctcaat ttattttctt tgaatttgcc gcaactcaaa     1440

gaactttata tttccagaaa taagttgatg actctaccag atgcctccct cttacccatg     1500

ttactagtat tgaaaatcag taggaatgca ataactacgt tttctaagga gcaacttgac     1560

tcatttcaca cactgaagac tttggaagct ggtggcaata acttcatttg ctcctgtgaa     1620

ttcctctcct tcactcagga gcagcaagca ctggccaaag tcttgattga ttggccagca     1680

aattacctgt gtgactctcc atcccatgtg cgtggccagc aggttcagga tgtccgcctc     1740

tcggtgtcgg aatgtcacag gacagcactg gtgtctggca tgtgctgtgc tctgttcctg     1800

ctgatcctgc tcacgggggt cctgtgccac cgtttccatg gcctgtggta tatgaaaatg     1860

atgtgggcct ggctccaggc caaaaggaag cccaggaaag ctcccagcag gaacatctgc     1920

tatgatgcat ttgtttctta cagtgagcgg gatgcctact gggtggagaa ccttatggtc     1980

caggagctgg agaacttcaa tccccccttc aagttgtgtc ttcataagcg ggacttcatt     2040

cctggcaagt ggatcattga caatatcatt gactccattg aaaagagcca caaaactgtc     2100

tttgtgcttt ctgaaaactt tgtgaagagt gagtggtgca agtatgaact ggacttctcc     2160

catttccgtc tttttgatga gaacaatgat gctgccattc tcattcttct ggagcccatt     2220

gagaaaaaag ccattcccca gcgcttctgc aagctgcgga agataatgaa caccaagacc     2280

tacctggagt ggcccatgga cgaggctcag cgggaaggat tttgggtaaa tctgagagct     2340

gcgataaagt cctag                                                      2355


<210>  546
<211>  666
<212>  DNA
<213>  Homo sapiens;

<400>  546
atggcgggag gggtgctccc gctgaggggc ctccgcgcct tgtgtcgcgt gctgctcttc       60

ctctcgcagt tctgcattct gtcgggcggt gaaagtactg aaatcccacc ttatgtgatg      120

aagtgtccga gcaatggttt gtgtagcagg cttcctgcag actgtataga ctgcacaaca      180

aatttctcct gtacctatgg gaagcctgtc acttttgact gtgcagtgaa accatctgtt      240

acctgtgttg atcaagactt caaatcccaa aagaacttca tcattaacat gacttgcaga      300

ttttgctggc agcttcctga aacagattac gagtgtacca actccaccag ctgcatgacg      360

gtgtcctgtc ctcggcagcg ctaccctgcc aactgcacgg tgcgggacca cgtccactgc      420

ttgggtaacc gtacttttcc caaaatgcta tattgcaatt ggactggagg ctataagtgg      480

tctacggctc tggctctaag catcaccctc ggtgggtttg gagcagaccg tttctacctg      540

ggccagtggc gggaaggcct cggcaagctc ttcagcttcg gtggcctggg aatatggacg      600

ctgatagacg tcctgctcat tggagttggc tatgttggac cagcagatgg ctctttgtac      660

atttag                                                                 666


<210>  547
<211>  936
<212>  DNA
<213>  Homo sapiens;

<400>  547
atgtccaacc ccagcgcccc accaccatat gaagaccgca accccctgta cccaggccct       60

ccgccccctg ggggctatgg gcagccatct gtcctgccag gagggtatcc tgcctaccct      120

ggctacccgc agcctggcta cggtcaccct gctggctacc cacagcccat gccccccacc      180

cacccgatgc ccatgaacta cggcccaggc catggctatg atggggagga gagagcagtg      240

agtgatagct tcgggcctgg agagtgggat gaccggaaag tgcgacacac ttttatccga      300

aaggtttact ccatcatctc cgtgcagctg ctcatcactg tggccatcat tgctatcttc      360

acctttgtgg aacctgtcag cgcctttgtg aggagaaatg tggctgtcta ctacgtgtcc      420

tatgctgtct tcgttgtcac ctacctgatc cttgcctgct gccagggacc cagacgccgt      480

ttcccatgga acatcattct gctgaccctt tttacttttg ccatgggctt catgacgggc      540

accatttcca gtatgtacca aaccaaagcc gtcatcattg caatgatcat cactgcggtg      600

gtatccattt cagtcaccat cttctgcttt cagaccaagg tggacttcac ctcgtgcaca      660

ggcctcttct gtgtcctggg aattgtgctc ctggtgactg ggattgtcac tagcattgtg      720

ctctacttcc aatacgttta ctggctccac atgctctatg ctgctctggg ggccatttgt      780

ttcaccctgt tcctggctta cgacacacag ctggtcctgg ggaaccggaa gcacaccatc      840

agccccgagg actacatcac tggcgccctg cagatttaca cagacatcat ctacatcttc      900

acctttgtgc tgcagctgat gggggatcgc aattaa                                936


<210>  548
<211>  717
<212>  DNA
<213>  Homo sapiens;

<400>  548
atgtacgccc ccggaggcgc agggctgccc ggcgggcgcc ggcggaggag cccgggaggc       60

agcgctctgc ccaagcagcc ggagcgtagc ctggcctcgg ccctgcctgg cgccctgtct      120

atcacggcgc tgtgcactgc cctcgccgag cccgcctggt tgcacatcca cggaggcacc      180

tgttcgcgcc aggagctggg ggtctccgac gtgttgggct atgtgcaccc ggacctgctg      240

aaagatttct gcatgaatcc ccagacagtg ctgctcctgc gggtcatcgc cgccttctgt      300

ttcctgggca tcctgtgtag tctctccgct ttccttctgg atgtctttgg gccgaagcat      360

cctgctctga agatcactcg tcgctatgcc ttcgcccata tcctaacggt tctgcagtgt      420

gccaccgtca ttggcttttc ttattgggct tctgaactca tcttggccca gcagcagcag      480

cataagaagt accatggatc ccaggtctat gtcaccttcg ccgttagctt ctacctggtg      540

gcaggagctg gtggagcctc aatcctggcc acggcagcca acctcctgcg ccactacccc      600

acagaggaag aggagcaggc gctggagctg ctctcagaga tggaagagaa cgagccctac      660

ccggcggaat atgaggtcat caaccagttc cagccacccc ctgcttacac accctaa         717


<210>  549
<211>  681
<212>  DNA
<213>  Homo sapiens;

<400>  549
atgaccgtgc agagactcgt ggccgcggcc gtgctggtgg ccctggtctc actcatcctc       60

aacaacgtgg cggccttcac ctccaactgg gtgtgccaga cgctggagga tgggcgcagg      120

cgcagcgtgg ggctgtggag gtcctgctgg ctggtggaca ggacccgggg agggccgagc      180

cctggggcca gagccggcca ggtggacgca catgactgtg aggcgctggg ctggggctcc      240

gaggcagccg gcttccagga gtcccgaggc accgtcaaac tgcagttcga catgatgcgc      300

gcctgcaacc tggtggccac ggccgcgctc accgcaggcc agctcacctt cctcctgggg      360

ctggtgggcc tgcccctgct gtcacccgac gccccgtgct gggaggaggc catggccgct      420

gcattccaac tggcgagttt tgtcctggtc atcgggctcg tgactttcta cagaattggc      480

ccatacacca acctgtcctg gtcctgctac ctgaacattg gcgcctgcct tctggccacg      540

ctggcggcag ccatgctcat ctggaacatt ctccacaaga gggaggactg catggccccc      600

cgggtgattg tcatcagccg ctccctgaca gcgcgctttc gccgtgggct ggacaatgac      660

tacgtggagt caccatgctg a                                                681


<210>  550
<211>  1368
<212>  DNA
<213>  Homo sapiens;

<400>  550
atgggcctct ccaccgtgcc tgacctgctg ctgccactgg tgctcctgga gctgttggtg       60

ggaatatacc cctcaggggt tattggactg gtccctcacc taggggacag ggagaagaga      120

gatagtgtgt gtccccaagg aaaatatatc caccctcaaa ataattcgat ttgctgtacc      180

aagtgccaca aaggaaccta cttgtacaat gactgtccag gcccggggca ggatacggac      240

tgcagggagt gtgagagcgg ctccttcacc gcttcagaaa accacctcag acactgcctc      300

agctgctcca aatgccgaaa ggaaatgggt caggtggaga tctcttcttg cacagtggac      360

cgggacaccg tgtgtggctg caggaagaac cagtaccggc attattggag tgaaaacctt      420

ttccagtgct tcaattgcag cctctgcctc aatgggaccg tgcacctctc ctgccaggag      480

aaacagaaca ccgtgtgcac ctgccatgca ggtttctttc taagagaaaa cgagtgtgtc      540

tcctgtagta actgtaagaa aagcctggag tgcacgaagt tgtgcctacc ccagattgag      600

aatgttaagg gcactgagga ctcaggcacc acagtgctgt tgcccctggt cattttcttt      660

ggtctttgcc ttttatccct cctcttcatt ggtttaatgt atcgctacca acggtggaag      720

tccaagctct actccattgt ttgtgggaaa tcgacacctg aaaaagaggg ggagcttgaa      780

ggaactacta ctaagcccct ggccccaaac ccaagcttca gtcccactcc aggcttcacc      840

cccaccctgg gcttcagtcc cgtgcccagt tccaccttca cctccagctc cacctatacc      900

cccggtgact gtcccaactt tgcggctccc cgcagagagg tggcaccacc ctatcagggg      960

gctgacccca tccttgcgac agccctcgcc tccgacccca tccccaaccc ccttcagaag     1020

tgggaggaca gcgcccacaa gccacagagc ctagacactg atgaccccgc gacgctgtac     1080

gccgtggtgg agaacgtgcc cccgttgcgc tggaaggaat tcgtgcggcg cctagggctg     1140

agcgaccacg agatcgatcg gctggagctg cagaacgggc gctgcctgcg cgaggcgcaa     1200

tacagcatgc tggcgacctg gaggcggcgc acgccgcggc gcgaggccac gctggagctg     1260

ctgggacgcg tgctccgcga catggacctg ctgggctgcc tggaggacat cgaggaggcg     1320

ctttgcggcc ccgccgccct cccgcccgcg cccagtcttc tcagatga                  1368


<210>  551
<211>  753
<212>  DNA
<213>  Homo sapiens;

<400>  551
atgccagcct catctccttt cttgctagcc cccaaagggc ctccaggcaa catggggggc       60

ccagtcagag agccggcact ctcagttgcc ctctggttga gttggggggc agctctgggg      120

gccgtggctt gtgccatggc tctgctgacc caacaaacag agctgcagag cctcaggaga      180

gaggtgagcc ggctgcaggg gacaggaggc ccctcccaga atggggaagg gtatccctgg      240

cagagtctcc cggagcagag ttccgatgcc ctggaagcct gggagaatgg ggagagatcc      300

cggaaaagga gagcagtgct cacccaaaaa cagaagaagc agcactctgt cctgcacctg      360

gttcccatta acgccacctc caaggatgac tccgatgtga cagaggtgat gtggcaacca      420

gctcttaggc gtgggagagg cctacaggcc caaggatatg gtgtccgaat ccaggatgct      480

ggagtttatc tgctgtatag ccaggtcctg tttcaagacg tgactttcac catgggtcag      540

gtggtgtctc gagaaggcca aggaaggcag gagactctat tccgatgtat aagaagtatg      600

ccctcccacc cggaccgggc ctacaacagc tgctatagcg caggtgtctt ccatttacac      660

caaggggata ttctgagtgt cataattccc cgggcaaggg cgaaacttaa cctctctcca      720

catggaacct tcctggggtt tgtgaaactg tga                                   753


<210>  552
<211>  1911
<212>  DNA
<213>  Homo sapiens;

<400>  552
atggaaggga gaggaccgta ccggatctac gaccctgggg gcagcgtgcc ctcaggagag       60

gcatccgcag cttttgagcg cctagtgaag gagaattccc ggctgaagga aaaaatgcaa      120

gggataaaga tgttagggga gcttttggaa gagtcccaga tggaagcgac caggctccgg      180

cagaaggcag aggagctagt gaaggacaac gagctgctcc caccaccttc tccctccttg      240

ggctccttcg accccctggc tgagctcaca ggaaaggact caaatgtcac agcatctccc      300

acagcccctg catgccccag tgacaagcca gcaccagtcc agaagcctcc atccagtggc      360

acctcctctg aatttgaagt ggtcactcct gaggagcaga attcaccaga gagcagcagc      420

catgccaatg cgatggcgct gggccccctg ccccgtgagg acggcaacct gatgctgcac      480

ctgcagcgcc tggagaccac gctgagtgtg tgtgccgagg agccggacca cggccagctc      540

ttcacccacc tgggccgcat ggccctggag ttcaaccgac tggcatccaa ggtgcacaag      600

aatgagcagc gcacctccat tctgcagacc ctgtgtgagc agcttcggaa ggagaacgag      660

gctctgaagg ccaagttgga taagggcctg gaacagcggg atcaggctgc cgagaggctg      720

cgggaggaaa atttggagct caagaagttg ttgatgagca atggcaacaa agagggtgcg      780

tctgggcggc caggctcacc gaagatggaa gggacaggca agaaggcagt ggctggacag      840

cagcaggcta gtgtgacggc aggtaaggtc ccagaggtgg tggccttggg cgcagccgag      900

aagaaggtga agatgctgga gcagcagcgc agtgagctgc tggaagtgaa caagcagtgg      960

gaccagcatt tccggtccat gaagcagcag tatgagcaga agatcactga gctgcgtcag     1020

aagctggctg atttgcagaa gcaggtgact gacctggagg ccgagcggga gcagaagcag     1080

cgtgactttg accgcaagct cctcctggcc aagtccaaga ttgaaatgga ggagaccgac     1140

aaggagcagc tgacagcaga ggccaaggag ctgcgccaaa aggtcaagta cctgcaggat     1200

cagctgagcc cactcacccg acagcgtgag taccaggaaa aggagatcca gcggctcaac     1260

aaggccctgg aggaagcact gagcatccaa accccgccat catctccacc aacagcattt     1320

gggagcccag aaggagcagg ggccctccta aggaaacagg agctggtcac gcagaatgag     1380

ttgctgaaac agcaggtgaa gatcttcgag gaggacttcc agagggagcg cagtgatcgt     1440

gagcgcatga atgaggagaa ggaagagctg aagaagcaag tggagaagct gcaggcccag     1500

gtcaccctgt caaatgccca gctaaaagca ttcaaagatg aggagaaggc aagagaagcc     1560

ctcagacagc agaagaggaa agcaaaggcc tcaggagagc gttaccatgt ggagccccac     1620

ccagaacatc tctgcggggc ctacccctac gcctacccgc ccatgccagc catggtgcca     1680

caccatggct tcgaggactg gtcccagatc cgctaccccc ctccccccat ggccatggag     1740

cacccgcccc cactccccaa ctcgcgcctc ttccatctgc cggaatacac ctggcgtcta     1800

ccctgtggag gggttcgaaa tccaaatcag agctcccaag tgatggaccc tcccacagcc     1860

aggcctacag aaccagagtc tccaaaaaat gaccgtgagg ggcctcagtg a              1911


<210>  553
<211>  3117
<212>  DNA
<213>  Homo sapiens;

<400>  553
atgcagccag aggagggcac aggctggctg ctggagctgc tgtccgaggt gcagctgcaa       60

cagtacttcc tgcggctccg agatgacctc aacgtcaccc gcctgtccca ctttgagtac      120

gtcaagaatg aggacctgga gaagatcggc atgggtcggc ctggccagcg gcggctgtgg      180

gaggctgtga agaggaggaa ggccttgtgc aaacgcaagt cgtggatgag taaggtgttc      240

agtggaaagc gactggaggc tgagttccca cctcatcact ctcagagcac cttccggaag      300

acctcgcccg cccctggggg cccagcaggg gaggggcccc tgcagagcct cacctgcctc      360

attggggaga aggacctgcg cctcctggag aagctgggtg atggttcctt tggcgtggtg      420

cgcaggggcg agtgggacgc gccctcaggg aagacggtga gtgtggctgt gaagtgcctg      480

aagcccgatg tcctgagcca gccagaagcc atggacgact tcatccggga ggtcaatgcc      540

atgcactcgc tcgaccaccg aaacctcatc cgcctctacg gggtggtgct cacgccgccc      600

atgaagatgg tgacagagct ggcacctctg ggatcgttgt tggaccggct acgtaagcac      660

cagggccact tcctcctggg gactctgagc cgctacgctg tgcaggtggc tgagggcatg      720

ggctacctgg agtccaagcg ctttattcac cgtgacctgg ctgcccgcaa tctgctgttg      780

gctacccgcg acctggtcaa gatcggggac tttgggctga tgcgagcact acctcagaat      840

gacgaccatt acgtcatgca ggaacatcgc aaggtgccct tcgcctggtg tgcccccgag      900

agcctgaaga cacgcacctt ctcccatgcc agcgacacct ggatgttcgg ggtgacactg      960

tgggaaatgt tcacctacgg ccaggagccc tggatcggcc tcaacggcag tcagatcctg     1020

cataagatcg acaaggaggg ggagcggctg ccccggcccg aggactgtcc ccaggacatc     1080

tacaacgtca tggtccagtg ctgggctcac aagccagagg acagacccac gtttgtggcc     1140

ctgcgggact tcctgctgga ggcccagccc acagacatgc gggcccttca ggactttgag     1200

gaaccggaca agctgcacat ccagatgaat gatgtcatca ccgtcatcga gggaagggcc     1260

gagaactact ggtggcgtgg ccagaacaca cggacgctgt gtgtggggcc cttccctcgc     1320

aacgtggtga cctccgtggc cggcctgtcg gcccaggaca tcagccagcc cctgcagaac     1380

agcttcatcc acacagggca tggcgacagt gacccccgcc actgctgggg cttcccggac     1440

aggattgacg aactgtatct gggaaacccc atggaccccc ccgacctcct gagcgtggaa     1500

ctgagcacct cccggccccc ccagcatcta ggaggggtga aaaaaccaac ctatgaccct     1560

gtgagcgagg accaagaccc cttgtccagc gacttcaaga ggctgggcct gcggaagcca     1620

ggcctgcccc gagggctgtg gctggcgaag ccctcggcgc gggtgccggg caccaaggcc     1680

agccgaggca gcggggctga ggtcacgctc atcgacttcg gtgaggagcc cgtggtcccg     1740

gccctacggc cctgcgcgcc ctccctggcg cagctggcca tggacgcctg ctccctgctg     1800

gacgagaccc cgcctcagag ccccacgcgg gcactgcccc ggcccctgca ccccacgcct     1860

gtggtggact gggacgcacg cccgctgccc cccccgcccg cctatgacga cgtggcccag     1920

gatgaggatg actttgagat ctgctccatc aacagcaccc tcgtgggcgc gggggtccct     1980

gccgggccca gccagggcca gaccaactac gcctttgtgc ctgagcaggc gcggccgccc     2040

cctcccctgg aggacaacct gttcctcccg ccccagggtg ggggcaagcc gcccagctcc     2100

gcacagaccg cagagatctt ccaggcgcta cagcaggagt gcatgaggca actgcaggct     2160

ccggccggct ccccggcccc ctctcccagc ccggggggtg acgacaagcc ccaggtgcct     2220

cctcgggtac ccatcccccc tcggcccacg cgcccacacg tccagctgtc tccagccccc     2280

ccgggcgagg aggagaccag ccagtggcct ggacctgctt cccctccccg ggtgcctccg     2340

cgggagcccc tgtcccctca aggctcgagg acacccagcc ccctggtacc acctggcagc     2400

tccccgctgc caccccggct ctcaagctca cctgggaaga ccatgcccac cacccagagc     2460

tttgcctcag accccaagta cgccaccccc caggtgatcc aggcccctgg cccgcgggct     2520

ggtccctgca tcctgcccat cgtccgggat ggcaagaagg tcagcagcac ccactattac     2580

ttgctgcccg agcgaccatc ctacctggag cgctaccagc gcttcctgcg tgaggcccag     2640

agccccgagg agcctacccc cctgcctgtg cctctgctgc tgcccccacc cagcacccca     2700

gcccccgccg cccccacggc caccgtgcgg ccgatgcccc aggctgcctt ggaccccaag     2760

gccaacttct ccaccaacaa cagcaaccca ggggcccggc caccaccccc gagggccact     2820

gctcggctgc cacagagggg ctgccctggc gatgggccag aggcgggccg gccagcagac     2880

aagatccaga tggccatggt gcatggggtg accacagagg agtgccaggc ggccctgcag     2940

tgccacggct ggagcgtgca gagggctgcc cagtatctga aggtggagca gctcttcggg     3000

ctgggtctgc ggcccagagg ggagtgccac aaagtgctgg agatgttcga ctggaacctg     3060

gagcaggccg gctgccacct tctgggctcc tggggccctg cccaccacaa gcgctga        3117


<210>  554
<211>  5172
<212>  DNA
<213>  Homo sapiens;

<400>  554
atgagagaga aggagcaaga aagggaagaa cagttaatgg aagacaagaa aaggaagaaa       60

gaggataaaa agaaaaaaga agccactcag aaggtcacgg aacaaaaaac caaagtgccc      120

gaagtgacga aaccaagttt aagccaacca acggccgcca gcccaattgg cagctctcca      180

tcgccaccag tcaatggtgg caacaatgcc aaaagggtgg cagtgccgaa cggacaaccg      240

ccaagcgccg cccgctacat gcctcgggag gtgccgccgc gattccgttg ccagcaggac      300

cacaaagtgt tactaaaacg tgggcagccc cctccaccgt cctgcatgct ccttgggggt      360

ggggcagggc ctcctccctg cacagcacct ggagcaaacc caaacaacgc acaagtgaca      420

ggagcgctgc tgcagagtga gagtgggact gcgccagact caacccttgg aggtgctgct      480

gcttcaaatt atgcaaattc cacttggggc tcgggagcct cctccaacaa cggcacctcc      540

cccaacccaa ttcacatctg ggacaaggtg attgtagacg ggtctgacat ggaagagtgg      600

ccttgtattg ccagcaaaga cactgaatct tcttccgaaa acaccaccga taacaacagt      660

gcctcgaacc ctggctctga gaagagcact ctgccaggaa gcaccactag taacaaagga      720

aaagggagcc agtgccagtc tgcaagttct gggaacgaat gtaatcttgg ggtctggaaa      780

tctgacccta aggctaaatc tgttcaatct tccaactcta ctacagagaa caacaatgga      840

ctaggaaatt ggaggaatgt gagtggtcag gatagaattg gacctggctc tggcttcagc      900

aactttaacc caaatagcaa cccatctgcc tggccagcac tggtccaaga aggaacttct      960

aggaaagggg cattggaaac agataatagt aattccagtg cacaggttag cacagtaggt     1020

cagacatcca gggaacagca gtcaaagatg gaaaatgcgg gtgttaattt tgttgtctct     1080

ggcagagaac aggctcaaat tcataacact gatggaccaa aaaatggaaa cactaactcc     1140

ttgaacttaa gttcaccaaa ccccatggag aataagggaa tgccctttgg aatgggcttg     1200

gggaacacct ccaggagcac tgatgcccct tcacaaagca ctggagatcg aaagactggg     1260

agtgttggat cttggggtgc agctaggggg ccttctggaa ctgacacagt ctctggacaa     1320

agcaattctg gaaacaatgg gaacaatgga aaagagagag aggactcctg gaaaggagct     1380

tctgttcaga aatcaactgg gtcaaaaaat gactcttggg acaacaataa caggtctacg     1440

ggtgggtcct ggaactttgg cccccaggac tctaatgaca acaaatgggg tgaagggaac     1500

aaaatgacat ctggggtctc tcagggagaa tggaaacagc cgactgggtc tgatgagttg     1560

aaaattggag aatggagtgg tccaaaccaa ccaaattcta gcactggagc atgggacaat     1620

caaaagggcc accccctccc tgaaaaccaa ggcaatgccc aggctccctg ttggggaaga     1680

tcttccagct ccacaggaag tgaagttgga ggtcaaagca ctggaagcaa ccacaaagca     1740

ggaagtagtg acagtcataa ctctggccgt cggtcgtaca ggcccacaca tcctgattgt     1800

caggctgtct tgcagactct tttgagccga actgatttgg accccagggt gctctcaaac     1860

actggctggg gccaaactca aattaagcag gacacagtgt gggacattga agaggtgcca     1920

aggcctgagg ggaaatctga caaaggaact gaggggtggg agagcgctgc cacacagacc     1980

aagaactcag ggggctgggg agatgcaccc agccaaagca atcaaatgaa gtctggatgg     2040

ggggagctct cagcctctac agagtggaaa gaccccaaga acacaggagg ctggaatgac     2100

tacaagaaca acaactcttc caactgggga ggaggacgac ctgatgaaaa gacaccttcc     2160

tcttggaatg agaatcccag caaggatcag gggtggggag gtggacgcca gcccaatcaa     2220

ggatggtctt ctggaaagaa tggttggggg gaggaagtcg atcagacaaa aaacagcaat     2280

tgggaaagtt ctgcaagtaa acctgtgtct gggtggggtg aaggagggca gaatgaaatc     2340

gggacttggg gtaatggtgg caatgcaagc ctagcttcaa aaggtgggtg ggaggattgc     2400

aaaagatccc cagcatggaa tgagacgggc cgacagccca attcctggaa taaacaacac     2460

caacagcagc agcccccaca gcagccgccg ccaccacaac cagaggcttc tggttcgtgg     2520

ggaggcccac ccccaccacc tccaggcaac gttcgacctt ccaattccag ctggagcagc     2580

gggccacagc ctgcaacacc taaggatgag gaacccagtg gttgggaaga gccatcccca     2640

cagtcaatta gtcggaaaat ggacattgat gatggcactt cagcatgggg agaccctaac     2700

agttataact acaagaatgt gaatctgtgg gataagaatt cccaaggggg cccagcacct     2760

cgagaaccaa acctgcccac cccaatgacc agtaaatcgg catcagattc caaatctatg     2820

caagacggct ggggggagag tgacgggcca gtcacaggag ctcgccatcc cagctgggaa     2880

gaggaggagg atggaggagt ctggaacacc actggctctc agggcagtgc ttcctcccac     2940

aactcagcaa gctggggaca aggaggaaag aaacaaatga agtgctcact caaaggagga     3000

aacaatgatt catggatgaa tcctcttgcc aaacagtttt caaatatggg attgctgagt     3060

cagactgaag ataatccaag cagcaaaatg gatttgtctg taggaagcct ttcagataaa     3120

aaatttgatg tggacaagcg agcgatgaat ctcggggatt ttaatgatat catgaggaag     3180

gatcgatctg ggttccgtcc acctaattcc aaagacatgg gaaccacaga tagtgggcct     3240

tattttgaga agggcggtag tcatggtttg tttggaaaca gcacagcaca atcgagaggt     3300

ctgcacacac ccgtgcagcc actaaattct tctcccagtc tccgggcgca agtgcctccc     3360

cagtttattt ccccccaggt ttctgcctca atgctcaagc agtttcccaa cagtggcctg     3420

agtccaggtc ttttcaatgt ggggccccag ttatctcctc aacaaattgc catgctgagc     3480

cagcttccac aaattcccca gtttcagttg gcatgtcagc ttctcttgca gcagcagcaa     3540

cagcagcagt tgttacagaa ccagagaaag atttctcaag ctgtacgcca acagcaagag     3600

cagcagctgg ctcgaatggt gagtgcactg cagcagcagc agcagcagca gcagaggcag     3660

ccaggcatga agcactcgcc ctctcatcct gttgggccca agccgcatct ggacaacatg     3720

gtacccaacg cattgaatgt ggggctccca gaccttcaaa ccaaagggcc aatacctgga     3780

tatggttctg gcttcagctc tggcggcatg gactatggca tggttggtgg gaaggaggct     3840

ggaaccgagt ctcgctttaa acagtggacc tccatgatgg aggggctgcc ctctgtagcc     3900

acacaggaag ccaatatgca caaaaatggc gctatagtgg cccctggtaa aacccgggga     3960

gggtcaccgt acaaccagtt tgatatcatc cctggtgaca cactgggtgg ccatacgggt     4020

cctgctggtg atagctggtt acctgccaaa tctccaccaa caaataaaat cggaagtaaa     4080

tccagcaatg ccagttggcc tccagaattc caaccaggag tgccatggaa aggtatccaa     4140

aacattgacc ctgaatctga cccctatgtc accccaggaa gtgtgctggg gggtacagcc     4200

acatctccca ttgtagatac tgaccaccaa ctgctgcggg ataacaccac agggtctaat     4260

tcttccctca acacctcgct gccttcacct ggtgcctggc cctacagtgc ctctgacaac     4320

tcctttacca acgttcatag cacttcagca aagttccctg attacaaatc aacatggtcc     4380

ccagatccca taggacacaa ccccactcat ctctccaaca agatgtggaa aaaccatatt     4440

tcctccagga acactacacc gctgccccgc ccacctcctg gtctgaccaa ccccaaacca     4500

tcatctccct ggagcagcac agcaccccga tcagtcaggg ggtgggggac acaggactca     4560

cggctcgcct cggcctctac ctggagtgat ggtggctcag ttcgtcctag ttactggctg     4620

gttcttcaca atctcacccc acagattgat gggtcaacct tgagaacgat ctgcatgcag     4680

catggcccac tgctgacatt ccatctgaat ctaacccagg gcactgccct gatccgatac     4740

agcaccaaac aggaggcggc caaggcccaa actgcactgc acatgtgtgt gttgggaaac     4800

actaccatcc ttgctgagtt tgccactgat gatgaagtca gccgctttct ggcacaagct     4860

cagcccccta cacctgcagc aaccccaagt gcgccagctg cggggtggca gtcgctggag     4920

accggccaga accagtcaga tcccgtggga cctgctctga atctttttgg tgggtccact     4980

gggctcgggc agtggagcag cagcgctggt ggcagcagcg gggccgatct tgctggcgct     5040

tcattgtggg ggcccccaaa ctattcttct agcttatggg gagtcccaac ggtggaagat     5100

ccccatagga tgggcagccc tgctccttta ctacctggtg accttctggg aggagggtcg     5160

gattcaatct ga                                                         5172


<210>  555
<211>  3138
<212>  DNA
<213>  Homo sapiens;

<400>  555
atggggtcgc agccgccgct ggggtctccg ctgtctcgcg aggagggtga agcgcccccg       60

cctgctcccg cttcggaggg taggcggaga agtcgccggg tacgccttcg cggatcctgc      120

cgacaccgac ctagctttct gggctgccgg gagctcgcgg cgagcgcccc agccaggcct      180

gcgccggcat cctccgagat aatggcatca gctgctaagg aatttaaaat ggacaacttt      240

tcacctaaag ctggcactag caaattgcaa cagacagtac cagctgatgc atctcctgat      300

tctaagtgtc ctatatgctt ggatagattt gataatgtgt cttacttaga tcgctgctta      360

cataagttct gttttcgctg tgtacaggag tggtcaaaaa acaaagctga atgcccacta      420

tgtaaacagc cctttgattc tattttccat tctgtgaggg cagaagatga cttcaaggag      480

tatgtcctaa ggccttcgta taatggttct tttgtcaccc ctgatcgacg atttcgctac      540

cgtacaactc tgacaaggga acgaaatgct tctgtgtatt cacctagtgg tcctgtgaac      600

agaagaacaa caactccacc ggatagtgga gtactgtttg aagggttagg catttcaaca      660

agacctagag atgttgaaat tcctcagttt atgagacaga ttgcagtaag gaggccaact      720

acggcagatg aaagatcttt gcggaaaatt caagaacaag atattattaa ttttagacga      780

actctttatc gtgctggtgc tcgagttaga aatattgaag atggtggccg ctacagggat      840

atttcagctg aatttttccg tagaaatcca gcttgccttc acagattagt cccctggtta      900

aaacgtgaac ttacagttct ttttggagct catggatctt tagtgaatat tgtccagcat      960

attatcatga gtaatgttac tcgctatgac ttggagagtc aggcatttgt gtctgattta     1020

agaccatttt tacttaatcg aactgagcat tttatacatg aatttatcag ttttgcccga     1080

tctcctttta acatggcagc ctttgaccag catgccaatt atgattgccc tgctccttca     1140

tacgaagaag gcagccattc tgattcttca gtcataacaa tatctccaga tgaggctgag     1200

acccaagagc tggatattaa tgtagccact gttagtcagg caccatggga tgatgaaact     1260

ccaggaccat cttactcaag ctcagagcag gtacacgtta ctatgtcttc tcttttaaat     1320

acttctgaca gttcagatga agaacttgtc acaggaggag ccacgtctca gatacaagga     1380

gtacaaacca atgacgacct aaataatgac agtgatgatt cttcagataa ttgtgtcatt     1440

gttgggtttg ttaaaccact agctgagagg accccagaac ttgttgaact gtcctctgat     1500

tctgaggact taggttctta tgagaaaatg gagacagtga agacacaaga acaggagcaa     1560

tcttacagtt ctggtgatag cgatgttagt agatgctcat ctccacactc tgtccttgga     1620

aaggatgaac aaataaataa aggtcattgt gattctagta caagaatcaa atcaaagaag     1680

gaagagaaac gatctacatc attgtcatct cccagaaacc tgaactcatc tgtaagagga     1740

gacagagtat attctccata taaccataga cacagaaaga ggggaagatc aagaagttca     1800

gattcacgtt ctcagagtag aagtgggcat gatcagaaga atcatagaaa gcatcatggg     1860

aagaaaagaa tgaaaagtaa acgatccaga agcagggaaa gtagcagacc tagagggaga     1920

agagacaaaa agagatcaag aactagagat agcagttggt ccagaagaag ccaaactctg     1980

tctctaagta gtgaaagcac aagcagatca aggtctcgta gcagtgatca tggtaaaaga     2040

agatcacgga gcagaaatag agatcgttat tatttaagaa ataattatgg aagcagatac     2100

aaatgggagt atacttatta cagtagaaac aaggacaggg atgggtacga atcatcttac     2160

aggaggagga ctctgtccag agctcattat tctagacagt cttcaagtcc agaatttaga     2220

gttcagtcct tttctgaaag aacaaatgct aggaaaaaaa ataatcacag tgagaggaag     2280

tattactact atgaaaggca cagatcaagg agcctgtcta gtaacagatc aaggactgca     2340

tctaccggga ctgaccgggt gagaaatgaa aagcctggag ggaaacgaaa atacaaaaca     2400

cggcatttgg agggtactaa cgaagtggct cagccatctc gtgaatttgc ttctaaagca     2460

aaggacagtc attaccaaaa atcttcatca aaattggatg gaaactacaa aaatgagagt     2520

gatacctttt cagacagccg atcatcagac agagagacaa aacacaaaag gagaaaaagg     2580

aagacccgga gcctaagtgt agagatagtt tatgaaggaa aagctactga tacaactaaa     2640

caccataaaa agaaaaagaa gaaacataag aagaagcata agaaacacca tggagataat     2700

gcttcacgtt ccccagttgt aattaccatt gacagtgaca gtgataagga ttctgaagta     2760

aaggaggata cagaatgtga caatagtggt cctcaagacc ctctacaaaa tgagtttttg     2820

gctccttcct tggaaccatt tgaaactaaa gatgtagtta caatagaagc tgaatttggt     2880

gtgctggaca aggaatgtga tattgccaca cttagtaaca acttgaataa tgccaacaaa     2940

actgtagata atattccacc tctggcagct tcagttgaac aaactctcga tgtaagagaa     3000

gagagcacct ttgtttctga tttggagaac cagcccagta acattgtgtc tcttcaaact     3060

gagccatcaa ggcaattgcc atcgccacgg acatcattaa tgtcagtatg tcttggtaga     3120

gactgtgata tgtcttaa                                                   3138


<210>  556
<211>  2061
<212>  DNA
<213>  Homo sapiens;

<400>  556
atgtccctgc gagacaaggg cggggaagaa gaatgttttg aatacgactg ccaggatgaa       60

gagaggaagc caacccacag gcagcatgac acccaggacc tcttggaaga ggttttatgt      120

gctgaaagag ttggccagat gactaagaca tataatgaca tagatgctgt cactcggctt      180

cttgaggaga aagagcggga tttagaattg gccgctcgca tcggccagtc gttgttgaag      240

aagaacaaga ccctaaccga gaggaacgag ctgctggagg agcaggtgga acacatcagg      300

gaggaggtgt ctcagctccg gcatgagctg tccatgaagg atgagctgct tcagttctac      360

accagcgctg cggaggagag tgagcccgag tccgtttgct caaccccgtt gaagaggaat      420

gagtcgtcct cctcagtcca gaattacttt catttggatt ctcttcaaaa gaagctgaaa      480

gaccttgaag aggagaatgt tgtacttcga tccgaggcca gccagctgaa gacagagacc      540

atcacctatg aggagaagga gcagcagctg gtcaatgact gcgtgaagga gctgagggat      600

gccaatgtcc agattgctag tatctcagag gaactggcca agaagacgga agatgctgcc      660

cgccagcaag aggagatcac acacctgcta tcgcaaatag ttgatttgca gaaaaaggca      720

aaagcttgcg cagtggaaaa tgaagaactt gtccagcatc tgggggctgc taaggatgcc      780

cagcggcagc tcacagccga gctgcgtgag ctggaggaca agtacgcaga gtgcatggag      840

atgctgcatg aggcgcagga ggagctgaag aacctccgga acaaaaccat gcccaatacc      900

acgtctcggc gctaccactc actgggcctg tttcccatgg attccttggc agcagagatt      960

gagggaacga tgcgcaagga gctgcagttg gaagaggccg agtctccaga catcactcac     1020

cagaagcgtg tctttgagac agtaagaaac atcaaccagg ttgtcaagca gagatctctg     1080

accccttctc ccatgaacat ccccggctcc aaccagtcct cggccatgaa ctccctcctg     1140

tccagctgcg tcagcacccc ccggtccagc ttctacggca gcgacatagg caacgtcgtc     1200

ctcgacaaca agaccaacag catcattctg gaaacagagg cagccgacct gggaaacgat     1260

gagcggagta agaagccggg gacgccgggc accccaggct cccacgacct ggagacggcg     1320

ctgaggcggc tgtccctgcg ccgggagaac tacctctcgg agaggaggtt ctttgaggag     1380

gagcaagaga ggaagctcca ggagctggcg gagaagggcg agctgcgcag cggctccctc     1440

acacccactg agagcatcat gtccctgggc acgcactccc gcttctccga gttcaccggc     1500

ttctctggca tgtccttcag cagccgctcc tacctgcctg agaagctcca gatcgtgaag     1560

ccgctggaag gttccgccac acttcaccac tggcagcagt tggcccaacc tcaccttggg     1620

ggcatcctgg acccccggcc cggtgtggtc accaagggct tccggacgct ggatgttgac     1680

ctggacgaag tgtactgcct taacgacttt gaagaagatg acacaggtga ccacatttct     1740

ctcccacgcc tagctacctc cactccagtt cagcacccag agacctcagg tgagaggtcc     1800

caagcacgtg tgactgtctc aggcagcaga agttacccga gccggcctca ggcttcccca     1860

gaggagatgc aggagccgcc agcggccacg gaggaggagg aggaggagga ggaggaggag     1920

gggtctggtg agggcaccac gataagtcct gtaaacttgg cacctttccc ggaggcagag     1980

ttttgggcca ttctcacctc tgttccaggc accatccgta gtggttctct gtctgtagct     2040

tccgctcgtc tgtgtgggtg a                                               2061


<210>  557
<211>  705
<212>  DNA
<213>  Homo sapiens;

<400>  557
atgaggaaga ccaggctctg ggggctgctg tggatgctct ttgtctcaga actccgagct       60

gcaactaaat taactgagga aaagtatgaa ctgaaagagg ggcagaccct ggatgtgaaa      120

tgtgactaca cgctagagaa gtttgccagc agccagaaag cttggcagat aataagggac      180

ggagagatgc ccaagaccct ggcatgcaca gagaggcctt caaagaattc ccatccagtc      240

caagtgggga ggatcatact agaagactac catgatcatg gtttactgcg cgtccgaatg      300

gtcaaccttc aagtggaaga ttctggactg tatcagtgtg tgatctacca gcctcccaag      360

gagcctcaca tgctgttcga tcgcatccgc ttggtggtga ccaagggttt ttcagggacc      420

cctggctcca atgagaattc tacccagaat gtgtataaga ttcctcctac caccactaag      480

gccttgtgcc cactctatac cagccccaga actgtgaccc aagctccacc caagtcaact      540

gccgatgtct ccactcctga ctctgaaatc aaccttacaa atgtgacaga tatcatcagg      600

gttccggtgt tcaacattgt cattctcctg gctggtggat tcctgagtaa gagcctggtc      660

ttctctgtcc tgtttgctgt cacgctgagg tcatttgtac cctag                      705


<210>  558
<211>  1032
<212>  DNA
<213>  Homo sapiens;

<400>  558
atgaacatac acaggtctac ccccatcaca atagcgagat atgggagatc gcggaacaaa       60

acccaggatt tcgaagagtt gtcgtctata aggtccgcgg agcccagcca gagtttcagc      120

ccgaacctcg gctccccgag cccgcccgag actccgaact tgtcgcattg cgtttcttgt      180

atcgggaaat acttattgtt ggaacctctg gagggagacc acgtttttcg tgccgtgcat      240

ctgcacagcg gagaggagct ggtgtgcaag gtgtttgata tcagctgcta ccaggaatcc      300

ctggcaccgt gcttttgcct gtctgctcat agtaacatca accaaatcac tgaaattatc      360

ctgggtgaga ccaaagccta tgtgttcttt gagcgaagct atggggacat gcattccttc      420

gtccgcacct gcaagaagct gagagaggag gaggcagcca gactgttcta ccagattgcc      480

tcggcagtgg cccactgcca tgacgggggg ctggtgctgc gggacctcaa gctgcggaaa      540

ttcatcttta aggacgaaga gaggactcgg gtcaagctgg aaagcctgga agacgcctac      600

attctgcggg gagatgatga ttccctctcc gacaagcatg gctgcccggc ttacgtaagc      660

ccagagatct tgaacaccag tggcagctac tcgggcaaag cagccgacgt gtggagcctg      720

ggggtgatgc tgtacaccat gttggtgggg cggtaccctt tccatgacat tgaacccagc      780

tccctcttca gcaagatccg gcgtggccag ttcaacattc cagagactct gtcgcccaag      840

gccaagtgcc tcatccgaag cattctgcgt cgggagccct cagagcggct gacctcgcag      900

gaaattctgg accatccttg gttttctaca gattttagcg tctcgaattc agcatatggt      960

gctaaggaag tgtctgacca gctggtgccg gacgtcaaca tggaagagaa cttggaccct     1020

ttctttaact ga                                                         1032


<210>  559
<211>  1656
<212>  DNA
<213>  Homo sapiens;

<400>  559
atggcggaga attggaagaa ctgcttcgag gaggagctca tctgccctat ctgcctgcac       60

gttttcgtgg agccagtgca gctgccgtgc aaacacaact tctgccgggg ctgcatcggc      120

gaggcgtggg ccaaggacag cggcctcgta cgctgcccag agtgcaacca ggcctacaac      180

cagaagccgg gcctggagaa gaacctgaag ctcaccaaca tcgtggagaa gttcaatgcc      240

ctgcacgtgg agaagccgcc ggcggcgctg cactgcgtgt tctgccgccg cggccccccg      300

ctgcccgcgc agaaggtctg cctgcgctgc gaggcgccct gctgccagtc ccacgtgcag      360

acgcacctgc agcagccctc caccgcccgc gggcacctcc tggtggaggc ggacgacgtg      420

cgggcctgga gctgcccgca gcacaacgcc taccgcctct accactgcga ggccgagcag      480

gtggccgtgt gccagtactg ctgctactac agcggcgcgc atcagggaca ctcggtgtgc      540

gacgtggaga tccgaaggaa tgaaatccgg aagatgctca tgaagcagca ggaccggctg      600

gaggagcgag agcaggacat tgaggaccag ctgtacaaac tcgagtcaga caagcgcctg      660

gtggaggaga aagtgaacca actgaaggag gaagttcggc tgcagtacga gaagctgcac      720

cagctgctgg acgaggacct gcggcagaca gtggaggtcc tagacaaggc ccaggccaag      780

ttctgcagcg agaacgcagc gcaggcgctg cacctcgggg agcgcatgca ggaggccaag      840

aagctgctgg gctccctgca gctgctcttt gataagacgg aggatgtcag cttcatgaag      900

aacaccaagt ctgtgaaaat cctgatggac aggacccaga cctgcacgag cagcagcctt      960

tcccccacta agatcggcca cctgaactcc aagctcttcc tgaacgaagt ggccaagaag     1020

gagaagcagc tgcggaaaat gctagaaggc cccttcagca cgccggtgcc cttcctgcag     1080

agtgtccccc tgtacccttg cggcgtgagc agctctgggg cggaaaagcg caagcactca     1140

acggccttcc cagaggccag tttcctagag acgtcgtcgg gccctgtggg cggccagtac     1200

ggggcggcgg gcacagccag cggtgagggc cagtctgggc agcccctggg gccctgcagc     1260

tccacgcagc acttggtggc cctgccgggc ggcgcccaac cagtgcactc aagccccgtg     1320

ttccccccat cgcagtatcc caatggctcc gccgcccagc agcccatgct cccccagtat     1380

ggcggccgca agattctcgt ctgttctgtg gacaactgtt actgttcttc cgtggccaac     1440

catggcggcc accagcccta cccccgctcc ggccactttc cctggacagt gccctcgcag     1500

gagtactcac acccgctccc gcccacaccc tccgtccccc agtcccttcc cagcctggcg     1560

gtcagagact ggcttgacgc ctcccagcag cccggccacc aggatttcta cagggtgtat     1620

gggcagccgt ccaccaaaca ctacgtgacg agctaa                               1656


<210>  560
<211>  1959
<212>  DNA
<213>  Homo sapiens;

<400>  560
atgggcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga ggcgcggcgg       60

cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc gcggagcccg      120

gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg cgccgccatg      180

acgcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga gcctggagag      240

cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca ttggtttgtg      300

ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc agatgagctg      360

gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt gcagcgcaac      420

tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat gacctcaggc      480

atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc agccccagat      540

gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag cacccagaag      600

ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg gggtggccct      660

cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc gctgacccag      720

gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc caagcaggag      780

gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt tgaggccaca      840

gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct gggtgccccc      900

ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg gcaggagctg      960

gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct caaccaaagc     1020

cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa ggaggttcag     1080

gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca gagtgcactg     1140

agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc atgtgagcgc     1200

agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca gcggcaccac     1260

gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga ggagacggca     1320

gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct gagccgagag     1380

ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca gcaccagtca     1440

gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc gcagaagtgc     1500

ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct gcgccgctgc     1560

cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg cctgtcagag     1620

gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg ctgcgggcgc     1680

agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga aaacgaactc     1740

cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat gcagaaggac     1800

aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca catcaagaca     1860

cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat ggccgccctc     1920

caggagaagg agtcgatgcg caacagcctg gctgagtag                            1959


<210>  561
<211>  405
<212>  DNA
<213>  Homo sapiens;

<400>  561
atgaacaccg aaatgtatca gacccccatg gaggtggcgg tctaccagct gcacaatttc       60

tccatctcct tcttctcttc tctgcttgga ggggatgtgg tttccgttaa gctggacaac      120

agtgcctccg gagccagcgt ggtggccata gacaacaaga tcgaacaggc catggatctg      180

gtgaagaatc atctgatgta tgctgtgaga gaggaggtgg agatcctgaa ggagcagatc      240

cgagagctgg tggagaagaa ctcccagcta gagcgtgaga acaccctgtt gaagaccctg      300

gcaagcccag agcagctgga gaagttccag tcctgtctga gccctgaaga gccagctccc      360

gaatccccac aagtgcccga ggcccctggt ggttctgcgg tgtaa                      405


<210>  562
<211>  3564
<212>  DNA
<213>  Homo sapiens;

<400>  562
atgcctctgc gccactgggg gatggccagg ggcagtaagc ccgttgggga tggagcccag       60

cccatggctg ccatgggagg cctgaaggtg cttctgcact gggctggtcc aggcggcggg      120

gagccctggg tcactttcag tgagtcatcg ctgacagctg aggaagtctg catccacatt      180

gcacataaag ttggtatcac tcctccttgc ttcaatctct ttgccctctt cgatgctcag      240

gcccaagtct ggttgccccc aaaccacatc ctagagatcc ccagagatgc aagcctgatg      300

ctatatttcc gcataaggtt ttatttccgg aactggcatg gcatgaatcc tcgggaaccg      360

gctgtgtacc gttgtgggcc cccaggaacc gaggcatcct cagatcagac agcacagggg      420

atgcaactcc tggacccagc ctcatttgag tacctctttg agcagggcaa gcatgagttt      480

gtgaatgacg tggcatcact gtgggagctg tcgaccgagg aggagatcca ccactttaag      540

aatgagagcc tgggcatggc ctttctgcac ctctgtcacc tcgctctccg ccatggcatc      600

cccctggagg aggtggccaa gaagaccagc ttcaaggact gcatcccgcg ctccttccgc      660

cggcatatcc ggcagcacag cgccctgacc cggctgcgcc ttcggaacgt cttccgcagg      720

ttcctgcggg acttccagcc gggccgactc tcccagcaga tggtcatggt caaataccta      780

gccacactcg agcggctggc accccgcttc ggcacagagc gtgtgcccgt gtgccacctg      840

aggctgctgg cccaggccga gggggagccc tgctacatcc gggacagtgg ggtggcccct      900

acagaccctg gccctgagtc tgctgctggg cccccaaccc acgaggtgct ggtgacaggc      960

actggtggca tccagtggtg gccagtagag gaggaggtga acaaggagga gggttctagt     1020

ggcagcagtg gcaggaaccc ccaagccagc ctgtttggga agaaggccaa ggctcacaag     1080

gcagtcggcc agccggcaga caggccgcgg gagccactgt gggcctactt ctgtgacttc     1140

cgggacatca cccacgtggt gctgaaagag cactgtgtca gcatccaccg gcaggacaac     1200

aagtgcctgg agctgagctt gccttcccgg gctgcggcgc tgtccttcgt gtcgctggtg     1260

gacggctatt tccgcctgac ggccgactcc agccactacc tgtgccacga ggtggctccc     1320

ccacggctgg tgatgagcat ccgggatggg atccacggac ccctgctgga gccatttgtg     1380

caggccaagc tgcggcccga ggacggcctg tacctcattc actggagcac cagccacccc     1440

taccgcctga tcctcacagt ggcccagcgt agccaggcac cagacggcat gcagagcttg     1500

cggctccgaa agttccccat tgagcagcag gacggggcct tcgtgctgga gggctggggc     1560

cggtccttcc ccagcgttcg ggaacttggg gctgccttgc agggctgctt gctgagggcc     1620

ggggatgact gcttctctct gcgtcgctgt tgcctgcccc aaccaggaga aacctccaat     1680

ctcatcatca tgcggggggc tcgggccagc cccaggacac tcaacctcag ccagctcagc     1740

ttccaccggg ttgaccagaa ggagatcacc cagctgtccc acttgggcca gggcacaagg     1800

accaacgtgt atgagggccg cctgcgagtg gagggcagcg gggaccctga ggagggcaag     1860

atggatgacg aggaccccct cgtgcctggc agggaccgtg ggcaggagct acgagtggtg     1920

ctcaaagtgc tggaccctag tcaccatgac atcgccctgg ccttctacga gacagccagc     1980

ctcatgagcc aggtctccca cacgcacctg gccttcgtgc atggcgtctg tgtgcgcggc     2040

cctgaaaata tcatggtgac agagtacgtg gagcacggac ccctggatgt gtggctgcgg     2100

agggagcggg gccatgtgcc catggcttgg aagatggtgg tggcccagca gctggccagc     2160

gccctcagct acctggagaa caagaacctg gttcatggta atgtgtgtgg ccggaacatc     2220

ctgctggccc ggctggggtt ggcagagggc accagcccct tcatcaagct gagtgatcct     2280

ggcgtgggcc tgggcgccct ctccagggag gagcgggtgg agaggatccc ctggctggcc     2340

cccgaatgcc taccaggtgg ggccaacagc ctaagcaccg ccatggacaa gtgggggttt     2400

ggcgccaccc tcctggagat ctgctttgac ggagaggccc ctctgcagag ccgcagtccc     2460

tccgagaagg agcatttcta ccagaggcag caccggctgc ccgagccctc ctgcccacag     2520

ctggccacac tcaccagcca gtgtctgacc tatgagccaa cccagaggcc atcattccgc     2580

accatcctgc gtgacctcac ccggctgcag ccccacaatc ttgctgacgt cttgactgtg     2640

aacccggact caccggcgtc ggaccctacg gttttccaca agcgctattt gaaaaagatc     2700

cgagatctgg gcgagggtca cttcggcaag gtcagcttgt actgctacga tccgaccaac     2760

gacggcactg gcgagatggt ggcggtgaaa gccctcaagg cagactgcgg cccccagcac     2820

cgctcgggct ggaagcagga gattgacatt ctgcgcacgc tctaccacga gcacatcatc     2880

aagtacaagg gctgctgcga ggaccaaggc gagaagtcgc tgcagctggt catggagtac     2940

gtgcccctgg gcagcctccg agactacctg ccccggcaca gcatcgggct ggcccagctg     3000

ctgctcttcg cccagcagat ctgcgagggc atggcctatc tgcacgcgca gcactacatc     3060

caccgagacc tagccgcgcg caacgtgctg ctggacaacg acaggctggt caagatcggg     3120

gactttggcc tagccaaggc cgtgcccgaa ggccacgagt actaccgcgt gcgcgaggat     3180

ggggacagcc ccgtgttctg gtatgcccca gagtgcctga aggagtataa gttctactat     3240

gcgtcagatg tctggtcctt cggggtgacc ctgtatgagc tgctgacgca ctgtgactcc     3300

agccagagcc cccccacgaa attccttgag ctcataggca ttgctcaggg tcagatgaca     3360

gttctgagac tcactgagtt gctggaacga ggggagaggc tgccacggcc cgacaaatgt     3420

ccctgtgagg tctatcatct catgaagaac tgctgggaga cagaggcgtc ctttcgccca     3480

accttcgaga acctcatacc cattctgaag acagtccatg agaagtacca aggccaggcc     3540

ccttcagtgt tcagcgtgtg ctga                                            3564


<210>  563
<211>  342
<212>  DNA
<213>  Homo sapiens;

<400>  563
atggggggac ttgaaccctg cagcaggctc ctgctcctgc ctctcctgct ggctgtaagt       60

ggtctccgtc ctgtccaggc ccaggcccag agcgattgca gttgctctac ggtgagcccg      120

ggcgtgctgg cagggatcgt gatgggagac ctggtgctga cagtgctcat tgccctggcc      180

gtgtacttcc tgggccggct ggtccctcgg gggcgagggg ctgcggaggc agcgacccgg      240

aaacagcgta tcactgagac cgagtcgcct tatcaggagc tccagggtca gaggtcggat      300

gtctacagcg acctcaacac acagaggccg tattacaaat ga                         342


<210>  564
<211>  444
<212>  DNA
<213>  Homo sapiens;

<400>  564
atggctctga agagaatcca caaggaattg aatgatctgg cacgggaccc tccagcacag       60

tgttcagcag gtcctgttgg agatgatatg ttccattggc aagctacaat aatggggcca      120

aatgacagtc cctatcaggg tggagtattt ttcttgacaa ttcatttccc aacagattac      180

cccttcaaac cacctaaggt tgcatttaca acaagaattt atcatccaaa tattaacagt      240

aatggcagca tttgtcttga tattctacga tcacagtggt ctccagcact aactatttca      300

aaagtactct tgtccatctg ttctctgttg tgtgatccca atccagatga tcctttagtg      360

cctgagattg ctcggatcta caaaacagat agagaaaagt acaacagaat agctcgggaa      420

tggactcaga agtatgcgat gtaa                                             444


<210>  565
<211>  462
<212>  DNA
<213>  Homo sapiens;

<400>  565
atgatggcga gcatgcgagt ggtgaaggag ctggaggatc ttcagaagaa gcctccccca       60

tacctgcgga acctgtccag cgatgatgcc aatgtcctgg tgtggcacgc tctcctccta      120

cccgaccaac ctccctacca cctgaaagcc ttcaacctgc gcatcagctt cccgccggag      180

tatccgttca agcctcccat gatcaaattc acaaccaaga tctaccaccc caacgtggac      240

gagaacggac agatttgcct gcccatcatc agcagtgaga actggaagcc ttgcaccaag      300

acttgccaag tcctggaggc cctcaatgtg ctggtgaata gaccgaatat cagggagccc      360

ctgcggatgg acctcgctga cctgctgaca cagaatccgg agctgttcag aaagaatgcc      420

gaagagttca ccctccgatt cggagtggac cggccctcct aa                         462


<210>  566
<211>  3405
<212>  DNA
<213>  Homo sapiens;

<400>  566
atgtcggagc cccacagggt ccagttcacc tctctcccag gttccctgaa tcctgcgttt       60

ttgaagaagt cccggaagga ggaggctggg gcaggagaac agcatcagga ctgtgagccg      120

gctgcagcag ctgttcggat tacactcacc ctctttgaac cagatcacaa acgctgccca      180

gagttcttct acccagagct ggtgaagaat atccgaggga aggtaaaagg ccttcagcct      240

ggagataaga agaaagatct gtcagatcct ttcaatgacg aagaaaagga aaggcataaa      300

gtagaggccc ttgcccgaaa atttgaagaa aaatacggtg gaaagaaacg tagaaaagac      360

cgaatacagg acttgatcga tatggggtat ggttatgatg aatccgactc cttcatcgat      420

aactctgagg cgtatgatga gcttgttcct gcttctttga ctacgaagta tggaggattt      480

tacattaact cgggaaccct gcagtttaga caagcatcag agtctgaaga tgacttcatt      540

aaagaaaaga agaaaaaatc tccaaagaag cggaagttga aggaaggtgg tgagaagata      600

aagaagaaga aaaaagatga cacttatgac aaggagaaga aatcgaaaaa gtccaagttt      660

tccaaagccg gcttcacagc cctcaatgcc agtaaggaga agaagaagaa gaaatattct      720

ggggctttaa gcgttaaaga gatgctaaag aaatttcaga aagagaaaga ggctcagaaa      780

aaaagggagg aggagcataa gcctgttgcg gtcccatcag cggaagctca gggcctgcgg      840

gaactggagg gtgcctctga ccccttgctc tcactctttg gctctacttc tgacaacgac      900

ttgctccagg cggccactgc catggactcg ctgacggatt tggacttgga gcatctgctc      960

agtgagtctc cagaaggaag tcccttccga gatatggatg atggaagtga ttcccttggg     1020

gtgggattgg accaggaatt caggcagccc tcttctctcc ccgaaggcct gccagcaccc     1080

ctggagaagc gcgttaagga gctggctcag gctgccagag ctgctgaggg ggagagcaga     1140

cagaagttct tcacccagga tattaatgga atcctattag acatagaggc gcagactcgg     1200

gagctgagca gtcaggtccg ctctggggtg tatgcctatc ttgcgtcatt cctgccctgc     1260

agcaaggatg ccctgctcaa gcgtgctcgg aaacttcacc tctatgaaca ggggggccgt     1320

ctgaaggagc ctctccagaa gctcaaggaa gccattggca gggcgatgcc agagcagatg     1380

gccaagtacc aggacgaatg ccaggcacac acgcaggcaa aggttgccaa gatgctggaa     1440

gaggagaaag acaaggagca gagggaccgg atttgttcgg atgaggaaga agatgaagaa     1500

aaagggggca ggaggataat gggacctcgg aagaagttcc aatggaatga tgagatcagg     1560

gagctactgt gccaggtggt gaagatcaaa ctggagagcc aggacctgga gaggaacaac     1620

aaagcccagg cttgggagga ctgtgtgaag ggctttctgg atgcggaagt caagcccctc     1680

tggcccaaag gctggatgca ggccagaact ctgtttaagg agagcagacg aggccatggg     1740

cacctgactt caatcctggc caagaagaaa gttatggccc cttctaaaat caaggtgaag     1800

gaatcgtcta cgaagcctga taaaaaggtt tctgtcccat caggacagat tggtggcccc     1860

attgctttgc cctcagatca ccaaacagga ggcctgagta ttggggcctc gagcagggag     1920

ctcccatccc aggcatcggg cggccttgct aaccctcctc ctgtcaacct ggaggactca     1980

ttggatgaag acttgatccg caatccagcc tcctcggtgg aagccgtgtc caaggaattg     2040

gctgcattga atagcagagc agctgggaac tctgaattca cactgcctgc accctcaaaa     2100

gcacctgcag aaaaagttgg aggcgtttta tgtacagaag aaaaaaggaa ctttgcgaag     2160

cctagtcctt ctgctccacc accagctagc tctctgcagt cacccctcaa ttttctggca     2220

gaacaggctc tggcactggg gcagtcctct caggagaaaa aaccagagag ttctggctac     2280

aaagagctgt cctgccaggc tcccctcaat aagggcctgc cagaagtaca tcagtccaaa     2340

gctaagcacc acagcttgcc acggacgtct cacgggcccc aagtggcagt tcctgtgcct     2400

ggcccccagg tcaaagtctt tcatgccggc actcagcagc agaaaaactt cacgccccca     2460

tctccatttg ccaataagct ccaaggccca aaggcttctc ccacacagtg tcatcgttcc     2520

ctcctgcagt tagtgaagac agcggccaaa ggccagggct tccatccctc tgcaccagcc     2580

acctcaggag gcctgtcagc ctccagcagc agctctcaca agaccccagc ctcgtcctct     2640

tctgccctga gccatccagc aaagccacat tcagtcagct ctgcaggctc atcttacaag     2700

aataatccct ttgccagctc aatctccaaa catggggttt cttctggcag ctcttcctcg     2760

ggaggaacac cagtccagag ttctgtttct gggagcctgg tccctggcat acagcctccc     2820

tccgtgggac aggccaccag ccgacccgtc ccaagttcag cagggaaaaa aatgcctgtt     2880

tcccagaagt tgactctggt agcccctcca ggcggtccaa acggagattc cagtggtggg     2940

acccagggag tggcaaagtt gctgacctcg ccgtccctaa agccctctgc agttagtagt     3000

gtgacatcgt ctacctcctt gtcaaaagga gcgagtggga ctgtgctgct ggccggctcc     3060

tctttgatgg cttcacccta caaatccagc agcccaaagc tgtctggggc catgagctcg     3120

aactccttgg gaattataac ccctgtccct attcctgtcc atgtgctctc cttcagcgct     3180

gactcctctg ccaaagcagg ggtctccaag gatgccatcg tcacaggccc tgcccccggg     3240

tccttccacc atggccttgg ccacagtctt ctggctggct tgcactccag cccgccccat     3300

gcagcgcctc tcccacacgc tgcggtgccc acccatatcc cgcagagtct gccaggtgct     3360

tctcagcttc acgggaaagg gcctgctgta ccacggaaat tgtga                     3405


<210>  567
<211>  1875
<212>  DNA
<213>  Homo sapiens;

<400>  567
atggctgaga atggcgagag cagcggcccc ccgcgcccct cccgcggccc tgctgcggcc       60

caaggctcgg ctgctgcccc ggctgagcct aaaatcatca aagtcacggt gaagactccc      120

aaagagaaag aggagttcgc ggtgcccgag aacagctcgg ttcagcagtt taaggaagcg      180

atttcgaaac gcttcaaatc ccaaaccgat cagctagtgc tgatttttgc cggaaaaatc      240

ttaaaagatc aagatacctt gatccagcat ggcatccatg atgggctgac tgttcacctt      300

gtcatcaaaa gccagaaccg acctcagggc cagtccacgc agcctagcaa tgccgcggga      360

actaacacta cctcggcgtc gactcccagg agtaactcca cacctatttc cacaaatagc      420

aacccgtttg ggttggggag cctgggagga cttgcaggcc ttagcagcct gggcttgagc      480

tcgaccaact tctctgagct ccagagccag atgcagcagc agcttatggc cagccctgag      540

atgatgatcc aaataatgga aaatcccttt gttcagagca tgctttcgaa tcccgatctg      600

atgaggcagc tcattatggc taatccacag atgcagcaat tgattcagag aaacccagaa      660

atcagtcacc tgctcaacaa cccagacata atgaggcaga cactcgaaat tgccaggaat      720

ccagccatga tgcaagagat gatgagaaat caagacctgg ctcttagcaa tctagaaagc      780

atcccaggtg gctataatgc tttacggcgc atgtacactg acattcaaga gccgatgctg      840

aatgccgcac aagagcagtt tgggggtaat ccatttgcct ccgtggggag tagttcctcc      900

tctggggaag gtacgcagcc ttcccgcaca gaaaatcgcg atccactacc caatccatgg      960

gcaccaccgc cagctaccca gagttctgca actaccagca cgaccacaag cactggtagt     1020

gggtctggca atagttccag caatgctact gggaacaccg ttgctgccgc taattatgtc     1080

gccagcatct ttagtacccc aggcatgcag agcctgctgc aacagataac tgaaaacccc     1140

cagctgattc agaatatgct gtcggcgccc tacatgagaa gcatgatgca gtcgctgagc     1200

cagaatccag atttggctgc acagatgatg ctgaatagcc cgctgtttac tgcaaatcct     1260

cagctgcagg agcagatgcg gccacagctc ccagccttcc tgcagcagat gcagaatcca     1320

gacacactat cagccatgtc aaacccaaga gcaatgcagg ctttaatgca gatccagcag     1380

gggctacaga cattagccac tgaagcacct ggcctgattc cgagcttcac tccaggtgtg     1440

ggggtggggg tgctgggaac cgctataggc cctgtaggcc cagtcacccc cataggcccc     1500

ataggcccta tagtcccttt tacccccata ggccccattg ggcccatagg acccactggc     1560

cctgcagccc cccctggctc caccggctct ggtggcccca cggggcctac tgtgtccagc     1620

gctgcaccta gtgaaaccac gagtcctaca tcagaatctg gacccaacca gcagttcatt     1680

cagcaaatgg tgcaggccct ggctggagca aatgctccac agctgccgaa tccagaagtc     1740

agatttcagc aacaactgga acagctcaac gcaatggggt tcttaaaccg tgaagcaaac     1800

ttgcaggccc taatagcaac aggaggcgac atcaatgcag ccattgaaag gctgctgggc     1860

tcccagccat cgtaa                                                      1875


<210>  568
<211>  996
<212>  DNA
<213>  Homo sapiens;

<400>  568
atggcggagg gcggaggccc tgagcccggc gagcaggaga ggaggtcttc cgggccgcgg       60

cctccgagcg cgcgggattt gcagttggcc ttggcagaat tgtatgaaga tgaagtgaag      120

tgcaaatctt ccaagtctaa tagacctaaa gccacagtct tcaagagccc acggacacca      180

cctcaacggt tttactcaag tgaacatgaa tacagtggat taaatatagt tcgaccttca      240

actgggaaaa ttgtgaatga acttttcaaa gaggcaaggg aacatggggc tgtccctctg      300

aatgaagcca caagagcttc aggtgatgat aaatctaagt catttacagg tggaggatac      360

agattgggta gttctttttg taagcggtct gaatatatct atggagaaaa tcagctgcaa      420

gatgttcaga ttttgcttaa actgtggagc aatggtttca gtttagatga tggagaattg      480

agaccttaca atgaaccaac aaatgctcaa tttctggagt ctgttaagag aggagagatt      540

cccctggagc ttcagcgcct tgttcatggt ggccaagtga atttggatat ggaggatcat      600

caggatcaag aatacataaa acctagattg aggttcaagg cttttagtgg agaagggcaa      660

aaacttggaa gccttacacc tgaaatagtc agtacacctt cctctccaga agaggaggat      720

aaatcaatac ttaatgcagt tgttcttatt gatgattcag tgccaacaac aaaaattcaa      780

atcaggttag cagatgggag tcgtttgata caaagattca atagtacaca caggatcctg      840

gatgtccgga actttattgt acagtctcgt cctgaatttg cggctcttga ctttattctt      900

gtgacttcat ttccgaataa agagctaaca gatgaaagcc tgacactgct agaagcagat      960

attcttaaca ctgtgttact ccagcaacta aaataa                                996


<210>  569
<211>  2397
<212>  DNA
<213>  Homo sapiens;

<400>  569
atggccctcc acagcccgca gtatattttt ggagatttta gccctgatga attcaatcaa       60

ttctttgtga ctcctcgatc ttcagttgag cttcctccat acagtggaac agttctgtgt      120

ggcacacagg ctgtggataa actacctgat ggacaagaat atcagagaat tgagtttggt      180

gtcgatgaag tcattgaacc cagtgacact ttgccgagaa cccccagcta cagtatttca      240

agcacactga accctcaggc ccctgaattt attctcggtt gtacagcttc caaaataacc      300

cctgatggta tcactaaaga agcaagctat ggctccatcg actgccagta cccaggctct      360

gccctcgctt tggatggaag ttctaatgtg gaggcggaag ttttggaaaa tgatggtgtc      420

tcaggtggtc ttggacaaag ggagcgtaaa aagaagaaaa agcggccacc tggatattac      480

agctatttga aagatggtgg cgatgatagt atctccacag aagccctggt caatggccat      540

gccaattcag cagtcccgaa cagtgtcagt gcagaggatg cagaatttat gggtgacatg      600

cccccgtcag ttacgcccag gacttgtaac agcccccaga actccacaga ctctgtcagt      660

gacattgtgc ctgacagtcc tttccccgga gcactcggca gtgacaccag gactgcaggg      720

cagccagagg ggggccccgg ggctgatttt ggtcagtcct gcttccctgc agaggctggc      780

agagacaccc tgtcaaggac agctggggct cagccctgcg ttggtaccga tactactgaa      840

aaccttggag ttgctaatgg acaaatactt gaatcctcgg gtgagggcac agctaccaac      900

ggggtggagt tgcacaccac ggaaagcata gacttggacc caaccaaacc cgagagtgca      960

tcacctcctg ctgacggcac gggctctgca tcaggcaccc ttcctgtcag ccagcccaag     1020

tcctgggcca gcctctttca tgattctaag ccctcttcct cctcgccggt ggcctatgtg     1080

gaaactaagt attcccctcc cgccatatct cccctggttt ctgaaaagca ggttgaagtc     1140

aaagaagggc ttgttccggt ttcagaggat cctgtagcca taaagattgc agagttgctg     1200

gagaatgtaa ccctaatcca taaaccagtg tcgttgcaac cccgtgggct gatcaataaa     1260

gggaactggt gctacattaa tgctacactg caggcattgg ttgcttgccc gccgatgtac     1320

cacctgatga agttcattcc tctgtattcc aaagtgcaaa ggccttgtac gtcaacaccc     1380

atgatagaca gctttgttcg gctaatgaat gagttcacta atatgccagt acctccaaaa     1440

ccccgacaag ctcttggaga taaaatcgtg agggatattc gccctggagc tgcctttgag     1500

cccacatata tttacagact cctgacagtt aacaagtcaa gcctgtctga aaagggtcga     1560

caagaagatg ctgaggaata cttaggcttc attctaaatg gacttcatga ggaaatgttg     1620

aacctaaaga agcttctctc accaagtaat gaaaaactta cgatttccaa cggccccaaa     1680

aaccactcgg tcaatgaaga agagcaggaa gaacaaggtg aaggaagcga ggatgaatgg     1740

gaacaagtgg gcccccggaa caagacttcc gtcacccgcc aggcggattt tgttcagact     1800

ccaatcaccg gcatttttgg tggacacatc aggtctgtgg tttaccagca gagttcaaaa     1860

gaatctgcca ctttgcagcc atttttcacg ttgcagttgg atatccagtc agacaagata     1920

cgcacagtcc aggatgcact ggagagcttg gtggcaagag aatctgtcca aggttatacc     1980

acaaaaacca aacaagaggt tgagataagt cgaagagtga ctctggaaaa actccctcct     2040

gtcctcgtgc tgcacctgaa acgattcgtt tatgagaaga ctggtgggtg ccagaagctt     2100

atcaaaaata ttgaatatcc tgtggacttg gaaattagta aagaactgct ttctccaggg     2160

gttaaaaata agaattttaa atgccaccga acctatcggc tctttgcagt ggtctaccat     2220

cacggcaaca gtgcgacggg cggccattac actacagacg tcttccagat cggtctgaat     2280

ggctggctgc gcatcgatga ccagacagtc aaggtgatca accagtacca ggtggtgaaa     2340

ccaactgctg aacgcacagc ctacctcctg tattaccgcc gagtggacct gctgtaa        2397


<210>  570
<211>  2859
<212>  DNA
<213>  Homo sapiens;

<400>  570
atggcggaag gcggagcggc ggatctggac acccagcggt ctgacatcgc gacgctgctc       60

aaaacctcgc tccggaaagg ggacacctgg tacctagtcg atagtcgctg gttcaaacag      120

tggaaaaaat atgttggctt tgacagttgg gacaaatacc agatgggaga tcaaaatgtg      180

tatcctggac ccattgataa ctctggactt ctcaaagatg gtgatgccca gtcacttaag      240

gaacacctta ttgatgaatt ggattacata ctgttgccaa ctgaaggttg gaataaactt      300

gtcagctggt acacattgat ggaaggtcaa gagccaatag cacgaaaggt ggttgaacag      360

ggtatgtttg taaagcactg caaagtagaa gtatatctca cagaattgaa gctatgtgaa      420

aatggaaaca tgaataatgt tgtaactcga agatttagca aagctgacac aatagataca      480

attgaaaagg aaataagaaa aatcttcagt attccagatg aaaaggagac cagattgtgg      540

aacaaataca tgagtaacac atttgaacca ctgaataaac cagacagcac cattcaggat      600

gctggtttat accaaggaca ggtattagtg atagaacaga aaaatgaaga tggaacatgg      660

ccaaggggtc cttctactcc taatgtgaaa aactcaaatt actgtcttcc atcatatacc      720

gcttataaga actatgatta ttcggaacct ggaagaaaca atgaacagcc aggcctctgt      780

ggcctaagta acttgggaaa tacgtgtttc atgaactcag ctattcagtg tttgagcaac      840

acacctccac ttactgagta tttcctcaat gataagtatc aagaagaact gaattttgac      900

aatcccttag gaatgagagg tgaaatagct aaatcttatg ccgaactgat caagcaaatg      960

tggtctggaa agtttagcta cgtcacccca agagccttta agacacaggt aggacgtttt     1020

gcacctcagt tctctggata tcagcagcaa gactgtcaag aactgttagc tttcctatta     1080

gatggattac atgaggattt gaatagaatt aggaaaaaac catatataca attaaaagat     1140

gcagatggaa ggccagataa ggtggttgcc gaagaagcct gggaaaacca tttaaaacga     1200

aatgattcta tcatagtaga tatatttcat ggccttttca aatcaacttt agtttgtcct     1260

gagtgtgcta agatttcagt aacatttgat cctttttgtt acttgacact tccattgccc     1320

atgaaaaaag aacgcacctt ggaagtttac ttagttagaa tggatccact taccaaacct     1380

atgcagtaca aagtggttgt ccccaaaatt ggaaacatat tagatctttg tacagcattg     1440

tctgctttgt caggaatacc tgcagataag atgatagtta ctgatatata caatcataga     1500

tttcacagaa tattcgctat ggatgaaaac cttagtagta ttatggaacg ggatgatatt     1560

tatgtgtttg aaattaacat caataggaca gaagatacag agcacgtgat tattcctgtt     1620

tgcctaagag aaaaattcag acactcgagt tatacccacc atactggttc ttcacttttt     1680

ggtcagccct ttcttatggc tgtaccacga aacaatactg aagacaaact ttataatctc     1740

ctgctcttga gaatgtgccg atatgtcaaa atatctactg aaactgaaga aactgaagga     1800

tccctacact gctgtaagga ccaaaatatt aatgggaatg gcccaaatgg catacatgaa     1860

gaaggctcac caagtgaaat ggaaacagat gagccagatg atgaatccag ccaggatcaa     1920

gaacttccct cagagaatga aaacagtcag tctgaagatt cagttggagg agataatgat     1980

tctgaaaatg gattatgtac tgaggatact tgcaaaggtc aactcacggg acacaaaaaa     2040

cgattgttta cattccagtt caacaactta ggcaatactg atatcaacta catcaaagat     2100

gataccaggc atataagatt tgatgatagg cagcttaggc tagatgaaag atcttttctt     2160

gctttggatt gggatcctga tttgaaaaaa agatattttg atgaaaatgc tgctgaggac     2220

tttgaaaaac atgaaagtgt ggagtataaa cctcctaaaa aaccctttgt gaaattaaaa     2280

gattgcattg aactttttac aacaaaagaa aagctaggtg ctgaagatcc ctggtattgt     2340

ccgaattgta aagaacatca gcaagccaca aagaaattgg atttatggtc cctgcctcca     2400

gtacttgtag tacatctcaa gcgattttct tacagtcgat acatgagaga caagttggat     2460

accttagttg attttcctat caatgacttg gatatgtcgg aattcttaat taatccaaat     2520

gcaggtcctt gccgctataa tctgattgct gtttccaacc actatggagg gatgggagga     2580

ggacactata ctgcttttgc aaaaaataaa gatgatggaa aatggtacta ttttgatgac     2640

agtagtgtct ccactgcatc tgaagaccaa attgtgtcca aagcagcata tgtactcttc     2700

taccagagac aagacacttt cagtggaact ggcttttttc ctcttgaccg agaaactaaa     2760

ggtgcttcag ctgccactgg catcccatta gaaagtgatg aagatagcaa tgataatgac     2820

aatgatatag aaaatgaaaa ctgtatgcac actaactaa                            2859


<210>  571
<211>  1119
<212>  DNA
<213>  Homo sapiens;

<400>  571
atgagcaagg cgtttgggct cctgaggcaa atctgtcagt ccatcctggc tgagtcctcg       60

cagtccccgg cagatcttga agaaaagaag gaagaagaca gcaacatgaa gagagagcag      120

cccagagagc gtcccagggc ctgggactac cctcatggcc tggttggttt acacaacatt      180

ggacagacct gctgccttaa ctccttgatt caggtgttcg taatgaatgt ggacttcacc      240

aggatattga agaggatcac ggtgcccagg ggagctgacg agcagaggag aagcgtccct      300

ttccagatgc ttctgctgct ggagaagatg caggacagcc ggcagaaagc agtgcggccc      360

ctggagctgg cctactgcct gcagaagtgc aacgtgccct tgtttgtcca acatgatgct      420

gcccaactgt acctcaaact ctggaacctg attaaggacc agatcactga tgtgcacttg      480

gtggagagac tgcaggccct gtatacgatc cgggtgaagg actccttgat ttgcgttgac      540

tgtgccatgg agagtagcag aaacagcagc atgctcaccc tcccactttc tctttttgat      600

gtggactcaa agcccctgaa gacactggag gacgccctgc actgcttctt ccagcccagg      660

gagttatcaa gcaaaagcaa gtgcttctgt gagaactgtg ggaagaagac ccgtgggaaa      720

caggtcttga agctgaccca tttgccccag accctgacaa tccacctcat gcgattctcc      780

atcaggaatt cacagacgag aaagatctgc cactccctgt acttccccca gagcttggat      840

ttcagccaga tccttccaat gaagcgagag tcttgtgatg ctgaggagca gtctggaggg      900

cagtatgagc tttttgctgt gattgcgcac gtgggaatgg cagactccgg tcattactgt      960

gtctacatcc ggaatgctgt ggatggaaaa tggttctgct tcaatgactc caatatttgc     1020

ttggtgtcct gggaagacat ccagtgtacc tacggaaatc ctaactacca ctggcaggaa     1080

actgcatatc ttctggttta catgaagatg gagtgctaa                            1119


<210>  572
<211>  2892
<212>  DNA
<213>  Homo sapiens;

<400>  572
atggcggaag gtggaggctg ccgtgagcga ccggatgcgg agactcagaa gtccgagctt       60

ggacccttaa tgaggaccac actccaacgc ggggcgcagt ggtatcttat tgacagccgg      120

tggttcaagc agtggaagaa gtatgtgggc tttgacagct gggacatgta caatgtgggt      180

gaacataacc tatttcctgg cccaatagac aactctgggc tattttcaga tcctgagagt      240

cagaccttga aagaacactt aattgatgaa ttggactatg tattggtccc taccgaggcg      300

tggaataaac tactaaactg gtacggctgt gtagaaggcc agcaacccat cgtcagaaaa      360

gttgtggagc atggcctgtt tgtcaagcac tgcaaagtcg aggtgtattt gctggaactg      420

aagctctgtg agaacagtga ccccaccaat gtgctgagtt gccatttcag caaggcagac      480

accattgcaa ccatcgagaa agagatgcgg aagctattca acatccctgc ggagcgtgaa      540

acacggctct ggaacaaata catgagcaac acctacgagc agttgagcaa gctagacaac      600

actgtccagg atgctgggct ataccagggt caggtgctag taattgagcc tcaaaatgaa      660

gatggcacat ggcccaggca gaccttgcag tcaaaatcaa gcactgcgcc tagcagaaat      720

tttactacct ctccaaaatc atcagcaagt ccctattcct cagtgtctgc ctctctcatt      780

gcaaatggtg atagcactag cacctgtggg atgcacagtt ccggtgtcag caggggtgga      840

tctggctttt ctgcttcgta taattgtcag gagccaccat cctctcatat acaacctggg      900

ctctgtggac ttggaaacct gggaaacacc tgcttcatga actccgcttt gcagtgtttg      960

agcaacactg caccactgac tgactacttt ctcaaagatg agtatgaagc cgaaatcaac     1020

agagacaacc ctctggggat gaaaggggaa attgcagaag cctatgctga actcattaag     1080

cagatgtggt ctggaaggga cgcccatgtg gcacctcgca tgttcaaaac tcaagtagga     1140

cgttttgctc ctcaattttc tggctaccag caacaagatt ctcaggagct gctggccttt     1200

cttctagatg gattgcatga agatctgaac cgggtaaaga aaaagcccta cttggagctg     1260

aaggatgcca atgggcggcc agatgcggtg gtggcaaagg aagcctggga gaatcacagg     1320

ttgaggaatg attctgtgat tgtggatact ttccatggcc tcttcaaatc tactttggtt     1380

tgcccagaat gtgctaaggt ttctgtgacc tttgacccat tttgctatct aacgctgcca     1440

ctgcccttga agaaagatcg agttatggag gttttcctgg ttcctgctga ccctcactgc     1500

agacctactc agtaccgtgt gactgtgccg ctgatggggg ctgtgtccga cctgtgcgag     1560

gctctctcca ggctgtctgg cattgctgca gaaaatatgg tggtcgcaga tgtgtataat     1620

caccgattcc acaaaatttt ccaaatggat gaaggtttaa accacatcat gcctcgggat     1680

gacattttcg tgtacgaggt ctgcagcact tccgtggatg gctcggaatg tgtcacgctt     1740

ccagtctact tcagggagag gaagtccagg ccatcaagca cttcctccgc atcagcgcta     1800

tatgggcagc cactattgct ttctgtcccc aagcacaagt taacccttga gtctttgtac     1860

caggctgttt gtgatcgtat cagccgctat gtgaaacagc ctttacctga tgagtttggc     1920

agctcaccct tggagccagg ggcctgcaat ggctccagga acagctgtga aggagaagat     1980

gaggaagaaa tggagcatca ggaagaaggc aaagagcagc tttcagaaac agaaggcagt     2040

ggggaagatg agccaggaaa tgaccccagt gagaccaccc aaaagaagat caaaggccag     2100

ccctgcccaa aaaggctttt taccttcagt cttgtgaact cctatggaac agctgacata     2160

aattcacttg cagctgatgg aaaactactt aaactcaact ctcgatctac actggccatg     2220

gattgggaca gtgaaactcg gagactttac tatgatgagc aagaatctga ggcctacgag     2280

aagcatgtga gcatgttgca gcctcagaag aagaagaaga ccacagtggc cctgagagac     2340

tgcatcgagc tcttcaccac catggagacc cttggggagc atgacccctg gtactgtccc     2400

aactgtaaga agcatcaaca ggccacaaaa aagtttgacc tatggtcctt gcccaagatc     2460

ctggtggtcc acctcaaacg tttctcctac aacagatact ggagggataa gctcgacaca     2520

gtcgtagaat tcccaatcag agggctgaac atgtccgagt ttgtctgtaa cctgtcagca     2580

aggccttatg tgtacgacct cattgccgtg tccaatcatt atggagccat gggggttggc     2640

cactacactg catatgcgaa gaacaaactg aatggtaaat ggtattactt tgatgatagc     2700

aacgtgtccc tggcctctga ggatcagata gtgactaaag cagcttatgt gctattttac     2760

caacgtcgag atgatgaatt ttataagaca ccttcactta gcagttctgg ttcctctgat     2820

ggagggacac gaccaagcag ctctcagcag ggctttgggg atgatgaggc ttgcagcatg     2880

gacaccaact aa                                                         2892


<210>  573
<211>  2316
<212>  DNA
<213>  Homo sapiens;

<400>  573
atgactgcga accggcttgc agagagcctt ctggctttga gccaacagga agaactagcg       60

gatttgccaa aagactacct cttgagtgag agtgaagatg agggggacaa tgatggagag      120

agaaagcatc aaaagcttct ggaagcaatc agttcccttg atggaaagaa taggcggaaa      180

ttggctgaga ggtctgaggc tagtctgaag gtgtcagagt tcaatgtcag ttctgaagga      240

tcaggagaaa agctggtcct tgcagatctg cttgagcctg ttaaaacttc atcttctttg      300

gccactgtga aaaagcaact gagtagagtc aaatcaaaga agacagtgga gttacctctg      360

aacaaagaag agattgaacg gatccacaga gaagtagcat tcaataaaac cgcacaagtc      420

ctctccaaat gggaccctgt cgtcctgaag aaccggcagg cagagcagct ggtttttccc      480

ctggagaaag aggagccagc cattgctccc attgaacatg tgctcagtgg ctggaaggca      540

agaactcccc tggagcagga aattttcaac ctcctccata agaacaagca gccagtgaca      600

gaccctttac tgacccctgt ggaaaaggcc tctctccgag ccatgagcct agaagaggca      660

aagatgcgac gagcagagct tcagagggct cgggctctgc agtcctacta tgaggccaag      720

gctcgaagag agaagaaaat caaaagtaaa aagtatcaca aagtcgtgaa gaaaggaaag      780

gccaagaaag ccctaaaaga gtttgagcag ctgcggaagg ttaatccagc tgcagcacta      840

gaagaactgg aaaaaattga aaaggccaga atgatggaaa gaatgagcct taagcaccaa      900

aacagtggga aatgggccaa gtcaaaggca attatggcca aatatgacct ggaggctcgc      960

caagctatgc aggaacagtt gtctaagaac aaagaactga cacagaaact ccaggtagcc     1020

tctgagagtg aggaagagga gggaggcaca gaagatgtgg aagaactcct tgtccctgat     1080

gtagtgaatg aagtgcagat gaatgcagat gggccgaatc cctggatgct caggagctgc     1140

accagtgaca ccaaagaggc tgcaacccag gaggaccctg agcaactgcc agagcttgag     1200

gcccatggag tttctgaaag tgagggagaa gaaagaccag tggcagaaga agaaattttg     1260

ttgagagaat ttgaggaaag gcgatccctt agaaaaagat ctgagctcag ccaagatgct     1320

gagccagcag gcagtcaaga aacaaaagat tctggcagcc aggaggtgct gtctgaattg     1380

agagtactat ctcagaaatt gaaggaaaac catcagtcca ggaagcaaaa agcaagttca     1440

gaggggacta ttccccaggt ccagagagag gaacctgccc cagaagaaga ggagcccctg     1500

ttgctacaga gaccagagag agtacagacg ctggaagagc tagaagagct gggaaaagaa     1560

gaatgttttc aaaataagga gcttcccaga cctgtgttag aagggcagca gtcagagagg     1620

accccaaata atcgccctga tgcccctaag gagaagaaaa agaaggagca aatgatcgac     1680

ctacagaacc tcctaaccac acaatctccc tccgtgaagt ctttggcagt tcccacaata     1740

gaggagctgg aagatgaaga ggagagaaac cataggcaga tgataaagga agcttttgct     1800

ggggatgatg tcatcagaga tttcttgaaa gagaagaggg aagctgtgga ggcgagtaag     1860

ccaaaggacg tggacctgac actacctggc tggggcgagt ggggtggtgt gggcctaaag     1920

cccagtgcca agaaaagacg ccggtttctc attaaagccc ctgagggtcc tccaagaaaa     1980

gataagaatt tgccaaatgt gattatcaat gagaagcgca acatccacgc agctgctcat     2040

caggtacgag tgcttccata tccatttacc caccattggc aatttgaaag gaccatccag     2100

acccccatag gatccacatg gaacacccag agggctttcc aaaagctgac tactcccaag     2160

gtcgtcacca agccaggcca tatcattaac cccataaaag cagaagacgt gggctaccgg     2220

tcttcctcaa ggtcggacct gtctgtcata cagaggaatc caaaacgaat caccacacgt     2280

cacaaaaaac agctgaagaa atgctctgta gattga                               2316


<210>  574
<211>  303
<212>  DNA
<213>  Homo sapiens;

<400>  574
atgtctacag gtccaactgc tgccactggc agtaatcgaa gacttcagca gacacaaaat       60

caagtagatg aggtggtgga cataatgcga gttaacgtgg acaaggttct ggaaagagac      120

cagaagctct ctgagttaga cgaccgtgca gacgcactgc aggcaggcgc ttctcaattt      180

gaaacgagcg cagccaagtt gaagaggaaa tattggtgga agaattgcaa gatgtgggca      240

atcgggatta ctgttctggt tatcttcatc atcatcatca tcgtgtgggt tgtctcttca      300

tga                                                                    303


<210>  575
<211>  2544
<212>  DNA
<213>  Homo sapiens;

<400>  575
atggagccgt ggaagcagtg cgcgcagtgg ctcatccatt gcaaggtgct gcccaccaac       60

caccgggtga cctgggactc ggctcaggtg ttcgaccttg cgcagaccct ccgcgatgga      120

gtcctgctct gccagctgct taacaacctc cgggcgcact ccatcaacct gaaggagatc      180

aacctgaggc cgcagatgtc ccagtttctc tgtttgaaga acataaggac atttctcacg      240

gcctgttgtg agacgtttgg aatgaggaaa agtgaacttt tcgaggcatt tgacttgttt      300

gatgttcgtg actttggaaa ggttatagaa acattatcac gactttctcg aacacctata      360

gcattggcca caggaatcag gcccttccca acagaagaaa gcattaatga tgaagacatc      420

tacaaaggcc ttcctgattt aatagatgaa acccttgtgg aagatgaaga agatctctat      480

gactgtgttt atggggaaga tgaaggtgga gaagtctatg aggacttaat gaaggcagag      540

gaagcacatc agcccaaatg tccagaaaat gatatacgaa gttgttgtct agcagaaatt      600

aagcagacag aagaaaaata tacagaaact ttggagtcaa tagaaaagta tttcatggca      660

ccactaaaaa gatttctgac agcagcagaa tttgattcag tattcatcaa cattcctgaa      720

cttgtaaaac ttcatcggaa cctaatgcaa gagattcatg attccattgt aaataaaaat      780

gaccagaact tgtaccaagt ttttattaac tacaaggaaa gattggttat ttacgggcag      840

tactgcagtg gagtggagtc agccatctct agtttagact acatttctaa gacaaaagaa      900

gatgtcaaac tgaaattaga ggaatgttcc aaaagagcaa ataatgggaa atttactctt      960

cgagacttgc ttgtggttcc tatgcaacgt gttttaaagt accaccttct cctccaggaa     1020

ctggtcaaac ataccactga tccgactgag aaggcaaatc tgaaactggc tcttgatgcc     1080

atgaaggact tggcacaata tgtgaatgaa gtgaaaagag ataatgagac ccttcgtgaa     1140

attaaacagt ttcagctatc tatagagaat ttgaaccaac cagttttgct ttttggacga     1200

cctcagggag atggtgaaat tcgaataacc actctagaca agcataccaa acaagaaagg     1260

catatcttct tatttgattt ggcagtgatc gtatgtaaga gaaaaggtga taactatgaa     1320

atgaaggaaa taatagatct tcagcagtac aagatagcca ataatcctac aaccgataaa     1380

gaaaacaaaa agtggtctta tggcttctac ctcatccata cccaaggaca aaatgggtta     1440

gaattttatt gcaaaacaaa agatttaaag aagaaatggc tagaacagtt tgaaatggct     1500

ttgtctaaca taagaccaga ctatgcagac tccaatttcc acgacttcaa gatgcatacc     1560

ttcactcgag tcacatcctg caaagtctgc cagatgctcc tgaggggaac attttatcaa     1620

ggctatttat gttttaagtg tggagcgaga gcacacaaag aatgtttggg aagagtagac     1680

aattgtggca gagttaattc tggtgaacaa gggacactca aactaccaga gaaacggacc     1740

aatggactgc gaagaactcc taaacaggtg gatccaggtt taccaaagat gcaggtcatt     1800

aggaactatt ctggaacacc acccccagct ctgcatgaag gacccccttt acagctccag     1860

gccggggata ccgttgaact tctgaaagga gatgcacaca gtctgttttg gcagggcaga     1920

aatttagcat ctggagaggt tggatttttt ccaagtgatg cagtcaagcc ttgcccatgt     1980

gtgcccaaac cagtagatta ttcttgccaa ccctggtatg ctggagcaat ggaaagattg     2040

caagcagaga ccgaacttat taatagggta aatagtactt accttgtgag gcacaggacc     2100

aaagagtcag gagaatatgc aattagcatt aagtacaata atgaagcaaa gcacatcaag     2160

attttaacaa gagatggctt ttttcacatt gcagaaaata gaaaatttaa aagtttaatg     2220

gaacttgtgg agtactacaa gcatcattct ctcaaggaag ggttcagaac cttagataca     2280

actctgcagt ttccatacaa ggagccagaa cattcagctg gacagagggg taatagagca     2340

ggcaacagct tgttaagtcc aaaagtgctg ggcattgcca tcgctcggta tgacttctgt     2400

gcaagagata tgagagagtt gtccttgttg aaaggagatg tggtgaagat ttacacaaag     2460

atgagtgcaa atggctggtg gagaggagaa gtaaatggca gggtgggctg gtttccatcc     2520

acatatgtgg aagaggatga ataa                                            2544


<210>  576
<211>  1566
<212>  DNA
<213>  Homo sapiens;

<400>  576
atggaggcca actggaccgc gttcctgttc caggcccatg aagcttccca tcaccaacag       60

caggcagcac agaacagctt gctgcccctc ctgagctctg ccgtggagcc ccctgatcag      120

aaaccattgc ttccaatacc aataactcag aaacctcagg gtgcaccaga aacattaaag      180

gatgccattg ggattaaaaa agaaaaaccc aaaacttcat ttgtgtgcac ttactgcagt      240

aaagctttca gggacagcta tcacctgagg cgccacgaat cctgccacac agggatcaag      300

ttggtgtccc ggccaaagaa aacccccacc acggtggttc cccttatctc taccatcgct      360

ggggacagca gccgaacttc gttggtctcg accattgcag gcatcttgtc aacagtcact      420

acatcttcct cgggcaccaa ccccagtagc agtgccagca ccacagctat gccagtgacc      480

cagtctgtca agaaacccag taagcctgtc aagaagaacc atgcttgtga gatgtgtggg      540

aaggccttcc gagatgtgta ccatctcaat cgacacaagc tctcccattc agatgagaaa      600

ccctttgagt gtcctatttg taatcagcgc ttcaagagga aggaccggat gacttaccat      660

gtgaggtctc atgaaggagg catcaccaaa ccctatactt gcagtgtttg tgggaaaggc      720

ttctcaaggc ctgaccactt aagctgtcat gtaaaacatg tccattcaac agaaagaccc      780

ttcaaatgcc aaacgtgcac tgctgccttt gccaccaaag acagactgcg gacacacatg      840

gtgcgccatg aaggcaaggt atcatgtaac atctgtggga agctcctgag tgcagcatac      900

atcaccagcc acttaaagac tcatgggcag agccaaagta tcaactgtaa tacatgtaaa      960

caaggcatca gtaaaacatg catgagtgaa gagaccagta accaaaagca gcagcagcag     1020

cagcagcagc agcagcagca gcagcaacaa caacaacaac aacatgtgac aagctggcca     1080

gggaagcaag tagaaacact gagactgtgg gaagaagctg ttaaagcaag gaagaaagaa     1140

gctgctaacc tgtgccaaac ctccacggct gctacgacac ctgtgactct cactactcca     1200

ttcagtataa catcctctgt gtcgtctggg actatgtcaa acccagtcac agtggcagct     1260

gcaatgagca tgagaagtcc agtaaatgtt tcaagtgcag ttaacataac cagcccaatg     1320

aacatagggc atcctgtaac tataaccagt ccattatcca tgacctctcc tttaacactc     1380

actaccccag tcaacctccc cacccccgtc actgccccag tgaatatagc acaccctgtc     1440

accatcacat ctccaatgaa tctacccaca cctatgacat tagccgcccc tctcaatata     1500

gcaatgagac ctgtagagag catgcctttc ttgccccaag ctttgcctac atcaccgcct     1560

tggtaa                                                                1566


<210>  577
<211>  4281
<212>  DNA
<213>  Homo sapiens;

<400>  577
atggaaaatg aaccagacca tgaaaatgtg gaacagagcc tctgtgccaa gacgagcgaa       60

gaagagctga ataagtcttt caatctagaa gcttcacttt caaaattctc ttacatagat      120

atggacaagg aactggagtt caaaaatgat ctgattgatg acaaggagtt tgatattcct      180

caagttgata ctcctccaac actggaaagc atactaaatg agactgatga tgaagatgag      240

tcttttattc ttgaggatcc tacattgtta aacattgata ctattgattc tcactcctat      300

gatacttcat ctgtggcaag ctcagatagt ggtgacagga ccaacttaaa aaggaagaag      360

aaattacctg attctttttc acttcatgga tcagttatgc gccattcact tttgaaggga      420

atttctgccc agatagtgtc tgcagctgac aaagtagatg ctggcttgcc tacagcaatt      480

gcagtatcca gtctgatagc agtgggtaca tctcatggat tggctttaat atttgatcag      540

aatcaagctt tgcgactctg tctgggtagc actagtgttg gaggtcagta tggcgctatc      600

tctgccctca gtatcaacaa tgattgctca agacttcttt gtggctttgc taaaggacag      660

atcaccatgt gggatttggc cagtggaaaa cttctaagat caataacaga tgctcatcct      720

ccaggaacag caatattgca tatcaagttt acagatgatc caactcttgc aatttgcaac      780

gacagcggag gctctgtttt tgaattgaca tttaagagag tgatgggagt gagaacctgt      840

gaatctagat gtctgttcag tggttccaag ggtgaagtct gctgtattga gcctctgcat      900

tctaagcctg agttgaaaga tcatcccatc acacagtttt cattattggc catggcatcc      960

ttgacaaaaa tactggtcat tggattgaaa ccatccttga aagtatggat gacttttccc     1020

tatggccgga tggatccttc cagtgtgcca ctgctggcct ggcactttgt agcagtacaa     1080

aattacgtga atcccatgct tgccttctgc agaggagatg ttgttcattt tctattggta     1140

aagagagatg aatctggagc aatacatgtt actaagcaaa agcatcttca cctatactat     1200

gacctcatca actttacctg gataaattca cgcacagttg tgctcttaga cagcgtagag     1260

aagttgcatg tgattgatcg gcaaacacaa gaggaattgg agacagtgga gatctcagaa     1320

gttcagctgg tctacaatag cagccatttc aaatcactag ccactggagg aaatgttagc     1380

caggcactgg ctttggttgg agagaaggct tgttatcaat ccatcagtag ctatggtggt     1440

cagatctttt atttggggac aaaatctgtt tatgtgatga tgctgaggag ctggagagag     1500

agagtggatc atctcctgaa acaagattgt cttacagaag cgttggctct tgcgtggtct     1560

ttccatgaag gaaaagcaaa agcagtagtg ggattatcag gggatgccag taagcgaaag     1620

gctattgttg cagaccggat ggtagaaatc ctattccatt atgcagatcg agctctgaaa     1680

aagtgcccag accaaggaaa aatccaagtg atggagcagc attttcagga tatggtgcct     1740

gtcatagttg attactgcct tctgctgcag cgaaaggatc ttttatttag tcagatgtat     1800

gataaattaa gtgagaattc agtggccaaa ggagtatttt tggagtgcct tgagccatat     1860

attttaagtg ataaattggt gggaatcaca ccccaagtaa tgaaagactt gattgttcat     1920

ttccaagata aaaaattaat ggaaaatgtg gaagcgctca ttgtacatat ggatatcacc     1980

agcctagata ttcagcaggt agttctcatg tgttgggaaa atcgtttata tgatgctatg     2040

atctatgtct acaacagagg catgaatgaa tttattagtc caatggagaa acttttcaga     2100

gtcattgctc ctcctctgaa tgcaggaaaa acactaacag atgaacaagt tgttatgggc     2160

aataagctcc ttgtatatat tagctgttgt ctagcaggtc gtgcctatcc ccttggtgac     2220

atccctgaag atctggttcc cttggttaaa aaccaggttt ttgaatttct aattcgcctg     2280

cattcagcag aggcttctcc tgaggaagaa atctatcctt acattcggac tttgctacat     2340

tttgacacaa gagaatttct aaatgtattg gcactgactt ttgaagattt taaaaatgac     2400

aagcaagctg tggaatatca acagcgaatt gtggatattt tgttgaaagt tatggtggag     2460

aattcagact ttaccccctc acaagtagga tgtctcttta ccttccttgc tcggcagctt     2520

gcaaagcctg acaacacctt gtttgtaaac agaacacttt ttgatcaggt ccttgaattc     2580

ctttgtagtc ctgacgatga ctcccgacac tctgaaagac agcaggtcct tttagaattg     2640

ctgcaggctg gaggcatagt tcaatttgaa gagagtcgac tcatccggat ggcagaaaaa     2700

gctgagttct atcaaatttg tgaatttatg tatgaaagag aacaccaata tgataaaatt     2760

attgattgct acttacgtga ccctctgcga gaggaagaag tctttaatta cattcacaat     2820

atcttatcca ttcccggaca cagtgcagag gagaagcagt ctgtatggca gaaagcaatg     2880

gatcatattg aggaactcgt gtccctgaag ccttgtaaag ctgcggagct ggttgccacc     2940

cacttttctg gacatattga aacggtcatt aaaaaacttc agaaccaggt tttgcttttc     3000

aaatttttga ggagtcttct tgacccaagg gaaggtattc atgtaaatca agaattactg     3060

caaatatctc cttgtatcac agagcagttc attgagctgt tgtgtcagtt caacccaacc     3120

caagttatag agactctgca agtccttgag tgctaccgtc tggaagaaac tattcagatt     3180

actcagaagt atcaacttca tgaagtcacc gcttatctat tggaaaagaa aggagatatt     3240

catggtgcct tcctaataat gttagagaga ctacaaagca aacttcaaga ggtaacacat     3300

caaggtgaaa ataccaaaga ggatccctca ttgaaggatg ttgaagatac tatggtggag     3360

accattgctc tttgccagag aaattcacat aatttgaacc agcagcaacg tgaggcactt     3420

tggtttccgt tattggaggc aatgatggcc cctcagaagc tgtccagttc agccattcct     3480

catctacact ctgaagctct gaagtctttg accatgcaag ttttaaatag catggcagca     3540

tttattgccc ttccatcaat cttgcaaaga atcttacagg atccagttta tggaaaagga     3600

aaacttggag aaatccaggg acttatcttg ggaatgttag atacctttaa ctatgaacaa     3660

accctgctgg aaacaacaac cagccttcta aaccaagatc tccattggtc attgtgtaac     3720

ctgagagctt cggtcaccag aggactgaat cccaaacaag attactgctc tatatgtttg     3780

cagcagtaca agagacgcca agaaatggct gatgaaataa ttgtctttag ctgtggccat     3840

ttgtatcact cattctgcct acaaaacaaa gaatgcactg tggaatttga gggccaaaca     3900

agatggacat gctacaaatg cagttcaagt aacaaagtag gaaaactcag tgaaaattca     3960

tctgaaatta aaaagggaag gataacccca tcacaggtaa aaatgtctcc atcgtatcat     4020

cagtccaaag gggatcccac tgctaaaaag ggaacctcag aacctgttct ggatccacag     4080

caaatccaag catttgatca gctttgccgt ctctaccgag gaagctccag gctggctctc     4140

ctcacggaac tctcccagaa tcgcagcagc gagagctata ggccattcag tggctcgcag     4200

agtgctcctg ctttcaacag catcttccag aatgagaact tccagctgca gctcattcct     4260

ccacctgtga ctgaggattg a                                               4281


<210>  578
<211>  1497
<212>  DNA
<213>  Homo sapiens;

<400>  578
atgccgttag taacgaggaa catcgagcca aggcacctgt gccgtcagac gttgcctagc       60

gttagaagcg agctggaatg cgtgaccaac atcaccctgg caaatgtcat ccgacagctg      120

ggcagcctga gtaaatatgc agaggacatt tttggagagc tctttactca ggcaaatacc      180

tttgcctctc gggtaagctc ccttgctgag agggtcgacc gactacaggt taaagtcact      240

cagctggatc ccaaggaaga agaagtgtca ctgcaaggaa tcaacacccg aaaagccttc      300

agaagttcca ccattcaaga ccagaagctt tttgacagaa actctctccc agtgcctgtc      360

ttagaaacat acaatacctg tgatactcct ccccctctca acaatcttac cccttacagg      420

gacgatggaa aagaggcact caaattctac acagaccctt catacttctt tgatctttgg      480

aaggagaaga tgctgcagga caccaaggat atcatgaaag agaagagaaa gcataggaaa      540

gaaaagaaag ataatccaaa tcgagggaat gtaaacccac gtaaaatcaa gacacgtaag      600

gaagagtggg agaaaatgaa gatggggcaa gaatttgtgg agtccaaaga aaagctgggg      660

acttctgggt atccacccac tttggtgtac cagaatggca gcattggctg tgttgaaaac      720

gtggatgcaa gtagctatcc gccaccacca cagtcagact ctgcttcttc accttctcct      780

tccttctccg aggacaactt gcctcctcca ccagcagaat tcagttaccc agtggacaac      840

caaagaggat ctggtttggc tggacccaaa agatccagtg tggtcagccc aagccatcca      900

ccaccagctc ctcctctagg ctctccacca ggccctaaac ccgggtttgc tccaccacct      960

gcccctccgc cacctccgcc tccaatgata ggcatcccac ctccaccacc gcctgtagga     1020

tttgggtctc cagggacgcc tccaccaccc tcacccccat ctttcccacc tcaccctgat     1080

tttgctgccc ctccacctcc tcctccacca ccagcagctg actacccaac tctgccacca     1140

cctcccttgt cccagccaac aggaggagca cctcctcctc cccctcctcc tcctcctccg     1200

gggccccctc ctcccccttt cactggtgca gatggccagc ctgctatacc accaccgctt     1260

tctgatacca ccaagcccaa gtcctccttg cctgccgtga gcgatgcccg tagcgacctg     1320

ctttcagcca tccgtcaagg ttttcagctg cgcagggttg aggagcagcg ggaacaagag     1380

aagcgggatg ttgtgggcaa tgacgtggcc accatcttgt ctcgtcgcat tgctgttgag     1440

tacagtgact cagaagatga ctcctctgaa tttgatgagg acgactggtc cgattaa        1497


<210>  579
<211>  786
<212>  DNA
<213>  Homo sapiens;

<400>  579
atggcgctca acaagaatca ctcggagggc ggcggagtga tcgtcaataa caccgagagc       60

atcctaatgt cctatgatca cgtggaactc acattcaatg acatgaagaa cgtgccagaa      120

gccttcaaag ggaccaagaa aggcactgtc taccttaccc cttaccgggt catctttctg      180

tccaagggca aggatgccat gcagtccttc atgatgccat tttatctcat gaaagactgt      240

gagatcaagc agcccgtatt tggtgcaaac tacatcaagg gaacagtgaa ggcggaagcg      300

ggaggtggct gggaaggctc tgcttcctac aagttgactt tcacggcagg gggcgccatt      360

gagttcggac agcggatgct ccaggtggca tctcaagcct ccagaggtga agtccccagt      420

ggagcctatg gctactctta catgcccagc ggggcctatg tctatccccc gccagtcgcc      480

aatggaatgt acccctgccc tcctggctac ccctatccac cgcccccacc tgagttctat      540

ccaggacccc ccatgatgga cggggccatg ggatacgtgc agcccccacc accgccctac      600

cctgggccca tggaacctcc ggtcagcggc cccgatgtcc cctccactcc tgcagccgaa      660

gccaaggccg cagaagcagc cgccagcgcc tattacaacc caggcaatcc tcacaacgtc      720

tacatgccca cgagccagcc gccgccacct ccctactacc caccggaaga taagaagacc      780

cagtag                                                                 786


<210>  580
<211>  1485
<212>  DNA
<213>  Homo sapiens;

<400>  580
atgcccacag aaagcgcaag ttgttcgact gctcgccaaa caaaacagaa gcgcaaatcc       60

catagccttt ctatacgaag aactaacagc tcggagcagg agaggacggg actgccaaga      120

gacatgttag aaggacaaga ttctaaactg ccttcctcgg ttcgcagtac acttctggaa      180

ctgtttggtc aaatagaaag agaatttgaa aacctttata tcgaaaactt agaattacgt      240

agagaaatcg acactcttaa tgaacgttta gctgctgaag gacaagcgat tgatggagca      300

gagctgagta agggccaact caaaacaaaa gccagtcaca gcaccagcca gctctcccag      360

aaactgaaga ccacttacaa ggcttccacc agcaagattg tctccagctt taagaccacg      420

acatcgagag ctgcctgcca gctcgtgaag gagtacatcg gccaccggga cggcatctgg      480

gatgtcagcg tggccaagac acagccagtg gtgctcggga ctgcatcagc cgatcacacg      540

gctttgctgt ggagcataga gacagggaag tgcctagtca agtacgcagg ccacgtgggc      600

tcagtaaatt ctatcaaatt tcatccctca gagcagttgg ctctcactgc ttctggagat      660

cagactgctc atatctggag atacgcggtg cagctgccga caccccagcc tgttgctgac      720

actagtatat ctggggaaga tgaagtagag tgctctgaca aggacgagcc cgacctcgat      780

ggggatgtgt ccagcgactg ccccaccatc cgcgtcccac tgacatccct caagagccac      840

cagggcgtgg tcatcgcctc cgactggctg gttgggggga agcaggctgt gactgcctcc      900

tgggaccgga cggcaaacct gtacgacgtg gagacgtccg agctcgttca ctctctgaca      960

gggcacgacc aggagttgac gcactgctgc acacacccca cccagcggct cgtggtgacc     1020

tcctcccgtg acacgacttt ccgcctctgg gatttcaggg acccctccat ccactcggtg     1080

aatgttttcc agggacacac ggacactgtg acttctgccg tgttcaccgt gggagacaac     1140

gtggtttcag gcagcgatga ccgcacggtg aaagtctggg acttgaaaaa tatgagatcc     1200

cccattgcaa ctattcgcac ggactctgcc attaacagga tcaatgtatg tgtcggccaa     1260

aaaatcatag ccctccccca tgacaaccga caagtgagac tgtttgatat gtcaggagtg     1320

cgcctggcgc ggcttccccg gagcagccga cagggccaca ggagaatggt atgctgctcg     1380

gcatggagtg aagaccaccc cgtgtgcaat ctgttcacct gtgggtttga ccggcaagcc     1440

attggttgga acatcaacat ccctgcattg ctacaagaaa aataa                     1485


<210>  581
<211>  2763
<212>  DNA
<213>  Homo sapiens;

<400>  581
atgacggctg aagaaacagt gaatgtaaaa gaggttgaaa tcattaagct aattttggac       60

ttcctgaatt caaagaagct tcacattagt atgctggccc tggagaagga aagtggagtc      120

ataaatggcc tgttttcaga tgatatgctt ttcctgaggc agctaatact tgatggtcaa      180

tgggatgaag ttcttcagtt cattcagcct ctagaatgta tggaaaaatt tgacaaaaaa      240

aggtttcgtt atattatcct gaagcagaag tttttagaag ctttatgtgt taacaacgcg      300

atgtcagcag aagatgagcc ccagcatctg gaatttacca tgcaagaagc tgtgcaatgt      360

ttacatgctc tagaagaata ctgtccttct aaagatgact atagtaagct ctgtttgctt      420

ttgactttgc ctcgtctgac caatcatgcc gagtttaagg actggaatcc cagcaccgca      480

cgagttcact gttttgaaga ggcttgtgtc atggttgcag aattcatccc tgctgatagg      540

aagctaagtg aagctggttt taaggctagt aacaatcgtt tatttcagct tgtaatgaaa      600

ggcctgcttt atgaatgctg tgtagaattt tgtcagagta aagcaactgg agaagaaatt      660

acagaaagcg aagtgcttct tggcatcgac ctcttatgtg gtaatggttg tgatgatttg      720

gatctgagtt tactgtcatg gcttcagaat cttccatctt ctgtcttctc ttgtgctttt      780

gaacagaaaa tgcttaatat tcatgttgac aaacttctga aacctacaaa agctgcatat      840

gctgatcttt tgactcctct tatcagcaaa ctctctccct atccatcatc cccaatgaga      900

agacctcaat cagctgatgc ctatatgacc cgctctctga atcctgcttt agatggcctc      960

acctgtggac taaccagtca tgataagaga atttcagacc ttggaaacaa aacttctcca     1020

atgtcacact cctttgctaa cttccattat ccaggggtac aaaacctcag tagaagtctc     1080

atgcttgaga atacagaatg tcacagtatt tacgaagaat cccctgagcg aagtgataca     1140

cctgttgatg cacagaggcc tatcggcagt gaaatcttgg gccagagttc agtttcagaa     1200

aaagagcctg caaatggagc acagaatcca ggaccagcta aacaagaaaa aaatgagctt     1260

cgagattcaa cagaacaatt tcaagaatat tataggcaaa gattacgcta tcaacagcat     1320

ttagaacaga aggagcaaca gcggcagata taccaacaga tgttgcttga aggaggcgtg     1380

aatcaggagg atggtcctga tcagcagcag aatcttactg aacagttcct taataggtcc     1440

attcaaaagc ttggtgaatt aaatattgga atggatggcc ttggtaatga ggtatcagca     1500

ctcaaccagc aatgtaatgg gagcaaaggc aatggatcta atggttcttc tgtgactagt     1560

tttactacac caccccaaga ctctagtcag agattaacac atgatgcttc aaatattcat     1620

acaagcactc ctcgtaatcc tggatcaaca aatcacatac cttttctgga ggaatcacct     1680

tgtggaagcc aaatctcttc agaacattcg gtcattaagc cacctcttgg agattctcca     1740

gggagtcttt caaggtcgaa aggggaagag gatgacaaat caaaaaagca gtttgtttgt     1800

attaatatcc tagaagacac acaagctgtt agagcagtgg cttttcatcc agctggaggt     1860

ttatatgctg ttggttcaaa ttcaaaaact ctgagagtat gtgcctatcc agatgtaatt     1920

gatccaagtg cacatgagac tcctaagcag ccggtggtac gttttaaaag gaataaacat     1980

cataaaggat ccatttactg tgtggcctgg agtccttgtg ggcagttatt agcaacagga     2040

tcaaatgaca aatacgtcaa agtgctgccc ttcaatgcag agacttgtaa cgcaacagga     2100

ccagatctgg aatttagtat gcatgatgga acaattagag acttggcatt tatggaaggc     2160

ccagaaagcg gaggagctat tttaataagt gctggagcag gggattgtaa catttataca     2220

accgattgtc aaagaggaca gggcctccat gctttgagtg gacatactgg gcatatttta     2280

gcactttata cctggagtgg ctggatgatt gcatctggtt cccaagataa gactgttaga     2340

ttttgggatc ttcgagtacc aagttgtgtt cgtgttgttg gcacaacatt tcatggaact     2400

ggcagtgcag tggcatctgt agctgtagat cccagtggtc gtctcttagc cacaggtcaa     2460

gaagattcta gctgcatgtt gtatgacata agaggaggaa gaatggtaca aagttatcat     2520

cctcattcca gtgatgttcg ctctgttcga ttctcccctg gagctcacta cttgctaaca     2580

ggctcttatg atatgaaaat aaaggtgaca gacctacaag gggacctcac caagcagctt     2640

cctatcatgg tggtggggga gcacaaggac aaagtgattc agtgcagatg gcacacccag     2700

gatctttcct tcctgtcatc ctctgcagat agaactgtca ccctctggac ttacaatggg     2760

tag                                                                   2763


<210>  582
<211>  906
<212>  DNA
<213>  Homo sapiens;

<400>  582
atggaaggag acttctcggt gtgcaggaac tgtaaaagac atgtagtctc tgccaacttc       60

accctccatg aggcttactg cctgcggttc ctggtcctgt gtccggagtg tgaggagcct      120

gtccccaagg aaaccatgga ggagcactgc aagcttgagc accagcaggt tgggtgtacg      180

atgtgtcagc agagcatgca gaagtcctcg ctggagtttc ataaggccaa tgagtgccag      240

gagcgccctg ttgagtgtaa gttctgcaaa ctggacatgc agctcagcaa gctggagctc      300

cacgagtcct actgtggcag ccggacagag ctctgccaag gctgtggcca gttcatcatg      360

caccgcatgc tcgcccagca cagagatgtc tgtcgcagtg aacaggccca gctcgggaaa      420

ggggaaagaa tttcagctcc tgaaagggaa atctactgtc attattgcaa ccaaatgatt      480

ccagaaaata agtatttcca ccatatgggt aaatgttgtc cagactcaga gtttaagaaa      540

cactttcctg ttggaaatcc agaaattctt ccttcatctc ttccaagtca agctgctgaa      600

aatcaaactt ccacgatgga gaaagatgtt cgtccaaaga caagaagtat aaacagattt      660

cctcttcatt ctgaaagttc atcaaagaaa gcaccaagaa gcaaaaacaa aaccttggat      720

ccacttttga tgtcagagcc caagcccagg accagctccc ctagaggaga taaagcagcc      780

tatgacattc tgaggagatg ttctcagtgt ggcatcctgc ttcccctgcc gatcctaaat      840

caacatcagg agaaatgccg gtggttagct tcatcaaaag gaaaacaagt gagaaatttc      900

agctag                                                                 906


<210>  583
<211>  2823
<212>  DNA
<213>  Homo sapiens;

<400>  583
atggctcgga aacgcgcggc cggcggggag ccgcggggac gcgaactgcg cagccagaaa       60

tccaaggcca agagcaaggc ccggcgtgag gaggaggagg aggatgcctt tgaagatgag      120

aaacccccaa agaagagcct tctctccaaa gtttcacaag gaaagaggaa aagaggctgc      180

agtcatcctg ggggttcagc agatggtcca gcaaaaaaga aagtggccaa ggtgactgtt      240

aaatctgaaa acctcaaggt tataaaggat gaagccctca gcgatgggga tgacctcagg      300

gactttccaa gtgacctcaa gaaggcacac catctgaaga gaggggctac catgaatgaa      360

gacagcaatg aagaagagga agaaagtgaa aatgattggg aagaggttga agaacttagt      420

gagcctgtgc tgggtgacgt gagagaaagt acagccttct ctcgatctct tctgcctgtg      480

aagccagtgg agatagagat tgaaacgcca gagcaggcga agacaagaga aagaagtgaa      540

aagataaaac tggagtttga gacatatctt cggagggcga tgaaacgttt caataaaggg      600

gtccatgagg acacacacaa ggttcacctt ctctgcctgc tagcaaatgg cttctatcga      660

aataacatct gcagccagcc agatctgcat gctattggcc tgtccatcat cccagcccgc      720

tttaccagag tgctgcctcg agatgtggac acctactacc tctcaaacct ggtgaagtgg      780

ttcattggaa catttacagt taatgcagaa ctttcagcca gtgaacaaga taacctgcag      840

actacattgg aaaggagatt tgctatttac tctgctcgag atgatgagga attggtccat      900

atattcttac tgattctccg ggctctgcag ctcttgaccc ggctggtatt gtctctacag      960

ccaattcctc tgaagtcagc aacagcaaag ggaaagaaac cttccaagga aagattgact     1020

gcggatccag gaggctcctc agaaacttcc agccaagttc tagaaaacca caccaaacca     1080

aagaccagca aaggaaccaa acaagaggaa acctttgcta agggcacctg caggccaagt     1140

gccaaaggga agaggaacaa gggaggcaga aagaaacgga gcaagccctc ctccagcgag     1200

gaagatgagg gcccaggaga caagcaggag aaggcaaccc agcgacgtcc gcatggccgg     1260

gagcggcggg tggcctccag ggtgtcttat aaagaggaga gtgggagtga tgaggctggc     1320

agcggctctg attttgagct ctccagtgga gaagcctctg atccctctga tgaggattcc     1380

gaacctggcc ctccaaagca gaggaaagcc cccgctcctc agaggacaaa ggctgggtcc     1440

aagagtgcct ccaggaccca tcgtgggagc catcgtaagg acccaagctt gccagcggca     1500

tcctcaagct cttcaagcag taaaagaggc aagaaaatgt gcagcgatgg tgagaaggca     1560

gaaaaaagaa gcatagctgg tatagaccag tggctagagg tgttctgtga gcaggaggaa     1620

aagtgggtat gtgtagactg tgtgcacggt gtggtgggcc agcctctgac ctgttacaag     1680

tacgccacca agcccatgac ctatgtggtg ggcattgaca gtgacggctg ggtccgagat     1740

gtcacacaga ggtacgaccc agtctggatg acagtgaccc gcaagtgccg ggttgatgct     1800

gagtggtggg ccgagacctt gagaccatac cagagcccat ttatggacag ggagaagaaa     1860

gaagacttgg agtttcaggc taaacacatg gaccagcctt tgcccactgc cattggctta     1920

tataagaacc accctctgta tgccctgaag cggcatctcc tgaaatatga ggccatctat     1980

cccgagacag ctgccatcct tgggtattgt cgtggagaag cggtctactc cagggattgt     2040

gtgcacactc tgcattccag ggacacgtgg ctgaagaaag caagagtggt gaggcttgga     2100

gaagtaccct acaagatggt gaaaggcttt tctaaccgtg ctcggaaagc ccgacttgct     2160

gagccccagc tgcgggaaga aaatgacctg ggcctgtttg gctactggca gacagaggag     2220

tatcagcccc cagtggccgt ggacgggaag gtgccccgga acgagtttgg gaatgtgtac     2280

ctcttcctgc ccagcatgat gcctattggc tgtgtccagc tgaacctgcc caatctacac     2340

cgcgtggccc gcaagctgga catcgactgt gtccaggcca tcactggctt tgatttccat     2400

ggcggctact cccatcccgt gactgatgga tacatcgtct gcgaggaatt caaagacgtg     2460

ctcctgactg cctgggaaaa tgagcaggca gtcattgaaa ggaaggagaa ggagaaaaag     2520

gagaagcggg ctctagggaa ctggaagttg ctggccaaag gtctgctcat cagggagagg     2580

ctgaagcgtc gctacgggcc caagagtgag gcagcagctc cccacacaga tgcaggaggt     2640

ggactctctt ctgatgaaga ggaggggacc agctctcaag cagaagcggc caggatactg     2700

gctgcctcct ggcctcaaaa ccgagaagat gaagaaaagc agaagctgaa gggtgggccc     2760

aagaagacca aaagggaaaa gaaagcagca gcttcccacc tgttcccatt tgagcagctg     2820

tga                                                                   2823


<210>  584
<211>  3378
<212>  DNA
<213>  Homo sapiens;

<400>  584
atggcatctg aagaagcctc tctcagggca ttggaaagtc tgatgacaga attttttcac       60

gattgtacaa ccaatgaaag aaaacgtgag atagaggagc ttcttaataa ctttgcccag      120

caaataggag cctggagatt ctgcctgtac tttctctcca gcactaggaa tgactatgta      180

atgatgtaca gtttaacagt ttttgagaat ctgatcaata aaatgtggct tggggtccca      240

tctcaggata agatggaaat ccgtagctgt ctgcccaaac tccttttggc tcaccataaa      300

accttacctt actttatccg gaacaagctc tgcaaagtta ttgttgatat tggacgtcag      360

gattggccca tgttctacca cgactttttt actaacattt tacagttgat ccagtcccct      420

gtgacaaccc cccttgggct gatcatgttg aagacaactt cagaagagct ggcttgtccc      480

cgtgaggacc tcagtgtggc tcggaaggag gagttgcgga agctgctact ggaccaggtg      540

cagacagtgc ttgggctact gacaggtatc ttggagactg tctgggacaa acacagtgtt      600

actgctgcca ctccaccacc atccccgacc tcaggagaaa gtggtgactt actgagtaac      660

ctgttgcaga gtcccagttc agccaaactg ttgaatcagc caattcccat ccttgatgtg      720

gagagtgagt atatctgttc cctggctttg gagtgcctgg cccatctctt cagttggatt      780

cctctgtctg ccagcatcac cccatccctc cttaccacca tcttccactt tgcacgattt      840

ggctgtgaca tccgggccag aaagatggcg tcagttaacg gcagcagcca gaactgtgtc      900

tcgggtcagg agcgcggccg gctgggggtc ctggccatgt cctgcatcaa tgaactcatg      960

tccaagaact gtgtgcctat ggaatttgag gagtatttac tgcgtatgtt ccagcagact     1020

ttctacctcc tgcagaaaat caccaaggat aacaatgccc acacagtgaa gagcaggcta     1080

gaagagctcg atgagagcta tatcgagaag tttactgact ttcttcggct ctttgtgagt     1140

gttcacctaa gaagaatcga gtcttactcc cagttccctg tggtggagtt tttgacactt     1200

ttgttcaagt acacatttca tcagcctact catgaaggtt acttctcttg tttggatatc     1260

tggacgctgt ttttggacta tctgacaagt aaaattaaaa gtcgtcttgg agacaaggaa     1320

gcagttctca acaggtacga agatgccctg gtgctcctgc tcacagaggt gttgaatcga     1380

atccagttca gatacaacca agcccagctg gaggagttgg atgatgagac tctggatgac     1440

gatcagcaga cggagtggca gcggtactta cggcagagct tggaggtggt ggccaaagtg     1500

atggagctcc tgcccacgca cgccttctcc acactgttcc ctgttcttca ggacaattta     1560

gaagtttatt tgggattaca acagtttata gtcacttcag ggtcaggaca caggttgaac     1620

atcacggcgg agaacgactg ccggcggctg cactgctccc tgagagactt gagctccctg     1680

ctgcaggccg tgggccgcct ggccgagtac tttatcgggg atgtgtttgc tgcacggttc     1740

aatgatgccc tcacagtcgt ggaaaggttg gtcaaagtca ctctgtacgg atctcagata     1800

aaattgtaca acattgaaac tgctgtgcca tcagtattga aacctgacct cattgatgtg     1860

catgctcagt ccctggctgc gctgcaggct tactctcact ggttagcaca gtattgcagt     1920

gaagttcacc ggcagaacac gcagcagttc gtgacactca tctctactac catggatgca     1980

atcacacctc taatcagcac caaggtccaa gacaagctgc tgctatctgc gtgccactta     2040

ctggtctcac tggccaccac cgtgcggccc gtctttctga tcagcatccc tgcagtgcag     2100

aaagtattca acagaatcac tgatgcctct gccctgcgac ttgtcgataa ggcccaggtg     2160

ttggtgtgcc gagccctctc taacatcttg ctgcttccgt ggccaaacct tccagagaat     2220

gagcagcagt ggcccgtgcg ctccatcaac cacgccagcc tcatctctgc actctcccgg     2280

gactatcgca acctgaagcc cagtgctgtt gccccacaga gaaagatgcc actggatgac     2340

accaaactga ttatccacca gacactcagc gtcttagaag atattgtgga gaatatctcg     2400

ggggagtcca ccaagtctcg acagatttgc taccagtcgc tgcaggaatc tgttcaggtc     2460

tccctggccc tctttccagc ttttatccat cagtcagatg tgactgatga gatgctgagc     2520

ttcttcctca ctctgtttcg aggccttaga gtacagatgg gtgtgccttt cactgagcaa     2580

atcatacaga ctttcctcaa catgtttacc agagagcagt tagccgagag catcctccac     2640

gagggcagca caggctgccg ggtggtggag aagtttctga agatcctgca ggtggtggtc     2700

caggagccag gccaggtgtt caagcccttc ctccccagca tcatcgccct gtgcatggag     2760

caagtgtatc ccatcattgc cgagcgtccc tcccctgatg tgaaggccga gctgtttgag     2820

ctccttttcc ggacgctcca tcacaactgg aggtacttct tcaagtccac cgtgctggcc     2880

agtgtccaga gggggatcgc tgaggagcag atggagaatg agccccagtt cagtgccatc     2940

atgcaggctt tcggacagtc ctttctccag cccgacatcc acctttttaa acaaaatctc     3000

ttctacttgg agactctcaa caccaagcag aagctgtacc acaagaagat cttccggact     3060

gccatgctgt tccagtttgt gaacgtgctg ctccaggtcc tggtccacaa gtcccatgat     3120

cttctgcagg aggagattgg catcgccatc tacaacatgg cctcagtcga ctttgatggc     3180

ttctttgccg ccttcctccc agagttcctg accagctgtg atggtgtgga tgccaaccag     3240

aaaagtgtgc tggggcggaa tttcaagatg gatcgggacc tgccctcatt cacccagaat     3300

gtgcacaggc tggtcaacga cctgcgctac tacagactct gcaacgacag cctgccccct     3360

ggcactgtga agctctag                                                   3378


<210>  585
<211>  366
<212>  DNA
<213>  Homo sapiens;

<400>  585
atgggcagaa ttttccttga tcatatcggt ggtacccgtc tgttttcttg tgcaaactgt       60

gatacgatcc tgaccaaccg ctcagaactc atctccactc gtttcacagg cgccactggc      120

agagcatttc tttttaacaa ggtagttaac ctgcagtaca gtgaagttca agatcgggtc      180

atgctcactg gccgccacat ggttcgagat gtgagctgca aaaactgcaa tagcaaactg      240

ggatggatct atgagtttgc cactgaagac agccagcgat ataaggaagg ccgcgtgatc      300

ctggaacgtg ctctagttcg agagagtgag ggctttgagg agcatgtacc atctgataac      360

tcttga                                                                 366


<210>  586
<211>  1758
<212>  DNA
<213>  Homo sapiens;

<400>  586
atgtcagcca ctagcgtgga tcagagacct aaagggcaag gaaataaagt ttcagtacaa       60

aacggttcga ttcatcaaaa agatgctgta aatgatgatg attttgagcc atacttaagt      120

agccagacaa atcagagtaa cagctatcca ccaatgtcag atccatacat gcctagttac      180

tatgctccat ccattggatt tccatattct cttggggaag cagcgtggtc cacagctgga      240

gaccagccta tgccatatct gacaacctat ggacaaatga gtaatggaga acatcactat      300

ataccagatg gtgtatttag tcaacctggg gcattaggaa atacccctcc atttcttggt      360

caacatggat ttaacttttt tcctggtaat gctgatttct ctacatgggg gacaagtgga      420

tctcagggac aatcaacaca aagttctgct tatagtagca gttatggcta tccacctagt      480

tctcttggga gagctattac tgatggacag gctggatttg gcaatgatac tttgagtaag      540

gtgcctggca ttagcagtat tgagcaaggc atgactggac tgaaaattgg tggtgacctg      600

acagctgcag tgacaaaaac tgtaggtaca gctttgagca gcagtggtat gactagcatt      660

gcaaccaata gtgtgccccc agttagcagt gcagcaccta aaccaacctc ctgggctgcc      720

attgccagaa agcctgccaa acctcaaccg aaacttaaac ccaagggcaa tgtgggaatt      780

gggggttctg ctgtaccacc acctcctata aaacacaaca tgaatattgg aacttgggat      840

gaaaaagggt cagtggtaaa ggctccacca acccaaccag ttctgcctcc tcaaactata      900

atccagcagc ctcagccatt aattcaacca ccaccattgg tgcaaagcca actgcctcaa      960

cagcagcctc aaccaccaca accacagcag caacaaggac ctcagccaca ggcccagcct     1020

caccaagtgc agcctcaaca gcagcagctg cagaatcgct gggtagctcc tcgtaacagg     1080

ggagcaggct tcaaccagaa caatggagcg ggcagtgaaa actttggttt aggtgttgta     1140

cctgtcagtg cttcaccttc tagtgtagaa gtgcatcccg tgctggaaaa gctaaaggcc     1200

ataaacaact ataatcccaa agactttgat tggaatctga agaatggacg tgtgtttata     1260

attaaaagct actctgagga tgacatacat cgttccatta aatactctat ctggtgtagt     1320

actgagcatg gtaataagcg tttggatgca gcttaccgtt ccctgaatgg gaaaggccca     1380

ctctatttac tcttcagtgt gaatggcagt ggacattttt gtggagtggc tgaaatgaag     1440

tctgttgtgg actataatgc gtatgctggt gtctggtctc aggataagtg gaagggcaaa     1500

tttgaagtta aatggatctt tgtcaaagat gttcccaata accaattacg gcatattcgc     1560

ttagaaaata atgacaacaa accggttacc aattcaaggg acactcaaga ggtaccccta     1620

gaaaaagcta agcaagtgct taaaataatt gctactttca agcataccac ctcaatcttt     1680

gatgactttg cacattatga aaagcgtcaa gaagaggagg aagccatgcg tagggagaga     1740

aatagaaaca aacaataa                                                   1758


<210>  587
<211>  1758
<212>  DNA
<213>  Homo sapiens;

<400>  587
atgtcagcca ctagcgtgga tcagagacct aaagggcaag gaaataaagt ttcagtacaa       60

aacggttcga ttcatcaaaa agatgctgta aatgatgatg attttgagcc atacttaagt      120

agccagacaa atcagagtaa cagctatcca ccaatgtcag atccatacat gcctagttac      180

tatgctccat ccattggatt tccatattct cttggggaag cagcgtggtc cacagctgga      240

gaccagccta tgccatatct gacaacctat ggacaaatga gtaatggaga acatcactat      300

ataccagatg gtgtatttag tcaacctggg gcattaggaa atacccctcc atttcttggt      360

caacatggat ttaacttttt tcctggtaat gctgatttct ctacatgggg gacaagtgga      420

tctcagggac aatcaacaca aagttctgct tatagtagca gttatggcta tccacctagt      480

tctcttggga gagctattac tgatggacag gctggatttg gcaatgatac tttgagtaag      540

gtgcctggca ttagcagtat tgagcaaggc atgactggac tgaaaattgg tggtgacctg      600

acagctgcag tgacaaaaac tgtaggtaca gctttgagca gcagtggtat gactagcatt      660

gcaaccaata gtgtgccccc agttagcagt gcagcaccta aaccaacctc ctgggctgcc      720

attgccagaa agcctgccaa acctcaaccg aaacttaaac ccaagggcaa tgtgggaatt      780

gggggttctg ctgtaccacc acctcctata aaacacaaca tgaatattgg aacttgggat      840

gaaaaagggt cagtggtaaa ggctccacca acccaaccag ttctgcctcc tcaaactata      900

atccagcagc ctcagccatt aattcaacca ccaccattgg tgcaaagcca actgcctcaa      960

cagcagcctc aaccaccaca accacagcag caacaaggac ctcagccaca ggcccagcct     1020

caccaagtgc agcctcaaca gcagcagctg cagaatcgct gggtagctcc tcgtaacagg     1080

ggagcaggct tcaaccagaa caatggagcg ggcagtgaaa actttggttt aggtgttgta     1140

cctgtcagtg cttcaccttc tagtgtagaa gtgcatcccg tgctggaaaa gctaaaggcc     1200

ataaacaact ataatcccaa agactttgat tggaatctga agaatggacg tgtgtttata     1260

attaaaagct actctgagga tgacatacat cgttccatta aatactctat ctggtgtagt     1320

actgagcatg gtaataagcg tttggatgca gcttaccgtt ccctgaatgg gaaaggccca     1380

ctctatttac tcttcagtgt gaatggcagt ggacattttt gtggagtggc tgaaatgaag     1440

tctgttgtgg actataatgc gtatgctggt gtctggtctc aggataagtg gaagggcaaa     1500

tttgaagtta aatggatctt tgtcaaagat gttcccaata accaattacg gcatattcgc     1560

ttagaaaata atgacaacaa accggttacc aattcaaggg acactcaaga ggtaccccta     1620

gaaaaagcta agcaagtgct taaaataatt gctactttca agcataccac ctcaatcttt     1680

gatgactttg cacattatga aaagcgtcaa gaagaggagg aagccatgcg tagggagaga     1740

aatagaaaca aacaataa                                                   1758


<210>  588
<211>  1569
<212>  DNA
<213>  Homo sapiens;

<400>  588
atggagtttc cagaccatag tagacatttg ctacagtgtc tgagcgagca gagacaccag       60

ggttttcttt gtgactgcac tgttctggtg ggagatgccc agttccgagc gcaccgagct      120

gtactggctt catgcagcat gtatttccac ctcttttaca aggaccagct ggacaaaaga      180

gacattgttc atctgaacag cgacattgtt acagcccccg ctttcgctct cctgcttgaa      240

ttcatgtatg aagggaaact ccagttcaaa gacttgccca ttgaagacgt gctagcagct      300

gccagttatc tccacatgta tgacattgtc aaagtctgca aaaagaagct gaaagagaaa      360

gccaccacgg aggcagacag caccaaaaag gaagaagatg cttcaagttg ttcggacaaa      420

gtcgagagtc tctccgatgg cagcagccac atagcaggcg atttgcccag tgatgaagat      480

gaaggagaag atgaaaaatt gaacatcctg cccagcaaaa gggacttggc ggccgagcct      540

gggaacatgt ggatgcgatt gccctcagac tcagcaggca tcccccaggc tggcggagag      600

gcagagccac acgccacagc agctggaaaa acagtagcca gcccctgcag ctcaacagag      660

tctttgtccc agaggtctgt cacctccgtg agggattcgg cagatgttga ctgtgtgctg      720

gacctgtctg tcaagtccag cctttcagga gttgaaaatc tgaacagctc ttatttctct      780

tcacaggacg tgctgagaag caacctggtg caggtgaagg tggagaaaga ggcttcctgt      840

gatgagagtg atgttggcac taatgactat gacatggaac atagcactgt gaaagaaagt      900

gtgagcacta ataacagggt acagtatgag ccggcccatc tggctcccct gagggaggac      960

tcggtcttga gggagctgga ccgggaggac aaagccagtg atgatgagat gatgacccca     1020

gagagcgagc gtgtccaggt ggagggaggc atggagagca gtctgctccc ctacgtctcc     1080

aacatcctga gccccgcggg ccagatcttc atgtgccccc tgtgcaacaa ggtcttcccc     1140

agcccccaca tcctgcagat ccacctgagc acgcacttcc gcgagcagga cggcatccgc     1200

agcaagcccg ccgccgatgt caacgtgccc acgtgctcgc tgtgtgggaa gactttctct     1260

tgcatgtaca ccctcaagcg ccacgagagg actcactcgg gggagaagcc ctacacatgc     1320

acccagtgcg gcaagagctt ccagtactcg cacaacctga gccgccatgc cgtggtgcac     1380

acccgcgaga agccgcacgc ctgcaagtgg tgcgagcgca ggttcacgca gtccggggac     1440

ctgtacagac acattcgcaa gttccactgt gagttggtga actccttgtc ggtcaaaagc     1500

gaagcactga gcttgcctac tgtcagagac tggaccttag aagatagctc tcaagaactt     1560

tggaaataa                                                             1569


<210>  589
<211>  2709
<212>  DNA
<213>  Homo sapiens;

<400>  589
atggcggacc cggaggtgtg ctgcttcatc accaaaatcc tgtgcgccca cgggggccgc       60

atggccctgg acgcgctgct ccaggagatc gcgctgtctg agccgcagct ctgtgaggtg      120

ctgcaggtgg ccgggcccga ccgctttgtg gtgttggaga ccggcggcga ggccgggatc      180

acccgatcgg tggtggccac cactcgagcc cgggtctgcc gtcgcaagta ctgccagaga      240

ccctgcgata acctgcatct ctgcaaactc aacttgctgg gccggtgcaa ctattcgcag      300

tccgagcgga atttatgcaa atattctcat gaggttctct cagaagagaa cttcaaagtc      360

ctgaaaaatc acgaactctc tggactgaac aaagaggaat tagcagtgct cctcctccaa      420

agtgatcctt tttttatgcc cgagatatgc aaaagttata agggagaggg tcggcagcag      480

atttgtaacc agcagccacc gtgttcaaga ctccacatct gtgaccactt cacccgaggg      540

aactgtcgtt ttcccaactg cctccggtcc cataacctga tggacagaaa ggtgctggcc      600

atcatgaggg agcacgggct gaaccccgac gtggtccaga acatccagga catctgcaac      660

agcaagcaca tgcagaagaa tcccccaggg cccagagctc cttcttcaca tcgtagaaac      720

atggcatata gggctagaag caagagtaga gatcggttct ttcagggcag ccaagaattt      780

cttgcgtctg cttcagcgtc tgctgagagg tcctgcacac ctagtccaga tcagatcagc      840

cacagggctt ccctggagga cgcgcctgtg gacgatctca cccgcaagtt cacgtatctg      900

gggagtcagg atcgcgctcg gcctccctca ggctcgtcca aggctactga tcttggagga      960

acaagtcagg ccgggacaag ccagaggttt ttagagaacg gcagtcaaga ggacctcttg     1020

catggaaatc caggcagcac ttaccttgct tccaattcaa catcagcccc caactggaag     1080

agcctcacat cctggacgaa tgaccaaggc gccaggagaa agactgtgtt ttctcccacg     1140

ctacctgccg cccgctcttc tcttggctct ctgcaaacac ctgaagctgt gaccaccaga     1200

aagggcacag gcttgctttc ctcagactac aggatcatca atggcaaaag tggaactcag     1260

gacatccagc ctggccctct ttttaataat aatgctgatg gagtggccac agatataact     1320

tctaccagat ccttaaatta caaaagcact agcagcggtc acagagaaat atcatcacct     1380

aggattcagg atgctggacc tgcttcccga gatgtccagg ccactggcag aatcgcagat     1440

gatgctgacc caagagtagc acttgttaac gattctttat ctgatgtcac aagtaccaca     1500

tcttctaggg tggatgatca tgactcagag gaaatttgtc ttgaccatct gtgtaagggt     1560

tgtccgctta atggtagctg cagcaaagtc cacttccatc tgccttaccg gtggcagatg     1620

cttattggta aaacctggac ggactttgag cacatggaga cgatcgagaa aggctactgt     1680

aaccccggaa tccacctctg ttctgtagga agttatacaa tcaattttcg ggtaatgagt     1740

tgtgattcct ttcccatccg acgcctctcc actccttctt ctgtcaccaa gccagccaat     1800

tctgtcttca ccaccaaatg gatttggtat tggaagaatg aatctggcac atggattcag     1860

tatggagaag agaaagacaa acggaaaaat tcaaacgtcg actcttcata cctggagtct     1920

ctctatcaat cctgtccgag gggagttgtg ccatttcagg cgggctcacg gaactatgag     1980

ctgagtttcc aagggatgat tcagacaaac atagcttcca aaactcaaaa ggatgtcatc     2040

agaagaccaa catttgtgcc tcagtggtat gtgcagcaga tgaagagagg gccagaccat     2100

cagccagcaa agacctcgtc agtgtcttta actgcgacct ttcgtcctca ggaggacttt     2160

tgcttcctat cctcaaagaa atataagttg tcagagatcc atcacctaca tccagaatat     2220

gtcagagtaa gtgagcattt taaagcttcc atgaaaaatt tcaagattga aaagataaag     2280

aagatcgaga actcagagct cctggataaa tttacatgga agaaatcgca gatgaaggaa     2340

gaaggaaaac tcctatttta tgcgacaagc cgtgcctatg tggaatctat ctgttcgaat     2400

aattttgaca gtttcctaca tgaaactcat gaaaacaaat acggaaaagg aatttacttt     2460

gcaaaagatg ccatctattc ccacaaaaat tgcccgtatg atgccaaaaa cgtcgttatg     2520

tttgtagccc aagttctggt tggaaagttt actgaaggaa atataacgta cacgagccct     2580

cctccacagt tcgacagctg tgtggatacc agatcgaatc cctccgtttt tgtcatcttt     2640

cagaaagatc aggtttaccc acaatatgtg attgaatata ctgaagacaa agcctgcgtg     2700

attagttag                                                             2709


<210>  590
<211>  1899
<212>  DNA
<213>  Homo sapiens;

<400>  590
atgcagcggg aggagggatt taacaccaag atggcggacg gcccggatga gtacgatacc       60

gaagcgggct gtgtgcccct tctccaccca gaggaaatca aaccccaaag ccattataac      120

catggatatg gtgaacctct tggacggaaa actcatattg atgattacag cacatgggac      180

atagtcaagg ctacacaata tggaatatat gaacgctgtc gagaattggt ggaagcaggt      240

tatgatgtac ggcaaccgga caaagaaaat gttaccctcc tccattgggc tgccatcaat      300

aacagaatag atttagtcaa atactatatt tcgaaaggtg ctattgtgga tcaacttgga      360

ggggacctga attcaactcc attgcactgg gccacaagac aaggccatct atccatggtt      420

gtgcaactaa tgaaatatgg tgcagatcct tcattaattg atggagaagg atgtagctgt      480

attcatctgg ctgctcagtt cggacatacc tcaattgttg cttatctcat agcaaaagga      540

caggatgtag atatgatgga tcagaatgga atgacgcctt taatgtgggc agcatataga      600

acacatagtg tggatccaac tagattgctt ttaacattca atgtttcagt taaccttggt      660

gacaagtatc acaaaaacac tgctctgcat tgggcagtgc tagcagggaa taccacagtc      720

attagccttc ttctggaagc tggagctaat gttgatgccc agaatatcaa gggcgaatca      780

gcgcttgatt tggcaaaaca gagaaaaaat gtgtggatga tcaaccactt acaagaggca      840

aggcaagcaa aaggatatga caatccgtcc ttccttagaa agctgaaagc tgataaggaa      900

tttcggcaga aagtaatgtt aggaactcct ttcctagtta tttggctggt tgggtttata      960

gcagacctaa atattgattc ttggctcatt aaagggctaa tgtatggtgg tgtttgggct     1020

acagtacagt ttctttcaaa atcctttttc gatcattcaa tgcatagtgc attgcccctt     1080

gggatatatt tggcaaccaa attctggatg tatgtgacgt ggttcttctg gttttggaat     1140

gatctcaact ttttatttat ccatcttcca ttccttgcca atagtgttgc acttttctac     1200

aattttggaa aatcttggaa atcagatcca gggattatta aagcaacaga agagcaaaag     1260

aaaaagacaa tagttgaact tgcagagaca ggaagtctgg acctcagtat attctgcagt     1320

acctgtttga tacgaaaacc ggtgaggtcc aaacattgtg gtgtgtgcaa ccgctgtata     1380

gcaaaatttg atcatcattg cccatgggtg ggtaactgtg taggtgcagg caaccataga     1440

tattttatgg gctacctatt cttcttgctt tttatgatct gctggatgat ttatggttgt     1500

atatcttact ggggactcca ctgtgagacc acttacacca aggatggatt ttggacatac     1560

attactcaga ttgccacgtg ttcaccttgg atgttttgga tgttcctgaa cagtgttttc     1620

cacttcatgt gggtggctgt attactcatg tgtcagatgt accagatatc atgtttaggt     1680

attactacaa atgaaagaat gaatgccagg agatacaagc actttaaagt cacaacaacg     1740

tctattgaaa gcccattcaa ccatggatgt gtaagaaata ttatagactt ctttgaattt     1800

cgatgctgtg gcctctttcg tcctgttatc gtggactgga ccaggcagta tacaatagaa     1860

tatgaccaaa tatcaggatc tgggtaccag ctggtgtag                            1899


<210>  591
<211>  1167
<212>  DNA
<213>  Homo sapiens;

<400>  591
atgaaggact gcgagtacca gcagatcagc cccggggccg ccccgctgcc cgcctccccg       60

ggggcgcgcc gtcccggccc cgccgcgtcc ccgactccgg gccccgggcc cgcgccgccc      120

gccgcccccg ccccgccgcg ctggagcagc agcggcagcg gcagcggcag cgggagcggg      180

agcctcggcc gccgcccacg gcgcaagtgg gaggtgttcc cgggtcgcaa tcgcttctac      240

tgcggcggcc gcctcatgct ggccggccac ggcggcgtct tcgcgctcac gctgctgctc      300

atcctcacca ccaccggcct cttcttcgtc tttgactgtc cctacctggc tcgcaagctg      360

acccttgcca tccccatcat cgctgccatc ctcttcttct tcgtcatgag ctgcctgctg      420

cagacaagct tcaccgaccc tgggatcctg ccccgggcca ctgtctgtga agcagccgcc      480

ctggagaaac agatcgacaa cacaggcagt tctacatacc ggccaccccc tcggacccgg      540

gaggtgctga tcaacgggca gatggtgaag ctgaagtact gcttcacctg caagatgttc      600

cggccacccc gaacctcaca ctgcagtgtc tgcgacaact gtgtggaacg atttgaccat      660

cactgcccct gggtgggcaa ctgtgtgggg agacggaact atcgcttctt ctacgcgttt      720

attctctccc tctcattcct gacggccttc atcttcgcct gtgtggtcac ccacctgacg      780

ttgcgcgctc agggaagcaa cttcctctcc actctgaagg agacaccagc aagcgtgctg      840

gagttggtga tctgcttctt ctccatctgg tccattctgg gcctctcagg gtttcacacg      900

tacctcgtcg cctccaacct gactactaat gaagacatca aaggctcgtg gtccagcaag      960

aggggcggtg aggcctctgt caacccctac agccataaaa gtattatcac caactgctgt     1020

gctgtgctct gtggccccct acctcccagc ctaattgacc ggaggggatt tgtgcagtcc     1080

gacaccgtgt tgccctcacc catcagaagc gatgagccag cctgcagagc caagcctgat     1140

gccagcatgg taggaggcca cccctga                                         1167


<210>  592
<211>  642
<212>  DNA
<213>  Homo sapiens;

<400>  592
atggctcagg agactaacca gaccccgggg cccatgctgt gtagcacagg atgtggcttt       60

tatggaaatc ctaggacaaa tggaatgtgt tcagtttgct acaaagaaca tcttcagagg      120

cagcaaaata gtggcagaat gagcccaatg ggaacagcta gtggttccaa cagtcctacc      180

tcagattctg catctgtaca gagagcagac actagcttaa acaactgtga aggtgctgct      240

ggcagcacat ctgaaaaatc aagaaatgtg cctgtggctg ccttgcctgt aactcagcaa      300

atgacagaaa tgagcatttc aagagaggac aaaataacta ccccgaaaac agaggtgtca      360

gagccagttg tcactcagcc cagtccatca gtttctcagc ccagtacttc tcagagtgaa      420

gaaaaagctc ctgaattgcc caaaccaaag aaaaacagat gtttcatgtg cagaaagaaa      480

gttggtctta cagggtttga ctgccgatgt ggaaatttgt tttgtggact tcaccgttac      540

tctgacaagc acaactgtcc gtatgattac aaagcagaag ctgcagcaaa aatcagaaaa      600

gagaatccag ttgttgtggc tgaaaaaatt cagagaatat aa                         642


<210>  593
<211>  5970
<212>  DNA
<213>  Homo sapiens;

<400>  593
atggcgaccg cagatactcc ggccccggcc tccagtggcc tctcgccgaa ggaagaaggg       60

gagcttgaag atggggaaat cagtgacgac gataataaca gccagatacg gagtcggagc      120

agcagcagca gcagcggcgg cgggctgtta ccctatccgc ggcgaaggcc tcctcactcg      180

gcccggggcg gtggatctgg cggaggcggt ggctcttcct cgtcatcgtc ctcttctcag      240

cagcagctga ggaatttctc acgctcgcgg cacgcgtctg agcggggcca cctcagggga      300

cccagcagct accgacccaa agaaccgttc cggtctcatc cgccttctgt acggatgcct      360

tcgagctcac tgtccgaaag cagtccccgg ccgtctttct gggagcggag ccacctcgcc      420

ttggaccgtt tccgctttcg aggcaggcct taccggggtg ggagtcgctg gagtcggggg      480

cgaggagtgg gtgagcgagg aggcaagccg gggtgcagac ctcctctggg aggaggagca      540

ggatccgggt tcagcagcag tcagagctgg cgagagccct ctccacctcg gaagagctcc      600

aaaagttttg gaaggtctcc atcaagaaaa caaaattatt catcaaaaaa tgaaaactgt      660

gtggaagaaa cttttgaaga tttgctttta aagtataaac aaatacagtt ggaactagaa      720

tgcatcaata aggatgaaaa actagcattg agtagcaaag aagagaatgt gcaggaagat      780

cctaaaacat tgaacttcga ggaccaaact agcactgata atgtcagtat tacaaaggat      840

tcaagtaaag aagtagctcc tgaggagaaa acacaagtca aaacttttca ggcatttgaa      900

ttaaaaccac tcaggcaaaa attgacttta ccaggagata agaaccgttt gaaaaaagtt      960

aaagatggag caaaaccact ttccctgaaa tccgacacta ctgattctag tcaaggatta     1020

caagataaag aacaaaattt aacaagaaga attagtacct cagatattct gtctgaaaag     1080

aaacttggtg aagatgaaga ggaactatct gaattacagc ttcgcctttt ggctcttcag     1140

tcagccagta aaaaatggca acaaaaagaa cagcaggtga tgaaagaaag caaagaaaag     1200

ttgactaaga cgaaaactgt acagcaaaaa gttaaaacaa gtacaaaaac acattcggcc     1260

aaaaaagtta gcactacagc taaacaagca ttgaggaagc agcaaacaaa ggcatggaag     1320

aaactacaac aacaaaaaga gcaggaaaga cagaaagaag aggatcagcg gaaacaagct     1380

gaagaagaag agagaaggaa aagagaggaa gaaatcagaa aaattcgaga tctctcaaat     1440

caggaagaac agtacaatcg attcatgaaa ttggttggtg gcaagaggag atcaagaagt     1500

aaatcttcag atcctgacct gaggcgatcc ttagataagc aacctactga tagtggagga     1560

ggcatttatc agtatgataa ctatgaagaa gttgctatgg atacagatag tgaaaccagt     1620

tctccagctc cttcaccagt gcaaccgcca tttttctctg aatgttcatt ggggtatttt     1680

tctccagcac catctctttc tttgcctcca ccacctcagg tttcttctct gccacctttg     1740

agccagcctt atgtggaagg cttgtgtgtt tctcttgaac ctctacctcc tctaccacca     1800

ttaccacctc tcccacctga agatccagaa cagcctccaa aaccaccttt tgcagatgag     1860

gaagaggagg aagaaatgct gcttcgagaa gaactactta aatctctagc aaataaaaga     1920

gcttttaagc cagaggaaac atccagtaat agtgacccac cttcacctcc agttctgaac     1980

aattcacatc ctgtgccaag aagcaatcta tcaatagtca gtattaacac agtgtctcag     2040

cctaggatac agaatccaaa gtttcacaga ggaccccgtc ttccacgaac tgtgatctcg     2100

cttccaaagc ataaatcagt ggttgtaaca ctaaatgatt cagatgatag tgaatctgat     2160

ggagaggctt ccaagtcaac aaatagtgtt tttggtggat tagagtccat gattaaagaa     2220

gcaagacgaa ctgctgagca agcttcaaaa ccgaaagtac ctccaaaatc tgaaaaagaa     2280

aatgatcctc tgcgaacacc ggaggctttg cctgaagaaa agaagattga atatagattg     2340

ttaaaggaag agattgccaa ccgtgagaaa cagcgtttga ttaaatcaga tcagctgaag     2400

acaagttcat catccccagc aaactctgat gtggaaattg atggtattgg caggatagca     2460

atggttacta agcaggttac agatgcagaa tcaaaactga aaaaacatag gattctcttg     2520

atgaaagatg aatctgtttt aaagaattta gtgcaacaag aagctaagaa gaaagaatct     2580

gttagaaatg ctgaagcaaa gattacaaaa cttacagaac agcttcaagc aactgaaaaa     2640

attcttaatg ttaacagaat gtttttgaag aagcttcagg aacaaattca cagagttcaa     2700

cagcgtgtta caattaagaa agctttgact ctaaaatatg gagaagagct tgctcgggca     2760

aaggcagtgg ccagtaaaga aataggaaaa cgtaaactgg aacaagatcg ctttgggcca     2820

aacaaaatga tgagactgga cagttctcca gtatcaagtc caagaaagca ttcagcagaa     2880

ctaattgcta tggagaaaag acggttacaa aagctagaat atgaatatgc cctgaaaatt     2940

caaaaattaa aagaagcccg tgcccttaaa gcaaaggaac aacaaaatat ctctccagtt     3000

gtggaagagg aacccgaatt ttctttacct caaccctcac ttcatgatct gacacaagat     3060

aaattaaccc tggacactga agaaaatgat gttgatgatg aaattttgtc tggttcaagc     3120

agagagcgaa gaagatcttt tttagaatcc aattatttta ctaaacctaa ccttaagcac     3180

actgatactg ctaacaaaga atgcataaac aaacttaata aaaatactgt agaaaaacca     3240

gaactttttc tagggttaaa aattggtgaa ttgcaaaaat tgtattcaaa agctgacagc     3300

ctaaaacagc tgattttaaa aaccaccaca ggcattacag agaaggtttt gcatggtcag     3360

gagatttctg tagatgtgga ttttgtcaca gcacaaagta aaacaatgga agtgaagcca     3420

tgtcctttta gaccctacca tagtcctctt ctagttttta agtcctacag atttagtcca     3480

tattatcgaa ccaaggaaaa acttcccctg agctcagtat catacagtaa tatgattgaa     3540

ccggatcagt gtttctgccg ttttgattta acaggaacat gtaatgatga tgattgtcaa     3600

tggcagcata tacaagacta tacacttagc cgaaaacagt tattccagga cattctgtca     3660

tataatctgt ctttgattgg ttgtgcagag acaagtacta atgaagaaat tactgcttca     3720

gcagaaaaat atgttgagaa actttttgga gtaaacaaag atcgaatgtc aatggaccag     3780

atggctgttc tccttgttag caatatcaat gaaagtaaag gtcatactcc tccatttaca     3840

acctacaaag ataaaagaaa gtggaagcca aagttttgga gaaaacctat ttcagataat     3900

agcttcagta gtgatgagga acagtctaca ggaccaatta agtatgcttt ccagccagag     3960

aaccaaataa atgttccagc tctggataca gttgtcactc cagatgatgt cagatacttt     4020

acaaatgaga ctgatgacat cgctaattta gaagcaagtg tgcttgaaaa tccttctcat     4080

gtacaacttt ggctcaagct tgcgtacaag tacttgaatc aaaatgaggg ggagtgctca     4140

gaatccttgg attctgcttt aaatgttctg gcgcgagcat tggaaaataa caaagacaat     4200

ccagaaattt ggtgccatta cctcagattg ttctcaaaaa gaggaaccaa ggacgaggtg     4260

caggaaatgt gtgaaacagc tgttgaatat gctccagatt atcaaagctt ttggactttt     4320

ctacacctag aaagtacctt tgaagaaaag gattacgtat gtgagagaat gttggagttt     4380

ctgatgggag cagccaagca ggaaacatcc aatattttgt cctttcagct tttagaggct     4440

cttttgttta gagttcagct gcacatattt actggaagat gccaaagtgc actggcaatt     4500

ttacagaatg cattgaaatc tgctaatgat ggaatagtag ctgaatacct taaaaccagt     4560

gatcgatgtt tggcatggtt ggcctacata catcttattg aattcaacat tctcccttca     4620

aaattttatg atccatctaa tgataatcct tcaagaattg ttaacactga atcatttgta     4680

atgccatggc aagctgttca agatgtaaag actaatcctg acatgttgtt agcagttttt     4740

gaagatgcag tgaaagcttg cacagatgag agccttgctg ttgaggaaag aatagaggcc     4800

tgccttccac tttacacaaa catgattgct ctgcaccaac tcctggagag gtatgaggct     4860

gcaatggagc tttgtaaatc tttattggaa tcatgtccta ttaactgcca gttgctggaa     4920

gctcttgttg cattatattt gcaaacaaat cagcatgaca aagccagagc agtgtggctt     4980

actgcatttg aaaaaaatcc tcagaatgca gaggtttttt atcatatgtg caaattcttc     5040

atcttacaga atcgaggcga taatcttctt ccatttttgc ggaaatttat tgcatccttc     5100

tttaaaccgg ggtttgagaa gtataataac ttggatctgt ttcggtatct cttaaatatt     5160

ccaggaccaa ttgacattcc atctcgttta tgtaaaggga attttgatga tgatatgttt     5220

aaccaccaag ttccttattt gtggctgatt tactgccttt gtcatcctct tcaatcaagt     5280

attaaagaaa cagtggaggc atatgaggca gcattagggg tggctatgag atgtgatata     5340

gtacagaaga tatggatgga ttatcttgtc tttgcaaata atagagctgc tggatccaga     5400

aacaaagttc aagaattcaa attttttact gatttagtga atagatgttt ggttacagtc     5460

cctgcccgat accccattcc ttttagcagt gctgattact ggtccaacta tgaatttcat     5520

aatagggtta ttttctttta tttgagctgt gttccaaaga cccagcattc caaaaccttg     5580

gaacggtttt gttcagttat gccagctaat tctggacttg cattgaggtt acttcaacat     5640

gaatgggaag aaagcaatgt tcagattctg aaacttcaag ccaagatgtt tacatataat     5700

atcccaacat gcctggccac ctggaaaata gccattgctg ctgagattgt tctaaaggga     5760

caaagagagg tccaccgttt atatcagaga gccttacaga agttacctct ttgtgcatca     5820

ctgtggaaag atcaactctt gtttgaagca tcagaaggag gtaaaactga taacctgaga     5880

aaactagttt ccaagtgcca agagattgga gtcagcctaa atgagctctt aaatttaaac     5940

agtaacaaaa cagaaagcaa gaatcactga                                      5970


<210>  594
<211>  4620
<212>  DNA
<213>  Homo sapiens;

<400>  594
atggacagtt attttaaagc agctgtcagt gacttggaca aactccttga tgattttgaa       60

cagaacccag atgaacaaga ttatctccaa gatgtacaaa atgcatatga ttctaaccac      120

tgctcagttt cttcagagtt ggcttcctca cagcgaactt cattgctccc aaaagaccaa      180

gagtgcgtta atagttgtgc ctcatcagaa acaagctatg gaacaaatga gagttccctg      240

aatgaaaaaa cactcaaggg acttacttct atacaaaatg aaaaaaatgt aacaggactt      300

gatcttcttt cttctgtgga tggtggtact tcagatgaaa tccagccgtt atatatggga      360

cgatgtagta aacctatctg tgatctgata agtgacatgg gtaacttagt tcatgcaacc      420

aatagtgaag aagatattaa aaaattattg ccagatgatt ttaagtctaa tgcagattcc      480

ttgattggat tggatttatc ttcagtgtca gatactccct gtgtttcttc aacagaccat      540

gatagtgata ctgtcagaga acaacagaat gatatcagtt ctgaattaca aaatagagaa      600

atcggaggaa tcaaagaatt gggtataaaa gtagatacaa cactttcaga ttcctataat      660

tacagtggaa cagaaaattt aaaagataaa aagatcttta atcagttaga atcaattgtt      720

gattttaaca tgtcatctgc tttgactcga caaagttcca aaatgtttca tgccaaagac      780

aagctacaac acaagagcca gccatgtgga ttactaaaag atgttggctt agtaaaagag      840

gaagtagatg tggcagtcat aactgccgca gaatgtttaa aagaagaggg caagacaagt      900

gctttgacct gcagccttcc gaaaaatgaa gatttatgct taaatgattc aaattcaaga      960

gatgaaaatt tcaaattacc tgacttttcc tttcaggaag ataagactgt tataaaacaa     1020

tctgcacaag aagactcaaa aagtttagac cttaaggata atgatgtaat ccaagattcc     1080

tcttcagctt tacatgtttc cagtaaagat gtgccgtcct cattgtcctg tcttcctgcg     1140

tctgggtcta tgtgtggatc attaattgaa agtaaagcac ggggtgattt tttacctcag     1200

catgaacata aagataatat acaagatgca gtgactatac atgaagaaat acagaacagt     1260

gttgttctag gtggggaacc attcaaagag aatgatcttt tgaaacagga aaaatgtaaa     1320

agcatactcc ttcagtcatt aattgaaggg atggaagaca gaaagataga tcctgaccag     1380

acagtaatca gagctgagtc tttggatggt ggtgacacca gttctacagt tgtagaatct     1440

caagaggggc tttctggcac tcatgtccca gagtcttctg attgttgtga aggttttatt     1500

aatacttttt caagcaatga tatggatggg caagacttag attactttaa tattgatgaa     1560

ggcgcaaaaa gtggcccact aattagtgat gctgaacttg atgcctttct gacagaacag     1620

tatcttcaga ccactaacat aaagtctttt gaagaaaatg taaatgactc taaatcgcaa     1680

atgaatcaga tagatatgaa aggcttagat gatggaaaca tcaataatat atatttcaat     1740

gcagaagcag gagctattgg ggaaagtcat ggtattaata taatttgtga aatagttgat     1800

aaacaaaata caatagaaaa tggcctttct ttaggagaaa aaagcactat tccagttcaa     1860

caagggttac ctaccagtaa gtctgagatt acaaatcaat tatcggtctc tgatattaac     1920

agtcaatctg ttggaggggc cagacctaag caattgttta gccttccatc aagaacaagg     1980

agttcaaagg acctgaataa gccagatgtt ccagatacaa tagaaagtga acccagcaca     2040

gcagataccg ttgttccaat cacttgtgct atagattcta cagctgatcc acaggttagc     2100

ttcaactcta attacattga tatagaaagt aattctgaag gtggatctag tttcgtaact     2160

gcaaatgaag attctgtacc tgaaaacact tgcaaagaag gcttggtttt gggccagaaa     2220

cagcctactt gggttcctga ttcagaagct ccaaactgta tgaactgcca agtcaaattt     2280

acttttacca aacggcgaca ccattgccga gcatgtggga aagtattttg tggtgtctgt     2340

tgtaatagga agtgtaaact gcaatatcta gaaaaggaag caagagtatg tgtagtctgc     2400

tatgaaacta ttagtaaagc tcaggcattt gaaaggatga tgagtccaac tggttctaat     2460

cttaagtcta atcattctga tgaatgtact actgtccagc ctcctcagga gaaccaaaca     2520

tccagtatac cttcaccagc aactttgcca gtctcagcac ttaaacaacc aggtgttgaa     2580

ggactatgtt ccaaagaaca gaagagagta tggtttgcag atggtatatt gcccaatggt     2640

gaagttgcag atacaacaaa attatcatct ggaagtaaaa gatgttctga agactttagt     2700

cctctctcac ctgatgtgcc tatgacagta aacacagtgg atcattccca ttctactaca     2760

gtggaaaagc caaacaatga gacaggagat attacaagaa atgagataat tcagagtcct     2820

atttctcagg ttccatcagt ggaaaaattg tctatgaaca caggaaatga ggggttacct     2880

acttctggtt catttacact agatgatgat gtttttgcag aaactgaaga accatctagt     2940

cctactggtg tcttagttaa cagcaattta cctattgcta gtatttcaga ttataggtta     3000

ctgtgtgata ttaacaagta tgtctgcaat aagattagtc ttctacctaa tgatgaggac     3060

agtttgcccc cacttctggt tgcatctgga gaaaagggat cagtgcctgt agtagaagaa     3120

catccatctc atgagcagat cattttgctt cttgaaggtg aaagctttca tcctgttaca     3180

tttgtcctaa atgctaatct actcgtgaat gtcaaattca tattttattc ctcagacaaa     3240

tattggtact tttcaaccaa tggattgcat ggcttgggac aggcagaaat tattattcta     3300

ttgttatgtt tgccaaatga agatactatt cctaaggaca tcttcagact atttatcacc     3360

atatataagg atgctctaaa aggaaaatac atagaaaact tggacaatat tacctttact     3420

gagagttttc tcagtagcaa ggatcacgga ggattcctgt ttattacacc tacttttcag     3480

aaacttgatg atctctcatt accaagtaat ccttttcttt gtggaattct tatccagaag     3540

cttgagattc cctgggcaaa ggtttttcct atgcgtttaa tgttgagatt gggtgcagaa     3600

tataaagcat atcctgctcc tctaacaagc atcagaggcc gaaaacctct ttttggagaa     3660

ataggacaca ctattatgaa cttacttgtt gaccttcgaa attaccagta taccttgcat     3720

aatatagatc aactgttgat tcatatggaa atgggaaaaa gctgcataaa aataccacgg     3780

aaaaagtaca gtgatgtaat gaaagtacta aattcttcca atgagcatgt cattagcatt     3840

ggagcaagtt tcagtacaga agcagattct catctagtct gtatacagaa tgatggaatt     3900

tatgaaacac aggccaacag tgccactggc catcctagaa aagtgacagg tgcaagtttt     3960

gtggtattca atggagctct aaaaacatct tcaggatttc ttgctaagtc cagcatagtt     4020

gaagatggct taatggtaca aataactcca gagaccatga atggcttgcg gctagcttta     4080

cgagaacaga aagactttaa aattacatgt gggaaagttg atgcagtaga cctgagagaa     4140

tacgtggata tctgctgggt agatgctgaa gaaaaaggaa acaaaggagt tatcagttca     4200

gtggatggaa tatcattaca aggatttcca agtgaaaaaa taaaactgga agcagatttt     4260

gaaaccgatg agaagattgt aaaatgtacc gaggtgttct actttctaaa ggaccaggat     4320

ttatctattt tatcaacttc ttatcagttt gcaaaagaaa tagccatggc ttgtagtgct     4380

gcgctgtgcc ctcacctgaa aactctaaaa agtaatggga tgaataaaat tggactcaga     4440

gtttccattg acactgatat ggttgaattt caggcaggat ctgaaggcca acttctgcct     4500

cagcattatc taaatgatct tgatagtgct ctgatacctg tgatccatgg tgggacctcc     4560

aactctagtt taccattaga aatagaatta gtgtttttca ttatagaaca tcttttttag     4620


<210>  595
<211>  3204
<212>  DNA
<213>  Homo sapiens;

<400>  595
atgaattcta tggacaggca catccagcag accaatgacc gactgcagtg catcaagcag       60

cacttacaga atcctgccaa cttccacaat gccgccacgg agctgctgga ctggtgcgga      120

gacccacggg ccttccagcg gcccttcgag cagagcctga tgggctgttt gacggtggtc      180

agtcgggtgg cagcccagca aggctttgac ctggacctcg gctacagact gctggctgtg      240

tgtgctgcaa accgagacaa gttcaccccg aagtctgccg ccttgttgtc ctcctggtgc      300

gaagagctcg gccgcctgct gctgctccga catcagaaga gccgccagag cgatccccct      360

gggaaactcc ccatgcagcc ccctctcagc tccatgagct ccatgaaacc cactctgtcg      420

cacagtgatg ggtcgttccc ctatgactct gtcccttggc agcagaacac caaccagcct      480

cccggctccc tttccgtggt caccacggtt tggggagtaa ccaacacatc ccagagccag      540

gtccttggga accctatggc caatgccaac aaccccatga atccaggcgg caaccccatg      600

gcgtcgggca tgaccaccag caacccaggc ctcaactccc cacagtttgc ggggcagcag      660

cagcagttct cagccaaggc tggccccgct cagccctaca tccagcagag catgtatggc      720

cggcccaact accccggcag cgggggcttt ggggccagtt accctggggg tcctaacgcc      780

cccgcaggca tgggcatccc tccgcacacc aggccgcctg ctgacttcac tcagcccgcg      840

gcagccgctg cagcagcggc agtggcagca gcagcagcca cagctacagc cacagccacg      900

gccactgtgg cagccctgca ggagacacag aacaaggata taaaccagta tggaccgatg      960

ggtcccaccc aggcgtataa cagccaattc atgaaccagc ccgggccgcg ggggcctgcc     1020

tccatggggg gcagcatgaa ccccgcgagc atggcggctg gcatgacgcc ctcggggatg     1080

agcggccctc ccatgggcat gaaccagccc cggccgcccg gcatcagccc ctttggcaca     1140

cacgggcagc ggatgcccca gcagacctac ccgggccccc ggccccagtc ccttcctatt     1200

cagaacataa agaggccata ccctggagag cccaactatg gaaaccagca atatggacca     1260

aacagccagt tccccaccca gccaggccag tacccagccc ccaacccccc gaggccactc     1320

acctccccca actacccagg acagaggatg cccagccagc cgagctccgg gcagtacccg     1380

ccccccacgg tcaacatggg gcagtattac aagccagaac agtttaatgg acaaaataac     1440

acgttctcgg gaagcagcta cagtaactac agccaaggga atgtcaacag gcctcccagg     1500

ccggttcctg tggcaaatta cccccactca cctgttccag ggaaccccac accccccatg     1560

acccctggga gcagcatccc tccatacctg tcccccagcc aagacgtcaa accacccttc     1620

ccgcctgaca tcaagccaaa tatgagcgct ctgccaccac ccccagccaa ccacaatgac     1680

gagctgcggc tcacattccc tgtgcgggat ggcgtggtgc tggagccctt ccgcctggag     1740

cacaacctgg cggtcagcaa ccatgtgttc cacctgcggc ccacggtcca ccagacgctg     1800

atgtggaggt ctgacctgga gctgcagttc aagtgctacc accacgagga ccggcagatg     1860

aacaccaact ggcccgcctc ggtgcaggtc agcgtgaacg ccacgcccct caccattgag     1920

cgcggcgaca acaagacctc ccacaagccc ctgcacctga agcacgtgtg ccagccgggc     1980

cgcaacacca tccagatcac cgtcacggcc tgctgctgct cccacctctt cgtgctgcag     2040

ctggtacacc ggccctccgt ccgctctgtg ctgcaaggac tcctcaagaa gcgcctcctg     2100

cccgcagagc actgtatcac gaaaatcaag cggaatttca gcagcgtggc tgcctcctcg     2160

ggcaacacga ccctcaacgg ggaggatggg gtggagcaga cggccatcaa ggtgtctctg     2220

aagtgcccca tcacattccg gcgcatccag ctgcctgctc gaggacacga ttgcaagcat     2280

gtgcagtgct ttgatctgga gtcatacctg cagctgaatt gcgagagagg gacctggagg     2340

tgtcctgtgt gcaataaaac cgctctgctg gagggcctgg aggtggatca gtacatgtgg     2400

ggaatcctga atgccatcca acactccgag tttgaagagg tcaccatcga tcccacgtgc     2460

agctggcggc cggtgcccat caagtcggac ttacacatca aggacgaccc tgatggcatc     2520

ccctccaagc ggttcaagac catgagtccc agccagatga tcatgcccaa tgtcatggag     2580

atgatcgcag ccctgggccc cggcccgtcc ccctatcccc tcccgcctcc cccagggggc     2640

accaactcca acgactacag cagccaaggc aacaactacc aaggccatgg caactttgac     2700

ttcccccacg ggaaccctgg agggacatcc atgaatgact tcatgcacgg gcccccccag     2760

ctctcccacc ccccggacat gcccaacaac atggccgccc tcgagaaacc cctcagccac     2820

cccatgcagg aaactatgcc acacgctggc agctctgacc agccccaccc ctccatacaa     2880

caaggtttgc acgtaccaca ccccagcagc cagtcagggc ctccattaca tcacagtggg     2940

gctcctcctc ctcctccttc ccagcctccc cggcagccgc cacaggccgc tcccagcagc     3000

catccacaca gcgacctgac ctttaacccc tcctcagcct tagagggtca ggccggagcg     3060

cagggagcgt ccgacatgcc ggagccttcg ctggatctcc ttcccgaact cacaaatcct     3120

gacgagctcc tgtcttatct ggaccccccc gacctgccga gcaatagtaa cgatgacctc     3180

ctgtctctat ttgagaacaa ctga                                            3204


<210>  596
<211>  1917
<212>  DNA
<213>  Homo sapiens;

<400>  596
atgttgttag cccaaataaa tcgagattct cagggaatga cagagtttcc tggaggaggg       60

atggaggcgc aacatgttac gctgtgcttg acagaggcag tcaccgtggc agatggtgac      120

aacttagaaa atatggaagg cgtaagcttg caagcagtaa cacttgcaga tggttctact      180

gcttacatac aacacaattc taaagatgca aaactcatag atggccaggt cattcagttg      240

gaagatggtt ctgcggccta tgttcaacat gtacccatac ctaaaagtac aggggacagt      300

ttgcgtctag aggatggtca agcagtacag ttagaagatg gtaccacagc atttattcac      360

cacacctcca aagatagtta tgaccagagt gcattacagg cggttcagct ggaagatggt      420

accacagctt atatccacca tgcagtgcaa gtcccgcagt ctgacaccat cttggcaatt      480

caggctgatg ggacagtggc aggtctgcac actggggatg ctacaattga ccctgacacc      540

atcagtgctt tggaacagta tgcagcaaag gtgtccattg atggaagtga aagtgtagca      600

ggtactggaa tgattggaga aaatgagcaa gagaaaaaaa tgcagattgt tttacaagga      660

catgctacaa gagtaactgc taaatctcaa cagagtggag agaaggcatt tcgatgtgaa      720

tatgatggat gtggaaaatt atatacaaca gctcatcatc tcaaggtcca tgagaggtca      780

cacacaggag atcggcctta tcagtgtgag catgcaggct gtgggaaggc atttgcaaca      840

ggttatggat taaaaagtca cgtcagaact catacaggag aaaagccata tcggtgttcg      900

gaagataatt gtactaaatc tttcaaaact tcaggagatc tacagaaaca catcagaact      960

catacaggag aaaggccctt taagtgtccc ttcgaaggct gcggtcggtc ctttacaaca     1020

tcaaatatca gaaaagtgca cgttaggaca cacacaggag aaagacctta ttactgcaca     1080

gagccaggat gtgggagggc atttgccagt gcaacaaatt ataaaaacca tgtgaggata     1140

cacacaggag aaaagccata tgtttgtaca gttcctgggt gtgacaaaag gtttacagaa     1200

tattccagtt tgtacaaaca tcatgttgtc cacactcatt ccaaacctta caactgtaac     1260

cactgtggga agacatacaa gcagatctcc acgctggcca tgcacaaacg gacagcccac     1320

aacgacactg agcccatcga ggaggagcag gaagccttct ttgagccgcc cccaggtcaa     1380

ggtgaagatg ttcttaaagg gtcccagatt acgtatgtta caggtgtaga aggggacgac     1440

gttgtttcta cacaagtagc cacagtaacc caatctggac tgagtcaaca agttacactc     1500

atatcccagg atgggactca gcatgtcaac atatctcaag ctgacatgca ggccattggc     1560

aacaccatca caatggtaac gcaggatggc acgcccatca cagtccccgc ccatgatgca     1620

gtcatctcct cagcaggaac gcactctgtt gctatggtta ctgctgaggg tacagaaggg     1680

gaacaggttg caattgtagc tcaagacttg gcagcattcc atactgcctc atcagaaatg     1740

gggcaccagc agcatagcca tcacttagta accacagaaa ccagacctct gaccttagta     1800

gcaacatcca atggcaccca gattgcagtt cagcttggag aacagccatc tctggaagaa     1860

gccatcagaa tagcgtctag aatccaacaa ggagaaacgc cagggttgga tgattaa        1917


<210>  597
<211>  2385
<212>  DNA
<213>  Homo sapiens;

<400>  597
atgaacattg acgacaaact ggaaggattg tttcttaaat gtggcggcat agacgaaatg       60

cagtcttcca ggacaatggt tgtaatgggt ggagtgtctg gccagtctac tgtgtctgga      120

gagctacagg attcagtact tcaagatcga agtatgcctc accaggagat ccttgctgca      180

gatgaagtgt tacaagaaag tgaaatgaga caacaggata tgatatcaca tgatgaactc      240

atggtccatg aggagacagt gaaaaatgat gaagagcaga tggaaacaca tgaaagactt      300

cctcaaggac tacagtatgc acttaatgtc cctataagcg taaagcagga aattactttt      360

actgatgtat ctgagcaact gatgagagac aaaaaacaaa tcagagagcc agtagactta      420

cagaaaaaga agaagcggaa acaacgttct cccgcaaaaa tccttacaat aaatgaggat      480

ggatcacttg gtttgaaaac ccctaaatct cacgtttgtg agcactgcaa tgctgccttt      540

agaacgaact atcacttaca gagacatgtc ttcattcata caggtgaaaa accatttcaa      600

tgtagtcaat gtgacatgcg tttcatacag aagtacctgc ttcagagaca tgagaagatt      660

catactggtg aaaaaccatt tcgctgtgat gaatgtggta tgagattcat acaaaaatat      720

catatggaaa ggcataagag aactcatagt ggagaaaaac cttaccagtg tgaatactgt      780

ttacagtatt tttccagaac agatcgtgta ttgaaacata aacgtatgtg ccatgaaaat      840

catgacaaaa aactaaatag atgtgccatc aaaggtggcc ttctgacatc tgaggaagat      900

tctggctttt ctacatcacc aaaagacaac tcactgccaa aaaagaaaag gcagaaaacg      960

gagaaaaaat catctggaat ggacaaagag agtgctttgg acaaatctga cctgaaaaaa     1020

gacaaaaatg attacttgcc tctttattct tcaagtacta aagtaaaaga tgagtatatg     1080

gttgcagaat atgctgttga aatgccacat tcgtcagttg ggggctcgca tttagaagat     1140

gcgtcaggag aaatacaccc acctaagtta gttctcaaaa aaattaatag taagagaagt     1200

ctgaaacagc cactggagca aaatcaaaca atttcacctt tatccacata tgaagagagc     1260

aaagtttcaa agtatgcttt tgaacttgtg gataaacagg ctttactgga ctcagaaggc     1320

aatgctgaca ttgatcaggt tgataatttg caggaggggc ccagtaaacc tgtgcatagt     1380

agtactaatt atgatgatgc catgcagttt ttgaagaaga agcggtatct tcaagcagca     1440

agtaacaaca gcagggaata tgcgctgaat gtgggtacca tagcttctca gccttctgta     1500

acacaagcag ctgtggcaag tgtcattgat gaaagtacca cggcatccat attagagtca     1560

caggcactga atgtggagat taagagtaat catgacaaaa atgttattcc agatgaggta     1620

ctgcagactc tgttggatca ttattcccac aaagctaatg gacagcatga gatatccttc     1680

agtgttgcag atactgaagt gacttctagc atatcaataa attcttcaga agtaccagag     1740

gtcaccccgt cagagaatgt tggatcaagc tcccaagcat cctcatcaga taaagccaac     1800

atgttgcagg aatactccaa gtttctgcag caggctttgg acagaactag ccaaaatgat     1860

gcctatttga atagcccgag ccttaacttt gtgactgata accagaccct cccaaatcag     1920

ccagcattct cttccataga caagcaggtc tatgccacca tgcccatcaa tagctttcga     1980

tcaggaatga attctccact aagaacaact ccagataagt cccactttgg actaatagtt     2040

ggtgattcac agcactcatt tcccttttca ggtgatgaga caaaccatgc ttctgccaca     2100

tcaacacagg actttctgga tcaagtgact tctcagaaga aagctgaggc ccagcctgtc     2160

caccaagctt accaaatgag ctcctttgaa cagcccttcc gtgctcccta tcatggatca     2220

agagctggaa tagctactca atttagcact gccaatggac aggtgaacct tcggggacca     2280

gggacaagtg ctgaattttc agaatttccc ttggtgaatg taaatgataa tagagctggg     2340

atgacatctt cacctgatgc cacaactggc cagacttttg gctaa                     2385


<210>  598
<211>  1647
<212>  DNA
<213>  Homo sapiens;

<400>  598
atgaacattg aggttgttga ggtcctcaca ctgaaccagg aggtggctgg tccccggaat       60

gcccagatcc aggccctata tgctgaagat ggaagcctga gtgcagatgc ccccagtgag      120

caggtccaac agcagggcaa gcatccaggt gaccctgagg ccgcgcgcca gaggttccgg      180

cagttccgtt ataaggacat gacaggtccc cgggaggccc tggaccagct ccgagagctg      240

tgtcaccagt ggctacagcc taaggcacgc tccaaggagc agatcctgga gctgctggtg      300

ctggagcagt tcctaggtgc actgcctgtg aagctccgga catgggtgga atcgcagcac      360

ccagagaact gccaagaggt ggtggccctg gtagagggtg tgacctggat gtctgaggag      420

gaagtacttc ctgcaggaca acctgccgag ggcaccacct gctgcctcga ggtcactgcc      480

cagcaggagg agaagcagga ggatgcagcc atctgcccag tgacagtgct ccctgaggag      540

ccagtgacct tccaggatgt ggctgtggac ttcagccggg aggagtgggg gctgctgggc      600

ccgacacaga ggaccgagta ccgcgatgtg atgctggaga cctttgggca cctggtctct      660

gtggggtggg agactacact ggaaaataaa gagttagctc caaattctga cattcctgag      720

gaagaaccag cccccagcct gaaagtacaa gaatcctcaa gggattgtgc cttgtcctct      780

acattagaag ataccttgca gggtggggtc caggaagtcc aagacacagt gttgaagcag      840

atggagtctg ctcaggaaaa agaccttcct cagaagaagc actttgacaa ccgtgagtcc      900

caggcaaaca gtggtgctct tgacacaaac caagtttcgc tccagaaaat tgacaaccct      960

gagtcccagg caaacagtgg cgctcttgac acaaaccaag ttttgctcca caaaattcct     1020

cctagaaaac gattgcgcaa acgtgactca caagttaaaa gtatgaaaca taattcacgt     1080

gtaaaaattc atcagaagag ctgtgaaagg caaaaggcca aggaaggcaa tggttgtagg     1140

aaaaccttca gtcggagtac taaacagatt acgtttataa gaattcacaa ggggagccaa     1200

gtttgccgat gcagtgaatg tggtaaaata ttccggaacc caagatactt ttctgtgcat     1260

aagaaaatcc ataccggaga gaggccctat gtgtgtcaag actgtgggaa aggatttgtt     1320

cagagctctt ccctcacaca gcatcagaga gttcattctg gagagagacc atttgaatgt     1380

caggagtgtg ggaggacctt caatgatcgc tcagccatct cccagcacct gaggactcac     1440

actggcgcta agccctacaa gtgtcaggac tgtggaaaag ccttccgcca gagctcccac     1500

ctcatcagac atcagaggac tcacaccggg gagcgcccat atgcatgcaa caaatgtgga     1560

aaggccttca cccagagctc acaccttatt gggcaccaga gaacccacaa taggacaaag     1620

cgaaagaaga aacagcctac ctcatag                                         1647


<210>  599
<211>  8172
<212>  DNA
<213>  Homo sapiens;

<400>  599
atggcggacg aagaggccga gcaggagagg ttgagttgcg gcgaaggcgg ctgcgtcgcg       60

gagctgcagc gcctgggcga gcggctccag gagctggagc tacagctgcg ggagagccgg      120

gtaccggccg tggaagcggc caccgactac tgtcagcagc tgtgccagac actcctagaa      180

tatgcagaga aatggaaaac ttcagaagat cctttacctt tattggaggt atacacagtg      240

gctatccaaa gttatgttaa agcccgacct tatcttacct ctgaatgtga aaatgtagcc      300

ttggttctgg aacgcttggc attaagctgt gttgaacttt tactgtgtct gcctgttgag      360

ttatcagata aacagtggga acaatttcag acactggtgc aggtagctca tgaaaagctg      420

atggagaatg gcagctgtga attgcatttt ttagctactc tagctcaaga gactggggtg      480

tggaaaaacc cggtactgtg cactattctt tcccaggaac cattggataa ggataaagtg      540

aatgaatttt tagcttttga gggtcccatc ttgttggata tgagaattaa acatctaatc      600

aaaacaaatc agttaagtca agcaactgct ctagcaaagc tgtgttctga ccatccagag      660

attggcataa aaggtagttt taagcaaact taccttgtct gtctttgtac atcatcacca      720

aatggaaagt taatcgaaga gatttcagaa gttgattgca aagatgcact ggaaatgatc      780

tgtaacttag aatctgaggg tgatgaaaaa agcgctcttg ttttatgtac tgcgtttttg      840

tcacgtcagc tccaacaagg agatatgtac tgcgcttggg aacttactct cttttggagt      900

aaattacaac aaagagtaga accatctata caagtgtacc ttgagaggtg tcgtcaactt      960

tctttgttaa cgaaaacagt atatcacatt ttcttcctga ttaaagttat taattcagag     1020

actgaagggg ctggacttgc tacctgtata gaactgtgtg taaaggctct tcgcttggag     1080

tctacagaaa atactgaagt gaaaatatct atttgcaaga ccatttcatg tttgttgcct     1140

gatgatctgg aagttaaacg tgcttgtcaa ctgagtgaat ttcttattga gcctacagta     1200

gatgcgtatt atgctgtgga aatgttgtat aatcagccag accagaaata tgatgaagag     1260

aatcttccaa taccaaattc tttacgctgt gagctgttac ttgtattgaa aactcaatgg     1320

ccctttgatc cagaattctg ggattggaaa accttgaaac gacaatgtct tgcattaatg     1380

ggagaagaag catccattgt gtcttcaata gatgaactaa atgacagtga agtatatgaa     1440

aaagtggtag actaccaaga agagagtaaa gaaacttcta tgaatgggct ttctggtgga     1500

gttggtgcta attctggcct tcttaaagac attggtgatg aaaagcagaa gaagagagag     1560

ataaaacagt taagagagag gggatttata tctgctcggt ttaggaattg gcaagcctac     1620

atgcagtatt gtgtgttgtg tgacaaagaa ttccttggtc acagaatagt acgacatgct     1680

cagaaacatt acaaagatgg aatttatagt tgccccatat gtgcaaagaa ctttaattct     1740

aaagaaactt ttgtccctca tgtcacactg catgttaaac aatctagtaa agagagacta     1800

gcagctatga aaccattaag aagattggga aggcctccaa agatcacaac taccaatgaa     1860

aatcagaaga ctaatactgt ggctaaacag gagcagcgac ctataaaaaa gaatagtctc     1920

tattcaacag attttatagt gtttaatgac aatgatggtt cagatgatga gaatgatgac     1980

aaagataaat cctatgagcc agaagtgatt ccagtccaga aaccagtacc tgttaatgaa     2040

tttaattgcc ctgtaacttt ttgtaaaaag ggctttaagt actttaaaaa tttaattgct     2100

catgtgaagg ggcataaaga taatgaagac gccaagcgct ttcttgaaat gcagagcaaa     2160

aaagttattt gccagtactg taggcggcat tttgtgagtg ttactcatct caatgatcac     2220

ttacagatgc actgtggcag taaaccatat atctgtatac agatgaaatg taaagctggt     2280

tttaatagtt acgccgagct tttaacccac cgaaaggagc atcaagtctt tagagcaaaa     2340

tgtatgtttc ctaaatgtgg aagaattttt tcggaagctt atttactata tgatcatgaa     2400

gcacaacatt ataatacgta cacttgtaag ttcacaggtt gtggtaaagt ttatcgttct     2460

cagggtgagc tggaaaagca tctggatgat cacagtactc ctcctgaaaa agtgctgcct     2520

cctgaagccc aacttaattc atctggagat tccattcagc cttctgaagt gaatcagaac     2580

acagcagaga atattgagaa agaaagatct atgcttcctt cagaaaataa cattgaaaac     2640

agcttactag cagatagaag tgatgcttgg gataaaagca aagcagaatc agctgtgacc     2700

aaacaagacc agatttctgc ctctgagctc aggcaagcta atggaccatt gtcaaatggt     2760

ttggaaaacc ctgctactac tcctctactt caatccagtg aagtagctgt gtccattaag     2820

gtgtctctca atcaggggat tgaggataac tttggaaagc aagaaaactc aactgtggaa     2880

ggcagtggtg aagcactggt cacagactta catacgccag ttgaagatac ttgtaatgat     2940

ttgtgtcatc caggtttcca ggagagaaaa gaacaagatt gctttaatga tgcccatgtt     3000

actcagaatt ctttagtaaa ttcagaaact ctcaaaatag gtgaccttac cccacaaaac     3060

ttagaaagac aagtgaacaa cttgatgacc ttttctgtgc aaaatcaggc agcatttcaa     3120

aacaatttac caacttccaa atttgaatgt ggagataatg ttaaaacatc atccaatctt     3180

tataatttac ctcttaagac attagaaagt attgcatttg ttccaccgca gtccgaccta     3240

agtaattcat taggaactcc atcagtgcct ccaaaagctc cagttcagaa attcagctgc     3300

caggtcgagg gatgtactcg aacctataat tcttcacaga gtattgggaa acacatgaag     3360

acagcacacc ctgaccaata tgctgcattt aaaatgcagc gcaaaagtaa aaaaggtcag     3420

aaagctaaca acttaaatac accaaataat ggaaagtttg tttatttttt gccatcaccg     3480

gtgaacagct caaatccatt ttttacatca cagaccaaag ccaatgggaa tcctgcttgt     3540

tcggcccagt tgcagcatgt ctcgccaccc atttttccag ctcatttagc aagtgtgtca     3600

actccattgt tgtcctcaat ggaaagtgtc ataaatccaa atataacttc tcaggataaa     3660

aatgaacaag gtggtatgtt atgttcccaa atggaaaatt tacctagtac tgccttgcca     3720

gcacaaatgg aagatctaac caaaacagtt ctgcctttga atattgacag tggctcagat     3780

cctttccttc ctttacctgc agaaagtagt tcaatgtctc tcttcccttc accagcagat     3840

agtgggacta attctgtttt ttcccaactg gaaaataata caaatcatta ttcctcacag     3900

attgaaggaa acactaattc ctcctttcta aaggggggta atggtgaaaa tgcagttttt     3960

ccttcacaag tgaatgttgc aaataacttc agtagcacca atgcccaaca gtctgcacct     4020

gaaaaagtta aaaaagaccg tgggcggggc ccaaatggga aggaaagaaa acctaagcac     4080

aacaaaaggg ctaaatggcc tgcaattatc agagatggga aatttatctg tagcaggtgt     4140

tacagggctt ttactaatcc cagatcactg ggtgggcact tatccaagcg atcttactgt     4200

aaaccactgg atggagccga aattgctcaa gaacttctac agagtaatgg acagccttct     4260

cttcttgcca gcatgattct ctccacaaat gcagtaaatt tgcagcagcc acaacaatct     4320

accttcaatc cagaagcatg ttttaaagat ccatcatttc tacagcttct tgctgaaaat     4380

cgctcgccag catttttacc aaatacattt cctcgatctg gtgtgactaa ctttaatacc     4440

agtgtcagtc aagaaggtag tgaaattatt aaacaggctt tggaaactgc tggcattccc     4500

agtacatttg agggtgccga aatgctttct catgtttcaa caggttgtgt ctctgatgca     4560

tcacaagtaa atgcaacggt gatgccaaat ccaactgtac cacccctgtt gcacactgta     4620

tgccatccaa acaccttgct gaccaaccag aataggacgt caaactccaa aacttcctcc     4680

attgaggaat gtagcagctt gcctgttttt ccaacgaatg acttactact gaagactgtt     4740

gaaaatggtt tgtgctctag ttcatttcct aattctggtg ggccatcaca aaattttacc     4800

agtaacagtt ctcgtgtttc tgttataagt ggtcctcaga acacaagatc cagtcattta     4860

aataaaaagg gaaacagtgc ttctaagaga agaaagaaag ttgctcctcc actaattgca     4920

cctaacgctt cccaaaactt ggtaacaagt gacttaacaa caatgggact catagcaaag     4980

agtgttgaaa tcccaactac taaccttcat tcaaatgtaa ttccaacttg tgaacctcag     5040

agtttggtgg aaaatctaac acagaaatta aataatgtta acaatcagtt atttatgact     5100

gatgtaaaag agaatttcaa aaccagtctt gagtcccata cagtgttagc ccctttaaca     5160

ttaaaaactg aaaatggtga ttcccaaatg atggctttga attcatgcac aacttcaata     5220

aattctgatt tgcagatttc tgaagacaat gttatacaaa actttgaaaa gactcttgaa     5280

attattaaaa ctgctatgaa ttctcaaata cttgaggtaa aaagtggatc tcagggtgct     5340

ggtgaaactt cacaaaatgc tcaaataaat tataacattc agcttccttc agtaaacact     5400

gtgcaaaata acaaattacc cgattcttct ccgttttcct cctttataag tgtcatgcca     5460

acaaaaagta acattcctca gtctgaagta tcacataagg aggatcaaat acaggaaatt     5520

ttagaaggct tacagaaatt aaaattagaa aatgacctat ccactccagc atcccaatgt     5580

gtactgataa atacatcagt gacactgact cccacgcctg ttaaatcaac tgcagatatc     5640

acagttattc agccagtttc tgaaatgata aacattcaat ttaatgacaa agttaataaa     5700

ccctttgtgt gtcaaaacca aggctgtaac tacagtgcta tgacaaagga tgcactattt     5760

aagcactatg gtaaaattca tcaatacact ccagaaatga ttcttgaaat taagaagaat     5820

caattgaaat ttgctccctt taaatgtgta gtacctacat gtacaaaaac atttacaaga     5880

aattctaacc tccgggcaca ctgtcagttg gtgcatcatt ttacaactga agaaatggta     5940

aagttaaaaa ttaaaaggcc ttatggaaga aaatctcaga gtgaaaatgt gccggcctca     6000

cgaagtacac aagtgaaaaa acagctagct atgacagagg aaaataaaaa ggaatctcag     6060

cctgctttag aattgagagc agagacccaa aatacccaca gtaatgtagc agtgatccca     6120

gaaaaacaac ttgtagaaaa aaaaagtcct gacaaaacag aaagttcttt acaagtgatt     6180

acagttactt cagaacaatg taatacaaat gcactcacaa acacacaaac caaaggacgg     6240

aagattagga ggcataaaaa agaaaaggag gagaaaaaac gaaagaagcc agtttcccaa     6300

tcccttgagt ttccaacaag atacagtcct tacagacctt atcgatgtgt tcaccaggga     6360

tgctttgctg cctttacgat acagcaaaac ttgattctcc attaccaggc tgtacacaaa     6420

tcagatctac ctgcattttc agcagaggtc gaagaggaaa gtgaagctgg taaagaaagt     6480

gaagaaactg aaactaaaca aactttgaaa gaatttcgat gtcaggtaag tgactgttct     6540

cgaattttcc aagcaattac tggcctaata caacactaca tgaaacttca tgaaatgact     6600

cctgaagaaa ttgaaagtat gactgcttca gtggatgttg ggaagtttcc atgtgaccag     6660

ttagagtgta aatcttcatt tactacatat ttgaactatg ttgttcatct agaggcagac     6720

cacgggattg gactaagggc aagtaaaaca gaagaagatg gtgtatacaa atgtgattgt     6780

gaaggctgtg accgtatata tgcaacccgg tcgaatctcc tccgacacat ttttaataag     6840

cataatgaca aacataaggc tcatttgatt cgtccaagaa gattaacacc aggccaggaa     6900

aatatgtcaa gcaaggcaaa ccaagaaaaa tcaaagtcta aacatcgggg gaccaagcac     6960

agcagatgtg gaaaggaagg aataaaaatg cccaagacca aacgaaagaa aaaaaataat     7020

ttagaaaaca agaatgcaaa gattgtgcag attgaagaaa ataagcctta ttctctgaaa     7080

cgtgggaagc atgtatattc tataaaggct agaaatgatg ccctgtctga gtgtacaagc     7140

agatttgtaa cccagtatcc atgtatgata aagggatgta cttcagttgt tacaagtgaa     7200

agcaatataa ttagacatta taagtgccat aaattatcta aggcatttac atcacaacac     7260

cgaaatcttc ttattgtatt caaacggtgt tgcaactcac aagtaaagga aacgtctgag     7320

caagaaggtg ctaagaatga tgtgaaagat tctgacacgt gtgtatcaga gagcaatgat     7380

aattcaagaa caacagctac agtttcacaa aaggaagttg aaaaaaatga aaaagatgaa     7440

atggatgaac taacagaatt gtttattaca aaattaataa atgaagatag cacaagtgta     7500

gagacccaag ctaatacttc ttcaaatgta agtaatgatt ttcaggaaga taacctctgc     7560

cagtcagaaa gacaaaaagc aagtaatttg aagagagtta ataaggaaaa aaatgtctca     7620

caaaataaaa aaaggaaagt tgaaaaagct gaaccagcat cagcagctga gttaagtagc     7680

gtgcgtaaag aagaagaaac tgctgttgcc attcaaacca ttgaggagca tcctgcatct     7740

tttgactgga gctcttttaa gccaatggga tttgaagtat catttctgaa gtttcttgag     7800

gagtctgcag tgaagcagaa gaaaaatact gacaaagacc atccgaatac tggaaacaaa     7860

aaaggatccc attcaaattc aagaaaaaat attgataaga ctgctgtgac tagtggaaat     7920

catgtatgtc cttgtaaaga aagcgaaacg tttgtacagt ttgccaatcc atcacagctt     7980

cagtgcagtg ataatgtaaa aattgtttta gacaagaatc ttaaagattg cactgagctt     8040

gtcttaaagc aacttcagga aatgaaacct accgtcagtc tgaaaaaact tgaagtacat     8100

tcaaatgatc cagatatgtc tgttatgaaa gatatcagta taggtaaagc cacaggcaga     8160

ggtcagtact ga                                                         8172


<210>  600
<211>  2577
<212>  DNA
<213>  Homo sapiens;

<400>  600
atggacctcc cggcgctgct ccccgccccg actgcgcgcg gagggcaaca tggcggcggc       60

cccggcccgc tccgccgagc cccagcgccg ctcggcgcga gccccgcgcg ccgccgcctg      120

ctactggtgc ggggccctga agatggcggg cccggggcgc ggcccgggga ggcctccggg      180

ccaagcccgc cgcccgccga ggacgacagc gacggcgact ctttcttggt gctgctggaa      240

gtgccgcacg gcggcgctgc cgccgaggct gccggatcac aggaggccga gcctggctcc      300

cgtgtcaacc tggcgagccg ccccgagcag ggccccagcg gcccggccgc cccccccggc      360

cctggcgtag ccccggcggg cgccgtcacc atcagcagcc aggacctgct ggtgcgtctc      420

gaccgcggcg tcctcgcgct gtctgcgccg cccggccccg caaccgcggg cgccgccgct      480

ccccgccgcg cgccccaggc ctccggcccc agcacgcccg gctaccgctg ccccgagccg      540

cagtgcgcgc tggccttcgc caagaagcac cagctcaagg tgcacctgct cacgcacggc      600

ggcggtcagg gccggcggcc cttcaagtgc ccactggagg gctgtggttg ggccttcaca      660

acgtcctaca agctcaagcg gcacctgcag tcgcacgaca agctgcggcc cttcggctgt      720

ccagtgggcg gctgtggcaa gaagttcact acggtctata acctcaaggc gcacatgaag      780

ggccacgagc aggagagcct gttcaagtgc gaggtgtgcg ccgagcgctt ccccacgcac      840

gccaagctca gctcccacca gcgcagccac ttcgagcccg agcgccctta caagtgtgac      900

tttcccggct gtgagaagac atttatcaca gtgagtgccc tgttttccca taaccgagcc      960

cacttcaggg aacaagagct cttttcctgc tcctttcctg ggtgcagcaa gcagtatgat     1020

aaagcctgtc ggctgaaaat tcacctgcgg agccatacag gtgaaagacc atttatttgt     1080

gactctgaca gctgtggctg gaccttcacc agcatgtcca aacttctaag gcacagaagg     1140

aaacatgacg atgaccggag gtttacctgc cctgtcgagg gctgtgggaa atcattcacc     1200

agagcagagc atctgaaagg ccacagcata acccacctag gcacaaagcc gttcgagtgt     1260

cctgtggaag gatgttgcgc gaggttctcc gctcgtagca gtctgtacat tcactctaag     1320

aaacacgtgc aggatgtggg tgctccgaaa agccgttgcc cagtttctac ctgcaacaga     1380

ctcttcacct ccaagcacag catgaaggcg cacatggtca gacagcacag ccggcgccaa     1440

gatctcttac ctcagctaga agctccgagt tctcttactc ccagcagtga actcagcagc     1500

ccaggccaaa gtgagctcac taacatggat cttgctgcac tcttctctga cacacctgcc     1560

aatgctagtg gttctgcagg tgggtcggat gaggctctga actccggaat cctgactatt     1620

gacgtcactt ctgtgagctc ctctctggga gggaacctcc ctgctaataa tagctcccta     1680

gggccgatgg aacccctggt cctggtggcc cacagtgata ttcccccaag cctggacagc     1740

cctctggttc tcgggacagc agccacggtt ctgcagcagg gcagcttcag tgtggatgac     1800

gtgcagactg tgagtgcagg agcattaggc tgtctggtgg ctctgcccat gaagaacttg     1860

agtgacgacc cactggcttt gacctccaat agtaacttag cagcacatat caccacaccg     1920

acctcttcga gcaccccccg agaaaatgcc agtgtcccgg aactgctggc tccaatcaag     1980

gtggagccgg actcgccttc tcgcccagga gcagttgggc agcaggaagg aagccatggg     2040

ctgccccagt ccacgttgcc cagtccagca gagcagcacg gtgcccagga cacagagctc     2100

agtgcaggca ctggcaactt ctatttggaa agtgggggct cagcaagaac tgattaccga     2160

gccattcaac tagccaagga aaaaaagcag agaggagcgg ggagcaatgc aggagcctca     2220

cagtctactc agagaaaaat aaaagaaggc aaaatgagtc ctccccattt ccatgcaagc     2280

cagaacagtt ggttgtgtgg gagcctcgtg gtgcccagcg gaggacggcc aggaccagct     2340

ccagcagctg gggtgcagtg cggggcgcag ggcgtccagg tccagctggt gcaggatgac     2400

ccctccggcg aaggtgtcct gccctcggcc cgcggcccag ccaccttcct ccccttcctc     2460

actgtggacc tgcccgtcta cgtcctccag gaggtgctcc cctcatctgg aggccctgct     2520

ggaccggagg ccacccagtt cccaggaagc actatcaacc tgcaggatct gcagtga        2577


<210>  601
<211>  1719
<212>  DNA
<213>  Homo sapiens;

<400>  601
atggcggccc cccgcccgtc tcccgcgatc tccgtttcgg tctcggctcc ggctttttac       60

gccccgcaga agaagttcgg ccctgtggtg gccccaaagc ccaaagtgaa tcccttccgg      120

cccggggaca gcgagcctcc cccggcaccc ggggcccagc gcgcacagat gggccgggtg      180

ggcgagattc ccccgccgcc cccggaagac tttcccctgc ctccacctcc ccttgctggg      240

gatggcgacg atgcagaggg tgctctggga ggtgccttcc cgccgccccc tcccccgatc      300

gaggaatcat ttccccctgc gcctctggag gaggagatct tcccttcccc gccgcctcct      360

ccggaggagg agggagggcc tgaggccccc ataccgcccc caccacagcc cagggagaag      420

gtgagcagta ttgatttgga gatcgactct ctgtcctcac tgctggatga catgaccaag      480

aatgatcctt tcaaagcccg ggtgtcatct ggatatgtgc ccccaccagt ggccactcca      540

ttcagttcca agtccagtac caagcctgca gccgggggca cagcacccct gcctccttgg      600

aagtcccctt ccagctccca gcctctgccc caggttccgg ctccggctca gagccagaca      660

cagttccatg ttcagcccca gccccagccc aagcctcagg tccaactcca tgtccagtcc      720

cagacccagc ctgtgtcttt ggctaacacc cagccccgag ggcccccagc ctcatctccg      780

gctccagccc ctaagttttc tccagtgact cctaagttta ctcctgtggc ttccaagttc      840

agtcctggag ccccaggtgg atctgggtca caaccaaatc aaaaattggg gcaccccgaa      900

gctctttctg ctggcacagg ctcccctcaa cctcccagct tcacctatgc ccagcagagg      960

gagaagcccc gagtgcagga gaagcagcac cccgtgcccc caccggctca gaaccaaaac     1020

caggtgcgct cccctggggc cccagggccc ctgactctga aggaggtgga ggagctggag     1080

cagctgaccc agcagctaat gcaggacatg gagcatcctc agaggcagaa tgtggctgtc     1140

aacgaactct gcggccgatg ccatcaaccc ctggcccggg cgcagccagc cgtccgcgct     1200

ctagggcagc tgttccacat cgcctgcttc acctgccacc agtgtgcgca gcagctccag     1260

ggccagcagt tctacagtct ggagggggcg ccgtactgcg agggctgtta cactgacacc     1320

ctggagaagt gtaacacctg cggggagccc atcactgacc gcatgctgag ggccacgggc     1380

aaggcctatc acccgcactg cttcacctgt gtggtctgcg cccgccccct ggagggcacc     1440

tccttcatcg tggaccaggc caaccggccc cactgtgtcc ccgactacca caagcagtac     1500

gccccgaggt gctccgtctg ctctgagccc atcatgcctg agcctggccg agatgagact     1560

gtgcgagtgg tcgccctgga caagaacttc cacatgaagt gttacaagtg tgaggactgc     1620

gggaagcccc tgtcgattga ggcagatgac aatggctgct tccccctgga cggtcacgtg     1680

ctctgtcgga agtgccacac tgctagagcc cagacctga                            1719


<210>  602
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Ala Ser Met Leu Leu Ala Gln Arg Leu Ala Cys Ser Phe Gln His 
1               5                   10                  15      


Ser Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Gln Glu Leu Met Lys Gln Leu Asn Ile 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Ser His Pro Ala Leu 
            100                 105                 110         


Leu Lys Leu Ile Gln Gln Pro Gln Asn Ala Ser Met Phe Val Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Glu Lys Leu Arg 
    130                 135                 140                 


Gln Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Leu Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Gln Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Ala Ala His Ala Gly Lys Ala Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Asp Ser 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  603
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  603

Met Asn Ala Met Leu Glu Thr Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Thr Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Thr Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Thr 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Thr Met Ser Asp Gly Ala Thr Ser Thr Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Thr Met 
        115                 120                 125             


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140                 


Thr Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160 


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Thr Ser Pro Arg Met 
                165                 170                 175     


Phe Thr Tyr Gly Cys Thr Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190         


Lys Lys Thr Tyr Pro Leu Thr Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205             


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Thr Gln Ala Asn Gln 
    210                 215                 220                 


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240 


Arg Ala Gln Glu Thr Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255     


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270         


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285             


Thr Asp Leu Ser Arg Leu Tyr Thr Ala Thr Ser Leu Met Gln Ile Asp 
    290                 295                 300                 


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320 


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335     


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350         


Leu Thr Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365             


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380                 


Leu Phe Pro Glu Pro Leu Thr Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400 


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415     


Thr Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425 


<210>  604
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  604

Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Thr Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Thr Gly Thr Leu Ser Arg Thr Asn Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Thr Leu 
            180                 185                 190         


Gly Arg Asn Thr Pro Tyr Lys Thr Leu Glu Pro Val Lys Pro Pro Thr 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Thr Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Thr Ala Ser Leu Asn Gln Arg Pro Arg Thr His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Thr Pro Ser Pro Pro Thr Ile Gly 
            260                 265                 270         


Pro Glu Asn Ile Ser Val Pro Pro Pro Ser Gly Ala Pro Pro Ala Pro 
        275                 280                 285             


Pro Leu Ala Pro Leu Leu Pro Val Ser Thr Val Ile Ala Ala Pro Gly 
    290                 295                 300                 


Ser Ala Pro Gly Ser Gln Tyr Gly Thr Met Thr Arg Gln Ile Ser Arg 
305                 310                 315                 320 


His Asn Ser Thr Thr Ser Ser Thr Ser Ser Gly Gly Tyr Arg Arg Thr 
                325                 330                 335     


Pro Ser Val Thr Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly Gly 
            340                 345                 350         


Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Met Pro Gln Leu Thr Pro Gln Ile Pro Leu Thr Gly Phe Val Ala Arg 
    370                 375                 380                 


Val Gln Glu Asn Ile Ala Asp Ser Pro Thr Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn 
            420                 425                 430         


Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile 
        435                 440                 445             


Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Asp Asp Glu 
    450                 455                 460                 


Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp 
465                 470                 475                 480 


Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Thr Gly Leu Phe Pro 
                485                 490                 495     


Gly Asn Tyr Val Glu Ser Ile Met His Tyr Thr Asp 
            500                 505             


<210>  605
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  605

Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro Thr Arg Thr Ser 
            340                 345                 350         


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
        355                 360                 365             


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
    370                 375                 380                 


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
385                 390                 395                 400 


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
                405                 410                 415     


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
            420                 425                 430         


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
        435                 440                 445             


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
    450                 455                 460                 


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
465                 470                 475                 480 


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
                485                 490                 495     


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
            500                 505                 510         


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
        515                 520                 525             


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
    530                 535                 540                 


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
                565                 570                 575     


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
            580                 585                 590         


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
        595                 600                 605             


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
    610                 615                 620                 


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
625                 630                 635                 640 


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
                645                 650                 655     


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
            660                 665                 670         


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr 
        675                 680                 685             


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
    690                 695                 700                 


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
705                 710                 715                 720 


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
                725                 730                 735     


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
            740                 745                 750         


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
        755                 760                 765             


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    770                 775             


<210>  606
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 
1               5                   10                  15      


Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 
            20                  25                  30          


Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 
        35                  40                  45              


Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 
    50                  55                  60                  


Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 
65                  70                  75                  80  


Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 
                85                  90                  95      


Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 
            100                 105                 110         


Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 
        115                 120                 125             


Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 
    130                 135                 140                 


Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn 
145                 150                 155                 160 


Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp 
                165                 170                 175     


Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe 
            180                 185                 190         


Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln 
        195                 200                 205             


Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val 
    210                 215                 220                 


Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile 
225                 230                 235                 240 


Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly 
                245                 250                 255     


Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala 
            260                 265                 270         


Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala 
        275                 280                 285             


Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu 
    290                 295                 300                 


Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly 
305                 310                 315                 320 


Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val 
                325                 330                 335     


Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala 
            340                 345                 350         


Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro 
        355                 360                 365             


Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala 
    370                 375                 380                 


Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg 
385                 390                 395                 400 


Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala 
                405                 410                 415     


Ala Val Phe Glu Tyr Pro Gly Asn 
            420                 


<210>  607
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  607

Met Lys Met Thr Val Asp Phe Glu Glu Cys Leu Lys Asp Ser Pro Arg 
1               5                   10                  15      


Phe Arg Ala Ala Leu Glu Glu Val Glu Gly Asp Val Ala Glu Leu Glu 
            20                  25                  30          


Leu Lys Leu Asp Lys Leu Val Lys Leu Cys Ile Ala Met Ile Asp Thr 
        35                  40                  45              


Gly Lys Ala Phe Cys Val Ala Asn Lys Gln Phe Met Asn Gly Ile Arg 
    50                  55                  60                  


Asp Leu Ala Gln Tyr Ser Ser Asn Asp Ala Val Val Glu Thr Ser Leu 
65                  70                  75                  80  


Thr Lys Phe Ser Asp Ser Leu Gln Glu Met Ile Asn Phe His Thr Ile 
                85                  90                  95      


Leu Phe Asp Gln Thr Gln Arg Ser Ile Lys Ala Gln Leu Gln Asn Phe 
            100                 105                 110         


Val Lys Glu Asp Leu Arg Lys Phe Lys Asp Ala Lys Lys Gln Phe Glu 
        115                 120                 125             


Lys Val Ser Glu Glu Lys Glu Asn Ala Leu Val Lys Asn Ala Gln Val 
    130                 135                 140                 


Gln Arg Asn Lys Gln His Glu Val Glu Glu Ala Thr Asn Ile Leu Thr 
145                 150                 155                 160 


Ala Thr Arg Lys Cys Phe Arg His Ile Ala Leu Asp Tyr Val Leu Gln 
                165                 170                 175     


Ile Asn Val Leu Gln Ser Lys Arg Arg Ser Glu Ile Leu Lys Ser Met 
            180                 185                 190         


Leu Ser Phe Met Tyr Ala His Leu Ala Phe Phe His Gln Gly Tyr Asp 
        195                 200                 205             


Leu Phe Ser Glu Leu Gly Pro Tyr Met Lys Asp Leu Gly Ala Gln Leu 
    210                 215                 220                 


Asp Arg Leu Val Val Asp Ala Ala Lys Glu Lys Arg Glu Met Glu Gln 
225                 230                 235                 240 


Lys His Ser Thr Ile Gln Gln Lys Asp Phe Ser Ser Asp Asp Ser Lys 
                245                 250                 255     


Leu Glu Tyr Asn Val Asp Ala Ala Asn Gly Ile Val Met Glu Gly Tyr 
            260                 265                 270         


Leu Phe Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn Arg Arg Trp 
        275                 280                 285             


Phe Ser Ile Gln Asn Asn Gln Leu Val Tyr Gln Lys Lys Phe Lys Asp 
    290                 295                 300                 


Asn Pro Thr Val Val Val Glu Asp Leu Arg Leu Cys Thr Val Lys His 
305                 310                 315                 320 


Cys Glu Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Val Ser Pro Thr 
                325                 330                 335     


Lys Ser Cys Met Leu Gln Ala Asp Ser Glu Lys Leu Arg Gln Ala Trp 
            340                 345                 350         


Ile Lys Ala Val Gln Thr Ser Ile Ala Thr Ala Tyr Arg Glu Lys Gly 
        355                 360                 365             


Asp Glu Ser Glu Lys Leu Asp Lys Lys Ser Ser Pro Ser Thr Gly Ser 
    370                 375                 380                 


Leu Asp Ser Gly Asn Glu Ser Lys Glu Lys Leu Leu Lys Gly Glu Ser 
385                 390                 395                 400 


Ala Leu Gln Arg Val Gln Cys Ile Pro Gly Asn Ala Ser Cys Cys Asp 
                405                 410                 415     


Cys Gly Leu Ala Asp Pro Arg Trp Ala Ser Ile Asn Leu Gly Ile Thr 
            420                 425                 430         


Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Val His Phe 
        435                 440                 445             


Ser Lys Val Arg Ser Leu Thr Leu Asp Thr Trp Glu Pro Glu Leu Leu 
    450                 455                 460                 


Lys Leu Met Cys Glu Leu Gly Asn Asp Val Ile Asn Arg Val Tyr Glu 
465                 470                 475                 480 


Ala Asn Val Glu Lys Met Gly Ile Lys Lys Pro Gln Pro Gly Gln Arg 
                485                 490                 495     


Gln Glu Lys Glu Ala Tyr Ile Arg Ala Lys Tyr Val Glu Arg Lys Phe 
            500                 505                 510         


Val Asp Lys Tyr Ser Ile Ser Leu Ser Pro Pro Glu Gln Gln Lys Lys 
        515                 520                 525             


Phe Val Ser Lys Ser Ser Glu Glu Lys Arg Leu Ser Ile Ser Lys Phe 
    530                 535                 540                 


Gly Pro Gly Asp Gln Val Arg Ala Ser Ala Gln Ser Ser Val Arg Ser 
545                 550                 555                 560 


Asn Asp Ser Gly Ile Gln Gln Ser Ser Asp Asp Gly Arg Glu Ser Leu 
                565                 570                 575     


Pro Ser Thr Val Ser Ala Asn Ser Leu Tyr Glu Pro Glu Gly Glu Arg 
            580                 585                 590         


Gln Asp Ser Ser Met Phe Leu Asp Ser Lys His Leu Asn Pro Gly Leu 
        595                 600                 605             


Gln Leu Tyr Arg Ala Ser Tyr Glu Lys Asn Leu Pro Lys Met Ala Glu 
    610                 615                 620                 


Ala Leu Ala His Gly Ala Asp Val Asn Trp Ala Asn Ser Glu Glu Asn 
625                 630                 635                 640 


Lys Ala Thr Pro Leu Ile Gln Ala Val Leu Gly Gly Ser Leu Val Thr 
                645                 650                 655     


Cys Glu Phe Leu Leu Gln Asn Gly Ala Asn Val Asn Gln Arg Asp Val 
            660                 665                 670         


Gln Gly Arg Gly Pro Leu His His Ala Thr Val Leu Gly His Thr Gly 
        675                 680                 685             


Gln Val Cys Leu Phe Leu Lys Arg Gly Ala Asn Gln His Ala Thr Asp 
    690                 695                 700                 


Glu Glu Gly Lys Asp Pro Leu Ser Ile Ala Val Glu Ala Ala Asn Ala 
705                 710                 715                 720 


Asp Ile Val Thr Leu Leu Arg Leu Ala Arg Met Asn Glu Glu Met Arg 
                725                 730                 735     


Glu Ser Glu Gly Leu Tyr Gly Gln Pro Gly Asp Glu Thr Tyr Gln Asp 
            740                 745                 750         


Ile Phe Arg Asp Phe Ser Gln Met Ala Ser Asn Asn Pro Glu Lys Leu 
        755                 760                 765             


Asn Arg Phe Gln Gln Asp Ser Gln Lys Phe 
    770                 775             


<210>  608
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Thr Ser Cys Leu Gln Ala Asn Tyr Thr Cys Glu Thr 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Thr Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys 
                85                  90                  95      


Tyr Thr Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Thr Leu Gln Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Thr Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Thr Asp Thr Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Thr Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Ala Leu Arg Val Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn 
465                 470                 475                 480 


Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln 
                485                 490                 495     


Leu Ser Val Gln Glu Asp Val Lys Ile 
            500                 505 


<210>  609
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  609

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  610
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  610

Met Glu Leu Glu Val Arg Arg Val Arg Gln Ala Phe Leu Ser Gly Arg 
1               5                   10                  15      


Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
            20                  25                  30          


Met Val Gln Glu Arg Glu Lys Asp Ile Leu Thr Ala Ile Ala Ala Asp 
        35                  40                  45              


Leu Cys Lys Ser Glu Phe Asn Val Tyr Ser Gln Glu Val Ile Thr Val 
    50                  55                  60                  


Leu Gly Glu Ile Asp Phe Met Leu Glu Asn Leu Pro Glu Trp Val Thr 
65                  70                  75                  80  


Ala Lys Pro Val Lys Lys Asn Val Leu Thr Met Leu Asp Glu Ala Tyr 
                85                  90                  95      


Ile Gln Pro Gln Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
            100                 105                 110         


Tyr Pro Phe Val Leu Thr Ile Gln Pro Leu Ile Gly Ala Ile Ala Ala 
        115                 120                 125             


Gly Asn Ala Val Ile Ile Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
    130                 135                 140                 


Lys Ile Leu Ala Lys Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
145                 150                 155                 160 


Ile Val Ile Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Lys Gln 
                165                 170                 175     


Arg Phe Asp His Ile Phe Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
            180                 185                 190         


Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
        195                 200                 205             


Gly Gly Lys Ser Pro Cys Tyr Ile Asp Lys Asp Cys Asp Leu Asp Ile 
    210                 215                 220                 


Val Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
225                 230                 235                 240 


Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Leu Gln Asn Gln 
                245                 250                 255     


Ile Val Trp Lys Ile Lys Glu Thr Val Lys Glu Phe Tyr Gly Glu Asn 
            260                 265                 270         


Ile Lys Glu Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
        275                 280                 285             


Lys Arg Ile Leu Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
    290                 295                 300                 


Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Val Leu Thr Asp 
305                 310                 315                 320 


Val Asp Pro Lys Thr Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                325                 330                 335     


Leu Pro Ile Val Pro Val Lys Asn Val Asp Glu Ala Ile Asn Phe Ile 
            340                 345                 350         


Asn Glu Arg Glu Lys Pro Leu Ala Leu Tyr Val Phe Ser His Asn His 
        355                 360                 365             


Lys Leu Ile Lys Arg Met Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
    370                 375                 380                 


Gly Asn Asp Val Ile Met His Phe Thr Leu Asn Ser Phe Pro Phe Gly 
385                 390                 395                 400 


Gly Val Gly Ser Ser Gly Met Gly Ala Tyr His Gly Lys His Ser Phe 
                405                 410                 415     


Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Ser Leu Lys Arg 
            420                 425                 430         


Glu Gly Ala Asn Lys Leu Arg Tyr Pro Pro Asn Ser Gln Ser Lys Val 
        435                 440                 445             


Asp Trp Gly Lys Phe Phe Leu Leu Lys Arg Phe Asn Lys Glu Lys Leu 
    450                 455                 460                 


Gly Leu Leu Leu Leu Thr Phe Leu Gly Ile Val Ala Ala Val Leu Val 
465                 470                 475                 480 


Lys Ala Glu Tyr Tyr 
                485 


<210>  611
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  611

Met Glu Lys Glu Lys Gly Asn Asp Asp Gly Ile Pro Asp Gln Glu Asn 
1               5                   10                  15      


Ser Leu Asp Phe Ser Glu His Phe Asn Gln Leu Glu Leu Leu Glu Thr 
            20                  25                  30          


His Gly His Leu Ile Pro Thr Gly Thr Gln Ser Leu Trp Val Gly Asn 
        35                  40                  45              


Ser Asp Glu Asp Glu Glu Gln Asp Asp Lys Asn Glu Glu Trp Tyr Arg 
    50                  55                  60                  


Leu Gln Glu Lys Lys Met Glu Lys Asp Pro Ser Arg Leu Leu Leu Trp 
65                  70                  75                  80  


Ala Ala Glu Lys Asn Arg Leu Thr Thr Val Arg Arg Leu Leu Ser Glu 
                85                  90                  95      


Lys Ala Thr His Val Asn Thr Arg Asp Glu Asp Glu Tyr Thr Pro Leu 
            100                 105                 110         


His Arg Ala Ala Tyr Ser Gly His Leu Asp Ile Val Gln Glu Leu Ile 
        115                 120                 125             


Ala Gln Gly Ala Asp Val His Ala Val Thr Val Asp Gly Trp Thr Pro 
    130                 135                 140                 


Leu His Ser Ala Cys Lys Trp Asn Asn Thr Arg Val Ala Ser Phe Leu 
145                 150                 155                 160 


Leu Gln His Asp Ala Asp Ile Asn Ala Gln Thr Lys Gly Leu Leu Thr 
                165                 170                 175     


Pro Leu His Leu Ala Ala Gly Asn Arg Asp Ser Lys Asp Thr Leu Glu 
            180                 185                 190         


Leu Leu Leu Met Asn Arg Tyr Val Lys Pro Gly Leu Lys Asn Asn Leu 
        195                 200                 205             


Glu Glu Thr Ala Phe Asp Ile Ala Arg Arg Thr Ser Ile Tyr His Tyr 
    210                 215                 220                 


Leu Phe Glu Ile Val Glu Gly Cys Thr Asn Ser Ser Pro Gln Ser 
225                 230                 235                 


<210>  612
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Gly Cys Val Leu Val Val 
        35                  40                  45              


Ser Val Ile Glu Gln Leu Ala Gln Val His Asn Ser Thr Val Gln Ala 
    50                  55                  60                  


Ser Met Glu Arg Leu Cys Ser Tyr Leu Pro Glu Lys Leu Phe Leu Lys 
65                  70                  75                  80  


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
                85                  90                  95      


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
            100                 105                 110         


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
        115                 120                 125             


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
    130                 135                 140                 


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
145                 150                 155                 160 


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
                165                 170                 175     


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
            180                 185                 190         


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
        195                 200                 205             


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
    210                 215                 220                 


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
225                 230                 235                 240 


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
                245                 250                 255     


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
            260                 265                 270         


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
        275                 280                 285             


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
    290                 295                 300                 


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
305                 310                 315                 320 


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
                325                 330                 335     


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
            340                 345                 350         


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
        355                 360                 365             


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
    370                 375                 380                 


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
385                 390                 395                 400 


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
                405                 410                 415     


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
            420                 425                 430         


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
        435                 440                 445             


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
    450                 455                 460                 


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
465                 470                 475                 480 


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
                485                 490                 495     


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
            500                 505                 510         


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
        515                 520                 525             


Phe His Pro Asn Glu Val Ala Leu Leu Leu Leu Ala Asp His Phe Trp 
    530                 535                 540                 


Lys Lys Val Gln Leu Gln Trp Pro Gln Ile Leu Gly Lys Glu Asn Pro 
545                 550                 555                 560 


Phe Asn Pro Gln Ile Lys Gln Val Phe Gly Asp Gln Gly Gly His 
                565                 570                 575 


<210>  613
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  613

Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Thr Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Thr Gln Ser Leu Gly Val Asp Thr Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Thr Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Thr Asn Val Ala Ala Thr Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Glu Glu Glu Glu Ala Gln Ala Lys Ala 
145                 150                 155                 160 


Asp Lys Ile Lys Leu Ala Leu Glu Lys Leu Lys Glu Ala Lys Val Lys 
                165                 170                 175     


Lys Leu Val Val Lys Val His Met Asn Asp Asn Ser Thr Lys Ser Leu 
            180                 185                 190         


Met Val Asp Glu Arg Gln Leu Ala Arg Asp Val Leu Asp Asn Leu Phe 
        195                 200                 205             


Glu Lys Thr His Cys Asp Cys Asn Val Asp Trp Cys Leu Tyr Glu Ile 
    210                 215                 220                 


Tyr Pro Glu Leu Gln Ile Glu Arg Phe Phe Glu Asp His Glu Asn Val 
225                 230                 235                 240 


Val Glu Val Leu Ser Asp Trp Thr Arg Asp Thr Glu Asn Lys Ile Leu 
                245                 250                 255     


Phe Leu Glu Lys Glu Glu Lys Tyr Ala Val Phe Lys Asn Pro Gln Asn 
            260                 265                 270         


Phe Tyr Leu Asp Asn Arg Gly Lys Lys Glu Ser Lys Glu Thr Asn Glu 
        275                 280                 285             


Lys Met Asn Ala Lys Asn Lys Glu Ser Leu Leu Glu Glu Ser Phe Cys 
    290                 295                 300                 


Gly Thr Ser Ile Ile Val Pro Glu Leu Glu Gly Ala Leu Tyr Leu Lys 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Ser Trp Lys Arg Arg Tyr Phe Leu Leu Arg Ala 
                325                 330                 335     


Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys Thr Lys Thr Ser Arg Asp 
            340                 345                 350         


Leu Ala Cys Phe Ile Gln Phe Glu Asn Val Asn Ile Tyr Tyr Gly Thr 
        355                 360                 365             


Gln His Lys Met Lys Tyr Lys Ala Pro Thr Asp Tyr Cys Phe Val Leu 
    370                 375                 380                 


Lys His Pro Gln Ile Gln Lys Glu Ser Gln Tyr Ile Lys Tyr Leu Cys 
385                 390                 395                 400 


Cys Asp Asp Thr Arg Thr Leu Asn Gln Trp Val Met Gly Ile Arg Ile 
                405                 410                 415     


Ala Lys Tyr Gly Lys Thr Leu Tyr Asp Asn Tyr Gln Arg Ala Val Ala 
            420                 425                 430         


Lys Ala Gly Leu Ala Ser Arg Trp Thr Asn Leu Gly Thr Val Asn Ala 
        435                 440                 445             


Ala Ala Pro Ala Gln Pro Ser Thr Gly Pro Lys Thr Gly Thr Thr Gln 
    450                 455                 460                 


Pro Asn Gly Gln Ile Pro Gln Ala Thr His Ser Val Ser Ala Val Leu 
465                 470                 475                 480 


Gln Glu Ala Gln Arg His Ala Glu Thr Ser Lys Asp Lys Lys Pro Ala 
                485                 490                 495     


Leu Gly Asn His His Asp Pro Ala Val Pro Arg Ala Pro His Ala Pro 
            500                 505                 510         


Lys Ser Ser Leu Pro Pro Pro Pro Pro Val Arg Arg Ser Ser Asp Thr 
        515                 520                 525             


Ser Gly Ser Pro Ala Thr Pro Leu Lys Ala Lys Gly Thr Gly Gly Gly 
    530                 535                 540                 


Gly Leu Pro Ala Pro Pro Asp Asp Phe Leu Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Leu Asp Asp Pro Glu Leu Pro Pro Pro Pro Pro Asp Phe Met 
                565                 570                 575     


Glu Pro Pro Pro Asp Phe Val Pro Pro Pro Pro Pro Ser Tyr Ala Gly 
            580                 585                 590         


Ile Ala Gly Ser Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro 
        595                 600                 605             


Ala Pro Ala Pro Val Pro Asp Ser Ala Arg Pro Pro Pro Ala Val Ala 
    610                 615                 620                 


Lys Arg Pro Pro Val Pro Pro Lys Arg Gln Glu Asn Pro Gly His Pro 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Gly Glu Gln Asp Phe Met Ser Asp Leu Met Lys 
                645                 650                 655     


Ala Leu Gln Lys Lys Arg Gly Asn Val Ser 
            660                 665     


<210>  614
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
    610                 615                 620                 


Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
625                 630                 635                 640 


Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                645                 650                 655     


Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
            660                 665                 670         


Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
        675                 680                 685             


Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
    690                 695                 700                 


Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
705                 710                 715                 720 


Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr 
                725                 730                 735     


Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
            740                 745                 750         


Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760             


<210>  615
<211>  1205
<212>  PRT
<213>  Homo sapiens

<400>  615

Met Thr Lys Lys Glu Glu Pro Pro Pro Ser Arg Val Pro Arg Ala Val 
1               5                   10                  15      


Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu Leu Ser Gly Asp Asp 
            20                  25                  30          


Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr Glu Gly Val Pro Asn 
        35                  40                  45              


Gly Gly Trp His Thr Ser Ser Leu Ser Leu Ser Leu Pro Ser Thr Ile 
    50                  55                  60                  


Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly Gly Ser Thr Pro Val 
65                  70                  75                  80  


Thr Pro Val Ile Lys Ala Gly Trp Leu Asp Lys Asn Pro Pro Gln Gly 
                85                  90                  95      


Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu Asp Thr Asp His Leu 
            100                 105                 110         


Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser Lys Arg Phe Ile Ser 
        115                 120                 125             


Val Ala Cys Ile Ser His Val Ala Ala Ile Gly Asp Gln Lys Phe Glu 
    130                 135                 140                 


Val Ile Thr Asn Asn Arg Thr Phe Ala Phe Arg Ala Glu Ser Asp Val 
145                 150                 155                 160 


Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln Ala Met Ala Glu Gln 
                165                 170                 175     


Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu Leu Gly Val Pro Gly 
            180                 185                 190         


Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu Leu Arg Gly Phe Lys 
        195                 200                 205             


Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys Val Gln Leu Tyr Lys 
    210                 215                 220                 


Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile Thr Phe Ile Asp Met 
225                 230                 235                 240 


Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg Ser Phe Asp Leu Thr 
                245                 250                 255     


Thr Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp Ser Glu Leu Glu Lys 
            260                 265                 270         


Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile Ala Glu Ala Leu Ser 
        275                 280                 285             


Thr Ser Glu Val Ala Glu Arg Ile Trp Ala Ala Ala Pro Asn Arg Phe 
    290                 295                 300                 


Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu His Arg Gly Leu Gly 
                325                 330                 335     


Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met Asp Arg Lys Val Trp 
            340                 345                 350         


Thr Glu Thr Leu Ile Glu Leu Phe Leu Gln Leu Gly Asn Gly Ala Gly 
        355                 360                 365             


Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser Glu Ala Leu Gln Pro 
    370                 375                 380                 


Ser Ser Ser Pro Ser Thr Arg Arg Cys His Leu Glu Ala Lys Tyr Arg 
385                 390                 395                 400 


Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe Gly Asn Gln Glu Glu 
                405                 410                 415     


Leu Asp Lys Ala Leu Cys Ala Ala Val Thr Thr Thr Asp Leu Ala Glu 
            420                 425                 430         


Thr Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile Asn Cys Phe Ser Gly 
        435                 440                 445             


Asp Pro Glu Ala Pro Thr Pro Leu Ala Leu Ala Glu Gln Ala Gly Gln 
    450                 455                 460                 


Thr Leu Gln Met Glu Phe Leu Arg Asn Asn Arg Thr Thr Glu Val Pro 
465                 470                 475                 480 


Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu 
                485                 490                 495     


Pro Thr Val Ser His Ser Gly Phe Leu Tyr Lys Thr Ala Ser Ala Gly 
            500                 505                 510         


Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp 
        515                 520                 525             


Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala 
    530                 535                 540                 


Val Thr Pro Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala 
545                 550                 555                 560 


Val Pro Pro Pro Asp Thr His Gly Phe Glu His Thr Phe Glu Val Tyr 
                565                 570                 575     


Thr Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln 
            580                 585                 590         


Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu 
        595                 600                 605             


Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro 
    610                 615                 620                 


Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser 
625                 630                 635                 640 


Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu 
                645                 650                 655     


Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp 
            660                 665                 670         


Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg Arg Arg Thr Leu Tyr 
        675                 680                 685             


Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile 
    690                 695                 700                 


Gln Lys Ala Ala Ala Ser Met Gly Asp Thr Leu Ser Glu Gln Gln Leu 
705                 710                 715                 720 


Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile 
                725                 730                 735     


Thr Gln Cys Gly Leu Thr Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln 
            740                 745                 750         


Thr Ser Lys Thr Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg 
        755                 760                 765             


Ser Val His Leu Lys Glu Gly Glu Gln His Val Asp Asp Val Ser Ser 
    770                 775                 780                 


Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu Phe Thr Arg 
785                 790                 795                 800 


Ala Gln Arg Leu Thr Trp Leu Glu Ala Ser Glu Ile Glu Asp Glu Glu 
                805                 810                 815     


Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu Pro Pro Val 
            820                 825                 830         


Asn Arg Ala Thr Val Lys Ala Leu Ile Ser His Leu Tyr Cys Val Gln 
        835                 840                 845             


Cys Phe Ser Asp Thr Asn Gln Met Asn Val His Asn Leu Ala Ile Val 
    850                 855                 860                 


Phe Gly Pro Thr Leu Phe Gln Thr Asp Gly Gln Asp Tyr Lys Ala Gly 
865                 870                 875                 880 


Arg Val Val Glu Asp Leu Ile Asn His Tyr Val Val Val Phe Ser Val 
                885                 890                 895     


Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu Ile Thr Ala Ile Val 
            900                 905                 910         


Lys Met Arg Val Ala Gly Thr Ala Ser Gly Thr Gln His Ala Gly Asp 
        915                 920                 925             


Phe Ile Cys Thr Val Tyr Leu Glu Glu Lys Lys Ala Glu Thr Glu Gln 
    930                 935                 940                 


His Ile Lys Val Pro Ala Ser Met Thr Ala Glu Glu Leu Thr Leu Glu 
945                 950                 955                 960 


Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu Lys Asp Tyr Trp Thr 
                965                 970                 975     


Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu Arg Pro Leu His Phe 
            980                 985                 990         


Ala Glu Lys Val Leu Pro Ile Leu  His Gly Leu Gly Thr  Asp Ser His 
        995                 1000                 1005             


Leu Val  Val Lys Lys His Gln  Ala Met Glu Ala Met  Leu Leu Tyr 
    1010                 1015                 1020             


Leu Ala  Ser Arg Val Gly Asp  Thr Lys His Gly Met  Met Lys Phe 
    1025                 1030                 1035             


Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly Leu Pro  Ser Gly Gly 
    1040                 1045                 1050             


Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser Ser Cys  Leu Arg Leu 
    1055                 1060                 1065             


Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp Ser Gly  Ala Pro Glu 
    1070                 1075                 1080             


Thr Ser  His Arg Pro Glu Lys  Glu Trp Pro Ile Lys  Ser Leu Lys 
    1085                 1090                 1095             


Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg Pro Pro  Thr Cys Trp 
    1100                 1105                 1110             


Gly Phe  Thr Val Val His Glu  Thr Glu Lys His Glu  Lys Gln Gln 
    1115                 1120                 1125             


Trp Tyr  Leu Cys Cys Asp Thr  Gln Met Glu Leu Arg  Glu Trp Phe 
    1130                 1135                 1140             


Ala Thr  Phe Leu Phe Val Gln  His Asp Gly Leu Val  Trp Pro Ser 
    1145                 1150                 1155             


Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro Glu Val  Arg Leu Gly 
    1160                 1165                 1170             


Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser Glu Asn  Glu Met Arg 
    1175                 1180                 1185             


Arg Ser  Val Ala Ala Phe Thr  Ala Asp Pro Leu Ser  Leu Leu Arg 
    1190                 1195                 1200             


Asn Val  
    1205 


<210>  616
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  616

Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser 
1               5                   10                  15      


Thr Arg Gln Gly Thr Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn 
            20                  25                  30          


Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Thr Asp 
        35                  40                  45              


Val Gly Lys Val Thr Glu Pro Ile Ser Arg His Arg Arg Asn His Ser 
    50                  55                  60                  


Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val 
65                  70                  75                  80  


Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys 
                85                  90                  95      


Lys Leu Arg Lys Asn Trp Ser Thr Ser Trp Ile Val Leu Ser Ser Arg 
            100                 105                 110         


Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met 
        115                 120                 125             


Lys Thr Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile 
    130                 135                 140                 


Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Thr 
145                 150                 155                 160 


Thr Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile 
                165                 170                 175     


Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro 
            180                 185                 190         


Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln 
        195                 200                 205             


Arg Ser Ser Ser Thr Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys 
    210                 215                 220                 


Glu Gln Lys Pro Glu His Arg Lys Ser Leu Met Phe Arg Leu His His 
225                 230                 235                 240 


Ser Ala Ser Asp Thr Ser Asp Lys Asn Arg Val Lys Ser Arg Leu Lys 
                245                 250                 255     


Lys Phe Ile Thr Arg Arg Pro Ser Leu Lys Thr Leu Gln Glu Lys Gly 
            260                 265                 270         


Leu Ile Lys Asp Gln Ile Phe Gly Ser His Leu His Lys Val Cys Glu 
        275                 280                 285             


Arg Glu Asn Ser Thr Val Pro Trp Phe Val Lys Gln Cys Ile Glu Ala 
    290                 295                 300                 


Val Glu Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly 
305                 310                 315                 320 


Asn Leu Ala Thr Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Glu Glu 
                325                 330                 335     


Lys Leu Asn Leu Asp Asp Ser Gln Trp Glu Asp Ile His Val Val Thr 
            340                 345                 350         


Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
        355                 360                 365             


Tyr Ser Phe Phe Glu Gln Phe Val Glu Ala Ile Lys Lys Gln Asp Asn 
    370                 375                 380                 


Asn Thr Arg Ile Glu Ala Val Lys Ser Leu Val Gln Lys Leu Pro Pro 
385                 390                 395                 400 


Pro Asn Arg Asp Thr Met Lys Val Leu Phe Gly His Leu Thr Lys Ile 
                405                 410                 415     


Val Ala Lys Ala Ser Lys Asn Leu Met Ser Thr Gln Ser Leu Gly Ile 
            420                 425                 430         


Val Phe Gly Pro Thr Leu Leu Arg Ala Glu Asn Glu Thr Gly Asn Met 
        435                 440                 445             


Ala Ile His Met Val Tyr Gln Asn Gln Ile Ala Glu Leu Met Leu Ser 
    450                 455                 460                 


Glu Tyr Ser Lys Ile Phe Gly Ser Glu Glu Asp 
465                 470                 475 


<210>  617
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  617

Met Ser Leu Gly Gln Ser Ala Cys Leu Phe Leu Ser Ile Ala Arg Ser 
1               5                   10                  15      


Arg Ser Val Met Thr Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser 
            20                  25                  30          


Thr Pro Asn Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys 
        35                  40                  45              


Gln Arg Ser Ile Val Lys Asn Trp Gln Gln Arg Tyr Phe Val Leu Arg 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp Glu Glu Asp Thr Lys Pro Gln 
65                  70                  75                  80  


Gly Cys Met Tyr Leu Pro Gly Cys Thr Ile Lys Glu Ile Ala Thr Asn 
                85                  90                  95      


Pro Glu Glu Ala Gly Lys Phe Val Phe Glu Ile Ile Pro Ala Ser Trp 
            100                 105                 110         


Asp Gln Asn Arg Met Gly Gln Asp Ser Tyr Val Leu Met Ala Ser Ser 
        115                 120                 125             


Gln Ala Glu Met Glu Glu Trp Val Lys Phe Leu Arg Arg Val Ala Gly 
    130                 135                 140                 


Thr Pro Cys Gly Val Phe Gly Gln Arg Leu Asp Glu Thr Val Ala Tyr 
145                 150                 155                 160 


Glu Gln Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys Cys 
                165                 170                 175     


Ala Glu Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe Arg 
            180                 185                 190         


Leu Pro Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe Asp 
        195                 200                 205             


Ala Gly Glu Arg Pro Ser Phe Asp Arg Asp Thr Asp Val His Thr Val 
    210                 215                 220                 


Ala Ser Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val Val 
225                 230                 235                 240 


Pro Trp Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Thr Asn 
                245                 250                 255     


Ala Asp Glu Ala Lys Ala Gln Gln Glu Leu Met Lys Gln Leu Ser Ile 
            260                 265                 270         


Leu Pro Arg Asp Asn Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe Leu 
        275                 280                 285             


His Glu Ile Gln Leu Asn Cys Ala Val Asn Lys Met Ser Val Asp Asn 
    290                 295                 300                 


Leu Ala Thr Val Ile Gly Val Asn Leu Ile Arg Ser Lys Val Glu Asp 
305                 310                 315                 320 


Pro Ala Val Ile Met Arg Gly Thr Pro Gln Ile Gln Arg Val Met Thr 
                325                 330                 335     


Met Met Ile Arg Asp His Glu Val Leu Phe Pro Lys Ser Lys Asp Ile 
            340                 345                 350         


Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro Val 
        355                 360                 365             


Ala Arg Ser Ser Val Gly Trp Asp Ala Thr Glu Asp Leu Arg Ile Ser 
    370                 375                 380                 


Arg Thr Asp Ser Phe Ser Ser Met Thr Ser Asp Ser Asp Thr Thr Ser 
385                 390                 395                 400 


Pro Thr Gly Gln Gln Pro Ser Asp Ala Phe Pro Glu Asp Ser Ser Lys 
                405                 410                 415     


Val Pro Arg Glu Lys Pro Gly Asp Trp Lys Met Gln Ser Arg Lys Arg 
            420                 425                 430         


Thr Gln Thr Leu Pro Asn Arg Lys Cys Phe Leu Thr Ser Ala Phe Gln 
        435                 440                 445             


Gly Ala Asn Ser Ser Lys Met Glu Ile Phe Lys Asn Glu Phe Trp Ser 
    450                 455                 460                 


Pro Ser Ser Glu Ala Lys Ala Gly Glu Gly His Arg Arg Thr Met Ser 
465                 470                 475                 480 


Gln Asp Leu Arg Gln Leu Ser Asp Ser Gln Arg Thr Ser Thr Tyr Asp 
                485                 490                 495     


Asn Val Pro Ser Leu Pro Gly Ser Pro Gly Glu Glu Ala Ser Ala Leu 
            500                 505                 510         


Ser Ser Gln Ala Cys Asp Ser Lys Gly Asp Thr Leu Ala Ser Pro Asn 
        515                 520                 525             


Ser Glu Thr Gly Pro Gly Lys Lys Asn Ser Gly Glu Glu Glu Ile Asp 
    530                 535                 540                 


Ser Leu Gln Arg Met Val Gln Glu Leu Arg Lys Glu Ile Glu Thr Gln 
545                 550                 555                 560 


Lys Gln Met Tyr Glu Glu Gln Ile Lys Asn Leu Glu Lys Glu Asn Tyr 
                565                 570                 575     


Asp Val Trp Ala Lys Val Val Arg Leu Asn Glu Glu Leu Glu Lys Glu 
            580                 585                 590         


Lys Lys Lys Ser Ala Ala Leu Glu Ile Ser Leu Arg Asn Met Glu Arg 
        595                 600                 605             


Ser Arg Glu Asp Val Glu Lys Arg Asn Lys Ala Leu Glu Glu Glu Val 
    610                 615                 620                 


Lys Glu Phe Val Lys Ser Met Lys Glu Pro Lys Thr Glu Ala 
625                 630                 635             


<210>  618
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  618

Met Gly Leu Pro Ala Leu Glu Phe Ser Asp Cys Cys Leu Asp Ser Pro 
1               5                   10                  15      


His Phe Arg Glu Thr Leu Lys Ser His Glu Ala Glu Leu Asp Lys Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Ser Leu Ile Ser 
        35                  40                  45              


Ala Leu Lys Asn Leu Ser Ser Ala Lys Arg Lys Phe Ala Asp Ser Leu 
    50                  55                  60                  


Asn Glu Phe Lys Phe Gln Cys Ile Gly Asp Ala Glu Thr Asp Asp Glu 
65                  70                  75                  80  


Met Cys Ile Ala Arg Ser Leu Gln Glu Phe Ala Thr Val Leu Arg Asn 
                85                  90                  95      


Leu Glu Asp Glu Arg Ile Arg Met Ile Glu Asn Ala Ser Glu Val Leu 
            100                 105                 110         


Ile Thr Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Glu Ala Lys Lys Lys Tyr Asp Lys Glu Thr Glu Lys Tyr Cys Gly Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ser Gln Val Asp Leu Val Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Val Ser Leu Glu Tyr Val Phe Lys Val Gln Glu Val Gln Glu Arg Lys 
            180                 185                 190         


Met Phe Glu Phe Val Glu Pro Leu Leu Ala Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Thr Phe Tyr His His Gly Tyr Glu Leu Ala Lys Asp Phe Gly Asp Phe 
    210                 215                 220                 


Lys Thr Gln Leu Thr Ile Ser Ile Gln Asn Thr Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Thr Arg Ser Glu Val Glu Ser Leu Met Lys Lys Met Lys Glu Asn 
                245                 250                 255     


Pro Leu Glu His Lys Thr Ile Ser Pro Tyr Thr Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg His Phe Gly Thr Ser Trp Val Lys His Tyr 
        275                 280                 285             


Cys Thr Tyr Gln Arg Asp Ser Lys Gln Ile Thr Met Val Pro Phe Asp 
    290                 295                 300                 


Gln Lys Ser Gly Gly Lys Gly Gly Glu Asp Glu Ser Val Ile Leu Lys 
305                 310                 315                 320 


Ser Cys Thr Arg Arg Lys Thr Asp Ser Ile Glu Lys Arg Phe Cys Phe 
                325                 330                 335     


Asp Val Glu Ala Val Asp Arg Pro Gly Val Ile Thr Met Gln Ala Leu 
            340                 345                 350         


Ser Glu Glu Asp Arg Arg Leu Trp Met Glu Ala Met Asp Gly Arg Glu 
        355                 360                 365             


Pro Val Tyr Asn Ser Asn Lys Asp Ser Gln Ser Glu Gly Thr Ala Gln 
    370                 375                 380                 


Leu Asp Ser Ile Gly Phe Ser Ile Ile Arg Lys Cys Ile His Ala Val 
385                 390                 395                 400 


Glu Thr Arg Gly Ile Asn Glu Gln Gly Leu Tyr Arg Ile Val Gly Val 
                405                 410                 415     


Asn Ser Arg Val Gln Lys Leu Leu Ser Val Leu Met Asp Pro Lys Thr 
            420                 425                 430         


Ala Ser Glu Thr Glu Thr Asp Ile Cys Ala Glu Trp Glu Ile Lys Thr 
        435                 440                 445             


Ile Thr Ser Ala Leu Lys Thr Tyr Leu Arg Met Leu Pro Gly Pro Leu 
    450                 455                 460                 


Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala Ala Lys Leu Glu 
465                 470                 475                 480 


Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu Val His Arg Leu 
                485                 490                 495     


Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met Asn His Leu Ala 
            500                 505                 510         


Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Thr Val Ala Asn Leu 
        515                 520                 525             


Gly Val Val Phe Gly Pro Thr Leu Leu Arg Pro Gln Glu Glu Thr Val 
    530                 535                 540                 


Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val Ile Glu Ile Leu 
545                 550                 555                 560 


Ile Glu Asn His Glu Lys Ile Phe Asn Thr Val Pro Asp Met Pro Leu 
                565                 570                 575     


Thr Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser Ser Asp Ser Lys 
            580                 585                 590         


Pro Pro Ser Cys Ser Glu Arg Pro Leu Thr Leu Phe His Thr Val Gln 
        595                 600                 605             


Ser Thr Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile Asn Ser Ser Leu 
    610                 615                 620                 


Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn Ser Ser Ser Ser 
625                 630                 635                 640 


Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu Ala Val Val Lys 
                645                 650                 655     


Pro Thr Arg Pro Asn Ser Leu Pro Pro Asn Pro Ser Pro Thr Ser Pro 
            660                 665                 670         


Leu Ser Pro Ser Trp Pro Met Phe Ser Ala Pro Ser Ser Pro Met Pro 
        675                 680                 685             


Thr Ser Ser Thr Ser Ser Asp Ser Ser Pro Val Arg Ser Val Ala Gly 
    690                 695                 700                 


Phe Val Trp Phe Ser Val Ala Ala Val Val Leu Ser Leu Ala Arg Ser 
705                 710                 715                 720 


Ser Leu His Ala Val Phe Ser Leu Leu Val Asn Phe Val Pro Cys His 
                725                 730                 735     


Pro Asn Leu His Leu Leu Phe Asp Arg Pro Glu Glu Ala Val His Glu 
            740                 745                 750         


Asp Ser Ser Thr Pro Phe Arg Lys Ala Lys Ala Leu Tyr Ala Cys Lys 
        755                 760                 765             


Ala Glu His Asp Ser Glu Leu Ser Phe Thr Ala Gly Thr Val Phe Asp 
    770                 775                 780                 


Asn Val His Pro Ser Gln Glu Pro Gly Trp Leu Glu Gly Thr Leu Asn 
785                 790                 795                 800 


Gly Lys Thr Gly Leu Ile Pro Glu Asn Tyr Val Glu Phe Leu 
                805                 810                 


<210>  619
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  619

Met Lys Glu Ala Lys Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr 
1               5                   10                  15      


Thr Ile Ser Val Ser Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser 
            20                  25                  30          


Ile Thr Ala Lys Glu Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile 
        35                  40                  45              


His Asn Arg Cys Lys Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln 
    50                  55                  60                  


Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser 
65                  70                  75                  80  


Val Ser Leu Arg Ser Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala 
                85                  90                  95      


Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg 
            100                 105                 110         


Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile 
        115                 120                 125             


Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu 
    130                 135                 140                 


Ser Gln Ser Thr Asp Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val 
145                 150                 155                 160 


Glu Ser Leu Ile Asp Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp 
                165                 170                 175     


Phe Glu Met Asp Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala 
            180                 185                 190         


Val Asp Ser Ser Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln 
        195                 200                 205             


Gln Asp Val Ile Tyr Glu Leu Ile Gln Thr Glu Leu His His Val Arg 
    210                 215                 220                 


Thr Leu Lys Ile Met Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu 
225                 230                 235                 240 


Leu His Leu Glu Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp 
                245                 250                 255     


Glu Leu Ser Asp Ile His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg 
            260                 265                 270         


Arg Arg Gln Ala Leu Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His 
        275                 280                 285             


Arg Leu Gly Asp Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu 
    290                 295                 300                 


Gln Met Cys Lys Thr Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala 
305                 310                 315                 320 


Leu Lys Leu Tyr Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln 
                325                 330                 335     


Phe Ile Arg Lys Val Thr Arg Pro Ala Val Leu Lys Arg His Gly Val 
            340                 345                 350         


Gln Glu Cys Ile Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu 
        355                 360                 365             


Leu Ile Ser Arg Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg 
    370                 375                 380                 


Gln Asp Leu Thr Thr Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn 
385                 390                 395                 400 


Val Asp Glu Gly Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu 
                405                 410                 415     


Ile Tyr Asn Arg Met Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys 
            420                 425                 430         


Gly Pro Phe Gly Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp 
        435                 440                 445             


Gly Cys Leu Leu Trp Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu 
    450                 455                 460                 


Val Leu Leu Met Thr Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln 
465                 470                 475                 480 


Lys Tyr Ile Phe Pro Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln 
                485                 490                 495     


Asn Leu Ile Val Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu 
            500                 505                 510         


Ile Ser Ala Ala Pro Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg 
        515                 520                 525             


Asp Asp Arg Ser Thr Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr 
    530                 535                 540                 


Cys Pro Ser Arg Glu Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala 
545                 550                 555                 560 


Tyr Leu Arg Arg Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu 
                565                 570                 575     


Val Glu Leu Leu Arg Glu Lys Val Gly Leu Phe Ala Glu Met Thr His 
            580                 585                 590         


Phe Gln Ala Glu Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu 
        595                 600                 605             


Pro Arg Gly Leu Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu 
    610                 615                 620                 


Arg Leu Leu Gln Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu 
625                 630                 635                 640 


Leu Val Gly Pro Gly Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala 
                645                 650                 655     


Leu Pro Leu Glu Pro Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr 
            660                 665                 670         


Ala Asn Gly Glu Ala Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg 
        675                 680                 685             


Ala Asp Ser Asp Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg 
    690                 695                 700                 


Ser Pro Gln Glu Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu 
705                 710                 715                 720 


Leu His Gly Leu Gln Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu 
                725                 730                 735     


Ala Arg Phe Pro Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala 
            740                 745                 750         


Asn Ser Arg Asp Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala 
        755                 760                 765             


Pro Glu Lys Gln Ala Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala 
    770                 775                 780                 


Leu Leu Gln Glu Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg 
785                 790                 795                 800 


Ala Thr Glu Ala Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln 
                805                 810                 815     


Ala Arg Ala Leu Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu 
            820                 825                 830         


Ala Ala Leu Gly Gln Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala 
        835                 840                 845             


Arg Arg Pro Val Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala 
    850                 855                 860                 


Leu Tyr Leu Ser Phe Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg 
865                 870                 875                 880 


Leu Asp Leu Pro Val Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp 
                885                 890                 895     


Arg Glu Arg Gln Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser 
            900                 905                 910         


Ser Asp Pro Asp Thr Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser 
        915                 920                 925             


Pro Pro His Ser Pro Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu 
    930                 935                 940                 


Glu Thr Glu Ser Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 
945                 950                 955             


<210>  620
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  620

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Thr Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Asn 
        355                 360                 365             


Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Glu Glu Glu Glu Asp Gly Thr Gly Ser Pro Gln Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210>  621
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  621

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             


Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 


Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
145                 150                 155                 160 


Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     


Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         


Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
        195                 200                 205             


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn Asn 
    210                 215                 220                 


Ser Thr Lys Thr Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
225                 230                 235                 240 


Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                245                 250                 255     


Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys Val 
            260                 265                 270         


Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
        275                 280                 285             


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser 
    290                 295                 300                 


Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
305                 310                 315                 320 


Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
                325                 330                 335     


Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
            340                 345                 350         


Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Thr Asp Val Pro 
        355                 360                 365             


Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
                405                 


<210>  622
<211>  1129
<212>  PRT
<213>  Homo sapiens

<400>  622

Met Arg Ser Ser Ala Ser Arg Leu Ser Ser Phe Ser Ser Arg Asp Ser 
1               5                   10                  15      


Leu Trp Asn Arg Met Pro Asp Gln Ile Ser Val Ser Glu Phe Ile Ala 
            20                  25                  30          


Glu Thr Thr Glu Asp Tyr Asn Ser Pro Thr Thr Ser Ser Phe Thr Thr 
        35                  40                  45              


Arg Leu His Asn Cys Arg Asn Thr Val Thr Leu Leu Glu Glu Ala Leu 
    50                  55                  60                  


Asp Gln Asp Arg Thr Ala Leu Gln Lys Val Lys Lys Ser Val Lys Ala 
65                  70                  75                  80  


Ile Tyr Asn Ser Gly Gln Asp His Val Gln Asn Glu Glu Asn Tyr Ala 
                85                  90                  95      


Gln Val Leu Asp Lys Phe Gly Ser Asn Phe Leu Ser Arg Asp Asn Pro 
            100                 105                 110         


Asp Leu Gly Thr Ala Phe Val Lys Phe Ser Thr Leu Thr Lys Glu Leu 
        115                 120                 125             


Ser Thr Leu Leu Lys Asn Leu Leu Gln Gly Leu Ser His Asn Val Ile 
    130                 135                 140                 


Phe Thr Leu Asp Ser Leu Leu Lys Gly Asp Leu Lys Gly Val Lys Gly 
145                 150                 155                 160 


Asp Leu Lys Lys Pro Phe Asp Lys Ala Trp Lys Asp Tyr Glu Thr Lys 
                165                 170                 175     


Phe Thr Lys Ile Glu Lys Glu Lys Arg Glu His Ala Lys Gln His Gly 
            180                 185                 190         


Met Ile Arg Thr Glu Ile Thr Gly Ala Glu Ile Ala Glu Glu Met Glu 
        195                 200                 205             


Lys Glu Arg Arg Leu Phe Gln Leu Gln Met Cys Glu Tyr Leu Ile Lys 
    210                 215                 220                 


Val Asn Glu Ile Lys Thr Lys Lys Gly Val Asp Leu Leu Gln Asn Leu 
225                 230                 235                 240 


Ile Lys Tyr Tyr His Ala Gln Cys Asn Phe Phe Gln Asp Gly Leu Lys 
                245                 250                 255     


Thr Ala Asp Lys Leu Lys Gln Tyr Ile Glu Lys Leu Ala Ala Asp Leu 
            260                 265                 270         


Tyr Asn Ile Lys Gln Thr Gln Asp Glu Glu Lys Lys Gln Leu Thr Ala 
        275                 280                 285             


Leu Arg Asp Leu Ile Lys Ser Ser Leu Gln Leu Asp Gln Lys Glu Asp 
    290                 295                 300                 


Ser Gln Ser Arg Gln Gly Gly Tyr Ser Met His Gln Leu Gln Gly Asn 
305                 310                 315                 320 


Lys Glu Tyr Gly Ser Glu Lys Lys Gly Tyr Leu Leu Lys Lys Ser Asp 
                325                 330                 335     


Gly Ile Arg Lys Val Trp Gln Arg Arg Lys Cys Ser Val Lys Asn Gly 
            340                 345                 350         


Ile Leu Thr Ile Ser His Ala Thr Ser Asn Arg Gln Pro Ala Lys Leu 
        355                 360                 365             


Asn Leu Leu Thr Cys Gln Val Lys Pro Asn Ala Glu Asp Lys Lys Ser 
    370                 375                 380                 


Phe Asp Leu Ile Ser His Asn Arg Thr Tyr His Phe Gln Ala Glu Asp 
385                 390                 395                 400 


Glu Gln Asp Tyr Val Ala Trp Ile Ser Val Leu Thr Asn Ser Lys Glu 
                405                 410                 415     


Glu Ala Leu Thr Met Ala Phe Arg Gly Glu Gln Ser Ala Gly Glu Asn 
            420                 425                 430         


Ser Leu Glu Asp Leu Thr Lys Ala Ile Ile Glu Asp Val Gln Arg Leu 
        435                 440                 445             


Pro Gly Asn Asp Ile Cys Cys Asp Cys Gly Ser Ser Glu Pro Thr Trp 
    450                 455                 460                 


Leu Ser Thr Asn Leu Gly Ile Leu Thr Cys Ile Glu Cys Ser Gly Ile 
465                 470                 475                 480 


His Arg Glu Met Gly Val His Ile Ser Arg Ile Gln Ser Leu Glu Leu 
                485                 490                 495     


Asp Lys Leu Gly Thr Ser Glu Leu Leu Leu Ala Lys Asn Val Gly Asn 
            500                 505                 510         


Asn Ser Phe Asn Asp Ile Met Glu Ala Asn Leu Pro Ser Pro Ser Pro 
        515                 520                 525             


Lys Pro Thr Pro Ser Ser Asp Met Thr Val Arg Lys Glu Tyr Ile Thr 
    530                 535                 540                 


Ala Lys Tyr Val Asp His Arg Phe Ser Arg Lys Thr Cys Ser Thr Ser 
545                 550                 555                 560 


Ser Ala Lys Leu Asn Glu Leu Leu Glu Ala Ile Lys Ser Arg Asp Leu 
                565                 570                 575     


Leu Ala Leu Ile Gln Val Tyr Ala Glu Gly Val Glu Leu Met Glu Pro 
            580                 585                 590         


Leu Leu Glu Pro Gly Gln Glu Leu Gly Glu Thr Ala Leu His Leu Ala 
        595                 600                 605             


Val Arg Thr Ala Asp Gln Thr Ser Leu His Leu Val Asp Phe Leu Val 
    610                 615                 620                 


Gln Asn Cys Gly Asn Leu Asp Lys Gln Thr Ala Leu Gly Asn Thr Val 
625                 630                 635                 640 


Leu His Tyr Cys Ser Met Tyr Ser Lys Pro Glu Cys Leu Lys Leu Leu 
                645                 650                 655     


Leu Arg Ser Lys Pro Thr Val Asp Ile Val Asn Gln Ala Gly Glu Thr 
            660                 665                 670         


Ala Leu Asp Ile Ala Lys Arg Leu Lys Ala Thr Gln Cys Glu Asp Leu 
        675                 680                 685             


Leu Ser Gln Ala Lys Ser Gly Lys Phe Asn Pro His Val His Val Glu 
    690                 695                 700                 


Tyr Glu Trp Asn Leu Arg Gln Glu Glu Ile Asp Glu Ser Asp Asp Asp 
705                 710                 715                 720 


Leu Asp Asp Lys Pro Ser Pro Ile Lys Lys Glu Arg Ser Pro Arg Pro 
                725                 730                 735     


Gln Ser Phe Cys His Ser Ser Ser Ile Ser Pro Gln Asp Lys Leu Ala 
            740                 745                 750         


Leu Pro Gly Phe Ser Thr Pro Arg Asp Lys Gln Arg Leu Ser Tyr Gly 
        755                 760                 765             


Ala Phe Thr Asn Gln Ile Phe Val Ser Thr Ser Thr Asp Ser Pro Thr 
    770                 775                 780                 


Ser Pro Thr Thr Glu Ala Pro Pro Leu Pro Pro Arg Asn Ala Gly Lys 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Pro Ser Thr Leu Pro Leu Ser Thr Gln Thr Ser 
                805                 810                 815     


Ser Gly Ser Ser Thr Leu Ser Lys Lys Arg Pro Pro Pro Pro Pro Pro 
            820                 825                 830         


Gly His Lys Arg Thr Leu Ser Asp Pro Pro Ser Pro Leu Pro His Gly 
        835                 840                 845             


Pro Pro Asn Lys Gly Ala Val Pro Trp Gly Asn Asp Gly Gly Pro Ser 
    850                 855                 860                 


Ser Ser Ser Lys Thr Thr Asn Lys Phe Glu Gly Leu Ser Gln Gln Ser 
865                 870                 875                 880 


Ser Thr Ser Ser Ala Lys Thr Ala Leu Gly Pro Arg Val Leu Pro Lys 
                885                 890                 895     


Leu Pro Gln Lys Val Ala Leu Arg Lys Thr Asp His Leu Ser Leu Asp 
            900                 905                 910         


Lys Ala Thr Ile Pro Pro Glu Ile Phe Gln Lys Ser Ser Gln Leu Ala 
        915                 920                 925             


Glu Leu Pro Gln Lys Pro Pro Pro Gly Asp Leu Pro Pro Lys Pro Thr 
    930                 935                 940                 


Glu Leu Ala Pro Lys Pro Gln Ile Gly Asp Leu Pro Pro Lys Pro Gly 
945                 950                 955                 960 


Glu Leu Pro Pro Lys Pro Gln Leu Gly Asp Leu Pro Pro Lys Pro Gln 
                965                 970                 975     


Leu Ser Asp Leu Pro Pro Lys Pro Gln Met Lys Asp Leu Pro Pro Lys 
            980                 985                 990         


Pro Gln Leu Gly Asp Leu Leu Ala  Lys Ser Gln Thr Gly  Asp Val Ser 
        995                 1000                 1005             


Pro Lys  Ala Gln Gln Pro Ser  Glu Val Thr Leu Lys  Ser His Pro 
    1010                 1015                 1020             


Leu Asp  Leu Ser Pro Asn Val  Gln Ser Arg Asp Ala  Ile Gln Lys 
    1025                 1030                 1035             


Gln Ala  Ser Glu Asp Ser Asn  Asp Leu Thr Pro Thr  Leu Pro Glu 
    1040                 1045                 1050             


Thr Pro  Val Pro Leu Pro Arg  Lys Ile Asn Thr Gly  Lys Asn Lys 
    1055                 1060                 1065             


Val Arg  Arg Val Lys Thr Ile  Tyr Asp Cys Gln Ala  Asp Asn Asp 
    1070                 1075                 1080             


Asp Glu  Leu Thr Phe Ile Glu  Gly Glu Val Ile Ile  Val Thr Gly 
    1085                 1090                 1095             


Glu Glu  Asp Gln Glu Trp Trp  Ile Gly His Ile Glu  Gly Gln Pro 
    1100                 1105                 1110             


Glu Arg  Lys Gly Val Phe Pro  Val Ser Phe Val His  Ile Leu Ser 
    1115                 1120                 1125             


Asp 
    


<210>  623
<211>  1458
<212>  PRT
<213>  Homo sapiens

<400>  623

Met Val Asn Thr Arg Lys Ser Ser Leu Arg Leu Leu Gly Ser Lys Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Gly Pro Gly Ala Gly Ala Glu Pro Gly Ala Thr 
            20                  25                  30          


Gly Gly Ser Ser His Phe Ile Ser Ser Arg Thr Arg Ser Ser Lys Thr 
        35                  40                  45              


Arg Ala Ala Ser Cys Pro Ala Ala Lys Ala Gly Gly Ser Gly Gly Ala 
    50                  55                  60                  


Gly Val Thr Leu Asp Glu Ala Arg Lys Val Glu Val Asp Gly Ser Leu 
65                  70                  75                  80  


Ser Asp Ser His Val Ser Pro Pro Ala Lys Arg Thr Leu Lys Gln Pro 
                85                  90                  95      


Asp Ser Val Cys Lys Asp Lys Ser Lys Ser Arg Ser Thr Gly Gln Arg 
            100                 105                 110         


Glu Glu Trp Asn Leu Ser Thr Gly Gln Ala Arg Leu Thr Ser Gln Pro 
        115                 120                 125             


Gly Ala Thr Leu Pro Asn Gly His Ser Gly Leu Ser Leu Arg Ser His 
    130                 135                 140                 


Pro Leu Arg Gly Glu Lys Lys Gly Asp Gly Asp Leu Ser Cys Ile Asn 
145                 150                 155                 160 


Gly Asp Met Glu Val Arg Lys Ser Cys Arg Ser Arg Lys Asn Arg Phe 
                165                 170                 175     


Glu Ser Val Asn Gln Ser Leu Leu Phe Asp Gln Leu Val Asn Ser Thr 
            180                 185                 190         


Ala Glu Ala Val Leu Gln Glu Met Asp Asn Ile Asn Ile Arg Arg Asn 
        195                 200                 205             


Arg Arg Ser Gly Glu Val Glu Arg Leu Arg Met Trp Thr Asp Thr Glu 
    210                 215                 220                 


Phe Glu Asn Met Asp Met Tyr Ser Arg Val Lys Arg Arg Arg Lys Ser 
225                 230                 235                 240 


Leu Arg Arg Asn Ser Tyr Gly Ile Gln Asn His His Glu Val Ser Thr 
                245                 250                 255     


Glu Gly Glu Glu Glu Glu Ser Gln Glu Glu Asp Gly Asp Ile Glu Val 
            260                 265                 270         


Glu Glu Ala Glu Gly Glu Glu Asn Asp Arg Pro Tyr Asn Leu Arg Gln 
        275                 280                 285             


Arg Lys Thr Val Asp Arg Tyr Gln Ala Pro Pro Ile Val Pro Ala His 
    290                 295                 300                 


Gln Lys Lys Arg Glu Asn Thr Leu Phe Asp Ile His Arg Ser Pro Ala 
305                 310                 315                 320 


Arg Arg Ser His Ile Arg Arg Lys Lys His Ala Ile His Ser Ser Asp 
                325                 330                 335     


Thr Thr Ser Ser Asp Glu Glu Arg Phe Glu Arg Arg Lys Ser Lys Ser 
            340                 345                 350         


Met Ala Arg Ala Arg Asn Arg Cys Leu Pro Met Asn Phe Arg Ala Glu 
        355                 360                 365             


Asp Leu Ala Ser Gly Ile Leu Arg Glu Arg Val Lys Val Gly Ala Ser 
    370                 375                 380                 


Leu Ala Asp Val Asp Pro Met Asn Ile Asp Lys Ser Val Arg Phe Asp 
385                 390                 395                 400 


Ser Ile Gly Gly Leu Ser His His Ile His Ala Leu Lys Glu Met Val 
                405                 410                 415     


Val Phe Pro Leu Leu Tyr Pro Glu Ile Phe Glu Lys Phe Lys Ile Gln 
            420                 425                 430         


Pro Pro Arg Gly Cys Leu Phe Tyr Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Val Ala Arg Ala Leu Ala Asn Glu Cys Ser Gln Gly Asp Lys Lys 
    450                 455                 460                 


Val Ala Phe Phe Met Arg Lys Gly Ala Asp Cys Leu Ser Lys Trp Val 
465                 470                 475                 480 


Gly Glu Ser Glu Arg Gln Leu Arg Leu Leu Phe Asp Gln Ala Tyr Leu 
                485                 490                 495     


Met Arg Pro Ser Ile Ile Phe Phe Asp Glu Ile Asp Gly Leu Ala Pro 
            500                 505                 510         


Val Arg Ser Ser Arg Gln Asp Gln Ile His Ser Ser Ile Val Ser Thr 
        515                 520                 525             


Leu Leu Ala Leu Met Asp Gly Leu Asp Asn Arg Gly Glu Ile Val Val 
    530                 535                 540                 


Ile Gly Ala Thr Asn Arg Leu Asp Ser Ile Asp Pro Ala Leu Arg Arg 
545                 550                 555                 560 


Pro Gly Arg Phe Asp Arg Glu Phe Leu Phe Asn Leu Pro Asp Gln Lys 
                565                 570                 575     


Ala Arg Lys His Ile Leu Gln Ile His Thr Arg Asp Trp Asn Pro Lys 
            580                 585                 590         


Leu Ser Asp Ala Phe Leu Gly Glu Leu Ala Glu Lys Cys Val Gly Tyr 
        595                 600                 605             


Cys Gly Ala Asp Ile Lys Ala Leu Cys Thr Glu Ala Ala Leu Ile Ala 
    610                 615                 620                 


Leu Arg Arg Arg Tyr Pro Gln Ile Tyr Ala Ser Ser His Lys Leu Gln 
625                 630                 635                 640 


Leu Asp Val Ser Ser Ile Val Leu Ser Ala Gln Asp Phe Tyr His Ala 
                645                 650                 655     


Met Gln Asn Ile Val Pro Ala Ser Gln Arg Ala Val Met Ser Ser Gly 
            660                 665                 670         


His Ala Leu Ser Pro Ile Ile Arg Pro Leu Leu Glu Arg Ser Phe Asn 
        675                 680                 685             


Asn Ile Leu Ala Val Leu Gln Lys Val Phe Pro His Ala Glu Ile Ser 
    690                 695                 700                 


Gln Ser Asp Lys Lys Glu Asp Ile Glu Thr Leu Ile Leu Glu Asp Ser 
705                 710                 715                 720 


Glu Asp Glu Asn Ala Leu Ser Ile Phe Glu Thr Asn Cys His Ser Gly 
                725                 730                 735     


Ser Pro Lys Lys Gln Ser Ser Ser Ala Ala Ile His Lys Pro Tyr Leu 
            740                 745                 750         


His Phe Thr Met Ser Pro Tyr His Gln Pro Thr Ser Tyr Arg Pro Arg 
        755                 760                 765             


Leu Leu Leu Ser Gly Glu Arg Gly Ser Gly Gln Thr Ser His Leu Ala 
    770                 775                 780                 


Pro Ala Leu Leu His Thr Leu Glu Arg Phe Ser Val His Arg Leu Asp 
785                 790                 795                 800 


Leu Pro Ala Leu Tyr Ser Val Ser Ala Lys Thr Pro Glu Glu Ser Cys 
                805                 810                 815     


Ala Gln Ile Phe Arg Glu Ala Arg Arg Thr Val Pro Ser Ile Val Tyr 
            820                 825                 830         


Met Pro His Ile Gly Asp Trp Trp Glu Ala Val Ser Glu Thr Val Arg 
        835                 840                 845             


Ala Thr Phe Leu Thr Leu Leu Gln Asp Ile Pro Ser Phe Ser Pro Ile 
    850                 855                 860                 


Phe Leu Leu Ser Thr Ser Glu Thr Met Tyr Ser Glu Leu Pro Glu Glu 
865                 870                 875                 880 


Val Lys Cys Ile Phe Arg Ile Gln Tyr Glu Glu Val Leu Tyr Ile Gln 
                885                 890                 895     


Arg Pro Ile Glu Glu Asp Arg Arg Lys Phe Phe Gln Glu Leu Ile Leu 
            900                 905                 910         


Asn Gln Ala Ser Met Ala Pro Pro Arg Arg Lys His Ala Ala Leu Cys 
        915                 920                 925             


Ala Met Glu Val Leu Pro Leu Ala Leu Pro Ser Pro Pro Arg Gln Leu 
    930                 935                 940                 


Ser Glu Ser Glu Lys Ser Arg Met Glu Asp Gln Glu Glu Asn Thr Leu 
945                 950                 955                 960 


Arg Glu Leu Arg Leu Phe Leu Arg Asp Val Thr Lys Arg Leu Ala Thr 
                965                 970                 975     


Asp Lys Arg Phe Asn Ile Phe Ser Lys Pro Val Asp Ile Glu Glu Val 
            980                 985                 990         


Ser Asp Tyr Leu Glu Val Ile Lys  Glu Pro Met Asp Leu  Ser Thr Val 
        995                 1000                 1005             


Ile Thr  Lys Ile Asp Lys His  Asn Tyr Leu Thr Ala  Lys Asp Phe 
    1010                 1015                 1020             


Leu Lys  Asp Ile Asp Leu Ile  Cys Ser Asn Ala Leu  Glu Tyr Asn 
    1025                 1030                 1035             


Pro Asp  Lys Asp Pro Gly Asp  Lys Ile Ile Arg His  Arg Ala Cys 
    1040                 1045                 1050             


Thr Leu  Lys Asp Thr Ala His  Ala Ile Ile Ala Ala  Glu Leu Asp 
    1055                 1060                 1065             


Pro Glu  Phe Asn Lys Leu Cys  Glu Glu Ile Lys Glu  Ala Arg Ile 
    1070                 1075                 1080             


Lys Arg  Gly Leu Ser Val Thr  Ser Glu Gln Ile Asn  Pro His Ser 
    1085                 1090                 1095             


Thr Gly  Ala Arg Lys Thr Glu  Thr Arg Val Glu Glu  Ala Phe Arg 
    1100                 1105                 1110             


His Lys  Gln Arg Asn Pro Met  Asp Val Trp His Asn  Ser Ala Asn 
    1115                 1120                 1125             


Lys Cys  Ala Phe Arg Val Arg  Arg Lys Ser Arg Arg  Arg Ser Gln 
    1130                 1135                 1140             


Trp Gly  Lys Gly Ile Ile Lys  Lys Arg Lys Val Asn  Asn Leu Lys 
    1145                 1150                 1155             


Lys Asp  Glu Glu Asp Thr Lys  Phe Ala Asp Tyr Glu  Asn His Thr 
    1160                 1165                 1170             


Glu Asp  Arg Lys Leu Leu Glu  Asn Gly Glu Phe Glu  Val Ser Thr 
    1175                 1180                 1185             


Asp Cys  His Glu Glu Asn Gly  Glu Glu Thr Gly Asp  Leu Ser Met 
    1190                 1195                 1200             


Thr Asn  Asp Glu Ser Ser Cys  Asp Ile Met Asp Leu  Asp Gln Gly 
    1205                 1210                 1215             


Gln Arg  Leu Asn Asn Gly Ala  Gly Thr Lys Glu Asn  Phe Ala Ser 
    1220                 1225                 1230             


Thr Glu  Glu Glu Ser Ser Asn  Glu Ser Leu Leu Val  Asn Ser Ser 
    1235                 1240                 1245             


Ser Ser  Leu Asn Pro Glu Gln  Thr Ser Arg Lys Glu  Thr Phe Leu 
    1250                 1255                 1260             


Lys Gly  Asn Cys Leu Asn Gly  Glu Ala Ser Thr Asp  Ser Phe Glu 
    1265                 1270                 1275             


Gly Ile  Pro Val Leu Glu Cys  Gln Asn Gly Lys Leu  Glu Val Val 
    1280                 1285                 1290             


Ser Phe  Cys Asp Ser Gly Asp  Lys Cys Ser Ser Glu  Gln Lys Ile 
    1295                 1300                 1305             


Leu Leu  Glu Asp Gln Ser Lys  Glu Lys Pro Glu Thr  Ser Thr Glu 
    1310                 1315                 1320             


Asn His  Gly Asp Asp Leu Glu  Lys Leu Glu Ala Leu  Glu Cys Ser 
    1325                 1330                 1335             


Asn Asn  Glu Lys Leu Glu Pro  Gly Ser Asp Val Glu  Val Lys Asp 
    1340                 1345                 1350             


Ala Glu  Leu Asp Lys Glu Gly  Ala Ser Lys Val Lys  Lys Tyr Arg 
    1355                 1360                 1365             


Lys Leu  Ile Leu Glu Gln Ala  Lys Thr Thr Ser Leu  Glu Leu Val 
    1370                 1375                 1380             


Pro Glu  Glu Pro Ser Glu Pro  Val Pro Pro Leu Ile  Val Asp Arg 
    1385                 1390                 1395             


Glu Arg  Leu Lys Lys Leu Leu  Asp Leu Leu Val Asp  Lys Ser Asn 
    1400                 1405                 1410             


Asn Leu  Ala Val Asp Gln Leu  Glu Arg Leu Tyr Ser  Leu Leu Ser 
    1415                 1420                 1425             


Gln Cys  Ile Tyr Arg His Arg  Lys Asp Tyr Asp Lys  Ser Gln Leu 
    1430                 1435                 1440             


Val Glu  Glu Met Glu Arg Thr  Val His Met Phe Glu  Thr Phe Leu 
    1445                 1450                 1455             


<210>  624
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  624

Met Ala Ser Pro Asp Arg Ser Lys Arg Lys Ile Leu Lys Ala Lys Lys 
1               5                   10                  15      


Thr Met Pro Leu Ser Cys Arg Lys Gln Val Glu Met Leu Asn Lys Ser 
            20                  25                  30          


Arg Asn Val Glu Ala Leu Lys Thr Ala Ile Gly Ser Asn Val Pro Ser 
        35                  40                  45              


Gly Asn Gln Ser Phe Ser Pro Ser Val Ile Thr Arg Thr Thr Glu Ile 
    50                  55                  60                  


Thr Lys Cys Ser Pro Ser Glu Asn Gly Ala Ser Ser Leu Asp Ser Asn 
65                  70                  75                  80  


Lys Asn Ser Ile Ser Glu Lys Ser Lys Val Phe Ser Gln Asn Cys Ile 
                85                  90                  95      


Lys Pro Val Glu Glu Ile Val His Ser Glu Thr Lys Leu Glu Gln Val 
            100                 105                 110         


Val Cys Ser Tyr Gln Lys Pro Ser Arg Thr Thr Glu Ser Pro Ser Arg 
        115                 120                 125             


Val Phe Thr Glu Glu Ala Lys Asp Ser Leu Asn Thr Ser Glu Asn Asp 
    130                 135                 140                 


Ser Glu His Gln Thr Asn Val Thr Arg Ser Leu Phe Glu His Glu Gly 
145                 150                 155                 160 


Ala Cys Ser Leu Lys Ser Ser Cys Cys Pro Pro Ser Val Leu Ser Gly 
                165                 170                 175     


Val Val Gln Met Pro Glu Ser Thr Val Thr Ser Thr Val Gly Asp Lys 
            180                 185                 190         


Lys Thr Asp Gln Met Val Phe His Leu Glu Thr Asn Ser Asn Ser Glu 
        195                 200                 205             


Ser His Asp Lys Arg Gln Ser Asp Asn Ile Leu Cys Ser Glu Asp Ser 
    210                 215                 220                 


Gly Phe Val Pro Val Glu Lys Thr Pro Asn Leu Val Asn Ser Val Thr 
225                 230                 235                 240 


Ser Asn Asn Cys Ala Asp Asp Ile Leu Lys Thr Asp Glu Cys Ser Arg 
                245                 250                 255     


Thr Ser Ile Ser Asn Cys Glu Ser Ala Asp Ser Thr Trp Gln Ser Ser 
            260                 265                 270         


Leu Asp Thr Asn Asn Asn Ser His Tyr Gln Lys Lys Arg Met Phe Ser 
        275                 280                 285             


Glu Asn Glu Glu Asn Val Lys Arg Met Lys Thr Ser Glu Gln Ile Asn 
    290                 295                 300                 


Glu Asn Ile Cys Val Ser Leu Glu Arg Gln Thr Ala Phe Leu Glu Gln 
305                 310                 315                 320 


Val Arg His Leu Ile Gln Gln Glu Ile Tyr Ser Ile Asn Tyr Glu Leu 
                325                 330                 335     


Phe Asp Lys Lys Leu Lys Glu Leu Asn Gln Arg Ile Gly Lys Thr Glu 
            340                 345                 350         


Cys Arg Asn Lys His Glu Gly Ile Ala Asp Lys Leu Leu Ala Lys Ile 
        355                 360                 365             


Ala Lys Leu Gln Arg Arg Ile Lys Thr Val Leu Leu Phe Gln Arg Asn 
    370                 375                 380                 


Cys Leu Lys Pro Asn Met Leu Ser Ser Asn Gly Ala Ser Lys Val Ala 
385                 390                 395                 400 


Asn Ser Glu Ala Met Ile Leu Asp Lys Asn Leu Glu Ser Val Asn Ser 
                405                 410                 415     


Pro Ile Glu Lys Ser Ser Val Asn Tyr Glu Pro Ser Asn Pro Ser Glu 
            420                 425                 430         


Lys Gly Ser Lys Lys Ile Asn Leu Ser Ser Asp Gln Asn Lys Ser Val 
        435                 440                 445             


Ser Glu Ser Asn Asn Asp Asp Val Met Leu Ile Ser Val Glu Ser Pro 
    450                 455                 460                 


Asn Leu Thr Thr Pro Ile Thr Ser Asn Pro Thr Asp Thr Arg Lys Ile 
465                 470                 475                 480 


Thr Ser Gly Asn Ser Ser Asn Ser Pro Asn Ala Glu Val Met Ala Val 
                485                 490                 495     


Gln Lys Lys Leu Asp Ser Ile Ile Asp Leu Thr Lys Glu Gly Leu Ser 
            500                 505                 510         


Asn Cys Asn Thr Glu Ser Pro Val Ser Pro Leu Glu Ser His Ser Lys 
        515                 520                 525             


Ala Ala Ser Asn Ser Lys Glu Thr Thr Pro Leu Ala Gln Asn Ala Val 
    530                 535                 540                 


Gln Val Pro Glu Ser Phe Glu His Leu Pro Pro Leu Pro Glu Pro Pro 
545                 550                 555                 560 


Ala Pro Leu Pro Glu Leu Val Asp Lys Thr Arg Asp Thr Leu Pro Pro 
                565                 570                 575     


Gln Lys Pro Glu Leu Lys Val Lys Arg Val Phe Arg Pro Asn Gly Ile 
            580                 585                 590         


Ala Leu Thr Trp Asn Ile Thr Lys Ile Asn Pro Lys Cys Ala Pro Val 
        595                 600                 605             


Glu Ser Tyr His Leu Phe Leu Cys His Glu Asn Ser Asn Asn Lys Leu 
    610                 615                 620                 


Ile Trp Lys Lys Ile Gly Glu Ile Lys Ala Leu Pro Leu Pro Met Ala 
625                 630                 635                 640 


Cys Thr Leu Ser Gln Phe Leu Ala Ser Asn Arg Tyr Tyr Phe Thr Val 
                645                 650                 655     


Gln Ser Lys Asp Ile Phe Gly Arg Tyr Gly Pro Phe Cys Asp Ile Lys 
            660                 665                 670         


Ser Ile Pro Gly Phe Ser Glu Asn Leu Thr 
        675                 680         


<210>  625
<211>  3056
<212>  PRT
<213>  Homo sapiens

<400>  625

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  626
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
1               5                   10                  15      


Leu Pro Val Pro Thr Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
            20                  25                  30          


Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Thr Tyr Lys 
        35                  40                  45              


Thr Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
    50                  55                  60                  


Phe Pro Arg Tyr Ala Glu Ile Val His Leu Thr Leu Pro Asp Gly Thr 
65                  70                  75                  80  


Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                85                  90                  95      


Gln Val Phe Glu Gly Thr Ser Gly Ile Asp Ala Lys Lys Thr Ser Cys 
            100                 105                 110         


Glu Phe Thr Gly Asp Ile Leu Arg Thr Pro Val Ser Glu Asp Met Leu 
        115                 120                 125             


Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
    130                 135                 140                 


Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
145                 150                 155                 160 


Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Thr Gly Ile Ser Ala 
                165                 170                 175     


Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
            180                 185                 190         


Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
        195                 200                 205             


Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
    210                 215                 220                 


Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Thr 
225                 230                 235                 240 


Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                245                 250                 255     


Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile 
            260                 265                 270         


Ile Thr Pro Arg Leu Ala Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln 
        275                 280                 285             


Cys Glu Lys His Val Leu Val Ile Leu Thr Asp Met Ser Ser Tyr Ala 
    290                 295                 300                 


Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
305                 310                 315                 320 


Arg Gly Phe Pro Gly Tyr Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu 
                325                 330                 335     


Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Thr Gln Ile Pro 
            340                 345                 350         


Ile Leu Thr Met Pro Asn Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
        355                 360                 365             


Thr Gly Tyr Ile Thr Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
    370                 375                 380                 


Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
385                 390                 395                 400 


Leu Met Lys Ser Ala Ile Gly Glu Gly Met Thr Arg Lys Asp His Ala 
                405                 410                 415     


Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
            420                 425                 430         


Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Thr Ser Asp Asp 
        435                 440                 445             


Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile Ala 
    450                 455                 460                 


Gln Gly Pro Tyr Glu Asn Arg Thr Val Phe Glu Thr Leu Asp Ile Gly 
465                 470                 475                 480 


Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                485                 490                 495     


Gln Ser Thr Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
            500                 505                 510     


<210>  627
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  627

Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Thr Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Thr Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Thr Leu Pro Glu Glu Val Thr 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Thr Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Thr Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Thr Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Thr Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Thr Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Thr Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu Pro Ser Leu Cys 
    210                 215                 220                 


Pro Lys Tyr Arg Lys Phe Gln Lys Ala Phe Gly Thr Asp Arg Val Arg 
225                 230                 235                 240 


Thr Gly Glu Ser Ser Val Lys Asp Ile His Ala Ser Val Gln Pro Asn 
                245                 250                 255     


Glu Arg Ser Glu Asn Glu Cys Leu Gly Gly Val Pro Glu Cys Arg Asp 
            260                 265                 270         


Leu Gln Val Met Leu Lys Cys Asp Glu Ser Lys Leu Ala Met Glu Pro 
        275                 280                 285             


Glu Glu Thr Lys Lys Asp Pro Ala Ser Gln Cys Pro Thr Glu Lys Ser 
    290                 295                 300                 


Glu Val Thr Pro Phe Pro His Asn Ser Ser Ile Asp Pro His Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Leu Leu His Thr Tyr Asp Gln Tyr Gly Asp Leu Asn 
                325                 330                 335     


Phe Ala Gly Met Gln Asn Thr Thr Val Leu Thr Glu Lys Pro Leu Ser 
            340                 345                 350         


Gly Thr Asp Val Gln Glu Lys Thr Phe Gly Glu Ser Gln Asp Leu Pro 
        355                 360                 365             


Leu Lys Ser Asp Leu Gly Thr Arg Glu Asp Ser Ser Val Ala Ser Ser 
    370                 375                 380                 


Asp Arg Ser Ser Val Glu Arg Glu Val Ala Glu His Leu Ala Lys Gly 
385                 390                 395                 400 


Phe Trp Ser Asp Ile Cys Ser Thr Asp Thr Pro Cys Gln Met Gln Leu 
                405                 410                 415     


Ser Pro Ala Val Ala Lys Asp Gly Ser Glu Gln Ile Ser Gln Lys Arg 
            420                 425                 430         


Ser Glu Cys Pro Trp Leu Gly Ile Arg Ile Ser Glu Ser Pro Glu Pro 
        435                 440                 445             


Gly Gln Arg Thr Phe Thr Thr Leu Ser Ser Val Asn Cys Pro Phe Ile 
    450                 455                 460                 


Ser Thr Leu Ser Thr Glu Gly Cys Ser Ser Asn Leu Glu Ile Gly Asn 
465                 470                 475                 480 


Asp Asp Tyr Val Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys 
                485                 490                 495     


Val Ile Ser Leu Gly Asp Asp Ser Glu Thr Asp Thr Glu Gly Asp Ser 
            500                 505                 510         


Glu Ser Cys Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe 
        515                 520                 525             


Asn Ala Gln Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu 
    530                 535                 540                 


Leu Lys Met His Lys Leu Thr Pro Glu Gln Leu Asp Cys Ile His Asp 
545                 550                 555                 560 


Ile Arg Arg Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys 
                565                 570                 575     


Arg Lys Leu Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu 
            580                 585                 590         


Gln Ser Glu Lys Glu Ser Leu Leu Lys Glu Arg Asp His Ile Leu Ser 
        595                 600                 605             


Thr Leu Gly Glu Thr Lys Gln Asn Leu Thr Gly Leu Cys Gln Lys Val 
    610                 615                 620                 


Cys Lys Glu Ala Ala Leu Ser Gln Glu Gln Ile Gln Ile Leu Ala Lys 
625                 630                 635                 640 


Tyr Ser Ala Ala Asp Cys Pro Leu Ser Phe Leu Ile Ser Glu Lys Asp 
                645                 650                 655     


Lys Ser Thr Pro Asp Gly Glu Leu Ala Leu Pro Ser Ile Phe Ser Leu 
            660                 665                 670         


Ser Asp Arg Pro Pro Ala Val Leu Pro Pro Cys Ala Arg Gly Asn Ser 
        675                 680                 685             


Glu Pro Gly Tyr Ala Arg Gly Gln Glu Ser Gln Gln Met Ser Thr Ala 
    690                 695                 700                 


Thr Ser Glu Gln Ala Gly Pro Ala Glu Gln Cys Arg Gln Ser Gly Gly 
705                 710                 715                 720 


Ile Ser Asp Phe Cys Gln Gln Met Thr Asp Lys Cys Thr Thr Asp Glu 
                725                 730                 735     


<210>  628
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Thr 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Thr Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Thr Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Thr Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Thr Gln Thr Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Thr Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Thr Leu Ile Thr Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Thr Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Thr Asn Cys Arg Thr Ala Glu Lys Met Ala Leu Thr Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Thr Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Thr Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Thr Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Thr Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Thr Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Ile Pro Gln Gly His Leu His 
        355                 360                 365             


Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile Thr Gln Asp Ser 
    370                 375                 380                 


Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp Gly Gln Val Leu 
385                 390                 395                 400 


Gln Gly Ala Gln Leu Ile Ala Val Ala Ser Ser Asp Pro Ala Ala Ala 
                405                 410                 415     


Gly Val Asp Gly Ser Pro Leu Gln Gly Ser Asp Ile Gln Val Gln Tyr 
            420                 425                 430         


Val Gln Leu Ala Pro Val Ser Asp His Thr Ala Gly Ala Gln Thr Ala 
        435                 440                 445             


Glu Ala Leu Gln Pro Thr Leu Gln Pro Glu Met Gln Leu Glu His Gly 
    450                 455                 460                 


Ala Ile Gln Ile Gln 
465                 


<210>  629
<211>  2168
<212>  PRT
<213>  Homo sapiens

<400>  629

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Thr Ala Gly Asp Gln Pro Phe Asn Leu Ser Thr 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Thr Leu Gly 
                85                  90                  95      


Thr Pro Thr Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Gly 
            100                 105                 110         


Ala Glu Trp Trp Arg Thr Thr Asp Ala His Thr Arg Thr Gly Ala Thr 
        115                 120                 125             


Phe Phe Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala 
    130                 135                 140                 


Gln Asn His Asp Ser Ser Ser Phe His Ser Arg Thr Ser Gly Lys Ser 
145                 150                 155                 160 


Asn Arg Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser 
                165                 170                 175     


Asn Thr Ser Ser Val Ile Gly Ile Asn Thr Ser Val Leu Ser Thr Thr 
            180                 185                 190         


Ala Ser Ser Ser Met Gly Gln Thr Lys Ser Thr Ser Ser Gly Gly Gly 
        195                 200                 205             


Asn Arg Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala 
    210                 215                 220                 


Arg Val Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu 
225                 230                 235                 240 


Ser Ser Ser Asn Ser Asp Ser Asp Ser Gly Thr Ser Ser Asp Thr Ser 
                245                 250                 255     


Ser Glu Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu 
            260                 265                 270         


Glu Glu Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp 
        275                 280                 285             


Ser Glu Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His 
    290                 295                 300                 


Gly Ile Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Thr Glu Lys Ala 
305                 310                 315                 320 


Gln Glu Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln 
                325                 330                 335     


Thr His Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln 
            340                 345                 350         


Gln Leu Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val 
        355                 360                 365             


Asn Lys His Thr Ser Val Ile Gln Ser Thr Gly Leu Val Ser Asn Val 
    370                 375                 380                 


Lys Pro Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Thr Tyr Met Lys 
385                 390                 395                 400 


Leu Ile Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Thr 
                405                 410                 415     


Ser Glu Glu Ser Ser Leu Leu Thr Ser Glu Leu Arg Ser Lys Arg Glu 
            420                 425                 430         


Gln Tyr Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser 
        435                 440                 445             


Lys Ser Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Thr 
    450                 455                 460                 


Ser Ser Ser Pro Ala His Pro Lys Gln Thr Leu Glu Asn Asn His Pro 
465                 470                 475                 480 


Asn Pro Phe Leu Thr Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly 
                485                 490                 495     


Val Ile Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Thr Thr Lys 
            500                 505                 510         


Thr Lys Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser 
        515                 520                 525             


Thr Pro Phe Ser Ser Pro Val Asn Leu Ser Thr Ser Gly Arg Arg Thr 
    530                 535                 540                 


Pro Gly Asn Gln Thr Pro Val Met Pro Ser Ala Ser Pro Ile Leu His 
545                 550                 555                 560 


Ser Gln Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys 
                565                 570                 575     


Thr Gln His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg 
            580                 585                 590         


Gly Thr Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn 
        595                 600                 605             


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu 
    610                 615                 620                 


Asp Asp Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu 
625                 630                 635                 640 


Ser Asp Thr Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln 
                645                 650                 655     


Asp Glu Ser Asp Ser Asp Thr Glu Gly Glu Lys Thr Ser Met Lys Leu 
            660                 665                 670         


Asn Lys Thr Thr Ser Ser Val Lys Ser Pro Ser Met Ser Leu Thr Gly 
        675                 680                 685             


His Ser Thr Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala 
    690                 695                 700                 


Pro Ala Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Thr 
705                 710                 715                 720 


Ser Ser Ser Thr Leu Thr Ser Ser Pro His Ser Gly Thr Ser Lys Arg 
                725                 730                 735     


Arg Arg Val Thr Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly 
            740                 745                 750         


Trp Gln Arg Glu Thr Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly 
        755                 760                 765             


Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro 
    770                 775                 780                 


Glu Val Ile Lys Tyr Leu Ser Arg Asn Gly Ile Met Asp Ile Ser Arg 
785                 790                 795                 800 


Asp Asn Phe Ser Phe Ser Ala Lys Ile Arg Val Gly Asp Phe Tyr Glu 
                805                 810                 815     


Ala Arg Asp Gly Pro Gln Gly Met Gln Trp Cys Leu Leu Lys Glu Glu 
            820                 825                 830         


Asp Val Ile Pro Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro 
        835                 840                 845             


Pro Asn Pro Asp Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg 
    850                 855                 860                 


Arg Lys Gly Arg Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn 
865                 870                 875                 880 


Ala Asp Ala Lys Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg 
                885                 890                 895     


Gln Ala Ala Gln Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln 
            900                 905                 910         


Ala Arg Val Ala Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala 
        915                 920                 925             


Glu Glu Lys Arg Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln 
    930                 935                 940                 


Glu Lys Ile Lys Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg 
945                 950                 955                 960 


Ala Gln Gln Ile Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala 
                965                 970                 975     


Asn Ala Lys Leu Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met 
            980                 985                 990         


Arg Arg Gln Gln Ala Val Leu Leu  Lys His Gln Glu Arg  Glu Arg Arg 
        995                 1000                 1005             


Arg Gln  His Met Met Leu Met  Lys Ala Met Glu Ala  Arg Lys Lys 
    1010                 1015                 1020             


Ala Glu  Glu Lys Glu Arg Leu  Lys Gln Glu Lys Arg  Asp Glu Lys 
    1025                 1030                 1035             


Arg Leu  Asn Lys Glu Arg Lys  Leu Glu Gln Arg Arg  Leu Glu Leu 
    1040                 1045                 1050             


Glu Met  Ala Lys Glu Leu Lys  Lys Pro Asn Glu Asp  Met Cys Leu 
    1055                 1060                 1065             


Ala Asp  Gln Lys Pro Leu Pro  Glu Leu Pro Arg Ile  Pro Gly Leu 
    1070                 1075                 1080             


Val Leu  Ser Gly Ser Thr Phe  Ser Asp Cys Leu Met  Val Val Gln 
    1085                 1090                 1095             


Phe Leu  Arg Asn Phe Gly Lys  Val Leu Gly Phe Asp  Val Asn Ile 
    1100                 1105                 1110             


Asp Val  Pro Asn Leu Ser Val  Leu Gln Glu Gly Leu  Leu Asn Ile 
    1115                 1120                 1125             


Gly Asp  Ser Met Gly Glu Val  Gln Asp Leu Leu Val  Arg Leu Leu 
    1130                 1135                 1140             


Ser Ala  Ala Val Cys Asp Pro  Gly Leu Ile Thr Gly  Tyr Lys Ala 
    1145                 1150                 1155             


Lys Thr  Ala Leu Gly Glu His  Leu Leu Asn Val Gly  Val Asn Arg 
    1160                 1165                 1170             


Asp Asn  Val Ser Glu Ile Leu  Gln Ile Phe Met Glu  Ala His Cys 
    1175                 1180                 1185             


Gly Gln  Thr Glu Leu Thr Glu  Ser Leu Lys Thr Lys  Ala Phe Gln 
    1190                 1195                 1200             


Ala His  Thr Pro Ala Gln Lys  Ala Ser Val Leu Ala  Phe Leu Ile 
    1205                 1210                 1215             


Asn Glu  Leu Ala Cys Ser Lys  Ser Val Val Ser Glu  Ile Asp Lys 
    1220                 1225                 1230             


Asn Ile  Asp Tyr Met Ser Asn  Leu Arg Arg Asp Lys  Trp Val Val 
    1235                 1240                 1245             


Glu Gly  Lys Leu Arg Lys Leu  Arg Ile Ile His Ala  Lys Lys Thr 
    1250                 1255                 1260             


Gly Lys  Arg Asp Thr Ser Gly  Gly Ile Asp Leu Gly  Glu Glu Gln 
    1265                 1270                 1275             


His Pro  Leu Gly Thr Pro Thr  Pro Gly Arg Lys Arg  Arg Arg Lys 
    1280                 1285                 1290             


Gly Gly  Asp Ser Asp Tyr Asp  Asp Asp Asp Asp Asp  Asp Ser Asp 
    1295                 1300                 1305             


Asp Gln  Gly Asp Glu Asp Asp  Glu Asp Glu Glu Asp  Lys Glu Asp 
    1310                 1315                 1320             


Lys Lys  Gly Lys Lys Thr Asp  Ile Cys Glu Asp Glu  Asp Glu Gly 
    1325                 1330                 1335             


Asp Gln  Ala Ala Ser Val Glu  Glu Leu Glu Lys Gln  Ile Glu Lys 
    1340                 1345                 1350             


Leu Ser  Lys Gln Gln Ser Gln  Tyr Arg Arg Lys Leu  Phe Asp Ala 
    1355                 1360                 1365             


Ser His  Ser Leu Arg Ser Val  Met Phe Gly Gln Asp  Arg Tyr Arg 
    1370                 1375                 1380             


Arg Arg  Tyr Trp Ile Leu Pro  Gln Cys Gly Gly Ile  Phe Val Glu 
    1385                 1390                 1395             


Gly Met  Glu Ser Gly Glu Gly  Leu Glu Glu Ile Ala  Lys Glu Arg 
    1400                 1405                 1410             


Glu Lys  Leu Lys Lys Ala Glu  Ser Val Gln Ile Lys  Glu Glu Met 
    1415                 1420                 1425             


Phe Glu  Thr Ser Gly Asp Ser  Leu Asn Cys Ser Asn  Thr Asp His 
    1430                 1435                 1440             


Cys Glu  Gln Lys Glu Asp Leu  Lys Glu Lys Asp Asn  Thr Asn Leu 
    1445                 1450                 1455             


Phe Leu  Gln Lys Pro Gly Ser  Phe Ser Lys Leu Ser  Lys Leu Leu 
    1460                 1465                 1470             


Glu Val  Ala Lys Met Pro Pro  Glu Ser Glu Val Met  Thr Pro Lys 
    1475                 1480                 1485             


Pro Asn  Ala Gly Ala Asn Gly  Cys Thr Leu Ser Tyr  Gln Asn Ser 
    1490                 1495                 1500             


Gly Lys  His Ser Leu Gly Ser  Val Gln Ser Thr Ala  Thr Gln Ser 
    1505                 1510                 1515             


Asn Val  Glu Lys Ala Asp Ser  Asn Asn Leu Phe Asn  Thr Gly Ser 
    1520                 1525                 1530             


Ser Gly  Pro Gly Lys Phe Tyr  Ser Pro Leu Pro Asn  Asp Gln Leu 
    1535                 1540                 1545             


Leu Lys  Thr Leu Thr Glu Lys  Asn Arg Gln Trp Phe  Ser Leu Leu 
    1550                 1555                 1560             


Pro Arg  Thr Pro Cys Asp Asp  Thr Ser Leu Thr His  Ala Asp Met 
    1565                 1570                 1575             


Ser Thr  Ala Ser Leu Val Thr  Pro Gln Ser Gln Pro  Pro Ser Lys 
    1580                 1585                 1590             


Ser Pro  Ser Pro Thr Pro Ala  Pro Leu Gly Ser Ser  Ala Gln Asn 
    1595                 1600                 1605             


Pro Val  Gly Leu Asn Pro Phe  Ala Leu Ser Pro Leu  Gln Val Lys 
    1610                 1615                 1620             


Gly Gly  Val Ser Met Met Gly  Leu Gln Phe Cys Gly  Trp Pro Thr 
    1625                 1630                 1635             


Gly Val  Val Thr Ser Asn Ile  Pro Phe Thr Ser Ser  Val Pro Ser 
    1640                 1645                 1650             


Leu Gly  Ser Gly Leu Gly Leu  Ser Glu Gly Asn Gly  Asn Ser Phe 
    1655                 1660                 1665             


Leu Thr  Ser Asn Val Ala Ser  Ser Lys Ser Glu Ser  Pro Val Pro 
    1670                 1675                 1680             


Gln Asn  Glu Lys Ala Thr Ser  Ala Gln Pro Ala Ala  Val Glu Val 
    1685                 1690                 1695             


Ala Lys  Pro Val Asp Phe Pro  Ser Pro Lys Pro Ile  Pro Glu Glu 
    1700                 1705                 1710             


Met Gln  Phe Gly Trp Trp Arg  Ile Ile Asp Pro Glu  Asp Leu Lys 
    1715                 1720                 1725             


Ala Leu  Leu Lys Val Leu His  Leu Arg Gly Ile Arg  Glu Lys Ala 
    1730                 1735                 1740             


Leu Gln  Lys Gln Ile Gln Lys  His Leu Asp Tyr Ile  Thr Gln Ala 
    1745                 1750                 1755             


Cys Leu  Lys Asn Lys Asp Val  Ala Ile Ile Glu Leu  Asn Glu Asn 
    1760                 1765                 1770             


Glu Glu  Asn Gln Val Thr Arg  Asp Ile Val Glu Asn  Trp Ser Val 
    1775                 1780                 1785             


Glu Glu  Gln Ala Met Glu Met  Asp Leu Ser Val Leu  Gln Gln Val 
    1790                 1795                 1800             


Glu Asp  Leu Glu Arg Arg Val  Ala Ser Ala Ser Leu  Gln Val Lys 
    1805                 1810                 1815             


Gly Trp  Met Cys Pro Glu Pro  Ala Ser Glu Arg Glu  Asp Leu Val 
    1820                 1825                 1830             


Tyr Phe  Glu His Lys Ser Phe  Thr Lys Leu Cys Lys  Glu His Asp 
    1835                 1840                 1845             


Gly Glu  Phe Thr Gly Glu Asp  Glu Ser Ser Ala His  Ala Leu Glu 
    1850                 1855                 1860             


Arg Lys  Ser Asp Asn Pro Leu  Asp Ile Ala Val Thr  Arg Leu Ala 
    1865                 1870                 1875             


Asp Leu  Glu Arg Asn Ile Glu  Arg Arg Ile Glu Glu  Asp Ile Ala 
    1880                 1885                 1890             


Pro Gly  Leu Arg Val Trp Arg  Arg Ala Leu Ser Glu  Ala Arg Ser 
    1895                 1900                 1905             


Ala Ala  Gln Val Ala Leu Cys  Ile Gln Gln Leu Gln  Lys Ser Ile 
    1910                 1915                 1920             


Ala Trp  Glu Lys Ser Ile Met  Lys Val Tyr Cys Gln  Ile Cys Arg 
    1925                 1930                 1935             


Lys Gly  Asp Asn Glu Glu Leu  Leu Leu Leu Cys Asp  Gly Cys Asp 
    1940                 1945                 1950             


Lys Gly  Cys His Thr Tyr Cys  His Arg Pro Lys Ile  Thr Thr Ile 
    1955                 1960                 1965             


Pro Asp  Gly Asp Trp Phe Cys  Pro Ala Cys Ile Ala  Lys Ala Ser 
    1970                 1975                 1980             


Gly Gln  Thr Leu Lys Ile Lys  Lys Leu His Val Lys  Gly Lys Lys 
    1985                 1990                 1995             


Thr Asn  Glu Ser Lys Lys Gly  Lys Lys Val Thr Leu  Thr Gly Asp 
    2000                 2005                 2010             


Thr Glu  Asp Glu Asp Ser Ala  Ser Thr Ser Ser Ser  Leu Lys Arg 
    2015                 2020                 2025             


Gly Asn  Lys Asp Leu Lys Lys  Arg Lys Met Glu Glu  Asn Thr Ser 
    2030                 2035                 2040             


Ile Asn  Leu Ser Lys Gln Glu  Ser Phe Thr Ser Val  Lys Lys Pro 
    2045                 2050                 2055             


Lys Arg  Asp Asp Ser Lys Asp  Leu Ala Leu Cys Ser  Met Ile Leu 
    2060                 2065                 2070             


Thr Glu  Met Glu Thr His Glu  Asp Ala Trp Pro Phe  Leu Leu Pro 
    2075                 2080                 2085             


Val Asn  Leu Lys Leu Val Pro  Gly Tyr Lys Lys Val  Ile Lys Lys 
    2090                 2095                 2100             


Pro Met  Asp Phe Ser Thr Ile  Arg Glu Lys Leu Ser  Ser Gly Gln 
    2105                 2110                 2115             


Tyr Pro  Asn Leu Glu Thr Phe  Ala Leu Asp Val Arg  Leu Val Phe 
    2120                 2125                 2130             


Asp Asn  Cys Glu Thr Phe Asn  Glu Asp Asp Ser Asp  Ile Gly Arg 
    2135                 2140                 2145             


Ala Gly  His Asn Met Arg Lys  Tyr Phe Glu Lys Lys  Trp Thr Asp 
    2150                 2155                 2160             


Thr Phe  Lys Val Ser 
    2165             


<210>  630
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  631
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  631

Met Glu Ser Lys Glu Glu Leu Ala Ala Asn Asn Leu Asn Gly Glu Asn 
1               5                   10                  15      


Ala Gln Gln Glu Asn Glu Gly Gly Glu Gln Ala Pro Thr Gln Asn Glu 
            20                  25                  30          


Glu Glu Ser Arg His Leu Gly Gly Gly Glu Gly Gln Lys Pro Gly Gly 
        35                  40                  45              


Asn Ile Arg Arg Gly Arg Val Arg Arg Leu Val Pro Asn Phe Arg Trp 
    50                  55                  60                  


Ala Ile Pro Asn Arg His Ile Glu His Asn Glu Ala Arg Asp Asp Val 
65                  70                  75                  80  


Glu Arg Phe Val Gly Gln Met Met Glu Ile Lys Arg Lys Thr Arg Glu 
                85                  90                  95      


Gln Gln Met Arg His Tyr Met Arg Phe Gln Thr Pro Glu Pro Asp Asn 
            100                 105                 110         


His Tyr Asp Phe Cys Leu Ile Pro 
        115                 120 


<210>  632
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys 
            20                  25                  30          


Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg 
        35                  40                  45              


His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr 
    50                  55                  60                  


Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg 
65                  70                  75                  80  


Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile 
                85                  90                  95      


Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu 
            100                 105                 110         


Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile 
        115                 120                 125             


Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys 
    130                 135                 140                 


Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys 
145                 150                 155                 160 


Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile 
                165                 170                 175     


Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly 
            180                 185                 190         


Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn 
        195                 200                 205             


Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr 
    210                 215                 220                 


Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly 
225                 230                 235                 240 


Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu 
                245                 250                 255     


Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala 
            260                 265                 270         


Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg 
        275                 280                 285             


Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His 
    290                 295                 300                 


Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys 
305                 310                 315                 320 


Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala 
                325                 330                 335     


Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln 
            340                 345                 350         


Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile 
        355                 360                 365             


Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro 
    370                 375                 380                 


Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala 
385                 390                 395                 400 


Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly 
                405                 410                 415     


Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro 
            420                 425                 430         


Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu 
        435                 440                 445             


Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln 
    450                 455                 460                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu 
                485                 490                 495     


Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln 
            500                 505                 510         


Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro 
        515                 520                 525             


Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe 
    530                 535                 540                 


Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala 
545                 550                 555                 560 


Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val 
                565                 570                 575     


Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser 
            580                 585                 590         


Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn 
        595                 600                 605             


Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp 
    610                 615                 620                 


Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu 
625                 630                 635                 640 


Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Ser Lys Gly His Leu Lys 
                645                 650                 655     


Ala Tyr Phe Ala Ser Gln 
            660         


<210>  633
<211>  1058
<212>  PRT
<213>  Homo sapiens

<400>  633

Met Arg Arg Lys Gly Arg Cys His Arg Gly Ser Ala Ala Arg His Pro 
1               5                   10                  15      


Ser Ser Pro Cys Ser Val Lys His Ser Pro Thr Arg Glu Thr Leu Thr 
            20                  25                  30          


Tyr Ala Gln Ala Gln Arg Met Val Glu Ile Glu Ile Glu Gly Arg Leu 
        35                  40                  45              


His Arg Ile Ser Ile Phe Asp Pro Leu Glu Ile Ile Leu Glu Asp Asp 
    50                  55                  60                  


Leu Thr Ala Gln Glu Met Ser Glu Cys Asn Ser Asn Lys Glu Asn Ser 
65                  70                  75                  80  


Glu Arg Pro Pro Val Cys Leu Arg Thr Lys Arg His Lys Asn Asn Arg 
                85                  90                  95      


Val Lys Lys Lys Asn Glu Ala Leu Pro Ser Ala His Gly Thr Pro Ala 
            100                 105                 110         


Ser Ala Ser Ala Leu Pro Glu Pro Lys Val Arg Ile Val Glu Tyr Ser 
        115                 120                 125             


Pro Pro Ser Ala Pro Arg Arg Pro Pro Val Tyr Tyr Lys Phe Ile Glu 
    130                 135                 140                 


Lys Ser Ala Glu Glu Leu Asp Asn Glu Val Glu Tyr Asp Met Asp Glu 
145                 150                 155                 160 


Glu Asp Tyr Ala Trp Leu Glu Ile Val Asn Glu Lys Arg Lys Gly Asp 
                165                 170                 175     


Cys Val Pro Ala Val Ser Gln Ser Met Phe Glu Phe Leu Met Asp Arg 
            180                 185                 190         


Phe Glu Lys Glu Ser His Cys Glu Asn Gln Lys Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Leu Ile Asp Glu Asp Ala Val Cys Cys Ile Cys Met Asp Gly Glu 
    210                 215                 220                 


Cys Gln Asn Ser Asn Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala 
225                 230                 235                 240 


Val His Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp 
                245                 250                 255     


Leu Cys Arg His Cys Leu Gln Ser Arg Ala Arg Pro Ala Asp Cys Val 
            260                 265                 270         


Leu Cys Pro Asn Lys Gly Gly Ala Phe Lys Lys Thr Asp Asp Asp Arg 
        275                 280                 285             


Trp Gly His Val Val Cys Ala Leu Trp Ile Pro Glu Val Gly Phe Ala 
    290                 295                 300                 


Asn Thr Val Phe Ile Glu Pro Ile Asp Gly Val Arg Asn Ile Pro Pro 
305                 310                 315                 320 


Ala Arg Trp Lys Leu Thr Cys Tyr Leu Cys Lys Gln Lys Gly Val Gly 
                325                 330                 335     


Ala Cys Ile Gln Cys His Lys Ala Asn Cys Tyr Thr Ala Phe His Val 
            340                 345                 350         


Thr Cys Ala Gln Lys Ala Gly Leu Tyr Met Lys Met Glu Pro Val Lys 
        355                 360                 365             


Glu Leu Thr Gly Gly Gly Thr Thr Phe Ser Val Arg Lys Thr Ala Tyr 
    370                 375                 380                 


Cys Asp Val His Thr Pro Pro Gly Cys Thr Arg Arg Pro Leu Asn Ile 
385                 390                 395                 400 


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
                405                 410                 415     


Val Lys Thr Val Arg Ser Thr Ser Lys Val Arg Lys Lys Ala Lys Lys 
            420                 425                 430         


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Thr Val Cys 
        435                 440                 445             


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
    450                 455                 460                 


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
465                 470                 475                 480 


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
                485                 490                 495     


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
            500                 505                 510         


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
        515                 520                 525             


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
    530                 535                 540                 


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
545                 550                 555                 560 


Glu Leu Arg Leu Thr Pro Leu Thr Val Leu Leu Arg Ser Val Leu Asp 
                565                 570                 575     


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
            580                 585                 590         


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
        595                 600                 605             


Phe Ala Thr Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
    610                 615                 620                 


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
625                 630                 635                 640 


Tyr Asn Ala Arg Asp Thr Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
                645                 650                 655     


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
            660                 665                 670         


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
        675                 680                 685             


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
    690                 695                 700                 


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
705                 710                 715                 720 


Leu Leu Asp Met Leu Asp Leu Thr Cys Ala Met Lys Ser Ser Gly Ser 
                725                 730                 735     


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
            740                 745                 750         


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Thr Gly Pro Gly 
        755                 760                 765             


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
    770                 775                 780                 


Glu Glu Val Leu Pro Arg Leu Glu Thr Leu Leu Gln Pro Arg Lys Arg 
785                 790                 795                 800 


Ser Arg Ser Thr Cys Gly Asp Ser Glu Val Glu Glu Glu Ser Pro Gly 
                805                 810                 815     


Lys Arg Leu Asp Ala Gly Leu Thr Asn Gly Phe Gly Gly Ala Arg Ser 
            820                 825                 830         


Glu Gln Glu Pro Gly Gly Gly Leu Gly Arg Lys Ala Thr Pro Arg Arg 
        835                 840                 845             


Arg Cys Ala Ser Glu Ser Ser Ile Ser Ser Ser Asn Ser Pro Leu Cys 
    850                 855                 860                 


Asp Ser Ser Phe Asn Ala Pro Lys Cys Gly Arg Gly Lys Pro Ala Leu 
865                 870                 875                 880 


Val Arg Arg His Thr Leu Glu Asp Arg Ser Glu Leu Ile Ser Cys Ile 
                885                 890                 895     


Glu Asn Gly Asn Tyr Ala Lys Ala Ala Arg Ile Ala Ala Glu Val Gly 
            900                 905                 910         


Gln Ser Ser Met Trp Ile Ser Thr Asp Ala Ala Ala Ser Val Leu Glu 
        915                 920                 925             


Pro Leu Lys Val Val Trp Ala Lys Cys Ser Gly Tyr Pro Ser Tyr Pro 
    930                 935                 940                 


Ala Leu Ile Ile Asp Pro Lys Met Pro Arg Val Pro Gly His His Asn 
945                 950                 955                 960 


Gly Val Thr Ile Pro Ala Pro Pro Leu Asp Val Leu Lys Ile Gly Glu 
                965                 970                 975     


His Met Gln Thr Lys Ser Asp Glu Lys Leu Phe Leu Val Leu Phe Phe 
            980                 985                 990         


Asp Asn Lys Arg Ser Trp Gln Trp  Leu Pro Lys Ser Lys  Met Val Pro 
        995                 1000                 1005             


Leu Gly  Ile Asp Glu Thr Ile  Asp Lys Leu Lys Met  Met Glu Gly 
    1010                 1015                 1020             


Arg Asn  Ser Ser Ile Arg Lys  Ala Val Arg Ile Ala  Phe Asp Arg 
    1025                 1030                 1035             


Ala Met  Asn His Leu Ser Arg  Val His Gly Glu Pro  Thr Ser Asp 
    1040                 1045                 1050             


Leu Ser  Asp Ile Asp 
    1055             


<210>  634
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Gly 
705                 710                 715                 720 


Pro Ala 
        


<210>  635
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  635

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
1               5                   10                  15      


Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
            20                  25                  30          


Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
        35                  40                  45              


Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
    50                  55                  60                  


Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
65                  70                  75                  80  


Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                85                  90                  95      


Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
            100                 105                 110         


Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
        115                 120                 125             


Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val Asp 
    130                 135                 140                 


Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
145                 150                 155                 160 


Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                165                 170     


<210>  636
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Ser Gln Glu Gly Val Glu Leu Glu Lys Ser Val Arg Arg Leu Arg 
1               5                   10                  15      


Glu Lys Phe His Gly Lys Val Ser Ser Lys Lys Ala Gly Ala Leu Met 
            20                  25                  30          


Arg Lys Phe Gly Ser Asp His Thr Gly Val Gly Arg Ser Ile Val Tyr 
        35                  40                  45              


Gly Val Lys Gln Lys Asp Gly Gln Glu Leu Ser Asn Asp Leu Asp Ala 
    50                  55                  60                  


Gln Asp Pro Pro Glu Asp Met Lys Gln Asp Arg Asp Ile Gln Ala Val 
65                  70                  75                  80  


Ala Thr Ser Leu Leu Pro Leu Thr Glu Ala Asn Leu Arg Met Phe Gln 
                85                  90                  95      


Arg Ala Gln Asp Asp Leu Ile Pro Ala Val Asp Arg Gln Phe Ala Cys 
            100                 105                 110         


Ser Ser Cys Asp His Val Trp Trp Arg Arg Val Pro Gln Arg Lys Glu 
        115                 120                 125             


Val Ser Arg Cys Arg Lys Cys Arg Lys Arg Tyr Glu Pro Val Pro Ala 
    130                 135                 140                 


Asp Lys Met Trp Gly Leu Ala Glu Phe His Cys Pro Lys Cys Arg His 
145                 150                 155                 160 


Asn Phe Arg Gly Trp Ala Gln Met Gly Ser Pro Ser Pro Cys Tyr Gly 
                165                 170                 175     


Cys Gly Phe Pro Val Tyr Pro Thr Arg Ile Leu Pro Pro Arg Trp Asp 
            180                 185                 190         


Arg Asp Pro Asp Arg Arg Ser Thr His Thr His Ser Cys Ser Ala Ala 
        195                 200                 205             


Asp Cys Tyr Asn Arg Arg Glu Pro His Val Pro Gly Thr Ser Cys Ala 
    210                 215                 220                 


His Pro Lys Ser Arg Lys Gln Asn His Leu Pro Lys Val Leu His Pro 
225                 230                 235                 240 


Ser Asn Pro His Ile Ser Ser Gly Ser Thr Val Ala Thr Cys Leu Ser 
                245                 250                 255     


Gln Gly Gly Leu Leu Glu Asp Leu Asp Asn Leu Ile Leu Glu Asp Leu 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Glu Gly Gly 
        275                 280                 285             


Pro Arg Glu 
    290     


<210>  637
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  637

Met Glu Ala Gly Pro His Pro Arg Pro Gly His Cys Cys Lys Pro Gly 
1               5                   10                  15      


Gly Arg Leu Asp Met Asn His Gly Phe Val His His Ile Arg Arg Asn 
            20                  25                  30          


Gln Ile Ala Arg Asp Asp Tyr Asp Lys Lys Val Lys Gln Ala Ala Lys 
        35                  40                  45              


Glu Lys Val Arg Arg Arg His Thr Pro Ala Pro Thr Arg Pro Arg Lys 
    50                  55                  60                  


Pro Asp Leu Gln Val Tyr Leu Pro Arg His Arg Asp Val Ser Ala His 
65                  70                  75                  80  


Pro Arg Asn Pro Asp Tyr Glu Glu Ser Gly Glu Ser Ser Ser Ser Gly 
                85                  90                  95      


Gly Ser Glu Leu Glu Pro Ser Gly His Gln Leu Phe Cys Leu Glu Tyr 
            100                 105                 110         


Glu Ala Asp Ser Gly Glu Val Thr Ser Val Ile Val Tyr Gln Gly Asp 
        115                 120                 125             


Asp Pro Gly Lys Val Ser Glu Lys Val Ser Ala His Thr Pro Leu Asp 
    130                 135                 140                 


Pro Pro Met Arg Glu Ala Leu Lys Leu Arg Ile Gln Glu Glu Ile Ala 
145                 150                 155                 160 


Lys Arg Gln Ser Gln His 
                165     


<210>  638
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  639
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  639

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Glu Pro Gln Thr Thr Val 
                325                 330                 335     


Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
            340                 345                 350         


Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
        355                 360                 365             


Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
    370                 375                 380                 


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
385                 390                 395                 400 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
                405                 410                 415     


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
            420                 425                 430         


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
        435                 440                 445             


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
    450                 455                 460                 


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
465                 470                 475                 480 


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
                485                 490                 495 


<210>  640
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Thr Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Thr Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Thr Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Thr Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Thr Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Thr Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Thr Thr Gly Leu Ala Trp Ser 
        195                 200                 205             


Lys Thr Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro 
    210                 215                 220                 


Ser Ala Gly Ser Cys Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Pro Val Ser Thr Ile Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser 
                245                 250                 255     


Leu Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Thr His Ala Leu Lys 
            260                 265                 270         


His Val Ser Asp Asp Met Lys Thr His Lys Asn Pro Ala Leu Lys Ala 
        275                 280                 285             


Gln Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys 
    290                 295                 300                 


Pro Gln Thr Ser Pro Ser Pro Lys Arg Ala Thr Lys Lys Glu Pro Ala 
305                 310                 315                 320 


Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn 
                325                 330                 335     


Val Ser Asn Leu Val Ile Glu Asp Thr Glu Leu Lys Gln Val Ala Tyr 
            340                 345                 350         


Ile Tyr Lys Cys Val Asn Thr Thr Leu Gln Ile Lys Gly Lys Ile Asn 
        355                 360                 365             


Ser Ile Thr Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp 
    370                 375                 380                 


Val Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln 
385                 390                 395                 400 


Val Met Gly Lys Val Pro Thr Ile Ser Ile Asn Lys Thr Asp Gly Cys 
                405                 410                 415     


His Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala 
            420                 425                 430         


Lys Ser Ser Glu Met Asn Val Leu Ile Pro Thr Glu Gly Gly Asp Phe 
        435                 440                 445             


Asn Glu Phe Pro Val Pro Glu Gln Phe Lys Thr Leu Trp Asn Gly Gln 
    450                 455                 460                 


Lys Leu Val Thr Thr Val Thr Glu Ile Ala Gly 
465                 470                 475 


<210>  641
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  641

Met Ala Asp Arg Arg Arg Gln Arg Ala Ser Gln Asp Thr Glu Asp Glu 
1               5                   10                  15      


Glu Ser Gly Ala Ser Gly Ser Asp Ser Gly Gly Ser Pro Leu Arg Gly 
            20                  25                  30          


Gly Gly Ser Cys Ser Gly Ser Ala Gly Gly Gly Gly Ser Gly Ser Leu 
        35                  40                  45              


Pro Ser Gln Arg Gly Gly Arg Thr Gly Ala Leu His Leu Arg Arg Val 
    50                  55                  60                  


Glu Ser Gly Gly Ala Lys Ser Ala Glu Glu Ser Glu Cys Glu Ser Glu 
65                  70                  75                  80  


Asp Gly Ile Glu Gly Asp Ala Val Leu Ser Asp Tyr Glu Ser Ala Glu 
                85                  90                  95      


Asp Ser Glu Gly Glu Glu Gly Glu Tyr Ser Glu Glu Glu Asn Ser Lys 
            100                 105                 110         


Val Glu Leu Lys Ser Glu Ala Asn Asp Ala Val Asn Ser Ser Thr Lys 
        115                 120                 125             


Glu Glu Lys Gly Glu Glu Lys Pro Asp Thr Lys Ser Thr Val Thr Gly 
    130                 135                 140                 


Glu Arg Gln Ser Gly Asp Gly Gln Glu Ser Thr Glu Pro Val Glu Asn 
145                 150                 155                 160 


Lys Val Gly Lys Lys Gly Pro Lys His Leu Asp Asp Asp Glu Asp Arg 
                165                 170                 175     


Lys Asn Pro Ala Tyr Ile Pro Arg Lys Gly Leu Phe Phe Glu His Asp 
            180                 185                 190         


Leu Arg Gly Gln Thr Gln Glu Glu Glu Val Arg Pro Lys Gly Arg Gln 
        195                 200                 205             


Arg Lys Leu Trp Lys Asp Glu Gly Arg Trp Glu His Asp Lys Phe Arg 
    210                 215                 220                 


Glu Asp Glu Gln Ala Pro Lys Ser Arg Gln Glu Leu Ile Ala Leu Tyr 
225                 230                 235                 240 


Gly Tyr Asp Ile Arg Ser Ala His Asn Pro Asp Asp Ile Lys Pro Arg 
                245                 250                 255     


Arg Ile Arg Lys Pro Arg Tyr Gly Ser Pro Pro Gln Arg Asp Pro Asn 
            260                 265                 270         


Trp Asn Gly Glu Arg Leu Asn Lys Ser His Arg His Gln Gly Leu Gly 
        275                 280                 285             


Gly Thr Leu Pro Pro Arg Thr Phe Ile Asn Arg Asn Ala Ala Gly Thr 
    290                 295                 300                 


Gly Arg Met Ser Ala Pro Arg Asn Tyr Ser Arg Ser Gly Gly Phe Lys 
305                 310                 315                 320 


Glu Gly Arg Ala Gly Phe Arg Pro Val Glu Ala Gly Gly Gln His Gly 
                325                 330                 335     


Gly Arg Ser Gly Glu Thr Val Lys His Glu Ile Ser Tyr Arg Ser Arg 
            340                 345                 350         


Arg Leu Glu Gln Thr Ser Val Arg Asp Pro Ser Pro Glu Ala Asp Ala 
        355                 360                 365             


Pro Val Leu Gly Ser Pro Glu Lys Glu Glu Ala Ala Ser Glu Pro Pro 
    370                 375                 380                 


Ala Ala Ala Pro Asp Ala Ala Pro Pro Pro Pro Asp Arg Pro Ile Glu 
385                 390                 395                 400 


Lys Lys Ser Tyr Ser Arg Ala Arg Arg Thr Arg Thr Lys Val Gly Asp 
                405                 410                 415     


Ala Val Lys Leu Ala Glu Glu Val Pro Pro Pro Pro Glu Gly Leu Ile 
            420                 425                 430         


Pro Ala Pro Pro Val Pro Glu Thr Thr Pro Thr Pro Pro Thr Lys Thr 
        435                 440                 445             


Gly Thr Trp Glu Ala Pro Val Asp Ser Ser Thr Ser Gly Leu Glu Gln 
    450                 455                 460                 


Asp Val Ala Gln Leu Asn Ile Ala Glu Gln Asn Trp Ser Pro Gly Gln 
465                 470                 475                 480 


Pro Ser Phe Leu Gln Pro Arg Glu Leu Arg Gly Met Pro Asn His Ile 
                485                 490                 495     


His Met Gly Ala Gly Pro Pro Pro Gln Phe Asn Arg Met Glu Glu Met 
            500                 505                 510         


Gly Val Gln Gly Gly Arg Ala Lys Arg Tyr Ser Ser Gln Arg Gln Arg 
        515                 520                 525             


Pro Val Pro Glu Pro Pro Ala Pro Pro Val His Ile Ser Ile Met Glu 
    530                 535                 540                 


Gly His Tyr Tyr Asp Pro Leu Gln Phe Gln Gly Pro Ile Tyr Thr His 
545                 550                 555                 560 


Gly Asp Ser Pro Ala Pro Leu Pro Pro Gln Gly Met Leu Val Gln Pro 
                565                 570                 575     


Gly Met Asn Leu Pro His Pro Gly Leu His Pro His Gln Thr Pro Ala 
            580                 585                 590         


Pro Leu Pro Asn Pro Gly Leu Tyr Pro Pro Pro Val Ser Met Ser Pro 
        595                 600                 605             


Gly Gln Pro Pro Pro Gln Gln Leu Leu Ala Pro Thr Tyr Phe Ser Ala 
    610                 615                 620                 


Pro Gly Val Met Asn Phe Gly Asn Pro Ser Tyr Pro Tyr Ala Pro Gly 
625                 630                 635                 640 


Ala Leu Pro Pro Pro Pro Pro Pro His Leu Tyr Pro Asn Thr Gln Ala 
                645                 650                 655     


Pro Ser Gln Val Tyr Gly Gly Val Thr Tyr Tyr Asn Pro Ala Gln Gln 
            660                 665                 670         


Gln Val Gln Pro Lys Pro Ser Pro Pro Arg Arg Thr Pro Gln Pro Val 
        675                 680                 685             


Thr Ile Lys Pro Pro Pro Pro Glu Val Val Ser Arg Gly Ser Ser 
    690                 695                 700             


<210>  642
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 
            100                 105                 110         


Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 
        115                 120                 125             


Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
    130                 135                 140                 


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
145                 150                 155                 160 


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
                165                 170                 175     


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
            180                 185                 190         


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
        195                 200                 205             


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
    210                 215                 220                 


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
225                 230                 235                 240 


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
                245                 250                 255     


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
            260                 265                 270         


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
        275                 280                 285             


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
    290                 295                 300                 


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
305                 310                 315                 320 


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
                325                 330                 335     


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
            340                 345                 350         


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
        355                 360                 365             


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
    370                 375                 380                 


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
385                 390                 395                 400 


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
                405                 410                 415     


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
            420                 425                 430         


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
        435                 440                 445             


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
    450                 455                 460                 


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
465                 470                 475                 480 


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
                485                 490                 495     


<210>  643
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  643

Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Pro Pro Lys Tyr Ser Thr Trp Glu Pro Glu Glu His Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu Lys Glu Glu Arg Asp 
    50                  55                  60                  


Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu 
65                  70                  75                  80  


Leu Gln Arg Leu Tyr Ser Met Asp Leu Arg Ser Ser His Lys Ala Lys 
                85                  90                  95      


Gly Lys Glu Lys Leu Cys Phe Ser Leu Thr Cys Pro Leu Gly Ser Gly 
            100                 105                 110         


Ser Pro Glu Gly Val Val Lys Ala Gly Ala Pro Glu Leu Val Asp Lys 
        115                 120                 125             


Gly Pro Leu Val Pro Thr Leu Pro Phe Pro Leu Arg Lys Pro Arg Lys 
    130                 135                 140                 


Ala His Lys Tyr Leu Arg Leu Ser Arg Lys Lys Phe Pro Pro Arg Gly 
145                 150                 155                 160 


Pro Asn Leu Glu Ser His Ser His Arg Arg Glu Leu Phe Leu Gln Glu 
                165                 170                 175     


Pro Pro Ala Pro Asp Val Leu Gln Ala Ala Gly Glu Trp Glu Pro Ala 
            180                 185                 190         


Ala Gln Pro Pro Glu Glu Glu Ala Asp Ala Asp Leu Ala Glu Gly Pro 
        195                 200                 205             


Pro Pro Trp Thr Pro Ala Leu Pro Ser Ser Glu Val Thr Val Thr Asp 
    210                 215                 220                 


Ile Thr Ala Asn Ser Ile Thr Val Thr Phe Arg Glu Ala Gln Ala Ala 
225                 230                 235                 240 


Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 
                245                 250     


<210>  644
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                85                  90                  95      


Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
            100                 105                 110         


Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
    130                 135                 140                 


Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
145                 150                 155                 160 


Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                165                 170                 175     


Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
        195                 200                 205             


Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
    210                 215                 220                 


Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
225                 230                 235                 240 


Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                245                 250                 255     


Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
            260                 265                 270         


Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
        275                 280                 285             


Ala Ile His Leu 
    290         


<210>  645
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  645

Met Lys Asp Leu Gly Ala Glu His Leu Ala Gly His Glu Gly Val Gln 
1               5                   10                  15      


Leu Leu Gly Leu Leu Asn Val Tyr Leu Glu Gln Glu Glu Arg Phe Gln 
            20                  25                  30          


Pro Arg Glu Lys Gly Leu Ser Leu Ile Glu Ala Thr Pro Glu Asn Asp 
        35                  40                  45              


Asn Thr Leu Cys Pro Gly Leu Arg Asn Ala Lys Val Glu Asp Leu Arg 
    50                  55                  60                  


Ser Leu Ala Asn Phe Phe Gly Ser Cys Thr Glu Thr Phe Val Leu Ala 
65                  70                  75                  80  


Val Asn Ile Leu Asp Arg Phe Leu Ala Leu Met Lys Val Lys Pro Lys 
                85                  90                  95      


His Leu Ser Cys Ile Gly Val Cys Ser Phe Leu Leu Ala Ala Arg Ile 
            100                 105                 110         


Val Glu Glu Asp Cys Asn Ile Pro Ser Thr His Asp Val Ile Arg Ile 
        115                 120                 125             


Ser Gln Cys Lys Cys Thr Ala Ser Asp Ile Lys Arg Met Glu Lys Ile 
    130                 135                 140                 


Ile Ser Glu Lys Leu His Tyr Glu Leu Glu Ala Thr Thr Ala Leu Asn 
145                 150                 155                 160 


Phe Leu His Leu Tyr His Thr Ile Ile Leu Cys His Thr Ser Glu Arg 
                165                 170                 175     


Lys Glu Ile Leu Ser Leu Asp Lys Leu Glu Ala Gln Leu Lys Ala Cys 
            180                 185                 190         


Asn Cys Arg Leu Ile Phe Ser Lys Ala Lys Pro Ser Val Leu Ala Leu 
        195                 200                 205             


Cys Leu Leu Asn Leu Glu Val Glu Thr Leu Lys Ser Val Glu Leu Leu 
    210                 215                 220                 


Glu Ile Leu Leu Leu Val Lys Lys His Ser Lys Ile Asn Asp Thr Glu 
225                 230                 235                 240 


Phe Phe Tyr Trp Arg Glu Leu Val Ser Lys Cys Leu Ala Glu Tyr Ser 
                245                 250                 255     


Ser Pro Glu Cys Cys Lys Pro Asp Leu Lys Lys Leu Val Trp Ile Val 
            260                 265                 270         


Ser Arg Arg Thr Ala Gln Asn Leu His Asn Ser Tyr Tyr Ser Val Pro 
        275                 280                 285             


Glu Leu Pro Thr Ile Pro Glu Gly Gly Cys Phe Asp Glu Ser Glu Ser 
    290                 295                 300                 


Glu Asp Ser Cys Glu Asp Met Ser Cys Gly Glu Glu Ser Leu Ser Ser 
305                 310                 315                 320 


Ser Pro Pro Ser Asp Gln Glu Cys Thr Phe Phe Phe Asn Phe Lys Val 
                325                 330                 335     


Ala Gln Thr Leu Cys Phe Pro Ser 
            340                 


<210>  646
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Ala Ser Gly Arg Gly Ala Ser Ser Arg Trp Phe Phe Thr Arg Glu 
1               5                   10                  15      


Gln Leu Glu Asn Thr Pro Ser Arg Arg Cys Gly Val Glu Ala Asp Lys 
            20                  25                  30          


Glu Leu Ser Cys Arg Gln Gln Ala Ala Asn Leu Ile Gln Glu Met Gly 
        35                  40                  45              


Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val Tyr 
    50                  55                  60                  


Met His Arg Phe Tyr Met His His Ser Phe Thr Lys Phe Asn Lys Asn 
65                  70                  75                  80  


Ile Ile Ser Ser Thr Ala Leu Phe Leu Ala Ala Lys Val Glu Glu Gln 
                85                  90                  95      


Ala Arg Lys Leu Glu His Val Ile Lys Val Ala His Ala Cys Leu His 
            100                 105                 110         


Pro Leu Glu Pro Leu Leu Asp Thr Lys Cys Asp Ala Tyr Leu Gln Gln 
        115                 120                 125             


Thr Gln Glu Leu Val Ile Leu Glu Thr Ile Met Leu Gln Thr Leu Gly 
    130                 135                 140                 


Phe Glu Ile Thr Ile Glu His Pro His Thr Asp Val Val Lys Cys Thr 
145                 150                 155                 160 


Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe Met 
                165                 170                 175     


Ala Thr Asn Ser Leu His Leu Thr Thr Phe Cys Leu Gln Tyr Lys Pro 
            180                 185                 190         


Thr Val Ile Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser Asn 
        195                 200                 205             


Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr Val 
    210                 215                 220                 


Asp Pro Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu Phe 
225                 230                 235                 240 


Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Lys Ile Arg Asn 
                245                 250                 255     


Trp Arg Ala Asn Gln Ala Ala Arg Lys Pro Lys Val Asp Gly Gln Val 
            260                 265                 270         


Ser Glu Thr Pro Leu Leu Gly Ser Ser Leu Val Gln Asn Ser Ile Leu 
        275                 280                 285             


Val Asp Ser Val Thr Gly Val Pro Thr Asn Pro Ser Phe Gln Lys Pro 
    290                 295                 300                 


Ser Thr Ser Ala Phe Pro Ala Pro Val Pro Leu Asn Ser Gly Asn Ile 
305                 310                 315                 320 


Ser Val Gln Asp Ser His Thr Ser Asp Asn Leu Ser Met Leu Ala Thr 
                325                 330                 335     


Gly Met Pro Ser Thr Ser Tyr Gly Leu Ser Ser His Gln Glu Trp Pro 
            340                 345                 350         


Gln His Gln Asp Ser Ala Arg Thr Glu Gln Leu Tyr Ser Gln Lys Gln 
        355                 360                 365             


Glu Thr Ser Leu Ser Gly Ser Gln Tyr Asn Ile Asn Phe Gln Gln Gly 
    370                 375                 380                 


Pro Ser Ile Ser Leu His Ser Gly Leu His His Arg Pro Asp Lys Ile 
385                 390                 395                 400 


Ser Asp His Ser Ser Val Lys Gln Glu Tyr Thr His Lys Ala Gly Ser 
                405                 410                 415     


Ser Lys His His Gly Pro Ile Ser Thr Thr Pro Gly Ile Ile Pro Gln 
            420                 425                 430         


Lys Met Ser Leu Asp Lys Tyr Arg Glu Lys Arg Lys Leu Glu Thr Leu 
        435                 440                 445             


Asp Leu Asp Val Arg Asp His Tyr Ile Ala Ala Gln Val Glu Gln Gln 
    450                 455                 460                 


His Lys Gln Gly Gln Ser Gln Ala Ala Ser Ser Ser Ser Val Thr Ser 
465                 470                 475                 480 


Pro Ile Lys Met Lys Ile Pro Ile Ala Asn Thr Glu Lys Tyr Met Ala 
                485                 490                 495     


Asp Lys Lys Glu Lys Ser Gly Ser Leu Lys Leu Arg Ile Pro Ile Pro 
            500                 505                 510         


Pro Thr Asp Lys Ser Ala Ser Lys Glu Glu Leu Lys Met Lys Ile Lys 
        515                 520                 525             


Val Ser Ser Ser Glu Arg His Ser Ser Ser Asp Glu Gly Ser Gly Lys 
    530                 535                 540                 


Ser Lys His Ser Ser Pro His Ile Ser Arg Asp His Lys Glu Lys His 
545                 550                 555                 560 


Lys Glu His Pro Ser Ser Arg His His Thr Ser Ser His Lys His Ser 
                565                 570                 575     


His Ser His Ser Gly Ser Ser Ser Gly Gly Ser Lys His Ser Ala Asp 
            580                 585                 590         


Gly Ile Pro Pro Thr Val Leu Arg Ser Pro Val Gly Leu Ser Ser Asp 
        595                 600                 605             


Gly Ile Ser Ser Ser Ser Ser Ser Ser Arg Lys Arg Leu His Val Asn 
    610                 615                 620                 


Asp Ala Ser His Asn His His Ser Lys Met Ser Lys Ser Ser Lys Ser 
625                 630                 635                 640 


Ser Gly Gly Leu Arg Thr Ser Gln His Pro Arg Glu Thr Gly Gln Glu 
                645                 650                 655     


Ala Ser Gly Asp Gln Arg Ser 
            660             


<210>  647
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  647

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  648
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  649
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  649

Met Ala Thr Ser Met Gly Leu Leu Leu Leu Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Gln Pro Gly Ala Gly Thr Gly Ala Asp Thr Glu Ala Val Val Cys Val 
            20                  25                  30          


Gly Thr Ala Cys Tyr Thr Ala His Ser Gly Lys Leu Ser Ala Ala Glu 
        35                  40                  45              


Ala Gln Asn His Cys Asn Gln Asn Gly Gly Asn Leu Ala Thr Val Lys 
    50                  55                  60                  


Ser Lys Glu Glu Ala Gln His Val Gln Arg Val Leu Ala Gln Leu Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Ala Leu Thr Ala Arg Met Ser Lys Phe Trp Ile Gly 
                85                  90                  95      


Leu Gln Arg Glu Lys Gly Lys Cys Leu Asp Pro Ser Leu Pro Leu Lys 
            100                 105                 110         


Gly Phe Ser Trp Val Gly Gly Gly Glu Asp Thr Pro Tyr Ser Asn Trp 
        115                 120                 125             


His Lys Glu Leu Arg Asn Ser Cys Ile Ser Lys Arg Cys Val Ser Leu 
    130                 135                 140                 


Leu Leu Asp Leu Ser Gln Pro Leu Leu Pro Ser Arg Leu Pro Lys Trp 
145                 150                 155                 160 


Ser Glu Gly Pro Cys Gly Ser Pro Gly Ser Pro Gly Ser Asn Ile Glu 
                165                 170                 175     


Gly Phe Val Cys Lys Phe Ser Phe Lys Gly Met Cys Arg Pro Leu Ala 
            180                 185                 190         


Leu Gly Gly Pro Gly Gln Val Thr Tyr Thr Thr Pro Phe Gln Thr Thr 
        195                 200                 205             


Ser Ser Ser Leu Glu Ala Val Pro Phe Ala Ser Ala Ala Asn Val Ala 
    210                 215                 220                 


Cys Gly Glu Gly Asp Lys Asp Glu Thr Gln Ser His Tyr Phe Leu Cys 
225                 230                 235                 240 


Lys Glu Lys Ala Pro Asp Val Phe Asp Trp Gly Ser Ser Gly Pro Leu 
                245                 250                 255     


Cys Val Ser Pro Lys Tyr Gly Cys Asn Phe Asn Asn Gly Gly Cys His 
            260                 265                 270         


Gln Asp Cys Phe Glu Gly Gly Asp Gly Ser Phe Leu Cys Gly Cys Arg 
        275                 280                 285             


Pro Gly Phe Arg Leu Leu Asp Asp Leu Val Thr Cys Ala Ser Arg Asn 
    290                 295                 300                 


Pro Cys Ser Ser Ser Pro Cys Arg Gly Gly Ala Thr Cys Val Leu Gly 
305                 310                 315                 320 


Pro His Gly Lys Asn Tyr Thr Cys Arg Cys Pro Gln Gly Tyr Gln Leu 
                325                 330                 335     


Asp Ser Ser Gln Leu Asp Cys Val Asp Val Asp Glu Cys Gln Asp Ser 
            340                 345                 350         


Pro Cys Ala Gln Glu Cys Val Asn Thr Pro Gly Gly Phe Arg Cys Glu 
        355                 360                 365             


Cys Trp Val Gly Tyr Glu Pro Gly Gly Pro Gly Glu Gly Ala Cys Gln 
    370                 375                 380                 


Asp Val Asp Glu Cys Ala Leu Gly Arg Ser Pro Cys Ala Gln Gly Cys 
385                 390                 395                 400 


Thr Asn Thr Asp Gly Ser Phe His Cys Ser Cys Glu Glu Gly Tyr Val 
                405                 410                 415     


Leu Ala Gly Glu Asp Gly Thr Gln Cys Gln Asp Val Asp Glu Cys Val 
            420                 425                 430         


Gly Pro Gly Gly Pro Leu Cys Asp Ser Leu Cys Phe Asn Thr Gln Gly 
        435                 440                 445             


Ser Phe His Cys Gly Cys Leu Pro Gly Trp Val Leu Ala Pro Asn Gly 
    450                 455                 460                 


Val Ser Cys Thr Met Gly Pro Val Ser Leu Gly Pro Pro Ser Gly Pro 
465                 470                 475                 480 


Pro Asp Glu Glu Asp Lys Gly Glu Lys Glu Gly Ser Thr Val Pro Arg 
                485                 490                 495     


Ala Ala Thr Ala Ser Pro Thr Arg Gly Pro Glu Gly Thr Pro Lys Ala 
            500                 505                 510         


Thr Pro Thr Thr Ser Arg Pro Ser Leu Ser Ser Asp Ala Pro Ile Thr 
        515                 520                 525             


Ser Ala Pro Leu Lys Met Leu Ala Pro Ser Gly Ser Pro Gly Val Trp 
    530                 535                 540                 


Arg Glu Pro Ser Ile His His Ala Thr Ala Ala Ser Gly Pro Gln Glu 
545                 550                 555                 560 


Pro Ala Gly Gly Asp Ser Ser Val Ala Thr Gln Asn Asn Asp Gly Thr 
                565                 570                 575     


Asp Gly Gln Lys Leu Leu Leu Phe Tyr Ile Leu Gly Thr Val Val Ala 
            580                 585                 590         


Ile Leu Leu Leu Leu Ala Leu Ala Leu Gly Leu Leu Val Tyr Arg Lys 
        595                 600                 605             


Arg Arg Ala Lys Arg Glu Glu Lys Lys Glu Lys Lys Pro Gln Asn Ala 
    610                 615                 620                 


Ala Asp Ser Tyr Ser Trp Val Pro Glu Arg Ala Glu Ser Arg Ala Met 
625                 630                 635                 640 


Glu Asn Gln Tyr Ser Pro Thr Pro Gly Thr Asp Cys 
                645                 650         


<210>  650
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
        115                 120                 125             


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
145                 150                 155                 160 


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
                165                 170                 175     


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
            180                 185                 190         


Gly Arg Asp Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val 
        195                 200                 205             


Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala 
    210                 215                 220                 


Leu Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn 
225                 230                 235                 240 


Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro 
                245                 250                 255     


Phe Thr Tyr Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln 
            260                 265                 270         


Glu Arg Gly Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met 
        275                 280                 285             


Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala 
    290                 295                 300                 


Val Ala Gly Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn 
305                 310                 315                 320 


Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile 
                325                 330                 335     


Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val 
            340                 345                 350         


Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro 
        355                 360                 365             


Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly 
    370                 375                 380                 


Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu 
385                 390                 395                 400 


Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala 
                405                 410                 415     


Thr Glu Gly Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys 
            420                 425                 430         


Gln Cys Ser His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp 
        435                 440                 445             


Val Glu Asp Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu 
    450                 455                 460                 


Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg 
465                 470                 475                 480 


Pro Ile Gln Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys 
                485                 490                 495     


Leu Phe Val Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly 
            500                 505                 510         


Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr 
        515                 520                 525             


Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu 
    530                 535                 540                 


Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg 
545                 550                 555                 560 


Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val 
                565                 570                 575     


Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp 
            580                 585                 590         


Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr 
        595                 600                 605             


Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys 
    610                 615                 620                 


Leu Thr Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys 
625                 630                 635                 640 


Lys Ala Arg Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu 
                645                 650                 655     


Gly Cys Thr Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu 
            660                 665                 670         


Val Leu Thr Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe 
        675                 680                 685             


Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr 
    690                 695                 700                 


Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe 
705                 710                 715                 720 


Thr Ser Thr Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg 
                725                 730                 735     


Ala Ser Glu Ser Gly Ile 
            740         


<210>  651
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  651

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
1               5                   10                  15      


Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
            20                  25                  30          


Pro Leu Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
        35                  40                  45              


Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
    50                  55                  60                  


Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met Cys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe Phe Gln Ile 
                85                  90                  95      


Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
            100                 105                 110         


Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
        115                 120                 125             


Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
    130                 135                 140                 


Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe His Phe 
145                 150                 155                 160 


Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                165                 170                 175     


Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile Ser Val Ile 
            180                 185                 190         


His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
        195                 200                 205             


Arg Ala Lys Lys Lys 
    210             


<210>  652
<211>  1584
<212>  PRT
<213>  Homo sapiens

<400>  652

Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His 
1               5                   10                  15      


Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu 
            20                  25                  30          


Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 
        35                  40                  45              


Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn 
    50                  55                  60                  


Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr 
65                  70                  75                  80  


Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Thr Asn Leu Phe 
                85                  90                  95      


Thr Val Val Gln Gly Glu Met Arg Val Pro Glu Glu Ala Leu Lys His 
            100                 105                 110         


Glu Lys Phe Thr Ile Gln Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser 
        115                 120                 125             


Glu Leu Ser Lys Ser Ala Ser Ala Lys Ser Ile Asp Ser Lys Val Ala 
    130                 135                 140                 


Asp Ala Ala Thr Glu Val Gln His Lys Thr Thr Glu Ala Leu Lys Ser 
145                 150                 155                 160 


Glu Glu Lys Ala Met Asp Ile Ser Ala Met Pro Arg Gly Thr Pro Leu 
                165                 170                 175     


Tyr Gly Gln Pro Ser Trp Trp Gly Asp Asp Glu Val Asp Glu Lys Arg 
            180                 185                 190         


Ala Phe Lys Thr Asn Gly Lys Pro Glu Glu Lys Asn His Glu Ala Gly 
        195                 200                 205             


Thr Ser Gly Cys Gly Ile Asp Ala Lys Gln Val Glu Glu Gln Ser Ala 
    210                 215                 220                 


Ala Ala Asn Glu Glu Val Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr 
225                 230                 235                 240 


Phe Glu Ile Pro Thr Lys Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu 
                245                 250                 255     


Ser Thr Ile His Glu Ile Pro Thr Lys Asp Thr Pro Ser Ser His Ile 
            260                 265                 270         


Thr Gly Ala Gly His Ala Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr 
        275                 280                 285             


Pro Gly Lys Val Thr Ile Arg Asp His Val Thr Lys Phe Thr Ser Asp 
    290                 295                 300                 


Gln Arg His Lys Ser Lys Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu 
305                 310                 315                 320 


Gly Ile Gln Thr Gly Met Met Ala Pro Glu Asn Lys Val Ala Asp Trp 
                325                 330                 335     


Leu Ala Gln Asn Asn Pro Pro Gln Met Leu Trp Glu Arg Thr Glu Glu 
            340                 345                 350         


Asp Ser Lys Ser Ile Lys Ser Asp Val Pro Val Tyr Leu Lys Arg Leu 
        355                 360                 365             


Lys Gly Asn Lys His Asp Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala 
    370                 375                 380                 


Gly Ala His Arg Arg Cys Ser Lys Arg Ala Thr Leu Glu Glu His Leu 
385                 390                 395                 400 


Arg Arg His His Ser Glu His Lys Lys Leu Gln Lys Val Gln Ala Thr 
                405                 410                 415     


Glu Lys His Gln Asp Gln Ala Val Thr Ser Ser Ala His His Arg Gly 
            420                 425                 430         


Gly His Gly Val Pro His Gly Lys Leu Leu Lys Gln Lys Ser Glu Glu 
        435                 440                 445             


Pro Ser Val Ser Ile Pro Phe Leu Gln Thr Ala Leu Leu Arg Ser Ser 
    450                 455                 460                 


Gly Ser Leu Gly His Arg Pro Ser Gln Glu Met Asp Lys Met Leu Lys 
465                 470                 475                 480 


Asn Gln Ala Thr Ser Ala Thr Ser Glu Lys Asp Asn Asp Asp Asp Gln 
                485                 490                 495     


Ser Asp Lys Gly Thr Tyr Thr Ile Glu Leu Glu Asn Pro Asn Ser Glu 
            500                 505                 510         


Glu Val Glu Ala Arg Lys Met Ile Asp Lys Val Phe Gly Val Asp Asp 
        515                 520                 525             


Asn Gln Asp Tyr Asn Arg Pro Val Ile Asn Glu Lys His Lys Asp Leu 
    530                 535                 540                 


Ile Lys Asp Trp Ala Leu Ser Ser Ala Ala Ala Val Met Glu Glu Arg 
545                 550                 555                 560 


Lys Pro Leu Thr Thr Ser Gly Phe His His Ser Glu Glu Gly Thr Ser 
                565                 570                 575     


Ser Ser Gly Ser Lys Arg Trp Val Ser Gln Trp Ala Ser Leu Ala Ala 
            580                 585                 590         


Asn His Thr Arg His Asp Gln Glu Glu Arg Ile Met Glu Phe Ser Ala 
        595                 600                 605             


Pro Leu Pro Leu Glu Asn Glu Thr Glu Ile Ser Glu Ser Gly Met Thr 
    610                 615                 620                 


Val Arg Ser Thr Gly Ser Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Arg Thr Leu Pro Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu 
                645                 650                 655     


Ser His Arg Ala Lys Val Val Thr Gln Arg Ser Glu Ile Gly Glu Lys 
            660                 665                 670         


Gln Asp Thr Glu Leu Gln Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln 
        675                 680                 685             


Lys Asp Lys Gln Asp Ala Asp Arg Pro Leu Ser Lys Met Asn Arg Ala 
    690                 695                 700                 


Val Asn Gly Glu Thr Leu Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu 
705                 710                 715                 720 


His Leu Gly Ser Ser Ala Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys 
                725                 730                 735     


Glu Thr Ser Leu Val Lys Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu 
            740                 745                 750         


Gln Arg Glu Glu Ala Gln Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn 
        755                 760                 765             


Val Ser Gly Gln Thr Asp Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu 
    770                 775                 780                 


Ser Gln Pro Pro Glu Lys Asn Ser Gly His Ser Thr Ser Lys Gly Asp 
785                 790                 795                 800 


Arg Val Ala Gln Ser Glu Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu 
                805                 810                 815     


Lys Ser Gln Thr Pro Lys Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser 
            820                 825                 830         


Leu Val Arg Gln Gly Ser Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile 
        835                 840                 845             


Pro Ile Glu Leu Ile Pro His Ile Asn Lys Gln Thr Ser Ser Thr Pro 
    850                 855                 860                 


Ser Ser Leu Ala Leu Thr Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu 
865                 870                 875                 880 


Ser Leu Asp Pro Asp Ser Ser Met Asp Thr Thr Leu Ile Leu Lys Asp 
                885                 890                 895     


Thr Glu Ala Val Met Ala Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn 
            900                 905                 910         


Lys Thr Asp Glu Gly Pro Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser 
        915                 920                 925             


Ile Ser Pro Glu Ser Asp Val Asp Thr Ala Ser Thr Ile Ser Leu Val 
    930                 935                 940                 


Thr Gly Glu Thr Glu Arg Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr 
945                 950                 955                 960 


Ser Leu Tyr Lys Asp Arg Cys Ser Thr Gly Ser Pro Ser Lys Asp Val 
                965                 970                 975     


Thr Lys Ser Ser Ser Ser Gly Ala Arg Glu Lys Met Glu Lys Lys Thr 
            980                 985                 990         


Lys Ser Arg Ser Thr Asp Val Gly  Ser Arg Ala Asp Gly  Arg Lys Phe 
        995                 1000                 1005             


Val Gln  Ser Ser Gly Arg Ile  Arg Gln Pro Ser Val  Asp Leu Thr 
    1010                 1015                 1020             


Asp Asp  Asp Gln Thr Ser Ser  Val Pro His Ser Ala  Ile Ser Asp 
    1025                 1030                 1035             


Ile Met  Ser Ser Asp Gln Glu  Thr Tyr Ser Cys Lys  Pro His Gly 
    1040                 1045                 1050             


Arg Thr  Pro Leu Thr Ser Ala  Asp Glu His Val His  Ser Lys Leu 
    1055                 1060                 1065             


Glu Gly  Ser Lys Val Thr Lys  Ser Lys Thr Ser Pro  Val Val Ser 
    1070                 1075                 1080             


Gly Ser  Ser Ser Lys Ser Thr  Thr Leu Pro Arg Pro  Arg Pro Thr 
    1085                 1090                 1095             


Arg Thr  Ser Leu Leu Arg Arg  Ala Arg Leu Gly Glu  Ala Ser Asp 
    1100                 1105                 1110             


Ser Glu  Leu Ala Asp Ala Asp  Lys Ala Ser Val Ala  Ser Glu Val 
    1115                 1120                 1125             


Ser Thr  Thr Ser Ser Thr Ser  Lys Pro Pro Thr Gly  Arg Arg Asn 
    1130                 1135                 1140             


Ile Ser  Arg Ile Asp Leu Leu  Ala Gln Pro Arg Arg  Thr Arg Leu 
    1145                 1150                 1155             


Gly Ser  Leu Ser Ala Arg Ser  Asp Ser Glu Ala Thr  Ile Ser Arg 
    1160                 1165                 1170             


Ser Ser  Ala Ser Ser Arg Thr  Ala Glu Ala Ile Ile  Arg Ser Gly 
    1175                 1180                 1185             


Ala Arg  Leu Val Pro Ser Asp  Lys Phe Ser Pro Arg  Ile Arg Ala 
    1190                 1195                 1200             


Asn Ser  Ile Ser Arg Leu Ser  Asp Ser Lys Val Lys  Ser Met Thr 
    1205                 1210                 1215             


Ser Ala  His Gly Ser Ala Ser  Val Asn Ser Arg Trp  Arg Arg Phe 
    1220                 1225                 1230             


Pro Thr  Asp Tyr Ala Ser Thr  Ser Glu Asp Glu Phe  Gly Ser Asn 
    1235                 1240                 1245             


Arg Asn  Ser Pro Lys His Thr  Arg Leu Arg Thr Ser  Pro Ala Leu 
    1250                 1255                 1260             


Lys Thr  Thr Arg Leu Gln Ser  Ala Gly Ser Ala Met  Pro Thr Ser 
    1265                 1270                 1275             


Ser Ser  Phe Lys His Arg Ile  Lys Glu Gln Glu Asp  Tyr Ile Arg 
    1280                 1285                 1290             


Asp Trp  Thr Ala His Arg Glu  Glu Ile Ala Arg Ile  Ser Gln Asp 
    1295                 1300                 1305             


Leu Ala  Leu Ile Ala Arg Glu  Ile Asn Asp Val Ala  Gly Glu Ile 
    1310                 1315                 1320             


Asp Ser  Val Thr Ser Ser Gly  Thr Ala Pro Ser Thr  Thr Val Ser 
    1325                 1330                 1335             


Thr Ala  Ala Thr Thr Pro Gly  Ser Ala Ile Asp Thr  Arg Glu Glu 
    1340                 1345                 1350             


Leu Val  Asp Arg Val Phe Asp  Glu Ser Leu Asn Phe  Arg Lys Ile 
    1355                 1360                 1365             


Pro Pro  Leu Val His Ser Lys  Thr Pro Glu Gly Asn  Asn Gly Arg 
    1370                 1375                 1380             


Ser Gly  Asp Pro Arg Pro Gln  Ala Ala Glu Pro Pro  Asp His Leu 
    1385                 1390                 1395             


Thr Ile  Thr Arg Arg Arg Thr  Trp Ser Arg Asp Glu  Val Met Gly 
    1400                 1405                 1410             


Asp Asn  Leu Leu Leu Ser Ser  Val Phe Gln Phe Ser  Lys Lys Ile 
    1415                 1420                 1425             


Arg Gln  Ser Ile Asp Lys Thr  Ala Gly Lys Ile Arg  Ile Leu Phe 
    1430                 1435                 1440             


Lys Asp  Lys Asp Arg Asn Trp  Asp Asp Ile Glu Ser  Lys Leu Arg 
    1445                 1450                 1455             


Ala Glu  Ser Glu Val Pro Ile  Val Lys Thr Ser Ser  Met Glu Ile 
    1460                 1465                 1470             


Ser Ser  Ile Leu Gln Glu Leu  Lys Arg Val Glu Lys  Gln Leu Gln 
    1475                 1480                 1485             


Ala Ile  Asn Ala Met Ile Asp  Pro Asp Gly Thr Leu  Glu Ala Leu 
    1490                 1495                 1500             


Asn Asn  Met Gly Phe Pro Ser  Ala Met Leu Pro Ser  Pro Pro Lys 
    1505                 1510                 1515             


Gln Lys  Ser Ser Pro Val Asn  Asn His His Ser Pro  Gly Gln Thr 
    1520                 1525                 1530             


Pro Thr  Leu Gly Gln Pro Glu  Ala Arg Ala Leu His  Pro Ala Ala 
    1535                 1540                 1545             


Val Ser  Ala Ala Ala Glu Phe  Glu Asn Ala Glu Ser  Glu Ala Asp 
    1550                 1555                 1560             


Phe Ser  Ile His Phe Asn Arg  Phe Asn Pro Asp Gly  Glu Glu Glu 
    1565                 1570                 1575             


Asp Val  Thr Val Gln Glu 
    1580                 


<210>  653
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  653

Met Ala Leu Gly Glu Glu Lys Ala Glu Ala Glu Ala Ser Glu Asp Thr 
1               5                   10                  15      


Lys Ala Gln Ser Tyr Gly Arg Gly Ser Cys Arg Glu Arg Glu Leu Asp 
            20                  25                  30          


Ile Pro Gly Pro Met Ser Gly Glu Gln Pro Pro Arg Leu Glu Ala Glu 
        35                  40                  45              


Gly Gly Leu Ile Ser Pro Val Trp Gly Ala Glu Gly Ile Pro Ala Pro 
    50                  55                  60                  


Thr Cys Trp Ile Gly Thr Asp Pro Gly Gly Pro Ser Arg Ala His Gln 
65                  70                  75                  80  


Pro Gln Ala Ser Asp Ala Asn Arg Glu Pro Val Ala Glu Arg Ser Glu 
                85                  90                  95      


Pro Ala Leu Ser Gly Leu Pro Pro Ala Thr Met Gly Ser Gly Asp Leu 
            100                 105                 110         


Leu Leu Ser Gly Glu Ser Gln Val Glu Lys Thr Lys Leu Ser Ser Ser 
        115                 120                 125             


Glu Glu Phe Pro Gln Thr Leu Ser Leu Pro Arg Thr Thr Thr Ile Cys 
    130                 135                 140                 


Ser Gly His Asp Ala Asp Thr Glu Asp Asp Pro Ser Leu Ala Asp Leu 
145                 150                 155                 160 


Pro Gln Ala Leu Asp Leu Ser Gln Gln Pro His Ser Ser Gly Leu Ser 
                165                 170                 175     


Cys Leu Ser Gln Trp Lys Ser Val Leu Ser Pro Gly Ser Ala Ala Gln 
            180                 185                 190         


Pro Ser Ser Cys Ser Ile Ser Ala Ser Ser Thr Gly Ser Ser Leu Gln 
        195                 200                 205             


Gly His Gln Glu Arg Ala Glu Pro Arg Gly Gly Ser Leu Ala Lys Val 
    210                 215                 220                 


Ser Ser Ser Leu Glu Pro Val Val Pro Gln Glu Pro Ser Ser Val Val 
225                 230                 235                 240 


Gly Leu Gly Pro Arg Pro Gln Trp Ser Pro Gln Pro Val Phe Ser Gly 
                245                 250                 255     


Gly Asp Ala Ser Gly Leu Gly Arg Arg Arg Leu Ser Phe Gln Ala Glu 
            260                 265                 270         


Tyr Trp Ala Cys Val Leu Pro Asp Ser Leu Pro Pro Ser Pro Asp Arg 
        275                 280                 285             


His Ser Pro Leu Trp Asn Pro Asn Lys Glu Tyr Glu Asp Leu Leu Asp 
    290                 295                 300                 


Tyr Thr Tyr Pro Leu Arg Pro Gly Pro Gln Leu Pro Lys His Leu Asp 
305                 310                 315                 320 


Ser Arg Val Pro Ala Asp Pro Val Leu Gln Asp Ser Gly Val Asp Leu 
                325                 330                 335     


Asp Ser Phe Ser Val Ser Pro Ala Ser Thr Leu Lys Ser Pro Thr Asn 
            340                 345                 350         


Val Ser Pro Asn Cys Pro Pro Ala Glu Ala Thr Ala Leu Pro Phe Ser 
        355                 360                 365             


Gly Pro Arg Glu Pro Ser Leu Lys Gln Trp Pro Ser Arg Val Pro Gln 
    370                 375                 380                 


Lys Gln Gly Gly Met Gly Leu Ala Ser Trp Ser Gln Leu Ala Ser Thr 
385                 390                 395                 400 


Pro Arg Ala Pro Gly Ser Arg Asp Ala Arg Trp Glu Arg Arg Glu Pro 
                405                 410                 415     


Ala Leu Arg Gly Ala Lys Asp Arg Leu Thr Ile Gly Lys His Leu Asp 
            420                 425                 430         


Met Gly Ser Pro Gln Leu Arg Thr Arg Asp Arg Gly Trp Pro Ser Pro 
        435                 440                 445             


Arg Pro Glu Arg Glu Lys Arg Thr Ser Gln Ser Ala Arg Arg Pro Thr 
    450                 455                 460                 


Cys Thr Glu Ser Arg Trp Lys Ser Glu Glu Glu Val Glu Ser Asp Asp 
465                 470                 475                 480 


Glu Tyr Leu Ala Leu Pro Ala Arg Leu Thr Gln Val Ser Ser Leu Val 
                485                 490                 495     


Ser Tyr Leu Gly Ser Ile Ser Thr Leu Val Thr Leu Pro Thr Gly Asp 
            500                 505                 510         


Ile Lys Gly Gln Ser Pro Leu Glu Val Ser Asp Ser Asp Gly Pro Ala 
        515                 520                 525             


Ser Phe Pro Ser Ser Ser Ser Gln Ser Gln Leu Pro Pro Gly Ala Ala 
    530                 535                 540                 


Leu Gln Gly Ser Gly Asp Pro Glu Gly Gln Asn Pro Cys Phe Leu Arg 
545                 550                 555                 560 


Ser Phe Val Arg Ala His Asp Ser Ala Gly Glu Gly Ser Leu Gly Ser 
                565                 570                 575     


Ser Gln Ala Leu Gly Val Ser Ser Gly Leu Leu Lys Thr Arg Pro Ser 
            580                 585                 590         


Leu Pro Ala Arg Leu Asp Arg Trp Pro Phe Ser Asp Pro Asp Val Glu 
        595                 600                 605             


Gly Gln Leu Pro Arg Lys Gly Gly Glu Gln Gly Lys Glu Ser Leu Val 
    610                 615                 620                 


Gln Cys Val Lys Thr Phe Cys Cys Gln Leu Glu Glu Leu Ile Cys Trp 
625                 630                 635                 640 


Leu Tyr Asn Val Ala Asp Val Thr Asp His Gly Thr Ala Ala Arg Ser 
                645                 650                 655     


Asn Leu Thr Ser Leu Lys Ser Ser Leu Gln Leu Tyr Arg Gln Phe Lys 
            660                 665                 670         


Lys Asp Ile Asp Glu His Gln Ser Leu Thr Glu Ser Val Leu Gln Lys 
        675                 680                 685             


Gly Glu Ile Leu Leu Gln Cys Leu Leu Glu Asn Thr Pro Val Leu Glu 
    690                 695                 700                 


Asp Val Leu Gly Arg Ile Ala Lys Gln Ser Gly Glu Leu Glu Ser His 
705                 710                 715                 720 


Ala Asp Arg Leu Tyr Asp Ser Ile Leu Ala Ser Leu Asp Met Leu Ala 
                725                 730                 735     


Gly Cys Thr Leu Ile Pro Asp Lys Lys Pro Met Ala Ala Met Glu His 
            740                 745                 750         


Pro Cys Glu Gly Val 
        755         


<210>  654
<211>  1966
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Lys Ala Ala Asp Thr Val Ile Leu Trp Ala Arg Ser Lys Asn Asp 
1               5                   10                  15      


Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met 
            20                  25                  30          


Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys 
        35                  40                  45              


Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys 
    50                  55                  60                  


Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu 
65                  70                  75                  80  


Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly 
                85                  90                  95      


Thr Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu 
            100                 105                 110         


Lys Lys Thr Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys 
        115                 120                 125             


Gln Val Glu Gln Lys Ser Ser Ala Thr Leu Leu Leu Thr Trp Gly Leu 
    130                 135                 140                 


Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Thr Leu Thr 
145                 150                 155                 160 


Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys 
                165                 170                 175     


Asn Pro Lys Ile Pro Met Ser Lys Met Met Thr Ile Leu Gly Ala Lys 
            180                 185                 190         


Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val 
    210                 215                 220                 


Ser Ala Ala Val Ser Ser Ala Thr Pro Ile Ala Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg 
                245                 250                 255     


Arg Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser 
            260                 265                 270         


Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
        275                 280                 285             


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
    290                 295                 300                 


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
305                 310                 315                 320 


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
                325                 330                 335     


Arg Pro Asp Gly Pro Val Arg Thr Lys Lys Leu Lys Arg Gly Arg Pro 
            340                 345                 350         


Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu 
        355                 360                 365             


Glu Glu Val Asp Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val 
    370                 375                 380                 


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala 
385                 390                 395                 400 


Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly 
                405                 410                 415     


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala 
            420                 425                 430         


Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        435                 440                 445             


Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp 
    450                 455                 460                 


Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile 
465                 470                 475                 480 


His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu 
                485                 490                 495     


Cys Pro Arg Cys Thr Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile 
            500                 505                 510         


Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln 
        515                 520                 525             


Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly 
    530                 535                 540                 


Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp 
545                 550                 555                 560 


His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val 
                565                 570                 575     


Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro 
            580                 585                 590         


Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys 
        595                 600                 605             


Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe 
    610                 615                 620                 


Gly Ile Lys Pro Glu Trp Met Thr Val His Arg Ile Ile Asn His Ser 
625                 630                 635                 640 


Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu 
                645                 650                 655     


Pro Tyr Asp Gln Ser Thr Trp Glu Glu Asp Glu Met Asn Ile Pro Glu 
            660                 665                 670         


Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met 
        675                 680                 685             


Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu 
    690                 695                 700                 


Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Thr Asn Asp Pro Thr Val 
705                 710                 715                 720 


Lys Tyr Glu Thr Gln Pro Arg Phe Ile Thr Ala Thr Gly Gly Thr Leu 
                725                 730                 735     


His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala 
            740                 745                 750         


Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr 
        755                 760                 765             


Ile Gln Thr Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Thr 
    770                 775                 780                 


Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp 
785                 790                 795                 800 


Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Thr Tyr 
                805                 810                 815     


Thr Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser 
            820                 825                 830         


Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys 
        835                 840                 845             


Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu 
    850                 855                 860                 


Ile Thr Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu 
865                 870                 875                 880 


Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe 
                885                 890                 895     


Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Thr Gly 
            900                 905                 910         


Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe 
        915                 920                 925             


Leu Thr Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe 
    930                 935                 940                 


Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu 
945                 950                 955                 960 


Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met 
                965                 970                 975     


Pro Ala Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln 
            980                 985                 990         


Lys Lys Tyr Tyr Lys Tyr Ile Leu  Thr Arg Asn Phe Glu  Ala Leu Asn 
        995                 1000                 1005             


Ser Arg  Gly Gly Gly Asn Gln  Val Ser Leu Leu Asn  Ile Met Met 
    1010                 1015                 1020             


Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr Leu Phe  Pro Val Ala 
    1025                 1030                 1035             


Ala Met  Glu Ser Pro Lys Leu  Pro Ser Gly Ala Tyr  Glu Gly Gly 
    1040                 1045                 1050             


Ala Leu  Ile Lys Ser Ser Gly  Lys Leu Met Leu Leu  Gln Lys Met 
    1055                 1060                 1065             


Leu Arg  Lys Leu Lys Glu Gln  Gly His Arg Val Leu  Ile Phe Ser 
    1070                 1075                 1080             


Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu Asp Phe  Leu Asp Tyr 
    1085                 1090                 1095             


Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly Gly Ile  Thr Gly Ala 
    1100                 1105                 1110             


Leu Arg  Gln Glu Ala Ile Asp  Arg Phe Asn Ala Pro  Gly Ala Gln 
    1115                 1120                 1125             


Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala Gly Gly  Leu Gly Ile 
    1130                 1135                 1140             


Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile Phe Asp  Ser Asp Trp 
    1145                 1150                 1155             


Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser Arg Ala  His Arg Ile 
    1160                 1165                 1170             


Gly Gln  Ala Asn Lys Val Met  Ile Tyr Arg Phe Val  Thr Arg Ala 
    1175                 1180                 1185             


Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala Lys Arg  Lys Met Met 
    1190                 1195                 1200             


Leu Thr  His Leu Val Val Arg  Pro Gly Leu Gly Ser  Lys Ala Gly 
    1205                 1210                 1215             


Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile Leu Lys  Phe Gly Thr 
    1220                 1225                 1230             


Glu Glu  Leu Phe Lys Asp Glu  Asn Glu Gly Glu Asn  Lys Glu Glu 
    1235                 1240                 1245             


Asp Ser  Ser Val Ile His Tyr  Asp Asn Glu Ala Ile  Ala Arg Leu 
    1250                 1255                 1260             


Leu Asp  Arg Asn Gln Asp Ala  Thr Glu Asp Thr Asp  Val Gln Asn 
    1265                 1270                 1275             


Met Asn  Glu Tyr Leu Ser Ser  Phe Lys Val Ala Gln  Tyr Val Val 
    1280                 1285                 1290             


Arg Glu  Glu Asp Lys Ile Glu  Glu Ile Glu Arg Glu  Ile Ile Lys 
    1295                 1300                 1305             


Gln Glu  Glu Asn Val Asp Pro  Asp Tyr Trp Glu Lys  Leu Leu Arg 
    1310                 1315                 1320             


His His  Tyr Glu Gln Gln Gln  Glu Asp Leu Ala Arg  Asn Leu Gly 
    1325                 1330                 1335             


Lys Gly  Lys Arg Val Arg Lys  Gln Val Asn Tyr Asn  Asp Ala Ala 
    1340                 1345                 1350             


Gln Glu  Asp Gln Asp Asn Gln  Ser Glu Tyr Ser Val  Gly Ser Glu 
    1355                 1360                 1365             


Glu Glu  Asp Glu Asp Phe Asp  Glu Arg Pro Glu Gly  Arg Arg Gln 
    1370                 1375                 1380             


Ser Lys  Arg Gln Leu Arg Asn  Glu Lys Asp Lys Pro  Leu Pro Pro 
    1385                 1390                 1395             


Leu Leu  Ala Arg Val Gly Gly  Asn Ile Glu Val Leu  Gly Phe Asn 
    1400                 1405                 1410             


Thr Arg  Gln Arg Lys Ala Phe  Leu Asn Ala Val Met  Arg Trp Gly 
    1415                 1420                 1425             


Met Pro  Pro Gln Asp Ala Phe  Thr Thr Gln Trp Leu  Val Arg Asp 
    1430                 1435                 1440             


Leu Arg  Gly Lys Thr Glu Lys  Glu Phe Lys Ala Tyr  Val Ser Leu 
    1445                 1450                 1455             


Phe Met  Arg His Leu Cys Glu  Pro Gly Ala Asp Gly  Ser Glu Thr 
    1460                 1465                 1470             


Phe Ala  Asp Gly Val Pro Arg  Glu Gly Leu Ser Arg  Gln Gln Val 
    1475                 1480                 1485             


Leu Thr  Arg Ile Gly Val Met  Ser Leu Val Lys Lys  Lys Val Gln 
    1490                 1495                 1500             


Glu Phe  Glu His Ile Asn Gly  Arg Trp Ser Met Pro  Glu Leu Met 
    1505                 1510                 1515             


Pro Asp  Pro Ser Ala Asp Ser  Lys Arg Ser Ser Arg  Ala Ser Ser 
    1520                 1525                 1530             


Pro Thr  Lys Thr Ser Pro Thr  Thr Pro Glu Ala Ser  Ala Thr Asn 
    1535                 1540                 1545             


Ser Pro  Cys Thr Ser Lys Pro  Ala Thr Pro Ala Pro  Ser Glu Lys 
    1550                 1555                 1560             


Gly Glu  Gly Ile Arg Thr Pro  Leu Glu Lys Glu Glu  Ala Glu Asn 
    1565                 1570                 1575             


Gln Glu  Glu Lys Pro Glu Lys  Asn Ser Arg Ile Gly  Glu Lys Met 
    1580                 1585                 1590             


Glu Thr  Glu Ala Asp Ala Pro  Ser Pro Ala Pro Ser  Leu Gly Glu 
    1595                 1600                 1605             


Arg Leu  Glu Pro Arg Lys Ile  Pro Leu Glu Asp Glu  Val Pro Gly 
    1610                 1615                 1620             


Val Pro  Gly Glu Met Glu Pro  Glu Pro Gly Tyr Arg  Gly Asp Arg 
    1625                 1630                 1635             


Glu Lys  Ser Glu Asp Val Lys  Gly Asp Arg Glu Leu  Arg Pro Gly 
    1640                 1645                 1650             


Pro Arg  Asp Glu Pro Arg Ser  Asn Gly Arg Arg Glu  Glu Lys Thr 
    1655                 1660                 1665             


Glu Lys  Pro Arg Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Thr 
    1670                 1675                 1680             


Glu Leu  His Thr Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Ile Ser 
    1685                 1690                 1695             


Ser Gly  Lys Leu Asn Glu Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1700                 1705                 1710             


Leu Leu  Ala Gly Ile Val Leu  His Gly Tyr Ala Arg  Trp Gln Asp 
    1715                 1720                 1725             


Ile Gln  Asn Asp Ala Gln Phe  Ala Ile Ile Asn Glu  Pro Phe Lys 
    1730                 1735                 1740             


Thr Glu  Ala Asn Lys Gly Asn  Phe Leu Glu Met Lys  Asn Lys Phe 
    1745                 1750                 1755             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1760                 1765                 1770             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Leu Ser  Gln Glu Pro 
    1775                 1780                 1785             


Ala His  Pro Ala Met Ala Leu  His Ala Arg Phe Ala  Glu Ala Glu 
    1790                 1795                 1800             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1805                 1810                 1815             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1820                 1825                 1830             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Thr Arg Leu 
    1835                 1840                 1845             


Pro Ala  Thr Leu Ser Arg Ile  Pro Pro Ile Ala Ala  Arg Leu Gln 
    1850                 1855                 1860             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Ala Ser  Lys Gly Thr 
    1865                 1870                 1875             


Glu Pro  His Pro Thr Pro Ala  Tyr Pro Pro Gly Pro  Tyr Ala Thr 
    1880                 1885                 1890             


Pro Pro  Gly Tyr Gly Ala Ala  Phe Ser Ala Ala Pro  Val Gly Ala 
    1895                 1900                 1905             


Leu Ala  Ala Ala Gly Ala Asn  Tyr Ser Gln Met Pro  Ala Gly Ser 
    1910                 1915                 1920             


Phe Ile  Thr Ala Ala Thr Asn  Gly Pro Pro Val Leu  Val Lys Lys 
    1925                 1930                 1935             


Glu Lys  Glu Met Val Gly Ala  Leu Val Ser Asp Gly  Leu Asp Arg 
    1940                 1945                 1950             


Lys Glu  Pro Arg Ala Gly Glu  Val Ile Cys Ile Asp  Asp 
    1955                 1960                 1965     


<210>  655
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  655

Met Ser Asn Met Glu Lys His Leu Phe Asn Leu Lys Phe Ala Ala Lys 
1               5                   10                  15      


Glu Leu Ser Arg Ser Ala Lys Lys Cys Asp Lys Glu Glu Lys Ala Glu 
            20                  25                  30          


Lys Ala Lys Ile Lys Lys Ala Ile Gln Lys Gly Asn Met Glu Val Ala 
        35                  40                  45              


Arg Ile His Ala Glu Asn Ala Ile Arg Gln Lys Asn Gln Ala Val Asn 
    50                  55                  60                  


Phe Leu Arg Met Ser Ala Arg Val Asp Ala Val Ala Ala Arg Val Gln 
65                  70                  75                  80  


Thr Ala Val Thr Met Gly Lys Val Thr Lys Ser Met Ala Gly Val Val 
                85                  90                  95      


Lys Ser Met Asp Ala Thr Leu Lys Thr Met Asn Leu Glu Lys Ile Ser 
            100                 105                 110         


Ala Leu Met Asp Lys Phe Glu His Gln Phe Glu Thr Leu Asp Val Gln 
        115                 120                 125             


Thr Gln Gln Met Glu Asp Thr Met Ser Ser Thr Thr Thr Leu Thr Thr 
    130                 135                 140                 


Pro Gln Asn Gln Val Asp Met Leu Leu Gln Glu Met Ala Asp Glu Ala 
145                 150                 155                 160 


Gly Leu Asp Leu Asn Met Glu Leu Pro Gln Gly Gln Thr Gly Ser Val 
                165                 170                 175     


Gly Thr Ser Val Ala Ser Ala Glu Gln Asp Glu Leu Ser Gln Arg Leu 
            180                 185                 190         


Ala Arg Leu Arg Asp Gln Val 
        195                 


<210>  656
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Trp Ser Pro Glu Arg Glu Ala Glu Ala Pro Ala Gly Gly Asp Pro 
1               5                   10                  15      


Ala Gly Leu Leu Pro Pro Glu Trp Glu Glu Asp Glu Glu Arg Met Ser 
            20                  25                  30          


Phe Leu Phe Ser Ala Phe Lys Arg Ser Arg Glu Val Asn Ser Thr Asp 
        35                  40                  45              


Trp Asp Ser Lys Met Gly Phe Trp Ala Pro Leu Val Leu Ser His Ser 
    50                  55                  60                  


Arg Arg Gln Gly Val Val Arg Leu Arg Leu Arg Asp Leu Gln Glu Ala 
65                  70                  75                  80  


Phe Gln Arg Lys Gly Ser Val Pro Leu Gly Leu Ala Thr Val Leu Gln 
                85                  90                  95      


Asp Leu Leu Arg Arg Gly Glu Leu Gln Arg Glu Ser Asp Phe Met Ala 
            100                 105                 110         


Ser Val Asp Ser Ser Trp Ile Ser Trp Gly Val Gly Val Phe Leu Leu 
        115                 120                 125             


Lys Pro Leu Lys Trp Thr Leu Ser Asn Met Leu Gly Asp Asn Lys Val 
    130                 135                 140                 


Pro Ala Glu Glu Val Leu Val Ala Val Glu Leu Leu Lys Glu Lys Ala 
145                 150                 155                 160 


Glu Glu Val Tyr Arg Leu Tyr Gln Asn Ser Pro Leu Ser Ser His Pro 
                165                 170                 175     


Val Val Ala Leu Ser Glu Leu Ser Thr Leu Cys Ala Asn Ser Cys Pro 
            180                 185                 190         


Asp Glu Arg Thr Phe Tyr Leu Val Leu Leu Gln Leu Gln Lys Glu Lys 
        195                 200                 205             


Arg Val Thr Val Leu Glu Gln Asn Gly Glu Lys Ile Val Lys Phe Ala 
    210                 215                 220                 


Arg Gly Pro Arg Ala Lys Val Ser Pro Val Asn Asp Val Asp Val Gly 
225                 230                 235                 240 


Val Tyr Gln Leu Met Gln Ser Glu Gln Leu Leu Ser Arg Lys Val Glu 
                245                 250                 255     


Ser Leu Ser Gln Glu Ala Glu Arg Cys Lys Glu Glu Ala Arg Arg Ala 
            260                 265                 270         


Cys Arg Ala Gly Lys Lys Gln Leu Ala Leu Arg Ser Leu Lys Ala Lys 
        275                 280                 285             


Gln Arg Thr Glu Lys Arg Ile Glu Ala Leu His Ala Lys Leu Asp Thr 
    290                 295                 300                 


Val Gln Gly Ile Leu Asp Arg Ile Tyr Ala Ser Gln Thr Asp Gln Met 
305                 310                 315                 320 


Val Phe Asn Ala Tyr Gln Ala Gly Val Gly Ala Leu Lys Leu Ser Met 
                325                 330                 335     


Lys Asp Val Thr Val Glu Lys Ala Glu Ser Leu Val Asp Gln Ile Gln 
            340                 345                 350         


Glu Leu Cys Asp Thr Gln Asp Glu Val Ser Gln Thr Leu Ala Gly Gly 
        355                 360                 365             


Val Thr Asn Gly Leu Asp Phe Asp Ser Glu Glu Leu Glu Lys Glu Leu 
    370                 375                 380                 


Asp Ile Leu Leu Gln Asp Thr Thr Lys Glu Pro Leu Asp Leu Pro Asp 
385                 390                 395                 400 


Asn Pro Arg Asn Arg His Phe Thr Asn Ser Val Pro Asn Pro Arg Ile 
                405                 410                 415     


Ser Asp Ala Glu Leu Glu Ala Glu Leu Glu Lys Leu Ser Leu Ser Glu 
            420                 425                 430         


Gly Gly Leu Val Pro Ser Ser Lys Ser Pro Lys Arg Gln Leu Glu Pro 
        435                 440                 445             


Thr Leu Lys Pro Leu 
    450             


<210>  657
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  657

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Leu Glu Leu Ser Asn Thr Ala Val Leu His Gln Met 
65                  70                  75                  80  


Arg Arg Asp Gln Val Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser 
                85                  90                  95      


Arg Lys Arg Arg Val Leu Thr Pro Asn Asp Leu Lys His Leu Val Val 
            100                 105                 110         


Asp Glu Asp His Glu Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys 
        115                 120                 125             


Thr Asn Trp Lys Arg Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr 
    130                 135                 140                 


Ser Asp Pro Met Glu Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn 
145                 150                 155                 160 


Leu Lys Thr Leu Asn Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu 
                165                 170                 175     


Lys Ser Tyr Met Lys Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu 
            180                 185                 190         


Val Ser Ala Tyr Arg Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe 
        195                 200                 205             


His Lys Arg Tyr Gly Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala 
    210                 215                 220                 


Thr Gln Glu Ala Leu Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe 
225                 230                 235                 240 


Val Ala Tyr Leu Ile Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn 
                245                 250                 255     


Glu His Trp Gln Thr Val Tyr Ser Leu Cys His Pro Cys His Ile His 
            260                 265                 270         


Tyr Asp Leu Val Gly Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr 
        275                 280                 285             


Val Leu Gln Leu Ala Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr 
    290                 295                 300                 


Ala Lys Ser Thr Arg Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln 
305                 310                 315                 320 


Asn Ile Ser Ser Glu His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu 
                325                 330                 335     


Asp Phe Leu Met Phe Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345                 350         


<210>  658
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp 
1               5                   10                  15      


Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu 
            20                  25                  30          


Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys 
        35                  40                  45              


Gln Leu Leu Gln Ser Ala His Lys Glu Ser Ser Phe Asp Ile Ile Leu 
    50                  55                  60                  


Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu Ile Leu 
65                  70                  75                  80  


Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys 
                85                  90                  95      


Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala 
            100                 105                 110         


Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys 
        115                 120                 125             


Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln Ser Val Arg 
    130                 135                 140                 


Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gln Ile Thr 
145                 150                 155                 160 


Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln Leu Lys Leu 
                165                 170                 175     


Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro 
            180                 185                 190         


Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp 
        195                 200                 205             


Ser Met Asp Leu Ile Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu 
    210                 215                 220                 


Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly 
225                 230                 235                 240 


Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu 
                245                 250                 255     


Leu Glu Lys Glu Lys Ser Arg Glu Gln Met Ser Ser Gln Pro Lys Ser 
            260                 265                 270         


Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys 
        275                 280                 285             


Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu 
    290                 295                 300                 


Ser Asp Ser Asn Leu His Asp Ala 
305                 310         


<210>  659
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  659

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Thr Ala Pro His Lys Ser Asn Thr Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Ile Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys Thr 
65                  70                  75                  80  


Thr Lys Glu Leu Val His Thr Thr Leu Glu Cys Val Lys Lys Asn Met 
                85                  90                  95      


Pro Val Glu Glu Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser 
            100                 105                 110         


Phe Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp Gln 
        115                 120                 125             


Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile 
    130                 135                 140                 


Asn Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu 
145                 150                 155                 160 


Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp 
                165                 170                 175     


Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp His 
            180                 185                 190         


Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe 
        195                 200                 205             


Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly 
    210                 215                 220                 


Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
225                 230                 235         


<210>  660
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Arg His Ser Lys Arg Thr His Cys Pro Asp Trp Asp Ser Arg Glu 
1               5                   10                  15      


Ser Trp Gly His Glu Ser Tyr Arg Gly Ser His Lys Arg Lys Arg Arg 
            20                  25                  30          


Ser His Ser Ser Thr Gln Glu Asn Arg His Cys Lys Pro His His Gln 
        35                  40                  45              


Phe Lys Glu Ser Asp Cys His Tyr Leu Glu Ala Arg Ser Leu Asn Glu 
    50                  55                  60                  


Arg Asp Tyr Arg Asp Arg Arg Tyr Val Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Cys Glu Gly Tyr Val Pro Arg His Tyr His Arg Asp Ile Glu Ser Gly 
                85                  90                  95      


Tyr Arg Ile His Cys Ser Lys Ser Ser Val Arg Ser Arg Arg Ser Ser 
            100                 105                 110         


Pro Lys Arg Lys Arg Asn Arg His Cys Ser Ser His Gln Ser Arg Ser 
        115                 120                 125             


Lys Ser His Arg Arg Lys Arg Ser Arg Ser Ile Glu Asp Asp Glu Glu 
    130                 135                 140                 


Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Arg Ala Arg Tyr Glu 
145                 150                 155                 160 


Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val Glu Cys 
                165                 170                 175     


Ile Asp His Gly Met Asp Gly Met His Val Ala Val Lys Ile Val Lys 
            180                 185                 190         


Asn Val Gly Arg Tyr Arg Glu Ala Ala Arg Ser Glu Ile Gln Val Leu 
        195                 200                 205             


Glu His Leu Asn Ser Thr Asp Pro Asn Ser Val Phe Arg Cys Val Gln 
    210                 215                 220                 


Met Leu Glu Trp Phe Asp His His Gly His Val Cys Ile Val Phe Glu 
225                 230                 235                 240 


Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Ser Phe Leu 
                245                 250                 255     


Pro Phe Gln Ile Asp His Ile Arg Gln Met Ala Tyr Gln Ile Cys Gln 
            260                 265                 270         


Ser Ile Asn Phe Leu His His Asn Lys Leu Thr His Thr Asp Leu Lys 
        275                 280                 285             


Pro Glu Asn Ile Leu Phe Val Lys Ser Asp Tyr Val Val Lys Tyr Asn 
    290                 295                 300                 


Ser Lys Met Lys Arg Asp Glu Arg Thr Leu Lys Asn Thr Asp Ile Lys 
305                 310                 315                 320 


Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His Ser Thr 
                325                 330                 335     


Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu Ala Leu 
            340                 345                 350         


Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu Ile 
        355                 360                 365             


Glu Tyr Tyr Leu Gly Phe Thr Val Phe Gln Thr His Asp Ser Lys Glu 
    370                 375                 380                 


His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile Pro Gln His Met 
385                 390                 395                 400 


Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asn Gln Leu Asp 
                405                 410                 415     


Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Arg Arg Arg Cys Lys 
            420                 425                 430         


Pro Leu Lys Glu Phe Met Leu Cys His Asp Glu Glu His Glu Lys Leu 
        435                 440                 445             


Phe Asp Leu Val Arg Arg Met Leu Glu Tyr Asp Pro Thr Gln Arg Ile 
    450                 455                 460                 


Thr Leu Asp Glu Ala Leu Gln His Pro Phe Phe Asp Leu Leu Lys Lys 
465                 470                 475                 480 


Lys 
    


<210>  661
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  661

Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Thr Gly Lys Thr Lys Glu Val Ile Gly Thr Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Thr Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Thr Glu Thr Ile Cys Lys Arg Leu Leu Asp Tyr Ser Leu 
            100                 105                 110         


His Lys Glu Arg Thr Gly Ser Asn Arg Phe Ala Lys Gly Met Ser Glu 
        115                 120                 125             


Thr Phe Glu Thr Leu His Asn Leu Val His Lys Gly Val Lys Val Val 
    130                 135                 140                 


Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Thr Ser Ala Glu Val Ala 
145                 150                 155                 160 


Asp Leu Lys Lys Gln Cys Asp Val Leu Val Glu Glu Phe Glu Glu Val 
                165                 170                 175     


Ile Glu Asp Trp Tyr Arg Asn His Gln Glu Glu Asp Leu Thr Glu Phe 
            180                 185                 190         


Leu Cys Ala Asn His Val Leu Lys Gly Lys Asp Thr Ser Cys Leu Ala 
        195                 200                 205             


Glu Gln Trp Ser Gly Lys Lys Gly Asp Thr Ala Ala Leu Gly Gly Lys 
    210                 215                 220                 


Lys Ser Lys Lys Lys Ser Ser Arg Ala Lys Ala Ala Gly Gly Arg Ser 
225                 230                 235                 240 


Ser Ser Ser Lys Gln Arg Lys Glu Leu Gly Gly Leu Glu Gly Asp Pro 
                245                 250                 255     


Ser Pro Glu Glu Asp Glu Gly Ile Gln Lys Ala Ser Pro Leu Thr His 
            260                 265                 270         


Ser Pro Pro Asp Glu Leu 
        275             


<210>  662
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Thr Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Thr Glu Ala Glu Asn Gln Gln Met Thr Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Thr Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Thr Ser 
        35                  40                  45              


Ser Ala Pro Thr Val Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Thr Val Gln Ile Ser Thr Ile Ala Glu Ser Glu Asp 
                85                  90                  95      


Ser Gln Glu Ser Val Asp Ser Val Thr Asp Ser Gln Lys Arg Arg Glu 
            100                 105                 110         


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser 
        115                 120                 125             


Ser Asp Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu 
    130                 135                 140                 


Glu Thr Ser Ala Pro Ala Ile Thr Thr Val Thr Val Pro Thr Pro Ile 
145                 150                 155                 160 


Tyr Gln Thr Ser Ser Gly Gln Tyr Ile Ala Ile Thr Gln Gly Gly Ala 
                165                 170                 175     


Ile Gln Leu Ala Asn Asn Gly Thr Asp Gly Val Gln Gly Leu Gln Thr 
            180                 185                 190         


Leu Thr Met Thr Asn Ala Ala Ala Thr Gln Pro Gly Thr Thr Ile Leu 
        195                 200                 205             


Gln Tyr Ala Gln Thr Thr Asp Gly Gln Gln Ile Leu Val Pro Ser Asn 
    210                 215                 220                 


Gln Val Val Val Gln Ala Ala Ser Gly Asp Val Gln Thr Tyr Gln Ile 
225                 230                 235                 240 


Arg Thr Ala Pro Thr Ser Thr Ile Ala Pro Gly Val Val Met Ala Ser 
                245                 250                 255     


Ser Pro Ala Leu Pro Thr Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg 
            260                 265                 270         


Glu Val Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg 
        275                 280                 285             


Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu 
    290                 295                 300                 


Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp 
305                 310                 315                 320 


Leu Tyr Cys His Lys Ser Asp 
                325         


<210>  663
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  663

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  664
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Arg Gly Ala Met Glu Leu Glu Pro Glu Leu Leu Leu Gln Glu Ala 
1               5                   10                  15      


Arg Glu Asn Val Glu Ala Ala Gln Ser Tyr Arg Arg Glu Leu Gly His 
            20                  25                  30          


Arg Leu Glu Gly Leu Arg Glu Ala Arg Arg Gln Ile Lys Glu Ser Ala 
        35                  40                  45              


Ser Gln Thr Arg Asp Val Leu Lys Gln His Phe Asn Asp Leu Lys Gly 
    50                  55                  60                  


Thr Leu Gly Lys Leu Leu Asp Glu Arg Leu Val Thr Leu Leu Gln Glu 
65                  70                  75                  80  


Val Asp Thr Ile Glu Gln Glu Thr Ile Lys Pro Leu Asp Asp Cys Gln 
                85                  90                  95      


Lys Leu Ile Glu His Gly Val Asn Thr Ala Glu Asp Leu Val Arg Glu 
            100                 105                 110         


Gly Glu Ile Ala Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu 
        115                 120                 125             


Trp Ser Phe Thr Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro 
    130                 135                 140                 


Glu Val Pro Leu Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp 
145                 150                 155                 160 


Asp Ser Ile Leu Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr 
                165                 170                 175     


Val Ala Ser Arg Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro 
            180                 185                 190         


Gly Gly Ile Ile Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala 
        195                 200                 205             


Gln Asp Tyr Arg Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu 
    210                 215                 220                 


Asp Val Tyr Val Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp 
225                 230                 235                 240 


Pro Asn Val Asp Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg 
                245                 250                 255     


Gln Glu Trp Ser Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu 
            260                 265                 270         


Val Pro His Glu Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser 
        275                 280                 285             


Arg Arg Asn Ile Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu 
    290                 295                 300                 


Tyr Ser Arg Ala Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg 
305                 310                 315                 320 


Val Glu Thr Val Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys 
                325                 330                 335     


Ala Glu Lys Gln Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val 
            340                 345                 350         


Cys Ile Ser Thr Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr 
        355                 360                 365             


Asn Gln Leu Pro Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile 
    370                 375                 380                 


Glu Ala Val Thr Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe 
385                 390                 395                 400 


Lys Leu Arg Val Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp 
                405                 410                 415     


Trp Leu Leu Asp Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe 
            420                 425                 430         


Phe Tyr Pro Gly Trp Lys Val Leu Val Phe 
        435                 440         


<210>  665
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  665

Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Thr Gln Arg Gln Ala Glu Glu Thr Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Thr Asp Leu Thr Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Thr Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Thr Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Thr Ser Ala Leu Asn Arg Thr 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Thr Ser Ala Leu Ser Thr Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Thr Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Thr Leu Asn Thr Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Thr Asn Leu His Tyr Ser Thr Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Thr Thr Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Thr His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Thr 
                325                 330                 335     


Leu Asn Lys Thr Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Thr 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Thr Thr Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Thr Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Thr Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Thr Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Thr Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Thr Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Thr Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Thr Ile Leu Pro Glu Asp Ser Ser Thr Ser Leu Phe Lys Asp 
545                 550                 555                 560 


Leu Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp 
                565                 570                 575     


Thr Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu 
            580                 585                 590         


Asp Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro 
        595                 600                 605             


Ser Val Glu Glu Thr Phe Arg Ala Asp Arg Leu 
    610                 615                 


<210>  666
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Ser Ile Pro Leu Lys Ser Ser Phe Leu Leu Ser Tyr Leu Cys Thr 
1               5                   10                  15      


Leu Pro Pro Ala Leu Leu Ser Arg Glu Ile Leu Met Ala Asp Ser Glu 
            20                  25                  30          


Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala Val Glu Ala Leu Leu 
        35                  40                  45              


Arg Ala Val Phe Gly Val Val Val Asp Glu Ala Ile Gln Lys Gly Thr 
    50                  55                  60                  


Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu Pro Glu Glu Leu Lys 
65                  70                  75                  80  


Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly Glu Ser Gln Lys Gln 
                85                  90                  95      


Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr Ser Val Lys Thr Gly 
            100                 105                 110         


His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly Leu Asp Pro His Ala 
        115                 120                 125             


Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn Thr Ser Gln Tyr Thr 
    130                 135                 140                 


Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu Glu Glu Val Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly Asp Gly Ile Phe Cys 
                165                 170                 175     


Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val Asn Leu Ala Arg Tyr 
            180                 185                 190         


Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu Arg Thr Leu Pro Pro 
        195                 200                 205             


Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr Ser Ile Gln Lys Gly 
    210                 215                 220                 


Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val Arg Val Val Lys Ala 
225                 230                 235                 240 


Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu Glu Arg Gln Ile Gly 
                245                 250                 255     


Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu Val Ser Ala Thr Ser 
            260                 265                 270         


Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Glu Ala Ile Ala Asp 
        275                 280                 285             


Val Cys Gln Arg His Gly Leu Trp Leu His Val Asp Ala Ala Trp Gly 
    290                 295                 300                 


Gly Ser Val Leu Leu Ser Gln Thr His Arg His Leu Leu Asp Gly Ile 
305                 310                 315                 320 


Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His Lys Leu Leu Ala Ala 
                325                 330                 335     


Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp Thr Ser Asn Leu Leu 
            340                 345                 350         


Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu Phe Gln Gln Asp Lys 
        355                 360                 365             


Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys Val Val Gln Cys Gly 
    370                 375                 380                 


Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met Trp Lys Ala Gln Gly 
385                 390                 395                 400 


Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala Phe Val Leu Ala Arg 
                405                 410                 415     


Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly Phe Glu Leu Val Met 
            420                 425                 430         


Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe Val Pro Pro Ser Leu 
        435                 440                 445             


Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu Arg Leu Ser Lys Val 
    450                 455                 460                 


Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu Gly Ser Met Met Ile 
465                 470                 475                 480 


Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe Phe Arg Val Val Val 
                485                 490                 495     


Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp Phe Leu Leu Asn Glu 
            500                 505                 510         


Leu Glu Arg Leu Gly Gln Asp Leu 
        515                 520 


<210>  667
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  667

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210>  668
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Thr Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Thr Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ala Thr Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala 
    290                 295                 300                 


Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn 
305                 310                 315                 320 


Pro Ala Thr Arg Gly Leu Pro Ser Thr Ala Ser Gly Arg Leu Arg Gly 
                325                 330                 335     


Thr Gln Glu Val Ala Pro Pro Thr Pro Leu Thr Pro Thr Ser His Thr 
            340                 345                 350         


Ala Asn Thr Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys 
        355                 360                 365             


Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser 
    370                 375                 380                 


Asp Leu Thr Gly Arg Gln Asp Thr Ser Arg Met Ser Thr Ser Gln Ile 
385                 390                 395                 400 


Pro Gly Arg Val Ala Ser Ser Gly Leu Gln Ser Val Val His Arg 
                405                 410                 415 


<210>  669
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  669

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  670
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Ala Leu Val Asp Lys His Lys Val Lys Arg Gln Arg Leu Asp Arg 
1               5                   10                  15      


Ile Cys Glu Gly Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro 
            20                  25                  30          


Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met 
        35                  40                  45              


Pro Ile Leu Lys Asp Leu Ala Thr Val Ala Phe Cys Asp Ala Gln Ser 
    50                  55                  60                  


Thr Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met 
65                  70                  75                  80  


Met Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys 
                85                  90                  95      


Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp 
            100                 105                 110         


Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser 
        115                 120                 125             


Ala Ala Val Glu Glu Thr Ala Asp Ser Thr Ile Cys His Ile Leu Asn 
    130                 135                 140                 


Leu Tyr Arg Arg Asn Thr Trp Leu Tyr Gln Ala Leu Arg Glu Gly Thr 
145                 150                 155                 160 


Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala 
                165                 170                 175     


Arg Ile Arg Gly Glu Thr Leu Gly Leu Ile Gly Phe Gly Arg Thr Gly 
            180                 185                 190         


Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe 
        195                 200                 205             


Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln 
    210                 215                 220                 


Arg Val Tyr Thr Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser 
225                 230                 235                 240 


Leu His Cys Asn Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe 
                245                 250                 255     


Thr Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg 
            260                 265                 270         


Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly 
        275                 280                 285             


Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser 
    290                 295                 300                 


Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro 
305                 310                 315                 320 


His Thr Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala 
                325                 330                 335     


Ala Ala Thr Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Glu Ser 
            340                 345                 350         


Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Thr Ser Ala Pro Trp 
        355                 360                 365             


Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Thr 
    370                 375                 380                 


Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro 
385                 390                 395                 400 


Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro Val Thr His Asn 
                405                 410                 415     


Leu Pro Thr Val Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro 
            420                 425                 430         


Thr Lys His Gly Asp Asn Arg Glu His Pro Asn Glu Gln 
        435                 440                 445 


<210>  671
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  671

Met Glu His Gly Ser Ile Ile Thr Gln Ala Arg Arg Glu Asp Ala Leu 
1               5                   10                  15      


Val Leu Thr Lys Gln Gly Leu Val Ser Lys Ser Ser Pro Lys Lys Pro 
            20                  25                  30          


Arg Gly Arg Asn Ile Phe Lys Ala Leu Phe Cys Cys Phe Arg Ala Gln 
        35                  40                  45              


His Val Gly Gln Ser Ser Ser Ser Thr Glu Leu Ala Ala Tyr Lys Glu 
    50                  55                  60                  


Glu Ala Asn Thr Ile Ala Lys Ser Asp Leu Leu Gln Cys Leu Gln Tyr 
65                  70                  75                  80  


Gln Phe Tyr Gln Ile Pro Gly Thr Cys Leu Leu Pro Glu Val Thr Glu 
                85                  90                  95      


Glu Asp Gln Gly Arg Ile Cys Val Val Ile Asp Leu Asp Glu Thr Leu 
            100                 105                 110         


Val His Ser Ser Phe Lys Pro Ile Asn Asn Ala Asp Phe Ile Val Pro 
        115                 120                 125             


Ile Glu Ile Glu Gly Thr Thr His Gln Val Tyr Val Leu Lys Arg Pro 
    130                 135                 140                 


Tyr Val Asp Glu Phe Leu Arg Arg Met Gly Glu Leu Phe Glu Cys Val 
145                 150                 155                 160 


Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp Pro Val Thr Asp Leu 
                165                 170                 175     


Leu Asp Arg Cys Gly Val Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys 
            180                 185                 190         


Val Phe His Gln Gly Cys Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg 
        195                 200                 205             


Asp Leu Arg Lys Thr Leu Ile Leu Asp Asn Ser Pro Ala Ser Tyr Ile 
    210                 215                 220                 


Phe His Pro Glu Asn Ala Val Pro Val Gln Ser Trp Phe Asp Asp Met 
225                 230                 235                 240 


Ala Asp Thr Glu Leu Leu Asn Leu Ile Pro Ile Phe Glu Glu Leu Ser 
                245                 250                 255     


Gly Ala Glu Asp Val Tyr Thr Ser Leu Gly Gln Leu Arg Ala Pro 
            260                 265                 270     


<210>  672
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Ser Ser Thr Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15      


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30          


Thr Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Thr His 
        35                  40                  45              


Val Tyr Asn Tyr Cys Thr Ser Val His Gln Ser Asn Gln Ala Arg Gly 
    50                  55                  60                  


Ala Gly Val Pro Pro Ser Lys Ser Lys Lys Gly Gln Thr Pro Gly Gly 
65                  70                  75                  80  


Ala Gln Phe Val Gly Leu Glu Leu Tyr Lys Arg Leu Lys Glu Phe Leu 
                85                  90                  95      


Lys Asn Tyr Leu Thr Asn Leu Leu Lys Asp Gly Glu Asp Leu Met Asp 
            100                 105                 110         


Glu Ser Val Leu Lys Phe Tyr Thr Gln Gln Trp Glu Asp Tyr Arg Phe 
        115                 120                 125             


Ser Ser Lys Val Leu Asn Gly Ile Cys Ala Tyr Leu Asn Arg His Trp 
    130                 135                 140                 


Val Arg Arg Glu Cys Asp Glu Gly Arg Lys Gly Ile Tyr Glu Ile Tyr 
145                 150                 155                 160 


Ser Leu Ala Leu Val Thr Trp Arg Asp Cys Leu Phe Arg Pro Leu Asn 
                165                 170                 175     


Lys Gln Val Thr Asn Ala Val Leu Lys Leu Ile Glu Lys Glu Arg Asn 
            180                 185                 190         


Gly Glu Thr Ile Asn Thr Arg Leu Ile Ser Gly Val Val Gln Ser Tyr 
        195                 200                 205             


Val Glu Leu Gly Leu Asn Glu Asp Asp Ala Phe Ala Lys Gly Pro Thr 
    210                 215                 220                 


Leu Thr Val Tyr Lys Glu Ser Phe Glu Ser Gln Phe Leu Ala Asp Thr 
225                 230                 235                 240 


Glu Arg Phe Tyr Thr Arg Glu Ser Thr Glu Phe Leu Gln Gln Asn Pro 
                245                 250                 255     


Val Thr Glu Tyr Met Lys Lys Ala Glu Ala Arg Leu Leu Glu Glu Gln 
            260                 265                 270         


Arg Arg Val Gln Val Tyr Leu His Glu Ser Thr Gln Asp Glu Leu Ala 
        275                 280                 285             


Arg Lys Cys Glu Gln Val Leu Ile Glu Lys His Leu Glu Ile Phe His 
    290                 295                 300                 


Thr Glu Phe Gln Asn Leu Leu Asp Ala Asp Lys Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Arg Met Tyr Asn Leu Val Ser Arg Ile Gln Asp Gly Leu Gly Glu Leu 
                325                 330                 335     


Lys Lys Leu Leu Glu Thr His Ile His Asn Gln Gly Leu Ala Ala Ile 
            340                 345                 350         


Glu Lys Cys Gly Glu Ala Ala Leu Asn Asp Pro Lys Met Tyr Val Gln 
        355                 360                 365             


Thr Val Leu Asp Val His Lys Lys Tyr Asn Ala Leu Val Met Ser Ala 
    370                 375                 380                 


Phe Asn Asn Asp Ala Gly Phe Val Ala Ala Leu Asp Lys Ala Cys Gly 
385                 390                 395                 400 


Arg Phe Ile Asn Asn Asn Ala Val Thr Lys Met Ala Gln Ser Ser Ser 
                405                 410                 415     


Lys Ser Pro Glu Leu Leu Ala Arg Tyr Cys Asp Ser Leu Leu Lys Lys 
            420                 425                 430         


Ser Ser Lys Asn Pro Glu Glu Ala Glu Leu Glu Asp Thr Leu Asn Gln 
        435                 440                 445             


Val Met Val Val Phe Lys Tyr Ile Glu Asp Lys Asp Val Phe Gln Lys 
    450                 455                 460                 


Phe Tyr Ala Lys Met Leu Ala Lys Arg Leu Val His Gln Asn Ser Ala 
465                 470                 475                 480 


Ser Asp Asp Ala Glu Ala Ser Met Ile Ser Lys Leu Lys Gln Ala Cys 
                485                 490                 495     


Gly Phe Glu Tyr Thr Ser Lys Leu Gln Arg Met Phe Gln Asp Ile Gly 
            500                 505                 510         


Val Ser Lys Asp Leu Asn Glu Gln Phe Lys Lys His Leu Thr Asn Ser 
        515                 520                 525             


Glu Pro Leu Asp Leu Asp Phe Ser Ile Gln Val Leu Ser Ser Gly Ser 
    530                 535                 540                 


Trp Pro Phe Gln Gln Ser Cys Thr Phe Ala Leu Pro Ser Glu Leu Glu 
545                 550                 555                 560 


Arg Ser Tyr Gln Arg Phe Thr Ala Phe Tyr Ala Ser Arg His Ser Gly 
                565                 570                 575     


Arg Lys Leu Thr Trp Leu Tyr Gln Leu Ser Lys Gly Glu Leu Val Thr 
            580                 585                 590         


Asn Cys Phe Lys Asn Arg Tyr Thr Leu Gln Ala Ser Thr Phe Gln Met 
        595                 600                 605             


Ala Ile Leu Leu Gln Tyr Asn Thr Glu Asp Ala Tyr Thr Val Gln Gln 
    610                 615                 620                 


Leu Thr Asp Ser Thr Gln Ile Lys Met Asp Ile Leu Ala Gln Val Leu 
625                 630                 635                 640 


Gln Ile Leu Leu Lys Ser Lys Leu Leu Val Leu Glu Asp Glu Asn Ala 
                645                 650                 655     


Asn Val Asp Glu Val Glu Leu Lys Pro Asp Thr Leu Ile Lys Leu Tyr 
            660                 665                 670         


Leu Gly Tyr Lys Asn Lys Lys Leu Arg Val Asn Ile Asn Val Pro Met 
        675                 680                 685             


Lys Thr Glu Gln Lys Gln Glu Gln Glu Thr Thr His Lys Asn Ile Glu 
    690                 695                 700                 


Glu Asp Arg Lys Leu Leu Ile Gln Ala Ala Ile Val Arg Ile Met Lys 
705                 710                 715                 720 


Met Arg Lys Val Leu Lys His Gln Gln Leu Leu Gly Glu Val Leu Thr 
                725                 730                 735     


Gln Leu Ser Ser Arg Phe Lys Pro Arg Val Pro Val Ile Lys Lys Cys 
            740                 745                 750         


Ile Asp Ile Leu Ile Glu Lys Glu Tyr Leu Glu Arg Val Asp Gly Glu 
        755                 760                 765             


Lys Asp Thr Tyr Ser Tyr Leu Ala 
    770                 775     


<210>  673
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  673

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Thr Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955     


<210>  674
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Asp Leu Cys His Pro Glu Pro Ala Glu Leu Ser Ser Gly Glu Thr 
1               5                   10                  15      


Glu Glu Leu Gln Arg Ile Lys Trp His Arg Lys Gln Leu Leu Glu Asp 
            20                  25                  30          


Ile Gln Lys Leu Lys Asp Glu Ile Ala Asp Val Phe Ala Gln Ile Asp 
        35                  40                  45              


Cys Phe Glu Ser Ala Glu Glu Ser Arg Met Ala Gln Lys Glu Lys Glu 
    50                  55                  60                  


Leu Cys Ile Gly Arg Lys Lys Phe Asn Met Asp Pro Ala Lys Gly Ile 
65                  70                  75                  80  


Gln Tyr Phe Ile Glu His Lys Leu Leu Thr Pro Asp Val Gln Asp Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile Gly 
            100                 105                 110         


Thr Tyr Leu Gly Glu Arg Asp Pro Ile Asn Leu Gln Val Leu Gln Ala 
        115                 120                 125             


Phe Val Asp Cys His Glu Phe Ala Asn Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
145                 150                 155                 160 


Asp Arg Met Met Glu Ala Phe Ala Thr Arg Tyr Cys Leu Cys Asn Pro 
                165                 170                 175     


Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ser Ile 
            180                 185                 190         


Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Arg Asp Arg Pro 
        195                 200                 205             


Pro Phe Glu Arg Phe Val Ser Met Asn Arg Gly Ile Asn Asn Gly Ser 
    210                 215                 220                 


Asp Leu Pro Glu Asp Gln Leu Arg Asn Leu Phe Asp Ser Ile Lys Ser 
225                 230                 235                 240 


Glu Pro Phe Ser Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His Thr 
                245                 250                 255     


Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Arg 
            260                 265                 270         


Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys Leu 
        275                 280                 285             


Tyr Tyr Phe Glu Phe Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile Pro 
    290                 295                 300                 


Leu Glu Asn Leu Ser Val Gln Lys Val Asp Asp Pro Lys Lys Pro Phe 
305                 310                 315                 320 


Cys Leu Glu Leu Tyr Asn Pro Ser Cys Arg Gly Gln Lys Ile Lys Ala 
                325                 330                 335     


Cys Lys Thr Asp Gly Asp Gly Arg Val Val Glu Gly Lys His Glu Ser 
            340                 345                 350         


Tyr Arg Ile Ser Ala Thr Ser Ala Glu Glu Arg Asp Gln Trp Ile Glu 
        355                 360                 365             


Ser Ile Arg Ala Ser Ile Thr Arg Val Pro Phe Tyr Asp Leu Val Ser 
    370                 375                 380                 


Thr Arg Lys Lys Lys Ile Ala Ser Lys Gln 
385                 390                 


<210>  675
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  675

Met Glu Thr Lys Arg Val Glu Ile Pro Gly Ser Val Leu Asp Asp Leu 
1               5                   10                  15      


Cys Ser Arg Phe Ile Leu His Ile Pro Ser Glu Glu Arg Asp Asn Ala 
            20                  25                  30          


Ile Arg Val Cys Phe Gln Ile Glu Leu Ala His Trp Phe Tyr Leu Asp 
        35                  40                  45              


Phe Tyr Met Gln Asn Thr Pro Gly Leu Pro Gln Cys Gly Ile Arg Asp 
    50                  55                  60                  


Phe Ala Lys Ala Val Phe Ser His Cys Pro Phe Leu Leu Pro Gln Gly 
65                  70                  75                  80  


Glu Asp Val Glu Lys Val Leu Asp Glu Trp Lys Glu Tyr Lys Met Gly 
                85                  90                  95      


Val Pro Thr Tyr Gly Ala Ile Ile Leu Asp Glu Thr Leu Glu Asn Val 
            100                 105                 110         


Leu Leu Val Gln Gly Tyr Leu Ala Lys Ser Gly Trp Gly Phe Pro Lys 
        115                 120                 125             


Gly Lys Val Asn Lys Glu Glu Ala Pro His Asp Cys Ala Ala Arg Glu 
    130                 135                 140                 


Val Phe Glu Glu Thr Gly Phe Asp Ile Lys Asp Tyr Ile Cys Lys Asp 
145                 150                 155                 160 


Asp Tyr Ile Glu Leu Arg Ile Asn Asp Gln Leu Ala Arg Leu Tyr Ile 
                165                 170                 175     


Ile Pro Gly Ile Pro Lys Asp Thr Lys Phe Asn Pro Lys Thr Arg Arg 
            180                 185                 190         


Glu Ile Arg Asn Ile Glu Trp Phe Ser Ile Glu Lys Leu Pro Cys His 
        195                 200                 205             


Arg Asn Asp Met Thr Pro Lys Ser Lys Leu Gly Leu Ala Pro Asn Lys 
    210                 215                 220                 


Phe Phe Met Ala Ile Pro Phe Ile Arg Pro Leu Arg Asp Trp Leu Ser 
225                 230                 235                 240 


Arg Arg Phe Gly Asp Ser Ser Asp Ser Asp Asn Gly Phe Ser Ser Thr 
                245                 250                 255     


Gly Ser Thr Pro Ala Lys Pro Thr Val Glu Lys Leu Ser Arg Thr Lys 
            260                 265                 270         


Phe Arg His Ser Gln Gln Leu Phe Pro Asp Gly Ser Pro Gly Asp Gln 
        275                 280                 285             


Trp Val Lys His Arg Gln Pro Leu Gln Gln Lys Pro Tyr Asn Asn His 
    290                 295                 300                 


Ser Glu Met Ser Asp Leu Leu Lys Gly Lys Asn Gln Ser Met Arg Gly 
305                 310                 315                 320 


Asn Gly Arg Lys Gln Tyr Gln Asp Ser Pro Asn Gln Lys Lys Arg Thr 
                325                 330                 335     


Asn Gly Leu Gln Pro Ala Lys Gln Gln Asn Ser Leu Met Lys Cys Glu 
            340                 345                 350         


Lys Lys Leu His Pro Arg Lys Leu Gln Asp Asn Phe Glu Thr Asp Ala 
        355                 360                 365             


Val Tyr Asp Leu Pro Ser Ser Ser Glu Asp Gln Leu Leu Glu His Ala 
    370                 375                 380                 


Glu Gly Gln Pro Val Ala Cys Asn Gly His Cys Lys Phe Pro Phe Ser 
385                 390                 395                 400 


Ser Arg Ala Phe Leu Ser Phe Lys Phe Asp His Asn Ala Ile Met Lys 
                405                 410                 415     


Ile Leu Asp Leu 
            420 


<210>  676
<211>  1712
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Glu Arg Asn Val Leu Thr Thr Phe Ser Gln Glu Met Ser Gln Leu 
1               5                   10                  15      


Ile Leu Asn Glu Met Pro Lys Ala Glu Tyr Ser Ser Leu Phe Asn Asp 
            20                  25                  30          


Phe Val Glu Ser Glu Phe Phe Leu Ile Asp Gly Asp Ser Leu Leu Ile 
        35                  40                  45              


Thr Cys Ile Cys Glu Ile Ser Phe Lys Pro Gly Gln Asn Leu His Phe 
    50                  55                  60                  


Phe Tyr Leu Val Glu Arg Tyr Leu Val Asp Leu Ile Ser Lys Gly Gly 
65                  70                  75                  80  


Gln Phe Thr Ile Val Phe Phe Lys Asp Ala Glu Tyr Ala Tyr Phe Asn 
                85                  90                  95      


Phe Pro Glu Leu Leu Ser Leu Arg Thr Ala Leu Ile Leu His Leu Gln 
            100                 105                 110         


Lys Asn Thr Thr Ile Asp Val Arg Thr Thr Phe Ser Arg Cys Leu Ser 
        115                 120                 125             


Lys Glu Trp Gly Ser Phe Leu Glu Glu Ser Tyr Pro Tyr Phe Leu Ile 
    130                 135                 140                 


Val Ala Asp Glu Gly Leu Asn Asp Leu Gln Thr Gln Leu Phe Asn Phe 
145                 150                 155                 160 


Leu Ile Ile His Ser Trp Ala Arg Lys Val Asn Val Val Leu Ser Ser 
                165                 170                 175     


Gly Gln Glu Ser Asp Val Leu Cys Leu Tyr Ala Tyr Leu Leu Pro Ser 
            180                 185                 190         


Met Tyr Arg His Gln Ile Phe Ser Trp Lys Asn Lys Gln Asn Ile Lys 
        195                 200                 205             


Asp Ala Tyr Thr Thr Leu Leu Asn Gln Leu Glu Arg Phe Lys Leu Ser 
    210                 215                 220                 


Ala Leu Ala Pro Leu Phe Gly Ser Leu Lys Trp Asn Asn Ile Thr Glu 
225                 230                 235                 240 


Glu Ala His Lys Thr Val Ser Leu Leu Thr Gln Val Trp Pro Glu Gly 
                245                 250                 255     


Ser Asp Ile Arg Arg Val Phe Cys Val Thr Ser Cys Ser Leu Ser Leu 
            260                 265                 270         


Arg Met Tyr His Arg Phe Leu Gly Asn Arg Glu Pro Ser Ser Gly Gln 
        275                 280                 285             


Glu Thr Glu Ile Gln Gln Val Asn Ser Asn Cys Leu Thr Leu Gln Glu 
    290                 295                 300                 


Met Glu Asp Leu Cys Lys Leu His Cys Leu Thr Val Val Phe Leu Leu 
305                 310                 315                 320 


His Leu Pro Leu Ser Gln Arg Ala Cys Ala Arg Val Ile Thr Ser His 
                325                 330                 335     


Trp Ala Glu Asp Met Lys Pro Leu Leu Gln Met Lys Lys Trp Cys Glu 
            340                 345                 350         


Tyr Phe Ile Leu Arg Asn Ile His Thr Phe Glu Phe Trp Asn Leu Asn 
        355                 360                 365             


Leu Ile His Leu Ser Asp Leu Asn Asp Glu Leu Leu Leu Lys Asn Ile 
    370                 375                 380                 


Ala Phe Tyr Tyr Glu Asn Glu Asn Val Lys Gly Leu His Leu Asn Leu 
385                 390                 395                 400 


Gly Asp Thr Ile Met Lys Asp Tyr Glu Tyr Leu Trp Asn Thr Val Ser 
                405                 410                 415     


Lys Leu Val Arg Asp Phe Glu Val Gly Gln Pro Phe Pro Leu Arg Thr 
            420                 425                 430         


Thr Lys Val Cys Phe Leu Glu Lys Lys Pro Ser Pro Ile Lys Asp Ser 
        435                 440                 445             


Ser Asn Glu Met Val Pro Asn Leu Gly Phe Ile Pro Thr Ser Ser Phe 
    450                 455                 460                 


Val Val Asp Lys Phe Ala Gly Asp Ile Leu Lys Asp Leu Pro Phe Leu 
465                 470                 475                 480 


Lys Ser Asp Asp Pro Ile Val Thr Ser Leu Val Lys Gln Lys Glu Phe 
                485                 490                 495     


Asp Glu Leu Val His Trp His Ser His Lys Pro Leu Ser Asp Asp Tyr 
            500                 505                 510         


Asp Arg Ser Arg Cys Gln Phe Asp Glu Lys Ser Arg Asp Pro Arg Val 
        515                 520                 525             


Leu Arg Ser Val Gln Lys Tyr His Val Phe Gln Arg Phe Tyr Gly Asn 
    530                 535                 540                 


Ser Leu Glu Thr Val Ser Ser Lys Ile Ile Val Thr Gln Thr Ile Lys 
545                 550                 555                 560 


Ser Lys Lys Asp Phe Ser Gly Pro Lys Ser Lys Lys Ala His Glu Thr 
                565                 570                 575     


Lys Ala Glu Ile Ile Ala Arg Glu Asn Lys Lys Arg Leu Phe Ala Arg 
            580                 585                 590         


Glu Glu Gln Lys Glu Glu Gln Lys Trp Asn Ala Leu Ser Phe Ser Ile 
        595                 600                 605             


Glu Glu Gln Leu Lys Glu Asn Leu His Ser Gly Ile Lys Ser Leu Glu 
    610                 615                 620                 


Asp Phe Leu Lys Ser Cys Lys Ser Ser Cys Val Lys Leu Gln Val Glu 
625                 630                 635                 640 


Met Val Gly Leu Thr Ala Cys Leu Lys Ala Trp Lys Glu His Cys Arg 
                645                 650                 655     


Ser Glu Glu Gly Lys Thr Thr Lys Asp Leu Ser Ile Ala Val Gln Val 
            660                 665                 670         


Met Lys Arg Ile His Ser Leu Met Glu Lys Tyr Ser Glu Leu Leu Gln 
        675                 680                 685             


Glu Asp Asp Arg Gln Leu Ile Ala Arg Cys Leu Lys Tyr Leu Gly Phe 
    690                 695                 700                 


Asp Glu Leu Ala Ser Ser Leu His Pro Ala Gln Asp Ala Glu Asn Asp 
705                 710                 715                 720 


Val Lys Val Lys Lys Arg Asn Lys Tyr Ser Val Gly Ile Gly Pro Ala 
                725                 730                 735     


Arg Phe Gln Leu Gln Tyr Met Gly His Tyr Leu Ile Arg Asp Glu Arg 
            740                 745                 750         


Lys Asp Pro Asp Pro Arg Val Gln Asp Phe Ile Pro Asp Thr Trp Gln 
        755                 760                 765             


Arg Glu Leu Leu Asp Val Val Asp Lys Asn Glu Ser Ala Val Ile Val 
    770                 775                 780                 


Ala Pro Thr Ser Ser Gly Lys Thr Tyr Ala Ser Tyr Tyr Cys Met Glu 
785                 790                 795                 800 


Lys Val Leu Lys Glu Ser Asp Asp Gly Val Val Val Tyr Val Ala Pro 
                805                 810                 815     


Thr Lys Ala Leu Val Asn Gln Val Ala Ala Thr Val Gln Asn Arg Phe 
            820                 825                 830         


Thr Lys Asn Leu Pro Ser Gly Glu Val Leu Cys Gly Val Phe Thr Arg 
        835                 840                 845             


Glu Tyr Arg His Asp Ala Leu Asn Cys Gln Val Leu Ile Thr Val Pro 
    850                 855                 860                 


Ala Cys Phe Glu Ile Leu Leu Leu Ala Pro His Arg Gln Asn Trp Val 
865                 870                 875                 880 


Lys Lys Ile Arg Tyr Val Ile Phe Asp Glu Val His Cys Leu Gly Gly 
                885                 890                 895     


Glu Ile Gly Ala Glu Ile Trp Glu His Leu Leu Val Met Ile Arg Cys 
            900                 905                 910         


Pro Phe Leu Ala Leu Ser Ala Thr Ile Ser Asn Pro Glu His Leu Thr 
        915                 920                 925             


Glu Trp Leu Gln Ser Val Lys Trp Tyr Trp Lys Gln Glu Asp Lys Ile 
    930                 935                 940                 


Ile Glu Asn Asn Thr Ala Ser Lys Arg His Val Gly Arg Gln Ala Gly 
945                 950                 955                 960 


Phe Pro Lys Asp Tyr Leu Gln Val Lys Gln Ser Tyr Lys Val Arg Leu 
                965                 970                 975     


Val Leu Tyr Gly Glu Arg Tyr Asn Asp Leu Glu Lys His Val Cys Ser 
            980                 985                 990         


Ile Lys His Gly Asp Ile His Phe  Asp His Phe His Pro  Cys Ala Ala 
        995                 1000                 1005             


Leu Thr  Thr Asp His Ile Glu  Arg Tyr Gly Phe Pro  Pro Asp Leu 
    1010                 1015                 1020             


Thr Leu  Ser Pro Arg Glu Ser  Ile Gln Leu Tyr Asp  Ala Met Phe 
    1025                 1030                 1035             


Gln Ile  Trp Lys Ser Trp Pro  Arg Ala Gln Glu Leu  Cys Pro Glu 
    1040                 1045                 1050             


Asn Phe  Ile His Phe Asn Asn  Lys Leu Val Ile Lys  Lys Met Asp 
    1055                 1060                 1065             


Ala Arg  Lys Tyr Glu Glu Ser  Leu Lys Ala Glu Leu  Thr Ser Trp 
    1070                 1075                 1080             


Ile Lys  Asn Gly Asn Val Glu  Gln Ala Arg Met Val  Leu Gln Asn 
    1085                 1090                 1095             


Leu Ser  Pro Glu Ala Asp Leu  Ser Pro Glu Asn Met  Ile Thr Met 
    1100                 1105                 1110             


Phe Pro  Leu Leu Val Glu Lys  Leu Arg Lys Met Glu  Lys Leu Pro 
    1115                 1120                 1125             


Ala Leu  Phe Phe Leu Phe Lys  Leu Gly Ala Val Glu  Asn Ala Ala 
    1130                 1135                 1140             


Glu Ser  Val Ser Thr Phe Leu  Lys Lys Lys Gln Glu  Thr Lys Arg 
    1145                 1150                 1155             


Pro Pro  Lys Ala Asp Lys Glu  Ala His Val Met Ala  Asn Lys Leu 
    1160                 1165                 1170             


Arg Lys  Val Lys Lys Ser Ile  Glu Lys Gln Lys Ile  Ile Asp Glu 
    1175                 1180                 1185             


Lys Ser  Gln Lys Lys Thr Arg  Asn Val Asp Gln Ser  Leu Ile His 
    1190                 1195                 1200             


Glu Ala  Glu His Asp Asn Leu  Val Lys Cys Leu Glu  Lys Asn Leu 
    1205                 1210                 1215             


Glu Ile  Pro Gln Asp Cys Thr  Tyr Ala Asp Gln Lys  Ala Val Asp 
    1220                 1225                 1230             


Thr Glu  Thr Leu Gln Lys Val  Phe Gly Arg Val Lys  Phe Glu Arg 
    1235                 1240                 1245             


Lys Gly  Glu Glu Leu Lys Ala  Leu Ala Glu Arg Gly  Ile Gly Tyr 
    1250                 1255                 1260             


His His  Ser Ala Met Ser Phe  Lys Glu Lys Gln Leu  Val Glu Ile 
    1265                 1270                 1275             


Leu Phe  Arg Lys Gly Tyr Leu  Arg Val Val Thr Ala  Thr Gly Thr 
    1280                 1285                 1290             


Leu Ala  Leu Gly Val Asn Met  Pro Cys Lys Ser Val  Val Phe Ala 
    1295                 1300                 1305             


Gln Asn  Ser Val Tyr Leu Asp  Ala Leu Asn Tyr Arg  Gln Met Ser 
    1310                 1315                 1320             


Gly Arg  Ala Gly Arg Arg Gly  Gln Asp Leu Met Gly  Asp Val Tyr 
    1325                 1330                 1335             


Phe Phe  Asp Ile Pro Phe Pro  Lys Ile Gly Lys Leu  Ile Lys Ser 
    1340                 1345                 1350             


Asn Val  Pro Glu Leu Arg Gly  His Phe Pro Leu Ser  Ile Thr Leu 
    1355                 1360                 1365             


Val Leu  Arg Leu Met Leu Leu  Ala Ser Lys Gly Asp  Asp Pro Glu 
    1370                 1375                 1380             


Asp Ala  Lys Ala Lys Val Leu  Ser Val Leu Lys His  Ser Leu Leu 
    1385                 1390                 1395             


Ser Phe  Lys Gln Pro Arg Val  Met Asp Met Leu Lys  Leu Tyr Phe 
    1400                 1405                 1410             


Leu Phe  Ser Leu Gln Phe Leu  Val Lys Glu Gly Tyr  Leu Asp Gln 
    1415                 1420                 1425             


Glu Gly  Asn Pro Met Gly Phe  Ala Gly Leu Val Ser  His Leu His 
    1430                 1435                 1440             


Tyr His  Glu Pro Ser Asn Leu  Val Phe Val Ser Phe  Leu Val Asn 
    1445                 1450                 1455             


Gly Leu  Phe His Asp Leu Cys  Gln Pro Thr Arg Lys  Gly Ser Lys 
    1460                 1465                 1470             


His Phe  Ser Gln Asp Val Met  Glu Lys Leu Val Leu  Val Leu Ala 
    1475                 1480                 1485             


His Leu  Phe Gly Arg Arg Tyr  Phe Pro Pro Lys Phe  Gln Asp Ala 
    1490                 1495                 1500             


His Phe  Glu Phe Tyr Gln Ser  Lys Val Phe Leu Asp  Asp Leu Pro 
    1505                 1510                 1515             


Glu Asp  Phe Ser Asp Ala Leu  Asp Glu Tyr Asn Met  Lys Ile Met 
    1520                 1525                 1530             


Glu Asp  Phe Thr Thr Phe Leu  Arg Ile Val Ser Lys  Leu Ala Asp 
    1535                 1540                 1545             


Met Asn  Gln Glu Tyr Gln Leu  Pro Leu Ser Lys Ile  Lys Phe Thr 
    1550                 1555                 1560             


Gly Lys  Glu Cys Glu Asp Ser  Gln Leu Val Ser His  Leu Met Ser 
    1565                 1570                 1575             


Cys Lys  Glu Gly Arg Val Ala  Ile Ser Pro Phe Val  Cys Leu Ser 
    1580                 1585                 1590             


Gly Asn  Phe Asp Asp Asp Leu  Leu Arg Leu Glu Thr  Pro Asn His 
    1595                 1600                 1605             


Val Thr  Leu Gly Thr Ile Gly  Val Asn Arg Ser Gln  Ala Pro Val 
    1610                 1615                 1620             


Leu Leu  Ser Gln Lys Phe Asp  Asn Arg Gly Arg Lys  Met Ser Leu 
    1625                 1630                 1635             


Asn Ala  Tyr Ala Leu Asp Phe  Tyr Lys His Gly Ser  Leu Ile Gly 
    1640                 1645                 1650             


Leu Val  Gln Asp Asn Arg Met  Asn Glu Gly Asp Ala  Tyr Tyr Leu 
    1655                 1660                 1665             


Leu Lys  Asp Phe Ala Leu Thr  Ile Lys Ser Ile Ser  Val Ser Leu 
    1670                 1675                 1680             


Arg Glu  Leu Cys Glu Asn Glu  Asp Asp Asn Val Val  Leu Ala Phe 
    1685                 1690                 1695             


Glu Gln  Leu Ser Thr Thr Phe  Trp Glu Lys Leu Asn  Lys Val 
    1700                 1705                 1710         


<210>  677
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  677

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Phe Leu 
            100                 105                 110         


Gly Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  678
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala Gln Leu 
1               5                   10                  15      


Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val Leu Lys 
            20                  25                  30          


Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp Ala Ile 
        35                  40                  45              


Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp 
    50                  55                  60                  


Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr 
65                  70                  75                  80  


Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val Cys Leu 
                85                  90                  95      


Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu 
            100                 105                 110         


Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly 
        115                 120                 125             


Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met Met Arg 
    130                 135                 140                 


Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser 
                165                 170                 175     


Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu Leu Val 
            180                 185                 190         


Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His Met Trp 
        195                 200                 205             


Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser 
    210                 215                 220                 


Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr 
225                 230                 235                 240 


Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu Val Ser 
                245                 250                 255     


Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His Val Trp 
            260                 265                 270         


Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys 
        275                 280                 285             


Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp Cys His 
    290                 295                 300                 


Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu Cys Asp 
305                 310                 315                 320 


Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile Tyr Pro 
                325                 330                 335     


Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln 
            340                 345                 350         


Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile 
        355                 360                 365             


Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile 
                405                 410                 415     


Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu Val Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala 
        435                 440                 445             


Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln 
465                 470                 475                 480 


Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val Val His 
                485                 490                 495     


Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu Glu Lys 
            500                 505                 510         


Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly 
        515                 520                 525             


Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu 
545                 550                 555                 560 


Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu 
                565                 570                 575     


Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu 
            580                 585                 590         


Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His Gly Gly 
        595                 600                 605             


Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile Tyr Gly 
    610                 615                 620                 


Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp Pro Asp 
625                 630                 635                 640 


Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu Glu Val 
                645                 650                 655     


Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu 
            660                 665                 670         


Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr Phe His 
        675                 680                 685             


Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln 
    690                 695                 700                 


Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro Met Leu 
705                 710                 715                 720 


Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu Ser 
                725                 730                 735 


<210>  679
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  679

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


<210>  680
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Met Tyr His Leu Gly Val Gly Leu Leu Asp Pro Ser Arg Ser 
    530                 535                 540                 


Phe Trp Ile Ala Ile Pro Trp Ala Cys Pro Gly Leu Gly Val Ala Ala 
545                 550                 555                 560 


Leu Cys 
        


<210>  681
<211>  2068
<212>  PRT
<213>  Homo sapiens

<400>  681

Met Gln Ala Asp Lys Cys Arg Thr Ser Ser Arg Ser Val Lys Lys Glu 
1               5                   10                  15      


Leu Val Ile Glu Ser Pro Leu Gln Tyr Lys Asp Ala Ala Gln Gly Glu 
            20                  25                  30          


Val Glu Ala Glu Ser Pro Gly Pro Val Pro Ala Lys Pro Lys Leu Ile 
        35                  40                  45              


Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln Ile 
    50                  55                  60                  


Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp Phe 
65                  70                  75                  80  


Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr Val 
                85                  90                  95      


Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu Cys 
            100                 105                 110         


Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr Glu 
        115                 120                 125             


Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys Leu 
    130                 135                 140                 


Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp Lys 
145                 150                 155                 160 


Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr Lys 
                165                 170                 175     


His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val Thr 
            180                 185                 190         


Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly Asp 
        195                 200                 205             


Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys Glu 
    210                 215                 220                 


Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln Asn 
225                 230                 235                 240 


Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys Ser 
                245                 250                 255     


Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp Ile 
            260                 265                 270         


Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met Gln 
        275                 280                 285             


Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys Leu 
    290                 295                 300                 


Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala Lys 
305                 310                 315                 320 


Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val Lys 
                325                 330                 335     


Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser Ala 
            340                 345                 350         


Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile Leu 
        355                 360                 365             


Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala Glu 
    370                 375                 380                 


Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr Leu 
385                 390                 395                 400 


Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe His 
                405                 410                 415     


Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr Ser 
            420                 425                 430         


Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys Gly 
        435                 440                 445             


Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe Ser 
    450                 455                 460                 


Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu Lys 
465                 470                 475                 480 


Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys Ser 
                485                 490                 495     


Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys Gln 
            500                 505                 510         


Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala Ala 
        515                 520                 525             


Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg 
    530                 535                 540                 


Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp Asp 
545                 550                 555                 560 


Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala Lys 
                565                 570                 575     


Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val Ser 
            580                 585                 590         


Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys Gln 
        595                 600                 605             


Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu Phe 
    610                 615                 620                 


Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr Asn 
625                 630                 635                 640 


His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys Ser 
                645                 650                 655     


Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp Ser 
            660                 665                 670         


Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro Gly 
        675                 680                 685             


Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His His 
    690                 695                 700                 


Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr Gln 
705                 710                 715                 720 


Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser Cys 
                725                 730                 735     


Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu Thr 
            740                 745                 750         


Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val Val 
        755                 760                 765             


Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr 
    770                 775                 780                 


Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu Ile 
785                 790                 795                 800 


Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His Leu 
                805                 810                 815     


Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe Gln 
            820                 825                 830         


Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu Leu 
        835                 840                 845             


Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met Ile 
    850                 855                 860                 


Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr Arg 
865                 870                 875                 880 


Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile His 
                885                 890                 895     


Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg Ser 
            900                 905                 910         


Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr 
        915                 920                 925             


Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu Lys 
    930                 935                 940                 


Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp 
945                 950                 955                 960 


Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile Glu 
                965                 970                 975     


Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser Tyr 
            980                 985                 990         


His His Ala Val Glu Thr Val Val  Asn Met Leu Met Pro  His Ile Thr 
        995                 1000                 1005             


Gln Lys  Phe Arg Asp Asn Pro  Glu Ala Ser Lys Asn  Ala Asn His 
    1010                 1015                 1020             


Ser Leu  Ala Val Phe Ile Lys  Arg Cys Phe Thr Phe  Met Asp Arg 
    1025                 1030                 1035             


Gly Phe  Val Phe Lys Gln Ile  Asn Asn Tyr Ile Ser  Cys Phe Ala 
    1040                 1045                 1050             


Pro Gly  Asp Pro Lys Thr Leu  Phe Glu Tyr Lys Phe  Glu Phe Leu 
    1055                 1060                 1065             


Arg Val  Val Cys Asn His Glu  His Tyr Ile Pro Leu  Asn Leu Pro 
    1070                 1075                 1080             


Met Pro  Phe Gly Lys Gly Arg  Ile Gln Arg Tyr Gln  Asp Leu Gln 
    1085                 1090                 1095             


Leu Asp  Tyr Ser Leu Thr Asp  Glu Phe Cys Arg Asn  His Phe Leu 
    1100                 1105                 1110             


Val Gly  Leu Leu Leu Arg Glu  Val Gly Thr Ala Leu  Gln Glu Phe 
    1115                 1120                 1125             


Arg Glu  Val Arg Leu Ile Ala  Ile Ser Val Leu Lys  Asn Leu Leu 
    1130                 1135                 1140             


Ile Lys  His Ser Phe Asp Asp  Arg Tyr Ala Ser Arg  Ser His Gln 
    1145                 1150                 1155             


Ala Arg  Ile Ala Thr Leu Tyr  Leu Pro Leu Phe Gly  Leu Leu Ile 
    1160                 1165                 1170             


Glu Asn  Val Gln Arg Ile Asn  Val Arg Asp Val Ser  Pro Phe Pro 
    1175                 1180                 1185             


Val Asn  Ala Gly Met Thr Val  Lys Asp Glu Ser Leu  Ala Leu Pro 
    1190                 1195                 1200             


Ala Val  Asn Pro Leu Val Thr  Pro Gln Lys Gly Ser  Thr Leu Asp 
    1205                 1210                 1215             


Asn Ser  Leu His Lys Asp Leu  Leu Gly Ala Ile Ser  Gly Ile Ala 
    1220                 1225                 1230             


Ser Pro  Tyr Thr Thr Ser Thr  Pro Asn Ile Asn Ser  Val Arg Asn 
    1235                 1240                 1245             


Ala Asp  Ser Arg Gly Ser Leu  Ile Ser Thr Asp Ser  Gly Asn Ser 
    1250                 1255                 1260             


Leu Pro  Glu Arg Asn Ser Glu  Lys Ser Asn Ser Leu  Asp Lys His 
    1265                 1270                 1275             


Gln Gln  Ser Ser Thr Leu Gly  Asn Ser Val Val Arg  Cys Asp Lys 
    1280                 1285                 1290             


Leu Asp  Gln Ser Glu Ile Lys  Ser Leu Leu Met Cys  Phe Leu Tyr 
    1295                 1300                 1305             


Ile Leu  Lys Ser Met Ser Asp  Asp Ala Leu Phe Thr  Tyr Trp Asn 
    1310                 1315                 1320             


Lys Ala  Ser Thr Ser Glu Leu  Met Asp Phe Phe Thr  Ile Ser Glu 
    1325                 1330                 1335             


Val Cys  Leu His Gln Phe Gln  Tyr Met Gly Lys Arg  Tyr Ile Ala 
    1340                 1345                 1350             


Arg Thr  Gly Met Met His Ala  Arg Leu Gln Gln Leu  Gly Ser Leu 
    1355                 1360                 1365             


Asp Asn  Ser Leu Thr Phe Asn  His Ser Tyr Gly His  Ser Asp Ala 
    1370                 1375                 1380             


Asp Val  Leu His Gln Ser Leu  Leu Glu Ala Asn Ile  Ala Thr Glu 
    1385                 1390                 1395             


Val Cys  Leu Thr Ala Leu Asp  Thr Leu Ser Leu Phe  Thr Leu Ala 
    1400                 1405                 1410             


Phe Lys  Asn Gln Leu Leu Ala  Asp His Gly His Asn  Pro Leu Met 
    1415                 1420                 1425             


Lys Lys  Val Phe Asp Val Tyr  Leu Cys Phe Leu Gln  Lys His Gln 
    1430                 1435                 1440             


Ser Glu  Thr Ala Leu Lys Asn  Val Phe Thr Ala Leu  Arg Ser Leu 
    1445                 1450                 1455             


Ile Tyr  Lys Phe Pro Ser Thr  Phe Tyr Glu Gly Arg  Ala Asp Met 
    1460                 1465                 1470             


Cys Ala  Ala Leu Cys Tyr Glu  Ile Leu Lys Cys Cys  Asn Ser Lys 
    1475                 1480                 1485             


Leu Ser  Ser Ile Arg Thr Glu  Ala Ser Gln Leu Leu  Tyr Phe Leu 
    1490                 1495                 1500             


Met Arg  Asn Asn Phe Asp Tyr  Thr Gly Lys Lys Ser  Phe Val Arg 
    1505                 1510                 1515             


Thr His  Leu Gln Val Ile Ile  Ser Val Ser Gln Leu  Ile Ala Asp 
    1520                 1525                 1530             


Val Val  Gly Ile Gly Gly Thr  Arg Phe Gln Gln Ser  Leu Ser Ile 
    1535                 1540                 1545             


Ile Asn  Asn Cys Ala Asn Ser  Asp Arg Leu Ile Lys  His Thr Ser 
    1550                 1555                 1560             


Phe Ser  Ser Asp Val Lys Asp  Leu Thr Lys Arg Ile  Arg Thr Val 
    1565                 1570                 1575             


Leu Met  Ala Thr Ala Gln Met  Lys Glu His Glu Asn  Asp Pro Glu 
    1580                 1585                 1590             


Met Leu  Val Asp Leu Gln Tyr  Ser Leu Ala Lys Ser  Tyr Ala Ser 
    1595                 1600                 1605             


Thr Pro  Glu Leu Arg Lys Thr  Trp Leu Asp Ser Met  Ala Arg Ile 
    1610                 1615                 1620             


His Val  Lys Asn Gly Asp Leu  Ser Glu Ala Ala Met  Cys Tyr Val 
    1625                 1630                 1635             


His Val  Thr Ala Leu Val Ala  Glu Tyr Leu Thr Arg  Lys Glu Ala 
    1640                 1645                 1650             


Val Gln  Trp Glu Pro Pro Leu  Leu Pro His Ser His  Ser Ala Cys 
    1655                 1660                 1665             


Leu Arg  Arg Ser Arg Gly Gly  Val Phe Arg Gln Gly  Cys Thr Ala 
    1670                 1675                 1680             


Phe Arg  Val Ile Thr Pro Asn  Ile Asp Glu Glu Ala  Ser Met Met 
    1685                 1690                 1695             


Glu Asp  Val Gly Met Gln Asp  Val His Phe Asn Glu  Asp Val Leu 
    1700                 1705                 1710             


Met Glu  Leu Leu Glu Gln Cys  Ala Asp Gly Leu Trp  Lys Ala Glu 
    1715                 1720                 1725             


Arg Tyr  Glu Leu Ile Ala Asp  Ile Tyr Lys Leu Ile  Ile Pro Ile 
    1730                 1735                 1740             


Tyr Glu  Lys Arg Arg Asp Phe  Glu Arg Leu Ala His  Leu Tyr Asp 
    1745                 1750                 1755             


Thr Leu  His Arg Ala Tyr Ser  Lys Val Thr Glu Val  Met His Ser 
    1760                 1765                 1770             


Gly Arg  Arg Leu Leu Gly Thr  Tyr Phe Arg Val Ala  Phe Phe Gly 
    1775                 1780                 1785             


Gln Ala  Ala Gln Tyr Gln Phe  Thr Asp Ser Glu Thr  Asp Val Glu 
    1790                 1795                 1800             


Gly Phe  Phe Glu Asp Glu Asp  Gly Lys Glu Tyr Ile  Tyr Lys Glu 
    1805                 1810                 1815             


Pro Lys  Leu Thr Pro Leu Ser  Glu Ile Ser Gln Arg  Leu Leu Lys 
    1820                 1825                 1830             


Leu Tyr  Ser Asp Lys Phe Gly  Ser Glu Asn Val Lys  Met Ile Gln 
    1835                 1840                 1845             


Asp Ser  Gly Lys Val Asn Pro  Lys Asp Leu Asp Ser  Lys Tyr Ala 
    1850                 1855                 1860             


Tyr Ile  Gln Val Thr His Val  Ile Pro Phe Phe Asp  Glu Lys Glu 
    1865                 1870                 1875             


Leu Gln  Glu Arg Lys Thr Glu  Phe Glu Arg Ser His  Asn Ile Arg 
    1880                 1885                 1890             


Arg Phe  Met Phe Glu Met Pro  Phe Thr Gln Thr Gly  Lys Arg Gln 
    1895                 1900                 1905             


Gly Gly  Val Glu Glu Gln Cys  Lys Arg Arg Thr Ile  Leu Thr Ala 
    1910                 1915                 1920             


Ile His  Cys Phe Pro Tyr Val  Lys Lys Arg Ile Pro  Val Met Tyr 
    1925                 1930                 1935             


Gln His  His Thr Asp Leu Asn  Pro Ile Glu Val Ala  Ile Asp Glu 
    1940                 1945                 1950             


Met Ser  Lys Lys Val Ala Glu  Leu Arg Gln Leu Cys  Ser Ser Ala 
    1955                 1960                 1965             


Glu Val  Asp Met Ile Lys Leu  Gln Leu Lys Leu Gln  Gly Ser Val 
    1970                 1975                 1980             


Ser Val  Gln Val Asn Ala Gly  Pro Leu Ala Tyr Ala  Arg Ala Phe 
    1985                 1990                 1995             


Leu Asp  Asp Thr Asn Thr Lys  Arg Tyr Pro Asp Asn  Lys Val Lys 
    2000                 2005                 2010             


Leu Leu  Lys Glu Val Phe Arg  Gln Phe Val Glu Ala  Cys Gly Gln 
    2015                 2020                 2025             


Ala Leu  Ala Val Asn Glu Arg  Leu Ile Lys Glu Asp  Gln Leu Glu 
    2030                 2035                 2040             


Tyr Gln  Glu Glu Met Lys Ala  Asn Tyr Arg Glu Met  Ala Lys Glu 
    2045                 2050                 2055             


Leu Ser  Glu Ile Met His Glu  Gln Leu Gly 
    2060                 2065             


<210>  682
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Thr Arg Gly Ala Arg Leu Arg Ser Asp Ala Arg Ala Gln Leu Asn 
1               5                   10                  15      


Gln Leu Ser Leu Asp Gly Gly Thr Gly Ser Gly Gln Lys Gly Lys Cys 
            20                  25                  30          


Glu Glu Phe Pro Ser Ser Leu Ser Ser Val Ser Pro Gly Leu Glu Ala 
        35                  40                  45              


Ala Ala Leu Leu Leu Ala Val Thr Met Asp Pro Leu Glu Thr Pro Ile 
    50                  55                  60                  


Lys Asp Gly Ile Leu Tyr Gln Gln His Val Lys Phe Gly Lys Lys Cys 
65                  70                  75                  80  


Trp Arg Lys Val Trp Ala Leu Leu Tyr Ala Gly Gly Pro Ser Gly Val 
                85                  90                  95      


Ala Arg Leu Glu Ser Trp Glu Val Arg Asp Gly Gly Leu Gly Ala Ala 
            100                 105                 110         


Gly Asp Arg Ser Ala Gly Pro Gly Arg Arg Gly Glu Arg Arg Val Ile 
        115                 120                 125             


Arg Leu Ala Asp Cys Val Ser Val Leu Pro Ala Asp Gly Glu Ser Cys 
    130                 135                 140                 


Pro Arg Asp Thr Gly Ala Phe Leu Leu Thr Thr Thr Glu Arg Ser His 
145                 150                 155                 160 


Leu Leu Ala Ala Gln His Arg Gln Ala Trp Met Gly Pro Ile Cys Gln 
                165                 170                 175     


Leu Ala Phe Pro Gly Thr Gly Glu Ala Ser Ser Gly Ser Thr Asp Ala 
            180                 185                 190         


Gln Ser Pro Lys Arg Gly Leu Val Pro Met Glu Glu Asn Ser Ile Tyr 
        195                 200                 205             


Ser Ser Trp Gln Glu Val Gly Glu Phe Pro Val Val Val Gln Arg Thr 
    210                 215                 220                 


Glu Ala Ala Thr Arg Cys Gln Leu Lys Gly Pro Ala Leu Leu Val Leu 
225                 230                 235                 240 


Gly Pro Asp Ala Ile Gln Leu Arg Glu Ala Lys Gly Thr Gln Ala Leu 
                245                 250                 255     


Tyr Ser Trp Pro Tyr His Phe Leu Arg Lys Phe Gly Ser Asp Lys Gly 
            260                 265                 270         


Val Phe Ser Phe Glu Ala Gly Arg Arg Cys His Ser Gly Glu Gly Leu 
        275                 280                 285             


Phe Ala Phe Ser Thr Pro Cys Ala Pro Asp Leu Cys Arg Ala Val Ala 
    290                 295                 300                 


Gly Ala Ile Ala Arg Gln Arg Glu Arg Leu Pro Glu Leu Thr Arg Pro 
305                 310                 315                 320 


Gln Pro Cys Pro Leu Pro Arg Ala Thr Ser Leu Pro Ser Leu Asp Thr 
                325                 330                 335     


Pro Gly Glu Leu Arg Glu Met Pro Pro Gly Pro Glu Pro Pro Thr Ser 
            340                 345                 350         


Arg Lys Met His Leu Ala Glu Pro Gly Pro Gln Ser Leu Pro Leu Leu 
        355                 360                 365             


Leu Gly Pro Glu Pro Asn Asp Leu Ala Ser Gly Leu Tyr Ala Ser Val 
    370                 375                 380                 


Cys Lys Arg Ala Ser Gly Pro Pro Gly Asn Glu His Leu Tyr Glu Asn 
385                 390                 395                 400 


Leu Cys Val Leu Glu Ala Ser Pro Thr Leu His Gly Gly Glu Pro Glu 
                405                 410                 415     


Pro His Glu Gly Pro Gly Ser Arg Ser Pro Thr Thr Ser Pro Ile Tyr 
            420                 425                 430         


His Asn Gly Gln Asp Leu Ser Trp Pro Gly Pro Ala Asn Asp Ser Thr 
        435                 440                 445             


Leu Glu Ala Gln Tyr Arg Arg Leu Leu Glu Leu Asp Gln Val Glu Gly 
    450                 455                 460                 


Thr Gly Arg Pro Asp Pro Gln Ala Gly Phe Lys Ala Lys Leu Val Thr 
465                 470                 475                 480 


Leu Leu Ser Arg Glu Arg Arg Lys Gly Pro Ala Pro Cys Asp Arg Pro 
                485                 490                 495     


<210>  683
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  683

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
                245                 250                 255     


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
            260                 265                 270         


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
        275                 280                 285             


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
    290                 295                 300                 


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
305                 310                 315                 320 


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His 
                325                 330                 335     


Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr 
            340                 345                 350         


Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr 
        355                 360                 365             


Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu 
    370                 375                 380                 


Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val 
385                 390                 395                 400 


Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys 
                405                 410                 415     


Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg 
            420                 425                 430         


Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile 
        435                 440                 445             


Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu 
    450                 455                 460                 


Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro 
465                 470                 475                 480 


Val Leu Ile Leu Trp Leu 
                485     


<210>  684
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Ala Ala Val Val Glu Asn Val Val Lys Leu Leu Gly Glu Gln Tyr 
1               5                   10                  15      


Tyr Lys Asp Ala Met Glu Gln Cys His Asn Tyr Asn Ala Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Ser Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Ser Gly Gln Leu Tyr Ser Tyr Pro Ala Arg Arg Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Ala His Pro Pro Glu Asp Pro Arg Leu Ser Phe Pro 
                85                  90                  95      


Ser Ile Lys Pro Asp Thr Asp Gln Thr Leu Lys Lys Glu Gly Leu Ile 
            100                 105                 110         


Ser Gln Asp Gly Ser Ser Leu Glu Ala Leu Leu Arg Thr Asp Pro Leu 
        115                 120                 125             


Glu Lys Arg Gly Ala Pro Asp Pro Arg Val Asp Asp Asp Ser Leu Gly 
    130                 135                 140                 


Glu Phe Pro Val Thr Asn Ser Arg Ala Arg Lys Arg Ile Leu Glu Pro 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Leu Asp Asp Glu Asp Tyr Glu Glu Asp Thr 
                165                 170                 175     


Pro Lys Arg Arg Gly Lys Gly Lys Ser Lys Gly Lys Gly Val Gly Ser 
            180                 185                 190         


Ala Arg Lys Lys Leu Asp Ala Ser Ile Leu Glu Asp Arg Asp Lys Pro 
        195                 200                 205             


Tyr Ala Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu 
    210                 215                 220                 


Ser Tyr His Tyr Ala His Ser His Leu Ala Glu Glu Glu Gly Glu Asp 
225                 230                 235                 240 


Lys Glu Asp Ser Gln Pro Pro Thr Pro Val Ser Gln Arg Ser Glu Glu 
                245                 250                 255     


Gln Lys Ser Lys Lys Gly Pro Asp Gly Leu Ala Leu Pro Asn Asn Tyr 
            260                 265                 270         


Cys Asp Phe Cys Leu Gly Asp Ser Lys Ile Asn Lys Lys Thr Gly Gln 
        275                 280                 285             


Pro Glu Glu Leu Val Ser Cys Ser Asp Cys Gly Arg Ser Gly His Pro 
    290                 295                 300                 


Ser Cys Leu Gln Phe Thr Pro Val Met Met Ala Ala Val Lys Thr Tyr 
305                 310                 315                 320 


Arg Trp Gln Cys Ile Glu Cys Lys Cys Cys Asn Ile Cys Gly Thr Ser 
                325                 330                 335     


Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr 
            340                 345                 350         


His Met Tyr Cys Leu Thr Pro Ser Met Ser Glu Pro Pro Glu Gly Ser 
        355                 360                 365             


Trp Ser Cys His Leu Cys Leu Asp Leu Leu Lys Glu Lys Ala Ser Ile 
    370                 375                 380                 


Tyr Gln Asn Gln Asn Ser Ser 
385                 390     


<210>  685
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  685

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  686
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser 
1               5                   10                  15      


Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly 
            20                  25                  30          


Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys 
        35                  40                  45              


Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln 
    50                  55                  60                  


Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn 
65                  70                  75                  80  


Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu 
                85                  90                  95      


Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile 
            100                 105                 110         


Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe 
        115                 120                 125             


Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile 
    130                 135                 140                 


Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val 
                165                 170                 175     


Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile 
            180                 185                 190         


Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser 
        195                 200                 205             


His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val 
    210                 215                 220                 


Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly 
225                 230                 235                 240 


Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp 
                245                 250                 255     


Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln 
            260                 265                 270         


Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg 
        275                 280                 285             


Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu 
    290                 295                 300                 


Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala 
305                 310                 315                 320 


Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln 
                325                 330                 335     


Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
            340                 345                 350         


<210>  687
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  687

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
465                 470                 475                 480 


Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala 
                485                 490                 495     


Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr Ile Cys 
            500                 505                 510         


Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp 
        515                 520                 525             


Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met Gly Leu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu 
545                 550                 555                 560 


Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser 
                565                 570                 575     


Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln 
            580                 585                 590         


Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu His Tyr 
        595                 600                 605             


Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu Tyr Leu 
    610                 615                 620                 


Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn 
625                 630                 635                 640 


Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala 
                645                 650                 655     


Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Thr 
            660                 665                 670         


Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe 
        675                 680                 685             


Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu 
    690                 695                 700                 


Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu 
705                 710                 715                 720 


Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala 
                725                 730                 735     


Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu Gln Val 
            740                 745                 750         


Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser 
        755                 760                 765             


Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln 
    770                 775                 780                 


Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys 
785                 790                 795                 800 


Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala Asp Thr 
                805                 810                 815     


Ser Lys Pro Ser Thr Val Asn 
            820             


<210>  688
<211>  1371
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Thr Thr Lys Arg Ser Leu Phe Val Arg Leu Val Pro Cys Arg Cys 
1               5                   10                  15      


Leu Arg Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys 
            20                  25                  30          


Ser Leu Glu Gln Val Pro Lys Glu Ile Phe Thr Phe Glu Lys Thr Leu 
        35                  40                  45              


Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln 
    50                  55                  60                  


Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp 
65                  70                  75                  80  


Leu Thr Thr Leu Pro Ala Ser Ile Ala Asn Leu Ile Asn Leu Arg Glu 
                85                  90                  95      


Leu Asp Val Ser Lys Asn Gly Ile Gln Glu Phe Pro Glu Asn Ile Lys 
            100                 105                 110         


Asn Cys Lys Val Leu Thr Ile Val Glu Ala Ser Val Asn Pro Ile Ser 
        115                 120                 125             


Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr 
    130                 135                 140                 


Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu 
145                 150                 155                 160 


Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu 
                165                 170                 175     


Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly 
            180                 185                 190         


Ser Asn Glu Phe Thr Glu Val Pro Glu Val Leu Glu Gln Leu Ser Gly 
        195                 200                 205             


Leu Lys Glu Phe Trp Met Asp Ala Asn Arg Leu Thr Phe Ile Pro Gly 
    210                 215                 220                 


Phe Ile Gly Ser Leu Lys Gln Leu Thr Tyr Leu Asp Val Ser Lys Asn 
225                 230                 235                 240 


Asn Ile Glu Met Val Glu Glu Gly Ile Ser Thr Cys Glu Asn Leu Gln 
                245                 250                 255     


Asp Leu Leu Leu Ser Ser Asn Ser Leu Gln Gln Leu Pro Glu Thr Ile 
            260                 265                 270         


Gly Ser Leu Lys Asn Ile Thr Thr Leu Lys Ile Asp Glu Asn Gln Leu 
        275                 280                 285             


Met Tyr Leu Pro Asp Ser Ile Gly Gly Leu Ile Ser Val Glu Glu Leu 
    290                 295                 300                 


Asp Cys Ser Phe Asn Glu Val Glu Ala Leu Pro Ser Ser Ile Gly Gln 
305                 310                 315                 320 


Leu Thr Asn Leu Arg Thr Phe Ala Ala Asp His Asn Tyr Leu Gln Gln 
                325                 330                 335     


Leu Pro Pro Glu Ile Gly Ser Trp Lys Asn Ile Thr Val Leu Phe Leu 
            340                 345                 350         


His Ser Asn Lys Leu Glu Thr Leu Pro Glu Glu Met Gly Asp Met Gln 
        355                 360                 365             


Lys Leu Lys Val Ile Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro 
    370                 375                 380                 


Phe Ser Phe Thr Lys Leu Gln Gln Leu Thr Ala Met Trp Leu Ser Asp 
385                 390                 395                 400 


Asn Gln Ser Lys Pro Leu Ile Pro Leu Gln Lys Glu Thr Asp Ser Glu 
                405                 410                 415     


Thr Gln Lys Met Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg 
            420                 425                 430         


Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro Ser 
        435                 440                 445             


Leu Trp Glu Glu Gln Arg Lys Gln Arg Ala Gln Val Ala Phe Glu Cys 
    450                 455                 460                 


Asp Glu Asp Lys Asp Glu Arg Glu Ala Pro Pro Arg Glu Gly Asn Leu 
465                 470                 475                 480 


Lys Arg Tyr Pro Thr Pro Tyr Pro Asp Glu Leu Lys Asn Met Val Lys 
                485                 490                 495     


Thr Val Gln Thr Ile Val His Arg Leu Lys Asp Glu Glu Thr Asn Glu 
            500                 505                 510         


Asp Ser Gly Arg Asp Leu Lys Pro His Glu Asp Gln Gln Asp Ile Asn 
        515                 520                 525             


Lys Asp Val Gly Val Lys Thr Ser Glu Ser Thr Thr Thr Val Lys Ser 
    530                 535                 540                 


Lys Val Asp Glu Arg Glu Lys Tyr Met Ile Gly Asn Ser Val Gln Lys 
545                 550                 555                 560 


Ile Ser Glu Pro Glu Ala Glu Ile Ser Pro Gly Ser Leu Pro Val Thr 
                565                 570                 575     


Ala Asn Met Lys Ala Ser Glu Asn Leu Lys His Ile Val Asn His Asp 
            580                 585                 590         


Asp Val Phe Glu Glu Ser Glu Glu Leu Ser Ser Asp Glu Glu Met Lys 
        595                 600                 605             


Met Ala Glu Met Arg Pro Pro Leu Ile Glu Thr Ser Ile Asn Gln Pro 
    610                 615                 620                 


Lys Val Val Ala Leu Ser Asn Asn Lys Lys Asp Asp Thr Lys Glu Thr 
625                 630                 635                 640 


Asp Ser Leu Ser Asp Glu Val Thr His Asn Ser Asn Gln Asn Asn Ser 
                645                 650                 655     


Asn Cys Ser Ser Pro Ser Arg Met Ser Asp Ser Val Ser Leu Asn Thr 
            660                 665                 670         


Asp Ser Ser Gln Asp Thr Ser Leu Cys Ser Pro Val Lys Gln Thr His 
        675                 680                 685             


Ile Asp Ile Asn Ser Lys Ile Arg Gln Glu Asp Glu Asn Phe Asn Ser 
    690                 695                 700                 


Leu Leu Gln Asn Gly Asp Ile Leu Asn Ser Ser Thr Glu Glu Lys Phe 
705                 710                 715                 720 


Lys Ala His Asp Lys Lys Asp Phe Asn Leu Pro Glu Tyr Asp Leu Asn 
                725                 730                 735     


Val Glu Glu Arg Leu Val Leu Ile Glu Lys Ser Val Asp Ser Thr Ala 
            740                 745                 750         


Thr Ala Asp Asp Thr His Lys Leu Asp His Ile Asn Met Asn Leu Asn 
        755                 760                 765             


Lys Leu Ile Thr Asn Asp Thr Phe Gln Pro Glu Ile Met Glu Arg Ser 
    770                 775                 780                 


Lys Thr Gln Asp Ile Val Leu Gly Thr Ser Phe Leu Ser Ile Asn Ser 
785                 790                 795                 800 


Lys Glu Glu Thr Glu His Leu Glu Asn Gly Asn Lys Tyr Pro Asn Leu 
                805                 810                 815     


Glu Ser Val Asn Lys Val Asn Gly His Ser Glu Glu Thr Ser Gln Ser 
            820                 825                 830         


Pro Asn Arg Thr Glu Pro His Asp Ser Asp Cys Ser Val Asp Leu Gly 
        835                 840                 845             


Ile Ser Lys Ser Thr Glu Asp Leu Ser Pro Gln Lys Ser Gly Pro Val 
    850                 855                 860                 


Gly Ser Val Val Lys Ser His Ser Ile Thr Asn Met Glu Ile Gly Gly 
865                 870                 875                 880 


Leu Lys Ile Tyr Asp Ile Leu Ser Asp Asn Gly Pro Gln Gln Pro Ser 
                885                 890                 895     


Thr Thr Val Lys Ile Thr Ser Ala Val Asp Gly Lys Asn Ile Val Arg 
            900                 905                 910         


Ser Lys Ser Ala Thr Leu Leu Tyr Asp Gln Pro Leu Gln Val Phe Thr 
        915                 920                 925             


Gly Ser Ser Ser Ser Ser Asp Leu Ile Ser Gly Thr Lys Ala Ile Phe 
    930                 935                 940                 


Lys Phe Asp Ser Asn His Asn Pro Glu Glu Pro Asn Ile Ile Arg Gly 
945                 950                 955                 960 


Pro Thr Ser Gly Pro Gln Ser Ala Pro Gln Ile Tyr Gly Pro Pro Gln 
                965                 970                 975     


Tyr Asn Ile Gln Tyr Ser Ser Ser Ala Ala Val Lys Asp Thr Leu Trp 
            980                 985                 990         


His Ser Lys Gln Asn Pro Gln Ile  Asp His Ala Ser Phe  Pro Pro Gln 
        995                 1000                 1005             


Leu Leu  Pro Arg Ser Glu Ser  Thr Glu Asn Gln Ser  Tyr Ala Lys 
    1010                 1015                 1020             


His Ser  Ala Asn Met Asn Phe  Ser Asn His Asn Asn  Val Arg Ala 
    1025                 1030                 1035             


Asn Thr  Ala Tyr His Leu His  Gln Arg Leu Gly Pro  Ala Arg His 
    1040                 1045                 1050             


Gly Glu  Met Trp Ala Ile Ser  Pro Asn Asp Arg Leu  Ile Pro Ala 
    1055                 1060                 1065             


Val Thr  Arg Ser Thr Ile Gln  Arg Gln Ser Ser Val  Ser Ser Thr 
    1070                 1075                 1080             


Ala Ser  Val Asn Leu Gly Asp  Pro Gly Ser Thr Arg  Arg Ala Gln 
    1085                 1090                 1095             


Ile Pro  Glu Gly Asp Tyr Leu  Ser Tyr Arg Glu Phe  His Ser Ala 
    1100                 1105                 1110             


Gly Arg  Thr Pro Pro Met Met  Pro Gly Ser Gln Arg  Pro Leu Ser 
    1115                 1120                 1125             


Ala Arg  Thr Tyr Ser Ile Asp  Gly Pro Asn Ala Ser  Arg Pro Gln 
    1130                 1135                 1140             


Ser Ala  Arg Pro Ser Ile Asn  Glu Ile Pro Glu Arg  Thr Met Ser 
    1145                 1150                 1155             


Val Ser  Asp Phe Asn Tyr Ser  Arg Thr Ser Pro Ser  Lys Arg Pro 
    1160                 1165                 1170             


Asn Ala  Arg Val Gly Ser Glu  His Ser Leu Leu Asp  Pro Pro Gly 
    1175                 1180                 1185             


Lys Ser  Lys Val Pro Arg Asp  Trp Arg Glu Gln Val  Leu Arg His 
    1190                 1195                 1200             


Ile Glu  Ala Lys Lys Leu Glu  Lys Met Pro Leu Ser  Asn Gly Gln 
    1205                 1210                 1215             


Met Gly  Gln Pro Leu Arg Pro  Gln Ala Asn Tyr Ser  Gln Ile His 
    1220                 1225                 1230             


His Pro  Pro Gln Ala Ser Val  Ala Arg His Pro Ser  Arg Glu Gln 
    1235                 1240                 1245             


Leu Ile  Asp Tyr Leu Met Leu  Lys Val Ala His Gln  Pro Pro Tyr 
    1250                 1255                 1260             


Thr Gln  Pro His Cys Ser Pro  Arg Gln Gly His Glu  Leu Ala Lys 
    1265                 1270                 1275             


Gln Glu  Ile Arg Val Arg Val  Glu Lys Asp Pro Glu  Leu Gly Phe 
    1280                 1285                 1290             


Ser Ile  Ser Gly Gly Val Gly  Gly Arg Gly Asn Pro  Phe Arg Pro 
    1295                 1300                 1305             


Asp Asp  Asp Gly Ile Phe Val  Thr Arg Val Gln Pro  Glu Gly Pro 
    1310                 1315                 1320             


Ala Ser  Lys Leu Leu Gln Pro  Gly Asp Lys Ile Ile  Gln Ala Asn 
    1325                 1330                 1335             


Gly Tyr  Ser Phe Ile Asn Ile  Glu His Gly Gln Ala  Val Ser Leu 
    1340                 1345                 1350             


Leu Lys  Thr Phe Gln Asn Thr  Val Glu Leu Ile Ile  Val Arg Glu 
    1355                 1360                 1365             


Val Ser  Ser 
    1370     


<210>  689
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  689

Met Asn Asp Phe Gly Ile Lys Asn Met Asp Gln Val Ala Pro Val Ala 
1               5                   10                  15      


Asn Ser Tyr Arg Gly Thr Leu Lys Arg Gln Pro Ala Phe Asp Thr Phe 
            20                  25                  30          


Asp Gly Ser Leu Phe Ala Val Phe Pro Ser Leu Asn Glu Glu Gln Thr 
        35                  40                  45              


Leu Gln Glu Val Pro Thr Gly Leu Asp Ser Ile Ser His Asp Ser Ala 
    50                  55                  60                  


Asn Cys Glu Leu Pro Leu Leu Thr Pro Cys Ser Lys Ala Val Met Ser 
65                  70                  75                  80  


Gln Ala Leu Lys Ala Thr Phe Ser Gly Phe Lys Lys Glu Gln Arg Arg 
                85                  90                  95      


Leu Gly Ile Pro Lys Asn Pro Trp Leu Trp Ser Glu Gln Gln Val Cys 
            100                 105                 110         


Gln Trp Leu Leu Trp Ala Thr Asn Glu Phe Ser Leu Val Asn Val Asn 
        115                 120                 125             


Leu Gln Arg Phe Gly Met Asn Gly Gln Met Leu Cys Asn Leu Gly Lys 
    130                 135                 140                 


Glu Arg Phe Leu Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp 
145                 150                 155                 160 


Glu His Leu Glu Gln Met Ile Lys Glu Asn Gln Glu Lys Thr Glu Asp 
                165                 170                 175     


Gln Tyr Glu Glu Asn Ser His Leu Thr Ser Val Pro His Trp Ile Asn 
            180                 185                 190         


Ser Asn Thr Leu Gly Phe Gly Thr Glu Gln Ala Pro Tyr Gly Met Gln 
        195                 200                 205             


Thr Gln Asn Tyr Pro Lys Gly Gly Leu Leu Asp Ser Met Cys Pro Ala 
    210                 215                 220                 


Ser Thr Pro Ser Val Leu Ser Ser Glu Gln Glu Phe Gln Met Phe Pro 
225                 230                 235                 240 


Lys Ser Arg Leu Ser Ser Val Ser Val Thr Tyr Cys Ser Val Ser Gln 
                245                 250                 255     


Asp Phe Pro Gly Ser Asn Leu Asn Leu Leu Thr Asn Asn Ser Gly Thr 
            260                 265                 270         


Pro Lys Asp His Asp Ser Pro Glu Asn Gly Ala Asp Ser Phe Glu Ser 
        275                 280                 285             


Ser Asp Ser Leu Leu Gln Ser Trp Asn Ser Gln Ser Ser Leu Leu Asp 
    290                 295                 300                 


Val Gln Arg Val Pro Ser Phe Glu Ser Phe Glu Asp Asp Cys Ser Gln 
305                 310                 315                 320 


Ser Leu Cys Leu Asn Lys Pro Thr Met Ser Phe Lys Asp Tyr Ile Gln 
                325                 330                 335     


Glu Arg Ser Asp Pro Val Glu Gln Gly Lys Pro Val Ile Pro Ala Ala 
            340                 345                 350         


Val Leu Ala Gly Phe Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe 
        355                 360                 365             


Leu Leu Glu Leu Leu Ser Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp 
    370                 375                 380                 


Thr Gly Asp Gly Trp Glu Phe Lys Leu Ala Asp Pro Asp Glu Val Ala 
385                 390                 395                 400 


Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys 
                405                 410                 415     


Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys 
            420                 425                 430         


Thr Ser Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Asn 
        435                 440                 445             


Leu Leu Gly Phe Thr Pro Glu Glu Leu His Ala Ile Leu Gly Val Gln 
    450                 455                 460                 


Pro Asp Thr Glu Asp 
465                 


<210>  690
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
225                 230                 235                 240 


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
                245                 250                 255     


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
            260                 265                 270         


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
        275                 280                 285             


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
    290                 295                 300                 


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
305                 310                 315                 320 


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
                325                 330                 335     


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
            340                 345                 350         


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
        355                 360                 365             


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
    370                 375                 380                 


Tyr Ile Asn Val Pro Ala 
385                 390 


<210>  691
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  691

Met Ala Ser Gly Gly Gly Gly Gly Asn Thr Gly Ala Gly Gly Gly Pro 
1               5                   10                  15      


Gly Met Gly Leu Ser Leu Gly Leu Gly Leu Gly Leu Ser Leu Gly Met 
            20                  25                  30          


Ser Glu Ala Thr Ser Glu Ala Glu Glu Glu Ala Ala Thr Ala Glu Ala 
        35                  40                  45              


Val Gly Arg Leu Ala Thr Thr Leu Trp Leu Arg Leu Arg Gly Trp Glu 
    50                  55                  60                  


Ala Val Leu Ala Ala Ala Gln Arg Leu Leu Val Trp Glu Lys Pro Leu 
65                  70                  75                  80  


His Ser Leu Val Thr Ala Ala Ala Leu Asn Gly Leu Phe Trp Leu Leu 
                85                  90                  95      


Ser Ser Ser Ser Leu Arg Pro Phe Phe Leu Leu Ser Val Ser Leu Leu 
            100                 105                 110         


Ala Tyr Phe Leu Leu Asp Leu Trp Gln Pro Arg Phe Leu Pro Asp Val 
        115                 120                 125             


Ser Ala Ser Ser Pro Glu Glu Pro His Ser Asp Ser Glu Gly Ala Gly 
    130                 135                 140                 


Ser Gly Ala Arg Pro His Leu Leu Ser Val Pro Glu Leu Cys Arg Tyr 
145                 150                 155                 160 


Leu Ala Glu Ser Trp Leu Thr Phe Gln Ile His Leu Gln Glu Leu Leu 
                165                 170                 175     


Gln Tyr Lys Arg Gln Asn Pro Ala Gln Phe Cys Val Arg Val Cys Ser 
            180                 185                 190         


Gly Cys Ala Val Leu Ala Val Leu Gly His Tyr Val Pro Gly Ile Met 
        195                 200                 205             


Ile Ser Tyr Ile Val Leu Leu Ser Ile Leu Leu Trp Pro Leu Val Val 
    210                 215                 220                 


Tyr His Glu Leu Ile Gln Arg Met Tyr Thr Arg Leu Glu Pro Leu Leu 
225                 230                 235                 240 


Met Gln Leu Asp Tyr Ser Met Lys Ala Glu Ala Asn Ala Leu His His 
                245                 250                 255     


Lys His Asp Lys Arg Lys Arg Gln Gly Lys Asn Ala Pro Pro Gly Gly 
            260                 265                 270         


Asp Glu Pro Leu Ala Glu Thr Glu Ser Glu Ser Glu Ala Glu Leu Ala 
        275                 280                 285             


Gly Phe Ser Pro Val Val Asp Val Lys Lys Thr Ala Leu Ala Leu Ala 
    290                 295                 300                 


Ile Thr Asp Ser Glu Leu Ser Asp Glu Glu Ala Ser Ile Leu Glu Ser 
305                 310                 315                 320 


Gly Gly Phe Ser Val Ser Arg Ala Thr Thr Pro Gln Leu Thr Asp Val 
                325                 330                 335     


Ser Glu Asp Leu Asp Gln Gln Ser Leu Pro Ser Glu Pro Glu Glu Thr 
            340                 345                 350         


Leu Ser Arg Asp Leu Gly Glu Gly Glu Glu Gly Glu Leu Ala Pro Pro 
        355                 360                 365             


Glu Asp Leu Leu Gly Arg Pro Gln Ala Leu Ser Arg Gln Ala Leu Asp 
    370                 375                 380                 


Ser Glu Glu Glu Glu Glu Asp Val Ala Ala Lys Glu Thr Leu Leu Arg 
385                 390                 395                 400 


Leu Ser Ser Pro Leu His Phe Val Asn Thr His Phe Asn Gly Ala Gly 
                405                 410                 415     


Ser Pro Pro Asp Gly Val Lys Cys Ser Pro Gly Gly Pro Val Glu Thr 
            420                 425                 430         


Leu Ser Pro Glu Thr Val Ser Gly Gly Leu Thr Ala Leu Pro Gly Thr 
        435                 440                 445             


Leu Ser Pro Pro Leu Cys Leu Val Gly Ser Asp Pro Ala Pro Ser Pro 
    450                 455                 460                 


Ser Ile Leu Pro Pro Val Pro Gln Asp Ser Pro Gln Pro Leu Pro Ala 
465                 470                 475                 480 


Pro Glu Glu Glu Glu Ala Leu Thr Thr Glu Asp Phe Glu Leu Leu Asp 
                485                 490                 495     


Gln Gly Glu Leu Glu Gln Leu Asn Ala Glu Leu Gly Leu Glu Pro Glu 
            500                 505                 510         


Thr Pro Pro Lys Pro Pro Asp Ala Pro Pro Leu Gly Pro Asp Ile His 
        515                 520                 525             


Ser Leu Val Gln Ser Asp Gln Glu Ala Gln Ala Val Ala Glu Pro 
    530                 535                 540             


<210>  692
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Leu Val Gly Ser Gln Ser Phe Ser Pro Gly Gly Pro Asn Gly Ile 
1               5                   10                  15      


Ile Arg Ser Gln Ser Phe Ala Gly Phe Ser Gly Leu Gln Glu Arg Arg 
            20                  25                  30          


Ser Arg Cys Asn Ser Phe Ile Glu Asn Ser Ser Ala Leu Lys Lys Pro 
        35                  40                  45              


Gln Ala Lys Leu Lys Lys Met His Asn Leu Gly His Lys Asn Asn Asn 
    50                  55                  60                  


Pro Pro Lys Glu Pro Gln Pro Lys Arg Val Glu Glu Val Tyr Arg Ala 
65                  70                  75                  80  


Leu Lys Asn Gly Leu Asp Glu Tyr Leu Glu Val His Gln Thr Glu Leu 
                85                  90                  95      


Asp Lys Leu Thr Ala Gln Leu Lys Asp Met Lys Arg Asn Ser Arg Leu 
            100                 105                 110         


Gly Val Leu Tyr Asp Leu Asp Lys Gln Ile Lys Thr Ile Glu Arg Tyr 
        115                 120                 125             


Met Arg Arg Leu Glu Phe His Ile Ser Lys Val Asp Glu Leu Tyr Glu 
    130                 135                 140                 


Ala Tyr Cys Ile Gln Arg Arg Leu Gln Asp Gly Ala Ser Lys Met Lys 
145                 150                 155                 160 


Gln Ala Phe Ala Thr Ser Pro Ala Ser Lys Ala Ala Arg Glu Ser Leu 
                165                 170                 175     


Thr Glu Ile Asn Arg Ser Phe Lys Glu Tyr Thr Glu Asn Met Cys Thr 
            180                 185                 190         


Ile Glu Val Glu Leu Glu Asn Leu Leu Gly Glu Phe Ser Ile Lys Met 
        195                 200                 205             


Lys Gly Leu Ala Gly Phe Ala Arg Leu Cys Pro Gly Asp Gln Tyr Glu 
    210                 215                 220                 


Ile Phe Met Lys Tyr Gly Arg Gln Arg Trp Lys Leu Lys Gly Lys Ile 
225                 230                 235                 240 


Glu Val Asn Gly Lys Gln Ser Trp Asp Gly Glu Glu Thr Val Phe Leu 
                245                 250                 255     


Pro Leu Ile Val Gly Phe Ile Ser Ile Lys Val Thr Glu Leu Lys Gly 
            260                 265                 270         


Leu Ala Thr His Ile Leu Val Gly Ser Val Thr Cys Glu Thr Lys Glu 
        275                 280                 285             


Leu Phe Ala Ala Arg Pro Gln Val Val Ala Val Asp Ile Asn Asp Leu 
    290                 295                 300                 


Gly Thr Ile Lys Leu Asn Leu Glu Ile Thr Trp Tyr Pro Phe Asp Val 
305                 310                 315                 320 


Glu Asp Met Thr Ala Ser Ser Gly Ala Gly Asn Lys Ala Ala Ala Leu 
                325                 330                 335     


Gln Arg Arg Met Ser Met Tyr Ser Gln Gly Thr Pro Glu Thr Pro Thr 
            340                 345                 350         


Phe Lys Asp His Ser Phe Phe Arg Trp Leu His Pro Ser Pro Asp Lys 
        355                 360                 365             


Pro Arg Arg Leu Ser Val Leu Ser Ala Leu Gln Asp Thr Phe Phe Ala 
    370                 375                 380                 


Lys Leu His Arg Ser Arg Ser Phe Ser Asp Leu Pro Ser Leu Arg Pro 
385                 390                 395                 400 


Ser Pro Lys Ala Val Leu Glu Leu Tyr Ser Asn Leu Pro Asp Asp Ile 
                405                 410                 415     


Phe Glu Asn Gly Lys Ala Ala Glu Glu Lys Met Pro Leu Ser Leu Ser 
            420                 425                 430         


Phe Ser Asp Leu Pro Asn Gly Asp Cys Ala Leu Thr Ser His Ser Thr 
        435                 440                 445             


Gly Ser Pro Ser Asn Ser Thr Asn Pro Glu Ile Thr Ile Thr Pro Ala 
    450                 455                 460                 


Glu Phe Asn Leu Ser Ser Leu Ala Ser Gln Asn Glu Gly Met Asp Asp 
465                 470                 475                 480 


Thr Ser Ser Ala Ser Ser Arg Asn Ser Leu Gly Glu Gly Gln Glu Pro 
                485                 490                 495     


Lys Ser His Leu Lys Glu Glu Asp Pro Glu Glu Pro Arg Lys Pro Ala 
            500                 505                 510         


Ser Ala Pro Ser Glu Ala Cys Arg Arg Gln Ser Ser Gly Ala Gly Ala 
        515                 520                 525             


Glu His Leu Phe Leu Glu Asn Asp Val Ala Glu Ala Leu Leu Gln Glu 
    530                 535                 540                 


Ser Glu Glu Ala Ser Glu Leu Lys Pro Val Glu Leu Asp Thr Ser Glu 
545                 550                 555                 560 


Gly Asn Ile Thr Lys Gln Leu Val Lys Arg Leu Thr Ser Ala Glu Val 
                565                 570                 575     


Pro Met Ala Thr Asp Arg Leu Leu Ser Glu Gly Ser Val Gly Gly Glu 
            580                 585                 590         


Ser Glu Gly Cys Arg Ser Phe Leu Asp Gly Ser Leu Glu Asp Ala Phe 
        595                 600                 605             


Asn Gly Leu Leu Leu Ala Leu Glu Pro His Lys Glu Gln Tyr Lys Glu 
    610                 615                 620                 


Phe Gln Asp Leu Asn Gln Glu Val Met Asn Leu Asp Asp Ile Leu Lys 
625                 630                 635                 640 


Cys Lys Pro Ala Val Ser Arg Ser Arg Ser Ser Ser Leu Ser Leu Thr 
                645                 650                 655     


Val Glu Ser Ala Leu Glu Ser Phe Asp Phe Leu Asn Thr Ser Asp Phe 
            660                 665                 670         


Asp Glu Glu Glu Asp Gly Asp Glu Val Cys Asn Val Gly Gly Gly Ala 
        675                 680                 685             


Asp Ser Val Phe Ser Asp Thr Glu Thr Glu Lys His Ser Tyr Arg Ser 
    690                 695                 700                 


Val His Pro Glu Ala Arg Gly His Leu Ser Glu Ala Leu Thr Glu Asp 
705                 710                 715                 720 


Thr Gly Val Gly Thr Ser Val Ala Gly Ser Pro Leu Pro Leu Thr Thr 
                725                 730                 735     


Gly Asn Glu Ser Leu Asp Ile Thr Ile Val Arg His Leu Gln Tyr Cys 
            740                 745                 750         


Thr Gln Leu Val Gln Gln Ile Val Phe Ser Ser Lys Thr Pro Phe Val 
        755                 760                 765             


Ala Arg Ser Leu Leu Glu Lys Leu Ser Arg Gln Ile Gln Val Met Glu 
    770                 775                 780                 


Lys Leu Ala Ala Val Ser Asp Glu Asn Ile Gly Asn Ile Ser Ser Val 
785                 790                 795                 800 


Val Glu Ala Ile Pro Glu Phe His Lys Lys Leu Ser Leu Leu Ser Phe 
                805                 810                 815     


Trp Thr Lys Cys Cys Ser Pro Val Gly Val Tyr His Ser Pro Ala Asp 
            820                 825                 830         


Arg Val Met Lys Gln Leu Glu Ala Ser Phe Ala Arg Thr Val Asn Lys 
        835                 840                 845             


Glu Tyr Pro Gly Leu Ala Asp Pro Val Phe Arg Thr Leu Val Ser Gln 
    850                 855                 860                 


Ile Leu Asp Arg Ala Glu Pro Leu Leu Ser Ser Ser Leu Ser Ser Glu 
865                 870                 875                 880 


Val Val Thr Val Phe Gln Tyr Tyr Ser Tyr Phe Thr Ser His Gly Val 
                885                 890                 895     


Ser Asp Leu Glu Ser Tyr Leu Ser Gln Leu Ala Arg Gln Val Ser Met 
            900                 905                 910         


Val Gln Thr Leu Gln Ser Leu Arg Asp Glu Lys Leu Leu Gln Thr Met 
        915                 920                 925             


Ser Asp Leu Ala Pro Ser Asn Leu Leu Ala Gln Gln Glu Val Leu Arg 
    930                 935                 940                 


Thr Leu Ala Leu Leu Leu Thr Arg Glu Asp Asn Glu Val Ser Glu Ala 
945                 950                 955                 960 


Val Thr Leu Tyr Leu Ala Ala Ala Ser Lys Asn Gln His Phe Arg Glu 
                965                 970                 975     


Lys Ala Leu Leu Tyr Tyr Cys Glu Ala Leu Thr Lys Thr Asn Leu Gln 
            980                 985                 990         


Leu Gln Lys Ala Ala Cys Leu Ala  Leu Lys Ile Leu Glu  Ala Thr Glu 
        995                 1000                 1005             


Ser Ile  Lys Met Leu Val Thr  Leu Cys Gln Ser Asp  Thr Glu Glu 
    1010                 1015                 1020             


Ile Arg  Asn Val Ala Ser Glu  Thr Leu Leu Ser Leu  Gly Glu Asp 
    1025                 1030                 1035             


Gly Arg  Leu Ala Tyr Glu Gln  Leu Asp Lys Phe Pro  Arg Asp Cys 
    1040                 1045                 1050             


Val Lys  Val Gly Gly Arg His  Gly Thr Glu Val Ala  Thr Ala Phe 
    1055                 1060                 1065             


<210>  693
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  693

Met Val Ala Glu Glu Ser Gly Pro Gly Ala Gln Asn Ser Pro Tyr Gln 
1               5                   10                  15      


Leu Arg Arg Lys Thr Leu Leu Pro Lys Arg Thr Ala Cys Pro Thr Lys 
            20                  25                  30          


Asn Ser Met Glu Gly Ala Ser Thr Ser Thr Thr Glu Asn Phe Gly His 
        35                  40                  45              


Arg Ala Lys Arg Ala Arg Val Ser Gly Lys Ser Gln Asp Leu Ser Ala 
    50                  55                  60                  


Ala Pro Ala Glu Gln Tyr Leu Gln Glu Lys Leu Pro Asp Glu Val Val 
65                  70                  75                  80  


Leu Lys Ile Phe Ser Tyr Leu Leu Glu Gln Asp Leu Cys Arg Ala Ala 
                85                  90                  95      


Cys Val Cys Lys Arg Phe Ser Glu Leu Ala Asn Asp Pro Ile Leu Trp 
            100                 105                 110         


Lys Arg Leu Tyr Met Glu Val Phe Glu Tyr Thr Arg Pro Met Met His 
        115                 120                 125             


Pro Glu Pro Gly Lys Phe Tyr Gln Ile Asn Pro Glu Glu Tyr Glu His 
    130                 135                 140                 


Pro Asn Pro Trp Lys Glu Ser Phe Gln Gln Leu Tyr Lys Gly Ala His 
145                 150                 155                 160 


Val Lys Pro Gly Phe Ala Glu His Phe Tyr Ser Asn Pro Ala Arg Tyr 
                165                 170                 175     


Lys Gly Arg Glu Asn Met Leu Tyr Tyr Asp Thr Ile Glu Asp Ala Leu 
            180                 185                 190         


Gly Gly Val Gln Glu Ala His Phe Asp Gly Leu Ile Phe Val His Ser 
        195                 200                 205             


Gly Ile Tyr Thr Asp Glu Trp Ile Tyr Ile Glu Ser Pro Ile Thr Met 
    210                 215                 220                 


Ile Gly Ala Ala Pro Gly Lys Val Ala Asp Lys Val Ile Ile Glu Asn 
225                 230                 235                 240 


Thr Arg Asp Ser Thr Phe Val Phe Met Glu Gly Ser Glu Asp Ala Tyr 
                245                 250                 255     


Val Gly Tyr Met Thr Ile Arg Phe Asn Pro Asp Asp Lys Ser Ala Gln 
            260                 265                 270         


His His Asn Ala His His Cys Leu Glu Ile Thr Val Asn Cys Ser Pro 
        275                 280                 285             


Ile Ile Asp His Cys Ile Ile Arg Ser Thr Cys Thr Val Gly Ser Ala 
    290                 295                 300                 


Val Cys Val Ser Gly Gln Gly Ala Cys Pro Thr Ile Lys His Cys Asn 
305                 310                 315                 320 


Ile Ser Asp Cys Glu Asn Val Gly Leu Tyr Ile Thr Asp His Ala Gln 
                325                 330                 335     


Gly Ile Tyr Glu Asp Asn Glu Ile Ser Asn Asn Ala Leu Ala Gly Ile 
            340                 345                 350         


Trp Val Lys Asn His Gly Asn Pro Ile Ile Arg Arg Asn His Ile His 
        355                 360                 365             


His Gly Arg Asp Val Gly Val Phe Thr Phe Asp His Gly Met Gly Tyr 
    370                 375                 380                 


Phe Glu Ser Cys Asn Ile His Arg Asn Arg Ile Ala Gly Phe Glu Val 
385                 390                 395                 400 


Lys Ala Tyr Ala Asn Pro Thr Val Val Arg Cys Glu Ile His His Gly 
                405                 410                 415     


Gln Thr Gly Gly Ile Tyr Val His Glu Lys Gly Arg Gly Gln Phe Ile 
            420                 425                 430         


Glu Asn Lys Ile Tyr Ala Asn Asn Phe Ala Gly Val Trp Ile Thr Ser 
        435                 440                 445             


Asn Ser Asp Pro Thr Ile Arg Gly Asn Ser Ile Phe Asn Gly Asn Gln 
    450                 455                 460                 


Gly Gly Val Tyr Ile Phe Gly Asp Gly Arg Gly Leu Ile Glu Gly Asn 
465                 470                 475                 480 


Asp Ile Tyr Gly Asn Ala Leu Ala Gly Ile Gln Ile Arg Thr Asn Ser 
                485                 490                 495     


Cys Pro Ile Val Arg His Asn Lys Ile His Asp Gly Gln His Gly Gly 
            500                 505                 510         


Ile Tyr Val His Glu Lys Gly Gln Gly Val Ile Glu Glu Asn Glu Val 
        515                 520                 525             


Tyr Ser Asn Thr Leu Ala Gly Val Trp Val Thr Thr Gly Ser Thr Pro 
    530                 535                 540                 


Val Leu Arg Arg Asn Arg Ile His Ser Gly Lys Gln Val Gly Val Tyr 
545                 550                 555                 560 


Phe Tyr Asp Asn Gly His Gly Val Leu Glu Asp Asn Asp Ile Tyr Asn 
                565                 570                 575     


His Met Tyr Ser Gly Val Gln Ile Arg Thr Gly Ser Asn Pro Lys Ile 
            580                 585                 590         


Arg Arg Asn Lys Ile Trp Gly Gly Gln Asn Gly Gly Ile Leu Val Tyr 
        595                 600                 605             


Asn Ser Gly Leu Gly Cys Ile Glu Asp Asn Glu Ile Phe Asp Asn Ala 
    610                 615                 620                 


Met Ala Gly Val Trp Ile Lys Thr Asp Ser Asn Pro Thr Leu Arg Arg 
625                 630                 635                 640 


Asn Lys Ile His Asp Gly Arg Asp Gly Gly Ile Cys Ile Phe Asn Gly 
                645                 650                 655     


Gly Arg Gly Leu Leu Glu Glu Asn Asp Ile Phe Arg Asn Ala Gln Ala 
            660                 665                 670         


Gly Val Leu Ile Ser Thr Asn Ser His Pro Ile Leu Arg Lys Asn Arg 
        675                 680                 685             


Ile Phe Asp Gly Phe Ala Ala Gly Ile Glu Ile Thr Asn His Ala Thr 
    690                 695                 700                 


Ala Thr Leu Glu Gly Asn Gln Ile Phe Asn Asn Arg Phe Gly Gly Leu 
705                 710                 715                 720 


Phe Leu Ala Ser Gly Val Asn Val Thr Met Lys Asp Asn Lys Ile Met 
                725                 730                 735     


Asn Asn Gln Asp Ala Ile Glu Lys Ala Val Ser Arg Gly Gln Cys Leu 
            740                 745                 750         


Tyr Lys Ile Ser Ser Tyr Thr Ser Tyr Pro Met His Asp Phe Tyr Arg 
        755                 760                 765             


Cys His Thr Cys Asn Thr Thr Asp Arg Asn Ala Ile Cys Val Asn Cys 
    770                 775                 780                 


Ile Lys Lys Cys His Gln Gly His Asp Val Glu Phe Ile Arg His Asp 
785                 790                 795                 800 


Arg Phe Phe Cys Asp Cys Gly Ala Gly Thr Leu Ser Asn Pro Cys Thr 
                805                 810                 815     


Leu Ala Gly Glu Pro Thr His Asp Thr Asp Thr Leu Tyr Asp Ser Ala 
            820                 825                 830         


Pro Pro Ile Glu Ser Asn Thr Leu Gln His Asn 
        835                 840             


<210>  694
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Pro Asp Ile Ile Trp Val Phe Pro Pro Gln Ala Glu Ala Glu Glu 
1               5                   10                  15      


Asp Cys His Ser Asp Thr Val Arg Ala Asp Asp Asp Glu Glu Asn Glu 
            20                  25                  30          


Ser Pro Ala Glu Thr Asp Leu Gln Ala Gln Leu Gln Met Phe Arg Ala 
        35                  40                  45              


Gln Trp Met Phe Glu Leu Ala Pro Gly Val Ser Ser Ser Asn Leu Glu 
    50                  55                  60                  


Asn Arg Pro Cys Arg Ala Ala Arg Gly Ser Leu Gln Lys Thr Ser Ala 
65                  70                  75                  80  


Asp Thr Lys Gly Lys Gln Glu Gln Ala Lys Glu Glu Lys Ala Arg Glu 
                85                  90                  95      


Leu Phe Leu Lys Ala Val Glu Glu Glu Gln Asn Gly Ala Leu Tyr Glu 
            100                 105                 110         


Ala Ile Lys Phe Tyr Arg Arg Ala Met Gln Leu Val Pro Asp Ile Glu 
        115                 120                 125             


Phe Lys Ile Thr Tyr Thr Arg Ser Pro Asp Gly Asp Gly Val Gly Asn 
    130                 135                 140                 


Ser Tyr Ile Glu Asp Asn Asp Asp Asp Ser Lys Met Ala Asp Leu Leu 
145                 150                 155                 160 


Ser Tyr Phe Gln Gln Gln Leu Thr Phe Gln Glu Ser Val Leu Lys Leu 
                165                 170                 175     


Cys Gln Pro Glu Leu Glu Ser Ser Gln Ile His Ile Ser Val Leu Pro 
            180                 185                 190         


Met Glu Val Leu Met Tyr Ile Phe Arg Trp Val Val Ser Ser Asp Leu 
        195                 200                 205             


Asp Leu Arg Ser Leu Glu Gln Leu Ser Leu Val Cys Arg Gly Phe Tyr 
    210                 215                 220                 


Ile Cys Ala Arg Asp Pro Glu Ile Trp Arg Leu Ala Cys Leu Lys Val 
225                 230                 235                 240 


Trp Gly Arg Ser Cys Ile Lys Leu Val Pro Tyr Thr Ser Trp Arg Glu 
                245                 250                 255     


Met Phe Leu Glu Arg Pro Arg Val Arg Phe Asp Gly Val Tyr Ile Ser 
            260                 265                 270         


Lys Thr Thr Tyr Ile Arg Gln Gly Glu Gln Ser Leu Asp Gly Phe Tyr 
        275                 280                 285             


Arg Ala Trp His Gln Val Glu Tyr Tyr Arg Tyr Ile Arg Phe Phe Pro 
    290                 295                 300                 


Asp Gly His Val Met Met Leu Thr Thr Pro Glu Glu Pro Gln Ser Ile 
305                 310                 315                 320 


Val Pro Arg Leu Arg Thr Arg Asn Thr Arg Thr Asp Ala Ile Leu Leu 
                325                 330                 335     


Gly His Tyr Arg Leu Ser Gln Asp Thr Asp Asn Gln Thr Lys Val Phe 
            340                 345                 350         


Ala Val Ile Thr Lys Lys Lys Glu Glu Lys Pro Leu Asp Tyr Lys Tyr 
        355                 360                 365             


Arg Tyr Phe Arg Arg Val Pro Val Gln Glu Ala Asp Gln Ser Phe His 
    370                 375                 380                 


Val Gly Leu Gln Leu Cys Ser Ser Gly His Gln Arg Phe Asn Lys Leu 
385                 390                 395                 400 


Ile Trp Ile His His Ser Cys His Ile Thr Tyr Lys Ser Thr Gly Glu 
                405                 410                 415     


Thr Ala Val Ser Ala Phe Glu Ile Asp Lys Met Tyr Thr Pro Leu Phe 
            420                 425                 430         


Phe Ala Arg Val Arg Ser Tyr Thr Ala Phe Ser Glu Arg Pro Leu 
        435                 440                 445         


<210>  695
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  695

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  696
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Gly Phe Ser Ser Glu Leu Cys Ser Pro Gln Gly His Gly Val Leu 
1               5                   10                  15      


Gln Gln Met Gln Glu Ala Glu Leu Arg Leu Leu Glu Gly Met Arg Lys 
            20                  25                  30          


Trp Met Ala Gln Arg Val Lys Ser Asp Arg Glu Tyr Ala Gly Leu Leu 
        35                  40                  45              


His His Met Ser Leu Gln Asp Ser Gly Gly Gln Ser Arg Ala Ile Ser 
    50                  55                  60                  


Pro Asp Ser Pro Ile Ser Gln Ser Trp Ala Glu Ile Thr Ser Gln Thr 
65                  70                  75                  80  


Glu Gly Leu Ser Arg Leu Leu Arg Gln His Ala Glu Asp Leu Asn Ser 
                85                  90                  95      


Gly Pro Leu Ser Lys Leu Ser Leu Leu Ile Arg Glu Arg Gln Gln Leu 
            100                 105                 110         


Arg Lys Thr Tyr Ser Glu Gln Trp Gln Gln Leu Gln Gln Glu Leu Thr 
        115                 120                 125             


Lys Thr His Ser Gln Asp Ile Glu Lys Leu Lys Ser Gln Tyr Arg Ala 
    130                 135                 140                 


Leu Ala Arg Asp Ser Ala Gln Ala Lys Arg Lys Tyr Gln Glu Ala Ser 
145                 150                 155                 160 


Lys Asp Lys Asp Arg Asp Lys Ala Lys Asp Lys Tyr Val Arg Ser Leu 
                165                 170                 175     


Trp Lys Leu Phe Ala His His Asn Arg Tyr Val Leu Gly Val Arg Ala 
            180                 185                 190         


Ala Gln Leu His His Gln His His His Gln Leu Leu Leu Pro Gly Leu 
        195                 200                 205             


Leu Arg Ser Leu Gln Asp Leu His Glu Glu Met Ala Cys Ile Leu Lys 
    210                 215                 220                 


Glu Ile Leu Gln Glu Tyr Leu Glu Ile Ser Ser Leu Val Gln Asp Glu 
225                 230                 235                 240 


Val Val Ala Ile His Arg Glu Met Ala Ala Ala Ala Ala Arg Ile Gln 
                245                 250                 255     


Pro Glu Ala Glu Tyr Gln Gly Phe Leu Arg Gln Tyr Gly Ser Ala Pro 
            260                 265                 270         


Asp Val Pro Pro Cys Val Thr Phe Asp Glu Ser Leu Leu Glu Glu Gly 
        275                 280                 285             


Glu Pro Leu Glu Pro Gly Glu Leu Gln Leu Asn Glu Leu Thr Val Glu 
    290                 295                 300                 


Ser Val Gln His Thr Leu Thr Ser Val Thr Asp Glu Leu Ala Val Ala 
305                 310                 315                 320 


Thr Glu Met Val Phe Arg Arg Gln Glu Met Val Thr Gln Leu Gln Gln 
                325                 330                 335     


Glu Leu Arg Asn Glu Glu Glu Asn Thr His Pro Arg Glu Arg Val Gln 
            340                 345                 350         


Leu Leu Gly Lys Arg Gln Val Leu Gln Glu Ala Leu Gln Gly Leu Gln 
        355                 360                 365             


Val Ala Leu Cys Ser Gln Ala Lys Leu Gln Ala Gln Gln Glu Leu Leu 
    370                 375                 380                 


Gln Thr Lys Leu Glu His Leu Gly Pro Gly Glu Pro Pro Pro Val Leu 
385                 390                 395                 400 


Leu Leu Gln Asp Asp Arg His Ser Thr Ser Ser Ser Glu Gln Glu Arg 
                405                 410                 415     


Glu Gly Gly Arg Thr Pro Thr Leu Glu Ile Leu Lys Ser His Ile Ser 
            420                 425                 430         


Gly Ile Phe Arg Pro Lys Phe Ser Leu Pro Pro Pro Leu Gln Leu Ile 
        435                 440                 445             


Pro Glu Val Gln Lys Pro Leu His Glu Gln Leu Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ala Glu Val Ala Glu Leu Leu Val His Ser Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser Gln Gly Lys Gln Glu Tyr Val Leu Ser Val Leu 
                485                 490                 495     


Trp Asp Gly Leu Pro Arg His Phe Ile Ile Gln Ser Leu Asp Asn Leu 
            500                 505                 510         


Tyr Arg Leu Glu Gly Glu Gly Phe Pro Ser Ile Pro Leu Leu Ile Asp 
        515                 520                 525             


His Leu Leu Ser Thr Gln Gln Pro Leu Thr Lys Lys Ser Gly Val Val 
    530                 535                 540                 


Leu His Arg Ala Val Pro Lys Asp Lys Trp Val Leu Asn His Glu Asp 
545                 550                 555                 560 


Leu Val Leu Gly Glu Gln Ile Gly Arg Gly Asn Phe Gly Glu Val Phe 
                565                 570                 575     


Ser Gly Arg Leu Arg Ala Asp Asn Thr Leu Val Ala Val Lys Ser Cys 
            580                 585                 590         


Arg Glu Thr Leu Pro Pro Asp Leu Lys Ala Lys Phe Leu Gln Glu Ala 
        595                 600                 605             


Arg Ile Leu Lys Gln Tyr Ser His Pro Asn Ile Val Arg Leu Ile Gly 
    610                 615                 620                 


Val Cys Thr Gln Lys Gln Pro Ile Tyr Ile Val Met Glu Leu Val Gln 
625                 630                 635                 640 


Gly Gly Asp Phe Leu Thr Phe Leu Arg Thr Glu Gly Ala Arg Leu Arg 
                645                 650                 655     


Val Lys Thr Leu Leu Gln Met Val Gly Asp Ala Ala Ala Gly Met Glu 
            660                 665                 670         


Tyr Leu Glu Ser Lys Cys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
        675                 680                 685             


Cys Leu Val Thr Glu Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met 
    690                 695                 700                 


Ser Arg Glu Glu Ala Asp Gly Val Tyr Ala Ala Ser Gly Gly Leu Arg 
705                 710                 715                 720 


Gln Val Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Ala Ser Pro Tyr Pro Asn Leu Ser Asn Gln Gln 
        755                 760                 765             


Thr Arg Glu Phe Val Glu Lys Gly Gly Arg Leu Pro Cys Pro Glu Leu 
    770                 775                 780                 


Cys Pro Asp Ala Val Phe Arg Leu Met Glu Gln Cys Trp Ala Tyr Glu 
785                 790                 795                 800 


Pro Gly Gln Arg Pro Ser Phe Ser Thr Ile Tyr Gln Glu Leu Gln Ser 
                805                 810                 815     


Ile Arg Lys Arg His Arg 
            820         


<210>  697
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  697

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210>  698
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Gly Asn Cys His Thr Val Gly Pro Asn Glu Ala Leu Val Val Ser 
1               5                   10                  15      


Gly Gly Cys Cys Gly Ser Asp Tyr Lys Gln Tyr Val Phe Gly Gly Trp 
            20                  25                  30          


Ala Trp Ala Trp Trp Cys Ile Ser Asp Thr Gln Arg Ile Ser Leu Glu 
        35                  40                  45              


Ile Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly 
    50                  55                  60                  


Val Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu 
65                  70                  75                  80  


Lys Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val 
                85                  90                  95      


Gln Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg 
            100                 105                 110         


Ser Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp 
        115                 120                 125             


Gln Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg 
    130                 135                 140                 


Met Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys 
145                 150                 155                 160 


Val Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln 
                165                 170                 175     


Arg Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile 
            180                 185                 190         


Arg Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala 
        195                 200                 205             


Asp Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser 
    210                 215                 220                 


Ala Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala 
225                 230                 235                 240 


Tyr Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu 
                245                 250                 255     


Ile Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala 
            260                 265                 270         


Gln Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg 
        275                 280                 285             


Pro Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu 
    290                 295                 300                 


Lys Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg 
305                 310                 315                 320 


Lys Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala 
                325                 330                 335     


Glu Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly 
            340                 345                 350         


Asp Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala 
        355                 360                 365             


Ala Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu 
    370                 375                 380                 


Ser Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys 
                405                 410                 415     


Ile Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
            420                 425             


<210>  699
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  699

Met Ser Trp Gly Thr Glu Leu Trp Asp Gln Phe Asp Asn Leu Glu Lys 
1               5                   10                  15      


His Thr Gln Trp Gly Ile Asp Ile Leu Glu Lys Tyr Ile Lys Phe Val 
            20                  25                  30          


Lys Glu Arg Thr Glu Ile Glu Leu Ser Tyr Ala Lys Gln Leu Arg Asn 
        35                  40                  45              


Leu Ser Lys Lys Tyr Gln Pro Lys Lys Asn Ser Lys Glu Glu Glu Glu 
    50                  55                  60                  


Tyr Lys Tyr Thr Ser Cys Lys Ala Phe Ile Ser Asn Leu Asn Glu Met 
65                  70                  75                  80  


Asn Asp Tyr Ala Gly Gln His Glu Val Ile Ser Glu Asn Met Ala Ser 
                85                  90                  95      


Gln Ile Ile Val Asp Leu Ala Arg Tyr Val Gln Glu Leu Lys Gln Glu 
            100                 105                 110         


Arg Lys Ser Asn Phe His Asp Gly Arg Lys Ala Gln Gln His Ile Glu 
        115                 120                 125             


Thr Cys Trp Lys Gln Leu Glu Ser Ser Lys Arg Arg Phe Glu Arg Asp 
    130                 135                 140                 


Cys Lys Glu Ala Asp Arg Ala Gln Gln Tyr Phe Glu Lys Met Asp Ala 
145                 150                 155                 160 


Asp Ile Asn Val Thr Lys Ala Asp Val Glu Lys Ala Arg Gln Gln Ala 
                165                 170                 175     


Gln Ile Arg His Gln Met Ala Glu Asp Ser Lys Ala Asp Tyr Ser Ser 
            180                 185                 190         


Ile Leu Gln Lys Phe Asn His Glu Gln His Glu Tyr Tyr His Thr His 
        195                 200                 205             


Ile Pro Asn Ile Phe Gln Lys Ile Gln Glu Met Glu Glu Arg Arg Ile 
    210                 215                 220                 


Val Arg Met Gly Glu Ser Met Lys Thr Tyr Ala Glu Val Asp Arg Gln 
225                 230                 235                 240 


Val Ile Pro Ile Ile Gly Lys Cys Leu Asp Gly Ile Val Lys Ala Ala 
                245                 250                 255     


Glu Ser Ile Asp Gln Lys Asn Asp Ser Gln Leu Val Ile Glu Ala Tyr 
            260                 265                 270         


Lys Ser Gly Phe Glu Pro Pro Gly Asp Ile Glu Phe Glu Asp Tyr Thr 
        275                 280                 285             


Gln Pro Met Lys Arg Thr Val Ser Asp Asn Ser Leu Ser Asn Ser Arg 
    290                 295                 300                 


Gly Glu Gly Lys Pro Asp Leu Lys Phe Gly Gly Lys Ser Lys Gly Lys 
305                 310                 315                 320 


Leu Trp Pro Phe Ile Lys Lys Asn Lys Leu Met Ser Leu Leu Thr Ser 
                325                 330                 335     


Pro His Gln Pro Pro Pro Pro Pro Pro Ala Ser Ala Ser Pro Ser Ala 
            340                 345                 350         


Val Pro Asn Gly Pro Gln Ser Pro Lys Gln Gln Lys Glu Pro Leu Ser 
        355                 360                 365             


His Arg Phe Asn Glu Phe Met Thr Ser Lys Pro Lys Ile His Cys Phe 
    370                 375                 380                 


Arg Ser Leu Lys Arg Gly Leu Ser Leu Lys Leu Gly Ala Thr Pro Glu 
385                 390                 395                 400 


Asp Phe Ser Asn Leu Pro Pro Glu Gln Arg Arg Lys Lys Leu Gln Gln 
                405                 410                 415     


Lys Val Asp Glu Leu Asn Lys Glu Ile Gln Lys Glu Met Asp Gln Arg 
            420                 425                 430         


Asp Ala Ile Thr Lys Met Lys Asp Val Tyr Leu Lys Asn Pro Gln Met 
        435                 440                 445             


Gly Asp Pro Ala Ser Leu Asp His Lys Leu Ala Glu Val Ser Gln Asn 
    450                 455                 460                 


Ile Glu Lys Leu Arg Val Glu Thr Gln Lys Phe Glu Ala Trp Leu Ala 
465                 470                 475                 480 


Glu Val Glu Gly Arg Leu Pro Ala Arg Ser Glu Gln Ala Arg Arg Gln 
                485                 490                 495     


Ser Gly Leu Tyr Asp Ser Gln Asn Pro Pro Thr Val Asn Asn Cys Ala 
            500                 505                 510         


Gln Asp Arg Glu Ser Pro Asp Gly Ser Tyr Thr Glu Glu Gln Ser Gln 
        515                 520                 525             


Glu Ser Glu Met Lys Val Leu Ala Thr Asp Phe Asp Asp Glu Phe Asp 
    530                 535                 540                 


Asp Glu Glu Pro Leu Pro Ala Ile Gly Thr Cys Lys Ala Leu Tyr Thr 
545                 550                 555                 560 


Phe Glu Gly Gln Asn Glu Gly Thr Ile Ser Val Val Glu Gly Glu Thr 
                565                 570                 575     


Leu Tyr Val Ile Glu Glu Asp Lys Gly Asp Gly Trp Thr Arg Ile Arg 
            580                 585                 590         


Arg Asn Glu Asp Glu Glu Gly Tyr Val Pro Thr Ser Tyr Val Glu Val 
        595                 600                 605             


Cys Leu Asp Lys Asn Ala Lys Asp Ser 
    610                 615         


<210>  700
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Ala Ser Asp Leu Glu Ser Ser Leu Thr Ser Ile Asp Trp Leu Pro 
1               5                   10                  15      


Gln Leu Thr Leu Arg Ala Thr Ile Glu Lys Leu Gly Ser Ala Ser Gln 
            20                  25                  30          


Ala Gly Pro Pro Gly Ser Ser Arg Lys Cys Ser Pro Gly Ser Pro Thr 
        35                  40                  45              


Asp Pro Asn Ala Thr Leu Ser Lys Asp Glu Ala Ala Val His Gln Asp 
    50                  55                  60                  


Gly Lys Pro Arg Tyr Ser Tyr Ala Thr Leu Ile Thr Tyr Ala Ile Asn 
65                  70                  75                  80  


Ser Ser Pro Ala Lys Lys Met Thr Leu Ser Glu Ile Tyr Arg Trp Ile 
                85                  90                  95      


Cys Asp Asn Phe Pro Tyr Tyr Lys Asn Ala Gly Ile Gly Trp Lys Asn 
            100                 105                 110         


Ser Ile Arg His Asn Leu Ser Leu Asn Lys Cys Phe Arg Lys Val Pro 
        115                 120                 125             


Arg Pro Arg Asp Asp Pro Gly Lys Gly Ser Tyr Trp Thr Ile Asp Thr 
    130                 135                 140                 


Cys Pro Asp Ile Ser Arg Lys Arg Arg His Pro Pro Asp Asp Asp Leu 
145                 150                 155                 160 


Ser Gln Asp Ser Pro Glu Gln Glu Ala Ser Lys Ser Pro Arg Gly Gly 
                165                 170                 175     


Val Ala Gly Ser Gly Glu Ala Ser Leu Pro Pro Glu Gly Asn Pro Gln 
            180                 185                 190         


Met Ser Leu Gln Ser Pro Thr Ser Ile Ala Ser Tyr Ser Gln Gly Thr 
        195                 200                 205             


Gly Ser Val Asp Gly Gly Ala Val Ala Ala Gly Ala Ser Gly Arg Glu 
    210                 215                 220                 


Ser Ala Glu Gly Pro Pro Pro Leu Tyr Asn Thr Asn His Asp Phe Lys 
225                 230                 235                 240 


Phe Ser Tyr Ser Glu Ile Asn Phe Gln Asp Leu Ser Trp Ser Phe Arg 
                245                 250                 255     


Asn Leu Tyr Lys Ser Met Leu Glu Lys Ser Ser Ser Ser Ser Gln His 
            260                 265                 270         


Gly Phe Ser Ser Leu Leu Gly Asp Ile Pro Pro Ser Asn Asn Tyr Tyr 
        275                 280                 285             


Met Tyr Gln Gln Gln Gln Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Pro Pro Gln Pro Pro Pro Gln Gln Ser Gln Pro Gln Gln Gln 
305                 310                 315                 320 


Gln Ala Pro Ala Gln Gly Pro Ser Ala Val Gly Gly Ala Pro Pro Leu 
                325                 330                 335     


His Thr Pro Ser Thr Asp Gly Cys Thr Pro Pro Gly Gly Lys Gln Ala 
            340                 345                 350         


Gly Ala Glu Gly Tyr Gly Pro Pro Pro Val Met Ala Met His Pro Pro 
        355                 360                 365             


Pro Leu Gln His Gly Gly Tyr His Pro His Gln His His Pro His Ser 
    370                 375                 380                 


His Pro Ala Gln Gln Pro Pro Pro Pro Gln Pro Gln Ala Gln Gly Gln 
385                 390                 395                 400 


Ala Pro Ile Asn Asn Thr Gly Phe Ala Phe Pro Ser Asp Trp Cys Ser 
                405                 410                 415     


Asn Ile Asp Ser Leu Lys Glu Ser Phe Lys Met Val Asn Arg Leu Asn 
            420                 425                 430         


Trp Ser Ser Ile Glu Gln Ser Gln Phe Ser Glu Leu Met Glu Ser Leu 
        435                 440                 445             


Arg Gln Ala Glu Gln Lys Asn Trp Thr Leu Asp Gln His His Ile Ala 
    450                 455                 460                 


Asn Leu Cys Asp Ser Leu Asn His Phe Leu Thr Gln Thr Gly His Val 
465                 470                 475                 480 


Pro Pro Gln Gly Gly Thr His Arg Pro Pro Ala Pro Ala Arg Ile Ala 
                485                 490                 495     


Asp Ser Cys Ala Leu Thr Ser Gly Lys Gln Glu Ser Ala Met Ser Gln 
            500                 505                 510         


Val Asn Ser Tyr Gly His Pro Gln Ala Pro His Leu Tyr Pro Gly Pro 
        515                 520                 525             


Ser Pro Met Tyr Pro Ile Pro Thr Gln Asp Ser Ala Gly Tyr Asn Arg 
    530                 535                 540                 


Pro Ala His His Met Val Pro Arg Pro Ser Val Pro Pro Pro Gly Ala 
545                 550                 555                 560 


Asn Glu Glu Ile Pro Asp Asp Phe Asp Trp Asp Leu Ile Thr 
                565                 570                 


<210>  701
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  701

Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala 
    50                  55                  60                  


Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly 
            100                 105                 110         


Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro 
        115                 120                 125             


Gly Pro Leu Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro 
    130                 135                 140                 


Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp 
145                 150                 155                 160 


Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser 
                165                 170                 175     


Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys 
            180                 185                 190         


Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly 
        195                 200                 205             


Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile 
    210                 215                 220                 


Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn 
225                 230                 235                 240 


Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser 
                245                 250                 255     


Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys 
            260                 265                 270         


Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro 
        275                 280                 285             


Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn 
    290                 295                 300                 


Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn 
305                 310                 315                 320 


Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp 
                325                 330                 335     


Asp Leu Gly Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala 
            340                 345                 350         


Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro 
        355                 360                 365             


Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro 
    370                 375                 380                 


Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln 
385                 390                 395                 400 


Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser 
                405                 410                 415     


Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser 
            420                 425                 430         


Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser 
        435                 440                 445             


Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu 
    450                 455                 460                 


Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val 
465                 470                 475                 480 


Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val 
                485                 490                 495     


Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser 
            500                 505                 510         


His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala 
        515                 520                 525             


Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser 
    530                 535                 540                 


Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr 
545                 550                 555                 560 


Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly 
                565                 570                 575     


Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu 
            580                 585                 590         


Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu 
        595                 600                 605             


Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp 
    610                 615                 620                 


Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser 
625                 630                 635                 640 


Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650                 655 


<210>  702
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Ala Glu Ala Pro Ala Ser Pro Ala Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Gly Ser Ala Met Ala Ile Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp 
                85                  90                  95      


Ser Ala Arg Val Leu Ala Pro Gly Gly Gln Asp Pro Gly Ser Gly Pro 
            100                 105                 110         


Ala Thr Ala Ala Gly Gly Leu Ser Gly Gly Thr Gln Ala Leu Leu Gln 
        115                 120                 125             


Pro Gln Gln Pro Leu Pro Pro Pro Gln Pro Gly Ala Ala Gly Gly Ser 
    130                 135                 140                 


Gly Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn 
                245                 250                 255     


Ser Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ala Leu Gln Thr Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu 
        275                 280                 285             


Ser Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp 
    290                 295                 300                 


Ala Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val 
305                 310                 315                 320 


Ser Gly Arg Leu Ser Pro Ile Met Ala Ser Thr Glu Leu Asp Glu Val 
                325                 330                 335     


Gln Asp Asp Asp Ala Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala 
            340                 345                 350         


Ser Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg 
        355                 360                 365             


Leu Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Thr Glu 
    370                 375                 380                 


Asn Leu Met Asp Asp Leu Leu Asp Asn Ile Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Thr Gly Gly Leu Met Gln Arg Ser Ser Ser Phe Pro Tyr 
                405                 410                 415     


Thr Thr Lys Gly Ser Gly Leu Gly Ser Pro Thr Ser Ser Phe Asn Ser 
            420                 425                 430         


Thr Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met 
        435                 440                 445             


Gln Thr Ile Gln Glu Asn Lys Pro Ala Thr Phe Ser Ser Met Ser His 
    450                 455                 460                 


Tyr Gly Asn Gln Thr Leu Gln Asp Leu Leu Thr Ser Asp Ser Leu Ser 
465                 470                 475                 480 


His Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala 
                485                 490                 495     


Ser Thr Ala Val Ser Ala Gln Asn Ser Arg Arg Asn Val Met Leu Arg 
            500                 505                 510         


Asn Asp Pro Met Met Ser Phe Ala Ala Gln Pro Asn Gln Gly Ser Leu 
        515                 520                 525             


Val Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu 
    530                 535                 540                 


Gly Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser 
545                 550                 555                 560 


Glu Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Val 
                565                 570                 575     


Ser Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu 
            580                 585                 590         


Tyr Ser Thr Ser Ala Asn Leu Pro Val Met Gly His Glu Lys Phe Pro 
        595                 600                 605             


Ser Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met 
    610                 615                 620                 


Glu Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe 
625                 630                 635                 640 


Asn Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val 
                645                 650                 655     


Gly Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro 
            660                 665                 670         


Gly 
    


<210>  703
<211>  3013
<212>  PRT
<213>  Homo sapiens

<400>  703

Met Ala Ser Gln Gln Asp Ser Gly Phe Phe Glu Ile Ser Ile Lys Tyr 
1               5                   10                  15      


Leu Leu Lys Ser Trp Ser Asn Thr Ser Pro Val Gly Asn Gly Tyr Ile 
            20                  25                  30          


Lys Pro Pro Val Pro Pro Ala Ser Gly Thr His Arg Glu Lys Gly Pro 
        35                  40                  45              


Pro Thr Met Leu Pro Ile Asn Val Asp Pro Asp Ser Lys Pro Gly Glu 
    50                  55                  60                  


Tyr Val Leu Lys Ser Leu Phe Val Asn Phe Thr Thr Gln Ala Glu Arg 
65                  70                  75                  80  


Lys Ile Arg Ile Ile Met Ala Glu Pro Leu Glu Lys Pro Leu Thr Lys 
                85                  90                  95      


Ser Leu Gln Arg Gly Glu Asp Pro Gln Phe Asp Gln Val Ile Ser Ser 
            100                 105                 110         


Met Ser Ser Leu Ser Glu Tyr Cys Leu Pro Ser Ile Leu Arg Thr Leu 
        115                 120                 125             


Phe Asp Trp Tyr Lys Arg Gln Asn Gly Ile Glu Asp Glu Ser His Glu 
    130                 135                 140                 


Tyr Arg Pro Arg Thr Ser Asn Lys Ser Lys Ser Asp Glu Gln Gln Arg 
145                 150                 155                 160 


Asp Tyr Leu Met Glu Arg Arg Asp Leu Ala Ile Asp Phe Ile Phe Ser 
                165                 170                 175     


Leu Val Leu Ile Glu Val Leu Lys Gln Ile Pro Leu His Pro Val Ile 
            180                 185                 190         


Asp Ser Leu Ile His Asp Val Ile Asn Leu Ala Phe Lys His Phe Lys 
        195                 200                 205             


Tyr Lys Glu Gly Tyr Leu Gly Pro Asn Thr Gly Asn Met His Ile Val 
    210                 215                 220                 


Ala Asp Leu Tyr Ala Glu Val Ile Gly Val Leu Ala Gln Ala Lys Phe 
225                 230                 235                 240 


Pro Ala Val Lys Lys Lys Phe Met Ala Glu Leu Lys Glu Leu Arg His 
                245                 250                 255     


Lys Glu Gln Asn Pro Tyr Val Val Gln Ser Ile Ile Ser Leu Ile Met 
            260                 265                 270         


Gly Met Lys Phe Phe Arg Ile Lys Met Tyr Pro Val Glu Asp Phe Glu 
        275                 280                 285             


Ala Ser Leu Gln Phe Met Gln Glu Cys Ala His Tyr Phe Leu Glu Val 
    290                 295                 300                 


Lys Asp Lys Asp Ile Lys His Ala Leu Ala Gly Leu Phe Val Glu Ile 
305                 310                 315                 320 


Leu Val Pro Val Ala Ala Ala Val Lys Asn Glu Val Asn Val Pro Cys 
                325                 330                 335     


Leu Arg Asn Phe Val Glu Ser Leu Tyr Asp Thr Thr Leu Glu Leu Ser 
            340                 345                 350         


Ser Arg Lys Lys His Ser Leu Ala Leu Tyr Pro Leu Val Thr Cys Leu 
        355                 360                 365             


Leu Cys Val Ser Gln Lys Gln Leu Phe Leu Asn Arg Trp His Ile Phe 
    370                 375                 380                 


Leu Asn Asn Cys Leu Ser Asn Leu Lys Asn Lys Asp Pro Lys Met Ala 
385                 390                 395                 400 


Arg Val Ala Leu Glu Ser Leu Tyr Arg Leu Leu Trp Val Tyr Met Ile 
                405                 410                 415     


Arg Ile Lys Cys Glu Ser Asn Thr Ala Thr Gln Ser Arg Leu Ile Thr 
            420                 425                 430         


Ile Ile Thr Thr Leu Phe Pro Lys Gly Ser Arg Gly Val Val Pro Arg 
        435                 440                 445             


Asp Met Pro Leu Asn Ile Phe Val Lys Ile Ile Gln Phe Ile Ala Gln 
    450                 455                 460                 


Glu Arg Leu Asp Phe Ala Met Lys Glu Ile Ile Phe Asp Phe Leu Cys 
465                 470                 475                 480 


Val Gly Lys Pro Ala Lys Ala Phe Ser Leu Asn Pro Glu Arg Met Asn 
                485                 490                 495     


Ile Gly Leu Arg Ala Phe Leu Val Ile Ala Asp Ser Leu Gln Gln Lys 
            500                 505                 510         


Asp Gly Glu Pro Pro Met Pro Val Thr Gly Ala Val Leu Pro Ser Gly 
        515                 520                 525             


Asn Thr Leu Arg Val Lys Lys Thr Tyr Leu Ser Lys Thr Leu Thr Glu 
    530                 535                 540                 


Glu Glu Ala Lys Met Ile Gly Met Ser Leu Tyr Tyr Ser Gln Val Arg 
545                 550                 555                 560 


Lys Ala Val Asp Asn Ile Leu Arg His Leu Asp Lys Glu Val Gly Arg 
                565                 570                 575     


Cys Met Met Leu Thr Asn Val Gln Met Leu Asn Lys Glu Pro Glu Asp 
            580                 585                 590         


Met Ile Thr Gly Glu Arg Lys Pro Lys Ile Asp Leu Phe Arg Thr Cys 
        595                 600                 605             


Val Ala Ala Ile Pro Arg Leu Leu Pro Asp Gly Met Ser Lys Leu Glu 
    610                 615                 620                 


Leu Ile Asp Leu Leu Ala Arg Leu Ser Ile His Met Asp Asp Glu Leu 
625                 630                 635                 640 


Arg His Ile Ala Gln Asn Ser Leu Gln Gly Leu Leu Val Asp Phe Ser 
                645                 650                 655     


Asp Trp Arg Glu Asp Val Leu Phe Gly Phe Thr Asn Phe Leu Leu Arg 
            660                 665                 670         


Glu Val Asn Asp Met His His Thr Leu Leu Asp Ser Ser Leu Lys Leu 
        675                 680                 685             


Leu Leu Gln Leu Leu Thr Gln Trp Lys Leu Val Ile Gln Thr Gln Gly 
    690                 695                 700                 


Lys Val Tyr Glu Gln Ala Asn Lys Ile Arg Asn Ser Glu Leu Ile Ala 
705                 710                 715                 720 


Asn Gly Ser Ser His Arg Ile Gln Ser Glu Arg Gly Pro His Cys Ser 
                725                 730                 735     


Val Leu His Ala Val Glu Gly Phe Ala Leu Val Leu Leu Cys Ser Phe 
            740                 745                 750         


Gln Val Ala Thr Arg Lys Leu Ser Val Leu Ile Leu Lys Glu Ile Arg 
        755                 760                 765             


Ala Leu Phe Ile Ala Leu Gly Gln Pro Glu Asp Asp Asp Arg Pro Met 
    770                 775                 780                 


Ile Asp Val Met Asp Gln Leu Ser Ser Ser Ile Leu Glu Ser Phe Ile 
785                 790                 795                 800 


His Val Ala Val Ser Asp Ser Ala Thr Leu Pro Leu Thr His Asn Val 
                805                 810                 815     


Asp Leu Gln Trp Leu Val Glu Trp Asn Ala Val Leu Val Asn Ser His 
            820                 825                 830         


Tyr Asp Val Lys Ser Pro Ser His Val Trp Ile Phe Ala Gln Ser Val 
        835                 840                 845             


Lys Asp Pro Trp Val Leu Cys Leu Phe Ser Phe Leu Arg Gln Glu Asn 
    850                 855                 860                 


Leu Pro Lys His Cys Pro Thr Ala Leu Ser Tyr Ala Trp Pro Tyr Ala 
865                 870                 875                 880 


Phe Thr Arg Leu Gln Ser Val Met Pro Leu Val Asp Pro Asn Ser Pro 
                885                 890                 895     


Ile Asn Ala Lys Lys Thr Ser Thr Ala Gly Ser Gly Asp Asn Tyr Val 
            900                 905                 910         


Thr Leu Trp Arg Asn Tyr Leu Ile Leu Cys Phe Gly Val Ala Lys Pro 
        915                 920                 925             


Ser Ile Met Ser Pro Gly His Leu Arg Ala Ser Thr Pro Glu Ile Met 
    930                 935                 940                 


Ala Thr Thr Pro Asp Gly Thr Val Ser Tyr Asp Asn Lys Ala Ile Gly 
945                 950                 955                 960 


Thr Pro Ser Val Gly Val Leu Leu Lys Gln Leu Val Pro Leu Met Arg 
                965                 970                 975     


Leu Glu Ser Ile Glu Ile Thr Glu Ser Leu Val Leu Gly Phe Gly Arg 
            980                 985                 990         


Thr Asn Ser Leu Val Phe Arg Glu  Leu Val Glu Glu Leu  His Pro Leu 
        995                 1000                 1005             


Met Lys  Glu Ala Leu Glu Arg  Arg Pro Glu Asn Lys  Lys Arg Arg 
    1010                 1015                 1020             


Glu Arg  Arg Asp Leu Leu Arg  Leu Gln Leu Leu Arg  Ile Phe Glu 
    1025                 1030                 1035             


Leu Leu  Ala Asp Ala Gly Val  Ile Ser Asp Ser Thr  Asn Gly Ala 
    1040                 1045                 1050             


Leu Glu  Arg Asp Thr Leu Ala  Leu Gly Ala Leu Phe  Leu Glu Tyr 
    1055                 1060                 1065             


Val Asp  Leu Thr Arg Met Leu  Leu Glu Ala Glu Asn  Asp Lys Glu 
    1070                 1075                 1080             


Val Glu  Ile Leu Lys Asp Ile  Arg Ala His Phe Ser  Ala Met Val 
    1085                 1090                 1095             


Ala Asn  Leu Ile Gln Cys Val  Pro Val His His Arg  Arg Phe Leu 
    1100                 1105                 1110             


Phe Pro  Gln Gln Ser Leu Arg  His His Leu Phe Ile  Leu Phe Ser 
    1115                 1120                 1125             


Gln Trp  Ala Gly Pro Phe Ser  Ile Met Phe Thr Pro  Leu Asp Arg 
    1130                 1135                 1140             


Tyr Ser  Asp Arg Asn His Gln  Ile Thr Arg Tyr Gln  Tyr Cys Ala 
    1145                 1150                 1155             


Leu Lys  Ala Met Ser Ala Val  Leu Cys Cys Gly Pro  Val Phe Asp 
    1160                 1165                 1170             


Asn Val  Gly Leu Ser Pro Asp  Gly Tyr Leu Tyr Lys  Trp Leu Asp 
    1175                 1180                 1185             


Asn Ile  Leu Ala Cys Gln Asp  Leu Arg Val His Gln  Leu Gly Cys 
    1190                 1195                 1200             


Glu Val  Val Val Leu Leu Leu  Glu Leu Asn Pro Asp  Gln Ile Asn 
    1205                 1210                 1215             


Leu Phe  Asn Trp Ala Ile Asp  Arg Cys Tyr Thr Gly  Ser Tyr Gln 
    1220                 1225                 1230             


Leu Ala  Ser Gly Cys Phe Lys  Ala Ile Ala Thr Val  Cys Gly Ser 
    1235                 1240                 1245             


Arg Asn  Tyr Pro Phe Asp Ile  Val Thr Leu Leu Asn  Leu Val Leu 
    1250                 1255                 1260             


Phe Lys  Ala Ser Asp Thr Asn  Arg Glu Ile Tyr Glu  Ile Ser Met 
    1265                 1270                 1275             


Gln Leu  Met Gln Ile Leu Glu  Ala Lys Leu Phe Val  Tyr Ser Lys 
    1280                 1285                 1290             


Lys Val  Ala Glu Gln Arg Pro  Gly Ser Ile Leu Tyr  Gly Thr His 
    1295                 1300                 1305             


Gly Pro  Leu Pro Pro Leu Tyr  Ser Val Ser Leu Ala  Leu Leu Ser 
    1310                 1315                 1320             


Cys Glu  Leu Ala Arg Met Tyr  Pro Glu Leu Thr Leu  Pro Leu Phe 
    1325                 1330                 1335             


Ser Glu  Val Ser Gln Arg Phe  Pro Thr Thr His Pro  Asn Gly Arg 
    1340                 1345                 1350             


Gln Ile  Met Leu Thr Tyr Leu  Leu Pro Trp Leu His  Asn Ile Glu 
    1355                 1360                 1365             


Leu Val  Asp Ser Arg Leu Leu  Leu Pro Gly Ser Ser  Pro Ser Ser 
    1370                 1375                 1380             


Pro Glu  Asp Glu Val Lys Asp  Arg Glu Gly Asp Val  Thr Ala Ser 
    1385                 1390                 1395             


His Gly  Leu Arg Gly Asn Gly  Trp Gly Ser Pro Glu  Ala Thr Ser 
    1400                 1405                 1410             


Leu Val  Leu Asn Asn Leu Met  Tyr Met Thr Ala Lys  Tyr Gly Asp 
    1415                 1420                 1425             


Glu Val  Pro Gly Pro Glu Met  Glu Asn Ala Trp Asn  Ala Leu Ala 
    1430                 1435                 1440             


Asn Asn  Glu Lys Trp Ser Asn  Asn Leu Arg Ile Thr  Leu Gln Phe 
    1445                 1450                 1455             


Leu Ile  Ser Leu Cys Gly Val  Ser Ser Asp Thr Val  Leu Leu Pro 
    1460                 1465                 1470             


Tyr Ile  Lys Lys Val Ala Ile  Tyr Leu Cys Arg Asn  Asn Thr Ile 
    1475                 1480                 1485             


Gln Thr  Met Glu Glu Leu Leu  Phe Glu Leu Gln Gln  Thr Glu Pro 
    1490                 1495                 1500             


Val Asn  Pro Ile Val Gln His  Cys Asp Asn Pro Pro  Phe Tyr Arg 
    1505                 1510                 1515             


Phe Thr  Ala Ser Ser Lys Ala  Ser Ala Ala Ala Ser  Gly Thr Thr 
    1520                 1525                 1530             


Ser Ser  Ser Asn Thr Val Val  Ala Gly Gln Glu Asn  Phe Pro Asp 
    1535                 1540                 1545             


Ala Glu  Glu Asn Lys Ile Leu  Lys Glu Ser Asp Glu  Arg Phe Ser 
    1550                 1555                 1560             


Asn Val  Ile Arg Ala His Thr  Arg Leu Glu Ser Arg  Tyr Ser Asn 
    1565                 1570                 1575             


Ser Ser  Gly Gly Ser Tyr Asp  Glu Asp Lys Asn Asp  Pro Ile Ser 
    1580                 1585                 1590             


Pro Tyr  Thr Gly Trp Leu Leu  Thr Ile Thr Glu Thr  Lys Gln Pro 
    1595                 1600                 1605             


Gln Pro  Leu Pro Met Pro Cys  Thr Gly Gly Cys Trp  Ala Pro Leu 
    1610                 1615                 1620             


Val Asp  Tyr Leu Pro Glu Thr  Ile Thr Pro Arg Gly  Pro Leu His 
    1625                 1630                 1635             


Arg Cys  Asn Ile Ala Val Ile  Phe Met Thr Glu Met  Val Val Asp 
    1640                 1645                 1650             


His Ser  Val Arg Glu Asp Trp  Ala Leu His Leu Pro  Leu Leu Leu 
    1655                 1660                 1665             


His Ala  Val Phe Leu Gly Leu  Asp His Tyr Arg Pro  Glu Val Phe 
    1670                 1675                 1680             


Glu His  Ser Lys Lys Leu Leu  Leu His Leu Leu Ile  Ala Leu Ser 
    1685                 1690                 1695             


Cys Asn  Ser Asn Phe His Ser  Ile Ala Ser Val Leu  Leu Gln Thr 
    1700                 1705                 1710             


Arg Glu  Met Gly Glu Ala Lys  Thr Leu Thr Val Gln  Pro Ala Tyr 
    1715                 1720                 1725             


Gln Pro  Glu Tyr Leu Tyr Thr  Gly Gly Phe Asp Phe  Leu Arg Glu 
    1730                 1735                 1740             


Asp Gln  Ser Ser Pro Val Pro  Asp Ser Gly Leu Ser  Ser Ser Ser 
    1745                 1750                 1755             


Thr Ser  Ser Ser Ile Ser Leu  Gly Gly Ser Ser Gly  Asn Leu Pro 
    1760                 1765                 1770             


Gln Met  Thr Gln Glu Val Glu  Asp Val Asp Thr Ala  Ala Glu Thr 
    1775                 1780                 1785             


Asp Glu  Lys Ala Asn Lys Leu  Ile Glu Phe Leu Thr  Thr Arg Ala 
    1790                 1795                 1800             


Phe Gly  Pro Leu Trp Cys His  Glu Asp Ile Thr Pro  Lys Asn Gln 
    1805                 1810                 1815             


Asn Ser  Lys Ser Ala Glu Gln  Leu Thr Asn Phe Leu  Arg His Val 
    1820                 1825                 1830             


Val Ser  Val Phe Lys Asp Ser  Lys Ser Gly Phe His  Leu Glu His 
    1835                 1840                 1845             


Gln Leu  Ser Glu Val Ala Leu  Gln Thr Ala Leu Ala  Ser Ser Ser 
    1850                 1855                 1860             


Arg His  Tyr Ala Gly Arg Ser  Phe Gln Ile Phe Arg  Ala Leu Lys 
    1865                 1870                 1875             


Gln Pro  Leu Ser Ala His Ala  Leu Ser Asp Leu Leu  Ser Arg Leu 
    1880                 1885                 1890             


Val Glu  Val Ile Gly Glu His  Gly Asp Glu Ile Gln  Gly Tyr Val 
    1895                 1900                 1905             


Met Glu  Ala Leu Leu Thr Leu  Glu Ala Ala Val Asp  Asn Leu Ser 
    1910                 1915                 1920             


Asp Cys  Leu Lys Asn Ser Asp  Leu Leu Thr Val Leu  Ser Arg Ser 
    1925                 1930                 1935             


Ser Ser  Pro Asp Leu Ser Ser  Ser Ser Lys Leu Thr  Ala Ser Arg 
    1940                 1945                 1950             


Lys Ser  Thr Gly Gln Leu Asn  Met Asn Pro Gly Thr  Thr Ser Gly 
    1955                 1960                 1965             


Asn Thr  Ala Thr Ala Glu Arg  Ser Arg His Gln Arg  Ser Phe Ser 
    1970                 1975                 1980             


Val Pro  Lys Lys Phe Gly Val  Ile Asp Arg Ser Ser  Asp Pro Pro 
    1985                 1990                 1995             


Arg Ser  Ala Thr Leu Asp Arg  Ile Gln Ala Cys Thr  Gln Gln Gly 
    2000                 2005                 2010             


Leu Ser  Ser Lys Thr Arg Ser  Ser Ser Ser Leu Lys  Asp Ser Leu 
    2015                 2020                 2025             


Thr Asp  Pro Ser His Ile Asn  His Pro Thr Asn Leu  Leu Ala Thr 
    2030                 2035                 2040             


Ile Phe  Trp Val Thr Val Ala  Leu Met Glu Ser Asp  Phe Glu Phe 
    2045                 2050                 2055             


Glu Tyr  Leu Met Ala Leu Arg  Leu Leu Ser Arg Leu  Leu Ala His 
    2060                 2065                 2070             


Met Pro  Leu Asp Lys Ala Glu  Asn Arg Glu Lys Leu  Glu Lys Leu 
    2075                 2080                 2085             


Gln Ala  Gln Leu Lys Trp Ala  Asp Phe Ser Gly Leu  Gln Gln Leu 
    2090                 2095                 2100             


Leu Leu  Lys Gly Phe Thr Ser  Leu Thr Thr Thr Asp  Leu Thr Leu 
    2105                 2110                 2115             


Gln Leu  Phe Ser Leu Leu Thr  Pro Val Ser Lys Ile  Ser Met Val 
    2120                 2125                 2130             


Asp Ala  Ser His Ala Ile Gly  Phe Pro Leu Asn Val  Leu Cys Leu 
    2135                 2140                 2145             


Leu Pro  Gln Leu Ile Gln His  Phe Glu Asn Pro Asn  Gln Phe Cys 
    2150                 2155                 2160             


Lys Asp  Ile Ala Glu Arg Ile  Ala Gln Val Cys Leu  Glu Glu Lys 
    2165                 2170                 2175             


Asn Pro  Lys Leu Ser Asn Leu  Ala His Val Met Thr  Leu Tyr Lys 
    2180                 2185                 2190             


Thr His  Ser Tyr Thr Arg Asp  Cys Ala Thr Trp Val  Asn Val Val 
    2195                 2200                 2205             


Cys Arg  Tyr Leu His Glu Ala  Tyr Ala Asp Ile Thr  Leu Asn Met 
    2210                 2215                 2220             


Val Thr  Tyr Leu Ala Glu Leu  Leu Glu Lys Gly Leu  Pro Ser Val 
    2225                 2230                 2235             


Gln Gln  Pro Leu Leu Gln Val  Ile Tyr Ser Leu Leu  Ser Tyr Met 
    2240                 2245                 2250             


Asp Leu  Ser Val Val Pro Val  Lys Gln Phe Asn Val  Glu Val Leu 
    2255                 2260                 2265             


Lys Thr  Ile Glu Lys Tyr Val  Gln Ser Val His Trp  Arg Glu Ala 
    2270                 2275                 2280             


Leu Asn  Ile Leu Lys Leu Val  Val Ser Arg Ser Ala  Ser Leu Val 
    2285                 2290                 2295             


Leu Pro  Ser Tyr Gln His Ser  Asp Leu Ser Lys Ile  Glu Ile His 
    2300                 2305                 2310             


Arg Val  Trp Thr Ser Ala Ser  Lys Glu Leu Pro Gly  Lys Thr Leu 
    2315                 2320                 2325             


Asp Phe  His Phe Asp Ile Ser  Glu Thr Pro Ile Ile  Gly Arg Arg 
    2330                 2335                 2340             


Tyr Asp  Glu Leu Gln Asn Ser  Ser Gly Arg Asp Gly  Lys Pro Arg 
    2345                 2350                 2355             


Ala Met  Ala Val Thr Arg Ser  Thr Ser Ser Thr Ser  Ser Gly Ser 
    2360                 2365                 2370             


Asn Ser  Asn Val Leu Val Pro  Val Ser Trp Lys Arg  Pro Gln Tyr 
    2375                 2380                 2385             


Ser Gln  Lys Arg Thr Lys Glu  Lys Leu Val His Val  Leu Ser Leu 
    2390                 2395                 2400             


Cys Gly  Gln Glu Val Gly Leu  Ser Lys Asn Pro Ser  Val Ile Phe 
    2405                 2410                 2415             


Ser Ser  Cys Gly Asp Leu Asp  Leu Leu Glu His Gln  Thr Ser Leu 
    2420                 2425                 2430             


Val Ser  Ser Glu Asp Gly Ala  Arg Glu Gln Glu Asn  Met Asp Asp 
    2435                 2440                 2445             


Thr Asn  Ser Glu Gln Gln Phe  Arg Val Phe Arg Asp  Phe Asp Phe 
    2450                 2455                 2460             


Leu Asp  Val Glu Leu Glu Asp  Gly Glu Gly Glu Ser  Met Asp Asn 
    2465                 2470                 2475             


Phe Asn  Trp Gly Val Arg Arg  Arg Ser Leu Asp Ser  Leu Asp Lys 
    2480                 2485                 2490             


Cys Asp  Met Gln Ile Leu Glu  Glu Arg Gln Leu Ser  Gly Ser Thr 
    2495                 2500                 2505             


Pro Ser  Leu Asn Lys Met His  His Glu Asp Ser Asp  Glu Ser Ser 
    2510                 2515                 2520             


Glu Glu  Glu Asp Leu Thr Ala  Ser Gln Ile Leu Glu  His Ser Asp 
    2525                 2530                 2535             


Leu Ile  Met Thr Leu Ser Pro  Ser Glu Glu Thr Asn  Pro Met Glu 
    2540                 2545                 2550             


Leu Leu  Thr Thr Ala Cys Asp  Ser Thr Pro Ala Glu  Pro His Ser 
    2555                 2560                 2565             


Phe Asn  Thr Arg Met Ser Ser  Phe Asp Ala Ser Leu  Pro Asp Met 
    2570                 2575                 2580             


Asn Asn  Leu Gln Ile Ser Glu  Gly Ser Lys Ala Glu  Ala Val Arg 
    2585                 2590                 2595             


Glu Glu  Glu Asp Thr Thr Val  His Glu Asp Asp Leu  Ser Ser Ser 
    2600                 2605                 2610             


Ile Asn  Glu Leu Pro Ala Ala  Phe Glu Cys Ser Asp  Ser Phe Ser 
    2615                 2620                 2625             


Leu Asp  Met Thr Glu Gly Glu  Glu Lys Gly Asn Arg  Ala Leu Asp 
    2630                 2635                 2640             


Gln Phe  Thr Leu Ala Ser Phe  Gly Glu Gly Asp Arg  Gly Val Ser 
    2645                 2650                 2655             


Pro Pro  Pro Ser Pro Phe Phe  Ser Ala Ile Leu Ala  Ala Phe Gln 
    2660                 2665                 2670             


Pro Ala  Ala Cys Asp Asp Ala  Glu Glu Ala Trp Arg  Ser His Ile 
    2675                 2680                 2685             


Asn Gln  Leu Met Cys Asp Ser  Asp Gly Ser Cys Ala  Val Tyr Thr 
    2690                 2695                 2700             


Phe His  Val Phe Ser Ser Leu  Phe Lys Asn Ile Gln  Lys Arg Phe 
    2705                 2710                 2715             


Cys Phe  Leu Thr Cys Asp Ala  Ala Ser Tyr Leu Gly  Asp Asn Leu 
    2720                 2725                 2730             


Arg Gly  Ile Gly Ser Lys Phe  Val Ser Ser Ser Gln  Met Leu Thr 
    2735                 2740                 2745             


Ser Cys  Ser Glu Cys Pro Thr  Leu Phe Val Asp Ala  Glu Thr Leu 
    2750                 2755                 2760             


Leu Ser  Cys Gly Leu Leu Asp  Lys Leu Lys Phe Ser  Val Leu Glu 
    2765                 2770                 2775             


Leu Gln  Glu Tyr Leu Asp Thr  Tyr Asn Asn Arg Lys  Glu Ala Thr 
    2780                 2785                 2790             


Leu Ser  Trp Leu Ala Asn Cys  Lys Ala Thr Phe Ala  Gly Gly Ser 
    2795                 2800                 2805             


Arg Asp  Gly Val Ile Thr Cys  Gln Pro Gly Asp Ser  Glu Glu Lys 
    2810                 2815                 2820             


Gln Leu  Glu Leu Cys Gln Arg  Leu Tyr Lys Leu His  Phe Gln Leu 
    2825                 2830                 2835             


Leu Leu  Leu Phe Gln Ser Tyr  Cys Lys Leu Ile Gly  Gln Val His 
    2840                 2845                 2850             


Glu Val  Ser Ser Met Pro Glu  Leu Leu Asn Met Ser  Arg Glu Leu 
    2855                 2860                 2865             


Ser Asp  Leu Lys Lys His Leu  Lys Glu Ala Ser Ala  Val Ile Ala 
    2870                 2875                 2880             


Ala Asp  Pro Leu Tyr Ser Asp  Gly Ala Trp Ser Glu  Pro Thr Phe 
    2885                 2890                 2895             


Thr Ser  Thr Glu Ala Ala Ile  Gln Ser Met Leu Glu  Cys Leu Lys 
    2900                 2905                 2910             


Asn Asn  Glu Leu Gly Lys Ala  Leu Arg Gln Ile Arg  Glu Cys Arg 
    2915                 2920                 2925             


Ser Leu  Trp Pro Asn Asp Ile  Phe Gly Ser Ser Ser  Asp Asp Glu 
    2930                 2935                 2940             


Val Gln  Thr Leu Leu Asn Ile  Tyr Phe Arg His Gln  Thr Leu Gly 
    2945                 2950                 2955             


Gln Thr  Gly Thr Tyr Ala Leu  Val Gly Ser Asn Gln  Ser Leu Thr 
    2960                 2965                 2970             


Glu Ile  Cys Thr Lys Leu Met  Glu Leu Asn Met Glu  Ile Arg Asp 
    2975                 2980                 2985             


Met Ile  Arg Arg Ala Gln Ser  Tyr Arg Val Leu Thr  Thr Phe Leu 
    2990                 2995                 3000             


Pro Asp  Ser Ser Val Ser Gly  Thr Ser Leu 
    3005                 3010             


<210>  704
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln 
625                 630                 635                 640 


Val Gln Glu Lys Ser Asn Thr Trp Ser Trp Gly Ile Leu Lys Met Leu 
                645                 650                 655     


Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile Arg Glu Lys Pro Lys Val 
            660                 665                 670         


Ser Asp Ser Asp Asn Asn Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys 
        675                 680                 685             


Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr Ser Asp 
    690                 695                 700                 


Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val Gly Lys 
705                 710                 715                 720 


Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys 
                725                 730                 735     


Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg 
            740                 745                 750         


Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys Lys Trp 
        755                 760                 765             


Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu Val Ile 
    770                 775                 780                 


Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu Gly Lys 
785                 790                 795                 800 


Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile 
                805                 810                 815     


Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
            820                 825                 


<210>  705
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  705

Met Lys Phe Val Tyr Lys Glu Glu His Pro Phe Glu Lys Arg Arg Ser 
1               5                   10                  15      


Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Ala Pro Lys Ala Arg Ile Gly Asp Leu Asp Lys Lys Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Leu Thr Val Gly Gln Phe Tyr Phe Leu Ile 
    50                  55                  60                  


Arg Lys Arg Ile His Leu Arg Ala Glu Asp Ala Leu Phe Phe Phe Val 
65                  70                  75                  80  


Asn Asn Val Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Gln 
                85                  90                  95      


Glu His His Glu Glu Asp Phe Phe Leu Tyr Ile Ala Tyr Ser Asp Glu 
            100                 105                 110         


Ser Val Tyr Gly Leu 
        115         


<210>  706
<211>  1684
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys 
            20                  25                  30          


Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys 
        35                  40                  45              


Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr 
    50                  55                  60                  


Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys 
                85                  90                  95      


Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys 
            100                 105                 110         


Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val 
        115                 120                 125             


Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys 
    130                 135                 140                 


Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met 
145                 150                 155                 160 


Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser 
                165                 170                 175     


Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro 
            180                 185                 190         


Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr 
        195                 200                 205             


Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu 
    210                 215                 220                 


Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met 
                245                 250                 255     


Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys 
            260                 265                 270         


Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu 
        275                 280                 285             


Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys 
    290                 295                 300                 


Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu 
305                 310                 315                 320 


Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His 
                325                 330                 335     


Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys 
            340                 345                 350         


Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp 
        355                 360                 365             


Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu 
    370                 375                 380                 


Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val 
385                 390                 395                 400 


Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys 
                405                 410                 415     


Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln 
            420                 425                 430         


His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser 
        435                 440                 445             


Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu 
    450                 455                 460                 


Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr 
465                 470                 475                 480 


Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu 
                485                 490                 495     


Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln 
            500                 505                 510         


Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr 
        515                 520                 525             


Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn 
    530                 535                 540                 


Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr 
545                 550                 555                 560 


Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser 
                565                 570                 575     


Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu 
            580                 585                 590         


Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu 
        595                 600                 605             


Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile 
    610                 615                 620                 


Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu 
625                 630                 635                 640 


Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu 
                645                 650                 655     


Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln 
            660                 665                 670         


Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys 
        675                 680                 685             


Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu 
    690                 695                 700                 


Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu 
705                 710                 715                 720 


Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu 
                725                 730                 735     


Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys 
            740                 745                 750         


Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser 
        755                 760                 765             


Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln 
    770                 775                 780                 


Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu 
785                 790                 795                 800 


Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys 
                805                 810                 815     


Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu 
            820                 825                 830         


Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu 
        835                 840                 845             


Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met 
    850                 855                 860                 


Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile 
865                 870                 875                 880 


Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn 
                885                 890                 895     


Glu Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu 
            900                 905                 910         


Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu 
        915                 920                 925             


Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser 
    930                 935                 940                 


Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys 
945                 950                 955                 960 


Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys 
                965                 970                 975     


Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys 
            980                 985                 990         


Glu Glu Leu Glu Ser Leu Arg Ser  Glu Lys Asp Gln Leu  Ser Ala Ser 
        995                 1000                 1005             


Met Arg  Asp Leu Ile Gln Gly  Ala Glu Ser Tyr Lys  Asn Leu Leu 
    1010                 1015                 1020             


Leu Glu  Tyr Glu Lys Gln Ser  Glu Gln Leu Asp Val  Glu Lys Glu 
    1025                 1030                 1035             


Arg Ala  Asn Asn Phe Glu His  Arg Ile Glu Asp Leu  Thr Arg Gln 
    1040                 1045                 1050             


Leu Arg  Asn Ser Thr Leu Gln  Cys Glu Thr Ile Asn  Ser Asp Asn 
    1055                 1060                 1065             


Glu Asp  Leu Leu Ala Arg Ile  Glu Thr Leu Gln Ser  Asn Ala Lys 
    1070                 1075                 1080             


Leu Leu  Glu Val Gln Ile Leu  Glu Val Gln Arg Ala  Lys Ala Met 
    1085                 1090                 1095             


Val Asp  Lys Glu Leu Glu Ala  Glu Lys Leu Gln Lys  Glu Gln Lys 
    1100                 1105                 1110             


Ile Lys  Glu His Ala Thr Thr  Val Asn Glu Leu Glu  Glu Leu Gln 
    1115                 1120                 1125             


Val Gln  Leu Gln Lys Gln Lys  Lys Gln Leu Gln Lys  Thr Met Gln 
    1130                 1135                 1140             


Glu Leu  Glu Leu Val Lys Lys  Asp Ala Gln Gln Thr  Thr Leu Met 
    1145                 1150                 1155             


Asn Met  Glu Ile Ala Asp Tyr  Glu Arg Leu Met Lys  Glu Leu Asn 
    1160                 1165                 1170             


Gln Lys  Leu Thr Asn Lys Asn  Asn Lys Ile Glu Asp  Leu Glu Gln 
    1175                 1180                 1185             


Glu Ile  Lys Ile Gln Lys Gln  Lys Gln Glu Thr Leu  Gln Glu Glu 
    1190                 1195                 1200             


Ile Thr  Ser Leu Gln Ser Ser  Val Gln Gln Tyr Glu  Glu Lys Asn 
    1205                 1210                 1215             


Thr Lys  Ile Lys Gln Leu Leu  Val Lys Thr Lys Lys  Glu Leu Ala 
    1220                 1225                 1230             


Asp Ser  Lys Gln Ala Glu Thr  Asp His Leu Ile Leu  Gln Ala Ser 
    1235                 1240                 1245             


Leu Lys  Gly Glu Leu Glu Ala  Ser Gln Gln Gln Val  Glu Val Tyr 
    1250                 1255                 1260             


Lys Ile  Gln Leu Ala Glu Ile  Thr Ser Glu Lys His  Lys Ile His 
    1265                 1270                 1275             


Glu His  Leu Lys Thr Ser Ala  Glu Gln His Gln Arg  Thr Leu Ser 
    1280                 1285                 1290             


Ala Tyr  Gln Gln Arg Val Thr  Ala Leu Gln Glu Glu  Cys Arg Ala 
    1295                 1300                 1305             


Ala Lys  Ala Glu Gln Ala Thr  Val Thr Ser Glu Phe  Glu Ser Tyr 
    1310                 1315                 1320             


Lys Val  Arg Val His Asn Val  Leu Lys Gln Gln Lys  Asn Lys Ser 
    1325                 1330                 1335             


Met Ser  Gln Ala Glu Thr Glu  Gly Ala Lys Gln Glu  Arg Glu His 
    1340                 1345                 1350             


Leu Glu  Met Leu Ile Asp Gln  Leu Lys Ile Lys Leu  Gln Asp Ser 
    1355                 1360                 1365             


Gln Asn  Asn Leu Gln Ile Asn  Val Ser Glu Leu Gln  Thr Leu Gln 
    1370                 1375                 1380             


Ser Glu  His Asp Thr Leu Leu  Glu Arg His Asn Lys  Met Leu Gln 
    1385                 1390                 1395             


Glu Thr  Val Ser Lys Glu Ala  Glu Leu Arg Glu Lys  Leu Cys Ser 
    1400                 1405                 1410             


Ile Gln  Ser Glu Asn Met Met  Met Lys Ser Glu His  Thr Gln Thr 
    1415                 1420                 1425             


Val Ser  Gln Leu Thr Ser Gln  Asn Glu Val Leu Arg  Asn Ser Phe 
    1430                 1435                 1440             


Arg Asp  Gln Val Arg His Leu  Gln Glu Glu His Arg  Lys Thr Val 
    1445                 1450                 1455             


Glu Thr  Leu Gln Gln Gln Leu  Ser Lys Met Glu Ala  Gln Leu Phe 
    1460                 1465                 1470             


Gln Leu  Lys Asn Glu Pro Thr  Thr Arg Ser Pro Val  Ser Ser Gln 
    1475                 1480                 1485             


Gln Ser  Leu Lys Asn Leu Arg  Glu Arg Arg Asn Thr  Asp Leu Pro 
    1490                 1495                 1500             


Leu Leu  Asp Met His Thr Val  Thr Arg Glu Glu Gly  Glu Gly Met 
    1505                 1510                 1515             


Glu Thr  Thr Asp Thr Glu Ser  Val Ser Ser Ala Ser  Thr Tyr Thr 
    1520                 1525                 1530             


Gln Ser  Leu Glu Gln Leu Leu  Asn Ser Pro Glu Thr  Lys Leu Glu 
    1535                 1540                 1545             


Pro Pro  Leu Trp His Ala Glu  Phe Thr Lys Glu Glu  Leu Val Gln 
    1550                 1555                 1560             


Lys Leu  Ser Ser Thr Thr Lys  Ser Ala Asp His Leu  Asn Gly Leu 
    1565                 1570                 1575             


Leu Arg  Glu Thr Glu Ala Thr  Asn Ala Ile Leu Met  Glu Gln Ile 
    1580                 1585                 1590             


Lys Leu  Leu Lys Ser Glu Ile  Arg Arg Leu Glu Arg  Asn Gln Glu 
    1595                 1600                 1605             


Arg Glu  Lys Ser Ala Ala Asn  Leu Glu Tyr Leu Lys  Asn Val Leu 
    1610                 1615                 1620             


Leu Gln  Phe Ile Phe Leu Lys  Pro Gly Ser Glu Arg  Glu Arg Leu 
    1625                 1630                 1635             


Leu Pro  Val Ile Asn Thr Met  Leu Gln Leu Ser Pro  Glu Glu Lys 
    1640                 1645                 1650             


Gly Lys  Leu Ala Ala Val Ala  Gln Gly Glu Glu Glu  Asn Ala Ser 
    1655                 1660                 1665             


Arg Ser  Ser Gly Trp Ala Ser  Tyr Leu His Ser Trp  Ser Gly Leu 
    1670                 1675                 1680             


Arg 
    


<210>  707
<211>  970
<212>  PRT
<213>  Homo sapiens

<400>  707

Met Asp Ala Ala Glu Pro Gly Leu Pro Pro Gly Pro Glu Gly Arg Lys 
1               5                   10                  15      


Arg Tyr Ser Asp Ile Phe Arg Ser Leu Asp Asn Leu Glu Ile Ser Leu 
            20                  25                  30          


Gly Asn Val Thr Leu Glu Met Leu Ala Gly Asp Pro Leu Leu Ser Glu 
        35                  40                  45              


Asp Pro Glu Pro Asp Lys Thr Pro Thr Ala Thr Val Thr Asn Glu Ala 
    50                  55                  60                  


Ser Cys Trp Ser Gly Pro Ser Pro Glu Gly Pro Val Pro Leu Thr Gly 
65                  70                  75                  80  


Glu Glu Leu Asp Leu Arg Leu Ile Arg Thr Lys Gly Gly Val Asp Ala 
                85                  90                  95      


Ala Leu Glu Tyr Ala Lys Thr Trp Ser Arg Tyr Ala Lys Glu Leu Leu 
            100                 105                 110         


Ala Trp Thr Glu Lys Arg Ala Ser Tyr Glu Leu Glu Phe Ala Lys Ser 
        115                 120                 125             


Thr Met Lys Ile Ala Glu Ala Gly Lys Val Ser Ile Gln Gln Gln Ser 
    130                 135                 140                 


His Met Pro Leu Gln Tyr Ile Tyr Thr Leu Phe Leu Glu His Asp Leu 
145                 150                 155                 160 


Ser Leu Gly Thr Leu Ala Met Glu Thr Val Ala Gln Gln Lys Arg Asp 
                165                 170                 175     


Tyr Tyr Gln Pro Leu Ala Ala Lys Arg Thr Glu Ile Glu Lys Trp Arg 
            180                 185                 190         


Lys Glu Phe Lys Glu Gln Trp Met Lys Glu Gln Lys Arg Met Asn Glu 
        195                 200                 205             


Ala Val Gln Ala Leu Arg Arg Ala Gln Leu Gln Tyr Val Gln Arg Ser 
    210                 215                 220                 


Glu Asp Leu Arg Ala Arg Ser Gln Gly Ser Pro Glu Asp Ser Ala Pro 
225                 230                 235                 240 


Gln Ala Ser Pro Gly Pro Ser Lys Gln Gln Glu Arg Arg Arg Arg Ser 
                245                 250                 255     


Arg Glu Glu Ala Gln Ala Lys Ala Gln Glu Ala Glu Ala Leu Tyr Gln 
            260                 265                 270         


Ala Cys Val Arg Glu Ala Asn Ala Arg Gln Gln Asp Leu Glu Ile Ala 
        275                 280                 285             


Lys Gln Arg Ile Val Ser His Val Arg Lys Leu Val Phe Gln Gly Asp 
    290                 295                 300                 


Glu Val Leu Arg Arg Val Thr Leu Ser Leu Phe Gly Leu Arg Gly Ala 
305                 310                 315                 320 


Gln Ala Glu Arg Gly Pro Arg Ala Phe Ala Ala Leu Ala Glu Cys Cys 
                325                 330                 335     


Ala Pro Phe Glu Pro Gly Gln Arg Tyr Gln Glu Phe Val Arg Ala Leu 
            340                 345                 350         


Arg Pro Glu Ala Pro Pro Pro Pro Pro Pro Ala Phe Ser Phe Gln Glu 
        355                 360                 365             


Phe Leu Pro Ser Leu Asn Ser Ser Pro Leu Asp Ile Arg Lys Lys Leu 
    370                 375                 380                 


Ser Gly Pro Leu Pro Pro Arg Leu Asp Glu Asn Ser Ala Glu Pro Gly 
385                 390                 395                 400 


Pro Trp Glu Asp Pro Gly Thr Gly Trp Arg Trp Gln Gly Thr Pro Gly 
                405                 410                 415     


Pro Thr Pro Gly Ser Asp Val Asp Ser Val Gly Gly Gly Ser Glu Ser 
            420                 425                 430         


Arg Ser Leu Asp Ser Pro Thr Ser Ser Pro Gly Ala Gly Thr Arg Gln 
        435                 440                 445             


Leu Val Lys Ala Ser Ser Thr Gly Thr Glu Ser Ser Asp Asp Phe Glu 
    450                 455                 460                 


Glu Arg Asp Pro Asp Leu Gly Asp Gly Leu Glu Asn Gly Leu Gly Ser 
465                 470                 475                 480 


Pro Phe Gly Lys Trp Thr Leu Ser Ser Ala Ala Gln Thr His Gln Leu 
                485                 490                 495     


Arg Arg Leu Arg Gly Pro Ala Lys Cys Arg Glu Cys Glu Ala Phe Met 
            500                 505                 510         


Val Ser Gly Thr Glu Cys Glu Glu Cys Phe Leu Thr Cys His Lys Arg 
        515                 520                 525             


Cys Leu Glu Thr Leu Leu Ile Leu Cys Gly His Arg Arg Leu Pro Ala 
    530                 535                 540                 


Arg Thr Pro Leu Phe Gly Val Asp Phe Leu Gln Leu Pro Arg Asp Phe 
545                 550                 555                 560 


Pro Glu Glu Val Pro Phe Val Val Thr Lys Cys Thr Ala Glu Ile Glu 
                565                 570                 575     


His Arg Ala Leu Asp Val Gln Gly Ile Tyr Arg Val Ser Gly Ser Arg 
            580                 585                 590         


Val Arg Val Glu Arg Leu Cys Gln Ala Phe Glu Asn Gly Arg Ala Leu 
        595                 600                 605             


Val Glu Leu Ser Gly Asn Ser Pro His Asp Val Ser Ser Val Leu Lys 
    610                 615                 620                 


Arg Phe Leu Gln Glu Leu Thr Glu Pro Val Ile Pro Phe His Leu Tyr 
625                 630                 635                 640 


Asp Ala Phe Ile Ser Leu Ala Lys Thr Leu His Ala Asp Pro Gly Asp 
                645                 650                 655     


Asp Pro Gly Thr Pro Ser Pro Ser Pro Glu Val Ile Arg Ser Leu Lys 
            660                 665                 670         


Thr Leu Leu Val Gln Leu Pro Asp Ser Asn Tyr Asn Thr Leu Arg His 
        675                 680                 685             


Leu Val Ala His Leu Phe Arg Val Ala Ala Arg Phe Met Glu Asn Lys 
    690                 695                 700                 


Met Ser Ala Asn Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg 
705                 710                 715                 720 


Pro Pro Asp Gly Pro Arg Ala Ala Ser Ala Ile Pro Val Thr Cys Leu 
                725                 730                 735     


Leu Asp Ser Gly His Gln Ala Gln Leu Val Glu Phe Leu Ile Val His 
            740                 745                 750         


Tyr Glu Gln Ile Phe Gly Met Asp Glu Leu Pro Gln Ala Thr Glu Pro 
        755                 760                 765             


Pro Pro Gln Asp Ser Ser Pro Ala Pro Gly Pro Leu Thr Thr Ser Ser 
    770                 775                 780                 


Gln Pro Pro Pro Pro His Leu Asp Pro Asp Ser Gln Pro Pro Val Leu 
785                 790                 795                 800 


Ala Ser Asp Pro Gly Pro Asp Pro Gln His His Ser Thr Leu Glu Gln 
                805                 810                 815     


His Pro Thr Ala Thr Pro Thr Glu Ile Pro Thr Pro Gln Ser Asp Gln 
            820                 825                 830         


Arg Glu Asp Val Ala Glu Asp Thr Lys Asp Gly Gly Gly Glu Val Ser 
        835                 840                 845             


Ser Gln Gly Pro Glu Asp Ser Leu Leu Gly Thr Gln Ser Arg Gly His 
    850                 855                 860                 


Phe Ser Arg Gln Pro Val Lys Tyr Pro Arg Gly Gly Val Arg Pro Val 
865                 870                 875                 880 


Thr His Gln Leu Ser Ser Leu Ala Leu Val Ala Ser Lys Leu Cys Glu 
                885                 890                 895     


Glu Thr Pro Ile Thr Ser Val Pro Arg Gly Ser Leu Arg Gly Arg Gly 
            900                 905                 910         


Pro Ser Pro Ala Ala Ala Ser Pro Glu Gly Ser Pro Leu Arg Arg Thr 
        915                 920                 925             


Pro Leu Pro Lys His Phe Glu Ile Thr Gln Glu Thr Ala Arg Leu Leu 
    930                 935                 940                 


Ser Lys Leu Asp Ser Glu Ala Val Pro Arg Ala Thr Cys Cys Pro Asp 
945                 950                 955                 960 


Val Gln Pro Glu Glu Ala Glu Asp His Leu 
                965                 970 


<210>  708
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Ser Gly Val Val Arg Thr Leu Ser Arg Cys Leu Leu Pro Ala Glu 
1               5                   10                  15      


Ala Gly Gly Ala Arg Glu Arg Arg Ala Gly Ser Gly Ala Arg Asp Ala 
            20                  25                  30          


Glu Arg Glu Ala Arg Arg Arg Ser Arg Asp Ile Asp Ala Leu Leu Ala 
        35                  40                  45              


Arg Glu Arg Arg Ala Val Arg Arg Leu Val Lys Ile Leu Leu Leu Gly 
    50                  55                  60                  


Ala Gly Glu Ser Gly Lys Ser Thr Phe Leu Lys Gln Met Arg Ile Ile 
65                  70                  75                  80  


His Gly Arg Glu Phe Asp Gln Lys Ala Leu Leu Glu Phe Arg Asp Thr 
                85                  90                  95      


Ile Phe Asp Asn Ile Leu Lys Gly Ser Arg Val Leu Val Asp Ala Arg 
            100                 105                 110         


Asp Lys Leu Gly Ile Pro Trp Gln Tyr Ser Glu Asn Glu Lys His Gly 
        115                 120                 125             


Met Phe Leu Met Ala Phe Glu Asn Lys Ala Gly Leu Pro Val Glu Pro 
    130                 135                 140                 


Ala Thr Phe Gln Leu Tyr Val Pro Ala Leu Ser Ala Leu Trp Arg Asp 
145                 150                 155                 160 


Ser Gly Ile Arg Glu Ala Phe Ser Arg Arg Ser Glu Phe Gln Leu Gly 
                165                 170                 175     


Glu Ser Val Lys Tyr Phe Leu Asp Asn Leu Asp Arg Ile Gly Gln Leu 
            180                 185                 190         


Asn Tyr Phe Pro Ser Lys Gln Asp Ile Leu Leu Ala Arg Lys Ala Thr 
        195                 200                 205             


Lys Gly Ile Val Glu His Asp Phe Val Ile Lys Lys Ile Pro Phe Lys 
    210                 215                 220                 


Met Val Asp Val Gly Gly Gln Arg Ser Gln Arg Gln Lys Trp Phe Gln 
225                 230                 235                 240 


Cys Phe Asp Gly Ile Thr Ser Ile Leu Phe Met Val Ser Ser Ser Glu 
                245                 250                 255     


Tyr Asp Gln Val Leu Met Glu Asp Arg Arg Thr Asn Arg Leu Val Glu 
            260                 265                 270         


Ser Met Asn Ile Phe Glu Thr Ile Val Asn Asn Lys Leu Phe Phe Asn 
        275                 280                 285             


Val Ser Ile Ile Leu Phe Leu Asn Lys Met Asp Leu Leu Val Glu Lys 
    290                 295                 300                 


Val Lys Thr Val Ser Ile Lys Lys His Phe Pro Asp Phe Arg Gly Asp 
305                 310                 315                 320 


Pro His Arg Leu Glu Asp Val Gln Arg Tyr Leu Val Gln Cys Phe Asp 
                325                 330                 335     


Arg Lys Arg Arg Asn Arg Ser Lys Pro Leu Phe His His Phe Thr Thr 
            340                 345                 350         


Ala Ile Asp Thr Glu Asn Val Arg Phe Val Phe His Ala Val Lys Asp 
        355                 360                 365             


Thr Ile Leu Gln Glu Asn Leu Lys Asp Ile Met Leu Gln 
    370                 375                 380     


<210>  709
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  709

Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys 
1               5                   10                  15      


Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr 
                85                  90                  95      


Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu 
            100                 105                 110         


Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr 
        115                 120                 125             


Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr 
145                 150                 155                 160 


Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Glu Tyr Asn Leu Val 
        355                 


<210>  710
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Arg Pro Gln Gln Ala Pro Val Ser Gly Lys Val Phe Ile Gln Arg 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Thr Arg Cys Gln Phe Gln Thr Lys Phe Pro Ala 
            20                  25                  30          


Glu Leu Glu Asn Arg Ile Asp Arg Gln Gln Phe Glu Glu Thr Val Arg 
        35                  40                  45              


Thr Leu Asn Asn Leu Tyr Ala Glu Ala Glu Lys Leu Gly Gly Gln Ser 
    50                  55                  60                  


Tyr Leu Glu Gly Cys Leu Ala Cys Leu Thr Ala Tyr Thr Ile Phe Leu 
65                  70                  75                  80  


Cys Met Glu Thr His Tyr Glu Lys Val Leu Lys Lys Val Ser Lys Tyr 
                85                  90                  95      


Ile Gln Glu Gln Asn Glu Lys Ile Tyr Ala Pro Gln Gly Leu Leu Leu 
            100                 105                 110         


Thr Asp Pro Ile Glu Arg Gly Leu Arg Val Ile Glu Ile Thr Ile Tyr 
        115                 120                 125             


Glu Asp Arg Gly Met Ser Ser Gly Arg 
    130                 135         


<210>  711
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  711

Met Ala Gln His Asp Phe Val Pro Ala Trp Leu Asn Phe Ser Thr Pro 
1               5                   10                  15      


Gln Ser Ala Lys Ser Pro Thr Ala Thr Phe Glu Lys His Gly Glu His 
            20                  25                  30          


Leu Pro Arg Gly Glu Gly Arg Phe Gly Val Ser Arg Arg Arg His Asn 
        35                  40                  45              


Ser Ser Asp Gly Phe Phe Asn Asn Gly Pro Leu Arg Thr Ala Gly Asp 
    50                  55                  60                  


Ser Trp His Gln Pro Ser Leu Phe Arg His Asp Ser Val Asp Ser Gly 
65                  70                  75                  80  


Val Ser Lys Gly Ala Tyr Ala Gly Ile Thr Gly Asn Pro Ser Gly Trp 
                85                  90                  95      


His Ser Ser Ser Arg Gly His Asp Gly Met Ser Gln Arg Ser Gly Gly 
            100                 105                 110         


Gly Thr Gly Asn His Arg His Trp Asn Gly Ser Phe His Ser Arg Lys 
        115                 120                 125             


Gly Cys Ala Phe Gln Glu Lys Pro Pro Met Glu Ile Arg Glu Glu Lys 
    130                 135                 140                 


Lys Glu Asp Lys Val Glu Lys Leu Gln Phe Glu Glu Glu Asp Phe Pro 
145                 150                 155                 160 


Ser Leu Asn Pro Glu Ala Gly Lys Gln His Gln Pro Cys Arg Pro Ile 
                165                 170                 175     


Gly Thr Pro Ser Gly Val Trp Glu Asn Pro Pro Ser Ala Lys Gln Pro 
            180                 185                 190         


Ser Lys Met Leu Val Ile Lys Lys Val Ser Lys Glu Asp Pro Ala Ala 
        195                 200                 205             


Ala Phe Ser Ala Ala Phe Thr Ser Pro Gly Ser His His Ala Asn Gly 
    210                 215                 220                 


Asn Lys Leu Ser Ser Val Val Pro Ser Val Tyr Lys Asn Leu Val Pro 
225                 230                 235                 240 


Lys Pro Val Pro Pro Pro Ser Lys Pro Asn Ala Trp Lys Ala Asn Arg 
                245                 250                 255     


Met Glu His Lys Ser Gly Ser Leu Ser Ser Ser Arg Glu Ser Ala Phe 
            260                 265                 270         


Thr Ser Pro Ile Ser Val Thr Lys Pro Val Val Leu Ala Ser Gly Ala 
        275                 280                 285             


Ala Leu Ser Ser Pro Lys Glu Ser Pro Ser Ser Thr Thr Pro Pro Ile 
    290                 295                 300                 


Glu Ile Ser Ser Ser Arg Leu Thr Lys Leu Thr Arg Arg Thr Thr Asp 
305                 310                 315                 320 


Arg Lys Ser Glu Phe Leu Lys Thr Leu Lys Asp Asp Arg Asn Gly Asp 
                325                 330                 335     


Phe Ser Glu Asn Arg Asp Cys Asp Lys Leu Glu Asp Leu Glu Asp Asn 
            340                 345                 350         


Ser Thr Pro Glu Pro Lys Glu Asn Gly Glu Glu Gly Cys His Gln Asn 
        355                 360                 365             


Gly Leu Ala Leu Pro Val Val Glu Glu Gly Glu Val Leu Ser His Ser 
    370                 375                 380                 


Leu Glu Ala Glu His Arg Leu Leu Lys Ala Met Gly Trp Gln Glu Tyr 
385                 390                 395                 400 


Pro Glu Asn Asp Glu Asn Cys Leu Pro Leu Thr Glu Asp Glu Leu Lys 
                405                 410                 415     


Glu Phe His Met Lys Thr Glu Gln Leu Arg Arg Asn Gly Phe Gly Lys 
            420                 425                 430         


Asn Gly Phe Leu Gln Ser Arg Ser Ser Ser Leu Phe Ser Pro Trp Arg 
        435                 440                 445             


Ser Thr Cys Lys Ala Glu Phe Glu Asp Ser Asp Thr Glu Thr Ser Ser 
    450                 455                 460                 


Ser Glu Thr Ser Asp Asp Asp Ala Trp Lys 
465                 470                 


<210>  712
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Ala Thr Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Thr Ser Gly Gln Glu Lys Pro Thr Glu Gly Pro Arg Asn Thr Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Thr Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Lys Val Asn Thr Pro Phe Leu Lys Ala Leu Val 
                85                  90                  95      


Gln Asn Leu Ser Thr Asn Thr Ala Glu Asp Phe Tyr Phe Ser Leu Glu 
            100                 105                 110         


Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro 
        115                 120                 125             


Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn 
    130                 135                 140                 


Arg Ser Val Val Arg Leu Ala Val Thr Ile Leu Asp Ile Gly Pro Gly 
145                 150                 155                 160 


Thr Leu Phe Lys Gly Pro Arg Leu Gly Leu Gly Asp Gly Ser Gly Val 
                165                 170                 175     


Leu Asn Asn Arg Leu Val Gly Leu Ser Val Gly Gln Met His Val Thr 
            180                 185                 190         


Lys Leu Ala Glu Pro Leu Glu Ile Val Phe Ser His Gln Arg Pro Pro 
        195                 200                 205             


Pro Asn Met Thr Leu Thr Cys Val Phe Trp Asp Val Thr Lys Gly Thr 
    210                 215                 220                 


Thr Gly Asp Trp Ser Ser Glu Gly Cys Ser Thr Glu Val Arg Pro Glu 
225                 230                 235                 240 


Gly Thr Val Cys Cys Cys Asp His Leu Thr Phe Phe Ala Leu Leu Leu 
                245                 250                 255     


Arg Pro Thr Leu Asp Gln Ser Thr Val His Ile Leu Thr Arg Ile Ser 
            260                 265                 270         


Gln Ala Gly Cys Gly Val Ser Met Ile Phe Leu Ala Phe Thr Ile Ile 
        275                 280                 285             


Leu Tyr Ala Phe Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp 
    290                 295                 300                 


Ala Pro Lys Ile His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn 
305                 310                 315                 320 


Leu Ala Phe Leu Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala 
                325                 330                 335     


Ala Cys Trp Ala Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala 
            340                 345                 350         


Phe Thr Trp Met Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val 
        355                 360                 365             


Arg Val Phe Asn Thr Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu 
    370                 375                 380                 


Val Gly Trp Gly Leu Pro Ala Leu Met Val Ile Gly Thr Gly Ser Ala 
385                 390                 395                 400 


Asn Ser Tyr Gly Leu Tyr Thr Ile Arg Asp Arg Glu Asn Arg Thr Ser 
                405                 410                 415     


Leu Glu Leu Cys Trp Phe Arg Glu Gly Thr Thr Met Tyr Ala Leu Tyr 
            420                 425                 430         


Ile Thr Val His Gly Tyr Phe Leu Ile Thr Phe Leu Phe Gly Met Val 
        435                 440                 445             


Val Leu Ala Leu Val Val Trp Lys Ile Phe Thr Leu Ser Arg Ala Thr 
    450                 455                 460                 


Ala Val Lys Glu Arg Gly Lys Asn Arg Lys Lys Val Leu Thr Leu Leu 
465                 470                 475                 480 


Gly Leu Ser Ser Leu Val Gly Val Thr Trp Gly Leu Ala Ile Phe Thr 
                485                 490                 495     


Pro Leu Gly Leu Ser Thr Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu 
            500                 505                 510         


Gln Gly Val Phe Ile Cys Cys Trp Phe Thr Ile Leu Tyr Leu Pro Ser 
        515                 520                 525             


Gln Ser Thr Thr Val Ser Ser Ser Thr Ala Arg Leu Asp Gln Ala His 
    530                 535                 540                 


Ser Ala Ser Gln Glu 
545                 


<210>  713
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  713

Met Pro Ala Leu Leu Glu Arg Pro Lys Leu Ser Asn Ala Met Ala Arg 
1               5                   10                  15      


Ala Leu His Arg His Ile Met Met Glu Arg Glu Arg Lys Arg Gln Glu 
            20                  25                  30          


Glu Glu Glu Val Asp Lys Met Met Glu Gln Lys Met Lys Glu Glu Gln 
        35                  40                  45              


Glu Arg Arg Lys Lys Lys Glu Met Glu Glu Arg Met Ser Leu Glu Glu 
    50                  55                  60                  


Thr Lys Glu Gln Ile Leu Lys Leu Glu Glu Lys Leu Leu Ala Leu Gln 
65                  70                  75                  80  


Glu Glu Lys His Gln Leu Phe Leu Gln Leu Lys Lys Val Leu His Glu 
                85                  90                  95      


Glu Glu Lys Arg Arg Arg Lys Glu Gln Ser Asp Leu Thr Thr Leu Thr 
            100                 105                 110         


Ser Ala Ala Tyr Gln Gln Ser Leu Thr Val His Thr Gly Thr His Leu 
        115                 120                 125             


Leu Ser Met Gln Gly Ser Pro Gly Gly His Asn Arg Pro Gly Thr Leu 
    130                 135                 140                 


Met Ala Ala Asp Arg Ala Lys Gln Met Phe Gly Pro Gln Val Leu Thr 
145                 150                 155                 160 


Thr Arg His Tyr Val Gly Ser Ala Ala Ala Phe Ala Gly Thr Pro Glu 
                165                 170                 175     


His Gly Gln Phe Gln Gly Ser Pro Gly Gly Ala Tyr Gly Thr Ala Gln 
            180                 185                 190         


Pro Pro Pro His Tyr Gly Pro Thr Gln Pro Ala Tyr Ser Pro Ser Gln 
        195                 200                 205             


Gln Leu Arg Ala Pro Ser Ala Phe Pro Ala Val Gln Tyr Leu Ser Gln 
    210                 215                 220                 


Pro Gln Pro Gln Pro Tyr Ala Val His Gly His Phe Gln Pro Thr Gln 
225                 230                 235                 240 


Thr Gly Phe Leu Gln Pro Gly Gly Ala Leu Ser Leu Gln Lys Gln Met 
                245                 250                 255     


Glu His Ala Asn Gln Gln Thr Gly Phe Ser Asp Ser Ser Ser Leu Arg 
            260                 265                 270         


Pro Met His Pro Gln Ala Leu His Pro Ala Pro Gly Leu Leu Ala Ser 
        275                 280                 285             


Pro Gln Leu Pro Val Gln Met Gln Pro Ala Gly Lys Ser Gly Phe Ala 
    290                 295                 300                 


Ala Thr Ser Gln Pro Gly Pro Arg Leu Pro Phe Ile Gln His Ser Gln 
305                 310                 315                 320 


Asn Pro Arg Phe Tyr His Lys 
                325         


<210>  714
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210>  715
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  715

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
1               5                   10                  15      


Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
            20                  25                  30          


Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
        35                  40                  45              


Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
    50                  55                  60                  


Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
65                  70                  75                  80  


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                85                  90                  95      


Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
            100                 105                 110         


Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
        115                 120                 125             


Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
    130                 135                 140                 


Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
145                 150                 155                 160 


Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                165                 170                 175     


Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
            180                 185                 190         


Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
        195                 200                 205             


Tyr Val Thr Pro Val Asn Arg Asn Val 
    210                 215         


<210>  716
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  717
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  717

Met Trp Ser Thr Arg Ser Pro Asn Ser Thr Ala Trp Pro Leu Ser Leu 
1               5                   10                  15      


Glu Pro Asp Pro Gly Met Ala Ser Ala Ser Thr Thr Met His Thr Thr 
            20                  25                  30          


Thr Ile Ala Glu Pro Asp Pro Gly Met Ser Gly Trp Pro Asp Gly Arg 
        35                  40                  45              


Met Glu Thr Ser Thr Pro Thr Ile Met Asp Ile Val Val Ile Ala Gly 
    50                  55                  60                  


Val Ile Ala Ala Val Ala Ile Val Leu Val Ser Leu Leu Phe Val Met 
65                  70                  75                  80  


Leu Arg Tyr Met Tyr Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala 
                85                  90                  95      


Lys Gly Thr Glu Phe Ala Glu Ser Ala Asp Ala Ala Leu Gln Gly Asp 
            100                 105                 110         


Pro Ala Leu Gln Asp Ala Gly Asp Ser Ser Arg Lys Glu Tyr Phe Ile 
        115                 120                 125             


<210>  718
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  718

Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro 
1               5                   10                  15      


Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val 
            20                  25                  30          


Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val 
        35                  40                  45              


Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu 
    50                  55                  60                  


Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val 
65                  70                  75                  80  


Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser 
                85                  90                  95      


Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys 
            100                 105                 110         


Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn 
        115                 120                 125             


Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys 
    130                 135                 140                 


Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys 
145                 150                 155                 160 


Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr 
                165                 170                 175     


Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg 
            180                 185                 190         


Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg 
        195                 200                 205             


Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
    210                 215                 220                 


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
225                 230                 235                 240 


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
                245                 250                 255     


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
            260                 265                 270         


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
        275                 280                 285             


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
    290                 295                 300                 


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
305                 310                 315                 320 


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
                325                 330                 335     


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
            340                 345                 350         


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
        355                 360                 365             


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
    370                 375                 380                 


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
385                 390                 395                 400 


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
                405                 410                 415     


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
            420                 425                 430         


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
        435                 440                 445             


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
    450                 455                 460                 


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
465                 470                 475                 480 


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
                485                 490                 495     


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
            500                 505                 510         


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
        515                 520                 525             


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
    530                 535                 540                 


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
545                 550                 555                 560 


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
                565                 570                 575     


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
            580                 585                 590         


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
        595                 600                 605             


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
    610                 615                 620                 


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
625                 630                 635                 640 


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
                645                 650                 655     


Leu 
    


<210>  719
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  719

Leu Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp 
65                  70                  75                  80  


Ile Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp 
                85                  90                  95      


Leu Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly 
            100                 105                 110         


Glu Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp 
    130                 135                 140                 


Phe Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala 
145                 150                 155                 160 


Pro Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly 
            180                 185                 190         


Asp Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe 
        195                 200                 205             


Tyr Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp 
    210                 215                 220                 


His Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro 
225                 230                 235                 240 


Cys Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu 
                245                 250                 255     


Ile Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln 
            260                 265                 270         


Phe Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala 
        275                 280                 285             


Val Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala 
    290                 295                 300                 


Glu Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu 
305                 310                 315                 320 


His Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met 
                325                 330                 335     


Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys 
            340                 345                 350         


Gln Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly 
        355                 360                 365             


Met Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala 
    370                 375                 380                 


Ala Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe 
385                 390                 395                 400 


Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly 
                405                 410                 415     


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly 
            420                 425                 430         


Ser Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met 
        435                 440                 445             


Glu Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro 
    450                 455                 460                 


Glu Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu 
465                 470                 475                 480 


Asn Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn 
                485                 490                 495     


Arg Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp 
            500                 505                 510         


Asp Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 525     


<210>  720
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210>  721
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  721

Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser 
        355                 360                 365             


Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln 
    370                 375                 380                 


Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His 
385                 390                 395                 400 


Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys 
                405                 410                 415     


Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser 
            420                 425                 430         


Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr 
        435                 440                 445             


Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp 
    450                 455                 460                 


Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser 
465                 470                 475                 480 


Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn 
                485                 490                 495     


Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser 
            500                 505                 510         


Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu 
        515                 520                 525             


Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser 
    530                 535                 540                 


Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys 
545                 550                 555                 560 


Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn 
                565                 570                 575     


Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu 
            580                 585                 590         


Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Asp Asn His 
        595                 600                 605             


Leu Ile Pro Ala Glu Thr Pro Ser Pro Val Ile Phe Ser Asp Phe Pro 
    610                 615                 620                 


Phe Ile Phe Asn Ser Leu Ser Lys Ile Lys Leu Leu Gln Ala Asp Ser 
625                 630                 635                 640 


His Ile Lys Met Gln Met Ser Glu Lys Lys Ala Tyr Met Leu Met His 
                645                 650                 655     


Glu Thr Ile Leu Gln Lys Lys Asp Glu Phe Pro Pro Ser Pro Arg Phe 
            660                 665                 670         


Ile Leu Arg Val Arg Arg Ser Arg Leu Val Lys Asp Ala Leu Arg Gln 
        675                 680                 685             


Leu Ser Gln Ala Glu Ala Thr Asp Phe Cys Lys Val Leu Val Val Glu 
    690                 695                 700                 


Phe Ile Asn Glu Ile Cys Pro Glu Ser Gly Gly Val Ser Ser Glu Phe 
705                 710                 715                 720 


Phe His Cys Met Phe Glu Glu Met Thr Lys Pro Glu Tyr Gly Met Phe 
                725                 730                 735     


Met Tyr Pro Glu Met Gly Ser Cys Met Trp Phe Pro Ala Lys Pro Lys 
            740                 745                 750         


Pro Glu Lys Lys Arg Tyr Phe Leu Phe Gly Met Leu Cys Gly Leu Ser 
        755                 760                 765             


Leu Phe Asn Leu Asn Val Ala Asn Leu Pro Phe Pro Leu Ala Leu Tyr 
    770                 775                 780                 


Lys Lys Leu Leu Asp Gln Lys Pro Ser Leu Glu Asp Leu Lys Glu Leu 
785                 790                 795                 800 


Ser Pro Arg Leu Gly Lys Ser Leu Gln Glu Val Leu Asp Asp Ala Ala 
                805                 810                 815     


Asp Asp Ile Gly Asp Ala Leu Cys Ile Arg Phe Ser Ile His Trp Asp 
            820                 825                 830         


Gln Asn Asp Val Asp Leu Ile Pro Asn Gly Ile Ser Ile Pro Val Asp 
        835                 840                 845             


Gln Thr Asn Lys Arg Asp Tyr Val Ser Lys Tyr Ile Asp Tyr Ile Phe 
    850                 855                 860                 


Asn Val Ser Val Lys Ala Val Tyr Glu Glu Phe Gln Arg Gly Phe Tyr 
865                 870                 875                 880 


Arg Val Cys Glu Lys Glu Ile Leu Arg His Phe Tyr Pro Glu Glu Leu 
                885                 890                 895     


Met Thr Ala Ile Ile Gly Asn Thr Asp Tyr Asp Trp Lys Gln Phe Glu 
            900                 905                 910         


Gln Asn Ser Lys Tyr Glu Gln Gly Tyr Gln Lys Ser His Pro Thr Ile 
        915                 920                 925             


Gln Leu Phe Trp Lys Ala Phe His Lys Leu Thr Leu Asp Glu Lys Lys 
    930                 935                 940                 


Lys Phe Leu Phe Phe Leu Thr Gly Arg Asp Arg Leu His Ala Arg Gly 
945                 950                 955                 960 


Ile Gln Lys Met Glu Ile Val Phe Arg Cys Pro Glu Thr Phe Ser Glu 
                965                 970                 975     


Arg Asp His Pro Thr Ser Ile Thr Cys His Asn Ile Leu Ser Leu Pro 
            980                 985                 990         


Lys Tyr Ser Thr Met Glu Arg Met  Glu Glu Ala Leu Gln  Val Ala Ile 
        995                 1000                 1005             


Asn Asn  Asn Arg Gly Phe Val  Ser Pro Met Leu Thr  Gln Ser 
    1010                 1015                 1020         


<210>  722
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Ser Gly Ala Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser 
1               5                   10                  15      


Val Leu Ser Ala Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp 
            20                  25                  30          


Ala Gln Ala Ala Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu 
        35                  40                  45              


Leu Lys Met Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp 
    50                  55                  60                  


Thr Asn Leu Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu 
65                  70                  75                  80  


Phe Gln Val Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro 
                85                  90                  95      


Ser Ala Ala Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln 
            100                 105                 110         


Leu Asn Asp Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg 
        115                 120                 125             


Phe Gly Glu Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn 
    130                 135                 140                 


Gly Val Ser Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val 
145                 150                 155                 160 


Asp Ser Asn Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val 
                165                 170                 175     


Ile Ile Val Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe 
            180                 185                 190         


Asn Asn Trp Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu 
        195                 200                 205             


Ile Asn Ser Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly 
    210                 215                 220                 


Asp Val Gln Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu 
225                 230                 235                 240 


Arg Ser Val Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe 
                245                 250                 255     


Val Asn Tyr Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp 
            260                 265                 270         


Asn Gly Leu Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile 
        275                 280                 285             


Met Gly Ser Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly 
    290                 295                 300                 


Cys Ser Lys Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu 
305                 310                 315                 320 


Leu Ile Cys Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly 
                325                 330                 335     


Pro Leu Ser Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu 
            340                 345                 350         


Gly Val Thr Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys 
        355                 360                 365             


Pro Val Pro Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg 
    370                 375                 380                 


Asp Ile Thr Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu 
385                 390                 395                 400 


Gly Leu Trp Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro 
                405                 410                 415     


Thr Gly Tyr Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro 
            420                 425                 430         


Asn Cys Thr Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly 
        435                 440                 445             


Asp Asp His Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr 
    450                 455                 460                 


Glu Val Ala Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile 
465                 470                 475                 480 


Val Met Ala Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr 
                485                 490                 495     


Lys Ala Arg Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys 
            500                 505                 510         


Ile Leu Gly Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu 
        515                 520                 525             


Gly Phe Ile Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr 
    530                 535                 540                 


Thr Leu Ser Ser Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val 
545                 550                 555                 560 


Val Asp Val Lys Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly 
                565                 570                 575     


Met Asn Ser Ile Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr 
            580                 585                 590         


Phe Pro Phe Gln Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His 
        595                 600                 605             


Leu Thr Gln Asn Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr 
    610                 615                 620                 


Ile Leu Tyr Arg Lys Lys Ile Phe Trp Lys Ile 
625                 630                 635 


<210>  723
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  723

Met Gln Tyr Pro His Pro Gly Pro Ala Ala Gly Ala Val Gly Val Pro 
1               5                   10                  15      


Leu Tyr Ala Pro Thr Pro Leu Leu Gln Pro Ala His Pro Thr Pro Phe 
            20                  25                  30          


Tyr Ile Glu Asp Ile Leu Gly Arg Gly Pro Ala Ala Pro Thr Pro Ala 
        35                  40                  45              


Pro Thr Leu Pro Ser Pro Asn Ser Ser Phe Thr Ser Leu Val Ser Pro 
    50                  55                  60                  


Tyr Arg Thr Pro Val Tyr Glu Pro Thr Pro Ile His Pro Ala Phe Ser 
65                  70                  75                  80  


His His Ser Ala Ala Ala Leu Ala Ala Ala Tyr Gly Pro Gly Gly Phe 
                85                  90                  95      


Gly Gly Pro Leu Tyr Pro Phe Pro Arg Thr Val Asn Asp Tyr Thr His 
            100                 105                 110         


Ala Leu Leu Arg His Asp Pro Leu Gly Lys Pro Leu Leu Trp Ser Pro 
        115                 120                 125             


Phe Leu Gln Arg Pro Leu His Lys Arg Lys Gly Gly Gln Val Arg Phe 
    130                 135                 140                 


Ser Asn Asp Gln Thr Ile Glu Leu Glu Lys Lys Phe Glu Thr Gln Lys 
145                 150                 155                 160 


Tyr Leu Ser Pro Pro Glu Arg Lys Arg Leu Ala Lys Met Leu Gln Leu 
                165                 170                 175     


Ser Glu Arg Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Ala Lys Trp 
            180                 185                 190         


Arg Arg Leu Lys Gln Glu Asn Pro Gln Ser Asn Lys Lys Glu Glu Leu 
        195                 200                 205             


Glu Ser Leu Asp Ser Ser Cys Asp Gln Arg Gln Asp Leu Pro Ser Glu 
    210                 215                 220                 


Gln Asn Lys Gly Ala Ser Leu Asp Ser Ser Gln Cys Ser Pro Ser Pro 
225                 230                 235                 240 


Ala Ser Gln Glu Asp Leu Glu Ser Glu Ile Ser Glu Asp Ser Asp Gln 
                245                 250                 255     


Glu Val Asp Ile Glu Gly Asp Lys Ser Tyr Phe Asn Ala Gly 
            260                 265                 270 


<210>  724
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  724

Met Asp Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro 
1               5                   10                  15      


Lys Val Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu 
            20                  25                  30          


Arg Glu Ser Phe Glu Arg Thr Gln Thr Val Ser Ile Asn Lys Ala Ile 
        35                  40                  45              


Asn Thr Gln Glu Val Ala Val Lys Glu Lys His Ala Arg Thr Cys Ile 
    50                  55                  60                  


Leu Gly Thr His His Glu Lys Gly Ala Gln Thr Phe Trp Ser Val Val 
65                  70                  75                  80  


Asn Arg Leu Pro Leu Ser Ser Asn Ala Val Leu Cys Trp Lys Phe Cys 
                85                  90                  95      


His Val Phe His Lys Leu Leu Arg Asp Gly His Pro Asn Val Leu Lys 
            100                 105                 110         


Asp Ser Leu Arg Tyr Arg Asn Glu Leu Ser Asp Met Ser Arg Met Trp 
        115                 120                 125             


Gly His Leu Ser Glu Gly Tyr Gly Gln Leu Cys Ser Ile Tyr Leu Lys 
    130                 135                 140                 


Leu Leu Arg Thr Lys Met Glu Tyr His Thr Lys Asn Pro Arg Phe Pro 
145                 150                 155                 160 


Gly Asn Leu Gln Met Ser Asp Arg Gln Leu Asp Glu Ala Gly Glu Ser 
                165                 170                 175     


Asp Val Asn Asn Phe Phe Gln Leu Thr Val Glu Met Phe Asp Tyr Leu 
            180                 185                 190         


Glu Cys Glu Leu Asn Leu Phe Gln Thr Val Phe Asn Ser Leu Asp Met 
        195                 200                 205             


Ser Arg Ser Val Ser Val Thr Ala Ala Gly Gln Cys Arg Leu Ala Pro 
    210                 215                 220                 


Leu Ile Gln Val Ile Leu Asp Cys Ser His Leu Tyr Asp Tyr Thr Val 
225                 230                 235                 240 


Lys Leu Leu Phe Lys Leu His Ser Cys Leu Pro Ala Asp Thr Leu Gln 
                245                 250                 255     


Gly His Arg Asp Arg Phe Met Glu Gln Phe Thr Lys Leu Lys Asp Leu 
            260                 265                 270         


Phe Tyr Arg Ser Ser Asn Leu Gln Tyr Phe Lys Arg Leu Ile Gln Ile 
        275                 280                 285             


Pro Gln Leu Pro Glu Asn Pro Pro Asn Phe Leu Arg Ala Ser Ala Leu 
    290                 295                 300                 


Ser Glu His Ile Ser Pro Val Val Val Ile Pro Ala Glu Ala Ser Ser 
305                 310                 315                 320 


Pro Asp Ser Glu Pro Val Leu Glu Lys Asp Asp Leu Met Asp Met Asp 
                325                 330                 335     


Ala Ser Gln Gln Asn Leu Phe Asp Asn Lys Phe Asp Asp Ile Phe Gly 
            340                 345                 350         


Ser Ser Phe Ser Ser Asp Pro Phe Asn Phe Asn Ser Gln Asn Gly Val 
        355                 360                 365             


Asn Lys Asp Glu Lys Asp His Leu Ile Glu Arg Leu Tyr Arg Glu Ile 
    370                 375                 380                 


Ser Gly Leu Lys Ala Gln Leu Glu Asn Met Lys Thr Glu Ser Gln Arg 
385                 390                 395                 400 


Val Val Leu Gln Leu Lys Gly His Val Ser Glu Leu Glu Ala Asp Leu 
                405                 410                 415     


Ala Glu Gln Gln His Leu Arg Gln Gln Ala Ala Asp Asp Cys Glu Phe 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Leu Arg Arg Gln Arg Glu Asp Thr Glu 
        435                 440                 445             


Lys Ala Gln Arg Ser Leu Ser Glu Ile Glu Arg Lys Ala Gln Ala Asn 
    450                 455                 460                 


Glu Gln Arg Tyr Ser Lys Leu Lys Glu Lys Tyr Ser Glu Leu Val Gln 
465                 470                 475                 480 


Asn His Ala Asp Leu Leu Arg Lys Asn Ala Glu Val Thr Lys Gln Val 
                485                 490                 495     


Ser Met Ala Arg Gln Ala Gln Val Asp Leu Glu Arg Glu Lys Lys Glu 
            500                 505                 510         


Leu Glu Asp Ser Leu Glu Arg Ile Ser Asp Gln Gly Gln Arg Lys Thr 
        515                 520                 525             


Gln Glu Gln Leu Glu Val Leu Glu Ser Leu Lys Gln Glu Leu Ala Thr 
    530                 535                 540                 


Ser Gln Arg Glu Leu Gln Val Leu Gln Gly Ser Leu Glu Thr Ser Ala 
545                 550                 555                 560 


Gln Ser Glu Ala Asn Trp Ala Ala Glu Phe Ala Glu Leu Glu Lys Glu 
                565                 570                 575     


Arg Asp Ser Leu Val Ser Gly Ala Ala His Arg Glu Glu Glu Leu Ser 
            580                 585                 590         


Ala Leu Arg Lys Glu Leu Gln Asp Thr Gln Leu Lys Leu Ala Ser Thr 
        595                 600                 605             


Glu Glu Ser Met Cys Gln Leu Ala Lys Asp Gln Arg Lys Met Leu Leu 
    610                 615                 620                 


Val Gly Ser Arg Lys Ala Ala Glu Gln Val Ile Gln Asp Ala Leu Asn 
625                 630                 635                 640 


Gln Leu Glu Glu Pro Pro Leu Ile Ser Cys Ala Gly Ser Ala Asp His 
                645                 650                 655     


Leu Leu Ser Thr Val Thr Ser Ile Ser Ser Cys Ile Glu Gln Leu Glu 
            660                 665                 670         


Lys Ser Trp Ser Gln Tyr Leu Ala Cys Pro Glu Asp Ile Ser Gly Leu 
        675                 680                 685             


Leu His Ser Ile Thr Leu Leu Ala His Leu Thr Ser Asp Ala Ile Ala 
    690                 695                 700                 


His Gly Ala Thr Thr Cys Leu Arg Ala Pro Pro Glu Pro Ala Asp Ser 
705                 710                 715                 720 


Leu Thr Glu Ala Cys Lys Gln Tyr Gly Arg Glu Thr Leu Ala Tyr Leu 
                725                 730                 735     


Ala Ser Leu Glu Glu Glu Gly Ser Leu Glu Asn Ala Asp Ser Thr Ala 
            740                 745                 750         


Met Arg Asn Cys Leu Ser Lys Ile Lys Ala Ile Gly Glu Glu Leu Leu 
        755                 760                 765             


Pro Arg Gly Leu Asp Ile Lys Gln Glu Glu Leu Gly Asp Leu Val Asp 
    770                 775                 780                 


Lys Glu Met Ala Ala Thr Ser Ala Ala Ile Glu Thr Ala Thr Ala Arg 
785                 790                 795                 800 


Ile Glu Glu Met Leu Ser Lys Ser Arg Ala Gly Asp Thr Gly Val Lys 
                805                 810                 815     


Leu Glu Val Asn Glu Arg Ile Leu Gly Cys Cys Thr Ser Leu Met Gln 
            820                 825                 830         


Ala Ile Gln Val Leu Ile Val Ala Ser Lys Asp Leu Gln Arg Glu Ile 
        835                 840                 845             


Val Glu Ser Gly Arg Gly Thr Ala Ser Pro Lys Glu Phe Tyr Ala Lys 
    850                 855                 860                 


Asn Ser Arg Trp Thr Glu Gly Leu Ile Ser Ala Ser Lys Ala Val Gly 
865                 870                 875                 880 


Trp Gly Ala Thr Val Met Val Asp Ala Ala Asp Leu Val Val Gln Gly 
                885                 890                 895     


Arg Gly Lys Phe Glu Glu Leu Met Val Cys Ser His Glu Ile Ala Ala 
            900                 905                 910         


Ser Thr Ala Gln Leu Val Ala Ala Ser Lys Val Lys Ala Asp Lys Asp 
        915                 920                 925             


Ser Pro Asn Leu Ala Gln Leu Gln Gln Ala Ser Arg Gly Val Asn Gln 
    930                 935                 940                 


Ala Thr Ala Gly Val Val Ala Ser Thr Ile Ser Gly Lys Ser Gln Ile 
945                 950                 955                 960 


Glu Glu Thr Asp Asn Met Asp Phe Ser Ser Met Thr Leu Thr Gln Ile 
                965                 970                 975     


Lys Arg Gln Glu Met Asp Ser Gln Val Arg Val Leu Glu Leu Glu Asn 
            980                 985                 990         


Glu Leu Gln Lys Glu Arg Gln Lys  Leu Gly Glu Leu Arg  Lys Lys His 
        995                 1000                 1005             


Tyr Glu  Leu Ala Gly Val Ala  Glu Gly Trp Glu Glu  Gly Thr Glu 
    1010                 1015                 1020             


Ala Ser  Pro Pro Thr Leu Gln  Glu Val Val Thr Glu  Lys Glu 
    1025                 1030                 1035         


<210>  725
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  725

Met Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Leu Gln Asp Leu 
1               5                   10                  15      


Arg Glu Asn Thr Glu Phe Thr Asp His Glu Leu Gln Glu Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Lys Asp Cys Pro Thr Gly His Leu Thr Val Asp Glu Phe 
        35                  40                  45              


Lys Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Glu His Val Phe Arg Thr Phe Asp Thr Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys 
                85                  90                  95      


Leu Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asn Gly Tyr Ile Ser Arg Ser Glu Met Leu Glu Ile Val Gln Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr 
    130                 135                 140                 


Pro Glu Lys Arg Thr Asp Lys Ile Phe Arg Gln Met Asp Thr Asn Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp 
                165                 170                 175     


Pro Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln 
            180                 185                 190         


Phe 
    


<210>  726
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Lys Cys Val Leu Val Ala Thr Glu Gly Ala Glu Val Leu Phe Tyr 
1               5                   10                  15      


Trp Thr Asp Gln Glu Phe Glu Glu Ser Leu Arg Leu Lys Phe Gly Gln 
            20                  25                  30          


Ser Glu Asn Glu Glu Glu Glu Leu Pro Ala Leu Glu Asp Gln Leu Ser 
        35                  40                  45              


Thr Leu Leu Ala Pro Val Ile Ile Ser Ser Met Thr Met Leu Glu Lys 
    50                  55                  60                  


Leu Ser Asp Thr Tyr Thr Cys Phe Ser Thr Glu Asn Gly Asn Phe Leu 
65                  70                  75                  80  


Tyr Val Leu His Leu Phe Gly Glu Cys Leu Phe Ile Ala Ile Asn Gly 
                85                  90                  95      


Asp His Thr Glu Ser Glu Gly Asp Leu Arg Arg Lys Leu Tyr Val Leu 
            100                 105                 110         


Lys Tyr Leu Phe Glu Val His Phe Gly Leu Val Thr Val Asp Gly His 
        115                 120                 125             


Leu Ile Arg Lys Glu Leu Arg Pro Pro Asp Leu Ala Gln Arg Val Gln 
    130                 135                 140                 


Leu Trp Glu His Phe Gln Ser Leu Leu Trp Thr Tyr Ser Arg Leu Arg 
145                 150                 155                 160 


Glu Gln Glu Gln Cys Phe Ala Val Glu Ala Leu Glu Arg Leu Ile His 
                165                 170                 175     


Pro Gln Leu Cys Glu Leu Cys Ile Glu Ala Leu Glu Arg His Val Ile 
            180                 185                 190         


Gln Ala Val Asn Thr Ser Pro Glu Arg Gly Gly Glu Glu Ala Leu His 
        195                 200                 205             


Ala Phe Leu Leu Val His Ser Lys Leu Leu Ala Phe Tyr Ser Ser His 
    210                 215                 220                 


Ser Ala Ser Ser Leu Arg Pro Ala Asp Leu Leu Ala Leu Ile Leu Leu 
225                 230                 235                 240 


Val Gln Asp Leu Tyr Pro Ser Glu Ser Thr Ala Glu Asp Asp Ile Gln 
                245                 250                 255     


Pro Ser Pro Arg Arg Ala Arg Ser Ser Gln Asn Ile Pro Val Gln Gln 
            260                 265                 270         


Ala Trp Ser Pro His Ser Thr Gly Pro Thr Gly Gly Ser Ser Ala Glu 
        275                 280                 285             


Thr Glu Thr Asp Ser Phe Ser Leu Pro Glu Glu Tyr Phe Thr Pro Ala 
    290                 295                 300                 


Pro Ser Pro Gly Asp Gln Ser Ser Gly Ser Thr Ile Trp Leu Glu Gly 
305                 310                 315                 320 


Gly Thr Pro Pro Met Asp Ala Leu Gln Ile Ala Glu Asp Thr Leu Gln 
                325                 330                 335     


Thr Leu Val Pro His Cys Pro Val Pro Ser Gly Pro Arg Arg Ile Phe 
            340                 345                 350         


Leu Asp Ala Asn Val Lys Glu Ser Tyr Cys Pro Leu Val Pro His Thr 
        355                 360                 365             


Met Tyr Cys Leu Pro Leu Trp Gln Gly Ile Asn Leu Val Leu Leu Thr 
    370                 375                 380                 


Arg Ser Pro Ser Ala Pro Leu Ala Leu Val Leu Ser Gln Leu Met Asp 
385                 390                 395                 400 


Gly Phe Ser Met Leu Glu Lys Lys Leu Lys Glu Gly Pro Glu Pro Gly 
                405                 410                 415     


Ala Ser Leu Arg Ser Gln Pro Leu Val Gly Asp Leu Arg Gln Arg Met 
            420                 425                 430         


Asp Lys Phe Val Lys Asn Arg Gly Ala Gln Glu Ile Gln Ser Thr Trp 
        435                 440                 445             


Leu Glu Phe Lys Ala Lys Ala Phe Ser Lys Ser Glu Pro Gly Ser Ser 
    450                 455                 460                 


Trp Glu Leu Leu Gln Ala Cys Gly Lys Leu Lys Arg Gln Leu Cys Ala 
465                 470                 475                 480 


Ile Tyr Arg Leu Asn Phe Leu Thr Thr Ala Pro Ser Arg Gly Gly Pro 
                485                 490                 495     


His Leu Pro Gln His Leu Gln Asp Gln Val Gln Arg Leu Met Arg Glu 
            500                 505                 510         


Lys Leu Thr Asp Trp Lys Asp Phe Leu Leu Val Lys Ser Arg Arg Asn 
        515                 520                 525             


Ile Thr Met Val Ser Tyr Leu Glu Asp Phe Pro Gly Leu Val His Phe 
    530                 535                 540                 


Ile Tyr Val Asp Arg Thr Thr Gly Gln Met Val Ala Pro Ser Leu Asn 
545                 550                 555                 560 


Cys Ser Gln Lys Thr Ser Ser Glu Leu Gly Lys Gly Pro Leu Ala Ala 
                565                 570                 575     


Phe Val Lys Thr Lys Val Trp Ser Leu Ile Gln Leu Ala Arg Arg Tyr 
            580                 585                 590         


Leu Gln Lys Gly Tyr Thr Thr Leu Leu Phe Gln Glu Gly Asp Phe Tyr 
        595                 600                 605             


Cys Ser Tyr Phe Leu Trp Phe Glu Asn Asp Met Gly Tyr Lys Leu Gln 
    610                 615                 620                 


Met Ile Glu Val Pro Val Leu Ser Asp Asp Ser Val Pro Ile Gly Met 
625                 630                 635                 640 


Leu Gly Gly Asp Tyr Tyr Arg Lys Leu Leu Arg Tyr Tyr Ser Lys Asn 
                645                 650                 655     


Arg Pro Thr Glu Ala Val Arg Cys Tyr Glu Leu Leu Ala Leu His Leu 
            660                 665                 670         


Ser Val Ile Pro Thr Asp Leu Leu Val Gln Gln Ala Gly Gln Leu Ala 
        675                 680                 685             


Arg Arg Leu Trp Glu Ala Ser Arg Ile Pro Leu Leu 
    690                 695                 700 


<210>  727
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  727

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  728
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210>  729
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  729

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser 
            20                  25                  30          


Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly 
        35                  40                  45              


Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 
    50                  55                  60                  


Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala 
65                  70                  75                  80  


Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 
                85                  90                  95      


Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 
            100                 105                 110         


Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp 
        115                 120                 125             


Glu Glu 
    130 


<210>  730
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  730

Met Ser Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser 
1               5                   10                  15      


Cys Phe Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu 
            20                  25                  30          


Asp Tyr Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg 
        35                  40                  45              


Thr Val Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser 
    50                  55                  60                  


Thr Leu Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val 
65                  70                  75                  80  


Glu Ala Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn 
                85                  90                  95      


Pro Glu Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp 
            100                 105                 110         


Glu Tyr Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys 
        115                 120                 125             


Leu Leu Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu 
    130                 135                 140                 


Thr Ile Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn 
145                 150                 155                 160 


Glu Ser Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn 
                165                 170                 175     


Trp Phe Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu 
            180                 185                 190         


Leu Val Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu 
        195                 200                 205             


Ile Glu Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu 
    210                 215                 220                 


Leu Ser Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met 
225                 230                 235                 240 


Glu Asn Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser 
                245                 250                 255     


Glu Ser Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu 
            260                 265                 270         


Ser Leu Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly 
        275                 280                 285             


Ser Asp Ser Asp Glu Glu Asn Val Ala Ala Arg Ala Ser Pro Glu Pro 
    290                 295                 300                 


Glu Leu Gln Leu Arg Pro Tyr Gln Met Glu Val Ala Gln Pro Ala Leu 
305                 310                 315                 320 


Glu Gly Lys Asn Ile Ile Ile Cys Leu Pro Thr Gly Ser Gly Lys Thr 
                325                 330                 335     


Arg Val Ala Val Tyr Ile Ala Lys Asp His Leu Asp Lys Lys Lys Lys 
            340                 345                 350         


Ala Ser Glu Pro Gly Lys Val Ile Val Leu Val Asn Lys Val Leu Leu 
        355                 360                 365             


Val Glu Gln Leu Phe Arg Lys Glu Phe Gln Pro Phe Leu Lys Lys Trp 
    370                 375                 380                 


Tyr Arg Val Ile Gly Leu Ser Gly Asp Thr Gln Leu Lys Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Val Val Lys Ser Cys Asp Ile Ile Ile Ser Thr Ala Gln Ile 
                405                 410                 415     


Leu Glu Asn Ser Leu Leu Asn Leu Glu Asn Gly Glu Asp Ala Gly Val 
            420                 425                 430         


Gln Leu Ser Asp Phe Ser Leu Ile Ile Ile Asp Glu Cys His His Thr 
        435                 440                 445             


Asn Lys Glu Ala Val Tyr Asn Asn Ile Met Arg His Tyr Leu Met Gln 
    450                 455                 460                 


Lys Leu Lys Asn Asn Arg Leu Lys Lys Glu Asn Lys Pro Val Ile Pro 
465                 470                 475                 480 


Leu Pro Gln Ile Leu Gly Leu Thr Ala Ser Pro Gly Val Gly Gly Ala 
                485                 490                 495     


Thr Lys Gln Ala Lys Ala Glu Glu His Ile Leu Lys Leu Cys Ala Asn 
            500                 505                 510         


Leu Asp Ala Phe Thr Ile Lys Thr Val Lys Glu Asn Leu Asp Gln Leu 
        515                 520                 525             


Lys Asn Gln Ile Gln Glu Pro Cys Lys Lys Phe Ala Ile Ala Asp Ala 
    530                 535                 540                 


Thr Arg Glu Asp Pro Phe Lys Glu Lys Leu Leu Glu Ile Met Thr Arg 
545                 550                 555                 560 


Ile Gln Thr Tyr Cys Gln Met Ser Pro Met Ser Asp Phe Gly Thr Gln 
                565                 570                 575     


Pro Tyr Glu Gln Trp Ala Ile Gln Met Glu Lys Lys Ala Ala Lys Glu 
            580                 585                 590         


Gly Asn Arg Lys Glu Arg Val Cys Ala Glu His Leu Arg Lys Tyr Asn 
        595                 600                 605             


Glu Ala Leu Gln Ile Asn Asp Thr Ile Arg Met Ile Asp Ala Tyr Thr 
    610                 615                 620                 


His Leu Glu Thr Phe Tyr Asn Glu Glu Lys Asp Lys Lys Phe Ala Val 
625                 630                 635                 640 


Ile Glu Asp Asp Ser Asp Glu Gly Gly Asp Asp Glu Tyr Cys Asp Gly 
                645                 650                 655     


Asp Glu Asp Glu Asp Asp Leu Lys Lys Pro Leu Lys Leu Asp Glu Thr 
            660                 665                 670         


Asp Arg Phe Leu Met Thr Leu Phe Phe Glu Asn Asn Lys Met Leu Lys 
        675                 680                 685             


Arg Leu Ala Glu Asn Pro Glu Tyr Glu Asn Glu Lys Leu Thr Lys Leu 
    690                 695                 700                 


Arg Asn Thr Ile Met Glu Gln Tyr Thr Arg Thr Glu Glu Ser Ala Arg 
705                 710                 715                 720 


Gly Ile Ile Phe Thr Lys Thr Arg Gln Ser Ala Tyr Ala Leu Ser Gln 
                725                 730                 735     


Trp Ile Thr Glu Asn Glu Lys Phe Ala Glu Val Gly Val Lys Ala His 
            740                 745                 750         


His Leu Ile Gly Ala Gly His Ser Ser Glu Phe Lys Pro Met Thr Gln 
        755                 760                 765             


Asn Glu Gln Lys Glu Val Ile Ser Lys Phe Arg Thr Gly Lys Ile Asn 
    770                 775                 780                 


Leu Leu Ile Ala Thr Thr Val Ala Glu Glu Gly Leu Asp Ile Lys Glu 
785                 790                 795                 800 


Cys Asn Ile Val Ile Arg Tyr Gly Leu Val Thr Asn Glu Ile Ala Met 
                805                 810                 815     


Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Glu Ser Thr Tyr Val Leu 
            820                 825                 830         


Val Ala His Ser Gly Ser Gly Val Ile Glu His Glu Thr Val Asn Asp 
        835                 840                 845             


Phe Arg Glu Lys Met Met Tyr Lys Ala Ile His Cys Val Gln Asn Met 
    850                 855                 860                 


Lys Pro Glu Glu Tyr Ala His Lys Ile Leu Glu Leu Gln Met Gln Ser 
865                 870                 875                 880 


Ile Met Glu Lys Lys Met Lys Thr Lys Arg Asn Ile Ala Lys His Tyr 
                885                 890                 895     


Lys Asn Asn Pro Ser Leu Ile Thr Phe Leu Cys Lys Asn Cys Ser Val 
            900                 905                 910         


Leu Ala Cys Ser Gly Glu Asp Ile His Val Ile Glu Lys Met His His 
        915                 920                 925             


Val Asn Met Thr Pro Glu Phe Lys Glu Leu Tyr Ile Val Arg Glu Asn 
    930                 935                 940                 


Lys Ala Leu Gln Lys Lys Cys Ala Asp Tyr Gln Ile Asn Gly Glu Ile 
945                 950                 955                 960 


Ile Cys Lys Cys Gly Gln Ala Trp Gly Thr Met Met Val His Lys Gly 
                965                 970                 975     


Leu Asp Leu Pro Cys Leu Lys Ile Arg Asn Phe Val Val Val Phe Lys 
            980                 985                 990         


Asn Asn Ser Thr Lys Lys Gln Tyr  Lys Lys Trp Val Glu  Leu Pro Ile 
        995                 1000                 1005             


Thr Phe  Pro Asn Leu Asp Tyr  Ser Glu Cys Cys Leu  Phe Ser Asp 
    1010                 1015                 1020             


Glu Asp  
    1025 


<210>  731
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  731

Met Gly Thr Ala Ser Arg Ser Asn Ile Ala Arg His Leu Gln Thr Asn 
1               5                   10                  15      


Leu Ile Leu Phe Cys Val Gly Ala Val Gly Ala Cys Thr Leu Ser Val 
            20                  25                  30          


Thr Gln Pro Trp Tyr Leu Glu Val Asp Tyr Thr His Glu Ala Val Thr 
        35                  40                  45              


Ile Lys Cys Thr Phe Ser Ala Thr Gly Cys Pro Ser Glu Gln Pro Thr 
    50                  55                  60                  


Cys Leu Trp Phe Arg Tyr Gly Ala His Gln Pro Glu Asn Leu Cys Leu 
65                  70                  75                  80  


Asp Gly Cys Lys Ser Glu Ala Asp Lys Phe Thr Val Arg Glu Ala Leu 
                85                  90                  95      


Lys Glu Asn Gln Val Ser Leu Thr Val Asn Arg Val Thr Ser Asn Asp 
            100                 105                 110         


Ser Ala Ile Tyr Ile Cys Gly Ile Ala Phe Pro Ser Val Pro Glu Ala 
        115                 120                 125             


Arg Ala Lys Gln Thr Gly Gly Gly Thr Thr Leu Val Val Arg Glu Ile 
    130                 135                 140                 


Lys Leu Leu Ser Lys Glu Leu Arg Ser Phe Leu Thr Ala Leu Val Ser 
145                 150                 155                 160 


Leu Leu Ser Val Tyr Val Thr Gly Val Cys Val Ala Phe Ile Leu Leu 
                165                 170                 175     


Ser Lys Ser Lys Ser Asn Pro Leu Arg Asn Lys Glu Ile Lys Glu Asp 
            180                 185                 190         


Ser Gln Lys Lys Lys Ser Ala Arg Arg Ile Phe Gln Glu Ile Ala Gln 
        195                 200                 205             


Glu Leu Tyr His Lys Arg His Val Glu Thr Asn Gln Gln Ser Glu Lys 
    210                 215                 220                 


Asp Asn Asn Thr Tyr Glu Asn Arg Arg Val Leu Ser Asn Tyr Glu Arg 
225                 230                 235                 240 


Pro 
    


<210>  732
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Ser Trp Ser Pro Ser Leu Thr Thr Gln Thr Cys Gly Ala Trp Glu 
1               5                   10                  15      


Met Lys Glu Arg Leu Gly Thr Gly Gly Phe Gly Asn Val Ile Arg Trp 
            20                  25                  30          


His Asn Gln Glu Thr Gly Glu Gln Ile Ala Ile Lys Gln Cys Arg Gln 
        35                  40                  45              


Glu Leu Ser Pro Arg Asn Arg Glu Arg Trp Cys Leu Glu Ile Gln Ile 
    50                  55                  60                  


Met Arg Arg Leu Thr His Pro Asn Val Val Ala Ala Arg Asp Val Pro 
65                  70                  75                  80  


Glu Gly Met Gln Asn Leu Ala Pro Asn Asp Leu Pro Leu Leu Ala Met 
                85                  90                  95      


Glu Tyr Cys Gln Gly Gly Asp Leu Arg Lys Tyr Leu Asn Gln Phe Glu 
            100                 105                 110         


Asn Cys Cys Gly Leu Arg Glu Gly Ala Ile Leu Thr Leu Leu Ser Asp 
        115                 120                 125             


Ile Ala Ser Ala Leu Arg Tyr Leu His Glu Asn Arg Ile Ile His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Glu Asn Ile Val Leu Gln Gln Gly Glu Gln Arg Leu 
145                 150                 155                 160 


Ile His Lys Ile Ile Asp Leu Gly Tyr Ala Lys Glu Leu Asp Gln Gly 
                165                 170                 175     


Ser Leu Cys Thr Ser Phe Val Gly Thr Leu Gln Tyr Leu Ala Pro Glu 
            180                 185                 190         


Leu Leu Glu Gln Gln Lys Tyr Thr Val Thr Val Asp Tyr Trp Ser Phe 
        195                 200                 205             


Gly Thr Leu Ala Phe Glu Cys Ile Thr Gly Phe Arg Pro Phe Leu Pro 
    210                 215                 220                 


Asn Trp Gln Pro Val Gln Trp His Ser Lys Val Arg Gln Lys Ser Glu 
225                 230                 235                 240 


Val Asp Ile Val Val Ser Glu Asp Leu Asn Gly Thr Val Lys Phe Ser 
                245                 250                 255     


Ser Ser Leu Pro Tyr Pro Asn Asn Leu Asn Ser Val Leu Ala Glu Arg 
            260                 265                 270         


Leu Glu Lys Trp Leu Gln Leu Met Leu Met Trp His Pro Arg Gln Arg 
        275                 280                 285             


Gly Thr Asp Pro Thr Tyr Gly Pro Asn Gly Cys Phe Lys Ala Leu Asp 
    290                 295                 300                 


Asp Ile Leu Asn Leu Lys Leu Val His Ile Leu Asn Met Val Thr Gly 
305                 310                 315                 320 


Thr Ile His Thr Tyr Pro Val Thr Glu Asp Glu Ser Leu Gln Ser Leu 
                325                 330                 335     


Lys Ala Arg Ile Gln Gln Asp Thr Gly Ile Pro Glu Glu Asp Gln Glu 
            340                 345                 350         


Leu Leu Gln Glu Ala Gly Leu Ala Leu Ile Pro Asp Lys Pro Ala Thr 
        355                 360                 365             


Gln Cys Ile Ser Asp Gly Lys Leu Asn Glu Gly His Thr Leu Asp Met 
    370                 375                 380                 


Asp Leu Val Phe Leu Phe Asp Asn Ser Lys Ile Thr Tyr Glu Thr Gln 
385                 390                 395                 400 


Ile Ser Pro Arg Pro Gln Pro Glu Ser Val Ser Cys Ile Leu Gln Glu 
                405                 410                 415     


Pro Lys Arg Asn Leu Ala Phe Phe Gln Leu Arg Lys Val Trp Gly Gln 
            420                 425                 430         


Val Trp His Ser Ile Gln Thr Leu Lys Glu Asp Cys Asn Arg Leu Gln 
        435                 440                 445             


Gln Gly Gln Arg Ala Ala Met Met Asn Leu Leu Arg Asn Asn Ser Cys 
    450                 455                 460                 


Leu Ser Lys Met Lys Asn Ser Met Ala Ser Met Ser Gln Gln Leu Lys 
465                 470                 475                 480 


Ala Lys Leu Asp Phe Phe Lys Thr Ser Ile Gln Ile Asp Leu Glu Lys 
                485                 490                 495     


Tyr Ser Glu Gln Thr Glu Phe Gly Ile Thr Ser Asp Lys Leu Leu Leu 
            500                 505                 510         


Ala Trp Arg Glu Met Glu Gln Ala Val Glu Leu Cys Gly Arg Glu Asn 
        515                 520                 525             


Glu Val Lys Leu Leu Val Glu Arg Met Met Ala Leu Gln Thr Asp Ile 
    530                 535                 540                 


Val Asp Leu Gln Arg Ser Pro Met Gly Arg Lys Gln Gly Gly Thr Leu 
545                 550                 555                 560 


Asp Asp Leu Glu Glu Gln Ala Arg Glu Leu Tyr Arg Arg Leu Arg Glu 
                565                 570                 575     


Lys Pro Arg Asp Gln Arg Thr Glu Gly Asp Ser Gln Glu Met Val Arg 
            580                 585                 590         


Leu Leu Leu Gln Ala Ile Gln Ser Phe Glu Lys Lys Val Arg Val Ile 
        595                 600                 605             


Tyr Thr Gln Leu Ser Lys Thr Val Val Cys Lys Gln Lys Ala Leu Glu 
    610                 615                 620                 


Leu Leu Pro Lys Val Glu Glu Val Val Ser Leu Met Asn Glu Asp Glu 
625                 630                 635                 640 


Lys Thr Val Val Arg Leu Gln Glu Lys Arg Gln Lys Glu Leu Trp Asn 
                645                 650                 655     


Leu Leu Lys Ile Ala Cys Ser Lys Val Arg Gly Pro Val Ser Gly Ser 
            660                 665                 670         


Pro Asp Ser Met Asn Ala Ser Arg Leu Ser Gln Pro Gly Gln Leu Met 
        675                 680                 685             


Ser Gln Pro Ser Thr Ala Ser Asn Ser Leu Pro Glu Pro Ala Lys Lys 
    690                 695                 700                 


Ser Glu Glu Leu Val Ala Glu Ala His Asn Leu Cys Thr Leu Leu Glu 
705                 710                 715                 720 


Asn Ala Ile Gln Asp Thr Val Arg Glu Gln Asp Gln Ser Phe Thr Ala 
                725                 730                 735     


Leu Asp Trp Ser Trp Leu Gln Thr Glu Glu Glu Glu His Ser Cys Leu 
            740                 745                 750         


Glu Gln Ala Ser 
        755     


<210>  733
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  733

Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210>  734
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  735
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  735

Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile 
1               5                   10                  15      


Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His 
            20                  25                  30          


Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly 
        35                  40                  45              


Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn 
    50                  55                  60                  


Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys 
65                  70                  75                  80  


Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys 
                85                  90                  95      


Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala 
            100                 105                 110         


Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His 
        115                 120                 125             


Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser 
    130                 135                 140                 


Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg 
145                 150                 155                 160 


Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys 
                165                 170                 175     


His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro 
            180                 185                 190         


Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro 
        195                 200                 205             


Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro 
    210                 215                 220                 


Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu 
225                 230                 235                 240 


Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu 
                245                 250                 255     


Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln 
            260                 265                 270         


Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser 
        275                 280                 285             


Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu 
    290                 295                 300                 


Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly 
305                 310                 315                 320 


Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser 
                325                 330                 335     


Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu 
            340                 345                 350         


Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp 
        355                 360                 365             


Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu 
    370                 375                 380                 


Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp 
385                 390                 395                 400 


Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His 
                405                 410                 415     


Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp 
            420                 425                 430         


Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu 
        435                 440                 445             


Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile 
    450                 455                 460                 


Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile 
465                 470                 475                 480 


Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys 
                485                 490                 495     


Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala 
            500                 505                 510         


Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu 
        515                 520                 525             


Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly 
    530                 535                 540                 


Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu 
545                 550                 555                 560 


Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr 
                565                 570                 575     


Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln 
            580                 585                 590         


Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp 
        595                 600                 605             


Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu 
    610                 615                 620                 


Thr Thr Ala Ala Gly Asp Ser 
625                 630     


<210>  736
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  736

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  737
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  737

Met Arg Gly Gly Arg Gly Ala Pro Phe Trp Leu Trp Pro Leu Pro Lys 
1               5                   10                  15      


Leu Ala Leu Leu Pro Leu Leu Trp Val Leu Phe Gln Arg Thr Arg Pro 
            20                  25                  30          


Gln Gly Ser Ala Gly Pro Leu Gln Cys Tyr Gly Val Gly Pro Leu Gly 
        35                  40                  45              


Asp Leu Asn Cys Ser Trp Glu Pro Leu Gly Asp Leu Gly Ala Pro Ser 
    50                  55                  60                  


Glu Leu His Leu Gln Ser Gln Lys Tyr Arg Ser Asn Lys Thr Gln Thr 
65                  70                  75                  80  


Val Ala Val Ala Ala Gly Arg Ser Trp Val Ala Ile Pro Arg Glu Gln 
                85                  90                  95      


Leu Thr Met Ser Asp Lys Leu Leu Val Trp Gly Thr Lys Ala Gly Gln 
            100                 105                 110         


Pro Leu Trp Pro Pro Val Phe Val Asn Leu Glu Thr Gln Met Lys Pro 
        115                 120                 125             


Asn Ala Pro Arg Leu Gly Pro Asp Val Asp Phe Ser Glu Asp Asp Pro 
    130                 135                 140                 


Leu Glu Ala Thr Val His Trp Ala Pro Pro Thr Trp Pro Ser His Lys 
145                 150                 155                 160 


Val Leu Ile Cys Gln Phe His Tyr Arg Arg Cys Gln Glu Ala Ala Trp 
                165                 170                 175     


Thr Leu Leu Glu Pro Glu Leu Lys Thr Ile Pro Leu Thr Pro Val Glu 
            180                 185                 190         


Ile Gln Asp Leu Glu Leu Ala Thr Gly Tyr Lys Val Tyr Gly Arg Cys 
        195                 200                 205             


Arg Met Glu Lys Glu Glu Asp Leu Trp Gly Glu Trp Ser Pro Ile Leu 
    210                 215                 220                 


Ser Phe Gln Thr Pro Pro Ser Ala Pro Lys Asp Val Trp Val Ser Gly 
225                 230                 235                 240 


Asn Leu Cys Gly Thr Pro Gly Gly Glu Glu Pro Leu Leu Leu Trp Lys 
                245                 250                 255     


Ala Pro Gly Pro Cys Val Gln Val Ser Tyr Lys Val Trp Phe Trp Val 
            260                 265                 270         


Gly Gly Arg Glu Leu Ser Pro Glu Gly Ile Thr Cys Cys Cys Ser Leu 
        275                 280                 285             


Ile Pro Ser Gly Ala Glu Trp Ala Arg Val Ser Ala Val Asn Ala Thr 
    290                 295                 300                 


Ser Trp Glu Pro Leu Thr Asn Leu Ser Leu Val Cys Leu Asp Ser Ala 
305                 310                 315                 320 


Ser Ala Pro Arg Ser Val Ala Val Ser Ser Ile Ala Gly Ser Thr Glu 
                325                 330                 335     


Leu Leu Val Thr Trp Gln Pro Gly Pro Gly Glu Pro Leu Glu His Val 
            340                 345                 350         


Val Asp Trp Ala Arg Asp Gly Asp Pro Leu Glu Lys Leu Asn Trp Val 
        355                 360                 365             


Arg Leu Pro Pro Gly Asn Leu Ser Ala Leu Leu Pro Gly Asn Phe Thr 
    370                 375                 380                 


Val Gly Val Pro Tyr Arg Ile Thr Val Thr Ala Val Ser Ala Ser Gly 
385                 390                 395                 400 


Leu Ala Ser Ala Ser Ser Val Trp Gly Phe Arg Glu Glu Leu Ala Pro 
                405                 410                 415     


Leu Val Gly Pro Thr Leu Trp Arg Leu Gln Asp Ala Pro Pro Gly Thr 
            420                 425                 430         


Pro Ala Ile Ala Trp Gly Glu Val Pro Arg His Gln Leu Arg Gly His 
        435                 440                 445             


Leu Thr His Tyr Thr Leu Cys Ala Gln Ser Gly Thr Ser Pro Ser Val 
    450                 455                 460                 


Cys Met Asn Val Ser Gly Asn Thr Gln Ser Val Thr Leu Pro Asp Leu 
465                 470                 475                 480 


Pro Trp Gly Pro Cys Glu Leu Trp Val Thr Ala Ser Thr Ile Ala Gly 
                485                 490                 495     


Gln Gly Pro Pro Gly Pro Ile Leu Arg Leu His Leu Pro Asp Asn Thr 
            500                 505                 510         


Leu Arg Trp Lys Val Leu Pro Gly Ile Leu Phe Leu Trp Gly Leu Phe 
        515                 520                 525             


Leu Leu Gly Cys Gly Leu Ser Leu Ala Thr Ser Gly Arg Cys Tyr His 
    530                 535                 540                 


Leu Arg His Lys Val Leu Pro Arg Trp Val Trp Glu Lys Val Pro Asp 
545                 550                 555                 560 


Pro Ala Asn Ser Ser Ser Gly Gln Pro His Met Glu Gln Val Pro Glu 
                565                 570                 575     


Ala Gln Pro Leu Gly Asp Leu Pro Ile Leu Glu Val Glu Glu Met Glu 
            580                 585                 590         


Pro Pro Pro Val Met Glu Ser Ser Gln Pro Ala Gln Ala Thr Ala Pro 
        595                 600                 605             


Leu Asp Ser Gly Tyr Glu Lys His Phe Leu Pro Thr Pro Glu Glu Leu 
    610                 615                 620                 


Gly Leu Leu Gly Pro Pro Arg Pro Gln Val Leu Ala 
625                 630                 635     


<210>  738
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  739
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  739

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  740
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  741
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro Arg 
        115                 120                 125             


Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro Phe 
    130                 135                 140                 


Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu Ser 
145                 150                 155                 160 


Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu Pro 
                165                 170                 175     


Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu Ala 
            180                 185                 190         


Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His Leu 
        195                 200                 205             


Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val Ile 
    210                 215                 220                 


Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln Gln 
225                 230                 235                 240 


Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala Asn 
                245                 250                 255     


Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu Ser 
            260                 265                 270         


Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu Ser 
        275                 280                 285             


Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys Ala 
    290                 295                 300                 


Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val Glu 
305                 310                 315                 320 


Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp Lys 
                325                 330                 335     


Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys Phe 
            340                 345                 350         


Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile Leu 
        355                 360                 365             


Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe Cys 
    370                 375                 380                 


Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro 
385                 390                 395                 400 


Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala Pro 
                405                 410                 415     


Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly Lys 
            420                 425                 430         


Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val Ile 
        435                 440                 445             


Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile Leu 
    450                 455                 460                 


Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val Ala 
465                 470                 475                 480 


Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro Glu 
                485                 490                 495     


His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr Gly 
            500                 505                 510         


Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe Met 
        515                 520                 525             


Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser Gly 
    530                 535                 540                 


Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu Arg 
545                 550                 555                 560 


Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr His 
                565                 570                 575     


Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val Asp 
            580                 585                 590         


Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln Gln 
        595                 600                 605             


Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg Arg 
    610                 615                 620                 


Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe Ala 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr Thr 
                645                 650                 655     


Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys Asp 
            660                 665                 670         


Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln Ser 
        675                 680                 685             


Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val Phe 
    690                 695                 700                 


Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn Gly 
705                 710                 715                 720 


Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys Tyr 
                725                 730                 735     


Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe His 
            740                 745                 750         


Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn Glu 
        755                 760                 765             


Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu Pro 
    770                 775                 780                 


Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln His 
785                 790                 795                 800 


Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly Glu 
                805                 810                 815     


Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro Ile 
            820                 825                 830         


Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln Gly 
        835                 840                 845             


Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu Tyr 
    850                 855                 860                 


Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr Leu 
865                 870                 875                 880 


Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr Ser 
                885                 890                 895     


Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn Pro 
            900                 905                 910         


Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His Val 
        915                 920                 925             


Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr Asp 
    930                 935                 940                 


Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser Pro 
945                 950                 955                 960 


Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu Pro 
                965                 970                 975     


Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg Pro 
            980                 985                 990         


Ser Asp Leu Gly Lys Asn Ala Gly  Asp Thr Leu Pro Gln  Glu Asp Leu 
        995                 1000                 1005             


Pro Leu  Thr Lys Pro Glu Met  Phe Glu Asn Pro Leu  Tyr Gly Ser 
    1010                 1015                 1020             


Leu Ser  Ser Phe Pro Lys Pro  Ala Pro Arg Lys Asp  Gln Glu Ser 
    1025                 1030                 1035             


Pro Lys  Met Pro Arg Lys Glu  Pro Pro Pro Cys Pro  Glu Pro Gly 
    1040                 1045                 1050             


Ile Leu  Ser Pro Ser Ile Val  Leu Thr Lys Ala Gln  Glu Ala Asp 
    1055                 1060                 1065             


Arg Gly  Glu Gly Pro Gly Lys  Gln Val Pro Ala Pro  Arg Leu Arg 
    1070                 1075                 1080             


Ser Phe  Thr Cys Ser Ser Ser  Ala Glu Gly Arg Ala  Ala Gly Gly 
    1085                 1090                 1095             


Asp Lys  Ser Gln Gly Lys Pro  Lys Thr Pro Val Ser  Ser Gln Ala 
    1100                 1105                 1110             


Pro Val  Pro Ala Lys Arg Pro  Ile Lys Pro Ser Arg  Ser Glu Ile 
    1115                 1120                 1125             


Asn Gln  Gln Thr Pro Pro Thr  Pro Thr Pro Arg Pro  Pro Leu Pro 
    1130                 1135                 1140             


Val Lys  Ser Pro Ala Val Leu  His Leu Gln His Ser  Lys Gly Arg 
    1145                 1150                 1155             


Asp Tyr  Arg Asp Asn Thr Glu  Leu Pro His His Gly  Lys His Arg 
    1160                 1165                 1170             


Pro Glu  Glu Gly Pro Pro Gly  Pro Leu Gly Arg Thr  Ala Met Gln 
    1175                 1180                 1185             


<210>  742
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  742

Met Trp Cys Leu His Cys Asn Ser Glu Arg Thr Gln Ser Leu Leu Glu 
1               5                   10                  15      


Leu Glu Leu Asp Ser Gly Val Glu Gly Glu Ala Pro Ser Ser Glu Thr 
            20                  25                  30          


Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro Leu Val 
        35                  40                  45              


Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser Val Gly 
    50                  55                  60                  


Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg Thr Arg 
65                  70                  75                  80  


Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln Ala Glu 
                85                  90                  95      


Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr Glu Leu 
            100                 105                 110         


Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg Lys Tyr 
        115                 120                 125             


Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln Thr Ala 
    130                 135                 140                 


Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg Ser Ser 
145                 150                 155                 160 


Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn Met Arg 
                165                 170                 175     


Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser Tyr Phe 
            180                 185                 190         


Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu Gly Ala 
        195                 200                 205             


Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr Leu Lys 
    210                 215                 220                 


Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Asp 
                245                 250                 255     


Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala Leu Asp 
            260                 265                 270         


Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His Gly Met 
        275                 280                 285             


Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp Val Thr 
    290                 295                 300                 


Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu Ser Gln 
305                 310                 315                 320 


Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu Arg Ala 
                325                 330                 335     


Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu Asp Lys 
            340                 345                 350         


Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu Arg Gln 
        355                 360                 365             


Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile Glu Pro 
    370                 375                 380                 


Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg Gly Ser 
385                 390                 395                 400 


Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln Gln Gly 
                405                 410                 415     


Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu Pro Arg 
            420                 425                 430         


Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp Ser His 
        435                 440                 445             


Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu Ser Asp 
    450                 455                 460                 


Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn Ser Asn 
465                 470                 475                 480 


Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser Leu Arg 
                485                 490                 495     


Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg Asn Ser 
            500                 505                 510         


Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg His Tyr 
        515                 520                 525             


Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly Val Gln 
    530                 535                 540                 


Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly Val Ala 
545                 550                 555                 560 


His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly Glu 
                565                 570                 575     


Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu Asp Cys 
            580                 585                 590         


Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu Ala Leu 
        595                 600                 605             


Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys Val 
    610                 615                 620                 


Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys Asn Pro 
625                 630                 635                 640 


Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile Leu Ala 
                645                 650                 655     


Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Val Lys 
            660                 665                 670         


Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu Arg Gly 
        675                 680                 685             


Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly Ile Tyr 
    690                 695                 700                 


Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His Val Ser 
705                 710                 715                 720 


Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro Ile Gly 
                725                 730                 735     


Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His Arg Arg 
            740                 745                 750         


Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn Lys Pro 
        755                 760                 765             


Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn Asp Leu 
    770                 775                 780                 


Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val Thr Tyr 
785                 790                 795                 800 


Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu Leu Phe 
                805                 810                 815     


Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser Val Pro 
            820                 825                 830         


Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn Pro Gln 
        835                 840                 845             


Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala Glu Val 
    850                 855                 860                 


Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys Gln Lys 
865                 870                 875                 880 


Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys Lys Glu 
                885                 890                 895     


Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser Tyr Ala 
            900                 905                 910         


Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu Arg Asp 
        915                 920                 925             


Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly Ser Leu 
    930                 935                 940                 


Glu Ser Asn Val Glu Phe Gln Pro Phe Glu Pro Leu Gln Pro Ser Val 
945                 950                 955                 960 


Leu Cys Ser 
            


<210>  743
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  743

Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210>  744
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  744

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  745
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  745

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  746
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Ala Val Tyr Cys Tyr Ala Leu Asn Ser Leu Val Ile Met Asn Ser 
1               5                   10                  15      


Ala Asn Glu Met Lys Ser Gly Gly Gly Pro Gly Pro Ser Gly Ser Glu 
            20                  25                  30          


Thr Pro Pro Pro Pro Arg Arg Ala Val Leu Ser Pro Gly Ser Val Phe 
        35                  40                  45              


Ser Pro Gly Arg Gly Ala Ser Phe Leu Phe Pro Pro Ala Glu Ser Leu 
    50                  55                  60                  


Ser Pro Glu Glu Pro Arg Ser Pro Gly Gly Trp Arg Ser Gly Arg Arg 
65                  70                  75                  80  


Arg Leu Asn Ser Ser Ser Gly Ser Gly Ser Gly Ser Ser Gly Ser Ser 
                85                  90                  95      


Val Ser Ser Pro Ser Trp Ala Gly Arg Leu Arg Gly Asp Arg Gln Gln 
            100                 105                 110         


Val Val Ala Ala Gly Thr Leu Ser Pro Pro Gly Pro Glu Glu Ala Lys 
        115                 120                 125             


Arg Lys Leu Arg Ile Leu Gln Arg Glu Leu Gln Asn Val Gln Val Asn 
    130                 135                 140                 


Gln Lys Val Gly Met Phe Glu Ala His Ile Gln Ala Gln Ser Ser Ala 
145                 150                 155                 160 


Ile Gln Ala Pro Arg Ser Pro Arg Leu Gly Arg Ala Arg Ser Pro Ser 
                165                 170                 175     


Pro Cys Pro Phe Arg Ser Ser Ser Gln Pro Pro Gly Arg Val Leu Val 
            180                 185                 190         


Gln Gly Ala Arg Ser Glu Glu Arg Arg Thr Lys Ser Trp Gly Glu Gln 
        195                 200                 205             


Cys Pro Glu Thr Ser Gly Thr Asp Ser Gly Arg Lys Gly Gly Pro Ser 
    210                 215                 220                 


Leu Cys Ser Ser Gln Val Lys Lys Gly Met Pro Pro Leu Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Pro Thr Gly Ser Glu Ala Gln Gly Pro Ser Ala Phe Val Arg 
                245                 250                 255     


Met Glu Lys Gly Ile Pro Ala Ser Pro Arg Cys Gly Ser Pro Thr Ala 
            260                 265                 270         


Met Glu Ile Asp Lys Arg Gly Ser Pro Thr Pro Gly Thr Arg Ser Cys 
        275                 280                 285             


Leu Ala Pro Ser Leu Gly Leu Phe Gly Ala Ser Leu Thr Met Ala Thr 
    290                 295                 300                 


Glu Val Ala Ala Arg Val Thr Ser Thr Gly Pro His Arg Pro Gln Asp 
305                 310                 315                 320 


Leu Ala Leu Thr Glu Pro Ser Gly Arg Ala Arg Glu Leu Glu Asp Leu 
                325                 330                 335     


Gln Pro Pro Glu Ala Leu Val Glu Arg Gln Gly Gln Phe Leu Gly Ser 
            340                 345                 350         


Glu Thr Ser Pro Ala Pro Glu Arg Gly Gly Pro Arg Asp Gly Glu Pro 
        355                 360                 365             


Pro Gly Lys Met Gly Lys Gly Tyr Leu Pro Cys Gly Met Pro Gly Ser 
    370                 375                 380                 


Gly Glu Pro Glu Val Gly Lys Arg Pro Glu Glu Thr Thr Val Ser Val 
385                 390                 395                 400 


Gln Ser Ala Glu Ser Ser Asp Ser Leu Ser Trp Ser Arg Leu Pro Arg 
                405                 410                 415     


Ala Leu Ala Ser Val Gly Pro Glu Glu Ala Arg Ser Gly Ala Pro Val 
            420                 425                 430         


Gly Gly Gly Arg Trp Gln Leu Ser Asp Arg Val Glu Gly Gly Ser Pro 
        435                 440                 445             


Thr Leu Gly Leu Leu Gly Gly Ser Pro Ser Ala Gln Pro Gly Thr Gly 
    450                 455                 460                 


Asn Val Glu Ala Gly Ile Pro Ser Gly Arg Met Leu Glu Pro Leu Pro 
465                 470                 475                 480 


Cys Trp Asp Ala Ala Lys Asp Leu Lys Glu Pro Gln Cys Pro Pro Gly 
                485                 490                 495     


Asp Arg Val Gly Val Gln Pro Gly Asn Ser Arg Val Trp Gln Gly Thr 
            500                 505                 510         


Met Glu Lys Ala Gly Leu Ala Trp Thr Arg Gly Thr Gly Val Gln Ser 
        515                 520                 525             


Glu Gly Thr Trp Glu Ser Gln Arg Gln Asp Ser Asp Ala Leu Pro Ser 
    530                 535                 540                 


Pro Glu Leu Leu Pro Gln Asp Pro Asp Lys Pro Phe Leu Arg Lys Ala 
545                 550                 555                 560 


Cys Ser Pro Ser Asn Ile Pro Ala Val Ile Ile Thr Asp Met Gly Thr 
                565                 570                 575     


Gln Glu Asp Gly Ala Leu Glu Glu Thr Gln Gly Ser Pro Arg Gly Asn 
            580                 585                 590         


Leu Pro Leu Arg Lys Leu Ser Ser Ser Ser Ala Ser Ser Thr Gly Phe 
        595                 600                 605             


Ser Ser Ser Tyr Glu Asp Ser Glu Glu Asp Ile Ser Ser Asp Pro Glu 
    610                 615                 620                 


Arg Thr Leu Asp Pro Asn Ser Ala Phe Leu His Thr Leu Asp Gln Gln 
625                 630                 635                 640 


Lys Pro Arg Val Ser Lys Ser Trp Arg Lys Ile Lys Asn Met Val His 
                645                 650                 655     


Trp Ser Pro Phe Val Met Ser Phe Lys Lys Lys Tyr Pro Trp Ile Gln 
            660                 665                 670         


Leu Ala Gly His Ala Gly Ser Phe Lys Ala Ala Ala Asn Gly Arg Ile 
        675                 680                 685             


Leu Lys Lys His Cys Glu Ser Glu Gln Arg Cys Leu Asp Arg Leu Met 
    690                 695                 700                 


Val Asp Val Leu Arg Pro Phe Val Pro Ala Tyr His Gly Asp Val Val 
705                 710                 715                 720 


Lys Asp Gly Glu Arg Tyr Asn Gln Met Asp Asp Leu Leu Ala Asp Phe 
                725                 730                 735     


Asp Ser Pro Cys Val Met Asp Cys Lys Met Gly Ile Arg Thr Tyr Leu 
            740                 745                 750         


Glu Glu Glu Leu Thr Lys Ala Arg Lys Lys Pro Ser Leu Arg Lys Asp 
        755                 760                 765             


Met Tyr Gln Lys Met Ile Glu Val Asp Pro Glu Ala Pro Thr Glu Glu 
    770                 775                 780                 


Glu Lys Ala Gln Arg Ala Val Thr Lys Pro Arg Tyr Met Gln Trp Arg 
785                 790                 795                 800 


Glu Thr Ile Ser Ser Thr Ala Thr Leu Gly Phe Arg Ile Glu Gly Ile 
                805                 810                 815     


Lys Lys Glu Asp Gly Thr Val Asn Arg Asp Phe Lys Lys Thr Lys Thr 
            820                 825                 830         


Arg Glu Gln Val Thr Glu Ala Phe Arg Glu Phe Thr Lys Gly Asn His 
        835                 840                 845             


Asn Ile Leu Ile Ala Tyr Arg Asp Arg Leu Lys Ala Ile Arg Thr Thr 
    850                 855                 860                 


Leu Glu Val Ser Pro Phe Phe Lys Cys His Glu Val Ile Gly Ser Ser 
865                 870                 875                 880 


Leu Leu Phe Ile His Asp Lys Lys Glu Gln Ala Lys Val Trp Met Ile 
                885                 890                 895     


Asp Phe Gly Lys Thr Thr Pro Leu Pro Glu Gly Gln Thr Leu Gln His 
            900                 905                 910         


Asp Val Pro Trp Gln Glu Gly Asn Arg Glu Asp Gly Tyr Leu Ser Gly 
        915                 920                 925             


Leu Asn Asn Leu Val Asp Ile Leu Thr Glu Met Ser Gln Asp Ala Pro 
    930                 935                 940                 


Leu Ala 
945     


<210>  747
<211>  1697
<212>  PRT
<213>  Homo sapiens

<400>  747

Met Met Ala Gln Phe Pro Thr Ala Met Asn Gly Gly Pro Asn Met Trp 
1               5                   10                  15      


Ala Ile Thr Ser Glu Glu Arg Thr Lys His Asp Arg Gln Phe Asp Asn 
            20                  25                  30          


Leu Lys Pro Ser Gly Gly Tyr Ile Thr Gly Asp Gln Ala Arg Asn Phe 
        35                  40                  45              


Phe Leu Gln Ser Gly Leu Pro Ala Pro Val Leu Ala Glu Ile Trp Ala 
    50                  55                  60                  


Leu Ser Asp Leu Asn Lys Asp Gly Lys Met Asp Gln Gln Glu Phe Ser 
65                  70                  75                  80  


Ile Ala Met Lys Leu Ile Lys Leu Lys Leu Gln Gly Gln Gln Leu Pro 
                85                  90                  95      


Val Val Leu Pro Pro Ile Met Lys Gln Pro Pro Met Phe Ser Pro Leu 
            100                 105                 110         


Ile Ser Ala Arg Phe Gly Met Gly Ser Met Pro Asn Leu Ser Ile Pro 
        115                 120                 125             


Gln Pro Leu Pro Pro Ala Ala Pro Ile Thr Ser Leu Ser Ser Ala Thr 
    130                 135                 140                 


Ser Gly Thr Asn Leu Pro Pro Leu Met Met Pro Thr Pro Leu Val Pro 
145                 150                 155                 160 


Ser Val Ser Thr Ser Ser Leu Pro Asn Gly Thr Ala Ser Leu Ile Gln 
                165                 170                 175     


Pro Leu Pro Ile Pro Tyr Ser Ser Ser Thr Leu Pro His Gly Ser Ser 
            180                 185                 190         


Tyr Ser Leu Met Met Gly Gly Phe Gly Gly Ala Ser Ile Gln Lys Ala 
        195                 200                 205             


Gln Ser Leu Ile Asp Leu Gly Ser Ser Ser Ser Thr Ser Ser Thr Ala 
    210                 215                 220                 


Ser Leu Ser Gly Asn Ser Pro Lys Thr Gly Thr Ser Glu Trp Ala Val 
225                 230                 235                 240 


Pro Gln Pro Thr Arg Leu Lys Tyr Arg Gln Lys Phe Asn Thr Leu Asp 
                245                 250                 255     


Lys Ser Met Ser Gly Tyr Leu Ser Gly Phe Gln Ala Arg Asn Ala Leu 
            260                 265                 270         


Leu Gln Ser Asn Leu Ser Gln Thr Gln Leu Ala Thr Ile Trp Thr Leu 
        275                 280                 285             


Ala Asp Val Asp Gly Asp Gly Gln Leu Lys Ala Glu Glu Phe Ile Leu 
    290                 295                 300                 


Ala Met His Leu Thr Asp Met Ala Lys Ala Gly Gln Pro Leu Pro Leu 
305                 310                 315                 320 


Thr Leu Pro Pro Glu Leu Val Pro Pro Ser Phe Arg Gly Gly Lys Gln 
                325                 330                 335     


Ile Asp Ser Ile Asn Gly Thr Leu Pro Ser Tyr Gln Lys Met Gln Glu 
            340                 345                 350         


Glu Glu Pro Gln Lys Lys Leu Pro Val Thr Phe Glu Asp Lys Arg Lys 
        355                 360                 365             


Ala Asn Tyr Glu Arg Gly Asn Met Glu Leu Glu Lys Arg Arg Gln Ala 
    370                 375                 380                 


Leu Met Glu Gln Gln Gln Arg Glu Ala Glu Arg Lys Ala Gln Lys Glu 
385                 390                 395                 400 


Lys Glu Glu Trp Glu Arg Lys Gln Arg Glu Leu Gln Glu Gln Glu Trp 
                405                 410                 415     


Lys Lys Gln Leu Glu Leu Glu Lys Arg Leu Glu Lys Gln Arg Glu Leu 
            420                 425                 430         


Glu Arg Gln Arg Glu Glu Glu Arg Arg Lys Asp Ile Glu Arg Arg Glu 
        435                 440                 445             


Ala Ala Lys Gln Glu Leu Glu Arg Gln Arg Arg Leu Glu Trp Glu Arg 
    450                 455                 460                 


Ile Arg Arg Gln Glu Leu Leu Asn Gln Lys Asn Arg Glu Gln Glu Glu 
465                 470                 475                 480 


Ile Val Arg Leu Asn Ser Lys Lys Lys Asn Leu His Leu Glu Leu Glu 
                485                 490                 495     


Ala Leu Asn Gly Lys His Gln Gln Ile Ser Gly Arg Leu Gln Asp Val 
            500                 505                 510         


Arg Leu Lys Lys Gln Thr Gln Lys Thr Glu Leu Glu Val Leu Asp Lys 
        515                 520                 525             


Gln Cys Asp Leu Glu Ile Met Glu Ile Lys Gln Leu Gln Gln Glu Leu 
    530                 535                 540                 


Gln Glu Tyr Gln Asn Lys Leu Ile Tyr Leu Val Pro Glu Lys Gln Leu 
545                 550                 555                 560 


Leu Asn Glu Arg Ile Lys Asn Met Gln Phe Ser Asn Thr Pro Asp Ser 
                565                 570                 575     


Gly Val Ser Leu Leu His Lys Lys Ser Leu Glu Lys Glu Glu Leu Cys 
            580                 585                 590         


Gln Arg Leu Lys Glu Gln Leu Asp Ala Leu Glu Lys Glu Thr Ala Ser 
        595                 600                 605             


Lys Leu Ser Glu Met Asp Ser Phe Asn Asn Gln Leu Lys Cys Gly Asn 
    610                 615                 620                 


Met Asp Asp Ser Val Leu Gln Cys Leu Leu Ser Leu Leu Ser Cys Leu 
625                 630                 635                 640 


Asn Asn Leu Phe Leu Leu Leu Lys Glu Leu Arg Glu Thr Tyr Asn Thr 
                645                 650                 655     


Gln Gln Leu Ala Leu Glu Gln Leu Tyr Lys Ile Lys Arg Asp Lys Leu 
            660                 665                 670         


Lys Glu Ile Glu Arg Lys Arg Leu Glu Leu Met Gln Lys Lys Lys Leu 
        675                 680                 685             


Glu Asp Glu Ala Ala Arg Lys Ala Lys Gln Gly Lys Glu Asn Leu Trp 
    690                 695                 700                 


Lys Glu Asn Leu Arg Lys Glu Glu Glu Glu Lys Gln Lys Arg Leu Gln 
705                 710                 715                 720 


Glu Glu Lys Thr Gln Glu Lys Ile Gln Glu Glu Glu Arg Lys Ala Glu 
                725                 730                 735     


Glu Lys Gln Arg Lys Asp Lys Asp Thr Leu Lys Ala Glu Glu Lys Lys 
            740                 745                 750         


Arg Glu Thr Ala Ser Val Leu Val Asn Tyr Arg Ala Leu Tyr Pro Phe 
        755                 760                 765             


Glu Ala Arg Asn His Asp Glu Met Ser Phe Asn Ser Gly Asp Ile Ile 
    770                 775                 780                 


Gln Val Asp Glu Lys Thr Val Gly Glu Pro Gly Trp Leu Tyr Gly Ser 
785                 790                 795                 800 


Phe Gln Gly Asn Phe Gly Trp Phe Pro Cys Asn Tyr Val Glu Lys Met 
                805                 810                 815     


Pro Ser Ser Glu Asn Glu Lys Ala Val Ser Pro Lys Lys Ala Leu Leu 
            820                 825                 830         


Pro Pro Thr Val Ser Leu Ser Ala Thr Ser Thr Ser Ser Glu Pro Leu 
        835                 840                 845             


Ser Ser Asn Gln Pro Ala Ser Val Thr Asp Tyr Gln Asn Val Ser Phe 
    850                 855                 860                 


Ser Asn Leu Thr Val Asn Thr Ser Trp Gln Lys Lys Ser Ala Phe Thr 
865                 870                 875                 880 


Arg Thr Val Ser Pro Gly Ser Val Ser Pro Ile His Gly Gln Gly Gln 
                885                 890                 895     


Val Val Glu Asn Leu Lys Ala Gln Ala Leu Cys Ser Trp Thr Ala Lys 
            900                 905                 910         


Lys Asp Asn His Leu Asn Phe Ser Lys His Asp Ile Ile Thr Val Leu 
        915                 920                 925             


Glu Gln Gln Glu Asn Trp Trp Phe Gly Glu Val His Gly Gly Arg Gly 
    930                 935                 940                 


Trp Phe Pro Lys Ser Tyr Val Lys Ile Ile Pro Gly Ser Glu Val Lys 
945                 950                 955                 960 


Arg Glu Glu Pro Glu Ala Leu Tyr Ala Ala Val Asn Lys Lys Pro Thr 
                965                 970                 975     


Ser Ala Ala Tyr Ser Val Gly Glu Glu Tyr Ile Ala Leu Tyr Pro Tyr 
            980                 985                 990         


Ser Ser Val Glu Pro Gly Asp Leu  Thr Phe Thr Glu Gly  Glu Glu Ile 
        995                 1000                 1005             


Leu Val  Thr Gln Lys Asp Gly  Glu Trp Trp Thr Gly  Ser Ile Gly 
    1010                 1015                 1020             


Asp Arg  Ser Gly Ile Phe Pro  Ser Asn Tyr Val Lys  Pro Lys Asp 
    1025                 1030                 1035             


Gln Glu  Ser Phe Gly Ser Ala  Ser Lys Ser Gly Ala  Ser Asn Lys 
    1040                 1045                 1050             


Lys Pro  Glu Ile Ala Gln Val  Thr Ser Ala Tyr Val  Ala Ser Gly 
    1055                 1060                 1065             


Ser Glu  Gln Leu Ser Leu Ala  Pro Gly Gln Leu Ile  Leu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Asn Thr Ser Gly Trp  Trp Gln Gly Glu Leu  Gln Ala Arg 
    1085                 1090                 1095             


Gly Lys  Lys Arg Gln Lys Gly  Trp Phe Pro Ala Ser  His Val Lys 
    1100                 1105                 1110             


Leu Leu  Gly Pro Ser Ser Glu  Arg Ala Thr Pro Ala  Phe His Pro 
    1115                 1120                 1125             


Val Cys  Gln Val Ile Ala Met  Tyr Asp Tyr Ala Ala  Asn Asn Glu 
    1130                 1135                 1140             


Asp Glu  Leu Ser Phe Ser Lys  Gly Gln Leu Ile Asn  Val Met Asn 
    1145                 1150                 1155             


Lys Asp  Asp Pro Asp Trp Trp  Gln Gly Glu Ile Asn  Gly Val Thr 
    1160                 1165                 1170             


Gly Leu  Phe Pro Ser Asn Tyr  Val Lys Met Thr Thr  Asp Ser Asp 
    1175                 1180                 1185             


Pro Ser  Gln Gln Trp Cys Ala  Asp Leu Gln Thr Leu  Asp Thr Met 
    1190                 1195                 1200             


Gln Pro  Ile Glu Arg Lys Arg  Gln Gly Tyr Ile His  Glu Leu Ile 
    1205                 1210                 1215             


Gln Thr  Glu Glu Arg Tyr Met  Ala Asp Leu Gln Leu  Val Val Glu 
    1220                 1225                 1230             


Val Phe  Gln Lys Arg Met Ala  Glu Ser Gly Phe Leu  Thr Glu Gly 
    1235                 1240                 1245             


Glu Met  Ala Leu Ile Phe Val  Asn Trp Lys Glu Leu  Ile Met Ser 
    1250                 1255                 1260             


Asn Thr  Lys Leu Leu Lys Ala  Leu Arg Val Arg Lys  Lys Thr Gly 
    1265                 1270                 1275             


Gly Glu  Lys Met Pro Val Gln  Met Ile Gly Asp Ile  Leu Ala Ala 
    1280                 1285                 1290             


Glu Leu  Ser His Met Gln Ala  Tyr Ile Arg Phe Cys  Ser Cys Gln 
    1295                 1300                 1305             


Leu Asn  Gly Ala Ala Leu Leu  Gln Gln Lys Thr Asp  Glu Asp Thr 
    1310                 1315                 1320             


Asp Phe  Lys Glu Phe Leu Lys  Lys Leu Ala Ser Asp  Pro Arg Cys 
    1325                 1330                 1335             


Lys Gly  Met Pro Leu Ser Ser  Phe Leu Leu Lys Pro  Met Gln Arg 
    1340                 1345                 1350             


Ile Thr  Arg Tyr Pro Leu Leu  Ile Arg Ser Ile Leu  Glu Asn Thr 
    1355                 1360                 1365             


Pro Glu  Ser His Ala Asp His  Ser Ser Leu Lys Leu  Ala Leu Glu 
    1370                 1375                 1380             


Arg Ala  Glu Glu Leu Cys Ser  Gln Val Asn Glu Gly  Val Arg Glu 
    1385                 1390                 1395             


Lys Glu  Asn Ser Asp Arg Leu  Glu Trp Ile Gln Ala  His Val Gln 
    1400                 1405                 1410             


Cys Glu  Gly Leu Ala Glu Gln  Leu Ile Phe Asn Ser  Leu Thr Asn 
    1415                 1420                 1425             


Cys Leu  Gly Pro Arg Lys Leu  Leu His Ser Gly Lys  Leu Tyr Lys 
    1430                 1435                 1440             


Thr Lys  Ser Asn Lys Glu Leu  His Gly Phe Leu Phe  Asn Asp Phe 
    1445                 1450                 1455             


Leu Leu  Leu Thr Tyr Met Val  Lys Gln Phe Ala Val  Ser Ser Gly 
    1460                 1465                 1470             


Ser Glu  Lys Leu Phe Ser Ser  Lys Ser Asn Ala Gln  Phe Lys Met 
    1475                 1480                 1485             


Tyr Lys  Thr Pro Ile Phe Leu  Asn Glu Val Leu Val  Lys Leu Pro 
    1490                 1495                 1500             


Thr Asp  Pro Ser Ser Asp Glu  Pro Val Phe His Ile  Ser His Ile 
    1505                 1510                 1515             


Asp Arg  Val Tyr Thr Leu Arg  Thr Asp Asn Ile Asn  Glu Arg Thr 
    1520                 1525                 1530             


Ala Trp  Val Gln Lys Ile Lys  Ala Ala Ser Glu Gln  Tyr Ile Asp 
    1535                 1540                 1545             


Thr Glu  Lys Lys Lys Arg Glu  Lys Ala Tyr Gln Ala  Arg Ser Gln 
    1550                 1555                 1560             


Lys Thr  Ser Gly Ile Gly Arg  Leu Met Val His Val  Ile Glu Ala 
    1565                 1570                 1575             


Thr Glu  Leu Lys Ala Cys Lys  Pro Asn Gly Lys Ser  Asn Pro Tyr 
    1580                 1585                 1590             


Cys Glu  Ile Ser Met Gly Ser  Gln Ser Tyr Thr Thr  Arg Thr Ile 
    1595                 1600                 1605             


Gln Asp  Thr Leu Asn Pro Lys  Trp Asn Phe Asn Cys  Gln Phe Phe 
    1610                 1615                 1620             


Ile Lys  Asp Leu Tyr Gln Asp  Val Leu Cys Leu Thr  Leu Phe Asp 
    1625                 1630                 1635             


Arg Asp  Gln Phe Ser Pro Asp  Asp Phe Leu Gly Arg  Thr Glu Ile 
    1640                 1645                 1650             


Pro Val  Ala Lys Ile Arg Thr  Glu Gln Glu Ser Lys  Gly Pro Met 
    1655                 1660                 1665             


Thr Arg  Arg Leu Leu Leu His  Glu Val Pro Thr Gly  Glu Val Trp 
    1670                 1675                 1680             


Val Arg  Phe Asp Leu Gln Leu  Phe Glu Gln Lys Thr  Leu Leu 
    1685                 1690                 1695         


<210>  748
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  749
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  749

Met Ser Thr Gln Asp Glu Arg Gln Ile Asn Thr Glu Tyr Ala Val Ser 
1               5                   10                  15      


Leu Leu Glu Gln Leu Lys Leu Phe Tyr Glu Gln Gln Leu Phe Thr Asp 
            20                  25                  30          


Ile Val Leu Ile Val Glu Gly Thr Glu Phe Pro Cys His Lys Met Val 
        35                  40                  45              


Leu Ala Thr Cys Ser Ser Tyr Phe Arg Ala Met Phe Met Ser Gly Leu 
    50                  55                  60                  


Ser Glu Ser Lys Gln Thr His Val His Leu Arg Asn Val Asp Ala Ala 
65                  70                  75                  80  


Thr Leu Gln Ile Ile Ile Thr Tyr Ala Tyr Thr Gly Asn Leu Ala Met 
                85                  90                  95      


Asn Asp Ser Thr Val Glu Gln Leu Tyr Glu Thr Ala Cys Phe Leu Gln 
            100                 105                 110         


Val Glu Asp Val Leu Gln Arg Cys Arg Glu Tyr Leu Ile Lys Lys Ile 
        115                 120                 125             


Asn Ala Glu Asn Cys Val Arg Leu Leu Ser Phe Ala Asp Leu Phe Ser 
    130                 135                 140                 


Cys Glu Glu Leu Lys Gln Ser Ala Lys Arg Met Val Glu His Lys Phe 
145                 150                 155                 160 


Thr Ala Val Tyr His Gln Asp Ala Phe Met Gln Leu Ser His Asp Leu 
                165                 170                 175     


Leu Ile Asp Ile Leu Ser Ser Asp Asn Leu Asn Val Glu Lys Glu Glu 
            180                 185                 190         


Thr Val Arg Glu Ala Ala Met Leu Trp Leu Glu Tyr Asn Thr Glu Ser 
        195                 200                 205             


Arg Ser Gln Tyr Leu Ser Ser Val Leu Ser Gln Ile Arg Ile Asp Ala 
    210                 215                 220                 


Leu Ser Glu Val Thr Gln Arg Ala Trp Phe Gln Gly Leu Pro Pro Asn 
225                 230                 235                 240 


Asp Lys Ser Val Val Val Gln Gly Leu Tyr Lys Ser Met Pro Lys Phe 
                245                 250                 255     


Phe Lys Pro Arg Leu Gly Met Thr Lys Glu Glu Met Met Ile Phe Ile 
            260                 265                 270         


Glu Ala Ser Ser Glu Asn Pro Cys Ser Leu Tyr Ser Ser Val Cys Tyr 
        275                 280                 285             


Ser Pro Gln Ala Glu Lys Val Tyr Lys Leu Cys Ser Pro Pro Ala Asp 
    290                 295                 300                 


Leu His Lys Val Gly Thr Val Val Thr Pro Asp Asn Asp Ile Tyr Ile 
305                 310                 315                 320 


Ala Gly Gly Gln Val Pro Leu Lys Asn Thr Lys Thr Asn His Ser Lys 
                325                 330                 335     


Thr Ser Lys Leu Gln Thr Ala Phe Arg Thr Val Asn Cys Phe Tyr Trp 
            340                 345                 350         


Phe Asp Ala Gln Gln Asn Thr Trp Phe Pro Lys Thr Pro Met Leu Phe 
        355                 360                 365             


Val Arg Ile Lys Pro Ser Leu Val Cys Cys Glu Gly Tyr Ile Tyr Ala 
    370                 375                 380                 


Ile Gly Gly Asp Ser Val Gly Gly Glu Leu Asn Arg Arg Thr Val Glu 
385                 390                 395                 400 


Arg Tyr Asp Thr Glu Lys Asp Glu Trp Thr Met Val Ser Pro Leu Pro 
                405                 410                 415     


Cys Ala Trp Gln Trp Ser Ala Ala Val Val Val His Asp Cys Ile Tyr 
            420                 425                 430         


Val Met Thr Leu Asn Leu Met Tyr Cys Tyr Phe Pro Arg Ser Asp Ser 
        435                 440                 445             


Trp Val Glu Met Ala Met Arg Gln Thr Ser Arg Ser Phe Ala Ser Ala 
    450                 455                 460                 


Ala Ala Phe Gly Asp Lys Ile Phe Tyr Ile Gly Gly Leu His Ile Ala 
465                 470                 475                 480 


Thr Asn Ser Gly Ile Arg Leu Pro Ser Gly Thr Val Asp Gly Ser Ser 
                485                 490                 495     


Val Thr Val Glu Ile Tyr Asp Val Asn Lys Asn Glu Trp Lys Met Ala 
            500                 505                 510         


Ala Asn Ile Pro Ala Lys Arg Tyr Ser Asp Pro Cys Val Arg Ala Val 
        515                 520                 525             


Val Ile Ser Asn Ser Leu Cys Val Phe Met Arg Glu Thr His Leu Asn 
    530                 535                 540                 


Glu Arg Ala Lys Tyr Val Thr Tyr Gln Tyr Asp Leu Glu Leu Asp Arg 
545                 550                 555                 560 


Trp Ser Leu Arg Gln His Ile Ser Glu Arg Val Leu Trp Asp Leu Gly 
                565                 570                 575     


Arg Asp Phe Arg Cys Thr Val Gly Lys Leu Tyr Pro Ser Cys Leu Glu 
            580                 585                 590         


Glu Ser Pro Trp Lys Pro Pro Thr Tyr Leu Phe Ser Thr Asp Gly Thr 
        595                 600                 605             


Glu Glu Phe Glu Leu Asp Gly Glu Met Val Ala Leu Pro Pro Val 
    610                 615                 620             


<210>  750
<211>  1395
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Tyr Pro Ile Cys Thr Val Val Val Asp Gly Leu Pro Ser Glu Ser 
1               5                   10                  15      


Ser Ser Ser Ser Tyr Pro Gly Pro Val Ser Val Ser Glu Met Ser Leu 
            20                  25                  30          


Leu His Ala Leu Gly Pro Val Gln Thr Trp Leu Gly Gln Glu Leu Glu 
        35                  40                  45              


Lys Cys Gly Ile Asp Ala Met Ile Tyr Thr Arg Tyr Val Leu Ser Leu 
    50                  55                  60                  


Leu Leu His Asp Ser Tyr Asp Tyr Asp Leu Gln Glu Gln Glu Asn Asp 
65                  70                  75                  80  


Ile Phe Leu Gly Trp Glu Lys Gly Ala Tyr Lys Lys Trp Gly Lys Ser 
                85                  90                  95      


Lys Lys Lys Cys Ser Asp Leu Thr Leu Glu Glu Met Lys Lys Gln Ala 
            100                 105                 110         


Ala Val Gln Cys Leu Arg Ser Ala Ser Asp Glu Ser Ser Gly Ile Glu 
        115                 120                 125             


Thr Leu Val Glu Glu Leu Cys Ser Arg Leu Lys Asp Leu Gln Ser Lys 
    130                 135                 140                 


Gln Glu Glu Lys Ile His Lys Lys Leu Glu Gly Ser Pro Ser Pro Glu 
145                 150                 155                 160 


Ala Glu Leu Ser Pro Pro Ala Lys Asp Gln Val Glu Met Tyr Tyr Glu 
                165                 170                 175     


Ala Phe Pro Pro Leu Ser Glu Lys Pro Val Cys Leu Gln Glu Ile Met 
            180                 185                 190         


Thr Val Trp Asn Lys Ser Lys Val Cys Ser Tyr Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Ala Pro Pro Ala Ser Thr Asp Thr Ser Ser Pro Lys Asp 
    210                 215                 220                 


Cys Asn Ser Glu Ser Glu Val Thr Lys Glu Arg Ser Ser Glu Val Pro 
225                 230                 235                 240 


Thr Thr Val His Glu Lys Thr Gln Ser Lys Ser Lys Asn Glu Lys Glu 
                245                 250                 255     


Asn Lys Phe Ser Asn Gly Thr Ile Glu Glu Lys Pro Ala Leu Tyr Lys 
            260                 265                 270         


Lys Gln Ile Arg His Lys Pro Glu Gly Lys Ile Arg Pro Arg Ser Trp 
        275                 280                 285             


Ser Ser Gly Ser Ser Glu Ala Gly Ser Ser Ser Ser Gly Asn Gln Gly 
    290                 295                 300                 


Glu Leu Lys Ala Ser Met Lys Tyr Val Lys Val Arg His Lys Ala Arg 
305                 310                 315                 320 


Glu Ile Arg Asn Lys Lys Gly Arg Asn Gly Gln Ser Arg Leu Ser Leu 
                325                 330                 335     


Lys His Gly Glu Lys Ala Glu Arg Asn Ile His Thr Gly Ser Ser Ser 
            340                 345                 350         


Ser Ser Ser Ser Gly Ser Val Lys Gln Leu Cys Lys Arg Gly Lys Arg 
        355                 360                 365             


Pro Leu Lys Glu Ile Gly Arg Lys Asp Pro Gly Ser Thr Glu Gly Lys 
    370                 375                 380                 


Asp Leu Tyr Met Glu Asn Arg Lys Asp Thr Glu Tyr Lys Glu Glu Pro 
385                 390                 395                 400 


Leu Trp Tyr Thr Glu Pro Ile Ala Glu Tyr Phe Val Pro Leu Ser Arg 
                405                 410                 415     


Lys Ser Lys Leu Glu Thr Thr Tyr Arg Asn Arg Gln Asp Thr Ser Asp 
            420                 425                 430         


Leu Thr Ser Glu Ala Val Glu Glu Leu Ser Glu Ser Val His Gly Leu 
        435                 440                 445             


Cys Ile Ser Asn Asn Asn Leu His Lys Thr Tyr Leu Ala Ala Gly Thr 
    450                 455                 460                 


Phe Ile Asp Gly His Phe Val Glu Met Pro Ala Val Ile Asn Glu Asp 
465                 470                 475                 480 


Ile Asp Leu Thr Gly Thr Ser Leu Cys Ser Leu Pro Glu Asp Asn Lys 
                485                 490                 495     


Tyr Leu Asp Asp Ile His Leu Ser Glu Leu Thr His Phe Tyr Glu Val 
            500                 505                 510         


Asp Ile Asp Gln Ser Met Leu Asp Pro Gly Ala Ser Glu Thr Met Gln 
        515                 520                 525             


Gly Glu Ser Arg Ile Leu Asn Met Ile Arg Gln Lys Ser Lys Glu Asn 
    530                 535                 540                 


Thr Asp Phe Glu Ala Glu Cys Cys Ile Val Leu Asp Gly Met Glu Leu 
545                 550                 555                 560 


Gln Gly Glu Arg Ala Ile Trp Thr Asp Ser Thr Ser Ser Val Gly Ala 
                565                 570                 575     


Glu Gly Leu Phe Leu Gln Asp Leu Gly Asn Leu Ala Gln Phe Trp Glu 
            580                 585                 590         


Cys Cys Ser Ser Ser Ser Gly Asp Ala Asp Gly Glu Ser Phe Gly Gly 
        595                 600                 605             


Asp Ser Pro Val Arg Leu Ser Pro Ile Leu Asp Ser Thr Val Leu Asn 
    610                 615                 620                 


Ser His Leu Leu Ala Gly Asn Gln Glu Leu Phe Ser Asp Ile Asn Glu 
625                 630                 635                 640 


Gly Ser Gly Ile Asn Ser Cys Phe Ser Val Phe Glu Val Gln Cys Ser 
                645                 650                 655     


Asn Ser Val Leu Pro Phe Ser Phe Glu Thr Leu Asn Leu Gly Asn Glu 
            660                 665                 670         


Asn Thr Asp Ser Ser Ala Asn Met Leu Gly Lys Thr Gln Ser Arg Leu 
        675                 680                 685             


Leu Ile Trp Thr Lys Asn Ser Ala Phe Glu Glu Asn Glu His Cys Ser 
    690                 695                 700                 


Asn Leu Ser Thr Arg Thr Cys Ser Pro Trp Ser His Ser Glu Glu Thr 
705                 710                 715                 720 


Arg Ser Asp Asn Glu Thr Leu Asn Ile Gln Phe Glu Glu Ser Thr Gln 
                725                 730                 735     


Phe Asn Ala Glu Asp Ile Asn Tyr Val Val Pro Arg Val Ser Ser Asn 
            740                 745                 750         


Tyr Val Asp Glu Glu Leu Leu Asp Phe Leu Gln Asp Glu Thr Cys Gln 
        755                 760                 765             


Gln Asn Ser Arg Thr Leu Gly Glu Ile Pro Thr Leu Val Phe Lys Lys 
    770                 775                 780                 


Thr Ser Lys Leu Glu Ser Val Cys Gly Ile Gln Leu Glu Gln Lys Thr 
785                 790                 795                 800 


Glu Asn Lys Asn Phe Glu Thr Thr Gln Val Cys Asn Glu Ser Pro His 
                805                 810                 815     


Gly Asp Gly Tyr Ser Ser Gly Val Ile Lys Asp Ile Trp Thr Lys Met 
            820                 825                 830         


Ala Asp Thr Asn Ser Val Ala Thr Val Glu Ile Glu Arg Thr Asp Ala 
        835                 840                 845             


Glu Leu Phe Ser Ala Asp Val Asn Asn Tyr Cys Cys Cys Leu Asp Ala 
    850                 855                 860                 


Glu Ala Glu Leu Glu Thr Leu Gln Glu Pro Asp Lys Ala Val Arg Arg 
865                 870                 875                 880 


Ser Glu Tyr His Leu Trp Glu Gly Gln Lys Glu Ser Leu Glu Lys Arg 
                885                 890                 895     


Ala Phe Ala Ser Ser Glu Leu Ser Asn Val Asp Gly Gly Asp Tyr Thr 
            900                 905                 910         


Thr Pro Ser Lys Pro Trp Asp Val Ala Gln Asp Lys Glu Asn Thr Phe 
        915                 920                 925             


Ile Leu Gly Gly Val Tyr Gly Glu Leu Lys Thr Phe Asn Ser Asp Gly 
    930                 935                 940                 


Glu Trp Ala Val Val Pro Pro Ser His Thr Lys Gly Ser Leu Leu Gln 
945                 950                 955                 960 


Cys Ala Ala Ser Asp Val Val Thr Ile Ala Gly Thr Asp Val Phe Met 
                965                 970                 975     


Thr Pro Gly Asn Ser Phe Ala Pro Gly His Arg Gln Leu Trp Lys Pro 
            980                 985                 990         


Phe Val Ser Phe Glu Gln Asn Asp  Gln Pro Lys Ser Gly  Glu Asn Gly 
        995                 1000                 1005             


Leu Asn  Lys Gly Phe Ser Phe  Ile Phe His Glu Asp  Leu Leu Gly 
    1010                 1015                 1020             


Ala Cys  Gly Asn Phe Gln Val  Glu Asp Pro Gly Leu  Glu Tyr Ser 
    1025                 1030                 1035             


Phe Ser  Ser Phe Asp Leu Ser  Asn Pro Phe Ser Gln  Val Leu His 
    1040                 1045                 1050             


Val Glu  Cys Ser Phe Glu Pro  Glu Gly Ile Ala Ser  Phe Ser Pro 
    1055                 1060                 1065             


Ser Phe  Lys Pro Lys Ser Ile  Leu Cys Ser Asp Ser  Asp Ser Glu 
    1070                 1075                 1080             


Val Phe  His Pro Arg Ile Cys  Gly Val Asp Arg Thr  Gln Tyr Arg 
    1085                 1090                 1095             


Ala Ile  Arg Ile Ser Pro Arg  Thr His Phe Arg Pro  Ile Ser Ala 
    1100                 1105                 1110             


Ser Glu  Leu Ser Pro Gly Gly  Gly Ser Glu Ser Glu  Phe Glu Ser 
    1115                 1120                 1125             


Glu Lys  Asp Glu Ala Asn Ile  Pro Ile Pro Ser Gln  Val Asp Ile 
    1130                 1135                 1140             


Phe Glu  Asp Pro Gln Ala Asp  Leu Lys Pro Leu Glu  Glu Asp Ala 
    1145                 1150                 1155             


Glu Lys  Glu Gly His Tyr Tyr  Gly Lys Ser Glu Leu  Glu Ser Gly 
    1160                 1165                 1170             


Lys Phe  Leu Pro Arg Leu Lys  Lys Ser Gly Met Glu  Lys Ser Ala 
    1175                 1180                 1185             


Gln Thr  Ser Leu Asp Ser Gln  Glu Glu Ser Thr Gly  Ile Leu Ser 
    1190                 1195                 1200             


Val Gly  Lys Gln Asn Gln Cys  Leu Glu Cys Ser Met  Asn Glu Ser 
    1205                 1210                 1215             


Leu Glu  Ile Asp Leu Glu Ser  Ser Glu Ala Asn Cys  Lys Ile Met 
    1220                 1225                 1230             


Ala Gln  Cys Glu Glu Glu Ile  Asn Asn Phe Cys Gly  Cys Lys Ala 
    1235                 1240                 1245             


Gly Cys  Gln Phe Pro Ala Tyr  Glu Asp Asn Pro Val  Ser Ser Gly 
    1250                 1255                 1260             


Gln Leu  Glu Glu Phe Pro Val  Leu Asn Thr Asp Ile  Gln Gly Met 
    1265                 1270                 1275             


Asn Arg  Ser Gln Glu Lys Gln  Thr Trp Trp Glu Lys  Ala Leu Tyr 
    1280                 1285                 1290             


Ser Pro  Leu Phe Pro Ala Ser  Glu Cys Glu Glu Cys  Tyr Thr Asn 
    1295                 1300                 1305             


Ala Lys  Gly Glu Ser Gly Leu  Glu Glu Tyr Pro Asp  Ala Lys Glu 
    1310                 1315                 1320             


Thr Pro  Ser Asn Glu Glu Arg  Leu Leu Asp Phe Asn  Arg Val Ser 
    1325                 1330                 1335             


Ser Val  Tyr Glu Ala Arg Cys  Thr Gly Glu Arg Asp  Ser Gly Ala 
    1340                 1345                 1350             


Lys Ser  Asp Gly Phe Arg Gly  Lys Met Cys Ser Ser  Ala Ser Ser 
    1355                 1360                 1365             


Thr Ser  Glu Glu Thr Gly Ser  Glu Gly Gly Gly Glu  Trp Val Gly 
    1370                 1375                 1380             


Pro Ser  Glu Glu Glu Leu Phe  Ser Arg Thr His Leu  
    1385                 1390                 1395 


<210>  751
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  751

Met Cys His Gly Arg Ile Ala Pro Lys Ser Thr Ser Val Phe Ala Val 
1               5                   10                  15      


Ala Ser Val Gly His Gly Val Phe Leu Pro Leu Val Ile Leu Cys Thr 
            20                  25                  30          


Leu Leu Gly Asp Gly Leu Ala Ser Val Cys Pro Leu Pro Pro Glu Pro 
        35                  40                  45              


Glu Asn Gly Gly Tyr Ile Cys His Pro Arg Pro Cys Arg Asp Pro Leu 
    50                  55                  60                  


Thr Ala Gly Ser Val Ile Glu Tyr Leu Cys Ala Glu Gly Tyr Met Leu 
65                  70                  75                  80  


Lys Gly Asp Tyr Lys Tyr Leu Thr Cys Lys Asn Gly Glu Trp Lys Pro 
                85                  90                  95      


Ala Met Glu Ile Ser Cys Arg Leu Asn Glu Asp Lys Asp Thr His Thr 
            100                 105                 110         


Ser Leu Gly Val Pro Thr Leu Ser Ile Val Ala Ser Thr Ala Ser Ser 
        115                 120                 125             


Val Ala Leu Ile Leu Leu Leu Val Val Leu Phe Val Leu Leu Gln Pro 
    130                 135                 140                 


Lys Leu Lys Ser Phe His His Ser Arg Arg Asp Gln Gly Val Ser Gly 
145                 150                 155                 160 


Asp Gln Val Ser Ile Met Val Asp Gly Val Gln Val Ala Leu Pro Ser 
                165                 170                 175     


Tyr Glu Glu Ala Val Tyr Gly Ser Ser Gly His Cys Val Pro Pro Ala 
            180                 185                 190         


Asp Pro Arg Val Gln Ile Val Leu Ser Glu Gly Ser Gly Pro Ser Gly 
        195                 200                 205             


Arg Ser Val Pro Arg Glu Gln Gln Leu Pro Asp Gln Gly Ala Cys Ser 
    210                 215                 220                 


Ser Ala Gly Gly Glu Asp Glu Ala Pro Gly Gln Ser Gly Leu Cys Glu 
225                 230                 235                 240 


Ala Trp Gly Ser Arg Ala Ser Glu Thr Val Met Val His Gln Ala Thr 
                245                 250                 255     


Thr Ser Ser Trp Val Ala Gly Ser Gly Asn Arg Gln Leu Ala His Lys 
            260                 265                 270         


Glu Thr Ala Asp Ser Glu Asn Ser Asp Ile Gln Ser Leu Leu Ser Leu 
        275                 280                 285             


Thr Ser Glu Glu Tyr Thr Asp Asp Ile Pro Leu Leu Lys Glu Ala 
    290                 295                 300             


<210>  752
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Glu Thr Pro Glu Val Pro Val Gly Ser Leu Ile Asp Phe Gly Pro 
1               5                   10                  15      


Glu Ala Pro Thr Ser Ser Pro Leu Glu Ala Pro Pro Pro Val Leu Gln 
            20                  25                  30          


Asp Gly Asp Gly Ser Leu Gly Asp Gly Ala Ser Glu Ser Glu Thr Thr 
        35                  40                  45              


Glu Ser Ala Asp Ser Glu Asn Asp Met Gly Glu Ser Pro Ser His Pro 
    50                  55                  60                  


Ser Trp Asp Gln Asp Arg Arg Ser Ser Ser Asn Glu Ser Phe Ser Ser 
65                  70                  75                  80  


Asn Gln Ser Thr Glu Ser Thr Gln Asp Glu Glu Thr Leu Ala Leu Arg 
                85                  90                  95      


Asp Phe Met Arg Gly Tyr Val Glu Lys Ile Phe Ser Gly Gly Glu Asp 
            100                 105                 110         


Leu Asp Gln Glu Glu Lys Ala Lys Phe Gly Glu Tyr Cys Ser Ser Glu 
        115                 120                 125             


Asn Gly Lys Gly Arg Glu Trp Phe Ala Arg Tyr Val Ser Ala Gln Arg 
    130                 135                 140                 


Cys Asn Ser Lys Cys Val Ser Glu Ala Thr Phe Tyr Arg Leu Val Gln 
145                 150                 155                 160 


Ser Phe Ala Val Val Leu Phe Glu Cys His Gln Met Asp Asp Phe Gly 
                165                 170                 175     


Pro Ala Lys Asn Leu Met Thr Met Cys Phe Thr Tyr Tyr His Ile Gly 
            180                 185                 190         


Lys Pro Gln Leu Leu Pro Pro Glu Ser Arg Glu Lys Pro Ala Gly Ser 
        195                 200                 205             


Ile Asp Ser Tyr Leu Lys Ser Ala Asn Ser Trp Leu Ala Glu Lys Lys 
    210                 215                 220                 


Asp Ile Ala Glu Arg Leu Leu Lys Asn Thr Ser Ala Arg Thr Glu Asn 
225                 230                 235                 240 


Val Lys Gly Phe Phe Gly Gly Leu Glu Thr Lys Leu Lys Gly Pro Leu 
                245                 250                 255     


Ala Arg Arg Asn Glu Glu Asp Glu Asn Lys Pro Gln Glu Lys Arg Pro 
            260                 265                 270         


Arg Ala Val Thr Ala Tyr Ser Pro Glu Asp Glu Lys Lys Gly Glu Lys 
        275                 280                 285             


Ile Tyr Leu Tyr Thr His Leu Lys Gln Gln Pro Ile Trp His Thr Leu 
    290                 295                 300                 


Arg Phe Trp Asn Ala Ala Phe Phe Asp Ala Val His Cys Glu Arg Thr 
305                 310                 315                 320 


Lys Arg Ser Pro Thr Thr Arg Gly Asp Ala Gly Glu Glu Glu Glu Lys 
                325                 330                 335     


Arg Glu Lys Trp Cys His Met Thr Gln Glu Glu Arg Asp Asp Ser Leu 
            340                 345                 350         


Arg Phe Asn Glu Asn Ile Thr Phe Gly Gln Leu Gly Thr Phe Thr His 
        355                 360                 365             


Asn Met Leu Ala Phe Gly Leu Asn Lys Lys Leu Cys Asn Asp Phe Leu 
    370                 375                 380                 


Lys Lys Gln Ala Val Ile Gly Asn Leu Asp Glu Glu Gln Tyr Lys Leu 
385                 390                 395                 400 


Leu Ser Asp His Ile Glu Gln Met Ala Thr Glu 
                405                 410     


<210>  753
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  753

Met Leu Met Phe Asp Pro Val Pro Val Lys Gln Glu Ala Met Asp Pro 
1               5                   10                  15      


Val Ser Val Ser Tyr Pro Ser Asn Tyr Met Glu Ser Met Lys Pro Asn 
            20                  25                  30          


Lys Tyr Gly Val Ile Tyr Ser Thr Pro Leu Pro Glu Lys Phe Phe Gln 
        35                  40                  45              


Thr Pro Glu Gly Leu Ser His Gly Ile Gln Met Glu Pro Val Asp Leu 
    50                  55                  60                  


Thr Val Asn Lys Arg Ser Ser Pro Pro Ser Ala Gly Asn Ser Pro Ser 
65                  70                  75                  80  


Ser Leu Lys Phe Pro Ser Ser His Arg Arg Ala Ser Pro Gly Leu Ser 
                85                  90                  95      


Met Pro Ser Ser Ser Pro Pro Ile Lys Lys Tyr Ser Pro Pro Ser Pro 
            100                 105                 110         


Gly Val Gln Pro Phe Gly Val Pro Leu Ser Met Pro Pro Val Met Ala 
        115                 120                 125             


Ala Ala Leu Ser Arg His Gly Ile Arg Ser Pro Gly Ile Leu Pro Val 
    130                 135                 140                 


Ile Gln Pro Val Val Val Gln Pro Val Pro Phe Met Tyr Thr Ser His 
145                 150                 155                 160 


Leu Gln Gln Pro Leu Met Val Ser Leu Ser Glu Glu Met Glu Asn Ser 
                165                 170                 175     


Ser Ser Ser Met Gln Val Pro Val Ile Glu Ser Tyr Glu Lys Pro Ile 
            180                 185                 190         


Ser Gln Lys Lys Ile Lys Ile Glu Pro Gly Ile Glu Pro Gln Arg Thr 
        195                 200                 205             


Asp Tyr Tyr Pro Glu Glu Met Ser Pro Pro Leu Met Asn Ser Val Ser 
    210                 215                 220                 


Pro Pro Gln Ala Leu Leu Gln Glu Asn His Pro Ser Val Ile Val Gln 
225                 230                 235                 240 


Pro Gly Lys Arg Pro Leu Pro Val Glu Ser Pro Asp Thr Gln Arg Lys 
                245                 250                 255     


Arg Arg Ile His Arg Cys Asp Tyr Asp Gly Cys Asn Lys Val Tyr Thr 
            260                 265                 270         


Lys Ser Ser His Leu Lys Ala His Arg Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Thr Trp Glu Gly Cys Thr Trp Lys Phe Ala Arg Ser 
    290                 295                 300                 


Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly Ile Lys Pro Phe 
305                 310                 315                 320 


Gln Cys Pro Asp Cys Asp Arg Ser Phe Ser Arg Ser Asp His Leu Ala 
                325                 330                 335     


Leu His Arg Lys Arg His Met Leu Val 
            340                 345 


<210>  754
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  754

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
        195                 200                 205             


Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
    210                 215                 220                 


Thr Gly Glu Lys Pro Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg 
225                 230                 235                 240 


Phe Ala Arg Ser Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly 
                245                 250                 255     


Ala Lys Pro Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser 
            260                 265                 270         


Asp His Leu Ala Leu His Met Lys Arg His Leu 
        275                 280             


<210>  755
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  755

Met Asp Val Leu Ala Ser Tyr Ser Ile Phe Gln Glu Leu Gln Leu Val 
1               5                   10                  15      


His Asp Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Thr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Thr Glu Pro Arg 
        35                  40                  45              


Arg Ile Ser Glu Thr Phe Gly Glu Asp Leu Asp Cys Phe Leu His Ala 
    50                  55                  60                  


Ser Pro Pro Pro Cys Ile Glu Glu Ser Phe Arg Arg Leu Asp Pro Leu 
65                  70                  75                  80  


Leu Leu Pro Val Glu Ala Ala Ile Cys Glu Lys Ser Ser Ala Val Asp 
                85                  90                  95      


Ile Leu Leu Ser Arg Asp Lys Leu Leu Ser Glu Thr Cys Leu Ser Leu 
            100                 105                 110         


Gln Pro Ala Ser Ser Ser Leu Asp Ser Tyr Thr Ala Val Asn Gln Ala 
        115                 120                 125             


Gln Leu Asn Ala Val Thr Ser Leu Thr Pro Pro Ser Ser Pro Glu Leu 
    130                 135                 140                 


Ser Arg His Leu Val Lys Thr Ser Gln Thr Leu Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Val Thr Leu Lys Leu Val Ala Lys Lys Ala Ala Leu Ser Ser Val 
                165                 170                 175     


Lys Val Gly Gly Val Ala Thr Ala Ala Ala Ala Val Thr Ala Ala Gly 
            180                 185                 190         


Ala Val Lys Ser Gly Gln Ser Asp Ser Asp Gln Gly Gly Leu Gly Ala 
        195                 200                 205             


Glu Ala Cys Pro Glu Asn Lys Lys Arg Val His Arg Cys Gln Phe Asn 
    210                 215                 220                 


Gly Cys Arg Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln 
225                 230                 235                 240 


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Trp Glu Gly Cys 
                245                 250                 255     


Glu Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys 
            260                 265                 270         


His Thr Gly Ala Lys Pro Phe Lys Cys Asn His Cys Asp Arg Cys Phe 
        275                 280                 285             


Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Ile 
    290                 295                 300         


<210>  756
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Glu Thr Pro Pro Leu Pro Pro Ala Cys Thr Lys Gln Gly His Gln 
1               5                   10                  15      


Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys His Cys Pro Val 
            20                  25                  30          


Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys Val Met Asn Glu 
        35                  40                  45              


Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile Val Ala Glu Asp 
    50                  55                  60                  


Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala Cys Ser Pro Tyr 
65                  70                  75                  80  


Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser Arg Ala Lys Arg 
                85                  90                  95      


Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg Met Leu Ile Asp 
            100                 105                 110         


Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu Asn Val Gln Val 
        115                 120                 125             


Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp Val Lys Lys Thr 
    130                 135                 140                 


Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val Asn Cys Leu Gly 
145                 150                 155                 160 


Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp Leu Leu Asn Lys 
                165                 170                 175     


Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val Val Leu Ser Glu 
            180                 185                 190         


Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser Leu Ile Ser Ser 
        195                 200                 205             


Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe Glu Ala Val Ile 
    210                 215                 220                 


Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu Phe Met Ala Arg 
225                 230                 235                 240 


Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg Glu Tyr Leu Val 
                245                 250                 255     


Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser Ser Ala Cys Lys 
            260                 265                 270         


Asp Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu Pro Thr Glu Gln 
        275                 280                 285             


Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg Thr Pro Met Asn 
    290                 295                 300                 


Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala Pro Lys Ala Ile 
305                 310                 315                 320 


Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg Trp His Gln Val 
                325                 330                 335     


Ala Glu Leu Pro Ser Arg Arg Cys Arg Ala Gly Met Val Tyr Met Ala 
            340                 345                 350         


Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser Leu Arg Val Arg 
        355                 360                 365             


Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp Thr Ser Val Ala 
    370                 375                 380                 


Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala Val Leu Asn Gly 
385                 390                 395                 400 


Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr Gly Leu Ser Ser 
                405                 410                 415     


Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe His Val Ala Pro 
            420                 425                 430         


Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val Val Gly Gly Leu 
        435                 440                 445             


Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser 
    450                 455                 460                 


Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp Thr Tyr Ile Ala 
465                 470                 475                 480 


Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly Val Leu Asn Asn 
                485                 490                 495     


Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu Val Arg Lys Ser 
            500                 505                 510         


Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg Gln Val Ala Asp 
        515                 520                 525             


Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala Val Asn Gly Leu 
    530                 535                 540                 


Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn Leu Ala Ser Val 
545                 550                 555                 560 


Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val Val Ser Ser Cys 
                565                 570                 575     


Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val Ile Asp Lys Pro 
            580                 585                 590         


Leu 
    


<210>  757
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  757

Met Phe Leu Leu Pro Leu Pro Ala Ala Gly Arg Val Val Val Arg Arg 
1               5                   10                  15      


Leu Ala Val Arg Arg Phe Gly Ser Arg Ser Leu Ser Thr Ala Asp Met 
            20                  25                  30          


Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp Asp 
        35                  40                  45              


Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu Ala 
    50                  55                  60                  


Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys Ala 
65                  70                  75                  80  


Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser Val 
                85                  90                  95      


Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln Glu 
            100                 105                 110         


Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala Gly 
        115                 120                 125             


Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp Pro 
    130                 135                 140                 


Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu Tyr 
145                 150                 155                 160 


Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala Lys 
                165                 170                 175     


Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu Phe 
            180                 185                 190         


Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala Asn 
        195                 200                 205             


Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu Lys 
    210                 215                 220                 


Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp Ile 
225                 230                 235                 240 


Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser Asp 
                245                 250                 255     


Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn Ala 
            260                 265                 270         


Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp Ser 
        275                 280                 285             


Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg Ala 
    290                 295                 300                 


Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys Glu 
                325                 330                 335     


Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg Ala 
            340                 345                 350         


Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly Arg 
        355                 360                 365             


Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro Lys 
    370                 375                 380                 


Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala Leu 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp Asn 
                405                 410                 415     


Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg Met 
            420                 425                 430         


Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu Ala 
        435                 440                 445             


Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr Ala 
    450                 455                 460                 


Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His Leu 
465                 470                 475                 480 


Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu Arg 
                485                 490                 495     


Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu Leu 
            500                 505                 510         


Arg Phe Ser Gln Asp Asn Ala 
        515                 


<210>  758
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Asp Pro Arg Leu Ser Thr Val Arg Gln Thr Cys Cys Cys Phe Asn 
1               5                   10                  15      


Val Arg Ile Ala Thr Thr Ala Leu Ala Ile Tyr His Val Ile Met Ser 
            20                  25                  30          


Val Leu Leu Phe Ile Glu His Ser Val Glu Val Ala His Gly Lys Ala 
        35                  40                  45              


Ser Cys Lys Leu Ser Gln Met Gly Tyr Leu Arg Ile Ala Asp Leu Ile 
    50                  55                  60                  


Ser Ser Phe Leu Leu Ile Thr Met Leu Phe Ile Ile Ser Leu Ser Leu 
65                  70                  75                  80  


Leu Ile Gly Val Val Lys Asn Arg Glu Lys Tyr Leu Leu Pro Phe Leu 
                85                  90                  95      


Ser Leu Gln Ile Met Asp Tyr Leu Leu Cys Leu Leu Thr Leu Leu Gly 
            100                 105                 110         


Ser Tyr Ile Glu Leu Pro Ala Tyr Leu Lys Leu Ala Ser Arg Ser Arg 
        115                 120                 125             


Ala Ser Ser Ser Lys Phe Pro Leu Met Thr Leu Gln Leu Leu Asp Phe 
    130                 135                 140                 


Cys Leu Ser Ile Leu Thr Leu Cys Ser Ser Tyr Met Glu Val Pro Thr 
145                 150                 155                 160 


Tyr Leu Asn Phe Lys Ser Met Asn His Met Asn Tyr Leu Pro Ser Gln 
                165                 170                 175     


Glu Asp Met Pro His Asn Gln Phe Ile Lys Met Met Ile Ile Phe Ser 
            180                 185                 190         


Ile Ala Phe Ile Thr Val Leu Ile Phe Lys Val Tyr Met Phe Lys Cys 
        195                 200                 205             


Val Trp Arg Cys Tyr Arg Leu Ile Lys Cys Met Asn Ser Val Glu Glu 
    210                 215                 220                 


Lys Arg Asn Ser Lys Met Leu Gln Lys Val Val Leu Pro Ser Tyr Glu 
225                 230                 235                 240 


Glu Ala Leu Ser Leu Pro Ser Lys Thr Pro Glu Gly Gly Pro Ala Pro 
                245                 250                 255     


Pro Pro Tyr Ser Glu Val 
            260         


<210>  759
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  759

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  760
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  760

Met Ala Leu Arg Asn Val Pro Phe Arg Ser Glu Val Leu Gly Trp Asp 
1               5                   10                  15      


Pro Asp Ser Leu Ala Asp Tyr Phe Lys Lys Leu Asn Tyr Lys Asp Cys 
            20                  25                  30          


Glu Lys Ala Val Lys Lys Tyr His Ile Asp Gly Ala Arg Phe Leu Asn 
        35                  40                  45              


Leu Thr Glu Asn Asp Ile Gln Lys Phe Pro Lys Leu Arg Val Pro Ile 
    50                  55                  60                  


Leu Ser Lys Leu Ser Gln Glu Ile Asn Lys Asn Glu Glu Arg Arg Ser 
65                  70                  75                  80  


Ile Phe Thr Arg Lys Pro Gln Val Pro Arg Phe Pro Glu Glu Thr Glu 
                85                  90                  95      


Ser His Glu Glu Asp Asn Gly Gly Trp Ser Ser Phe Glu Glu Asp Asp 
            100                 105                 110         


Tyr Glu Ser Pro Asn Asp Asp Gln Asp Gly Glu Asp Asp Gly Asp Tyr 
        115                 120                 125             


Glu Ser Pro Asn Glu Glu Glu Glu Ala Pro Val Glu Asp Asp Ala Asp 
    130                 135                 140                 


Tyr Glu Pro Pro Pro Ser Asn Asp Glu Glu Ala Leu Gln Asn Ser Ile 
145                 150                 155                 160 


Leu Pro Ala Lys Pro Phe Pro Asn Ser Asn Ser Met Tyr Ile Asp Arg 
                165                 170                 175     


Pro Pro Ser Gly Lys Thr Pro Gln Gln Pro Pro Val Pro Pro Gln Arg 
            180                 185                 190         


Pro Met Ala Ala Leu Pro Pro Pro Pro Ala Gly Arg Asn His Ser Pro 
        195                 200                 205             


Leu Pro Pro Pro Gln Thr Asn His Glu Glu Pro Ser Arg Ser Arg Asn 
    210                 215                 220                 


His Lys Thr Ala Lys Leu Pro Ala Pro Ser Ile Asp Arg Ser Thr Lys 
225                 230                 235                 240 


Pro Pro Leu Asp Arg Ser Leu Ala Pro Phe Asp Arg Glu Pro Phe Thr 
                245                 250                 255     


Leu Gly Lys Lys Pro Pro Phe Ser Asp Lys Pro Ser Ile Pro Ala Gly 
            260                 265                 270         


Arg Ser Leu Gly Glu His Leu Pro Lys Ile Gln Lys Pro Pro Leu Pro 
        275                 280                 285             


Pro Thr Thr Glu Arg His Glu Arg Ser Ser Pro Leu Pro Gly Lys Lys 
    290                 295                 300                 


Pro Pro Val Pro Lys His Gly Trp Gly Pro Asp Arg Arg Glu Asn Asp 
305                 310                 315                 320 


Glu Asp Asp Val His Gln Arg Pro Leu Pro Gln Pro Ala Leu Leu Pro 
                325                 330                 335     


Met Ser Ser Asn Thr Phe Pro Ser Arg Ser Thr Lys Pro Ser Pro Met 
            340                 345                 350         


Asn Pro Leu Pro Ser Ser His Met Pro Gly Ala Phe Ser Glu Ser Asn 
        355                 360                 365             


Ser Ser Phe Pro Gln Ser Ala Ser Leu Pro Pro Tyr Phe Ser Gln Gly 
    370                 375                 380                 


Pro Ser Asn Arg Pro Pro Ile Arg Ala Glu Gly Arg Asn Phe Pro Leu 
385                 390                 395                 400 


Pro Leu Pro Asn Lys Pro Arg Pro Pro Ser Pro Ala Glu Glu Glu Asn 
                405                 410                 415     


Ser Leu Asn Glu Glu Trp Tyr Val Ser Tyr Ile Thr Arg Pro Glu Ala 
            420                 425                 430         


Glu Ala Ala Leu Arg Lys Ile Asn Gln Asp Gly Thr Phe Leu Val Arg 
        435                 440                 445             


Asp Ser Ser Lys Lys Thr Thr Thr Asn Pro Tyr Val Leu Met Val Leu 
    450                 455                 460                 


Tyr Lys Asp Lys Val Tyr Asn Ile Gln Ile Arg Tyr Gln Lys Glu Ser 
465                 470                 475                 480 


Gln Val Tyr Leu Leu Gly Thr Gly Leu Arg Gly Lys Glu Asp Phe Leu 
                485                 490                 495     


Ser Val Ser Asp Ile Ile Asp Tyr Phe Arg Lys Met Pro Leu Leu Leu 
            500                 505                 510         


Ile Asp Gly Lys Asn Arg Gly Ser Arg Tyr Gln Cys Thr Leu Thr His 
        515                 520                 525             


Ala Ala Gly Tyr Pro 
    530             


<210>  761
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  761

Met Asp Ala Leu Lys Ser Ala Gly Arg Ala Leu Ile Arg Ser Pro Ser 
1               5                   10                  15      


Leu Ala Lys Gln Ser Trp Gly Gly Gly Gly Arg His Arg Lys Leu Pro 
            20                  25                  30          


Glu Asn Trp Thr Asp Thr Arg Glu Thr Leu Leu Glu Gly Met Leu Phe 
        35                  40                  45              


Ser Leu Lys Tyr Leu Gly Met Thr Leu Val Glu Gln Pro Lys Gly Glu 
    50                  55                  60                  


Glu Leu Ser Ala Ala Ala Ile Lys Arg Ile Val Ala Thr Ala Lys Ala 
65                  70                  75                  80  


Ser Gly Lys Lys Leu Gln Lys Val Thr Leu Lys Val Ser Pro Arg Gly 
                85                  90                  95      


Ile Ile Leu Thr Asp Asn Leu Thr Asn Gln Leu Ile Glu Asn Val Ser 
            100                 105                 110         


Ile Tyr Arg Ile Ser Tyr Cys Thr Ala Asp Lys Met His Asp Lys Val 
        115                 120                 125             


Phe Ala Tyr Ile Ala Gln Ser Gln His Asn Gln Ser Leu Glu Cys His 
    130                 135                 140                 


Ala Phe Leu Cys Thr Lys Arg Lys Met Ala Gln Ala Val Thr Leu Thr 
145                 150                 155                 160 


Val Ala Gln Ala Phe Lys Val Ala Phe Glu Phe Trp Gln Val Ser Lys 
                165                 170                 175     


Glu Glu Lys Glu Lys Arg Asp Lys Ala Ser Gln Glu Gly Gly Asp Val 
            180                 185                 190         


Leu Gly Ala Arg Gln Asp Cys Thr Pro Ser Leu Lys Ser Leu Val Ala 
        195                 200                 205             


Thr Gly Asn Leu Leu Asp Leu Glu Glu Thr Ala Lys Ala Pro Leu Ser 
    210                 215                 220                 


Thr Val Ser Ala Asn Thr Thr Asn Met Asp Glu Val Pro Arg Pro Gln 
225                 230                 235                 240 


Ala Leu Ser Gly Ser Ser Val Val Trp Glu Leu Asp Asp Gly Leu Asp 
                245                 250                 255     


Glu Ala Phe Ser Arg Leu Ala Gln Ser Arg Thr Asn Pro Gln Val Leu 
            260                 265                 270         


Asp Thr Gly Leu Thr Ala Gln Asp Met His Tyr Ala Gln Cys Leu Ser 
        275                 280                 285             


Pro Val Asp Trp Asp Lys Pro Asp Ser Ser Gly Thr Glu Gln Asp Asp 
    290                 295                 300                 


Leu Phe Ser Phe 
305             


<210>  762
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu 
1               5                   10                  15      


Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro 
            20                  25                  30          


Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly 
        35                  40                  45              


Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile 
    50                  55                  60                  


Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln 
65                  70                  75                  80  


Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His 
                85                  90                  95      


Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser 
            100                 105                 110         


Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn 
        115                 120                 125             


Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val 
    130                 135                 140                 


Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr 
145                 150                 155                 160 


Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser 
                165                 170                 175     


Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp 
            180                 185                 190         


Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr 
        195                 200                 205             


Pro Pro Leu Gly Trp Gln Gly Gln Pro Val Tyr Pro Ile Thr Gly Gly 
    210                 215                 220                 


Phe Arg Gln Pro Tyr Pro Ser Ser Leu Ser Val Asp Thr Ser Met Ser 
225                 230                 235                 240 


Arg Phe Ser His His Met Ile Pro Gly Pro Pro Gly Pro His Thr Thr 
                245                 250                 255     


Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val Lys Gln Glu His 
            260                 265                 270         


Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro Gln His Glu Gln 
        275                 280                 285             


Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys Lys Pro Leu Asn 
    290                 295                 300                 


Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn Val Val Ala Glu 
305                 310                 315                 320 


Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg 
                325                 330                 335     


Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala 
            340                 345                 350         


Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala 
        355                 360                 365             


Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Glu Lys Leu Gln 
    370                 375                 380                 


Glu Ser Ala Ser Gly Thr Gly Pro Arg Met Thr Ala Ala Tyr Ile 
385                 390                 395                 


<210>  763
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  763

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro Thr Val Ala Pro 
                325                 330                 335     


Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Gln Phe His Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro Leu His Leu Arg 
        355                 360                 365             


Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe Arg Met Gly Pro 
    370                 375                 380                 


Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr Ser Ser Leu Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Ala Ser Leu Gly Gln His Pro Gln Asp Tyr Thr Val Glu Asn 
            420                 425                 430         


Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val Val Leu Gly Ile 
        435                 440                 445             


Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu Gln Asp Ala Ala 
    450                 455                 460                 


Gly Arg 
465     


<210>  764
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Leu Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Arg Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro 
        275                 280                 285             


Ser His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asn Ile Leu Met Ala Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Arg Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
    530                 535                 540                 


Ala Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro 
545                 550                 555                 560 


Ser Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu 
                565                 570                 575     


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln 
            580                 585                 590         


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala 
        595                 600                 605             


Thr Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser 
    610                 615                 620                 


Ile Tyr Ala Thr Leu Ala Ile His 
625                 630         


<210>  765
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  765

Met Ser Ala Leu Ala Gly Glu Asp Val Trp Arg Cys Pro Gly Cys Gly 
1               5                   10                  15      


Asp His Ile Ala Pro Ser Gln Ile Trp Tyr Arg Thr Val Asn Glu Thr 
            20                  25                  30          


Trp His Gly Ser Cys Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr 
        35                  40                  45              


Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr 
    50                  55                  60                  


Trp Gly Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
65                  70                  75                  80  


Gly Pro Phe Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
                85                  90                  95      


Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
            100                 105                 110         


Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
        115                 120                 125             


Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu 
    130                 135                 140                 


Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
145                 150                 155                 160 


Gly Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr 
                165                 170                 175     


Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
            180                 185                 190         


Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
        195                 200                 205             


Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
    210                 215                 220                 


Ser Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
225                 230                 235                 240 


Ser Gln Arg Leu Asp Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His 
                245                 250                 255     


Met Gln Asn Ala Gly His Pro His Ala Leu Ser Thr Leu Asp Thr Lys 
            260                 265                 270         


Glu Asn Leu Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
        275                 280                 285             


Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
    290                 295                 300                 


Phe Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
305                 310                 315                 320 


Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
                325                 330                 335     


Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
            340                 345                 350         


Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
        355                 360                 365             


Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
    370                 375                 380                 


His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
385                 390                 395                 400 


Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
                405                 410                 415     


Leu Arg Ser Met Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
            420                 425                 430         


Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
        435                 440                 445             


His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
    450                 455                 460                 


Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Ala Pro Met Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg 
                485                 490                 495     


Lys Asn Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
            500                 505                 510         


Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
        515                 520                 525             


Ile Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
    530                 535                 540                 


Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
545                 550                 555                 560 


Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
                565                 570                 575     


Phe Pro Leu Ala Ala Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro 
            580                 585                 590         


Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu 
        595                 600                 605             


Gly Glu Leu Gly Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
    610                 615                 620                 


Thr Val Ser Met Gln Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
625                 630                 635             


<210>  766
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  766

Met Val Ile Met Gly Gln Cys Tyr Tyr Asn Glu Thr Ile Gly Phe Phe 
1               5                   10                  15      


Tyr Asn Asn Ser Gly Lys Glu Leu Ser Ser His Trp Arg Pro Lys Asp 
            20                  25                  30          


Val Val Val Val Ala Leu Gly Leu Thr Val Ser Val Leu Val Leu Leu 
        35                  40                  45              


Thr Asn Leu Leu Val Ile Ala Ala Ile Ala Ser Asn Arg Arg Phe His 
    50                  55                  60                  


Gln Pro Ile Tyr Tyr Leu Leu Gly Asn Leu Ala Ala Ala Asp Leu Phe 
65                  70                  75                  80  


Ala Gly Val Ala Tyr Leu Phe Leu Met Phe His Thr Gly Pro Arg Thr 
                85                  90                  95      


Ala Arg Leu Ser Leu Glu Gly Trp Phe Leu Arg Gln Gly Leu Leu Asp 
            100                 105                 110         


Thr Ser Leu Thr Ala Ser Val Ala Thr Leu Leu Ala Ile Ala Val Glu 
        115                 120                 125             


Arg His Arg Ser Val Met Ala Val Gln Leu His Ser Arg Leu Pro Arg 
    130                 135                 140                 


Gly Arg Val Val Met Leu Ile Val Gly Val Trp Val Ala Ala Leu Gly 
145                 150                 155                 160 


Leu Gly Leu Leu Pro Ala His Ser Trp His Cys Leu Cys Ala Leu Asp 
                165                 170                 175     


Arg Cys Ser Arg Met Ala Pro Leu Leu Ser Arg Ser Tyr Leu Ala Val 
            180                 185                 190         


Trp Ala Leu Ser Ser Leu Leu Val Phe Leu Leu Met Val Ala Val Tyr 
        195                 200                 205             


Thr Arg Ile Phe Phe Tyr Val Arg Arg Arg Val Gln Arg Met Ala Glu 
    210                 215                 220                 


His Val Ser Cys His Pro Arg Tyr Arg Glu Thr Thr Leu Ser Leu Val 
225                 230                 235                 240 


Lys Thr Val Val Ile Ile Leu Gly Ala Phe Val Val Cys Trp Thr Pro 
                245                 250                 255     


Gly Gln Val Val Leu Leu Leu Asp Gly Leu Gly Cys Glu Ser Cys Asn 
            260                 265                 270         


Val Leu Ala Val Glu Lys Tyr Phe Leu Leu Leu Ala Glu Ala Asn Ser 
        275                 280                 285             


Leu Val Asn Ala Ala Val Tyr Ser Cys Arg Asp Ala Glu Met Arg Arg 
    290                 295                 300                 


Thr Phe Arg Arg Leu Leu Cys Cys Ala Cys Leu Arg Gln Ser Thr Arg 
305                 310                 315                 320 


Glu Ser Val His Tyr Thr Ser Ser Ala Gln Gly Gly Ala Ser Thr Arg 
                325                 330                 335     


Ile Met Leu Pro Glu Asn Gly His Pro Leu Met Asp Ser Thr Leu 
            340                 345                 350     


<210>  767
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  767

Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Ile Val Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Lys Gly Ile Asn Gln Ala Thr Leu Ser Gly Cys Ile Asp 
            20                  25                  30          


Val Ile Val Val Gln Gln Gln Asp Gly Ser Tyr Gln Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Lys Glu Lys Val 
    50                  55                  60                  


Ile Asp Ile Glu Ile Asn Gly Ser Ala Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Asn Gly Glu Ala Phe Phe Val Glu Glu Thr Glu Glu Glu Tyr 
                85                  90                  95      


Glu Lys Leu Pro Ala Tyr Leu Ala Thr Ser Pro Ile Pro Thr Glu Asp 
            100                 105                 110         


Gln Phe Phe Lys Asp Ile Asp Thr Pro Leu Val Lys Ser Gly Gly Asp 
        115                 120                 125             


Glu Thr Pro Ser Gln Ser Ser Asp Ile Ser His Val Leu Glu Thr Glu 
    130                 135                 140                 


Thr Ile Phe Thr Pro Ser Ser Val Lys Lys Lys Lys Arg Arg Arg Lys 
145                 150                 155                 160 


Lys Tyr Lys Gln Asp Ser Lys Lys Glu Glu Gln Ala Ala Ser Ala Ala 
                165                 170                 175     


Ala Glu Asp Thr Cys Asp Val Gly Val Ser Ser Asp Asp Asp Lys Gly 
            180                 185                 190         


Ala Gln Ala Ala Arg Gly Ser Ser Asn Ala Ser Leu Lys Glu Glu Glu 
        195                 200                 205             


Cys Lys Glu Pro Leu Leu Phe His Ser Gly Asp His Tyr Pro Leu Ser 
    210                 215                 220                 


Asp Gly Asp Trp Ser Pro Leu Glu Thr Thr Tyr Pro Gln Thr Ala Cys 
225                 230                 235                 240 


Pro Lys Ser Asp Ser Glu Leu Glu Val Lys Pro Ala Glu Ser Leu Leu 
                245                 250                 255     


Arg Ser Glu Ser His Met Glu Trp Thr Trp Gly Gly Phe Pro Glu Ser 
            260                 265                 270         


Thr Lys Val Ser Lys Arg Glu Arg Ser Asp His His Pro Arg Thr Ala 
        275                 280                 285             


Thr Ile Thr Pro Ser Glu Asn Thr His Phe Arg Val Ile Pro Ser Glu 
    290                 295                 300                 


Asp Asn Leu Ile Ser Glu Val Glu Lys Asp Ala Ser Met Glu Asp Thr 
305                 310                 315                 320 


Val Cys Thr Ile Val Lys Pro Lys Pro Arg Ala Leu Gly Thr Gln Met 
                325                 330                 335     


Ser Asp Pro Thr Ser Val Ala Glu Leu Leu Glu Pro Pro Leu Glu Ser 
            340                 345                 350         


Thr Gln Ile Ser Ser Met Leu Asp Ala Asp His Leu Pro Asn Ala Ala 
        355                 360                 365             


Leu Ala Glu Ala Pro Ser Glu Ser Lys Pro Ala Ala Lys Val Asp Ser 
    370                 375                 380                 


Pro Ser Lys Lys Lys Gly Val His Lys Arg Ser Gln His Gln Gly Pro 
385                 390                 395                 400 


Asp Asp Ile Tyr Leu Asp Asp Leu Lys Gly Leu Glu Pro Glu Val Ala 
                405                 410                 415     


Ala Leu Tyr Phe Pro Lys Ser Glu Ser Glu Pro Gly Ser Arg Gln Trp 
            420                 425                 430         


Pro Glu Ser Asp Thr Leu Ser Gly Ser Gln Ser Pro Gln Ser Val Gly 
        435                 440                 445             


Ser Ala Ala Ala Asp Ser Gly Thr Glu Cys Leu Ser Asp Ser Ala Met 
    450                 455                 460                 


Asp Leu Pro Asp Val Thr Leu Ser Leu Cys Gly Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Gly Glu Ile Ser Lys Glu Lys Phe Met Glu His Ile Ile Thr Tyr His 
                485                 490                 495     


Glu Phe Ala Glu Asn Pro Gly Leu Ile Asp Asn Pro Asn Leu Val Ile 
            500                 505                 510         


Arg Ile Tyr Asn Arg Tyr Tyr Asn Trp Ala Leu Ala Ala Pro Met Ile 
        515                 520                 525             


Leu Ser Leu Gln Val Phe Gln Lys Ser Leu Pro Lys Ala Thr Val Glu 
    530                 535                 540                 


Ser Trp Val Lys Asp Lys Met Pro Lys Lys Ser Gly Arg Trp Trp Phe 
545                 550                 555                 560 


Trp Arg Lys Arg Glu Ser Met Thr Lys Gln Leu Pro Glu Ser Lys Glu 
                565                 570                 575     


Gly Lys Ser Glu Ala Pro Pro Ala Ser Asp Leu Pro Ser Ser Ser Lys 
            580                 585                 590         


Glu Pro Ala Gly Ala Arg Pro Ala Glu Asn Asp Ser Ser Ser Asp Glu 
        595                 600                 605             


Gly Ser Gln Glu Leu Glu Glu Ser Ile Thr Val Asp Pro Ile Pro Thr 
    610                 615                 620                 


Glu Pro Leu Ser His Gly Ser Thr Thr Ser Tyr Lys Lys Ser Leu Arg 
625                 630                 635                 640 


Leu Ser Ser Asp Gln Ile Ala Lys Leu Lys Leu His Asp Gly Pro Asn 
                645                 650                 655     


Asp Val Val Phe Ser Ile Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys 
            660                 665                 670         


Ala Gly Thr Ile Tyr Leu Trp Asn Trp Asn Asp Lys Ile Ile Ile Ser 
        675                 680                 685             


Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu Gly Gln Ile Leu 
    690                 695                 700                 


Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr 
705                 710                 715                 720 


His Ser Ile Asn Glu Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg 
                725                 730                 735     


Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn 
            740                 745                 750         


Asp Lys Gly Thr Ile Leu Pro Arg Gly Pro Leu Met Leu Ser Pro Ser 
        755                 760                 765             


Ser Leu Phe Ser Ala Phe His Arg Glu Val Ile Glu Lys Lys Pro Glu 
    770                 775                 780                 


Lys Phe Lys Ile Glu Cys Leu Asn Asp Ile Lys Asn Leu Phe Ala Pro 
785                 790                 795                 800 


Ser Lys Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg Pro Asn Asp Val 
                805                 810                 815     


Tyr Ala Tyr Thr Gln Val Gly Val Pro Asp Cys Arg Ile Phe Thr Val 
            820                 825                 830         


Asn Pro Lys Gly Glu Leu Ile Gln Glu Arg Thr Lys Gly Asn Lys Ser 
        835                 840                 845             


Ser Tyr His Arg Leu Ser Glu Leu Val Glu His Val Phe Pro Leu Leu 
    850                 855                 860                 


Ser Lys Glu Gln Asn Ser Ala Phe Pro Cys Pro Glu Phe Ser Ser Phe 
865                 870                 875                 880 


Cys Tyr Trp Arg Asp Pro Ile Pro Glu Val Asp Leu Asp Asp Leu Ser 
                885                 890                 895     


<210>  768
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Asn Asp Asp Pro Ser Met Glu Glu Asn Gly Val Glu Arg Val Cys 
1               5                   10                  15      


Pro Glu Ser Leu Leu Gln Ser Arg Glu Tyr Ser Ser Leu Pro Leu Pro 
            20                  25                  30          


Arg His Thr Ser Ser Thr Asp Gly Thr Ile Thr Ser Ser Asp Pro Gly 
        35                  40                  45              


Leu Glu Ile Leu Asn Met Ala Ser Cys Asp Leu Asp Arg Asn Ser Leu 
    50                  55                  60                  


Cys Lys Lys Glu Glu Asp Thr Arg Ser Ala Ser Pro Thr Ile Glu Ala 
65                  70                  75                  80  


Gln Gly Thr Ser Pro Ala His Asp Asn Ile Ala Phe Gln Asp Ser Thr 
                85                  90                  95      


Ser Lys Asp Lys Thr Ile Leu Asn Leu Glu Ala Lys Glu Glu Pro Glu 
            100                 105                 110         


Thr Ile Glu Glu His Lys Lys Glu His Ala Ser Gly Asp Ser Val Val 
        115                 120                 125             


Ser Pro Leu Pro Val Thr Thr Val Lys Ser Val Asn Leu Arg Gln Ser 
    130                 135                 140                 


Glu Asn Thr Ser Ala Asn Glu Lys Glu Val Glu Ala Glu Phe Leu Arg 
145                 150                 155                 160 


Leu Ser Leu Gly Phe Lys Cys Asp Trp Phe Thr Leu Glu Lys Arg Val 
                165                 170                 175     


Lys Leu Glu Glu Arg Ser Arg Asp Leu Ala Glu Glu Asn Leu Lys Lys 
            180                 185                 190         


Glu Ile Thr Asn Cys Leu Lys Leu Leu Glu Ser Leu Thr Pro Leu Cys 
        195                 200                 205             


Glu Asp Asp Asn Gln Ala Gln Glu Ile Ile Lys Lys Leu Glu Lys Ser 
    210                 215                 220                 


Ile Lys Phe Leu Ser Gln Cys Ala Ala Arg Val Ala Ser Arg Ala Glu 
225                 230                 235                 240 


Met Leu Gly Ala Ile Asn Gln Glu Ser Arg Val Ser Lys Ala Val Glu 
                245                 250                 255     


Val Met Ile Gln His Val Glu Asn Leu Lys Arg Met Tyr Ala Lys Glu 
            260                 265                 270         


His Ala Glu Leu Glu Glu Leu Lys Gln Val Leu Leu Gln Asn Glu Arg 
        275                 280                 285             


Ser Phe Asn Pro Leu Glu Asp Asp Asp Asp Cys Gln Ile Lys Lys Arg 
    290                 295                 300                 


Ser Ala Ser Leu Asn Ser Lys Pro Ser Ser Leu Arg Arg Val Thr Ile 
305                 310                 315                 320 


Ala Ser Leu Pro Arg Asn Ile Gly Asn Ala Gly Met Val Ala Gly Met 
                325                 330                 335     


Glu Asn Asn Asp Arg Phe Ser Arg Arg Ser Ser Ser Trp Arg Ile Leu 
            340                 345                 350         


Gly Ser Lys Gln Ser Glu His Arg Pro Ser Leu Pro Arg Phe Ile Ser 
        355                 360                 365             


Thr Tyr Ser Trp Ala Asp Ala Glu Glu Glu Lys Cys Glu Leu Lys Thr 
    370                 375                 380                 


Lys Asp Asp Ser Glu Pro Ser Gly Glu Glu Thr Val Glu Arg Thr Arg 
385                 390                 395                 400 


Lys Pro Ser Leu Ser Glu Lys Lys Asn Asn Pro Ser Lys Trp Asp Val 
                405                 410                 415     


Ser Ser Val Tyr Asp Thr Ile Ala Ser Trp Ala Thr Asn Leu Lys Ser 
            420                 425                 430         


Ser Ile Arg Lys Ala Asn Lys Ala Leu Trp Leu Ser Ile Ala Phe Ile 
        435                 440                 445             


Val Leu Phe Ala Ala Leu Met Ser Phe Leu Thr Gly Gln Leu Phe Gln 
    450                 455                 460                 


Lys Ser Val Asp Ala Ala Pro Thr Gln Gln Glu Asp Ser Trp Thr Ser 
465                 470                 475                 480 


Leu Glu His Ile Leu Trp Pro Phe Thr Arg Leu Arg His Asn Gly Pro 
                485                 490                 495     


Pro Pro Val 
            


<210>  769
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  769

Met Leu Leu Ala Thr Leu Leu Leu Leu Leu Leu Gly Gly Ala Leu Ala 
1               5                   10                  15      


His Pro Asp Arg Ile Ile Phe Pro Asn His Ala Cys Glu Asp Pro Pro 
            20                  25                  30          


Ala Val Leu Leu Glu Val Gln Gly Thr Leu Gln Arg Pro Leu Val Arg 
        35                  40                  45              


Asp Ser Arg Thr Ser Pro Ala Asn Cys Thr Trp Leu Ile Leu Gly Ser 
    50                  55                  60                  


Lys Glu Gln Thr Val Thr Ile Arg Phe Gln Lys Leu His Leu Ala Cys 
65                  70                  75                  80  


Gly Ser Glu Arg Leu Thr Leu Arg Ser Pro Leu Gln Pro Leu Ile Ser 
                85                  90                  95      


Leu Cys Glu Ala Pro Pro Ser Pro Leu Gln Leu Pro Gly Gly Asn Val 
            100                 105                 110         


Thr Ile Thr Tyr Ser Tyr Ala Gly Ala Arg Ala Pro Met Gly Gln Gly 
        115                 120                 125             


Phe Leu Leu Ser Tyr Ser Gln Asp Trp Leu Met Cys Leu Gln Glu Glu 
    130                 135                 140                 


Phe Gln Cys Leu Asn His Arg Cys Val Ser Ala Val Gln Arg Cys Asp 
145                 150                 155                 160 


Gly Val Asp Ala Cys Gly Asp Gly Ser Asp Glu Ala Gly Cys Ser Ser 
                165                 170                 175     


Asp Pro Phe Pro Gly Leu Thr Pro Arg Pro Val Pro Ser Leu Pro Cys 
            180                 185                 190         


Asn Val Thr Leu Glu Asp Phe Tyr Gly Val Phe Ser Ser Pro Gly Tyr 
        195                 200                 205             


Thr His Leu Ala Ser Val Ser His Pro Gln Ser Cys His Trp Leu Leu 
    210                 215                 220                 


Asp Pro His Asp Gly Arg Arg Leu Ala Val Arg Phe Thr Ala Leu Asp 
225                 230                 235                 240 


Leu Gly Phe Gly Asp Ala Val His Val Tyr Asp Gly Pro Gly Pro Pro 
                245                 250                 255     


Glu Ser Ser Arg Leu Leu Arg Ser Leu Thr His Phe Ser Asn Gly Lys 
            260                 265                 270         


Ala Val Thr Val Glu Thr Leu Ser Gly Gln Ala Val Val Ser Tyr His 
        275                 280                 285             


Thr Val Ala Trp Ser Asn Gly Arg Gly Phe Asn Ala Thr Tyr His Val 
    290                 295                 300                 


Arg Gly Tyr Cys Leu Pro Trp Asp Arg Pro Cys Gly Leu Gly Ser Gly 
305                 310                 315                 320 


Leu Gly Ala Gly Glu Gly Leu Gly Glu Arg Cys Tyr Ser Glu Ala Gln 
                325                 330                 335     


Arg Cys Asp Gly Ser Trp Asp Cys Ala Asp Gly Thr Asp Glu Glu Asp 
            340                 345                 350         


Cys Pro Gly Cys Pro Pro Gly His Phe Pro Cys Gly Ala Ala Gly Thr 
        355                 360                 365             


Ser Gly Ala Thr Ala Cys Tyr Leu Pro Ala Asp Arg Cys Asn Tyr Gln 
    370                 375                 380                 


Thr Phe Cys Ala Asp Gly Ala Asp Glu Arg Arg Cys Arg His Cys Gln 
385                 390                 395                 400 


Pro Gly Asn Phe Arg Cys Arg Asp Glu Lys Cys Val Tyr Glu Thr Trp 
                405                 410                 415     


Val Cys Asp Gly Gln Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp 
            420                 425                 430         


Cys Ser Tyr Val Leu Pro Arg Lys Val Ile Thr Ala Ala Val Ile Gly 
        435                 440                 445             


Ser Leu Val Cys Gly Leu Leu Leu Val Ile Ala Leu Gly Cys Thr Cys 
    450                 455                 460                 


Lys Leu Tyr Ala Ile Arg Thr Gln Glu Tyr Ser Ile Phe Ala Pro Leu 
465                 470                 475                 480 


Ser Arg Met Glu Ala Glu Ile Val Gln Gln Gln Ala Pro Pro Ser Tyr 
                485                 490                 495     


Gly Gln Leu Ile Ala Gln Gly Ala Ile Pro Pro Val Glu Asp Phe Pro 
            500                 505                 510         


Thr Glu Asn Pro Asn Asp Asn Ser Val Leu Gly Asn Leu Arg Ser Leu 
        515                 520                 525             


Leu Gln Ile Leu Arg Gln Asp Met Thr Pro Gly Gly Gly Pro Gly Ala 
    530                 535                 540                 


Arg Arg Arg Gln Arg Gly Arg Leu Met Arg Arg Leu Val Arg Arg Leu 
545                 550                 555                 560 


Arg Arg Trp Gly Leu Leu Pro Arg Thr Asn Thr Pro Ala Arg Ala Ser 
                565                 570                 575     


Glu Ala Arg Ser Gln Val Thr Pro Ser Ala Ala Pro Leu Glu Ala Leu 
            580                 585                 590         


Asp Gly Gly Thr Gly Pro Ala Arg Glu Gly Gly Ala Val Gly Gly Gln 
        595                 600                 605             


Asp Gly Glu Gln Ala Pro Pro Leu Pro Ile Lys Ala Pro Leu Pro Ser 
    610                 615                 620                 


Ala Ser Thr Ser Pro Ala Pro Thr Thr Val Pro Glu Ala Pro Gly Pro 
625                 630                 635                 640 


Leu Pro Ser Leu Pro Leu Glu Pro Ser Leu Leu Ser Gly Val Val Gln 
                645                 650                 655     


Ala Leu Arg Gly Arg Leu Leu Pro Ser Leu Gly Pro Pro Gly Pro Thr 
            660                 665                 670         


Arg Ser Pro Pro Gly Pro His Thr Ala Val Leu Ala Leu Glu Asp Glu 
        675                 680                 685             


Asp Asp Val Leu Leu Val Pro Leu Ala Glu Pro Gly Val Trp Val Ala 
    690                 695                 700                 


Glu Ala Glu Asp Glu Pro Leu Leu Thr 
705                 710             


<210>  770
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp His Leu Leu 
        35                  40                  45              


Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr Ala 
    50                  55                  60                  


Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg 
65                  70                  75                  80  


Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala 
                85                  90                  95      


Cys Ile Ala Glu Asn Lys Pro Thr 
            100                 


<210>  771
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  771

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  772
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  772

Met Cys Pro Pro Gln Ala Gln Ala Glu Val Gly Pro Thr Met Thr Glu 
1               5                   10                  15      


Lys Ala Glu Met Val Cys Ala Pro Ser Pro Ala Pro Ala Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Ser Pro Gly Pro Pro Gln Val Glu Glu Val Gly His Arg 
        35                  40                  45              


Gly Gly Ser Ser Pro Pro Arg Leu Pro Pro Gly Val Pro Val Ile Ser 
    50                  55                  60                  


Leu Gly His Ser Arg Pro Pro Gly Val Ala Met Pro Thr Thr Glu Leu 
65                  70                  75                  80  


Gly Thr Leu Arg Pro Pro Leu Leu Gln Leu Ser Thr Leu Gly Thr Ala 
                85                  90                  95      


Pro Pro Thr Leu Ala Leu His Tyr His Pro His Pro Phe Leu Asn Ser 
            100                 105                 110         


Val Tyr Ile Gly Pro Ala Gly Pro Phe Ser Ile Phe Pro Ser Ser Arg 
        115                 120                 125             


Leu Lys Arg Arg Pro Ser His Cys Glu Leu Asp Leu Ala Glu Gly His 
    130                 135                 140                 


Gln Pro Gln Lys Val Ala Arg Arg Val Phe Thr Asn Ser Arg Glu Arg 
145                 150                 155                 160 


Trp Arg Gln Gln Asn Val Asn Gly Ala Phe Ala Glu Leu Arg Lys Leu 
                165                 170                 175     


Leu Pro Thr His Pro Pro Asp Arg Lys Leu Ser Lys Asn Glu Val Leu 
            180                 185                 190         


Arg Leu Ala Met Lys Tyr Ile Gly Phe Leu Val Arg Leu Leu Arg Asp 
        195                 200                 205             


Gln Ala Ala Ala Leu Ala Ala Gly Pro Thr Pro Pro Gly Pro Arg Lys 
    210                 215                 220                 


Arg Pro Val His Arg Val Pro Asp Asp Gly Ala Arg Arg Gly Ser Gly 
225                 230                 235                 240 


Arg Arg Ala Glu Ala Ala Ala Arg Ser Gln Pro Ala Pro Pro Ala Asp 
                245                 250                 255     


Pro Asp Gly Ser Pro Gly Gly Ala Ala Arg Pro Ile Lys Met Glu Gln 
            260                 265                 270         


Thr Ala Leu Ser Pro Glu Val Arg 
        275                 280 


<210>  773
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  773

Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Arg Asn Thr Glu Arg Thr Ile Tyr 
            20                  25                  30          


Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro Val Pro Glu Ser 
        35                  40                  45              


Gln Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln 
    50                  55                  60                  


Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp 
65                  70                  75                  80  


Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val Leu Glu Glu His 
                85                  90                  95      


Gly Glu Trp Trp Lys Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe 
            100                 105                 110         


Ile Pro Ser Asn Tyr Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu 
        115                 120                 125             


Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu 
    130                 135                 140                 


Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr 
145                 150                 155                 160 


Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Pro Val His 
                165                 170                 175     


Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly 
            180                 185                 190         


Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile 
        195                 200                 205             


Lys His Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys 
    210                 215                 220                 


Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp 
225                 230                 235                 240 


Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly 
                245                 250                 255     


Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val 
            260                 265                 270         


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu 
        275                 280                 285             


Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg 
    290                 295                 300                 


Leu Tyr Ala Val Val Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu 
305                 310                 315                 320 


Tyr Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly 
                325                 330                 335     


Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala 
            340                 345                 350         


Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu 
        355                 360                 365             


Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
385                 390                 395                 400 


Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn 
                405                 410                 415     


Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
            420                 425                 430         


Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr 
        435                 440                 445             


Asn Ala Asp Val Met Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg 
    450                 455                 460                 


Val Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp 
465                 470                 475                 480 


Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val 
                485                 490                 495     


Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
            500                 505                 510         


<210>  774
<211>  3801
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Ser Thr Asp Ser Asn Ser Leu Ala Arg Glu Phe Leu Thr Asp Val 
1               5                   10                  15      


Asn Arg Leu Cys Asn Ala Val Val Gln Arg Val Glu Ala Arg Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Thr His Met Ala Thr Leu Gly Gln Tyr Leu Val His 
        35                  40                  45              


Gly Arg Gly Phe Leu Leu Leu Thr Lys Leu Asn Ser Ile Ile Asp Gln 
    50                  55                  60                  


Ala Leu Thr Cys Arg Glu Glu Leu Leu Thr Leu Leu Leu Ser Leu Leu 
65                  70                  75                  80  


Pro Leu Val Trp Lys Ile Pro Val Gln Glu Glu Lys Ala Thr Asp Phe 
                85                  90                  95      


Asn Leu Pro Leu Ser Ala Asp Ile Ile Leu Thr Lys Glu Lys Asn Ser 
            100                 105                 110         


Ser Ser Gln Arg Ser Thr Gln Glu Lys Leu His Leu Glu Gly Ser Ala 
        115                 120                 125             


Leu Ser Ser Gln Val Ser Ala Lys Val Asn Val Phe Arg Lys Ser Arg 
    130                 135                 140                 


Arg Gln Arg Lys Ile Thr His Arg Tyr Ser Val Arg Asp Ala Arg Lys 
145                 150                 155                 160 


Thr Gln Leu Ser Thr Ser Asp Ser Glu Ala Asn Ser Asp Glu Lys Gly 
                165                 170                 175     


Ile Ala Met Asn Lys His Arg Arg Pro His Leu Leu His His Phe Leu 
            180                 185                 190         


Thr Ser Phe Pro Lys Gln Asp His Pro Lys Ala Lys Leu Asp Arg Leu 
        195                 200                 205             


Ala Thr Lys Glu Gln Thr Pro Pro Asp Ala Met Ala Leu Glu Asn Ser 
    210                 215                 220                 


Arg Glu Ile Ile Pro Arg Gln Gly Ser Asn Thr Asp Ile Leu Ser Glu 
225                 230                 235                 240 


Pro Ala Ala Leu Ser Val Ile Ser Asn Met Asn Asn Ser Pro Phe Asp 
                245                 250                 255     


Leu Cys His Val Leu Leu Ser Leu Leu Glu Lys Val Cys Lys Phe Asp 
            260                 265                 270         


Val Thr Leu Asn His Asn Ser Pro Leu Ala Ala Ser Val Val Pro Thr 
        275                 280                 285             


Leu Thr Glu Phe Leu Ala Gly Phe Gly Asp Cys Cys Ser Leu Ser Asp 
    290                 295                 300                 


Asn Leu Glu Ser Arg Val Val Ser Ala Gly Trp Thr Glu Glu Pro Val 
305                 310                 315                 320 


Ala Leu Ile Gln Arg Met Leu Phe Arg Thr Val Leu His Leu Leu Ser 
                325                 330                 335     


Val Asp Val Ser Thr Ala Glu Met Met Pro Glu Asn Leu Arg Lys Asn 
            340                 345                 350         


Leu Thr Glu Leu Leu Arg Ala Ala Leu Lys Ile Arg Ile Cys Leu Glu 
        355                 360                 365             


Lys Gln Pro Asp Pro Phe Ala Pro Arg Gln Lys Lys Thr Leu Gln Glu 
    370                 375                 380                 


Val Gln Glu Asp Phe Val Phe Ser Lys Tyr Arg His Arg Ala Leu Leu 
385                 390                 395                 400 


Leu Pro Glu Leu Leu Glu Gly Val Leu Gln Ile Leu Ile Cys Cys Leu 
                405                 410                 415     


Gln Ser Ala Ala Ser Asn Pro Phe Tyr Phe Ser Gln Ala Met Asp Leu 
            420                 425                 430         


Val Gln Glu Phe Ile Gln His His Gly Phe Asn Leu Phe Glu Thr Ala 
        435                 440                 445             


Val Leu Gln Met Glu Trp Leu Val Leu Arg Asp Gly Val Pro Pro Glu 
    450                 455                 460                 


Ala Ser Glu His Leu Lys Ala Leu Ile Asn Ser Val Met Lys Ile Met 
465                 470                 475                 480 


Ser Thr Val Lys Lys Val Lys Ser Glu Gln Leu His His Ser Met Cys 
                485                 490                 495     


Thr Arg Lys Arg His Arg Arg Cys Glu Tyr Ser His Phe Met His His 
            500                 505                 510         


His Arg Asp Leu Ser Gly Leu Leu Val Ser Ala Phe Lys Asn Gln Val 
        515                 520                 525             


Ser Lys Asn Pro Phe Glu Glu Thr Ala Asp Gly Asp Val Tyr Tyr Pro 
    530                 535                 540                 


Glu Arg Cys Cys Cys Ile Ala Val Cys Ala His Gln Cys Leu Arg Leu 
545                 550                 555                 560 


Leu Gln Gln Ala Ser Leu Ser Ser Thr Cys Val Gln Ile Leu Ser Gly 
                565                 570                 575     


Val His Asn Ile Gly Ile Cys Cys Cys Met Asp Pro Lys Ser Val Ile 
            580                 585                 590         


Ile Pro Leu Leu His Ala Phe Lys Leu Pro Ala Leu Lys Asn Phe Gln 
        595                 600                 605             


Gln His Ile Leu Asn Ile Leu Asn Lys Leu Ile Leu Asp Gln Leu Gly 
    610                 615                 620                 


Gly Ala Glu Ile Ser Pro Lys Ile Lys Lys Ala Ala Cys Asn Ile Cys 
625                 630                 635                 640 


Thr Val Asp Ser Asp Gln Leu Ala Gln Leu Glu Glu Thr Leu Gln Gly 
                645                 650                 655     


Asn Leu Cys Asp Ala Glu Leu Ser Ser Ser Leu Ser Ser Pro Ser Tyr 
            660                 665                 670         


Arg Phe Gln Gly Ile Leu Pro Ser Ser Gly Ser Glu Asp Leu Leu Trp 
        675                 680                 685             


Lys Trp Asp Ala Leu Lys Ala Tyr Gln Asn Phe Val Phe Glu Glu Asp 
    690                 695                 700                 


Arg Leu His Ser Ile Gln Ile Ala Asn His Ile Cys Asn Leu Ile Gln 
705                 710                 715                 720 


Lys Gly Asn Ile Val Val Gln Trp Lys Leu Tyr Asn Tyr Ile Phe Asn 
                725                 730                 735     


Pro Val Leu Gln Arg Gly Val Glu Leu Ala His His Cys Gln His Leu 
            740                 745                 750         


Ser Val Thr Ser Ala Gln Ser His Val Cys Ser His His Asn Gln Cys 
        755                 760                 765             


Leu Pro Gln Asp Val Leu Gln Ile Tyr Val Lys Thr Leu Pro Ile Leu 
    770                 775                 780                 


Leu Lys Ser Arg Val Ile Arg Asp Leu Phe Leu Ser Cys Asn Gly Val 
785                 790                 795                 800 


Ser Gln Ile Ile Glu Leu Asn Cys Leu Asn Gly Ile Arg Ser His Ser 
                805                 810                 815     


Leu Lys Ala Phe Glu Thr Leu Ile Ile Ser Leu Gly Glu Gln Gln Lys 
            820                 825                 830         


Asp Ala Ser Val Pro Asp Ile Asp Gly Ile Asp Ile Glu Gln Lys Glu 
        835                 840                 845             


Leu Ser Ser Val His Val Gly Thr Ser Phe His His Gln Gln Ala Tyr 
    850                 855                 860                 


Ser Asp Ser Pro Gln Ser Leu Ser Lys Phe Tyr Ala Gly Leu Lys Glu 
865                 870                 875                 880 


Ala Tyr Pro Lys Arg Arg Lys Thr Val Asn Gln Asp Val His Ile Asn 
                885                 890                 895     


Thr Ile Asn Leu Phe Leu Cys Val Ala Phe Leu Cys Val Ser Lys Glu 
            900                 905                 910         


Ala Glu Ser Asp Arg Glu Ser Ala Asn Asp Ser Glu Asp Thr Ser Gly 
        915                 920                 925             


Tyr Asp Ser Thr Ala Ser Glu Pro Leu Ser His Met Leu Pro Cys Ile 
    930                 935                 940                 


Ser Leu Glu Ser Leu Val Leu Pro Ser Pro Glu His Met His Gln Ala 
945                 950                 955                 960 


Ala Asp Ile Trp Ser Met Cys Arg Trp Ile Tyr Met Leu Ser Ser Val 
                965                 970                 975     


Phe Gln Lys Gln Phe Tyr Arg Leu Gly Gly Phe Arg Val Cys His Lys 
            980                 985                 990         


Leu Ile Phe Met Ile Ile Gln Lys  Leu Phe Arg Ser His  Lys Glu Glu 
        995                 1000                 1005             


Gln Gly  Lys Lys Glu Gly Asp  Thr Ser Val Asn Glu  Asn Gln Asp 
    1010                 1015                 1020             


Leu Asn  Arg Ile Ser Gln Pro  Lys Arg Thr Met Lys  Glu Asp Leu 
    1025                 1030                 1035             


Leu Ser  Leu Ala Ile Lys Ser  Asp Pro Ile Pro Ser  Glu Leu Gly 
    1040                 1045                 1050             


Ser Leu  Lys Lys Ser Ala Asp  Ser Leu Gly Lys Leu  Glu Leu Gln 
    1055                 1060                 1065             


His Ile  Ser Ser Ile Asn Val  Glu Glu Val Ser Ala  Thr Glu Ala 
    1070                 1075                 1080             


Ala Pro  Glu Glu Ala Lys Leu  Phe Thr Ser Gln Glu  Ser Glu Thr 
    1085                 1090                 1095             


Ser Leu  Gln Ser Ile Arg Leu  Leu Glu Ala Leu Leu  Ala Ile Cys 
    1100                 1105                 1110             


Leu His  Gly Ala Arg Thr Ser  Gln Gln Lys Met Glu  Leu Glu Leu 
    1115                 1120                 1125             


Pro Asn  Gln Asn Leu Ser Val  Glu Ser Ile Leu Phe  Glu Met Arg 
    1130                 1135                 1140             


Asp His  Leu Ser Gln Ser Lys  Val Ile Glu Thr Gln  Leu Ala Lys 
    1145                 1150                 1155             


Pro Leu  Phe Asp Ala Leu Leu  Arg Val Ala Leu Gly  Asn Tyr Ser 
    1160                 1165                 1170             


Ala Asp  Phe Glu His Asn Asp  Ala Met Thr Glu Lys  Ser His Gln 
    1175                 1180                 1185             


Ser Ala  Glu Glu Leu Ser Ser  Gln Pro Gly Asp Phe  Ser Glu Glu 
    1190                 1195                 1200             


Ala Glu  Asp Ser Gln Cys Cys  Ser Phe Lys Leu Leu  Val Glu Glu 
    1205                 1210                 1215             


Glu Gly  Tyr Glu Ala Asp Ser  Glu Ser Asn Pro Glu  Asp Gly Glu 
    1220                 1225                 1230             


Thr Gln  Asp Asp Gly Val Asp  Leu Lys Ser Glu Thr  Glu Gly Phe 
    1235                 1240                 1245             


Ser Ala  Ser Ser Ser Pro Asn  Asp Leu Leu Glu Asn  Leu Thr Gln 
    1250                 1255                 1260             


Gly Glu  Ile Ile Tyr Pro Glu  Ile Cys Met Leu Glu  Leu Asn Leu 
    1265                 1270                 1275             


Leu Ser  Ala Ser Lys Ala Lys  Leu Asp Val Leu Ala  His Val Phe 
    1280                 1285                 1290             


Glu Ser  Phe Leu Lys Ile Ile  Arg Gln Lys Glu Lys  Asn Val Phe 
    1295                 1300                 1305             


Leu Leu  Met Gln Gln Gly Thr  Val Lys Asn Leu Leu  Gly Gly Phe 
    1310                 1315                 1320             


Leu Ser  Ile Leu Thr Gln Asp  Asp Ser Asp Phe Gln  Ala Cys Gln 
    1325                 1330                 1335             


Arg Val  Leu Val Asp Leu Leu  Val Ser Leu Met Ser  Ser Arg Thr 
    1340                 1345                 1350             


Cys Ser  Glu Glu Leu Thr Leu  Leu Leu Arg Ile Phe  Leu Glu Lys 
    1355                 1360                 1365             


Ser Pro  Cys Thr Lys Ile Leu  Leu Leu Gly Ile Leu  Lys Ile Ile 
    1370                 1375                 1380             


Glu Ser  Asp Thr Thr Met Ser  Pro Ser Gln Tyr Leu  Thr Phe Pro 
    1385                 1390                 1395             


Leu Leu  His Ala Pro Asn Leu  Ser Asn Gly Val Ser  Ser Gln Lys 
    1400                 1405                 1410             


Tyr Pro  Gly Ile Leu Asn Ser  Lys Ala Met Gly Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ala Arg  Val Ser Arg Ser Lys  Lys Glu Ala Asp Arg  Glu Ser Phe 
    1430                 1435                 1440             


Pro His  Arg Leu Leu Ser Ser  Trp His Ile Ala Pro  Val His Leu 
    1445                 1450                 1455             


Pro Leu  Leu Gly Gln Asn Cys  Trp Pro His Leu Ser  Glu Gly Phe 
    1460                 1465                 1470             


Ser Val  Ser Leu Trp Phe Asn  Val Glu Cys Ile His  Glu Ala Glu 
    1475                 1480                 1485             


Ser Thr  Thr Glu Lys Gly Lys  Lys Ile Lys Lys Arg  Asn Lys Ser 
    1490                 1495                 1500             


Leu Ile  Leu Pro Asp Ser Ser  Phe Asp Gly Thr Glu  Ser Asp Arg 
    1505                 1510                 1515             


Pro Glu  Gly Ala Glu Tyr Ile  Asn Pro Gly Glu Arg  Leu Ile Glu 
    1520                 1525                 1530             


Glu Gly  Cys Ile His Ile Ile  Ser Leu Gly Ser Lys  Ala Leu Met 
    1535                 1540                 1545             


Ile Gln  Val Trp Ala Asp Pro  His Asn Ala Thr Leu  Ile Phe Arg 
    1550                 1555                 1560             


Val Cys  Met Asp Ser Asn Asp  Asp Met Lys Ala Val  Leu Leu Ala 
    1565                 1570                 1575             


Gln Val  Glu Ser Gln Glu Asn  Ile Phe Leu Pro Ser  Lys Trp Gln 
    1580                 1585                 1590             


His Leu  Val Leu Thr Tyr Leu  Gln Gln Pro Gln Gly  Lys Arg Arg 
    1595                 1600                 1605             


Ile His  Gly Lys Ile Ser Ile  Trp Val Ser Gly Gln  Arg Lys Pro 
    1610                 1615                 1620             


Asp Val  Thr Leu Asp Phe Met  Leu Pro Arg Lys Thr  Ser Leu Ser 
    1625                 1630                 1635             


Ser Asp  Ser Asn Lys Thr Phe  Cys Met Ile Gly His  Cys Leu Ser 
    1640                 1645                 1650             


Ser Gln  Glu Glu Phe Leu Gln  Leu Ala Gly Lys Trp  Asp Leu Gly 
    1655                 1660                 1665             


Asn Leu  Leu Leu Phe Asn Gly  Ala Lys Val Gly Ser  Gln Glu Ala 
    1670                 1675                 1680             


Phe Tyr  Leu Tyr Ala Cys Gly  Pro Asn His Thr Ser  Val Met Pro 
    1685                 1690                 1695             


Cys Lys  Tyr Gly Lys Pro Val  Asn Asp Tyr Ser Lys  Tyr Ile Asn 
    1700                 1705                 1710             


Lys Glu  Ile Leu Arg Cys Glu  Gln Ile Arg Glu Leu  Phe Met Thr 
    1715                 1720                 1725             


Lys Lys  Asp Val Asp Ile Gly  Leu Leu Ile Glu Ser  Leu Ser Val 
    1730                 1735                 1740             


Val Tyr  Thr Thr Tyr Cys Pro  Ala Gln Tyr Thr Ile  Tyr Glu Pro 
    1745                 1750                 1755             


Val Ile  Arg Leu Lys Gly Gln  Met Lys Thr Gln Leu  Ser Gln Arg 
    1760                 1765                 1770             


Pro Phe  Ser Ser Lys Glu Val  Gln Ser Ile Leu Leu  Glu Pro His 
    1775                 1780                 1785             


His Leu  Lys Asn Leu Gln Pro  Thr Glu Tyr Lys Thr  Ile Gln Gly 
    1790                 1795                 1800             


Ile Leu  His Glu Ile Gly Gly  Thr Gly Ile Phe Val  Phe Leu Phe 
    1805                 1810                 1815             


Ala Arg  Val Val Glu Leu Ser  Ser Cys Glu Glu Thr  Gln Ala Leu 
    1820                 1825                 1830             


Ala Leu  Arg Val Ile Leu Ser  Leu Ile Lys Tyr Asn  Gln Gln Arg 
    1835                 1840                 1845             


Val His  Glu Leu Glu Asn Cys  Asn Gly Leu Ser Met  Ile His Gln 
    1850                 1855                 1860             


Val Leu  Ile Lys Gln Lys Cys  Ile Val Gly Phe Tyr  Ile Leu Lys 
    1865                 1870                 1875             


Thr Leu  Leu Glu Gly Cys Cys  Gly Glu Asp Ile Ile  Tyr Met Asn 
    1880                 1885                 1890             


Glu Asn  Gly Glu Phe Lys Leu  Asp Val Asp Ser Asn  Ala Ile Ile 
    1895                 1900                 1905             


Gln Asp  Val Lys Leu Leu Glu  Glu Leu Leu Leu Asp  Trp Lys Ile 
    1910                 1915                 1920             


Trp Ser  Lys Ala Glu Gln Gly  Val Trp Glu Thr Leu  Leu Ala Ala 
    1925                 1930                 1935             


Leu Glu  Val Leu Ile Arg Ala  Asp His His Gln Gln  Met Phe Asn 
    1940                 1945                 1950             


Ile Lys  Gln Leu Leu Lys Ala  Gln Val Val His His  Phe Leu Leu 
    1955                 1960                 1965             


Thr Cys  Gln Val Leu Gln Glu  Tyr Lys Glu Gly Gln  Leu Thr Pro 
    1970                 1975                 1980             


Met Pro  Arg Glu Val Cys Arg  Ser Phe Val Lys Ile  Ile Ala Glu 
    1985                 1990                 1995             


Val Leu  Gly Ser Pro Pro Asp  Leu Glu Leu Leu Thr  Ile Ile Phe 
    2000                 2005                 2010             


Asn Phe  Leu Leu Ala Val His  Pro Pro Thr Asn Thr  Tyr Val Cys 
    2015                 2020                 2025             


His Asn  Pro Thr Asn Phe Tyr  Phe Ser Leu His Ile  Asp Gly Lys 
    2030                 2035                 2040             


Ile Phe  Gln Glu Lys Val Arg  Ser Ile Met Tyr Leu  Arg His Ser 
    2045                 2050                 2055             


Ser Ser  Gly Gly Arg Ser Leu  Met Ser Pro Gly Phe  Met Val Ile 
    2060                 2065                 2070             


Ser Pro  Ser Gly Phe Thr Ala  Ser Pro Tyr Glu Gly  Glu Asn Ser 
    2075                 2080                 2085             


Ser Asn  Ile Ile Pro Gln Gln  Met Ala Ala His Met  Leu Arg Ser 
    2090                 2095                 2100             


Arg Ser  Leu Pro Ala Phe Pro  Thr Ser Ser Leu Leu  Thr Gln Ser 
    2105                 2110                 2115             


Gln Lys  Leu Thr Gly Ser Leu  Gly Cys Ser Ile Asp  Arg Leu Gln 
    2120                 2125                 2130             


Asn Ile  Ala Asp Thr Tyr Val  Ala Thr Gln Ser Lys  Lys Gln Asn 
    2135                 2140                 2145             


Ser Leu  Gly Ser Ser Asp Thr  Leu Lys Lys Gly Lys  Glu Asp Ala 
    2150                 2155                 2160             


Phe Ile  Ser Ser Cys Glu Ser  Ala Lys Thr Val Cys  Glu Met Glu 
    2165                 2170                 2175             


Ala Val  Leu Ser Ala Gln Val  Ser Val Ser Asp Val  Pro Lys Gly 
    2180                 2185                 2190             


Val Leu  Gly Phe Pro Val Val  Lys Ala Asp His Lys  Gln Leu Gly 
    2195                 2200                 2205             


Ala Glu  Pro Arg Ser Glu Asp  Asp Ser Pro Gly Asp  Glu Ser Cys 
    2210                 2215                 2220             


Pro Arg  Arg Pro Asp Tyr Leu  Lys Gly Leu Ala Ser  Phe Gln Arg 
    2225                 2230                 2235             


Ser His  Ser Thr Ile Ala Ser  Leu Gly Leu Ala Phe  Pro Ser Gln 
    2240                 2245                 2250             


Asn Gly  Ser Ala Ala Val Gly  Arg Trp Pro Ser Leu  Val Asp Arg 
    2255                 2260                 2265             


Asn Thr  Asp Asp Trp Glu Asn  Phe Ala Tyr Ser Leu  Gly Tyr Glu 
    2270                 2275                 2280             


Pro Asn  Tyr Asn Arg Thr Ala  Ser Ala His Ser Val  Thr Glu Asp 
    2285                 2290                 2295             


Cys Leu  Val Pro Ile Cys Cys  Gly Leu Tyr Glu Leu  Leu Ser Gly 
    2300                 2305                 2310             


Val Leu  Leu Ile Leu Pro Asp  Val Leu Leu Glu Asp  Val Met Asp 
    2315                 2320                 2325             


Lys Leu  Ile Gln Ala Asp Thr  Leu Leu Val Leu Val  Asn His Pro 
    2330                 2335                 2340             


Ser Pro  Ala Ile Gln Gln Gly  Val Ile Lys Leu Leu  Asp Ala Tyr 
    2345                 2350                 2355             


Phe Ala  Arg Ala Ser Lys Glu  Gln Lys Asp Lys Phe  Leu Lys Asn 
    2360                 2365                 2370             


Arg Gly  Phe Ser Leu Leu Ala  Asn Gln Leu Tyr Leu  His Arg Gly 
    2375                 2380                 2385             


Thr Gln  Glu Leu Leu Glu Cys  Phe Ile Glu Met Phe  Phe Gly Arg 
    2390                 2395                 2400             


His Ile  Gly Leu Asp Glu Glu  Phe Asp Leu Glu Asp  Val Arg Asn 
    2405                 2410                 2415             


Met Gly  Leu Phe Gln Lys Trp  Ser Val Ile Pro Ile  Leu Gly Leu 
    2420                 2425                 2430             


Ile Glu  Thr Ser Leu Tyr Asp  Asn Ile Leu Leu His  Asn Ala Leu 
    2435                 2440                 2445             


Leu Leu  Leu Leu Gln Ile Leu  Asn Ser Cys Ser Lys  Val Ala Asp 
    2450                 2455                 2460             


Met Leu  Leu Asp Asn Gly Leu  Leu Tyr Val Leu Cys  Asn Thr Val 
    2465                 2470                 2475             


Ala Ala  Leu Asn Gly Leu Glu  Lys Asn Ile Pro Met  Ser Glu Tyr 
    2480                 2485                 2490             


Lys Leu  Leu Ala Cys Asp Ile  Gln Gln Leu Phe Ile  Ala Val Thr 
    2495                 2500                 2505             


Ile His  Ala Cys Ser Ser Ser  Gly Ser Gln Tyr Phe  Arg Val Ile 
    2510                 2515                 2520             


Glu Asp  Leu Ile Val Met Leu  Gly Tyr Leu Gln Asn  Ser Lys Asn 
    2525                 2530                 2535             


Lys Arg  Thr Gln Asn Met Ala  Val Ala Leu Gln Leu  Arg Val Leu 
    2540                 2545                 2550             


Gln Ala  Ala Met Glu Phe Ile  Arg Thr Thr Ala Asn  His Asp Ser 
    2555                 2560                 2565             


Glu Asn  Leu Thr Asp Ser Leu  Gln Ser Pro Ser Ala  Pro His His 
    2570                 2575                 2580             


Ala Val  Val Gln Lys Arg Lys  Ser Ile Ala Gly Pro  Arg Lys Phe 
    2585                 2590                 2595             


Pro Leu  Ala Gln Thr Glu Ser  Leu Leu Met Lys Met  Arg Ser Val 
    2600                 2605                 2610             


Ala Asn  Asp Glu Leu His Val  Met Met Gln Arg Arg  Met Ser Gln 
    2615                 2620                 2625             


Glu Asn  Pro Ser Gln Ala Thr  Glu Thr Glu Leu Ala  Gln Arg Leu 
    2630                 2635                 2640             


Gln Arg  Leu Thr Val Leu Ala  Val Asn Arg Ile Ile  Tyr Gln Glu 
    2645                 2650                 2655             


Phe Asn  Ser Asp Ile Ile Asp  Ile Leu Arg Thr Pro  Glu Asn Val 
    2660                 2665                 2670             


Thr Gln  Ser Lys Thr Ser Val  Phe Gln Thr Glu Ile  Ser Glu Glu 
    2675                 2680                 2685             


Asn Ile  His His Glu Gln Ser  Ser Val Phe Asn Pro  Phe Gln Lys 
    2690                 2695                 2700             


Glu Ile  Phe Thr Tyr Leu Val  Glu Gly Phe Lys Val  Ser Ile Gly 
    2705                 2710                 2715             


Ser Ser  Lys Ala Ser Gly Ser  Lys Gln Gln Trp Thr  Lys Ile Leu 
    2720                 2725                 2730             


Trp Ser  Cys Lys Glu Thr Phe  Arg Met Gln Leu Gly  Arg Leu Leu 
    2735                 2740                 2745             


Val His  Ile Leu Ser Pro Ala  His Ala Ala Gln Glu  Arg Lys Gln 
    2750                 2755                 2760             


Ile Phe  Glu Ile Val His Glu  Pro Asn His Gln Glu  Ile Leu Arg 
    2765                 2770                 2775             


Asp Cys  Leu Ser Pro Ser Leu  Gln His Gly Ala Lys  Leu Val Leu 
    2780                 2785                 2790             


Tyr Leu  Ser Glu Leu Ile His  Asn His Gln Gly Glu  Leu Thr Glu 
    2795                 2800                 2805             


Glu Glu  Leu Gly Thr Ala Glu  Leu Leu Met Asn Ala  Leu Lys Leu 
    2810                 2815                 2820             


Cys Gly  His Lys Cys Ile Pro  Pro Ser Ala Ser Thr  Lys Ala Asp 
    2825                 2830                 2835             


Leu Ile  Lys Met Ile Lys Glu  Glu Gln Lys Lys Tyr  Glu Thr Glu 
    2840                 2845                 2850             


Glu Gly  Val Asn Lys Ala Ala  Trp Gln Lys Thr Val  Asn Asn Asn 
    2855                 2860                 2865             


Gln Gln  Ser Leu Phe Gln Arg  Leu Asp Ser Lys Ser  Lys Asp Ile 
    2870                 2875                 2880             


Ser Lys  Ile Ala Ala Asp Ile  Thr Gln Ala Val Ser  Leu Ser Gln 
    2885                 2890                 2895             


Gly Asn  Glu Arg Lys Lys Val  Ile Gln His Ile Arg  Gly Met Tyr 
    2900                 2905                 2910             


Lys Val  Asp Leu Ser Ala Ser  Arg His Trp Gln Glu  Leu Ile Gln 
    2915                 2920                 2925             


Gln Leu  Thr His Asp Arg Ala  Val Trp Tyr Asp Pro  Ile Tyr Tyr 
    2930                 2935                 2940             


Pro Thr  Ser Trp Gln Leu Asp  Pro Thr Glu Gly Pro  Asn Arg Glu 
    2945                 2950                 2955             


Arg Arg  Arg Leu Gln Arg Cys  Tyr Leu Thr Ile Pro  Asn Lys Tyr 
    2960                 2965                 2970             


Leu Leu  Arg Asp Arg Gln Lys  Ser Glu Asp Val Val  Lys Pro Pro 
    2975                 2980                 2985             


Leu Ser  Tyr Leu Phe Glu Asp  Lys Thr His Ser Ser  Phe Ser Ser 
    2990                 2995                 3000             


Thr Val  Lys Asp Lys Ala Ala  Ser Glu Ser Ile Arg  Val Asn Arg 
    3005                 3010                 3015             


Arg Cys  Ile Ser Val Ala Pro  Ser Arg Glu Thr Ala  Gly Glu Leu 
    3020                 3025                 3030             


Leu Leu  Gly Lys Cys Gly Met  Tyr Phe Val Glu Asp  Asn Ala Ser 
    3035                 3040                 3045             


Asp Thr  Val Glu Ser Ser Ser  Leu Gln Gly Glu Leu  Glu Pro Ala 
    3050                 3055                 3060             


Ser Phe  Ser Trp Thr Tyr Glu  Glu Ile Lys Glu Val  His Lys Arg 
    3065                 3070                 3075             


Trp Trp  Gln Leu Arg Asp Asn  Ala Val Glu Ile Phe  Leu Thr Asn 
    3080                 3085                 3090             


Gly Arg  Thr Leu Leu Leu Ala  Phe Asp Asn Thr Lys  Val Arg Asp 
    3095                 3100                 3105             


Asp Val  Tyr His Asn Ile Leu  Thr Asn Asn Leu Pro  Asn Leu Leu 
    3110                 3115                 3120             


Glu Tyr  Gly Asn Ile Thr Ala  Leu Thr Asn Leu Trp  Tyr Thr Gly 
    3125                 3130                 3135             


Gln Ile  Thr Asn Phe Glu Tyr  Leu Thr His Leu Asn  Lys His Ala 
    3140                 3145                 3150             


Gly Arg  Ser Phe Asn Asp Leu  Met Gln Tyr Pro Val  Phe Pro Phe 
    3155                 3160                 3165             


Ile Leu  Ala Asp Tyr Val Ser  Glu Thr Leu Asp Leu  Asn Asp Leu 
    3170                 3175                 3180             


Leu Ile  Tyr Arg Asn Leu Ser  Lys Pro Ile Ala Val  Gln Tyr Lys 
    3185                 3190                 3195             


Glu Lys  Glu Asp Arg Tyr Val  Asp Thr Tyr Lys Tyr  Leu Glu Glu 
    3200                 3205                 3210             


Glu Tyr  Arg Lys Gly Ala Arg  Glu Asp Asp Pro Met  Pro Pro Val 
    3215                 3220                 3225             


Gln Pro  Tyr His Tyr Gly Ser  His Tyr Ser Asn Ser  Gly Thr Val 
    3230                 3235                 3240             


Leu His  Phe Leu Val Arg Met  Pro Pro Phe Thr Lys  Met Phe Leu 
    3245                 3250                 3255             


Ala Tyr  Gln Asp Gln Ser Phe  Asp Ile Pro Asp Arg  Thr Phe His 
    3260                 3265                 3270             


Ser Thr  Asn Thr Thr Trp Arg  Leu Ser Ser Phe Glu  Ser Met Thr 
    3275                 3280                 3285             


Asp Val  Lys Glu Leu Ile Pro  Glu Phe Phe Tyr Leu  Pro Glu Phe 
    3290                 3295                 3300             


Leu Val  Asn Arg Glu Gly Phe  Asp Phe Gly Val Arg  Gln Asn Gly 
    3305                 3310                 3315             


Glu Arg  Val Asn His Val Asn  Leu Pro Pro Trp Ala  Arg Asn Asp 
    3320                 3325                 3330             


Pro Arg  Leu Phe Ile Leu Ile  His Arg Gln Ala Leu  Glu Ser Asp 
    3335                 3340                 3345             


Tyr Val  Ser Gln Asn Ile Cys  Gln Trp Ile Asp Leu  Val Phe Gly 
    3350                 3355                 3360             


Tyr Lys  Gln Lys Gly Lys Ala  Ser Val Gln Ala Ile  Asn Val Phe 
    3365                 3370                 3375             


His Pro  Ala Thr Tyr Phe Gly  Met Asp Val Ser Ala  Val Glu Asp 
    3380                 3385                 3390             


Pro Val  Gln Arg Arg Ala Leu  Glu Thr Met Ile Lys  Thr Tyr Gly 
    3395                 3400                 3405             


Gln Thr  Pro Arg Gln Leu Phe  His Met Ala His Val  Ser Arg Pro 
    3410                 3415                 3420             


Gly Ala  Lys Leu Asn Ile Glu  Gly Glu Leu Pro Ala  Ala Val Gly 
    3425                 3430                 3435             


Leu Leu  Val Gln Phe Ala Phe  Arg Glu Thr Arg Glu  Gln Val Lys 
    3440                 3445                 3450             


Glu Ile  Thr Tyr Pro Ser Pro  Leu Ser Trp Ile Lys  Gly Leu Lys 
    3455                 3460                 3465             


Trp Gly  Glu Tyr Val Gly Ser  Pro Ser Ala Pro Val  Pro Val Val 
    3470                 3475                 3480             


Cys Phe  Ser Gln Pro His Gly  Glu Arg Phe Gly Ser  Leu Gln Ala 
    3485                 3490                 3495             


Leu Pro  Thr Arg Ala Ile Cys  Gly Leu Ser Arg Asn  Phe Cys Leu 
    3500                 3505                 3510             


Leu Met  Thr Tyr Ser Lys Glu  Gln Gly Val Arg Ser  Met Asn Ser 
    3515                 3520                 3525             


Thr Asp  Ile Gln Trp Ser Ala  Ile Leu Ser Trp Gly  Tyr Ala Asp 
    3530                 3535                 3540             


Asn Ile  Leu Arg Leu Lys Ser  Lys Gln Ser Glu Pro  Pro Val Asn 
    3545                 3550                 3555             


Phe Ile  Gln Ser Ser Gln Gln  Tyr Gln Val Thr Ser  Cys Ala Trp 
    3560                 3565                 3570             


Val Pro  Asp Ser Cys Gln Leu  Phe Thr Gly Ser Lys  Cys Gly Val 
    3575                 3580                 3585             


Ile Thr  Ala Tyr Thr Asn Arg  Phe Thr Ser Ser Thr  Pro Ser Glu 
    3590                 3595                 3600             


Ile Glu  Met Glu Thr Gln Ile  His Leu Tyr Gly His  Thr Glu Glu 
    3605                 3610                 3615             


Ile Thr  Ser Leu Phe Val Cys  Lys Pro Tyr Ser Ile  Leu Ile Ser 
    3620                 3625                 3630             


Val Ser  Arg Asp Gly Thr Cys  Ile Ile Trp Asp Leu  Asn Arg Leu 
    3635                 3640                 3645             


Cys Tyr  Val Gln Ser Leu Ala  Gly His Lys Ser Pro  Val Thr Ala 
    3650                 3655                 3660             


Val Ser  Ala Ser Glu Thr Ser  Gly Asp Ile Ala Thr  Val Cys Asp 
    3665                 3670                 3675             


Ser Ala  Gly Gly Gly Ser Asp  Leu Arg Leu Trp Thr  Val Asn Gly 
    3680                 3685                 3690             


Asp Leu  Val Gly His Val His  Cys Arg Glu Ile Ile  Cys Ser Val 
    3695                 3700                 3705             


Ala Phe  Ser Asn Gln Pro Glu  Gly Val Ser Ile Asn  Val Ile Ala 
    3710                 3715                 3720             


Gly Gly  Leu Glu Asn Gly Ile  Val Arg Leu Trp Ser  Thr Trp Asp 
    3725                 3730                 3735             


Leu Lys  Pro Val Arg Glu Ile  Thr Phe Pro Lys Ser  Asn Lys Pro 
    3740                 3745                 3750             


Ile Ile  Ser Leu Thr Phe Ser  Cys Asp Gly His His  Leu Tyr Thr 
    3755                 3760                 3765             


Ala Asn  Ser Asp Gly Thr Val  Ile Ala Trp Cys Arg  Lys Asp Gln 
    3770                 3775                 3780             


Gln Arg  Leu Lys Gln Pro Met  Phe Tyr Ser Phe Leu  Ser Ser Tyr 
    3785                 3790                 3795             


Ala Ala  Gly 
    3800     


<210>  775
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  775

Met Val Leu Pro Thr Cys Pro Met Ala Glu Phe Ala Leu Pro Arg His 
1               5                   10                  15      


Ser Ala Val Met Glu Arg Leu Arg Arg Arg Ile Glu Leu Cys Arg Arg 
            20                  25                  30          


His His Ser Thr Cys Glu Ala Arg Tyr Glu Ala Val Ser Pro Glu Arg 
        35                  40                  45              


Leu Glu Leu Glu Arg Gln His Thr Phe Ala Leu His Gln Arg Cys Ile 
    50                  55                  60                  


Gln Ala Lys Ala Lys Arg Ala Gly Lys His Arg Gln Pro Pro Ala Ala 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Pro Ala Pro Arg Leu Asp Ala Ala Asp 
                85                  90                  95      


Gly Pro Glu His Gly Arg Pro Ala Thr His Leu His Asp Thr Val Lys 
            100                 105                 110         


Arg Asn Leu Asp Ser Ala Thr Ser Pro Gln Asn Gly Asp Gln Gln Asn 
        115                 120                 125             


Gly Tyr Gly Asp Leu Phe Pro Gly His Lys Lys Thr Arg Arg Glu Ala 
    130                 135                 140                 


Pro Leu Gly Val Ala Ile Ser Ser Asn Gly Leu Pro Pro Ala Ser Pro 
145                 150                 155                 160 


Leu Gly Gln Ser Asp Lys Pro Ser Gly Ala Asp Ala Leu Gln Ser Ser 
                165                 170                 175     


Gly Lys His Ser Leu Gly Leu Asp Ser Leu Asn Lys Lys Arg Leu Ala 
            180                 185                 190         


Asp Ser Ser Leu His Leu Asn Gly Gly Ser Asn Pro Ser Glu Ser Phe 
        195                 200                 205             


Pro Leu Ser Leu Asn Lys Glu Leu Lys Gln Glu Pro Val Glu Asp Leu 
    210                 215                 220                 


Pro Cys Met Ile Thr Gly Thr Val Gly Ser Ile Ser Gln Ser Asn Leu 
225                 230                 235                 240 


Met Pro Asp Leu Asn Leu Asn Glu Gln Glu Trp Lys Glu Leu Ile Glu 
                245                 250                 255     


Glu Leu Asn Arg Ser Val Pro Asp Glu Asp Met Lys Asp Leu Phe Asn 
            260                 265                 270         


Glu Asp Phe Glu Glu Lys Lys Asp Pro Glu Ser Ser Gly Ser Ala Thr 
        275                 280                 285             


Gln Thr Pro Leu Ala Gln Asp Ile Asn Ile Lys Thr Glu Phe Ser Pro 
    290                 295                 300                 


Ala Ala Phe Glu Gln Glu Gln Leu Gly Ser Pro Gln Val Arg Ala Gly 
305                 310                 315                 320 


Ser Ala Gly Gln Thr Phe Leu Gly Pro Ser Ser Ala Pro Val Ser Thr 
                325                 330                 335     


Asp Ser Pro Ser Leu Gly Gly Ser Gln Thr Leu Phe His Thr Ser Gly 
            340                 345                 350         


Gln Pro Arg Ala Asp Asn Pro Ser Pro Asn Leu Met Pro Ala Ser Ala 
        355                 360                 365             


Gln Ala Gln Asn Ala Gln Arg Ala Leu Ala Gly Val Val Leu Pro Ser 
    370                 375                 380                 


Gln Gly Pro Gly Gly Ala Ser Glu Leu Ser Ser Ala His Gln Leu Gln 
385                 390                 395                 400 


Gln Ile Ala Ala Lys Gln Lys Arg Glu Gln Met Leu Gln Asn Pro Gln 
                405                 410                 415     


Gln Ala Thr Pro Ala Pro Ala Pro Gly Gln Met Ser Thr Trp Gln Gln 
            420                 425                 430         


Thr Gly Pro Ser His Ser Ser Leu Asp Val Pro Tyr Pro Met Glu Lys 
        435                 440                 445             


Pro Ala Ser Pro Ser Ser Tyr Lys Gln Asp Phe Thr Asn Ser Lys Leu 
    450                 455                 460                 


Leu Met Met Pro Ser Val Asn Lys Ser Ser Pro Arg Pro Gly Gly Pro 
465                 470                 475                 480 


Tyr Leu Gln Pro Ser His Val Asn Leu Leu Ser His Gln Pro Pro Ser 
                485                 490                 495     


Asn Leu Asn Gln Asn Ser Ala Asn Asn Gln Gly Ser Val Leu Asp Tyr 
            500                 505                 510         


Gly Asn Thr Lys Pro Leu Ser His Tyr Lys Ala Asp Cys Gly Gln Gly 
        515                 520                 525             


Ser Pro Gly Ser Gly Gln Ser Lys Pro Ala Leu Met Ala Tyr Leu Pro 
    530                 535                 540                 


Gln Gln Leu Ser His Ile Ser His Glu Gln Asn Ser Leu Phe Leu Met 
545                 550                 555                 560 


Lys Pro Lys Pro Gly Asn Met Pro Phe Arg Ser Leu Val Pro Pro Gly 
                565                 570                 575     


Gln Glu Gln Asn Pro Ser Ser Val Pro Val Gln Ala Gln Ala Thr Ser 
            580                 585                 590         


Val Gly Thr Gln Pro Pro Ala Val Ser Val Ala Ser Ser His Asn Ser 
        595                 600                 605             


Ser Pro Tyr Leu Ser Ser Gln Gln Gln Ala Ala Val Met Lys Gln His 
    610                 615                 620                 


Gln Leu Leu Leu Asp Gln Gln Lys Gln Arg Glu Gln Gln Gln Lys His 
625                 630                 635                 640 


Leu Gln Gln Gln Gln Phe Leu Gln Arg Gln Gln His Leu Leu Ala Glu 
                645                 650                 655     


Gln Glu Lys Gln Gln Phe Gln Arg His Leu Thr Arg Pro Pro Pro Gln 
            660                 665                 670         


Tyr Gln Asp Pro Thr Gln Gly Ser Phe Pro Gln Gln Val Gly Gln Phe 
        675                 680                 685             


Thr Gly Ser Ser Ala Ala Val Pro Gly Met Asn Thr Leu Gly Pro Ser 
    690                 695                 700                 


Asn Ser Ser Cys Pro Arg Val Phe Pro Gln Ala Gly Asn Leu Met Pro 
705                 710                 715                 720 


Met Gly Pro Gly His Ala Ser Val Ser Ser Leu Pro Thr Asn Ser Gly 
                725                 730                 735     


Gln Gln Asp Arg Gly Val Ala Gln Phe Pro Gly Ser Gln Asn Met Pro 
            740                 745                 750         


Gln Ser Ser Leu Tyr Gly Met Ala Ser Gly Ile Thr Gln Ile Val Ala 
        755                 760                 765             


Gln Pro Pro Pro Gln Ala Thr Asn Gly His Ala His Ile Pro Arg Gln 
    770                 775                 780                 


Thr Asn Val Gly Gln Asn Thr Ser Val Ser Ala Ala Tyr Gly Gln Asn 
785                 790                 795                 800 


Ser Leu Gly Ser Ser Gly Leu Ser Gln Gln His Asn Lys Gly Thr Leu 
                805                 810                 815     


Asn Pro Gly Leu Thr Lys Pro Pro Val Pro Arg Val Ser Pro Ala Met 
            820                 825                 830         


Gly Gly Gln Asn Ser Ser Trp Gln His Gln Gly Met Pro Asn Leu Ser 
        835                 840                 845             


Gly Gln Thr Pro Gly Asn Ser Asn Val Ser Pro Phe Thr Ala Ala Ser 
    850                 855                 860                 


Ser Phe His Met Gln Gln Gln Ala His Leu Lys Met Ser Ser Pro Gln 
865                 870                 875                 880 


Phe Ser Gln Ala Val Pro Asn Arg Pro Met Ala Pro Met Ser Ser Ala 
                885                 890                 895     


Ala Ala Val Gly Ser Leu Leu Pro Pro Val Ser Ala Gln Gln Arg Thr 
            900                 905                 910         


Ser Ala Pro Ala Pro Ala Pro Pro Pro Thr Ala Pro Gln Gln Gly Leu 
        915                 920                 925             


Pro Gly Leu Ser Pro Ala Gly Pro Glu Leu Gly Ala Phe Ser Gln Ser 
    930                 935                 940                 


Pro Ala Ser Gln Met Gly Gly Arg Ala Gly Leu His Cys Thr Gln Ala 
945                 950                 955                 960 


Tyr Pro Val Arg Thr Ala Gly Gln Glu Leu Pro Phe Ala Tyr Ser Gly 
                965                 970                 975     


Gln Pro Gly Gly Ser Gly Leu Ser Ser Val Ala Gly His Thr Asp Leu 
            980                 985                 990         


Ile Asp Ser Leu Leu Lys Asn Arg  Thr Ser Glu Glu Trp  Met Ser Asp 
        995                 1000                 1005             


Leu Asp  Asp Leu Leu Gly Ser  Gln 
    1010                 1015     


<210>  776
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  776

Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Val Ile Ile 
1               5                   10                  15      


Cys Phe Leu Thr Leu Arg Leu Ser Ala Ser Gln Asn Cys Leu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Val Val Ile Asp Ile Gln Ser Ser Leu Ser Lys Gly 
        35                  40                  45              


Ile Arg Gly Asn Glu Pro Val Tyr Thr Ser Thr Gln Glu Asp Cys Ile 
    50                  55                  60                  


Asn Ser Cys Cys Ser Thr Lys Asn Ile Ser Gly Asp Lys Ala Cys Asn 
65                  70                  75                  80  


Leu Met Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr 
                85                  90                  95      


Leu Phe Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys 
            100                 105                 110         


Gly Leu Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg 
        115                 120                 125             


Asn Leu Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly 
    130                 135                 140                 


Gln Phe Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr 
145                 150                 155                 160 


Ser Lys Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe 
                165                 170                 175     


Gly Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser 
            180                 185                 190         


Ala Gln Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln 
        195                 200                 205             


Phe Ser Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser 
    210                 215                 220                 


Ala Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala 
225                 230                 235                 240 


Thr Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro 
                245                 250                 255     


Ser Gly Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr 
            260                 265                 270         


Thr Val Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr 
        275                 280                 285             


Arg Ala Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr 
    290                 295                 300                 


Thr Thr Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile 
305                 310                 315                 320 


Pro Phe Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr 
                325                 330                 335     


Asn Pro Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn 
            340                 345                 350         


Lys Thr Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser 
        355                 360                 365             


Gln Gly Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp 
    370                 375                 380                 


Leu Leu Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly 
385                 390                 395                 400 


Leu Val Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg 
                405                 410                 415     


Tyr Ser Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
            420                 425                 430     


<210>  777
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  777

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


<210>  778
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  778

Met Glu Pro Leu Lys Ser Leu Phe Leu Lys Ser Pro Leu Gly Ser Trp 
1               5                   10                  15      


Asn Gly Ser Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Pro 
            20                  25                  30          


Glu Gly Ser Pro Lys Ala Ala Gly Tyr Ala Asn Pro Val Trp Thr Ala 
        35                  40                  45              


Leu Phe Asp Tyr Glu Pro Ser Gly Gln Asp Glu Leu Ala Leu Arg Lys 
    50                  55                  60                  


Gly Asp Arg Val Glu Val Leu Ser Arg Asp Ala Ala Ile Ser Gly Asp 
65                  70                  75                  80  


Glu Gly Trp Trp Ala Gly Gln Val Gly Gly Gln Val Gly Ile Phe Pro 
                85                  90                  95      


Ser Asn Tyr Val Ser Arg Gly Gly Gly Pro Pro Pro Cys Glu Val Ala 
            100                 105                 110         


Ser Phe Gln Glu Leu Arg Leu Glu Glu Val Ile Gly Ile Gly Gly Phe 
        115                 120                 125             


Gly Lys Val Tyr Arg Gly Ser Trp Arg Gly Glu Leu Val Ala Val Lys 
    130                 135                 140                 


Ala Ala Arg Gln Asp Pro Asp Glu Asp Ile Ser Val Thr Ala Glu Ser 
145                 150                 155                 160 


Val Arg Gln Glu Ala Arg Leu Phe Ala Met Leu Ala His Pro Asn Ile 
                165                 170                 175     


Ile Ala Leu Lys Ala Val Cys Leu Glu Glu Pro Asn Leu Cys Leu Val 
            180                 185                 190         


Met Glu Tyr Ala Ala Gly Gly Pro Leu Ser Arg Ala Leu Ala Gly Arg 
        195                 200                 205             


Arg Val Pro Pro His Val Leu Val Asn Trp Ala Val Gln Ile Ala Arg 
    210                 215                 220                 


Gly Met His Tyr Leu His Cys Glu Ala Leu Val Pro Val Ile His Arg 
225                 230                 235                 240 


Asp Leu Lys Ser Asn Asn Ile Leu Leu Leu Gln Pro Ile Glu Ser Asp 
                245                 250                 255     


Asp Met Glu His Lys Thr Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg 
            260                 265                 270         


Glu Trp His Lys Thr Thr Gln Met Ser Ala Ala Gly Thr Tyr Ala Trp 
        275                 280                 285             


Met Ala Pro Glu Val Ile Lys Ala Ser Thr Phe Ser Lys Gly Ser Asp 
    290                 295                 300                 


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val 
305                 310                 315                 320 


Pro Tyr Arg Gly Ile Asp Cys Leu Ala Val Ala Tyr Gly Val Ala Val 
                325                 330                 335     


Asn Lys Leu Thr Leu Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala 
            340                 345                 350         


Gln Leu Met Ala Asp Cys Trp Ala Gln Asp Pro His Arg Arg Pro Asp 
        355                 360                 365             


Phe Ala Ser Ile Leu Gln Gln Leu Glu Ala Leu Glu Ala Gln Val Leu 
    370                 375                 380                 


Arg Glu Met Pro Arg Asp Ser Phe His Ser Met Gln Glu Gly Trp Lys 
385                 390                 395                 400 


Arg Glu Ile Gln Gly Leu Phe Asp Glu Leu Arg Ala Lys Glu Lys Glu 
                405                 410                 415     


Leu Leu Ser Arg Glu Glu Glu Leu Thr Arg Ala Ala Arg Glu Gln Arg 
            420                 425                 430         


Ser Gln Ala Glu Gln Leu Arg Arg Arg Glu His Leu Leu Ala Gln Trp 
        435                 440                 445             


Glu Leu Glu Val Phe Glu Arg Glu Leu Thr Leu Leu Leu Gln Gln Val 
    450                 455                 460                 


Asp Arg Glu Arg Pro His Val Arg Arg Arg Arg Gly Thr Phe Lys Arg 
465                 470                 475                 480 


Ser Lys Leu Arg Ala Arg Asp Gly Gly Glu Arg Ile Ser Met Pro Leu 
                485                 490                 495     


Asp Phe Lys His Arg Ile Thr Val Gln Ala Ser Pro Gly Leu Asp Arg 
            500                 505                 510         


Arg Arg Asn Val Phe Glu Val Gly Pro Gly Asp Ser Pro Thr Phe Pro 
        515                 520                 525             


Arg Phe Arg Ala Ile Gln Leu Glu Pro Ala Glu Pro Gly Gln Ala Trp 
    530                 535                 540                 


Gly Arg Gln Ser Pro Arg Arg Leu Glu Asp Ser Ser Asn Gly Glu Arg 
545                 550                 555                 560 


Arg Ala Cys Trp Ala Trp Gly Pro Ser Ser Pro Lys Pro Gly Glu Ala 
                565                 570                 575     


Gln Asn Gly Arg Arg Arg Ser Arg Met Asp Glu Ala Thr Trp Tyr Leu 
            580                 585                 590         


Asp Ser Asp Asp Ser Ser Pro Leu Gly Ser Pro Ser Thr Pro Pro Ala 
        595                 600                 605             


Leu Asn Gly Asn Pro Pro Arg Pro Ser Leu Glu Pro Glu Glu Pro Lys 
    610                 615                 620                 


Arg Pro Val Pro Ala Glu Arg Gly Ser Ser Ser Gly Thr Pro Lys Leu 
625                 630                 635                 640 


Ile Gln Arg Ala Leu Leu Arg Gly Thr Ala Leu Leu Ala Ser Leu Gly 
                645                 650                 655     


Leu Gly Arg Asp Leu Gln Pro Pro Gly Gly Pro Gly Arg Glu Arg Gly 
            660                 665                 670         


Glu Ser Pro Thr Thr Pro Pro Thr Pro Thr Pro Ala Pro Cys Pro Thr 
        675                 680                 685             


Glu Pro Pro Pro Ser Pro Leu Ile Cys Phe Ser Leu Lys Thr Pro Asp 
    690                 695                 700                 


Ser Pro Pro Thr Pro Ala Pro Leu Leu Leu Asp Leu Gly Ile Pro Val 
705                 710                 715                 720 


Gly Gln Arg Ser Ala Lys Ser Pro Arg Arg Glu Glu Glu Pro Arg Gly 
                725                 730                 735     


Gly Thr Val Ser Pro Pro Pro Gly Thr Ser Arg Ser Ala Pro Gly Thr 
            740                 745                 750         


Pro Gly Thr Pro Arg Ser Pro Pro Leu Gly Leu Ile Ser Arg Pro Arg 
        755                 760                 765             


Pro Ser Pro Leu Arg Ser Arg Ile Asp Pro Trp Ser Phe Val Ser Ala 
    770                 775                 780                 


Gly Pro Arg Pro Ser Pro Leu Pro Ser Pro Gln Pro Ala Pro Arg Arg 
785                 790                 795                 800 


Ala Pro Trp Thr Leu Phe Pro Asp Ser Asp Pro Phe Trp Asp Ser Pro 
                805                 810                 815     


Pro Ala Asn Pro Phe Gln Gly Gly Pro Gln Asp Cys Arg Ala Gln Thr 
            820                 825                 830         


Lys Asp Met Gly Ala Gln Ala Pro Trp Val Pro Glu Ala Gly Pro 
        835                 840                 845         


<210>  779
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  779

Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala 
1               5                   10                  15      


Leu Gln Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys 
            20                  25                  30          


Asn Lys Asp Thr Gly His Ser Asn Arg Gln Ser Asp Val Arg Ile Lys 
        35                  40                  45              


Phe Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val 
    50                  55                  60                  


Lys Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro 
65                  70                  75                  80  


Leu Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn 
                85                  90                  95      


Gln Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser 
            100                 105                 110         


Met Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Asn 
        115                 120                 125             


Ser Ser Ser Pro His Ser Gly Val Ser Arg Gln Val Arg Ile Lys Ala 
    130                 135                 140                 


Ser Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro 
145                 150                 155                 160 


Arg Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser 
                165                 170                 175     


Pro Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln 
            180                 185                 190         


Gly Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr 
        195                 200                 205             


Ser Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu 
    210                 215                 220                 


Ser Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe 
225                 230                 235                 240 


Arg Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro Asp Asn Arg Gln 
                245                 250                 255     


Glu Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly 
            260                 265                 270         


Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr 
        275                 280                 285             


Ser Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn 
    290                 295                 300                 


Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu 
305                 310                 315                 320 


Asn Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg 
                325                 330                 335     


Ser Ala Asp Ser Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro 
            340                 345                 350         


Thr Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu 
        355                 360                 365             


Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr 
    370                 375                 380                 


Gly Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro 
385                 390                 395                 400 


Glu Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu 
                405                 410                 415     


Lys Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg 
            420                 425                 430         


Asp Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro Gly 
        435                 440                 445             


Gly Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser 
    450                 455                 460                 


Val Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu 
465                 470                 475                 480 


His Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu 
                485                 490                 495     


Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys 
            500                 505                 510         


Arg Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr 
        515                 520                 525             


Gly Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr 
    530                 535                 540                 


Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met 
545                 550                 555                 560 


Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile 
                565                 570                 575     


Phe Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile 
            580                 585                 590         


Ser Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg 
        595                 600                 605             


Gln Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu 
    610                 615                 620                 


Met Tyr 
625     


<210>  780
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Ser Thr Glu Ala Asp Glu Gly Ile Thr Phe Ser Val Pro Pro Phe 
1               5                   10                  15      


Ala Pro Ser Gly Phe Cys Thr Ile Pro Glu Gly Gly Ile Cys Arg Arg 
            20                  25                  30          


Gly Gly Ala Ala Ala Val Gly Glu Gly Glu Glu His Gln Leu Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly Ser Phe Trp Asn Val Glu Ser Ala Ala Ala Pro Gly 
    50                  55                  60                  


Ile Gly Cys Pro Ala Ala Thr Ser Ser Ser Ser Ala Thr Arg Gly Arg 
65                  70                  75                  80  


Gly Ser Ser Val Gly Gly Gly Ser Arg Arg Thr Thr Val Ala Tyr Val 
                85                  90                  95      


Ile Asn Glu Ala Ser Gln Gly Gln Leu Val Val Ala Glu Ser Glu Ala 
            100                 105                 110         


Leu Gln Ser Leu Arg Glu Ala Cys Glu Thr Val Gly Ala Thr Leu Glu 
        115                 120                 125             


Thr Leu His Phe Gly Lys Leu Asp Phe Gly Glu Thr Thr Val Leu Asp 
    130                 135                 140                 


Arg Phe Tyr Asn Ala Asp Ile Ala Val Val Glu Met Ser Asp Ala Phe 
145                 150                 155                 160 


Arg Gln Pro Ser Leu Phe Tyr His Leu Gly Val Arg Glu Ser Phe Ser 
                165                 170                 175     


Met Ala Asn Asn Ile Ile Leu Tyr Cys Asp Thr Asn Ser Asp Ser Leu 
            180                 185                 190         


Gln Ser Leu Lys Glu Ile Ile Cys Gln Lys Asn Thr Met Cys Thr Gly 
        195                 200                 205             


Asn Tyr Thr Phe Val Pro Tyr Met Ile Thr Pro His Asn Lys Val Tyr 
    210                 215                 220                 


Cys Cys Asp Ser Ser Phe Met Lys Gly Leu Thr Glu Leu Met Gln Pro 
225                 230                 235                 240 


Asn Phe Glu Leu Leu Leu Gly Pro Ile Cys Leu Pro Leu Val Asp Arg 
                245                 250                 255     


Phe Ile Gln Leu Leu Lys Val Ala Gln Ala Ser Ser Ser Gln Tyr Phe 
            260                 265                 270         


Arg Glu Ser Ile Leu Asn Asp Ile Arg Lys Ala Arg Asn Leu Tyr Thr 
        275                 280                 285             


Gly Lys Glu Leu Ala Ala Glu Leu Ala Arg Ile Arg Gln Arg Val Asp 
    290                 295                 300                 


Asn Ile Glu Val Leu Thr Ala Asp Ile Val Ile Asn Leu Leu Leu Ser 
305                 310                 315                 320 


Tyr Arg Asp Ile Gln Asp Tyr Asp Ser Ile Val Lys Leu Val Glu Thr 
                325                 330                 335     


Leu Glu Lys Leu Pro Thr Phe Asp Leu Ala Ser His His His Val Lys 
            340                 345                 350         


Phe His Tyr Ala Phe Ala Leu Asn Arg Arg Asn Leu Pro Gly Asp Arg 
        355                 360                 365             


Ala Lys Ala Leu Asp Ile Met Ile Pro Met Val Gln Ser Glu Gly Gln 
    370                 375                 380                 


Val Ala Ser Asp Met Tyr Cys Leu Val Gly Arg Ile Tyr Lys Asp Met 
385                 390                 395                 400 


Phe Leu Asp Ser Asn Phe Thr Asp Thr Glu Ser Arg Asp His Gly Ala 
                405                 410                 415     


Ser Trp Phe Lys Lys Ala Phe Glu Ser Glu Pro Thr Leu Gln Ser Gly 
            420                 425                 430         


Ile Asn Tyr Ala Val Leu Leu Leu Ala Ala Gly His Gln Phe Glu Ser 
        435                 440                 445             


Ser Phe Glu Leu Arg Lys Val Gly Val Lys Leu Ser Ser Leu Leu Gly 
    450                 455                 460                 


Lys Lys Gly Asn Leu Glu Lys Leu Gln Ser Tyr Trp Glu Val Gly Phe 
465                 470                 475                 480 


Phe Leu Gly Ala Ser Val Leu Ala Asn Asp His Met Arg Val Ile Gln 
                485                 490                 495     


Ala Ser Glu Lys Leu Phe Lys Leu Lys Thr Pro Ala Trp Tyr Leu Lys 
            500                 505                 510         


Ser Ile Val Glu Thr Ile Leu Ile Tyr Lys His Phe Val Lys Leu Thr 
        515                 520                 525             


Thr Glu Gln Pro Val Ala Lys Gln Glu Leu Val Asp Phe Trp Met Asp 
    530                 535                 540                 


Phe Leu Val Glu Ala Thr Lys Thr Asp Val Thr Val Val Arg Phe Pro 
545                 550                 555                 560 


Val Leu Ile Leu Glu Pro Thr Lys Ile Tyr Gln Pro Ser Tyr Leu Ser 
                565                 570                 575     


Ile Asn Asn Glu Val Glu Glu Lys Thr Ile Ser Ile Trp His Val Leu 
            580                 585                 590         


Pro Asp Asp Lys Lys Gly Ile His Glu Trp Asn Phe Ser Ala Ser Ser 
        595                 600                 605             


Val Arg Gly Val Ser Ile Ser Lys Phe Glu Glu Arg Cys Cys Phe Leu 
    610                 615                 620                 


Tyr Val Leu His Asn Ser Asp Asp Phe Gln Ile Tyr Phe Cys Thr Glu 
625                 630                 635                 640 


Leu His Cys Lys Lys Phe Phe Glu Met Val Asn Thr Ile Thr Glu Glu 
                645                 650                 655     


Lys Gly Arg Ser Thr Glu Glu Gly Asp Cys Glu Ser Asp Leu Leu Glu 
            660                 665                 670         


Tyr Asp Tyr Glu Tyr Asp Glu Asn Gly Asp Arg Val Val Leu Gly Lys 
        675                 680                 685             


Gly Thr Tyr Gly Ile Val Tyr Ala Gly Arg Asp Leu Ser Asn Gln Val 
    690                 695                 700                 


Arg Ile Ala Ile Lys Glu Ile Pro Glu Arg Asp Ser Arg Tyr Ser Gln 
705                 710                 715                 720 


Pro Leu His Glu Glu Ile Ala Leu His Lys His Leu Lys His Lys Asn 
                725                 730                 735     


Ile Val Gln Tyr Leu Gly Ser Phe Ser Glu Asn Gly Phe Ile Lys Ile 
            740                 745                 750         


Phe Met Glu Gln Val Pro Gly Gly Ser Leu Ser Ala Leu Leu Arg Ser 
        755                 760                 765             


Lys Trp Gly Pro Leu Lys Asp Asn Glu Gln Thr Ile Gly Phe Tyr Thr 
    770                 775                 780                 


Lys Gln Ile Leu Glu Gly Leu Lys Tyr Leu His Asp Asn Gln Ile Val 
785                 790                 795                 800 


His Arg Asp Ile Lys Gly Asp Asn Val Leu Ile Asn Thr Tyr Ser Gly 
                805                 810                 815     


Val Leu Lys Ile Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala Gly Ile 
            820                 825                 830         


Asn Pro Cys Thr Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met Ala Pro 
        835                 840                 845             


Glu Ile Ile Asp Lys Gly Pro Arg Gly Tyr Gly Lys Ala Ala Asp Ile 
    850                 855                 860                 


Trp Ser Leu Gly Cys Thr Ile Ile Glu Met Ala Thr Gly Lys Pro Pro 
865                 870                 875                 880 


Phe Tyr Glu Leu Gly Glu Pro Gln Ala Ala Met Phe Lys Val Gly Met 
                885                 890                 895     


Phe Lys Val His Pro Glu Ile Pro Glu Ser Met Ser Ala Glu Ala Lys 
            900                 905                 910         


Ala Phe Ile Leu Lys Cys Phe Glu Pro Asp Pro Asp Lys Arg Ala Cys 
        915                 920                 925             


Ala Asn Asp Leu Leu Val Asp Glu Phe Leu Lys Val Ser Ser Lys Lys 
    930                 935                 940                 


Lys Lys Thr Gln Pro Lys Leu Ser Ala Leu Ser Ala Gly Ser Asn Glu 
945                 950                 955                 960 


Tyr Leu Arg Ser Ile Ser Leu Pro Val Pro Val Leu Val Glu Asp Thr 
                965                 970                 975     


Ser Ser Ser Ser Glu Tyr Gly Ser Val Ser Pro Asp Thr Glu Leu Lys 
            980                 985                 990         


Val Asp Pro Phe Ser Phe Lys Thr  Arg Ala Lys Ser Cys  Gly Glu Arg 
        995                 1000                 1005             


Asp Val  Lys Gly Ile Arg Thr  Leu Phe Leu Gly Ile  Pro Asp Glu 
    1010                 1015                 1020             


Asn Phe  Glu Asp His Ser Ala  Pro Pro Ser Pro Glu  Glu Lys Asp 
    1025                 1030                 1035             


Ser Gly  Phe Phe Met Leu Arg  Lys Asp Ser Glu Arg  Arg Ala Thr 
    1040                 1045                 1050             


Leu His  Arg Ile Leu Thr Glu  Asp Gln Asp Lys Ile  Val Arg Asn 
    1055                 1060                 1065             


Leu Met  Glu Ser Leu Ala Gln  Gly Ala Glu Glu Pro  Lys Leu Lys 
    1070                 1075                 1080             


Trp Glu  His Ile Thr Thr Leu  Ile Ala Ser Leu Arg  Glu Phe Val 
    1085                 1090                 1095             


Arg Ser  Thr Asp Arg Lys Ile  Ile Ala Thr Thr Leu  Ser Lys Leu 
    1100                 1105                 1110             


Lys Leu  Glu Leu Asp Phe Asp  Ser His Gly Ile Ser  Gln Val Gln 
    1115                 1120                 1125             


Val Val  Leu Phe Gly Phe Gln  Asp Ala Val Asn Lys  Val Leu Arg 
    1130                 1135                 1140             


Asn His  Asn Ile Lys Pro His  Trp Met Phe Ala Leu  Asp Ser Ile 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Gln Thr  Ala Ile Thr Ile Leu  Val Pro Glu 
    1160                 1165                 1170             


Leu Arg  Pro His Phe Ser Leu  Ala Ser Glu Ser Asp  Thr Ala Asp 
    1175                 1180                 1185             


Gln Glu  Asp Leu Asp Val Glu  Asp Asp His Glu Glu  Gln Pro Ser 
    1190                 1195                 1200             


Asn Gln  Thr Val Arg Arg Pro  Gln Ala Val Ile Glu  Asp Ala Val 
    1205                 1210                 1215             


Ala Thr  Ser Gly Val Ser Thr  Leu Ser Ser Thr Val  Ser His Asp 
    1220                 1225                 1230             


Ser Gln  Ser Ala His Arg Ser  Leu Asn Val Gln Leu  Gly Arg Met 
    1235                 1240                 1245             


Lys Ile  Glu Thr Asn Arg Leu  Leu Glu Glu Leu Val  Arg Lys Glu 
    1250                 1255                 1260             


Lys Glu  Leu Gln Ala Leu Leu  His Arg Ala Ile Glu  Glu Lys Asp 
    1265                 1270                 1275             


Gln Glu  Ile Lys His Leu Lys  Leu Lys Ser Gln Pro  Ile Glu Ile 
    1280                 1285                 1290             


Pro Glu  Leu Pro Val Phe His  Leu Asn Ser Ser Gly  Thr Asn Thr 
    1295                 1300                 1305             


Glu Asp  Ser Glu Leu Thr Asp  Trp Leu Arg Val Asn  Gly Ala Asp 
    1310                 1315                 1320             


Glu Asp  Thr Ile Ser Arg Phe  Leu Ala Glu Asp Tyr  Thr Leu Leu 
    1325                 1330                 1335             


Asp Val  Leu Tyr Tyr Val Thr  Arg Asp Asp Leu Lys  Cys Leu Arg 
    1340                 1345                 1350             


Leu Arg  Gly Gly Met Leu Cys  Thr Leu Trp Lys Ala  Ile Ile Asp 
    1355                 1360                 1365             


Phe Arg  Asn Lys Gln Thr 
    1370                 


<210>  781
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  781

Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu His Asp 
                485                 490                 495     


His Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln 
            500                 505                 510         


Gln Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His 
        515                 520                 525             


Tyr Glu Pro Ala Asp Arg Ala Arg Glu Val Pro Val Arg Thr Thr Ser 
    530                 535                 540                 


Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly Ser Gly 
545                 550                 555                 560 


Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser Thr Ser Ile Glu Pro 
                565                 570                 575     


Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly Ser 
            580                 585                 590         


Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro Gly Ser His 
        595                 600                 605             


Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser Ser 
    610                 615                 620                 


Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn Ala Val Lys 
625                 630                 635                 640 


Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala Val 
                645                 650                 655     


Arg Ile Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu Asp 
            660                 665                 670         


Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu 
        675                 680                 685             


Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu Gly Ala 
    690                 695                 700                 


Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu 
705                 710                 715                 720 


Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile Val His 
                725                 730                 735     


Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly Thr 
            740                 745                 750         


Leu Ile Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln Lys His 
        755                 760                 765             


Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu Leu Gln 
    770                 775                 780                 


Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe Ser 
785                 790                 795                 800 


Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr Arg Lys 
                805                 810                 815     


Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln Ser Asp 
            820                 825                 830         


Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu 
        835                 840                 845             


Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser Gly 
    850                 855                 860                 


Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro Leu Ile 
865                 870                 875                 880 


Asn Arg Arg Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu Asn Val 
                885                 890                 895     


Leu Val Thr Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr Leu 
            900                 905                 910         


Ser Trp Leu Arg Asn Lys Ile Leu His Asn Asp Pro Glu Val Glu Lys 
        915                 920                 925             


Lys Gln Gly Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His Tyr 
    930                 935                 940                 


Lys Val Val Lys Tyr Glu Arg Ile Lys Phe Leu Val Ile Ala Leu Lys 
945                 950                 955                 960 


Ser Ser Val Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys Phe 
                965                 970                 975     


Met Ala Phe Lys Ser Phe Gly Glu Leu Val His Lys Pro Leu Leu Val 
            980                 985                 990         


Asp Leu Thr Val Glu Glu Gly Gln  Arg Leu Lys Val Ile  Tyr Gly Ser 
        995                 1000                 1005             


Cys Ala  Gly Phe His Ala Val  Asp Val Asp Ser Gly  Ser Val Tyr 
    1010                 1015                 1020             


Asp Ile  Tyr Leu Pro Thr His  Val Arg Lys Asn Pro  His Ser Met 
    1025                 1030                 1035             


Ile Gln  Cys Ser Ile Lys Pro  His Ala Ile Ile Ile  Leu Pro Asn 
    1040                 1045                 1050             


Thr Asp  Gly Met Glu Leu Leu  Val Cys Tyr Glu Asp  Glu Gly Val 
    1055                 1060                 1065             


Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys Asp Val  Val Leu Gln 
    1070                 1075                 1080             


Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr Ile Arg  Ser Asn Gln 
    1085                 1090                 1095             


Thr Met  Gly Trp Gly Glu Lys  Ala Ile Glu Ile Arg  Ser Val Glu 
    1100                 1105                 1110             


Thr Gly  His Leu Asp Gly Val  Phe Met His Lys Arg  Ala Gln Arg 
    1115                 1120                 1125             


Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys Val Phe  Phe Ala Ser 
    1130                 1135                 1140             


Val Arg  Ser Gly Gly Ser Ser  Gln Val Tyr Phe Met  Thr Leu Gly 
    1145                 1150                 1155             


Arg Thr  Ser Leu Leu Ser Trp  
    1160                 1165 


<210>  782
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  783
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  783

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asn Gln Leu Gln Gln Ile Met Arg Leu Thr Gly 
225                 230                 235                 240 


Thr Pro Pro Ala Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  784
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  784

Met Pro Gly Pro Thr Gln Thr Leu Ser Pro Asn Gly Glu Asn Asn Asn 
1               5                   10                  15      


Asp Ile Ile Gln Asp Asn Asn Gly Thr Ile Ile Pro Phe Arg Lys His 
            20                  25                  30          


Thr Val Arg Gly Glu Arg Ser Tyr Ser Trp Gly Met Ala Val Asn Val 
        35                  40                  45              


Tyr Ser Thr Ser Ile Thr Gln Glu Thr Met Ser Arg His Asp Ile Ile 
    50                  55                  60                  


Ala Trp Val Asn Asp Ile Val Ser Leu Asn Tyr Thr Lys Val Glu Gln 
65                  70                  75                  80  


Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met Asp Met Leu Phe Pro 
                85                  90                  95      


Gly Cys Ile Ser Leu Lys Lys Val Lys Phe Gln Ala Lys Leu Glu His 
            100                 105                 110         


Glu Tyr Ile His Asn Phe Lys Leu Leu Gln Ala Ser Phe Lys Arg Met 
        115                 120                 125             


Asn Val Asp Lys Val Ile Pro Val Glu Lys Leu Val Lys Gly Arg Phe 
    130                 135                 140                 


Gln Asp Asn Leu Asp Phe Ile Gln Trp Phe Lys Lys Phe Tyr Asp Ala 
145                 150                 155                 160 


Asn Tyr Asp Gly Lys Glu Tyr Asp Pro Val Glu Ala Arg Gln Gly Gln 
                165                 170                 175     


Asp Ala Ile Pro Pro Pro Asp Pro Gly Glu Gln Ile Phe Asn Leu Pro 
            180                 185                 190         


Lys Lys Ser His His Ala Asn Ser Pro Thr Ala Gly Ala Ala Lys Ser 
        195                 200                 205             


Ser Pro Ala Ala Lys Pro Gly Ser Thr Pro Ser Arg Pro Ser Ser Ala 
    210                 215                 220                 


Lys Arg Ala Ser Ser Ser Gly Ser Ala Ser Lys Ser Asp Lys Asp Leu 
225                 230                 235                 240 


Glu Thr Gln Val Ile Gln Leu Asn Glu Gln Val His Ser Leu Lys Leu 
                245                 250                 255     


Ala Leu Glu Gly Val Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu 
            260                 265                 270         


Arg Glu Ile Glu Leu Leu Cys Gln Glu His Gly Gln Glu Asn Asp Asp 
        275                 280                 285             


Leu Val Gln Arg Leu Met Asp Ile Leu Tyr Ala Ser Glu Glu His Glu 
    290                 295                 300                 


Gly His Thr Glu Glu Pro Glu Ala Glu Glu Gln Ala His Glu Gln Gln 
305                 310                 315                 320 


Pro Pro Gln Gln Glu Glu Tyr 
                325         


<210>  785
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  785

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  786
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15      


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30          


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45              


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60                  


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80  


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95      


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110         


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125             


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140                 


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160 


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175     


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190         


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205             


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220                 


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240 


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255     


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270         


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285             


Ile His Val 
    290     


<210>  787
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  787

Met Ser Thr Arg Thr Pro Leu Pro Thr Val Asn Glu Arg Asp Thr Glu 
1               5                   10                  15      


Asn His Thr Ser His Gly Asp Gly Arg Gln Glu Val Thr Ser Arg Thr 
            20                  25                  30          


Ser Arg Ser Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser Cys Ala Asp 
        35                  40                  45              


Glu Gln Pro His Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys 
    50                  55                  60                  


Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Arg 
65                  70                  75                  80  


Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn Pro Thr Ser 
                85                  90                  95      


Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Ile Leu Asn His 
            100                 105                 110         


Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu 
        115                 120                 125             


Tyr Leu Ile Met Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu 
    130                 135                 140                 


Val Ala His Gly Arg Met Lys Glu Lys Glu Ala Arg Ser Lys Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val Gln Tyr Cys His Gln Lys Arg Ile Val His 
                165                 170                 175     


Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile 
            180                 185                 190         


Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Val Gly Gly Lys 
        195                 200                 205             


Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe 
    210                 215                 220                 


Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly 
225                 230                 235                 240 


Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln 
                245                 250                 255     


Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile 
            260                 265                 270         


Pro Phe Tyr Met Ser Thr Asp Cys Glu Asn Leu Leu Lys Arg Phe Leu 
        275                 280                 285             


Val Leu Asn Pro Ile Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp 
    290                 295                 300                 


Arg Trp Ile Asn Ala Gly His Glu Glu Asp Glu Leu Lys Pro Phe Val 
305                 310                 315                 320 


Glu Pro Glu Leu Asp Ile Ser Asp Gln Lys Arg Ile Asp Ile Met Val 
                325                 330                 335     


Gly Met Gly Tyr Ser Gln Glu Glu Ile Gln Glu Ser Leu Ser Lys Met 
            340                 345                 350         


Lys Tyr Asp Glu Ile Thr Ala Thr Tyr Leu Leu Leu Gly Arg Lys Ser 
        355                 360                 365             


Ser Glu Leu Asp Ala Ser Asp Ser Ser Ser Ser Ser Asn Leu Ser Leu 
    370                 375                 380                 


Ala Lys Val Arg Pro Ser Ser Asp Leu Asn Asn Ser Thr Gly Gln Ser 
385                 390                 395                 400 


Pro His His Lys Val Gln Arg Ser Val Ser Ser Ser Gln Lys Gln Arg 
                405                 410                 415     


Arg Tyr Ser Asp His Ala Gly Pro Ala Ile Pro Ser Val Val Ala Tyr 
            420                 425                 430         


Pro Lys Arg Ser Gln Thr Ser Thr Ala Asp Ser Asp Leu Lys Glu Asp 
        435                 440                 445             


Gly Ile Ser Ser Arg Lys Ser Ser Gly Ser Ala Val Gly Gly Lys Gly 
    450                 455                 460                 


Ile Ala Pro Ala Ser Pro Met Leu Gly Asn Ala Ser Asn Pro Asn Lys 
465                 470                 475                 480 


Ala Asp Ile Pro Glu Arg Lys Lys Ser Ser Thr Val Pro Ser Ser Asn 
                485                 490                 495     


Thr Ala Ser Gly Gly Met Thr Arg Arg Asn Thr Tyr Val Cys Ser Glu 
            500                 505                 510         


Arg Thr Thr Ala Asp Arg His Ser Val Ile Gln Asn Gly Lys Glu Asn 
        515                 520                 525             


Ser Thr Ile Pro Asp Gln Arg Thr Pro Val Ala Ser Thr His Ser Ile 
    530                 535                 540                 


Ser Ser Ala Ala Thr Pro Asp Arg Ile Arg Phe Pro Arg Gly Thr Ala 
545                 550                 555                 560 


Ser Arg Ser Thr Phe His Gly Gln Pro Arg Glu Arg Arg Thr Ala Thr 
                565                 570                 575     


Tyr Asn Gly Pro Pro Ala Ser Pro Ser Leu Ser His Glu Ala Thr Pro 
            580                 585                 590         


Leu Ser Gln Thr Arg Ser Arg Gly Ser Thr Asn Leu Phe Ser Lys Leu 
        595                 600                 605             


Thr Ser Lys Leu Thr Arg Ser Arg Asn Val Ser Ala Glu Gln Lys Asp 
    610                 615                 620                 


Glu Asn Lys Glu Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met 
625                 630                 635                 640 


Lys Thr Thr Ser Ser Met Asp Pro Gly Asp Met Met Arg Glu Ile Arg 
                645                 650                 655     


Lys Val Leu Asp Ala Asn Asn Cys Asp Tyr Glu Gln Arg Glu Arg Phe 
            660                 665                 670         


Leu Leu Phe Cys Val His Gly Asp Gly His Ala Glu Asn Leu Val Gln 
        675                 680                 685             


Trp Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val 
    690                 695                 700                 


Arg Phe Lys Arg Ile Ser Gly Thr Ser Ile Ala Phe Lys Asn Ile Ala 
705                 710                 715                 720 


Ser Lys Ile Ala Asn Glu Leu Lys Leu 
                725                 


<210>  788
<211>  1309
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Asp Glu Ser Ser Leu Leu Arg Arg Arg Gly Leu Gln Lys Glu Leu 
1               5                   10                  15      


Ser Leu Pro Arg Arg Gly Arg Gly Cys Arg Ser Gly Asn Arg Lys Ser 
            20                  25                  30          


Leu Val Val Gly Thr Pro Ser Pro Thr Leu Ser Arg Pro Leu Ser Pro 
        35                  40                  45              


Leu Ser Val Pro Thr Ala Gly Ser Ser Pro Leu Asp Ser Pro Arg Asn 
    50                  55                  60                  


Phe Ser Ala Ala Ser Ala Leu Asn Phe Pro Phe Ala Arg Arg Ala Asp 
65                  70                  75                  80  


Gly Arg Arg Trp Ser Leu Ala Ser Leu Pro Ser Ser Gly Tyr Gly Thr 
                85                  90                  95      


Asn Thr Pro Ser Ser Thr Leu Ser Ser Ser Ser Ser Ser Arg Glu Arg 
            100                 105                 110         


Leu His Gln Leu Pro Phe Gln Pro Thr Pro Asp Glu Leu His Phe Leu 
        115                 120                 125             


Ser Lys His Phe Arg Ser Ser Glu Asn Val Leu Asp Glu Glu Gly Gly 
    130                 135                 140                 


Arg Ser Pro Arg Leu Arg Pro Arg Ser Arg Ser Leu Ser Pro Gly Arg 
145                 150                 155                 160 


Ala Thr Gly Thr Phe Asp Asn Glu Ile Val Met Met Asn His Val Tyr 
                165                 170                 175     


Arg Glu Arg Phe Pro Lys Ala Thr Ala Gln Met Glu Gly Arg Leu Gln 
            180                 185                 190         


Glu Phe Leu Thr Ala Tyr Ala Pro Gly Ala Arg Leu Ala Leu Ala Asp 
        195                 200                 205             


Gly Val Leu Gly Phe Ile His His Gln Ile Val Glu Leu Ala Arg Asp 
    210                 215                 220                 


Cys Leu Ala Lys Ser Gly Glu Asn Leu Val Thr Ser Arg Tyr Phe Leu 
225                 230                 235                 240 


Glu Met Gln Glu Lys Leu Glu Arg Leu Leu Gln Asp Ala His Glu Arg 
                245                 250                 255     


Ser Asp Ser Glu Glu Val Ser Phe Ile Val Gln Leu Val Arg Lys Leu 
            260                 265                 270         


Leu Ile Ile Ile Ser Arg Pro Ala Arg Leu Leu Glu Cys Leu Glu Phe 
        275                 280                 285             


Asp Pro Glu Glu Phe Tyr His Leu Leu Glu Ala Ala Glu Gly His Ala 
    290                 295                 300                 


Arg Glu Gly Gln Gly Ile Lys Thr Asp Leu Pro Gln Tyr Ile Ile Gly 
305                 310                 315                 320 


Gln Leu Gly Leu Ala Lys Asp Pro Leu Glu Glu Met Val Pro Leu Ser 
                325                 330                 335     


His Leu Glu Glu Glu Gln Pro Pro Ala Pro Glu Ser Pro Glu Ser Arg 
            340                 345                 350         


Ala Leu Val Gly Gln Ser Arg Arg Lys Pro Cys Glu Ser Asp Phe Glu 
        355                 360                 365             


Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly Ala Val Tyr Leu Val 
    370                 375                 380                 


Arg His Arg Asp Thr Arg Gln Arg Phe Ala Ile Lys Lys Ile Asn Lys 
385                 390                 395                 400 


Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln Val Phe Val Glu Arg 
                405                 410                 415     


Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe Val Val Ser Met Phe Cys 
            420                 425                 430         


Ser Phe Glu Thr Arg Arg His Leu Cys Met Val Met Glu Tyr Val Glu 
        435                 440                 445             


Gly Gly Asp Cys Ala Thr Leu Leu Lys Asn Met Gly Pro Leu Pro Val 
    450                 455                 460                 


Asp Met Ala Arg Leu Tyr Phe Ala Glu Thr Val Leu Ala Leu Glu Tyr 
465                 470                 475                 480 


Leu His Asn Tyr Gly Ile Val His Arg Asp Leu Lys Pro Asp Asn Leu 
                485                 490                 495     


Leu Ile Thr Ser Leu Gly His Ile Lys Leu Thr Asp Phe Gly Leu Ser 
            500                 505                 510         


Lys Ile Gly Leu Met Ser Met Ala Thr Asn Leu Tyr Glu Gly His Ile 
        515                 520                 525             


Glu Lys Asp Ala Arg Glu Phe Ile Asp Lys Gln Val Cys Gly Thr Pro 
    530                 535                 540                 


Glu Tyr Ile Ala Pro Glu Val Ile Phe Arg Gln Gly Tyr Gly Lys Pro 
545                 550                 555                 560 


Val Asp Trp Trp Ala Met Gly Val Val Leu Tyr Glu Phe Leu Val Gly 
                565                 570                 575     


Cys Val Pro Phe Phe Gly Asp Thr Pro Glu Glu Leu Phe Gly Gln Val 
            580                 585                 590         


Val Ser Asp Glu Ile Met Trp Pro Glu Gly Asp Glu Ala Leu Pro Ala 
        595                 600                 605             


Asp Ala Gln Asp Leu Ile Thr Arg Leu Leu Arg Gln Ser Pro Leu Asp 
    610                 615                 620                 


Arg Leu Gly Thr Gly Gly Thr His Glu Val Lys Gln His Pro Phe Phe 
625                 630                 635                 640 


Leu Ala Leu Asp Trp Ala Gly Leu Leu Arg His Lys Ala Glu Phe Val 
                645                 650                 655     


Pro Gln Leu Glu Ala Glu Asp Asp Thr Ser Tyr Phe Asp Thr Arg Ser 
            660                 665                 670         


Glu Arg Tyr Arg His Leu Gly Ser Glu Asp Asp Glu Thr Asn Asp Glu 
        675                 680                 685             


Glu Ser Ser Thr Glu Ile Pro Gln Phe Ser Ser Cys Ser His Arg Phe 
    690                 695                 700                 


Ser Lys Val Tyr Ser Ser Ser Glu Phe Leu Ala Val Gln Pro Thr Pro 
705                 710                 715                 720 


Thr Phe Ala Glu Arg Ser Phe Ser Glu Asp Arg Glu Glu Gly Trp Glu 
                725                 730                 735     


Arg Ser Glu Val Asp Tyr Gly Arg Arg Leu Ser Ala Asp Ile Arg Leu 
            740                 745                 750         


Arg Ser Trp Thr Ser Ser Gly Ser Ser Cys Gln Ser Ser Ser Ser Gln 
        755                 760                 765             


Pro Glu Arg Gly Pro Ser Pro Ser Leu Leu Asn Thr Ile Ser Leu Asp 
    770                 775                 780                 


Thr Met Pro Lys Phe Ala Phe Ser Ser Glu Asp Glu Gly Val Gly Pro 
785                 790                 795                 800 


Gly Pro Ala Gly Pro Lys Arg Pro Val Phe Ile Leu Gly Glu Pro Asp 
                805                 810                 815     


Pro Pro Pro Ala Ala Thr Pro Val Met Pro Lys Pro Ser Ser Leu Ser 
            820                 825                 830         


Ala Asp Thr Ala Ala Leu Ser His Ala Arg Leu Arg Ser Asn Ser Ile 
        835                 840                 845             


Gly Ala Arg His Ser Thr Pro Arg Pro Leu Asp Ala Gly Arg Gly Arg 
    850                 855                 860                 


Arg Leu Gly Gly Pro Arg Asp Pro Ala Pro Glu Lys Ser Arg Ala Ser 
865                 870                 875                 880 


Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Arg Val Pro Lys Ser 
                885                 890                 895     


Ala Ser Val Ser Ala Leu Ser Leu Ile Ile Thr Ala Asp Asp Gly Ser 
            900                 905                 910         


Gly Gly Pro Leu Met Ser Pro Leu Ser Pro Arg Ser Leu Ser Ser Asn 
        915                 920                 925             


Pro Ser Ser Arg Asp Ser Ser Pro Ser Arg Asp Pro Ser Pro Val Cys 
    930                 935                 940                 


Gly Ser Leu Arg Pro Pro Ile Val Ile His Ser Ser Gly Lys Lys Tyr 
945                 950                 955                 960 


Gly Phe Ser Leu Arg Ala Ile Arg Val Tyr Met Gly Asp Ser Asp Val 
                965                 970                 975     


Tyr Thr Val His His Val Val Trp Ser Val Glu Asp Gly Ser Pro Ala 
            980                 985                 990         


Gln Glu Ala Gly Leu Arg Ala Gly  Asp Leu Ile Thr His  Ile Asn Gly 
        995                 1000                 1005             


Glu Ser  Val Leu Gly Leu Val  His Met Asp Val Val  Glu Leu Leu 
    1010                 1015                 1020             


Leu Lys  Ser Gly Asn Lys Ile  Ser Leu Arg Thr Thr  Ala Leu Glu 
    1025                 1030                 1035             


Asn Thr  Ser Ile Lys Val Gly  Pro Ala Arg Lys Asn  Val Ala Lys 
    1040                 1045                 1050             


Gly Arg  Met Ala Arg Arg Ser  Lys Arg Ser Arg Arg  Arg Glu Thr 
    1055                 1060                 1065             


Gln Asp  Arg Arg Lys Ser Leu  Phe Lys Lys Ile Ser  Lys Gln Thr 
    1070                 1075                 1080             


Ser Val  Leu His Thr Ser Arg  Ser Phe Ser Ser Gly  Leu His His 
    1085                 1090                 1095             


Ser Leu  Ser Ser Ser Glu Ser  Leu Pro Gly Ser Pro  Thr His Ser 
    1100                 1105                 1110             


Leu Ser  Pro Ser Pro Thr Thr  Pro Cys Arg Ser Pro  Ala Pro Asp 
    1115                 1120                 1125             


Val Pro  Ala Asp Thr Thr Ala  Ser Pro Pro Ser Ala  Ser Pro Ser 
    1130                 1135                 1140             


Ser Ser  Ser Pro Ala Ser Pro  Ala Ala Ala Gly His  Thr Arg Pro 
    1145                 1150                 1155             


Ser Ser  Leu His Gly Leu Ala  Ala Lys Leu Gly Pro  Pro Arg Pro 
    1160                 1165                 1170             


Lys Thr  Gly Arg Arg Lys Ser  Thr Ser Ser Ile Pro  Pro Ser Pro 
    1175                 1180                 1185             


Leu Ala  Cys Pro Pro Ile Ser  Ala Pro Pro Pro Arg  Ser Pro Ser 
    1190                 1195                 1200             


Pro Leu  Pro Gly His Pro Pro  Ala Pro Ala Arg Ser  Pro Arg Leu 
    1205                 1210                 1215             


Arg Arg  Gly Gln Ser Ala Asp  Lys Leu Gly Thr Gly  Glu Arg Leu 
    1220                 1225                 1230             


Asp Gly  Glu Ala Gly Arg Arg  Thr Arg Gly Pro Glu  Ala Glu Leu 
    1235                 1240                 1245             


Val Val  Met Arg Arg Leu His  Leu Ser Glu Arg Arg  Asp Ser Phe 
    1250                 1255                 1260             


Lys Lys  Gln Glu Ala Val Gln  Glu Val Ser Phe Asp  Glu Pro Gln 
    1265                 1270                 1275             


Glu Glu  Ala Thr Gly Leu Pro  Thr Ser Val Pro Gln  Ile Ala Val 
    1280                 1285                 1290             


Glu Gly  Glu Glu Ala Val Pro  Val Ala Leu Gly Pro  Thr Gly Arg 
    1295                 1300                 1305             


Asp 
    


<210>  789
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  789

Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Glu Glu Gln Pro 
1               5                   10                  15      


Arg Phe Gln Ser Ala Ala Asp Lys Arg Ala His His Asn Ala Leu Glu 
            20                  25                  30          


Arg Lys Arg Arg Asp His Ile Lys Asp Ser Phe His Ser Leu Arg Asp 
        35                  40                  45              


Ser Val Pro Ser Leu Gln Gly Glu Lys Ala Ser Arg Ala Gln Ile Leu 
    50                  55                  60                  


Asp Lys Ala Thr Glu Tyr Ile Gln Tyr Met Arg Arg Lys Asn His Thr 
65                  70                  75                  80  


His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn Ala Leu Leu Glu 
                85                  90                  95      


Gln Gln Val Arg Ala Leu Glu Lys Ala Arg Ser Ser Ala Gln Leu Gln 
            100                 105                 110         


Thr Asn Tyr Pro Ser Ser Asp Asn Ser Leu Tyr Thr Asn Ala Lys Gly 
        115                 120                 125             


Ser Thr Ile Ser Ala Phe Asp Gly Gly Ser Asp Ser Ser Ser Glu Ser 
    130                 135                 140                 


Glu Pro Glu Glu Pro Gln Ser Arg Lys Lys Leu Arg Met Glu Ala Ser 
145                 150                 155                 160 


<210>  790
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  790

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 
    130                 135                 140                 


Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
145                 150                 155                 160 


Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 
                165                 170                 175     


Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
            180                 185     


<210>  791
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  791

Met Asp Leu Asp Lys Pro Ser Val Trp Gly Ser Leu Lys Gln Arg Thr 
1               5                   10                  15      


Arg Pro Leu Leu Ile Asn Leu Ser Lys Lys Lys Val Lys Lys Asn Pro 
            20                  25                  30          


Ser Lys Pro Pro Asp Leu Arg Ala Arg His His Leu Asp Arg Arg Leu 
        35                  40                  45              


Ser Leu Ser Val Pro Asp Leu Leu Glu Ala Glu Ala Leu Ala Pro Glu 
    50                  55                  60                  


Gly Arg Pro Tyr Ser Gly Pro Gln Ser Ser Tyr Thr Ser Val Pro Ser 
65                  70                  75                  80  


Ser Leu Ser Thr Ala Gly Ile Phe Pro Lys Ser Ser Ser Ser Ser Leu 
                85                  90                  95      


Lys Gln Ser Glu Glu Glu Leu Asp Trp Ser Gln Glu Glu Ala Ser His 
            100                 105                 110         


Leu His Val Val Glu Thr Asp Ser Glu Glu Ala Tyr Ala Ser Pro Ala 
        115                 120                 125             


Glu Arg Arg Arg Val Ser Ser Asn Gly Ile Phe Asp Leu Gln Lys Thr 
    130                 135                 140                 


Ser Leu Gly Gly Asp Ala Pro Glu Glu Pro Glu Lys Leu Cys Gly Ser 
145                 150                 155                 160 


Ser Asp Leu Asn Ala Ser Met Thr Ser Gln His Phe Glu Glu Gln Ser 
                165                 170                 175     


Val Pro Gly Glu Ala Ser Asp Gly Leu Ser Asn Leu Pro Ser Pro Phe 
            180                 185                 190         


Ala Tyr Leu Leu Thr Ile His Leu Lys Glu Gly Arg Asn Leu Val Val 
        195                 200                 205             


Arg Asp Arg Cys Gly Thr Ser Asp Pro Tyr Val Lys Phe Lys Leu Asn 
    210                 215                 220                 


Gly Lys Thr Leu Tyr Lys Ser Lys Val Ile Tyr Lys Asn Leu Asn Pro 
225                 230                 235                 240 


Val Trp Asp Glu Ile Val Val Leu Pro Ile Gln Ser Leu Asp Gln Lys 
                245                 250                 255     


Leu Arg Val Lys Val Tyr Asp Arg Asp Leu Thr Thr Ser Asp Phe Met 
            260                 265                 270         


Gly Ser Ala Phe Val Ile Leu Ser Asp Leu Glu Leu Asn Arg Thr Thr 
        275                 280                 285             


Glu His Ile Leu Lys Leu Glu Asp Pro Asn Ser Leu Glu Asp Asp Met 
    290                 295                 300                 


Gly Val Ile Val Leu Asn Leu Asn Leu Val Val Lys Gln Gly Asp Phe 
305                 310                 315                 320 


Lys Arg His Arg Trp Ser Asn Arg Lys Arg Leu Ser Ala Ser Lys Ser 
                325                 330                 335     


Ser Leu Ile Arg Asn Leu Arg Leu Ser Glu Ser Leu Lys Lys Asn Gln 
            340                 345                 350         


Leu Trp Asn Gly Ile Ile Ser Ile Thr Leu Leu Glu Gly Lys Asn Val 
        355                 360                 365             


Ser Gly Gly Ser Met Thr Glu Met Phe Val Gln Leu Lys Leu Gly Asp 
    370                 375                 380                 


Gln Arg Tyr Lys Ser Lys Thr Leu Cys Lys Ser Ala Asn Pro Gln Trp 
385                 390                 395                 400 


Gln Glu Gln Phe Asp Phe His Tyr Phe Ser Asp Arg Met Gly Ile Leu 
                405                 410                 415     


Asp Ile Glu Val Trp Gly Lys Asp Asn Lys Lys His Glu Glu Arg Leu 
            420                 425                 430         


Gly Thr Cys Lys Val Asp Ile Ser Ala Leu Pro Leu Lys Gln Ala Asn 
        435                 440                 445             


Cys Leu Glu Leu Pro Leu Asp Ser Cys Leu Gly Ala Leu Leu Met Leu 
    450                 455                 460                 


Val Thr Leu Thr Pro Cys Ala Gly Val Ser Val Ser Asp Leu Cys Val 
465                 470                 475                 480 


Cys Pro Leu Ala Asp Leu Ser Glu Arg Lys Gln Ile Thr Gln Arg Tyr 
                485                 490                 495     


Cys Leu Gln Asn Ser Leu Lys Asp Val Lys Asp Val Gly Ile Leu Gln 
            500                 505                 510         


Val Lys Val Leu Lys Ala Ala Asp Leu Leu Ala Ala Asp Phe Ser Gly 
        515                 520                 525             


Lys Ser Asp Pro Phe Cys Leu Leu Glu Leu Gly Asn Asp Arg Leu Gln 
    530                 535                 540                 


Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp Asn Lys Val Phe 
545                 550                 555                 560 


Thr Phe Pro Ile Lys Asp Ile His Asp Val Leu Glu Val Thr Val Phe 
                565                 570                 575     


Asp Glu Asp Gly Asp Lys Pro Pro Asp Phe Leu Gly Lys Val Ala Ile 
            580                 585                 590         


Pro Leu Leu Ser Ile Arg Asp Gly Gln Pro Asn Cys Tyr Val Leu Lys 
        595                 600                 605             


Asn Lys Asp Leu Glu Gln Ala Phe Lys Gly Val Ile Tyr Leu Glu Met 
    610                 615                 620                 


Asp Leu Ile Tyr Asn Pro Val Lys Ala Ser Ile Arg Thr Phe Thr Pro 
625                 630                 635                 640 


Arg Glu Lys Arg Phe Val Glu Asp Ser Arg Lys Leu Ser Lys Lys Ile 
                645                 650                 655     


Leu Ser Arg Asp Val Asp Arg Val Lys Arg Ile Thr Met Ala Ile Trp 
            660                 665                 670         


Asn Thr Met Gln Phe Leu Lys Ser Cys Phe Gln Trp Glu Ser Thr Leu 
        675                 680                 685             


Arg Ser Thr Ile Ala Phe Ala Val Phe Leu Ile Thr Val Trp Asn Phe 
    690                 695                 700                 


Glu Leu Tyr Met Ile Pro Leu Ala Leu Leu Leu Ile Phe Val Tyr Asn 
705                 710                 715                 720 


Phe Ile Arg Pro Val Lys Gly Lys Val Ser Ser Ile Gln Asp Ser Gln 
                725                 730                 735     


Glu Ser Thr Asp Ile Asp Asp Glu Glu Asp Glu Asp Asp Lys Glu Ser 
            740                 745                 750         


Glu Lys Lys Gly Leu Ile Glu Arg Ile Tyr Met Val Gln Asp Ile Val 
        755                 760                 765             


Ser Thr Val Gln Asn Val Leu Glu Glu Ile Ala Ser Phe Gly Glu Arg 
    770                 775                 780                 


Ile Lys Asn Thr Phe Asn Trp Thr Val Pro Phe Leu Ser Ser Leu Ala 
785                 790                 795                 800 


Cys Leu Ile Leu Ala Ala Ala Thr Ile Ile Leu Tyr Phe Ile Pro Leu 
                805                 810                 815     


Arg Tyr Ile Ile Leu Ile Trp Gly Ile Asn Lys Phe Thr Lys Lys Leu 
            820                 825                 830         


Arg Asn Pro Tyr Ser Ile Asp Asn Asn Glu Leu Leu Asp Phe Leu Ser 
        835                 840                 845             


Arg Val Pro Ser Asp Val Gln Lys Val Gln Tyr Ala Glu Leu Lys Leu 
    850                 855                 860                 


Cys Ser Ser His Ser Pro Leu Arg Lys Lys Arg Ser Ala Leu 
865                 870                 875             


<210>  792
<211>  2174
<212>  PRT
<213>  Homo sapiens

<400>  792

Met Ser Ala Ser Phe Val Pro Asn Gly Ala Ser Leu Glu Asp Cys His 
1               5                   10                  15      


Cys Asn Leu Phe Cys Leu Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys 
            20                  25                  30          


Tyr Val Trp Gln Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr 
        35                  40                  45              


Glu Glu Asp Pro Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp 
    50                  55                  60                  


Val Leu Gly Val Trp Arg Arg Asp Gln Arg Pro Gly Arg Arg Glu Leu 
65                  70                  75                  80  


Trp Ile Phe Trp Trp Gly Glu Asp Pro Ser Phe Ala Asp Leu Ile His 
                85                  90                  95      


His Asp Leu Ser Glu Glu Glu Asp Gly Val Trp Glu Asn Gly Leu Ser 
            100                 105                 110         


Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Val His Asn Leu Leu Glu 
        115                 120                 125             


Arg Cys Leu Met Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val 
    130                 135                 140                 


Lys Pro Tyr Glu Lys Asp Glu Lys Pro Ile Asn Lys Ser Glu His Leu 
145                 150                 155                 160 


Ser Cys Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr 
                165                 170                 175     


Ser Val Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu 
            180                 185                 190         


His Ile Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Val Ile Leu 
        195                 200                 205             


Cys Pro Phe Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Phe Lys Met 
    210                 215                 220                 


Ser Asp Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln Phe Tyr 
225                 230                 235                 240 


Pro Ile Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln Glu Asp 
                245                 250                 255     


Met Asp Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu Val Ala 
            260                 265                 270         


Gly Val Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro Gln Ser 
        275                 280                 285             


Asp Ile Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser Ser Ser 
    290                 295                 300                 


Cys Leu Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro Ala Met 
305                 310                 315                 320 


Ser Ser Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val Gln Thr 
                325                 330                 335     


Val Asp Pro Gln Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser 
            340                 345                 350         


Asp Gly Phe Asn Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro 
        355                 360                 365             


Arg Lys Leu Ala Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn 
    370                 375                 380                 


Met Asn Arg Ala Gln Asn Lys Arg Lys Tyr Ser Ala Ser Ser Gly Gly 
385                 390                 395                 400 


Leu Cys Glu Glu Ala Thr Ala Ala Lys Val Ala Ser Trp Asp Phe Val 
                405                 410                 415     


Glu Ala Thr Gln Arg Thr Asn Cys Ser Cys Leu Arg His Lys Asn Leu 
            420                 425                 430         


Lys Ser Arg Asn Ala Gly Gln Gln Gly Gln Ala Pro Ser Leu Gly Gln 
        435                 440                 445             


Gln Gln Gln Ile Leu Pro Lys His Lys Thr Asn Glu Lys Gln Glu Lys 
    450                 455                 460                 


Ser Glu Lys Pro Gln Lys Arg Pro Leu Thr Pro Phe His His Arg Val 
465                 470                 475                 480 


Ser Val Ser Asp Asp Val Gly Met Asp Ala Asp Ser Ala Ser Gln Arg 
                485                 490                 495     


Leu Val Ile Ser Ala Pro Asp Ser Gln Val Arg Phe Ser Asn Ile Arg 
            500                 505                 510         


Thr Asn Asp Val Ala Lys Thr Pro Gln Met His Gly Thr Glu Met Ala 
        515                 520                 525             


Asn Ser Pro Gln Pro Pro Pro Leu Ser Pro His Pro Cys Asp Val Val 
    530                 535                 540                 


Asp Glu Gly Val Thr Lys Thr Pro Ser Thr Pro Gln Ser Gln His Phe 
545                 550                 555                 560 


Tyr Gln Met Pro Thr Pro Asp Pro Leu Val Pro Ser Lys Pro Met Glu 
                565                 570                 575     


Asp Arg Ile Asp Ser Leu Ser Gln Ser Phe Pro Pro Gln Tyr Gln Glu 
            580                 585                 590         


Ala Val Glu Pro Thr Val Tyr Val Gly Thr Ala Val Asn Leu Glu Glu 
        595                 600                 605             


Asp Glu Ala Asn Ile Ala Trp Lys Tyr Tyr Lys Phe Pro Lys Lys Lys 
    610                 615                 620                 


Asp Val Glu Phe Leu Pro Pro Gln Leu Pro Ser Asp Lys Phe Lys Asp 
625                 630                 635                 640 


Asp Pro Val Gly Pro Phe Gly Gln Glu Ser Val Thr Ser Val Thr Glu 
                645                 650                 655     


Leu Met Val Gln Cys Lys Lys Pro Leu Lys Val Ser Asp Glu Leu Val 
            660                 665                 670         


Gln Gln Tyr Gln Ile Lys Asn Gln Cys Leu Ser Ala Ile Ala Ser Asp 
        675                 680                 685             


Ala Glu Gln Glu Pro Lys Ile Asp Pro Tyr Ala Phe Val Glu Gly Asp 
    690                 695                 700                 


Glu Glu Phe Leu Phe Pro Asp Lys Lys Asp Arg Gln Asn Ser Glu Arg 
705                 710                 715                 720 


Glu Ala Gly Lys Lys His Lys Val Glu Asp Gly Thr Ser Ser Val Thr 
                725                 730                 735     


Val Leu Ser His Glu Glu Asp Ala Met Ser Leu Phe Ser Pro Ser Ile 
            740                 745                 750         


Lys Gln Asp Ala Pro Arg Pro Thr Ser His Ala Arg Pro Pro Ser Thr 
        755                 760                 765             


Ser Leu Ile Tyr Asp Ser Asp Leu Ala Val Ser Tyr Thr Asp Leu Asp 
    770                 775                 780                 


Asn Leu Phe Asn Ser Asp Glu Asp Glu Leu Thr Pro Gly Ser Lys Lys 
785                 790                 795                 800 


Ser Ala Asn Gly Ser Asp Asp Lys Ala Ser Cys Lys Glu Ser Lys Thr 
                805                 810                 815     


Gly Asn Leu Asp Pro Leu Ser Cys Ile Ser Thr Ala Asp Leu His Lys 
            820                 825                 830         


Met Tyr Pro Thr Pro Pro Ser Leu Glu Gln His Ile Met Gly Phe Ser 
        835                 840                 845             


Pro Met Asn Met Asn Asn Lys Glu Tyr Gly Ser Met Asp Thr Thr Pro 
    850                 855                 860                 


Gly Gly Thr Val Leu Glu Gly Asn Ser Ser Ser Ile Gly Ala Gln Phe 
865                 870                 875                 880 


Lys Ile Glu Val Asp Glu Gly Phe Cys Ser Pro Lys Pro Ser Glu Ile 
                885                 890                 895     


Lys Asp Phe Ser Tyr Val Tyr Lys Pro Glu Asn Cys Gln Ile Leu Val 
            900                 905                 910         


Gly Cys Ser Met Phe Ala Pro Leu Lys Thr Leu Pro Ser Gln Tyr Leu 
        915                 920                 925             


Pro Pro Ile Lys Leu Pro Glu Glu Cys Ile Tyr Arg Gln Ser Trp Thr 
    930                 935                 940                 


Val Gly Lys Leu Glu Leu Leu Ser Ser Gly Pro Ser Met Pro Phe Ile 
945                 950                 955                 960 


Lys Glu Gly Asp Gly Ser Asn Met Asp Gln Glu Tyr Gly Thr Ala Tyr 
                965                 970                 975     


Thr Pro Gln Thr His Thr Ser Phe Gly Met Pro Pro Ser Ser Ala Pro 
            980                 985                 990         


Pro Ser Asn Ser Gly Ala Gly Ile  Leu Pro Ser Pro Ser  Thr Pro Arg 
        995                 1000                 1005             


Phe Pro  Thr Pro Arg Thr Pro  Arg Thr Pro Arg Thr  Pro Arg Gly 
    1010                 1015                 1020             


Ala Gly  Gly Pro Ala Ser Ala  Gln Gly Ser Val Lys  Tyr Glu Asn 
    1025                 1030                 1035             


Ser Asp  Leu Tyr Ser Pro Ala  Ser Thr Pro Ser Thr  Cys Arg Pro 
    1040                 1045                 1050             


Leu Asn  Ser Val Glu Pro Ala  Thr Val Pro Ser Ile  Pro Glu Ala 
    1055                 1060                 1065             


His Ser  Leu Tyr Val Asn Leu  Ile Leu Ser Glu Ser  Val Met Asn 
    1070                 1075                 1080             


Leu Phe  Lys Asp Cys Asn Phe  Asp Ser Cys Cys Ile  Cys Val Cys 
    1085                 1090                 1095             


Asn Met  Asn Ile Lys Gly Ala  Asp Val Gly Val Tyr  Ile Pro Asp 
    1100                 1105                 1110             


Pro Thr  Gln Glu Ala Gln Tyr  Arg Cys Thr Cys Gly  Phe Ser Ala 
    1115                 1120                 1125             


Val Met  Asn Arg Lys Phe Gly  Asn Asn Ser Gly Leu  Phe Leu Glu 
    1130                 1135                 1140             


Asp Glu  Leu Asp Ile Ile Gly  Arg Asn Thr Asp Cys  Gly Lys Glu 
    1145                 1150                 1155             


Ala Glu  Lys Arg Phe Glu Ala  Leu Arg Ala Thr Ser  Ala Glu His 
    1160                 1165                 1170             


Val Asn  Gly Gly Leu Lys Glu  Ser Glu Lys Leu Ser  Asp Asp Leu 
    1175                 1180                 1185             


Ile Leu  Leu Leu Gln Asp Gln  Cys Thr Asn Leu Phe  Ser Pro Phe 
    1190                 1195                 1200             


Gly Ala  Ala Asp Gln Asp Pro  Phe Pro Lys Ser Gly  Val Ile Ser 
    1205                 1210                 1215             


Asn Trp  Val Arg Val Glu Glu  Arg Asp Cys Cys Asn  Asp Cys Tyr 
    1220                 1225                 1230             


Leu Ala  Leu Glu His Gly Arg  Gln Phe Met Asp Asn  Met Ser Gly 
    1235                 1240                 1245             


Gly Lys  Val Asp Glu Ala Leu  Val Lys Ser Ser Cys  Leu His Pro 
    1250                 1255                 1260             


Trp Ser  Lys Arg Asn Asp Val  Ser Met Gln Cys Ser  Gln Asp Ile 
    1265                 1270                 1275             


Leu Arg  Met Leu Leu Ser Leu  Gln Pro Val Leu Gln  Asp Ala Ile 
    1280                 1285                 1290             


Gln Lys  Lys Arg Thr Val Arg  Pro Trp Gly Val Gln  Gly Pro Leu 
    1295                 1300                 1305             


Thr Trp  Gln Gln Phe His Lys  Met Ala Gly Arg Gly  Ser Tyr Gly 
    1310                 1315                 1320             


Thr Asp  Glu Ser Pro Glu Pro  Leu Pro Ile Pro Thr  Phe Leu Leu 
    1325                 1330                 1335             


Gly Tyr  Asp Tyr Asp Tyr Leu  Val Leu Ser Pro Phe  Ala Leu Pro 
    1340                 1345                 1350             


Tyr Trp  Glu Arg Leu Met Leu  Glu Pro Tyr Gly Ser  Gln Arg Asp 
    1355                 1360                 1365             


Ile Ala  Tyr Val Val Leu Cys  Pro Glu Asn Glu Ala  Leu Leu Asn 
    1370                 1375                 1380             


Gly Ala  Lys Ser Phe Phe Arg  Asp Leu Thr Ala Ile  Tyr Glu Ser 
    1385                 1390                 1395             


Cys Arg  Leu Gly Gln His Arg  Pro Val Ser Arg Leu  Leu Thr Asp 
    1400                 1405                 1410             


Gly Ile  Met Arg Val Gly Ser  Thr Ala Ser Lys Lys  Leu Ser Glu 
    1415                 1420                 1425             


Lys Leu  Val Ala Glu Trp Phe  Ser Gln Ala Ala Asp  Gly Asn Asn 
    1430                 1435                 1440             


Glu Ala  Phe Ser Lys Leu Lys  Leu Tyr Ala Gln Val  Cys Arg Tyr 
    1445                 1450                 1455             


Asp Leu  Gly Pro Tyr Leu Ala  Ser Leu Pro Leu Asp  Ser Ser Leu 
    1460                 1465                 1470             


Leu Ser  Gln Pro Asn Leu Val  Ala Pro Thr Ser Gln  Ser Leu Ile 
    1475                 1480                 1485             


Thr Pro  Pro Gln Met Thr Asn  Thr Gly Asn Ala Asn  Thr Pro Ser 
    1490                 1495                 1500             


Ala Thr  Leu Ala Ser Ala Ala  Ser Ser Thr Met Thr  Val Thr Ser 
    1505                 1510                 1515             


Gly Val  Ala Ile Ser Thr Ser  Val Ala Thr Ala Asn  Ser Thr Leu 
    1520                 1525                 1530             


Thr Thr  Ala Ser Thr Ser Ser  Ser Ser Ser Ser Asn  Leu Asn Ser 
    1535                 1540                 1545             


Gly Val  Ser Ser Asn Lys Leu  Pro Ser Phe Pro Pro  Phe Gly Ser 
    1550                 1555                 1560             


Met Asn  Ser Asn Ala Ala Gly  Ser Met Ser Thr Gln  Ala Asn Thr 
    1565                 1570                 1575             


Val Gln  Ser Gly Gln Leu Gly  Gly Gln Gln Thr Ser  Ala Leu Gln 
    1580                 1585                 1590             


Thr Ala  Gly Ile Ser Gly Glu  Ser Ser Ser Leu Pro  Thr Gln Pro 
    1595                 1600                 1605             


His Pro  Asp Val Ser Glu Ser  Thr Met Asp Arg Asp  Lys Val Gly 
    1610                 1615                 1620             


Ile Pro  Thr Asp Gly Asp Ser  His Ala Val Thr Tyr  Pro Pro Ala 
    1625                 1630                 1635             


Ile Val  Val Tyr Ile Ile Asp  Pro Phe Thr Tyr Glu  Asn Thr Asp 
    1640                 1645                 1650             


Glu Ser  Thr Asn Ser Ser Ser  Val Trp Thr Leu Gly  Leu Leu Arg 
    1655                 1660                 1665             


Cys Phe  Leu Glu Met Val Gln  Thr Leu Pro Pro His  Ile Lys Ser 
    1670                 1675                 1680             


Thr Val  Ser Val Gln Ile Ile  Pro Cys Gln Tyr Leu  Leu Gln Pro 
    1685                 1690                 1695             


Val Lys  His Glu Asp Arg Glu  Ile Tyr Pro Gln His  Leu Lys Ser 
    1700                 1705                 1710             


Leu Ala  Phe Ser Ala Phe Thr  Gln Cys Arg Arg Pro  Leu Pro Thr 
    1715                 1720                 1725             


Ser Thr  Asn Val Lys Thr Leu  Thr Gly Phe Gly Pro  Gly Leu Ala 
    1730                 1735                 1740             


Met Glu  Thr Ala Leu Arg Ser  Pro Asp Arg Pro Glu  Cys Ile Arg 
    1745                 1750                 1755             


Leu Tyr  Ala Pro Pro Phe Ile  Leu Ala Pro Val Lys  Asp Lys Gln 
    1760                 1765                 1770             


Thr Glu  Leu Gly Glu Thr Phe  Gly Glu Ala Gly Gln  Lys Tyr Asn 
    1775                 1780                 1785             


Val Leu  Phe Val Gly Tyr Cys  Leu Ser His Asp Gln  Arg Trp Ile 
    1790                 1795                 1800             


Leu Ala  Ser Cys Thr Asp Leu  Tyr Gly Glu Leu Leu  Glu Thr Cys 
    1805                 1810                 1815             


Ile Ile  Asn Ile Asp Val Pro  Asn Arg Ala Arg Arg  Lys Lys Ser 
    1820                 1825                 1830             


Ser Ala  Arg Lys Phe Gly Leu  Gln Lys Leu Trp Glu  Trp Cys Leu 
    1835                 1840                 1845             


Gly Leu  Val Gln Met Ser Ser  Leu Pro Trp Arg Val  Val Ile Gly 
    1850                 1855                 1860             


Arg Leu  Gly Arg Ile Gly His  Gly Glu Leu Lys Asp  Trp Ser Cys 
    1865                 1870                 1875             


Leu Leu  Ser Arg Arg Asn Leu  Gln Ser Leu Ser Lys  Arg Leu Lys 
    1880                 1885                 1890             


Asp Met  Cys Arg Met Cys Gly  Ile Ser Ala Ala Asp  Ser Pro Ser 
    1895                 1900                 1905             


Ile Leu  Ser Ala Cys Leu Val  Ala Met Glu Pro Gln  Gly Ser Phe 
    1910                 1915                 1920             


Val Ile  Met Pro Asp Ser Val  Ser Thr Gly Ser Val  Phe Gly Arg 
    1925                 1930                 1935             


Ser Thr  Thr Leu Asn Met Gln  Thr Ser Gln Leu Asn  Thr Pro Gln 
    1940                 1945                 1950             


Asp Thr  Ser Cys Thr His Ile  Leu Val Phe Pro Thr  Ser Ala Ser 
    1955                 1960                 1965             


Val Gln  Val Ala Ser Ala Thr  Tyr Thr Thr Glu Asn  Leu Asp Leu 
    1970                 1975                 1980             


Ala Phe  Asn Pro Asn Asn Asp  Gly Ala Asp Gly Met  Gly Ile Phe 
    1985                 1990                 1995             


Asp Leu  Leu Asp Thr Gly Asp  Asp Leu Asp Pro Asp  Ile Ile Asn 
    2000                 2005                 2010             


Ile Leu  Pro Ala Ser Pro Thr  Gly Ser Pro Val His  Ser Pro Gly 
    2015                 2020                 2025             


Ser His  Tyr Pro His Gly Gly  Asp Ala Gly Lys Gly  Gln Ser Thr 
    2030                 2035                 2040             


Asp Arg  Leu Leu Ser Thr Glu  Pro His Glu Glu Val  Pro Asn Ile 
    2045                 2050                 2055             


Leu Gln  Gln Pro Leu Ala Leu  Gly Tyr Phe Val Ser  Thr Ala Lys 
    2060                 2065                 2070             


Ala Gly  Pro Leu Pro Asp Trp  Phe Trp Ser Ala Cys  Pro Gln Ala 
    2075                 2080                 2085             


Gln Tyr  Gln Cys Pro Leu Phe  Leu Lys Ala Ser Leu  His Leu His 
    2090                 2095                 2100             


Val Pro  Ser Val Gln Ser Asp  Glu Leu Leu His Ser  Lys His Ser 
    2105                 2110                 2115             


His Pro  Leu Asp Ser Asn Gln  Thr Ser Asp Val Leu  Arg Phe Val 
    2120                 2125                 2130             


Leu Glu  Gln Tyr Asn Ala Leu  Ser Trp Leu Thr Cys  Asp Pro Ala 
    2135                 2140                 2145             


Thr Gln  Asp Arg Arg Ser Cys  Leu Pro Ile His Phe  Val Val Leu 
    2150                 2155                 2160             


Asn Gln  Leu Tyr Asn Phe Ile  Met Asn Met Leu 
    2165                 2170                 


<210>  793
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  793

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Ser Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu His Arg Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Thr Ser Tyr Val Leu Thr Pro His Thr Glu 
            100                 105                 110         


Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Met Arg Asn 
        115                 120                 125             


His Lys Ile Ala Pro Gly Leu Pro Pro Gln Asn Phe Ser Met Ser Val 
    130                 135                 140                 


Thr Val Pro Val Thr Ser Pro Asn Ala Leu Ser Tyr Thr Asn Pro Gly 
145                 150                 155                 160 


Ser Ser Leu Val Ser Pro Ser Leu Ala Ala Ser Ser Thr Leu Thr Asp 
                165                 170                 175     


Ser Ser Met Leu Ser Pro Pro Gln Thr Thr Leu His Arg Asn Val Ser 
            180                 185                 190         


Pro Gly Ala Pro Gln Arg Pro Pro Ser Thr Gly Asn Ala Gly Gly Met 
        195                 200                 205             


Leu Ser Thr Thr Asp Leu Thr Val Pro Asn Gly Ala Gly Ser Ser Pro 
    210                 215                 220                 


Val Gly Asn Gly Phe Val Asn Ser Arg Ala Ser Pro Asn Leu Ile Gly 
225                 230                 235                 240 


Ala Thr Gly Ala Asn Ser Leu Gly Lys Val Met Pro Thr Lys Ser Pro 
                245                 250                 255     


Pro Pro Pro Gly Gly Gly Asn Leu Gly Met Asn Ser Arg Lys Pro Asp 
            260                 265                 270         


Leu Arg Val Val Ile Pro Pro Ser Ser Lys Gly Met Met Pro Pro Leu 
        275                 280                 285             


Asn Thr Gln Arg Ile Ser Ser Ser Gln Ala Thr Gln Pro Leu Ala Thr 
    290                 295                 300                 


Pro Val Val Ser Val Thr Thr Pro Ser Leu Pro Pro Gln Gly Leu Val 
305                 310                 315                 320 


Tyr Ser Ala Met Pro Thr Ala Tyr Asn Thr Asp Tyr Ser Leu Thr Ser 
                325                 330                 335     


Ala Asp Leu Ser Ala Leu Gln Gly Phe Asn Ser Pro Gly Met Leu Ser 
            340                 345                 350         


Leu Gly Gln Val Ser Ala Trp Gln Gln His His Leu Gly Gln Ala Ala 
        355                 360                 365             


Leu Ser Ser Leu Val Ala Gly Gly Gln Leu Ser Gln Gly Ser Asn Leu 
    370                 375                 380                 


Ser Ile Asn Thr Asn Gln Asn Ile Ser Ile Lys Ser Glu Pro Ile Ser 
385                 390                 395                 400 


Pro Pro Arg Asp Arg Met Thr Pro Ser Gly Phe Gln Gln Gln Gln Gln 
                405                 410                 415     


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Gln Pro Gln Pro Gln 
            420                 425                 430         


Pro Pro Gln Pro Gln Pro Arg Gln Glu Met Gly Arg Ser Pro Val Asp 
        435                 440                 445             


Ser Leu Ser Ser Ser Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp 
    450                 455                 460                 


Pro Arg Gly Asp Phe His Ser Pro Ile Val Leu Gly Arg Pro Pro Asn 
465                 470                 475                 480 


Thr Glu Asp Arg Glu Ser Pro Ser Val Lys Arg Met Arg Met Asp Ala 
                485                 490                 495     


Trp Val Thr 
            


<210>  794
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Ser Asp Thr Trp Ser Ser Ile Gln Ala His Lys Lys Gln Leu Asp 
1               5                   10                  15      


Ser Leu Arg Glu Arg Leu Gln Arg Arg Arg Lys Gln Asp Ser Gly His 
            20                  25                  30          


Leu Asp Leu Arg Asn Pro Glu Ala Ala Leu Ser Pro Thr Phe Arg Ser 
        35                  40                  45              


Asp Ser Pro Val Pro Thr Ala Pro Thr Ser Gly Gly Pro Lys Pro Ser 
    50                  55                  60                  


Thr Ala Ser Ala Val Pro Glu Leu Ala Thr Asp Pro Glu Leu Glu Lys 
65                  70                  75                  80  


Lys Leu Leu His His Leu Ser Asp Leu Ala Leu Thr Leu Pro Thr Asp 
                85                  90                  95      


Ala Val Ser Ile Cys Leu Ala Ile Ser Thr Pro Asp Ala Pro Ala Thr 
            100                 105                 110         


Gln Asp Gly Val Glu Ser Leu Leu Gln Lys Phe Ala Ala Gln Glu Leu 
        115                 120                 125             


Ile Glu Val Lys Arg Gly Leu Leu Gln Asp Asp Ala His Pro Thr Leu 
    130                 135                 140                 


Val Thr Tyr Ala Asp His Ser Lys Leu Ser Ala Met Met Gly Ala Val 
145                 150                 155                 160 


Ala Glu Lys Lys Gly Pro Gly Glu Val Ala Gly Thr Val Thr Gly Gln 
                165                 170                 175     


Lys Arg Arg Ala Glu Gln Asp Ser Thr Thr Val Ala Ala Phe Ala Ser 
            180                 185                 190         


Ser Leu Val Ser Gly Leu Asn Ser Ser Ala Ser Glu Pro Ala Lys Glu 
        195                 200                 205             


Pro Ala Lys Lys Ser Arg Lys His Ala Ala Ser Asp Val Asp Leu Glu 
    210                 215                 220                 


Ile Glu Ser Leu Leu Asn Gln Gln Ser Thr Lys Glu Gln Gln Ser Lys 
225                 230                 235                 240 


Lys Val Ser Gln Glu Ile Leu Glu Leu Leu Asn Thr Thr Thr Ala Lys 
                245                 250                 255     


Glu Gln Ser Ile Val Glu Lys Phe Arg Ser Arg Gly Arg Ala Gln Val 
            260                 265                 270         


Gln Glu Phe Cys Asp Tyr Gly Thr Lys Glu Glu Cys Met Lys Ala Ser 
        275                 280                 285             


Asp Ala Asp Arg Pro Cys Arg Lys Leu His Phe Arg Arg Ile Ile Asn 
    290                 295                 300                 


Lys His Thr Asp Glu Ser Leu Gly Asp Cys Ser Phe Leu Asn Thr Cys 
305                 310                 315                 320 


Phe His Met Asp Thr Cys Lys Tyr Val His Tyr Glu Ile Asp Ala Cys 
                325                 330                 335     


Met Asp Ser Glu Ala Pro Gly Ser Lys Asp His Thr Pro Ser Gln Glu 
            340                 345                 350         


Leu Ala Leu Thr Gln Ser Val Gly Gly Asp Ser Ser Ala Asp Arg Leu 
        355                 360                 365             


Phe Pro Pro Gln Trp Ile Cys Cys Asp Ile Arg Tyr Leu Asp Val Ser 
    370                 375                 380                 


Ile Leu Gly Lys Phe Ala Val Val Met Ala Asp Pro Pro Trp Asp Ile 
385                 390                 395                 400 


His Met Glu Leu Pro Tyr Gly Thr Leu Thr Asp Asp Glu Met Arg Arg 
                405                 410                 415     


Leu Asn Ile Pro Val Leu Gln Asp Asp Gly Phe Leu Phe Leu Trp Val 
            420                 425                 430         


Thr Gly Arg Ala Met Glu Leu Gly Arg Glu Cys Leu Asn Leu Trp Gly 
        435                 440                 445             


Tyr Glu Arg Val Asp Glu Ile Ile Trp Val Lys Thr Asn Gln Leu Gln 
    450                 455                 460                 


Arg Ile Ile Arg Thr Gly Arg Thr Gly His Trp Leu Asn His Gly Lys 
465                 470                 475                 480 


Glu His Cys Leu Val Gly Val Lys Gly Asn Pro Gln Gly Phe Asn Gln 
                485                 490                 495     


Gly Leu Asp Cys Asp Val Ile Val Ala Glu Val Arg Ser Thr Ser His 
            500                 505                 510         


Lys Pro Asp Glu Ile Tyr Gly Met Ile Glu Arg Leu Ser Pro Gly Thr 
        515                 520                 525             


Arg Lys Ile Glu Leu Phe Gly Arg Pro His Asn Val Gln Pro Asn Trp 
    530                 535                 540                 


Ile Thr Leu Gly Asn Gln Leu Asp Gly Ile His Leu Leu Asp Pro Asp 
545                 550                 555                 560 


Val Val Ala Arg Phe Lys Gln Arg Tyr Pro Asp Gly Ile Ile Ser Lys 
                565                 570                 575     


Pro Lys Asn Leu 
            580 


<210>  795
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  795

Met Ala Ala Gly Gly Ala Val Ala Ala Ala Pro Glu Cys Arg Leu Leu 
1               5                   10                  15      


Pro Tyr Ala Leu His Lys Trp Ser Ser Phe Ser Ser Thr Tyr Leu Pro 
            20                  25                  30          


Glu Asn Ile Leu Val Asp Lys Pro Asn Asp Gln Ser Ser Arg Trp Ser 
        35                  40                  45              


Ser Glu Ser Asn Tyr Pro Pro Gln Tyr Leu Ile Leu Lys Leu Glu Arg 
    50                  55                  60                  


Pro Ala Ile Val Gln Asn Ile Thr Phe Gly Lys Tyr Glu Lys Thr His 
65                  70                  75                  80  


Val Cys Asn Leu Lys Lys Phe Lys Val Phe Gly Gly Met Asn Glu Glu 
                85                  90                  95      


Asn Met Thr Glu Leu Leu Ser Ser Gly Leu Lys Asn Asp Tyr Asn Lys 
            100                 105                 110         


Glu Thr Phe Thr Leu Lys His Lys Ile Asp Glu Gln Met Phe Pro Cys 
        115                 120                 125             


Arg Phe Ile Lys Ile Val Pro Leu Leu Ser Trp Gly Pro Ser Phe Asn 
    130                 135                 140                 


Phe Ser Ile Trp Tyr Val Glu Leu Ser Gly Ile Asp Asp Pro Asp Ile 
145                 150                 155                 160 


Val Gln Pro Cys Leu Asn Trp Tyr Ser Lys Tyr Arg Glu Gln Glu Ala 
                165                 170                 175     


Ile Arg Leu Cys Leu Lys His Phe Arg Gln His Asn Tyr Thr Glu Ala 
            180                 185                 190         


Phe Glu Ser Leu Gln Lys Lys Thr Lys Ile Ala Leu Glu His Pro Met 
        195                 200                 205             


Leu Thr Asp Ile His Asp Lys Leu Val Leu Lys Gly Asp Phe Asp Ala 
    210                 215                 220                 


Cys Glu Glu Leu Ile Glu Lys Ala Val Asn Asp Gly Leu Phe Asn Gln 
225                 230                 235                 240 


Tyr Ile Ser Gln Gln Glu Tyr Lys Pro Arg Trp Ser Gln Ile Ile Pro 
                245                 250                 255     


Lys Ser Thr Lys Gly Asp Gly Glu Asp Asn Arg Pro Gly Met Arg Gly 
            260                 265                 270         


Gly His Gln Met Val Ile Asp Val Gln Thr Glu Thr Val Tyr Leu Phe 
        275                 280                 285             


Gly Gly Trp Asp Gly Thr Gln Asp Leu Ala Asp Phe Trp Ala Tyr Ser 
    290                 295                 300                 


Val Lys Glu Asn Gln Trp Thr Cys Ile Ser Arg Asp Thr Glu Lys Glu 
305                 310                 315                 320 


Asn Gly Pro Ser Ala Arg Ser Cys His Lys Met Cys Ile Asp Ile Gln 
                325                 330                 335     


Arg Arg Gln Ile Tyr Thr Leu Gly Arg Tyr Leu Asp Ser Ser Val Arg 
            340                 345                 350         


Asn Ser Lys Ser Leu Lys Ser Asp Phe Tyr Arg Tyr Asp Ile Asp Thr 
        355                 360                 365             


Asn Thr Trp Met Leu Leu Ser Glu Asp Thr Ala Ala Asp Gly Gly Pro 
    370                 375                 380                 


Lys Leu Val Phe Asp His Gln Met Cys Met Asp Ser Glu Lys His Met 
385                 390                 395                 400 


Ile Tyr Thr Phe Gly Gly Arg Ile Leu Thr Cys Asn Gly Ser Val Asp 
                405                 410                 415     


Asp Ser Arg Ala Ser Glu Pro Gln Phe Ser Gly Leu Phe Ala Phe Asn 
            420                 425                 430         


Cys Gln Cys Gln Thr Trp Lys Leu Leu Arg Glu Asp Ser Cys Asn Ala 
        435                 440                 445             


Gly Pro Glu Asp Ile Gln Ser Arg Ile Gly His Cys Met Leu Phe His 
    450                 455                 460                 


Ser Lys Asn Arg Cys Leu Tyr Val Phe Gly Gly Gln Arg Ser Lys Thr 
465                 470                 475                 480 


Tyr Leu Asn Asp Phe Phe Ser Tyr Asp Val Asp Ser Asp His Val Asp 
                485                 490                 495     


Ile Ile Ser Asp Gly Thr Lys Lys Asp Ser Gly Met Val Pro Met Thr 
            500                 505                 510         


Gly Phe Thr Gln Arg Ala Thr Ile Asp Pro Glu Leu Asn Glu Ile His 
        515                 520                 525             


Val Leu Ser Gly Leu Ser Lys Asp Lys Glu Lys Arg Glu Glu Asn Val 
    530                 535                 540                 


Arg Asn Ser Phe Trp Ile Tyr Asp Ile Val Arg Asn Ser Trp Ser Cys 
545                 550                 555                 560 


Val Tyr Lys Asn Asp Gln Ala Ala Lys Asp Asn Pro Thr Lys Ser Leu 
                565                 570                 575     


Gln Glu Glu Glu Pro Cys Pro Arg Phe Ala His Gln Leu Val Tyr Asp 
            580                 585                 590         


Glu Leu His Lys Val His Tyr Leu Phe Gly Gly Asn Pro Gly Lys Ser 
        595                 600                 605             


Cys Ser Pro Lys Met Arg Leu Asp Asp Phe Trp Ser Leu Lys Leu Cys 
    610                 615                 620                 


Arg Pro Ser Lys Asp Tyr Leu Leu Arg His Cys Lys Tyr Leu Ile Arg 
625                 630                 635                 640 


Lys His Arg Phe Glu Glu Lys Ala Gln Val Asp Pro Leu Ser Ala Leu 
                645                 650                 655     


Lys Tyr Leu Gln Asn Asp Leu Tyr Ile Thr Val Asp His Ser Asp Pro 
            660                 665                 670         


Glu Glu Thr Lys Glu Phe Gln Leu Leu Ala Ser Ala Leu Phe Lys Ser 
        675                 680                 685             


Gly Ser Asp Phe Thr Ala Leu Gly Phe Ser Asp Val Asp His Thr Tyr 
    690                 695                 700                 


Ala Gln Arg Thr Gln Leu Phe Asp Thr Leu Val Asn Phe Phe Pro Asp 
705                 710                 715                 720 


Ser Met Thr Pro Pro Lys Gly Asn Leu Val Asp Leu Ile Thr Leu 
                725                 730                 735 


<210>  796
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  796

Met Ala Glu Ala Ala Thr Pro Gly Thr Thr Ala Thr Thr Ser Gly Ala 
1               5                   10                  15      


Gly Ala Ala Ala Ala Thr Ala Ala Ala Ala Ser Pro Thr Pro Ile Pro 
            20                  25                  30          


Thr Val Thr Ala Pro Ser Leu Gly Ala Gly Gly Gly Gly Gly Gly Ser 
        35                  40                  45              


Asp Gly Ser Gly Gly Gly Trp Thr Lys Gln Val Thr Cys Arg Tyr Phe 
    50                  55                  60                  


Met His Gly Val Cys Lys Glu Gly Asp Asn Cys Arg Tyr Ser His Asp 
65                  70                  75                  80  


Leu Ser Asp Ser Pro Tyr Ser Val Val Cys Lys Tyr Phe Gln Arg Gly 
                85                  90                  95      


Tyr Cys Ile Tyr Gly Asp Arg Cys Arg Tyr Glu His Ser Lys Pro Leu 
            100                 105                 110         


Lys Gln Glu Glu Ala Thr Ala Thr Glu Leu Thr Thr Lys Ser Ser Leu 
        115                 120                 125             


Ala Ala Ser Ser Ser Leu Ser Ser Ile Val Gly Pro Leu Val Glu Met 
    130                 135                 140                 


Asn Thr Gly Glu Ala Glu Ser Arg Asn Ser Asn Phe Ala Thr Val Gly 
145                 150                 155                 160 


Ala Gly Ser Glu Asp Trp Val Asn Ala Ile Glu Phe Val Pro Gly Gln 
                165                 170                 175     


Pro Tyr Cys Gly Arg Thr Ala Pro Ser Cys Thr Glu Ala Pro Leu Gln 
            180                 185                 190         


Gly Ser Val Thr Lys Glu Glu Ser Glu Lys Glu Gln Thr Ala Val Glu 
        195                 200                 205             


Thr Lys Lys Gln Leu Cys Pro Tyr Ala Ala Val Gly Glu Cys Arg Tyr 
    210                 215                 220                 


Gly Glu Asn Cys Val Tyr Leu His Gly Asp Ser Cys Asp Met Cys Gly 
225                 230                 235                 240 


Leu Gln Val Leu His Pro Met Asp Ala Ala Gln Arg Ser Gln His Ile 
                245                 250                 255     


Lys Ser Cys Ile Glu Ala His Glu Lys Asp Met Glu Leu Ser Phe Ala 
            260                 265                 270         


Val Gln Arg Ser Lys Asp Met Val Cys Gly Ile Cys Met Glu Val Val 
        275                 280                 285             


Tyr Glu Lys Ala Asn Pro Ser Glu Arg Arg Phe Gly Ile Leu Ser Asn 
    290                 295                 300                 


Cys Asn His Thr Tyr Cys Leu Lys Cys Ile Arg Lys Trp Arg Ser Ala 
305                 310                 315                 320 


Lys Gln Phe Glu Ser Lys Ile Ile Lys Ser Cys Pro Glu Cys Arg Ile 
                325                 330                 335     


Thr Ser Asn Phe Val Ile Pro Ser Glu Tyr Trp Val Glu Glu Lys Glu 
            340                 345                 350         


Glu Lys Gln Lys Leu Ile Leu Lys Tyr Lys Glu Ala Met Ser Asn Lys 
        355                 360                 365             


Ala Cys Arg Tyr Phe Asp Glu Gly Arg Gly Ser Cys Pro Phe Gly Gly 
    370                 375                 380                 


Asn Cys Phe Tyr Lys His Ala Tyr Pro Asp Gly Arg Arg Glu Glu Pro 
385                 390                 395                 400 


Gln Arg Gln Lys Val Gly Thr Ser Ser Arg Tyr Arg Ala Gln Arg Arg 
                405                 410                 415     


Asn His Phe Trp Glu Leu Ile Glu Glu Arg Glu Asn Ser Asn Pro Phe 
            420                 425                 430         


Asp Asn Asp Glu Glu Glu Val Val Thr Phe Glu Leu Gly Glu Met Leu 
        435                 440                 445             


Leu Met Leu Leu Ala Ala Gly Gly Asp Asp Glu Leu Thr Asp Ser Glu 
    450                 455                 460                 


Asp Glu Trp Asp Leu Phe His Asp Glu Leu Glu Asp Phe Tyr Asp Leu 
465                 470                 475                 480 


Asp Leu 
        


<210>  797
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  797

Met Arg Leu Arg Leu Arg Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Pro Pro Ala Arg Ala Pro Lys Pro Ser Ala Gln Asp Val Ser Leu Gly 
            20                  25                  30          


Val Asp Trp Leu Thr Arg Tyr Gly Tyr Leu Pro Pro Pro His Pro Ala 
        35                  40                  45              


Gln Ala Gln Leu Gln Ser Pro Glu Lys Leu Arg Asp Ala Ile Lys Val 
    50                  55                  60                  


Met Gln Arg Phe Ala Gly Leu Pro Glu Thr Gly Arg Met Asp Pro Gly 
65                  70                  75                  80  


Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu Pro Asp Val Leu 
                85                  90                  95      


Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly 
            100                 105                 110         


Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro 
        115                 120                 125             


Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val Leu Met Ser Tyr 
    130                 135                 140                 


Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr Phe His Glu Val 
145                 150                 155                 160 


Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg 
                165                 170                 175     


Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu Gly Gly Thr Leu 
            180                 185                 190         


Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His 
        195                 200                 205             


Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys Asp Gly Glu Gly 
    210                 215                 220                 


Thr Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly 
225                 230                 235                 240 


Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln 
                245                 250                 255     


Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu Ser Gln Asp Asp Arg 
            260                 265                 270         


Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro Gln Thr Pro Tyr Asp 
        275                 280                 285             


Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro Gln Pro Pro Ala Ser 
    290                 295                 300                 


Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp Arg Cys Glu Gly Asn 
305                 310                 315                 320 


Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly 
                325                 330                 335     


Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg 
            340                 345                 350         


Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Gln Val Arg 
        355                 360                 365             


Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu 
    370                 375                 380                 


Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly 
385                 390                 395                 400 


Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro Gly Glu Glu Val 
                405                 410                 415     


Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val Arg 
            420                 425                 430         


Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp Pro 
        435                 440                 445             


Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro Ser Pro 
    450                 455                 460                 


Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys Gly 
465                 470                 475                 480 


Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro Asp 
                485                 490                 495     


Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys Pro Ala Pro Ser 
            500                 505                 510         


Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala Thr Pro Val Ser Glu 
        515                 520                 525             


Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala Ala Gly Arg Trp Pro 
    530                 535                 540                 


Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu Val Gly Gly Val Ala 
545                 550                 555                 560 


Ser Arg 
        


<210>  798
<211>  939
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Ala Ala Gln Pro Pro Arg Gly Ile Arg Leu Ser Ala Leu Cys Pro 
1               5                   10                  15      


Lys Phe Leu His Thr Asn Ser Thr Ser His Thr Trp Pro Phe Ser Ala 
            20                  25                  30          


Val Ala Glu Leu Ile Asp Asn Ala Tyr Asp Pro Asp Val Asn Ala Lys 
        35                  40                  45              


Gln Ile Trp Ile Asp Lys Thr Val Ile Asn Asp His Ile Cys Leu Thr 
    50                  55                  60                  


Phe Thr Asp Asn Gly Asn Gly Met Thr Ser Asp Lys Leu His Lys Met 
65                  70                  75                  80  


Leu Ser Phe Gly Phe Ser Asp Lys Val Thr Met Asn Gly His Val Pro 
                85                  90                  95      


Val Gly Leu Tyr Gly Asn Gly Phe Lys Ser Gly Ser Met Arg Leu Gly 
            100                 105                 110         


Lys Asp Ala Ile Val Phe Thr Lys Asn Gly Glu Ser Met Ser Val Gly 
        115                 120                 125             


Leu Leu Ser Gln Thr Tyr Leu Glu Val Ile Lys Ala Glu His Val Val 
    130                 135                 140                 


Val Pro Ile Val Ala Phe Asn Lys His Arg Gln Met Ile Asn Leu Ala 
145                 150                 155                 160 


Glu Ser Lys Ala Ser Leu Ala Ala Ile Leu Glu His Ser Leu Phe Ser 
                165                 170                 175     


Thr Glu Gln Lys Leu Leu Ala Glu Leu Asp Ala Ile Ile Gly Lys Lys 
            180                 185                 190         


Gly Thr Arg Ile Ile Ile Trp Asn Leu Arg Ser Tyr Lys Asn Ala Thr 
        195                 200                 205             


Glu Phe Asp Phe Glu Lys Asp Lys Tyr Asp Ile Arg Ile Pro Glu Asp 
    210                 215                 220                 


Leu Asp Glu Ile Thr Gly Lys Lys Gly Tyr Lys Lys Gln Glu Arg Met 
225                 230                 235                 240 


Asp Gln Ile Ala Pro Glu Ser Asp Tyr Ser Leu Arg Ala Tyr Cys Ser 
                245                 250                 255     


Ile Leu Tyr Leu Lys Pro Arg Met Gln Ile Ile Leu Arg Gly Gln Lys 
            260                 265                 270         


Val Lys Thr Gln Leu Val Ser Lys Ser Leu Ala Tyr Ile Glu Arg Asp 
        275                 280                 285             


Val Tyr Arg Pro Lys Phe Leu Ser Lys Thr Val Arg Ile Thr Phe Gly 
    290                 295                 300                 


Phe Asn Cys Arg Asn Lys Asp His Tyr Gly Ile Met Met Tyr His Arg 
305                 310                 315                 320 


Asn Arg Leu Ile Lys Ala Tyr Glu Lys Val Gly Cys Gln Leu Arg Ala 
                325                 330                 335     


Asn Asn Met Gly Val Gly Val Val Gly Ile Ile Glu Cys Asn Phe Leu 
            340                 345                 350         


Lys Pro Thr His Asn Lys Gln Asp Phe Asp Tyr Thr Asn Glu Tyr Arg 
        355                 360                 365             


Leu Thr Ile Thr Ala Leu Gly Glu Lys Leu Asn Asp Tyr Trp Asn Glu 
    370                 375                 380                 


Met Lys Val Lys Lys Asn Thr Glu Tyr Pro Leu Asn Leu Pro Val Glu 
385                 390                 395                 400 


Asp Ile Gln Lys Arg Pro Asp Gln Thr Trp Val Gln Cys Asp Ala Cys 
                405                 410                 415     


Leu Lys Trp Arg Lys Leu Pro Asp Gly Met Asp Gln Leu Pro Glu Lys 
            420                 425                 430         


Trp Tyr Cys Ser Asn Asn Pro Asp Pro Gln Phe Arg Asn Cys Glu Val 
        435                 440                 445             


Pro Glu Glu Pro Glu Asp Glu Asp Leu Val His Pro Thr Tyr Glu Lys 
    450                 455                 460                 


Thr Tyr Lys Lys Thr Asn Lys Glu Lys Phe Arg Ile Arg Gln Pro Glu 
465                 470                 475                 480 


Met Ile Pro Arg Ile Asn Ala Glu Leu Leu Phe Arg Pro Thr Ala Leu 
                485                 490                 495     


Ser Thr Pro Ser Phe Ser Ser Pro Lys Glu Ser Val Pro Arg Arg His 
            500                 505                 510         


Leu Ser Glu Gly Thr Asn Ser Tyr Ala Thr Arg Leu Leu Asn Asn His 
        515                 520                 525             


Gln Val Pro Pro Gln Ser Glu Pro Glu Ser Asn Ser Leu Lys Arg Arg 
    530                 535                 540                 


Leu Ser Thr Arg Ser Ser Ile Leu Asn Ala Lys Asn Arg Arg Leu Ser 
545                 550                 555                 560 


Ser Gln Phe Glu Asn Ser Val Tyr Lys Gly Asp Asp Asp Asp Glu Asp 
                565                 570                 575     


Val Ile Ile Leu Glu Glu Asn Ser Thr Pro Lys Pro Ala Val Asp His 
            580                 585                 590         


Asp Ile Asp Met Lys Ser Glu Gln Ser His Val Glu Gln Gly Gly Val 
        595                 600                 605             


Gln Val Glu Phe Val Gly Asp Ser Glu Pro Cys Gly Gln Thr Gly Ser 
    610                 615                 620                 


Thr Ser Thr Ser Ser Ser Arg Cys Asp Gln Gly Asn Thr Ala Ala Thr 
625                 630                 635                 640 


Gln Thr Glu Val Pro Ser Leu Val Val Lys Lys Glu Glu Thr Val Glu 
                645                 650                 655     


Asp Glu Ile Asp Val Arg Asn Asp Ala Val Ile Leu Pro Ser Cys Val 
            660                 665                 670         


Glu Ala Glu Ala Lys Ile His Glu Thr Gln Glu Thr Thr Asp Lys Ser 
        675                 680                 685             


Ala Asp Asp Ala Gly Cys Gln Leu Gln Glu Leu Arg Asn Gln Leu Leu 
    690                 695                 700                 


Leu Val Thr Glu Glu Lys Glu Asn Tyr Lys Arg Gln Cys His Met Phe 
705                 710                 715                 720 


Thr Asp Gln Ile Lys Val Leu Gln Gln Arg Ile Leu Glu Met Asn Asp 
                725                 730                 735     


Lys Tyr Val Lys Lys Glu Thr Cys His Gln Ser Thr Glu Thr Asp Ala 
            740                 745                 750         


Val Phe Leu Leu Glu Ser Ile Asn Gly Lys Ser Glu Ser Pro Asp His 
        755                 760                 765             


Met Val Ser Gln Tyr Gln Gln Ala Leu Glu Glu Ile Glu Arg Leu Lys 
    770                 775                 780                 


Lys Gln Cys Ser Ala Leu Gln His Val Lys Ala Glu Cys Ser Gln Cys 
785                 790                 795                 800 


Ser Asn Asn Glu Ser Lys Ser Glu Met Asp Glu Met Ala Val Gln Leu 
                805                 810                 815     


Asp Asp Val Phe Arg Gln Leu Asp Lys Cys Ser Ile Glu Arg Asp Gln 
            820                 825                 830         


Tyr Lys Ser Glu Val Glu Leu Leu Glu Met Glu Lys Ser Gln Ile Arg 
        835                 840                 845             


Ser Gln Cys Glu Glu Leu Lys Thr Glu Val Glu Gln Leu Lys Ser Thr 
    850                 855                 860                 


Asn Gln Gln Thr Ala Thr Asp Val Ser Thr Ser Ser Asn Ile Glu Glu 
865                 870                 875                 880 


Ser Val Asn His Met Asp Gly Glu Ser Leu Lys Leu Arg Ser Leu Arg 
                885                 890                 895     


Val Asn Val Gly Gln Leu Leu Ala Met Ile Val Pro Asp Leu Asp Leu 
            900                 905                 910         


Gln Gln Val Asn Tyr Asp Val Asp Val Val Asp Glu Ile Leu Gly Gln 
        915                 920                 925             


Val Val Glu Gln Met Ser Glu Ile Ser Ser Thr 
    930                 935                 


<210>  799
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  799

Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 
1               5                   10                  15      


Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 
            20                  25                  30          


Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 
        35                  40                  45              


Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 
    50                  55                  60                  


Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 
65                  70                  75                  80  


Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 
                85                  90                  95      


Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 
            100                 105                 110         


Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 
        115                 120                 125             


Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 
    130                 135                 140                 


Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 
145                 150                 155                 160 


Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 
                165                 170                 175     


Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 
            180                 185                 190         


Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 
        195                 200                 205             


Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 
    210                 215                 220                 


Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 
225                 230                 235                 240 


Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 
                245                 250                 255     


Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 
            260                 265                 270         


Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 
        275                 280                 285             


Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 
    290                 295                 300                 


Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 
305                 310                 315                 320 


Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 
                325                 330                 335     


Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 
            340                 345                 350         


Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 
        355                 360                 365             


Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 
    370                 375                 380                 


Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 
385                 390                 395                 400 


Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 
                405                 410                 415     


Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 
            420                 425                 430         


Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 
        435                 440                 445             


Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 
    450                 455                 460                 


Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu Ser 
465                 470                 475                 480 


Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln Gln 
                485                 490                 495     


Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser Phe 
            500                 505                 510         


Phe Tyr Leu Leu Tyr Ser 
        515             


<210>  800
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  800

Met Ala Met Ile Glu Leu Gly Phe Gly Arg Gln Asn Phe His Pro Leu 
1               5                   10                  15      


Lys Arg Lys Ser Ser Leu Leu Leu Lys Leu Ile Ala Val Val Phe Ala 
            20                  25                  30          


Val Leu Leu Phe Cys Glu Phe Leu Ile Tyr Tyr Leu Ala Ile Phe Gln 
        35                  40                  45              


Cys Asn Trp Pro Glu Val Lys Thr Thr Ala Ser Asp Gly Glu Gln Thr 
    50                  55                  60                  


Thr Arg Glu Pro Val Leu Lys Ala Met Phe Leu Ala Asp Thr His Leu 
65                  70                  75                  80  


Leu Gly Glu Phe Leu Gly His Trp Leu Asp Lys Leu Arg Arg Glu Trp 
                85                  90                  95      


Gln Met Glu Arg Ala Phe Gln Thr Ala Leu Trp Leu Leu Gln Pro Glu 
            100                 105                 110         


Val Val Phe Ile Leu Gly Asp Ile Phe Asp Glu Gly Lys Trp Ser Thr 
        115                 120                 125             


Pro Glu Ala Trp Ala Asp Asp Val Glu Arg Phe Gln Lys Met Phe Arg 
    130                 135                 140                 


His Pro Ser His Val Gln Leu Lys Val Val Ala Gly Asn His Asp Ile 
145                 150                 155                 160 


Gly Phe His Tyr Glu Met Asn Thr Tyr Lys Val Glu Arg Phe Glu Lys 
                165                 170                 175     


Val Phe Ser Ser Glu Arg Leu Phe Ser Trp Lys Gly Ile Asn Phe Val 
            180                 185                 190         


Met Val Asn Ser Val Ala Leu Asn Gly Asp Gly Cys Gly Ile Cys Ser 
        195                 200                 205             


Glu Thr Glu Ala Glu Leu Ile Glu Val Ser His Arg Leu Asn Cys Ser 
    210                 215                 220                 


Arg Glu Ala Arg Gly Ser Ser Arg Cys Gly Pro Gly Pro Leu Leu Pro 
225                 230                 235                 240 


Thr Ser Ala Pro Val Leu Leu Gln His Tyr Pro Leu Tyr Arg Arg Ser 
                245                 250                 255     


Asp Ala Asn Cys Ser Gly Glu Asp Ala Ala Pro Ala Glu Glu Arg Asp 
            260                 265                 270         


Ile Pro Phe Lys Glu Asn Tyr Asp Val Leu Ser Arg Glu Ala Ser Gln 
        275                 280                 285             


Lys Leu Leu Trp Trp Leu Gln Pro Arg Leu Val Leu Ser Gly His Thr 
    290                 295                 300                 


His Ser Ala Cys Glu Val His His Gly Gly Arg Val Pro Glu Leu Ser 
305                 310                 315                 320 


Val Pro Ser Phe Ser Trp Arg Asn Arg Asn Asn Pro Ser Phe Ile Met 
                325                 330                 335     


Gly Ser Ile Thr Pro Thr Asp Tyr Thr Leu Ser Lys Cys Tyr Leu Pro 
            340                 345                 350         


Arg Glu Asp Val Val Leu Ile Ile Tyr Cys Gly Val Val Gly Phe Leu 
        355                 360                 365             


Val Val Leu Thr Leu Thr His Phe Gly Leu Leu Ala Ser Pro Phe Leu 
    370                 375                 380                 


Ser Gly Leu Asn Leu Leu Gly Lys Arg Lys Thr Arg 
385                 390                 395     


<210>  801
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  801

Met Glu Arg Arg Met Gln Leu Val Lys Lys Asp Asn Glu Lys Glu Arg 
1               5                   10                  15      


His Lys Leu Phe Gln Gly Tyr Glu Thr Glu Glu Arg Glu Glu Thr Glu 
            20                  25                  30          


Leu Ser Glu Lys Ile Lys Leu Glu Cys Gln Pro Glu Leu Ser Glu Thr 
        35                  40                  45              


Ser Gln Thr Leu Pro Pro Lys Pro Phe Ser Cys Gly Arg Ser Gly Lys 
    50                  55                  60                  


Gly His Lys Arg Lys Ser Pro Phe Gly Ser Thr Glu Arg Lys Thr Pro 
65                  70                  75                  80  


Val Lys Lys Leu Ala Pro Glu Phe Ser Lys Val Lys Thr Lys Thr Pro 
                85                  90                  95      


Lys His Ser Pro Ile Lys Glu Glu Pro Cys Gly Ser Leu Ser Glu Thr 
            100                 105                 110         


Val Cys Lys Arg Glu Leu Arg Ser Gln Glu Thr Pro Glu Lys Pro Arg 
        115                 120                 125             


Ser Ser Val Asp Thr Pro Pro Arg Leu Ser Thr Pro Gln Lys Gly Pro 
    130                 135                 140                 


Ser Thr His Pro Lys Glu Lys Ala Phe Ser Ser Glu Ile Glu Asp Leu 
145                 150                 155                 160 


Pro Tyr Leu Ser Thr Thr Glu Met Tyr Leu Cys Arg Trp His Gln Pro 
                165                 170                 175     


Pro Pro Ser Pro Leu Pro Leu Arg Glu Ser Ser Pro Lys Lys Glu Glu 
            180                 185                 190         


Thr Val Ala Arg Cys Leu Met Pro Ser Ser Val Ala Gly Glu Thr Ser 
        195                 200                 205             


Val Leu Ala Val Pro Ser Trp Arg Asp His Ser Val Glu Pro Leu Arg 
    210                 215                 220                 


Asp Pro Asn Pro Ser Asp Leu Leu Glu Asn Leu Asp Asp Ser Val Phe 
225                 230                 235                 240 


Ser Lys Arg His Ala Lys Leu Glu Leu Asp Glu Lys Arg Arg Lys Arg 
                245                 250                 255     


Trp Asp Ile Gln Arg Ile Arg Glu Gln Arg Ile Leu Gln Arg Leu Gln 
            260                 265                 270         


Leu Arg Met Tyr Lys Lys Lys Gly Ile Gln Glu Ser Glu Pro Glu Val 
        275                 280                 285             


Thr Ser Phe Phe Pro Glu Pro Asp Asp Val Glu Ser Leu Met Ile Thr 
    290                 295                 300                 


Pro Phe Leu Pro Val Val Ala Phe Gly Arg Pro Leu Pro Lys Leu Thr 
305                 310                 315                 320 


Pro Gln Asn Phe Glu Leu Pro Trp Leu Asp Glu Arg Ser Arg Cys Arg 
                325                 330                 335     


Leu Glu Ile Gln Lys Lys Gln Thr Pro His Arg Thr Cys Arg Lys 
            340                 345                 350     


<210>  802
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  802

Met Asp Glu Glu Thr Arg His Ser Leu Glu Cys Ile Gln Ala Asn Gln 
1               5                   10                  15      


Ile Phe Pro Arg Lys Gln Leu Ile Arg Glu Asp Glu Asn Leu Gln Val 
            20                  25                  30          


Pro Phe Leu Glu Leu His Gly Glu Ser Thr Glu Phe Val Gly Arg Ala 
        35                  40                  45              


Glu Asp Ala Ile Ile Ala Leu Ser Asn Tyr Arg Leu His Ile Lys Phe 
    50                  55                  60                  


Lys Glu Ser Leu Val Asn Val Pro Leu Gln Leu Ile Glu Ser Val Glu 
65                  70                  75                  80  


Cys Arg Asp Ile Phe Gln Leu His Leu Thr Cys Lys Asp Cys Lys Val 
                85                  90                  95      


Ile Arg Cys Gln Phe Ser Thr Phe Glu Gln Cys Gln Glu Trp Leu Lys 
            100                 105                 110         


Arg Leu Asn Asn Ala Ile Arg Pro Pro Ala Lys Ile Glu Asp Leu Phe 
        115                 120                 125             


Ser Phe Ala Tyr His Ala Trp Cys Met Glu Val Tyr Ala Ser Glu Lys 
    130                 135                 140                 


Glu Gln His Gly Asp Leu Cys Arg Pro Gly Glu His Val Thr Ser Arg 
145                 150                 155                 160 


Phe Lys Asn Glu Val Glu Arg Met Gly Phe Asp Met Asn Asn Ala Trp 
                165                 170                 175     


Arg Ile Ser Asn Ile Asn Glu Lys Tyr Lys Leu Cys Gly Ser Tyr Pro 
            180                 185                 190         


Gln Glu Leu Ile Val Pro Ala Trp Ile Thr Asp Lys Glu Leu Glu Ser 
        195                 200                 205             


Val Ser Ser Phe Arg Ser Trp Lys Arg Ile Pro Ala Val Ile Tyr Arg 
    210                 215                 220                 


His Gln Ser Asn Gly Ala Val Ile Ala Arg Cys Gly Gln Pro Glu Val 
225                 230                 235                 240 


Ser Trp Trp Gly Trp Arg Asn Ala Asp Asp Glu His Leu Val Gln Ser 
                245                 250                 255     


Val Ala Lys Ala Cys Ala Ser Asp Ser Arg Ser Ser Gly Ser Lys Leu 
            260                 265                 270         


Ser Thr Arg Asn Thr Ser Arg Asp Phe Pro Asn Gly Gly Asp Leu Ser 
        275                 280                 285             


Asp Val Glu Phe Asp Ser Ser Leu Ser Asn Ala Ser Gly Ala Glu Ser 
    290                 295                 300                 


Leu Ala Ile Gln Pro Gln Lys Leu Leu Ile Leu Asp Ala Arg Ser Tyr 
305                 310                 315                 320 


Ala Ala Ala Val Ala Asn Arg Ala Lys Gly Gly Gly Cys Glu Cys Pro 
                325                 330                 335     


Glu Tyr Tyr Pro Asn Cys Glu Val Val Phe Met Gly Met Ala Asn Ile 
            340                 345                 350         


His Ser Ile Arg Arg Ser Phe Gln Ser Leu Arg Leu Leu Cys Thr Gln 
        355                 360                 365             


Met Pro Asp Pro Gly Asn Trp Leu Ser Ala Leu Glu Ser Thr Lys Trp 
    370                 375                 380                 


Leu His His Leu Ser Val Leu Leu Lys Ser Ala Leu Leu Val Val His 
385                 390                 395                 400 


Ala Val Asp Gln Asp Gln Arg Pro Val Leu Val His Cys Ser Asp Gly 
                405                 410                 415     


Trp Asp Arg Thr Pro Gln Ile Val Ala Leu Ala Lys Leu Leu Leu Asp 
            420                 425                 430         


Pro Tyr Tyr Arg Thr Ile Glu Gly Phe Gln Val Leu Val Glu Met Glu 
        435                 440                 445             


Trp Leu Asp Phe Gly His Lys Phe Ala Asp Arg Cys Gly His Gly Glu 
    450                 455                 460                 


Asn Ser Asp Asp Leu Asn Glu Arg Cys Pro Val Phe Leu Gln Trp Leu 
465                 470                 475                 480 


Asp Cys Val His Gln Leu Gln Arg Gln Phe Pro Cys Ser Phe Glu Phe 
                485                 490                 495     


Asn Glu Ala Phe Leu Val Lys Leu Val Gln His Thr Tyr Ser Cys Leu 
            500                 505                 510         


Phe Gly Thr Phe Leu Cys Asn Asn Ala Lys Glu Arg Gly Glu Lys His 
        515                 520                 525             


Thr Gln Glu Arg Thr Cys Ser Val Trp Ser Leu Leu Arg Ala Gly Asn 
    530                 535                 540                 


Lys Ala Phe Lys Asn Leu Leu Tyr Ser Ser Gln Ser Glu Ala Val Leu 
545                 550                 555                 560 


Tyr Pro Val Cys His Val Arg Asn Leu Met Leu Trp Ser Ala Val Tyr 
                565                 570                 575     


Leu Pro Cys Pro Ser Pro Thr Thr Pro Val Asp Asp Ser Cys Ala Pro 
            580                 585                 590         


Tyr Pro Ala Pro Gly Thr Ser Pro Asp Asp Pro Pro Leu Ser Arg Leu 
        595                 600                 605             


Pro Lys Thr Arg Ser Tyr Asp Asn Leu Thr Thr Ala Cys Asp Asn Thr 
    610                 615                 620                 


Val Pro Leu Ala Ser Arg Arg Cys Ser Asp Pro Ser Leu Asn Glu Lys 
625                 630                 635                 640 


Trp Gln Glu His Arg Arg Ser Leu Glu Leu Ser Ser Leu Ala Gly Pro 
                645                 650                 655     


Gly Glu Asp Pro Leu Ser Ala Asp Ser Leu Gly Lys Pro Thr Arg Val 
            660                 665                 670         


Pro Gly Gly Ala Glu Leu Ser Val Ala Ala Gly Val Ala Glu Gly Gln 
        675                 680                 685             


Met Glu Asn Ile Leu Gln Glu Ala Thr Lys Glu Glu Ser Gly Val Glu 
    690                 695                 700                 


Glu Pro Ala His Arg Ala Gly Ile Glu Ile Gln Glu Gly Lys Glu Asp 
705                 710                 715                 720 


Pro Leu Leu Glu Lys Glu Ser Arg Arg Lys Thr Pro Glu Ala Ser Ala 
                725                 730                 735     


Ile Gly Leu His Gln Asp Pro Glu Leu Gly Asp Ala Ala Leu Arg Ser 
            740                 745                 750         


His Leu Asp Met Ser Trp Pro Leu Phe Ser Gln Gly Ile Ser Glu Gln 
        755                 760                 765             


Gln Ser Gly Leu Ser Val Leu Leu Ser Ser Leu Gln Val Pro Pro Arg 
    770                 775                 780                 


Gly Glu Asp Ser Leu Glu Val Pro Val Glu Gln Phe Arg Ile Glu Glu 
785                 790                 795                 800 


Ile Ala Glu Gly Arg Glu Glu Ala Val Leu Pro Ile Pro Val Asp Ala 
                805                 810                 815     


Lys Val Gly Tyr Gly Thr Ser Gln Ser Cys Ser Leu Leu Pro Ser Gln 
            820                 825                 830         


Val Pro Phe Glu Thr Arg Gly Pro Asn Val Asp Ser Ser Thr Asp Met 
        835                 840                 845             


Leu Val Glu Asp Lys Val Lys Ser Val Ser Gly Pro Gln Gly His His 
    850                 855                 860                 


Arg Ser Cys Leu Val Asn Ser Gly Lys Asp Arg Leu Pro Gln Thr Met 
865                 870                 875                 880 


Glu Pro Ser Pro Ser Glu Thr Ser Leu Val Glu Arg Pro Gln Val Gly 
                885                 890                 895     


Ser Val Val His Arg Thr Ser Leu Gly Ser Thr Leu Ser Leu Thr Arg 
            900                 905                 910         


Ser Pro Cys Ala Leu Pro Leu Ala Glu Cys Lys Glu Gly Leu Val Cys 
        915                 920                 925             


Asn Gly Ala Pro Glu Thr Glu Asn Arg Ala Ser Glu Gln Pro Pro Gly 
    930                 935                 940                 


Leu Ser Thr Leu Gln Met Tyr Pro Thr Pro Asn Gly His Cys Ala Asn 
945                 950                 955                 960 


Gly Glu Ala Gly Arg Ser Lys Asp Ser Leu Ser Arg Gln Leu Ser Ala 
                965                 970                 975     


Met Ser Cys Ser Ser Ala His Leu His Ser Arg Asn Leu His His Lys 
            980                 985                 990         


Trp Leu His Ser His Ser Gly Arg  Pro Ser Ala Thr Ser  Ser Pro Asp 
        995                 1000                 1005             


Gln Pro  Ser Arg Ser His Leu  Asp Asp Asp Gly Met  Ser Val Tyr 
    1010                 1015                 1020             


Thr Asp  Thr Ile Gln Gln Arg  Leu Arg Gln Ile Glu  Ser Gly His 
    1025                 1030                 1035             


Gln Gln  Glu Val Glu Thr Leu  Lys Lys Gln Val Gln  Glu Leu Lys 
    1040                 1045                 1050             


Ser Arg  Leu Glu Ser Gln Tyr  Leu Thr Ser Ser Leu  His Phe Asn 
    1055                 1060                 1065             


Gly Asp  Phe Gly Asp Glu Val  Thr Ser Ile Pro Asp  Ser Glu Ser 
    1070                 1075                 1080             


Asn Leu  Asp Gln Asn Cys Leu  Ser Arg Cys Ser Thr  Glu Ile Phe 
    1085                 1090                 1095             


Ser Glu  Ala Ser Trp Glu Gln  Val Asp Lys Gln Asp  Thr Glu Met 
    1100                 1105                 1110             


Thr Arg  Trp Leu Pro Asp His  Leu Ala Ala His Cys  Tyr Ala Cys 
    1115                 1120                 1125             


Asp Ser  Ala Phe Trp Leu Ala  Ser Arg Lys His His  Cys Arg Asn 
    1130                 1135                 1140             


Cys Gly  Asn Val Phe Cys Ser  Ser Cys Cys Asn Gln  Lys Val Pro 
    1145                 1150                 1155             


Val Pro  Ser Gln Gln Leu Phe  Glu Pro Ser Arg Val  Cys Lys Ser 
    1160                 1165                 1170             


Cys Tyr  Ser Ser Leu His Pro  Thr Ser Ser Ser Ile  Asp Leu Glu 
    1175                 1180                 1185             


Leu Asp  Lys Pro Ile Ala Ala  Thr Ser Asn 
    1190                 1195             


<210>  803
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  803

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  804
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  804

Met Glu Arg Val Lys Met Ile Asn Val Gln Arg Leu Leu Glu Ala Ala 
1               5                   10                  15      


Glu Phe Leu Glu Arg Arg Glu Arg Glu Cys Glu His Gly Tyr Ala Ser 
            20                  25                  30          


Ser Phe Pro Ser Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro 
        35                  40                  45              


Arg Arg Leu Ser Arg Ala Gln Lys His Ser Ser Gly Ser Ser Asn Thr 
    50                  55                  60                  


Ser Thr Ala Asn Arg Ser Thr His Asn Glu Leu Glu Lys Asn Arg Arg 
65                  70                  75                  80  


Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile Pro Leu 
                85                  90                  95      


Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn Lys Ala 
            100                 105                 110         


Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser Gln His 
        115                 120                 125             


Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Trp Arg Leu 
    130                 135                 140                 


Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met Asp Ser 
145                 150                 155                 160 


Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg Glu Glu 
                165                 170                 175     


Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu Val Asp 
            180                 185                 190         


Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser Ser Leu 
        195                 200                 205             


Pro Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val Lys Leu 
    210                 215                 220                 


Ser Phe Thr Ser 
225             


<210>  805
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  805

Leu Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  806
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  806

Met Ala Ala Arg Ala Val Leu Asp Glu Phe Thr Ala Pro Ala Glu Lys 
1               5                   10                  15      


Ala Glu Leu Leu Glu Gln Ser Arg Gly Arg Ile Glu Gly Leu Phe Gly 
            20                  25                  30          


Val Ser Leu Ala Val Leu Gly Ala Leu Gly Ala Glu Glu Pro Leu Pro 
        35                  40                  45              


Ala Arg Ile Trp Leu Gln Leu Cys Gly Ala Gln Glu Ala Val His Ser 
    50                  55                  60                  


Ala Lys Glu Tyr Ile Lys Gly Ile Cys Glu Pro Glu Leu Glu Glu Arg 
65                  70                  75                  80  


Glu Cys Tyr Pro Lys Asp Met His Cys Ile Phe Val Gly Ala Glu Ser 
                85                  90                  95      


Leu Phe Leu Lys Ser Leu Ile Gln Asp Thr Cys Ala Asp Leu Cys Ile 
            100                 105                 110         


Leu Asp Ile Gly Leu Leu Gly Ile Arg Gly Ser Ala Glu Ala Val Val 
        115                 120                 125             


Met Ala Arg Ser His Ile Gln Gln Phe Val Lys Leu Phe Glu Asn Lys 
    130                 135                 140                 


Glu Asn Leu Pro Ser Ser Gln Lys Glu Ser Glu Val Lys Arg Glu Phe 
145                 150                 155                 160 


Lys Gln Phe Val Glu Ala His Ala Asp Asn Tyr Thr Met Asp Leu Leu 
                165                 170                 175     


Ile Leu Pro Thr Ser Leu Lys Lys Glu Leu Leu Thr Leu Thr Gln Gly 
            180                 185                 190         


Glu Glu Asn Leu Phe Glu Thr Gly Asp Asp Glu Val Ile Glu Met Arg 
        195                 200                 205             


Asp Ser Gln Gln Thr Glu Phe Thr Gln Asn Ala Ala Thr Gly Leu Asn 
    210                 215                 220                 


Ile Ser Arg Asp Glu Thr Val Leu Gln Glu Glu Ala Arg Asn Lys Ala 
225                 230                 235                 240 


Gly Thr Pro Val Ser Glu Leu Thr Lys Gln Met Asp Thr Val Leu Ser 
                245                 250                 255     


Ser Ser Pro Asp Val Leu Phe Asp Pro Ile Asn Gly Leu Thr Pro Asp 
            260                 265                 270         


Glu Glu Ala Leu Ser Asn Glu Arg Ile Cys Gln Lys Arg Arg Phe Ser 
        275                 280                 285             


Asp Ser Glu Glu Arg His Thr Lys Lys Gln Phe Ser Leu Glu Asn Val 
    290                 295                 300                 


Gln Glu Gly Glu Ile Leu His Asp Ala Lys Thr Leu Ala Gly Asn Val 
305                 310                 315                 320 


Ile Ala Asp Leu Ser Asp Ser Ser Ala Asp Ser Glu Asn Leu Ser Pro 
                325                 330                 335     


Asp Ile Lys Glu Thr Thr Glu Glu Met Glu Tyr Asn Ile Leu Val Asn 
            340                 345                 350         


Phe Phe Lys Thr Met Gly Tyr Ser Gln Glu Ile Val Glu Lys Val Ile 
        355                 360                 365             


Lys Val Tyr Gly Pro Ser Thr Glu Pro Leu Leu Leu Leu Glu Glu Ile 
    370                 375                 380                 


Glu Lys Glu Asn Lys Arg Phe Gln Glu Asp Arg Glu Phe Ser Ala Gly 
385                 390                 395                 400 


Thr Val Tyr Pro Glu Thr Asn Lys Thr Lys Asn Lys Gly Val Tyr Ser 
                405                 410                 415     


Ser Thr Asn Glu Leu Thr Thr Asp Ser Thr Pro Lys Lys Thr Gln Ala 
            420                 425                 430         


His Thr Gln Gln Asn Met Val Glu Lys Phe Ser Gln Leu Pro Phe Lys 
        435                 440                 445             


Val Glu Ala Lys Pro Cys Thr Ser Asn Cys Arg Ile Asn Thr Phe Arg 
    450                 455                 460                 


Thr Val Pro Ile Glu Gln Lys His Glu Val Trp Gly Ser Asn Gln Asn 
465                 470                 475                 480 


Tyr Ile Cys Asn Thr Asp Pro Glu Thr Asp Gly Leu Ser Pro Ser Val 
                485                 490                 495     


Ala Ser Pro Ser Pro Lys Glu Val Asn Phe Val Ser Arg Gly Ala Ser 
            500                 505                 510         


Ser His Gln Pro Arg Val Pro Leu Phe Pro Glu Asn Gly Leu His Gln 
        515                 520                 525             


Gln Pro Glu Pro Leu Leu Pro Asn Asn Met Lys Ser Ala Cys Glu Lys 
    530                 535                 540                 


Arg Leu Gly Cys Cys Ser Ser Pro His Ser Lys Pro Asn Cys Ser Thr 
545                 550                 555                 560 


Leu Ser Pro Pro Met Pro Leu Pro Gln Leu Leu Pro Ser Val Thr Asp 
                565                 570                 575     


Ala Arg Ser Ala Gly Pro Ser Asp His Ile Asp Ser Ser Val Thr Gly 
            580                 585                 590         


Val Gln Arg Phe Arg Asp Thr Leu Lys Ile Pro Tyr Lys Leu Glu Leu 
        595                 600                 605             


Lys Asn Glu Pro Gly Arg Thr Asp Leu Lys His Ile Val Ile Asp Gly 
    610                 615                 620                 


Ser Asn Val Ala Ile Thr His Gly Leu Lys Lys Phe Phe Ser Cys Arg 
625                 630                 635                 640 


Gly Ile Ala Ile Ala Val Glu Tyr Phe Trp Lys Leu Gly Asn Arg Asn 
                645                 650                 655     


Ile Thr Val Phe Val Pro Gln Trp Arg Thr Arg Arg Asp Pro Asn Val 
            660                 665                 670         


Thr Glu Gln His Phe Leu Thr Gln Leu Gln Glu Leu Gly Ile Leu Ser 
        675                 680                 685             


Leu Thr Pro Ala Arg Met Val Phe Gly Glu Arg Ile Ala Ser His Asp 
    690                 695                 700                 


Asp Arg Phe Leu Leu His Leu Ala Asp Lys Thr Gly Gly Ile Ile Val 
705                 710                 715                 720 


Thr Asn Asp Asn Phe Arg Glu Phe Val Asn Glu Ser Val Ser Trp Arg 
                725                 730                 735     


Glu Ile Ile Thr Lys Arg Leu Leu Gln Tyr Thr Phe Val Gly Asp Ile 
            740                 745                 750         


Phe Met Val Pro Asp Asp Pro Leu Gly Arg Ser Gly Pro Arg Leu Glu 
        755                 760                 765             


Glu Phe Leu Gln Lys Glu Val Cys Leu Arg Asp Met Gln Pro Leu Leu 
    770                 775                 780                 


Ser Ala Leu Pro Asn Val Gly Met Phe Asp Pro Ser Phe Arg Val Pro 
785                 790                 795                 800 


Gly Thr Gln Ala Ala Ser Thr Ser His Gln Pro Pro Thr Arg Ile Gln 
                805                 810                 815     


Gly Ala Pro Ser Ser His Trp Leu Pro Gln Gln Pro His Phe Pro Leu 
            820                 825                 830         


Leu Pro Ala Leu Pro Ser Leu Gln Gln Asn Leu Pro Met Pro Ala Gln 
        835                 840                 845             


Arg Ser Ser Ala Glu Thr Asn Glu Leu Arg Glu Ala Leu Leu Lys Ile 
    850                 855                 860                 


Phe Pro Asp Ser Glu Gln Arg Leu Lys Ile Asp Gln Ile Leu Val Ala 
865                 870                 875                 880 


His Pro Tyr Met Lys Asp Leu Asn Ala Leu Ser Ala Met Val Leu Asp 
                885                 890                 895     


<210>  807
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  807

Met Ala Ala Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg 
1               5                   10                  15      


Ile Leu Gln Lys Ala Asn Leu Leu Ser Tyr Phe Asp Ala Phe Ile Gln 
            20                  25                  30          


Gln Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu 
        35                  40                  45              


Phe Leu Glu Ile Met Ala Leu Val Gly Met Ala Ser Lys Pro Leu His 
    50                  55                  60                  


Val Arg Arg Leu Gln Lys Ala Leu Arg Asp Trp Val Thr Asn Pro Gly 
65                  70                  75                  80  


Leu Phe Asn Gln Pro Leu Thr Ser Leu Pro Val Ser Ser Ile Pro Ile 
                85                  90                  95      


Tyr Lys Leu Pro Glu Gly Ser Pro Thr Trp Leu Gly Ile Ser Cys Ser 
            100                 105                 110         


Ser Tyr Glu Arg Ser Ser Asn Ala Arg Glu Pro His Leu Lys Ile Pro 
        115                 120                 125             


Lys Cys Ala Ala Thr Thr Cys Val Gln Ser Leu Gly Gln Gly Lys Ser 
    130                 135                 140                 


Asp Val Val Gly Ser Leu Ala Leu Gln Ser Val Gly Glu Ser Arg Leu 
145                 150                 155                 160 


Trp Gln Gly His His Ala Thr Glu Ser Glu His Ser Leu Ser Pro Ala 
                165                 170                 175     


Asp Leu Gly Ser Pro Ala Ser Pro Lys Glu Ser Ser Glu Ala Leu Asp 
            180                 185                 190         


Ala Ala Ala Ala Leu Ser Val Ala Glu Cys Val Glu Arg Met Ala Pro 
        195                 200                 205             


Thr Leu Pro Lys Ser Asp Leu Asn Glu Val Lys Glu Leu Leu Lys Thr 
    210                 215                 220                 


Asn Lys Lys Leu Ala Lys Met Ile Gly His Ile Phe Glu Met Asn Asp 
225                 230                 235                 240 


Asp Asp Pro His Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ala Ile Tyr 
                245                 250                 255     


Gly Arg Phe Asp Ser Lys Arg Lys Asp Gly Lys His Leu Thr Leu His 
            260                 265                 270         


Glu Leu Thr Val Asn Glu Ala Ala Ala Gln Leu Cys Val Lys Asp Asn 
        275                 280                 285             


Ala Leu Leu Thr Arg Arg Asp Glu Leu Phe Ala Leu Ala Arg Gln Ile 
    290                 295                 300                 


Ser Arg Glu Val Thr Tyr Lys Tyr Thr Tyr Arg Thr Thr Lys Ser Lys 
305                 310                 315                 320 


Cys Gly Glu Arg Asp Glu Leu Ser Pro Lys Arg Ile Lys Val Glu Asp 
                325                 330                 335     


Gly Phe Pro Asp Phe Gln Asp Ser Val Gln Thr Leu Phe Gln Gln Ala 
            340                 345                 350         


Arg Ala Lys Ser Glu Glu Leu Ala Ala Leu Ser Ser Gln Gln Pro Glu 
        355                 360                 365             


Lys Val Met Ala Lys Gln Met Glu Phe Leu Cys Asn Gln Ala Gly Tyr 
    370                 375                 380                 


Glu Arg Leu Gln His Ala Glu Arg Arg Leu Ser Ala Gly Leu Tyr Arg 
385                 390                 395                 400 


Gln Ser Ser Glu Glu His Ser Pro Asn Gly Leu Thr Ser Asp Asn Ser 
                405                 410                 415     


Asp Gly Gln Gly Glu Arg Pro Leu Asn Leu Arg Met Pro Asn Leu Gln 
            420                 425                 430         


Asn Arg Gln Pro His His Phe Val Val Asp Gly Glu Leu Ser Arg Leu 
        435                 440                 445             


Tyr Pro Ser Glu Ala Lys Ser His Ser Ser Glu Ser Leu Gly Ile Leu 
    450                 455                 460                 


Lys Asp Tyr Pro His Ser Ala Phe Thr Leu Glu Lys Lys Val Ile Lys 
465                 470                 475                 480 


Thr Glu Pro Glu Asp Ser Arg 
                485         


<210>  808
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  808

Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 
1               5                   10                  15      


Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 
            20                  25                  30          


Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 
        35                  40                  45              


Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 
    50                  55                  60                  


Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 
65                  70                  75                  80  


Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 
                85                  90                  95      


Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 
            100                 105                 110         


Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 
        115                 120                 125             


Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 
    130                 135                 140                 


Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 
145                 150                 155                 160 


Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 
                165                 170                 175     


Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 
            180                 185                 190         


Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 
        195                 200                 205             


Ala Ile Met Glu Leu Thr Met 
    210                 215 


<210>  809
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  809

Met Ser Gly Gly Leu Leu Lys Ala Leu Arg Ser Asp Ser Tyr Val Glu 
1               5                   10                  15      


Leu Ser Gln Tyr Arg Asp Gln His Phe Arg Gly Asp Asn Glu Glu Gln 
            20                  25                  30          


Glu Lys Leu Leu Lys Lys Ser Cys Thr Leu Tyr Val Gly Asn Leu Ser 
        35                  40                  45              


Phe Tyr Thr Thr Glu Glu Gln Ile Tyr Glu Leu Phe Ser Lys Ser Gly 
    50                  55                  60                  


Asp Ile Lys Lys Ile Ile Met Gly Leu Asp Lys Met Lys Lys Thr Ala 
65                  70                  75                  80  


Cys Gly Phe Cys Phe Val Glu Tyr Tyr Ser Arg Ala Asp Ala Glu Asn 
                85                  90                  95      


Ala Met Arg Tyr Ile Asn Gly Thr Arg Leu Asp Asp Arg Ile Ile Arg 
            100                 105                 110         


Thr Asp Trp Asp Ala Gly Phe Lys Glu Gly Arg Gln Tyr Gly Arg Gly 
        115                 120                 125             


Arg Ser Gly Gly Gln Val Arg Asp Glu Tyr Arg Gln Asp Tyr Asp Ala 
    130                 135                 140                 


Gly Arg Gly Gly Tyr Gly Lys Leu Ala Gln Asn Gln 
145                 150                 155     


<210>  810
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  810

Met Ser Gly Leu Gly Asp Ser Ser Ser Asp Pro Ala Asn Pro Asp Ser 
1               5                   10                  15      


His Lys Arg Lys Gly Ser Pro Cys Asp Thr Leu Ala Ser Ser Thr Glu 
            20                  25                  30          


Lys Arg Arg Arg Glu Gln Glu Asn Lys Tyr Leu Glu Glu Leu Ala Glu 
        35                  40                  45              


Leu Leu Ser Ala Asn Ile Ser Asp Ile Asp Ser Leu Ser Val Lys Pro 
    50                  55                  60                  


Asp Lys Cys Lys Ile Leu Lys Lys Thr Val Asp Gln Ile Gln Leu Met 
65                  70                  75                  80  


Lys Arg Met Glu Gln Glu Lys Ser Thr Thr Asp Asp Asp Val Gln Lys 
                85                  90                  95      


Ser Asp Ile Ser Ser Ser Ser Gln Gly Val Ile Glu Lys Glu Ser Leu 
            100                 105                 110         


Gly Pro Leu Leu Leu Glu Ala Leu Asp Gly Phe Phe Phe Val Val Asn 
        115                 120                 125             


Cys Glu Gly Arg Ile Val Phe Val Ser Glu Asn Val Thr Ser Tyr Leu 
    130                 135                 140                 


Gly Tyr Asn Gln Glu Glu Leu Met Asn Thr Ser Val Tyr Ser Ile Leu 
145                 150                 155                 160 


His Val Gly Asp His Ala Glu Phe Val Lys Asn Leu Leu Pro Lys Ser 
                165                 170                 175     


Leu Val Asn Gly Val Pro Trp Pro Gln Glu Ala Thr Arg Arg Asn Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Ile His Pro Pro Asp Glu Pro Gly 
        195                 200                 205             


Thr Glu Asn Gln Glu Ala Cys Gln Arg Tyr Glu Val Met Gln Cys Phe 
    210                 215                 220                 


Thr Val Ser Gln Pro Lys Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln 
225                 230                 235                 240 


Ser Cys Leu Ile Cys Ile Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile 
                245                 250                 255     


Thr Gly Val Glu Ser Phe Met Thr Lys Gln Asp Thr Thr Gly Lys Ile 
            260                 265                 270         


Ile Ser Ile Asp Thr Ser Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp 
        275                 280                 285             


Glu Asp Leu Val Arg Lys Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly 
    290                 295                 300                 


Arg Glu Pro Ser Tyr Ala Arg Gln Leu Phe Gln Glu Val Met Thr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Ser Pro Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr 
                325                 330                 335     


Met Leu Ser Ala His Thr Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro 
            340                 345                 350         


Asp Met Gln Pro Phe Ile Met Gly Ile His Ile Ile Asp Arg Glu His 
        355                 360                 365             


Ser Gly Leu Ser Pro Gln Asp Asp Thr Asn Ser Gly Met Ser Ile Pro 
    370                 375                 380                 


Arg Val Asn Pro Ser Val Asn Pro Ser Ile Ser Pro Ala His Gly Val 
385                 390                 395                 400 


Ala Arg Ser Ser Thr Leu Pro Pro Ser Asn Ser Asn Met Val Ser Thr 
                405                 410                 415     


Arg Ile Asn Arg Gln Gln Ser Ser Asp Leu His Ser Ser Ser His Ser 
            420                 425                 430         


Asn Ser Ser Asn Ser Gln Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln 
        435                 440                 445             


Ile Val Ala Asn Val Ala Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser 
    450                 455                 460                 


Ser Asn Pro Ser Leu Asn Leu Asn Asn Ser Pro Met Glu Gly Thr Gly 
465                 470                 475                 480 


Ile Ser Leu Ala Gln Phe Met Ser Pro Arg Arg Gln Val Thr Ser Gly 
                485                 490                 495     


Leu Ala Thr Arg Pro Arg Met Pro Asn Asn Ser Phe Pro Pro Asn Ile 
            500                 505                 510         


Ser Thr Leu Ser Ser Pro Val Gly Met Thr Ser Ser Ala Cys Asn Asn 
        515                 520                 525             


Asn Asn Arg Ser Tyr Ser Asn Ile Pro Val Thr Ser Leu Gln Gly Met 
    530                 535                 540                 


Asn Glu Gly Pro Asn Asn Ser Val Gly Phe Ser Ala Ser Ser Pro Val 
545                 550                 555                 560 


Leu Arg Gln Met Ser Ser Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln 
                565                 570                 575     


Pro Ala Lys Ala Glu Ser Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu 
            580                 585                 590         


Asn Glu Met Ile Gln Ser Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu 
        595                 600                 605             


Asp Ser Gly Leu Leu His Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser 
    610                 615                 620                 


Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
625                 630                 635                 640 


Ala Glu Gln Gln Leu Arg His Ala Asp Ile Asp Thr Ser Cys Lys Asp 
                645                 650                 655     


Val Leu Ser Cys Thr Gly Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser 
            660                 665                 670         


Gly Gly Ser Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr 
    690                 695                 700                 


Leu Ser Val Glu Pro Asp Lys Lys Asp Ser Ala Ser Thr Ser Val Ser 
705                 710                 715                 720 


Val Thr Gly Gln Val Gln Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp 
                725                 730                 735     


Ala Ser Lys Lys Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu 
            740                 745                 750         


Leu Asp Lys Asp Glu Lys Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu 
        755                 760                 765             


Asp Asp Val Lys Val Lys Val Glu Lys Lys Glu Gln Met Asp Pro Cys 
    770                 775                 780                 


Asn Thr Asn Pro Thr Pro Met Thr Lys Pro Thr Pro Glu Glu Ile Lys 
785                 790                 795                 800 


Leu Glu Ala Gln Ser Gln Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln 
                805                 810                 815     


Leu Leu Pro Thr Leu Glu Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu 
            820                 825                 830         


Thr Asp Arg Met Asp Gly Ala Val Thr Ser Val Thr Ile Lys Ser Glu 
        835                 840                 845             


Ile Leu Pro Ala Ser Leu Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg 
    850                 855                 860                 


Leu Asn Arg Leu Pro Glu Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe 
865                 870                 875                 880 


Gly Gln Pro Gly Thr Gly Asp Gln Ile Pro Trp Thr Asn Asn Thr Val 
                885                 890                 895     


Thr Ala Ile Asn Gln Ser Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln 
            900                 905                 910         


Leu Asp Glu Leu Leu Cys Pro Pro Thr Thr Val Glu Gly Arg Asn Asp 
        915                 920                 925             


Glu Lys Ala Leu Leu Glu Gln Leu Val Ser Phe Leu Ser Gly Lys Asp 
    930                 935                 940                 


Glu Thr Glu Leu Ala Glu Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu 
945                 950                 955                 960 


Val Gln Gly Gly Gly Leu Asp Val Leu Ser Glu Arg Phe Pro Pro Gln 
                965                 970                 975     


Gln Ala Thr Pro Pro Leu Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser 
            980                 985                 990         


Gln Pro Tyr Ser Ser Pro Ser Pro  Thr Ala Asn Leu Pro  Ser Pro Phe 
        995                 1000                 1005             


Gln Gly  Met Val Arg Gln Lys  Pro Ser Leu Gly Thr  Met Pro Val 
    1010                 1015                 1020             


Gln Val  Thr Pro Pro Arg Gly  Ala Phe Ser Pro Gly  Met Gly Met 
    1025                 1030                 1035             


Gln Pro  Arg Gln Thr Leu Asn  Arg Pro Pro Ala Ala  Pro Asn Gln 
    1040                 1045                 1050             


Leu Arg  Leu Gln Leu Gln Gln  Arg Leu Gln Gly Gln  Gln Gln Leu 
    1055                 1060                 1065             


Ile His  Gln Asn Arg Gln Ala  Ile Leu Asn Gln Phe  Ala Ala Thr 
    1070                 1075                 1080             


Ala Pro  Val Gly Ile Asn Met  Arg Ser Gly Met Gln  Gln Gln Ile 
    1085                 1090                 1095             


Thr Pro  Gln Pro Pro Leu Asn  Ala Gln Met Leu Ala  Gln Arg Gln 
    1100                 1105                 1110             


Arg Glu  Leu Tyr Ser Gln Gln  His Arg Gln Arg Gln  Leu Ile Gln 
    1115                 1120                 1125             


Gln Gln  Arg Ala Met Leu Met  Arg Gln Gln Ser Phe  Gly Asn Asn 
    1130                 1135                 1140             


Leu Pro  Pro Ser Ser Gly Leu  Pro Val Gln Met Gly  Asn Pro Arg 
    1145                 1150                 1155             


Leu Pro  Gln Gly Ala Pro Gln  Gln Phe Pro Tyr Pro  Pro Asn Tyr 
    1160                 1165                 1170             


Gly Thr  Asn Pro Gly Thr Pro  Pro Ala Ser Thr Ser  Pro Phe Ser 
    1175                 1180                 1185             


Gln Leu  Ala Ala Asn Pro Glu  Ala Ser Leu Ala Asn  Arg Asn Ser 
    1190                 1195                 1200             


Met Val  Ser Arg Gly Met Thr  Gly Asn Ile Gly Gly  Gln Phe Gly 
    1205                 1210                 1215             


Thr Gly  Ile Asn Pro Gln Met  Gln Gln Asn Val Phe  Gln Tyr Pro 
    1220                 1225                 1230             


Gly Ala  Gly Met Val Pro Gln  Gly Glu Ala Asn Phe  Ala Pro Ser 
    1235                 1240                 1245             


Leu Ser  Pro Gly Ser Ser Met  Val Pro Met Pro Ile  Pro Pro Pro 
    1250                 1255                 1260             


Gln Ser  Ser Leu Leu Gln Gln  Thr Pro Pro Ala Ser  Gly Tyr Gln 
    1265                 1270                 1275             


Ser Pro  Asp Met Lys Ala Trp  Gln Gln Gly Ala Ile  Gly Asn Asn 
    1280                 1285                 1290             


Asn Val  Phe Ser Gln Ala Val  Gln Asn Gln Pro Thr  Pro Ala Gln 
    1295                 1300                 1305             


Pro Gly  Val Tyr Asn Asn Met  Ser Ile Thr Val Ser  Met Ala Gly 
    1310                 1315                 1320             


Gly Asn  Thr Asn Val Gln Asn  Met Asn Pro Met Met  Ala Gln Met 
    1325                 1330                 1335             


Gln Met  Ser Ser Leu Gln Met  Pro Gly Met Asn Thr  Val Cys Pro 
    1340                 1345                 1350             


Glu Gln  Ile Asn Asp Pro Ala  Leu Arg His Thr Gly  Leu Tyr Cys 
    1355                 1360                 1365             


Asn Gln  Leu Ser Ser Thr Asp  Leu Leu Lys Thr Glu  Ala Asp Gly 
    1370                 1375                 1380             


Thr Gln  Gln Val Gln Gln Val  Gln Val Phe Ala Asp  Val Gln Cys 
    1385                 1390                 1395             


Thr Val  Asn Leu Val Gly Gly  Asp Pro Tyr Leu Asn  Gln Pro Gly 
    1400                 1405                 1410             


Pro Leu  Gly Thr Gln Lys Pro  Thr Ser Gly Pro Gln  Thr Pro Gln 
    1415                 1420                 1425             


Ala Gln  Gln Lys Ser Leu Leu  Gln Gln Leu Leu Thr  Glu 
    1430                 1435                 1440     


<210>  811
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  811

Met Asn Thr Phe Gln Asp Gln Ser Gly Ser Ser Ser Asn Arg Glu Pro 
1               5                   10                  15      


Leu Leu Arg Cys Ser Asp Ala Arg Arg Asp Leu Glu Leu Ala Ile Gly 
            20                  25                  30          


Gly Val Leu Arg Ala Glu Gln Gln Ile Lys Asp Asn Leu Arg Glu Val 
        35                  40                  45              


Lys Ala Gln Ile His Ser Cys Ile Ser Arg His Leu Glu Cys Leu Arg 
    50                  55                  60                  


Ser Arg Glu Val Trp Leu Tyr Glu Gln Val Asp Leu Ile Tyr Gln Leu 
65                  70                  75                  80  


Lys Glu Glu Thr Leu Gln Gln Gln Ala Gln Gln Leu Tyr Ser Leu Leu 
                85                  90                  95      


Gly Gln Phe Asn Cys Leu Thr His Gln Leu Glu Cys Thr Gln Asn Lys 
            100                 105                 110         


Asp Leu Ala Asn Gln Val Ser Val Cys Leu Glu Arg Leu Gly Ser Leu 
        115                 120                 125             


Thr Leu Lys Pro Glu Asp Ser Thr Val Leu Leu Phe Glu Ala Asp Thr 
    130                 135                 140                 


Ile Thr Leu Arg Gln Thr Ile Thr Thr Phe Gly Ser Leu Lys Thr Ile 
145                 150                 155                 160 


Gln Ile Pro Glu His Leu Met Ala His Ala Ser Ser Ala Asn Ile Gly 
                165                 170                 175     


Pro Phe Leu Glu Lys Arg Gly Cys Ile Ser Met Pro Glu Gln Lys Ser 
            180                 185                 190         


Ala Ser Gly Ile Val Ala Val Pro Phe Ser Glu Trp Leu Leu Gly Ser 
        195                 200                 205             


Lys Pro Ala Ser Gly Tyr Gln Ala Pro Tyr Ile Pro Ser Thr Asp Pro 
    210                 215                 220                 


Gln Asp Trp Leu Thr Gln Lys Gln Thr Leu Glu Asn Ser Gln Thr Ser 
225                 230                 235                 240 


Ser Arg Ala Cys Asn Phe Phe Asn Asn Val Gly Gly Asn Leu Lys Gly 
                245                 250                 255     


Leu Glu Asn Trp Leu Leu Lys Ser Glu Lys Ser Ser Tyr Gln Lys Cys 
            260                 265                 270         


Asn Ser His Ser Thr Thr Ser Ser Phe Ser Ile Glu Met Glu Lys Val 
        275                 280                 285             


Gly Asp Gln Glu Leu Pro Asp Gln Asp Glu Met Asp Leu Ser Asp Trp 
    290                 295                 300                 


Leu Val Thr Pro Gln Glu Ser His Lys Leu Arg Lys Pro Glu Asn Gly 
305                 310                 315                 320 


Ser Arg Glu Thr Ser Glu Lys Phe Lys Leu Leu Phe Gln Ser Tyr Asn 
                325                 330                 335     


Val Asn Asp Trp Leu Val Lys Thr Asp Ser Cys Thr Asn Cys Gln Gly 
            340                 345                 350         


Asn Gln Pro Lys Gly Val Glu Ile Glu Asn Leu Gly Asn Leu Lys Cys 
        355                 360                 365             


Leu Asn Asp His Leu Glu Ala Lys Lys Pro Leu Ser Thr Pro Ser Met 
    370                 375                 380                 


Val Thr Glu Asp Trp Leu Val Gln Asn His Gln Asp Pro Cys Lys Val 
385                 390                 395                 400 


Glu Glu Val Cys Arg Ala Asn Glu Pro Cys Thr Ser Phe Ala Glu Cys 
                405                 410                 415     


Val Cys Asp Glu Asn Cys Glu Lys Glu Ala Leu Tyr Lys Trp Leu Leu 
            420                 425                 430         


Lys Lys Glu Gly Lys Asp Lys Asn Gly Met Pro Val Glu Pro Lys Pro 
        435                 440                 445             


Glu Pro Glu Lys His Lys Asp Ser Leu Asn Met Trp Leu Cys Pro Arg 
    450                 455                 460                 


Lys Glu Val Ile Glu Gln Thr Lys Ala Pro Lys Ala Met Thr Pro Ser 
465                 470                 475                 480 


Arg Ile Ala Asp Ser Phe Gln Val Ile Lys Asn Ser Pro Leu Ser Glu 
                485                 490                 495     


Trp Leu Ile Arg Pro Pro Tyr Lys Glu Gly Ser Pro Lys Glu Val Pro 
            500                 505                 510         


Gly Thr Glu Asp Arg Ala Gly Lys Gln Lys Phe Lys Ser Pro Met Asn 
        515                 520                 525             


Thr Ser Trp Cys Ser Phe Asn Thr Ala Asp Trp Val Leu Pro Gly Lys 
    530                 535                 540                 


Lys Met Gly Asn Leu Ser Gln Leu Ser Ser Gly Glu Asp Lys Trp Leu 
545                 550                 555                 560 


Leu Arg Lys Lys Ala Gln Glu Val Leu Leu Asn Ser Pro Leu Gln Glu 
                565                 570                 575     


Glu His Asn Phe Pro Pro Asp His Tyr Gly Leu Pro Ala Val Cys Asp 
            580                 585                 590         


Leu Phe Ala Cys Met Gln Leu Lys Val Asp Lys Glu Lys Trp Leu Tyr 
        595                 600                 605             


Arg Thr Pro Leu Gln Met 
    610                 


<210>  812
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  812

Met Glu Asp Ser Gly Lys Thr Phe Ser Ser Glu Glu Glu Glu Ala Asn 
1               5                   10                  15      


Tyr Trp Lys Asp Leu Ala Met Thr Tyr Lys Gln Arg Ala Glu Asn Thr 
            20                  25                  30          


Gln Glu Glu Leu Arg Glu Phe Gln Glu Gly Ser Arg Glu Tyr Glu Ala 
        35                  40                  45              


Glu Leu Glu Thr Gln Leu Gln Gln Ile Glu Thr Arg Asn Arg Asp Leu 
    50                  55                  60                  


Leu Ser Glu Asn Asn Arg Leu Arg Met Glu Leu Glu Thr Ile Lys Glu 
65                  70                  75                  80  


Lys Phe Glu Val Gln His Ser Glu Gly Tyr Arg Gln Ile Ser Ala Leu 
                85                  90                  95      


Glu Asp Asp Leu Ala Gln Thr Lys Ala Ile Lys Asp Gln Leu Gln Lys 
            100                 105                 110         


Tyr Ile Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala Lys 
        115                 120                 125             


Arg Ala Thr Ile Met Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn Gln 
    130                 135                 140                 


Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys Glu 
145                 150                 155                 160 


Asn Leu Leu Glu Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp Leu 
                165                 170                 175     


Arg Gln Glu Leu Ala Val Gln Gln Lys Gln Glu Lys Pro Arg Thr Pro 
            180                 185                 190         


Met Pro Ser Ser Val Glu Ala Glu Arg Thr Asp Thr Ala Val Gln Ala 
        195                 200                 205             


Thr Gly Ser Val Pro Ser Thr Pro Ile Ala His Arg Gly Pro Ser Ser 
    210                 215                 220                 


Ser Leu Asn Thr Pro Gly Ser Phe Arg Arg Gly Leu Asp Asp Ser Thr 
225                 230                 235                 240 


Gly Gly Thr Pro Leu Thr Pro Ala Ala Arg Ile Ser Ala Leu Asn Ile 
                245                 250                 255     


Val Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala 
            260                 265                 270         


Ser Cys Arg Asn Leu Val Tyr Asp Gln Ser Pro Asn Arg Thr Gly Gly 
        275                 280                 285             


Pro Ala Ser Gly Arg Ser Ser Lys Asn Arg Asp Gly Gly Glu Arg Arg 
    290                 295                 300                 


Pro Ser Ser Thr Ser Val Pro Leu Gly Asp Lys Gly Leu Asp Thr Ser 
305                 310                 315                 320 


Cys Arg Trp Leu Ser Lys Ser Thr Thr Arg Ser Ser Ser Ser Cys 
                325                 330                 335 


<210>  813
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  813

Met Asp Gly Glu Asp Ile Pro Asp Phe Ser Ser Leu Lys Glu Glu Thr 
1               5                   10                  15      


Ala Tyr Trp Lys Glu Leu Ser Leu Lys Tyr Lys Gln Ser Phe Gln Glu 
            20                  25                  30          


Ala Arg Asp Glu Leu Val Glu Phe Gln Glu Gly Ser Arg Glu Leu Glu 
        35                  40                  45              


Ala Glu Leu Glu Ala Gln Leu Val Gln Ala Glu Gln Arg Asn Arg Asp 
    50                  55                  60                  


Leu Gln Ala Asp Asn Gln Arg Leu Lys Tyr Glu Val Glu Ala Leu Lys 
65                  70                  75                  80  


Glu Lys Leu Glu His Gln Tyr Ala Gln Ser Tyr Lys Gln Val Ser Val 
                85                  90                  95      


Leu Glu Asp Asp Leu Ser Gln Thr Arg Ala Ile Lys Glu Gln Leu His 
            100                 105                 110         


Lys Tyr Val Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala 
        115                 120                 125             


Lys Arg Ala Thr Ile Val Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn 
    130                 135                 140                 


Gln Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Leu Leu Val Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp 
                165                 170                 175     


Leu Arg Gln Glu Leu Ala Val Arg Glu Arg Gln Gln Glu Val Thr Arg 
            180                 185                 190         


Lys Ser Ala Pro Ser Ser Pro Thr Leu Asp Cys Glu Lys Met Asp Ser 
        195                 200                 205             


Ala Val Gln Ala Ser Leu Ser Leu Pro Ala Thr Pro Val Gly Lys Gly 
    210                 215                 220                 


Thr Glu Asn Thr Phe Pro Ser Pro Lys Ala Ile Pro Asn Gly Phe Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Thr Pro Ser Ala Arg Ile Ser Ala Leu Asn Ile Val 
                245                 250                 255     


Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala Ala 
            260                 265                 270         


Cys Arg Asn Phe Ala Lys Asp Gln Ala Ser Arg Lys Ser Tyr Ile Ser 
        275                 280                 285             


Gly Asn Val Asn Cys Gly Val Leu Asn Gly Asn Gly Thr Lys Phe Ser 
    290                 295                 300                 


Arg Ser Gly His Thr Ser Phe Phe Asp Lys Gly Ala Val Asn Gly Phe 
305                 310                 315                 320 


Asp Pro Ala Pro Pro Pro Pro Gly Leu Gly Ser Ser Arg Pro Ser Ser 
                325                 330                 335     


Ala Pro Gly Met Leu Pro Leu Ser Val 
            340                 345 


<210>  814
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  814

Met Ala Leu Ala Leu Ala Ala Leu Ala Ala Val Glu Pro Ala Cys Gly 
1               5                   10                  15      


Ser Arg Tyr Gln Gln Leu Gln Asn Glu Glu Glu Ser Gly Glu Pro Glu 
            20                  25                  30          


Gln Ala Ala Gly Asp Ala Pro Pro Pro Tyr Ser Ser Ile Ser Ala Glu 
        35                  40                  45              


Ser Ala Ala Tyr Phe Asp Tyr Lys Asp Glu Ser Gly Phe Pro Lys Pro 
    50                  55                  60                  


Pro Ser Tyr Asn Val Ala Thr Thr Leu Pro Ser Tyr Asp Glu Ala Glu 
65                  70                  75                  80  


Arg Thr Lys Ala Glu Ala Thr Ile Pro Leu Val Pro Gly Arg Asp Glu 
                85                  90                  95      


Asp Phe Val Gly Arg Asp Asp Phe Asp Asp Ala Asp Gln Leu Arg Ile 
            100                 105                 110         


Gly Asn Asp Gly Ile Phe Met Leu Thr Phe Phe Met Ala Phe Leu Phe 
        115                 120                 125             


Asn Trp Ile Gly Phe Phe Leu Ser Phe Cys Leu Thr Thr Ser Ala Ala 
    130                 135                 140                 


Gly Arg Tyr Gly Ala Ile Ser Gly Phe Gly Leu Ser Leu Ile Lys Trp 
145                 150                 155                 160 


Ile Leu Ile Val Arg Phe Ser Thr Tyr Phe Pro Gly Tyr Phe Asp Gly 
                165                 170                 175     


Gln Tyr Trp Leu Trp Trp Val Phe Leu Val Leu Gly Phe Leu Leu Phe 
            180                 185                 190         


Leu Arg Gly Phe Ile Asn Tyr Ala Lys Val Arg Lys Met Pro Glu Thr 
        195                 200                 205             


Phe Ser Asn Leu Pro Arg Thr Arg Val Leu Phe Ile Tyr 
    210                 215                 220     


<210>  815
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  815

Met Glu Glu Ser Gly Tyr Glu Ser Val Leu Cys Val Lys Pro Asp Val 
1               5                   10                  15      


His Val Tyr Arg Ile Pro Pro Arg Ala Thr Asn Arg Gly Tyr Arg Ala 
            20                  25                  30          


Ala Glu Trp Gln Leu Asp Gln Pro Ser Trp Ser Gly Arg Leu Arg Ile 
        35                  40                  45              


Thr Ala Lys Gly Gln Met Ala Tyr Ile Lys Leu Glu Asp Arg Thr Ser 
    50                  55                  60                  


Gly Glu Leu Phe Ala Gln Ala Pro Val Asp Gln Phe Pro Gly Thr Ala 
65                  70                  75                  80  


Val Glu Ser Val Thr Asp Ser Ser Arg Tyr Phe Val Ile Arg Ile Glu 
                85                  90                  95      


Asp Gly Asn Gly Arg Arg Ala Phe Ile Gly Ile Gly Phe Gly Asp Arg 
            100                 105                 110         


Gly Asp Ala Phe Asp Phe Asn Val Ala Leu Gln Asp His Phe Lys Trp 
        115                 120                 125             


Val Lys Gln Gln Cys Glu Phe Ala Lys Gln Ala Gln Asn Pro Asp Gln 
    130                 135                 140                 


Gly Pro Lys Leu Asp Leu Gly Phe Lys Glu Gly Gln Thr Ile Lys Leu 
145                 150                 155                 160 


Asn Ile Ala Asn Met Lys Lys Lys Glu Gly Ala Ala Gly Asn Pro Arg 
                165                 170                 175     


Val Arg Pro Ala Ser Thr Gly Gly Leu Ser Leu Leu Pro Pro Pro Pro 
            180                 185                 190         


Gly Gly Lys Thr Ser Thr Leu Ile Pro Pro Pro Gly Glu Gln Leu Ala 
        195                 200                 205             


Val Gly Gly Ser Leu Val Gln Pro Ala Val Ala Pro Ser Ser Gly Gly 
    210                 215                 220                 


Ala Pro Val Pro Trp Pro Gln Pro Asn Pro Ala Thr Ala Asp Ile Trp 
225                 230                 235                 240 


Gly Asp Phe Thr Lys Ser Thr Gly Ser Thr Ser Ser Gln Thr Gln Pro 
                245                 250                 255     


Gly Thr Gly Trp Val Gln Phe 
            260             


<210>  816
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  816

Met Asp Glu Gln Ser Gln Gly Met Gln Gly Pro Pro Val Pro Gln Phe 
1               5                   10                  15      


Gln Pro Gln Lys Ala Leu Arg Pro Asp Met Gly Tyr Asn Thr Leu Ala 
            20                  25                  30          


Asn Phe Arg Ile Glu Lys Lys Ile Gly Arg Gly Gln Phe Ser Glu Val 
        35                  40                  45              


Tyr Arg Ala Ala Cys Leu Leu Asp Gly Val Pro Val Ala Leu Lys Lys 
    50                  55                  60                  


Val Gln Ile Phe Asp Leu Met Asp Ala Lys Ala Arg Ala Asp Cys Ile 
65                  70                  75                  80  


Lys Glu Ile Asp Leu Leu Lys Gln Leu Asn His Pro Asn Val Ile Lys 
                85                  90                  95      


Tyr Tyr Ala Ser Phe Ile Glu Asp Asn Glu Leu Asn Ile Val Leu Glu 
            100                 105                 110         


Leu Ala Asp Ala Gly Asp Leu Ser Arg Met Ile Lys His Phe Lys Lys 
        115                 120                 125             


Gln Lys Arg Leu Ile Pro Glu Arg Thr Val Trp Lys Tyr Phe Val Gln 
    130                 135                 140                 


Leu Cys Ser Ala Leu Glu His Met His Ser Arg Arg Val Met His Arg 
145                 150                 155                 160 


Asp Ile Lys Pro Ala Asn Val Phe Ile Thr Ala Thr Gly Val Val Lys 
                165                 170                 175     


Leu Gly Asp Leu Gly Leu Gly Arg Phe Phe Ser Ser Lys Thr Thr Ala 
            180                 185                 190         


Ala His Ser Leu Val Gly Thr Pro Tyr Tyr Met Ser Pro Glu Arg Ile 
        195                 200                 205             


His Glu Asn Gly Tyr Asn Phe Lys Ser Asp Ile Trp Ser Leu Gly Cys 
    210                 215                 220                 


Leu Leu Tyr Glu Met Ala Ala Leu Gln Ser Pro Phe Tyr Gly Asp Lys 
225                 230                 235                 240 


Met Asn Leu Tyr Ser Leu Cys Lys Lys Ile Glu Gln Cys Asp Tyr Pro 
                245                 250                 255     


Pro Leu Pro Ser Asp His Tyr Ser Glu Glu Leu Arg Gln Leu Val Asn 
            260                 265                 270         


Met Cys Ile Asn Pro Asp Pro Glu Lys Arg Pro Asp Val Thr Tyr Val 
        275                 280                 285             


Tyr Asp Val Ala Lys Arg Met His Ala Cys Thr Ala Ser Ser 
    290                 295                 300         


<210>  817
<211>  969
<212>  PRT
<213>  Homo sapiens

<400>  817

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 
        435                 440                 445             


Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 
    450                 455                 460                 


Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 
465                 470                 475                 480 


Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 
                485                 490                 495     


Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 
            500                 505                 510         


His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 
        515                 520                 525             


Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 
    530                 535                 540                 


Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 
545                 550                 555                 560 


Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 
                565                 570                 575     


Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 
            580                 585                 590         


Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 
        595                 600                 605             


Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 
    610                 615                 620                 


Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 
625                 630                 635                 640 


Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 
                645                 650                 655     


His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 
            660                 665                 670         


Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 
        675                 680                 685             


Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 
    690                 695                 700                 


Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 
705                 710                 715                 720 


Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 
                725                 730                 735     


Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 
            740                 745                 750         


Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 
        755                 760                 765             


Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 
    770                 775                 780                 


Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 
785                 790                 795                 800 


Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 
                805                 810                 815     


Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 
            820                 825                 830         


Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 
        835                 840                 845             


Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 
    850                 855                 860                 


Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 
865                 870                 875                 880 


Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 
                885                 890                 895     


Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 
            900                 905                 910         


Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 
        915                 920                 925             


Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 
    930                 935                 940                 


Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 
945                 950                 955                 960 


Gln Glu Gly Pro Leu Glu Gly Lys Ile 
                965                 


<210>  818
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  818

Met Glu Gln Tyr Thr Ala Asn Ser Asn Ser Ser Thr Glu Gln Ile Val 
1               5                   10                  15      


Val Gln Ala Gly Gln Ile Gln Gln Gln Gln Gln Gly Gly Val Thr Ala 
            20                  25                  30          


Val Gln Leu Gln Thr Glu Ala Gln Val Ala Ser Ala Ser Gly Gln Gln 
        35                  40                  45              


Val Gln Thr Leu Gln Val Val Gln Gly Gln Pro Leu Met Val Gln Val 
    50                  55                  60                  


Ser Gly Gly Gln Leu Ile Thr Ser Thr Gly Gln Pro Ile Met Val Gln 
65                  70                  75                  80  


Ala Val Pro Gly Gly Gln Gly Gln Thr Ile Met Gln Val Pro Val Ser 
                85                  90                  95      


Gly Thr Gln Gly Leu Gln Gln Ile Gln Leu Val Pro Pro Gly Gln Ile 
            100                 105                 110         


Gln Ile Gln Gly Gly Gln Ala Val Gln Val Gln Gly Gln Gln Gly Gln 
        115                 120                 125             


Thr Gln Gln Ile Ile Ile Gln Gln Pro Gln Thr Ala Val Thr Ala Gly 
    130                 135                 140                 


Gln Thr Gln Thr Gln Gln Gln Ile Ala Val Gln Gly Gln Gln Val Ala 
145                 150                 155                 160 


Gln Thr Ala Glu Gly Gln Thr Ile Val Tyr Gln Pro Val Asn Ala Asp 
                165                 170                 175     


Gly Thr Ile Leu Gln Gln Val Thr Val Pro Val Ser Gly Met Ile Thr 
            180                 185                 190         


Ile Pro Ala Ala Ser Leu Ala Gly Ala Gln Ile Val Gln Thr Gly Ala 
        195                 200                 205             


Asn Thr Asn Thr Thr Ser Ser Gly Gln Gly Thr Val Thr Val Thr Leu 
    210                 215                 220                 


Pro Val Ala Gly Asn Val Val Asn Ser Gly Gly Met Val Met Met Val 
225                 230                 235                 240 


Pro Gly Ala Gly Ser Val Pro Ala Ile Gln Arg Ile Pro Leu Pro Gly 
                245                 250                 255     


Ala Glu Met Leu Glu Glu Glu Pro Leu Tyr Val Asn Ala Lys Gln Tyr 
            260                 265                 270         


His Arg Ile Leu Lys Arg Arg Gln Ala Arg Ala Lys Leu Glu Ala Glu 
        275                 280                 285             


Gly Lys Ile Pro Lys Glu Arg Arg Lys Tyr Leu His Glu Ser Arg His 
    290                 295                 300                 


Arg His Ala Met Ala Arg Lys Arg Gly Glu Gly Gly Arg Phe Phe Ser 
305                 310                 315                 320 


Pro Lys Glu Lys Asp Ser Pro His Met Gln Asp Pro Asn Gln Ala Asp 
                325                 330                 335     


Glu Glu Ala Met Thr Gln Ile Ile Arg Val Ser 
            340                 345         


<210>  819
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  819

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  820
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  820

Met Gly Glu Glu Gly Gly Ser Ala Ser His Asp Glu Glu Glu Arg Ala 
1               5                   10                  15      


Ser Val Leu Leu Gly His Ser Pro Gly Cys Glu Met Cys Ser Gln Glu 
            20                  25                  30          


Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu Leu Leu Val Ser Gly 
        35                  40                  45              


Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp Leu Leu Ser Trp Glu 
    50                  55                  60                  


Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr Val Trp Asn Lys Gly 
                85                  90                  95      


Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala Gln Glu Ala Gln Ala 
            100                 105                 110         


Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp Asp Pro His Ser Leu 
        115                 120                 125             


His Pro Ala Arg Asp Leu Gln Ser His Arg Pro Ala Ile Val Arg Arg 
    130                 135                 140                 


Leu His Ser His Val Glu Asn Met Leu Asp Leu Ala Trp Glu Arg Gly 
145                 150                 155                 160 


Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg Leu Pro Ile Phe Thr 
                165                 170                 175     


Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val Gln Glu Leu Pro Val 
        195                 200                 205             


Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys Lys Lys Tyr Met Ala 
    210                 215                 220                 


Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg Phe Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile Tyr Thr Glu Asn Val 
                245                 250                 255     


Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly Pro Pro Gln Lys Ser 
            260                 265                 270         


Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser Thr Pro Gly His Leu 
        275                 280                 285             


Asn Asp Asp Ala Asp Thr Val Leu Val Val Gly Glu Ala Gly Ser Gly 
    290                 295                 300                 


Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu Trp Ala Ala Gly Gln 
305                 310                 315                 320 


Asp Phe Gln Glu Phe Leu Phe Val Phe Pro Phe Ser Cys Arg Gln Leu 
                325                 330                 335     


Gln Cys Met Ala Lys Pro Leu Ser Val Arg Thr Leu Leu Phe Glu His 
            340                 345                 350         


Cys Cys Trp Pro Asp Val Gly Gln Glu Asp Ile Phe Gln Leu Leu Leu 
        355                 360                 365             


Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp Gly Phe Asp Glu Phe 
    370                 375                 380                 


Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys Ser Pro Thr Asp Pro 
385                 390                 395                 400 


Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu Gln Gly Asn Leu Leu 
                405                 410                 415     


Lys Asn Ala Arg Lys Val Val Thr Ser Arg Pro Ala Ala Val Ser Ala 
            420                 425                 430         


Phe Leu Arg Lys Tyr Ile Arg Thr Glu Phe Asn Leu Lys Gly Phe Ser 
        435                 440                 445             


Glu Gln Gly Ile Glu Leu Tyr Leu Arg Lys Arg His His Glu Pro Gly 
    450                 455                 460                 


Val Ala Asp Arg Leu Ile Arg Leu Leu Gln Glu Thr Ser Ala Leu His 
465                 470                 475                 480 


Gly Leu Cys His Leu Pro Val Phe Ser Trp Met Val Ser Lys Cys His 
                485                 490                 495     


Gln Glu Leu Leu Leu Gln Glu Gly Gly Ser Pro Lys Thr Thr Thr Asp 
            500                 505                 510         


Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu His Ala Thr Pro Pro 
        515                 520                 525             


Asp Ser Ala Ser Gln Gly Leu Gly Pro Ser Leu Leu Arg Gly Arg Leu 
    530                 535                 540                 


Pro Thr Leu Leu His Leu Gly Arg Leu Ala Leu Trp Gly Leu Gly Met 
545                 550                 555                 560 


Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val Ser 
                565                 570                 575     


Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val Val 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln Cys 
        595                 600                 605             


Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro Ala 
    610                 615                 620                 


Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro Met 
625                 630                 635                 640 


Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys Asp 
                645                 650                 655     


Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu Gln 
            660                 665                 670         


Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp Gly 
        675                 680                 685             


Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg Gln 
    690                 695                 700                 


Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe His 
705                 710                 715                 720 


Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala Met 
                725                 730                 735     


Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu Glu 
            740                 745                 750         


Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu Lys 
        755                 760                 765             


Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala Phe 
    770                 775                 780                 


Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr Asn 
785                 790                 795                 800 


Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly Val 
                805                 810                 815     


Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly Ile 
            820                 825                 830         


Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys Leu 
        835                 840                 845             


Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met Ala 
    850                 855                 860                 


Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Leu Gly Asn 
865                 870                 875                 880 


Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu Gly Leu Arg 
                885                 890                 895     


Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn Arg Val Gly 
            900                 905                 910         


Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp His Gln Ser 
        915                 920                 925             


Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser Val Gly Ala 
    930                 935                 940                 


Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu Glu Glu Leu 
945                 950                 955                 960 


Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys Ser Leu Ala 
                965                 970                 975     


Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys Leu Ser Asn 
            980                 985                 990         


Asn Cys Ile Thr Tyr Leu Gly Ala  Glu Ala Leu Leu Gln  Ala Leu Glu 
        995                 1000                 1005             


Arg Asn  Asp Thr Ile Leu Glu  Val Trp Leu Arg Gly  Asn Thr Phe 
    1010                 1015                 1020             


Ser Leu  Glu Glu Val Asp Lys  Leu Gly Cys Arg Asp  Thr Arg Leu 
    1025                 1030                 1035             


Leu Leu  
    1040 


<210>  821
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  821

Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr 
1               5                   10                  15      


His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gln Asn 
            20                  25                  30          


Ile Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu 
        35                  40                  45              


Ser Leu Gln Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu 
    50                  55                  60                  


Tyr Glu Arg Glu Ala Ile Leu Glu Tyr Ile Leu His Gln Lys Lys Glu 
65                  70                  75                  80  


Ile Ala Arg Gln Met Lys Ala Tyr Glu Lys Gln Arg Gly Thr Arg Arg 
                85                  90                  95      


Glu Glu Gln Lys Glu Leu Gln Arg Ala Ala Ser Gln Asp His Val Arg 
            100                 105                 110         


Gly Phe Leu Glu Lys Glu Ser Ala Ile Val Ser Arg Pro Leu Asn Pro 
        115                 120                 125             


Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gln Pro 
    130                 135                 140                 


Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 
145                 150                 155                 160 


Ser Phe Trp Ile Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu 
                165                 170                 175     


Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu 
            180                 185                 190         


Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser 
        195                 200                 205             


Val Asp Arg Val Gly Leu Ile Thr Arg Ser Glu Arg Tyr Val Cys Ala 
    210                 215                 220                 


Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu Ile Arg 
                245                 250                 255     


Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp 
            260                 265                 270         


Ile Ile Val Leu Gln Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val 
        275                 280                 285             


Lys Leu Gln Ala Glu Lys Ser Arg Pro Val Met Gln Ala 
    290                 295                 300     


<210>  822
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  822

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  823
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  823

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         


<210>  824
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  824

Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg 
1               5                   10                  15      


Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser 
            20                  25                  30          


Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr 
        35                  40                  45              


Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His 
    50                  55                  60                  


Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg 
65                  70                  75                  80  


Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala 
                85                  90                  95      


His Leu Gln Thr Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln 
            100                 105                 110         


Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro 
        115                 120                 125             


Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu 
    130                 135                 140                 


Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala 
145                 150                 155                 160 


Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala 
                165                 170                 175     


Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu 
            180                 185                 190         


Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys 
        195                 200                 205             


Gly Pro Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr 
    210                 215                 220                 


Ser Glu Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser 
225                 230                 235                 240 


Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile 
                245                 250                 255     


Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro 
            260                 265                 270         


Leu Met Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
        275                 280                 285         


<210>  825
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  825

Met Leu Thr Gln Leu Lys Ala Lys Ser Glu Gly Lys Leu Ala Lys Gln 
1               5                   10                  15      


Ile Cys Lys Val Val Leu Asp His Phe Glu Lys Gln Tyr Ser Lys Glu 
            20                  25                  30          


Leu Gly Asp Ala Trp Asn Thr Val Arg Glu Ile Leu Thr Ser Pro Ser 
        35                  40                  45              


Cys Trp Gln Tyr Ala Val Leu Leu Asn Arg Phe Asn Tyr Pro Phe Glu 
    50                  55                  60                  


Leu Glu Lys Asp Leu His Leu Lys Gly Tyr His Thr Leu Ser Gln Gly 
65                  70                  75                  80  


Ser Leu Pro Asn Tyr Pro Lys Ser Val Lys Cys Tyr Leu Ser Arg Thr 
                85                  90                  95      


Pro Gly Arg Ile Pro Ser Glu Arg His Gln Ile Gly Asn Leu Lys Lys 
            100                 105                 110         


Tyr Tyr Leu Leu Asn Ala Ala Ser Leu Leu Pro Val Leu Ala Leu Glu 
        115                 120                 125             


Leu Arg Asp Gly Glu Lys Val Leu Asp Leu Cys Ala Ala Pro Gly Gly 
    130                 135                 140                 


Lys Ser Ile Ala Leu Leu Gln Cys Ala Cys Pro Gly Tyr Leu His Cys 
145                 150                 155                 160 


Asn Glu Tyr Asp Ser Leu Arg Leu Arg Trp Leu Arg Gln Thr Leu Glu 
                165                 170                 175     


Ser Phe Ile Pro Gln Pro Leu Ile Asn Val Ile Lys Val Ser Glu Leu 
            180                 185                 190         


Asp Gly Arg Lys Met Gly Asp Ala Gln Pro Glu Met Phe Asp Lys Val 
        195                 200                 205             


Leu Val Asp Ala Pro Cys Ser Asn Asp Arg Ser Trp Leu Phe Ser Ser 
    210                 215                 220                 


Asp Ser Gln Lys Ala Ser Cys Arg Ile Ser Gln Arg Arg Asn Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Ile Glu Leu Leu Arg Ser Ala Ile Lys Ala Leu Arg Pro 
                245                 250                 255     


Gly Gly Ile Leu Val Tyr Ser Thr Cys Thr Leu Ser Lys Ala Glu Asn 
            260                 265                 270         


Gln Asp Val Ile Ser Glu Ile Leu Asn Ser His Gly Asn Ile Met Pro 
        275                 280                 285             


Met Asp Ile Lys Gly Ile Ala Arg Thr Cys Ser His Asp Phe Thr Phe 
    290                 295                 300                 


Ala Pro Thr Gly Gln Glu Cys Gly Leu Leu Val Ile Pro Asp Lys Gly 
305                 310                 315                 320 


Lys Ala Trp Gly Pro Met Tyr Val Ala Lys Leu Lys Lys Ser Trp Ser 
                325                 330                 335     


Thr Gly Lys Trp 
            340 


<210>  826
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  826

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 


<210>  827
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  827

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Val Lys Val Ile 
        675                 680                 685         


<210>  828
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  828

Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp 
1               5                   10                  15      


Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu 
            20                  25                  30          


Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His 
        35                  40                  45              


Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val 
    50                  55                  60                  


Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg 
65                  70                  75                  80  


Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu 
                85                  90                  95      


Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met 
            100                 105                 110         


Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met 
        115                 120                 125             


Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly 
    130                 135                 140                 


Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu 
145                 150                 155                 160 


Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser 
                165                 170                 175     


Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser 
            180                 185                 190         


Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Tyr Val Lys Ala Arg 
    210                 215                 220                 


Ser Pro Arg Ala Asn Leu Pro Pro Leu Tyr Ala Leu Glu Leu Leu Thr 
225                 230                 235                 240 


Ile Tyr Ala Trp Glu Met Gly Thr Glu Glu Asp Glu Asn Phe Met Leu 
                245                 250                 255     


Asp Glu Gly Phe Thr Thr Val Met Asp Leu Leu Leu Glu Tyr Glu Val 
            260                 265                 270         


Ile Cys Ile Tyr Trp Thr Lys Tyr Tyr Thr Leu His Asn Ala Ile Ile 
        275                 280                 285             


Glu Asp Cys Val Arg Lys Gln Leu Lys Lys Glu Arg Pro Ile Ile Leu 
    290                 295                 300                 


Asp Pro Ala Asp Pro Thr Leu Asn Val Ala Glu Gly Tyr Arg Trp Asp 
305                 310                 315                 320 


Ile Val Ala Gln Arg Ala Ser Gln Cys Leu Lys Gln Asp Cys Cys Tyr 
                325                 330                 335     


Asp Asn Arg Glu Asn Pro Ile Ser Ser Trp Asn Val Lys Arg Ala Arg 
            340                 345                 350         


Asp Ile His Leu Thr Val Glu Gln Arg Gly Tyr Pro Asp Phe Asn Leu 
        355                 360                 365             


Ile Val Asn Pro Tyr Glu Pro Ile Arg Lys Val Lys Glu Lys Ile Arg 
    370                 375                 380                 


Arg Thr Arg Gly Tyr Ser Gly Leu Gln Arg Leu Ser Phe Gln Val Pro 
385                 390                 395                 400 


Gly Ser Glu Arg Gln Leu Leu Ser Ser Arg Cys Ser Leu Ala Lys Tyr 
                405                 410                 415     


Gly Ile Phe Ser His Thr His Ile Tyr Leu Leu Glu Thr Ile Pro Ser 
            420                 425                 430         


Glu Ile Gln Val Phe Val Lys Asn Pro Asp Gly Gly Ser Tyr Ala Tyr 
        435                 440                 445             


Ala Ile Asn Pro Asn Ser Phe Ile Leu Gly Leu Lys Gln Gln Ile Glu 
    450                 455                 460                 


Asp Gln Gln Gly Leu Pro Lys Lys Gln Gln Gln Leu Glu Phe Gln Gly 
465                 470                 475                 480 


Gln Val Leu Gln Asp Trp Leu Gly Leu Gly Ile Tyr Gly Ile Gln Asp 
                485                 490                 495     


Ser Asp Thr Leu Ile Leu Ser Lys Lys Lys Gly Glu Ala Leu Phe Pro 
            500                 505                 510         


Ala Ser 
        


<210>  829
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  829

Met Gly Asn Leu Leu Gly Gly Val Ser Phe Arg Glu Pro Thr Thr Val 
1               5                   10                  15      


Glu Asp Cys Asp Ser Thr Trp Gln Thr Asp Ser Glu Pro Glu Pro Glu 
            20                  25                  30          


Glu Pro Gly Pro Gly Gly Gly Ser Glu Gly Pro Gly Gln Glu Ser Glu 
        35                  40                  45              


Gln Pro Ala Gln Pro Pro Glu Gln Ala Gly Gly Arg Pro Gly Ala Ser 
    50                  55                  60                  


Pro Ala Pro Asp Glu Asp Ala Glu Ala Ala Gly Ala Glu Gln Gly Gly 
65                  70                  75                  80  


Asp Ser Thr Glu Ala Thr Ala Lys Pro Lys Arg Ser Phe Tyr Ala Ala 
                85                  90                  95      


Arg Asp Leu Tyr Lys Tyr Arg His Gln Tyr Pro Asn Phe Lys Asp Ile 
            100                 105                 110         


Arg Tyr Gln Asn Asp Leu Ser Asn Leu Arg Phe Tyr Lys Asn Lys Ile 
        115                 120                 125             


Pro Phe Lys Pro Asp Gly Val Tyr Ile Glu Glu Val Leu Ser Lys Trp 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Leu Glu His Asn His Thr Tyr Ile Gln Trp 
145                 150                 155                 160 


Leu Phe Pro Leu Arg Glu Gln Gly Leu Asn Phe Tyr Ala Lys Glu Leu 
                165                 170                 175     


Thr Thr Tyr Glu Ile Glu Glu Phe Lys Lys Thr Lys Glu Ala Ile Arg 
            180                 185                 190         


Arg Phe Leu Leu Ala Tyr Lys Met Met Leu Glu Phe Phe Gly Ile Lys 
        195                 200                 205             


Leu Thr Asp Lys Thr Gly Asn Val Ala Arg Ala Val Asn Trp Gln Glu 
    210                 215                 220                 


Arg Phe Gln His Leu Asn Glu Ser Gln His Asn Tyr Leu Arg Ile Thr 
225                 230                 235                 240 


Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Tyr Glu Ser Phe Lys Ser 
                245                 250                 255     


Pro Leu Val Lys Phe Ile Leu His Glu Ala Leu Val Glu Asn Thr Ile 
            260                 265                 270         


Pro Asn Ile Lys Gln Ser Ala Leu Glu Tyr Phe Val Tyr Thr Ile Arg 
        275                 280                 285             


Asp Arg Arg Glu Arg Arg Lys Leu Leu Arg Phe Ala Gln Lys His Tyr 
    290                 295                 300                 


Thr Pro Ser Glu Asn Phe Ile Trp Gly Pro Pro Arg Lys Glu Gln Ser 
305                 310                 315                 320 


Glu Gly Ser Lys Ala Gln Lys Met Ser Ser Pro Leu Ala Ser Ser His 
                325                 330                 335     


Asn Ser Gln Thr Ser Met His Lys Lys Ala Lys Asp Ser Lys Asn Ser 
            340                 345                 350         


Ser Ser Ala Val His Leu Asn Ser Lys Thr Ala Glu Asp Lys Lys Val 
        355                 360                 365             


Ala Pro Lys Glu Pro Val Glu Glu Thr Asp Arg Pro Ser Pro Glu Pro 
    370                 375                 380                 


Ser Asn Glu Ala Ala Lys Pro Arg Asn Thr Glu Lys Asp Ser Asn Ala 
385                 390                 395                 400 


Glu Asn Met Asn Ser Gln Pro Glu Lys Thr Val Thr Thr Pro Thr Glu 
                405                 410                 415     


Lys Lys Glu Ser Val Ser Pro Glu Asn Asn Glu Glu Gly Gly Asn Asp 
            420                 425                 430         


Asn Gln Asp Asn Glu Asn Pro Gly Asn Thr Asn Cys His Asp Val Val 
        435                 440                 445             


Leu Val Gln 
    450     


<210>  830
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Gln Gly Gly Glu Pro Val Ser Thr Met Lys Val Ser Glu Ser Glu 
1               5                   10                  15      


Gly Lys Leu Glu Gly Gln Ala Thr Ala Val Thr Pro Asn Lys Asn Ser 
            20                  25                  30          


Ser Cys Gly Gly Gly Ile Ser Ser Ser Ser Ser Ser Arg Gly Gly Ser 
        35                  40                  45              


Ala Lys Gly Trp Gln Tyr Ser Asp His Met Glu Asn Val Tyr Gly Tyr 
    50                  55                  60                  


Leu Met Lys Tyr Thr Asn Leu Val Thr Gly Trp Gln Tyr Arg Phe Phe 
65                  70                  75                  80  


Val Leu Asn Asn Glu Ala Gly Leu Leu Glu Tyr Phe Val Asn Glu Gln 
                85                  90                  95      


Ser Arg Asn Gln Lys Pro Arg Gly Thr Leu Gln Leu Ala Gly Ala Val 
            100                 105                 110         


Ile Ser Pro Ser Asp Glu Asp Ser His Thr Phe Thr Val Asn Ala Ala 
        115                 120                 125             


Ser Gly Glu Gln Tyr Lys Leu Arg Ala Thr Asp Ala Lys Glu Arg Gln 
    130                 135                 140                 


His Trp Val Ser Arg Leu Gln Ile Cys Thr Gln His His Thr Glu Ala 
145                 150                 155                 160 


Ile Gly Lys Asn Asn Pro Pro Leu Lys Ser Arg Ser Phe Ser Leu Ala 
                165                 170                 175     


Ser Ser Ser Asn Ser Pro Ile Ser Gln Arg Arg Pro Ser Gln Asn Ala 
            180                 185                 190         


Ile Ser Phe Phe Asn Val Gly His Ser Lys Leu Gln Ser Leu Ser Lys 
        195                 200                 205             


Arg Thr Asn Leu Pro Pro Asp His Leu Val Glu Val Arg Glu Met Met 
    210                 215                 220                 


Ser His Ala Glu Gly Gln Gln Arg Asp Leu Ile Arg Arg Ile Glu Cys 
225                 230                 235                 240 


Leu Pro Thr Ser Gly His Leu Ser Ser Leu Asp Gln Asp Leu Leu Met 
                245                 250                 255     


Leu Lys Ala Thr Ser Met Ala Thr Met Asn Cys Leu Asn Asp Cys Phe 
            260                 265                 270         


His Ile Leu Gln Leu Gln His Ala Ser His Gln Lys Gly Ser Leu Pro 
        275                 280                 285             


Ser Gly Thr Thr Ile Glu Trp Leu Glu Pro Lys Ile Ser Leu Ser Asn 
    290                 295                 300                 


His Tyr Lys Asn Gly Ala Asp Gln Pro Phe Ala Thr Asp Gln Ser Lys 
305                 310                 315                 320 


Pro Val Ala Val Pro Glu Glu Gln Pro Val Ala Glu Ser Gly Leu Leu 
                325                 330                 335     


Ala Arg Glu Pro Glu Glu Ile Asn Ala Asp Asp Glu Ile Glu Asp Thr 
            340                 345                 350         


Cys Asp His Lys Glu Asp Asp Leu Gly Ala Val Glu Glu Gln Arg Ser 
        355                 360                 365             


Val Ile Leu His Leu Leu Ser Gln Leu Lys Leu Gly Met Asp Leu Thr 
    370                 375                 380                 


Arg Val Val Leu Pro Thr Phe Ile Leu Glu Lys Arg Ser Leu Leu Glu 
385                 390                 395                 400 


Met Tyr Ala Asp Phe Met Ser His Pro Asp Leu Phe Ile Ala Ile Thr 
                405                 410                 415     


Asn Gly Ala Thr Ala Glu Asp Arg Met Ile Arg Phe Val Glu Tyr Tyr 
            420                 425                 430         


Leu Thr Ser Phe His Glu Gly Arg Lys Gly Ala Ile Ala Lys Lys Pro 
        435                 440                 445             


Tyr Asn Pro Ile Ile Gly Glu Thr Phe His Cys Ser Trp Lys Met Pro 
    450                 455                 460                 


Lys Ser Glu Val Ala Ser Ser Val Phe Ser Ser Ser Ser Thr Gln Gly 
465                 470                 475                 480 


Val Thr Asn His Ala Pro Leu Ser Gly Glu Ser Leu Thr Gln Val Gly 
                485                 490                 495     


Ser Asp Cys Tyr Thr Val Arg Phe Val Ala Glu Gln Val Ser His His 
            500                 505                 510         


Pro Pro Val Ser Gly Phe Tyr Ala Glu Cys Thr Glu Arg Lys Met Cys 
        515                 520                 525             


Val Asn Ala His Val Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile 
    530                 535                 540                 


Gly Val Thr Met Val Gly Glu Gly Ile Leu Ser Leu Leu Glu His Gly 
545                 550                 555                 560 


Glu Glu Tyr Thr Phe Ser Leu Pro Cys Ala Tyr Ala Arg Ser Ile Leu 
                565                 570                 575     


Thr Val Pro Trp Val Glu Leu Gly Gly Lys Val Ser Val Asn Cys Ala 
            580                 585                 590         


Lys Thr Gly Tyr Ser Ala Ser Ile Thr Phe His Thr Lys Pro Phe Tyr 
        595                 600                 605             


Gly Gly Lys Leu His Arg Val Thr Ala Glu Val Lys His Asn Ile Thr 
    610                 615                 620                 


Asn Thr Val Val Cys Arg Val Gln Gly Glu Trp Asn Ser Val Leu Glu 
625                 630                 635                 640 


Phe Thr Tyr Ser Asn Gly Glu Thr Lys Tyr Val Asp Leu Thr Lys Leu 
                645                 650                 655     


Ala Val Thr Lys Lys Arg Val Arg Pro Leu Glu Lys Gln Asp Pro Phe 
            660                 665                 670         


Glu Ser Arg Arg Leu Trp Lys Asn Val Thr Asp Ser Leu Arg Glu Ser 
        675                 680                 685             


Glu Ile Asp Lys Ala Thr Glu His Lys His Thr Leu Glu Glu Arg Gln 
    690                 695                 700                 


Arg Thr Glu Glu Arg His Arg Thr Glu Thr Gly Thr Pro Trp Lys Thr 
705                 710                 715                 720 


Lys Tyr Phe Ile Lys Glu Gly Asp Gly Trp Val Tyr His Lys Pro Leu 
                725                 730                 735     


Trp Lys Ile Ile Pro Thr Thr Gln Pro Ala Glu 
            740                 745         


<210>  831
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  831

Met Asn Gly Glu Glu Glu Phe Phe Asp Ala Val Thr Glu Ala Asn Gln 
1               5                   10                  15      


Lys Val Thr Gly Met Ile Asp Leu Asp Thr Ser Lys Asn Asn Arg Ile 
            20                  25                  30          


Gly Lys Thr Gly Glu Arg Pro Ser Gln Glu Asn Gly Ile Gln Lys His 
        35                  40                  45              


Arg Thr Ser Leu Pro Ala Pro Met Phe Ser Arg Ser Asp Phe Ser Val 
    50                  55                  60                  


Trp Thr Ile Leu Lys Lys Cys Val Gly Leu Glu Leu Ser Lys Ile Thr 
65                  70                  75                  80  


Met Pro Ile Ala Phe Asn Glu Pro Leu Ser Phe Leu Gln Arg Ile Thr 
                85                  90                  95      


Glu Tyr Met Glu His Val Tyr Leu Ile His Arg Ala Ser Cys Gln Pro 
            100                 105                 110         


Gln Pro Leu Glu Arg Met Gln Ser Val Ala Ala Phe Ala Val Ser Ala 
        115                 120                 125             


Val Ala Ser Gln Trp Glu Arg Thr Gly Lys Pro Phe Asn Pro Leu Leu 
    130                 135                 140                 


Gly Glu Thr Tyr Glu Leu Ile Arg Glu Asp Leu Gly Phe Arg Phe Ile 
145                 150                 155                 160 


Ser Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe His Ser Glu 
                165                 170                 175     


Gly Leu Asn His Asp Phe Leu Phe His Gly Ser Ile Tyr Pro Lys Leu 
            180                 185                 190         


Lys Phe Trp Gly Lys Ser Val Glu Ala Glu Pro Arg Gly Thr Ile Thr 
        195                 200                 205             


Leu Glu Leu Leu Lys His Asn Glu Ala Tyr Thr Trp Thr Asn Pro Thr 
    210                 215                 220                 


Cys Cys Val His Asn Val Ile Ile Gly Lys Leu Trp Ile Glu Gln Tyr 
225                 230                 235                 240 


Gly Thr Val Glu Ile Leu Asn His Arg Thr Gly His Lys Cys Val Leu 
                245                 250                 255     


His Phe Lys Pro Cys Gly Leu Phe Gly Lys Glu Leu His Lys Val Glu 
            260                 265                 270         


Gly His Ile Gln Asp Lys Asn Lys Lys Lys Leu Phe Met Ile Tyr Gly 
        275                 280                 285             


Lys Trp Thr Glu Cys Leu Trp Gly Ile Asp Pro Val Ser Tyr Glu Ser 
    290                 295                 300                 


Phe Lys Lys Gln Glu Arg Arg Gly Asp His Leu Arg Lys Ala Lys Leu 
305                 310                 315                 320 


Asp Glu Asp Ser Gly Lys Ala Asp Ser Asp Val Ala Asp Asp Val Pro 
                325                 330                 335     


Val Ala Gln Glu Thr Val Gln Val Ile Pro Gly Ser Lys Leu Leu Trp 
            340                 345                 350         


Arg Ile Asn Thr Arg Pro Pro Asn Ser Ala Gln Met Tyr Asn Phe Thr 
        355                 360                 365             


Ser Phe Thr Val Ser Leu Asn Glu Leu Glu Thr Gly Met Glu Lys Thr 
    370                 375                 380                 


Leu Pro Pro Thr Asp Cys Arg Leu Arg Pro Asp Ile Arg Gly Met Glu 
385                 390                 395                 400 


Asn Gly Asn Met Asp Leu Ala Ser Gln Glu Lys Glu Arg Leu Glu Glu 
                405                 410                 415     


Lys Gln Arg Glu Ala Arg Arg Glu Arg Ala Lys Glu Glu Ala Glu Trp 
            420                 425                 430         


Gln Thr Arg Trp Phe Tyr Pro Gly Asn Asn Pro Tyr Thr Gly Thr Pro 
        435                 440                 445             


Asp Trp Leu Tyr Ala Gly Asp Tyr Phe Glu Arg Asn Phe Ser Asp Cys 
    450                 455                 460                 


Pro Asp Ile Tyr 
465             


<210>  832
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  832

Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Leu Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asp 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Asn Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Val Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Ser 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala 
            340                 345                 350         


Gln Ser Ala Gln Ser Gln Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp 
        355                 360                 365             


Asp Thr Gly Ser Thr Val Ser Glu Lys Asp Asp Thr Lys Ala Lys Asn 
    370                 375                 380                 


Val Ser Ser Tyr Glu Lys Thr Gln Ser Tyr Pro Thr Asp Trp Ser Asp 
385                 390                 395                 400 


Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser 
                405                 410                 415     


Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg 
            420                 425                 430         


Ala Leu Tyr Asp Tyr Glu Gly Gln Glu His Asp Glu Leu Ser Phe Lys 
        435                 440                 445             


Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gln Gly Trp 
    450                 455                 460                 


Cys Lys Gly Arg Leu Asp Asn Gly Gln Val Gly Leu Tyr Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Glu Ala Ile Gln 
                485     


<210>  833
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  833

Met Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala 
1               5                   10                  15      


Asp Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys 
            20                  25                  30          


Lys Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala 
        35                  40                  45              


Gly Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys 
    50                  55                  60                  


Val Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr 
65                  70                  75                  80  


Ser Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro 
                85                  90                  95      


Arg Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr 
            100                 105                 110         


Arg Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu 
        115                 120                 125             


Asp Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg 
    130                 135                 140                 


Thr Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His 
145                 150                 155                 160 


Ser Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu 
                165                 170                 175     


Trp Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp 
            180                 185                 190         


His Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val 
        195                 200                 205             


Ser Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly 
    210                 215                 220                 


Tyr Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val 
225                 230                 235                 240 


Arg Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln 
                245                 250                 255     


Thr Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu 
            260                 265                 270         


Arg Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser 
        275                 280                 285             


Ser Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser 
    290                 295                 300                 


Gly Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile 
305                 310                 315                 320 


Lys Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly 
                325                 330                 335     


His Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe 
            340                 345                 350         


Ile Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys 
        355                 360                 365             


Asn Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr 
    370                 375                 380                 


Ser Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val 
385                 390                 395                 400 


Asp Gln Thr Val Lys Val Trp Glu Cys Arg 
                405                 410 


<210>  834
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Ala Gln Ala Gly Val Val Gly Glu Val Thr Gln Val Leu Cys Ala 
1               5                   10                  15      


Ala Gly Gly Ala Leu Glu Leu Pro Glu Leu Arg Arg Arg Leu Arg Met 
            20                  25                  30          


Gly Leu Ser Ala Asp Ala Leu Glu Arg Leu Leu Arg Gln Arg Gly Arg 
        35                  40                  45              


Phe Val Val Ala Val Arg Ala Gly Gly Ala Ala Ala Ala Pro Glu Arg 
    50                  55                  60                  


Val Val Leu Ala Ala Ser Pro Leu Arg Leu Cys Arg Ala His Gln Gly 
65                  70                  75                  80  


Ser Lys Pro Gly Cys Val Gly Leu Cys Ala Gln Leu His Leu Cys Arg 
                85                  90                  95      


Phe Met Val Tyr Gly Ala Cys Lys Phe Leu Arg Ala Gly Lys Asn Cys 
            100                 105                 110         


Arg Asn Ser His Ser Leu Thr Thr Glu His Asn Leu Ser Val Leu Arg 
        115                 120                 125             


Thr His Gly Val Asp His Leu Ser Tyr Asn Glu Leu Cys Gln Leu Leu 
    130                 135                 140                 


Phe Gln Asn Asp Pro Trp Leu Leu Pro Glu Ile Cys Gln His Tyr Asn 
145                 150                 155                 160 


Lys Gly Asp Gly Pro His Gly Ser Cys Ala Phe Gln Lys Gln Cys Ile 
                165                 170                 175     


Lys Leu His Ile Cys Gln Tyr Phe Leu Gln Gly Glu Cys Lys Phe Gly 
            180                 185                 190         


Thr Ser Cys Lys Arg Ser His Asp Phe Ser Asn Ser Glu Asn Leu Glu 
        195                 200                 205             


Lys Leu Glu Lys Leu Gly Met Ser Ser Asp Leu Val Ser Arg Leu Pro 
    210                 215                 220                 


Thr Ile Tyr Arg Asn Ala His Asp Ile Lys Asn Lys Ser Ser Ala Pro 
225                 230                 235                 240 


Ser Arg Val Pro Pro Leu Phe Val Pro Gln Gly Thr Ser Glu Arg Lys 
                245                 250                 255     


Asp Ser Ser Gly Ser Val Ser Pro Asn Thr Leu Ser Gln Glu Glu Gly 
            260                 265                 270         


Asp Gln Ile Cys Leu Tyr His Ile Arg Lys Ser Cys Ser Phe Gln Asp 
        275                 280                 285             


Lys Cys His Arg Val His Phe His Leu Pro Tyr Arg Trp Gln Phe Leu 
    290                 295                 300                 


Asp Arg Gly Lys Trp Glu Asp Leu Asp Asn Met Glu Leu Ile Glu Glu 
305                 310                 315                 320 


Ala Tyr Cys Asn Pro Lys Ile Glu Arg Ile Leu Cys Ser Glu Ser Ala 
                325                 330                 335     


Ser Thr Phe His Ser His Cys Leu Asn Phe Asn Ala Met Thr Tyr Gly 
            340                 345                 350         


Ala Thr Gln Ala Arg Arg Leu Ser Thr Ala Ser Ser Val Thr Lys Pro 
        355                 360                 365             


Pro His Phe Ile Leu Thr Thr Asp Trp Ile Trp Tyr Trp Ser Asp Glu 
    370                 375                 380                 


Phe Gly Ser Trp Gln Glu Tyr Gly Arg Gln Gly Thr Val His Pro Val 
385                 390                 395                 400 


Thr Thr Val Ser Ser Ser Asp Val Glu Lys Ala Tyr Leu Ala Tyr Cys 
                405                 410                 415     


Thr Pro Gly Ser Asp Gly Gln Ala Ala Thr Leu Lys Phe Gln Ala Gly 
            420                 425                 430         


Lys His Asn Tyr Glu Leu Asp Phe Lys Ala Phe Val Gln Lys Asn Leu 
        435                 440                 445             


Val Tyr Gly Thr Thr Lys Lys Val Cys Arg Arg Pro Lys Tyr Val Ser 
    450                 455                 460                 


Pro Gln Asp Val Thr Thr Met Gln Thr Cys Asn Thr Lys Phe Pro Gly 
465                 470                 475                 480 


Pro Lys Ser Ile Pro Asp Tyr Trp Asp Ser Ser Ala Leu Pro Asp Pro 
                485                 490                 495     


Gly Phe Gln Lys Ile Thr Leu Ser Ser Ser Ser Glu Glu Tyr Gln Lys 
            500                 505                 510         


Val Trp Asn Leu Phe Asn Arg Thr Leu Pro Phe Tyr Phe Val Gln Lys 
        515                 520                 525             


Ile Glu Arg Val Gln Asn Leu Ala Leu Trp Glu Val Tyr Gln Trp Gln 
    530                 535                 540                 


Lys Gly Gln Met Gln Lys Gln Asn Gly Gly Lys Ala Val Asp Glu Arg 
545                 550                 555                 560 


Gln Leu Phe His Gly Thr Ser Ala Ile Phe Val Asp Ala Ile Cys Gln 
                565                 570                 575     


Gln Asn Phe Asp Trp Arg Val Cys Gly Val His Gly Thr Ser Tyr Gly 
            580                 585                 590         


Lys Gly Ser Tyr Phe Ala Arg Asp Ala Ala Tyr Ser His His Tyr Ser 
        595                 600                 605             


Lys Ser Asp Thr Gln Thr His Thr Met Phe Leu Ala Arg Val Leu Val 
    610                 615                 620                 


Gly Glu Phe Val Arg Gly Asn Ala Ser Phe Val Arg Pro Pro Ala Lys 
625                 630                 635                 640 


Glu Gly Trp Ser Asn Ala Phe Tyr Asp Ser Cys Val Asn Ser Val Ser 
                645                 650                 655     


Asp Pro Ser Ile Phe Val Ile Phe Glu Lys His Gln Val Tyr Pro Glu 
            660                 665                 670         


Tyr Val Ile Gln Tyr Thr Thr Ser Ser Lys Pro Ser Val Thr Pro Ser 
        675                 680                 685             


Ile Leu Leu Ala Leu Gly Ser Leu Phe Ser Ser Arg Gln 
    690                 695                 700     


<210>  835
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  835

Met Asp Asp Gln Ser Arg Met Leu Gln Thr Leu Ala Gly Val Asn Leu 
1               5                   10                  15      


Ala Gly His Ser Val Gln Gly Gly Met Ala Leu Pro Pro Pro Pro His 
            20                  25                  30          


Gly His Glu Gly Ala Asp Gly Asp Gly Arg Lys Gln Asp Ile Gly Asp 
        35                  40                  45              


Ile Leu His Gln Ile Met Thr Ile Thr Asp Gln Ser Leu Asp Glu Ala 
    50                  55                  60                  


Gln Ala Lys Lys His Ala Leu Asn Cys His Arg Met Lys Pro Ala Leu 
65                  70                  75                  80  


Phe Ser Val Leu Cys Glu Ile Lys Glu Lys Thr Gly Leu Ser Ile Arg 
                85                  90                  95      


Gly Ala Gln Glu Glu Asp Pro Pro Asp Pro Gln Leu Met Arg Leu Asp 
            100                 105                 110         


Asn Met Leu Leu Ala Glu Gly Val Ser Gly Pro Glu Lys Gly Gly Gly 
        115                 120                 125             


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly Ser Ser Asp 
    130                 135                 140                 


Asn Ser Ile Glu His Ser Asp Tyr Arg Ala Lys Leu Thr Gln Ile Arg 
145                 150                 155                 160 


Gln Ile Tyr His Thr Glu Leu Glu Lys Tyr Glu Gln Ala Cys Asn Glu 
                165                 170                 175     


Phe Thr Thr His Val Met Asn Leu Leu Arg Glu Gln Ser Arg Thr Arg 
            180                 185                 190         


Pro Ile Ser Pro Lys Glu Ile Glu Arg Met Val Gly Ile Ile His Arg 
        195                 200                 205             


Lys Phe Ser Ser Ile Gln Met Gln Leu Lys Gln Ser Thr Cys Glu Ala 
    210                 215                 220                 


Val Met Ile Leu Arg Ser Arg Phe Leu Asp Ala Arg Arg Lys Arg Arg 
225                 230                 235                 240 


Asn Phe Ser Lys Gln Ala Thr Glu Ile Leu Asn Glu Tyr Phe Tyr Ser 
                245                 250                 255     


His Leu Ser Asn Pro Tyr Pro Ser Glu Glu Ala Lys Glu Glu Leu Ala 
            260                 265                 270         


Lys Lys Cys Ser Ile Thr Val Ser Gln Val Ser Asn Trp Phe Gly Asn 
        275                 280                 285             


Lys Arg Ile Arg Tyr Lys Lys Asn Ile Gly Lys Phe Gln Glu Glu Ala 
    290                 295                 300                 


Asn Leu Tyr Ala Ala Lys Thr Ala Val Thr Ala Ala His Ala Val Ala 
305                 310                 315                 320 


Ala Ala Val Gln Asn Asn Gln Thr Asn Ser Pro Thr Thr Pro Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Ser Phe Asn Leu Pro Asn Ser Gly Asp Met Phe Met 
            340                 345                 350         


Asn Met Gln Ser Leu Asn Gly Asp Ser Tyr Gln Gly Ser Gln Val Gly 
        355                 360                 365             


Ala Asn Val Gln Ser Gln Val Asp Thr Leu Arg His Val Ile Asn Gln 
    370                 375                 380                 


Thr Gly Gly Tyr Ser Asp Gly Leu Gly Gly Asn Ser Leu Tyr Ser Pro 
385                 390                 395                 400 


His Asn Leu Asn Ala Asn Gly Gly Trp Gln Asp Ala Thr Thr Pro Ser 
                405                 410                 415     


Ser Val Thr Ser Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr 
            420                 425                 430         


Ser Asn 
        


<210>  836
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  836

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser 
        195                 200                 205             


Phe Pro His Thr Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly 
    210                 215                 220                 


Pro Pro Leu Glu Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln 
225                 230                 235                 240 


Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe 
                245                 250                 255     


Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser 
            260                 265                 270         


Pro Glu Val Lys Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln Thr 
        275                 280                 285             


Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile 
    290                 295                 300                 


Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala 
305                 310                 315                 320 


Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val 
                325                 330                 335     


Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile 
            340                 345                 350         


Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360                 365     


<210>  837
<211>  1555
<212>  PRT
<213>  Homo sapiens

<400>  837

Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly Ala Arg Glu 
1               5                   10                  15      


Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu Thr Phe Asn 
            20                  25                  30          


Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu Glu Asn Leu 
        35                  40                  45              


Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln Thr Ala Lys 
    50                  55                  60                  


Ala Pro Ser Ser Glu Lys Leu Pro Val Met Tyr Leu Met Asp Ser Ile 
65                  70                  75                  80  


Val Lys Asn Val Gly Arg Glu Tyr Leu Thr Ala Phe Thr Lys Asn Leu 
                85                  90                  95      


Val Ala Thr Phe Ile Cys Val Phe Glu Lys Val Asp Glu Asn Thr Arg 
            100                 105                 110         


Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp Asp Glu Ile Phe Pro Leu 
        115                 120                 125             


Lys Lys Leu Tyr Ala Leu Asp Val Arg Val Asn Ser Leu Asp Pro Ala 
    130                 135                 140                 


Trp Pro Ile Lys Pro Leu Pro Pro Asn Val Asn Thr Ser Ser Ile His 
145                 150                 155                 160 


Val Asn Pro Lys Phe Leu Asn Lys Ser Pro Glu Glu Pro Ser Thr Pro 
                165                 170                 175     


Gly Thr Val Val Ser Ser Pro Ser Ile Ser Thr Pro Pro Ile Val Pro 
            180                 185                 190         


Asp Ile Gln Lys Asn Leu Thr Gln Glu Gln Leu Ile Arg Gln Gln Leu 
        195                 200                 205             


Leu Ala Lys Gln Lys Gln Leu Leu Glu Leu Gln Gln Lys Lys Leu Glu 
    210                 215                 220                 


Leu Glu Leu Glu Gln Ala Lys Ala Gln Leu Ala Val Ser Leu Ser Val 
225                 230                 235                 240 


Gln Gln Glu Thr Ser Asn Leu Gly Pro Gly Ser Ala Pro Ser Lys Leu 
                245                 250                 255     


His Val Ser Gln Ile Pro Pro Met Ala Val Lys Ala Pro His Gln Val 
            260                 265                 270         


Pro Val Gln Ser Glu Lys Ser Arg Pro Gly Pro Ser Leu Gln Ile Gln 
        275                 280                 285             


Asp Leu Lys Gly Thr Asn Arg Asp Pro Arg Leu Asn Arg Ile Ser Gln 
    290                 295                 300                 


His Ser His Gly Lys Asp Gln Ser His Arg Lys Glu Phe Leu Met Asn 
305                 310                 315                 320 


Thr Leu Asn Gln Ser Asp Thr Lys Thr Ser Lys Thr Ile Pro Ser Glu 
                325                 330                 335     


Lys Leu Asn Ser Ser Lys Gln Glu Lys Ser Lys Ser Gly Glu Lys Ile 
            340                 345                 350         


Thr Lys Lys Glu Leu Asp Gln Leu Asp Ser Lys Ser Lys Ser Lys Ser 
        355                 360                 365             


Lys Ser Pro Ser Pro Leu Lys Asn Lys Leu Ser His Thr Lys Asp Leu 
    370                 375                 380                 


Lys Asn Gln Glu Ser Glu Ser Met Arg Leu Ser Asp Met Asn Lys Arg 
385                 390                 395                 400 


Asp Pro Arg Leu Lys Lys His Leu Gln Asp Lys Thr Asp Gly Lys Asp 
                405                 410                 415     


Asp Asp Val Lys Glu Lys Arg Lys Thr Ala Glu Lys Lys Asp Lys Asp 
            420                 425                 430         


Glu His Met Lys Ser Ser Glu His Arg Leu Ala Gly Ser Arg Asn Lys 
        435                 440                 445             


Ile Ile Asn Gly Ile Val Gln Lys Gln Asp Thr Ile Thr Glu Glu Ser 
    450                 455                 460                 


Glu Lys Gln Gly Thr Lys Pro Gly Arg Ser Ser Thr Arg Lys Arg Ser 
465                 470                 475                 480 


Arg Ser Arg Ser Pro Lys Ser Arg Ser Pro Ile Ile His Ser Pro Lys 
                485                 490                 495     


Arg Arg Asp Arg Arg Ser Pro Lys Arg Arg Gln Arg Ser Met Ser Pro 
            500                 505                 510         


Thr Ser Thr Pro Lys Ala Gly Lys Ile Arg Gln Ser Gly Ala Lys Gln 
        515                 520                 525             


Ser His Met Glu Glu Phe Thr Pro Pro Ser Arg Glu Asp Arg Asn Ala 
    530                 535                 540                 


Lys Arg Ser Thr Lys Gln Asp Ile Arg Asp Pro Arg Arg Met Lys Lys 
545                 550                 555                 560 


Thr Glu Glu Glu Arg Pro Gln Glu Thr Thr Asn Gln His Ser Thr Lys 
                565                 570                 575     


Ser Gly Thr Glu Pro Lys Glu Asn Val Glu Asn Trp Gln Ser Ser Lys 
            580                 585                 590         


Ser Ala Lys Arg Trp Lys Ser Gly Trp Glu Glu Asn Lys Ser Leu Gln 
        595                 600                 605             


Gln Val Asp Glu His Ser Lys Pro Pro His Leu Arg His Arg Glu Ser 
    610                 615                 620                 


Trp Ser Ser Thr Lys Gly Ile Leu Ser Pro Arg Ala Pro Lys Gln Gln 
625                 630                 635                 640 


Gln His Arg Leu Ser Val Asp Ala Asn Leu Gln Ile Pro Lys Glu Leu 
                645                 650                 655     


Thr Leu Ala Ser Lys Arg Glu Leu Leu Gln Lys Thr Ser Glu Arg Leu 
            660                 665                 670         


Ala Ser Gly Glu Ile Thr Gln Asp Asp Phe Leu Val Val Val His Gln 
        675                 680                 685             


Ile Arg Gln Leu Phe Gln Tyr Gln Glu Gly Val Arg Glu Glu Gln Arg 
    690                 695                 700                 


Ser Pro Phe Asn Asp Arg Phe Pro Leu Lys Arg Pro Arg Tyr Glu Asp 
705                 710                 715                 720 


Ser Asp Lys Pro Phe Val Asp Ser Pro Ala Ser Arg Phe Ala Gly Leu 
                725                 730                 735     


Asp Thr Asn Gln Arg Leu Thr Ala Leu Ala Glu Asp Arg Pro Leu Phe 
            740                 745                 750         


Asp Gly Pro Ser Arg Pro Ser Val Ala Arg Asp Gly Pro Thr Lys Met 
        755                 760                 765             


Ile Phe Glu Gly Pro Asn Lys Leu Ser Pro Arg Ile Asp Gly Pro Pro 
    770                 775                 780                 


Thr Pro Ala Ser Leu Arg Phe Asp Gly Ser Pro Gly Gln Met Gly Gly 
785                 790                 795                 800 


Gly Gly Pro Leu Arg Phe Glu Gly Pro Gln Gly Gln Leu Gly Gly Gly 
                805                 810                 815     


Cys Pro Leu Arg Phe Glu Gly Pro Pro Gly Pro Val Gly Thr Pro Leu 
            820                 825                 830         


Arg Phe Glu Gly Pro Ile Gly Gln Ala Gly Gly Gly Gly Phe Arg Phe 
        835                 840                 845             


Glu Gly Ser Pro Gly Leu Arg Phe Glu Gly Ser Pro Gly Gly Leu Arg 
    850                 855                 860                 


Phe Glu Gly Pro Gly Gly Gln Pro Val Gly Gly Leu Arg Phe Glu Gly 
865                 870                 875                 880 


His Arg Gly Gln Pro Val Gly Gly Leu Arg Phe Glu Gly Pro His Gly 
                885                 890                 895     


Gln Pro Val Gly Gly Leu Arg Phe Asp Asn Pro Arg Gly Gln Pro Val 
            900                 905                 910         


Gly Gly Leu Arg Phe Glu Gly Gly His Gly Pro Ser Gly Ala Ala Ile 
        915                 920                 925             


Arg Phe Asp Gly Pro His Gly Gln Pro Gly Gly Gly Ile Arg Phe Glu 
    930                 935                 940                 


Gly Pro Leu Leu Gln Gln Gly Val Gly Met Arg Phe Glu Gly Pro His 
945                 950                 955                 960 


Gly Gln Ser Val Ala Gly Leu Arg Phe Glu Gly Gln His Asn Gln Leu 
                965                 970                 975     


Gly Gly Asn Leu Arg Phe Glu Gly Pro His Gly Gln Pro Gly Val Gly 
            980                 985                 990         


Ile Arg Phe Glu Gly Pro Leu Val  Gln Gln Gly Gly Gly  Met Arg Phe 
        995                 1000                 1005             


Glu Gly  Pro Ser Val Pro Gly  Gly Gly Leu Arg Ile  Glu Gly Pro 
    1010                 1015                 1020             


Leu Gly  Gln Gly Gly Pro Arg  Phe Glu Gly Cys His  Ala Leu Arg 
    1025                 1030                 1035             


Phe Asp  Gly Gln Pro Gly Gln  Pro Ser Leu Leu Pro  Arg Phe Asp 
    1040                 1045                 1050             


Gly Leu  His Gly Gln Pro Gly  Pro Arg Phe Glu Arg  Thr Pro Gly 
    1055                 1060                 1065             


Gln Pro  Gly Pro Gln Arg Phe  Asp Gly Pro Pro Gly  Gln Gln Val 
    1070                 1075                 1080             


Gln Pro  Arg Phe Asp Gly Val  Pro Gln Arg Phe Asp  Gly Pro Gln 
    1085                 1090                 1095             


His Gln  Gln Ala Ser Arg Phe  Asp Ile Pro Leu Gly  Leu Gln Gly 
    1100                 1105                 1110             


Thr Arg  Phe Asp Asn His Pro  Ser Gln Arg Leu Glu  Ser Val Ser 
    1115                 1120                 1125             


Phe Asn  Gln Thr Gly Pro Tyr  Asn Asp Pro Pro Gly  Asn Ala Phe 
    1130                 1135                 1140             


Asn Ala  Pro Ser Gln Gly Leu  Gln Phe Gln Arg His  Glu Gln Ile 
    1145                 1150                 1155             


Phe Asp  Ser Pro Gln Gly Pro  Asn Phe Asn Gly Pro  His Gly Pro 
    1160                 1165                 1170             


Gly Asn  Gln Ser Phe Ser Asn  Pro Leu Asn Arg Ala  Ser Gly His 
    1175                 1180                 1185             


Tyr Phe  Asp Glu Lys Asn Leu  Gln Ser Ser Gln Phe  Gly Asn Phe 
    1190                 1195                 1200             


Gly Asn  Ile Pro Ala Pro Met  Thr Val Gly Asn Ile  Gln Ala Ser 
    1205                 1210                 1215             


Gln Gln  Val Leu Ser Gly Val  Ala Gln Pro Val Ala  Phe Gly Gln 
    1220                 1225                 1230             


Gly Gln  Gln Phe Leu Pro Val  His Pro Gln Asn Pro  Gly Phe Val 
    1235                 1240                 1245             


Gln Asn  Pro Ser Gly Ala Leu  Pro Lys Ala Tyr Pro  Asp Asn His 
    1250                 1255                 1260             


Leu Ser  Gln Val Asp Val Asn  Glu Leu Phe Ser Lys  Leu Leu Lys 
    1265                 1270                 1275             


Thr Gly  Ile Leu Lys Leu Ser  Gln Thr Asp Ser Ala  Thr Thr Gln 
    1280                 1285                 1290             


Val Ser  Glu Val Thr Ala Gln  Pro Pro Pro Glu Glu  Glu Glu Asp 
    1295                 1300                 1305             


Gln Asn  Glu Asp Gln Asp Val  Pro Asp Leu Thr Asn  Phe Thr Val 
    1310                 1315                 1320             


Glu Glu  Leu Lys Gln Arg Tyr  Asp Ser Val Ile Asn  Arg Leu Tyr 
    1325                 1330                 1335             


Thr Gly  Ile Gln Cys Tyr Ser  Cys Gly Met Arg Phe  Thr Thr Ser 
    1340                 1345                 1350             


Gln Thr  Asp Val Tyr Ala Asp  His Leu Asp Trp His  Tyr Arg Gln 
    1355                 1360                 1365             


Asn Arg  Thr Glu Lys Asp Val  Ser Arg Lys Val Thr  His Arg Arg 
    1370                 1375                 1380             


Trp Tyr  Tyr Ser Leu Thr Asp  Trp Ile Glu Phe Glu  Glu Ile Ala 
    1385                 1390                 1395             


Asp Leu  Glu Glu Arg Ala Lys  Ser Gln Phe Phe Glu  Lys Val His 
    1400                 1405                 1410             


Glu Glu  Val Val Leu Lys Thr  Gln Glu Ala Ala Lys  Glu Lys Glu 
    1415                 1420                 1425             


Phe Gln  Ser Val Pro Ala Gly  Pro Ala Gly Ala Val  Glu Ser Cys 
    1430                 1435                 1440             


Glu Ile  Cys Gln Glu Gln Phe  Glu Gln Tyr Trp Asp  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Trp His Leu Lys Asn  Ala Ile Arg Val Asp  Gly Lys Ile 
    1460                 1465                 1470             


Tyr His  Pro Ser Cys Tyr Glu  Asp Tyr Gln Asn Thr  Ser Ser Phe 
    1475                 1480                 1485             


Asp Cys  Thr Pro Ser Pro Ser  Lys Thr Pro Val Glu  Asn Pro Leu 
    1490                 1495                 1500             


Asn Ile  Met Leu Asn Ile Val  Lys Asn Glu Leu Gln  Glu Pro Cys 
    1505                 1510                 1515             


Asp Ser  Pro Lys Val Lys Glu  Glu Arg Ile Asp Thr  Pro Pro Ala 
    1520                 1525                 1530             


Cys Thr  Glu Glu Ser Ile Ala  Thr Pro Ser Glu Ile  Lys Thr Glu 
    1535                 1540                 1545             


Asn Asp  Thr Val Glu Ser Val  
    1550                 1555 


<210>  838
<211>  2341
<212>  PRT
<213>  Homo sapiens

<400>  838

Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala 
1               5                   10                  15      


Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn 
            20                  25                  30          


Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr 
        35                  40                  45              


Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys 
    50                  55                  60                  


Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg 
65                  70                  75                  80  


Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn 
                85                  90                  95      


Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr 
            100                 105                 110         


Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu 
        115                 120                 125             


Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser 
    130                 135                 140                 


Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly 
145                 150                 155                 160 


Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr 
                165                 170                 175     


Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser 
            180                 185                 190         


Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys 
        195                 200                 205             


Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser 
    210                 215                 220                 


Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val 
225                 230                 235                 240 


Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser 
                245                 250                 255     


Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His 
            260                 265                 270         


Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser 
        275                 280                 285             


Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr 
    290                 295                 300                 


Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys 
305                 310                 315                 320 


Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser 
                325                 330                 335     


Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro 
            340                 345                 350         


Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met 
        355                 360                 365             


Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser 
    370                 375                 380                 


Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr 
385                 390                 395                 400 


Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu 
                405                 410                 415     


His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu 
            420                 425                 430         


Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg 
        435                 440                 445             


Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val 
    450                 455                 460                 


His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg 
465                 470                 475                 480 


Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala 
                485                 490                 495     


Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu 
            500                 505                 510         


Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys 
        515                 520                 525             


Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro 
    530                 535                 540                 


Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly 
545                 550                 555                 560 


Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg 
                565                 570                 575     


His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His 
            580                 585                 590         


Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu 
        595                 600                 605             


Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser 
    610                 615                 620                 


Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr 
625                 630                 635                 640 


Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser 
                645                 650                 655     


Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys 
            660                 665                 670         


Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala 
        675                 680                 685             


Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser 
    690                 695                 700                 


Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu 
                725                 730                 735     


Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser 
            740                 745                 750         


Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val 
        755                 760                 765             


Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu 
    770                 775                 780                 


Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly 
785                 790                 795                 800 


Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu 
                805                 810                 815     


Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln 
            820                 825                 830         


Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu 
        835                 840                 845             


Leu Val Arg Asn Gly Ser Val His Leu Glu Ala Ser His Asp Asn Ala 
    850                 855                 860                 


Ser Ala Val Gly Gly Ser Ser Leu His Asp Glu Leu Gly Lys Phe Ser 
865                 870                 875                 880 


Ser Thr Leu Tyr Glu Thr Gly Gly Cys Asp Met Ser Leu Val Asn Phe 
                885                 890                 895     


Glu Pro Ala Ala Arg Arg Ala Ser Asn Ile Cys Asp Thr Asp Ser His 
            900                 905                 910         


Val Ser Ser Ser Thr Ser Val Arg Phe Tyr Pro His Asp Val Leu Ser 
        915                 920                 925             


Leu Pro Gln Ile Arg Leu Asn Arg Leu Leu Thr Ile Asp Thr Asp Leu 
    930                 935                 940                 


Leu Glu Gln Gln Asp Ile Asp Leu Ser Pro Asp Leu Ala Ala Thr Tyr 
945                 950                 955                 960 


Gly Pro Thr Glu Glu Ala Ala Gln Lys Val Lys His Tyr Tyr Arg Phe 
                965                 970                 975     


Trp Ile Leu Pro Gln Leu Trp Ile Gly Ile Asn Phe Asp Arg Leu Thr 
            980                 985                 990         


Leu Leu Ala Leu Phe Asp Arg Asn  Arg Glu Ile Leu Glu  Asn Val Leu 
        995                 1000                 1005             


Ala Val  Ile Leu Ala Ile Leu  Val Ala Phe Leu Gly  Ser Ile Leu 
    1010                 1015                 1020             


Leu Ile  Gln Gly Phe Phe Arg  Asp Ile Trp Val Phe  Gln Phe Cys 
    1025                 1030                 1035             


Leu Val  Ile Ala Ser Cys Gln  Tyr Ser Leu Leu Lys  Ser Val Gln 
    1040                 1045                 1050             


Pro Asp  Ser Ser Ser Pro Arg  His Gly His Asn Arg  Ile Ile Ala 
    1055                 1060                 1065             


Tyr Ser  Arg Pro Val Tyr Phe  Cys Ile Cys Cys Gly  Leu Ile Trp 
    1070                 1075                 1080             


Leu Leu  Asp Tyr Gly Ser Arg  Asn Leu Thr Ala Thr  Lys Phe Lys 
    1085                 1090                 1095             


Leu Tyr  Gly Ile Thr Phe Thr  Asn Pro Leu Val Phe  Ile Ser Ala 
    1100                 1105                 1110             


Arg Asp  Leu Val Ile Val Phe  Thr Leu Cys Phe Pro  Ile Val Phe 
    1115                 1120                 1125             


Phe Ile  Gly Leu Leu Pro Gln  Val Asn Thr Phe Val  Met Tyr Leu 
    1130                 1135                 1140             


Cys Glu  Gln Leu Asp Ile His  Ile Phe Gly Gly Asn  Ala Thr Thr 
    1145                 1150                 1155             


Ser Leu  Leu Ala Ala Leu Tyr  Ser Phe Ile Cys Ser  Ile Val Ala 
    1160                 1165                 1170             


Val Ala  Leu Leu Tyr Gly Leu  Cys Tyr Gly Ala Leu  Lys Asp Ser 
    1175                 1180                 1185             


Trp Asp  Gly Gln His Ile Pro  Val Leu Phe Ser Ile  Phe Cys Gly 
    1190                 1195                 1200             


Leu Leu  Val Ala Val Ser Tyr  His Leu Ser Arg Gln  Ser Ser Asp 
    1205                 1210                 1215             


Pro Ser  Val Leu Phe Ser Leu  Val Gln Ser Lys Ile  Phe Pro Lys 
    1220                 1225                 1230             


Thr Glu  Glu Lys Asn Pro Glu  Asp Pro Leu Ser Glu  Val Lys Asp 
    1235                 1240                 1245             


Pro Leu  Pro Glu Lys Leu Arg  Asn Ser Val Ser Glu  Arg Leu Gln 
    1250                 1255                 1260             


Ser Asp  Leu Val Val Cys Ile  Val Ile Gly Val Leu  Tyr Phe Ala 
    1265                 1270                 1275             


Ile His  Val Ser Thr Val Phe  Thr Val Leu Gln Pro  Ala Leu Lys 
    1280                 1285                 1290             


Tyr Val  Leu Tyr Thr Leu Val  Gly Phe Val Gly Phe  Val Thr His 
    1295                 1300                 1305             


Tyr Val  Leu Pro Gln Val Arg  Lys Gln Leu Pro Trp  His Cys Phe 
    1310                 1315                 1320             


Ser His  Pro Leu Leu Lys Thr  Leu Glu Tyr Asn Gln  Tyr Glu Val 
    1325                 1330                 1335             


Arg Asn  Ala Ala Thr Met Met  Trp Phe Glu Lys Leu  His Val Trp 
    1340                 1345                 1350             


Leu Leu  Phe Val Glu Lys Asn  Ile Ile Tyr Pro Leu  Ile Val Leu 
    1355                 1360                 1365             


Asn Glu  Leu Ser Ser Ser Ala  Glu Thr Ile Ala Ser  Pro Lys Lys 
    1370                 1375                 1380             


Leu Asn  Thr Glu Leu Gly Ala  Leu Met Ile Thr Val  Ala Gly Leu 
    1385                 1390                 1395             


Lys Leu  Leu Arg Ser Ser Phe  Ser Ser Pro Thr Tyr  Gln Tyr Val 
    1400                 1405                 1410             


Thr Val  Ile Phe Thr Val Leu  Phe Phe Lys Phe Asp  Tyr Glu Ala 
    1415                 1420                 1425             


Phe Ser  Glu Thr Met Leu Leu  Asp Leu Phe Phe Met  Ser Ile Leu 
    1430                 1435                 1440             


Phe Asn  Lys Leu Trp Glu Leu  Leu Tyr Lys Leu Gln  Phe Val Tyr 
    1445                 1450                 1455             


Thr Tyr  Ile Ala Pro Trp Gln  Ile Thr Trp Gly Ser  Ala Phe His 
    1460                 1465                 1470             


Ala Phe  Ala Gln Pro Phe Ala  Val Pro His Ser Ala  Met Leu Phe 
    1475                 1480                 1485             


Ile Gln  Ala Ala Val Ser Ala  Phe Phe Ser Thr Pro  Leu Asn Pro 
    1490                 1495                 1500             


Phe Leu  Gly Ser Ala Ile Phe  Ile Thr Ser Tyr Val  Arg Pro Val 
    1505                 1510                 1515             


Lys Phe  Trp Glu Arg Asp Tyr  Asn Thr Lys Arg Val  Asp His Ser 
    1520                 1525                 1530             


Asn Thr  Arg Leu Ala Ser Gln  Leu Asp Arg Asn Pro  Gly Ser Asp 
    1535                 1540                 1545             


Asp Asn  Asn Leu Asn Ser Ile  Phe Tyr Glu His Leu  Thr Arg Ser 
    1550                 1555                 1560             


Leu Gln  His Ser Leu Cys Gly  Asp Leu Leu Leu Gly  Arg Trp Gly 
    1565                 1570                 1575             


Asn Tyr  Ser Thr Gly Asp Cys  Phe Ile Leu Ala Ser  Asp Tyr Leu 
    1580                 1585                 1590             


Asn Ala  Leu Val His Leu Ile  Glu Ile Gly Asn Gly  Leu Val Thr 
    1595                 1600                 1605             


Phe Gln  Leu Arg Gly Leu Glu  Phe Arg Gly Thr Tyr  Cys Gln Gln 
    1610                 1615                 1620             


Arg Glu  Val Glu Ala Ile Thr  Glu Gly Val Glu Glu  Asp Glu Gly 
    1625                 1630                 1635             


Phe Cys  Cys Cys Glu Pro Gly  His Ile Pro His Met  Leu Ser Phe 
    1640                 1645                 1650             


Asn Ala  Ala Phe Ser Gln Arg  Trp Leu Ala Trp Glu  Val Ile Val 
    1655                 1660                 1665             


Thr Lys  Tyr Ile Leu Glu Gly  Tyr Ser Ile Thr Asp  Asn Ser Ala 
    1670                 1675                 1680             


Ala Ser  Met Leu Gln Val Phe  Asp Leu Arg Lys Val  Leu Thr Thr 
    1685                 1690                 1695             


Tyr Tyr  Val Lys Gly Ile Ile  Tyr Tyr Val Thr Thr  Ser Ser Lys 
    1700                 1705                 1710             


Leu Glu  Glu Trp Leu Ala Asn  Glu Thr Met Gln Glu  Gly Leu Arg 
    1715                 1720                 1725             


Leu Cys  Ala Asp Arg Asn Tyr  Val Asp Val Asp Pro  Thr Phe Asn 
    1730                 1735                 1740             


Pro Asn  Ile Asp Glu Asp Tyr  Asp His Arg Leu Ala  Gly Ile Ser 
    1745                 1750                 1755             


Arg Glu  Ser Phe Cys Val Ile  Tyr Leu Asn Trp Ile  Glu Tyr Cys 
    1760                 1765                 1770             


Ser Ser  Arg Arg Ala Lys Pro  Val Asp Val Asp Lys  Asp Ser Ser 
    1775                 1780                 1785             


Leu Val  Thr Leu Cys Tyr Gly  Leu Cys Val Leu Gly  Arg Arg Ala 
    1790                 1795                 1800             


Leu Gly  Thr Ala Ser His His  Met Ser Ser Asn Leu  Glu Ser Phe 
    1805                 1810                 1815             


Leu Tyr  Gly Leu His Ala Leu  Phe Lys Gly Asp Phe  Arg Ile Ser 
    1820                 1825                 1830             


Ser Ile  Arg Asp Glu Trp Ile  Phe Ala Asp Met Glu  Leu Leu Arg 
    1835                 1840                 1845             


Lys Val  Val Val Pro Gly Ile  Arg Met Ser Ile Lys  Leu His Gln 
    1850                 1855                 1860             


Asp His  Phe Thr Ser Pro Asp  Glu Tyr Asp Asp Pro  Thr Val Leu 
    1865                 1870                 1875             


Tyr Glu  Ala Ile Val Ser His  Glu Lys Asn Leu Val  Ile Ala His 
    1880                 1885                 1890             


Glu Gly  Asp Pro Ala Trp Arg  Ser Ala Val Leu Ala  Asn Ser Pro 
    1895                 1900                 1905             


Ser Leu  Leu Ala Leu Arg His  Val Met Asp Asp Gly  Thr Asn Glu 
    1910                 1915                 1920             


Tyr Lys  Ile Ile Met Leu Asn  Arg Arg Tyr Leu Ser  Phe Arg Val 
    1925                 1930                 1935             


Ile Lys  Val Asn Lys Glu Cys  Val Arg Gly Leu Trp  Ala Gly Gln 
    1940                 1945                 1950             


Gln Gln  Glu Leu Val Phe Leu  Arg Asn Arg Asn Pro  Glu Arg Gly 
    1955                 1960                 1965             


Ser Ile  Gln Asn Ala Lys Gln  Ala Leu Arg Asn Met  Ile Asn Ser 
    1970                 1975                 1980             


Ser Cys  Asp Gln Pro Ile Gly  Tyr Pro Ile Phe Val  Ser Pro Leu 
    1985                 1990                 1995             


Thr Thr  Ser Tyr Ser Asp Ser  His Glu Gln Leu Lys  Asp Ile Leu 
    2000                 2005                 2010             


Gly Gly  Pro Ile Ser Leu Gly  Asn Ile Arg Asn Phe  Ile Val Ser 
    2015                 2020                 2025             


Thr Trp  His Arg Leu Arg Lys  Gly Cys Gly Ala Gly  Cys Asn Ser 
    2030                 2035                 2040             


Gly Gly  Asn Ile Glu Asp Ser  Asp Thr Gly Gly Gly  Thr Ser Cys 
    2045                 2050                 2055             


Thr Gly  Asn Asn Ala Thr Thr  Ala Asn Asn Pro His  Ser Asn Val 
    2060                 2065                 2070             


Thr Gln  Gly Ser Ile Gly Asn  Pro Gly Gln Gly Ser  Gly Thr Gly 
    2075                 2080                 2085             


Leu His  Pro Pro Val Thr Ser  Tyr Pro Pro Thr Leu  Gly Thr Ser 
    2090                 2095                 2100             


His Ser  Ser His Ser Val Gln  Ser Gly Leu Val Arg  Gln Ser Pro 
    2105                 2110                 2115             


Ala Arg  Ala Ser Val Ala Ser  Gln Ser Ser Tyr Cys  Tyr Ser Ser 
    2120                 2125                 2130             


Arg His  Ser Ser Leu Arg Met  Ser Thr Thr Gly Phe  Val Pro Cys 
    2135                 2140                 2145             


Arg Arg  Ser Ser Thr Ser Gln  Ile Ser Leu Arg Asn  Leu Pro Ser 
    2150                 2155                 2160             


Ser Ile  Gln Ser Arg Leu Ser  Met Val Asn Gln Met  Glu Pro Ser 
    2165                 2170                 2175             


Gly Gln  Ser Gly Leu Ala Cys  Val Gln His Gly Leu  Pro Ser Ser 
    2180                 2185                 2190             


Ser Ser  Ser Ser Gln Ser Ile  Pro Ala Cys Lys His  His Thr Leu 
    2195                 2200                 2205             


Val Gly  Phe Leu Ala Thr Glu  Gly Gly Gln Ser Ser  Ala Thr Asp 
    2210                 2215                 2220             


Ala Gln  Pro Gly Asn Thr Leu  Ser Pro Ala Asn Asn  Ser His Ser 
    2225                 2230                 2235             


Arg Lys  Ala Glu Val Ile Tyr  Arg Val Gln Ile Val  Asp Pro Ser 
    2240                 2245                 2250             


Gln Ile  Leu Glu Gly Ile Asn  Leu Ser Lys Arg Lys  Glu Leu Gln 
    2255                 2260                 2265             


Trp Pro  Asp Glu Gly Ile Arg  Leu Lys Ala Gly Arg  Asn Ser Trp 
    2270                 2275                 2280             


Lys Asp  Trp Ser Pro Gln Glu  Gly Met Glu Gly His  Val Ile His 
    2285                 2290                 2295             


Arg Trp  Val Pro Cys Ser Arg  Asp Pro Gly Thr Arg  Ser His Ile 
    2300                 2305                 2310             


Asp Lys  Ala Val Leu Leu Val  Gln Ile Asp Asp Lys  Tyr Val Thr 
    2315                 2320                 2325             


Val Ile  Glu Thr Gly Val Leu  Glu Leu Gly Ala Glu  Val 
    2330                 2335                 2340     


<210>  839
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  839

Met Ala Thr Phe Ile Ser Val Gln Leu Lys Lys Thr Ser Glu Val Asp 
1               5                   10                  15      


Leu Ala Lys Pro Leu Val Lys Phe Ile Gln Gln Thr Tyr Pro Ser Gly 
            20                  25                  30          


Gly Glu Glu Gln Ala Gln Tyr Cys Arg Ala Ala Glu Glu Leu Ser Lys 
        35                  40                  45              


Leu Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His Glu Gly Ala 
    50                  55                  60                  


Leu Glu Thr Leu Leu Arg Tyr Tyr Asp Gln Ile Cys Ser Ile Glu Pro 
65                  70                  75                  80  


Lys Phe Pro Phe Ser Glu Asn Gln Ile Cys Leu Thr Phe Thr Trp Lys 
                85                  90                  95      


Asp Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val Lys Leu Ala 
            100                 105                 110         


Leu Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe Asn Cys Ala 
        115                 120                 125             


Ala Leu Ala Ser Gln Ile Ala Ala Glu Gln Asn Leu Asp Asn Asp Glu 
    130                 135                 140                 


Gly Leu Lys Ile Ala Ala Lys His Tyr Gln Phe Ala Ser Gly Ala Phe 
145                 150                 155                 160 


Leu His Ile Lys Glu Thr Val Leu Ser Ala Leu Ser Arg Glu Pro Thr 
                165                 170                 175     


Val Asp Ile Ser Pro Asp Thr Val Gly Thr Leu Ser Leu Ile Met Leu 
            180                 185                 190         


Ala Gln Ala Gln Glu Val Phe Phe Leu Lys Ala Thr Arg Asp Lys Met 
        195                 200                 205             


Lys Asp Ala Ile Ile Ala Lys Leu Ala Asn Gln Ala Ala Asp Tyr Phe 
    210                 215                 220                 


Gly Asp Ala Phe Lys Gln Cys Gln Tyr Lys Asp Thr Leu Pro Lys Glu 
225                 230                 235                 240 


Val Phe Pro Val Leu Ala Ala Lys His Cys Ile Met Gln Ala Asn Ala 
                245                 250                 255     


Glu Tyr His Gln Ser Ile Leu Ala Lys Gln Gln Lys Lys Phe Gly Glu 
            260                 265                 270         


Glu Ile Ala Arg Leu Gln His Ala Ala Glu Leu Ile Lys Thr Val Ala 
        275                 280                 285             


Ser Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser Asp Lys Ile 
    290                 295                 300                 


Asn Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe Ile Tyr His 
305                 310                 315                 320 


Asp Arg Val Pro Asp Leu Lys Asp Leu Asp Pro Ile Gly Lys Ala Thr 
                325                 330                 335     


Leu Val Lys Ser Thr Pro Val Asn Val Pro Ile Ser Gln Lys Phe Thr 
            340                 345                 350         


Asp Leu Phe Glu Lys Met Val Pro Val Ser Val Gln Gln Ser Leu Ala 
        355                 360                 365             


Ala Tyr Asn Gln Arg Lys Ala Asp Leu Val Asn Arg Ser Ile Ala Gln 
    370                 375                 380                 


Met Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala Ser Leu Asn 
385                 390                 395                 400 


Leu Pro Ala Ala Ile Glu Asp Val Ser Gly Asp Thr Val Pro Gln Ser 
                405                 410                 415     


Ile Leu Thr Lys Ser Arg Ser Val Ile Glu Gln Gly Gly Ile Gln Thr 
            420                 425                 430         


Val Asp Gln Leu Ile Lys Glu Leu Pro Glu Leu Leu Gln Arg Asn Arg 
        435                 440                 445             


Glu Ile Leu Asp Glu Ser Leu Arg Leu Leu Asp Glu Glu Glu Ala Thr 
    450                 455                 460                 


Asp Asn Asp Leu Arg Ala Lys Phe Lys Glu Arg Trp Gln Arg Thr Pro 
465                 470                 475                 480 


Ser Asn Glu Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr Asn Phe Arg 
                485                 490                 495     


Thr Val Leu Asp Lys Ala Val Gln Ala Asp Gly Gln Val Lys Glu Cys 
            500                 505                 510         


Tyr Gln Ser His Arg Asp Thr Ile Val Leu Leu Cys Lys Pro Glu Pro 
        515                 520                 525             


Glu Leu Asn Ala Ala Ile Pro Ser Ala Asn Pro Ala Lys Thr Met Gln 
    530                 535                 540                 


Gly Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser Asn Leu Asp 
545                 550                 555                 560 


Glu Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu Lys Ser Val 
                565                 570                 575     


Asn Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala Gln Asp Gly 
            580                 585                 590         


Val Ile Asn Glu Glu Ala Leu Ser Val Thr Glu Leu Asp Arg Val Tyr 
        595                 600                 605             


Gly Gly Leu Thr Thr Lys Val Gln Glu Ser Leu Lys Lys Gln Glu Gly 
    610                 615                 620                 


Leu Leu Lys Asn Ile Gln Val Ser His Gln Glu Phe Ser Lys Met Lys 
625                 630                 635                 640 


Gln Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu Lys Asn Leu 
                645                 650                 655     


Ala Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn Leu Lys Glu 
            660                 665                 670         


Gly Thr Lys Phe Tyr Asn Glu Leu Thr Glu Ile Leu Val Arg Phe Gln 
        675                 680                 685             


Asn Lys Cys Ser Asp Ile Val Phe Ala Arg Lys Thr Glu Arg Asp Glu 
    690                 695                 700                 


Leu Leu Lys Asp Leu Gln Gln Ser Ile Ala Arg Glu Pro Ser Ala Pro 
705                 710                 715                 720 


Ser Ile Pro Thr Pro Ala Tyr Gln Ser Ser Pro Ala Gly Gly His Ala 
                725                 730                 735     


Pro Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro Thr Lys Pro 
            740                 745                 750         


Gln Pro Pro Ala Arg Pro Pro Pro Pro Val Leu Pro Ala Asn Arg Ala 
        755                 760                 765             


Pro Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr Ala Ala Pro 
    770                 775                 780                 


Ala Pro Ser Gln Thr Pro Gly Ser Ala Pro Pro Pro Gln Ala Gln Gly 
785                 790                 795                 800 


Pro Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys Gln Met Pro 
                805                 810                 815     


Met Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gln Tyr Asn Met Pro 
            820                 825                 830         


Tyr Pro Pro Val Tyr His Gln Ser Pro Gly Gln Ala Pro Tyr Pro Gly 
        835                 840                 845             


Pro Gln Gln Pro Ser Tyr Pro Phe Pro Gln Pro Pro Gln Gln Ser Tyr 
    850                 855                 860                 


Tyr Pro Gln Gln 
865             


<210>  840
<211>  1112
<212>  PRT
<213>  Homo sapiens

<400>  840

Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      


Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          


Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              


Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  


Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  


Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      


Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         


Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             


Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 


Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 


Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     


Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         


Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             


Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 


Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 


Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     


Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         


Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             


Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 


Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 


Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     


Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         


Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             


Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 


Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 


Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     


Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         


Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             


Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 


His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 


Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     


Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         


Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             


Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 


Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 


Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     


Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         


Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             


Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 


Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 


Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     


Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         


Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             


Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 


Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 


Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     


His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         


Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             


Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 


Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 


Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     


Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         


Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             


Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 


Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 


Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     


Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         


Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             


Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 


Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 


Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         


Thr His Ile Val Gly Pro Leu Cys  Asn Ser Tyr Asp Ala  Ala Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Gln Trp Leu Glu  Ala Glu Glu Asp Asn  Asp Thr Glu 
    1010                 1015                 1020             


Ser Gly  Asp Asp Glu Asp Gly  Glu Glu Leu Asp Thr  Glu Asp Glu 
    1025                 1030                 1035             


Glu Met  Glu Asn Asn Leu Asn  Pro Lys Pro Pro Arg  Arg Lys Ser 
    1040                 1045                 1050             


Arg Arg  Arg Ile Phe Cys Gln  Leu Met His His Leu  Thr Glu Asn 
    1055                 1060                 1065             


His Lys  Ile Trp Lys Glu Ile  Val Glu Glu Glu Glu  Lys Cys Lys 
    1070                 1075                 1080             


Ala Asp  Gly Asn Lys Leu Gln  Val Glu Asn Ser Ser  Leu Pro Gln 
    1085                 1090                 1095             


Ala Asp  Glu Ile Gln Val Ile  Glu Glu Ala Asp Glu  Glu Glu 
    1100                 1105                 1110         


<210>  841
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  841

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  842
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Ala Gln Ser Ile Asn Ile Thr Glu Leu Asn Leu Pro Gln Leu Glu 
1               5                   10                  15      


Met Leu Lys Asn Gln Leu Asp Gln Glu Val Glu Phe Leu Ser Thr Ser 
            20                  25                  30          


Ile Ala Gln Leu Lys Val Val Gln Thr Lys Tyr Val Glu Ala Lys Asp 
        35                  40                  45              


Cys Leu Asn Val Leu Asn Lys Ser Asn Glu Gly Lys Glu Leu Leu Val 
    50                  55                  60                  


Pro Leu Thr Ser Ser Met Tyr Val Pro Gly Lys Leu His Asp Val Glu 
65                  70                  75                  80  


His Val Leu Ile Asp Val Gly Thr Gly Tyr Tyr Val Glu Lys Thr Ala 
                85                  90                  95      


Glu Asp Ala Lys Asp Phe Phe Lys Arg Lys Ile Asp Phe Leu Thr Lys 
            100                 105                 110         


Gln Met Glu Lys Ile Gln Pro Ala Leu Gln Glu Lys His Ala Met Lys 
        115                 120                 125             


Gln Ala Val Met Glu Met Met Ser Gln Lys Ile Gln Gln Leu Thr Ala 
    130                 135                 140                 


Leu Gly Ala Ala Gln Ala Thr Ala Lys Ala 
145                 150                 


<210>  843
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  843

Met Ala Val Ala Ala Ala Ala Ala Ala Gly Pro Val Phe Trp Arg Arg 
1               5                   10                  15      


Leu Leu Gly Leu Leu Pro Gly Arg Pro Gly Leu Ala Ala Leu Leu Gly 
            20                  25                  30          


Arg Leu Ser Asp Arg Leu Gly Arg Asn Arg Asp Arg Gln Arg Arg Arg 
        35                  40                  45              


Ser Pro Trp Leu Leu Leu Ala Pro Leu Leu Ser Pro Ala Val Pro Gln 
    50                  55                  60                  


Val Thr Ser Pro Pro Cys Cys Leu Cys Pro Glu Gly Val His Arg Phe 
65                  70                  75                  80  


Gln Trp Ile Arg Asn Leu Val Pro Glu Phe Gly Val Ser Ser Ser His 
                85                  90                  95      


Val Arg Val Leu Ser Ser Pro Ala Glu Phe Phe Glu Leu Met Lys Gly 
            100                 105                 110         


Gln Ile Arg Val Ala Lys Arg Arg Val Val Met Ala Ser Leu Tyr Leu 
        115                 120                 125             


Gly Thr Gly Pro Leu Glu Gln Glu Leu Val Asp Cys Leu Glu Ser Thr 
    130                 135                 140                 


Leu Glu Lys Ser Leu Gln Ala Lys Phe Pro Ser Asn Leu Lys Val Ser 
145                 150                 155                 160 


Ile Leu Leu Asp Phe Thr Arg Gly Ser Arg Gly Arg Lys Asn Ser Arg 
                165                 170                 175     


Thr Met Leu Leu Pro Leu Leu Arg Arg Phe Pro Glu Gln Val Arg Val 
            180                 185                 190         


Ser Leu Phe His Thr Pro His Leu Arg Gly Leu Leu Arg Leu Leu Ile 
        195                 200                 205             


Pro Glu Arg Phe Asn Glu Thr Ile Gly Leu Gln His Ile Lys Val Tyr 
    210                 215                 220                 


Leu Phe Asp Asn Ser Val Ile Leu Ser Gly Ala Asn Leu Ser Asp Ser 
225                 230                 235                 240 


Tyr Phe Thr Asn Arg Gln Asp Arg Tyr Val Phe Leu Gln Asp Cys Ala 
                245                 250                 255     


Glu Ile Ala Asp Phe Phe Thr Glu Leu Val Asp Ala Val Gly Asp Val 
            260                 265                 270         


Ser Leu Gln Leu Gln Gly Asp Asp Thr Val Gln Val Val Asp Gly Met 
        275                 280                 285             


Val His Pro Tyr Lys Gly Asp Arg Ala Glu Tyr Cys Lys Ala Ala Asn 
    290                 295                 300                 


Lys Arg Val Met Asp Val Ile Asn Ser Ala Arg Thr Arg Gln Gln Met 
305                 310                 315                 320 


Leu His Ala Gln Thr Phe His Ser Asn Ser Leu Leu Thr Gln Glu Asp 
                325                 330                 335     


Ala Ala Ala Ala Gly Asp Arg Arg Pro Ala Pro Asp Thr Trp Ile Tyr 
            340                 345                 350         


Pro Leu Ile Gln Met Lys Pro Phe Glu Ile Gln Ile Asp Glu Ile Val 
        355                 360                 365             


Thr Glu Thr Leu Leu Thr Glu Ala Glu Arg Gly Ala Lys Val Tyr Leu 
    370                 375                 380                 


Thr Thr Gly Tyr Phe Asn Leu Thr Gln Ala Tyr Met Asp Leu Val Leu 
385                 390                 395                 400 


Gly Thr Arg Ala Glu Tyr Gln Ile Leu Leu Ala Ser Pro Glu Val Asn 
                405                 410                 415     


Gly Phe Phe Gly Ala Lys Gly Val Ala Gly Ala Ile Pro Ala Ala Tyr 
            420                 425                 430         


Val His Ile Glu Arg Gln Phe Phe Ser Glu Val Cys Ser Leu Gly Gln 
        435                 440                 445             


Gln Glu Arg Val Gln Leu Gln Glu Tyr Trp Arg Arg Gly Trp Thr Phe 
    450                 455                 460                 


His Ala Lys Gly Leu Trp Leu Tyr Leu Ala Gly Ser Ser Leu Pro Cys 
465                 470                 475                 480 


Leu Thr Leu Ile Gly Ser Pro Asn Phe Gly Tyr Arg Ser Val His Arg 
                485                 490                 495     


Asp Leu Glu Ala Gln Ile Ala Ile Val Thr Glu Asn Gln Ala Leu Gln 
            500                 505                 510         


Gln Gln Leu His Gln Glu Gln Glu Gln Leu Tyr Leu Arg Ser Gly Val 
        515                 520                 525             


Val Ser Ser Ala Thr Phe Glu Gln Pro Ser Arg Gln Val Lys Leu Trp 
    530                 535                 540                 


Val Lys Met Val Thr Pro Leu Ile Lys Asn Phe Phe 
545                 550                 555     


<210>  844
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  844

Met Thr Ser Gly Asn Gly Asn Ser Ala Ser Ser Ile Ala Gly Thr Ala 
1               5                   10                  15      


Pro Gln Asn Gly Glu Asn Lys Pro Pro Gln Ala Ile Val Lys Pro Gln 
            20                  25                  30          


Ile Leu Thr His Val Ile Glu Gly Phe Val Ile Gln Glu Gly Ala Glu 
        35                  40                  45              


Pro Phe Pro Val Gly Arg Ser Ser Leu Leu Val Gly Asn Leu Lys Lys 
    50                  55                  60                  


Lys Tyr Ala Gln Gly Phe Leu Pro Glu Lys Leu Pro Gln Gln Asp His 
65                  70                  75                  80  


Thr Thr Thr Thr Asp Ser Glu Met Glu Glu Pro Tyr Leu Gln Glu Ser 
                85                  90                  95      


Lys Glu Glu Gly Ala Pro Leu Lys Leu Lys Cys Glu Leu Cys Gly Arg 
            100                 105                 110         


Val Asp Phe Ala Tyr Lys Phe Lys Arg Ser Lys Arg Phe Cys Ser Met 
        115                 120                 125             


Ala Cys Ala Lys Arg Tyr Asn Val Gly Cys Thr Lys Arg Val Gly Leu 
    130                 135                 140                 


Phe His Ser Asp Arg Ser Lys Leu Gln Lys Ala Gly Ala Ala Thr His 
145                 150                 155                 160 


Asn Arg Arg Arg Ala Ser Lys Ala Ser Leu Pro Pro Leu Thr Lys Asp 
                165                 170                 175     


Thr Lys Lys Gln Pro Thr Gly Thr Val Pro Leu Ser Val Thr Ala Ala 
            180                 185                 190         


Leu Gln Leu Thr His Ser Gln Glu Asp Ser Ser Arg Cys Ser Asp Asn 
        195                 200                 205             


Ser Ser Tyr Glu Glu Pro Leu Ser Pro Ile Ser Ala Ser Ser Ser Thr 
    210                 215                 220                 


Ser Arg Arg Arg Gln Gly Gln Arg Asp Leu Glu Leu Pro Asp Met His 
225                 230                 235                 240 


Met Arg Asp Leu Val Gly Met Gly His His Phe Leu Pro Ser Glu Pro 
                245                 250                 255     


Thr Lys Trp Asn Val Glu Asp Val Tyr Glu Phe Ile Arg Ser Leu Pro 
            260                 265                 270         


Gly Cys Gln Glu Ile Ala Glu Glu Phe Arg Ala Gln Glu Ile Asp Gly 
        275                 280                 285             


Gln Ala Leu Leu Leu Leu Lys Glu Asp His Leu Met Ser Ala Met Asn 
    290                 295                 300                 


Ile Lys Leu Gly Pro Ala Leu Lys Ile Tyr Ala Arg Ile Ser Met Leu 
305                 310                 315                 320 


Lys Asp Ser 
            


<210>  845
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  845

Met Ala Gln Ala Ser Pro Pro Arg Pro Glu Arg Val Leu Gly Ala Ser 
1               5                   10                  15      


Ser Pro Glu Ala Arg Pro Ala Gln Glu Ala Leu Leu Leu Pro Thr Gly 
            20                  25                  30          


Val Phe Gln Val Ala Glu Lys Met Glu Lys Arg Thr Cys Ala Leu Cys 
        35                  40                  45              


Pro Lys Asp Val Glu Tyr Asn Val Leu Tyr Phe Ala Gln Ser Glu Asn 
    50                  55                  60                  


Ile Ala Ala His Glu Asn Cys Leu Leu Tyr Ser Ser Gly Leu Val Glu 
65                  70                  75                  80  


Cys Glu Asp Gln Asp Pro Leu Asn Pro Asp Arg Ser Phe Asp Val Glu 
                85                  90                  95      


Ser Val Lys Lys Glu Ile Gln Arg Gly Arg Lys Leu Lys Cys Lys Phe 
            100                 105                 110         


Cys His Lys Arg Gly Ala Thr Val Gly Cys Asp Leu Lys Asn Cys Asn 
        115                 120                 125             


Lys Asn Tyr His Phe Phe Cys Ala Lys Lys Asp Asp Ala Val Pro Gln 
    130                 135                 140                 


Ser Asp Gly Val Arg Gly Ile Tyr Lys Leu Leu Cys Gln Gln His Ala 
145                 150                 155                 160 


Gln Phe Pro Ile Ile Ala Gln Ser Ala Lys Phe Ser Gly Val Lys Arg 
                165                 170                 175     


Lys Arg Gly Arg Lys Lys Pro Leu Ser Gly Asn His Val Gln Pro Pro 
            180                 185                 190         


Glu Thr Met Lys Cys Asn Thr Phe Ile Arg Gln Val Lys Glu Glu His 
        195                 200                 205             


Gly Arg His Thr Asp Ala Thr Val Lys Val Pro Phe Leu Lys Lys Cys 
    210                 215                 220                 


Lys Glu Ala Gly Leu Leu Asn Tyr Leu Leu Glu Glu Ile Leu Asp Lys 
225                 230                 235                 240 


Val His Ser Ile Pro Glu Lys Leu Met Asp Glu Thr Thr Ser Glu Ser 
                245                 250                 255     


Asp Tyr Glu Glu Ile Gly Ser Ala Leu Phe Asp Cys Arg Leu Phe Glu 
            260                 265                 270         


Asp Thr Phe Val Asn Phe Gln Ala Ala Ile Glu Lys Lys Ile His Ala 
        275                 280                 285             


Ser Gln Gln Arg Trp Gln Gln Leu Lys Glu Glu Ile Glu Leu Leu Gln 
    290                 295                 300                 


Asp Leu Lys Gln Thr Leu Cys Ser Phe Gln Glu Asn Arg Asp Leu Met 
305                 310                 315                 320 


Ser Ser Ser Thr Ser Ile Ser Ser Leu Ser Tyr 
                325                 330     


<210>  846
<211>  1096
<212>  PRT
<213>  Homo sapiens

<400>  846

Met Ala Thr Val Pro Val Tyr Cys Val Cys Arg Leu Pro Tyr Asp Val 
1               5                   10                  15      


Thr Arg Phe Met Ile Glu Cys Asp Ala Cys Lys Asp Trp Phe His Gly 
            20                  25                  30          


Ser Cys Val Gly Val Glu Glu Glu Glu Ala Pro Asp Ile Asp Ile Tyr 
        35                  40                  45              


His Cys Pro Asn Cys Glu Lys Thr His Gly Lys Ser Thr Leu Lys Lys 
    50                  55                  60                  


Lys Arg Thr Trp His Lys His Gly Pro Gly Gln Ala Pro Asp Val Lys 
65                  70                  75                  80  


Pro Val Gln Asn Gly Ser Gln Leu Phe Ile Lys Glu Leu Arg Ser Arg 
                85                  90                  95      


Thr Phe Pro Ser Ala Glu Asp Val Val Ala Arg Val Pro Gly Ser Gln 
            100                 105                 110         


Leu Thr Leu Gly Tyr Met Glu Glu His Gly Phe Thr Glu Pro Ile Leu 
        115                 120                 125             


Val Pro Lys Lys Asp Gly Leu Gly Leu Ala Val Pro Ala Pro Thr Phe 
    130                 135                 140                 


Tyr Val Ser Asp Val Glu Asn Tyr Val Gly Pro Glu Arg Ser Val Asp 
145                 150                 155                 160 


Val Thr Asp Val Thr Lys Gln Lys Asp Cys Lys Met Lys Leu Lys Glu 
                165                 170                 175     


Phe Val Asp Tyr Tyr Tyr Ser Thr Asn Arg Lys Arg Val Leu Asn Val 
            180                 185                 190         


Thr Asn Leu Glu Phe Ser Asp Thr Arg Met Ser Ser Phe Val Glu Pro 
        195                 200                 205             


Pro Asp Ile Val Lys Lys Leu Ser Trp Val Glu Asn Tyr Trp Pro Asp 
    210                 215                 220                 


Asp Ala Leu Leu Ala Lys Pro Lys Val Thr Lys Tyr Cys Leu Ile Cys 
225                 230                 235                 240 


Val Lys Asp Ser Tyr Thr Asp Phe His Ile Asp Ser Gly Gly Ala Ser 
                245                 250                 255     


Ala Trp Tyr His Val Leu Lys Gly Glu Lys Thr Phe Tyr Leu Ile Arg 
            260                 265                 270         


Pro Ala Ser Ala Asn Ile Ser Leu Tyr Glu Arg Trp Arg Ser Ala Ser 
        275                 280                 285             


Asn His Ser Glu Met Phe Phe Ala Asp Gln Val Asp Lys Cys Tyr Lys 
    290                 295                 300                 


Cys Ile Val Lys Gln Gly Gln Thr Leu Phe Ile Pro Ser Gly Trp Ile 
305                 310                 315                 320 


Tyr Ala Thr Leu Thr Pro Val Asp Cys Leu Ala Phe Ala Gly His Phe 
                325                 330                 335     


Leu His Ser Leu Ser Val Glu Met Gln Met Arg Ala Tyr Glu Val Glu 
            340                 345                 350         


Arg Arg Leu Lys Leu Gly Ser Leu Thr Gln Phe Pro Asn Phe Glu Thr 
        355                 360                 365             


Ala Cys Trp Tyr Met Gly Lys His Leu Leu Glu Ala Phe Lys Gly Ser 
    370                 375                 380                 


His Lys Ser Gly Lys Gln Leu Pro Pro His Leu Val Gln Gly Ala Lys 
385                 390                 395                 400 


Ile Leu Asn Gly Ala Phe Arg Ser Trp Thr Lys Lys Gln Ala Leu Ala 
                405                 410                 415     


Glu His Glu Asp Glu Leu Pro Glu His Phe Lys Pro Ser Gln Leu Ile 
            420                 425                 430         


Lys Asp Leu Ala Lys Glu Ile Arg Leu Ser Glu Asn Ala Ser Lys Ala 
        435                 440                 445             


Val Arg Pro Glu Val Asn Thr Val Ala Ser Ser Asp Glu Val Cys Asp 
    450                 455                 460                 


Gly Asp Arg Glu Lys Glu Glu Pro Pro Ser Pro Ile Glu Ala Thr Pro 
465                 470                 475                 480 


Pro Gln Ser Leu Leu Glu Lys Val Ser Lys Lys Lys Thr Pro Lys Thr 
                485                 490                 495     


Val Lys Met Pro Lys Pro Ser Lys Ile Pro Lys Pro Pro Lys Pro Pro 
            500                 505                 510         


Lys Pro Pro Arg Pro Pro Lys Thr Leu Lys Leu Lys Asp Gly Gly Lys 
        515                 520                 525             


Lys Lys Gly Lys Lys Ser Arg Glu Ser Ala Ser Pro Thr Ile Pro Asn 
    530                 535                 540                 


Leu Asp Leu Leu Glu Ala His Thr Lys Glu Ala Leu Thr Lys Met Glu 
545                 550                 555                 560 


Pro Pro Lys Lys Gly Lys Ala Thr Lys Ser Val Leu Ser Val Pro Asn 
                565                 570                 575     


Lys Asp Val Val His Met Gln Asn Asp Val Glu Arg Leu Glu Ile Arg 
            580                 585                 590         


Glu Gln Thr Lys Ser Lys Ser Glu Ala Lys Trp Lys Tyr Lys Asn Ser 
        595                 600                 605             


Lys Pro Asp Ser Leu Leu Lys Met Glu Glu Glu Gln Lys Leu Glu Lys 
    610                 615                 620                 


Ser Pro Leu Ala Gly Asn Lys Asp Asn Lys Phe Ser Phe Ser Phe Ser 
625                 630                 635                 640 


Asn Lys Lys Leu Leu Gly Ser Lys Ala Leu Arg Pro Pro Thr Ser Pro 
                645                 650                 655     


Gly Val Phe Gly Ala Leu Gln Asn Phe Lys Glu Asp Lys Pro Lys Pro 
            660                 665                 670         


Val Arg Asp Glu Tyr Glu Tyr Val Ser Asp Asp Gly Glu Leu Lys Ile 
        675                 680                 685             


Asp Glu Phe Pro Ile Arg Arg Lys Lys Asn Ala Pro Lys Arg Asp Leu 
    690                 695                 700                 


Ser Phe Leu Leu Asp Lys Lys Ala Val Leu Pro Thr Pro Val Thr Lys 
705                 710                 715                 720 


Pro Lys Leu Asp Ser Ala Ala Tyr Lys Ser Asp Asp Ser Ser Asp Glu 
                725                 730                 735     


Gly Ser Leu His Ile Asp Thr Asp Thr Lys Pro Gly Arg Asn Ala Arg 
            740                 745                 750         


Val Lys Lys Glu Ser Gly Ser Ser Ala Ala Gly Ile Leu Asp Leu Leu 
        755                 760                 765             


Gln Ala Ser Glu Glu Val Gly Ala Leu Glu Tyr Asn Pro Ser Ser Gln 
    770                 775                 780                 


Pro Pro Ala Ser Pro Ser Thr Gln Glu Ala Ile Gln Gly Met Leu Ser 
785                 790                 795                 800 


Met Ala Asn Leu Gln Ala Ser Asp Ser Cys Leu Gln Thr Thr Trp Gly 
                805                 810                 815     


Ala Gly Gln Ala Lys Gly Ser Ser Leu Ala Ala His Gly Ala Arg Lys 
            820                 825                 830         


Asn Gly Gly Gly Ser Gly Lys Ser Ala Gly Lys Arg Leu Leu Lys Arg 
        835                 840                 845             


Ala Ala Lys Asn Ser Val Asp Leu Asp Asp Tyr Glu Glu Glu Gln Asp 
    850                 855                 860                 


His Leu Asp Ala Cys Phe Lys Asp Ser Asp Tyr Val Tyr Pro Ser Leu 
865                 870                 875                 880 


Glu Ser Asp Glu Asp Asn Pro Ile Phe Lys Ser Arg Ser Lys Lys Arg 
                885                 890                 895     


Lys Gly Ser Asp Asp Ala Pro Tyr Ser Pro Thr Ala Arg Val Gly Pro 
            900                 905                 910         


Ser Val Pro Arg Gln Asp Arg Pro Val Arg Glu Gly Thr Arg Val Ala 
        915                 920                 925             


Ser Ile Glu Thr Gly Leu Ala Ala Ala Ala Ala Lys Leu Ser Gln Gln 
    930                 935                 940                 


Glu Glu Gln Lys Ser Lys Lys Lys Lys Ser Ala Lys Arg Lys Leu Thr 
945                 950                 955                 960 


Pro Asn Thr Thr Ser Pro Ser Thr Ser Thr Ser Ile Ser Ala Gly Thr 
                965                 970                 975     


Thr Ser Thr Ser Thr Thr Pro Ala Ser Thr Thr Pro Ala Ser Thr Thr 
            980                 985                 990         


Pro Ala Ser Thr Ser Thr Ala Ser  Ser Gln Ala Ser Gln  Glu Gly Ser 
        995                 1000                 1005             


Ser Pro  Glu Pro Pro Pro Glu  Ser His Ser Ser Ser  Leu Ala Asp 
    1010                 1015                 1020             


His Glu  Tyr Thr Ala Ala Gly  Thr Phe Thr Gly Ala  Gln Ala Gly 
    1025                 1030                 1035             


Arg Thr  Ser Gln Pro Met Ala  Pro Gly Val Phe Leu  Thr Gln Arg 
    1040                 1045                 1050             


Arg Pro  Ser Ala Ser Ser Pro  Asn Asn Asn Thr Ala  Ala Lys Gly 
    1055                 1060                 1065             


Lys Arg  Thr Lys Lys Gly Met  Ala Thr Ala Lys Gln  Arg Leu Gly 
    1070                 1075                 1080             


Lys Ile  Leu Lys Ile His Arg  Asn Gly Lys Leu Leu  Leu 
    1085                 1090                 1095     


<210>  847
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  847

Met Thr Lys His Pro Pro Asn Arg Arg Gly Ile Ser Phe Glu Val Gly 
1               5                   10                  15      


Ala Gln Leu Glu Ala Arg Asp Arg Leu Lys Asn Trp Tyr Pro Ala His 
            20                  25                  30          


Ile Glu Asp Ile Asp Tyr Glu Glu Gly Lys Val Leu Ile His Phe Lys 
        35                  40                  45              


Arg Trp Asn His Arg Tyr Asp Glu Trp Phe Cys Trp Asp Ser Pro Tyr 
    50                  55                  60                  


Leu Arg Pro Leu Glu Lys Ile Gln Leu Arg Lys Glu Gly Leu His Glu 
65                  70                  75                  80  


Glu Asp Gly Ser Ser Glu Phe Gln Ile Asn Glu Gln Val Leu Ala Cys 
                85                  90                  95      


Trp Ser Asp Cys Arg Phe Tyr Pro Ala Lys Val Thr Ala Val Asn Lys 
            100                 105                 110         


Asp Gly Thr Tyr Thr Val Lys Phe Tyr Asp Gly Val Val Gln Thr Val 
        115                 120                 125             


Lys His Ile His Val Lys Ala Phe Ser Lys Asp Gln Asn Ile Val Gly 
    130                 135                 140                 


Asn Ala Arg Pro Lys Glu Thr Asp His Lys Ser Leu Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Lys Arg Glu Lys Phe Lys Glu Gln Arg Lys Ala Thr Val Asn Val 
                165                 170                 175     


Lys Lys Asp Lys Glu Asp Lys Pro Leu Lys Thr Glu Lys Arg Pro Lys 
            180                 185                 190         


Gln Pro Asp Lys Glu Gly Lys Leu Ile Cys Ser Glu Lys Gly Lys Val 
        195                 200                 205             


Ser Glu Lys Ser Leu Pro Lys Asn Glu Lys Glu Asp Lys Glu Asn Ile 
    210                 215                 220                 


Ser Glu Asn Asp Arg Glu Tyr Ser Gly Asp Ala Gln Val Asp Lys Lys 
225                 230                 235                 240 


Pro Glu Asn Asp Ile Val Lys Ser Pro Gln Glu Asn Leu Arg Glu Pro 
                245                 250                 255     


Lys Arg Lys Arg Gly Arg Pro Pro Ser Ile Ala Pro Thr Ala Val Asp 
            260                 265                 270         


Ser Asn Ser Gln Thr Leu Gln Pro Ile Thr Leu Glu Leu Arg Arg Arg 
        275                 280                 285             


Lys Ile Ser Lys Gly Cys Glu Val Pro Leu Lys Arg Pro Arg Leu Asp 
    290                 295                 300                 


Lys Asn Ser Ser Gln Glu Lys Ser Lys Asn Tyr Ser Glu Asn Thr Asp 
305                 310                 315                 320 


Lys Asp Leu Ser Arg Arg Arg Ser Ser Arg Leu Ser Thr Asn Gly Thr 
                325                 330                 335     


His Glu Ile Leu Asp Pro Asp Leu Val Val Ser Asp Leu Val Asp Thr 
            340                 345                 350         


Asp Pro Leu Gln Asp Thr Leu Ser Ser Thr Lys Glu Ser Glu Glu Gly 
        355                 360                 365             


Gln Leu Lys Ser Ala Leu Glu Ala Gly Gln Val Ser Ser Ala Leu Thr 
    370                 375                 380                 


Cys His Ser Phe Gly Asp Gly Ser Gly Ala Ala Gly Leu Glu Leu Asn 
385                 390                 395                 400 


Cys Pro Ser Met Gly Glu Asn Thr Met Lys Thr Glu Pro Thr Ser Pro 
                405                 410                 415     


Leu Val Glu Leu Gln Glu Ile Ser Thr Val Glu Val Thr Asn Thr Phe 
            420                 425                 430         


Lys Lys Thr Asp Asp Phe Gly Ser Ser Asn Ala Pro Ala Val Asp Leu 
        435                 440                 445             


Asp His Lys Phe Arg Cys Lys Val Val Asp Cys Leu Lys Phe Phe Arg 
    450                 455                 460                 


Lys Ala Lys Leu Leu His Tyr His Met Lys Tyr Phe His Gly Met Glu 
465                 470                 475                 480 


Lys Ser Leu Glu Pro Glu Glu Ser Pro Gly Lys Arg His Val Gln Thr 
                485                 490                 495     


Arg Gly Pro Ser Ala Ser Asp Lys Pro Ser Gln Glu Thr Leu Thr Arg 
            500                 505                 510         


Lys Arg Val Ser Ala Ser Ser Pro Thr Thr Lys Asp Lys Glu Lys Asn 
        515                 520                 525             


Lys Glu Lys Lys Phe Lys Glu Phe Val Arg Val Lys Pro Lys Lys Lys 
    530                 535                 540                 


Lys Lys Lys Lys Lys Lys Thr Lys Pro Glu Cys Pro Cys Ser Glu Glu 
545                 550                 555                 560 


Ile Ser Asp Thr Ser Gln Glu Pro Ser Pro Pro Lys Ala Phe Ala Val 
                565                 570                 575     


Thr Arg Cys Gly Ser Ser His Lys Pro Gly Val His Met Ser Pro Gln 
            580                 585                 590         


Leu His Gly Pro Glu Ser Gly His His Lys Gly Lys Val Lys Ala Leu 
        595                 600                 605             


Glu Glu Asp Asn Leu Ser Glu Ser Ser Ser Glu Ser Phe Leu Trp Ser 
    610                 615                 620                 


Asp Asp Glu Tyr Gly Gln Asp Val Asp Val Thr Thr Asn Pro Asp Glu 
625                 630                 635                 640 


Glu Leu Asp Gly Asp Asp Arg Tyr Asp Phe Glu Val Val Arg Cys Ile 
                645                 650                 655     


Cys Glu Val Gln Glu Glu Asn Asp Phe Met Ile Gln Cys Glu Glu Cys 
            660                 665                 670         


Gln Cys Trp Gln His Gly Val Cys Met Gly Leu Leu Glu Glu Asn Val 
        675                 680                 685             


Pro Glu Lys Tyr Thr Cys Tyr Val Cys Gln Asp Pro Pro Gly Gln Arg 
    690                 695                 700                 


Pro Gly Phe Lys Tyr Trp Tyr Asp Lys Glu Trp Leu Ser Arg Gly His 
705                 710                 715                 720 


Met His Gly Leu Ala Phe Leu Glu Glu Asn Tyr Ser His Gln Asn Ala 
                725                 730                 735     


Lys Lys Ile Val Ala Thr His Gln Leu Leu Gly Asp Val Gln Arg Val 
            740                 745                 750         


Ile Glu Val Leu His Gly Leu Gln Leu Lys Met Ser Ile Leu Gln Ser 
        755                 760                 765             


Arg Glu His Pro Asp Leu Pro Leu Trp Cys Gln Pro Trp Lys Gln His 
    770                 775                 780                 


Ser Gly Glu Gly Arg Ser His Phe Arg Asn Ile Pro Val Thr Asp Thr 
785                 790                 795                 800 


Arg Ser Lys Glu Glu Ala Pro Ser Tyr Arg Thr Leu Asn Gly Ala Val 
                805                 810                 815     


Glu Lys Pro Arg Pro Leu Ala Leu Pro Leu Pro Arg Ser Val Glu Glu 
            820                 825                 830         


Ser Tyr Ile Thr Ser Glu His Cys Tyr Gln Lys Pro Arg Ala Tyr Tyr 
        835                 840                 845             


Pro Ala Val Glu Gln Lys Leu Val Val Glu Thr Arg Gly Ser Ala Leu 
    850                 855                 860                 


Asp Asp Ala Val Asn Pro Leu His Glu Asn Gly Asp Asp Ser Leu Ser 
865                 870                 875                 880 


Pro Arg Leu Gly Trp Pro Leu Asp Gln Asp Arg Ser Lys Gly Asp Ser 
                885                 890                 895     


Asp Pro Lys Pro Gly Ser Pro Lys Val Lys Glu Tyr Val Ser Lys Lys 
            900                 905                 910         


Ala Leu Pro Glu Glu Ala Pro Ala Arg Lys Leu Leu Asp Arg Gly Gly 
        915                 920                 925             


Glu Gly Leu Leu Ser Ser Gln His Gln Trp Gln Phe Asn Leu Leu Thr 
    930                 935                 940                 


His Val Glu Ser Leu Gln Asp Glu Val Thr His Arg Met Asp Ser Ile 
945                 950                 955                 960 


Glu Lys Glu Leu Asp Val Leu Glu Ser Trp Leu Asp Tyr Thr Gly Glu 
                965                 970                 975     


Leu Glu Pro Pro Glu Pro Leu Ala Arg Leu Pro Gln Leu Lys His Cys 
            980                 985                 990         


Ile Lys Gln Leu Leu Met Asp Leu  Gly Lys Val Gln Gln  Ile Ala Leu 
        995                 1000                 1005             


Cys Cys  Ser Thr 
    1010         


<210>  848
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  848

Met Ser Lys Lys Pro Pro Asn Arg Pro Gly Ile Thr Phe Glu Ile Gly 
1               5                   10                  15      


Ala Arg Leu Glu Ala Leu Asp Tyr Leu Gln Lys Trp Tyr Pro Ser Arg 
            20                  25                  30          


Ile Glu Lys Ile Asp Tyr Glu Glu Gly Lys Met Leu Val His Phe Glu 
        35                  40                  45              


Arg Trp Ser His Arg Tyr Asp Glu Trp Ile Tyr Trp Asp Ser Asn Arg 
    50                  55                  60                  


Leu Arg Pro Leu Glu Arg Pro Ala Leu Arg Lys Glu Gly Leu Lys Asp 
65                  70                  75                  80  


Glu Glu Asp Phe Phe Asp Phe Lys Ala Gly Glu Glu Val Leu Ala Arg 
                85                  90                  95      


Trp Thr Asp Cys Arg Tyr Tyr Pro Ala Lys Ile Glu Ala Ile Asn Lys 
            100                 105                 110         


Glu Gly Thr Phe Thr Val Gln Phe Tyr Asp Gly Val Ile Arg Cys Leu 
        115                 120                 125             


Lys Arg Met His Ile Lys Ala Met Pro Glu Asp Ala Lys Gly Gln Val 
    130                 135                 140                 


Lys Ser Gln His Pro Leu Ser Trp Cys Cys Pro Ile Asp Pro Ala Gly 
145                 150                 155                 160 


Ser Cys Asn Gln Ser Met Gly Ser Glu Asp Trp Ile Ala Leu Val Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Lys Asn Lys Thr Gly Ser Lys Pro Arg 
            180                 185                 190         


Thr Ser Ala Asn Ser Asn Lys Asp Lys Asp Lys Asp Glu Arg Lys Trp 
        195                 200                 205             


Phe Lys Val Pro Ser Lys Lys Glu Glu Thr Ser Thr Cys Ile Ala Thr 
    210                 215                 220                 


Pro Asp Val Glu Lys Lys Glu Asp Leu Pro Thr Ser Ser Glu Thr Phe 
225                 230                 235                 240 


Gly Leu His Val Glu Asn Val Pro Lys Met Val Phe Pro Gln Pro Glu 
                245                 250                 255     


Ser Thr Leu Ser Asn Lys Arg Lys Asn Asn Gln Gly Asn Ser Phe Gln 
            260                 265                 270         


Ala Lys Arg Ala Arg Leu Asn Lys Ile Thr Gly Leu Leu Ala Ser Lys 
        275                 280                 285             


Ala Val Gly Val Asp Gly Ala Glu Lys Lys Glu Asp Tyr Asn Glu Thr 
    290                 295                 300                 


Ala Pro Met Leu Glu Gln Ala Ile Ser Pro Lys Pro Gln Ser Gln Lys 
305                 310                 315                 320 


Lys Asn Glu Ala Asp Ile Ser Ser Ser Ala Asn Thr Gln Lys Pro Ala 
                325                 330                 335     


Leu Leu Ser Ser Thr Leu Ser Ser Gly Lys Ala Arg Ser Lys Lys Cys 
            340                 345                 350         


Lys His Glu Ser Gly Asp Ser Ser Gly Cys Ile Lys Pro Pro Lys Ser 
        355                 360                 365             


Pro Leu Ser Pro Glu Leu Ile Gln Val Glu Asp Leu Thr Leu Val Ser 
    370                 375                 380                 


Gln Leu Ser Ser Ser Val Ile Asn Lys Thr Ser Pro Pro Gln Pro Val 
385                 390                 395                 400 


Asn Pro Pro Arg Pro Phe Lys His Ser Glu Arg Arg Arg Arg Ser Gln 
                405                 410                 415     


Arg Leu Ala Thr Leu Pro Met Pro Asp Asp Ser Val Glu Lys Val Ser 
            420                 425                 430         


Ser Pro Ser Pro Ala Thr Asp Gly Lys Val Phe Ser Ile Ser Ser Gln 
        435                 440                 445             


Asn Gln Gln Glu Ser Ser Val Pro Glu Val Pro Asp Val Ala His Leu 
    450                 455                 460                 


Pro Leu Glu Lys Leu Gly Pro Cys Leu Pro Leu Asp Leu Ser Arg Gly 
465                 470                 475                 480 


Ser Glu Val Thr Ala Pro Val Ala Ser Asp Ser Ser Tyr Arg Asn Glu 
                485                 490                 495     


Cys Pro Arg Ala Glu Lys Glu Asp Thr Gln Met Leu Pro Asn Pro Ser 
            500                 505                 510         


Ser Lys Ala Ile Ala Asp Gly Arg Gly Ala Pro Ala Ala Ala Gly Ile 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Val Lys Leu Glu Asp Lys Ser Ser Thr Ala 
    530                 535                 540                 


Phe Gly Lys Arg Lys Glu Lys Asp Lys Glu Arg Arg Glu Lys Arg Asp 
545                 550                 555                 560 


Lys Asp His Tyr Arg Pro Lys Gln Lys Lys Lys Lys Lys Lys Lys Lys 
                565                 570                 575     


Lys Ser Lys Gln His Asp Tyr Ser Asp Tyr Glu Asp Ser Ser Leu Glu 
            580                 585                 590         


Phe Leu Glu Arg Cys Ser Ser Pro Leu Thr Arg Ser Ser Gly Ser Ser 
        595                 600                 605             


Leu Ala Ser Arg Ser Met Phe Thr Glu Lys Thr Thr Thr Tyr Gln Tyr 
    610                 615                 620                 


Pro Arg Ala Ile Leu Ser Val Asp Leu Ser Gly Glu Asn Leu Ser Asp 
625                 630                 635                 640 


Val Asp Phe Leu Asp Asp Ser Ser Thr Glu Ser Leu Leu Leu Ser Gly 
                645                 650                 655     


Asp Glu Tyr Asn Gln Asp Phe Asp Ser Thr Asn Phe Glu Glu Ser Gln 
            660                 665                 670         


Asp Glu Asp Asp Ala Leu Asn Glu Ile Val Arg Cys Ile Cys Glu Met 
        675                 680                 685             


Asp Glu Glu Asn Gly Phe Met Ile Gln Cys Glu Glu Cys Leu Cys Trp 
    690                 695                 700                 


Gln His Ser Val Cys Met Gly Leu Leu Glu Glu Ser Ile Pro Glu Gln 
705                 710                 715                 720 


Tyr Ile Cys Tyr Ile Cys Arg Asp Pro Pro Gly Gln Arg Trp Ser Ala 
                725                 730                 735     


Lys Tyr Arg Tyr Asp Lys Glu Trp Leu Asn Asn Gly Arg Met Cys Gly 
            740                 745                 750         


Leu Ser Phe Phe Lys Glu Asn Tyr Ser His Leu Asn Ala Lys Lys Ile 
        755                 760                 765             


Val Ser Thr His His Leu Leu Ala Asp Val Tyr Gly Val Thr Glu Val 
    770                 775                 780                 


Leu His Gly Leu Gln Leu Lys Ile Gly Ile Leu Lys Asn Lys His His 
785                 790                 795                 800 


Pro Asp Leu His Leu Trp Ala Cys Ser Gly Lys Arg Lys Asp Gln Asp 
                805                 810                 815     


Gln Ile Ile Ala Gly Val Glu Lys Lys Ile Ala Gln Asp Thr Val Asn 
            820                 825                 830         


Arg Glu Glu Lys Lys Tyr Val Gln Asn His Lys Glu Pro Pro Arg Leu 
        835                 840                 845             


Pro Leu Lys Met Glu Gly Thr Tyr Ile Thr Ser Glu His Ser Tyr Gln 
    850                 855                 860                 


Lys Pro Gln Ser Phe Gly Gln Asp Cys Lys Ser Leu Ala Asp Pro Gly 
865                 870                 875                 880 


Ser Ser Asp Asp Asp Asp Val Ser Ser Leu Glu Glu Glu Gln Glu Phe 
                885                 890                 895     


His Met Arg Ser Lys Asn Ser Leu Gln Tyr Ser Ala Lys Glu His Gly 
            900                 905                 910         


Met Pro Glu Lys Asn Pro Ala Glu Gly Asn Thr Val Phe Val Tyr Asn 
        915                 920                 925             


Asp Lys Lys Gly Thr Glu Asp Pro Gly Asp Ser His Leu Gln Trp Gln 
    930                 935                 940                 


Leu Asn Leu Leu Thr His Ile Glu Asn Val Gln Asn Glu Val Thr Ser 
945                 950                 955                 960 


Arg Met Asp Leu Ile Glu Lys Glu Val Asp Val Leu Glu Ser Trp Leu 
                965                 970                 975     


Asp Phe Thr Gly Glu Leu Glu Pro Pro Asp Pro Leu Ala Arg Leu Pro 
            980                 985                 990         


Gln Leu Lys Arg His Ile Lys Gln  Leu Leu Ile Asp Met  Gly Lys Val 
        995                 1000                 1005             


Gln Gln  Ile Ala Thr Leu Cys  Ser Val 
    1010                 1015         


<210>  849
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  849

Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 
1               5                   10                  15      


Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 
            20                  25                  30          


Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 
        35                  40                  45              


Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 
    50                  55                  60                  


Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 
65                  70                  75                  80  


Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 
                85                  90                  95      


Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 
            100                 105                 110         


Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 
        115                 120                 125             


Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 
    130                 135                 140                 


Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 
145                 150                 155                 160 


Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 
                165                 170                 175     


Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 
            180                 185                 190         


Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 
        195                 200                 205             


Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 
    210                 215                 220                 


Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 
225                 230                 235                 240 


Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 
                245                 250                 255     


Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 
            260                 265                 270         


Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 
        275                 280                 285             


Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 
    290                 295                 300                 


Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 
305                 310                 315                 320 


Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 
                325                 330                 335     


Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 
            340                 345                 350         


Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 
        355                 360                 365             


Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 
    370                 375                 380                 


Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 
385                 390                 395                 400 


Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 
                405                 410                 415     


Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 
            420                 425                 430         


Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 
        435                 440                 445             


Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 
    450                 455                 460                 


Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 
465                 470                 475                 480 


Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 
                485                 490                 495     


Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 
            500                 505                 510         


Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 
        515                 520                 525             


Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 
    530                 535                 540                 


Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 
545                 550                 555                 560 


Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 
                565                 570                 575     


Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 
            580                 585                 590         


Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 
        595                 600                 605             


Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 
    610                 615                 620                 


Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 
625                 630                 635                 640 


Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 
                645                 650                 655     


Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 
            660                 665                 670         


Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 
        675                 680                 685             


Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 
    690                 695                 700                 


Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 
705                 710                 715                 720 


Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 
                725                 730                 735     


Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 
            740                 745                 750         


Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 
        755                 760                 765             


Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 
    770                 775                 780                 


Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 
785                 790                 795                 800 


Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 
                805                 810                 815     


Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 
            820                 825                 830         


Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 
        835                 840                 845             


Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 
    850                 855                 860                 


Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 
865                 870                 875                 880 


Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 
                885                 890                 895     


Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 
            900                 905                 910         


Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 
        915                 920                 925             


Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 
    930                 935                 940                 


Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 
945                 950                 955                 960 


Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 
                965                 970                 975     


Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 
            980                 985                 990         


Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 
        995                 1000                 1005             


His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 
    1010                 1015                 1020             


Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 
    1025                 1030                 1035             


Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 
    1040                 1045                 1050             


Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 
    1055                 1060                 1065             


Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 
    1070                 1075                 1080             


Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 
    1085                 1090                 1095             


Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 
    1100                 1105                 1110             


Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 
    1115                 1120                 1125             


Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 
    1130                 1135                 1140             


Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 
    1145                 1150                 1155             


Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 
    1160                 1165                 1170             


Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 
    1175                 1180                 1185             


Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 
    1190                 1195                 1200             


Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 
    1205                 1210                 1215             


Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 
    1220                 1225                 1230             


Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 
    1235                 1240                 1245             


Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 
    1250                 1255                 1260             


Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 
    1265                 1270                 1275             


Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 
    1280                 1285                 1290             


Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 
    1295                 1300                 1305             


Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 
    1310                 1315                 1320             


His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 
    1325                 1330                 1335             


Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 
    1340                 1345                 1350             


Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 
    1355                 1360                 1365             


Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 
    1370                 1375                 1380             


Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 
    1385                 1390                 1395             


Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 
    1400                 1405                 1410             


Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 
    1415                 1420                 1425             


Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 
    1430                 1435                 1440             


Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 
    1445                 1450                 1455             


Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 
    1460                 1465                 1470             


Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 
    1475                 1480                 1485             


Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 
    1490                 1495                 1500             


Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 
    1505                 1510                 1515             


Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 
    1535                 1540                 1545             


Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 
    1550                 1555                 1560             


Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 
    1565                 1570                 1575             


Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 
    1580                 1585                 1590             


Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 
    1595                 1600                 1605             


Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 
    1610                 1615                 1620             


Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 
    1625                 1630                 1635             


Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 
    1640                 1645                 1650             


Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 
    1655                 1660                 1665             


Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 
    1670                 1675                 1680             


Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 
    1685                 1690                 1695             


Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 
    1700                 1705                 1710             


Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 
    1715                 1720                 1725             


Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 
    1730                 1735                 1740             


Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 
    1745                 1750                 1755             


Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 
    1760                 1765                 1770             


Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 
    1775                 1780                 1785             


Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 
    1790                 1795                 1800             


Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 
    1805                 1810                 1815             


Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 
    1820                 1825                 1830             


His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 
    1835                 1840                 1845             


Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 
    1850                 1855                 1860             


Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 
    1865                 1870                 1875             


Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 
    1880                 1885                 1890             


Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 
    1895                 1900                 1905             


Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 
    1910                 1915                 1920             


Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 
    1925                 1930                 1935             


Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 
    1940                 1945                 1950             


Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 
    1955                 1960                 1965             


Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 
    1970                 1975                 1980             


Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 
    1985                 1990                 1995             


Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 
    2000                 2005                 2010             


Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 
    2015                 2020                 2025             


Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 
    2030                 2035                 


<210>  850
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  850

Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     


<210>  851
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  851

Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu 
1               5                   10                  15      


Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu 
            20                  25                  30          


Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn 
        35                  40                  45              


Trp Leu Asp Ala Gln Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala 
    50                  55                  60                  


Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Arg Gly Pro 
65                  70                  75                  80  


Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys 
                85                  90                  95      


Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gln Ala Leu Pro Ala Phe 
            100                 105                 110         


Thr Thr Glu Ile Gln Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val 
        115                 120                 125             


Gln Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala 
    130                 135                 140                 


Ala Val Gln Pro Val Ile Gly Ile Ser Gln Arg Val Arg Met Asn Ser 
145                 150                 155                 160 


Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Tyr Val Leu Gly Ile Thr 
                165                 170                 175     


Met Met Val Ile Ile Ile Ala Ile Gly Ala Gly Ile Ile Leu Gly Tyr 
            180                 185                 190         


Ser Tyr Lys Arg Gly Lys Asp Leu Lys Glu Gln His Asp Gln Lys Val 
        195                 200                 205             


Cys Glu Arg Glu Met Gln Arg Ile Thr Leu Pro Leu Ser Ala Phe Thr 
    210                 215                 220                 


Asn Pro Thr Cys Glu Ile Val Asp Glu Lys Thr Val Val Val His Thr 
225                 230                 235                 240 


Ser Gln Thr Pro Val Asp Pro Gln Glu Gly Thr Thr Pro Leu Met Gly 
                245                 250                 255     


Gln Ala Gly Thr Pro Gly Ala 
            260             


<210>  852
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  852

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly 
            20                  25                  30          


Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp 
        35                  40                  45              


Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro 
    50                  55                  60                  


Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  


Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys 
                85                  90                  95      


Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         


Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile 
        115                 120                 125             


Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp 
    130                 135                 140                 


Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln 
145                 150                 155                 160 


Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     


Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro 
            180                 185                 190         


Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala 
        195                 200                 205             


Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile 
    210                 215                 220                 


Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu 
225                 230                 235                 240 


Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val 
                245                 250                 255     


Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro 
            260                 265                 270         


Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu 
        275                 280                 285             


Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His 
    290                 295                 300                 


Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn 
305                 310                 315                 320 


Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro 
                325                 330                 335     


Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His 
            340                 345                 350         


Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile 
        355                 360                 365             


Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp 
    370                 375                 380                 


Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe 
385                 390                 395                 400 


Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro 
                405                 410                 415     


Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser 
            420                 425                 430         


Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly 
        435                 440                 445             


Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg 
    450                 455                 460                 


Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro 
465                 470                 475                 480 


Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys 
                485                 490                 495     


Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp 
            500                 505                 510         


Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val 
        515                 520                 525             


Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu 
    530                 535                 540                 


Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala 
545                 550                 555                 560 


Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser 
                565                 570                 575     


Trp Arg Ala Ala Leu 
            580     


<210>  853
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  853

Met Met Cys Gln Ser Glu Ala Arg Gln Gly Pro Glu Leu Arg Ala Ala 
1               5                   10                  15      


Lys Trp Leu His Phe Pro Gln Leu Ala Leu Arg Arg Arg Leu Gly Gln 
            20                  25                  30          


Leu Ser Cys Met Ser Arg Pro Ala Leu Lys Leu Arg Ser Trp Pro Leu 
        35                  40                  45              


Thr Val Leu Tyr Tyr Leu Leu Pro Phe Gly Ala Leu Arg Pro Leu Ser 
    50                  55                  60                  


Arg Val Gly Trp Arg Pro Val Ser Arg Val Ala Leu Tyr Lys Ser Val 
65                  70                  75                  80  


Pro Thr Arg Leu Leu Ser Arg Ala Trp Gly Arg Leu Asn Gln Val Glu 
                85                  90                  95      


Leu Pro His Trp Leu Arg Arg Pro Val Tyr Ser Leu Tyr Ile Trp Thr 
            100                 105                 110         


Phe Gly Val Asn Met Lys Glu Ala Ala Val Glu Asp Leu His His Tyr 
        115                 120                 125             


Arg Asn Leu Ser Glu Phe Phe Arg Arg Lys Leu Lys Pro Gln Ala Arg 
    130                 135                 140                 


Pro Val Cys Gly Leu His Ser Val Ile Ser Pro Ser Asp Gly Arg Ile 
145                 150                 155                 160 


Leu Asn Phe Gly Gln Val Lys Asn Cys Glu Val Glu Gln Val Lys Gly 
                165                 170                 175     


Val Thr Tyr Ser Leu Glu Ser Phe Leu Gly Pro Arg Met Cys Thr Glu 
            180                 185                 190         


Asp Leu Pro Phe Pro Pro Ala Ala Ser Cys Asp Ser Phe Lys Asn Gln 
        195                 200                 205             


Leu Val Thr Arg Glu Gly Asn Glu Leu Tyr His Cys Val Ile Tyr Leu 
    210                 215                 220                 


Ala Pro Gly Asp Tyr His Cys Phe His Ser Pro Thr Asp Trp Thr Val 
225                 230                 235                 240 


Ser His Arg Arg His Phe Pro Gly Ser Leu Met Ser Val Asn Pro Gly 
                245                 250                 255     


Met Ala Arg Trp Ile Lys Glu Leu Phe Cys His Asn Glu Arg Val Val 
            260                 265                 270         


Leu Thr Gly Asp Trp Lys His Gly Phe Phe Ser Leu Thr Ala Val Gly 
        275                 280                 285             


Ala Thr Asn Val Gly Ser Ile Arg Ile Tyr Phe Asp Arg Asp Leu His 
    290                 295                 300                 


Thr Asn Ser Pro Arg His Ser Lys Gly Ser Tyr Asn Asp Phe Ser Phe 
305                 310                 315                 320 


Val Thr His Thr Asn Arg Glu Gly Val Pro Met Arg Lys Gly Glu His 
                325                 330                 335     


Leu Gly Glu Phe Asn Leu Gly Ser Thr Ile Val Leu Ile Phe Glu Ala 
            340                 345                 350         


Pro Lys Asp Phe Asn Phe Gln Leu Lys Thr Gly Gln Lys Ile Arg Phe 
        355                 360                 365             


Gly Glu Ala Leu Gly Ser Leu 
    370                 375 


<210>  854
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  854

Met Val Leu Leu Lys Glu Tyr Arg Val Ile Leu Pro Val Ser Val Asp 
1               5                   10                  15      


Glu Tyr Gln Val Gly Gln Leu Tyr Ser Val Ala Glu Ala Ser Lys Asn 
            20                  25                  30          


Glu Thr Gly Gly Gly Glu Gly Val Glu Val Leu Val Asn Glu Pro Tyr 
        35                  40                  45              


Glu Lys Asp Gly Glu Lys Gly Gln Tyr Thr His Lys Ile Tyr His Leu 
    50                  55                  60                  


Gln Ser Lys Val Pro Thr Phe Val Arg Met Leu Ala Pro Glu Gly Ala 
65                  70                  75                  80  


Leu Asn Ile His Glu Lys Ala Trp Asn Ala Tyr Pro Tyr Cys Arg Thr 
                85                  90                  95      


Val Ile Thr Asn Glu Tyr Met Lys Glu Asp Phe Leu Ile Lys Ile Glu 
            100                 105                 110         


Thr Trp His Lys Pro Asp Leu Gly Thr Gln Glu Asn Val His Lys Leu 
        115                 120                 125             


Glu Pro Glu Ala Trp Lys His Val Glu Ala Val Tyr Ile Asp Ile Ala 
    130                 135                 140                 


Asp Arg Ser Gln Val Leu Ser Lys Asp Tyr Lys Ala Glu Glu Asp Pro 
145                 150                 155                 160 


Ala Lys Phe Lys Ser Ile Lys Thr Gly Arg Gly Pro Leu Gly Pro Asn 
                165                 170                 175     


Trp Lys Gln Glu Leu Val Asn Gln Lys Asp Cys Pro Tyr Met Cys Ala 
            180                 185                 190         


Tyr Lys Leu Val Thr Val Lys Phe Lys Trp Trp Gly Leu Gln Asn Lys 
        195                 200                 205             


Val Glu Asn Phe Ile His Lys Gln Glu Arg Arg Leu Phe Thr Asn Phe 
    210                 215                 220                 


His Arg Gln Leu Phe Cys Trp Leu Asp Lys Trp Val Asp Leu Thr Met 
225                 230                 235                 240 


Asp Asp Ile Arg Arg Met Glu Glu Glu Thr Lys Arg Gln Leu Asp Glu 
                245                 250                 255     


Met Arg Gln Lys Asp Pro Val Lys Gly Met Thr Ala Asp Asp 
            260                 265                 270 


<210>  855
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  855

Met Met Lys Lys Asn Asn Ser Ala Lys Arg Gly Pro Gln Asp Gly Asn 
1               5                   10                  15      


Gln Gln Pro Ala Pro Pro Glu Lys Val Gly Trp Val Arg Lys Phe Cys 
            20                  25                  30          


Gly Lys Gly Ile Phe Arg Glu Ile Trp Lys Asn Arg Tyr Val Val Leu 
        35                  40                  45              


Lys Gly Asp Gln Leu Tyr Ile Ser Glu Lys Glu Val Lys Asp Glu Lys 
    50                  55                  60                  


Asn Ile Gln Glu Val Phe Asp Leu Ser Asp Tyr Glu Lys Cys Glu Glu 
65                  70                  75                  80  


Leu Arg Lys Ser Lys Ser Arg Ser Lys Lys Asn His Ser Lys Phe Thr 
                85                  90                  95      


Leu Ala His Ser Lys Gln Pro Gly Asn Thr Ala Pro Asn Leu Ile Phe 
            100                 105                 110         


Leu Ala Val Ser Pro Glu Glu Lys Glu Ser Trp Ile Asn Ala Leu Asn 
        115                 120                 125             


Ser Ala Ile Thr Arg Ala Lys Asn Arg Ile Leu Asp Glu Val Thr Val 
    130                 135                 140                 


Glu Glu Asp Ser Tyr Leu Ala His Pro Thr Arg Asp Arg Ala Lys Ile 
145                 150                 155                 160 


Gln His Ser Arg Arg Pro Pro Thr Arg Gly His Leu Met Ala Val Ala 
                165                 170                 175     


Ser Thr Ser Thr Ser Asp Gly Met Leu Thr Leu Asp Leu Ile Gln Glu 
            180                 185                 190         


Glu Asp Pro Ser Pro Glu Glu Pro Thr Ser Cys Ala Glu Ser Phe Arg 
        195                 200                 205             


Val Asp Leu Asp Lys Ser Val Ala Gln Leu Ala Gly Ser Arg Arg Arg 
    210                 215                 220                 


Ala Asp Ser Asp Arg Ile Gln Pro Ser Ala Asp Arg Ala Ser Ser Leu 
225                 230                 235                 240 


Ser Arg Pro Trp Glu Lys Thr Asp Lys Gly Ala Thr Tyr Thr Pro Gln 
                245                 250                 255     


Ala Pro Lys Lys Leu Thr Pro Thr Glu Lys Gly Arg Cys Ala Ser Leu 
            260                 265                 270         


Glu Glu Ile Leu Ser Gln Arg Asp Ala Ala Ser Ala Arg Thr Leu Gln 
        275                 280                 285             


Leu Arg Ala Glu Glu Pro Pro Thr Pro Ala Leu Pro Asn Pro Gly Gln 
    290                 295                 300                 


Leu Ser Arg Ile Gln Asp Leu Val Ala Arg Lys Leu Glu Glu Thr Gln 
305                 310                 315                 320 


Glu Leu Leu Ala Glu Val Gln Gly Leu Gly Asp Gly Lys Arg Lys Ala 
                325                 330                 335     


Lys Asp Pro Pro Arg Ser Pro Pro Asp Ser Glu Ser Glu Gln Leu Leu 
            340                 345                 350         


Leu Glu Thr Glu Arg Leu Leu Gly Glu Ala Ser Ser Asn Trp Ser Gln 
        355                 360                 365             


Ala Lys Arg Val Leu Gln Glu Val Arg Glu Leu Arg Asp Leu Tyr Arg 
    370                 375                 380                 


Gln Met Asp Leu Gln Thr Pro Asp Ser His Leu Arg Gln Thr Thr Pro 
385                 390                 395                 400 


His Ser Gln Tyr Arg Lys Ser Leu Met 
                405                 


<210>  856
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  856

Met Glu Glu Glu Gly Val Lys Glu Ala Gly Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Gln Met Val Asp Lys Ala Gly Trp Ile Lys Lys Ser Ser Gly Gly Leu 
            20                  25                  30          


Leu Gly Phe Trp Lys Asp Arg Tyr Leu Leu Leu Cys Gln Ala Gln Leu 
        35                  40                  45              


Leu Val Tyr Glu Asn Glu Asp Asp Gln Lys Cys Val Glu Thr Val Glu 
    50                  55                  60                  


Leu Gly Ser Tyr Glu Lys Cys Gln Asp Leu Arg Ala Leu Leu Lys Arg 
65                  70                  75                  80  


Lys His Arg Phe Ile Leu Leu Arg Ser Pro Gly Asn Lys Val Ser Asp 
                85                  90                  95      


Ile Lys Phe Gln Ala Pro Thr Gly Glu Glu Lys Glu Ser Trp Ile Lys 
            100                 105                 110         


Ala Leu Asn Glu Gly Ile Asn Arg Gly Lys Asn Lys Ala Phe Asp Glu 
        115                 120                 125             


Val Lys Val Asp Lys Ser Cys Ala Leu Glu His Val Thr Arg Asp Arg 
    130                 135                 140                 


Val Arg Gly Gly Gln Arg Arg Arg Pro Pro Thr Arg Val His Leu Lys 
145                 150                 155                 160 


Glu Val Ala Ser Ala Ala Ser Asp Gly Leu Leu Arg Leu Asp Leu Asp 
                165                 170                 175     


Val Pro Asp Ser Gly Pro Pro Val Phe Ala Pro Ser Asn His Val Ser 
            180                 185                 190         


Glu Ala Gln Pro Arg Glu Thr Pro Arg Pro Leu Met Pro Pro Thr Lys 
        195                 200                 205             


Pro Phe Leu Ala Pro Glu Thr Thr Ser Pro Gly Asp Arg Val Glu Thr 
    210                 215                 220                 


Pro Val Gly Glu Arg Ala Pro Thr Pro Val Ser Ala Ser Ser Glu Val 
225                 230                 235                 240 


Ser Pro Glu Ser Gln Glu Asp Ser Glu Thr Pro Ala Glu Glu Asp Ser 
                245                 250                 255     


Gly Ser Glu Gln Pro Pro Asn Ser Val Leu Pro Asp Lys Leu Lys Val 
            260                 265                 270         


Ser Trp Glu Asn Pro Ser Pro Gln Glu Ala Pro Ala Ala Glu Ser Ala 
        275                 280                 285             


Glu Pro Ser Gln Ala Pro Cys Ser Glu Thr Ser Glu Ala Ala Pro Arg 
    290                 295                 300                 


Glu Gly Gly Lys Pro Pro Thr Pro Pro Pro Lys Ile Leu Ser Glu Lys 
305                 310                 315                 320 


Leu Lys Ala Ser Met Gly Glu Met Gln Ala Ser Gly Pro Pro Ala Pro 
                325                 330                 335     


Gly Thr Val Gln Val Ser Val Asn Gly Met Asp Asp Ser Pro Glu Pro 
            340                 345                 350         


Ala Lys Pro Ser Gln Ala Glu Gly Thr Pro Gly Thr Pro Pro Lys Asp 
        355                 360                 365             


Ala Thr Thr Ser Thr Ala Leu Pro Pro Trp Asp Leu Pro Pro Gln Phe 
    370                 375                 380                 


His Pro Arg Cys Ser Ser Leu Gly Asp Leu Leu Gly Glu Gly Pro Arg 
385                 390                 395                 400 


His Pro Leu Gln Pro Arg Glu Arg Leu Tyr Arg Ala Gln Leu Glu Val 
                405                 410                 415     


Lys Val Ala Ser Glu Gln Thr Glu Lys Leu Leu Asn Lys Val Leu Gly 
            420                 425                 430         


Ser Glu Pro Ala Pro Val Ser Ala Glu Thr Leu Leu Ser Gln Ala Val 
        435                 440                 445             


Glu Gln Leu Arg Gln Ala Thr Gln Val Leu Gln Glu Met Arg Asp Leu 
    450                 455                 460                 


Gly Glu Leu Ser Gln Glu Ala Pro Gly Leu Arg Glu Lys Arg Lys Glu 
465                 470                 475                 480 


Leu Val Thr Leu Tyr Arg Arg Ser Ala Pro 
                485                 490 


<210>  857
<211>  1568
<212>  PRT
<213>  Homo sapiens

<400>  857

Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala 
1               5                   10                  15      


Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly 
            20                  25                  30          


Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala 
        35                  40                  45              


Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys 
    50                  55                  60                  


Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr 
65                  70                  75                  80  


Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro 
                85                  90                  95      


Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr 
            100                 105                 110         


Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr 
        115                 120                 125             


Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg 
    130                 135                 140                 


Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly 
145                 150                 155                 160 


Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr 
                165                 170                 175     


Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser 
            180                 185                 190         


Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys 
        195                 200                 205             


Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys 
    210                 215                 220                 


Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp 
225                 230                 235                 240 


Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly 
                245                 250                 255     


Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu 
            260                 265                 270         


Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro 
        275                 280                 285             


Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp 
    290                 295                 300                 


Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg 
305                 310                 315                 320 


Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile 
                325                 330                 335     


Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser 
            340                 345                 350         


His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser 
        355                 360                 365             


Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val 
    370                 375                 380                 


Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu 
385                 390                 395                 400 


Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile 
                405                 410                 415     


Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp 
            420                 425                 430         


Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg 
        435                 440                 445             


Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys 
    450                 455                 460                 


Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg 
465                 470                 475                 480 


Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp 
                485                 490                 495     


Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile 
            500                 505                 510         


Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser 
        515                 520                 525             


Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu 
    530                 535                 540                 


Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile 
545                 550                 555                 560 


Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe 
                565                 570                 575     


Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys 
            580                 585                 590         


Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp 
        595                 600                 605             


Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro 
    610                 615                 620                 


Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys 
625                 630                 635                 640 


Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn 
                645                 650                 655     


Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val 
            660                 665                 670         


Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr 
        675                 680                 685             


Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp 
    690                 695                 700                 


Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys 
705                 710                 715                 720 


Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln 
                725                 730                 735     


Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala 
            740                 745                 750         


Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly 
        755                 760                 765             


Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn 
    770                 775                 780                 


Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr 
785                 790                 795                 800 


Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser 
                805                 810                 815     


Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr 
            820                 825                 830         


Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly 
        835                 840                 845             


Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln 
    850                 855                 860                 


Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr 
865                 870                 875                 880 


Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile 
                885                 890                 895     


Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile 
            900                 905                 910         


Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys 
        915                 920                 925             


Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr 
    930                 935                 940                 


Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe 
945                 950                 955                 960 


Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys 
                965                 970                 975     


Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile 
            980                 985                 990         


Arg Asp Gly Phe Ala Glu Leu Gln  Met Asp Lys Leu Asp  Val Val Asp 
        995                 1000                 1005             


Ser Phe  Gly Thr Val Pro Phe  Leu Asp Tyr Lys His  Phe Ala Leu 
    1010                 1015                 1020             


Arg Thr  Phe Phe Pro Glu Ser  Gly Gly Phe Thr His  Ile Phe Thr 
    1025                 1030                 1035             


Glu Asp  Met His Asn Arg Asp  Ala Asn Asp Lys Asn  Glu Ser Leu 
    1040                 1045                 1050             


Thr Ala  Leu Asp Ala Leu Ile  Cys Asn Lys Ser Phe  Leu Val Thr 
    1055                 1060                 1065             


Val Ile  His Thr Leu Glu Lys  Gln Lys Asn Phe Ser  Val Lys Asp 
    1070                 1075                 1080             


Arg Cys  Leu Phe Ala Ser Phe  Leu Thr Ile Ala Leu  Gln Thr Lys 
    1085                 1090                 1095             


Leu Val  Tyr Leu Thr Ser Ile  Leu Glu Val Leu Thr  Arg Asp Leu 
    1100                 1105                 1110             


Met Glu  Gln Cys Ser Asn Met  Gln Pro Lys Leu Met  Leu Arg Arg 
    1115                 1120                 1125             


Thr Glu  Ser Val Val Glu Lys  Leu Leu Thr Asn Trp  Met Ser Val 
    1130                 1135                 1140             


Cys Leu  Ser Gly Phe Leu Arg  Glu Thr Val Gly Glu  Pro Phe Tyr 
    1145                 1150                 1155             


Leu Leu  Val Thr Thr Leu Asn  Gln Lys Ile Asn Lys  Gly Pro Val 
    1160                 1165                 1170             


Asp Val  Ile Thr Cys Lys Ala  Leu Tyr Thr Leu Asn  Glu Asp Trp 
    1175                 1180                 1185             


Leu Leu  Trp Gln Val Pro Glu  Phe Ser Thr Val Ala  Leu Asn Val 
    1190                 1195                 1200             


Val Phe  Glu Lys Ile Pro Glu  Asn Glu Ser Ala Asp  Val Cys Arg 
    1205                 1210                 1215             


Asn Ile  Ser Val Asn Val Leu  Asp Cys Asp Thr Ile  Gly Gln Ala 
    1220                 1225                 1230             


Lys Glu  Lys Ile Phe Gln Ala  Phe Leu Ser Lys Asn  Gly Ser Pro 
    1235                 1240                 1245             


Tyr Gly  Leu Gln Leu Asn Glu  Ile Gly Leu Glu Leu  Gln Met Gly 
    1250                 1255                 1260             


Thr Arg  Gln Lys Glu Leu Leu  Asp Ile Asp Ser Ser  Ser Val Ile 
    1265                 1270                 1275             


Leu Glu  Asp Gly Ile Thr Lys  Leu Asn Thr Ile Gly  His Tyr Glu 
    1280                 1285                 1290             


Ile Ser  Asn Gly Ser Thr Ile  Lys Val Phe Lys Lys  Ile Ala Asn 
    1295                 1300                 1305             


Phe Thr  Ser Asp Val Glu Tyr  Ser Asp Asp His Cys  His Leu Ile 
    1310                 1315                 1320             


Leu Pro  Asp Ser Glu Ala Phe  Gln Asp Val Gln Gly  Lys Arg His 
    1325                 1330                 1335             


Arg Gly  Lys His Lys Phe Lys  Val Lys Glu Met Tyr  Leu Thr Lys 
    1340                 1345                 1350             


Leu Leu  Ser Thr Lys Val Ala  Ile His Ser Val Leu  Glu Lys Leu 
    1355                 1360                 1365             


Phe Arg  Ser Ile Trp Ser Leu  Pro Asn Ser Arg Ala  Pro Phe Ala 
    1370                 1375                 1380             


Ile Lys  Tyr Phe Phe Asp Phe  Leu Asp Ala Gln Ala  Glu Asn Lys 
    1385                 1390                 1395             


Lys Ile  Thr Asp Pro Asp Val  Val His Ile Trp Lys  Thr Asn Ser 
    1400                 1405                 1410             


Leu Pro  Leu Arg Phe Trp Val  Asn Ile Leu Lys Asn  Pro Gln Phe 
    1415                 1420                 1425             


Val Phe  Asp Ile Lys Lys Thr  Pro His Ile Asp Gly  Cys Leu Ser 
    1430                 1435                 1440             


Val Ile  Ala Gln Ala Phe Met  Asp Ala Phe Ser Leu  Thr Glu Gln 
    1445                 1450                 1455             


Gln Leu  Gly Lys Glu Ala Pro  Thr Asn Lys Leu Leu  Tyr Ala Lys 
    1460                 1465                 1470             


Asp Ile  Pro Thr Tyr Lys Glu  Glu Val Lys Ser Tyr  Tyr Lys Ala 
    1475                 1480                 1485             


Ile Arg  Asp Leu Pro Pro Leu  Ser Ser Ser Glu Met  Glu Glu Phe 
    1490                 1495                 1500             


Leu Thr  Gln Glu Ser Lys Lys  His Glu Asn Glu Phe  Asn Glu Glu 
    1505                 1510                 1515             


Val Ala  Leu Thr Glu Ile Tyr  Lys Tyr Ile Val Lys  Tyr Phe Asp 
    1520                 1525                 1530             


Glu Ile  Leu Asn Lys Leu Glu  Arg Glu Arg Gly Leu  Glu Glu Ala 
    1535                 1540                 1545             


Gln Lys  Gln Leu Leu His Val  Lys Val Leu Phe Asp  Glu Lys Lys 
    1550                 1555                 1560             


Lys Cys  Lys Trp Met 
    1565             


<210>  858
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  858

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly 
    130                 135                 140                 


Asp Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp 
145                 150                 155                 160 


Ile Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr 
                165                 170                 175     


Val Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp 
            180                 185                 190         


Val Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro 
        195                 200                 205             


Lys Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile 
    210                 215                 220                 


Thr Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln 
225                 230                 235                 240 


Leu Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp 
                245                 250                 255     


Ile Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe 
            260                 265                 270         


Thr Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu 
        275                 280                 285             


Lys Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr 
    290                 295                 300                 


Gly Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe 
305                 310                 315                 320 


Asp Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                325                 330                 335 


<210>  859
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  859

Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg 
1               5                   10                  15      


Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu 
            20                  25                  30          


Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu 
        35                  40                  45              


Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Ile 
    50                  55                  60                  


Thr Arg Leu Gln Arg Trp Cys Arg Ala Lys Gln Met Gly Leu Glu Pro 
65                  70                  75                  80  


Pro Pro Glu Val Trp Gln Val Leu Lys Thr His Pro Gly Asp Pro Arg 
                85                  90                  95      


Phe Gln Cys Ser Leu Trp His Leu Tyr Pro Leu 
            100                 105         


<210>  860
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  860

Met Glu Glu Asp Gln Glu Leu Glu Arg Lys Ile Ser Gly Leu Lys Thr 
1               5                   10                  15      


Ser Met Ala Glu Gly Glu Arg Lys Thr Ala Leu Glu Met Val Gln Ala 
            20                  25                  30          


Ala Gly Thr Asp Arg His Cys Val Thr Phe Val Leu His Glu Glu Asp 
        35                  40                  45              


His Thr Leu Gly Asn Ser Leu Arg Tyr Met Ile Met Lys Asn Pro Glu 
    50                  55                  60                  


Val Glu Phe Cys Gly Tyr Thr Thr Thr His Pro Ser Glu Ser Lys Ile 
65                  70                  75                  80  


Asn Leu Arg Ile Gln Thr Arg Gly Thr Leu Pro Ala Val Glu Pro Phe 
                85                  90                  95      


Gln Arg Gly Leu Asn Glu Leu Met Asn Val Cys Gln His Val Leu Asp 
            100                 105                 110         


Lys Phe Glu Ala Ser Ile Lys Asp Tyr Lys Asp Gln Lys Ala Ser Arg 
        115                 120                 125             


Asn Glu Ser Thr Phe 
    130             


<210>  861
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  861

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser Arg Ser 
        35                  40                  45              


Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys Asp Gly 
    50                  55                  60                  


Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly Asp Lys 
65                  70                  75                  80  


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
                85                  90                  95      


Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys Cys Glu 
            100                 105                 110         


Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys 
        115                 120                 125             


Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala Ile Arg 
    130                 135                 140                 


Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu 
145                 150                 155                 160 


Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys 
                165                 170                 175     


Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met 
            180                 185                 190         


Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr 
        195                 200                 205             


Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys 
    210                 215                 220                 


Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu 
225                 230                 235                 240 


Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr 
                245                 250                 255     


Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser 
            260                 265                 270         


Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
        275                 280                 285             


Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu 
    290                 295                 300                 


Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu 
305                 310                 315                 320 


Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val 
                325                 330                 335     


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile 
            340                 345                 350         


Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn Val Pro 
        355                 360                 365             


Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu Phe His 
    370                 375                 380                 


Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met 
                405                 410                 415     


Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His Pro Leu 
            420                 425                 430         


Leu Gln Glu Ile Tyr Lys Asp Met Tyr 
        435                 440     


<210>  862
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  862

Met Ser Ser Gly Ala Pro Gln Lys Ser Ser Pro Met Ala Ser Gly Ala 
1               5                   10                  15      


Glu Glu Thr Pro Gly Phe Leu Asp Thr Leu Leu Gln Asp Phe Pro Ala 
            20                  25                  30          


Leu Leu Asn Pro Glu Asp Pro Leu Pro Trp Lys Ala Pro Gly Thr Val 
        35                  40                  45              


Leu Ser Gln Glu Glu Val Glu Gly Glu Leu Ala Glu Leu Ala Met Gly 
    50                  55                  60                  


Phe Leu Gly Ser Arg Lys Ala Pro Pro Pro Leu Ala Ala Ala Leu Ala 
65                  70                  75                  80  


His Glu Ala Val Ser Gln Leu Leu Gln Thr Asp Leu Ser Glu Phe Arg 
                85                  90                  95      


Lys Leu Pro Arg Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Glu Glu 
            100                 105                 110         


Glu Lys Ala Pro Val Thr Leu Leu Asp Ala Gln Ser Leu Ala Gln Ser 
        115                 120                 125             


Phe Phe Asn Arg Leu Trp Glu Val Ala Gly Gln Trp Gln Lys Gln Val 
    130                 135                 140                 


Pro Leu Ala Ala Arg Ala Ser Gln Arg Gln Trp Leu Val Ser Ile His 
145                 150                 155                 160 


Ala Ile Arg Asn Thr Arg Arg Lys Met Glu Asp Arg His Val Ser Leu 
                165                 170                 175     


Pro Ser Phe Asn Gln Leu Phe Gly Leu Ser Asp Pro Val Asn Arg Ala 
            180                 185                 190         


Tyr Phe Ala Val Phe Asp Gly His Gly Gly Val Asp Ala Ala Arg Tyr 
        195                 200                 205             


Ala Ala Val His Val His Thr Asn Ala Ala Arg Gln Pro Glu Leu Pro 
    210                 215                 220                 


Thr Asp Pro Glu Gly Ala Leu Arg Glu Ala Phe Arg Arg Thr Asp Gln 
225                 230                 235                 240 


Met Phe Leu Arg Lys Ala Lys Arg Glu Arg Leu Gln Ser Gly Thr Thr 
                245                 250                 255     


Gly Val Cys Ala Leu Ile Ala Gly Ala Thr Leu His Val Ala Trp Leu 
            260                 265                 270         


Gly Asp Ser Gln Val Ile Leu Val Gln Gln Gly Gln Val Val Lys Leu 
        275                 280                 285             


Met Glu Pro His Arg Pro Glu Arg Gln Asp Glu Lys Ala Arg Ile Glu 
    290                 295                 300                 


Ala Leu Gly Gly Phe Val Ser His Met Asp Cys Trp Arg Val Asn Gly 
305                 310                 315                 320 


Thr Leu Ala Val Ser Arg Ala Ile Gly Asp Val Phe Gln Lys Pro Tyr 
                325                 330                 335     


Val Ser Gly Glu Ala Asp Ala Ala Ser Arg Ala Leu Thr Gly Ser Glu 
            340                 345                 350         


Asp Tyr Leu Leu Leu Ala Cys Asp Gly Phe Phe Asp Val Val Pro His 
        355                 360                 365             


Gln Glu Val Val Gly Leu Val Gln Ser His Leu Thr Arg Gln Gln Gly 
    370                 375                 380                 


Ser Gly Leu Arg Val Ala Glu Glu Leu Val Ala Ala Ala Arg Glu Arg 
385                 390                 395                 400 


Gly Ser His Asp Asn Ile Thr Val Met Val Val Phe Leu Arg Asp Pro 
                405                 410                 415     


Gln Glu Leu Leu Glu Gly Gly Asn Gln Gly Glu Gly Asp Pro Gln Ala 
            420                 425                 430         


Glu Gly Arg Arg Gln Asp Leu Pro Ser Ser Leu Pro Glu Pro Glu Thr 
        435                 440                 445             


Gln Ala Pro Pro Arg Ser 
    450                 


<210>  863
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  863

Met Ala Glu Ala Gly Ala Gly Leu Ser Glu Thr Val Thr Glu Thr Thr 
1               5                   10                  15      


Val Thr Val Thr Thr Glu Pro Glu Asn Arg Ser Leu Thr Ile Lys Leu 
            20                  25                  30          


Arg Lys Arg Lys Pro Glu Lys Lys Val Glu Trp Thr Ser Asp Thr Val 
        35                  40                  45              


Asp Asn Glu His Met Gly Arg Arg Ser Ser Lys Cys Cys Cys Ile Tyr 
    50                  55                  60                  


Glu Lys Pro Arg Ala Phe Gly Glu Ser Ser Thr Glu Ser Asp Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Cys Gly His Thr His Cys Val Arg Gly His Arg Lys 
                85                  90                  95      


Gly Arg Arg Arg Ala Thr Leu Gly Pro Thr Pro Thr Thr Pro Pro Gln 
            100                 105                 110         


Pro Pro Asp Pro Ser Gln Pro Pro Pro Gly Pro Met Gln His 
        115                 120                 125     


<210>  864
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  864

Met Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys 
1               5                   10                  15      


Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro 
            20                  25                  30          


Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp 
        35                  40                  45              


Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly 
    50                  55                  60                  


Leu Met Lys Ile Asp Glu Pro Ser Thr Pro Tyr His Ser Met Met Gly 
65                  70                  75                  80  


Asp Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala 
                85                  90                  95      


Pro Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro 
            100                 105                 110         


Lys Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp 
        115                 120                 125             


Leu Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg 
    130                 135                 140                 


Lys Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu 
145                 150                 155                 160 


Ile Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu 
                165                 170                 175     


Thr Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser 
            180                 185                 190         


Thr Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
        195                 200                 205 


<210>  865
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  865

Met Ser Ser Ser Ser Pro Pro Ala Gly Ala Ala Ser Ala Ala Ile Ser 
1               5                   10                  15      


Ala Ser Glu Lys Val Asp Gly Phe Thr Arg Lys Ser Val Arg Lys Ala 
            20                  25                  30          


Gln Arg Gln Lys Arg Ser Gln Gly Ser Ser Gln Phe Arg Ser Gln Gly 
        35                  40                  45              


Ser Gln Ala Glu Leu His Pro Leu Pro Gln Leu Lys Asp Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gln Gln Glu Leu Phe Cys Gln Lys Leu Gln Gln Cys Cys Ile 
65                  70                  75                  80  


Leu Phe Asp Phe Met Asp Ser Val Ser Asp Leu Lys Ser Lys Glu Ile 
                85                  90                  95      


Lys Arg Ala Thr Leu Asn Glu Leu Val Glu Tyr Val Ser Thr Asn Arg 
            100                 105                 110         


Gly Val Ile Val Glu Ser Ala Tyr Ser Asp Ile Val Lys Met Ile Ser 
        115                 120                 125             


Ala Asn Ile Phe Arg Thr Leu Pro Pro Ser Asp Asn Pro Asp Phe Asp 
    130                 135                 140                 


Pro Glu Glu Asp Glu Pro Thr Leu Glu Ala Ser Trp Pro His Ile Gln 
145                 150                 155                 160 


Leu Val Tyr Glu Phe Phe Leu Arg Phe Leu Glu Ser Pro Asp Phe Gln 
                165                 170                 175     


Pro Ser Ile Ala Lys Arg Tyr Ile Asp Gln Lys Phe Val Gln Gln Leu 
            180                 185                 190         


Leu Glu Leu Phe Asp Ser Glu Asp Pro Arg Glu Arg Asp Phe Leu Lys 
        195                 200                 205             


Thr Val Leu His Arg Ile Tyr Gly Lys Phe Leu Gly Leu Arg Ala Phe 
    210                 215                 220                 


Ile Arg Lys Gln Ile Asn Asn Ile Phe Leu Arg Phe Ile Tyr Glu Thr 
225                 230                 235                 240 


Glu His Phe Asn Gly Val Ala Glu Leu Leu Glu Ile Leu Gly Ser Ile 
                245                 250                 255     


Ile Asn Gly Phe Ala Leu Pro Leu Lys Ala Glu His Lys Gln Phe Leu 
            260                 265                 270         


Met Lys Val Leu Ile Pro Met His Thr Ala Lys Gly Leu Ala Leu Phe 
        275                 280                 285             


His Ala Gln Leu Ala Tyr Cys Val Val Gln Phe Leu Glu Lys Asp Thr 
    290                 295                 300                 


Thr Leu Thr Glu Pro Val Ile Arg Gly Leu Leu Lys Phe Trp Pro Lys 
305                 310                 315                 320 


Thr Cys Ser Gln Lys Glu Val Met Phe Leu Gly Glu Ile Glu Glu Ile 
                325                 330                 335     


Leu Asp Val Ile Glu Pro Thr Gln Phe Lys Lys Ile Glu Glu Pro Leu 
            340                 345                 350         


Phe Lys Gln Ile Ser Lys Cys Val Ser Ser Ser His Phe Gln Val Ala 
        355                 360                 365             


Glu Arg Ala Leu Tyr Phe Trp Asn Asn Glu Tyr Ile Leu Ser Leu Ile 
    370                 375                 380                 


Glu Glu Asn Ile Asp Lys Ile Leu Pro Ile Met Phe Ala Ser Leu Tyr 
385                 390                 395                 400 


Lys Ile Ser Lys Glu His Trp Asn Pro Thr Ile Val Ala Leu Val Tyr 
                405                 410                 415     


Asn Val Leu Lys Thr Leu Met Glu Met Asn Gly Lys Leu Phe Asp Asp 
            420                 425                 430         


Leu Thr Ser Ser Tyr Lys Ala Glu Arg Gln Arg Glu Lys Lys Lys Glu 
        435                 440                 445             


Leu Glu Arg Glu Glu Leu Trp Lys Lys Leu Glu Glu Leu Lys Leu Lys 
    450                 455                 460                 


Lys Ala Leu Glu Lys Gln Asn Ser Ala Tyr Asn Met His Ser Ile Leu 
465                 470                 475                 480 


Ser Asn Thr Ser Ala Glu 
                485     


<210>  866
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  866

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  867
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  867

Met Ala Asp Leu Ser Leu Leu Gln Glu Asp Leu Gln Glu Asp Ala Asp 
1               5                   10                  15      


Gly Ser Leu Asp Phe Val Ser Gln Asp Glu Met Leu Thr Pro Leu Gly 
            20                  25                  30          


Arg Leu Asp Lys Tyr Ala Ala Ser Glu Asn Ile Phe Asn Arg Gln Met 
        35                  40                  45              


Val Ala Arg Ser Leu Leu Asp Thr Leu Arg Glu Val Cys Asp Asp Glu 
    50                  55                  60                  


Arg Asp Cys Ile Ala Val Leu Glu Arg Ile Ser Arg Leu Ala Asp Asp 
65                  70                  75                  80  


Ser Glu Pro Thr Val Arg Ala Glu Leu Met Glu Gln Val Pro His Ile 
                85                  90                  95      


Ala Leu Phe Cys Gln Glu Asn Arg Pro Ser Ile Pro Tyr Ala Phe Ser 
            100                 105                 110         


Lys Phe Leu Leu Pro Ile Val Val Arg Tyr Leu Ala Asp Gln Asn Asn 
        115                 120                 125             


Gln Val Arg Lys Thr Ser Gln Ala Ala Leu Leu Ala Leu Leu Glu Gln 
    130                 135                 140                 


Glu Leu Ile Glu Arg Phe Asp Val Glu Thr Lys Val Cys Pro Val Leu 
145                 150                 155                 160 


Ile Glu Leu Thr Ala Pro Asp Ser Asn Asp Asp Val Lys Thr Glu Ala 
                165                 170                 175     


Val Ala Ile Met Cys Lys Met Ala Pro Met Val Gly Lys Asp Ile Thr 
            180                 185                 190         


Glu Arg Leu Ile Leu Pro Arg Phe Cys Glu Met Cys Cys Asp Cys Arg 
        195                 200                 205             


Met Phe His Val Arg Lys Val Cys Ala Ala Asn Phe Gly Asp Ile Cys 
    210                 215                 220                 


Ser Val Val Gly Gln Gln Ala Thr Glu Glu Met Leu Leu Pro Arg Phe 
225                 230                 235                 240 


Phe Gln Leu Cys Ser Asp Asn Val Trp Gly Val Arg Lys Ala Cys Ala 
                245                 250                 255     


Glu Cys Phe Met Ala Val Ser Cys Ala Thr Cys Gln Glu Ile Arg Arg 
            260                 265                 270         


Thr Lys Leu Ser Ala Leu Phe Ile Asn Leu Ile Ser Asp Pro Ser Arg 
        275                 280                 285             


Trp Val Arg Gln Ala Ala Phe Gln Ser Leu Gly Pro Phe Ile Ser Thr 
    290                 295                 300                 


Phe Ala Asn Pro Ser Ser Ser Gly Gln Tyr Phe Lys Glu Glu Ser Lys 
305                 310                 315                 320 


Ser Ser Glu Glu Met Ser Val Glu Asn Lys Asn Arg Thr Arg Asp Gln 
                325                 330                 335     


Glu Ala Pro Glu Asp Val Gln Val Arg Pro Glu Asp Thr Pro Ser Asp 
            340                 345                 350         


Leu Ser Val Ser Asn Ser Ser Val Ile Leu Glu Asn Thr Met Glu Asp 
        355                 360                 365             


His Ala Ala Glu Ala Ser Gly Lys Pro Leu Gly Glu Ile Ser Val Pro 
    370                 375                 380                 


Leu Asp Ser Ser Leu Leu Cys Thr Leu Ser Ser Glu Ser His Gln Glu 
385                 390                 395                 400 


Ala Ala Ser Asn Glu Asn Asp Lys Lys Pro Gly Asn Tyr Lys Ser Met 
                405                 410                 415     


Leu Arg Pro Glu Val Gly Thr Thr Ser Gln Asp Ser Ala Leu Leu Asp 
            420                 425                 430         


Gln Glu Leu Tyr Asn Ser Phe His Phe Trp Arg Thr Pro Leu Pro Glu 
        435                 440                 445             


Ile Asp Leu Asp Ile Glu Leu Glu Gln Asn Ser Gly Gly Lys Pro Ser 
    450                 455                 460                 


Pro Glu Gly Pro Glu Glu Glu Ser Glu Gly Pro Val Pro Ser Ser Pro 
465                 470                 475                 480 


Asn Ile Thr Met Ala Thr Arg Lys Glu Leu Glu Glu Met Ile Glu Asn 
                485                 490                 495     


Leu Glu Pro His Ile Asp Asp Pro Asp Val Lys Ala Gln Val Glu Val 
            500                 505                 510         


Leu Ser Ala Ala Leu Arg Ala Ser Ser Leu Asp Ala His Glu Glu Thr 
        515                 520                 525             


Ile Ser Ile Glu Lys Arg Ser Asp Leu Gln Asp Glu Leu Asp Ile Asn 
    530                 535                 540                 


Glu Leu Pro Asn Cys Lys Ile Asn Gln Glu Asp Ser Val Pro Leu Ile 
545                 550                 555                 560 


Ser Asp Ala Val Glu Asn Met Asp Ser Thr Leu His Tyr Ile His Ser 
                565                 570                 575     


Asp Ser Asp Leu Ser Asn Asn Ser Ser Phe Ser Pro Asp Glu Glu Arg 
            580                 585                 590         


Arg Thr Lys Val Gln Asp Val Val Pro Gln Ala Leu Leu Asp Gln Tyr 
        595                 600                 605             


Leu Ser Met Thr Asp Pro Ser Arg Ala Gln Thr Val Asp Thr Glu Ile 
    610                 615                 620                 


Ala Lys His Cys Ala Tyr Ser Leu Pro Gly Val Ala Leu Thr Leu Gly 
625                 630                 635                 640 


Arg Gln Asn Trp His Cys Leu Arg Glu Thr Tyr Glu Thr Leu Ala Ser 
                645                 650                 655     


Asp Met Gln Trp Lys Val Arg Arg Thr Leu Ala Phe Ser Ile His Glu 
            660                 665                 670         


Leu Ala Val Ile Leu Gly Asp Gln Leu Thr Ala Ala Asp Leu Val Pro 
        675                 680                 685             


Ile Phe Asn Gly Phe Leu Lys Asp Leu Asp Glu Val Arg Ile Gly Val 
    690                 695                 700                 


Leu Lys His Leu His Asp Phe Leu Lys Leu Leu His Ile Asp Lys Arg 
705                 710                 715                 720 


Arg Glu Tyr Leu Tyr Gln Leu Gln Glu Phe Leu Val Thr Asp Asn Ser 
                725                 730                 735     


Arg Asn Trp Arg Phe Arg Ala Glu Leu Ala Glu Gln Leu Ile Leu Leu 
            740                 745                 750         


Leu Glu Leu Tyr Ser Pro Arg Asp Val Tyr Asp Tyr Leu Arg Pro Ile 
        755                 760                 765             


Ala Leu Asn Leu Cys Ala Asp Lys Val Ser Ser Val Arg Trp Ile Ser 
    770                 775                 780                 


Tyr Lys Leu Val Ser Glu Met Val Lys Lys Leu His Ala Ala Thr Pro 
785                 790                 795                 800 


Pro Thr Phe Gly Val Asp Leu Ile Asn Glu Leu Val Glu Asn Phe Gly 
                805                 810                 815     


Arg Cys Pro Lys Trp Ser Gly Arg Gln Ala Phe Val Phe Val Cys Gln 
            820                 825                 830         


Thr Val Ile Glu Asp Asp Cys Leu Pro Met Asp Gln Phe Ala Val His 
        835                 840                 845             


Leu Met Pro His Leu Leu Thr Leu Ala Asn Asp Arg Val Pro Asn Val 
    850                 855                 860                 


Arg Val Leu Leu Ala Lys Thr Leu Arg Gln Thr Leu Leu Glu Lys Asp 
865                 870                 875                 880 


Tyr Phe Leu Ala Ser Ala Ser Cys His Gln Glu Ala Val Glu Gln Thr 
                885                 890                 895     


Ile Met Ala Leu Gln Met Asp Arg Asp Ser Asp Val Lys Tyr Phe Ala 
            900                 905                 910         


Ser Ile His Pro Ala Ser Thr Lys Ile Ser Glu Asp Ala Met Ser Thr 
        915                 920                 925             


Ala Ser Ser Thr Tyr 
    930             


<210>  868
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  868

Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile 
        195                 200                 205             


Trp Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro 
    210                 215                 220                 


Phe Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly 
225                 230                 235                 240 


Ile Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu 
                245                 250                 255     


Lys His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp 
            260                 265                 270         


Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe 
        275                 280                 285             


Pro Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu 
    290                 295                 300                 


Lys Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser 
305                 310                 315                 320 


Cys Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His 
                325                 330                 335     


Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr 
            340                 345                 350         


Leu Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr 
        355                 360                 365             


Arg Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg 
    370                 375                 380                 


Ala Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln 
385                 390                 395                 400 


Gly Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg 
                405                 410                 415     


Pro Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp 
            420                 425                 430         


Tyr Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys 
        435                 440                 445             


Asn Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln 
    450                 455                 460                 


Val Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu 
465                 470                 475                 480 


Ile Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser 
                485                 490                 495     


Val Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala 
            500                 505                 510         


Gln Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu 
        515                 520                 525             


Asp Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile 
    530                 535                 540                 


Glu Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
545                 550                 555                 


<210>  869
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  869

Met Gly Ser Ala Val Met Asp Thr Lys Lys Lys Lys Asp Val Ser Ser 
1               5                   10                  15      


Pro Gly Gly Ser Gly Gly Lys Lys Asn Ala Ser Gln Lys Arg Arg Ser 
            20                  25                  30          


Leu Arg Val His Ile Pro Asp Leu Ser Ser Phe Ala Met Pro Leu Leu 
        35                  40                  45              


Asp Gly Asp Leu Glu Gly Ser Gly Lys His Ser Ser Arg Lys Val Asp 
    50                  55                  60                  


Ser Pro Phe Gly Pro Gly Ser Pro Ser Lys Gly Phe Phe Ser Arg Gly 
65                  70                  75                  80  


Pro Gln Pro Arg Pro Ser Ser Pro Met Ser Ala Pro Val Arg Pro Lys 
                85                  90                  95      


Thr Ser Pro Gly Ser Pro Lys Thr Val Phe Pro Phe Ser Tyr Gln Glu 
            100                 105                 110         


Ser Pro Pro Arg Ser Pro Arg Arg Met Ser Phe Ser Gly Ile Phe Arg 
        115                 120                 125             


Ser Ser Ser Lys Glu Ser Ser Pro Asn Ser Asn Pro Ala Thr Ser Pro 
    130                 135                 140                 


Gly Gly Ile Arg Phe Phe Ser Arg Ser Arg Lys Thr Ser Gly Leu Ser 
145                 150                 155                 160 


Ser Ser Pro Ser Thr Pro Thr Gln Val Thr Lys Gln His Thr Phe Pro 
                165                 170                 175     


Leu Glu Ser Tyr Lys His Glu Pro Glu Arg Leu Glu Asn Arg Ile Tyr 
            180                 185                 190         


Ala Ser Ser Ser Pro Pro Asp Thr Gly Gln Arg Phe Cys Pro Ser Ser 
        195                 200                 205             


Phe Gln Ser Pro Thr Arg Pro Pro Leu Ala Ser Pro Thr His Tyr Ala 
    210                 215                 220                 


Pro Ser Lys Ala Ala Ala Leu Ala Ala Ala Leu Gly Pro Ala Glu Ala 
225                 230                 235                 240 


Gly Met Leu Glu Lys Leu Glu Phe Glu Asp Glu Ala Val Glu Asp Ser 
                245                 250                 255     


Glu Ser Gly Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp 
            260                 265                 270         


Ile Val Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln 
        275                 280                 285             


Val Lys Lys Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala 
    290                 295                 300                 


Pro Leu Trp Glu Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr Ile 
305                 310                 315                 320 


Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Pro Met Val 
                325                 330                 335     


Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu Leu 
            340                 345                 350         


Tyr Leu Gln Glu Thr Phe Lys Pro Leu Val Asn Ile Ser Pro Asp Ala 
        355                 360                 365             


Ser Leu Phe Asp Ala Val Tyr Ser Leu Ile Lys Asn Lys Ile His Arg 
    370                 375                 380                 


Leu Pro Val Ile Asp Pro Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr 
385                 390                 395                 400 


His Lys Arg Ile Leu Lys Phe Leu Gln Leu Phe Met Ser Asp Met Pro 
                405                 410                 415     


Lys Pro Ala Phe Met Lys Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr 
            420                 425                 430         


Tyr His Asn Ile Ala Phe Ile His Pro Asp Thr Pro Ile Ile Lys Ala 
        435                 440                 445             


Leu Asn Ile Phe Val Glu Arg Arg Ile Ser Ala Leu Pro Val Val Asp 
    450                 455                 460                 


Glu Ser Gly Lys Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn 
465                 470                 475                 480 


Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln 
                485                 490                 495     


Ala Leu Gln His Arg Ser Gln Tyr Phe Glu Gly Val Val Lys Cys Asn 
            500                 505                 510         


Lys Leu Glu Ile Leu Glu Thr Ile Val Asp Arg Ile Val Arg Ala Glu 
        515                 520                 525             


Val His Arg Leu Val Val Val Asn Glu Ala Asp Ser Ile Val Gly Ile 
    530                 535                 540                 


Ile Ser Leu Ser Asp Ile Leu Gln Ala Leu Ile Leu Thr Pro Ala Gly 
545                 550                 555                 560 


Ala Lys Gln Lys Glu Thr Glu Thr Glu 
                565                 


<210>  870
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  870

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  871
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  871

Met Ala Thr Ser Gly Asp Cys Pro Arg Ser Glu Ser Gln Gly Glu Glu 
1               5                   10                  15      


Pro Ala Glu Cys Ser Glu Ala Gly Leu Leu Gln Glu Gly Val Gln Pro 
            20                  25                  30          


Glu Glu Phe Val Ala Ile Ala Asp Tyr Ala Ala Thr Asp Glu Thr Gln 
        35                  40                  45              


Leu Ser Phe Leu Arg Gly Glu Lys Ile Leu Ile Leu Arg Gln Thr Thr 
    50                  55                  60                  


Ala Asp Trp Trp Trp Gly Glu Arg Ala Gly Cys Cys Gly Tyr Ile Pro 
65                  70                  75                  80  


Ala Asn His Val Gly Lys His Val Asp Glu Tyr Asp Pro Glu Asp Thr 
                85                  90                  95      


Trp Gln Asp Glu Glu Tyr Phe Gly Ser Tyr Gly Thr Leu Lys Leu His 
            100                 105                 110         


Leu Glu Met Leu Ala Asp Gln Pro Arg Thr Thr Lys Tyr His Ser Val 
        115                 120                 125             


Ile Leu Gln Asn Lys Glu Ser Leu Thr Asp Lys Val Ile Leu Asp Val 
    130                 135                 140                 


Gly Cys Gly Thr Gly Ile Ile Ser Leu Phe Cys Ala His Tyr Ala Arg 
145                 150                 155                 160 


Pro Arg Ala Val Tyr Ala Val Glu Ala Ser Glu Met Ala Gln His Thr 
                165                 170                 175     


Gly Gln Leu Val Leu Gln Asn Gly Phe Ala Asp Ile Ile Thr Val Tyr 
            180                 185                 190         


Gln Gln Lys Val Glu Asp Val Val Leu Pro Glu Lys Val Asp Val Leu 
        195                 200                 205             


Val Ser Glu Trp Met Gly Thr Cys Leu Leu Phe Glu Phe Met Ile Glu 
    210                 215                 220                 


Ser Ile Leu Tyr Ala Arg Asp Ala Trp Leu Lys Glu Asp Gly Val Ile 
225                 230                 235                 240 


Trp Pro Thr Met Ala Ala Leu His Leu Val Pro Cys Ser Ala Asp Lys 
                245                 250                 255     


Asp Tyr Arg Ser Lys Val Leu Phe Trp Asp Asn Ala Tyr Glu Phe Asn 
            260                 265                 270         


Leu Ser Ala Leu Lys Ser Leu Ala Val Lys Glu Phe Phe Ser Lys Pro 
        275                 280                 285             


Lys Tyr Asn His Ile Leu Lys Pro Glu Asp Cys Leu Ser Glu Pro Cys 
    290                 295                 300                 


Thr Ile Leu Gln Leu Asp Met Arg Thr Val Gln Ile Ser Asp Leu Glu 
305                 310                 315                 320 


Thr Leu Arg Gly Glu Leu Arg Phe Asp Ile Arg Lys Ala Gly Thr Leu 
                325                 330                 335     


His Gly Phe Thr Ala Trp Phe Ser Val His Phe Gln Ser Leu Gln Glu 
            340                 345                 350         


Gly Gln Pro Pro Gln Val Leu Ser Thr Gly Pro Phe His Pro Thr Thr 
        355                 360                 365             


His Trp Lys Gln Thr Leu Phe Met Met Asp Asp Pro Val Pro Val His 
    370                 375                 380                 


Thr Gly Asp Val Val Thr Gly Ser Val Val Leu Gln Arg Asn Pro Val 
385                 390                 395                 400 


Trp Arg Arg His Met Ser Val Ala Leu Ser Trp Ala Val Thr Ser Arg 
                405                 410                 415     


Gln Asp Pro Thr Ser Gln Lys Val Gly Glu Lys Val Phe Pro Ile Trp 
            420                 425                 430         


Arg 
    


<210>  872
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  872

Met Glu Asp Tyr Leu Gln Gly Cys Arg Ala Ala Leu Gln Glu Ser Arg 
1               5                   10                  15      


Pro Leu His Val Val Leu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr 
            20                  25                  30          


Val Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala 
        35                  40                  45              


Glu Glu Val Phe Val Pro Val Leu Asn Ile Lys Arg Ser Glu Leu Pro 
    50                  55                  60                  


Leu Arg Gly Asp Ile Val Phe Phe Leu Gln Lys Val His Ile Pro Glu 
65                  70                  75                  80  


Ser Ile Leu Ile Phe Arg Asp Glu Ile Asp Leu His Ala Leu Tyr Gln 
                85                  90                  95      


Ala Gly Gln Leu Thr Leu Ile Leu Val Asp His His Ile Leu Ser Lys 
            100                 105                 110         


Ser Asp Thr Ala Leu Glu Glu Ala Val Ala Glu Val Leu Asp His Arg 
        115                 120                 125             


Pro Ile Glu Pro Lys His Cys Pro Pro Cys His Val Ser Val Glu Leu 
    130                 135                 140                 


Val Gly Ser Cys Ala Thr Leu Val Thr Glu Arg Ile Leu Gln Gly Ala 
145                 150                 155                 160 


Pro Glu Ile Leu Asp Arg Gln Thr Ala Ala Leu Leu His Gly Thr Ile 
                165                 170                 175     


Ile Leu Asp Cys Val Asn Met Asp Leu Lys Ile Gly Lys Ala Thr Pro 
            180                 185                 190         


Lys Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu 
        195                 200                 205             


Pro Lys Arg Asn Asp Ile Phe Asp Ser Leu Gln Lys Ala Lys Phe Asp 
    210                 215                 220                 


Val Ser Gly Leu Thr Thr Glu Gln Met Leu Arg Lys Asp Gln Lys Thr 
225                 230                 235                 240 


Ile Tyr Arg Gln Gly Val Lys Val Ala Ile Ser Ala Ile Tyr Met Asp 
                245                 250                 255     


Leu Glu Ala Phe Leu Gln Arg Ser Asn Leu Leu Ala Asp Leu His Ala 
            260                 265                 270         


Phe Cys Gln Ala His Ser Tyr Asp Val Leu Val Ala Met Thr Ile Phe 
        275                 280                 285             


Phe Asn Thr His Asn Glu Pro Val Arg Gln Leu Ala Ile Phe Cys Pro 
    290                 295                 300                 


His Val Ala Leu Gln Thr Thr Ile Cys Glu Val Leu Glu Arg Ser His 
305                 310                 315                 320 


Ser Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu 
                325                 330                 335     


His Ala Tyr Leu Gln Gly Asn Thr Gln Val Ser Arg Lys Lys Leu Leu 
            340                 345                 350         


Pro Leu Leu Gln Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys Ile 
        355                 360                 365             


Pro Ser Gly Gln Pro Glu Thr Ala Asp Val Ser Arg Glu Gln Val Asp 
    370                 375                 380                 


Lys Glu Leu Asp Arg Ala Ser Asn Ser Leu Ile Ser Gly Leu Ser Gln 
385                 390                 395                 400 


Asp Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val 
                405                 410                 415     


Asp Glu Cys Pro Leu Asp Gln Gly Leu Pro Lys Leu Ser Ala Glu Ala 
            420                 425                 430         


Val Phe Glu Lys Cys Ser Gln Ile Ser Leu Ser Gln Ser Thr Thr Ala 
        435                 440                 445             


Ser Leu Ser Lys Lys 
    450             


<210>  873
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  873

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
            260                 265                 270         


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
        275                 280                 285             


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
    290                 295                 300                 


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
305                 310                 315                 320 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
                325                 330                 335     


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
            340                 345                 350         


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
        355                 360                 365             


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
    370                 375                 380                 


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
385                 390                 395                 400 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
                405                 410                 415     


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
            420                 425                 430         


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
        435                 440                 445             


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
    450                 455                 460                 


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
465                 470                 475                 480 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
                485                 490                 495     


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
            500                 505                 510         


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 


<210>  874
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  874

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  875
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  875

Met Met Pro Gln Leu Gln Phe Lys Asp Ala Phe Trp Cys Arg Asp Phe 
1               5                   10                  15      


Thr Ala His Thr Gly Tyr Glu Val Leu Leu Gln Arg Leu Leu Asp Gly 
            20                  25                  30          


Arg Lys Met Cys Lys Asp Met Glu Glu Leu Leu Arg Gln Arg Ala Gln 
        35                  40                  45              


Ala Glu Glu Arg Tyr Gly Lys Glu Leu Val Gln Ile Ala Arg Lys Ala 
    50                  55                  60                  


Gly Gly Gln Thr Glu Ile Asn Ser Leu Arg Ala Ser Phe Asp Ser Leu 
65                  70                  75                  80  


Lys Gln Gln Met Glu Asn Val Gly Ser Ser His Ile Gln Leu Ala Leu 
                85                  90                  95      


Thr Leu Arg Glu Glu Leu Arg Ser Leu Glu Glu Phe Arg Glu Arg Gln 
            100                 105                 110         


Lys Glu Gln Arg Lys Lys Tyr Glu Ala Val Met Asp Arg Val Gln Lys 
        115                 120                 125             


Ser Lys Leu Ser Leu Tyr Lys Lys Ala Met Glu Ser Lys Lys Thr Tyr 
    130                 135                 140                 


Glu Gln Lys Cys Arg Asp Ala Asp Asp Ala Glu Gln Ala Phe Glu Arg 
145                 150                 155                 160 


Ile Ser Ala Asn Gly His Gln Lys Gln Val Glu Lys Ser Gln Asn Lys 
                165                 170                 175     


Ala Arg Gln Cys Lys Asp Ser Ala Thr Glu Ala Glu Arg Val Tyr Arg 
            180                 185                 190         


Gln Ser Ile Ala Gln Leu Glu Lys Val Arg Ala Glu Trp Glu Gln Glu 
        195                 200                 205             


His Arg Thr Thr Cys Glu Ala Phe Gln Leu Gln Glu Phe Asp Arg Leu 
    210                 215                 220                 


Thr Ile Leu Arg Asn Ala Leu Trp Val His Ser Asn Gln Leu Ser Met 
225                 230                 235                 240 


Gln Cys Val Lys Asp Asp Glu Leu Tyr Glu Glu Val Arg Leu Thr Leu 
                245                 250                 255     


Glu Gly Cys Ser Ile Asp Ala Asp Ile Asp Ser Phe Ile Gln Ala Lys 
            260                 265                 270         


Ser Thr Gly Thr Glu Pro Pro Ala Pro Val Pro Tyr Gln Asn Tyr Tyr 
        275                 280                 285             


Asp Arg Glu Val Thr Pro Leu Thr Ser Ser Pro Gly Ile Gln Pro Ser 
    290                 295                 300                 


Cys Gly Met Ile Lys Arg Phe Ser Gly Leu Leu His Gly Ser Pro Lys 
305                 310                 315                 320 


Thr Thr Ser Leu Ala Ala Ser Ala Ala Ser Thr Glu Thr Leu Thr Pro 
                325                 330                 335     


Thr Pro Glu Arg Asn Glu Gly Val Tyr Thr Ala Ile Ala Val Gln Glu 
            340                 345                 350         


Ile Gln Gly Asn Pro Ala Ser Pro Ala Gln Glu Tyr Arg Ala Leu Tyr 
        355                 360                 365             


Asp Tyr Thr Ala Gln Asn Pro Asp Glu Leu Asp Leu Ser Ala Gly Asp 
    370                 375                 380                 


Ile Leu Glu Val Ile Leu Glu Gly Glu Asp Gly Trp Trp Thr Val Glu 
385                 390                 395                 400 


Arg Asn Gly Gln Arg Gly Phe Val Pro Gly Ser Tyr Leu Glu Lys Leu 
                405                 410                 415     


<210>  876
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  876

Met Glu Pro His Asp Ser Ser His Met Asp Ser Glu Phe Arg Tyr Thr 
1               5                   10                  15      


Leu Phe Pro Ile Val Tyr Ser Ile Ile Phe Val Leu Gly Val Ile Ala 
            20                  25                  30          


Asn Gly Tyr Val Leu Trp Val Phe Ala Arg Leu Tyr Pro Cys Lys Lys 
        35                  40                  45              


Phe Asn Glu Ile Lys Ile Phe Met Val Asn Leu Thr Met Ala Asp Met 
    50                  55                  60                  


Leu Phe Leu Ile Thr Leu Pro Leu Trp Ile Val Tyr Tyr Gln Asn Gln 
65                  70                  75                  80  


Gly Asn Trp Ile Leu Pro Lys Phe Leu Cys Asn Val Ala Gly Cys Leu 
                85                  90                  95      


Phe Phe Ile Asn Thr Tyr Cys Ser Val Ala Phe Leu Gly Val Ile Thr 
            100                 105                 110         


Tyr Asn Arg Phe Gln Ala Val Thr Arg Pro Ile Lys Thr Ala Gln Ala 
        115                 120                 125             


Asn Thr Arg Lys Arg Gly Ile Ser Leu Ser Leu Val Ile Trp Val Ala 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr 
145                 150                 155                 160 


Val Pro Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys Phe Glu His 
                165                 170                 175     


Tyr Glu Lys Gly Ser Val Pro Val Leu Ile Ile His Ile Phe Ile Val 
            180                 185                 190         


Phe Ser Phe Phe Leu Val Phe Leu Ile Ile Leu Phe Cys Asn Leu Val 
        195                 200                 205             


Ile Ile Arg Thr Leu Leu Met Gln Pro Val Gln Gln Gln Arg Asn Ala 
    210                 215                 220                 


Glu Val Lys Arg Arg Ala Leu Trp Met Val Cys Thr Val Leu Ala Val 
225                 230                 235                 240 


Phe Ile Ile Cys Phe Val Pro His His Val Val Gln Leu Pro Trp Thr 
                245                 250                 255     


Leu Ala Glu Leu Gly Phe Gln Asp Ser Lys Phe His Gln Ala Ile Asn 
            260                 265                 270         


Asp Ala His Gln Val Thr Leu Cys Leu Leu Ser Thr Asn Cys Val Leu 
        275                 280                 285             


Asp Pro Val Ile Tyr Cys Phe Leu Thr Lys Lys Phe Arg Lys His Leu 
    290                 295                 300                 


Thr Glu Lys Phe Tyr Ser Met Arg Ser Ser Arg Lys Cys Ser Arg Ala 
305                 310                 315                 320 


Thr Thr Asp Thr Val Thr Glu Val Val Val Pro Phe Asn Gln Ile Pro 
                325                 330                 335     


Gly Asn Ser Leu Lys Asn 
            340         


<210>  877
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  877

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  878
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  878

Met Ser Thr Pro Gly Val Asn Ser Ser Ala Ser Leu Ser Pro Asp Arg 
1               5                   10                  15      


Leu Asn Ser Pro Val Thr Ile Pro Ala Val Met Phe Ile Phe Gly Val 
            20                  25                  30          


Val Gly Asn Leu Val Ala Ile Val Val Leu Cys Lys Ser Arg Lys Glu 
        35                  40                  45              


Gln Lys Glu Thr Thr Phe Tyr Thr Leu Val Cys Gly Leu Ala Val Thr 
    50                  55                  60                  


Asp Leu Leu Gly Thr Leu Leu Val Ser Pro Val Thr Ile Ala Thr Tyr 
65                  70                  75                  80  


Met Lys Gly Gln Trp Pro Gly Gly Gln Pro Leu Cys Glu Tyr Ser Thr 
                85                  90                  95      


Phe Ile Leu Leu Phe Phe Ser Leu Ser Gly Leu Ser Ile Ile Cys Ala 
            100                 105                 110         


Met Ser Val Glu Arg Tyr Leu Ala Ile Asn His Ala Tyr Phe Tyr Ser 
        115                 120                 125             


His Tyr Val Asp Lys Arg Leu Ala Gly Leu Thr Leu Phe Ala Val Tyr 
    130                 135                 140                 


Ala Ser Asn Val Leu Phe Cys Ala Leu Pro Asn Met Gly Leu Gly Ser 
145                 150                 155                 160 


Ser Arg Leu Gln Tyr Pro Asp Thr Trp Cys Phe Ile Asp Trp Thr Thr 
                165                 170                 175     


Asn Val Thr Ala His Ala Ala Tyr Ser Tyr Met Tyr Ala Gly Phe Ser 
            180                 185                 190         


Ser Phe Leu Ile Leu Ala Thr Val Leu Cys Asn Val Leu Val Cys Gly 
        195                 200                 205             


Ala Leu Leu Arg Met His Arg Gln Phe Met Arg Arg Thr Ser Leu Gly 
    210                 215                 220                 


Thr Glu Gln His His Ala Ala Ala Ala Ala Ser Val Ala Ser Arg Gly 
225                 230                 235                 240 


His Pro Ala Ala Ser Pro Ala Leu Pro Arg Leu Ser Asp Phe Arg Arg 
                245                 250                 255     


Arg Arg Ser Phe Arg Arg Ile Ala Gly Ala Glu Ile Gln Met Val Ile 
            260                 265                 270         


Leu Leu Ile Ala Thr Ser Leu Val Val Leu Ile Cys Ser Ile Pro Leu 
        275                 280                 285             


Val Val Arg Val Phe Val Asn Gln Leu Tyr Gln Pro Ser Leu Glu Arg 
    290                 295                 300                 


Glu Val Ser Lys Asn Pro Asp Leu Gln Ala Ile Arg Ile Ala Ser Val 
305                 310                 315                 320 


Asn Pro Ile Leu Asp Pro Trp Ile Tyr Ile Leu Leu Arg Lys Thr Val 
                325                 330                 335     


Leu Ser Lys Ala Ile Glu Lys Ile Lys Cys Leu Phe Cys Arg Ile Gly 
            340                 345                 350         


Gly Ser Arg Arg Glu Arg Ser Gly Gln His Cys Ser Asp Ser Gln Arg 
        355                 360                 365             


Thr Ser Ser Ala Met Ser Gly His Ser Arg Ser Phe Ile Ser Arg Glu 
    370                 375                 380                 


Leu Lys Glu Ile Ser Ser Thr Ser Gln Thr Leu Leu Pro Asp Leu Ser 
385                 390                 395                 400 


Leu Pro Asp Leu Ser Glu Asn Gly Leu Gly Gly Arg Asn Leu Leu Pro 
                405                 410                 415     


Gly Val Pro Gly Met Gly Leu Ala Gln Glu Asp Thr Thr Ser Leu Arg 
            420                 425                 430         


Thr Leu Arg Ile Ser Glu Thr Ser Asp Ser Ser Gln Gly Gln Asp Ser 
        435                 440                 445             


Glu Ser Val Leu Leu Val Asp Glu Ala Gly Gly Ser Gly Arg Ala Gly 
    450                 455                 460                 


Pro Ala Pro Lys Gly Ser Ser Leu Gln Val Thr Phe Pro Ser Glu Thr 
465                 470                 475                 480 


Leu Asn Leu Ser Glu Lys Cys Ile 
                485             


<210>  879
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  879

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  880
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  880

Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu 
1               5                   10                  15      


Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr 
            20                  25                  30          


Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu 
        35                  40                  45              


Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu 
    50                  55                  60                  


Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser 
65                  70                  75                  80  


Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln 
                85                  90                  95      


Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr 
            100                 105                 110         


Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser 
        115                 120                 125             


Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser 
    130                 135                 140                 


Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg 
145                 150                 155                 160 


Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val 
                165                 170                 175     


Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala 
            180                 185                 190         


Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln 
        195                 200                 205             


Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu 
    210                 215                 220                 


Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys 
225                 230                 235                 240 


Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr 
                245                 250                 255     


Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr 
            260                 265                 270         


Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys 
        275                 280                 285             


Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe 
    290                 295                 300                 


Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val 
305                 310                 315                 320 


Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser 
                325                 330                 335     


Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met 
            340                 345                 350         


Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser 
        355                 360                 365             


Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr 
    370                 375                 380                 


Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr 
385                 390                 395                 400 


Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly 
                405                 410                 415     


Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys 
            420                 425                 430         


Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu 
        435                 440                 445             


Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp 
    450                 455                 460                 


Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp 
465                 470                 475                 480 


Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe 
                485                 490                 495     


Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg 
            500                 505                 510         


Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val 
        515                 520                 525             


Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly 
    530                 535                 540                 


Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu 
545                 550                 555                 560 


Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro 
                565                 570                 575     


Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe 
            580                 585                 590         


His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile 
        595                 600                 605             


Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His 
    610                 615                 620                 


Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe 
625                 630                 635                 640 


Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu 
                645                 650                 655     


Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met 
            660                 665                 670         


Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp 
        675                 680                 685             


Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys 
    690                 695                 700 


<210>  881
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  881

Met Asn His Asp Phe Gln Ala Leu Ala Leu Glu Ser Arg Gly Met Gly 
1               5                   10                  15      


Glu Leu Leu Pro Thr Lys Lys Phe Trp Glu Pro Asp Asp Ser Thr Lys 
            20                  25                  30          


Asp Gly Gln Lys Gly Ile Phe Leu Gly Asp Asp Glu Trp Arg Glu Thr 
        35                  40                  45              


Ala Trp Gly Ala Ser His His Ser Met Ser Gln Pro Ile Met Val Gln 
    50                  55                  60                  


Arg Arg Ser Gly Gln Gly Phe His Gly Asn Ser Glu Val Asn Ala Ile 
65                  70                  75                  80  


Leu Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu 
                85                  90                  95      


Tyr Val Leu Ser Ser Ser Pro Ala Asp Lys Leu Asp Ser Arg Phe Arg 
            100                 105                 110         


Lys Gly Asn Phe Gly Thr Arg Asp Ala Glu Thr Asp Gly Pro Glu Lys 
        115                 120                 125             


Gly Asp Gln Lys Gly Lys Ala Ser Pro Phe Glu Glu Asp Gln Asn Arg 
    130                 135                 140                 


Asp Leu Lys Gln Gly Asp Asp Asp Asp Ser Lys Ile Asn Gly Arg Gly 
145                 150                 155                 160 


Leu Pro Asn Gly Met Asp Ala Asp Cys Lys Asp Phe Asn Arg Thr Pro 
                165                 170                 175     


Gly Ser Arg Gln Ala Ser Pro Thr Glu Val Val Glu Arg Leu Gly Pro 
            180                 185                 190         


Asn Thr Asn Pro Ser Glu Gly Leu Gly Pro Leu Pro Asn Pro Thr Ala 
        195                 200                 205             


Asn Lys Pro Leu Val Glu Glu Phe Ser Asn Pro Glu Thr Gln Asn Leu 
    210                 215                 220                 


Asp Ala Met Glu Gln Val Gly Leu Glu Ser Leu Gln Phe Asp Tyr Pro 
225                 230                 235                 240 


Gly Asn Gln Val Pro Met Asp Ser Ser Gly Ala Thr Val Gly Leu Phe 
                245                 250                 255     


Asp Tyr Asn Ser Gln Gln Gln Leu Phe Gln Arg Thr Asn Ala Leu Thr 
            260                 265                 270         


Val Gln Gln Leu Thr Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala 
        275                 280                 285             


Ala Gln Gln Pro His Ile Ala Gly Val Phe Ser Ala Gly Leu Ala Pro 
    290                 295                 300                 


Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser Ala Ala Pro Pro Gly 
305                 310                 315                 320 


Thr Asp Pro Tyr Thr Ala Ala Gly Leu Ala Ala Ala Ala Thr Leu Ala 
                325                 330                 335     


Gly Pro Ala Val Val Pro Pro Gln Tyr Tyr Gly Val Pro Trp Gly Val 
            340                 345                 350         


Tyr Pro Ala Asn Leu Phe Gln Gln Gln Ala Ala Ala Ala Ala Asn Asn 
        355                 360                 365             


Thr Ala Ser Gln Gln Ala Ala Ser Gln Ala Gln Pro Gly Gln Gln Gln 
    370                 375                 380                 


Val Leu Arg Ala Gly Ala Gly Gln Arg Pro Leu Thr Pro Asn Gln Gly 
385                 390                 395                 400 


Gln Gln Gly Gln Gln Ala Glu Ser Leu Ala Ala Ala Ala Ala Ala Asn 
                405                 410                 415     


Pro Thr Leu Ala Phe Gly Gln Gly Leu Ala Thr Gly Met Pro Gly Tyr 
            420                 425                 430         


Gln Val Leu Ala Pro Thr Ala Tyr Tyr Asp Gln Thr Gly Ala Leu Val 
        435                 440                 445             


Val Gly Pro Gly Ala Arg Thr Gly Leu Gly Ala Pro Val Arg Leu Met 
    450                 455                 460                 


Ala Pro Thr Pro Val Leu Ile Ser Ser Ala Ala Ala Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Gly Gly Thr Ala Ser Ser Leu Thr Gly Ser Thr Asn 
                485                 490                 495     


Gly Leu Phe Arg Pro Ile Gly Thr Gln Pro Pro Gln Gln Gln Gln Gln 
            500                 505                 510         


Gln Pro Ser Thr Asn Leu Gln Ser Asn Ser Phe Tyr Gly Ser Ser Ser 
        515                 520                 525             


Leu Thr Asn Ser Ser Gln Ser Ser Ser Leu Phe Ser His Gly Pro Gly 
    530                 535                 540                 


Gln Pro Gly Ser Thr Ser Leu Gly Phe Gly Ser Gly Asn Ser Leu Gly 
545                 550                 555                 560 


Ala Ala Ile Gly Ser Ala Leu Ser Gly Phe Gly Ser Ser Val Gly Ser 
                565                 570                 575     


Ser Ala Ser Ser Ser Ala Thr Arg Arg Glu Ser Leu Ser Thr Ser Ser 
            580                 585                 590         


Asp Leu Tyr Lys Arg Ser Ser Ser Ser Leu Ala Pro Ile Gly Gln Pro 
        595                 600                 605             


Phe Tyr Asn Ser Leu Gly Phe Ser Ser Ser Pro Ser Pro Ile Gly Met 
    610                 615                 620                 


Pro Leu Pro Ser Gln Thr Pro Gly His Ser Leu Thr Pro Pro Pro Ser 
625                 630                 635                 640 


Leu Ser Ser His Gly Ser Ser Ser Ser Leu His Leu Gly Gly Leu Thr 
                645                 650                 655     


Asn Gly Ser Gly Arg Tyr Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys 
            660                 665                 670         


Tyr Arg Ser Ala Ser Ser Thr Ser Ser Leu Phe Ser Ser Ser Ser Gln 
        675                 680                 685             


Leu Phe Pro Pro Ser Arg Leu Arg Tyr Asn Arg Ser Asp Ile Met Pro 
    690                 695                 700                 


Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Phe Pro 
705                 710                 715                 720 


Asn Leu Gln Leu Arg Asp Leu Ile Gly His Ile Val Glu Phe Ser Gln 
                725                 730                 735     


Asp Gln His Gly Ser Arg Phe Ile Gln Gln Lys Leu Glu Arg Ala Thr 
            740                 745                 750         


Pro Ala Glu Arg Gln Met Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr 
        755                 760                 765             


Gln Leu Met Thr Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe 
    770                 775                 780                 


Glu Phe Gly Ser Leu Asp Gln Lys Leu Ala Leu Ala Thr Arg Ile Arg 
785                 790                 795                 800 


Gly His Val Leu Pro Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile 
                805                 810                 815     


Gln Lys Ala Leu Glu Ser Ile Ser Ser Asp Gln Gln Ser Glu Met Val 
            820                 825                 830         


Lys Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly 
        835                 840                 845             


Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu 
    850                 855                 860                 


Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Val Leu Ser Thr 
865                 870                 875                 880 


His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Thr 
                885                 890                 895     


Ala Glu Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu 
            900                 905                 910         


Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu 
        915                 920                 925             


Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ser Glu Ile Arg 
    930                 935                 940                 


Gly Lys Val Leu Ala Leu Ser Gln His Lys Phe Ala Ser Asn Val Val 
945                 950                 955                 960 


Glu Lys Cys Val Thr His Ala Ser Arg Ala Glu Arg Ala Leu Leu Ile 
                965                 970                 975     


Asp Glu Val Cys Cys Gln Asn Asp Gly Pro His Ser Ala Leu Tyr Thr 
            980                 985                 990         


Met Met Lys Asp Gln Tyr Ala Asn  Tyr Val Val Gln Lys  Met Ile Asp 
        995                 1000                 1005             


Met Ala  Glu Pro Ala Gln Arg  Lys Ile Ile Met His  Lys Ile Arg 
    1010                 1015                 1020             


Pro His  Ile Thr Thr Leu Arg  Lys Tyr Thr Tyr Gly  Lys His Ile 
    1025                 1030                 1035             


Leu Ala  Lys Leu Glu Lys Tyr  Tyr Leu Lys Asn Ser  Pro Asp Leu 
    1040                 1045                 1050             


Gly Pro  Ile Gly Gly Pro Pro  Asn Gly Met Leu 
    1055                 1060                 


<210>  882
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  882

Met Ser Asn Ser Asn Thr Thr Gln Glu Thr Leu Glu Ile Met Lys Glu 
1               5                   10                  15      


Ser Glu Lys Lys Leu Val Glu Glu Ser Val Asn Lys Asn Lys Phe Ile 
            20                  25                  30          


Ser Lys Thr Pro Ser Lys Glu Glu Ile Glu Lys Glu Cys Glu Asp Thr 
        35                  40                  45              


Ser Leu Arg Gln Glu Thr Gln Arg Arg Thr Ser Asn His Gly His Ala 
    50                  55                  60                  


Arg Lys Arg Ala Lys Ser Asn Ser Lys Leu Lys Leu Val Arg Ser Leu 
65                  70                  75                  80  


Ala Val Cys Glu Glu Ser Ser Thr Pro Phe Ala Asp Gly Pro Leu Glu 
                85                  90                  95      


Thr Gln Asp Ile Ile Gln Leu His Ile Ser Cys Pro Ser Asp Lys Glu 
            100                 105                 110         


Glu Glu Lys Ser Thr Lys Asp Val Ser Glu Lys Glu Asp Lys Asp Lys 
        115                 120                 125             


Asn Lys Glu Lys Ile Pro Arg Lys Met Leu Ser Arg Asp Ser Ser Gln 
    130                 135                 140                 


Glu Tyr Thr Asp Ser Thr Gly Ile Asp Leu His Glu Phe Leu Val Asn 
145                 150                 155                 160 


Thr Leu Lys Lys Asn Pro Arg Asp Arg Met Met Leu Leu Lys Leu Glu 
                165                 170                 175     


Gln Glu Ile Leu Glu Phe Ile Asn Asp Asn Asn Asn Gln Phe Lys Lys 
            180                 185                 190         


Phe Pro Gln Met Thr Ser Tyr His Arg Met Leu Leu His Arg Val Ala 
        195                 200                 205             


Ala Tyr Phe Gly Met Asp His Asn Val Asp Gln Thr Gly Lys Ala Val 
    210                 215                 220                 


Ile Ile Asn Lys Thr Ser Asn Thr Arg Ile Pro Glu Gln Arg Phe Ser 
225                 230                 235                 240 


Glu His Ile Lys Asp Glu Lys Asn Thr Glu Phe Gln Gln Arg Phe Ile 
                245                 250                 255     


Leu Lys Arg Asp Asp Ala Ser Met Asp Arg Asp Asp Asn Gln Thr Gly 
            260                 265                 270         


Gln Asn Gly Tyr Leu Asn Asp Ile Arg Leu Ser Lys Glu Ala Phe Ser 
        275                 280                 285             


Ser Ser Ser His Lys Arg Arg Gln Ile Phe Arg Gly Asn Arg Glu Gly 
    290                 295                 300                 


Leu Ser Arg Thr Ser Ser Ser Arg Gln Ser Ser Thr Asp Ser Glu Leu 
305                 310                 315                 320 


Lys Ser Leu Glu Pro Arg Pro Trp Ser Ser Thr Asp Ser Asp Gly Ser 
                325                 330                 335     


Val Arg Ser Met Arg Pro Pro Val Thr Lys Ala Ser Ser Phe Ser Gly 
            340                 345                 350         


Ile Ser Ile Leu Thr Arg Gly Asp Ser Ile Gly Ser Ser Lys Gly Gly 
        355                 360                 365             


Ser Ala Gly Arg Ile Ser Arg Pro Gly Met Ala Leu Gly Ala Pro Glu 
    370                 375                 380                 


Val Cys Asn Gln Val Thr Ser Ser Gln Ser Val Arg Gly Leu Leu Pro 
385                 390                 395                 400 


Cys Thr Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Pro Ala 
                405                 410                 415     


Leu Pro Pro Thr Pro Gln Gln Gln Pro Pro Leu Asn Asn His Met Ile 
            420                 425                 430         


Ser Gln Ala Asp Asp Leu Ser Asn Pro Phe Gly Gln Met Ser Leu Ser 
        435                 440                 445             


Arg Gln Gly Ser Thr Glu Ala Ala Asp Pro Ser Ala Ala Leu Phe Gln 
    450                 455                 460                 


Thr Pro Leu Ile Ser Gln His Pro Gln Gln Thr Ser Phe Ile Met Ala 
465                 470                 475                 480 


Ser Thr Gly Gln Pro Leu Pro Thr Ser Asn Tyr Ser Thr Ser Ser His 
                485                 490                 495     


Ala Pro Pro Thr Gln Gln Val Leu Pro Pro Gln Gly Tyr Met Gln Pro 
            500                 505                 510         


Pro Gln Gln Ile Gln Val Ser Tyr Tyr Pro Pro Gly Gln Tyr Pro Asn 
        515                 520                 525             


Ser Asn Gln Gln Tyr Arg Pro Leu Ser His Pro Val Ala Tyr Ser Pro 
    530                 535                 540                 


Gln Arg Gly Gln Gln Leu Pro Gln Pro Ser Gln Gln Pro Gly Leu Gln 
545                 550                 555                 560 


Pro Met Met Pro Asn Gln Gln Gln Ala Ala Tyr Gln Gly Met Ile Gly 
                565                 570                 575     


Val Gln Gln Pro Gln Asn Gln Gly Leu Leu Ser Ser Gln Arg Ser Ser 
            580                 585                 590         


Met Gly Gly Gln Met Gln Gly Leu Val Val Gln Tyr Thr Pro Leu Pro 
        595                 600                 605             


Ser Tyr Gln Val Pro Val Gly Ser Asp Ser Gln Asn Val Val Gln Pro 
    610                 615                 620                 


Pro Phe Gln Gln Pro Met Leu Val Pro Val Ser Gln Ser Val Gln Gly 
625                 630                 635                 640 


Gly Leu Pro Ala Ala Gly Val Pro Val Tyr Tyr Ser Met Ile Pro Pro 
                645                 650                 655     


Ala Gln Gln Asn Gly Thr Ser Pro Ser Val Gly Phe Leu Gln Pro Pro 
            660                 665                 670         


Gly Ser Glu Gln Tyr Gln Met Pro Gln Ser Pro Ser Pro Cys Ser Pro 
        675                 680                 685             


Pro Gln Met Pro Gln Gln Tyr Ser Gly Val Ser Pro Ser Gly Pro Gly 
    690                 695                 700                 


Val Val Val Met Gln Leu Asn Val Pro Asn Gly Pro Gln Pro Pro Gln 
705                 710                 715                 720 


Asn Pro Ser Met Val Gln Trp Ser His Cys Lys Tyr Tyr Ser Met Asp 
                725                 730                 735     


Gln Arg Gly Gln Lys Pro Gly Asp Leu Tyr Ser Pro Asp Ser Ser Pro 
            740                 745                 750         


Gln Ala Asn Thr Gln Met Ser Ser Ser Pro Val Thr Ser Pro Thr Gln 
        755                 760                 765             


Ser Pro Ala Pro Ser Pro Val Thr Ser Leu Ser Ser Val Cys Thr Gly 
    770                 775                 780                 


Leu Ser Pro Leu Pro Val Leu Thr Gln Phe Pro Arg Pro Gly Gly Pro 
785                 790                 795                 800 


Ala Gln Gly Asp Gly Arg Tyr Ser Leu Leu Gly Gln Pro Leu Gln Tyr 
                805                 810                 815     


Asn Leu Ser Ile Cys Pro Pro Leu Leu His Gly Gln Ser Thr Tyr Thr 
            820                 825                 830         


Val His Gln Gly Gln Ser Gly Leu Lys His Gly Asn Arg Gly Lys Arg 
        835                 840                 845             


Gln Ala Leu Lys Ser Ala Ser Thr Asp Leu Gly Thr Ala Asp Val Val 
    850                 855                 860                 


Leu Gly Arg Val Leu Glu Val Thr Asp Leu Pro Glu Gly Ile Thr Arg 
865                 870                 875                 880 


Thr Glu Ala Asp Lys Leu Phe Thr Gln Leu Ala Met Ser Gly Ala Lys 
                885                 890                 895     


Ile Gln Trp Leu Lys Asp Ala Gln Gly Leu Pro Gly Gly Gly Gly Gly 
            900                 905                 910         


Asp Asn Ser Gly Thr Ala Glu Asn Gly Arg His Ser Asp Leu Ala Ala 
        915                 920                 925             


Leu Tyr Thr Ile Val Ala Val Phe Pro Ser Pro Leu Ala Ala Gln Asn 
    930                 935                 940                 


Ala Ser Leu Arg Leu Asn Asn Ser Val Ser Arg Phe Lys Leu Arg Met 
945                 950                 955                 960 


Ala Lys Lys Asn Tyr Asp Leu Arg Ile Leu Glu Arg Ala Ser Ser Gln 
                965                 970                 975     


<210>  883
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  883

Met Ser Leu Met Val Ser Ala Gly Arg Gly Leu Gly Ala Val Trp Ser 
1               5                   10                  15      


Pro Thr His Val Gln Val Thr Val Leu Gln Ala Arg Gly Leu Arg Ala 
            20                  25                  30          


Lys Gly Pro Gly Gly Thr Ser Asp Ala Tyr Ala Val Ile Gln Val Gly 
        35                  40                  45              


Lys Glu Lys Tyr Ala Thr Ser Val Ser Glu Arg Ser Leu Gly Ala Pro 
    50                  55                  60                  


Val Trp Arg Glu Glu Ala Thr Phe Glu Leu Pro Ser Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Pro Ala Ala Ala Ala Thr Leu Gln Leu Thr Val Leu His Arg Ala 
                85                  90                  95      


Leu Leu Gly Leu Asp Lys Phe Leu Gly Arg Ala Glu Val Asp Leu Arg 
            100                 105                 110         


Asp Leu His Arg Asp Gln Gly Arg Arg Lys Thr Gln Trp Tyr Lys Leu 
        115                 120                 125             


Lys Ser Lys Pro Gly Lys Lys Asp Lys Glu Arg Gly Glu Ile Glu Val 
    130                 135                 140                 


Asp Ile Gln Phe Met Arg Asn Asn Met Thr Ala Ser Met Phe Asp Leu 
145                 150                 155                 160 


Ser Met Lys Asp Lys Ser Arg Asn Pro Phe Gly Lys Leu Lys Asp Lys 
                165                 170                 175     


Ile Lys Gly Lys Asn Lys Asp Ser Gly Ser Asp Thr Ala Ser Ala Ile 
            180                 185                 190         


Ile Pro Ser Thr Thr Pro Ser Val Asp Ser Asp Asp Glu Ser Val Val 
        195                 200                 205             


Lys Asp Lys Lys Lys Lys Ser Lys Ile Lys Thr Leu Leu Ser Lys Ser 
    210                 215                 220                 


Asn Leu Gln Lys Thr Pro Leu Ser Gln Ser Met Ser Val Leu Pro Thr 
225                 230                 235                 240 


Ser Lys Pro Glu Lys Val Leu Leu Arg Pro Gly Asp Phe Gln Ser Gln 
                245                 250                 255     


Trp Asp Glu Asp Asp Asn Glu Asp Glu Ser Ser Ser Ala Ser Asp Val 
            260                 265                 270         


Met Ser His Lys Arg Thr Ala Ser Thr Asp Leu Lys Gln Leu Asn Gln 
        275                 280                 285             


Val Asn Phe Thr Leu Pro Lys Lys Glu Gly Leu Ser Phe Leu Gly Gly 
    290                 295                 300                 


Leu Arg Ser Lys Asn Asp Val Leu Ser Arg Ser Asn Val Cys Ile Asn 
305                 310                 315                 320 


Gly Asn His Val Tyr Leu Glu Gln Pro Glu Ala Lys Gly Glu Ile Lys 
                325                 330                 335     


Asp Ser Ser Pro Ser Ser Ser Pro Ser Pro Lys Gly Phe Arg Lys Lys 
            340                 345                 350         


His Leu Phe Ser Ser Thr Glu Asn Leu Ala Ala Gly Ser Trp Lys Glu 
        355                 360                 365             


Pro Ala Glu Gly Gly Gly Leu Ser Ser Asp Arg Gln Leu Ser Glu Ser 
    370                 375                 380                 


Ser Thr Lys Asp Ser Leu Lys Ser Met Thr Leu Pro Ser Tyr Arg Pro 
385                 390                 395                 400 


Ala Pro Leu Val Ser Gly Asp Leu Arg Glu Asn Met Ala Pro Ala Asn 
                405                 410                 415     


Ser Glu Ala Thr Lys Glu Ala Lys Glu Ser Lys Lys Pro Glu Ser Arg 
            420                 425                 430         


Arg Ser Ser Leu Leu Ser Leu Met Thr Gly Lys Lys Asp Val Ala Lys 
        435                 440                 445             


Gly Ser Glu Gly Glu Asn Pro Leu Thr Val Pro Gly Arg Glu Lys Glu 
    450                 455                 460                 


Gly Met Leu Met Gly Val Lys Pro Gly Glu Asp Ala Ser Gly Pro Ala 
465                 470                 475                 480 


Glu Asp Leu Val Arg Arg Ser Glu Lys Asp Thr Ala Ala Val Val Ser 
                485                 490                 495     


Arg Gln Gly Ser Ser Leu Asn Leu Phe Glu Asp Val Gln Ile Thr Glu 
            500                 505                 510         


Pro Glu Ala Glu Pro Glu Ser Lys Ser Glu Pro Arg Pro Pro Ile Ser 
        515                 520                 525             


Ser Pro Arg Ala Pro Gln Thr Arg Ala Val Lys Pro Arg Leu His Pro 
    530                 535                 540                 


Val Lys Pro Met Asn Ala Met Ala Thr Lys Val Ala Asn Cys Ser Leu 
545                 550                 555                 560 


Gly Thr Ala Thr Ile Ile Ser Glu Asn Leu Asn Asn Glu Val Met Met 
                565                 570                 575     


Lys Lys Tyr Ser Pro Ser Asp Pro Ala Phe Ala Tyr Ala Gln Leu Thr 
            580                 585                 590         


His Asp Glu Leu Ile Gln Leu Val Leu Lys Gln Lys Glu Thr Ile Ser 
        595                 600                 605             


Lys Lys Glu Phe Gln Val Arg Glu Leu Glu Asp Tyr Ile Asp Asn Leu 
    610                 615                 620                 


Leu Val Arg Val Met Glu Glu Thr Pro Asn Ile Leu Arg Ile Pro Thr 
625                 630                 635                 640 


Gln Val Gly Lys Lys Ala Gly Lys Met 
                645                 


<210>  884
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  884

Met Ala Thr Ala Pro Tyr Asn Tyr Ser Tyr Ile Phe Lys Tyr Ile Ile 
1               5                   10                  15      


Ile Gly Asp Met Gly Val Gly Lys Ser Cys Leu Leu His Gln Phe Thr 
            20                  25                  30          


Glu Lys Lys Phe Met Ala Asp Cys Pro His Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Gly Thr Arg Ile Ile Glu Val Ser Gly Gln Lys Ile Lys Leu Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ala Val Thr Arg Ser Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Ala Gly Ala Leu Met Val Tyr Asp Ile Thr Arg Arg 
                85                  90                  95      


Ser Thr Tyr Asn His Leu Ser Ser Trp Leu Thr Asp Ala Arg Asn Leu 
            100                 105                 110         


Thr Asn Pro Asn Thr Val Ile Ile Leu Ile Gly Asn Lys Ala Asp Leu 
        115                 120                 125             


Glu Ala Gln Arg Asp Val Thr Tyr Glu Glu Ala Lys Gln Phe Ala Glu 
    130                 135                 140                 


Glu Asn Gly Leu Leu Phe Leu Glu Ala Ser Ala Lys Thr Gly Glu Asn 
145                 150                 155                 160 


Val Glu Asp Ala Phe Leu Glu Ala Ala Lys Lys Ile Tyr Gln Asn Ile 
                165                 170                 175     


Gln Asp Gly Ser Leu Asp Leu Asn Ala Ala Glu Ser Gly Val Gln His 
            180                 185                 190         


Lys Pro Ser Ala Pro Gln Gly Gly Arg Leu Thr Ser Glu Pro Gln Pro 
        195                 200                 205             


Gln Arg Glu Gly Cys Gly Cys 
    210                 215 


<210>  885
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  885

Met Met Ala Ile Arg Glu Leu Lys Val Cys Leu Leu Gly Asp Thr Gly 
1               5                   10                  15      


Val Gly Lys Ser Ser Ile Val Cys Arg Phe Val Gln Asp His Phe Asp 
            20                  25                  30          


His Asn Ile Ser Pro Thr Ile Gly Ala Ser Phe Met Thr Lys Thr Val 
        35                  40                  45              


Pro Cys Gly Asn Glu Leu His Lys Phe Leu Ile Trp Asp Thr Ala Gly 
    50                  55                  60                  


Gln Glu Arg Phe His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ser Ala 
65                  70                  75                  80  


Ala Ala Val Ile Val Tyr Asp Ile Thr Lys Gln Asp Ser Phe Tyr Thr 
                85                  90                  95      


Leu Lys Lys Trp Val Lys Glu Leu Lys Glu His Gly Pro Glu Asn Ile 
            100                 105                 110         


Val Met Ala Ile Ala Gly Asn Lys Cys Asp Leu Ser Asp Ile Arg Glu 
        115                 120                 125             


Val Pro Leu Lys Asp Ala Lys Glu Tyr Ala Glu Ser Ile Gly Ala Ile 
    130                 135                 140                 


Val Val Glu Thr Ser Ala Lys Asn Ala Ile Asn Ile Glu Glu Leu Phe 
145                 150                 155                 160 


Gln Gly Ile Ser Arg Gln Ile Pro Pro Leu Asp Pro His Glu Asn Gly 
                165                 170                 175     


Asn Asn Gly Thr Ile Lys Val Glu Lys Pro Thr Met Gln Ala Ser Arg 
            180                 185                 190         


Arg Cys Cys 
        195 


<210>  886
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  886

Met Ala Glu Thr Tyr Asp Phe Leu Phe Lys Phe Leu Val Ile Gly Ser 
1               5                   10                  15      


Ala Gly Thr Gly Lys Ser Cys Leu Leu His Gln Phe Ile Glu Asn Lys 
            20                  25                  30          


Phe Lys Gln Asp Ser Asn His Thr Ile Gly Val Glu Phe Gly Ser Arg 
        35                  40                  45              


Val Val Asn Val Gly Gly Lys Thr Val Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Ser Val Thr Arg Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Ala Gly Ala Leu Leu Val Tyr Asp Ile Thr Ser Arg Glu Thr Tyr 
                85                  90                  95      


Asn Ser Leu Ala Ala Trp Leu Thr Asp Ala Arg Thr Leu Ala Ser Pro 
            100                 105                 110         


Asn Ile Val Val Ile Leu Cys Gly Asn Lys Lys Asp Leu Asp Pro Glu 
        115                 120                 125             


Arg Glu Val Thr Phe Leu Glu Ala Ser Arg Phe Ala Gln Glu Asn Glu 
    130                 135                 140                 


Leu Met Phe Leu Glu Thr Ser Ala Leu Thr Gly Glu Asn Val Glu Glu 
145                 150                 155                 160 


Ala Phe Leu Lys Cys Ala Arg Thr Ile Leu Asn Lys Ile Asp Ser Gly 
                165                 170                 175     


Glu Leu Asp Pro Glu Arg Met Gly Ser Gly Ile Gln Tyr Gly Asp Ala 
            180                 185                 190         


Ser Leu Arg Gln Leu Arg Gln Pro Arg Ser Ala Gln Ala Val Ala Pro 
        195                 200                 205             


Gln Pro Cys Gly Cys 
    210             


<210>  887
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  887

Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
            20                  25                  30          


Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
        35                  40                  45              


Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
65                  70                  75                  80  


Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                85                  90                  95      


Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
            100                 105                 110         


Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
        115                 120                 125             


Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
    130                 135                 140                 


Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
145                 150                 155                 160 


Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                165                 170                 175     


Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
            180                 185                 190         


Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
        195                 200                 205         


<210>  888
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  888

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
1               5                   10                  15      


Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
            20                  25                  30          


Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
        35                  40                  45              


Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
    50                  55                  60                  


Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
65                  70                  75                  80  


Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                85                  90                  95      


Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
            100                 105                 110         


Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
        115                 120                 125             


Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
    130                 135                 140                 


Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
145                 150                 155                 160 


Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                165                 170                 175     


Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
            180                 185                 190         


Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 
        195                 200                 205             


Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
    210                 215                 220                 


Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
225                 230                 235                 240 


Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                245                 250                 255     


Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
            260                 265                 270         


Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
        275                 280                 285             


Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
    290                 295                 300                 


Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
305                 310                 315                 320 


Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                325                 330                 335     


Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
            340                 345                 350         


Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
        355                 360                 365             


His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
    370                 375                 380                 


Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
385                 390                 395                 400 


Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                405                 410                 415     


Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
            420                 425                 430         


Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
        435                 440                 445             


Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
    450                 455                 460                 


Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
465                 470                 475                 480 


Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                485                 490                 495     


Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
            500                 505                 510         


Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
        515                 520                 525             


Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
    530                 535                 540                 


Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
545                 550                 555                 560 


Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 
                565                 570                 575     


Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
            580                 585                 590         


Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
        595                 600                 605             


Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
    610                 615                 620                 


Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
625                 630                 635                 640 


Thr Ser Pro Arg Leu Pro Val Phe 
                645             


<210>  889
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  889

Met Ala Ala Asn Lys Ser Lys Gly Gln Ser Ser Leu Ala Leu His Lys 
1               5                   10                  15      


Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
            20                  25                  30          


Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
        35                  40                  45              


Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
65                  70                  75                  80  


Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                85                  90                  95      


Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
        115                 120                 125             


Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
    130                 135                 140                 


Ser Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                165                 170                 175     


Arg Thr Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Lys Lys Ser 
            180                 185                 190         


Ser Lys Asn Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
        195                 200                 205     


<210>  890
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  890

Met Ala Ser Asn Ser Ser Ser Cys Pro Thr Pro Gly Gly Gly His Leu 
1               5                   10                  15      


Asn Gly Tyr Pro Val Pro Pro Tyr Ala Phe Phe Phe Pro Pro Met Leu 
            20                  25                  30          


Gly Gly Leu Ser Pro Pro Gly Ala Leu Thr Thr Leu Gln His Gln Leu 
        35                  40                  45              


Pro Val Ser Gly Tyr Ser Thr Pro Ser Pro Ala Thr Ile Glu Thr Gln 
    50                  55                  60                  


Ser Ser Ser Ser Glu Glu Ile Val Pro Ser Pro Pro Ser Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Arg Ile Tyr Lys Pro Cys Phe Val Cys Gln Asp Lys Ser Ser 
                85                  90                  95      


Gly Tyr His Tyr Gly Val Ser Ala Cys Glu Gly Cys Lys Gly Phe Phe 
            100                 105                 110         


Arg Arg Ser Ile Gln Lys Asn Met Val Tyr Thr Cys His Arg Asp Lys 
        115                 120                 125             


Asn Cys Ile Ile Asn Lys Val Thr Arg Asn Arg Cys Gln Tyr Cys Arg 
    130                 135                 140                 


Leu Gln Lys Cys Phe Glu Val Gly Met Ser Lys Glu Ser Val Arg Asn 
145                 150                 155                 160 


Asp Arg Asn Lys Lys Lys Lys Glu Val Pro Lys Pro Glu Cys Ser Glu 
                165                 170                 175     


Ser Tyr Thr Leu Thr Pro Glu Val Gly Glu Leu Ile Glu Lys Val Arg 
            180                 185                 190         


Lys Ala His Gln Glu Thr Phe Pro Ala Leu Cys Gln Leu Gly Lys Tyr 
        195                 200                 205             


Thr Thr Asn Asn Ser Ser Glu Gln Arg Val Ser Leu Asp Ile Asp Leu 
    210                 215                 220                 


Trp Asp Lys Phe Ser Glu Leu Ser Thr Lys Cys Ile Ile Lys Thr Val 
225                 230                 235                 240 


Glu Phe Ala Lys Gln Leu Pro Gly Phe Thr Thr Leu Thr Ile Ala Asp 
                245                 250                 255     


Gln Ile Thr Leu Leu Lys Ala Ala Cys Leu Asp Ile Leu Ile Leu Arg 
            260                 265                 270         


Ile Cys Thr Arg Tyr Thr Pro Glu Gln Asp Thr Met Thr Phe Ser Asp 
        275                 280                 285             


Gly Leu Thr Leu Asn Arg Thr Gln Met His Asn Ala Gly Phe Gly Pro 
    290                 295                 300                 


Leu Thr Asp Leu Val Phe Ala Phe Ala Asn Gln Leu Leu Pro Leu Glu 
305                 310                 315                 320 


Met Asp Asp Ala Glu Thr Gly Leu Leu Ser Ala Ile Cys Leu Ile Cys 
                325                 330                 335     


Gly Asp Arg Gln Asp Leu Glu Gln Pro Asp Arg Val Asp Met Leu Gln 
            340                 345                 350         


Glu Pro Leu Leu Glu Ala Leu Lys Val Tyr Val Arg Lys Arg Arg Pro 
        355                 360                 365             


Ser Arg Pro His Met Phe Pro Lys Met Leu Met Lys Ile Thr Asp Leu 
    370                 375                 380                 


Arg Ser Ile Ser Ala Lys Gly Ala Glu Arg Val Ile Thr Leu Lys Met 
385                 390                 395                 400 


Glu Ile Pro Gly Ser Met Pro Pro Leu Ile Gln Glu Met Leu Glu Asn 
                405                 410                 415     


Ser Glu Gly Leu Asp Thr Leu Ser Gly Gln Pro Gly Gly Gly Gly Arg 
            420                 425                 430         


Asp Gly Gly Gly Leu Ala Pro Pro Pro Gly Ser Cys Ser Pro Ser Leu 
        435                 440                 445             


Ser Pro Ser Ser Asn Arg Ser Ser Pro Ala Thr His Ser Pro 
    450                 455                 460         


<210>  891
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  891

Met Asp Tyr Ser His Gln Thr Ser Leu Val Pro Cys Gly Gln Asp Lys 
1               5                   10                  15      


Tyr Ile Ser Lys Asn Glu Leu Leu Leu His Leu Lys Thr Tyr Asn Leu 
            20                  25                  30          


Tyr Tyr Glu Gly Gln Asn Leu Gln Leu Arg His Arg Glu Glu Glu Asp 
        35                  40                  45              


Glu Phe Ile Val Glu Gly Leu Leu Asn Ile Ser Trp Gly Leu Arg Arg 
    50                  55                  60                  


Pro Ile Arg Leu Gln Met Gln Asp Asp Asn Glu Arg Ile Arg Pro Pro 
65                  70                  75                  80  


Pro Ser Ser Ser Ser Trp His Ser Gly Cys Asn Leu Gly Ala Gln Gly 
                85                  90                  95      


Thr Thr Leu Lys Pro Leu Thr Val Pro Lys Val Gln Ile Ser Glu Val 
            100                 105                 110         


Asp Ala Pro Pro Glu Gly Asp Gln Met Pro Ser Ser Thr Asp Ser Arg 
        115                 120                 125             


Gly Leu Lys Pro Leu Gln Glu Asp Thr Pro Gln Leu Met Arg Thr Arg 
    130                 135                 140                 


Ser Asp Val Gly Val Arg Arg Arg Gly Asn Val Arg Thr Pro Ser Asp 
145                 150                 155                 160 


Gln Arg Arg Ile Arg Arg His Arg Phe Ser Ile Asn Gly His Phe Tyr 
                165                 170                 175     


Asn His Lys Thr Ser Val Phe Thr Pro Ala Tyr Gly Ser Val Thr Asn 
            180                 185                 190         


Val Arg Ile Asn Ser Thr Met Thr Thr Pro Gln Val Leu Lys Leu Leu 
        195                 200                 205             


Leu Asn Lys Phe Lys Ile Glu Asn Ser Ala Glu Glu Phe Ala Leu Tyr 
    210                 215                 220                 


Val Val His Thr Ser Gly Glu Lys Gln Lys Leu Lys Ala Thr Asp Tyr 
225                 230                 235                 240 


Pro Leu Ile Ala Arg Ile Leu Gln Gly Pro Cys Glu Gln Ile Ser Lys 
                245                 250                 255     


Val Phe Leu Met Glu Lys Asp Gln Val Glu Glu Val Thr Tyr Asp Val 
            260                 265                 270         


Ala Gln Tyr Ile Lys Phe Glu Met Pro Val Leu Lys Ser Phe Ile Gln 
        275                 280                 285             


Lys Leu Gln Glu Glu Glu Asp Arg Glu Val Lys Lys Leu Met Arg Lys 
    290                 295                 300                 


Tyr Thr Val Leu Arg Leu Met Ile Arg Gln Arg Leu Glu Glu Ile Ala 
305                 310                 315                 320 


Glu Thr Pro Ala Thr Ile 
                325     


<210>  892
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  892

Met Ala Ser Asp Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala 
1               5                   10                  15      


Pro Tyr Lys Lys Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys 
            20                  25                  30          


Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu 
        35                  40                  45              


Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Asn Arg Ser Arg Asp 
    50                  55                  60                  


Arg Asp Arg Tyr Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg 
65                  70                  75                  80  


Gln Cys Arg His Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu 
                85                  90                  95      


Ser Arg Ser Arg Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser 
            100                 105                 110         


Pro Pro Leu Ala Thr Gly Tyr Arg Tyr Gly His Ser Lys Ser Pro His 
        115                 120                 125             


Phe Arg Glu Lys Ser Pro Val Arg Glu Pro Val Asp Asn Leu Ser Pro 
    130                 135                 140                 


Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Pro Arg Asp Leu Glu Asp Phe Phe Ser Ala Val Gly Lys Val 
                165                 170                 175     


Arg Asp Val Arg Ile Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly 
            180                 185                 190         


Ile Ala Tyr Val Glu Phe Cys Glu Ile Gln Ser Val Pro Leu Ala Ile 
        195                 200                 205             


Gly Leu Thr Gly Gln Arg Leu Leu Gly Val Pro Ile Ile Val Gln Ala 
    210                 215                 220                 


Ser Gln Ala Glu Lys Asn Arg Leu Ala Ala Met Ala Asn Asn Leu Gln 
225                 230                 235                 240 


Lys Gly Asn Gly Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe 
                245                 250                 255     


Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys 
            260                 265                 270         


Ile Asp Asn Ile Val Leu Met Lys Asp Ser Asp Thr Gly Arg Ser Lys 
        275                 280                 285             


Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala 
    290                 295                 300                 


Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro Met Arg Val 
305                 310                 315                 320 


Gly His Val Thr Glu Arg Leu Asp Gly Gly Thr Asp Ile Thr Phe Pro 
                325                 330                 335     


Asp Gly Asp Gln Glu Leu Asp Leu Gly Ser Ala Gly Gly Arg Phe Gln 
            340                 345                 350         


Leu Met Ala Lys Leu Ala Glu Gly Ala Gly Ile Gln Leu Pro Ser Thr 
        355                 360                 365             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ala Ala Ala Leu Gln Leu 
    370                 375                 380                 


Asn Gly Ala Val Pro Leu Gly Ala Leu Asn Pro Ala Ala Leu Thr Ala 
385                 390                 395                 400 


Leu Ser Pro Ala Leu Asn Leu Ala Ser Gln Cys Phe Gln Leu Ser Ser 
                405                 410                 415     


Leu Phe Thr Pro Gln Thr Met 
            420             


<210>  893
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  893

Met Gly Lys Val Trp Lys Gln Gln Met Tyr Pro Gln Tyr Ala Thr Tyr 
1               5                   10                  15      


Tyr Tyr Pro Gln Tyr Leu Gln Ala Lys Gln Ser Leu Val Pro Ala His 
            20                  25                  30          


Pro Met Ala Pro Pro Ser Pro Ser Thr Thr Ser Ser Asn Asn Asn Ser 
        35                  40                  45              


Ser Ser Ser Ser Asn Ser Gly Trp Asp Gln Leu Ser Lys Thr Asn Leu 
    50                  55                  60                  


Tyr Ile Arg Gly Leu Pro Pro His Thr Thr Asp Gln Asp Leu Val Lys 
65                  70                  75                  80  


Leu Cys Gln Pro Tyr Gly Lys Ile Val Ser Thr Lys Ala Ile Leu Asp 
                85                  90                  95      


Lys Thr Thr Asn Lys Cys Lys Gly Tyr Gly Phe Val Asp Phe Asp Ser 
            100                 105                 110         


Pro Ala Ala Ala Gln Lys Ala Val Ser Ala Leu Lys Ala Ser Gly Val 
        115                 120                 125             


Gln Ala Gln Met Ala Lys Gln Gln Glu Gln Asp Pro Thr Asn Leu Tyr 
    130                 135                 140                 


Ile Ser Asn Leu Pro Leu Ser Met Asp Glu Gln Glu Leu Glu Asn Met 
145                 150                 155                 160 


Leu Lys Pro Phe Gly Gln Val Ile Ser Thr Arg Ile Leu Arg Asp Ser 
                165                 170                 175     


Ser Gly Thr Ser Arg Gly Val Gly Phe Ala Arg Met Glu Ser Thr Glu 
            180                 185                 190         


Lys Cys Glu Ala Val Ile Gly His Phe Asn Gly Lys Phe Ile Lys Thr 
        195                 200                 205             


Pro Pro Gly Val Ser Ala Pro Thr Glu Pro Leu Leu Cys Lys Phe Ala 
    210                 215                 220                 


Asp Gly Gly Gln Lys Lys Arg Gln Asn Pro Asn Lys Tyr Ile Pro Asn 
225                 230                 235                 240 


Gly Arg Pro Trp His Arg Glu Gly Glu Val Arg Leu Ala Gly Met Thr 
                245                 250                 255     


Leu Thr Tyr Asp Pro Thr Thr Ala Ala Ile Gln Asn Gly Phe Tyr Pro 
            260                 265                 270         


Ser Pro Tyr Ser Ile Ala Thr Asn Arg Met Ile Thr Gln Thr Ser Ile 
        275                 280                 285             


Thr Pro Tyr Ile Ala Ser Pro Val Ser Ala Tyr Gln Val Gln Ser Pro 
    290                 295                 300                 


Ser Trp Met Gln Pro Gln Pro Tyr Ile Leu Gln His Pro Gly Ala Val 
305                 310                 315                 320 


Leu Thr Pro Ser Met Glu His Thr Met Ser Leu Gln Pro Ala Ser Met 
                325                 330                 335     


Ile Ser Pro Leu Ala Gln Gln Met Ser His Leu Ser Leu Gly Ser Thr 
            340                 345                 350         


Gly Thr Tyr Met Pro Ala Thr Ser Ala Met Gln Gly Ala Tyr Leu Pro 
        355                 360                 365             


Gln Tyr Ala His Met Gln Thr Thr Ala Val Pro Val Glu Glu Ala Ser 
    370                 375                 380                 


Gly Gln Gln Gln Val Ala Val Glu Thr Ser Asn Asp His Ser Pro Tyr 
385                 390                 395                 400 


Thr Phe Gln Pro Asn Lys 
                405     


<210>  894
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  894

Met Pro Val Gln Ala Ala Gln Trp Thr Glu Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Tyr Asn Glu Phe Asp Glu Asn Val His Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Ser His Thr Val Cys Lys Thr Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Ala Ile Asn Thr Asp Ile Asp Val Leu 
    50                  55                  60                  


Pro Val Asn Phe Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Asp 
65                  70                  75                  80  


His Gln Ser Ile Lys Leu Ser Asn Leu Gly Glu Asn Lys His Tyr Glu 
                85                  90                  95      


Val Ala Lys Lys Cys Val Glu Asp Leu Ala Leu Tyr Leu Lys Pro Leu 
            100                 105                 110         


Ser Gly Gly Lys Gly Val Ala Ser Leu Asn Gln Ser Ala Leu Ser Arg 
        115                 120                 125             


Pro Met Gln Arg Lys Leu Val Thr Leu Val Asn Cys Gln Leu Val Glu 
    130                 135                 140                 


Glu Glu Gly Arg Val Arg Ala Met Arg Ala Ala Arg Ser Leu Gly Glu 
145                 150                 155                 160 


Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro Gln Gln Leu 
                165                 170                 175     


Ser Ala Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys Gln Phe Leu 
            180                 185                 190         


Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu Leu Ala Leu 
        195                 200                 205             


Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu Phe Val Val 
    210                 215                 220                 


Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr Ser Ile Gly 
225                 230                 235                 240 


His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys Val Thr Lys 
                245                 250                 255     


Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu Phe Arg Ser 
            260                 265                 270         


Tyr Glu Ala Leu Arg Arg Glu His Asp Ala Gln Ile Val His Ile Ala 
        275                 280                 285             


Met Glu Ala Gly Leu Arg Ile Ser Pro Glu Gln Trp Ser Ser Leu Leu 
    290                 295                 300                 


Tyr Gly Asp Leu Ala His Lys Ser His Met Gln Ser Ile Ile Asp Lys 
305                 310                 315                 320 


Leu Gln Ser Pro Glu Ser Phe Ala Lys Ser Val Gln Glu Leu Thr Ile 
                325                 330                 335     


Val Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg Leu Arg Pro 
            340                 345                 350         


His Leu Glu Leu Leu Ala Asn Ile Asp Pro Asn Pro Asp Ala Val Ser 
        355                 360                 365             


Pro Thr Trp Glu Gln Leu Glu Asn Ala Met Val Ala Val Lys Thr Val 
    370                 375                 380                 


Val His Gly Leu Val Asp Phe Ile Gln Asn Tyr Ser Arg Lys Gly His 
385                 390                 395                 400 


Glu Thr Pro Gln Pro Gln Pro Asn Ser Lys Tyr Lys Thr Ser Met Cys 
                405                 410                 415     


Arg Asp Leu Arg Gln Gln Gly Gly Cys Pro Arg Gly Thr Asn Cys Thr 
            420                 425                 430         


Phe Ala His Ser Gln Glu Glu Leu Glu Lys Tyr Arg Leu Arg Asn Lys 
        435                 440                 445             


Lys Ile Asn Ala Thr Val Arg Thr Phe Pro Leu Leu Asn Lys Val Gly 
    450                 455                 460                 


Val Asn Asn Thr Val Thr Thr Thr Ala Gly Asn Val Ile Ser Val Ile 
465                 470                 475                 480 


Gly Ser Thr Glu Thr Thr Gly Lys Ile Val Pro Ser Thr Asn Gly Ile 
                485                 490                 495     


Ser Asn Ala Glu Asn Ser Val Ser Gln Leu Ile Ser Arg Ser Thr Asp 
            500                 505                 510         


Ser Thr Leu Arg Ala Leu Glu Thr Val Lys Lys Val Gly Lys Val Gly 
        515                 520                 525             


Ala Asn Gly Gln Asn Ala Ala Gly Pro Ser Ala Asp Ser Val Thr Glu 
    530                 535                 540                 


Asn Lys Ile Gly Ser Pro Pro Lys Thr Pro Val Ser Asn Val Ala Ala 
545                 550                 555                 560 


Thr Ser Ala Gly Pro Ser Asn Val Gly Thr Glu Leu Asn Ser Val Pro 
                565                 570                 575     


Gln Lys Ser Ser Pro Phe Leu Thr Arg Val Pro Val Tyr Pro Pro His 
            580                 585                 590         


Ser Glu Asn Ile Gln Tyr Phe Gln Asp Pro Arg Thr Gln Ile Pro Phe 
        595                 600                 605             


Glu Val Pro Gln Tyr Pro Gln Thr Gly Tyr Tyr Pro Pro Pro Pro Thr 
    610                 615                 620                 


Val Pro Ala Gly Val Ala Pro Cys Val Pro Arg Phe Val Arg Ser Asn 
625                 630                 635                 640 


Asn Val Pro Glu Ser Ser Leu Pro Pro Ala Ser Met Pro Tyr Ala Asp 
                645                 650                 655     


His Tyr Ser Thr Phe Ser Pro Arg Asp Arg Met Asn Ser Ser Pro Tyr 
            660                 665                 670         


Gln Pro Pro Pro Pro Gln Pro Tyr Gly Pro Val Pro Pro Val Pro Ser 
        675                 680                 685             


Gly Met Tyr Ala Pro Val Tyr Asp Ser Arg Arg Ile Trp Arg Pro Pro 
    690                 695                 700                 


Met Tyr Gln Arg Asp Asp Ile Ile Arg Ser Asn Ser Leu Pro Pro Met 
705                 710                 715                 720 


Asp Val Met His Ser Ser Val Tyr Gln Thr Ser Leu Arg Glu Arg Tyr 
                725                 730                 735     


Asn Ser Leu Asp Gly Tyr Tyr Ser Val Ala Cys Gln Pro Pro Ser Glu 
            740                 745                 750         


Pro Arg Thr Thr Val Pro Leu Pro Arg Glu Pro Cys Gly His Leu Lys 
        755                 760                 765             


Thr Ser Cys Glu Glu Gln Ile Arg Arg Lys Pro Asp Gln Trp Ala Gln 
    770                 775                 780                 


Tyr His Thr Gln Lys Ala Pro Leu Val Ser Ser Thr Leu Pro Val Ala 
785                 790                 795                 800 


Thr Gln Ser Pro Thr Pro Pro Ser Pro Leu Phe Ser Val Asp Phe Arg 
                805                 810                 815     


Ala Asp Phe Ser Glu Ser Val Ser Gly Thr Lys Phe Glu Glu Asp His 
            820                 825                 830         


Leu Ser His Tyr Ser Pro Trp Ser Cys Gly Thr Ile Gly Ser Cys Ile 
        835                 840                 845             


Asn Ala Ile Asp Ser Glu Pro Lys Asp Val Ile Ala Asn Ser Asn Ala 
    850                 855                 860                 


Val Leu Met Asp Leu Asp Ser Gly Asp Val Lys Arg Arg Val His Leu 
865                 870                 875                 880 


Phe Glu Thr Gln Arg Arg Thr Lys Glu Glu Asp Pro Ile Ile Pro Phe 
                885                 890                 895     


Ser Asp Gly Pro Ile Ile Ser Lys Trp Gly Ala Ile Ser Arg Ser Ser 
            900                 905                 910         


Arg Thr Gly Tyr His Thr Thr Asp Pro Val Gln Ala Thr Ala Ser Gln 
        915                 920                 925             


Gly Ser Ala Thr Lys Pro Ile Ser Val Ser Asp Tyr Val Pro Tyr Val 
    930                 935                 940                 


Asn Ala Val Asp Ser Arg Trp Ser Ser Tyr Gly Asn Glu Ala Thr Ser 
945                 950                 955                 960 


Ser Ala His Tyr Val Glu Arg Asp Arg Phe Ile Val Thr Asp Leu Ser 
                965                 970                 975     


Gly His Arg Lys His Ser Ser Thr Gly Asp Leu Leu Ser Leu Glu Leu 
            980                 985                 990         


Gln Gln Ala Lys Ser Asn Ser Leu  Leu Leu Gln Arg Glu  Ala Asn Ala 
        995                 1000                 1005             


Leu Ala  Met Gln Gln Lys Trp  Asn Ser Leu Asp Glu  Gly Arg His 
    1010                 1015                 1020             


Leu Thr  Leu Asn Leu Leu Ser  Lys Glu Ile Glu Leu  Arg Asn Gly 
    1025                 1030                 1035             


Glu Val  Lys Lys Leu Asn Leu  Ser Ala Ser Cys Leu  Met Tyr Leu 
    1040                 1045                 1050             


Phe Ser  Ala Ala Ala Ser Trp  Leu Tyr His Tyr 
    1055                 1060                 


<210>  895
<211>  1566
<212>  PRT
<213>  Homo sapiens

<400>  895

Met Thr Ala Asp Lys Asp Lys Asp Lys Asp Lys Glu Lys Asp Arg Asp 
1               5                   10                  15      


Arg Asp Arg Asp Arg Glu Arg Glu Lys Arg Asp Lys Ala Arg Glu Ser 
            20                  25                  30          


Glu Asn Ser Arg Pro Arg Arg Ser Cys Thr Leu Glu Gly Gly Ala Lys 
        35                  40                  45              


Asn Tyr Ala Glu Ser Asp His Ser Glu Asp Glu Asp Asn Asp Asn Asn 
    50                  55                  60                  


Ser Ala Thr Ala Glu Glu Ser Thr Lys Lys Asn Lys Lys Lys Pro Pro 
65                  70                  75                  80  


Lys Lys Lys Ser Arg Tyr Glu Arg Thr Asp Thr Gly Glu Ile Thr Ser 
                85                  90                  95      


Tyr Ile Thr Glu Asp Asp Val Val Tyr Arg Pro Gly Asp Cys Val Tyr 
            100                 105                 110         


Ile Glu Ser Arg Arg Pro Asn Thr Pro Tyr Phe Ile Cys Ser Ile Gln 
        115                 120                 125             


Asp Phe Lys Leu Val His Asn Ser Gln Ala Cys Cys Arg Ser Pro Thr 
    130                 135                 140                 


Pro Ala Leu Cys Asp Pro Pro Ala Cys Ser Leu Pro Val Ala Ser Gln 
145                 150                 155                 160 


Pro Pro Gln His Leu Ser Glu Ala Gly Arg Gly Pro Val Gly Ser Lys 
                165                 170                 175     


Arg Asp His Leu Leu Met Asn Val Lys Trp Tyr Tyr Arg Gln Ser Glu 
            180                 185                 190         


Val Pro Asp Ser Val Tyr Gln His Leu Val Gln Asp Arg His Asn Glu 
        195                 200                 205             


Asn Asp Ser Gly Arg Glu Leu Val Ile Thr Asp Pro Val Ile Lys Asn 
    210                 215                 220                 


Arg Glu Leu Phe Ile Ser Asp Tyr Val Asp Thr Tyr His Ala Ala Ala 
225                 230                 235                 240 


Leu Arg Gly Lys Cys Asn Ile Ser His Phe Ser Asp Ile Phe Ala Ala 
                245                 250                 255     


Arg Glu Phe Lys Ala Arg Val Asp Ser Phe Phe Tyr Ile Leu Gly Tyr 
            260                 265                 270         


Asn Pro Glu Thr Arg Arg Leu Asn Ser Thr Gln Gly Glu Ile Arg Val 
        275                 280                 285             


Gly Pro Ser His Gln Ala Lys Leu Pro Asp Leu Gln Pro Phe Pro Ser 
    290                 295                 300                 


Pro Asp Gly Asp Thr Val Thr Gln His Glu Glu Leu Val Trp Met Pro 
305                 310                 315                 320 


Gly Val Asn Asp Cys Asp Leu Leu Met Tyr Leu Arg Ala Ala Arg Ser 
                325                 330                 335     


Met Ala Ala Phe Ala Gly Met Cys Asp Gly Gly Ser Thr Glu Asp Gly 
            340                 345                 350         


Cys Val Ala Ala Ser Arg Asp Asp Thr Thr Leu Asn Ala Leu Asn Thr 
        355                 360                 365             


Leu His Glu Ser Gly Tyr Asp Ala Gly Lys Ala Leu Gln Arg Leu Val 
    370                 375                 380                 


Lys Lys Pro Val Pro Lys Leu Ile Glu Lys Cys Trp Thr Glu Asp Glu 
385                 390                 395                 400 


Val Lys Arg Phe Val Lys Gly Leu Arg Gln Tyr Gly Lys Asn Phe Phe 
                405                 410                 415     


Arg Ile Arg Lys Glu Leu Leu Pro Asn Lys Glu Thr Gly Glu Leu Ile 
            420                 425                 430         


Thr Phe Tyr Tyr Tyr Trp Lys Lys Thr Pro Glu Ala Ala Ser Ser Arg 
        435                 440                 445             


Ala His Arg Arg His Arg Arg Gln Ala Val Phe Arg Arg Ile Lys Thr 
    450                 455                 460                 


Arg Thr Ala Ser Thr Pro Val Asn Thr Pro Ser Arg Pro Pro Ser Ser 
465                 470                 475                 480 


Glu Phe Leu Asp Leu Ser Ser Ala Ser Glu Asp Asp Phe Asp Ser Glu 
                485                 490                 495     


Asp Ser Glu Gln Glu Leu Lys Gly Tyr Ala Cys Arg His Cys Phe Thr 
            500                 505                 510         


Thr Thr Ser Lys Asp Trp His His Gly Gly Arg Glu Asn Ile Leu Leu 
        515                 520                 525             


Cys Thr Asp Cys Arg Ile His Phe Lys Lys Tyr Gly Glu Leu Pro Pro 
    530                 535                 540                 


Ile Glu Lys Pro Val Asp Pro Pro Pro Phe Met Phe Lys Pro Val Lys 
545                 550                 555                 560 


Glu Glu Asp Asp Gly Leu Ser Gly Lys His Ser Met Arg Thr Arg Arg 
                565                 570                 575     


Ser Arg Gly Ser Met Ser Thr Leu Arg Ser Gly Arg Lys Lys Gln Pro 
            580                 585                 590         


Ala Ser Pro Asp Gly Arg Thr Ser Pro Ile Asn Glu Asp Ile Arg Ser 
        595                 600                 605             


Ser Gly Arg Asn Ser Pro Ser Ala Ala Ser Thr Ser Ser Asn Asp Ser 
    610                 615                 620                 


Lys Ala Glu Thr Val Lys Lys Ser Ala Lys Lys Val Lys Glu Glu Ala 
625                 630                 635                 640 


Ser Ser Pro Leu Lys Ser Asn Lys Arg Gln Arg Glu Lys Val Ala Ser 
                645                 650                 655     


Asp Thr Glu Glu Ala Asp Arg Thr Ser Ser Lys Lys Thr Lys Thr Gln 
            660                 665                 670         


Glu Ile Ser Arg Pro Asn Ser Pro Ser Glu Gly Glu Gly Glu Ser Ser 
        675                 680                 685             


Asp Ser Arg Ser Val Asn Asp Glu Gly Ser Ser Asp Pro Lys Asp Ile 
    690                 695                 700                 


Asp Gln Asp Asn Arg Ser Thr Ser Pro Ser Ile Pro Ser Pro Gln Asp 
705                 710                 715                 720 


Asn Glu Ser Asp Ser Asp Ser Ser Ala Gln Gln Gln Met Leu Gln Ala 
                725                 730                 735     


Gln Pro Pro Ala Leu Gln Ala Pro Thr Gly Val Thr Pro Ala Pro Ser 
            740                 745                 750         


Ser Ala Pro Pro Gly Thr Pro Gln Leu Pro Thr Pro Gly Pro Thr Pro 
        755                 760                 765             


Ser Ala Thr Ala Val Pro Pro Gln Gly Ser Pro Thr Ala Ser Gln Ala 
    770                 775                 780                 


Pro Asn Gln Pro Gln Ala Pro Thr Ala Pro Val Pro His Thr His Ile 
785                 790                 795                 800 


Gln Gln Ala Pro Ala Leu His Pro Gln Arg Pro Pro Ser Pro His Pro 
                805                 810                 815     


Pro Pro His Pro Ser Pro His Pro Pro Leu Gln Pro Leu Thr Gly Ser 
            820                 825                 830         


Ala Gly Gln Pro Ser Ala Pro Ser His Ala Gln Pro Pro Leu His Gly 
        835                 840                 845             


Gln Gly Pro Pro Gly Pro His Ser Leu Gln Ala Gly Pro Leu Leu Gln 
    850                 855                 860                 


His Pro Gly Pro Pro Gln Pro Phe Gly Leu Pro Pro Gln Ala Ser Gln 
865                 870                 875                 880 


Gly Gln Ala Pro Leu Gly Thr Ser Pro Ala Ala Ala Tyr Pro His Thr 
                885                 890                 895     


Ser Leu Gln Leu Pro Ala Ser Gln Ser Ala Leu Gln Ser Gln Gln Pro 
            900                 905                 910         


Pro Arg Glu Gln Pro Leu Pro Pro Ala Pro Leu Ala Met Pro His Ile 
        915                 920                 925             


Lys Pro Pro Pro Thr Thr Pro Ile Pro Gln Leu Pro Ala Pro Gln Ala 
    930                 935                 940                 


His Lys His Pro Pro His Leu Ser Gly Pro Ser Pro Phe Ser Met Asn 
945                 950                 955                 960 


Ala Asn Leu Pro Pro Pro Pro Ala Leu Lys Pro Leu Ser Ser Leu Ser 
                965                 970                 975     


Thr His His Pro Pro Ser Ala His Pro Pro Pro Leu Gln Leu Met Pro 
            980                 985                 990         


Gln Ser Gln Pro Leu Pro Ser Ser  Pro Ala Gln Pro Pro  Gly Leu Thr 
        995                 1000                 1005             


Gln Ser  Gln Asn Leu Pro Pro  Pro Pro Ala Ser His  Pro Pro Thr 
    1010                 1015                 1020             


Gly Leu  His Gln Val Ala Pro  Gln Pro Pro Phe Ala  Gln His Pro 
    1025                 1030                 1035             


Phe Val  Pro Gly Gly Pro Pro  Pro Ile Thr Pro Pro  Thr Cys Pro 
    1040                 1045                 1050             


Ser Thr  Ser Thr Pro Pro Ala  Gly Pro Gly Thr Ser  Ala Gln Pro 
    1055                 1060                 1065             


Pro Cys  Ser Gly Ala Ala Ala  Ser Gly Gly Ser Ile  Ala Gly Gly 
    1070                 1075                 1080             


Ser Ser  Cys Pro Leu Pro Thr  Val Gln Ile Lys Glu  Glu Ala Leu 
    1085                 1090                 1095             


Asp Asp  Ala Glu Glu Pro Glu  Ser Pro Pro Pro Pro  Pro Arg Ser 
    1100                 1105                 1110             


Pro Ser  Pro Glu Pro Thr Val  Val Asp Thr Pro Ser  His Ala Ser 
    1115                 1120                 1125             


Gln Ser  Ala Arg Phe Tyr Lys  His Leu Asp Arg Gly  Tyr Asn Ser 
    1130                 1135                 1140             


Cys Ala  Arg Thr Asp Leu Tyr  Phe Met Pro Leu Ala  Gly Ser Lys 
    1145                 1150                 1155             


Leu Ala  Lys Lys Arg Glu Glu  Ala Ile Glu Lys Ala  Lys Arg Glu 
    1160                 1165                 1170             


Ala Glu  Gln Lys Ala Arg Glu  Glu Arg Glu Arg Glu  Lys Glu Lys 
    1175                 1180                 1185             


Glu Lys  Glu Arg Glu Arg Glu  Arg Glu Arg Glu Arg  Glu Ala Glu 
    1190                 1195                 1200             


Arg Ala  Ala Lys Ala Ser Ser  Ser Ala His Glu Gly  Arg Leu Ser 
    1205                 1210                 1215             


Asp Pro  Gln Leu Ser Gly Pro  Gly His Met Arg Pro  Ser Phe Glu 
    1220                 1225                 1230             


Pro Pro  Pro Thr Thr Ile Ala  Ala Val Pro Pro Tyr  Ile Gly Pro 
    1235                 1240                 1245             


Asp Thr  Pro Ala Leu Arg Thr  Leu Ser Glu Tyr Ala  Arg Pro His 
    1250                 1255                 1260             


Val Met  Ser Pro Thr Asn Arg  Asn His Pro Phe Tyr  Met Pro Leu 
    1265                 1270                 1275             


Asn Pro  Thr Asp Pro Leu Leu  Ala Tyr His Met Pro  Gly Leu Tyr 
    1280                 1285                 1290             


Asn Val  Asp Pro Thr Ile Arg  Glu Arg Glu Leu Arg  Glu Arg Glu 
    1295                 1300                 1305             


Ile Arg  Glu Arg Glu Ile Arg  Glu Arg Glu Leu Arg  Glu Arg Met 
    1310                 1315                 1320             


Lys Pro  Gly Phe Glu Val Lys  Pro Pro Glu Leu Asp  Pro Leu His 
    1325                 1330                 1335             


Pro Ala  Ala Asn Pro Met Glu  His Phe Ala Arg His  Ser Ala Leu 
    1340                 1345                 1350             


Thr Ile  Pro Pro Thr Ala Gly  Pro His Pro Phe Ala  Ser Phe His 
    1355                 1360                 1365             


Pro Gly  Leu Asn Pro Leu Glu  Arg Glu Arg Leu Ala  Leu Ala Gly 
    1370                 1375                 1380             


Pro Gln  Leu Arg Pro Glu Met  Ser Tyr Pro Asp Arg  Leu Ala Ala 
    1385                 1390                 1395             


Glu Arg  Ile His Ala Glu Arg  Met Ala Ser Leu Thr  Ser Asp Pro 
    1400                 1405                 1410             


Leu Ala  Arg Leu Gln Met Phe  Asn Val Thr Pro His  His His Gln 
    1415                 1420                 1425             


His Ser  His Ile His Ser His  Leu His Leu His Gln  Gln Asp Pro 
    1430                 1435                 1440             


Leu His  Gln Gly Ser Ala Gly  Pro Val His Pro Leu  Val Asp Pro 
    1445                 1450                 1455             


Leu Thr  Ala Gly Pro His Leu  Ala Arg Phe Pro Tyr  Pro Pro Gly 
    1460                 1465                 1470             


Thr Leu  Pro Asn Pro Leu Leu  Gly Gln Pro Pro His  Glu His Glu 
    1475                 1480                 1485             


Met Leu  Arg His Pro Val Phe  Gly Thr Pro Tyr Pro  Arg Asp Leu 
    1490                 1495                 1500             


Pro Gly  Ala Ile Pro Pro Pro  Met Ser Ala Ala His  Gln Leu Gln 
    1505                 1510                 1515             


Ala Met  His Ala Gln Ser Ala  Glu Leu Gln Arg Leu  Ala Met Glu 
    1520                 1525                 1530             


Gln Gln  Trp Leu His Gly His  Pro His Met His Gly  Gly His Leu 
    1535                 1540                 1545             


Pro Ser  Gln Glu Asp Tyr Tyr  Ser Arg Leu Lys Lys  Glu Gly Asp 
    1550                 1555                 1560             


Lys Gln  Leu 
    1565     


<210>  896
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  896

Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val 
1               5                   10                  15      


Leu Ala Val Ser Asp Gly Glu Leu Ser Ser Thr Thr Gly Pro Gln Gly 
            20                  25                  30          


Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser 
        35                  40                  45              


Gly Pro Ser Ser Pro Phe Pro Thr Glu Glu Gln Pro Val Ala Ser Trp 
    50                  55                  60                  


Ala Leu Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr 
65                  70                  75                  80  


Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe 
                85                  90                  95      


Trp Lys Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln 
            100                 105                 110         


Gln Leu Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser 
        115                 120                 125             


Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu 
    130                 135                 140                 


Glu Val Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu 
145                 150                 155                 160 


Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys 
                165                 170                 175     


Ser Pro Leu Tyr Arg Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro 
            180                 185                 190         


Leu Arg Glu Pro Gly Ser Ser Arg Leu Gly Ser Pro Asp Ala Thr Arg 
        195                 200                 205             


Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu 
    210                 215                 220                 


Glu Leu Gly Gln Leu Pro Pro Val Glu Gly Pro Gly Gly Arg Pro Leu 
225                 230                 235                 240 


Arg Lys Ser Phe Arg Arg Glu Leu Gly Gly Thr Ala Asn Ala Ala Leu 
                245                 250                 255     


Arg Arg Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu 
            260                 265                 270         


Gly Phe Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser 
        275                 280                 285             


Leu Gly Ser Thr Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys 
    290                 295                 300                 


Cys Val Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro 
305                 310                 315                 320 


Gly Leu Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly 
                325                 330                 335     


Leu Ser Leu Pro Asp Ile Lys Val Tyr Leu Val Gly Asn Glu Gln Ala 
            340                 345                 350         


Leu Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val Arg 
        355                 360                 365             


Leu Glu Asn Arg Ile Thr Phe Glu Leu Glu Leu Thr Ala Leu Glu Arg 
    370                 375                 380                 


Val Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala Leu 
385                 390                 395                 400 


Gln Pro Ile Leu Glu Lys His Gly Leu Ser Pro Leu Glu Val Val Leu 
                405                 410                 415     


His Arg Pro Gly Glu Lys Gln Pro Leu Asp Leu Gly Lys Leu Val Ser 
            420                 425                 430         


Ser Val Ala Ala Gln Arg Leu Val Leu Asp Thr Leu Pro Gly Val Lys 
        435                 440                 445             


Ile Ser Lys Ala Arg Asp Lys Ser Pro Cys Arg Ser Gln Gly Cys Pro 
    450                 455                 460                 


Pro Arg Thr Gln Asp Lys Ala Thr His Pro Pro Pro Ala Ser Pro Ser 
465                 470                 475                 480 


Ser Leu Val Lys Val Pro Ser Ser Ala Thr Gly Lys Arg Gln Thr Cys 
                485                 490                 495     


Asp Ile Glu Gly Leu Val Glu Leu Leu Asn Arg Val Gln Ser Ser Gly 
            500                 505                 510         


Ala His Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu Pro 
        515                 520                 525             


Glu Phe Leu Gln Leu Pro Ala Gln Gly Pro Ser Ser Glu Glu Thr Pro 
    530                 535                 540                 


Pro Gln Thr Lys Ser Ala Ala Gln Pro Ile Gly Gly Ser Leu Asn Ser 
545                 550                 555                 560 


Thr Thr Asp Ser Ala Leu 
                565     


<210>  897
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  897

Met Pro Thr Pro His Glu Ala Glu Lys Gln Ile Thr Gly Pro Glu Glu 
1               5                   10                  15      


Ala Asp Arg Pro Pro Ser Met Ser Ser His Asp Thr Ala Ser Pro Ala 
            20                  25                  30          


Ala Pro Ser Arg Asn Pro Cys Cys Leu Cys Trp Cys Cys Cys Cys Ser 
        35                  40                  45              


Cys Ser Trp Asn Gln Glu Arg Arg Arg Ala Trp Gln Ala Ser Arg Glu 
    50                  55                  60                  


Ser Lys Leu Gln Pro Leu Pro Ser Cys Glu Val Cys Ala Thr Pro Ser 
65                  70                  75                  80  


Pro Glu Glu Val Gln Ser Trp Ala Gln Ser Phe Asp Lys Leu Met His 
                85                  90                  95      


Ser Pro Ala Gly Arg Ser Val Phe Arg Ala Phe Leu Arg Thr Glu Tyr 
            100                 105                 110         


Ser Glu Glu Asn Met Leu Phe Trp Leu Ala Cys Glu Glu Leu Lys Ala 
        115                 120                 125             


Glu Ala Asn Gln His Val Val Asp Glu Lys Ala Arg Leu Ile Tyr Glu 
    130                 135                 140                 


Asp Tyr Val Ser Ile Leu Ser Pro Lys Glu Val Ser Leu Asp Ser Arg 
145                 150                 155                 160 


Val Arg Glu Gly Ile Asn Lys Lys Met Gln Glu Pro Ser Ala His Thr 
                165                 170                 175     


Phe Asp Asp Ala Gln Leu Gln Ile Tyr Thr Leu Met His Arg Asp Ser 
            180                 185                 190         


Tyr Pro Arg Phe Leu Ser Ser Pro Thr Tyr Arg Ala Leu Leu Leu Gln 
        195                 200                 205             


Gly Pro Ser Gln Ser Ser Ser Glu Ala 
    210                 215         


<210>  898
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  898

Met Gln Ser Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Cys Tyr Thr Thr Asn Ala Phe Pro Lys Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Gln Ser Ala Val Asp Gly 
        35                  40                  45              


Arg Thr Val Asn Leu Asn Leu Trp Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Thr Leu Ser Tyr Pro Gln Thr Asn Val Phe Val Ile 
65                  70                  75                  80  


Cys Phe Ser Ile Ala Ser Pro Pro Ser Tyr Glu Asn Val Arg His Lys 
                85                  90                  95      


Trp His Pro Glu Val Cys His His Cys Pro Asp Val Pro Ile Leu Leu 
            100                 105                 110         


Val Gly Thr Lys Lys Asp Leu Arg Ala Gln Pro Asp Thr Leu Arg Arg 
        115                 120                 125             


Leu Lys Glu Gln Gly Gln Ala Pro Ile Thr Pro Gln Gln Gly Gln Ala 
    130                 135                 140                 


Leu Ala Lys Gln Ile His Ala Val Arg Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Gln Gln Asp Gly Val Lys Glu Val Phe Ala Glu Ala Val Arg Ala Val 
                165                 170                 175     


Leu Asn Pro Thr Pro Ile Lys Arg Gly Arg Ser Cys Ile Leu Leu 
            180                 185                 190     


<210>  899
<211>  985
<212>  PRT
<213>  Homo sapiens

<400>  899

Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Val Leu Pro Ala Leu Ala 
    290                 295                 300                 


Pro Ala Pro Ala Cys Pro Leu Pro Thr Ser Pro Pro Val Pro Ala Pro 
305                 310                 315                 320 


His Val Thr Pro His Ala Pro Gly Pro Pro Asp His Pro Asn Gln Pro 
                325                 330                 335     


Pro Met Met Thr Cys Glu Arg Leu Pro Cys Pro Thr Ala Gly Leu Gly 
            340                 345                 350         


Pro Leu Arg Glu Glu Ala Met Lys Pro Gly Ala Ala Ser Ser Pro Leu 
        355                 360                 365             


Gln Gln Val Pro Ala Pro Pro Leu Pro Ala Lys Lys Asn Leu Pro Thr 
    370                 375                 380                 


Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser Leu Glu Asp Gln 
385                 390                 395                 400 


Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser Leu Pro Pro Gln 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu Ser Thr Glu Gln 
            420                 425                 430         


Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His Ser Met Pro Glu 
        435                 440                 445             


Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro Pro Arg Lys Lys 
    450                 455                 460                 


Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala Pro Leu Glu Asn 
465                 470                 475                 480 


Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr Pro Thr Pro Gly 
                485                 490                 495     


Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala Gly Thr Gln His 
            500                 505                 510         


Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser Pro Glu Phe Lys 
        515                 520                 525             


Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala 
    530                 535                 540                 


Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser Met Ile Leu Gly 
                565                 570                 575     


Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His 
            580                 585                 590         


Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu 
        595                 600                 605             


Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val Gln Asp Tyr Lys 
    610                 615                 620                 


Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser Ser Thr Glu Met 
625                 630                 635                 640 


Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys Ser Tyr Leu Leu 
                645                 650                 655     


Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu 
            660                 665                 670         


Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr Lys Cys Val Leu 
        675                 680                 685             


Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His Gln Ile His Ser 
    690                 695                 700                 


Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln Leu Val Ile Leu 
705                 710                 715                 720 


Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val 
                725                 730                 735     


Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser Met His Lys Ala 
            740                 745                 750         


Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys Thr Cys Lys Leu 
        755                 760                 765             


Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala 
    770                 775                 780                 


Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu 
785                 790                 795                 800 


Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro 
                805                 810                 815     


Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly 
            820                 825                 830         


Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr Val Thr Arg Gln 
        835                 840                 845             


Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp Glu Arg Arg Arg 
    850                 855                 860                 


Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val Gln Asp Phe Ile 
865                 870                 875                 880 


Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg Thr Leu Ala Ser 
                885                 890                 895     


Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln Cys Ala Glu Lys 
            900                 905                 910         


Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe Val Leu Val Asp 
        915                 920                 925             


Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro His Cys Ile Lys 
    930                 935                 940                 


Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe His Phe Val Tyr 
945                 950                 955                 960 


Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly Ser Pro Pro Cys 
                965                 970                 975     


Leu Val Val Arg Glu Pro Asn Phe Leu 
            980                 985 


<210>  900
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  900

Met Arg Pro Ala Ala Leu Arg Gly Ala Leu Leu Gly Cys Leu Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Leu Gly Gly Ala Asp Lys Arg Leu Arg Asp Asn His 
            20                  25                  30          


Glu Trp Lys Lys Leu Ile Met Val Gln His Trp Pro Glu Thr Val Cys 
        35                  40                  45              


Glu Lys Ile Gln Asn Asp Cys Arg Asp Pro Pro Asp Tyr Trp Thr Ile 
    50                  55                  60                  


His Gly Leu Trp Pro Asp Lys Ser Glu Gly Cys Asn Arg Ser Trp Pro 
65                  70                  75                  80  


Phe Asn Leu Glu Glu Ile Lys Asp Leu Leu Pro Glu Met Arg Ala Tyr 
                85                  90                  95      


Trp Pro Asp Val Ile His Ser Phe Pro Asn Arg Ser Arg Phe Trp Lys 
            100                 105                 110         


His Glu Trp Glu Lys His Gly Thr Cys Ala Ala Gln Val Asp Ala Leu 
        115                 120                 125             


Asn Ser Gln Lys Lys Tyr Phe Gly Arg Ser Leu Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Leu Asp Leu Asn Ser Val Leu Leu Lys Leu Gly Ile Lys Pro Ser Ile 
145                 150                 155                 160 


Asn Tyr Tyr Gln Val Ala Asp Phe Lys Asp Ala Leu Ala Arg Val Tyr 
                165                 170                 175     


Gly Val Ile Pro Lys Ile Gln Cys Leu Pro Pro Ser Gln Asp Glu Glu 
            180                 185                 190         


Val Gln Thr Ile Gly Gln Ile Glu Leu Cys Leu Thr Lys Gln Asp Gln 
        195                 200                 205             


Gln Leu Gln Asn Cys Thr Glu Pro Gly Glu Gln Pro Ser Pro Lys Gln 
    210                 215                 220                 


Glu Val Trp Leu Ala Asn Gly Ala Ala Glu Ser Arg Gly Leu Arg Val 
225                 230                 235                 240 


Cys Glu Asp Gly Pro Val Phe Tyr Pro Pro Pro Lys Lys Thr Lys His 
                245                 250                 255     


<210>  901
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  901

Met Ser Cys Ala Gly Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
1               5                   10                  15      


Leu Leu Thr Cys Ser Leu Trp Pro Ala Arg Ala Asp Asn Ala Ser Gln 
            20                  25                  30          


Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
        35                  40                  45              


Gly Ala Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
    50                  55                  60                  


Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Leu 
65                  70                  75                  80  


His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                85                  90                  95      


Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
            100                 105                 110         


Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
        115                 120                 125             


Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
    130                 135                 140                 


Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
145                 150                 155                 160 


Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                165                 170                 175     


Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
            180                 185                 190         


Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
        195                 200                 205             


Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
    210                 215                 220                 


Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
225                 230                 235                 240 


Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                245                 250                 255     


Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
            260                 265                 270         


Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His Lys 
        275                 280                 285             


Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
    290                 295                 300                 


Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
305                 310                 315                 320 


Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                325                 330                 335     


Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser Leu 
            340                 345                 350         


Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
        355                 360                 365             


Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
    370                 375                 380                 


Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
385                 390                 395                 400 


Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                405                 410                 415     


Glu Trp Phe 
            


<210>  902
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  902

Met Gly Gln Gln Ile Ser Asp Gln Thr Gln Leu Val Ile Asn Lys Leu 
1               5                   10                  15      


Pro Glu Lys Val Ala Lys His Val Thr Leu Val Arg Glu Ser Gly Ser 
            20                  25                  30          


Leu Thr Tyr Glu Glu Phe Leu Gly Arg Val Ala Glu Leu Asn Asp Val 
        35                  40                  45              


Thr Ala Lys Val Ala Ser Gly Gln Glu Lys His Leu Leu Phe Glu Val 
    50                  55                  60                  


Gln Pro Gly Ser Asp Ser Ser Ala Phe Trp Lys Val Val Val Arg Val 
65                  70                  75                  80  


Val Cys Thr Lys Ile Asn Lys Ser Ser Gly Ile Val Glu Ala Ser Arg 
                85                  90                  95      


Ile Met Asn Leu Tyr Gln Phe Ile Gln Leu Tyr Lys Asp Ile Thr Ser 
            100                 105                 110         


Gln Ala Ala Gly Val Leu Ala Gln Ser Ser Thr Ser Glu Glu Pro Asp 
        115                 120                 125             


Glu Asn Ser Ser Ser Val Thr Ser Cys Gln Ala Ser Leu Trp Met Gly 
    130                 135                 140                 


Arg Val Lys Gln Leu Thr Asp Glu Glu Glu Cys Cys Ile Cys Met Asp 
145                 150                 155                 160 


Gly Arg Ala Asp Leu Ile Leu Pro Cys Ala His Ser Phe Cys Gln Lys 
                165                 170                 175     


Cys Ile Asp Lys Trp Ser Asp Arg His Arg Asn Cys Pro Ile Cys Arg 
            180                 185                 190         


Leu Gln Met Thr Gly Ala Asn Glu Ser Trp Val Val Ser Asp Ala Pro 
        195                 200                 205             


Thr Glu Asp Asp Met Ala Asn Tyr Ile Leu Asn Met Ala Asp Glu Ala 
    210                 215                 220                 


Gly Gln Pro His Arg Pro 
225                 230 


<210>  903
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  903

Met Ala Gly Cys Gly Glu Ile Asp His Ser Ile Asn Met Leu Pro Thr 
1               5                   10                  15      


Asn Arg Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser Leu Thr 
            20                  25                  30          


Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val Ser 
        35                  40                  45              


Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala Ser 
    50                  55                  60                  


Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro Glu Asp 
65                  70                  75                  80  


Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys Ala Ala 
                85                  90                  95      


Ser Arg Gly Asn Gly Glu Tyr Ala Trp Tyr Tyr Glu Gly Arg Asn Gly 
            100                 105                 110         


Trp Trp Gln Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala Phe 
        115                 120                 125             


Ser Lys Gly Lys Lys Asn Thr Glu Met Leu Ile Ala Gly Phe Leu Tyr 
    130                 135                 140                 


Val Ala Asp Leu Glu Asn Met Val Gln Tyr Arg Arg Asn Glu His Gly 
145                 150                 155                 160 


Arg Arg Arg Lys Ile Lys Arg Asp Ile Ile Asp Ile Pro Lys Lys Gly 
                165                 170                 175     


Val Ala Gly Leu Arg Leu Asp Cys Asp Ala Asn Thr Val Asn Leu Ala 
            180                 185                 190         


Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Val Ser Ala Gln Ser Gly 
        195                 200                 205             


Ala Ser Val Gln Pro Leu Val Ser Ser Val Arg Pro Leu Thr Ser Val 
    210                 215                 220                 


Asp Gly Gln Leu Thr Ser Pro Ala Thr Pro Ser Pro Asp Ala Ser Thr 
225                 230                 235                 240 


Ser Leu Glu Asp Ser Phe Ala His Leu Gln Leu Ser Gly Asp Asn Thr 
                245                 250                 255     


Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His Glu Ser Pro 
            260                 265                 270         


Ser Ser Gly Arg Val Pro Ala Pro Asp Thr Ser Ile Glu Glu Thr Glu 
        275                 280                 285             


Ser Asp Ala Ser Ser Asp Ser Glu Asp Val Ser Ala Val Val Ala Gln 
    290                 295                 300                 


His Ser Leu Thr Gln Gln Arg Leu Leu Val Ser Asn Ala Asn Gln Thr 
305                 310                 315                 320 


Val Pro Asp Arg Ser Asp Arg Ser Gly Thr Asp Arg Ser Val Ala Gly 
                325                 330                 335     


Gly Gly Thr Val Ser Val Ser Val Arg Ser Arg Arg Pro Asp Gly Gln 
            340                 345                 350         


Cys Thr Val Thr Glu Val 
        355             


<210>  904
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  904

Met Gly Ser Glu Lys Asp Ser Glu Ser Pro Arg Ser Thr Ser Leu His 
1               5                   10                  15      


Ala Ala Ala Pro Asp Pro Lys Cys Arg Ser Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


Leu Thr Leu His Ser Val Phe Ser Ala Ser Ala Arg Gly Arg Arg Ala 
        35                  40                  45              


Arg Ala Lys Pro Gln Ala Glu Pro Pro Pro Pro Ala Ala Gln Pro Pro 
    50                  55                  60                  


Pro Ala Pro Ala Pro Ala Ala Ala Gln Gly Pro Pro Pro Glu Ala Leu 
65                  70                  75                  80  


Pro Ala Glu Pro Ala Ala Glu Ala Glu Ala Glu Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Glu Pro Gly Phe Asp Asp Glu Glu Ala Ala Glu Gly Gly Gly Pro 
            100                 105                 110         


Gly Ala Glu Glu Val Glu Cys Pro Leu Cys Leu Val Arg Leu Pro Pro 
        115                 120                 125             


Glu Arg Ala Pro Arg Leu Leu Ser Cys Pro His Arg Ser Cys Arg Asp 
    130                 135                 140                 


Cys Leu Arg His Tyr Leu Arg Leu Glu Ile Ser Glu Ser Arg Val Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Cys Ser Glu Arg Leu Asn Pro His Asp Ile Arg 
                165                 170                 175     


Leu Leu Leu Ala Asp Pro Pro Leu Met His Lys Tyr Glu Glu Phe Met 
            180                 185                 190         


Leu Arg Arg Tyr Leu Ala Ser Asp Pro Asp Cys Arg Trp Cys Pro Ala 
        195                 200                 205             


Pro Asp Cys Gly Tyr Ala Val Ile Ala Tyr Gly Cys Ala Ser Cys Pro 
    210                 215                 220                 


Lys Leu Thr Cys Glu Arg Glu Gly Cys Gln Thr Glu Phe Cys Tyr His 
225                 230                 235                 240 


Cys Lys Gln Ile Trp His Pro Asn Gln Thr Cys Asp Met Ala Arg Gln 
                245                 250                 255     


Gln Arg Ala Gln Thr Leu Arg Val Arg Thr Lys His Thr Ser Gly Leu 
            260                 265                 270         


Ser Tyr Gly Gln Glu Ser Gly Pro Ala Asp Asp Ile Lys Pro Cys Pro 
        275                 280                 285             


Arg Cys Ser Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His 
    290                 295                 300                 


Met Thr Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys 
305                 310                 315                 320 


Glu Ile Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp 
                325                 330                 335     


Gly Lys Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly 
            340                 345                 350         


Thr Leu Ile Gly Ala Pro Val Gly Ile Ser Leu Ile Ala Gly Ile Ala 
        355                 360                 365             


Ile Pro Ala Met Val Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile 
    370                 375                 380                 


His Ser Arg Tyr Glu Gly Arg Lys Thr Ser Lys His Lys Arg Asn Leu 
385                 390                 395                 400 


Ala Ile Thr Gly Gly Val Thr Leu Ser Val Ile Ala Ser Pro Val Ile 
                405                 410                 415     


Ala Ala Val Ser Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val 
            420                 425                 430         


Tyr Gly Val Val Pro Ile Ser Leu Cys Arg Gly Gly Gly Cys Gly Val 
        435                 440                 445             


Ser Thr Ala Asn Gly Lys Gly Val Lys Ile Glu Phe Asp Glu Asp Asp 
    450                 455                 460                 


Gly Pro Ile Thr Val Ala Asp Ala Trp Arg Ala Leu Lys Asn Pro Ser 
465                 470                 475                 480 


Ile Gly Glu Ser Ser Ile Glu Gly Leu Thr Ser Val Leu Ser Thr Ser 
                485                 490                 495     


Gly Ser Pro Thr Asp Gly Leu Ser Val Met Gln Gly Pro Tyr Ser Glu 
            500                 505                 510         


Thr Ala Ser Phe Ala Ala Leu Ser Gly Gly Thr Leu Ser Gly Gly Ile 
        515                 520                 525             


Leu Ser Ser Gly Lys Gly Lys Tyr Ser Arg Leu Glu Val Gln Ala Asp 
    530                 535                 540                 


Val Gln Lys Glu Ile Phe Pro Lys Asp Thr Ala Ser Leu Gly Ala Ile 
545                 550                 555                 560 


Ser Asp Asn Ala Ser Thr Arg Ala Met Ala Gly Ser Ile Ile Ser Ser 
                565                 570                 575     


Tyr Asn Pro Gln Asp Arg Glu Cys Asn Asn Met Glu Ile Gln Val Asp 
            580                 585                 590         


Ile Glu Ala Lys Pro Ser His Tyr Gln Leu Val Ser Gly Ser Ser Thr 
        595                 600                 605             


Glu Asp Ser Leu His Val His Ala Gln Met Ala Glu Asn Glu Glu Glu 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Pro Cys Arg His Gln 
625                 630                 635                 640 


Ser Cys Glu Gln Lys Asp Cys Leu Ala Ser Lys Pro Trp Asp Ile Ser 
                645                 650                 655     


Leu Ala Gln Pro Glu Ser Ile Arg Ser Asp Leu Glu Ser Ser Asp Ala 
            660                 665                 670         


Gln Ser Asp Asp Val Pro Asp Ile Thr Ser Asp Glu Cys Gly Ser Pro 
        675                 680                 685             


Arg Ser His Thr Ala Ala Cys Pro Ser Thr Pro Arg Ala Gln Gly Ala 
    690                 695                 700                 


Pro Ser Pro Ser Ala His Met Asn Leu Ser Ala Leu Ala Glu Gly Gln 
705                 710                 715                 720 


Thr Val Leu Lys Pro Glu Gly Gly Glu Ala Arg Val 
                725                 730         


<210>  905
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  905

Met Ser Ser Lys Val Ser Arg Asp Thr Leu Tyr Glu Ala Val Arg Glu 
1               5                   10                  15      


Val Leu His Gly Asn Gln Arg Lys Arg Arg Lys Phe Leu Glu Thr Val 
            20                  25                  30          


Glu Leu Gln Ile Ser Leu Lys Asn Tyr Asp Pro Gln Lys Asp Lys Arg 
        35                  40                  45              


Phe Ser Gly Thr Val Arg Leu Lys Ser Thr Pro Arg Pro Lys Phe Ser 
    50                  55                  60                  


Val Cys Val Leu Gly Asp Gln Gln His Cys Asp Glu Ala Lys Ala Val 
65                  70                  75                  80  


Asp Ile Pro His Met Asp Ile Glu Ala Leu Lys Lys Leu Asn Lys Asn 
                85                  90                  95      


Lys Lys Leu Val Lys Lys Leu Ala Lys Lys Tyr Asp Ala Phe Leu Ala 
            100                 105                 110         


Ser Glu Ser Leu Ile Lys Gln Ile Pro Arg Ile Leu Gly Pro Gly Leu 
        115                 120                 125             


Asn Lys Ala Gly Lys Phe Pro Ser Leu Leu Thr His Asn Glu Asn Met 
    130                 135                 140                 


Val Ala Lys Val Asp Glu Val Lys Ser Thr Ile Lys Phe Gln Met Lys 
145                 150                 155                 160 


Lys Val Leu Cys Leu Ala Val Ala Val Gly His Val Lys Met Thr Asp 
                165                 170                 175     


Asp Glu Leu Val Tyr Asn Ile His Leu Ala Val Asn Phe Leu Val Ser 
            180                 185                 190         


Leu Leu Lys Lys Asn Trp Gln Asn Val Arg Ala Leu Tyr Ile Lys Ser 
        195                 200                 205             


Thr Met Gly Lys Pro Gln Arg Leu Tyr 
    210                 215         


<210>  906
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  906

Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys 
1               5                   10                  15      


Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly 
            20                  25                  30          


Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys 
        35                  40                  45              


Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu 
    50                  55                  60                  


Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys 
65                  70                  75                  80  


Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu 
                85                  90                  95      


Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu 
            100                 105                 110         


Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp 
        115                 120                 125             


<210>  907
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  907

Met Pro Leu Ala Gln Leu Lys Glu Pro Trp Pro Leu Met Glu Leu Val 
1               5                   10                  15      


Pro Leu Asp Pro Glu Asn Gly Gln Thr Ser Gly Glu Glu Ala Gly Leu 
            20                  25                  30          


Gln Pro Ser Lys Asp Glu Gly Val Leu Lys Glu Ile Ser Ile Thr His 
        35                  40                  45              


His Val Lys Ala Gly Ser Glu Lys Ala Asp Pro Ser His Phe Glu Leu 
    50                  55                  60                  


Leu Lys Val Leu Gly Gln Gly Ser Phe Gly Lys Val Phe Leu Val Arg 
65                  70                  75                  80  


Lys Val Thr Arg Pro Asp Ser Gly His Leu Tyr Ala Met Lys Val Leu 
                85                  90                  95      


Lys Lys Ala Thr Leu Lys Val Arg Asp Arg Val Arg Thr Lys Met Glu 
            100                 105                 110         


Arg Asp Ile Leu Ala Asp Val Asn His Pro Phe Val Val Lys Leu His 
        115                 120                 125             


Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr Leu Ile Leu Asp Phe Leu 
    130                 135                 140                 


Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser Lys Glu Val Met Phe Thr 
145                 150                 155                 160 


Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu Leu Ala Leu Gly Leu Asp 
                165                 170                 175     


His Leu His Ser Leu Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
            180                 185                 190         


Ile Leu Leu Asp Glu Glu Gly His Ile Lys Leu Thr Asp Phe Gly Leu 
        195                 200                 205             


Ser Lys Glu Ala Ile Asp His Glu Lys Lys Ala Tyr Ser Phe Cys Gly 
    210                 215                 220                 


Thr Val Glu Tyr Met Ala Pro Glu Val Val Asn Arg Gln Gly His Ser 
225                 230                 235                 240 


His Ser Ala Asp Trp Trp Ser Tyr Gly Val Leu Met Phe Glu Met Leu 
                245                 250                 255     


Thr Gly Ser Leu Pro Phe Gln Gly Lys Asp Arg Lys Glu Thr Met Thr 
            260                 265                 270         


Leu Ile Leu Lys Ala Lys Leu Gly Met Pro Gln Phe Leu Ser Thr Glu 
        275                 280                 285             


Ala Gln Ser Leu Leu Arg Ala Leu Phe Lys Arg Asn Pro Ala Asn Arg 
    290                 295                 300                 


Leu Gly Ser Gly Pro Asp Gly Ala Glu Glu Ile Lys Arg His Val Phe 
305                 310                 315                 320 


Tyr Ser Thr Ile Asp Trp Asn Lys Leu Tyr Arg Arg Glu Ile Lys Pro 
                325                 330                 335     


Pro Phe Lys Pro Ala Val Ala Gln Pro Asp Asp Thr Phe Tyr Phe Asp 
            340                 345                 350         


Thr Glu Phe Thr Ser Arg Thr Pro Lys Asp Ser Pro Gly Ile Pro Pro 
        355                 360                 365             


Ser Ala Gly Ala His Gln Leu Phe Arg Gly Phe Ser Phe Val Ala Thr 
    370                 375                 380                 


Gly Leu Met Glu Asp Asp Gly Lys Pro Arg Ala Pro Gln Ala Pro Leu 
385                 390                 395                 400 


His Ser Val Val Gln Gln Leu His Gly Lys Asn Leu Val Phe Ser Asp 
                405                 410                 415     


Gly Tyr Val Val Lys Glu Thr Ile Gly Val Gly Ser Tyr Ser Glu Cys 
            420                 425                 430         


Lys Arg Cys Val His Lys Ala Thr Asn Met Glu Tyr Ala Val Lys Val 
        435                 440                 445             


Ile Asp Lys Ser Lys Arg Asp Pro Ser Glu Glu Ile Glu Ile Leu Leu 
    450                 455                 460                 


Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys Asp Val Tyr Asp 
465                 470                 475                 480 


Asp Gly Lys His Val Tyr Leu Val Thr Glu Leu Met Arg Gly Gly Glu 
                485                 490                 495     


Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser Glu Arg Glu Ala 
            500                 505                 510         


Ser Phe Val Leu His Thr Ile Gly Lys Thr Val Glu Tyr Leu His Ser 
        515                 520                 525             


Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn Ile Leu Tyr Val 
    530                 535                 540                 


Asp Glu Ser Gly Asn Pro Glu Cys Leu Arg Ile Cys Asp Phe Gly Phe 
545                 550                 555                 560 


Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met Thr Pro Cys Tyr 
                565                 570                 575     


Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg Gln Gly Tyr Asp 
            580                 585                 590         


Glu Gly Cys Asp Ile Trp Ser Leu Gly Ile Leu Leu Tyr Thr Met Leu 
        595                 600                 605             


Ala Gly Tyr Thr Pro Phe Ala Asn Gly Pro Ser Asp Thr Pro Glu Glu 
    610                 615                 620                 


Ile Leu Thr Arg Ile Gly Ser Gly Lys Phe Thr Leu Ser Gly Gly Asn 
625                 630                 635                 640 


Trp Asn Thr Val Ser Glu Thr Ala Lys Asp Leu Val Ser Lys Met Leu 
                645                 650                 655     


His Val Asp Pro His Gln Arg Leu Thr Ala Lys Gln Val Leu Gln His 
            660                 665                 670         


Pro Trp Val Thr Gln Lys Asp Lys Leu Pro Gln Ser Gln Leu Ser His 
        675                 680                 685             


Gln Asp Leu Gln Leu Val Lys Gly Ala Met Ala Ala Thr Tyr Ser Ala 
    690                 695                 700                 


Leu Asn Ser Ser Lys Pro Thr Pro Gln Leu Lys Pro Ile Glu Ser Ser 
705                 710                 715                 720 


Ile Leu Ala Gln Arg Arg Val Arg Lys Leu Pro Ser Thr Thr Leu 
                725                 730                 735 


<210>  908
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  908

Met Pro Leu Ala Gln Leu Ala Asp Pro Trp Gln Lys Met Ala Val Glu 
1               5                   10                  15      


Ser Pro Ser Asp Ser Ala Glu Asn Gly Gln Gln Ile Met Asp Glu Pro 
            20                  25                  30          


Met Gly Glu Glu Glu Ile Asn Pro Gln Thr Glu Glu Val Ser Ile Lys 
        35                  40                  45              


Glu Ile Ala Ile Thr His His Val Lys Glu Gly His Glu Lys Ala Asp 
    50                  55                  60                  


Pro Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Phe Gly 
65                  70                  75                  80  


Lys Val Phe Leu Val Lys Lys Ile Ser Gly Ser Asp Ala Arg Gln Leu 
                85                  90                  95      


Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg 
            100                 105                 110         


Val Arg Thr Lys Met Glu Arg Asp Ile Leu Val Glu Val Asn His Pro 
        115                 120                 125             


Phe Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr 
    130                 135                 140                 


Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu 
                165                 170                 175     


Leu Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg 
            180                 185                 190         


Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys 
        195                 200                 205             


Leu Thr Asp Phe Gly Leu Ser Lys Glu Ser Ile Asp His Glu Lys Lys 
    210                 215                 220                 


Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro Glu Val Val 
225                 230                 235                 240 


Asn Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val 
                245                 250                 255     


Leu Met Phe Glu Met Leu Thr Gly Thr Leu Pro Phe Gln Gly Lys Asp 
            260                 265                 270         


Arg Lys Glu Thr Met Thr Met Ile Leu Lys Ala Lys Leu Gly Met Pro 
        275                 280                 285             


Gln Phe Leu Ser Pro Glu Ala Gln Ser Leu Leu Arg Met Leu Phe Lys 
    290                 295                 300                 


Arg Asn Pro Ala Asn Arg Leu Gly Ala Gly Pro Asp Gly Val Glu Glu 
305                 310                 315                 320 


Ile Lys Arg His Ser Phe Phe Ser Thr Ile Asp Trp Asn Lys Leu Tyr 
                325                 330                 335     


Arg Arg Glu Ile His Pro Pro Phe Lys Pro Ala Thr Gly Arg Pro Glu 
            340                 345                 350         


Asp Thr Phe Tyr Phe Asp Pro Glu Phe Thr Ala Lys Thr Pro Lys Asp 
        355                 360                 365             


Ser Pro Gly Ile Pro Pro Ser Ala Asn Ala His Gln Leu Phe Arg Gly 
    370                 375                 380                 


Phe Ser Phe Val Ala Ile Thr Ser Asp Asp Glu Ser Gln Ala Met Gln 
385                 390                 395                 400 


Thr Val Gly Val His Ser Ile Val Gln Gln Leu His Arg Asn Ser Ile 
                405                 410                 415     


Gln Phe Thr Asp Gly Tyr Glu Val Lys Glu Asp Ile Gly Val Gly Ser 
            420                 425                 430         


Tyr Ser Val Cys Lys Arg Cys Ile His Lys Ala Thr Asn Met Glu Phe 
        435                 440                 445             


Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Thr Glu Glu Ile 
    450                 455                 460                 


Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys 
465                 470                 475                 480 


Asp Val Tyr Asp Asp Gly Lys Tyr Val Tyr Val Val Thr Glu Leu Met 
                485                 490                 495     


Lys Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser 
            500                 505                 510         


Glu Arg Glu Ala Ser Ala Val Leu Phe Thr Ile Thr Lys Thr Val Glu 
        515                 520                 525             


Tyr Leu His Ala Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn 
    530                 535                 540                 


Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu Ser Ile Arg Ile Cys 
545                 550                 555                 560 


Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met 
                565                 570                 575     


Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg 
            580                 585                 590         


Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Val Leu Leu 
        595                 600                 605             


Tyr Thr Met Leu Thr Gly Tyr Thr Pro Phe Ala Asn Gly Pro Asp Asp 
    610                 615                 620                 


Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Phe Ser Leu 
625                 630                 635                 640 


Ser Gly Gly Tyr Trp Asn Ser Val Ser Asp Thr Ala Lys Asp Leu Val 
                645                 650                 655     


Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Ala Leu 
            660                 665                 670         


Val Leu Arg His Pro Trp Ile Val His Trp Asp Gln Leu Pro Gln Tyr 
        675                 680                 685             


Gln Leu Asn Arg Gln Asp Ala Pro His Leu Val Lys Gly Ala Met Ala 
    690                 695                 700                 


Ala Thr Tyr Ser Ala Leu Asn Arg Asn Gln Ser Pro Val Leu Glu Pro 
705                 710                 715                 720 


Val Gly Arg Ser Thr Leu Ala Gln Arg Arg Gly Ile Lys Lys Ile Thr 
                725                 730                 735     


Ser Thr Ala Leu 
            740 


<210>  909
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  909

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  910
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  910

Met Ala Glu Pro Ser Ala Ala Thr Gln Ser His Ser Ile Ser Ser Ser 
1               5                   10                  15      


Ser Phe Gly Ala Glu Pro Ser Ala Pro Gly Gly Gly Gly Ser Pro Gly 
            20                  25                  30          


Ala Cys Pro Ala Leu Gly Thr Lys Ser Cys Ser Ser Ser Cys Ala Val 
        35                  40                  45              


His Asp Leu Ile Phe Trp Arg Asp Val Lys Lys Thr Gly Phe Val Phe 
    50                  55                  60                  


Gly Thr Thr Leu Ile Met Leu Leu Ser Leu Ala Ala Phe Ser Val Ile 
65                  70                  75                  80  


Ser Val Val Ser Tyr Leu Ile Leu Ala Leu Leu Ser Val Thr Ile Ser 
                85                  90                  95      


Phe Arg Ile Tyr Lys Ser Val Ile Gln Ala Val Gln Lys Ser Glu Glu 
            100                 105                 110         


Gly His Pro Phe Lys Ala Tyr Leu Asp Val Asp Ile Thr Leu Ser Ser 
        115                 120                 125             


Glu Ala Phe His Asn Tyr Met Asn Ala Ala Met Val His Ile Asn Arg 
    130                 135                 140                 


Ala Leu Lys Leu Ile Ile Arg Leu Phe Leu Val Glu Asp Leu Val Asp 
145                 150                 155                 160 


Ser Leu Lys Leu Ala Val Phe Met Trp Leu Met Thr Tyr Val Gly Ala 
                165                 170                 175     


Val Phe Asn Gly Ile Thr Leu Leu Ile Leu Ala Glu Leu Leu Ile Phe 
            180                 185                 190         


Ser Val Pro Ile Val Tyr Glu Lys Tyr Lys Thr Gln Ile Asp His Tyr 
        195                 200                 205             


Val Gly Ile Ala Arg Asp Gln Thr Lys Ser Ile Val Glu Lys Ile Gln 
    210                 215                 220                 


Ala Lys Leu Pro Gly Ile Ala Lys Lys Lys Ala Glu 
225                 230                 235     


<210>  911
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  911

Met Val Val Asp Phe Trp Thr Trp Glu Gln Thr Phe Gln Glu Leu Ile 
1               5                   10                  15      


Gln Glu Ala Lys Pro Arg Ala Thr Trp Thr Leu Lys Leu Asp Gly Asn 
            20                  25                  30          


Leu Gln Leu Asp Cys Leu Ala Gln Gly Trp Lys Gln Tyr Gln Gln Arg 
        35                  40                  45              


Ala Phe Gly Trp Phe Arg Cys Ser Ser Cys Gln Arg Ser Trp Ala Ser 
    50                  55                  60                  


Ala Gln Val Gln Ile Leu Cys His Thr Tyr Trp Glu His Trp Thr Ser 
65                  70                  75                  80  


Gln Gly Gln Val Arg Met Arg Leu Phe Gly Gln Arg Cys Gln Lys Cys 
                85                  90                  95      


Ser Trp Ser Gln Tyr Glu Met Pro Glu Phe Ser Ser Asp Ser Thr Met 
            100                 105                 110         


Arg Ile Leu Ser Asn Leu Val Gln His Ile Leu Lys Lys Tyr Tyr Gly 
        115                 120                 125             


Asn Gly Thr Arg Lys Ser Pro Glu Met Pro Val Ile Leu Glu Val Ser 
    130                 135                 140                 


Leu Glu Gly Ser His Asp Thr Ala Asn Cys Glu Ala Cys Thr Leu Gly 
145                 150                 155                 160 


Ile Cys Gly Gln Gly Leu Lys Ser Cys Met Thr Lys Pro Ser Lys Ser 
                165                 170                 175     


Leu Leu Pro His Leu Lys Thr Gly Asn Ser Ser Pro Gly Ile Gly Ala 
            180                 185                 190         


Val Tyr Leu Ala Asn Gln Ala Lys Asn Gln Ser Ala Glu Ala Lys Glu 
        195                 200                 205             


Ala Lys Gly Ser Gly Tyr Glu Lys Leu Gly Pro Ser Arg Asp Pro Asp 
    210                 215                 220                 


Pro Leu Asn Ile Cys Val Phe Ile Leu Leu Leu Val Phe Ile Val Val 
225                 230                 235                 240 


Lys Cys Phe Thr Ser Glu 
                245     


<210>  912
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  912

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


<210>  913
<211>  317
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  913

Xaa Leu Pro Ala Pro Ala Ala Ala Leu Pro Gly Ala Pro Pro Pro Pro 
1               5                   10                  15      


Pro Gly Val Arg Gly Tyr Pro Ala Arg Ala Arg Gly Leu Gln Gly Ala 
            20                  25                  30          


Ser Gly Gly Ala Arg Phe Pro Ser Ser Leu Ser Leu Pro Val Pro Gly 
        35                  40                  45              


Lys Gly Gly Trp Val Val Ser Arg Ala Lys Phe Pro Ala Leu Asp Ser 
    50                  55                  60                  


Cys Glu Ile Thr Thr Ala His Pro Arg Leu Cys Phe Ala Val Ser Pro 
65                  70                  75                  80  


Pro Phe Ser Cys Ser Leu Pro Leu Pro Ser Leu Phe Pro His Ser Pro 
                85                  90                  95      


Leu Leu Gly Arg Pro Lys Arg Gln Ala Lys Pro Ala Ala Asp Glu Gly 
            100                 105                 110         


Phe Trp Asp Cys Ser Val Cys Thr Phe Arg Asn Ser Ala Glu Ala Phe 
        115                 120                 125             


Lys Cys Ser Ile Cys Asp Val Arg Lys Gly Thr Ser Thr Arg Lys Pro 
    130                 135                 140                 


Arg Ile Asn Ser Gln Leu Val Ala Gln Gln Val Ala Gln Gln Tyr Ala 
145                 150                 155                 160 


Thr Pro Pro Pro Pro Lys Lys Glu Lys Lys Glu Lys Val Glu Lys Gln 
                165                 170                 175     


Asp Lys Glu Lys Pro Glu Lys Asp Lys Glu Ile Ser Pro Ser Val Thr 
            180                 185                 190         


Lys Lys Asn Thr Asn Lys Lys Thr Lys Pro Lys Ser Asp Ile Leu Lys 
        195                 200                 205             


Asp Pro Pro Ser Glu Ala Asn Ser Ile Gln Ser Ala Asn Ala Thr Thr 
    210                 215                 220                 


Lys Thr Ser Glu Thr Asn His Thr Ser Arg Pro Arg Leu Lys Asn Val 
225                 230                 235                 240 


Asp Arg Ser Thr Ala Gln Gln Leu Ala Val Thr Val Gly Asn Val Thr 
                245                 250                 255     


Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Arg Ser Ser Ser Thr Ser 
            260                 265                 270         


Ser Ser Thr Val Thr Ser Ser Ala Gly Ser Glu Gln Gln Asn Gln Ser 
        275                 280                 285             


Ser Ser Gly Ser Glu Ser Thr Asp Lys Gly Ser Ser Arg Ser Ser Thr 
    290                 295                 300                 


Pro Lys Gly Asp Met Ser Ala Val Asn Asp Glu Ser Phe 
305                 310                 315         


<210>  914
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  914

Met Ala Glu Thr Leu Pro Gly Ser Gly Asp Ser Gly Pro Gly Thr Ala 
1               5                   10                  15      


Ser Leu Gly Pro Gly Val Ala Glu Thr Gly Thr Arg Arg Leu Ser Glu 
            20                  25                  30          


Leu Arg Val Ile Asp Leu Arg Ala Glu Leu Lys Lys Arg Asn Leu Asp 
        35                  40                  45              


Thr Gly Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys Lys Ala Val 
    50                  55                  60                  


Lys Glu Glu Gly Gln Asp Pro Asp Glu Ile Gly Ile Glu Leu Glu Ala 
65                  70                  75                  80  


Thr Ser Lys Lys Ser Ala Lys Arg Cys Val Lys Gly Leu Lys Met Glu 
                85                  90                  95      


Glu Glu Gly Thr Glu Asp Asn Gly Leu Glu Asp Asp Ser Arg Asp Gly 
            100                 105                 110         


Gln Glu Asp Met Glu Ala Ser Leu Glu Asn Leu Gln Asn Met Gly Met 
        115                 120                 125             


Met Asp Met Ser Val Leu Asp Glu Thr Glu Val Ala Asn Ser Ser Ala 
    130                 135                 140                 


Pro Asp Phe Gly Glu Asp Gly Thr Asp Gly Leu Leu Asp Ser Phe Cys 
145                 150                 155                 160 


Asp Ser Lys Glu Tyr Val Ala Ala Gln Leu Arg Gln Leu Pro Ala Gln 
                165                 170                 175     


Pro Pro Glu His Ala Val Asp Gly Glu Gly Phe Lys Asn Thr Leu Glu 
            180                 185                 190         


Thr Ser Ser Leu Asn Phe Lys Val Thr Pro Asp Ile Glu Glu Ser Leu 
        195                 200                 205             


Leu Glu Pro Glu Asn Glu Lys Ile Leu Asp Ile Leu Gly Glu Thr Cys 
    210                 215                 220                 


Lys Ser Glu Pro Val Lys Glu Glu Ser Ser Glu Leu Glu Gln Pro Phe 
225                 230                 235                 240 


Ala Gln Asp Thr Ser Ser Val Gly Pro Asp Arg Lys Leu Ala Glu Glu 
                245                 250                 255     


Glu Asp Leu Phe Asp Ser Ala His Pro Glu Glu Gly Asp Leu Asp Leu 
            260                 265                 270         


Ala Ser Glu Ser Thr Ala His Ala Gln Ser Ser Lys Ala Asp Ser Leu 
        275                 280                 285             


Leu Ala Val Val Lys Arg Glu Pro Ala Glu Gln Pro Gly Asp Gly Glu 
    290                 295                 300                 


Arg Thr Asp Cys Glu Pro Val Gly Leu Glu Pro Ala Val Glu Gln Ser 
305                 310                 315                 320 


Ser Ala Ala Ser Glu Leu Ala Glu Ala Ser Ser Glu Glu Leu Ala Glu 
                325                 330                 335     


Ala Pro Thr Glu Ala Pro Ser Pro Glu Ala Arg Asp Ser Lys Glu Asp 
            340                 345                 350         


Gly Arg Lys Phe Asp Phe Asp Ala Cys Asn Glu Val Pro Pro Ala Pro 
        355                 360                 365             


Lys Glu Ser Ser Thr Ser Glu Gly Ala Asp Gln Lys Met Ser Ser Phe 
    370                 375                 380                 


Lys Glu Glu Lys Asp Ile Lys Pro Ile Ile Lys Asp Glu Lys Gly Arg 
385                 390                 395                 400 


Val Gly Ser Gly Ser Gly Arg Asn Leu Trp Val Ser Gly Leu Ser Ser 
                405                 410                 415     


Thr Thr Arg Ala Thr Asp Leu Lys Asn Leu Phe Ser Lys Tyr Gly Lys 
            420                 425                 430         


Val Val Gly Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Arg 
        435                 440                 445             


Cys Tyr Gly Phe Val Thr Met Ser Thr Ser Asp Glu Ala Thr Lys Cys 
    450                 455                 460                 


Ile Ser His Leu His Arg Thr Glu Leu His Gly Arg Met Ile Ser Val 
465                 470                 475                 480 


Glu Lys Ala Lys Asn Glu Pro Ala Gly Lys Lys Leu Ser Asp Arg Lys 
                485                 490                 495     


Glu Cys Glu Val Lys Lys Glu Lys Leu Ser Ser Val Asp Arg His His 
            500                 505                 510         


Ser Val Glu Ile Lys Ile Glu Lys Thr Val Ile Lys Lys Glu Glu Lys 
        515                 520                 525             


Ile Glu Lys Lys Glu Glu Lys Lys Pro Glu Asp Ile Lys Lys Glu Glu 
    530                 535                 540                 


Lys Asp Gln Asp Glu Leu Lys Pro Gly Pro Thr Asn Arg Ser Arg Val 
545                 550                 555                 560 


Thr Lys Ser Gly Ser Arg Gly Met Glu Arg Thr Val Val Met Asp Lys 
                565                 570                 575     


Ser Lys Gly Glu Pro Val Ile Ser Val Lys Thr Thr Ser Arg Ser Lys 
            580                 585                 590         


Glu Arg Ser Ser Lys Ser Gln Asp Arg Lys Ser Glu Ser Lys Glu Lys 
        595                 600                 605             


Arg Asp Ile Leu Ser Phe Asp Lys Ile Lys Glu Gln Arg Glu Arg Glu 
    610                 615                 620                 


Arg Gln Arg Gln Arg Glu Arg Glu Ile Arg Glu Thr Glu Arg Arg Arg 
625                 630                 635                 640 


Glu Arg Glu Gln Arg Glu Arg Glu Gln Arg Leu Glu Ala Phe His Glu 
                645                 650                 655     


Arg Lys Glu Lys Ala Arg Leu Gln Arg Glu Arg Leu Gln Leu Glu Cys 
            660                 665                 670         


Gln Arg Gln Arg Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu 
        675                 680                 685             


Arg Glu Arg Met Arg Val Glu Arg Glu Arg Arg Lys Glu Gln Glu Arg 
    690                 695                 700                 


Ile His Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Glu Gln Leu Arg 
705                 710                 715                 720 


Tyr Glu Gln Glu Arg Arg Pro Gly Arg Arg Pro Tyr Asp Leu Asp Arg 
                725                 730                 735     


Arg Asp Asp Ala Tyr Trp Pro Glu Gly Lys Arg Val Ala Met Glu Asp 
            740                 745                 750         


Arg Tyr Arg Ala Asp Phe Pro Arg Pro Asp His Arg Phe His Asp Phe 
        755                 760                 765             


Asp His Arg Asp Arg Gly Gln Tyr Gln Asp His Ala Ile Asp Arg Arg 
    770                 775                 780                 


Glu Gly Ser Arg Pro Met Met Gly Asp His Arg Asp Gly Gln His Tyr 
785                 790                 795                 800 


Gly Asp Asp Arg His Gly His Gly Gly Pro Pro Glu Arg His Gly Arg 
                805                 810                 815     


Asp Ser Arg Asp Gly Trp Gly Gly Tyr Gly Ser Asp Lys Arg Leu Ser 
            820                 825                 830         


Glu Gly Arg Gly Leu Pro Pro Pro Pro Arg Gly Gly Arg Asp Trp Gly 
        835                 840                 845             


Glu His Asn Gln Arg Leu Glu Glu His Gln Ala Arg Ala Trp Gln Gly 
    850                 855                 860                 


Ala Met Asp Ala Gly Ala Ala Ser Arg Glu His Ala Arg Trp Gln Gly 
865                 870                 875                 880 


Gly Glu Arg Gly Leu Ser Gly Pro Ser Gly Pro Gly His Met Ala Ser 
                885                 890                 895     


Arg Gly Gly Val Ala Gly Arg Gly Gly Phe Ala Gln Gly Gly His Ser 
            900                 905                 910         


Gln Gly His Val Val Pro Gly Gly Gly Leu Glu Gly Gly Gly Val Ala 
        915                 920                 925             


Ser Gln Asp Arg Gly Ser Arg Val Pro His Pro His Pro His Pro Pro 
    930                 935                 940                 


Pro Tyr Pro His Phe Thr Arg Arg Tyr 
945                 950             


<210>  915
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  915

Met Asp His Leu Asn Glu Ala Thr Gln Gly Lys Glu His Ser Glu Met 
1               5                   10                  15      


Ser Asn Asn Val Ser Asp Pro Lys Gly Pro Pro Ala Lys Ile Ala Arg 
            20                  25                  30          


Leu Glu Gln Asn Gly Ser Pro Leu Gly Arg Gly Arg Leu Gly Ser Thr 
        35                  40                  45              


Gly Ala Lys Met Gln Gly Val Pro Leu Lys His Ser Gly His Leu Met 
    50                  55                  60                  


Lys Thr Asn Leu Arg Lys Gly Thr Met Leu Pro Val Phe Cys Val Val 
65                  70                  75                  80  


Glu His Tyr Glu Asn Ala Ile Glu Tyr Asp Cys Lys Glu Glu His Ala 
                85                  90                  95      


Glu Phe Val Leu Val Arg Lys Asp Met Leu Phe Asn Gln Leu Ile Glu 
            100                 105                 110         


Met Ala Leu Leu Ser Leu Gly Tyr Ser His Ser Ser Ala Ala Gln Ala 
        115                 120                 125             


Lys Gly Leu Ile Gln Val Gly Lys Trp Asn Pro Val Pro Leu Ser Tyr 
    130                 135                 140                 


Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln Asp Val 
145                 150                 155                 160 


Tyr His Val Val Thr Leu Lys Ile Gln Leu His Ser Cys Pro Lys Leu 
                165                 170                 175     


Glu Asp Leu Pro Pro Glu Gln Trp Ser His Thr Thr Val Arg Asn Ala 
            180                 185                 190         


Leu Lys Asp Leu Leu Lys Asp Met Asn Gln Ser Ser Leu Ala Lys Glu 
        195                 200                 205             


Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser Thr Tyr 
    210                 215                 220                 


Tyr Ala Asn Val Ser Ala Ala Lys Cys Gln Glu Phe Gly Arg Trp Tyr 
225                 230                 235                 240 


Lys His Phe Lys Lys Thr Lys Asp Met Met Val Glu Met Asp Ser Leu 
                245                 250                 255     


Ser Glu Leu Ser Gln Gln Gly Ala Asn His Val Asn Phe Gly Gln Gln 
            260                 265                 270         


Pro Val Pro Gly Asn Thr Ala Glu Gln Pro Pro Ser Pro Ala Gln Leu 
        275                 280                 285             


Ser His Gly Ser Gln Pro Ser Val Arg Thr Pro Leu Pro Asn Leu His 
    290                 295                 300                 


Pro Gly Leu Val Ser Thr Pro Ile Ser Pro Gln Leu Val Asn Gln Gln 
305                 310                 315                 320 


Leu Val Met Ala Gln Leu Leu Asn Gln Gln Tyr Ala Val Asn Arg Leu 
                325                 330                 335     


Leu Ala Gln Gln Ser Leu Asn Gln Gln Tyr Leu Asn His Pro Pro Pro 
            340                 345                 350         


Val Ser Arg Ser Met Asn Lys Pro Leu Glu Gln Gln Val Ser Thr Asn 
        355                 360                 365             


Thr Glu Val Ser Ser Glu Ile Tyr Gln Trp Val Arg Asp Glu Leu Lys 
    370                 375                 380                 


Arg Ala Gly Ile Ser Gln Ala Val Phe Ala Arg Val Ala Phe Asn Arg 
385                 390                 395                 400 


Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro Lys 
                405                 410                 415     


Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg Ala Met Gln Asn Phe 
            420                 425                 430         


Leu Gln Leu Pro Glu Ala Glu Arg Asp Arg Ile Tyr Gln Asp Glu Arg 
        435                 440                 445             


Glu Arg Ser Leu Asn Ala Ala Ser Ala Met Gly Pro Ala Pro Leu Ile 
    450                 455                 460                 


Ser Thr Pro Pro Ser Arg Pro Pro Gln Val Lys Thr Ala Thr Ile Ala 
465                 470                 475                 480 


Thr Glu Arg Asn Gly Lys Pro Glu Asn Asn Thr Met Asn Ile Asn Ala 
                485                 490                 495     


Ser Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg Ala Lys Val Ser 
            500                 505                 510         


Gln Ala Leu Phe Ala Lys Val Ala Ala Thr Lys Ser Gln Gly Trp Leu 
        515                 520                 525             


Cys Glu Leu Leu Arg Trp Lys Glu Asp Pro Ser Pro Glu Asn Arg Thr 
    530                 535                 540                 


Leu Trp Glu Asn Leu Ser Met Ile Arg Arg Phe Leu Ser Leu Pro Gln 
545                 550                 555                 560 


Pro Glu Arg Asp Ala Ile Tyr Glu Gln Glu Ser Asn Ala Val His His 
                565                 570                 575     


His Gly Asp Arg Pro Pro His Ile Ile His Val Pro Ala Glu Gln Ile 
            580                 585                 590         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
        595                 600                 605             


Pro Pro Pro Pro Gln Pro Gln Gln Gln Pro Gln Thr Gly Pro Arg Leu 
    610                 615                 620                 


Pro Pro Arg Gln Pro Thr Val Ala Ser Pro Ala Glu Ser Asp Glu Glu 
625                 630                 635                 640 


Asn Arg Gln Lys Thr Arg Pro Arg Thr Lys Ile Ser Val Glu Ala Leu 
                645                 650                 655     


Gly Ile Leu Gln Ser Phe Ile Gln Asp Val Gly Leu Tyr Pro Asp Glu 
            660                 665                 670         


Glu Ala Ile Gln Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys Tyr Thr 
        675                 680                 685             


Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr Tyr Leu Lys His His Gly 
    690                 695                 700                 


Lys Leu Lys Asp Asn Ser Gly Leu Glu Val Asp Val Ala Glu Tyr Lys 
705                 710                 715                 720 


Glu Glu Glu Leu Leu Lys Asp Leu Glu Glu Ser Val Gln Asp Lys Asn 
                725                 730                 735     


Thr Asn Thr Leu Phe Ser Val Lys Leu Glu Glu Glu Leu Ser Val Glu 
            740                 745                 750         


Gly Asn Thr Asp Ile Asn Thr Asp Leu Lys Asp 
        755                 760             


<210>  916
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  916

Met Ala Glu Arg Arg Arg His Lys Lys Arg Ile Gln Glu Val Gly Glu 
1               5                   10                  15      


Pro Ser Lys Glu Glu Lys Ala Val Ala Lys Tyr Leu Arg Phe Asn Cys 
            20                  25                  30          


Pro Thr Lys Ser Thr Asn Met Met Gly His Arg Val Asp Tyr Phe Ile 
        35                  40                  45              


Ala Ser Lys Ala Val Asp Cys Leu Leu Asp Ser Lys Trp Ala Lys Ala 
    50                  55                  60                  


Lys Lys Gly Glu Glu Ala Leu Phe Thr Thr Arg Glu Ser Val Val Asp 
65                  70                  75                  80  


Tyr Cys Asn Arg Leu Leu Lys Lys Gln Phe Phe His Arg Ala Leu Lys 
                85                  90                  95      


Val Met Lys Met Lys Tyr Asp Lys Asp Ile Lys Lys Glu Lys Asp Lys 
            100                 105                 110         


Gly Lys Ala Glu Ser Gly Lys Glu Glu Asp Lys Lys Ser Lys Lys Glu 
        115                 120                 125             


Asn Ile Lys Asp Glu Lys Thr Lys Lys Glu Lys Glu Lys Lys Lys Asp 
    130                 135                 140                 


Gly Glu Lys Glu Glu Ser Lys Lys Glu Glu Thr Pro Gly Thr Pro Lys 
145                 150                 155                 160 


Lys Lys Glu Thr Lys Lys Lys Phe Lys Leu Glu Pro His Asp Asp Gln 
                165                 170                 175     


Val Phe Leu Asp Gly Asn Glu Val Tyr Val Trp Ile Tyr Asp Pro Val 
            180                 185                 190         


His Phe Lys Thr Phe Val Met Gly Leu Ile Leu Val Ile Ala Val Ile 
        195                 200                 205             


Ala Ala Thr Leu Phe Pro Leu Trp Pro Ala Glu Met Arg Val Gly Val 
    210                 215                 220                 


Tyr Tyr Leu Ser Val Gly Ala Gly Cys Phe Val Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Leu Ala Val Ala Arg Cys Ile Leu Phe Leu Ile Ile Trp Leu Ile Thr 
                245                 250                 255     


Gly Gly Arg His His Phe Trp Phe Leu Pro Asn Leu Thr Ala Asp Val 
            260                 265                 270         


Gly Phe Ile Asp Ser Phe Arg Pro Leu Tyr Thr His Glu Tyr Lys Gly 
        275                 280                 285             


Pro Lys Ala Asp Leu Lys Lys Asp Glu Lys Ser Glu Thr Lys Lys Gln 
    290                 295                 300                 


Gln Lys Ser Asp Ser Glu Glu Lys Ser Asp Ser Glu Lys Lys Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Lys Val Gly Pro Gly Asn His Gly Thr Glu Gly Ser Gly 
                325                 330                 335     


Gly Glu Arg His Ser Asp Thr Asp Ser Asp Arg Arg Glu Asp Asp Arg 
            340                 345                 350         


Ser Gln His Ser Ser Gly Asn Gly Asn Asp Phe Glu Met Ile Thr Lys 
        355                 360                 365             


Glu Glu Leu Glu Gln Gln Thr Asp Gly Asp Cys Glu Glu Asp Glu Glu 
    370                 375                 380                 


Glu Glu Asn Asp Gly Glu Thr Pro Lys Ser Ser His Glu Lys Ser 
385                 390                 395                 


<210>  917
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  917

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  918
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  918

Met Gly Ala Val Leu Gly Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
1               5                   10                  15      


Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Asn Ser 
            20                  25                  30          


Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Leu Leu 
        35                  40                  45              


Ser Thr Val Val Ser Tyr Ile Met Gln Arg Lys Glu Met Glu Thr Tyr 
    50                  55                  60                  


Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Lys Ile His Glu 
65                  70                  75                  80  


Ala Asp Ile Asn Ala Asp Lys Asp Cys Asp Val Leu Val Gly Tyr Lys 
                85                  90                  95      


Ala Val Tyr Arg Ile Ser Phe Ala Met Ala Ile Phe Phe Phe Val Phe 
            100                 105                 110         


Ser Leu Leu Met Phe Lys Val Lys Thr Ser Lys Asp Leu Arg Ala Ala 
        115                 120                 125             


Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Leu Ile Gly Ile 
    130                 135                 140                 


Met Val Gly Ser Phe Tyr Ile Pro Gly Gly Tyr Phe Ser Ser Val Trp 
145                 150                 155                 160 


Phe Val Val Gly Met Ile Gly Ala Ala Leu Phe Ile Leu Ile Gln Leu 
                165                 170                 175     


Val Leu Leu Val Asp Phe Ala His Ser Trp Asn Glu Ser Trp Val Asn 
            180                 185                 190         


Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
        195                 200                 205             


Phe Thr Ser Ala Phe Tyr Ile Leu Ser Ile Ile Cys Val Gly Leu Leu 
    210                 215                 220                 


Tyr Thr Tyr Tyr Thr Lys Pro Asp Gly Cys Thr Glu Asn Lys Phe Phe 
225                 230                 235                 240 


Ile Ser Ile Asn Leu Ile Leu Cys Val Val Ala Ser Ile Ile Ser Ile 
                245                 250                 255     


His Pro Lys Ile Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
            260                 265                 270         


Ser Leu Ile Thr Leu Tyr Thr Met Tyr Leu Thr Trp Ser Ala Met Ser 
        275                 280                 285             


Asn Glu Pro Asp Arg Ser Cys Asn Pro Asn Leu Met Ser Phe Ile Thr 
    290                 295                 300                 


Arg Ile Thr Ala Pro Thr Leu Ala Pro Gly Asn Ser Thr Ala Val Val 
305                 310                 315                 320 


Pro Thr Pro Thr Pro Pro Ser Lys Ser Gly Ser Leu Leu Asp Ser Asp 
                325                 330                 335     


Asn Phe Ile Gly Leu Phe Val Phe Val Leu Cys Leu Leu Tyr Ser Ser 
            340                 345                 350         


Ile Arg Thr Ser Thr Asn Ser Gln Val Asp Lys Leu Thr Leu Ser Gly 
        355                 360                 365             


Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Thr Ser Gly Ala Ser Asp 
    370                 375                 380                 


Glu Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly 
385                 390                 395                 400 


Val Gln Tyr Ser Tyr Ser Leu Phe His Leu Met Leu Cys Leu Ala Ser 
                405                 410                 415     


Leu Tyr Ile Met Met Thr Leu Thr Ser Trp Tyr Ser Pro Asp Ala Lys 
            420                 425                 430         


Phe Gln Ser Met Thr Ser Lys Trp Pro Ala Val Trp Val Lys Ile Ser 
        435                 440                 445             


Ser Ser Trp Val Cys Leu Leu Leu Tyr Val Trp Thr Leu Val Ala Pro 
    450                 455                 460                 


Leu Val Leu Thr Ser Arg Asp Phe Ser 
465                 470             


<210>  919
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  919

Met Ser Ala Gln Cys Cys Ala Gly Gln Leu Ala Cys Cys Cys Gly Ser 
1               5                   10                  15      


Ala Gly Cys Ser Leu Cys Cys Asp Cys Cys Pro Arg Ile Arg Gln Ser 
            20                  25                  30          


Leu Ser Thr Arg Phe Met Tyr Ala Leu Tyr Phe Ile Leu Val Val Val 
        35                  40                  45              


Leu Cys Cys Ile Met Met Ser Thr Thr Val Ala His Lys Met Lys Glu 
    50                  55                  60                  


His Ile Pro Phe Phe Glu Asp Met Cys Lys Gly Ile Lys Ala Gly Asp 
65                  70                  75                  80  


Thr Cys Glu Lys Leu Val Gly Tyr Ser Ala Val Tyr Arg Val Cys Phe 
                85                  90                  95      


Gly Met Ala Cys Phe Phe Phe Ile Phe Cys Leu Leu Thr Leu Lys Ile 
            100                 105                 110         


Asn Asn Ser Lys Ser Cys Arg Ala His Ile His Asn Gly Phe Trp Phe 
        115                 120                 125             


Phe Lys Leu Leu Leu Leu Gly Ala Met Cys Ser Gly Ala Phe Phe Ile 
    130                 135                 140                 


Pro Asp Gln Asp Thr Phe Leu Asn Ala Trp Arg Tyr Val Gly Ala Val 
145                 150                 155                 160 


Gly Gly Phe Leu Phe Ile Gly Ile Gln Leu Leu Leu Leu Val Glu Phe 
                165                 170                 175     


Ala His Lys Trp Asn Lys Asn Trp Thr Ala Gly Thr Ala Ser Asn Lys 
            180                 185                 190         


Leu Trp Tyr Ala Ser Leu Ala Leu Val Thr Leu Ile Met Tyr Ser Ile 
        195                 200                 205             


Ala Thr Gly Gly Leu Val Leu Met Ala Val Phe Tyr Thr Gln Lys Asp 
    210                 215                 220                 


Ser Cys Met Glu Asn Lys Ile Leu Leu Gly Val Asn Gly Gly Leu Cys 
225                 230                 235                 240 


Leu Leu Ile Ser Leu Val Ala Ile Ser Pro Trp Val Gln Asn Arg Gln 
                245                 250                 255     


Pro His Ser Gly Leu Leu Gln Ser Gly Val Ile Ser Cys Tyr Val Thr 
            260                 265                 270         


Tyr Leu Thr Phe Ser Ala Leu Ser Ser Lys Pro Ala Glu Val Asp Glu 
        275                 280                 285             


His Gly Lys Asn Val Thr Ile Cys Val Pro Asp Phe Gly Gln Asp Leu 
    290                 295                 300                 


Tyr Arg Asp Glu Asn Leu Val Thr Ile Leu Gly Thr Ser Leu Leu Ile 
305                 310                 315                 320 


Gly Cys Ile Leu Tyr Ser Cys Leu Thr Ser Thr Thr Arg Ser Ser Ser 
                325                 330                 335     


Asp Ala Leu Gln Gly Arg Tyr Ala Ala Pro Glu Leu Glu Ile Ala Arg 
            340                 345                 350         


Cys Cys Phe Cys Phe Ser Pro Gly Gly Glu Asp Thr Glu Glu Gln Gln 
        355                 360                 365             


Pro Gly Lys Glu Gly Pro Arg Val Ile Tyr Asp Glu Lys Lys Gly Thr 
    370                 375                 380                 


Val Tyr Ile Tyr Ser Tyr Phe His Phe Val Phe Phe Leu Ala Ser Leu 
385                 390                 395                 400 


Tyr Val Met Met Thr Val Thr Asn Trp Phe Lys Trp Ser Pro Thr Leu 
                405                 410                 415     


Leu Pro Arg Leu Glu Tyr Ser Gly Met Ile Leu Ala His Cys Asn Leu 
            420                 425                 430         


His Leu Pro Asp Val Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser 
        435                 440                 445             


Trp Gly Tyr Arg His Val Pro Pro 
    450                 455     


<210>  920
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  920

Met Leu Gly Lys Gly Gly Lys Arg Lys Phe Asp Glu His Glu Asp Gly 
1               5                   10                  15      


Leu Glu Gly Lys Ile Val Ser Pro Cys Asp Gly Pro Ser Lys Val Ser 
            20                  25                  30          


Tyr Thr Leu Gln Arg Gln Thr Ile Phe Asn Ile Ser Leu Met Lys Leu 
        35                  40                  45              


Tyr Asn His Arg Pro Leu Thr Glu Pro Ser Leu Gln Lys Thr Val Leu 
    50                  55                  60                  


Ile Asn Asn Met Leu Arg Arg Ile Gln Glu Glu Leu Lys Gln Glu Gly 
65                  70                  75                  80  


Ser Leu Arg Pro Met Phe Thr Pro Ser Ser Gln Pro Thr Thr Glu Pro 
                85                  90                  95      


Ser Asp Ser Tyr Arg Glu Ala Pro Pro Ala Phe Ser His Leu Ala Ser 
            100                 105                 110         


Pro Ser Ser His Pro Cys Asp Leu Gly Ser Thr Thr Pro Leu Glu Ala 
        115                 120                 125             


Cys Leu Thr Pro Ala Ser Leu Leu Glu Asp Asp Asp Asp Thr Phe Cys 
    130                 135                 140                 


Thr Ser Gln Ala Met Gln Pro Thr Ala Pro Thr Lys Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Leu Leu Pro Glu Lys Asp Ser Phe Ser Ser Ala Leu Asp Glu Ile 
                165                 170                 175     


Glu Glu Leu Cys Pro Thr Ser Thr Ser Thr Glu Ala Ala Thr Ala Ala 
            180                 185                 190         


Thr Asp Ser Val Lys Gly Thr Ser Ser Glu Ala Gly Thr Gln Lys Leu 
        195                 200                 205             


Asp Gly Pro Gln Glu Ser Arg Ala Asp Asp Ser Lys Leu Met Asp Ser 
    210                 215                 220                 


Leu Pro Gly Asn Phe Glu Ile Thr Thr Ser Thr Gly Phe Leu Thr Asp 
225                 230                 235                 240 


Leu Thr Leu Asp Asp Ile Leu Phe Ala Asp Ile Asp Thr Ser Met Tyr 
                245                 250                 255     


Asp Phe Asp Pro Cys Thr Ser Ser Ser Gly Thr Ala Ser Lys Met Ala 
            260                 265                 270         


Pro Val Ser Ala Asp Asp Leu Leu Lys Thr Leu Ala Pro Tyr Ser Ser 
        275                 280                 285             


Gln Pro Val Thr Pro Ser Gln Pro Phe Lys Met Asp Leu Thr Glu Leu 
    290                 295                 300                 


Asp His Ile Met Glu Val Leu Val Gly Ser 
305                 310                 


<210>  921
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  921

Met Ala Glu Gly Glu Asn Glu Val Arg Trp Asp Gly Leu Cys Ser Arg 
1               5                   10                  15      


Asp Ser Thr Thr Arg Glu Thr Ala Leu Glu Asn Ile Arg Gln Thr Ile 
            20                  25                  30          


Leu Arg Lys Thr Glu Tyr Leu Arg Ser Val Lys Glu Thr Pro His Arg 
        35                  40                  45              


Pro Ser Asp Gly Leu Ser Asn Thr Glu Ser Ser Asp Gly Leu Asn Lys 
    50                  55                  60                  


Leu Leu Ala His Leu Leu Met Leu Ser Lys Arg Cys Pro Phe Lys Asp 
65                  70                  75                  80  


Val Arg Glu Lys Ser Glu Phe Ile Leu Lys Ser Ile Gln Glu Leu Gly 
                85                  90                  95      


Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro Ser Arg Phe Ile Pro 
            100                 105                 110         


Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp Ala Gln Met His Ala 
        115                 120                 125             


Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp Asn Ile Thr 
    130                 135                 140                 


Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe Leu Lys Thr 
145                 150                 155                 160 


Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu His Tyr Arg 
                165                 170                 175     


His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu 
            180                 185                 190         


Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly Asp Pro Lys 
        195                 200                 205             


Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln Asn Leu Gly 
    210                 215                 220                 


Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu 
225                 230                 235                 240 


His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp Ser Leu Ala 
                245                 250                 255     


Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His Ser Leu Ala 
            260                 265                 270         


Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His Cys Asp Gly 
        275                 280                 285             


Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys Ile Cys Asp 
    290                 295                 300                 


Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val Asn Ser Ala 
305                 310                 315                 320 


Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu Ala Leu Met 
                325                 330                 335     


Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu Glu Ala Ser 
            340                 345                 350         


Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg Glu Ser Met 
        355                 360                 365             


Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala Arg Ala Val 
    370                 375                 380                 


Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp Phe Ser Arg 
385                 390                 395                 400 


His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr Cys Trp Glu 
                405                 410                 415     


Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp Val Gly Gln 
            420                 425                 430         


Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr Tyr Asn Thr 
        435                 440                 445             


Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg Arg Ala Ile 
    450                 455                 460                 


Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr Asp 
465                 470                 475                 480 


Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys Val Tyr Ile 
                485                 490                 495     


Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg Met Tyr Asp 
            500                 505                 510         


Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn Leu 
        515                 520                 525             


Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu Arg 
    530                 535                 540                 


Ala Ile Thr Arg Tyr Met Thr 
545                 550     


<210>  922
<211>  2564
<212>  PRT
<213>  Homo sapiens

<400>  922

Met Lys Gln Leu Gln Pro Gln Pro Pro Pro Lys Met Gly Asp Phe Tyr 
1               5                   10                  15      


Asp Pro Glu His Pro Thr Pro Glu Glu Glu Glu Asn Glu Ala Lys Ile 
            20                  25                  30          


Glu Asn Val Gln Lys Thr Gly Phe Ile Lys Gly Pro Met Phe Lys Gly 
        35                  40                  45              


Val Ala Ser Ser Arg Phe Leu Pro Lys Gly Thr Lys Thr Lys Val Asn 
    50                  55                  60                  


Leu Glu Glu Gln Gly Arg Gln Lys Val Ser Phe Ser Phe Ser Leu Thr 
65                  70                  75                  80  


Lys Lys Thr Leu Gln Asn Arg Phe Leu Thr Ala Leu Gly Asn Glu Lys 
                85                  90                  95      


Gln Ser Asp Thr Pro Asn Pro Pro Ala Val Pro Leu Gln Val Asp Ser 
            100                 105                 110         


Thr Pro Lys Met Lys Met Glu Ile Gly Asp Thr Leu Ser Thr Ala Glu 
        115                 120                 125             


Glu Ser Ser Pro Pro Lys Ser Arg Val Glu Leu Gly Lys Ile His Phe 
    130                 135                 140                 


Lys Lys His Leu Leu His Val Thr Ser Arg Pro Leu Leu Ala Thr Thr 
145                 150                 155                 160 


Thr Ala Val Ala Ser Pro Pro Thr His Ala Ala Pro Leu Pro Ala Val 
                165                 170                 175     


Ile Ala Glu Ser Thr Thr Val Asp Ser Pro Pro Ser Ser Pro Pro Pro 
            180                 185                 190         


Pro Pro Pro Pro Ala Gln Ala Thr Thr Leu Ser Ser Pro Ala Pro Val 
        195                 200                 205             


Thr Glu Pro Val Ala Leu Pro His Thr Pro Ile Thr Val Leu Met Ala 
    210                 215                 220                 


Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu Lys Glu 
225                 230                 235                 240 


Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr Lys Gln 
                245                 250                 255     


Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile Leu Asn 
            260                 265                 270         


Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile Gly Lys 
        275                 280                 285             


Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys Lys Lys 
    290                 295                 300                 


Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe Leu Gly 
305                 310                 315                 320 


Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln Arg Ser 
                325                 330                 335     


His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp Phe Lys 
            340                 345                 350         


Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro Ser Arg 
        355                 360                 365             


Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys Leu Glu 
    370                 375                 380                 


Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg Glu Arg 
385                 390                 395                 400 


Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg Thr Asn 
                405                 410                 415     


Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser Asp Arg 
            420                 425                 430         


Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr Ser Arg 
        435                 440                 445             


Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu Glu Glu 
    450                 455                 460                 


Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser Ser Tyr 
465                 470                 475                 480 


Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp Cys Lys 
                485                 490                 495     


Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr Ser Ser 
            500                 505                 510         


Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala Ile Lys 
        515                 520                 525             


Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly Ser Ser 
    530                 535                 540                 


Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr Leu Ser 
545                 550                 555                 560 


Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys Cys Thr 
                565                 570                 575     


Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu Gln Thr 
            580                 585                 590         


Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn Pro Glu 
        595                 600                 605             


Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn Asp Ser 
    610                 615                 620                 


Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser Glu Phe 
625                 630                 635                 640 


Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser Leu Ser 
                645                 650                 655     


Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu Leu Asn 
            660                 665                 670         


Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe Cys Thr 
        675                 680                 685             


Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val Thr Gly 
    690                 695                 700                 


Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser Asn Gly 
705                 710                 715                 720 


Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp Thr Cys 
                725                 730                 735     


Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu Pro Leu 
            740                 745                 750         


Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met Thr Val 
        755                 760                 765             


Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg Val Ser 
    770                 775                 780                 


Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn Asp Ser 
785                 790                 795                 800 


Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro Ser Val 
                805                 810                 815     


Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu Ser Lys 
            820                 825                 830         


Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys Phe Ala 
        835                 840                 845             


Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala Ser Val 
    850                 855                 860                 


Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly Ile Ala 
865                 870                 875                 880 


Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser Leu Thr 
                885                 890                 895     


Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala Val Leu 
            900                 905                 910         


Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys Glu Thr 
        915                 920                 925             


Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly Phe Ala 
    930                 935                 940                 


Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys Leu Gln 
945                 950                 955                 960 


Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg Gly Arg 
                965                 970                 975     


Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val His Thr 
            980                 985                 990         


Ser Asp Asp Ser Glu Val Val Phe  Ser Ser Cys Asp Leu  Asn Leu Thr 
        995                 1000                 1005             


Met Glu  Asp Ser Asp Gly Val  Thr Tyr Ala Leu Lys  Cys Asp Ser 
    1010                 1015                 1020             


Ser Gly  His Ala Pro Glu Ile  Val Ser Thr Val His  Glu Asp Tyr 
    1025                 1030                 1035             


Ser Gly  Ser Ser Glu Ser Ser  Asn Asp Glu Ser Asp  Ser Glu Asp 
    1040                 1045                 1050             


Thr Asp  Ser Asp Asp Ser Ser  Ile Pro Arg Asn Arg  Leu Gln Ser 
    1055                 1060                 1065             


Val Val  Val Val Pro Lys Asn  Ser Thr Leu Pro Met  Glu Glu Thr 
    1070                 1075                 1080             


Ser Pro  Cys Ser Ser Arg Ser  Ser Gln Ser Tyr Arg  His Tyr Ser 
    1085                 1090                 1095             


Asp His  Trp Glu Asp Glu Arg  Leu Glu Ser Arg Arg  His Leu Tyr 
    1100                 1105                 1110             


Glu Glu  Lys Phe Glu Ser Ile  Ala Ser Lys Ala Cys  Pro Gln Thr 
    1115                 1120                 1125             


Asp Lys  Phe Phe Leu His Lys  Gly Thr Glu Lys Asn  Pro Glu Ile 
    1130                 1135                 1140             


Ser Phe  Thr Gln Ser Ser Arg  Lys Gln Ile Asp Asn  Arg Leu Pro 
    1145                 1150                 1155             


Glu Leu  Ser His Pro Gln Ser  Asp Gly Val Asp Ser  Thr Ser His 
    1160                 1165                 1170             


Thr Asp  Val Lys Ser Asp Pro  Leu Gly His Pro Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Val  Lys Ala Lys Ile Pro  Ser Arg Gln Gln Glu  Glu Leu Pro 
    1190                 1195                 1200             


Ile Tyr  Ser Ser Asp Phe Glu  Asp Val Pro Asn Lys  Ser Trp Gln 
    1205                 1210                 1215             


Gln Thr  Thr Phe Gln Asn Arg  Pro Asp Ser Arg Leu  Gly Lys Thr 
    1220                 1225                 1230             


Glu Leu  Ser Phe Ser Ser Ser  Cys Glu Ile Pro His  Val Asp Gly 
    1235                 1240                 1245             


Leu His  Ser Ser Glu Glu Leu  Arg Asn Leu Gly Trp  Asp Phe Ser 
    1250                 1255                 1260             


Gln Glu  Lys Pro Ser Thr Thr  Tyr Gln Gln Pro Asp  Ser Ser Tyr 
    1265                 1270                 1275             


Gly Ala  Cys Gly Gly His Lys  Tyr Gln Gln Asn Ala  Glu Gln Tyr 
    1280                 1285                 1290             


Gly Gly  Thr Arg Asp Tyr Trp  Gln Gly Asn Gly Tyr  Trp Asp Pro 
    1295                 1300                 1305             


Arg Ser  Gly Arg Pro Pro Gly  Thr Gly Val Val Tyr  Asp Arg Thr 
    1310                 1315                 1320             


Gln Gly  Gln Val Pro Asp Ser  Leu Thr Asp Asp Arg  Glu Glu Glu 
    1325                 1330                 1335             


Glu Asn  Trp Asp Gln Gln Asp  Gly Ser His Phe Ser  Asp Gln Ser 
    1340                 1345                 1350             


Asp Lys  Phe Leu Leu Ser Leu  Gln Lys Asp Lys Gly  Ser Val Gln 
    1355                 1360                 1365             


Ala Pro  Glu Ile Ser Ser Asn  Ser Ile Lys Asp Thr  Leu Ala Val 
    1370                 1375                 1380             


Asn Glu  Lys Lys Asp Phe Ser  Lys Asn Leu Glu Lys  Asn Asp Ile 
    1385                 1390                 1395             


Lys Asp  Arg Gly Pro Leu Lys  Lys Arg Arg Gln Glu  Ile Glu Ser 
    1400                 1405                 1410             


Asp Ser  Glu Ser Asp Gly Glu  Leu Gln Asp Arg Lys  Lys Val Arg 
    1415                 1420                 1425             


Val Glu  Val Glu Gln Gly Glu  Thr Ser Val Pro Pro  Gly Ser Ala 
    1430                 1435                 1440             


Leu Val  Gly Pro Ser Cys Val  Met Asp Asp Phe Arg  Asp Pro Gln 
    1445                 1450                 1455             


Arg Trp  Lys Glu Cys Ala Lys  Gln Gly Lys Met Pro  Cys Tyr Phe 
    1460                 1465                 1470             


Asp Leu  Ile Glu Glu Asn Val  Tyr Leu Thr Glu Arg  Lys Lys Asn 
    1475                 1480                 1485             


Lys Ser  His Arg Asp Ile Lys  Arg Met Gln Cys Glu  Cys Thr Pro 
    1490                 1495                 1500             


Leu Ser  Lys Asp Glu Arg Ala  Gln Gly Glu Ile Ala  Cys Gly Glu 
    1505                 1510                 1515             


Asp Cys  Leu Asn Arg Leu Leu  Met Ile Glu Cys Ser  Ser Arg Cys 
    1520                 1525                 1530             


Pro Asn  Gly Asp Tyr Cys Ser  Asn Arg Arg Phe Gln  Arg Lys Gln 
    1535                 1540                 1545             


His Ala  Asp Val Glu Val Ile  Leu Thr Glu Lys Lys  Gly Trp Gly 
    1550                 1555                 1560             


Leu Arg  Ala Ala Lys Asp Leu  Pro Ser Asn Thr Phe  Val Leu Glu 
    1565                 1570                 1575             


Tyr Cys  Gly Glu Val Leu Asp  His Lys Glu Phe Lys  Ala Arg Val 
    1580                 1585                 1590             


Lys Glu  Tyr Ala Arg Asn Lys  Asn Ile His Tyr Tyr  Phe Met Ala 
    1595                 1600                 1605             


Leu Lys  Asn Asp Glu Ile Ile  Asp Ala Thr Gln Lys  Gly Asn Cys 
    1610                 1615                 1620             


Ser Arg  Phe Met Asn His Ser  Cys Glu Pro Asn Cys  Glu Thr Gln 
    1625                 1630                 1635             


Lys Trp  Thr Val Asn Gly Gln  Leu Arg Val Gly Phe  Phe Thr Thr 
    1640                 1645                 1650             


Lys Leu  Val Pro Ser Gly Ser  Glu Leu Thr Phe Asp  Tyr Gln Phe 
    1655                 1660                 1665             


Gln Arg  Tyr Gly Lys Glu Ala  Gln Lys Cys Phe Cys  Gly Ser Ala 
    1670                 1675                 1680             


Asn Cys  Arg Gly Tyr Leu Gly  Gly Glu Asn Arg Val  Ser Ile Arg 
    1685                 1690                 1695             


Ala Ala  Gly Gly Lys Met Lys  Lys Glu Arg Ser Arg  Lys Lys Asp 
    1700                 1705                 1710             


Ser Val  Asp Gly Glu Leu Glu  Ala Leu Met Glu Asn  Gly Glu Gly 
    1715                 1720                 1725             


Leu Ser  Asp Lys Asn Gln Val  Leu Ser Leu Ser Arg  Leu Met Val 
    1730                 1735                 1740             


Arg Ile  Glu Thr Leu Glu Gln  Lys Leu Thr Cys Leu  Glu Leu Ile 
    1745                 1750                 1755             


Gln Asn  Thr His Ser Gln Ser  Cys Leu Lys Ser Phe  Leu Glu Arg 
    1760                 1765                 1770             


His Gly  Leu Ser Leu Leu Trp  Ile Trp Met Ala Glu  Leu Gly Asp 
    1775                 1780                 1785             


Gly Arg  Glu Ser Asn Gln Lys  Leu Gln Glu Glu Ile  Ile Lys Thr 
    1790                 1795                 1800             


Leu Glu  His Leu Pro Ile Pro  Thr Lys Asn Met Leu  Glu Glu Ser 
    1805                 1810                 1815             


Lys Val  Leu Pro Ile Ile Gln  Arg Trp Ser Gln Thr  Lys Thr Ala 
    1820                 1825                 1830             


Val Pro  Pro Leu Ser Glu Gly  Asp Gly Tyr Ser Ser  Glu Asn Thr 
    1835                 1840                 1845             


Ser Arg  Ala His Thr Pro Leu  Asn Thr Pro Asp Pro  Ser Thr Lys 
    1850                 1855                 1860             


Leu Ser  Thr Glu Ala Asp Thr  Asp Thr Pro Lys Lys  Leu Met Phe 
    1865                 1870                 1875             


Arg Arg  Leu Lys Ile Ile Ser  Glu Asn Ser Met Asp  Ser Ala Ile 
    1880                 1885                 1890             


Ser Asp  Ala Thr Ser Glu Leu  Glu Gly Lys Asp Gly  Lys Glu Asp 
    1895                 1900                 1905             


Leu Asp  Gln Leu Glu Asn Val  Pro Val Glu Glu Glu  Glu Glu Leu 
    1910                 1915                 1920             


Gln Ser  Gln Gln Leu Leu Pro  Gln Gln Leu Pro Glu  Cys Lys Val 
    1925                 1930                 1935             


Asp Ser  Glu Thr Asn Ile Glu  Ala Ser Lys Leu Pro  Thr Ser Glu 
    1940                 1945                 1950             


Pro Glu  Ala Asp Ala Glu Ile  Glu Pro Lys Glu Ser  Asn Gly Thr 
    1955                 1960                 1965             


Lys Leu  Glu Glu Pro Ile Asn  Glu Glu Thr Pro Ser  Gln Asp Glu 
    1970                 1975                 1980             


Glu Glu  Gly Val Ser Asp Val  Glu Ser Glu Arg Ser  Gln Glu Gln 
    1985                 1990                 1995             


Pro Asp  Lys Thr Val Asp Ile  Ser Asp Leu Ala Thr  Lys Leu Leu 
    2000                 2005                 2010             


Asp Ser  Trp Lys Asp Leu Lys  Glu Val Tyr Arg Ile  Pro Lys Lys 
    2015                 2020                 2025             


Ser Gln  Thr Glu Lys Glu Asn  Thr Thr Thr Glu Arg  Gly Arg Asp 
    2030                 2035                 2040             


Ala Val  Gly Phe Arg Asp Gln  Thr Pro Ala Pro Lys  Thr Pro Asn 
    2045                 2050                 2055             


Arg Ser  Arg Glu Arg Asp Pro  Asp Lys Gln Thr Gln  Asn Lys Glu 
    2060                 2065                 2070             


Lys Arg  Lys Arg Arg Ser Ser  Leu Ser Pro Pro Ser  Ser Ala Tyr 
    2075                 2080                 2085             


Glu Arg  Gly Thr Lys Arg Pro  Asp Asp Arg Tyr Asp  Thr Pro Thr 
    2090                 2095                 2100             


Ser Lys  Lys Lys Val Arg Ile  Lys Asp Arg Asn Lys  Leu Ser Thr 
    2105                 2110                 2115             


Glu Glu  Arg Arg Lys Leu Phe  Glu Gln Glu Val Ala  Gln Arg Glu 
    2120                 2125                 2130             


Ala Gln  Lys Gln Gln Gln Gln  Met Gln Asn Leu Gly  Met Thr Ser 
    2135                 2140                 2145             


Pro Leu  Pro Tyr Asp Ser Leu  Gly Tyr Asn Ala Pro  His His Pro 
    2150                 2155                 2160             


Phe Ala  Gly Tyr Pro Pro Gly  Tyr Pro Met Gln Ala  Tyr Val Asp 
    2165                 2170                 2175             


Pro Ser  Asn Pro Asn Ala Gly  Lys Val Leu Leu Pro  Thr Pro Ser 
    2180                 2185                 2190             


Met Asp  Pro Val Cys Ser Pro  Ala Pro Tyr Asp His  Ala Gln Pro 
    2195                 2200                 2205             


Leu Val  Gly His Ser Thr Glu  Pro Leu Ser Ala Pro  Pro Pro Val 
    2210                 2215                 2220             


Pro Val  Val Pro His Val Ala  Ala Pro Val Glu Val  Ser Ser Ser 
    2225                 2230                 2235             


Gln Tyr  Val Ala Gln Ser Asp  Gly Val Val His Gln  Asp Ser Ser 
    2240                 2245                 2250             


Val Ala  Val Leu Pro Val Pro  Ala Pro Gly Pro Val  Gln Gly Gln 
    2255                 2260                 2265             


Asn Tyr  Ser Val Trp Asp Ser  Asn Gln Gln Ser Val  Ser Val Gln 
    2270                 2275                 2280             


Gln Gln  Tyr Ser Pro Ala Gln  Ser Gln Ala Thr Ile  Tyr Tyr Gln 
    2285                 2290                 2295             


Gly Gln  Thr Cys Pro Thr Val  Tyr Gly Val Thr Ser  Pro Tyr Ser 
    2300                 2305                 2310             


Gln Thr  Thr Pro Pro Ile Val  Gln Ser Tyr Ala Gln  Pro Ser Leu 
    2315                 2320                 2325             


Gln Tyr  Ile Gln Gly Gln Gln  Ile Phe Thr Ala His  Pro Gln Gly 
    2330                 2335                 2340             


Val Val  Val Gln Pro Ala Ala  Ala Val Thr Thr Ile  Val Ala Pro 
    2345                 2350                 2355             


Gly Gln  Pro Gln Pro Leu Gln  Pro Ser Glu Met Val  Val Thr Asn 
    2360                 2365                 2370             


Asn Leu  Leu Asp Leu Pro Pro  Pro Ser Pro Pro Lys  Pro Lys Thr 
    2375                 2380                 2385             


Ile Val  Leu Pro Pro Asn Trp  Lys Thr Ala Arg Asp  Pro Glu Gly 
    2390                 2395                 2400             


Lys Ile  Tyr Tyr Tyr His Val  Ile Thr Arg Gln Thr  Gln Trp Asp 
    2405                 2410                 2415             


Pro Pro  Thr Trp Glu Ser Pro  Gly Asp Asp Ala Ser  Leu Glu His 
    2420                 2425                 2430             


Glu Ala  Glu Met Asp Leu Gly  Thr Pro Thr Tyr Asp  Glu Asn Pro 
    2435                 2440                 2445             


Met Lys  Ala Ser Lys Lys Pro  Lys Thr Ala Glu Ala  Asp Thr Ser 
    2450                 2455                 2460             


Ser Glu  Leu Ala Lys Lys Ser  Lys Glu Val Phe Arg  Lys Glu Met 
    2465                 2470                 2475             


Ser Gln  Phe Ile Val Gln Cys  Leu Asn Pro Tyr Arg  Lys Pro Asp 
    2480                 2485                 2490             


Cys Lys  Val Gly Arg Ile Thr  Thr Thr Glu Asp Phe  Lys His Leu 
    2495                 2500                 2505             


Ala Arg  Lys Leu Thr His Gly  Val Met Asn Lys Glu  Leu Lys Tyr 
    2510                 2515                 2520             


Cys Lys  Asn Pro Glu Asp Leu  Glu Cys Asn Glu Asn  Val Lys His 
    2525                 2530                 2535             


Lys Thr  Lys Glu Tyr Ile Lys  Lys Tyr Met Gln Lys  Phe Gly Ala 
    2540                 2545                 2550             


Val Tyr  Lys Pro Lys Glu Asp  Thr Glu Leu Glu 
    2555                 2560                 


<210>  923
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  923

Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
1               5                   10                  15      


Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
            20                  25                  30          


His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
        35                  40                  45              


Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
    50                  55                  60                  


Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
65                  70                  75                  80  


Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                85                  90                  95      


Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
            100                 105                 110         


Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
        115                 120                 125             


Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
    130                 135                 140                 


Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
145                 150                 155                 160 


Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                165                 170                 175     


Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
            180                 185                 190         


Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
        195                 200                 205             


Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
    210                 215                 220                 


Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
225                 230                 235                 240 


Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                245                 250                 255     


Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
            260                 265                 270         


Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
        275                 280                 285             


Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
    290                 295                 300                 


Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
305                 310                 315                 320 


Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                325                 330                 335     


Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
            340                 345                 350         


Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
        355                 360                 365             


Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
    370                 375                 380                 


Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
385                 390                 395                 400 


Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                405                 410                 415     


Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
            420                 425                 430         


Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
        435                 440                 445             


Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
    450                 455                 460                 


Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
465                 470                 475                 480 


Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                485                 490                 495     


Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
            500                 505                 510         


Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
        515                 520                 525             


Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
    530                 535                 540                 


Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
545                 550                 555                 560 


Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                565                 570                 575 


<210>  924
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  924

Met Thr Ala Val Gly Arg Arg Cys Pro Ala Leu Gly Ser Arg Gly Ala 
1               5                   10                  15      


Ala Gly Glu Pro Glu Ala Gly Ser Asp Tyr Val Lys Phe Ser Lys Glu 
            20                  25                  30          


Lys Tyr Ile Leu Asp Ser Ser Pro Glu Lys Leu His Lys Glu Leu Glu 
        35                  40                  45              


Glu Glu Leu Lys Leu Ser Ser Thr Asp Leu Arg Ser His Ala Trp Tyr 
    50                  55                  60                  


His Gly Arg Ile Pro Arg Glu Val Ser Glu Thr Leu Val Gln Arg Asn 
65                  70                  75                  80  


Gly Asp Phe Leu Ile Arg Asp Ser Leu Thr Ser Leu Gly Asp Tyr Val 
                85                  90                  95      


Leu Thr Cys Arg Trp Arg Asn Gln Ala Leu His Phe Lys Ile Asn Lys 
            100                 105                 110         


Val Val Val Lys Ala Gly Glu Ser Tyr Thr His Ile Gln Tyr Leu Phe 
        115                 120                 125             


Glu Gln Glu Ser Phe Asp His Val Pro Ala Leu Val Arg Tyr His Val 
    130                 135                 140                 


Gly Ser Arg Lys Ala Val Ser Glu Gln Ser Gly Ala Ile Ile Tyr Cys 
145                 150                 155                 160 


Pro Val Asn Arg Thr Phe Pro Leu Arg Tyr Leu Glu Ala Ser Tyr Gly 
                165                 170                 175     


Leu Gly Gln Gly Ser Ser Lys Pro Ala Ser Pro Val Ser Pro Ser Gly 
            180                 185                 190         


Pro Lys Gly Ser His Met Lys Arg Arg Ser Val Thr Met Thr Asp Gly 
        195                 200                 205             


Leu Thr Ala Asp Lys Val Thr Arg Ser Asp Gly Cys Pro Thr Ser Thr 
    210                 215                 220                 


Ser Leu Pro Arg Pro Arg Asp Ser Ile Arg Ser Cys Ala Leu Ser Met 
225                 230                 235                 240 


Asp Gln Ile Pro Asp Leu His Ser Pro Met Ser Pro Ile Ser Glu Ser 
                245                 250                 255     


Pro Ser Ser Pro Ala Tyr Ser Thr Val Thr Arg Val His Ala Ala Pro 
            260                 265                 270         


Ala Ala Pro Ser Ala Thr Ala Leu Pro Ala Ser Pro Val Ala Arg Arg 
        275                 280                 285             


Ser Ser Glu Pro Gln Leu Cys Pro Gly Ser Ala Pro Lys Thr His Gly 
    290                 295                 300                 


Glu Ser Asp Lys Gly Pro His Thr Ser Pro Ser His Thr Leu Gly Lys 
305                 310                 315                 320 


Ala Ser Pro Ser Pro Ser Leu Ser Ser Tyr Ser Asp Pro Asp Ser Gly 
                325                 330                 335     


His Tyr Cys Gln Leu Gln Pro Pro Val Arg Gly Ser Arg Glu Trp Ala 
            340                 345                 350         


Ala Thr Glu Thr Ser Ser Gln Gln Ala Arg Ser Tyr Gly Glu Arg Leu 
        355                 360                 365             


Lys Glu Leu Ser Glu Asn Gly Ala Pro Glu Gly Asp Trp Gly Lys Thr 
    370                 375                 380                 


Phe Thr Val Pro Ile Val Glu Val Thr Ser Ser Phe Asn Pro Ala Thr 
385                 390                 395                 400 


Phe Gln Ser Leu Leu Ile Pro Arg Asp Asn Arg Pro Leu Glu Val Gly 
                405                 410                 415     


Leu Leu Arg Lys Val Lys Glu Leu Leu Ala Glu Val Asp Ala Arg Thr 
            420                 425                 430         


Leu Ala Arg His Val Thr Lys Val Asp Cys Leu Val Ala Arg Ile Leu 
        435                 440                 445             


Gly Val Thr Lys Glu Met Gln Thr Leu Met Gly Val Arg Trp Gly Met 
    450                 455                 460                 


Glu Leu Leu Thr Leu Pro His Gly Arg Gln Leu Arg Leu Asp Leu Leu 
465                 470                 475                 480 


Glu Arg Phe His Thr Met Ser Ile Met Leu Ala Val Asp Ile Leu Gly 
                485                 490                 495     


Cys Thr Gly Ser Ala Glu Glu Arg Ala Ala Leu Leu His Lys Thr Ile 
            500                 505                 510         


Gln Leu Ala Ala Glu Leu Arg Gly Thr Met Gly Asn Met Phe Ser Phe 
        515                 520                 525             


Ala Ala Val Met Gly Ala Leu Asp Met Ala Gln Ile Ser Arg Leu Glu 
    530                 535                 540                 


Gln Thr Trp Val Thr Leu Arg Gln Arg His Thr Glu Gly Ala Ile Leu 
545                 550                 555                 560 


Tyr Glu Lys Lys Leu Lys Pro Phe Leu Lys Ser Leu Asn Glu Gly Lys 
                565                 570                 575     


Glu Gly Pro Pro Leu Ser Asn Thr Thr Phe Pro His Val Leu Pro Leu 
            580                 585                 590         


Ile Thr Leu Leu Glu Cys Asp Ser Ala Pro Pro Glu Gly Pro Glu Pro 
        595                 600                 605             


Trp Gly Ser Thr Glu His Gly Val Glu Val Val Leu Ala His Leu Glu 
    610                 615                 620                 


Ala Ala Arg Thr Val Ala His His Gly Gly Leu Tyr His Thr Asn Ala 
625                 630                 635                 640 


Glu Val Lys Leu Gln Gly Phe Gln Ala Arg Pro Glu Leu Leu Glu Val 
                645                 650                 655     


Phe Ser Thr Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Gln Gly Ala 
            660                 665                 670         


Ser Ser Ser Gln Ala Arg Arg Tyr Glu Lys Phe Asp Lys Val Leu Thr 
        675                 680                 685             


Ala Leu Ser His Lys Leu Glu Pro Ala Val Arg Ser Ser Glu Leu 
    690                 695                 700             


<210>  925
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  925

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  926
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  926

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 
145                 150                 155                 160 


Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
            180                 185                 190         


Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 
        195                 200                 205             


His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 
    210                 215                 220                 


Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 
225                 230                 235                 240 


Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 
                245                 250                 255     


Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 
            260                 265                 270         


Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 
        275                 280                 285             


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 
    290                 295                 300                 


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 
305                 310                 315                 320 


Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 
                325                 330                 335     


Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 
            340                 345                 350         


Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 
        355                 360                 365             


Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 
    370                 375                 380                 


Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 
385                 390                 395             


<210>  927
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  927

Met Gln Gly Lys Lys Pro Gly Gly Ser Ser Gly Gly Gly Arg Ser Gly 
1               5                   10                  15      


Glu Leu Gln Gly Asp Glu Ala Gln Arg Asn Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Val Ser Cys Phe Ser Asn Ile Lys Ile Phe Leu Val Ser Glu Cys Ala 
        35                  40                  45              


Leu Met Leu Ala Gln Gly Thr Val Gly Ala Tyr Leu Val Ser Val Leu 
    50                  55                  60                  


Thr Thr Leu Glu Arg Arg Phe Asn Leu Gln Ser Ala Asp Val Gly Val 
65                  70                  75                  80  


Ile Ala Ser Ser Phe Glu Ile Gly Asn Leu Ala Leu Ile Leu Phe Val 
                85                  90                  95      


Ser Tyr Phe Gly Ala Arg Gly His Arg Pro Arg Leu Ile Gly Cys Gly 
            100                 105                 110         


Gly Ile Val Met Ala Leu Gly Ala Leu Leu Ser Ala Leu Pro Glu Phe 
        115                 120                 125             


Leu Thr His Gln Tyr Lys Tyr Glu Ala Gly Glu Ile Arg Trp Gly Ala 
    130                 135                 140                 


Glu Gly Arg Asp Val Cys Ala Ala Asn Gly Ser Gly Gly Asp Glu Gly 
145                 150                 155                 160 


Pro Asp Pro Asp Leu Ile Cys Arg Asn Arg Thr Ala Thr Asn Met Met 
                165                 170                 175     


Tyr Leu Leu Leu Ile Gly Ala Gln Val Leu Leu Gly Ile Gly Ala Thr 
            180                 185                 190         


Pro Val Gln Pro Leu Gly Val Ser Tyr Ile Asp Asp His Val Arg Arg 
        195                 200                 205             


Lys Asp Ser Ser Leu Tyr Ile Gly Ile Leu Phe Thr Met Leu Val Phe 
    210                 215                 220                 


Gly Pro Ala Cys Gly Phe Ile Leu Gly Ser Phe Cys Thr Lys Ile Tyr 
225                 230                 235                 240 


Val Asp Ala Val Phe Ile Asp Thr Ser Asn Leu Asp Ile Thr Pro Asp 
                245                 250                 255     


Asp Pro Arg Trp Ile Gly Ala Trp Trp Gly Gly Phe Leu Leu Cys Gly 
            260                 265                 270         


Ala Leu Leu Phe Phe Ser Ser Leu Leu Met Phe Gly Phe Pro Gln Ser 
        275                 280                 285             


Leu Pro Pro His Ser Glu Pro Ala Met Glu Ser Glu Gln Ala Met Leu 
    290                 295                 300                 


Ser Glu Arg Glu Tyr Glu Arg Pro Lys Pro Ser Asn Gly Val Leu Arg 
305                 310                 315                 320 


His Pro Leu Glu Pro Asp Ser Ser Ala Ser Cys Phe Gln Gln Leu Arg 
                325                 330                 335     


Val Ile Pro Lys Val Thr Lys His Leu Leu Ser Asn Pro Val Phe Thr 
            340                 345                 350         


Cys Ile Ile Leu Ala Ala Cys Met Glu Ile Ala Val Val Ala Gly Phe 
        355                 360                 365             


Ala Ala Phe Leu Gly Lys Tyr Leu Glu Gln Gln Phe Asn Leu Thr Thr 
    370                 375                 380                 


Ser Ser Ala Asn Gln Leu Leu Gly Met Thr Ala Ile Pro Cys Ala Cys 
385                 390                 395                 400 


Leu Gly Ile Phe Leu Gly Gly Leu Leu Val Lys Lys Leu Ser Leu Ser 
                405                 410                 415     


Ala Leu Gly Ala Ile Arg Met Ala Met Leu Val Asn Leu Val Ser Thr 
            420                 425                 430         


Ala Cys Tyr Val Ser Phe Leu Phe Leu Gly Cys Asp Thr Gly Pro Val 
        435                 440                 445             


Ala Gly Val Thr Val Pro Tyr Gly Asn Ser Thr Ala Pro Gly Ser Ala 
    450                 455                 460                 


Leu Asp Pro Tyr Ser Pro Cys Asn Asn Asn Cys Glu Cys Gln Thr Asp 
465                 470                 475                 480 


Ser Phe Thr Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr Leu Ser Ala 
                485                 490                 495     


Cys Phe Ala Gly Cys Asn Ser Thr Asn Leu Thr Gly Cys Ala Cys Leu 
            500                 505                 510         


Thr Thr Val Pro Ala Glu Asn Ala Thr Val Val Pro Gly Lys Cys Pro 
        515                 520                 525             


Ser Pro Gly Cys Gln Glu Ala Phe Leu Thr Phe Leu Cys Val Met Cys 
    530                 535                 540                 


Ile Cys Ser Leu Ile Gly Ala Met Ala Gln Thr Pro Ser Val Ile Ile 
545                 550                 555                 560 


Leu Ile Arg Thr Val Ser Pro Glu Leu Lys Ser Tyr Ala Leu Gly Val 
                565                 570                 575     


Leu Phe Leu Leu Leu Arg Leu Leu Gly Phe Ile Pro Pro Pro Leu Ile 
            580                 585                 590         


Phe Gly Ala Gly Ile Asp Ser Thr Cys Leu Phe Trp Ser Thr Phe Cys 
        595                 600                 605             


Gly Glu Gln Gly Ala Cys Val Leu Tyr Asp Asn Val Val Tyr Arg Tyr 
    610                 615                 620                 


Leu Tyr Val Ser Ile Ala Ile Ala Leu Lys Ser Phe Ala Phe Ile Leu 
625                 630                 635                 640 


Tyr Thr Thr Thr Trp Gln Cys Leu Arg Lys Asn Tyr Lys Arg Tyr Ile 
                645                 650                 655     


Lys Asn His Glu Gly Gly Leu Ser Thr Ser Glu Phe Phe Ala Ser Thr 
            660                 665                 670         


Leu Thr Leu Asp Asn Leu Gly Arg Asp Pro Val Pro Ala Asn Gln Thr 
        675                 680                 685             


His Arg Thr Lys Phe Ile Tyr Asn Leu Glu Asp His Glu Trp Cys Glu 
    690                 695                 700                 


Asn Met Glu Ser Val Leu 
705                 710 


<210>  928
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  928

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
1               5                   10                  15      


Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
            20                  25                  30          


Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
        35                  40                  45              


Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
    50                  55                  60                  


Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
65                  70                  75                  80  


Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                85                  90                  95      


Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
            100                 105                 110         


Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
        115                 120                 125             


Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
    130                 135                 140                 


Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp 
145                 150                 155                 160 


Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly 
                165                 170                 175     


His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
            180                 185                 190         


Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
        195                 200                 205             


Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
    210                 215                 220                 


Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
225                 230                 235                 240 


Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln 
                245                 250                 255     


Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
            260                 265                 270         


Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
        275                 280                 285             


Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
    290                 295                 300                 


His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
305                 310                 315                 320 


Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                325                 330                 335     


Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
            340                 345                 350         


Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
        355                 360                 365             


Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
    370                 375                 380                 


Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
385                 390                 395                 400 


Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                405                 410                 415     


Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
            420                 425                 430         


Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
        435                 440                 445             


Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
    450                 455                 460                 


Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
465                 470                 475                 480 


Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                485                 490                 495     


Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
            500                 505                 510         


Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
        515                 520                 525             


Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
    530                 535                 540                 


Ile Ala Asp Pro Gln Pro Leu Asp 
545                 550         


<210>  929
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  929

Met Ser Ile Met Asp His Ser Pro Thr Thr Gly Val Val Thr Val Ile 
1               5                   10                  15      


Val Ile Leu Ile Ala Ile Ala Ala Leu Gly Ala Leu Ile Leu Gly Cys 
            20                  25                  30          


Trp Cys Tyr Leu Arg Leu Gln Arg Ile Ser Gln Ser Glu Asp Glu Glu 
        35                  40                  45              


Ser Ile Val Gly Asp Gly Glu Thr Lys Glu Pro Phe Leu Leu Val Gln 
    50                  55                  60                  


Tyr Ser Ala Lys Gly Pro Cys Val Glu Arg Lys Ala Lys Leu Met Thr 
65                  70                  75                  80  


Pro Asn Gly Pro Glu Val His Gly 
                85              


<210>  930
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  930

Met Ala Gly Phe Lys Arg Gly Tyr Asp Gly Lys Ile Ala Gly Leu Tyr 
1               5                   10                  15      


Asp Leu Asp Lys Thr Leu Gly Arg Gly His Phe Ala Val Val Lys Leu 
            20                  25                  30          


Ala Arg His Val Phe Thr Gly Glu Lys Val Ala Val Lys Val Ile Asp 
        35                  40                  45              


Lys Thr Lys Leu Asp Thr Leu Ala Thr Gly His Leu Phe Gln Glu Val 
    50                  55                  60                  


Arg Cys Met Lys Leu Val Gln His Pro Asn Ile Val Arg Leu Tyr Glu 
65                  70                  75                  80  


Val Ile Asp Thr Gln Thr Lys Leu Tyr Leu Ile Leu Glu Leu Gly Asp 
                85                  90                  95      


Gly Gly Asp Met Phe Asp Tyr Ile Met Lys His Glu Glu Gly Leu Asn 
            100                 105                 110         


Glu Asp Leu Ala Lys Lys Tyr Phe Ala Gln Ile Val His Ala Ile Ser 
        115                 120                 125             


Tyr Cys His Lys Leu His Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Val Phe Phe Glu Lys Gln Gly Leu Val Lys Leu Thr Asp Phe Gly 
145                 150                 155                 160 


Phe Ser Asn Lys Phe Gln Pro Gly Lys Lys Leu Thr Thr Ser Cys Gly 
                165                 170                 175     


Ser Leu Ala Tyr Ser Ala Pro Glu Ile Leu Leu Gly Asp Glu Tyr Asp 
            180                 185                 190         


Ala Pro Ala Val Asp Ile Trp Ser Leu Gly Val Ile Leu Phe Met Leu 
        195                 200                 205             


Val Cys Gly Gln Pro Pro Phe Gln Glu Ala Asn Asp Ser Glu Thr Leu 
    210                 215                 220                 


Thr Met Ile Met Asp Cys Lys Tyr Thr Val Pro Ser His Val Ser Lys 
225                 230                 235                 240 


Glu Cys Lys Asp Leu Ile Thr Arg Met Leu Gln Arg Asp Pro Lys Arg 
                245                 250                 255     


Arg Ala Ser Leu Glu Glu Ile Glu Asn His Pro Trp Leu Gln Gly Val 
            260                 265                 270         


Asp Pro Ser Pro Ala Thr Lys Tyr Asn Ile Pro Leu Val Ser Tyr Lys 
        275                 280                 285             


Asn Leu Ser Glu Glu Glu His Asn Ser Ile Ile Gln Arg Met Val Leu 
    290                 295                 300                 


Gly Asp Ile Ala Asp Arg Asp Ala Ile Val Glu Ala Leu Glu Thr Asn 
305                 310                 315                 320 


Arg Tyr Asn His Ile Thr Ala Thr Tyr Phe Leu Leu Ala Glu Arg Ile 
                325                 330                 335     


Leu Arg Glu Lys Gln Glu Lys Glu Ile Gln Thr Arg Ser Ala Ser Pro 
            340                 345                 350         


Ser Asn Ile Lys Ala Gln Phe Arg Gln Ser Trp Pro Thr Lys Ile Asp 
        355                 360                 365             


Val Pro Gln Asp Leu Glu Asp Asp Leu Thr Ala Thr Pro Leu Ser His 
    370                 375                 380                 


Ala Thr Val Pro Gln Ser Pro Ala Arg Ala Ala Asp Ser Val Leu Asn 
385                 390                 395                 400 


Gly His Arg Ser Lys Gly Leu Cys Asp Ser Ala Lys Lys Asp Asp Leu 
                405                 410                 415     


Pro Glu Leu Ala Gly Pro Ala Leu Ser Thr Val Pro Pro Ala Ser Leu 
            420                 425                 430         


Lys Pro Thr Ala Ser Gly Arg Lys Cys Leu Phe Arg Val Glu Glu Asp 
        435                 440                 445             


Glu Glu Glu Asp Glu Glu Asp Lys Lys Pro Met Ser Leu Ser Thr Gln 
    450                 455                 460                 


Val Val Leu Arg Arg Lys Pro Ser Val Thr Asn Arg Leu Thr Ser Arg 
465                 470                 475                 480 


Lys Ser Ala Pro Val Leu Asn Gln Ile Phe Glu Glu Gly Glu Ser Asp 
                485                 490                 495     


Asp Glu Phe Asp Met Asp Glu Asn Leu Pro Pro Lys Leu Ser Arg Leu 
            500                 505                 510         


Lys Met Asn Ile Ala Ser Pro Gly Thr Val His Lys Arg Tyr His Arg 
        515                 520                 525             


Arg Lys Ser Gln Gly Arg Gly Ser Ser Cys Ser Ser Ser Glu Thr Ser 
    530                 535                 540                 


Asp Asp Asp Ser Glu Ser Arg Arg Arg Leu Asp Lys Asp Ser Gly Phe 
545                 550                 555                 560 


Thr Tyr Ser Trp His Arg Arg Asp Ser Ser Glu Gly Pro Pro Gly Ser 
                565                 570                 575     


Glu Gly Asp Gly Gly Gly Gln Ser Lys Pro Ser Asn Ala Ser Gly Gly 
            580                 585                 590         


Val Asp Lys Ala Ser Pro Ser Glu Asn Asn Ala Gly Gly Gly Ser Pro 
        595                 600                 605             


Ser Ser Gly Ser Gly Gly Asn Pro Thr Asn Thr Ser Gly Thr Thr Arg 
    610                 615                 620                 


Arg Cys Ala Gly Pro Ser Asn Ser Met Gln Leu Ala Ser Arg Ser Ala 
625                 630                 635                 640 


Gly Glu Leu Val Glu Ser Leu Lys Leu Met Ser Leu Cys Leu Gly Ser 
                645                 650                 655     


Gln Leu His Gly Ser Thr Lys Tyr Ile Ile Asp Pro Gln Asn Gly Leu 
            660                 665                 670         


Ser Phe Ser Ser Val Lys Val Gln Glu Lys Ser Thr Trp Lys Met Cys 
        675                 680                 685             


Ile Ser Ser Thr Gly Asn Ala Gly Gln Val Pro Ala Val Gly Gly Ile 
    690                 695                 700                 


Lys Phe Phe Ser Asp His Met Ala Asp Thr Thr Thr Glu Leu Glu Arg 
705                 710                 715                 720 


Ile Lys Ser Lys Asn Leu Lys Asn Asn Val Leu Gln Leu Pro Leu Cys 
                725                 730                 735     


Glu Lys Thr Ile Ser Val Asn Ile Gln Arg Asn Pro Lys Glu Gly Leu 
            740                 745                 750         


Leu Cys Ala Ser Ser Pro Ala Ser Cys Cys His Val Ile 
        755                 760                 765 


<210>  931
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  931

Met Ala Asp Glu Asp Gly Glu Gly Ile His Pro Ser Ala Pro His Arg 
1               5                   10                  15      


Asn Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Leu His Cys Ala Gly 
            20                  25                  30          


Asn Gly Gly Gly Gly Gly Gly Gly Pro Arg Val Val Arg Ile Val Lys 
        35                  40                  45              


Ser Glu Ser Gly Tyr Gly Phe Asn Val Arg Gly Gln Val Ser Glu Gly 
    50                  55                  60                  


Gly Gln Leu Arg Ser Ile Asn Gly Glu Leu Tyr Ala Pro Leu Gln His 
65                  70                  75                  80  


Val Ser Ala Val Leu Pro Gly Gly Ala Ala Asp Arg Ala Gly Val Arg 
                85                  90                  95      


Lys Gly Asp Arg Ile Leu Glu Val Asn His Val Asn Val Glu Gly Ala 
            100                 105                 110         


Thr His Lys Gln Val Val Asp Leu Ile Arg Ala Gly Glu Lys Glu Leu 
        115                 120                 125             


Ile Leu Thr Val Leu Ser Val Pro Pro His Glu Ala Asp Asn Leu Asp 
    130                 135                 140                 


Pro Ser Asp Asp Ser Leu Gly Gln Ser Phe Tyr Asp Tyr Thr Glu Lys 
145                 150                 155                 160 


Gln Ala Val Pro Ile Ser Val Pro Arg Tyr Lys His Val Glu Gln Asn 
                165                 170                 175     


Gly Glu Lys Phe Val Val Tyr Asn Val Tyr Met Ala Gly Arg Gln Leu 
            180                 185                 190         


Cys Ser Lys Arg Tyr Arg Glu Phe Ala Ile Leu His Gln Asn Leu Lys 
        195                 200                 205             


Arg Glu Phe Ala Asn Phe Thr Phe Pro Arg Leu Pro Gly Lys Trp Pro 
    210                 215                 220                 


Phe Ser Leu Ser Glu Gln Gln Leu Asp Ala Arg Arg Arg Gly Leu Glu 
225                 230                 235                 240 


Glu Tyr Leu Glu Lys Val Cys Ser Ile Arg Val Ile Gly Glu Ser Asp 
                245                 250                 255     


Ile Met Gln Glu Phe Leu Ser Glu Ser Asp Glu Asn Tyr Asn Gly Val 
            260                 265                 270         


Ser Asp Val Glu Leu Arg Val Ala Leu Pro Asp Gly Thr Thr Val Thr 
        275                 280                 285             


Val Arg Val Lys Lys Asn Ser Thr Thr Asp Gln Val Tyr Gln Ala Ile 
    290                 295                 300                 


Ala Ala Lys Val Gly Met Asp Ser Thr Thr Val Asn Tyr Phe Ala Leu 
305                 310                 315                 320 


Phe Glu Val Ile Ser His Ser Phe Val Arg Lys Leu Ala Pro Asn Glu 
                325                 330                 335     


Phe Pro His Lys Leu Tyr Ile Gln Asn Tyr Thr Ser Ala Val Pro Gly 
            340                 345                 350         


Thr Cys Leu Thr Ile Arg Lys Trp Leu Phe Thr Thr Glu Glu Glu Ile 
        355                 360                 365             


Leu Leu Asn Asp Asn Asp Leu Ala Val Thr Tyr Phe Phe His Gln Ala 
    370                 375                 380                 


Val Asp Asp Val Lys Lys Gly Tyr Ile Lys Ala Glu Glu Lys Ser Tyr 
385                 390                 395                 400 


Gln Leu Gln Lys Leu Tyr Glu Gln Arg Lys Met Val Met Tyr Leu Asn 
                405                 410                 415     


Met Leu Arg Thr Cys Glu Gly Tyr Asn Glu Ile Ile Phe Pro His Cys 
            420                 425                 430         


Ala Cys Asp Ser Arg Arg Lys Gly His Val Ile Thr Ala Ile Ser Ile 
        435                 440                 445             


Thr His Phe Lys Leu His Ala Cys Thr Glu Glu Gly Gln Leu Glu Asn 
    450                 455                 460                 


Gln Val Ile Ala Phe Glu Trp Asp Glu Met Gln Arg Trp Asp Thr Asp 
465                 470                 475                 480 


Glu Glu Gly Met Ala Phe Cys Phe Glu Tyr Ala Arg Gly Glu Lys Lys 
                485                 490                 495     


Pro Arg Trp Val Lys Ile Phe Thr Pro Tyr Phe Asn Tyr Met His Glu 
            500                 505                 510         


Cys Phe Glu Arg Val Phe Cys Glu Leu Lys Trp Arg Lys Glu Glu Tyr 
        515                 520                 525             


<210>  932
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  932

Met Val Gly Glu Glu Lys Met Ser Leu Arg Asn Arg Leu Ser Lys Ser 
1               5                   10                  15      


Arg Glu Asn Pro Glu Glu Asp Glu Asp Gln Arg Asn Pro Ala Lys Glu 
            20                  25                  30          


Ser Leu Glu Thr Pro Ser Asn Gly Arg Ile Asp Ile Lys Gln Leu Ile 
        35                  40                  45              


Ala Lys Lys Ile Lys Leu Thr Ala Glu Ala Glu Glu Leu Lys Pro Phe 
    50                  55                  60                  


Phe Met Lys Glu Val Gly Ser His Phe Asp Asp Phe Val Thr Asn Leu 
65                  70                  75                  80  


Ile Glu Lys Ser Ala Ser Leu Asp Asn Gly Gly Cys Ala Leu Thr Thr 
                85                  90                  95      


Phe Ser Val Leu Glu Gly Glu Lys Asn Asn His Arg Ala Lys Asp Leu 
            100                 105                 110         


Arg Ala Pro Pro Glu Gln Gly Lys Ile Phe Ile Ala Arg Arg Ser Leu 
        115                 120                 125             


Leu Asp Glu Leu Leu Glu Val Asp His Ile Arg Thr Ile Tyr His Met 
    130                 135                 140                 


Phe Ile Ala Leu Leu Ile Leu Phe Ile Leu Ser Thr Leu Val Val Asp 
145                 150                 155                 160 


Tyr Ile Asp Glu Gly Arg Leu Val Leu Glu Phe Ser Leu Leu Ser Tyr 
                165                 170                 175     


Ala Phe Gly Lys Phe Pro Thr Val Val Trp Thr Trp Trp Ile Met Phe 
            180                 185                 190         


Leu Ser Thr Phe Ser Val Pro Tyr Phe Leu Phe Gln His Trp Ala Thr 
        195                 200                 205             


Gly Tyr Ser Lys Ser Ser His Pro Leu Ile Arg Ser Leu Phe His Gly 
    210                 215                 220                 


Phe Leu Phe Met Ile Phe Gln Ile Gly Val Leu Gly Phe Gly Pro Thr 
225                 230                 235                 240 


Tyr Val Val Leu Ala Tyr Thr Leu Pro Pro Ala Ser Arg Phe Ile Ile 
                245                 250                 255     


Ile Phe Glu Gln Ile Arg Phe Val Met Lys Ala His Ser Phe Val Arg 
            260                 265                 270         


Glu Asn Val Pro Arg Val Leu Asn Ser Ala Lys Glu Lys Ser Ser Thr 
        275                 280                 285             


Val Pro Ile Pro Thr Val Asn Gln Tyr Leu Tyr Phe Leu Phe Ala Pro 
    290                 295                 300                 


Thr Leu Ile Tyr Arg Asp Ser Tyr Pro Arg Asn Pro Thr Val Arg Trp 
305                 310                 315                 320 


Gly Tyr Val Ala Met Lys Phe Ala Gln Val Phe Gly Cys Phe Phe Tyr 
                325                 330                 335     


Val Tyr Tyr Ile Phe Glu Arg Leu Cys Ala Pro Leu Phe Arg Asn Ile 
            340                 345                 350         


Lys Gln Glu Pro Phe Ser Ala Arg Val Leu Val Leu Cys Val Phe Asn 
        355                 360                 365             


Ser Ile Leu Pro Gly Val Leu Ile Leu Phe Leu Thr Phe Phe Ala Phe 
    370                 375                 380                 


Leu His Cys Trp Leu Asn Ala Phe Ala Glu Met Leu Arg Phe Gly Asp 
385                 390                 395                 400 


Arg Met Phe Tyr Lys Asp Trp Trp Asn Ser Thr Ser Tyr Ser Asn Tyr 
                405                 410                 415     


Tyr Arg Thr Trp Asn Val Val Val His Asp Trp Leu Tyr Tyr Tyr Ala 
            420                 425                 430         


Tyr Lys Asp Phe Leu Trp Phe Phe Ser Lys Arg Phe Lys Ser Ala Ala 
        435                 440                 445             


Met Leu Ala Val Phe Ala Val Ser Ala Val Val His Glu Tyr Ala Leu 
    450                 455                 460                 


Ala Val Cys Leu Ser Phe Phe Tyr Pro Val Leu Phe Val Leu Phe Met 
465                 470                 475                 480 


Phe Phe Gly Met Ala Phe Asn Phe Ile Val Asn Asp Ser Arg Lys Lys 
                485                 490                 495     


Pro Ile Trp Asn Val Leu Met Trp Thr Ser Leu Phe Leu Gly Asn Gly 
            500                 505                 510         


Val Leu Leu Cys Phe Tyr Ser Gln Glu Trp Tyr Ala Arg Gln His Cys 
        515                 520                 525             


Pro Leu Lys Asn Pro Thr Phe Leu Asp Tyr Val Arg Pro Arg Ser Trp 
    530                 535                 540                 


Thr Cys Arg Tyr Val Phe 
545                 550 


<210>  933
<211>  2214
<212>  PRT
<213>  Homo sapiens

<400>  933

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Val Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  934
<211>  1332
<212>  PRT
<213>  Homo sapiens

<400>  934

Met Gln Gln Ala Pro Gln Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ser 
1               5                   10                  15      


Pro Lys Trp Arg Gly Leu Leu Val Ser Ala Leu Arg Lys Val Gln Glu 
            20                  25                  30          


Gln Val His Pro Thr Leu Ser Ala Asn Glu Glu Ser Leu Tyr Tyr Ile 
        35                  40                  45              


Glu Glu Leu Ile Phe Gln Leu Leu Asn Lys Leu Cys Met Ala Gln Pro 
    50                  55                  60                  


Arg Thr Val Gln Asp Val Glu Glu Arg Val Gln Lys Thr Phe Pro His 
65                  70                  75                  80  


Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                85                  90                  95      


Arg Lys Arg Arg Asn Pro Leu Leu Leu Pro Val Asp Lys Ile His Pro 
            100                 105                 110         


Ser Leu Lys Glu Val Leu Gly Tyr Lys Val Asp Tyr His Val Ser Leu 
        115                 120                 125             


Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
    130                 135                 140                 


Ala Gly Asn Tyr Val Phe Asn Ile Arg His Tyr Glu Ile Ser Gln Gln 
145                 150                 155                 160 


Asp Ile Lys Val Ser Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                165                 170                 175     


Asp Gln Asp Asp Ile Gly Leu Val Ser Leu Cys Glu Asp Glu Pro Ser 
            180                 185                 190         


Ser Ser Gly Glu Leu Asn Tyr Tyr Asp Leu Val Arg Thr Glu Ile Ala 
        195                 200                 205             


Glu Glu Arg Gln Tyr Leu Arg Glu Leu Asn Met Ile Ile Lys Val Phe 
    210                 215                 220                 


Arg Glu Ala Phe Leu Ser Asp Arg Lys Leu Phe Lys Pro Ser Asp Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Ser Asn Ile Ser Asp Ile His Glu Leu Thr Val Lys 
                245                 250                 255     


Leu Leu Gly Leu Ile Glu Asp Thr Val Glu Met Thr Asp Glu Ser Ser 
            260                 265                 270         


Pro His Pro Leu Ala Gly Ser Cys Phe Glu Asp Leu Ala Glu Glu Gln 
        275                 280                 285             


Ala Phe Asp Pro Tyr Glu Thr Leu Ser Gln Asp Ile Leu Ser Pro Glu 
    290                 295                 300                 


Phe His Glu His Phe Asn Lys Leu Met Ala Arg Pro Ala Val Ala Leu 
305                 310                 315                 320 


His Phe Gln Ser Ile Ala Asp Gly Phe Lys Glu Ala Val Arg Tyr Val 
                325                 330                 335     


Leu Pro Arg Leu Met Leu Val Pro Val Tyr His Cys Trp His Tyr Phe 
            340                 345                 350         


Glu Leu Leu Lys Gln Leu Lys Ala Cys Ser Glu Glu Gln Glu Asp Arg 
        355                 360                 365             


Glu Cys Leu Asn Gln Ala Ile Thr Ala Leu Met Asn Leu Gln Gly Ser 
    370                 375                 380                 


Met Asp Arg Ile Tyr Lys Gln Tyr Ser Pro Arg Arg Arg Pro Gly Asp 
385                 390                 395                 400 


Pro Val Cys Pro Phe Tyr Ser His Gln Leu Arg Ser Lys His Leu Ala 
                405                 410                 415     


Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp Glu Gly 
            420                 425                 430         


Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly Pro Leu 
        435                 440                 445             


Thr Arg Ile Gly Ala Lys His Glu Arg His Ile Phe Leu Phe Asp Gly 
    450                 455                 460                 


Leu Met Ile Ser Cys Lys Pro Asn His Gly Gln Thr Arg Leu Pro Gly 
465                 470                 475                 480 


Tyr Ser Ser Ala Glu Tyr Arg Leu Lys Glu Lys Phe Val Met Arg Lys 
                485                 490                 495     


Ile Gln Ile Cys Asp Lys Glu Asp Thr Cys Glu His Lys His Ala Phe 
            500                 505                 510         


Glu Leu Val Ser Lys Asp Glu Asn Ser Ile Ile Phe Ala Ala Lys Ser 
        515                 520                 525             


Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu His Tyr 
    530                 535                 540                 


Arg Ser Thr Leu Asp Arg Met Leu Asp Ser Val Leu Leu Lys Glu Glu 
545                 550                 555                 560 


Asn Glu Gln Pro Leu Arg Leu Pro Ser Pro Glu Val Tyr Arg Phe Val 
                565                 570                 575     


Val Lys Asp Ser Glu Glu Asn Ile Val Phe Glu Asp Asn Leu Gln Ser 
            580                 585                 590         


Arg Ser Gly Ile Pro Ile Ile Lys Gly Gly Thr Val Val Lys Leu Ile 
        595                 600                 605             


Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr 
    610                 615                 620                 


Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser 
625                 630                 635                 640 


Leu Leu Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Asp Ala 
                645                 650                 655     


Asp Lys Leu Ala Ile Glu Lys Gly Glu Gln Pro Ile Ser Ala Asp Leu 
            660                 665                 670         


Lys Arg Phe Arg Lys Glu Tyr Val Gln Pro Val Gln Leu Arg Ile Leu 
        675                 680                 685             


Asn Val Phe Arg His Trp Val Glu His His Phe Tyr Asp Phe Glu Arg 
    690                 695                 700                 


Asp Leu Glu Leu Leu Glu Arg Leu Glu Ser Phe Ile Ser Ser Val Arg 
705                 710                 715                 720 


Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Ala Lys Ile Ile Arg 
                725                 730                 735     


Arg Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe 
            740                 745                 750         


Glu Ser Pro Pro Pro Pro Ile Glu Trp His Ile Ser Lys Pro Gly Gln 
        755                 760                 765             


Phe Glu Thr Phe Asp Leu Met Thr Leu His Pro Ile Glu Ile Ala Arg 
    770                 775                 780                 


Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Lys Val Gln Pro Ser 
785                 790                 795                 800 


Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser 
                805                 810                 815     


Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp 
            820                 825                 830         


Phe Glu Lys Cys Ile Val Glu Ala Glu Asn Phe Glu Glu Arg Val Ala 
        835                 840                 845             


Val Leu Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Asp Leu Asn 
    850                 855                 860                 


Asn Phe Asn Gly Val Leu Glu Ile Val Ser Ala Val Asn Ser Val Ser 
865                 870                 875                 880 


Val Tyr Arg Leu Asp His Thr Phe Glu Ala Leu Gln Glu Arg Lys Arg 
                885                 890                 895     


Lys Ile Leu Asp Glu Ala Val Glu Leu Ser Gln Asp His Phe Lys Lys 
            900                 905                 910         


Tyr Leu Val Lys Leu Lys Ser Ile Asn Pro Pro Cys Val Pro Phe Phe 
        915                 920                 925             


Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Asn Asp 
    930                 935                 940                 


Phe Leu Lys Lys Lys Gly Lys Asp Leu Ile Asn Phe Ser Lys Arg Arg 
945                 950                 955                 960 


Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro 
                965                 970                 975     


Tyr Cys Leu Arg Ile Glu Pro Asp Met Arg Arg Phe Phe Glu Asn Leu 
            980                 985                 990         


Asn Pro Met Gly Ser Ala Ser Glu  Lys Glu Phe Thr Asp  Tyr Leu Phe 
        995                 1000                 1005             


Asn Lys  Ser Leu Glu Ile Glu  Pro Arg Asn Cys Lys  Gln Pro Pro 
    1010                 1015                 1020             


Arg Phe  Pro Arg Lys Ser Thr  Phe Ser Leu Lys Ser  Pro Gly Ile 
    1025                 1030                 1035             


Arg Pro  Asn Thr Gly Arg His  Gly Ser Thr Ser Gly  Thr Leu Arg 
    1040                 1045                 1050             


Gly His  Pro Thr Pro Leu Glu  Arg Glu Pro Cys Lys  Ile Ser Phe 
    1055                 1060                 1065             


Ser Arg  Ile Ala Glu Thr Glu  Leu Glu Ser Thr Val  Ser Ala Pro 
    1070                 1075                 1080             


Thr Ser  Pro Asn Thr Pro Ser  Thr Pro Pro Val Ser  Ala Ser Ser 
    1085                 1090                 1095             


Asp Leu  Ser Val Phe Leu Asp  Val Asp Leu Asn Ser  Ser Cys Gly 
    1100                 1105                 1110             


Ser Asn  Ser Ile Phe Ala Pro  Val Leu Leu Pro His  Ser Lys Ser 
    1115                 1120                 1125             


Phe Phe  Ser Ser Cys Gly Ser  Leu His Lys Leu Ser  Glu Glu Pro 
    1130                 1135                 1140             


Leu Ile  Pro Pro Pro Leu Pro  Pro Arg Lys Lys Phe  Asp His Asp 
    1145                 1150                 1155             


Ala Ser  Asn Ser Lys Gly Asn  Met Lys Ser Asp Asp  Asp Pro Pro 
    1160                 1165                 1170             


Ala Ile  Pro Pro Arg Gln Pro  Pro Pro Pro Lys Val  Lys Pro Arg 
    1175                 1180                 1185             


Val Pro  Val Pro Thr Gly Ala  Phe Asp Gly Pro Leu  His Ser Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro Pro Arg Asp  Pro Leu Pro Asp Thr  Pro Pro Pro 
    1205                 1210                 1215             


Val Pro  Leu Arg Pro Pro Glu  His Phe Ile Asn Cys  Pro Phe Asn 
    1220                 1225                 1230             


Leu Gln  Pro Pro Pro Leu Gly  His Leu His Arg Asp  Ser Asp Trp 
    1235                 1240                 1245             


Leu Arg  Asp Ile Ser Thr Cys  Pro Asn Ser Pro Ser  Thr Pro Pro 
    1250                 1255                 1260             


Ser Thr  Pro Ser Pro Arg Val  Pro Arg Arg Cys Tyr  Val Leu Ser 
    1265                 1270                 1275             


Ser Ser  Gln Asn Asn Leu Ala  His Pro Pro Ala Pro  Pro Val Pro 
    1280                 1285                 1290             


Pro Arg  Gln Asn Ser Ser Pro  His Leu Pro Lys Leu  Pro Pro Lys 
    1295                 1300                 1305             


Thr Tyr  Lys Arg Glu Leu Ser  His Pro Pro Leu Tyr  Arg Leu Pro 
    1310                 1315                 1320             


Leu Leu  Glu Asn Ala Glu Thr  Pro Gln 
    1325                 1330         


<210>  935
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  935

Met Thr Ala Pro Glu Lys Pro Val Lys Gln Glu Glu Met Ala Ala Leu 
1               5                   10                  15      


Asp Val Asp Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly His Gly Glu 
            20                  25                  30          


Tyr Leu Gln Gln Gln Gln Gln His Gly Asn Gly Ala Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Gln Asp Thr Gln Pro Ser Pro Leu Ala Leu Leu Ala Ala 
    50                  55                  60                  


Thr Cys Ser Lys Ile Gly Pro Pro Ser Pro Gly Asp Asp Glu Glu Glu 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Gly Ala Pro Ala Ala Ala Gly Ala Thr Gly Asp 
                85                  90                  95      


Leu Ala Ser Ala Gln Leu Gly Gly Ala Pro Asn Arg Trp Glu Val Leu 
            100                 105                 110         


Ser Ala Thr Pro Thr Thr Ile Lys Asp Glu Ala Gly Asn Leu Val Gln 
        115                 120                 125             


Ile Pro Ser Ala Ala Thr Ser Ser Gly Gln Tyr Val Leu Pro Leu Gln 
    130                 135                 140                 


Asn Leu Gln Asn Gln Gln Ile Phe Ser Val Ala Pro Gly Ser Asp Ser 
145                 150                 155                 160 


Ser Asn Gly Thr Val Ser Ser Val Gln Tyr Gln Val Ile Pro Gln Ile 
                165                 170                 175     


Gln Ser Ala Asp Gly Gln Gln Val Gln Ile Gly Phe Thr Gly Ser Ser 
            180                 185                 190         


Asp Asn Gly Gly Ile Asn Gln Glu Ser Ser Gln Ile Gln Ile Ile Pro 
        195                 200                 205             


Gly Ser Asn Gln Thr Leu Leu Ala Ser Gly Thr Pro Ser Ala Asn Ile 
    210                 215                 220                 


Gln Asn Leu Ile Pro Gln Thr Gly Gln Val Gln Val Gln Gly Val Ala 
225                 230                 235                 240 


Ile Gly Gly Ser Ser Phe Pro Gly Gln Thr Gln Val Val Ala Asn Val 
                245                 250                 255     


Pro Leu Gly Leu Pro Gly Asn Ile Thr Phe Val Pro Ile Asn Ser Val 
            260                 265                 270         


Asp Leu Asp Ser Leu Gly Leu Ser Gly Ser Ser Gln Thr Met Thr Ala 
        275                 280                 285             


Gly Ile Asn Ala Asp Gly His Leu Ile Asn Thr Gly Gln Ala Met Asp 
    290                 295                 300                 


Ser Ser Asp Asn Ser Glu Arg Thr Gly Glu Arg Val Ser Pro Asp Ile 
305                 310                 315                 320 


Asn Glu Thr Asn Thr Asp Thr Asp Leu Phe Val Pro Thr Ser Ser Ser 
                325                 330                 335     


Ser Gln Leu Pro Val Thr Ile Asp Ser Thr Gly Ile Leu Gln Gln Asn 
            340                 345                 350         


Thr Asn Ser Leu Thr Thr Ser Ser Gly Gln Val His Ser Ser Asp Leu 
        355                 360                 365             


Gln Gly Asn Tyr Ile Gln Ser Pro Val Ser Glu Glu Thr Gln Ala Gln 
    370                 375                 380                 


Asn Ile Gln Val Ser Thr Ala Gln Pro Val Val Gln His Leu Gln Leu 
385                 390                 395                 400 


Gln Glu Ser Gln Gln Pro Thr Ser Gln Ala Gln Ile Val Gln Gly Ile 
                405                 410                 415     


Thr Pro Gln Thr Ile His Gly Val Gln Ala Ser Gly Gln Asn Ile Ser 
            420                 425                 430         


Gln Gln Ala Leu Gln Asn Leu Gln Leu Gln Leu Asn Pro Gly Thr Phe 
        435                 440                 445             


Leu Ile Gln Ala Gln Thr Val Thr Pro Ser Gly Gln Val Thr Trp Gln 
    450                 455                 460                 


Thr Phe Gln Val Gln Gly Val Gln Asn Leu Gln Asn Leu Gln Ile Gln 
465                 470                 475                 480 


Asn Thr Ala Ala Gln Gln Ile Thr Leu Thr Pro Val Gln Thr Leu Thr 
                485                 490                 495     


Leu Gly Gln Val Ala Ala Gly Gly Ala Phe Thr Ser Thr Pro Val Ser 
            500                 505                 510         


Leu Ser Thr Gly Gln Leu Pro Asn Leu Gln Thr Val Thr Val Asn Ser 
        515                 520                 525             


Ile Asp Ser Ala Gly Ile Gln Leu His Pro Gly Glu Asn Ala Asp Ser 
    530                 535                 540                 


Pro Ala Asp Ile Arg Ile Lys Glu Glu Glu Pro Asp Pro Glu Glu Trp 
545                 550                 555                 560 


Gln Leu Ser Gly Asp Ser Thr Leu Asn Thr Asn Asp Leu Thr His Leu 
                565                 570                 575     


Arg Val Gln Val Val Asp Glu Glu Gly Asp Gln Gln His Gln Glu Gly 
            580                 585                 590         


Lys Arg Leu Arg Arg Val Ala Cys Thr Cys Pro Asn Cys Lys Glu Gly 
        595                 600                 605             


Gly Gly Arg Gly Thr Asn Leu Gly Lys Lys Lys Gln His Ile Cys His 
    610                 615                 620                 


Ile Pro Gly Cys Gly Lys Val Tyr Gly Lys Thr Ser His Leu Arg Ala 
625                 630                 635                 640 


His Leu Arg Trp His Ser Gly Glu Arg Pro Phe Val Cys Asn Trp Met 
                645                 650                 655     


Tyr Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu Leu Gln Arg His Arg 
            660                 665                 670         


Arg Thr His Thr Gly Glu Lys Lys Phe Val Cys Pro Glu Cys Ser Lys 
        675                 680                 685             


Arg Phe Met Arg Ser Asp His Leu Ala Lys His Ile Lys Thr His Gln 
    690                 695                 700                 


Asn Lys Lys Gly Ile His Ser Ser Ser Thr Val Leu Ala Ser Val Glu 
705                 710                 715                 720 


Ala Ala Arg Asp Asp Thr Leu Ile Thr Ala Gly Gly Thr Thr Leu Ile 
                725                 730                 735     


Leu Ala Asn Ile Gln Gln Gly Ser Val Ser Gly Ile Gly Thr Val Asn 
            740                 745                 750         


Thr Ser Ala Thr Ser Asn Gln Asp Ile Leu Thr Asn Thr Glu Ile Pro 
        755                 760                 765             


Leu Gln Leu Val Thr Val Ser Gly Asn Glu Thr Met Glu 
    770                 775                 780     


<210>  936
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  936

Met Tyr Gly Lys Gly Lys Ser Asn Ser Ser Ala Val Pro Ser Asp Ser 
1               5                   10                  15      


Gln Ala Arg Glu Lys Leu Ala Leu Tyr Val Tyr Glu Tyr Leu Leu His 
            20                  25                  30          


Val Gly Ala Gln Lys Ser Ala Gln Thr Phe Leu Ser Glu Ile Arg Trp 
        35                  40                  45              


Glu Lys Asn Ile Thr Leu Gly Glu Pro Pro Gly Phe Leu His Ser Trp 
    50                  55                  60                  


Trp Cys Val Phe Trp Asp Leu Tyr Cys Ala Ala Pro Glu Arg Arg Glu 
65                  70                  75                  80  


Thr Cys Glu His Ser Ser Glu Ala Lys Ala Phe His Asp Tyr Ser Ala 
                85                  90                  95      


Ala Ala Ala Pro Ser Pro Val Leu Gly Asn Ile Pro Pro Gly Asp Gly 
            100                 105                 110         


Met Pro Val Gly Pro Val Pro Pro Gly Phe Phe Gln Pro Phe Met Ser 
        115                 120                 125             


Pro Arg Tyr Pro Gly Gly Pro Arg Pro Pro Leu Arg Ile Pro Asn Gln 
    130                 135                 140                 


Ala Leu Gly Gly Val Pro Gly Ser Gln Pro Leu Leu Pro Ser Gly Met 
145                 150                 155                 160 


Asp Pro Thr Arg Gln Gln Gly His Pro Asn Met Gly Gly Pro Met Gln 
                165                 170                 175     


Arg Met Thr Pro Pro Arg Gly Met Val Pro Leu Gly Pro Gln Asn Tyr 
            180                 185                 190         


Gly Gly Ala Met Arg Pro Pro Leu Asn Ala Leu Gly Gly Pro Gly Met 
        195                 200                 205             


Pro Gly Met Asn Met Gly Pro Gly Gly Gly Arg Pro Trp Pro Asn Pro 
    210                 215                 220                 


Thr Asn Ala Asn Ser Ile Pro Tyr Ser Ser Ala Ser Pro Gly Asn Tyr 
225                 230                 235                 240 


Val Gly Pro Pro Gly Gly Gly Gly Pro Pro Gly Thr Pro Ile Met Pro 
                245                 250                 255     


Ser Pro Ala Asp Ser Thr Asn Ser Gly Asp Asn Met Tyr Thr Leu Met 
            260                 265                 270         


Asn Ala Val Pro Pro Gly Pro Asn Arg Pro Asn Phe Pro Met Gly Pro 
        275                 280                 285             


Gly Ser Asp Gly Pro Met Gly Gly Leu Gly Gly Met Glu Ser His His 
    290                 295                 300                 


Met Asn Gly Ser Leu Gly Ser Gly Asp Met Asp Ser Ile Ser Lys Asn 
305                 310                 315                 320 


Ser Pro Asn Asn Met Ser Leu Ser Asn Gln Pro Gly Thr Pro Arg Asp 
                325                 330                 335     


Asp Gly Glu Met Gly Gly Asn Phe Leu Asn Pro Phe Gln Ser Glu Ser 
            340                 345                 350         


Tyr Ser Pro Ser Met Thr Met Ser Val 
        355                 360     


<210>  937
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  937

Met Asp Arg Pro Leu Ser Ser Ser Ala Glu Ala Glu Glu Glu Leu Glu 
1               5                   10                  15      


Trp Gln Val Ala Ser Arg Arg Arg Lys Ala Trp Ala Lys Cys Arg Ser 
            20                  25                  30          


Ser Trp Gln Ala Ser Glu Thr Glu Asp Leu Ser Thr Glu Ala Thr Thr 
        35                  40                  45              


Gln Asp Glu Glu Glu Asp Glu Glu Glu Asp Leu Pro Gly Ala Gln Leu 
    50                  55                  60                  


Pro Ala Ala Gly Gly Arg Gly Asn Val Pro Asn Glu Lys Ile Ala Ile 
65                  70                  75                  80  


Trp Leu Lys Asp Cys Arg Thr Pro Leu Gly Ala Ser Leu Asp Glu Gln 
                85                  90                  95      


Ser Ser Ser Thr Leu Lys Gly Val Leu Val Arg Asn Gly Gly Ser Phe 
            100                 105                 110         


Glu Asp Asp Leu Ser Leu Gly Ala Glu Ala Asn His Leu His Glu Ser 
        115                 120                 125             


Asp Ala Gln Ile Glu Asn Cys Asn Asn Ile Leu Ala Lys Glu Arg Arg 
    130                 135                 140                 


Leu Gln Phe His Gln Lys Gly Arg Ser Met Asn Ser Thr Gly Ser Gly 
145                 150                 155                 160 


Lys Ser Ser Gly Thr Val Ser Ser Val Ser Glu Leu Leu Glu Leu Tyr 
                165                 170                 175     


Glu Glu Asp Pro Glu Glu Ile Leu Tyr Asn Leu Gly Phe Gly Arg Asp 
            180                 185                 190         


Glu Pro Asp Ile Ala Ser Lys Ile Pro Ser Arg Phe Phe Asn Ser Ser 
        195                 200                 205             


Ser Phe Ala Lys Gly Ile Asp Ile Lys Val Phe Leu Ser Ala Gln Met 
    210                 215                 220                 


Gln Arg Met Glu Val Glu Asn Pro Asn Tyr Ala Leu Thr Ser Arg Phe 
225                 230                 235                 240 


Arg Gln Ile Glu Val Leu Thr Thr Val Ala Asn Ala Phe Ser Ser Leu 
                245                 250                 255     


Tyr Ser Gln Val Ser Gly Thr Pro Leu Gln Arg Ile Gly Ser Met Ser 
            260                 265                 270         


Ser Val Thr Ser Asn Lys Glu Thr Asp Pro Pro Pro Pro Leu Thr Arg 
        275                 280                 285             


Ser Asn Thr Ala Asn Arg Leu Met Lys Thr Leu Ser Lys Leu Asn Leu 
    290                 295                 300                 


Cys Val Asp Lys Thr Glu Lys Gly Glu Ser Ser Ser Pro Ser Pro Ser 
305                 310                 315                 320 


Ala Glu Lys Gly Lys Ile Leu Asn Val Ser Val Ile Glu Glu Ser Gly 
                325                 330                 335     


Asn Lys Asn Asp Gln Lys Ser Gln Lys Ile Met Lys Lys Lys Glu Ser 
            340                 345                 350         


Ser Ser Met Leu Ala Thr Val Lys Glu Glu Val Ser Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Thr Glu Asn Ala Asp Ser Asp Arg Ile Ser Asp Glu Ala Asn 
    370                 375                 380                 


Ser Asn Phe Asn Gln Gly Thr Glu Asn Glu Gln Ser Lys Glu Thr Gln 
385                 390                 395                 400 


Ser His Glu Ser Lys Leu Gly Glu Glu Ser Gly Ile Val Glu Ser Lys 
                405                 410                 415     


Leu Asp Ser Asp Phe Asn Ile Ser Ser His Ser Glu Leu Glu Asn Ser 
            420                 425                 430         


Ser Glu Leu Lys Ser Val His Ile Ser Thr Pro Glu Lys Glu Pro Cys 
        435                 440                 445             


Ala Pro Leu Thr Ile Pro Ser Ile Arg Asn Ile Met Thr Gln Gln Lys 
    450                 455                 460                 


Asp Ser Phe Glu Met Glu Glu Val Gln Ser Thr Glu Gly Glu Ala Pro 
465                 470                 475                 480 


His Val Pro Ala Thr Tyr Gln Leu Gly Leu Thr Lys Ser Lys Arg Asp 
                485                 490                 495     


His Leu Leu Arg Thr Ala Ser Gln His Ser Asp Ser Ser Gly Phe Ala 
            500                 505                 510         


Glu Asp Ser Thr Asp Cys Leu Ser Leu Asn His Leu Gln Val Gln Glu 
        515                 520                 525             


Ser Leu Gln Ala Met Gly Ser Ser Ala Asp Ser Cys Asp Ser Glu Thr 
    530                 535                 540                 


Thr Val Thr Ser Leu Gly Glu Asp Leu Ala Thr Pro Thr Ala Gln Asp 
545                 550                 555                 560 


Gln Pro Tyr Phe Asn Glu Ser Glu Glu Glu Ser Leu Val Pro Leu Gln 
                565                 570                 575     


Lys Gly Leu Glu Lys Ala Ala Ala Val Ala Asp Lys Arg Lys Ser Gly 
            580                 585                 590         


Ser Gln Asp Phe Pro Gln Cys Asn Thr Ile Glu Asn Thr Gly Thr Lys 
        595                 600                 605             


Gln Ser Thr Cys Ser Pro Gly Asp His Ile Ile Glu Ile Thr Glu Val 
    610                 615                 620                 


Glu Glu Asp Leu Phe Pro Ala Glu Thr Val Glu Leu Leu Arg Glu Ala 
625                 630                 635                 640 


Ser Ala Glu Ser Asp Val Gly Lys Ser Ser Glu Ser Glu Phe Thr Gln 
                645                 650                 655     


Tyr Thr Thr His His Ile Leu Lys Ser Leu Ala Ser Ile Glu Ala Lys 
            660                 665                 670         


Cys Ser Asp Met Ser Ser Glu Asn Thr Thr Gly Pro Pro Ser Ser Met 
        675                 680                 685             


Asp Arg Val Asn Thr Ala Leu Gln Arg Ala Gln Met Lys Val Cys Ser 
    690                 695                 700                 


Leu Ser Asn Gln Arg Met Gly Arg Ser Leu Leu Lys Ser Lys Asp Leu 
705                 710                 715                 720 


Leu Lys Gln Arg Tyr Leu Phe Ala Lys Ala Gly Tyr Pro Leu Arg Arg 
                725                 730                 735     


Ser Gln Ser Leu Pro Thr Thr Leu Leu Ser Pro Val Arg Val Val Ser 
            740                 745                 750         


Ser Val Asn Val Arg Leu Ser Pro Gly Lys Glu Thr Arg Cys Ser Pro 
        755                 760                 765             


Pro Ser Phe Thr Tyr Lys Tyr Thr Pro Glu Glu Glu Gln Glu Leu Glu 
    770                 775                 780                 


Lys Arg Val Met Glu His Asp Gly Gln Ser Leu Val Lys Ser Thr Ile 
785                 790                 795                 800 


Phe Ile Ser Pro Ser Ser Val Lys Lys Glu Glu Ala Pro Gln Ser Glu 
                805                 810                 815     


Ala Pro Arg Val Glu Glu Cys His His Gly Arg Thr Pro Thr Cys Ser 
            820                 825                 830         


Arg Leu Ala Pro Pro Pro Met Ser Gln Ser Thr Cys Ser Leu His Ser 
        835                 840                 845             


Ile His Ser Glu Trp Gln Glu Arg Pro Leu Cys Glu His Thr Arg Thr 
    850                 855                 860                 


Leu Ser Thr His Ser Val Pro Asn Ile Ser Gly Ala Thr Cys Ser Ala 
865                 870                 875                 880 


Phe Ala Ser Pro Phe Gly Cys Pro Tyr Ser His Arg His Ala Thr Tyr 
                885                 890                 895     


Pro Tyr Arg Val Cys Ser Val Asn Pro Pro Ser Ala Ile Glu Met Gln 
            900                 905                 910         


Leu Arg Arg Val Leu His Asp Ile Arg Asn Ser Leu Gln Asn Leu Ser 
        915                 920                 925             


Gln Tyr Pro Met Met Arg Gly Pro Asp Pro Ala Ala Ala Pro Tyr Ser 
    930                 935                 940                 


Thr Gln Lys Ser Ser Val Leu Pro Leu Tyr Glu Asn Thr Phe Gln Glu 
945                 950                 955                 960 


Leu Gln Val Met Arg Arg Ser Leu Asn Leu Phe Arg Thr Gln Met Met 
                965                 970                 975     


Asp Leu Glu Leu Ala Met Leu Arg Gln Gln Thr Met Val Tyr His His 
            980                 985                 990         


Met Thr Glu Glu Glu Arg Phe Glu  Val Asp Gln Leu Gln  Gly Leu Arg 
        995                 1000                 1005             


Asn Ser  Val Arg Met Glu Leu  Gln Asp Leu Glu Leu  Gln Leu Glu 
    1010                 1015                 1020             


Glu Arg  Leu Leu Gly Leu Glu  Glu Gln Leu Arg Ala  Val Arg Met 
    1025                 1030                 1035             


Pro Ser  Pro Phe Arg Ser Ser  Ala Leu Met Gly Met  Cys Gly Ser 
    1040                 1045                 1050             


Arg Ser  Ala Asp Asn Leu Ser  Cys Pro Ser Pro Leu  Asn Val Met 
    1055                 1060                 1065             


Glu Pro  Val Thr Glu Leu Met  Gln Glu Gln Ser Tyr  Leu Lys Ser 
    1070                 1075                 1080             


Glu Leu  Gly Leu Gly Leu Gly  Glu Met Gly Phe Glu  Ile Pro Pro 
    1085                 1090                 1095             


Gly Glu  Ser Ser Glu Ser Val  Phe Ser Gln Ala Thr  Ser Glu Ser 
    1100                 1105                 1110             


Ser Ser  Val Cys Ser Gly Pro  Ser His Ala Asn Arg  Arg Thr Gly 
    1115                 1120                 1125             


Val Pro  Ser Thr Ala Ser Val  Gly Lys Ser Lys Thr  Pro Leu Val 
    1130                 1135                 1140             


Ala Arg  Lys Lys Val Phe Arg  Ala Ser Val Ala Leu  Thr Pro Thr 
    1145                 1150                 1155             


Ala Pro  Ser Arg Thr Gly Ser  Val Gln Thr Pro Pro  Asp Leu Glu 
    1160                 1165                 1170             


Ser Ser  Glu Glu Val Asp Ala  Ala Glu Gly Ala Pro  Glu Val Val 
    1175                 1180                 1185             


Gly Pro  Lys Ser Glu Val Glu  Glu Gly His Gly Lys  Leu Pro Ser 
    1190                 1195                 1200             


Met Pro  Ala Ala Glu Glu Met  His Lys Asn Val Glu  Gln Asp Glu 
    1205                 1210                 1215             


Leu Gln  Gln Val Ile Arg Glu  Val Gly Met Asp Pro  Ile Ser Cys 
    1220                 1225                 1230             


Val Ile  Leu Glu Leu Ser Met  Ile Cys Thr Gly Gly  Gly Val Ile 
    1235                 1240                 1245             


Cys Ala  Leu Glu Asp Thr Cys  Cys 
    1250                 1255     


<210>  938
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  938

Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys 
1               5                   10                  15      


Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg 
            20                  25                  30          


Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys 
        35                  40                  45              


Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys 
    50                  55                  60                  


Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp 
65                  70                  75                  80  


Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro 
                85                  90                  95      


Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp 
            100                 105                 110         


Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly 
        115                 120                 125             


Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn 
    130                 135                 140                 


Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys 
145                 150                 155                 160 


Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu 
                165                 170                 175     


Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His 
            180                 185                 190         


Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala 
        195                 200                 205             


Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val 
    210                 215                 220                 


Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg 
225                 230                 235                 240 


Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys 
                245                 250                 255     


Ala Arg Glu Glu His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg 
            260                 265                 270         


Gln Ser Gly Ala Gln Tyr Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly 
        275                 280                 285             


Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Gly Met 
    290                 295                 300                 


Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro 
305                 310                 315                 320 


Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln 
                325                 330                 335     


Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro 
            340                 345                 350         


Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln 
        355                 360                 365             


Ala 
    


<210>  939
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  939

Met Val Thr Leu Arg Lys Arg Thr Leu Lys Val Leu Thr Phe Leu Val 
1               5                   10                  15      


Leu Phe Ile Phe Leu Thr Ser Phe Phe Leu Asn Tyr Ser His Thr Met 
            20                  25                  30          


Val Ala Thr Thr Trp Phe Pro Lys Gln Met Val Leu Glu Leu Ser Glu 
        35                  40                  45              


Asn Leu Lys Arg Leu Ile Lys His Arg Pro Cys Thr Cys Thr His Cys 
    50                  55                  60                  


Ile Gly Gln Arg Lys Leu Ser Ala Trp Phe Asp Glu Arg Phe Asn Gln 
65                  70                  75                  80  


Thr Met Gln Pro Leu Leu Thr Ala Gln Asn Ala Leu Leu Glu Asp Asp 
                85                  90                  95      


Thr Tyr Arg Trp Trp Leu Arg Leu Gln Arg Glu Lys Lys Pro Asn Asn 
            100                 105                 110         


Leu Asn Asp Thr Ile Lys Glu Leu Phe Arg Val Val Pro Gly Asn Val 
        115                 120                 125             


Asp Pro Met Leu Glu Lys Arg Ser Val Gly Cys Arg Arg Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Asn Leu Arg Glu Ser Ser Tyr Gly Pro Glu Ile 
145                 150                 155                 160 


Asp Ser His Asp Phe Val Leu Arg Met Asn Lys Ala Pro Thr Ala Gly 
                165                 170                 175     


Phe Glu Ala Asp Val Gly Thr Lys Thr Thr His His Leu Val Tyr Pro 
            180                 185                 190         


Glu Ser Phe Arg Glu Leu Gly Asp Asn Val Ser Met Ile Leu Val Pro 
        195                 200                 205             


Phe Lys Thr Ile Asp Leu Glu Trp Val Val Ser Ala Ile Thr Thr Gly 
    210                 215                 220                 


Thr Ile Ser His Thr Tyr Ile Pro Val Pro Ala Lys Ile Arg Val Lys 
225                 230                 235                 240 


Gln Asp Lys Ile Leu Ile Tyr His Pro Ala Phe Ile Lys Tyr Val Phe 
                245                 250                 255     


Asp Asn Trp Leu Gln Gly His Gly Arg Tyr Pro Ser Thr Gly Ile Leu 
            260                 265                 270         


Ser Val Ile Phe Ser Met His Val Cys Asp Glu Val Asp Leu Tyr Gly 
        275                 280                 285             


Phe Gly Ala Asp Ser Lys Gly Asn Trp His His Tyr Trp Glu Asn Asn 
    290                 295                 300                 


Pro Ser Ala Gly Ala Phe Arg Lys Thr Gly Val His Asp Ala Asp Phe 
305                 310                 315                 320 


Glu Ser Asn Val Thr Ala Thr Leu Ala Ser Ile Asn Lys Ile Arg Ile 
                325                 330                 335     


Phe Lys Gly Arg 
            340 


<210>  940
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  940

Met Pro Leu Phe Thr Ala Asn Pro Phe Glu Gln Asp Val Glu Lys Ala 
1               5                   10                  15      


Thr Asn Glu Tyr Asn Thr Thr Glu Asp Trp Ser Leu Ile Met Asp Ile 
            20                  25                  30          


Cys Asp Lys Val Gly Ser Thr Pro Asn Gly Ala Lys Asp Cys Leu Lys 
        35                  40                  45              


Ala Ile Met Lys Arg Val Asn His Lys Val Pro His Val Ala Leu Gln 
    50                  55                  60                  


Ala Leu Thr Leu Leu Gly Ala Cys Val Ala Asn Cys Gly Lys Ile Phe 
65                  70                  75                  80  


His Leu Glu Val Cys Ser Arg Asp Phe Ala Thr Glu Val Arg Ala Val 
                85                  90                  95      


Ile Lys Asn Lys Ala His Pro Lys Val Cys Glu Lys Leu Lys Ser Leu 
            100                 105                 110         


Met Val Glu Trp Ser Glu Glu Phe Gln Lys Asp Pro Gln Phe Ser Leu 
        115                 120                 125             


Ile Ser Ala Thr Ile Lys Ser Met Lys Glu Glu Gly Ile Thr Phe Pro 
    130                 135                 140                 


Pro Ala Gly Ser Gln Thr Val Ser Ala Ala Ala Lys Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Asn Lys Asn Lys Glu Asp Glu Asp Ile Ala Lys Ala Ile Glu Leu 
                165                 170                 175     


Ser Leu Gln Glu Gln Lys Gln Gln His Thr Glu Thr Lys Ser Leu Tyr 
            180                 185                 190         


Pro Ser Ser Glu Ile Gln Leu Asn Asn Lys Val Ala Arg Lys Val Arg 
        195                 200                 205             


Ala Leu Tyr Asp Phe Glu Ala Val Glu Asp Asn Glu Leu Thr Phe Lys 
    210                 215                 220                 


His Gly Glu Ile Ile Ile Val Leu Asp Asp Ser Asp Ala Asn Trp Trp 
225                 230                 235                 240 


Lys Gly Glu Asn His Arg Gly Ile Gly Leu Phe Pro Ser Asn Phe Val 
                245                 250                 255     


Thr Thr Asn Leu Asn Ile Glu Thr Glu Ala Ala Ala Val Asp Lys Leu 
            260                 265                 270         


Asn Val Ile Asp Asp Asp Val Glu Glu Ile Lys Lys Ser Glu Pro Glu 
        275                 280                 285             


Pro Val Tyr Ile Asp Glu Asp Lys Met Asp Arg Ala Leu Gln Val Leu 
    290                 295                 300                 


Gln Ser Ile Asp Pro Thr Asp Ser Lys Pro Asp Ser Gln Asp Leu Leu 
305                 310                 315                 320 


Asp Leu Glu Asp Ile Cys Gln Gln Met Gly Pro Met Ile Asp Glu Lys 
                325                 330                 335     


Leu Glu Glu Ile Asp Arg Lys His Ser Glu Leu Ser Glu Leu Asn Val 
            340                 345                 350         


Lys Val Leu Glu Ala Leu Glu Leu Tyr Asn Lys Leu Val Asn Glu Ala 
        355                 360                 365             


Pro Val Tyr Ser Val Tyr Ser Lys Leu His Pro Pro Ala His Tyr Pro 
    370                 375                 380                 


Pro Ala Ser Ser Gly Val Pro Met Gln Thr Tyr Pro Val Gln Ser His 
385                 390                 395                 400 


Gly Gly Asn Tyr Met Gly Gln Ser Ile His Gln Val Thr Val Ala Gln 
                405                 410                 415     


Ser Tyr Ser Leu Gly Pro Asp Gln Ile Gly Pro Leu Arg Ser Leu Pro 
            420                 425                 430         


Pro Asn Val Asn Ser Ser Val Thr Ala Gln Pro Ala Gln Thr Ser Tyr 
        435                 440                 445             


Leu Ser Thr Gly Gln Asp Thr Val Ser Asn Pro Thr Tyr Met Asn Gln 
    450                 455                 460                 


Asn Ser Asn Leu Gln Ser Ala Thr Gly Thr Thr Ala Tyr Thr Gln Gln 
465                 470                 475                 480 


Met Gly Met Ser Val Asp Met Ser Ser Tyr Gln Asn Thr Thr Ser Asn 
                485                 490                 495     


Leu Pro Gln Leu Ala Gly Phe Pro Val Thr Val Pro Ala His Pro Val 
            500                 505                 510         


Ala Gln Gln His Thr Asn Tyr His Gln Gln Pro Leu Leu 
        515                 520                 525 


<210>  941
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  941

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  942
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  942

Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg 
1               5                   10                  15      


Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser 
        115                 120                 125             


Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu 
625                 630                 635                 640 


Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala 
        675                 680                 685             


Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro 
    690                 695                 700                 


Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr 
705                 710                 715                 720 


Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn 
                725                 730                 735     


Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe 
            740                 745                 750         


Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu 
        755                 760                 765             


Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly 
    770                 775                 780                 


Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser 
785                 790                 


<210>  943
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  943

Met Ala Val Trp Ile Gln Ala Gln Gln Leu Gln Gly Glu Ala Leu His 
1               5                   10                  15      


Gln Met Gln Ala Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ser Gln Trp Ile Glu Ser Gln Ala Trp Asp Ser Val Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Glu Asn Ile Lys Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Asn 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Gly Ser Ser 
        115                 120                 125             


Pro Ala Gly Ser Leu Ala Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Gly Pro Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Asp Tyr Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ser Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Ile Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Gly Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp Asn Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Arg Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His Leu Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Gln Glu Arg Met Phe 
625                 630                 635                 640 


Trp Asn Leu Met Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Tyr Ser Lys Tyr Tyr Thr Pro Val Pro Cys 
        675                 680                 685             


Glu Ser Ala Thr Ala Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile 
    690                 695                 700                 


Lys Gln Val Val Pro Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly 
705                 710                 715                 720 


Gly Ser Ala Thr Tyr Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro 
                725                 730                 735     


Gln Ala His Tyr Asn Met Tyr Pro Gln Asn Pro Asp Ser Val Leu Asp 
            740                 745                 750         


Thr Asp Gly Asp Phe Asp Leu Glu Asp Thr Met Asp Val Ala Arg Arg 
        755                 760                 765             


Val Glu Glu Leu Leu Gly Arg Pro Met Asp Ser Gln Trp Ile Pro His 
    770                 775                 780                 


Ala Gln Ser 
785         


<210>  944
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  944

Met Ala Met Thr Ala Gly Thr Thr Thr Thr Phe Pro Met Ser Asn His 
1               5                   10                  15      


Thr Arg Glu Arg Val Thr Val Ala Lys Leu Thr Leu Glu Asn Phe Tyr 
            20                  25                  30          


Ser Asn Leu Ile Leu Gln His Glu Glu Arg Glu Thr Arg Gln Lys Lys 
        35                  40                  45              


Leu Glu Val Ala Met Glu Glu Glu Gly Leu Ala Asp Glu Glu Lys Lys 
    50                  55                  60                  


Leu Arg Arg Ser Gln His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Arg Leu Gly Leu Asp Asp Phe Glu Ser Leu Lys Val Ile 
                85                  90                  95      


Gly Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr 
            100                 105                 110         


Gly His Ile Tyr Ala Met Lys Ile Leu Arg Lys Ser Asp Met Leu Glu 
        115                 120                 125             


Lys Glu Gln Val Ala His Ile Arg Ala Glu Arg Asp Ile Leu Val Glu 
    130                 135                 140                 


Ala Asp Gly Ala Trp Val Val Lys Met Phe Tyr Ser Phe Gln Asp Lys 
145                 150                 155                 160 


Arg Asn Leu Tyr Leu Ile Met Glu Phe Leu Pro Gly Gly Asp Met Met 
                165                 170                 175     


Thr Leu Leu Met Lys Lys Asp Thr Leu Thr Glu Glu Glu Thr Gln Phe 
            180                 185                 190         


Tyr Ile Ser Glu Thr Val Leu Ala Ile Asp Ala Ile His Gln Leu Gly 
        195                 200                 205             


Phe Ile His Arg Asp Ile Lys Pro Asp Asn Leu Leu Leu Asp Ala Lys 
    210                 215                 220                 


Gly His Val Lys Leu Ser Asp Phe Gly Leu Cys Thr Gly Leu Lys Lys 
225                 230                 235                 240 


Ala His Arg Thr Glu Phe Tyr Arg Asn Leu Thr His Asn Pro Pro Ser 
                245                 250                 255     


Asp Phe Ser Phe Gln Asn Met Asn Ser Lys Arg Lys Ala Glu Thr Trp 
            260                 265                 270         


Lys Lys Asn Arg Arg Gln Leu Ala Tyr Ser Thr Val Gly Thr Pro Asp 
        275                 280                 285             


Tyr Ile Ala Pro Glu Val Phe Met Gln Thr Gly Tyr Asn Lys Leu Cys 
    290                 295                 300                 


Asp Trp Trp Ser Leu Gly Val Ile Met Tyr Glu Met Leu Ile Gly Tyr 
305                 310                 315                 320 


Pro Pro Phe Cys Ser Glu Thr Pro Gln Glu Thr Tyr Arg Lys Val Met 
                325                 330                 335     


Asn Trp Lys Glu Thr Leu Val Phe Pro Pro Glu Val Pro Ile Ser Glu 
            340                 345                 350         


Lys Ala Lys Asp Leu Ile Leu Arg Phe Cys Ile Asp Ser Glu Asn Arg 
        355                 360                 365             


Ile Gly Asn Ser Gly Val Glu Glu Ile Lys Gly His Pro Phe Phe Glu 
    370                 375                 380                 


Gly Val Asp Trp Glu His Ile Arg Glu Arg Pro Ala Ala Ile Pro Ile 
385                 390                 395                 400 


Glu Ile Lys Ser Ile Asp Asp Thr Ser Asn Phe Asp Asp Phe Pro Glu 
                405                 410                 415     


Ser Asp Ile Leu Gln Pro Val Pro Asn Thr Thr Glu Pro Asp Tyr Lys 
            420                 425                 430         


Ser Lys Asp Trp Val Phe Leu Asn Tyr Thr Tyr Lys Arg Phe Glu Gly 
        435                 440                 445             


Leu Thr Gln Arg Gly Ser Ile Pro Thr Tyr Met Lys Ala Gly Lys Leu 
    450                 455                 460                 


<210>  945
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  945

Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu 
            20                  25                  30          


Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu 
65                  70                  75                  80  


Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg 
                85                  90                  95      


Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val 
            100                 105                 110         


Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala 
        115                 120                 125             


Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala 
    130                 135                 140                 


Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met 
145                 150                 155                 160 


Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val 
                165                 170                 175     


Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly 
            180                 185                 190         


Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg 
        195                 200                 205             


Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser 
    210                 215                 220                 


Asp Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu 
225                 230                 235                 240 


Leu Val Leu Ile Leu Leu Phe Ser Leu 
                245                 


<210>  946
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  946

Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp 
1               5                   10                  15      


Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met 
            20                  25                  30          


Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys 
        35                  40                  45              


Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu 
    50                  55                  60                  


Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu 
65                  70                  75                  80  


Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys 
                85                  90                  95      


Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp 
            100                 105                 110         


Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val 
        115                 120                 125             


Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg 
    130                 135                 140                 


Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr 
145                 150                 155                 160 


Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile 
                165                 170                 175     


Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser 
            180                 185                 190         


Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
        195                 200                 205             


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
    210                 215                 220                 


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
225                 230                 235                 240 


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val 
            260                 265                 270         


Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu 
        275                 280                 285             


Asn 
    


<210>  947
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  947

Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu 
            20                  25                  30          


Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu 
65                  70                  75                  80  


Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg 
                85                  90                  95      


Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln 
            100                 105                 110         


Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly 
        115                 120                 125             


Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp 
    130                 135                 140                 


Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala 
145                 150                 155                 160 


Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val 
                165                 170                 175     


Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly 
            180                 185                 190         


Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu 
        195                 200                 205             


Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys 
    210                 215                 220                 


Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile 
225                 230                 235                 240 


Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu 
                245                 250                 255 


<210>  948
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  948

Met Ala Pro Asn Ile Tyr Leu Val Arg Gln Arg Ile Ser Arg Leu Gly 
1               5                   10                  15      


Gln Arg Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro 
            20                  25                  30          


Leu Gly Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe 
        35                  40                  45              


Ala Thr Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys 
    50                  55                  60                  


Pro Pro Ala Val Thr Glu Asn Lys Thr Val Thr Ala Thr Phe Gly Tyr 
65                  70                  75                  80  


Pro Phe Arg Leu Asn Glu Ala Ser Phe Gln Pro Pro Pro Gly Val Asn 
                85                  90                  95      


Ile Cys Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser 
            100                 105                 110         


Ser Ser Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr 
        115                 120                 125             


Cys Ile Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu 
    130                 135                 140                 


Asp Ser Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala 
145                 150                 155                 160 


Thr Phe Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr 
                165                 170                 175     


Asp Ile Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro 
            180                 185                 190         


Cys Lys Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met 
        195                 200                 205             


Gly Ser Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu 
    210                 215                 220                 


Trp Gly Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser 
225                 230                 235                 240 


Pro Ser Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro 
                245                 250                 255     


Thr Gly Ile 
            


<210>  949
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  949

Met Ala Glu Leu Leu Ala Ser Ala Gly Ser Ala Cys Ser Trp Asp Phe 
1               5                   10                  15      


Pro Arg Ala Pro Pro Ser Phe Pro Pro Pro Ala Ala Ser Arg Gly Gly 
            20                  25                  30          


Leu Gly Gly Thr Arg Ser Phe Arg Pro His Arg Gly Ala Glu Ser Pro 
        35                  40                  45              


Arg Pro Gly Arg Asp Arg Asp Gly Val Arg Val Pro Met Ala Ser Ser 
    50                  55                  60                  


Arg Cys Pro Ala Pro Arg Gly Cys Arg Cys Leu Pro Gly Ala Ser Leu 
65                  70                  75                  80  


Ala Trp Leu Gly Thr Val Leu Leu Leu Leu Ala Asp Trp Val Leu Leu 
                85                  90                  95      


Arg Thr Ala Leu Pro Arg Ile Phe Ser Leu Leu Val Pro Thr Ala Leu 
            100                 105                 110         


Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg Trp Ala Val Leu 
        115                 120                 125             


Trp Leu Gly Ala Cys Gly Val Leu Arg Ala Thr Val Gly Ser Lys Ser 
    130                 135                 140                 


Glu Asn Ala Gly Ala Gln Gly Trp Leu Ala Ala Leu Lys Pro Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Gly Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu 
                165                 170                 175     


Ile Ser Trp Gly Ala Pro Gly Ser Ala Asp Ser Thr Arg Leu Leu His 
            180                 185                 190         


Trp Gly Ser His Pro Thr Ala Phe Val Val Ser Tyr Ala Ala Ala Leu 
        195                 200                 205             


Pro Ala Ala Ala Leu Trp His Lys Leu Gly Ser Leu Trp Val Pro Gly 
    210                 215                 220                 


Gly Gln Gly Gly Ser Gly Asn Pro Val Arg Arg Leu Leu Gly Cys Leu 
225                 230                 235                 240 


Gly Ser Glu Thr Arg Arg Leu Ser Leu Phe Leu Val Leu Val Val Leu 
                245                 250                 255     


Ser Ser Leu Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Leu Thr 
            260                 265                 270         


Asp Trp Ile Leu Gln Asp Gly Ser Ala Asp Thr Phe Thr Arg Asn Leu 
        275                 280                 285             


Thr Leu Met Ser Ile Leu Thr Ile Ala Ser Ala Val Leu Glu Phe Val 
    290                 295                 300                 


Gly Asp Gly Ile Tyr Asn Asn Thr Met Gly His Val His Ser His Leu 
305                 310                 315                 320 


Gln Gly Glu Val Phe Gly Ala Val Leu Arg Gln Glu Thr Glu Phe Phe 
                325                 330                 335     


Gln Gln Asn Gln Thr Gly Asn Ile Met Ser Arg Val Thr Glu Asp Thr 
            340                 345                 350         


Ser Thr Leu Ser Asp Ser Leu Ser Glu Asn Leu Ser Leu Phe Leu Trp 
        355                 360                 365             


Tyr Leu Val Arg Gly Leu Cys Leu Leu Gly Ile Met Leu Trp Gly Ser 
    370                 375                 380                 


Val Ser Leu Thr Met Val Thr Leu Ile Thr Leu Pro Leu Leu Phe Leu 
385                 390                 395                 400 


Leu Pro Lys Lys Val Gly Lys Trp Tyr Gln Leu Leu Glu Val Gln Val 
                405                 410                 415     


Arg Glu Ser Leu Ala Lys Ser Ser Gln Val Ala Ile Glu Ala Leu Ser 
            420                 425                 430         


Ala Met Pro Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln 
        435                 440                 445             


Lys Phe Arg Glu Lys Leu Gln Glu Ile Lys Thr Leu Asn Gln Lys Glu 
    450                 455                 460                 


Ala Val Ala Tyr Ala Val Asn Ser Trp Thr Thr Ser Ile Ser Gly Met 
465                 470                 475                 480 


Leu Leu Lys Val Gly Ile Leu Tyr Ile Gly Gly Gln Leu Val Thr Ser 
                485                 490                 495     


Gly Ala Val Ser Ser Gly Asn Leu Val Thr Phe Val Leu Tyr Gln Met 
            500                 505                 510         


Gln Phe Thr Gln Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Arg Val 
        515                 520                 525             


Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg 
    530                 535                 540                 


Thr Pro Arg Cys Pro Pro Ser Gly Leu Leu Thr Pro Leu His Leu Glu 
545                 550                 555                 560 


Gly Leu Val Gln Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg Pro 
                565                 570                 575     


Asp Val Leu Val Leu Gln Gly Leu Thr Phe Thr Leu Arg Pro Gly Glu 
            580                 585                 590         


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
        595                 600                 605             


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
    610                 615                 620                 


Asp Gly Lys Pro Leu Pro Gln Tyr Glu His Arg Tyr Leu His Arg Gln 
625                 630                 635                 640 


Val Ala Ala Val Gly Gln Glu Pro Gln Val Phe Gly Arg Ser Leu Gln 
                645                 650                 655     


Glu Asn Ile Ala Tyr Gly Leu Thr Gln Lys Pro Thr Met Glu Glu Ile 
            660                 665                 670         


Thr Ala Ala Ala Val Lys Ser Gly Ala His Ser Phe Ile Ser Gly Leu 
        675                 680                 685             


Pro Gln Gly Tyr Asp Thr Glu Val Asp Glu Ala Gly Ser Gln Leu Ser 
    690                 695                 700                 


Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys 
705                 710                 715                 720 


Pro Cys Val Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Asn 
                725                 730                 735     


Ser Gln Leu Gln Val Glu Gln Leu Leu Tyr Glu Ser Pro Glu Arg Tyr 
            740                 745                 750         


Ser Arg Ser Val Leu Leu Ile Thr Gln His Leu Ser Leu Val Glu Gln 
        755                 760                 765             


Ala Asp His Ile Leu Phe Leu Glu Gly Gly Ala Ile Arg Glu Gly Gly 
    770                 775                 780                 


Thr His Gln Gln Leu Met Glu Lys Lys Gly Cys Tyr Trp Ala Met Val 
785                 790                 795                 800 


Gln Ala Pro Ala Asp Ala Pro Glu 
                805             


<210>  950
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  950

Met Ser His Ala Ala Glu Pro Ala Arg Asp Gly Val Glu Ala Ser Ala 
1               5                   10                  15      


Glu Gly Pro Arg Ala Val Phe Val Leu Leu Glu Glu Arg Arg Pro Ala 
            20                  25                  30          


Asp Ser Ala Gln Leu Leu Ser Leu Asn Ser Leu Leu Pro Glu Ser Gly 
        35                  40                  45              


Ile Val Ala Asp Ile Glu Leu Glu Asn Val Leu Asp Pro Asp Ser Phe 
    50                  55                  60                  


Tyr Glu Leu Lys Ser Gln Pro Leu Pro Leu Arg Ser Ser Leu Pro Ile 
65                  70                  75                  80  


Ser Leu Gln Ala Thr Pro Ala Thr Pro Ala Thr Leu Ser Ala Ser Ser 
                85                  90                  95      


Ser Ala Gly Gly Ser Arg Thr Pro Ala Met Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Arg Val Leu Leu Arg Gln Gln Leu Met Arg Ala Gln Ala Gln Glu Gln 
        115                 120                 125             


Glu Arg Arg Glu Arg Arg Glu Gln Ala Ala Ala Ala Pro Phe Pro Ser 
    130                 135                 140                 


Pro Ala Pro Ala Ser Pro Ala Ile Ser Val Val Gly Val Ser Ala Gly 
145                 150                 155                 160 


Gly His Thr Leu Ser Arg Pro Pro Pro Ala Gln Val Pro Arg Glu Val 
                165                 170                 175     


Leu Lys Val Gln Thr His Leu Glu Asn Pro Thr Arg Tyr His Leu Gln 
            180                 185                 190         


Gln Ala Arg Arg Gln Gln Val Lys Gln Tyr Leu Ser Thr Thr Leu Gly 
        195                 200                 205             


Pro Lys Leu Ala Ser Gln Ala Leu Thr Pro Pro Pro Gly Pro Ala Ser 
    210                 215                 220                 


Ala Gln Pro Leu Pro Ala Pro Glu Ala Ala His Thr Thr Gly Pro Thr 
225                 230                 235                 240 


Gly Ser Ala Pro Asn Ser Pro Met Ala Leu Leu Thr Ile Gly Ser Ser 
                245                 250                 255     


Ser Glu Lys Glu Ile Asp Asp Val Ile Asp Glu Ile Ile Ser Leu Glu 
            260                 265                 270         


Ser Ser Tyr Asn Asp Glu Met Leu Ser Tyr Leu Pro Gly Gly Thr Thr 
        275                 280                 285             


Gly Leu Gln Leu Pro Ser Thr Leu Pro Val Ser Gly Asn Leu Leu Asp 
    290                 295                 300                 


Val Tyr Ser Ser Gln Gly Val Ala Thr Pro Ala Ile Thr Val Ser Asn 
305                 310                 315                 320 


Ser Cys Pro Ala Glu Leu Pro Asn Ile Lys Arg Glu Ile Ser Glu Thr 
                325                 330                 335     


Glu Ala Lys Ala Leu Leu Lys Glu Arg Gln Lys Lys Asp Asn His Asn 
            340                 345                 350         


Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys Glu 
        355                 360                 365             


Leu Gly Thr Leu Ile Pro Lys Ser Ser Asp Pro Glu Met Arg Trp Asn 
    370                 375                 380                 


Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu Gln 
385                 390                 395                 400 


Lys Glu Gln Gln Arg Ser Lys Asp Leu Glu Ser Arg Gln Arg Ser Leu 
                405                 410                 415     


Glu Gln Ala Asn Arg Ser Leu Gln Leu Arg Ile Gln Glu Leu Glu Leu 
            420                 425                 430         


Gln Ala Gln Ile His Gly Leu Pro Val Pro Pro Thr Pro Gly Leu Leu 
        435                 440                 445             


Ser Leu Ala Thr Thr Ser Ala Ser Asp Ser Leu Lys Pro Glu Gln Leu 
    450                 455                 460                 


Asp Ile Glu Glu Glu Gly Arg Pro Gly Ala Ala Thr Phe His Val Gly 
465                 470                 475                 480 


Gly Gly Pro Ala Gln Asn Ala Pro His Gln Gln Pro Pro Ala Pro Pro 
                485                 490                 495     


Ser Asp Ala Leu Leu Asp Leu His Phe Pro Ser Asp His Leu Gly Asp 
            500                 505                 510         


Leu Gly Asp Pro Phe His Leu Gly Leu Glu Asp Ile Leu Met Glu Glu 
        515                 520                 525             


Glu Glu Gly Val Val Gly Gly Leu Ser Gly Gly Ala Leu Ser Pro Leu 
    530                 535                 540                 


Arg Ala Ala Ser Asp Pro Leu Leu Ser Ser Val Ser Pro Ala Val Ser 
545                 550                 555                 560 


Lys Ala Ser Ser Arg Arg Ser Ser Phe Ser Met Glu Glu Glu Ser 
                565                 570                 575 


<210>  951
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  951

Met Ala Ser Arg Ile Gly Leu Arg Met Gln Leu Met Arg Glu Gln Ala 
1               5                   10                  15      


Gln Gln Glu Glu Gln Arg Glu Arg Met Gln Gln Gln Ala Val Met His 
            20                  25                  30          


Tyr Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gly Gly Pro 
        35                  40                  45              


Pro Thr Pro Ala Ile Asn Thr Pro Val His Phe Gln Ser Pro Pro Pro 
    50                  55                  60                  


Val Pro Gly Glu Val Leu Lys Val Gln Ser Tyr Leu Glu Asn Pro Thr 
65                  70                  75                  80  


Ser Tyr His Leu Gln Gln Ser Gln His Gln Lys Val Arg Glu Tyr Leu 
                85                  90                  95      


Ser Glu Thr Tyr Gly Asn Lys Phe Ala Ala His Ile Ser Pro Ala Gln 
            100                 105                 110         


Gly Ser Pro Lys Pro Pro Pro Ala Ala Ser Pro Gly Val Arg Ala Gly 
        115                 120                 125             


His Val Leu Ser Ser Ser Ala Gly Asn Ser Ala Pro Asn Ser Pro Met 
    130                 135                 140                 


Ala Met Leu His Ile Gly Ser Asn Pro Glu Arg Glu Leu Asp Asp Val 
145                 150                 155                 160 


Ile Asp Asn Ile Met Arg Leu Asp Asp Val Leu Gly Tyr Ile Asn Pro 
                165                 170                 175     


Glu Met Gln Met Pro Asn Thr Leu Pro Leu Ser Ser Ser His Leu Asn 
            180                 185                 190         


Val Tyr Ser Ser Asp Pro Gln Val Thr Ala Ser Leu Val Gly Val Thr 
        195                 200                 205             


Ser Ser Ser Cys Pro Ala Asp Leu Thr Gln Lys Arg Glu Leu Thr Asp 
    210                 215                 220                 


Ala Glu Ser Arg Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His 
225                 230                 235                 240 


Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys 
                245                 250                 255     


Glu Leu Gly Met Leu Ile Pro Lys Ala Asn Asp Leu Asp Val Arg Trp 
            260                 265                 270         


Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Arg Met 
        275                 280                 285             


Gln Lys Asp Leu Gln Lys Ser Arg Glu Leu Glu Asn His Ser Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Asn Lys Gln Leu Trp Leu Arg Ile Gln Glu Leu Glu 
305                 310                 315                 320 


Met Gln Ala Arg Val His Gly Leu Pro Thr Thr Ser Pro Ser Gly Met 
                325                 330                 335     


Asn Met Ala Glu Leu Ala Gln Gln Val Val Lys Gln Glu Leu Pro Ser 
            340                 345                 350         


Glu Glu Gly Pro Gly Glu Ala Leu Met Leu Gly Ala Glu Val Pro Asp 
        355                 360                 365             


Pro Glu Pro Leu Pro Ala Leu Pro Pro Gln Ala Pro Leu Pro Leu Pro 
    370                 375                 380                 


Thr Gln Pro Pro Ser Pro Phe His His Leu Asp Phe Ser His Ser Leu 
385                 390                 395                 400 


Ser Phe Gly Gly Arg Glu Asp Glu Gly Pro Pro Gly Tyr Pro Glu Pro 
                405                 410                 415     


Leu Ala Pro Gly His Gly Ser Pro Phe Pro Ser Leu Ser Lys Lys Asp 
            420                 425                 430         


Leu Asp Leu Met Leu Leu Asp Asp Ser Leu Leu Pro Leu Ala Ser Asp 
        435                 440                 445             


Pro Leu Leu Ser Thr Met Ser Pro Glu Ala Ser Lys Ala Ser Ser Arg 
    450                 455                 460                 


Arg Ser Ser Phe Ser Met Glu Glu Gly Asp Val Leu 
465                 470                 475     


<210>  952
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  952

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  953
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  953

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  954
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  954

Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly 
1               5                   10                  15      


Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly 
            20                  25                  30          


Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln 
        35                  40                  45              


Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys 
    50                  55                  60                  


Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr 
65                  70                  75                  80  


Pro Asn Lys Ser Gly Ala Glu Ala Lys Thr Gln Lys Asp Ser Ser Asn 
                85                  90                  95      


Lys Ser Gly Ala Glu Ala Lys Thr Gln Lys Gly Ser Thr Ser Lys Ser 
            100                 105                 110         


Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro 
        115                 120                 125             


Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala 
    130                 135                 140                 


Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Ala Lys Thr 
145                 150                 155                 160 


Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys 
                165                 170                 175     


Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly 
            180                 185                 190         


Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn 
        195                 200                 205             


Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser 
    210                 215                 220                 


Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala 
225                 230                 235                 240 


Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln 
                245                 250                 255     


Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn 
            260                 265                 270         


Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys 
        275                 280                 285             


Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu 
    290                 295                 300                 


Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp 
305                 310                 315                 320 


Val Glu Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly 
                325                 330                 335     


Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser 
            340                 345                 350         


Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp 
        355                 360                 365             


Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His 
    370                 375                 380                 


Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly 
                405                 410                 415     


Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
            420                 425                 430         


Leu Asp Gln Lys Ser 
        435         


<210>  955
<211>  1591
<212>  PRT
<213>  Homo sapiens

<400>  955

Met Gly Asn Ala Glu Ser Gln His Val Glu His Glu Phe Tyr Gly Glu 
1               5                   10                  15      


Lys His Ala Ser Leu Gly Arg Lys His Thr Ser Arg Ser Leu Arg Leu 
            20                  25                  30          


Ser His Lys Thr Arg Arg Thr Arg His Ala Ser Ser Gly Lys Val Ile 
        35                  40                  45              


His Arg Asn Ser Glu Val Ser Thr Arg Ser Ser Ser Thr Pro Ser Ile 
    50                  55                  60                  


Pro Gln Ser Leu Ala Glu Asn Gly Leu Glu Pro Phe Ser Gln Asp Gly 
65                  70                  75                  80  


Thr Leu Glu Asp Phe Gly Ser Pro Ile Trp Val Asp Arg Val Asp Met 
                85                  90                  95      


Gly Leu Arg Pro Val Ser Tyr Thr Asp Ser Ser Val Thr Pro Ser Val 
            100                 105                 110         


Asp Ser Ser Ile Val Leu Thr Ala Ala Ser Val Gln Ser Met Pro Asp 
        115                 120                 125             


Thr Glu Glu Ser Arg Leu Tyr Gly Asp Asp Ala Thr Tyr Leu Ala Glu 
    130                 135                 140                 


Gly Gly Arg Arg Gln His Ser Tyr Thr Ser Asn Gly Pro Thr Phe Met 
145                 150                 155                 160 


Glu Thr Ala Ser Phe Lys Lys Lys Arg Ser Lys Ser Ala Asp Ile Trp 
                165                 170                 175     


Arg Glu Asp Ser Leu Glu Phe Ser Leu Ser Asp Leu Ser Gln Glu His 
            180                 185                 190         


Leu Thr Ser Asn Glu Glu Ile Leu Gly Ser Ala Glu Glu Lys Asp Cys 
        195                 200                 205             


Glu Glu Ala Arg Gly Met Glu Thr Arg Ala Ser Pro Arg Gln Leu Ser 
    210                 215                 220                 


Thr Cys Gln Arg Ala Asn Ser Leu Gly Asp Leu Tyr Ala Gln Lys Asn 
225                 230                 235                 240 


Ser Gly Val Thr Ala Asn Gly Gly Pro Gly Ser Lys Phe Ala Gly Tyr 
                245                 250                 255     


Cys Arg Asn Leu Val Ser Asp Ile Pro Asn Leu Ala Asn His Lys Met 
            260                 265                 270         


Pro Pro Ala Ala Ala Glu Glu Thr Pro Pro Tyr Ser Asn Tyr Asn Thr 
        275                 280                 285             


Leu Pro Cys Arg Lys Ser His Cys Leu Ser Glu Gly Ala Thr Asn Pro 
    290                 295                 300                 


Gln Ile Ser His Ser Asn Ser Met Gln Gly Arg Arg Ala Lys Thr Thr 
305                 310                 315                 320 


Gln Asp Val Asn Ala Gly Glu Gly Ser Glu Phe Ala Asp Ser Gly Ile 
                325                 330                 335     


Glu Gly Ala Thr Thr Asp Thr Asp Leu Leu Ser Arg Arg Ser Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Tyr Ser Pro Thr Thr Gly Arg Ala Phe Val Gly Ser 
        355                 360                 365             


Asp Ser Gly Ser Ser Ser Thr Gly Asp Ala Ala Arg Gln Gly Val Tyr 
    370                 375                 380                 


Glu Asn Phe Arg Arg Glu Leu Glu Met Ser Thr Thr Asn Ser Glu Ser 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Ser Ala His Ser Asp Glu Gln Ser Ser Gly Thr 
                405                 410                 415     


Leu Ser Ser Pro Gly Gln Ser Asp Ile Leu Leu Thr Ala Ala Gln Gly 
            420                 425                 430         


Thr Val Arg Lys Ala Gly Ala Leu Ala Val Lys Asn Phe Leu Val His 
        435                 440                 445             


Lys Lys Asn Lys Lys Val Glu Ser Ala Thr Arg Arg Lys Trp Lys His 
    450                 455                 460                 


Tyr Trp Val Ser Leu Lys Gly Cys Thr Leu Phe Phe Tyr Glu Ser Asp 
465                 470                 475                 480 


Gly Arg Ser Gly Ile Asp His Asn Ser Ile Pro Lys His Ala Val Trp 
                485                 490                 495     


Val Glu Asn Ser Ile Val Gln Ala Val Pro Glu His Pro Lys Lys Asp 
            500                 505                 510         


Phe Val Phe Cys Leu Ser Asn Ser Leu Gly Asp Ala Phe Leu Phe Gln 
        515                 520                 525             


Thr Thr Ser Gln Thr Glu Leu Glu Asn Trp Ile Thr Ala Ile His Ser 
    530                 535                 540                 


Ala Cys Ala Thr Ala Val Ala Arg His His His Lys Glu Asp Thr Leu 
545                 550                 555                 560 


Arg Leu Leu Lys Ser Glu Ile Lys Lys Leu Glu Gln Lys Ile Asp Met 
                565                 570                 575     


Asp Glu Lys Met Lys Lys Met Gly Glu Met Gln Leu Ser Ser Val Thr 
            580                 585                 590         


Asp Ser Lys Lys Lys Lys Thr Ile Leu Asp Gln Ile Phe Val Trp Glu 
        595                 600                 605             


Gln Asn Leu Glu Gln Phe Gln Met Asp Leu Phe Arg Phe Arg Cys Tyr 
    610                 615                 620                 


Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Ala Phe Ala Ser Arg Pro Thr Lys Val Ala Met Gly Arg Leu Gly Ile 
                645                 650                 655     


Phe Ser Val Ser Ser Phe His Ala Leu Val Ala Ala Arg Thr Gly Glu 
            660                 665                 670         


Thr Gly Val Arg Arg Arg Thr Gln Ala Met Ser Arg Ser Ala Ser Lys 
        675                 680                 685             


Arg Arg Ser Arg Phe Ser Ser Leu Trp Gly Leu Asp Thr Thr Ser Lys 
    690                 695                 700                 


Lys Lys Gln Gly Arg Pro Ser Ile Asn Gln Val Phe Gly Glu Gly Thr 
705                 710                 715                 720 


Glu Ala Val Lys Lys Ser Leu Glu Gly Ile Phe Asp Asp Ile Val Pro 
                725                 730                 735     


Asp Gly Lys Arg Glu Lys Glu Val Val Leu Pro Asn Val His Gln His 
            740                 745                 750         


Asn Pro Asp Cys Asp Ile Trp Val His Glu Tyr Phe Thr Pro Ser Trp 
        755                 760                 765             


Phe Cys Leu Pro Asn Asn Gln Pro Ala Leu Thr Val Val Arg Pro Gly 
    770                 775                 780                 


Asp Thr Ala Arg Asp Thr Leu Glu Leu Ile Cys Lys Thr His Gln Leu 
785                 790                 795                 800 


Asp His Ser Ala His Tyr Leu Arg Leu Lys Phe Leu Ile Glu Asn Lys 
                805                 810                 815     


Met Gln Leu Tyr Val Pro Gln Pro Glu Glu Asp Ile Tyr Glu Leu Leu 
            820                 825                 830         


Tyr Lys Glu Ile Glu Ile Cys Pro Lys Val Thr Gln Ser Ile His Ile 
        835                 840                 845             


Glu Lys Ser Asp Thr Ala Ala Asp Thr Tyr Gly Phe Ser Leu Ser Ser 
    850                 855                 860                 


Val Glu Glu Asp Gly Ile Arg Arg Leu Tyr Val Asn Ser Val Lys Glu 
865                 870                 875                 880 


Thr Gly Leu Ala Ser Lys Lys Gly Leu Lys Ala Gly Asp Glu Ile Leu 
                885                 890                 895     


Glu Ile Asn Asn Arg Ala Ala Asp Ala Leu Asn Ser Ser Met Leu Lys 
            900                 905                 910         


Asp Phe Leu Ser Gln Pro Ser Leu Gly Leu Leu Val Arg Thr Tyr Pro 
        915                 920                 925             


Glu Leu Glu Glu Gly Val Glu Leu Leu Glu Ser Pro Pro His Arg Val 
    930                 935                 940                 


Asp Gly Pro Ala Asp Leu Gly Glu Ser Pro Leu Ala Phe Leu Thr Ser 
945                 950                 955                 960 


Asn Pro Gly His Ser Leu Cys Ser Glu Gln Gly Ser Ser Ala Glu Thr 
                965                 970                 975     


Ala Pro Glu Glu Thr Glu Gly Pro Asp Leu Glu Ser Ser Asp Glu Thr 
            980                 985                 990         


Asp His Ser Ser Lys Ser Thr Glu  Gln Val Ala Ala Phe  Cys Arg Ser 
        995                 1000                 1005             


Leu His  Glu Met Asn Pro Ser  Asp Gln Ser Pro Ser  Pro Gln Asp 
    1010                 1015                 1020             


Ser Thr  Gly Pro Gln Leu Ala  Thr Met Arg Gln Leu  Ser Asp Ala 
    1025                 1030                 1035             


Asp Lys  Leu Arg Lys Val Ile  Cys Glu Leu Leu Glu  Thr Glu Arg 
    1040                 1045                 1050             


Thr Tyr  Val Lys Asp Leu Asn  Cys Leu Met Glu Arg  Tyr Leu Lys 
    1055                 1060                 1065             


Pro Leu  Gln Lys Glu Thr Phe  Leu Thr Gln Asp Glu  Leu Asp Val 
    1070                 1075                 1080             


Leu Phe  Gly Asn Leu Thr Glu  Met Val Glu Phe Gln  Val Glu Phe 
    1085                 1090                 1095             


Leu Lys  Thr Leu Glu Asp Gly  Val Arg Leu Val Pro  Asp Leu Glu 
    1100                 1105                 1110             


Lys Leu  Glu Lys Val Asp Gln  Phe Lys Lys Val Leu  Phe Ser Leu 
    1115                 1120                 1125             


Gly Gly  Ser Phe Leu Tyr Tyr  Ala Asp Arg Phe Lys  Leu Tyr Ser 
    1130                 1135                 1140             


Ala Phe  Cys Ala Ser His Thr  Lys Val Pro Lys Val  Leu Val Lys 
    1145                 1150                 1155             


Ala Lys  Thr Asp Thr Ala Phe  Lys Ala Phe Leu Asp  Ala Gln Asn 
    1160                 1165                 1170             


Pro Lys  Gln Gln His Ser Ser  Thr Leu Glu Ser Tyr  Leu Ile Lys 
    1175                 1180                 1185             


Pro Ile  Gln Arg Ile Leu Lys  Tyr Pro Leu Leu Leu  Arg Glu Leu 
    1190                 1195                 1200             


Phe Ala  Leu Thr Asp Ala Glu  Ser Glu Glu His Tyr  His Leu Asp 
    1205                 1210                 1215             


Val Ala  Ile Lys Thr Met Asn  Lys Val Ala Ser His  Ile Asn Glu 
    1220                 1225                 1230             


Met Gln  Lys Ile His Glu Glu  Phe Gly Ala Val Phe  Asp Gln Leu 
    1235                 1240                 1245             


Ile Ala  Glu Gln Thr Gly Glu  Lys Lys Glu Val Ala  Asp Leu Ser 
    1250                 1255                 1260             


Met Gly  Asp Leu Leu Leu His  Thr Thr Val Ile Trp  Leu Asn Pro 
    1265                 1270                 1275             


Pro Ala  Ser Leu Gly Lys Trp  Lys Lys Glu Pro Glu  Leu Ala Ala 
    1280                 1285                 1290             


Phe Val  Phe Lys Thr Ala Val  Val Leu Val Tyr Lys  Asp Gly Ser 
    1295                 1300                 1305             


Lys Gln  Lys Lys Lys Leu Val  Gly Ser His Arg Leu  Ser Ile Tyr 
    1310                 1315                 1320             


Glu Asp  Trp Asp Pro Phe Arg  Phe Arg His Met Ile  Pro Thr Glu 
    1325                 1330                 1335             


Ala Leu  Gln Val Arg Ala Leu  Ala Ser Ala Asp Ala  Glu Ala Asn 
    1340                 1345                 1350             


Ala Val  Cys Glu Ile Val His  Val Lys Ser Glu Ser  Glu Gly Arg 
    1355                 1360                 1365             


Pro Glu  Arg Val Phe His Leu  Cys Cys Ser Ser Pro  Glu Ser Arg 
    1370                 1375                 1380             


Lys Asp  Phe Leu Lys Ala Val  His Ser Ile Leu Arg  Asp Lys His 
    1385                 1390                 1395             


Arg Arg  Gln Leu Leu Lys Thr  Glu Ser Leu Pro Ser  Ser Gln Gln 
    1400                 1405                 1410             


Tyr Val  Pro Phe Gly Gly Lys  Arg Leu Cys Ala Leu  Lys Gly Ala 
    1415                 1420                 1425             


Arg Pro  Ala Met Ser Arg Ala  Val Ser Ala Pro Ser  Lys Ser Leu 
    1430                 1435                 1440             


Gly Arg  Arg Arg Arg Arg Leu  Ala Arg Asn Arg Phe  Thr Ile Asp 
    1445                 1450                 1455             


Ser Asp  Ala Val Ser Ala Ser  Ser Pro Glu Lys Glu  Ser Gln Gln 
    1460                 1465                 1470             


Pro Pro  Gly Gly Gly Asp Thr  Asp Arg Trp Val Glu  Glu Gln Phe 
    1475                 1480                 1485             


Asp Leu  Ala Gln Tyr Glu Glu  Gln Asp Asp Ile Lys  Glu Thr Asp 
    1490                 1495                 1500             


Ile Leu  Ser Asp Asp Asp Glu  Phe Cys Glu Ser Val  Lys Gly Ala 
    1505                 1510                 1515             


Ser Val  Asp Arg Asp Leu Gln  Glu Arg Leu Gln Ala  Thr Ser Ile 
    1520                 1525                 1530             


Ser Gln  Arg Glu Arg Gly Arg  Lys Thr Leu Asp Ser  His Ala Ser 
    1535                 1540                 1545             


Arg Met  Ala Gln Leu Lys Lys  Gln Ala Ala Leu Ser  Gly Ile Asn 
    1550                 1555                 1560             


Gly Gly  Leu Glu Ser Ala Ser  Glu Glu Val Ile Trp  Val Arg Arg 
    1565                 1570                 1575             


Glu Asp  Phe Ala Pro Ser Arg  Lys Leu Asn Thr Glu  Ile 
    1580                 1585                 1590     


<210>  956
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  956

Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile 
            340                 345                 350         


Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala 
        355                 360                 365             


Ala Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr 
    370                 375                 380                 


Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val 
                405                 410                 415     


Ser Phe Gly Ala Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr 
            420                 425                 430         


Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr 
        435                 440                 445             


Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro 
    450                 455                 460                 


His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile 
465                 470                 475                 480 


Asn Thr Leu Ser His Gly Glu Val Val Cys Ala Val Thr Ile Ser Asn 
                485                 490                 495     


Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp 
            500                 505                 510         


Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys 
        515                 520                 525             


Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly 
    530                 535                 540                 


Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp 
545                 550                 555                 560 


Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala 
                565                 570                 575     


Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe 
            580                 585                 590         


Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln 
        595                 600                 605             


Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile 
    610                 615                 620                 


Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn 
625                 630                 635                 640 


Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His 
                645                 650                 655     


Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu 
            660                 665                 670         


Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His 
        675                 680                 685             


Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu 
    690                 695                 700                 


Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys 
705                 710                 715                 720 


Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe 
                725                 730                 735     


Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp 
            740                 745                 750         


Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr 
        755                 760                 765             


Glu Val Ile Tyr 
    770         


<210>  957
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  957

Met Ile Arg Asp Leu Ser Lys Met Tyr Pro Gln Thr Arg His Pro Ala 
1               5                   10                  15      


Pro His Gln Pro Ala Gln Pro Phe Lys Phe Thr Ile Ser Glu Ser Cys 
            20                  25                  30          


Asp Arg Ile Lys Glu Glu Phe Gln Phe Leu Gln Ala Gln Tyr His Ser 
        35                  40                  45              


Leu Lys Leu Glu Cys Glu Lys Leu Ala Ser Glu Lys Thr Glu Met Gln 
    50                  55                  60                  


Arg His Tyr Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu 
65                  70                  75                  80  


Met His Lys Gln Ala Glu Ile Val Lys Arg Leu Asn Ala Ile Cys Ala 
                85                  90                  95      


Gln Val Ile Pro Phe Leu Ser Gln Glu His Gln Gln Gln Val Val Gln 
            100                 105                 110         


Ala Val Glu Arg Ala Lys Gln Val Thr Met Ala Glu Leu Asn Ala Ile 
        115                 120                 125             


Ile Gly Gln Gln Leu Gln Ala Gln His Leu Ser His Gly His Gly Leu 
    130                 135                 140                 


Pro Val Pro Leu Thr Pro His Pro Ser Gly Leu Gln Pro Pro Ala Ile 
145                 150                 155                 160 


Pro Pro Ile Gly Ser Ser Ala Gly Leu Leu Ala Leu Ser Ser Ala Leu 
                165                 170                 175     


Gly Gly Gln Ser His Leu Pro Ile Lys Asp Glu Lys Lys His His Asp 
            180                 185                 190         


Asn Asp His Gln Arg Asp Arg Asp Ser Ile Lys Ser Ser Ser Val Ser 
        195                 200                 205             


Pro Ser Ala Ser Phe Arg Gly Ala Glu Lys His Arg Asn Ser Ala Asp 
    210                 215                 220                 


Tyr Ser Ser Glu Ser Lys Lys Gln Lys Thr Glu Glu Lys Glu Ile Ala 
225                 230                 235                 240 


Ala Arg Tyr Asp Ser Asp Gly Glu Lys Ser Asp Asp Asn Leu Val Val 
                245                 250                 255     


Asp Val Ser Asn Glu Asp Pro Ser Ser Pro Arg Gly Ser Pro Ala His 
            260                 265                 270         


Ser Pro Arg Glu Asn Gly Leu Asp Lys Thr Arg Leu Leu Lys Lys Asp 
        275                 280                 285             


Ala Pro Ile Ser Pro Ala Ser Ile Ala Ser Ser Ser Ser Thr Pro Ser 
    290                 295                 300                 


Ser Lys Ser Lys Glu Leu Ser Leu Asn Glu Lys Ser Thr Thr Pro Val 
305                 310                 315                 320 


Ser Lys Ser Asn Thr Pro Thr Pro Arg Thr Asp Ala Pro Thr Pro Gly 
                325                 330                 335     


Ser Asn Ser Thr Pro Gly Leu Arg Pro Val Pro Gly Lys Pro Pro Gly 
            340                 345                 350         


Val Asp Pro Leu Ala Ser Ser Leu Arg Thr Pro Met Ala Val Pro Cys 
        355                 360                 365             


Pro Tyr Pro Thr Pro Phe Gly Ile Val Pro His Ala Gly Met Asn Gly 
    370                 375                 380                 


Glu Leu Thr Ser Pro Gly Ala Ala Tyr Ala Gly Leu His Asn Ile Ser 
385                 390                 395                 400 


Pro Gln Met Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr 
                405                 410                 415     


Gly Arg Ser Pro Val Val Gly Phe Asp Pro His His His Met Arg Val 
            420                 425                 430         


Pro Ala Ile Pro Pro Asn Leu Thr Gly Ile Pro Gly Gly Lys Pro Ala 
        435                 440                 445             


Tyr Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe 
    450                 455                 460                 


Pro Pro Asp Ala Leu Ile Gly Pro Gly Ile Pro Arg His Ala Arg Gln 
465                 470                 475                 480 


Ile Asn Thr Leu Asn His Gly Glu Val Val Cys Ala Val Thr Ile Ser 
                485                 490                 495     


Asn Pro Thr Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Val 
            500                 505                 510         


Trp Asp Ile Ser His Pro Gly Asn Lys Ser Pro Val Ser Gln Leu Asp 
        515                 520                 525             


Cys Leu Asn Arg Asp Asn Tyr Ile Arg Ser Cys Arg Leu Leu Pro Asp 
    530                 535                 540                 


Gly Arg Thr Leu Ile Val Gly Gly Glu Ala Ser Thr Leu Ser Ile Trp 
545                 550                 555                 560 


Asp Leu Ala Ala Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser 
                565                 570                 575     


Ala Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ser Lys Val Cys 
            580                 585                 590         


Phe Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn 
        595                 600                 605             


Gln Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys 
    610                 615                 620                 


Ile Asp Ile Ser Asn Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp 
625                 630                 635                 640 


Asn Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln 
                645                 650                 655     


His Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly 
            660                 665                 670         


Glu Trp Leu Ala Val Gly Met Glu Asn Ser Asn Val Glu Val Leu His 
        675                 680                 685             


Val Thr Lys Pro Asp Lys Tyr Gln Leu His Leu His Glu Ser Cys Val 
    690                 695                 700                 


Leu Ser Leu Lys Phe Ala His Cys Gly Lys Trp Phe Val Ser Thr Gly 
705                 710                 715                 720 


Lys Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile 
                725                 730                 735     


Phe Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Val 
            740                 745                 750         


Asp Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val 
        755                 760                 765             


Tyr Glu Val Ile Tyr 
    770             


<210>  958
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  958

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  959
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  959

Met Ala Gly Gly Val Leu Pro Leu Arg Gly Leu Arg Ala Leu Cys Arg 
1               5                   10                  15      


Val Leu Leu Phe Leu Ser Gln Phe Cys Ile Leu Ser Gly Gly Glu Ser 
            20                  25                  30          


Thr Glu Ile Pro Pro Tyr Val Met Lys Cys Pro Ser Asn Gly Leu Cys 
        35                  40                  45              


Ser Arg Leu Pro Ala Asp Cys Ile Asp Cys Thr Thr Asn Phe Ser Cys 
    50                  55                  60                  


Thr Tyr Gly Lys Pro Val Thr Phe Asp Cys Ala Val Lys Pro Ser Val 
65                  70                  75                  80  


Thr Cys Val Asp Gln Asp Phe Lys Ser Gln Lys Asn Phe Ile Ile Asn 
                85                  90                  95      


Met Thr Cys Arg Phe Cys Trp Gln Leu Pro Glu Thr Asp Tyr Glu Cys 
            100                 105                 110         


Thr Asn Ser Thr Ser Cys Met Thr Val Ser Cys Pro Arg Gln Arg Tyr 
        115                 120                 125             


Pro Ala Asn Cys Thr Val Arg Asp His Val His Cys Leu Gly Asn Arg 
    130                 135                 140                 


Thr Phe Pro Lys Met Leu Tyr Cys Asn Trp Thr Gly Gly Tyr Lys Trp 
145                 150                 155                 160 


Ser Thr Ala Leu Ala Leu Ser Ile Thr Leu Gly Gly Phe Gly Ala Asp 
                165                 170                 175     


Arg Phe Tyr Leu Gly Gln Trp Arg Glu Gly Leu Gly Lys Leu Phe Ser 
            180                 185                 190         


Phe Gly Gly Leu Gly Ile Trp Thr Leu Ile Asp Val Leu Leu Ile Gly 
        195                 200                 205             


Val Gly Tyr Val Gly Pro Ala Asp Gly Ser Leu Tyr Ile 
    210                 215                 220     


<210>  960
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  960

Met Ser Asn Pro Ser Ala Pro Pro Pro Tyr Glu Asp Arg Asn Pro Leu 
1               5                   10                  15      


Tyr Pro Gly Pro Pro Pro Pro Gly Gly Tyr Gly Gln Pro Ser Val Leu 
            20                  25                  30          


Pro Gly Gly Tyr Pro Ala Tyr Pro Gly Tyr Pro Gln Pro Gly Tyr Gly 
        35                  40                  45              


His Pro Ala Gly Tyr Pro Gln Pro Met Pro Pro Thr His Pro Met Pro 
    50                  55                  60                  


Met Asn Tyr Gly Pro Gly His Gly Tyr Asp Gly Glu Glu Arg Ala Val 
65                  70                  75                  80  


Ser Asp Ser Phe Gly Pro Gly Glu Trp Asp Asp Arg Lys Val Arg His 
                85                  90                  95      


Thr Phe Ile Arg Lys Val Tyr Ser Ile Ile Ser Val Gln Leu Leu Ile 
            100                 105                 110         


Thr Val Ala Ile Ile Ala Ile Phe Thr Phe Val Glu Pro Val Ser Ala 
        115                 120                 125             


Phe Val Arg Arg Asn Val Ala Val Tyr Tyr Val Ser Tyr Ala Val Phe 
    130                 135                 140                 


Val Val Thr Tyr Leu Ile Leu Ala Cys Cys Gln Gly Pro Arg Arg Arg 
145                 150                 155                 160 


Phe Pro Trp Asn Ile Ile Leu Leu Thr Leu Phe Thr Phe Ala Met Gly 
                165                 170                 175     


Phe Met Thr Gly Thr Ile Ser Ser Met Tyr Gln Thr Lys Ala Val Ile 
            180                 185                 190         


Ile Ala Met Ile Ile Thr Ala Val Val Ser Ile Ser Val Thr Ile Phe 
        195                 200                 205             


Cys Phe Gln Thr Lys Val Asp Phe Thr Ser Cys Thr Gly Leu Phe Cys 
    210                 215                 220                 


Val Leu Gly Ile Val Leu Leu Val Thr Gly Ile Val Thr Ser Ile Val 
225                 230                 235                 240 


Leu Tyr Phe Gln Tyr Val Tyr Trp Leu His Met Leu Tyr Ala Ala Leu 
                245                 250                 255     


Gly Ala Ile Cys Phe Thr Leu Phe Leu Ala Tyr Asp Thr Gln Leu Val 
            260                 265                 270         


Leu Gly Asn Arg Lys His Thr Ile Ser Pro Glu Asp Tyr Ile Thr Gly 
        275                 280                 285             


Ala Leu Gln Ile Tyr Thr Asp Ile Ile Tyr Ile Phe Thr Phe Val Leu 
    290                 295                 300                 


Gln Leu Met Gly Asp Arg Asn 
305                 310     


<210>  961
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  961

Met Tyr Ala Pro Gly Gly Ala Gly Leu Pro Gly Gly Arg Arg Arg Arg 
1               5                   10                  15      


Ser Pro Gly Gly Ser Ala Leu Pro Lys Gln Pro Glu Arg Ser Leu Ala 
            20                  25                  30          


Ser Ala Leu Pro Gly Ala Leu Ser Ile Thr Ala Leu Cys Thr Ala Leu 
        35                  40                  45              


Ala Glu Pro Ala Trp Leu His Ile His Gly Gly Thr Cys Ser Arg Gln 
    50                  55                  60                  


Glu Leu Gly Val Ser Asp Val Leu Gly Tyr Val His Pro Asp Leu Leu 
65                  70                  75                  80  


Lys Asp Phe Cys Met Asn Pro Gln Thr Val Leu Leu Leu Arg Val Ile 
                85                  90                  95      


Ala Ala Phe Cys Phe Leu Gly Ile Leu Cys Ser Leu Ser Ala Phe Leu 
            100                 105                 110         


Leu Asp Val Phe Gly Pro Lys His Pro Ala Leu Lys Ile Thr Arg Arg 
        115                 120                 125             


Tyr Ala Phe Ala His Ile Leu Thr Val Leu Gln Cys Ala Thr Val Ile 
    130                 135                 140                 


Gly Phe Ser Tyr Trp Ala Ser Glu Leu Ile Leu Ala Gln Gln Gln Gln 
145                 150                 155                 160 


His Lys Lys Tyr His Gly Ser Gln Val Tyr Val Thr Phe Ala Val Ser 
                165                 170                 175     


Phe Tyr Leu Val Ala Gly Ala Gly Gly Ala Ser Ile Leu Ala Thr Ala 
            180                 185                 190         


Ala Asn Leu Leu Arg His Tyr Pro Thr Glu Glu Glu Glu Gln Ala Leu 
        195                 200                 205             


Glu Leu Leu Ser Glu Met Glu Glu Asn Glu Pro Tyr Pro Ala Glu Tyr 
    210                 215                 220                 


Glu Val Ile Asn Gln Phe Gln Pro Pro Pro Ala Tyr Thr Pro 
225                 230                 235             


<210>  962
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  962

Met Thr Val Gln Arg Leu Val Ala Ala Ala Val Leu Val Ala Leu Val 
1               5                   10                  15      


Ser Leu Ile Leu Asn Asn Val Ala Ala Phe Thr Ser Asn Trp Val Cys 
            20                  25                  30          


Gln Thr Leu Glu Asp Gly Arg Arg Arg Ser Val Gly Leu Trp Arg Ser 
        35                  40                  45              


Cys Trp Leu Val Asp Arg Thr Arg Gly Gly Pro Ser Pro Gly Ala Arg 
    50                  55                  60                  


Ala Gly Gln Val Asp Ala His Asp Cys Glu Ala Leu Gly Trp Gly Ser 
65                  70                  75                  80  


Glu Ala Ala Gly Phe Gln Glu Ser Arg Gly Thr Val Lys Leu Gln Phe 
                85                  90                  95      


Asp Met Met Arg Ala Cys Asn Leu Val Ala Thr Ala Ala Leu Thr Ala 
            100                 105                 110         


Gly Gln Leu Thr Phe Leu Leu Gly Leu Val Gly Leu Pro Leu Leu Ser 
        115                 120                 125             


Pro Asp Ala Pro Cys Trp Glu Glu Ala Met Ala Ala Ala Phe Gln Leu 
    130                 135                 140                 


Ala Ser Phe Val Leu Val Ile Gly Leu Val Thr Phe Tyr Arg Ile Gly 
145                 150                 155                 160 


Pro Tyr Thr Asn Leu Ser Trp Ser Cys Tyr Leu Asn Ile Gly Ala Cys 
                165                 170                 175     


Leu Leu Ala Thr Leu Ala Ala Ala Met Leu Ile Trp Asn Ile Leu His 
            180                 185                 190         


Lys Arg Glu Asp Cys Met Ala Pro Arg Val Ile Val Ile Ser Arg Ser 
        195                 200                 205             


Leu Thr Ala Arg Phe Arg Arg Gly Leu Asp Asn Asp Tyr Val Glu Ser 
    210                 215                 220                 


Pro Cys 
225     


<210>  963
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  963

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  964
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  964

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  965
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  965

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
        595                 600                 605             


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
    610                 615                 620                 


Pro Glu Ser Pro Lys Asn Asp Arg Glu Gly Pro Gln 
625                 630                 635     


<210>  966
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  966

Met Gln Pro Glu Glu Gly Thr Gly Trp Leu Leu Glu Leu Leu Ser Glu 
1               5                   10                  15      


Val Gln Leu Gln Gln Tyr Phe Leu Arg Leu Arg Asp Asp Leu Asn Val 
            20                  25                  30          


Thr Arg Leu Ser His Phe Glu Tyr Val Lys Asn Glu Asp Leu Glu Lys 
        35                  40                  45              


Ile Gly Met Gly Arg Pro Gly Gln Arg Arg Leu Trp Glu Ala Val Lys 
    50                  55                  60                  


Arg Arg Lys Ala Leu Cys Lys Arg Lys Ser Trp Met Ser Lys Val Phe 
65                  70                  75                  80  


Ser Gly Lys Arg Leu Glu Ala Glu Phe Pro Pro His His Ser Gln Ser 
                85                  90                  95      


Thr Phe Arg Lys Thr Ser Pro Ala Pro Gly Gly Pro Ala Gly Glu Gly 
            100                 105                 110         


Pro Leu Gln Ser Leu Thr Cys Leu Ile Gly Glu Lys Asp Leu Arg Leu 
        115                 120                 125             


Leu Glu Lys Leu Gly Asp Gly Ser Phe Gly Val Val Arg Arg Gly Glu 
    130                 135                 140                 


Trp Asp Ala Pro Ser Gly Lys Thr Val Ser Val Ala Val Lys Cys Leu 
145                 150                 155                 160 


Lys Pro Asp Val Leu Ser Gln Pro Glu Ala Met Asp Asp Phe Ile Arg 
                165                 170                 175     


Glu Val Asn Ala Met His Ser Leu Asp His Arg Asn Leu Ile Arg Leu 
            180                 185                 190         


Tyr Gly Val Val Leu Thr Pro Pro Met Lys Met Val Thr Glu Leu Ala 
        195                 200                 205             


Pro Leu Gly Ser Leu Leu Asp Arg Leu Arg Lys His Gln Gly His Phe 
    210                 215                 220                 


Leu Leu Gly Thr Leu Ser Arg Tyr Ala Val Gln Val Ala Glu Gly Met 
225                 230                 235                 240 


Gly Tyr Leu Glu Ser Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg 
                245                 250                 255     


Asn Leu Leu Leu Ala Thr Arg Asp Leu Val Lys Ile Gly Asp Phe Gly 
            260                 265                 270         


Leu Met Arg Ala Leu Pro Gln Asn Asp Asp His Tyr Val Met Gln Glu 
        275                 280                 285             


His Arg Lys Val Pro Phe Ala Trp Cys Ala Pro Glu Ser Leu Lys Thr 
    290                 295                 300                 


Arg Thr Phe Ser His Ala Ser Asp Thr Trp Met Phe Gly Val Thr Leu 
305                 310                 315                 320 


Trp Glu Met Phe Thr Tyr Gly Gln Glu Pro Trp Ile Gly Leu Asn Gly 
                325                 330                 335     


Ser Gln Ile Leu His Lys Ile Asp Lys Glu Gly Glu Arg Leu Pro Arg 
            340                 345                 350         


Pro Glu Asp Cys Pro Gln Asp Ile Tyr Asn Val Met Val Gln Cys Trp 
        355                 360                 365             


Ala His Lys Pro Glu Asp Arg Pro Thr Phe Val Ala Leu Arg Asp Phe 
    370                 375                 380                 


Leu Leu Glu Ala Gln Pro Thr Asp Met Arg Ala Leu Gln Asp Phe Glu 
385                 390                 395                 400 


Glu Pro Asp Lys Leu His Ile Gln Met Asn Asp Val Ile Thr Val Ile 
                405                 410                 415     


Glu Gly Arg Ala Glu Asn Tyr Trp Trp Arg Gly Gln Asn Thr Arg Thr 
            420                 425                 430         


Leu Cys Val Gly Pro Phe Pro Arg Asn Val Val Thr Ser Val Ala Gly 
        435                 440                 445             


Leu Ser Ala Gln Asp Ile Ser Gln Pro Leu Gln Asn Ser Phe Ile His 
    450                 455                 460                 


Thr Gly His Gly Asp Ser Asp Pro Arg His Cys Trp Gly Phe Pro Asp 
465                 470                 475                 480 


Arg Ile Asp Glu Leu Tyr Leu Gly Asn Pro Met Asp Pro Pro Asp Leu 
                485                 490                 495     


Leu Ser Val Glu Leu Ser Thr Ser Arg Pro Pro Gln His Leu Gly Gly 
            500                 505                 510         


Val Lys Lys Pro Thr Tyr Asp Pro Val Ser Glu Asp Gln Asp Pro Leu 
        515                 520                 525             


Ser Ser Asp Phe Lys Arg Leu Gly Leu Arg Lys Pro Gly Leu Pro Arg 
    530                 535                 540                 


Gly Leu Trp Leu Ala Lys Pro Ser Ala Arg Val Pro Gly Thr Lys Ala 
545                 550                 555                 560 


Ser Arg Gly Ser Gly Ala Glu Val Thr Leu Ile Asp Phe Gly Glu Glu 
                565                 570                 575     


Pro Val Val Pro Ala Leu Arg Pro Cys Ala Pro Ser Leu Ala Gln Leu 
            580                 585                 590         


Ala Met Asp Ala Cys Ser Leu Leu Asp Glu Thr Pro Pro Gln Ser Pro 
        595                 600                 605             


Thr Arg Ala Leu Pro Arg Pro Leu His Pro Thr Pro Val Val Asp Trp 
    610                 615                 620                 


Asp Ala Arg Pro Leu Pro Pro Pro Pro Ala Tyr Asp Asp Val Ala Gln 
625                 630                 635                 640 


Asp Glu Asp Asp Phe Glu Ile Cys Ser Ile Asn Ser Thr Leu Val Gly 
                645                 650                 655     


Ala Gly Val Pro Ala Gly Pro Ser Gln Gly Gln Thr Asn Tyr Ala Phe 
            660                 665                 670         


Val Pro Glu Gln Ala Arg Pro Pro Pro Pro Leu Glu Asp Asn Leu Phe 
        675                 680                 685             


Leu Pro Pro Gln Gly Gly Gly Lys Pro Pro Ser Ser Ala Gln Thr Ala 
    690                 695                 700                 


Glu Ile Phe Gln Ala Leu Gln Gln Glu Cys Met Arg Gln Leu Gln Ala 
705                 710                 715                 720 


Pro Ala Gly Ser Pro Ala Pro Ser Pro Ser Pro Gly Gly Asp Asp Lys 
                725                 730                 735     


Pro Gln Val Pro Pro Arg Val Pro Ile Pro Pro Arg Pro Thr Arg Pro 
            740                 745                 750         


His Val Gln Leu Ser Pro Ala Pro Pro Gly Glu Glu Glu Thr Ser Gln 
        755                 760                 765             


Trp Pro Gly Pro Ala Ser Pro Pro Arg Val Pro Pro Arg Glu Pro Leu 
    770                 775                 780                 


Ser Pro Gln Gly Ser Arg Thr Pro Ser Pro Leu Val Pro Pro Gly Ser 
785                 790                 795                 800 


Ser Pro Leu Pro Pro Arg Leu Ser Ser Ser Pro Gly Lys Thr Met Pro 
                805                 810                 815     


Thr Thr Gln Ser Phe Ala Ser Asp Pro Lys Tyr Ala Thr Pro Gln Val 
            820                 825                 830         


Ile Gln Ala Pro Gly Pro Arg Ala Gly Pro Cys Ile Leu Pro Ile Val 
        835                 840                 845             


Arg Asp Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu 
    850                 855                 860                 


Arg Pro Ser Tyr Leu Glu Arg Tyr Gln Arg Phe Leu Arg Glu Ala Gln 
865                 870                 875                 880 


Ser Pro Glu Glu Pro Thr Pro Leu Pro Val Pro Leu Leu Leu Pro Pro 
                885                 890                 895     


Pro Ser Thr Pro Ala Pro Ala Ala Pro Thr Ala Thr Val Arg Pro Met 
            900                 905                 910         


Pro Gln Ala Ala Leu Asp Pro Lys Ala Asn Phe Ser Thr Asn Asn Ser 
        915                 920                 925             


Asn Pro Gly Ala Arg Pro Pro Pro Pro Arg Ala Thr Ala Arg Leu Pro 
    930                 935                 940                 


Gln Arg Gly Cys Pro Gly Asp Gly Pro Glu Ala Gly Arg Pro Ala Asp 
945                 950                 955                 960 


Lys Ile Gln Met Ala Met Val His Gly Val Thr Thr Glu Glu Cys Gln 
                965                 970                 975     


Ala Ala Leu Gln Cys His Gly Trp Ser Val Gln Arg Ala Ala Gln Tyr 
            980                 985                 990         


Leu Lys Val Glu Gln Leu Phe Gly  Leu Gly Leu Arg Pro  Arg Gly Glu 
        995                 1000                 1005             


Cys His  Lys Val Leu Glu Met  Phe Asp Trp Asn Leu  Glu Gln Ala 
    1010                 1015                 1020             


Gly Cys  His Leu Leu Gly Ser  Trp Gly Pro Ala His  His Lys Arg 
    1025                 1030                 1035             


<210>  967
<211>  1723
<212>  PRT
<213>  Homo sapiens

<400>  967

Met Arg Glu Lys Glu Gln Glu Arg Glu Glu Gln Leu Met Glu Asp Lys 
1               5                   10                  15      


Lys Arg Lys Lys Glu Asp Lys Lys Lys Lys Glu Ala Thr Gln Lys Val 
            20                  25                  30          


Thr Glu Gln Lys Thr Lys Val Pro Glu Val Thr Lys Pro Ser Leu Ser 
        35                  40                  45              


Gln Pro Thr Ala Ala Ser Pro Ile Gly Ser Ser Pro Ser Pro Pro Val 
    50                  55                  60                  


Asn Gly Gly Asn Asn Ala Lys Arg Val Ala Val Pro Asn Gly Gln Pro 
65                  70                  75                  80  


Pro Ser Ala Ala Arg Tyr Met Pro Arg Glu Val Pro Pro Arg Phe Arg 
                85                  90                  95      


Cys Gln Gln Asp His Lys Val Leu Leu Lys Arg Gly Gln Pro Pro Pro 
            100                 105                 110         


Pro Ser Cys Met Leu Leu Gly Gly Gly Ala Gly Pro Pro Pro Cys Thr 
        115                 120                 125             


Ala Pro Gly Ala Asn Pro Asn Asn Ala Gln Val Thr Gly Ala Leu Leu 
    130                 135                 140                 


Gln Ser Glu Ser Gly Thr Ala Pro Asp Ser Thr Leu Gly Gly Ala Ala 
145                 150                 155                 160 


Ala Ser Asn Tyr Ala Asn Ser Thr Trp Gly Ser Gly Ala Ser Ser Asn 
                165                 170                 175     


Asn Gly Thr Ser Pro Asn Pro Ile His Ile Trp Asp Lys Val Ile Val 
            180                 185                 190         


Asp Gly Ser Asp Met Glu Glu Trp Pro Cys Ile Ala Ser Lys Asp Thr 
        195                 200                 205             


Glu Ser Ser Ser Glu Asn Thr Thr Asp Asn Asn Ser Ala Ser Asn Pro 
    210                 215                 220                 


Gly Ser Glu Lys Ser Thr Leu Pro Gly Ser Thr Thr Ser Asn Lys Gly 
225                 230                 235                 240 


Lys Gly Ser Gln Cys Gln Ser Ala Ser Ser Gly Asn Glu Cys Asn Leu 
                245                 250                 255     


Gly Val Trp Lys Ser Asp Pro Lys Ala Lys Ser Val Gln Ser Ser Asn 
            260                 265                 270         


Ser Thr Thr Glu Asn Asn Asn Gly Leu Gly Asn Trp Arg Asn Val Ser 
        275                 280                 285             


Gly Gln Asp Arg Ile Gly Pro Gly Ser Gly Phe Ser Asn Phe Asn Pro 
    290                 295                 300                 


Asn Ser Asn Pro Ser Ala Trp Pro Ala Leu Val Gln Glu Gly Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ala Leu Glu Thr Asp Asn Ser Asn Ser Ser Ala Gln Val 
                325                 330                 335     


Ser Thr Val Gly Gln Thr Ser Arg Glu Gln Gln Ser Lys Met Glu Asn 
            340                 345                 350         


Ala Gly Val Asn Phe Val Val Ser Gly Arg Glu Gln Ala Gln Ile His 
        355                 360                 365             


Asn Thr Asp Gly Pro Lys Asn Gly Asn Thr Asn Ser Leu Asn Leu Ser 
    370                 375                 380                 


Ser Pro Asn Pro Met Glu Asn Lys Gly Met Pro Phe Gly Met Gly Leu 
385                 390                 395                 400 


Gly Asn Thr Ser Arg Ser Thr Asp Ala Pro Ser Gln Ser Thr Gly Asp 
                405                 410                 415     


Arg Lys Thr Gly Ser Val Gly Ser Trp Gly Ala Ala Arg Gly Pro Ser 
            420                 425                 430         


Gly Thr Asp Thr Val Ser Gly Gln Ser Asn Ser Gly Asn Asn Gly Asn 
        435                 440                 445             


Asn Gly Lys Glu Arg Glu Asp Ser Trp Lys Gly Ala Ser Val Gln Lys 
    450                 455                 460                 


Ser Thr Gly Ser Lys Asn Asp Ser Trp Asp Asn Asn Asn Arg Ser Thr 
465                 470                 475                 480 


Gly Gly Ser Trp Asn Phe Gly Pro Gln Asp Ser Asn Asp Asn Lys Trp 
                485                 490                 495     


Gly Glu Gly Asn Lys Met Thr Ser Gly Val Ser Gln Gly Glu Trp Lys 
            500                 505                 510         


Gln Pro Thr Gly Ser Asp Glu Leu Lys Ile Gly Glu Trp Ser Gly Pro 
        515                 520                 525             


Asn Gln Pro Asn Ser Ser Thr Gly Ala Trp Asp Asn Gln Lys Gly His 
    530                 535                 540                 


Pro Leu Pro Glu Asn Gln Gly Asn Ala Gln Ala Pro Cys Trp Gly Arg 
545                 550                 555                 560 


Ser Ser Ser Ser Thr Gly Ser Glu Val Gly Gly Gln Ser Thr Gly Ser 
                565                 570                 575     


Asn His Lys Ala Gly Ser Ser Asp Ser His Asn Ser Gly Arg Arg Ser 
            580                 585                 590         


Tyr Arg Pro Thr His Pro Asp Cys Gln Ala Val Leu Gln Thr Leu Leu 
        595                 600                 605             


Ser Arg Thr Asp Leu Asp Pro Arg Val Leu Ser Asn Thr Gly Trp Gly 
    610                 615                 620                 


Gln Thr Gln Ile Lys Gln Asp Thr Val Trp Asp Ile Glu Glu Val Pro 
625                 630                 635                 640 


Arg Pro Glu Gly Lys Ser Asp Lys Gly Thr Glu Gly Trp Glu Ser Ala 
                645                 650                 655     


Ala Thr Gln Thr Lys Asn Ser Gly Gly Trp Gly Asp Ala Pro Ser Gln 
            660                 665                 670         


Ser Asn Gln Met Lys Ser Gly Trp Gly Glu Leu Ser Ala Ser Thr Glu 
        675                 680                 685             


Trp Lys Asp Pro Lys Asn Thr Gly Gly Trp Asn Asp Tyr Lys Asn Asn 
    690                 695                 700                 


Asn Ser Ser Asn Trp Gly Gly Gly Arg Pro Asp Glu Lys Thr Pro Ser 
705                 710                 715                 720 


Ser Trp Asn Glu Asn Pro Ser Lys Asp Gln Gly Trp Gly Gly Gly Arg 
                725                 730                 735     


Gln Pro Asn Gln Gly Trp Ser Ser Gly Lys Asn Gly Trp Gly Glu Glu 
            740                 745                 750         


Val Asp Gln Thr Lys Asn Ser Asn Trp Glu Ser Ser Ala Ser Lys Pro 
        755                 760                 765             


Val Ser Gly Trp Gly Glu Gly Gly Gln Asn Glu Ile Gly Thr Trp Gly 
    770                 775                 780                 


Asn Gly Gly Asn Ala Ser Leu Ala Ser Lys Gly Gly Trp Glu Asp Cys 
785                 790                 795                 800 


Lys Arg Ser Pro Ala Trp Asn Glu Thr Gly Arg Gln Pro Asn Ser Trp 
                805                 810                 815     


Asn Lys Gln His Gln Gln Gln Gln Pro Pro Gln Gln Pro Pro Pro Pro 
            820                 825                 830         


Gln Pro Glu Ala Ser Gly Ser Trp Gly Gly Pro Pro Pro Pro Pro Pro 
        835                 840                 845             


Gly Asn Val Arg Pro Ser Asn Ser Ser Trp Ser Ser Gly Pro Gln Pro 
    850                 855                 860                 


Ala Thr Pro Lys Asp Glu Glu Pro Ser Gly Trp Glu Glu Pro Ser Pro 
865                 870                 875                 880 


Gln Ser Ile Ser Arg Lys Met Asp Ile Asp Asp Gly Thr Ser Ala Trp 
                885                 890                 895     


Gly Asp Pro Asn Ser Tyr Asn Tyr Lys Asn Val Asn Leu Trp Asp Lys 
            900                 905                 910         


Asn Ser Gln Gly Gly Pro Ala Pro Arg Glu Pro Asn Leu Pro Thr Pro 
        915                 920                 925             


Met Thr Ser Lys Ser Ala Ser Asp Ser Lys Ser Met Gln Asp Gly Trp 
    930                 935                 940                 


Gly Glu Ser Asp Gly Pro Val Thr Gly Ala Arg His Pro Ser Trp Glu 
945                 950                 955                 960 


Glu Glu Glu Asp Gly Gly Val Trp Asn Thr Thr Gly Ser Gln Gly Ser 
                965                 970                 975     


Ala Ser Ser His Asn Ser Ala Ser Trp Gly Gln Gly Gly Lys Lys Gln 
            980                 985                 990         


Met Lys Cys Ser Leu Lys Gly Gly  Asn Asn Asp Ser Trp  Met Asn Pro 
        995                 1000                 1005             


Leu Ala  Lys Gln Phe Ser Asn  Met Gly Leu Leu Ser  Gln Thr Glu 
    1010                 1015                 1020             


Asp Asn  Pro Ser Ser Lys Met  Asp Leu Ser Val Gly  Ser Leu Ser 
    1025                 1030                 1035             


Asp Lys  Lys Phe Asp Val Asp  Lys Arg Ala Met Asn  Leu Gly Asp 
    1040                 1045                 1050             


Phe Asn  Asp Ile Met Arg Lys  Asp Arg Ser Gly Phe  Arg Pro Pro 
    1055                 1060                 1065             


Asn Ser  Lys Asp Met Gly Thr  Thr Asp Ser Gly Pro  Tyr Phe Glu 
    1070                 1075                 1080             


Lys Gly  Gly Ser His Gly Leu  Phe Gly Asn Ser Thr  Ala Gln Ser 
    1085                 1090                 1095             


Arg Gly  Leu His Thr Pro Val  Gln Pro Leu Asn Ser  Ser Pro Ser 
    1100                 1105                 1110             


Leu Arg  Ala Gln Val Pro Pro  Gln Phe Ile Ser Pro  Gln Val Ser 
    1115                 1120                 1125             


Ala Ser  Met Leu Lys Gln Phe  Pro Asn Ser Gly Leu  Ser Pro Gly 
    1130                 1135                 1140             


Leu Phe  Asn Val Gly Pro Gln  Leu Ser Pro Gln Gln  Ile Ala Met 
    1145                 1150                 1155             


Leu Ser  Gln Leu Pro Gln Ile  Pro Gln Phe Gln Leu  Ala Cys Gln 
    1160                 1165                 1170             


Leu Leu  Leu Gln Gln Gln Gln  Gln Gln Gln Leu Leu  Gln Asn Gln 
    1175                 1180                 1185             


Arg Lys  Ile Ser Gln Ala Val  Arg Gln Gln Gln Glu  Gln Gln Leu 
    1190                 1195                 1200             


Ala Arg  Met Val Ser Ala Leu  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1205                 1210                 1215             


Arg Gln  Pro Gly Met Lys His  Ser Pro Ser His Pro  Val Gly Pro 
    1220                 1225                 1230             


Lys Pro  His Leu Asp Asn Met  Val Pro Asn Ala Leu  Asn Val Gly 
    1235                 1240                 1245             


Leu Pro  Asp Leu Gln Thr Lys  Gly Pro Ile Pro Gly  Tyr Gly Ser 
    1250                 1255                 1260             


Gly Phe  Ser Ser Gly Gly Met  Asp Tyr Gly Met Val  Gly Gly Lys 
    1265                 1270                 1275             


Glu Ala  Gly Thr Glu Ser Arg  Phe Lys Gln Trp Thr  Ser Met Met 
    1280                 1285                 1290             


Glu Gly  Leu Pro Ser Val Ala  Thr Gln Glu Ala Asn  Met His Lys 
    1295                 1300                 1305             


Asn Gly  Ala Ile Val Ala Pro  Gly Lys Thr Arg Gly  Gly Ser Pro 
    1310                 1315                 1320             


Tyr Asn  Gln Phe Asp Ile Ile  Pro Gly Asp Thr Leu  Gly Gly His 
    1325                 1330                 1335             


Thr Gly  Pro Ala Gly Asp Ser  Trp Leu Pro Ala Lys  Ser Pro Pro 
    1340                 1345                 1350             


Thr Asn  Lys Ile Gly Ser Lys  Ser Ser Asn Ala Ser  Trp Pro Pro 
    1355                 1360                 1365             


Glu Phe  Gln Pro Gly Val Pro  Trp Lys Gly Ile Gln  Asn Ile Asp 
    1370                 1375                 1380             


Pro Glu  Ser Asp Pro Tyr Val  Thr Pro Gly Ser Val  Leu Gly Gly 
    1385                 1390                 1395             


Thr Ala  Thr Ser Pro Ile Val  Asp Thr Asp His Gln  Leu Leu Arg 
    1400                 1405                 1410             


Asp Asn  Thr Thr Gly Ser Asn  Ser Ser Leu Asn Thr  Ser Leu Pro 
    1415                 1420                 1425             


Ser Pro  Gly Ala Trp Pro Tyr  Ser Ala Ser Asp Asn  Ser Phe Thr 
    1430                 1435                 1440             


Asn Val  His Ser Thr Ser Ala  Lys Phe Pro Asp Tyr  Lys Ser Thr 
    1445                 1450                 1455             


Trp Ser  Pro Asp Pro Ile Gly  His Asn Pro Thr His  Leu Ser Asn 
    1460                 1465                 1470             


Lys Met  Trp Lys Asn His Ile  Ser Ser Arg Asn Thr  Thr Pro Leu 
    1475                 1480                 1485             


Pro Arg  Pro Pro Pro Gly Leu  Thr Asn Pro Lys Pro  Ser Ser Pro 
    1490                 1495                 1500             


Trp Ser  Ser Thr Ala Pro Arg  Ser Val Arg Gly Trp  Gly Thr Gln 
    1505                 1510                 1515             


Asp Ser  Arg Leu Ala Ser Ala  Ser Thr Trp Ser Asp  Gly Gly Ser 
    1520                 1525                 1530             


Val Arg  Pro Ser Tyr Trp Leu  Val Leu His Asn Leu  Thr Pro Gln 
    1535                 1540                 1545             


Ile Asp  Gly Ser Thr Leu Arg  Thr Ile Cys Met Gln  His Gly Pro 
    1550                 1555                 1560             


Leu Leu  Thr Phe His Leu Asn  Leu Thr Gln Gly Thr  Ala Leu Ile 
    1565                 1570                 1575             


Arg Tyr  Ser Thr Lys Gln Glu  Ala Ala Lys Ala Gln  Thr Ala Leu 
    1580                 1585                 1590             


His Met  Cys Val Leu Gly Asn  Thr Thr Ile Leu Ala  Glu Phe Ala 
    1595                 1600                 1605             


Thr Asp  Asp Glu Val Ser Arg  Phe Leu Ala Gln Ala  Gln Pro Pro 
    1610                 1615                 1620             


Thr Pro  Ala Ala Thr Pro Ser  Ala Pro Ala Ala Gly  Trp Gln Ser 
    1625                 1630                 1635             


Leu Glu  Thr Gly Gln Asn Gln  Ser Asp Pro Val Gly  Pro Ala Leu 
    1640                 1645                 1650             


Asn Leu  Phe Gly Gly Ser Thr  Gly Leu Gly Gln Trp  Ser Ser Ser 
    1655                 1660                 1665             


Ala Gly  Gly Ser Ser Gly Ala  Asp Leu Ala Gly Ala  Ser Leu Trp 
    1670                 1675                 1680             


Gly Pro  Pro Asn Tyr Ser Ser  Ser Leu Trp Gly Val  Pro Thr Val 
    1685                 1690                 1695             


Glu Asp  Pro His Arg Met Gly  Ser Pro Ala Pro Leu  Leu Pro Gly 
    1700                 1705                 1710             


Asp Leu  Leu Gly Gly Gly Ser  Asp Ser Ile 
    1715                 1720             


<210>  968
<211>  1045
<212>  PRT
<213>  Homo sapiens

<400>  968

Met Gly Ser Gln Pro Pro Leu Gly Ser Pro Leu Ser Arg Glu Glu Gly 
1               5                   10                  15      


Glu Ala Pro Pro Pro Ala Pro Ala Ser Glu Gly Arg Arg Arg Ser Arg 
            20                  25                  30          


Arg Val Arg Leu Arg Gly Ser Cys Arg His Arg Pro Ser Phe Leu Gly 
        35                  40                  45              


Cys Arg Glu Leu Ala Ala Ser Ala Pro Ala Arg Pro Ala Pro Ala Ser 
    50                  55                  60                  


Ser Glu Ile Met Ala Ser Ala Ala Lys Glu Phe Lys Met Asp Asn Phe 
65                  70                  75                  80  


Ser Pro Lys Ala Gly Thr Ser Lys Leu Gln Gln Thr Val Pro Ala Asp 
                85                  90                  95      


Ala Ser Pro Asp Ser Lys Cys Pro Ile Cys Leu Asp Arg Phe Asp Asn 
            100                 105                 110         


Val Ser Tyr Leu Asp Arg Cys Leu His Lys Phe Cys Phe Arg Cys Val 
        115                 120                 125             


Gln Glu Trp Ser Lys Asn Lys Ala Glu Cys Pro Leu Cys Lys Gln Pro 
    130                 135                 140                 


Phe Asp Ser Ile Phe His Ser Val Arg Ala Glu Asp Asp Phe Lys Glu 
145                 150                 155                 160 


Tyr Val Leu Arg Pro Ser Tyr Asn Gly Ser Phe Val Thr Pro Asp Arg 
                165                 170                 175     


Arg Phe Arg Tyr Arg Thr Thr Leu Thr Arg Glu Arg Asn Ala Ser Val 
            180                 185                 190         


Tyr Ser Pro Ser Gly Pro Val Asn Arg Arg Thr Thr Thr Pro Pro Asp 
        195                 200                 205             


Ser Gly Val Leu Phe Glu Gly Leu Gly Ile Ser Thr Arg Pro Arg Asp 
    210                 215                 220                 


Val Glu Ile Pro Gln Phe Met Arg Gln Ile Ala Val Arg Arg Pro Thr 
225                 230                 235                 240 


Thr Ala Asp Glu Arg Ser Leu Arg Lys Ile Gln Glu Gln Asp Ile Ile 
                245                 250                 255     


Asn Phe Arg Arg Thr Leu Tyr Arg Ala Gly Ala Arg Val Arg Asn Ile 
            260                 265                 270         


Glu Asp Gly Gly Arg Tyr Arg Asp Ile Ser Ala Glu Phe Phe Arg Arg 
        275                 280                 285             


Asn Pro Ala Cys Leu His Arg Leu Val Pro Trp Leu Lys Arg Glu Leu 
    290                 295                 300                 


Thr Val Leu Phe Gly Ala His Gly Ser Leu Val Asn Ile Val Gln His 
305                 310                 315                 320 


Ile Ile Met Ser Asn Val Thr Arg Tyr Asp Leu Glu Ser Gln Ala Phe 
                325                 330                 335     


Val Ser Asp Leu Arg Pro Phe Leu Leu Asn Arg Thr Glu His Phe Ile 
            340                 345                 350         


His Glu Phe Ile Ser Phe Ala Arg Ser Pro Phe Asn Met Ala Ala Phe 
        355                 360                 365             


Asp Gln His Ala Asn Tyr Asp Cys Pro Ala Pro Ser Tyr Glu Glu Gly 
    370                 375                 380                 


Ser His Ser Asp Ser Ser Val Ile Thr Ile Ser Pro Asp Glu Ala Glu 
385                 390                 395                 400 


Thr Gln Glu Leu Asp Ile Asn Val Ala Thr Val Ser Gln Ala Pro Trp 
                405                 410                 415     


Asp Asp Glu Thr Pro Gly Pro Ser Tyr Ser Ser Ser Glu Gln Val His 
            420                 425                 430         


Val Thr Met Ser Ser Leu Leu Asn Thr Ser Asp Ser Ser Asp Glu Glu 
        435                 440                 445             


Leu Val Thr Gly Gly Ala Thr Ser Gln Ile Gln Gly Val Gln Thr Asn 
    450                 455                 460                 


Asp Asp Leu Asn Asn Asp Ser Asp Asp Ser Ser Asp Asn Cys Val Ile 
465                 470                 475                 480 


Val Gly Phe Val Lys Pro Leu Ala Glu Arg Thr Pro Glu Leu Val Glu 
                485                 490                 495     


Leu Ser Ser Asp Ser Glu Asp Leu Gly Ser Tyr Glu Lys Met Glu Thr 
            500                 505                 510         


Val Lys Thr Gln Glu Gln Glu Gln Ser Tyr Ser Ser Gly Asp Ser Asp 
        515                 520                 525             


Val Ser Arg Cys Ser Ser Pro His Ser Val Leu Gly Lys Asp Glu Gln 
    530                 535                 540                 


Ile Asn Lys Gly His Cys Asp Ser Ser Thr Arg Ile Lys Ser Lys Lys 
545                 550                 555                 560 


Glu Glu Lys Arg Ser Thr Ser Leu Ser Ser Pro Arg Asn Leu Asn Ser 
                565                 570                 575     


Ser Val Arg Gly Asp Arg Val Tyr Ser Pro Tyr Asn His Arg His Arg 
            580                 585                 590         


Lys Arg Gly Arg Ser Arg Ser Ser Asp Ser Arg Ser Gln Ser Arg Ser 
        595                 600                 605             


Gly His Asp Gln Lys Asn His Arg Lys His His Gly Lys Lys Arg Met 
    610                 615                 620                 


Lys Ser Lys Arg Ser Arg Ser Arg Glu Ser Ser Arg Pro Arg Gly Arg 
625                 630                 635                 640 


Arg Asp Lys Lys Arg Ser Arg Thr Arg Asp Ser Ser Trp Ser Arg Arg 
                645                 650                 655     


Ser Gln Thr Leu Ser Leu Ser Ser Glu Ser Thr Ser Arg Ser Arg Ser 
            660                 665                 670         


Arg Ser Ser Asp His Gly Lys Arg Arg Ser Arg Ser Arg Asn Arg Asp 
        675                 680                 685             


Arg Tyr Tyr Leu Arg Asn Asn Tyr Gly Ser Arg Tyr Lys Trp Glu Tyr 
    690                 695                 700                 


Thr Tyr Tyr Ser Arg Asn Lys Asp Arg Asp Gly Tyr Glu Ser Ser Tyr 
705                 710                 715                 720 


Arg Arg Arg Thr Leu Ser Arg Ala His Tyr Ser Arg Gln Ser Ser Ser 
                725                 730                 735     


Pro Glu Phe Arg Val Gln Ser Phe Ser Glu Arg Thr Asn Ala Arg Lys 
            740                 745                 750         


Lys Asn Asn His Ser Glu Arg Lys Tyr Tyr Tyr Tyr Glu Arg His Arg 
        755                 760                 765             


Ser Arg Ser Leu Ser Ser Asn Arg Ser Arg Thr Ala Ser Thr Gly Thr 
    770                 775                 780                 


Asp Arg Val Arg Asn Glu Lys Pro Gly Gly Lys Arg Lys Tyr Lys Thr 
785                 790                 795                 800 


Arg His Leu Glu Gly Thr Asn Glu Val Ala Gln Pro Ser Arg Glu Phe 
                805                 810                 815     


Ala Ser Lys Ala Lys Asp Ser His Tyr Gln Lys Ser Ser Ser Lys Leu 
            820                 825                 830         


Asp Gly Asn Tyr Lys Asn Glu Ser Asp Thr Phe Ser Asp Ser Arg Ser 
        835                 840                 845             


Ser Asp Arg Glu Thr Lys His Lys Arg Arg Lys Arg Lys Thr Arg Ser 
    850                 855                 860                 


Leu Ser Val Glu Ile Val Tyr Glu Gly Lys Ala Thr Asp Thr Thr Lys 
865                 870                 875                 880 


His His Lys Lys Lys Lys Lys Lys His Lys Lys Lys His Lys Lys His 
                885                 890                 895     


His Gly Asp Asn Ala Ser Arg Ser Pro Val Val Ile Thr Ile Asp Ser 
            900                 905                 910         


Asp Ser Asp Lys Asp Ser Glu Val Lys Glu Asp Thr Glu Cys Asp Asn 
        915                 920                 925             


Ser Gly Pro Gln Asp Pro Leu Gln Asn Glu Phe Leu Ala Pro Ser Leu 
    930                 935                 940                 


Glu Pro Phe Glu Thr Lys Asp Val Val Thr Ile Glu Ala Glu Phe Gly 
945                 950                 955                 960 


Val Leu Asp Lys Glu Cys Asp Ile Ala Thr Leu Ser Asn Asn Leu Asn 
                965                 970                 975     


Asn Ala Asn Lys Thr Val Asp Asn Ile Pro Pro Leu Ala Ala Ser Val 
            980                 985                 990         


Glu Gln Thr Leu Asp Val Arg Glu  Glu Ser Thr Phe Val  Ser Asp Leu 
        995                 1000                 1005             


Glu Asn  Gln Pro Ser Asn Ile  Val Ser Leu Gln Thr  Glu Pro Ser 
    1010                 1015                 1020             


Arg Gln  Leu Pro Ser Pro Arg  Thr Ser Leu Met Ser  Val Cys Leu 
    1025                 1030                 1035             


Gly Arg  Asp Cys Asp Met Ser  
    1040                 1045 


<210>  969
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  969

Met Ser Leu Arg Asp Lys Gly Gly Glu Glu Glu Cys Phe Glu Tyr Asp 
1               5                   10                  15      


Cys Gln Asp Glu Glu Arg Lys Pro Thr His Arg Gln His Asp Thr Gln 
            20                  25                  30          


Asp Leu Leu Glu Glu Val Leu Cys Ala Glu Arg Val Gly Gln Met Thr 
        35                  40                  45              


Lys Thr Tyr Asn Asp Ile Asp Ala Val Thr Arg Leu Leu Glu Glu Lys 
    50                  55                  60                  


Glu Arg Asp Leu Glu Leu Ala Ala Arg Ile Gly Gln Ser Leu Leu Lys 
65                  70                  75                  80  


Lys Asn Lys Thr Leu Thr Glu Arg Asn Glu Leu Leu Glu Glu Gln Val 
                85                  90                  95      


Glu His Ile Arg Glu Glu Val Ser Gln Leu Arg His Glu Leu Ser Met 
            100                 105                 110         


Lys Asp Glu Leu Leu Gln Phe Tyr Thr Ser Ala Ala Glu Glu Ser Glu 
        115                 120                 125             


Pro Glu Ser Val Cys Ser Thr Pro Leu Lys Arg Asn Glu Ser Ser Ser 
    130                 135                 140                 


Ser Val Gln Asn Tyr Phe His Leu Asp Ser Leu Gln Lys Lys Leu Lys 
145                 150                 155                 160 


Asp Leu Glu Glu Glu Asn Val Val Leu Arg Ser Glu Ala Ser Gln Leu 
                165                 170                 175     


Lys Thr Glu Thr Ile Thr Tyr Glu Glu Lys Glu Gln Gln Leu Val Asn 
            180                 185                 190         


Asp Cys Val Lys Glu Leu Arg Asp Ala Asn Val Gln Ile Ala Ser Ile 
        195                 200                 205             


Ser Glu Glu Leu Ala Lys Lys Thr Glu Asp Ala Ala Arg Gln Gln Glu 
    210                 215                 220                 


Glu Ile Thr His Leu Leu Ser Gln Ile Val Asp Leu Gln Lys Lys Ala 
225                 230                 235                 240 


Lys Ala Cys Ala Val Glu Asn Glu Glu Leu Val Gln His Leu Gly Ala 
                245                 250                 255     


Ala Lys Asp Ala Gln Arg Gln Leu Thr Ala Glu Leu Arg Glu Leu Glu 
            260                 265                 270         


Asp Lys Tyr Ala Glu Cys Met Glu Met Leu His Glu Ala Gln Glu Glu 
        275                 280                 285             


Leu Lys Asn Leu Arg Asn Lys Thr Met Pro Asn Thr Thr Ser Arg Arg 
    290                 295                 300                 


Tyr His Ser Leu Gly Leu Phe Pro Met Asp Ser Leu Ala Ala Glu Ile 
305                 310                 315                 320 


Glu Gly Thr Met Arg Lys Glu Leu Gln Leu Glu Glu Ala Glu Ser Pro 
                325                 330                 335     


Asp Ile Thr His Gln Lys Arg Val Phe Glu Thr Val Arg Asn Ile Asn 
            340                 345                 350         


Gln Val Val Lys Gln Arg Ser Leu Thr Pro Ser Pro Met Asn Ile Pro 
        355                 360                 365             


Gly Ser Asn Gln Ser Ser Ala Met Asn Ser Leu Leu Ser Ser Cys Val 
    370                 375                 380                 


Ser Thr Pro Arg Ser Ser Phe Tyr Gly Ser Asp Ile Gly Asn Val Val 
385                 390                 395                 400 


Leu Asp Asn Lys Thr Asn Ser Ile Ile Leu Glu Thr Glu Ala Ala Asp 
                405                 410                 415     


Leu Gly Asn Asp Glu Arg Ser Lys Lys Pro Gly Thr Pro Gly Thr Pro 
            420                 425                 430         


Gly Ser His Asp Leu Glu Thr Ala Leu Arg Arg Leu Ser Leu Arg Arg 
        435                 440                 445             


Glu Asn Tyr Leu Ser Glu Arg Arg Phe Phe Glu Glu Glu Gln Glu Arg 
    450                 455                 460                 


Lys Leu Gln Glu Leu Ala Glu Lys Gly Glu Leu Arg Ser Gly Ser Leu 
465                 470                 475                 480 


Thr Pro Thr Glu Ser Ile Met Ser Leu Gly Thr His Ser Arg Phe Ser 
                485                 490                 495     


Glu Phe Thr Gly Phe Ser Gly Met Ser Phe Ser Ser Arg Ser Tyr Leu 
            500                 505                 510         


Pro Glu Lys Leu Gln Ile Val Lys Pro Leu Glu Gly Ser Ala Thr Leu 
        515                 520                 525             


His His Trp Gln Gln Leu Ala Gln Pro His Leu Gly Gly Ile Leu Asp 
    530                 535                 540                 


Pro Arg Pro Gly Val Val Thr Lys Gly Phe Arg Thr Leu Asp Val Asp 
545                 550                 555                 560 


Leu Asp Glu Val Tyr Cys Leu Asn Asp Phe Glu Glu Asp Asp Thr Gly 
                565                 570                 575     


Asp His Ile Ser Leu Pro Arg Leu Ala Thr Ser Thr Pro Val Gln His 
            580                 585                 590         


Pro Glu Thr Ser Gly Glu Arg Ser Gln Ala Arg Val Thr Val Ser Gly 
        595                 600                 605             


Ser Arg Ser Tyr Pro Ser Arg Pro Gln Ala Ser Pro Glu Glu Met Gln 
    610                 615                 620                 


Glu Pro Pro Ala Ala Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
625                 630                 635                 640 


Gly Ser Gly Glu Gly Thr Thr Ile Ser Pro Val Asn Leu Ala Pro Phe 
                645                 650                 655     


Pro Glu Ala Glu Phe Trp Ala Ile Leu Thr Ser Val Pro Gly Thr Ile 
            660                 665                 670         


Arg Ser Gly Ser Leu Ser Val Ala Ser Ala Arg Leu Cys Gly 
        675                 680                 685     


<210>  970
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  970

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  971
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  971

Met Asn Ile His Arg Ser Thr Pro Ile Thr Ile Ala Arg Tyr Gly Arg 
1               5                   10                  15      


Ser Arg Asn Lys Thr Gln Asp Phe Glu Glu Leu Ser Ser Ile Arg Ser 
            20                  25                  30          


Ala Glu Pro Ser Gln Ser Phe Ser Pro Asn Leu Gly Ser Pro Ser Pro 
        35                  40                  45              


Pro Glu Thr Pro Asn Leu Ser His Cys Val Ser Cys Ile Gly Lys Tyr 
    50                  55                  60                  


Leu Leu Leu Glu Pro Leu Glu Gly Asp His Val Phe Arg Ala Val His 
65                  70                  75                  80  


Leu His Ser Gly Glu Glu Leu Val Cys Lys Val Phe Asp Ile Ser Cys 
                85                  90                  95      


Tyr Gln Glu Ser Leu Ala Pro Cys Phe Cys Leu Ser Ala His Ser Asn 
            100                 105                 110         


Ile Asn Gln Ile Thr Glu Ile Ile Leu Gly Glu Thr Lys Ala Tyr Val 
        115                 120                 125             


Phe Phe Glu Arg Ser Tyr Gly Asp Met His Ser Phe Val Arg Thr Cys 
    130                 135                 140                 


Lys Lys Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Tyr Gln Ile Ala 
145                 150                 155                 160 


Ser Ala Val Ala His Cys His Asp Gly Gly Leu Val Leu Arg Asp Leu 
                165                 170                 175     


Lys Leu Arg Lys Phe Ile Phe Lys Asp Glu Glu Arg Thr Arg Val Lys 
            180                 185                 190         


Leu Glu Ser Leu Glu Asp Ala Tyr Ile Leu Arg Gly Asp Asp Asp Ser 
        195                 200                 205             


Leu Ser Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu 
    210                 215                 220                 


Asn Thr Ser Gly Ser Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu 
225                 230                 235                 240 


Gly Val Met Leu Tyr Thr Met Leu Val Gly Arg Tyr Pro Phe His Asp 
                245                 250                 255     


Ile Glu Pro Ser Ser Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Asn 
            260                 265                 270         


Ile Pro Glu Thr Leu Ser Pro Lys Ala Lys Cys Leu Ile Arg Ser Ile 
        275                 280                 285             


Leu Arg Arg Glu Pro Ser Glu Arg Leu Thr Ser Gln Glu Ile Leu Asp 
    290                 295                 300                 


His Pro Trp Phe Ser Thr Asp Phe Ser Val Ser Asn Ser Ala Tyr Gly 
305                 310                 315                 320 


Ala Lys Glu Val Ser Asp Gln Leu Val Pro Asp Val Asn Met Glu Glu 
                325                 330                 335     


Asn Leu Asp Pro Phe Phe Asn 
            340             


<210>  972
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  972

Met Ala Glu Asn Trp Lys Asn Cys Phe Glu Glu Glu Leu Ile Cys Pro 
1               5                   10                  15      


Ile Cys Leu His Val Phe Val Glu Pro Val Gln Leu Pro Cys Lys His 
            20                  25                  30          


Asn Phe Cys Arg Gly Cys Ile Gly Glu Ala Trp Ala Lys Asp Ser Gly 
        35                  40                  45              


Leu Val Arg Cys Pro Glu Cys Asn Gln Ala Tyr Asn Gln Lys Pro Gly 
    50                  55                  60                  


Leu Glu Lys Asn Leu Lys Leu Thr Asn Ile Val Glu Lys Phe Asn Ala 
65                  70                  75                  80  


Leu His Val Glu Lys Pro Pro Ala Ala Leu His Cys Val Phe Cys Arg 
                85                  90                  95      


Arg Gly Pro Pro Leu Pro Ala Gln Lys Val Cys Leu Arg Cys Glu Ala 
            100                 105                 110         


Pro Cys Cys Gln Ser His Val Gln Thr His Leu Gln Gln Pro Ser Thr 
        115                 120                 125             


Ala Arg Gly His Leu Leu Val Glu Ala Asp Asp Val Arg Ala Trp Ser 
    130                 135                 140                 


Cys Pro Gln His Asn Ala Tyr Arg Leu Tyr His Cys Glu Ala Glu Gln 
145                 150                 155                 160 


Val Ala Val Cys Gln Tyr Cys Cys Tyr Tyr Ser Gly Ala His Gln Gly 
                165                 170                 175     


His Ser Val Cys Asp Val Glu Ile Arg Arg Asn Glu Ile Arg Lys Met 
            180                 185                 190         


Leu Met Lys Gln Gln Asp Arg Leu Glu Glu Arg Glu Gln Asp Ile Glu 
        195                 200                 205             


Asp Gln Leu Tyr Lys Leu Glu Ser Asp Lys Arg Leu Val Glu Glu Lys 
    210                 215                 220                 


Val Asn Gln Leu Lys Glu Glu Val Arg Leu Gln Tyr Glu Lys Leu His 
225                 230                 235                 240 


Gln Leu Leu Asp Glu Asp Leu Arg Gln Thr Val Glu Val Leu Asp Lys 
                245                 250                 255     


Ala Gln Ala Lys Phe Cys Ser Glu Asn Ala Ala Gln Ala Leu His Leu 
            260                 265                 270         


Gly Glu Arg Met Gln Glu Ala Lys Lys Leu Leu Gly Ser Leu Gln Leu 
        275                 280                 285             


Leu Phe Asp Lys Thr Glu Asp Val Ser Phe Met Lys Asn Thr Lys Ser 
    290                 295                 300                 


Val Lys Ile Leu Met Asp Arg Thr Gln Thr Cys Thr Ser Ser Ser Leu 
305                 310                 315                 320 


Ser Pro Thr Lys Ile Gly His Leu Asn Ser Lys Leu Phe Leu Asn Glu 
                325                 330                 335     


Val Ala Lys Lys Glu Lys Gln Leu Arg Lys Met Leu Glu Gly Pro Phe 
            340                 345                 350         


Ser Thr Pro Val Pro Phe Leu Gln Ser Val Pro Leu Tyr Pro Cys Gly 
        355                 360                 365             


Val Ser Ser Ser Gly Ala Glu Lys Arg Lys His Ser Thr Ala Phe Pro 
    370                 375                 380                 


Glu Ala Ser Phe Leu Glu Thr Ser Ser Gly Pro Val Gly Gly Gln Tyr 
385                 390                 395                 400 


Gly Ala Ala Gly Thr Ala Ser Gly Glu Gly Gln Ser Gly Gln Pro Leu 
                405                 410                 415     


Gly Pro Cys Ser Ser Thr Gln His Leu Val Ala Leu Pro Gly Gly Ala 
            420                 425                 430         


Gln Pro Val His Ser Ser Pro Val Phe Pro Pro Ser Gln Tyr Pro Asn 
        435                 440                 445             


Gly Ser Ala Ala Gln Gln Pro Met Leu Pro Gln Tyr Gly Gly Arg Lys 
    450                 455                 460                 


Ile Leu Val Cys Ser Val Asp Asn Cys Tyr Cys Ser Ser Val Ala Asn 
465                 470                 475                 480 


His Gly Gly His Gln Pro Tyr Pro Arg Ser Gly His Phe Pro Trp Thr 
                485                 490                 495     


Val Pro Ser Gln Glu Tyr Ser His Pro Leu Pro Pro Thr Pro Ser Val 
            500                 505                 510         


Pro Gln Ser Leu Pro Ser Leu Ala Val Arg Asp Trp Leu Asp Ala Ser 
        515                 520                 525             


Gln Gln Pro Gly His Gln Asp Phe Tyr Arg Val Tyr Gly Gln Pro Ser 
    530                 535                 540                 


Thr Lys His Tyr Val Thr Ser 
545                 550     


<210>  973
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  973

Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala Cys Glu Arg 
385                 390                 395                 400 


Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met Glu Glu Leu 
                405                 410                 415     


Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln Glu Lys Glu 
            420                 425                 430         


Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala Ile Glu Ala 
        435                 440                 445             


Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu Ser Lys Thr 
    450                 455                 460                 


Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln His Gln Ser 
465                 470                 475                 480 


Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser Glu Gln Tyr 
                485                 490                 495     


Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln Ala Glu Glu 
            500                 505                 510         


Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln Glu Leu Leu 
        515                 520                 525             


Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu Ile Asp Gln 
    530                 535                 540                 


Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly Cys Gly Arg 
545                 550                 555                 560 


Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu Arg Val Lys 
                565                 570                 575     


Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys Leu Arg Asp 
            580                 585                 590         


Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser Gly Lys Tyr 
        595                 600                 605             


Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg Ser Glu Arg 
    610                 615                 620                 


Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met Ala Ala Leu 
625                 630                 635                 640 


Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
                645                 650         


<210>  974
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  974

Met Asn Thr Glu Met Tyr Gln Thr Pro Met Glu Val Ala Val Tyr Gln 
1               5                   10                  15      


Leu His Asn Phe Ser Ile Ser Phe Phe Ser Ser Leu Leu Gly Gly Asp 
            20                  25                  30          


Val Val Ser Val Lys Leu Asp Asn Ser Ala Ser Gly Ala Ser Val Val 
        35                  40                  45              


Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys Asn His 
    50                  55                  60                  


Leu Met Tyr Ala Val Arg Glu Glu Val Glu Ile Leu Lys Glu Gln Ile 
65                  70                  75                  80  


Arg Glu Leu Val Glu Lys Asn Ser Gln Leu Glu Arg Glu Asn Thr Leu 
                85                  90                  95      


Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Glu Lys Phe Gln Ser Cys 
            100                 105                 110         


Leu Ser Pro Glu Glu Pro Ala Pro Glu Ser Pro Gln Val Pro Glu Ala 
        115                 120                 125             


Pro Gly Gly Ser Ala Val 
    130                 


<210>  975
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  975

Met Pro Leu Arg His Trp Gly Met Ala Arg Gly Ser Lys Pro Val Gly 
1               5                   10                  15      


Asp Gly Ala Gln Pro Met Ala Ala Met Gly Gly Leu Lys Val Leu Leu 
            20                  25                  30          


His Trp Ala Gly Pro Gly Gly Gly Glu Pro Trp Val Thr Phe Ser Glu 
        35                  40                  45              


Ser Ser Leu Thr Ala Glu Glu Val Cys Ile His Ile Ala His Lys Val 
    50                  55                  60                  


Gly Ile Thr Pro Pro Cys Phe Asn Leu Phe Ala Leu Phe Asp Ala Gln 
65                  70                  75                  80  


Ala Gln Val Trp Leu Pro Pro Asn His Ile Leu Glu Ile Pro Arg Asp 
                85                  90                  95      


Ala Ser Leu Met Leu Tyr Phe Arg Ile Arg Phe Tyr Phe Arg Asn Trp 
            100                 105                 110         


His Gly Met Asn Pro Arg Glu Pro Ala Val Tyr Arg Cys Gly Pro Pro 
        115                 120                 125             


Gly Thr Glu Ala Ser Ser Asp Gln Thr Ala Gln Gly Met Gln Leu Leu 
    130                 135                 140                 


Asp Pro Ala Ser Phe Glu Tyr Leu Phe Glu Gln Gly Lys His Glu Phe 
145                 150                 155                 160 


Val Asn Asp Val Ala Ser Leu Trp Glu Leu Ser Thr Glu Glu Glu Ile 
                165                 170                 175     


His His Phe Lys Asn Glu Ser Leu Gly Met Ala Phe Leu His Leu Cys 
            180                 185                 190         


His Leu Ala Leu Arg His Gly Ile Pro Leu Glu Glu Val Ala Lys Lys 
        195                 200                 205             


Thr Ser Phe Lys Asp Cys Ile Pro Arg Ser Phe Arg Arg His Ile Arg 
    210                 215                 220                 


Gln His Ser Ala Leu Thr Arg Leu Arg Leu Arg Asn Val Phe Arg Arg 
225                 230                 235                 240 


Phe Leu Arg Asp Phe Gln Pro Gly Arg Leu Ser Gln Gln Met Val Met 
                245                 250                 255     


Val Lys Tyr Leu Ala Thr Leu Glu Arg Leu Ala Pro Arg Phe Gly Thr 
            260                 265                 270         


Glu Arg Val Pro Val Cys His Leu Arg Leu Leu Ala Gln Ala Glu Gly 
        275                 280                 285             


Glu Pro Cys Tyr Ile Arg Asp Ser Gly Val Ala Pro Thr Asp Pro Gly 
    290                 295                 300                 


Pro Glu Ser Ala Ala Gly Pro Pro Thr His Glu Val Leu Val Thr Gly 
305                 310                 315                 320 


Thr Gly Gly Ile Gln Trp Trp Pro Val Glu Glu Glu Val Asn Lys Glu 
                325                 330                 335     


Glu Gly Ser Ser Gly Ser Ser Gly Arg Asn Pro Gln Ala Ser Leu Phe 
            340                 345                 350         


Gly Lys Lys Ala Lys Ala His Lys Ala Val Gly Gln Pro Ala Asp Arg 
        355                 360                 365             


Pro Arg Glu Pro Leu Trp Ala Tyr Phe Cys Asp Phe Arg Asp Ile Thr 
    370                 375                 380                 


His Val Val Leu Lys Glu His Cys Val Ser Ile His Arg Gln Asp Asn 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Ser Leu Pro Ser Arg Ala Ala Ala Leu Ser Phe 
                405                 410                 415     


Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ser Ser His 
            420                 425                 430         


Tyr Leu Cys His Glu Val Ala Pro Pro Arg Leu Val Met Ser Ile Arg 
        435                 440                 445             


Asp Gly Ile His Gly Pro Leu Leu Glu Pro Phe Val Gln Ala Lys Leu 
    450                 455                 460                 


Arg Pro Glu Asp Gly Leu Tyr Leu Ile His Trp Ser Thr Ser His Pro 
465                 470                 475                 480 


Tyr Arg Leu Ile Leu Thr Val Ala Gln Arg Ser Gln Ala Pro Asp Gly 
                485                 490                 495     


Met Gln Ser Leu Arg Leu Arg Lys Phe Pro Ile Glu Gln Gln Asp Gly 
            500                 505                 510         


Ala Phe Val Leu Glu Gly Trp Gly Arg Ser Phe Pro Ser Val Arg Glu 
        515                 520                 525             


Leu Gly Ala Ala Leu Gln Gly Cys Leu Leu Arg Ala Gly Asp Asp Cys 
    530                 535                 540                 


Phe Ser Leu Arg Arg Cys Cys Leu Pro Gln Pro Gly Glu Thr Ser Asn 
545                 550                 555                 560 


Leu Ile Ile Met Arg Gly Ala Arg Ala Ser Pro Arg Thr Leu Asn Leu 
                565                 570                 575     


Ser Gln Leu Ser Phe His Arg Val Asp Gln Lys Glu Ile Thr Gln Leu 
            580                 585                 590         


Ser His Leu Gly Gln Gly Thr Arg Thr Asn Val Tyr Glu Gly Arg Leu 
        595                 600                 605             


Arg Val Glu Gly Ser Gly Asp Pro Glu Glu Gly Lys Met Asp Asp Glu 
    610                 615                 620                 


Asp Pro Leu Val Pro Gly Arg Asp Arg Gly Gln Glu Leu Arg Val Val 
625                 630                 635                 640 


Leu Lys Val Leu Asp Pro Ser His His Asp Ile Ala Leu Ala Phe Tyr 
                645                 650                 655     


Glu Thr Ala Ser Leu Met Ser Gln Val Ser His Thr His Leu Ala Phe 
            660                 665                 670         


Val His Gly Val Cys Val Arg Gly Pro Glu Asn Ile Met Val Thr Glu 
        675                 680                 685             


Tyr Val Glu His Gly Pro Leu Asp Val Trp Leu Arg Arg Glu Arg Gly 
    690                 695                 700                 


His Val Pro Met Ala Trp Lys Met Val Val Ala Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Ala Leu Ser Tyr Leu Glu Asn Lys Asn Leu Val His Gly Asn Val Cys 
                725                 730                 735     


Gly Arg Asn Ile Leu Leu Ala Arg Leu Gly Leu Ala Glu Gly Thr Ser 
            740                 745                 750         


Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Gly Leu Gly Ala Leu Ser 
        755                 760                 765             


Arg Glu Glu Arg Val Glu Arg Ile Pro Trp Leu Ala Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gly Gly Ala Asn Ser Leu Ser Thr Ala Met Asp Lys Trp Gly Phe 
785                 790                 795                 800 


Gly Ala Thr Leu Leu Glu Ile Cys Phe Asp Gly Glu Ala Pro Leu Gln 
                805                 810                 815     


Ser Arg Ser Pro Ser Glu Lys Glu His Phe Tyr Gln Arg Gln His Arg 
            820                 825                 830         


Leu Pro Glu Pro Ser Cys Pro Gln Leu Ala Thr Leu Thr Ser Gln Cys 
        835                 840                 845             


Leu Thr Tyr Glu Pro Thr Gln Arg Pro Ser Phe Arg Thr Ile Leu Arg 
    850                 855                 860                 


Asp Leu Thr Arg Leu Gln Pro His Asn Leu Ala Asp Val Leu Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ser Pro Ala Ser Asp Pro Thr Val Phe His Lys Arg Tyr 
                885                 890                 895     


Leu Lys Lys Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Ser 
            900                 905                 910         


Leu Tyr Cys Tyr Asp Pro Thr Asn Asp Gly Thr Gly Glu Met Val Ala 
        915                 920                 925             


Val Lys Ala Leu Lys Ala Asp Cys Gly Pro Gln His Arg Ser Gly Trp 
    930                 935                 940                 


Lys Gln Glu Ile Asp Ile Leu Arg Thr Leu Tyr His Glu His Ile Ile 
945                 950                 955                 960 


Lys Tyr Lys Gly Cys Cys Glu Asp Gln Gly Glu Lys Ser Leu Gln Leu 
                965                 970                 975     


Val Met Glu Tyr Val Pro Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
            980                 985                 990         


His Ser Ile Gly Leu Ala Gln Leu  Leu Leu Phe Ala Gln  Gln Ile Cys 
        995                 1000                 1005             


Glu Gly  Met Ala Tyr Leu His  Ala Gln His Tyr Ile  His Arg Asp 
    1010                 1015                 1020             


Leu Ala  Ala Arg Asn Val Leu  Leu Asp Asn Asp Arg  Leu Val Lys 
    1025                 1030                 1035             


Ile Gly  Asp Phe Gly Leu Ala  Lys Ala Val Pro Glu  Gly His Glu 
    1040                 1045                 1050             


Tyr Tyr  Arg Val Arg Glu Asp  Gly Asp Ser Pro Val  Phe Trp Tyr 
    1055                 1060                 1065             


Ala Pro  Glu Cys Leu Lys Glu  Tyr Lys Phe Tyr Tyr  Ala Ser Asp 
    1070                 1075                 1080             


Val Trp  Ser Phe Gly Val Thr  Leu Tyr Glu Leu Leu  Thr His Cys 
    1085                 1090                 1095             


Asp Ser  Ser Gln Ser Pro Pro  Thr Lys Phe Leu Glu  Leu Ile Gly 
    1100                 1105                 1110             


Ile Ala  Gln Gly Gln Met Thr  Val Leu Arg Leu Thr  Glu Leu Leu 
    1115                 1120                 1125             


Glu Arg  Gly Glu Arg Leu Pro  Arg Pro Asp Lys Cys  Pro Cys Glu 
    1130                 1135                 1140             


Val Tyr  His Leu Met Lys Asn  Cys Trp Glu Thr Glu  Ala Ser Phe 
    1145                 1150                 1155             


Arg Pro  Thr Phe Glu Asn Leu  Ile Pro Ile Leu Lys  Thr Val His 
    1160                 1165                 1170             


Glu Lys  Tyr Gln Gly Gln Ala  Pro Ser Val Phe Ser  Val Cys 
    1175                 1180                 1185         


<210>  976
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  976

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  977
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  977

Met Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp 
1               5                   10                  15      


Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              


Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             


Thr Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met 
145         


<210>  978
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  978

Met Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys 
1               5                   10                  15      


Lys Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val 
            20                  25                  30          


Leu Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu 
        35                  40                  45              


Lys Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  


Glu Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys 
                85                  90                  95      


Pro Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val 
            100                 105                 110         


Asn Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu 
        115                 120                 125             


Leu Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Leu Arg Phe Gly Val Asp Arg Pro Ser 
145                 150             


<210>  979
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  979

Met Ser Glu Pro His Arg Val Gln Phe Thr Ser Leu Pro Gly Ser Leu 
1               5                   10                  15      


Asn Pro Ala Phe Leu Lys Lys Ser Arg Lys Glu Glu Ala Gly Ala Gly 
            20                  25                  30          


Glu Gln His Gln Asp Cys Glu Pro Ala Ala Ala Ala Val Arg Ile Thr 
        35                  40                  45              


Leu Thr Leu Phe Glu Pro Asp His Lys Arg Cys Pro Glu Phe Phe Tyr 
    50                  55                  60                  


Pro Glu Leu Val Lys Asn Ile Arg Gly Lys Val Lys Gly Leu Gln Pro 
65                  70                  75                  80  


Gly Asp Lys Lys Lys Asp Leu Ser Asp Pro Phe Asn Asp Glu Glu Lys 
                85                  90                  95      


Glu Arg His Lys Val Glu Ala Leu Ala Arg Lys Phe Glu Glu Lys Tyr 
            100                 105                 110         


Gly Gly Lys Lys Arg Arg Lys Asp Arg Ile Gln Asp Leu Ile Asp Met 
        115                 120                 125             


Gly Tyr Gly Tyr Asp Glu Ser Asp Ser Phe Ile Asp Asn Ser Glu Ala 
    130                 135                 140                 


Tyr Asp Glu Leu Val Pro Ala Ser Leu Thr Thr Lys Tyr Gly Gly Phe 
145                 150                 155                 160 


Tyr Ile Asn Ser Gly Thr Leu Gln Phe Arg Gln Ala Ser Glu Ser Glu 
                165                 170                 175     


Asp Asp Phe Ile Lys Glu Lys Lys Lys Lys Ser Pro Lys Lys Arg Lys 
            180                 185                 190         


Leu Lys Glu Gly Gly Glu Lys Ile Lys Lys Lys Lys Lys Asp Asp Thr 
        195                 200                 205             


Tyr Asp Lys Glu Lys Lys Ser Lys Lys Ser Lys Phe Ser Lys Ala Gly 
    210                 215                 220                 


Phe Thr Ala Leu Asn Ala Ser Lys Glu Lys Lys Lys Lys Lys Tyr Ser 
225                 230                 235                 240 


Gly Ala Leu Ser Val Lys Glu Met Leu Lys Lys Phe Gln Lys Glu Lys 
                245                 250                 255     


Glu Ala Gln Lys Lys Arg Glu Glu Glu His Lys Pro Val Ala Val Pro 
            260                 265                 270         


Ser Ala Glu Ala Gln Gly Leu Arg Glu Leu Glu Gly Ala Ser Asp Pro 
        275                 280                 285             


Leu Leu Ser Leu Phe Gly Ser Thr Ser Asp Asn Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Thr Ala Met Asp Ser Leu Thr Asp Leu Asp Leu Glu His Leu Leu 
305                 310                 315                 320 


Ser Glu Ser Pro Glu Gly Ser Pro Phe Arg Asp Met Asp Asp Gly Ser 
                325                 330                 335     


Asp Ser Leu Gly Val Gly Leu Asp Gln Glu Phe Arg Gln Pro Ser Ser 
            340                 345                 350         


Leu Pro Glu Gly Leu Pro Ala Pro Leu Glu Lys Arg Val Lys Glu Leu 
        355                 360                 365             


Ala Gln Ala Ala Arg Ala Ala Glu Gly Glu Ser Arg Gln Lys Phe Phe 
    370                 375                 380                 


Thr Gln Asp Ile Asn Gly Ile Leu Leu Asp Ile Glu Ala Gln Thr Arg 
385                 390                 395                 400 


Glu Leu Ser Ser Gln Val Arg Ser Gly Val Tyr Ala Tyr Leu Ala Ser 
                405                 410                 415     


Phe Leu Pro Cys Ser Lys Asp Ala Leu Leu Lys Arg Ala Arg Lys Leu 
            420                 425                 430         


His Leu Tyr Glu Gln Gly Gly Arg Leu Lys Glu Pro Leu Gln Lys Leu 
        435                 440                 445             


Lys Glu Ala Ile Gly Arg Ala Met Pro Glu Gln Met Ala Lys Tyr Gln 
    450                 455                 460                 


Asp Glu Cys Gln Ala His Thr Gln Ala Lys Val Ala Lys Met Leu Glu 
465                 470                 475                 480 


Glu Glu Lys Asp Lys Glu Gln Arg Asp Arg Ile Cys Ser Asp Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Lys Gly Gly Arg Arg Ile Met Gly Pro Arg Lys Lys 
            500                 505                 510         


Phe Gln Trp Asn Asp Glu Ile Arg Glu Leu Leu Cys Gln Val Val Lys 
        515                 520                 525             


Ile Lys Leu Glu Ser Gln Asp Leu Glu Arg Asn Asn Lys Ala Gln Ala 
    530                 535                 540                 


Trp Glu Asp Cys Val Lys Gly Phe Leu Asp Ala Glu Val Lys Pro Leu 
545                 550                 555                 560 


Trp Pro Lys Gly Trp Met Gln Ala Arg Thr Leu Phe Lys Glu Ser Arg 
                565                 570                 575     


Arg Gly His Gly His Leu Thr Ser Ile Leu Ala Lys Lys Lys Val Met 
            580                 585                 590         


Ala Pro Ser Lys Ile Lys Val Lys Glu Ser Ser Thr Lys Pro Asp Lys 
        595                 600                 605             


Lys Val Ser Val Pro Ser Gly Gln Ile Gly Gly Pro Ile Ala Leu Pro 
    610                 615                 620                 


Ser Asp His Gln Thr Gly Gly Leu Ser Ile Gly Ala Ser Ser Arg Glu 
625                 630                 635                 640 


Leu Pro Ser Gln Ala Ser Gly Gly Leu Ala Asn Pro Pro Pro Val Asn 
                645                 650                 655     


Leu Glu Asp Ser Leu Asp Glu Asp Leu Ile Arg Asn Pro Ala Ser Ser 
            660                 665                 670         


Val Glu Ala Val Ser Lys Glu Leu Ala Ala Leu Asn Ser Arg Ala Ala 
        675                 680                 685             


Gly Asn Ser Glu Phe Thr Leu Pro Ala Pro Ser Lys Ala Pro Ala Glu 
    690                 695                 700                 


Lys Val Gly Gly Val Leu Cys Thr Glu Glu Lys Arg Asn Phe Ala Lys 
705                 710                 715                 720 


Pro Ser Pro Ser Ala Pro Pro Pro Ala Ser Ser Leu Gln Ser Pro Leu 
                725                 730                 735     


Asn Phe Leu Ala Glu Gln Ala Leu Ala Leu Gly Gln Ser Ser Gln Glu 
            740                 745                 750         


Lys Lys Pro Glu Ser Ser Gly Tyr Lys Glu Leu Ser Cys Gln Ala Pro 
        755                 760                 765             


Leu Asn Lys Gly Leu Pro Glu Val His Gln Ser Lys Ala Lys His His 
    770                 775                 780                 


Ser Leu Pro Arg Thr Ser His Gly Pro Gln Val Ala Val Pro Val Pro 
785                 790                 795                 800 


Gly Pro Gln Val Lys Val Phe His Ala Gly Thr Gln Gln Gln Lys Asn 
                805                 810                 815     


Phe Thr Pro Pro Ser Pro Phe Ala Asn Lys Leu Gln Gly Pro Lys Ala 
            820                 825                 830         


Ser Pro Thr Gln Cys His Arg Ser Leu Leu Gln Leu Val Lys Thr Ala 
        835                 840                 845             


Ala Lys Gly Gln Gly Phe His Pro Ser Ala Pro Ala Thr Ser Gly Gly 
    850                 855                 860                 


Leu Ser Ala Ser Ser Ser Ser Ser His Lys Thr Pro Ala Ser Ser Ser 
865                 870                 875                 880 


Ser Ala Leu Ser His Pro Ala Lys Pro His Ser Val Ser Ser Ala Gly 
                885                 890                 895     


Ser Ser Tyr Lys Asn Asn Pro Phe Ala Ser Ser Ile Ser Lys His Gly 
            900                 905                 910         


Val Ser Ser Gly Ser Ser Ser Ser Gly Gly Thr Pro Val Gln Ser Ser 
        915                 920                 925             


Val Ser Gly Ser Leu Val Pro Gly Ile Gln Pro Pro Ser Val Gly Gln 
    930                 935                 940                 


Ala Thr Ser Arg Pro Val Pro Ser Ser Ala Gly Lys Lys Met Pro Val 
945                 950                 955                 960 


Ser Gln Lys Leu Thr Leu Val Ala Pro Pro Gly Gly Pro Asn Gly Asp 
                965                 970                 975     


Ser Ser Gly Gly Thr Gln Gly Val Ala Lys Leu Leu Thr Ser Pro Ser 
            980                 985                 990         


Leu Lys Pro Ser Ala Val Ser Ser  Val Thr Ser Ser Thr  Ser Leu Ser 
        995                 1000                 1005             


Lys Gly  Ala Ser Gly Thr Val  Leu Leu Ala Gly Ser  Ser Leu Met 
    1010                 1015                 1020             


Ala Ser  Pro Tyr Lys Ser Ser  Ser Pro Lys Leu Ser  Gly Ala Met 
    1025                 1030                 1035             


Ser Ser  Asn Ser Leu Gly Ile  Ile Thr Pro Val Pro  Ile Pro Val 
    1040                 1045                 1050             


His Val  Leu Ser Phe Ser Ala  Asp Ser Ser Ala Lys  Ala Gly Val 
    1055                 1060                 1065             


Ser Lys  Asp Ala Ile Val Thr  Gly Pro Ala Pro Gly  Ser Phe His 
    1070                 1075                 1080             


His Gly  Leu Gly His Ser Leu  Leu Ala Gly Leu His  Ser Ser Pro 
    1085                 1090                 1095             


Pro His  Ala Ala Pro Leu Pro  His Ala Ala Val Pro  Thr His Ile 
    1100                 1105                 1110             


Pro Gln  Ser Leu Pro Gly Ala  Ser Gln Leu His Gly  Lys Gly Pro 
    1115                 1120                 1125             


Ala Val  Pro Arg Lys Leu 
    1130                 


<210>  980
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  980

Met Ala Glu Asn Gly Glu Ser Ser Gly Pro Pro Arg Pro Ser Arg Gly 
1               5                   10                  15      


Pro Ala Ala Ala Gln Gly Ser Ala Ala Ala Pro Ala Glu Pro Lys Ile 
            20                  25                  30          


Ile Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu Glu Phe Ala Val 
        35                  40                  45              


Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Ala Ile Ser Lys Arg 
    50                  55                  60                  


Phe Lys Ser Gln Thr Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile 
65                  70                  75                  80  


Leu Lys Asp Gln Asp Thr Leu Ile Gln His Gly Ile His Asp Gly Leu 
                85                  90                  95      


Thr Val His Leu Val Ile Lys Ser Gln Asn Arg Pro Gln Gly Gln Ser 
            100                 105                 110         


Thr Gln Pro Ser Asn Ala Ala Gly Thr Asn Thr Thr Ser Ala Ser Thr 
        115                 120                 125             


Pro Arg Ser Asn Ser Thr Pro Ile Ser Thr Asn Ser Asn Pro Phe Gly 
    130                 135                 140                 


Leu Gly Ser Leu Gly Gly Leu Ala Gly Leu Ser Ser Leu Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln Gln Gln Leu Met 
                165                 170                 175     


Ala Ser Pro Glu Met Met Ile Gln Ile Met Glu Asn Pro Phe Val Gln 
            180                 185                 190         


Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu Ile Met Ala Asn 
        195                 200                 205             


Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu Ile Ser His Leu 
    210                 215                 220                 


Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu Ile Ala Arg Asn 
225                 230                 235                 240 


Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp Leu Ala Leu Ser 
                245                 250                 255     


Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr 
            260                 265                 270         


Thr Asp Ile Gln Glu Pro Met Leu Asn Ala Ala Gln Glu Gln Phe Gly 
        275                 280                 285             


Gly Asn Pro Phe Ala Ser Val Gly Ser Ser Ser Ser Ser Gly Glu Gly 
    290                 295                 300                 


Thr Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu Pro Asn Pro Trp 
305                 310                 315                 320 


Ala Pro Pro Pro Ala Thr Gln Ser Ser Ala Thr Thr Ser Thr Thr Thr 
                325                 330                 335     


Ser Thr Gly Ser Gly Ser Gly Asn Ser Ser Ser Asn Ala Thr Gly Asn 
            340                 345                 350         


Thr Val Ala Ala Ala Asn Tyr Val Ala Ser Ile Phe Ser Thr Pro Gly 
        355                 360                 365             


Met Gln Ser Leu Leu Gln Gln Ile Thr Glu Asn Pro Gln Leu Ile Gln 
    370                 375                 380                 


Asn Met Leu Ser Ala Pro Tyr Met Arg Ser Met Met Gln Ser Leu Ser 
385                 390                 395                 400 


Gln Asn Pro Asp Leu Ala Ala Gln Met Met Leu Asn Ser Pro Leu Phe 
                405                 410                 415     


Thr Ala Asn Pro Gln Leu Gln Glu Gln Met Arg Pro Gln Leu Pro Ala 
            420                 425                 430         


Phe Leu Gln Gln Met Gln Asn Pro Asp Thr Leu Ser Ala Met Ser Asn 
        435                 440                 445             


Pro Arg Ala Met Gln Ala Leu Met Gln Ile Gln Gln Gly Leu Gln Thr 
    450                 455                 460                 


Leu Ala Thr Glu Ala Pro Gly Leu Ile Pro Ser Phe Thr Pro Gly Val 
465                 470                 475                 480 


Gly Val Gly Val Leu Gly Thr Ala Ile Gly Pro Val Gly Pro Val Thr 
                485                 490                 495     


Pro Ile Gly Pro Ile Gly Pro Ile Val Pro Phe Thr Pro Ile Gly Pro 
            500                 505                 510         


Ile Gly Pro Ile Gly Pro Thr Gly Pro Ala Ala Pro Pro Gly Ser Thr 
        515                 520                 525             


Gly Ser Gly Gly Pro Thr Gly Pro Thr Val Ser Ser Ala Ala Pro Ser 
    530                 535                 540                 


Glu Thr Thr Ser Pro Thr Ser Glu Ser Gly Pro Asn Gln Gln Phe Ile 
545                 550                 555                 560 


Gln Gln Met Val Gln Ala Leu Ala Gly Ala Asn Ala Pro Gln Leu Pro 
                565                 570                 575     


Asn Pro Glu Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Asn Ala Met 
            580                 585                 590         


Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly 
        595                 600                 605             


Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
    610                 615                 620                 


<210>  981
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  981

Met Ala Glu Gly Gly Gly Pro Glu Pro Gly Glu Gln Glu Arg Arg Ser 
1               5                   10                  15      


Ser Gly Pro Arg Pro Pro Ser Ala Arg Asp Leu Gln Leu Ala Leu Ala 
            20                  25                  30          


Glu Leu Tyr Glu Asp Glu Val Lys Cys Lys Ser Ser Lys Ser Asn Arg 
        35                  40                  45              


Pro Lys Ala Thr Val Phe Lys Ser Pro Arg Thr Pro Pro Gln Arg Phe 
    50                  55                  60                  


Tyr Ser Ser Glu His Glu Tyr Ser Gly Leu Asn Ile Val Arg Pro Ser 
65                  70                  75                  80  


Thr Gly Lys Ile Val Asn Glu Leu Phe Lys Glu Ala Arg Glu His Gly 
                85                  90                  95      


Ala Val Pro Leu Asn Glu Ala Thr Arg Ala Ser Gly Asp Asp Lys Ser 
            100                 105                 110         


Lys Ser Phe Thr Gly Gly Gly Tyr Arg Leu Gly Ser Ser Phe Cys Lys 
        115                 120                 125             


Arg Ser Glu Tyr Ile Tyr Gly Glu Asn Gln Leu Gln Asp Val Gln Ile 
    130                 135                 140                 


Leu Leu Lys Leu Trp Ser Asn Gly Phe Ser Leu Asp Asp Gly Glu Leu 
145                 150                 155                 160 


Arg Pro Tyr Asn Glu Pro Thr Asn Ala Gln Phe Leu Glu Ser Val Lys 
                165                 170                 175     


Arg Gly Glu Ile Pro Leu Glu Leu Gln Arg Leu Val His Gly Gly Gln 
            180                 185                 190         


Val Asn Leu Asp Met Glu Asp His Gln Asp Gln Glu Tyr Ile Lys Pro 
        195                 200                 205             


Arg Leu Arg Phe Lys Ala Phe Ser Gly Glu Gly Gln Lys Leu Gly Ser 
    210                 215                 220                 


Leu Thr Pro Glu Ile Val Ser Thr Pro Ser Ser Pro Glu Glu Glu Asp 
225                 230                 235                 240 


Lys Ser Ile Leu Asn Ala Val Val Leu Ile Asp Asp Ser Val Pro Thr 
                245                 250                 255     


Thr Lys Ile Gln Ile Arg Leu Ala Asp Gly Ser Arg Leu Ile Gln Arg 
            260                 265                 270         


Phe Asn Ser Thr His Arg Ile Leu Asp Val Arg Asn Phe Ile Val Gln 
        275                 280                 285             


Ser Arg Pro Glu Phe Ala Ala Leu Asp Phe Ile Leu Val Thr Ser Phe 
    290                 295                 300                 


Pro Asn Lys Glu Leu Thr Asp Glu Ser Leu Thr Leu Leu Glu Ala Asp 
305                 310                 315                 320 


Ile Leu Asn Thr Val Leu Leu Gln Gln Leu Lys 
                325                 330     


<210>  982
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  982

Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210>  983
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  983

Met Ala Glu Gly Gly Ala Ala Asp Leu Asp Thr Gln Arg Ser Asp Ile 
1               5                   10                  15      


Ala Thr Leu Leu Lys Thr Ser Leu Arg Lys Gly Asp Thr Trp Tyr Leu 
            20                  25                  30          


Val Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr Val Gly Phe Asp 
        35                  40                  45              


Ser Trp Asp Lys Tyr Gln Met Gly Asp Gln Asn Val Tyr Pro Gly Pro 
    50                  55                  60                  


Ile Asp Asn Ser Gly Leu Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys 
65                  70                  75                  80  


Glu His Leu Ile Asp Glu Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly 
                85                  90                  95      


Trp Asn Lys Leu Val Ser Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro 
            100                 105                 110         


Ile Ala Arg Lys Val Val Glu Gln Gly Met Phe Val Lys His Cys Lys 
        115                 120                 125             


Val Glu Val Tyr Leu Thr Glu Leu Lys Leu Cys Glu Asn Gly Asn Met 
    130                 135                 140                 


Asn Asn Val Val Thr Arg Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr 
145                 150                 155                 160 


Ile Glu Lys Glu Ile Arg Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu 
                165                 170                 175     


Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn 
            180                 185                 190         


Lys Pro Asp Ser Thr Ile Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val 
        195                 200                 205             


Leu Val Ile Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro 
    210                 215                 220                 


Ser Thr Pro Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr 
225                 230                 235                 240 


Ala Tyr Lys Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln 
                245                 250                 255     


Pro Gly Leu Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
            260                 265                 270         


Ser Ala Ile Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe 
        275                 280                 285             


Leu Asn Asp Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly 
    290                 295                 300                 


Met Arg Gly Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met 
305                 310                 315                 320 


Trp Ser Gly Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln 
                325                 330                 335     


Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys 
            340                 345                 350         


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
        355                 360                 365             


Arg Ile Arg Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg 
    370                 375                 380                 


Pro Asp Lys Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg 
385                 390                 395                 400 


Asn Asp Ser Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr 
                405                 410                 415     


Leu Val Cys Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe 
            420                 425                 430         


Cys Tyr Leu Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu 
        435                 440                 445             


Val Tyr Leu Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys 
    450                 455                 460                 


Val Val Val Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu 
465                 470                 475                 480 


Ser Ala Leu Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile 
                485                 490                 495     


Tyr Asn His Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser 
            500                 505                 510         


Ser Ile Met Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn 
        515                 520                 525             


Arg Thr Glu Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu 
    530                 535                 540                 


Lys Phe Arg His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe 
545                 550                 555                 560 


Gly Gln Pro Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys 
                565                 570                 575     


Leu Tyr Asn Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser 
            580                 585                 590         


Thr Glu Thr Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln 
        595                 600                 605             


Asn Ile Asn Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro 
    610                 615                 620                 


Ser Glu Met Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln 
625                 630                 635                 640 


Glu Leu Pro Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly 
                645                 650                 655     


Gly Asp Asn Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys 
            660                 665                 670         


Gly Gln Leu Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn 
        675                 680                 685             


Asn Leu Gly Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His 
    690                 695                 700                 


Ile Arg Phe Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu 
705                 710                 715                 720 


Ala Leu Asp Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn 
                725                 730                 735     


Ala Ala Glu Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro 
            740                 745                 750         


Lys Lys Pro Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr 
        755                 760                 765             


Lys Glu Lys Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys 
    770                 775                 780                 


Glu His Gln Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro 
785                 790                 795                 800 


Val Leu Val Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg 
                805                 810                 815     


Asp Lys Leu Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met 
            820                 825                 830         


Ser Glu Phe Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu 
        835                 840                 845             


Ile Ala Val Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr 
    850                 855                 860                 


Ala Phe Ala Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp 
865                 870                 875                 880 


Ser Ser Val Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala 
                885                 890                 895     


Tyr Val Leu Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe 
            900                 905                 910         


Phe Pro Leu Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile 
        915                 920                 925             


Pro Leu Glu Ser Asp Glu Asp Ser Asn Asp Asn Asp Asn Asp Ile Glu 
    930                 935                 940                 


Asn Glu Asn Cys Met His Thr Asn 
945                 950         


<210>  984
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  984

Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210>  985
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  985

Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln 
1               5                   10                  15      


Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala 
            20                  25                  30          


Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr 
        35                  40                  45              


Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu 
    50                  55                  60                  


Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser 
65                  70                  75                  80  


Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val 
                85                  90                  95      


Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu 
            100                 105                 110         


Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val 
        115                 120                 125             


Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu 
    130                 135                 140                 


Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp 
145                 150                 155                 160 


Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro 
                165                 170                 175     


Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr 
            180                 185                 190         


Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr 
        195                 200                 205             


Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp 
    210                 215                 220                 


Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn 
225                 230                 235                 240 


Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser 
                245                 250                 255     


Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His 
            260                 265                 270         


Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn 
        275                 280                 285             


Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu 
    290                 295                 300                 


Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu 
305                 310                 315                 320 


Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu 
                325                 330                 335     


Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala 
            340                 345                 350         


Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala 
        355                 360                 365             


His Val Ala Pro Arg Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro 
    370                 375                 380                 


Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
385                 390                 395                 400 


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro 
                405                 410                 415     


Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala 
            420                 425                 430         


Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val 
        435                 440                 445             


Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys 
    450                 455                 460                 


Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro 
465                 470                 475                 480 


Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala 
                485                 490                 495     


Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met 
            500                 505                 510         


Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile 
        515                 520                 525             


Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His 
    530                 535                 540                 


Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp 
545                 550                 555                 560 


Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu 
                565                 570                 575     


Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser 
            580                 585                 590         


Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser 
        595                 600                 605             


Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys 
    610                 615                 620                 


Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly 
625                 630                 635                 640 


Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys 
                645                 650                 655     


Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu 
            660                 665                 670         


Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp 
        675                 680                 685             


Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys 
    690                 695                 700                 


Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile 
705                 710                 715                 720 


Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser 
                725                 730                 735     


Thr Leu Ala Met Asp Trp Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp 
            740                 745                 750         


Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro 
        755                 760                 765             


Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu 
    770                 775                 780                 


Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro 
785                 790                 795                 800 


Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser 
                805                 810                 815     


Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg 
            820                 825                 830         


Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly 
        835                 840                 845             


Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val 
    850                 855                 860                 


Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly 
865                 870                 875                 880 


His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr 
                885                 890                 895     


Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr 
            900                 905                 910         


Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr 
        915                 920                 925             


Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg 
    930                 935                 940                 


Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met 
945                 950                 955                 960 


Asp Thr Asn 
            


<210>  986
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  986

Met Thr Ala Asn Arg Leu Ala Glu Ser Leu Leu Ala Leu Ser Gln Gln 
1               5                   10                  15      


Glu Glu Leu Ala Asp Leu Pro Lys Asp Tyr Leu Leu Ser Glu Ser Glu 
            20                  25                  30          


Asp Glu Gly Asp Asn Asp Gly Glu Arg Lys His Gln Lys Leu Leu Glu 
        35                  40                  45              


Ala Ile Ser Ser Leu Asp Gly Lys Asn Arg Arg Lys Leu Ala Glu Arg 
    50                  55                  60                  


Ser Glu Ala Ser Leu Lys Val Ser Glu Phe Asn Val Ser Ser Glu Gly 
65                  70                  75                  80  


Ser Gly Glu Lys Leu Val Leu Ala Asp Leu Leu Glu Pro Val Lys Thr 
                85                  90                  95      


Ser Ser Ser Leu Ala Thr Val Lys Lys Gln Leu Ser Arg Val Lys Ser 
            100                 105                 110         


Lys Lys Thr Val Glu Leu Pro Leu Asn Lys Glu Glu Ile Glu Arg Ile 
        115                 120                 125             


His Arg Glu Val Ala Phe Asn Lys Thr Ala Gln Val Leu Ser Lys Trp 
    130                 135                 140                 


Asp Pro Val Val Leu Lys Asn Arg Gln Ala Glu Gln Leu Val Phe Pro 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Pro Ala Ile Ala Pro Ile Glu His Val Leu Ser 
                165                 170                 175     


Gly Trp Lys Ala Arg Thr Pro Leu Glu Gln Glu Ile Phe Asn Leu Leu 
            180                 185                 190         


His Lys Asn Lys Gln Pro Val Thr Asp Pro Leu Leu Thr Pro Val Glu 
        195                 200                 205             


Lys Ala Ser Leu Arg Ala Met Ser Leu Glu Glu Ala Lys Met Arg Arg 
    210                 215                 220                 


Ala Glu Leu Gln Arg Ala Arg Ala Leu Gln Ser Tyr Tyr Glu Ala Lys 
225                 230                 235                 240 


Ala Arg Arg Glu Lys Lys Ile Lys Ser Lys Lys Tyr His Lys Val Val 
                245                 250                 255     


Lys Lys Gly Lys Ala Lys Lys Ala Leu Lys Glu Phe Glu Gln Leu Arg 
            260                 265                 270         


Lys Val Asn Pro Ala Ala Ala Leu Glu Glu Leu Glu Lys Ile Glu Lys 
        275                 280                 285             


Ala Arg Met Met Glu Arg Met Ser Leu Lys His Gln Asn Ser Gly Lys 
    290                 295                 300                 


Trp Ala Lys Ser Lys Ala Ile Met Ala Lys Tyr Asp Leu Glu Ala Arg 
305                 310                 315                 320 


Gln Ala Met Gln Glu Gln Leu Ser Lys Asn Lys Glu Leu Thr Gln Lys 
                325                 330                 335     


Leu Gln Val Ala Ser Glu Ser Glu Glu Glu Glu Gly Gly Thr Glu Asp 
            340                 345                 350         


Val Glu Glu Leu Leu Val Pro Asp Val Val Asn Glu Val Gln Met Asn 
        355                 360                 365             


Ala Asp Gly Pro Asn Pro Trp Met Leu Arg Ser Cys Thr Ser Asp Thr 
    370                 375                 380                 


Lys Glu Ala Ala Thr Gln Glu Asp Pro Glu Gln Leu Pro Glu Leu Glu 
385                 390                 395                 400 


Ala His Gly Val Ser Glu Ser Glu Gly Glu Glu Arg Pro Val Ala Glu 
                405                 410                 415     


Glu Glu Ile Leu Leu Arg Glu Phe Glu Glu Arg Arg Ser Leu Arg Lys 
            420                 425                 430         


Arg Ser Glu Leu Ser Gln Asp Ala Glu Pro Ala Gly Ser Gln Glu Thr 
        435                 440                 445             


Lys Asp Ser Gly Ser Gln Glu Val Leu Ser Glu Leu Arg Val Leu Ser 
    450                 455                 460                 


Gln Lys Leu Lys Glu Asn His Gln Ser Arg Lys Gln Lys Ala Ser Ser 
465                 470                 475                 480 


Glu Gly Thr Ile Pro Gln Val Gln Arg Glu Glu Pro Ala Pro Glu Glu 
                485                 490                 495     


Glu Glu Pro Leu Leu Leu Gln Arg Pro Glu Arg Val Gln Thr Leu Glu 
            500                 505                 510         


Glu Leu Glu Glu Leu Gly Lys Glu Glu Cys Phe Gln Asn Lys Glu Leu 
        515                 520                 525             


Pro Arg Pro Val Leu Glu Gly Gln Gln Ser Glu Arg Thr Pro Asn Asn 
    530                 535                 540                 


Arg Pro Asp Ala Pro Lys Glu Lys Lys Lys Lys Glu Gln Met Ile Asp 
545                 550                 555                 560 


Leu Gln Asn Leu Leu Thr Thr Gln Ser Pro Ser Val Lys Ser Leu Ala 
                565                 570                 575     


Val Pro Thr Ile Glu Glu Leu Glu Asp Glu Glu Glu Arg Asn His Arg 
            580                 585                 590         


Gln Met Ile Lys Glu Ala Phe Ala Gly Asp Asp Val Ile Arg Asp Phe 
        595                 600                 605             


Leu Lys Glu Lys Arg Glu Ala Val Glu Ala Ser Lys Pro Lys Asp Val 
    610                 615                 620                 


Asp Leu Thr Leu Pro Gly Trp Gly Glu Trp Gly Gly Val Gly Leu Lys 
625                 630                 635                 640 


Pro Ser Ala Lys Lys Arg Arg Arg Phe Leu Ile Lys Ala Pro Glu Gly 
                645                 650                 655     


Pro Pro Arg Lys Asp Lys Asn Leu Pro Asn Val Ile Ile Asn Glu Lys 
            660                 665                 670         


Arg Asn Ile His Ala Ala Ala His Gln Val Arg Val Leu Pro Tyr Pro 
        675                 680                 685             


Phe Thr His His Trp Gln Phe Glu Arg Thr Ile Gln Thr Pro Ile Gly 
    690                 695                 700                 


Ser Thr Trp Asn Thr Gln Arg Ala Phe Gln Lys Leu Thr Thr Pro Lys 
705                 710                 715                 720 


Val Val Thr Lys Pro Gly His Ile Ile Asn Pro Ile Lys Ala Glu Asp 
                725                 730                 735     


Val Gly Tyr Arg Ser Ser Ser Arg Ser Asp Leu Ser Val Ile Gln Arg 
            740                 745                 750         


Asn Pro Lys Arg Ile Thr Thr Arg His Lys Lys Gln Leu Lys Lys Cys 
        755                 760                 765             


Ser Val Asp 
    770     


<210>  987
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  987

Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln 
1               5                   10                  15      


Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
            20                  25                  30          


Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
        35                  40                  45              


Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
    50                  55                  60                  


Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala 
65                  70                  75                  80  


Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp 
                85                  90                  95      


Val Val Ser Ser 
            100 


<210>  988
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  988

Met Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Cys Lys Val 
1               5                   10                  15      


Leu Pro Thr Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp 
            20                  25                  30          


Leu Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Arg Ala His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Ala Cys Cys Glu Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Glu Thr Leu 
            100                 105                 110         


Ser Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu 
    130                 135                 140                 


Pro Asp Leu Ile Asp Glu Thr Leu Val Glu Asp Glu Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu 
                165                 170                 175     


Met Lys Ala Glu Glu Ala His Gln Pro Lys Cys Pro Glu Asn Asp Ile 
            180                 185                 190         


Arg Ser Cys Cys Leu Ala Glu Ile Lys Gln Thr Glu Glu Lys Tyr Thr 
        195                 200                 205             


Glu Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg 
    210                 215                 220                 


Phe Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Glu 
225                 230                 235                 240 


Leu Val Lys Leu His Arg Asn Leu Met Gln Glu Ile His Asp Ser Ile 
                245                 250                 255     


Val Asn Lys Asn Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys 
            260                 265                 270         


Glu Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala 
        275                 280                 285             


Ile Ser Ser Leu Asp Tyr Ile Ser Lys Thr Lys Glu Asp Val Lys Leu 
    290                 295                 300                 


Lys Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu 
305                 310                 315                 320 


Arg Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu 
                325                 330                 335     


Leu Leu Gln Glu Leu Val Lys His Thr Thr Asp Pro Thr Glu Lys Ala 
            340                 345                 350         


Asn Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val 
        355                 360                 365             


Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe 
    370                 375                 380                 


Gln Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg 
385                 390                 395                 400 


Pro Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr 
                405                 410                 415     


Lys Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys 
            420                 425                 430         


Lys Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln 
        435                 440                 445             


Gln Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys 
    450                 455                 460                 


Trp Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu 
465                 470                 475                 480 


Glu Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln 
                485                 490                 495     


Phe Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn 
            500                 505                 510         


Phe His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Lys 
        515                 520                 525             


Val Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys 
    530                 535                 540                 


Phe Lys Cys Gly Ala Arg Ala His Lys Glu Cys Leu Gly Arg Val Asp 
545                 550                 555                 560 


Asn Cys Gly Arg Val Asn Ser Gly Glu Gln Gly Thr Leu Lys Leu Pro 
                565                 570                 575     


Glu Lys Arg Thr Asn Gly Leu Arg Arg Thr Pro Lys Gln Val Asp Pro 
            580                 585                 590         


Gly Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Ser Gly Thr Pro Pro 
        595                 600                 605             


Pro Ala Leu His Glu Gly Pro Pro Leu Gln Leu Gln Ala Gly Asp Thr 
    610                 615                 620                 


Val Glu Leu Leu Lys Gly Asp Ala His Ser Leu Phe Trp Gln Gly Arg 
625                 630                 635                 640 


Asn Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys 
                645                 650                 655     


Pro Cys Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp 
            660                 665                 670         


Tyr Ala Gly Ala Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn 
        675                 680                 685             


Arg Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly 
    690                 695                 700                 


Glu Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys 
705                 710                 715                 720 


Ile Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe 
                725                 730                 735     


Lys Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys 
            740                 745                 750         


Glu Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu 
        755                 760                 765             


Pro Glu His Ser Ala Gly Gln Arg Gly Asn Arg Ala Gly Asn Ser Leu 
    770                 775                 780                 


Leu Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys 
785                 790                 795                 800 


Ala Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Val Val Lys 
                805                 810                 815     


Ile Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn 
            820                 825                 830         


Gly Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu 
        835                 840                 845         


<210>  989
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  989

Met Glu Ala Asn Trp Thr Ala Phe Leu Phe Gln Ala His Glu Ala Ser 
1               5                   10                  15      


His His Gln Gln Gln Ala Ala Gln Asn Ser Leu Leu Pro Leu Leu Ser 
            20                  25                  30          


Ser Ala Val Glu Pro Pro Asp Gln Lys Pro Leu Leu Pro Ile Pro Ile 
        35                  40                  45              


Thr Gln Lys Pro Gln Gly Ala Pro Glu Thr Leu Lys Asp Ala Ile Gly 
    50                  55                  60                  


Ile Lys Lys Glu Lys Pro Lys Thr Ser Phe Val Cys Thr Tyr Cys Ser 
65                  70                  75                  80  


Lys Ala Phe Arg Asp Ser Tyr His Leu Arg Arg His Glu Ser Cys His 
                85                  90                  95      


Thr Gly Ile Lys Leu Val Ser Arg Pro Lys Lys Thr Pro Thr Thr Val 
            100                 105                 110         


Val Pro Leu Ile Ser Thr Ile Ala Gly Asp Ser Ser Arg Thr Ser Leu 
        115                 120                 125             


Val Ser Thr Ile Ala Gly Ile Leu Ser Thr Val Thr Thr Ser Ser Ser 
    130                 135                 140                 


Gly Thr Asn Pro Ser Ser Ser Ala Ser Thr Thr Ala Met Pro Val Thr 
145                 150                 155                 160 


Gln Ser Val Lys Lys Pro Ser Lys Pro Val Lys Lys Asn His Ala Cys 
                165                 170                 175     


Glu Met Cys Gly Lys Ala Phe Arg Asp Val Tyr His Leu Asn Arg His 
            180                 185                 190         


Lys Leu Ser His Ser Asp Glu Lys Pro Phe Glu Cys Pro Ile Cys Asn 
        195                 200                 205             


Gln Arg Phe Lys Arg Lys Asp Arg Met Thr Tyr His Val Arg Ser His 
    210                 215                 220                 


Glu Gly Gly Ile Thr Lys Pro Tyr Thr Cys Ser Val Cys Gly Lys Gly 
225                 230                 235                 240 


Phe Ser Arg Pro Asp His Leu Ser Cys His Val Lys His Val His Ser 
                245                 250                 255     


Thr Glu Arg Pro Phe Lys Cys Gln Thr Cys Thr Ala Ala Phe Ala Thr 
            260                 265                 270         


Lys Asp Arg Leu Arg Thr His Met Val Arg His Glu Gly Lys Val Ser 
        275                 280                 285             


Cys Asn Ile Cys Gly Lys Leu Leu Ser Ala Ala Tyr Ile Thr Ser His 
    290                 295                 300                 


Leu Lys Thr His Gly Gln Ser Gln Ser Ile Asn Cys Asn Thr Cys Lys 
305                 310                 315                 320 


Gln Gly Ile Ser Lys Thr Cys Met Ser Glu Glu Thr Ser Asn Gln Lys 
                325                 330                 335     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            340                 345                 350         


Gln Gln His Val Thr Ser Trp Pro Gly Lys Gln Val Glu Thr Leu Arg 
        355                 360                 365             


Leu Trp Glu Glu Ala Val Lys Ala Arg Lys Lys Glu Ala Ala Asn Leu 
    370                 375                 380                 


Cys Gln Thr Ser Thr Ala Ala Thr Thr Pro Val Thr Leu Thr Thr Pro 
385                 390                 395                 400 


Phe Ser Ile Thr Ser Ser Val Ser Ser Gly Thr Met Ser Asn Pro Val 
                405                 410                 415     


Thr Val Ala Ala Ala Met Ser Met Arg Ser Pro Val Asn Val Ser Ser 
            420                 425                 430         


Ala Val Asn Ile Thr Ser Pro Met Asn Ile Gly His Pro Val Thr Ile 
        435                 440                 445             


Thr Ser Pro Leu Ser Met Thr Ser Pro Leu Thr Leu Thr Thr Pro Val 
    450                 455                 460                 


Asn Leu Pro Thr Pro Val Thr Ala Pro Val Asn Ile Ala His Pro Val 
465                 470                 475                 480 


Thr Ile Thr Ser Pro Met Asn Leu Pro Thr Pro Met Thr Leu Ala Ala 
                485                 490                 495     


Pro Leu Asn Ile Ala Met Arg Pro Val Glu Ser Met Pro Phe Leu Pro 
            500                 505                 510         


Gln Ala Leu Pro Thr Ser Pro Pro Trp 
        515                 520     


<210>  990
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  990

Met Glu Asn Glu Pro Asp His Glu Asn Val Glu Gln Ser Leu Cys Ala 
1               5                   10                  15      


Lys Thr Ser Glu Glu Glu Leu Asn Lys Ser Phe Asn Leu Glu Ala Ser 
            20                  25                  30          


Leu Ser Lys Phe Ser Tyr Ile Asp Met Asp Lys Glu Leu Glu Phe Lys 
        35                  40                  45              


Asn Asp Leu Ile Asp Asp Lys Glu Phe Asp Ile Pro Gln Val Asp Thr 
    50                  55                  60                  


Pro Pro Thr Leu Glu Ser Ile Leu Asn Glu Thr Asp Asp Glu Asp Glu 
65                  70                  75                  80  


Ser Phe Ile Leu Glu Asp Pro Thr Leu Leu Asn Ile Asp Thr Ile Asp 
                85                  90                  95      


Ser His Ser Tyr Asp Thr Ser Ser Val Ala Ser Ser Asp Ser Gly Asp 
            100                 105                 110         


Arg Thr Asn Leu Lys Arg Lys Lys Lys Leu Pro Asp Ser Phe Ser Leu 
        115                 120                 125             


His Gly Ser Val Met Arg His Ser Leu Leu Lys Gly Ile Ser Ala Gln 
    130                 135                 140                 


Ile Val Ser Ala Ala Asp Lys Val Asp Ala Gly Leu Pro Thr Ala Ile 
145                 150                 155                 160 


Ala Val Ser Ser Leu Ile Ala Val Gly Thr Ser His Gly Leu Ala Leu 
                165                 170                 175     


Ile Phe Asp Gln Asn Gln Ala Leu Arg Leu Cys Leu Gly Ser Thr Ser 
            180                 185                 190         


Val Gly Gly Gln Tyr Gly Ala Ile Ser Ala Leu Ser Ile Asn Asn Asp 
        195                 200                 205             


Cys Ser Arg Leu Leu Cys Gly Phe Ala Lys Gly Gln Ile Thr Met Trp 
    210                 215                 220                 


Asp Leu Ala Ser Gly Lys Leu Leu Arg Ser Ile Thr Asp Ala His Pro 
225                 230                 235                 240 


Pro Gly Thr Ala Ile Leu His Ile Lys Phe Thr Asp Asp Pro Thr Leu 
                245                 250                 255     


Ala Ile Cys Asn Asp Ser Gly Gly Ser Val Phe Glu Leu Thr Phe Lys 
            260                 265                 270         


Arg Val Met Gly Val Arg Thr Cys Glu Ser Arg Cys Leu Phe Ser Gly 
        275                 280                 285             


Ser Lys Gly Glu Val Cys Cys Ile Glu Pro Leu His Ser Lys Pro Glu 
    290                 295                 300                 


Leu Lys Asp His Pro Ile Thr Gln Phe Ser Leu Leu Ala Met Ala Ser 
305                 310                 315                 320 


Leu Thr Lys Ile Leu Val Ile Gly Leu Lys Pro Ser Leu Lys Val Trp 
                325                 330                 335     


Met Thr Phe Pro Tyr Gly Arg Met Asp Pro Ser Ser Val Pro Leu Leu 
            340                 345                 350         


Ala Trp His Phe Val Ala Val Gln Asn Tyr Val Asn Pro Met Leu Ala 
        355                 360                 365             


Phe Cys Arg Gly Asp Val Val His Phe Leu Leu Val Lys Arg Asp Glu 
    370                 375                 380                 


Ser Gly Ala Ile His Val Thr Lys Gln Lys His Leu His Leu Tyr Tyr 
385                 390                 395                 400 


Asp Leu Ile Asn Phe Thr Trp Ile Asn Ser Arg Thr Val Val Leu Leu 
                405                 410                 415     


Asp Ser Val Glu Lys Leu His Val Ile Asp Arg Gln Thr Gln Glu Glu 
            420                 425                 430         


Leu Glu Thr Val Glu Ile Ser Glu Val Gln Leu Val Tyr Asn Ser Ser 
        435                 440                 445             


His Phe Lys Ser Leu Ala Thr Gly Gly Asn Val Ser Gln Ala Leu Ala 
    450                 455                 460                 


Leu Val Gly Glu Lys Ala Cys Tyr Gln Ser Ile Ser Ser Tyr Gly Gly 
465                 470                 475                 480 


Gln Ile Phe Tyr Leu Gly Thr Lys Ser Val Tyr Val Met Met Leu Arg 
                485                 490                 495     


Ser Trp Arg Glu Arg Val Asp His Leu Leu Lys Gln Asp Cys Leu Thr 
            500                 505                 510         


Glu Ala Leu Ala Leu Ala Trp Ser Phe His Glu Gly Lys Ala Lys Ala 
        515                 520                 525             


Val Val Gly Leu Ser Gly Asp Ala Ser Lys Arg Lys Ala Ile Val Ala 
    530                 535                 540                 


Asp Arg Met Val Glu Ile Leu Phe His Tyr Ala Asp Arg Ala Leu Lys 
545                 550                 555                 560 


Lys Cys Pro Asp Gln Gly Lys Ile Gln Val Met Glu Gln His Phe Gln 
                565                 570                 575     


Asp Met Val Pro Val Ile Val Asp Tyr Cys Leu Leu Leu Gln Arg Lys 
            580                 585                 590         


Asp Leu Leu Phe Ser Gln Met Tyr Asp Lys Leu Ser Glu Asn Ser Val 
        595                 600                 605             


Ala Lys Gly Val Phe Leu Glu Cys Leu Glu Pro Tyr Ile Leu Ser Asp 
    610                 615                 620                 


Lys Leu Val Gly Ile Thr Pro Gln Val Met Lys Asp Leu Ile Val His 
625                 630                 635                 640 


Phe Gln Asp Lys Lys Leu Met Glu Asn Val Glu Ala Leu Ile Val His 
                645                 650                 655     


Met Asp Ile Thr Ser Leu Asp Ile Gln Gln Val Val Leu Met Cys Trp 
            660                 665                 670         


Glu Asn Arg Leu Tyr Asp Ala Met Ile Tyr Val Tyr Asn Arg Gly Met 
        675                 680                 685             


Asn Glu Phe Ile Ser Pro Met Glu Lys Leu Phe Arg Val Ile Ala Pro 
    690                 695                 700                 


Pro Leu Asn Ala Gly Lys Thr Leu Thr Asp Glu Gln Val Val Met Gly 
705                 710                 715                 720 


Asn Lys Leu Leu Val Tyr Ile Ser Cys Cys Leu Ala Gly Arg Ala Tyr 
                725                 730                 735     


Pro Leu Gly Asp Ile Pro Glu Asp Leu Val Pro Leu Val Lys Asn Gln 
            740                 745                 750         


Val Phe Glu Phe Leu Ile Arg Leu His Ser Ala Glu Ala Ser Pro Glu 
        755                 760                 765             


Glu Glu Ile Tyr Pro Tyr Ile Arg Thr Leu Leu His Phe Asp Thr Arg 
    770                 775                 780                 


Glu Phe Leu Asn Val Leu Ala Leu Thr Phe Glu Asp Phe Lys Asn Asp 
785                 790                 795                 800 


Lys Gln Ala Val Glu Tyr Gln Gln Arg Ile Val Asp Ile Leu Leu Lys 
                805                 810                 815     


Val Met Val Glu Asn Ser Asp Phe Thr Pro Ser Gln Val Gly Cys Leu 
            820                 825                 830         


Phe Thr Phe Leu Ala Arg Gln Leu Ala Lys Pro Asp Asn Thr Leu Phe 
        835                 840                 845             


Val Asn Arg Thr Leu Phe Asp Gln Val Leu Glu Phe Leu Cys Ser Pro 
    850                 855                 860                 


Asp Asp Asp Ser Arg His Ser Glu Arg Gln Gln Val Leu Leu Glu Leu 
865                 870                 875                 880 


Leu Gln Ala Gly Gly Ile Val Gln Phe Glu Glu Ser Arg Leu Ile Arg 
                885                 890                 895     


Met Ala Glu Lys Ala Glu Phe Tyr Gln Ile Cys Glu Phe Met Tyr Glu 
            900                 905                 910         


Arg Glu His Gln Tyr Asp Lys Ile Ile Asp Cys Tyr Leu Arg Asp Pro 
        915                 920                 925             


Leu Arg Glu Glu Glu Val Phe Asn Tyr Ile His Asn Ile Leu Ser Ile 
    930                 935                 940                 


Pro Gly His Ser Ala Glu Glu Lys Gln Ser Val Trp Gln Lys Ala Met 
945                 950                 955                 960 


Asp His Ile Glu Glu Leu Val Ser Leu Lys Pro Cys Lys Ala Ala Glu 
                965                 970                 975     


Leu Val Ala Thr His Phe Ser Gly His Ile Glu Thr Val Ile Lys Lys 
            980                 985                 990         


Leu Gln Asn Gln Val Leu Leu Phe  Lys Phe Leu Arg Ser  Leu Leu Asp 
        995                 1000                 1005             


Pro Arg  Glu Gly Ile His Val  Asn Gln Glu Leu Leu  Gln Ile Ser 
    1010                 1015                 1020             


Pro Cys  Ile Thr Glu Gln Phe  Ile Glu Leu Leu Cys  Gln Phe Asn 
    1025                 1030                 1035             


Pro Thr  Gln Val Ile Glu Thr  Leu Gln Val Leu Glu  Cys Tyr Arg 
    1040                 1045                 1050             


Leu Glu  Glu Thr Ile Gln Ile  Thr Gln Lys Tyr Gln  Leu His Glu 
    1055                 1060                 1065             


Val Thr  Ala Tyr Leu Leu Glu  Lys Lys Gly Asp Ile  His Gly Ala 
    1070                 1075                 1080             


Phe Leu  Ile Met Leu Glu Arg  Leu Gln Ser Lys Leu  Gln Glu Val 
    1085                 1090                 1095             


Thr His  Gln Gly Glu Asn Thr  Lys Glu Asp Pro Ser  Leu Lys Asp 
    1100                 1105                 1110             


Val Glu  Asp Thr Met Val Glu  Thr Ile Ala Leu Cys  Gln Arg Asn 
    1115                 1120                 1125             


Ser His  Asn Leu Asn Gln Gln  Gln Arg Glu Ala Leu  Trp Phe Pro 
    1130                 1135                 1140             


Leu Leu  Glu Ala Met Met Ala  Pro Gln Lys Leu Ser  Ser Ser Ala 
    1145                 1150                 1155             


Ile Pro  His Leu His Ser Glu  Ala Leu Lys Ser Leu  Thr Met Gln 
    1160                 1165                 1170             


Val Leu  Asn Ser Met Ala Ala  Phe Ile Ala Leu Pro  Ser Ile Leu 
    1175                 1180                 1185             


Gln Arg  Ile Leu Gln Asp Pro  Val Tyr Gly Lys Gly  Lys Leu Gly 
    1190                 1195                 1200             


Glu Ile  Gln Gly Leu Ile Leu  Gly Met Leu Asp Thr  Phe Asn Tyr 
    1205                 1210                 1215             


Glu Gln  Thr Leu Leu Glu Thr  Thr Thr Ser Leu Leu  Asn Gln Asp 
    1220                 1225                 1230             


Leu His  Trp Ser Leu Cys Asn  Leu Arg Ala Ser Val  Thr Arg Gly 
    1235                 1240                 1245             


Leu Asn  Pro Lys Gln Asp Tyr  Cys Ser Ile Cys Leu  Gln Gln Tyr 
    1250                 1255                 1260             


Lys Arg  Arg Gln Glu Met Ala  Asp Glu Ile Ile Val  Phe Ser Cys 
    1265                 1270                 1275             


Gly His  Leu Tyr His Ser Phe  Cys Leu Gln Asn Lys  Glu Cys Thr 
    1280                 1285                 1290             


Val Glu  Phe Glu Gly Gln Thr  Arg Trp Thr Cys Tyr  Lys Cys Ser 
    1295                 1300                 1305             


Ser Ser  Asn Lys Val Gly Lys  Leu Ser Glu Asn Ser  Ser Glu Ile 
    1310                 1315                 1320             


Lys Lys  Gly Arg Ile Thr Pro  Ser Gln Val Lys Met  Ser Pro Ser 
    1325                 1330                 1335             


Tyr His  Gln Ser Lys Gly Asp  Pro Thr Ala Lys Lys  Gly Thr Ser 
    1340                 1345                 1350             


Glu Pro  Val Leu Asp Pro Gln  Gln Ile Gln Ala Phe  Asp Gln Leu 
    1355                 1360                 1365             


Cys Arg  Leu Tyr Arg Gly Ser  Ser Arg Leu Ala Leu  Leu Thr Glu 
    1370                 1375                 1380             


Leu Ser  Gln Asn Arg Ser Ser  Glu Ser Tyr Arg Pro  Phe Ser Gly 
    1385                 1390                 1395             


Ser Gln  Ser Ala Pro Ala Phe  Asn Ser Ile Phe Gln  Asn Glu Asn 
    1400                 1405                 1410             


Phe Gln  Leu Gln Leu Ile Pro  Pro Pro Val Thr Glu  Asp 
    1415                 1420                 1425     


<210>  991
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  991

Met Pro Leu Val Thr Arg Asn Ile Glu Pro Arg His Leu Cys Arg Gln 
1               5                   10                  15      


Thr Leu Pro Ser Val Arg Ser Glu Leu Glu Cys Val Thr Asn Ile Thr 
            20                  25                  30          


Leu Ala Asn Val Ile Arg Gln Leu Gly Ser Leu Ser Lys Tyr Ala Glu 
        35                  40                  45              


Asp Ile Phe Gly Glu Leu Phe Thr Gln Ala Asn Thr Phe Ala Ser Arg 
    50                  55                  60                  


Val Ser Ser Leu Ala Glu Arg Val Asp Arg Leu Gln Val Lys Val Thr 
65                  70                  75                  80  


Gln Leu Asp Pro Lys Glu Glu Glu Val Ser Leu Gln Gly Ile Asn Thr 
                85                  90                  95      


Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Lys Leu Phe Asp 
            100                 105                 110         


Arg Asn Ser Leu Pro Val Pro Val Leu Glu Thr Tyr Asn Thr Cys Asp 
        115                 120                 125             


Thr Pro Pro Pro Leu Asn Asn Leu Thr Pro Tyr Arg Asp Asp Gly Lys 
    130                 135                 140                 


Glu Ala Leu Lys Phe Tyr Thr Asp Pro Ser Tyr Phe Phe Asp Leu Trp 
145                 150                 155                 160 


Lys Glu Lys Met Leu Gln Asp Thr Lys Asp Ile Met Lys Glu Lys Arg 
                165                 170                 175     


Lys His Arg Lys Glu Lys Lys Asp Asn Pro Asn Arg Gly Asn Val Asn 
            180                 185                 190         


Pro Arg Lys Ile Lys Thr Arg Lys Glu Glu Trp Glu Lys Met Lys Met 
        195                 200                 205             


Gly Gln Glu Phe Val Glu Ser Lys Glu Lys Leu Gly Thr Ser Gly Tyr 
    210                 215                 220                 


Pro Pro Thr Leu Val Tyr Gln Asn Gly Ser Ile Gly Cys Val Glu Asn 
225                 230                 235                 240 


Val Asp Ala Ser Ser Tyr Pro Pro Pro Pro Gln Ser Asp Ser Ala Ser 
                245                 250                 255     


Ser Pro Ser Pro Ser Phe Ser Glu Asp Asn Leu Pro Pro Pro Pro Ala 
            260                 265                 270         


Glu Phe Ser Tyr Pro Val Asp Asn Gln Arg Gly Ser Gly Leu Ala Gly 
        275                 280                 285             


Pro Lys Arg Ser Ser Val Val Ser Pro Ser His Pro Pro Pro Ala Pro 
    290                 295                 300                 


Pro Leu Gly Ser Pro Pro Gly Pro Lys Pro Gly Phe Ala Pro Pro Pro 
305                 310                 315                 320 


Ala Pro Pro Pro Pro Pro Pro Pro Met Ile Gly Ile Pro Pro Pro Pro 
                325                 330                 335     


Pro Pro Val Gly Phe Gly Ser Pro Gly Thr Pro Pro Pro Pro Ser Pro 
            340                 345                 350         


Pro Ser Phe Pro Pro His Pro Asp Phe Ala Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Pro Pro Ala Ala Asp Tyr Pro Thr Leu Pro Pro Pro Pro Leu Ser 
    370                 375                 380                 


Gln Pro Thr Gly Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Pro Pro Phe Thr Gly Ala Asp Gly Gln Pro Ala Ile 
                405                 410                 415     


Pro Pro Pro Leu Ser Asp Thr Thr Lys Pro Lys Ser Ser Leu Pro Ala 
            420                 425                 430         


Val Ser Asp Ala Arg Ser Asp Leu Leu Ser Ala Ile Arg Gln Gly Phe 
        435                 440                 445             


Gln Leu Arg Arg Val Glu Glu Gln Arg Glu Gln Glu Lys Arg Asp Val 
    450                 455                 460                 


Val Gly Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu 
465                 470                 475                 480 


Tyr Ser Asp Ser Glu Asp Asp Ser Ser Glu Phe Asp Glu Asp Asp Trp 
                485                 490                 495     


Ser Asp 
        


<210>  992
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  992

Met Ala Leu Asn Lys Asn His Ser Glu Gly Gly Gly Val Ile Val Asn 
1               5                   10                  15      


Asn Thr Glu Ser Ile Leu Met Ser Tyr Asp His Val Glu Leu Thr Phe 
            20                  25                  30          


Asn Asp Met Lys Asn Val Pro Glu Ala Phe Lys Gly Thr Lys Lys Gly 
        35                  40                  45              


Thr Val Tyr Leu Thr Pro Tyr Arg Val Ile Phe Leu Ser Lys Gly Lys 
    50                  55                  60                  


Asp Ala Met Gln Ser Phe Met Met Pro Phe Tyr Leu Met Lys Asp Cys 
65                  70                  75                  80  


Glu Ile Lys Gln Pro Val Phe Gly Ala Asn Tyr Ile Lys Gly Thr Val 
                85                  90                  95      


Lys Ala Glu Ala Gly Gly Gly Trp Glu Gly Ser Ala Ser Tyr Lys Leu 
            100                 105                 110         


Thr Phe Thr Ala Gly Gly Ala Ile Glu Phe Gly Gln Arg Met Leu Gln 
        115                 120                 125             


Val Ala Ser Gln Ala Ser Arg Gly Glu Val Pro Ser Gly Ala Tyr Gly 
    130                 135                 140                 


Tyr Ser Tyr Met Pro Ser Gly Ala Tyr Val Tyr Pro Pro Pro Val Ala 
145                 150                 155                 160 


Asn Gly Met Tyr Pro Cys Pro Pro Gly Tyr Pro Tyr Pro Pro Pro Pro 
                165                 170                 175     


Pro Glu Phe Tyr Pro Gly Pro Pro Met Met Asp Gly Ala Met Gly Tyr 
            180                 185                 190         


Val Gln Pro Pro Pro Pro Pro Tyr Pro Gly Pro Met Glu Pro Pro Val 
        195                 200                 205             


Ser Gly Pro Asp Val Pro Ser Thr Pro Ala Ala Glu Ala Lys Ala Ala 
    210                 215                 220                 


Glu Ala Ala Ala Ser Ala Tyr Tyr Asn Pro Gly Asn Pro His Asn Val 
225                 230                 235                 240 


Tyr Met Pro Thr Ser Gln Pro Pro Pro Pro Pro Tyr Tyr Pro Pro Glu 
                245                 250                 255     


Asp Lys Lys Thr Gln 
            260     


<210>  993
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  993

Met Pro Thr Glu Ser Ala Ser Cys Ser Thr Ala Arg Gln Thr Lys Gln 
1               5                   10                  15      


Lys Arg Lys Ser His Ser Leu Ser Ile Arg Arg Thr Asn Ser Ser Glu 
            20                  25                  30          


Gln Glu Arg Thr Gly Leu Pro Arg Asp Met Leu Glu Gly Gln Asp Ser 
        35                  40                  45              


Lys Leu Pro Ser Ser Val Arg Ser Thr Leu Leu Glu Leu Phe Gly Gln 
    50                  55                  60                  


Ile Glu Arg Glu Phe Glu Asn Leu Tyr Ile Glu Asn Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Ile Asp Thr Leu Asn Glu Arg Leu Ala Ala Glu Gly Gln Ala 
                85                  90                  95      


Ile Asp Gly Ala Glu Leu Ser Lys Gly Gln Leu Lys Thr Lys Ala Ser 
            100                 105                 110         


His Ser Thr Ser Gln Leu Ser Gln Lys Leu Lys Thr Thr Tyr Lys Ala 
        115                 120                 125             


Ser Thr Ser Lys Ile Val Ser Ser Phe Lys Thr Thr Thr Ser Arg Ala 
    130                 135                 140                 


Ala Cys Gln Leu Val Lys Glu Tyr Ile Gly His Arg Asp Gly Ile Trp 
145                 150                 155                 160 


Asp Val Ser Val Ala Lys Thr Gln Pro Val Val Leu Gly Thr Ala Ser 
                165                 170                 175     


Ala Asp His Thr Ala Leu Leu Trp Ser Ile Glu Thr Gly Lys Cys Leu 
            180                 185                 190         


Val Lys Tyr Ala Gly His Val Gly Ser Val Asn Ser Ile Lys Phe His 
        195                 200                 205             


Pro Ser Glu Gln Leu Ala Leu Thr Ala Ser Gly Asp Gln Thr Ala His 
    210                 215                 220                 


Ile Trp Arg Tyr Ala Val Gln Leu Pro Thr Pro Gln Pro Val Ala Asp 
225                 230                 235                 240 


Thr Ser Ile Ser Gly Glu Asp Glu Val Glu Cys Ser Asp Lys Asp Glu 
                245                 250                 255     


Pro Asp Leu Asp Gly Asp Val Ser Ser Asp Cys Pro Thr Ile Arg Val 
            260                 265                 270         


Pro Leu Thr Ser Leu Lys Ser His Gln Gly Val Val Ile Ala Ser Asp 
        275                 280                 285             


Trp Leu Val Gly Gly Lys Gln Ala Val Thr Ala Ser Trp Asp Arg Thr 
    290                 295                 300                 


Ala Asn Leu Tyr Asp Val Glu Thr Ser Glu Leu Val His Ser Leu Thr 
305                 310                 315                 320 


Gly His Asp Gln Glu Leu Thr His Cys Cys Thr His Pro Thr Gln Arg 
                325                 330                 335     


Leu Val Val Thr Ser Ser Arg Asp Thr Thr Phe Arg Leu Trp Asp Phe 
            340                 345                 350         


Arg Asp Pro Ser Ile His Ser Val Asn Val Phe Gln Gly His Thr Asp 
        355                 360                 365             


Thr Val Thr Ser Ala Val Phe Thr Val Gly Asp Asn Val Val Ser Gly 
    370                 375                 380                 


Ser Asp Asp Arg Thr Val Lys Val Trp Asp Leu Lys Asn Met Arg Ser 
385                 390                 395                 400 


Pro Ile Ala Thr Ile Arg Thr Asp Ser Ala Ile Asn Arg Ile Asn Val 
                405                 410                 415     


Cys Val Gly Gln Lys Ile Ile Ala Leu Pro His Asp Asn Arg Gln Val 
            420                 425                 430         


Arg Leu Phe Asp Met Ser Gly Val Arg Leu Ala Arg Leu Pro Arg Ser 
        435                 440                 445             


Ser Arg Gln Gly His Arg Arg Met Val Cys Cys Ser Ala Trp Ser Glu 
    450                 455                 460                 


Asp His Pro Val Cys Asn Leu Phe Thr Cys Gly Phe Asp Arg Gln Ala 
465                 470                 475                 480 


Ile Gly Trp Asn Ile Asn Ile Pro Ala Leu Leu Gln Glu Lys 
                485                 490                 


<210>  994
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  994

Met Thr Ala Glu Glu Thr Val Asn Val Lys Glu Val Glu Ile Ile Lys 
1               5                   10                  15      


Leu Ile Leu Asp Phe Leu Asn Ser Lys Lys Leu His Ile Ser Met Leu 
            20                  25                  30          


Ala Leu Glu Lys Glu Ser Gly Val Ile Asn Gly Leu Phe Ser Asp Asp 
        35                  40                  45              


Met Leu Phe Leu Arg Gln Leu Ile Leu Asp Gly Gln Trp Asp Glu Val 
    50                  55                  60                  


Leu Gln Phe Ile Gln Pro Leu Glu Cys Met Glu Lys Phe Asp Lys Lys 
65                  70                  75                  80  


Arg Phe Arg Tyr Ile Ile Leu Lys Gln Lys Phe Leu Glu Ala Leu Cys 
                85                  90                  95      


Val Asn Asn Ala Met Ser Ala Glu Asp Glu Pro Gln His Leu Glu Phe 
            100                 105                 110         


Thr Met Gln Glu Ala Val Gln Cys Leu His Ala Leu Glu Glu Tyr Cys 
        115                 120                 125             


Pro Ser Lys Asp Asp Tyr Ser Lys Leu Cys Leu Leu Leu Thr Leu Pro 
    130                 135                 140                 


Arg Leu Thr Asn His Ala Glu Phe Lys Asp Trp Asn Pro Ser Thr Ala 
145                 150                 155                 160 


Arg Val His Cys Phe Glu Glu Ala Cys Val Met Val Ala Glu Phe Ile 
                165                 170                 175     


Pro Ala Asp Arg Lys Leu Ser Glu Ala Gly Phe Lys Ala Ser Asn Asn 
            180                 185                 190         


Arg Leu Phe Gln Leu Val Met Lys Gly Leu Leu Tyr Glu Cys Cys Val 
        195                 200                 205             


Glu Phe Cys Gln Ser Lys Ala Thr Gly Glu Glu Ile Thr Glu Ser Glu 
    210                 215                 220                 


Val Leu Leu Gly Ile Asp Leu Leu Cys Gly Asn Gly Cys Asp Asp Leu 
225                 230                 235                 240 


Asp Leu Ser Leu Leu Ser Trp Leu Gln Asn Leu Pro Ser Ser Val Phe 
                245                 250                 255     


Ser Cys Ala Phe Glu Gln Lys Met Leu Asn Ile His Val Asp Lys Leu 
            260                 265                 270         


Leu Lys Pro Thr Lys Ala Ala Tyr Ala Asp Leu Leu Thr Pro Leu Ile 
        275                 280                 285             


Ser Lys Leu Ser Pro Tyr Pro Ser Ser Pro Met Arg Arg Pro Gln Ser 
    290                 295                 300                 


Ala Asp Ala Tyr Met Thr Arg Ser Leu Asn Pro Ala Leu Asp Gly Leu 
305                 310                 315                 320 


Thr Cys Gly Leu Thr Ser His Asp Lys Arg Ile Ser Asp Leu Gly Asn 
                325                 330                 335     


Lys Thr Ser Pro Met Ser His Ser Phe Ala Asn Phe His Tyr Pro Gly 
            340                 345                 350         


Val Gln Asn Leu Ser Arg Ser Leu Met Leu Glu Asn Thr Glu Cys His 
        355                 360                 365             


Ser Ile Tyr Glu Glu Ser Pro Glu Arg Ser Asp Thr Pro Val Asp Ala 
    370                 375                 380                 


Gln Arg Pro Ile Gly Ser Glu Ile Leu Gly Gln Ser Ser Val Ser Glu 
385                 390                 395                 400 


Lys Glu Pro Ala Asn Gly Ala Gln Asn Pro Gly Pro Ala Lys Gln Glu 
                405                 410                 415     


Lys Asn Glu Leu Arg Asp Ser Thr Glu Gln Phe Gln Glu Tyr Tyr Arg 
            420                 425                 430         


Gln Arg Leu Arg Tyr Gln Gln His Leu Glu Gln Lys Glu Gln Gln Arg 
        435                 440                 445             


Gln Ile Tyr Gln Gln Met Leu Leu Glu Gly Gly Val Asn Gln Glu Asp 
    450                 455                 460                 


Gly Pro Asp Gln Gln Gln Asn Leu Thr Glu Gln Phe Leu Asn Arg Ser 
465                 470                 475                 480 


Ile Gln Lys Leu Gly Glu Leu Asn Ile Gly Met Asp Gly Leu Gly Asn 
                485                 490                 495     


Glu Val Ser Ala Leu Asn Gln Gln Cys Asn Gly Ser Lys Gly Asn Gly 
            500                 505                 510         


Ser Asn Gly Ser Ser Val Thr Ser Phe Thr Thr Pro Pro Gln Asp Ser 
        515                 520                 525             


Ser Gln Arg Leu Thr His Asp Ala Ser Asn Ile His Thr Ser Thr Pro 
    530                 535                 540                 


Arg Asn Pro Gly Ser Thr Asn His Ile Pro Phe Leu Glu Glu Ser Pro 
545                 550                 555                 560 


Cys Gly Ser Gln Ile Ser Ser Glu His Ser Val Ile Lys Pro Pro Leu 
                565                 570                 575     


Gly Asp Ser Pro Gly Ser Leu Ser Arg Ser Lys Gly Glu Glu Asp Asp 
            580                 585                 590         


Lys Ser Lys Lys Gln Phe Val Cys Ile Asn Ile Leu Glu Asp Thr Gln 
        595                 600                 605             


Ala Val Arg Ala Val Ala Phe His Pro Ala Gly Gly Leu Tyr Ala Val 
    610                 615                 620                 


Gly Ser Asn Ser Lys Thr Leu Arg Val Cys Ala Tyr Pro Asp Val Ile 
625                 630                 635                 640 


Asp Pro Ser Ala His Glu Thr Pro Lys Gln Pro Val Val Arg Phe Lys 
                645                 650                 655     


Arg Asn Lys His His Lys Gly Ser Ile Tyr Cys Val Ala Trp Ser Pro 
            660                 665                 670         


Cys Gly Gln Leu Leu Ala Thr Gly Ser Asn Asp Lys Tyr Val Lys Val 
        675                 680                 685             


Leu Pro Phe Asn Ala Glu Thr Cys Asn Ala Thr Gly Pro Asp Leu Glu 
    690                 695                 700                 


Phe Ser Met His Asp Gly Thr Ile Arg Asp Leu Ala Phe Met Glu Gly 
705                 710                 715                 720 


Pro Glu Ser Gly Gly Ala Ile Leu Ile Ser Ala Gly Ala Gly Asp Cys 
                725                 730                 735     


Asn Ile Tyr Thr Thr Asp Cys Gln Arg Gly Gln Gly Leu His Ala Leu 
            740                 745                 750         


Ser Gly His Thr Gly His Ile Leu Ala Leu Tyr Thr Trp Ser Gly Trp 
        755                 760                 765             


Met Ile Ala Ser Gly Ser Gln Asp Lys Thr Val Arg Phe Trp Asp Leu 
    770                 775                 780                 


Arg Val Pro Ser Cys Val Arg Val Val Gly Thr Thr Phe His Gly Thr 
785                 790                 795                 800 


Gly Ser Ala Val Ala Ser Val Ala Val Asp Pro Ser Gly Arg Leu Leu 
                805                 810                 815     


Ala Thr Gly Gln Glu Asp Ser Ser Cys Met Leu Tyr Asp Ile Arg Gly 
            820                 825                 830         


Gly Arg Met Val Gln Ser Tyr His Pro His Ser Ser Asp Val Arg Ser 
        835                 840                 845             


Val Arg Phe Ser Pro Gly Ala His Tyr Leu Leu Thr Gly Ser Tyr Asp 
    850                 855                 860                 


Met Lys Ile Lys Val Thr Asp Leu Gln Gly Asp Leu Thr Lys Gln Leu 
865                 870                 875                 880 


Pro Ile Met Val Val Gly Glu His Lys Asp Lys Val Ile Gln Cys Arg 
                885                 890                 895     


Trp His Thr Gln Asp Leu Ser Phe Leu Ser Ser Ser Ala Asp Arg Thr 
            900                 905                 910         


Val Thr Leu Trp Thr Tyr Asn Gly 
        915                 920 


<210>  995
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  995

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Val Gly Cys Thr Met Cys Gln Gln 
    50                  55                  60                  


Ser Met Gln Lys Ser Ser Leu Glu Phe His Lys Ala Asn Glu Cys Gln 
65                  70                  75                  80  


Glu Arg Pro Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser 
                85                  90                  95      


Lys Leu Glu Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys 
            100                 105                 110         


Gln Gly Cys Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg 
        115                 120                 125             


Asp Val Cys Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile 
    130                 135                 140                 


Ser Ala Pro Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile 
145                 150                 155                 160 


Pro Glu Asn Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser 
                165                 170                 175     


Glu Phe Lys Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser 
            180                 185                 190         


Ser Leu Pro Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys 
        195                 200                 205             


Asp Val Arg Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser 
    210                 215                 220                 


Glu Ser Ser Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp 
225                 230                 235                 240 


Pro Leu Leu Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly 
                245                 250                 255     


Asp Lys Ala Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile 
            260                 265                 270         


Leu Leu Pro Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp 
        275                 280                 285             


Leu Ala Ser Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
    290                 295                 300     


<210>  996
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  996

Met Ala Arg Lys Arg Ala Ala Gly Gly Glu Pro Arg Gly Arg Glu Leu 
1               5                   10                  15      


Arg Ser Gln Lys Ser Lys Ala Lys Ser Lys Ala Arg Arg Glu Glu Glu 
            20                  25                  30          


Glu Glu Asp Ala Phe Glu Asp Glu Lys Pro Pro Lys Lys Ser Leu Leu 
        35                  40                  45              


Ser Lys Val Ser Gln Gly Lys Arg Lys Arg Gly Cys Ser His Pro Gly 
    50                  55                  60                  


Gly Ser Ala Asp Gly Pro Ala Lys Lys Lys Val Ala Lys Val Thr Val 
65                  70                  75                  80  


Lys Ser Glu Asn Leu Lys Val Ile Lys Asp Glu Ala Leu Ser Asp Gly 
                85                  90                  95      


Asp Asp Leu Arg Asp Phe Pro Ser Asp Leu Lys Lys Ala His His Leu 
            100                 105                 110         


Lys Arg Gly Ala Thr Met Asn Glu Asp Ser Asn Glu Glu Glu Glu Glu 
        115                 120                 125             


Ser Glu Asn Asp Trp Glu Glu Val Glu Glu Leu Ser Glu Pro Val Leu 
    130                 135                 140                 


Gly Asp Val Arg Glu Ser Thr Ala Phe Ser Arg Ser Leu Leu Pro Val 
145                 150                 155                 160 


Lys Pro Val Glu Ile Glu Ile Glu Thr Pro Glu Gln Ala Lys Thr Arg 
                165                 170                 175     


Glu Arg Ser Glu Lys Ile Lys Leu Glu Phe Glu Thr Tyr Leu Arg Arg 
            180                 185                 190         


Ala Met Lys Arg Phe Asn Lys Gly Val His Glu Asp Thr His Lys Val 
        195                 200                 205             


His Leu Leu Cys Leu Leu Ala Asn Gly Phe Tyr Arg Asn Asn Ile Cys 
    210                 215                 220                 


Ser Gln Pro Asp Leu His Ala Ile Gly Leu Ser Ile Ile Pro Ala Arg 
225                 230                 235                 240 


Phe Thr Arg Val Leu Pro Arg Asp Val Asp Thr Tyr Tyr Leu Ser Asn 
                245                 250                 255     


Leu Val Lys Trp Phe Ile Gly Thr Phe Thr Val Asn Ala Glu Leu Ser 
            260                 265                 270         


Ala Ser Glu Gln Asp Asn Leu Gln Thr Thr Leu Glu Arg Arg Phe Ala 
        275                 280                 285             


Ile Tyr Ser Ala Arg Asp Asp Glu Glu Leu Val His Ile Phe Leu Leu 
    290                 295                 300                 


Ile Leu Arg Ala Leu Gln Leu Leu Thr Arg Leu Val Leu Ser Leu Gln 
305                 310                 315                 320 


Pro Ile Pro Leu Lys Ser Ala Thr Ala Lys Gly Lys Lys Pro Ser Lys 
                325                 330                 335     


Glu Arg Leu Thr Ala Asp Pro Gly Gly Ser Ser Glu Thr Ser Ser Gln 
            340                 345                 350         


Val Leu Glu Asn His Thr Lys Pro Lys Thr Ser Lys Gly Thr Lys Gln 
        355                 360                 365             


Glu Glu Thr Phe Ala Lys Gly Thr Cys Arg Pro Ser Ala Lys Gly Lys 
    370                 375                 380                 


Arg Asn Lys Gly Gly Arg Lys Lys Arg Ser Lys Pro Ser Ser Ser Glu 
385                 390                 395                 400 


Glu Asp Glu Gly Pro Gly Asp Lys Gln Glu Lys Ala Thr Gln Arg Arg 
                405                 410                 415     


Pro His Gly Arg Glu Arg Arg Val Ala Ser Arg Val Ser Tyr Lys Glu 
            420                 425                 430         


Glu Ser Gly Ser Asp Glu Ala Gly Ser Gly Ser Asp Phe Glu Leu Ser 
        435                 440                 445             


Ser Gly Glu Ala Ser Asp Pro Ser Asp Glu Asp Ser Glu Pro Gly Pro 
    450                 455                 460                 


Pro Lys Gln Arg Lys Ala Pro Ala Pro Gln Arg Thr Lys Ala Gly Ser 
465                 470                 475                 480 


Lys Ser Ala Ser Arg Thr His Arg Gly Ser His Arg Lys Asp Pro Ser 
                485                 490                 495     


Leu Pro Ala Ala Ser Ser Ser Ser Ser Ser Ser Lys Arg Gly Lys Lys 
            500                 505                 510         


Met Cys Ser Asp Gly Glu Lys Ala Glu Lys Arg Ser Ile Ala Gly Ile 
        515                 520                 525             


Asp Gln Trp Leu Glu Val Phe Cys Glu Gln Glu Glu Lys Trp Val Cys 
    530                 535                 540                 


Val Asp Cys Val His Gly Val Val Gly Gln Pro Leu Thr Cys Tyr Lys 
545                 550                 555                 560 


Tyr Ala Thr Lys Pro Met Thr Tyr Val Val Gly Ile Asp Ser Asp Gly 
                565                 570                 575     


Trp Val Arg Asp Val Thr Gln Arg Tyr Asp Pro Val Trp Met Thr Val 
            580                 585                 590         


Thr Arg Lys Cys Arg Val Asp Ala Glu Trp Trp Ala Glu Thr Leu Arg 
        595                 600                 605             


Pro Tyr Gln Ser Pro Phe Met Asp Arg Glu Lys Lys Glu Asp Leu Glu 
    610                 615                 620                 


Phe Gln Ala Lys His Met Asp Gln Pro Leu Pro Thr Ala Ile Gly Leu 
625                 630                 635                 640 


Tyr Lys Asn His Pro Leu Tyr Ala Leu Lys Arg His Leu Leu Lys Tyr 
                645                 650                 655     


Glu Ala Ile Tyr Pro Glu Thr Ala Ala Ile Leu Gly Tyr Cys Arg Gly 
            660                 665                 670         


Glu Ala Val Tyr Ser Arg Asp Cys Val His Thr Leu His Ser Arg Asp 
        675                 680                 685             


Thr Trp Leu Lys Lys Ala Arg Val Val Arg Leu Gly Glu Val Pro Tyr 
    690                 695                 700                 


Lys Met Val Lys Gly Phe Ser Asn Arg Ala Arg Lys Ala Arg Leu Ala 
705                 710                 715                 720 


Glu Pro Gln Leu Arg Glu Glu Asn Asp Leu Gly Leu Phe Gly Tyr Trp 
                725                 730                 735     


Gln Thr Glu Glu Tyr Gln Pro Pro Val Ala Val Asp Gly Lys Val Pro 
            740                 745                 750         


Arg Asn Glu Phe Gly Asn Val Tyr Leu Phe Leu Pro Ser Met Met Pro 
        755                 760                 765             


Ile Gly Cys Val Gln Leu Asn Leu Pro Asn Leu His Arg Val Ala Arg 
    770                 775                 780                 


Lys Leu Asp Ile Asp Cys Val Gln Ala Ile Thr Gly Phe Asp Phe His 
785                 790                 795                 800 


Gly Gly Tyr Ser His Pro Val Thr Asp Gly Tyr Ile Val Cys Glu Glu 
                805                 810                 815     


Phe Lys Asp Val Leu Leu Thr Ala Trp Glu Asn Glu Gln Ala Val Ile 
            820                 825                 830         


Glu Arg Lys Glu Lys Glu Lys Lys Glu Lys Arg Ala Leu Gly Asn Trp 
        835                 840                 845             


Lys Leu Leu Ala Lys Gly Leu Leu Ile Arg Glu Arg Leu Lys Arg Arg 
    850                 855                 860                 


Tyr Gly Pro Lys Ser Glu Ala Ala Ala Pro His Thr Asp Ala Gly Gly 
865                 870                 875                 880 


Gly Leu Ser Ser Asp Glu Glu Glu Gly Thr Ser Ser Gln Ala Glu Ala 
                885                 890                 895     


Ala Arg Ile Leu Ala Ala Ser Trp Pro Gln Asn Arg Glu Asp Glu Glu 
            900                 905                 910         


Lys Gln Lys Leu Lys Gly Gly Pro Lys Lys Thr Lys Arg Glu Lys Lys 
        915                 920                 925             


Ala Ala Ala Ser His Leu Phe Pro Phe Glu Gln Leu 
    930                 935                 940 


<210>  997
<211>  1125
<212>  PRT
<213>  Homo sapiens

<400>  997

Met Ala Ser Glu Glu Ala Ser Leu Arg Ala Leu Glu Ser Leu Met Thr 
1               5                   10                  15      


Glu Phe Phe His Asp Cys Thr Thr Asn Glu Arg Lys Arg Glu Ile Glu 
            20                  25                  30          


Glu Leu Leu Asn Asn Phe Ala Gln Gln Ile Gly Ala Trp Arg Phe Cys 
        35                  40                  45              


Leu Tyr Phe Leu Ser Ser Thr Arg Asn Asp Tyr Val Met Met Tyr Ser 
    50                  55                  60                  


Leu Thr Val Phe Glu Asn Leu Ile Asn Lys Met Trp Leu Gly Val Pro 
65                  70                  75                  80  


Ser Gln Asp Lys Met Glu Ile Arg Ser Cys Leu Pro Lys Leu Leu Leu 
                85                  90                  95      


Ala His His Lys Thr Leu Pro Tyr Phe Ile Arg Asn Lys Leu Cys Lys 
            100                 105                 110         


Val Ile Val Asp Ile Gly Arg Gln Asp Trp Pro Met Phe Tyr His Asp 
        115                 120                 125             


Phe Phe Thr Asn Ile Leu Gln Leu Ile Gln Ser Pro Val Thr Thr Pro 
    130                 135                 140                 


Leu Gly Leu Ile Met Leu Lys Thr Thr Ser Glu Glu Leu Ala Cys Pro 
145                 150                 155                 160 


Arg Glu Asp Leu Ser Val Ala Arg Lys Glu Glu Leu Arg Lys Leu Leu 
                165                 170                 175     


Leu Asp Gln Val Gln Thr Val Leu Gly Leu Leu Thr Gly Ile Leu Glu 
            180                 185                 190         


Thr Val Trp Asp Lys His Ser Val Thr Ala Ala Thr Pro Pro Pro Ser 
        195                 200                 205             


Pro Thr Ser Gly Glu Ser Gly Asp Leu Leu Ser Asn Leu Leu Gln Ser 
    210                 215                 220                 


Pro Ser Ser Ala Lys Leu Leu Asn Gln Pro Ile Pro Ile Leu Asp Val 
225                 230                 235                 240 


Glu Ser Glu Tyr Ile Cys Ser Leu Ala Leu Glu Cys Leu Ala His Leu 
                245                 250                 255     


Phe Ser Trp Ile Pro Leu Ser Ala Ser Ile Thr Pro Ser Leu Leu Thr 
            260                 265                 270         


Thr Ile Phe His Phe Ala Arg Phe Gly Cys Asp Ile Arg Ala Arg Lys 
        275                 280                 285             


Met Ala Ser Val Asn Gly Ser Ser Gln Asn Cys Val Ser Gly Gln Glu 
    290                 295                 300                 


Arg Gly Arg Leu Gly Val Leu Ala Met Ser Cys Ile Asn Glu Leu Met 
305                 310                 315                 320 


Ser Lys Asn Cys Val Pro Met Glu Phe Glu Glu Tyr Leu Leu Arg Met 
                325                 330                 335     


Phe Gln Gln Thr Phe Tyr Leu Leu Gln Lys Ile Thr Lys Asp Asn Asn 
            340                 345                 350         


Ala His Thr Val Lys Ser Arg Leu Glu Glu Leu Asp Glu Ser Tyr Ile 
        355                 360                 365             


Glu Lys Phe Thr Asp Phe Leu Arg Leu Phe Val Ser Val His Leu Arg 
    370                 375                 380                 


Arg Ile Glu Ser Tyr Ser Gln Phe Pro Val Val Glu Phe Leu Thr Leu 
385                 390                 395                 400 


Leu Phe Lys Tyr Thr Phe His Gln Pro Thr His Glu Gly Tyr Phe Ser 
                405                 410                 415     


Cys Leu Asp Ile Trp Thr Leu Phe Leu Asp Tyr Leu Thr Ser Lys Ile 
            420                 425                 430         


Lys Ser Arg Leu Gly Asp Lys Glu Ala Val Leu Asn Arg Tyr Glu Asp 
        435                 440                 445             


Ala Leu Val Leu Leu Leu Thr Glu Val Leu Asn Arg Ile Gln Phe Arg 
    450                 455                 460                 


Tyr Asn Gln Ala Gln Leu Glu Glu Leu Asp Asp Glu Thr Leu Asp Asp 
465                 470                 475                 480 


Asp Gln Gln Thr Glu Trp Gln Arg Tyr Leu Arg Gln Ser Leu Glu Val 
                485                 490                 495     


Val Ala Lys Val Met Glu Leu Leu Pro Thr His Ala Phe Ser Thr Leu 
            500                 505                 510         


Phe Pro Val Leu Gln Asp Asn Leu Glu Val Tyr Leu Gly Leu Gln Gln 
        515                 520                 525             


Phe Ile Val Thr Ser Gly Ser Gly His Arg Leu Asn Ile Thr Ala Glu 
    530                 535                 540                 


Asn Asp Cys Arg Arg Leu His Cys Ser Leu Arg Asp Leu Ser Ser Leu 
545                 550                 555                 560 


Leu Gln Ala Val Gly Arg Leu Ala Glu Tyr Phe Ile Gly Asp Val Phe 
                565                 570                 575     


Ala Ala Arg Phe Asn Asp Ala Leu Thr Val Val Glu Arg Leu Val Lys 
            580                 585                 590         


Val Thr Leu Tyr Gly Ser Gln Ile Lys Leu Tyr Asn Ile Glu Thr Ala 
        595                 600                 605             


Val Pro Ser Val Leu Lys Pro Asp Leu Ile Asp Val His Ala Gln Ser 
    610                 615                 620                 


Leu Ala Ala Leu Gln Ala Tyr Ser His Trp Leu Ala Gln Tyr Cys Ser 
625                 630                 635                 640 


Glu Val His Arg Gln Asn Thr Gln Gln Phe Val Thr Leu Ile Ser Thr 
                645                 650                 655     


Thr Met Asp Ala Ile Thr Pro Leu Ile Ser Thr Lys Val Gln Asp Lys 
            660                 665                 670         


Leu Leu Leu Ser Ala Cys His Leu Leu Val Ser Leu Ala Thr Thr Val 
        675                 680                 685             


Arg Pro Val Phe Leu Ile Ser Ile Pro Ala Val Gln Lys Val Phe Asn 
    690                 695                 700                 


Arg Ile Thr Asp Ala Ser Ala Leu Arg Leu Val Asp Lys Ala Gln Val 
705                 710                 715                 720 


Leu Val Cys Arg Ala Leu Ser Asn Ile Leu Leu Leu Pro Trp Pro Asn 
                725                 730                 735     


Leu Pro Glu Asn Glu Gln Gln Trp Pro Val Arg Ser Ile Asn His Ala 
            740                 745                 750         


Ser Leu Ile Ser Ala Leu Ser Arg Asp Tyr Arg Asn Leu Lys Pro Ser 
        755                 760                 765             


Ala Val Ala Pro Gln Arg Lys Met Pro Leu Asp Asp Thr Lys Leu Ile 
    770                 775                 780                 


Ile His Gln Thr Leu Ser Val Leu Glu Asp Ile Val Glu Asn Ile Ser 
785                 790                 795                 800 


Gly Glu Ser Thr Lys Ser Arg Gln Ile Cys Tyr Gln Ser Leu Gln Glu 
                805                 810                 815     


Ser Val Gln Val Ser Leu Ala Leu Phe Pro Ala Phe Ile His Gln Ser 
            820                 825                 830         


Asp Val Thr Asp Glu Met Leu Ser Phe Phe Leu Thr Leu Phe Arg Gly 
        835                 840                 845             


Leu Arg Val Gln Met Gly Val Pro Phe Thr Glu Gln Ile Ile Gln Thr 
    850                 855                 860                 


Phe Leu Asn Met Phe Thr Arg Glu Gln Leu Ala Glu Ser Ile Leu His 
865                 870                 875                 880 


Glu Gly Ser Thr Gly Cys Arg Val Val Glu Lys Phe Leu Lys Ile Leu 
                885                 890                 895     


Gln Val Val Val Gln Glu Pro Gly Gln Val Phe Lys Pro Phe Leu Pro 
            900                 905                 910         


Ser Ile Ile Ala Leu Cys Met Glu Gln Val Tyr Pro Ile Ile Ala Glu 
        915                 920                 925             


Arg Pro Ser Pro Asp Val Lys Ala Glu Leu Phe Glu Leu Leu Phe Arg 
    930                 935                 940                 


Thr Leu His His Asn Trp Arg Tyr Phe Phe Lys Ser Thr Val Leu Ala 
945                 950                 955                 960 


Ser Val Gln Arg Gly Ile Ala Glu Glu Gln Met Glu Asn Glu Pro Gln 
                965                 970                 975     


Phe Ser Ala Ile Met Gln Ala Phe Gly Gln Ser Phe Leu Gln Pro Asp 
            980                 985                 990         


Ile His Leu Phe Lys Gln Asn Leu  Phe Tyr Leu Glu Thr  Leu Asn Thr 
        995                 1000                 1005             


Lys Gln  Lys Leu Tyr His Lys  Lys Ile Phe Arg Thr  Ala Met Leu 
    1010                 1015                 1020             


Phe Gln  Phe Val Asn Val Leu  Leu Gln Val Leu Val  His Lys Ser 
    1025                 1030                 1035             


His Asp  Leu Leu Gln Glu Glu  Ile Gly Ile Ala Ile  Tyr Asn Met 
    1040                 1045                 1050             


Ala Ser  Val Asp Phe Asp Gly  Phe Phe Ala Ala Phe  Leu Pro Glu 
    1055                 1060                 1065             


Phe Leu  Thr Ser Cys Asp Gly  Val Asp Ala Asn Gln  Lys Ser Val 
    1070                 1075                 1080             


Leu Gly  Arg Asn Phe Lys Met  Asp Arg Asp Leu Pro  Ser Phe Thr 
    1085                 1090                 1095             


Gln Asn  Val His Arg Leu Val  Asn Asp Leu Arg Tyr  Tyr Arg Leu 
    1100                 1105                 1110             


Cys Asn  Asp Ser Leu Pro Pro  Gly Thr Val Lys Leu  
    1115                 1120                 1125 


<210>  998
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  998

Met Gly Arg Ile Phe Leu Asp His Ile Gly Gly Thr Arg Leu Phe Ser 
1               5                   10                  15      


Cys Ala Asn Cys Asp Thr Ile Leu Thr Asn Arg Ser Glu Leu Ile Ser 
            20                  25                  30          


Thr Arg Phe Thr Gly Ala Thr Gly Arg Ala Phe Leu Phe Asn Lys Val 
        35                  40                  45              


Val Asn Leu Gln Tyr Ser Glu Val Gln Asp Arg Val Met Leu Thr Gly 
    50                  55                  60                  


Arg His Met Val Arg Asp Val Ser Cys Lys Asn Cys Asn Ser Lys Leu 
65                  70                  75                  80  


Gly Trp Ile Tyr Glu Phe Ala Thr Glu Asp Ser Gln Arg Tyr Lys Glu 
                85                  90                  95      


Gly Arg Val Ile Leu Glu Arg Ala Leu Val Arg Glu Ser Glu Gly Phe 
            100                 105                 110         


Glu Glu His Val Pro Ser Asp Asn Ser 
        115                 120     


<210>  999
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  999

Met Ser Ala Thr Ser Val Asp Gln Arg Pro Lys Gly Gln Gly Asn Lys 
1               5                   10                  15      


Val Ser Val Gln Asn Gly Ser Ile His Gln Lys Asp Ala Val Asn Asp 
            20                  25                  30          


Asp Asp Phe Glu Pro Tyr Leu Ser Ser Gln Thr Asn Gln Ser Asn Ser 
        35                  40                  45              


Tyr Pro Pro Met Ser Asp Pro Tyr Met Pro Ser Tyr Tyr Ala Pro Ser 
    50                  55                  60                  


Ile Gly Phe Pro Tyr Ser Leu Gly Glu Ala Ala Trp Ser Thr Ala Gly 
65                  70                  75                  80  


Asp Gln Pro Met Pro Tyr Leu Thr Thr Tyr Gly Gln Met Ser Asn Gly 
                85                  90                  95      


Glu His His Tyr Ile Pro Asp Gly Val Phe Ser Gln Pro Gly Ala Leu 
            100                 105                 110         


Gly Asn Thr Pro Pro Phe Leu Gly Gln His Gly Phe Asn Phe Phe Pro 
        115                 120                 125             


Gly Asn Ala Asp Phe Ser Thr Trp Gly Thr Ser Gly Ser Gln Gly Gln 
    130                 135                 140                 


Ser Thr Gln Ser Ser Ala Tyr Ser Ser Ser Tyr Gly Tyr Pro Pro Ser 
145                 150                 155                 160 


Ser Leu Gly Arg Ala Ile Thr Asp Gly Gln Ala Gly Phe Gly Asn Asp 
                165                 170                 175     


Thr Leu Ser Lys Val Pro Gly Ile Ser Ser Ile Glu Gln Gly Met Thr 
            180                 185                 190         


Gly Leu Lys Ile Gly Gly Asp Leu Thr Ala Ala Val Thr Lys Thr Val 
        195                 200                 205             


Gly Thr Ala Leu Ser Ser Ser Gly Met Thr Ser Ile Ala Thr Asn Ser 
    210                 215                 220                 


Val Pro Pro Val Ser Ser Ala Ala Pro Lys Pro Thr Ser Trp Ala Ala 
225                 230                 235                 240 


Ile Ala Arg Lys Pro Ala Lys Pro Gln Pro Lys Leu Lys Pro Lys Gly 
                245                 250                 255     


Asn Val Gly Ile Gly Gly Ser Ala Val Pro Pro Pro Pro Ile Lys His 
            260                 265                 270         


Asn Met Asn Ile Gly Thr Trp Asp Glu Lys Gly Ser Val Val Lys Ala 
        275                 280                 285             


Pro Pro Thr Gln Pro Val Leu Pro Pro Gln Thr Ile Ile Gln Gln Pro 
    290                 295                 300                 


Gln Pro Leu Ile Gln Pro Pro Pro Leu Val Gln Ser Gln Leu Pro Gln 
305                 310                 315                 320 


Gln Gln Pro Gln Pro Pro Gln Pro Gln Gln Gln Gln Gly Pro Gln Pro 
                325                 330                 335     


Gln Ala Gln Pro His Gln Val Gln Pro Gln Gln Gln Gln Leu Gln Asn 
            340                 345                 350         


Arg Trp Val Ala Pro Arg Asn Arg Gly Ala Gly Phe Asn Gln Asn Asn 
        355                 360                 365             


Gly Ala Gly Ser Glu Asn Phe Gly Leu Gly Val Val Pro Val Ser Ala 
    370                 375                 380                 


Ser Pro Ser Ser Val Glu Val His Pro Val Leu Glu Lys Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Asn Tyr Asn Pro Lys Asp Phe Asp Trp Asn Leu Lys Asn Gly 
                405                 410                 415     


Arg Val Phe Ile Ile Lys Ser Tyr Ser Glu Asp Asp Ile His Arg Ser 
            420                 425                 430         


Ile Lys Tyr Ser Ile Trp Cys Ser Thr Glu His Gly Asn Lys Arg Leu 
        435                 440                 445             


Asp Ala Ala Tyr Arg Ser Leu Asn Gly Lys Gly Pro Leu Tyr Leu Leu 
    450                 455                 460                 


Phe Ser Val Asn Gly Ser Gly His Phe Cys Gly Val Ala Glu Met Lys 
465                 470                 475                 480 


Ser Val Val Asp Tyr Asn Ala Tyr Ala Gly Val Trp Ser Gln Asp Lys 
                485                 490                 495     


Trp Lys Gly Lys Phe Glu Val Lys Trp Ile Phe Val Lys Asp Val Pro 
            500                 505                 510         


Asn Asn Gln Leu Arg His Ile Arg Leu Glu Asn Asn Asp Asn Lys Pro 
        515                 520                 525             


Val Thr Asn Ser Arg Asp Thr Gln Glu Val Pro Leu Glu Lys Ala Lys 
    530                 535                 540                 


Gln Val Leu Lys Ile Ile Ala Thr Phe Lys His Thr Thr Ser Ile Phe 
545                 550                 555                 560 


Asp Asp Phe Ala His Tyr Glu Lys Arg Gln Glu Glu Glu Glu Ala Met 
                565                 570                 575     


Arg Arg Glu Arg Asn Arg Asn Lys Gln 
            580                 585 


<210>  1000
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1000

Met Glu Phe Pro Asp His Ser Arg His Leu Leu Gln Cys Leu Ser Glu 
1               5                   10                  15      


Gln Arg His Gln Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 
            20                  25                  30          


Ala Gln Phe Arg Ala His Arg Ala Val Leu Ala Ser Cys Ser Met Tyr 
        35                  40                  45              


Phe His Leu Phe Tyr Lys Asp Gln Leu Asp Lys Arg Asp Ile Val His 
    50                  55                  60                  


Leu Asn Ser Asp Ile Val Thr Ala Pro Ala Phe Ala Leu Leu Leu Glu 
65                  70                  75                  80  


Phe Met Tyr Glu Gly Lys Leu Gln Phe Lys Asp Leu Pro Ile Glu Asp 
                85                  90                  95      


Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys Val 
            100                 105                 110         


Cys Lys Lys Lys Leu Lys Glu Lys Ala Thr Thr Glu Ala Asp Ser Thr 
        115                 120                 125             


Lys Lys Glu Glu Asp Ala Ser Ser Cys Ser Asp Lys Val Glu Ser Leu 
    130                 135                 140                 


Ser Asp Gly Ser Ser His Ile Ala Gly Asp Leu Pro Ser Asp Glu Asp 
145                 150                 155                 160 


Glu Gly Glu Asp Glu Lys Leu Asn Ile Leu Pro Ser Lys Arg Asp Leu 
                165                 170                 175     


Ala Ala Glu Pro Gly Asn Met Trp Met Arg Leu Pro Ser Asp Ser Ala 
            180                 185                 190         


Gly Ile Pro Gln Ala Gly Gly Glu Ala Glu Pro His Ala Thr Ala Ala 
        195                 200                 205             


Gly Lys Thr Val Ala Ser Pro Cys Ser Ser Thr Glu Ser Leu Ser Gln 
    210                 215                 220                 


Arg Ser Val Thr Ser Val Arg Asp Ser Ala Asp Val Asp Cys Val Leu 
225                 230                 235                 240 


Asp Leu Ser Val Lys Ser Ser Leu Ser Gly Val Glu Asn Leu Asn Ser 
                245                 250                 255     


Ser Tyr Phe Ser Ser Gln Asp Val Leu Arg Ser Asn Leu Val Gln Val 
            260                 265                 270         


Lys Val Glu Lys Glu Ala Ser Cys Asp Glu Ser Asp Val Gly Thr Asn 
        275                 280                 285             


Asp Tyr Asp Met Glu His Ser Thr Val Lys Glu Ser Val Ser Thr Asn 
    290                 295                 300                 


Asn Arg Val Gln Tyr Glu Pro Ala His Leu Ala Pro Leu Arg Glu Asp 
305                 310                 315                 320 


Ser Val Leu Arg Glu Leu Asp Arg Glu Asp Lys Ala Ser Asp Asp Glu 
                325                 330                 335     


Met Met Thr Pro Glu Ser Glu Arg Val Gln Val Glu Gly Gly Met Glu 
            340                 345                 350         


Ser Ser Leu Leu Pro Tyr Val Ser Asn Ile Leu Ser Pro Ala Gly Gln 
        355                 360                 365             


Ile Phe Met Cys Pro Leu Cys Asn Lys Val Phe Pro Ser Pro His Ile 
    370                 375                 380                 


Leu Gln Ile His Leu Ser Thr His Phe Arg Glu Gln Asp Gly Ile Arg 
385                 390                 395                 400 


Ser Lys Pro Ala Ala Asp Val Asn Val Pro Thr Cys Ser Leu Cys Gly 
                405                 410                 415     


Lys Thr Phe Ser Cys Met Tyr Thr Leu Lys Arg His Glu Arg Thr His 
            420                 425                 430         


Ser Gly Glu Lys Pro Tyr Thr Cys Thr Gln Cys Gly Lys Ser Phe Gln 
        435                 440                 445             


Tyr Ser His Asn Leu Ser Arg His Ala Val Val His Thr Arg Glu Lys 
    450                 455                 460                 


Pro His Ala Cys Lys Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp 
465                 470                 475                 480 


Leu Tyr Arg His Ile Arg Lys Phe His Cys Glu Leu Val Asn Ser Leu 
                485                 490                 495     


Ser Val Lys Ser Glu Ala Leu Ser Leu Pro Thr Val Arg Asp Trp Thr 
            500                 505                 510         


Leu Glu Asp Ser Ser Gln Glu Leu Trp Lys 
        515                 520         


<210>  1001
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  1001

Met Ala Asp Pro Glu Val Cys Cys Phe Ile Thr Lys Ile Leu Cys Ala 
1               5                   10                  15      


His Gly Gly Arg Met Ala Leu Asp Ala Leu Leu Gln Glu Ile Ala Leu 
            20                  25                  30          


Ser Glu Pro Gln Leu Cys Glu Val Leu Gln Val Ala Gly Pro Asp Arg 
        35                  40                  45              


Phe Val Val Leu Glu Thr Gly Gly Glu Ala Gly Ile Thr Arg Ser Val 
    50                  55                  60                  


Val Ala Thr Thr Arg Ala Arg Val Cys Arg Arg Lys Tyr Cys Gln Arg 
65                  70                  75                  80  


Pro Cys Asp Asn Leu His Leu Cys Lys Leu Asn Leu Leu Gly Arg Cys 
                85                  90                  95      


Asn Tyr Ser Gln Ser Glu Arg Asn Leu Cys Lys Tyr Ser His Glu Val 
            100                 105                 110         


Leu Ser Glu Glu Asn Phe Lys Val Leu Lys Asn His Glu Leu Ser Gly 
        115                 120                 125             


Leu Asn Lys Glu Glu Leu Ala Val Leu Leu Leu Gln Ser Asp Pro Phe 
    130                 135                 140                 


Phe Met Pro Glu Ile Cys Lys Ser Tyr Lys Gly Glu Gly Arg Gln Gln 
145                 150                 155                 160 


Ile Cys Asn Gln Gln Pro Pro Cys Ser Arg Leu His Ile Cys Asp His 
                165                 170                 175     


Phe Thr Arg Gly Asn Cys Arg Phe Pro Asn Cys Leu Arg Ser His Asn 
            180                 185                 190         


Leu Met Asp Arg Lys Val Leu Ala Ile Met Arg Glu His Gly Leu Asn 
        195                 200                 205             


Pro Asp Val Val Gln Asn Ile Gln Asp Ile Cys Asn Ser Lys His Met 
    210                 215                 220                 


Gln Lys Asn Pro Pro Gly Pro Arg Ala Pro Ser Ser His Arg Arg Asn 
225                 230                 235                 240 


Met Ala Tyr Arg Ala Arg Ser Lys Ser Arg Asp Arg Phe Phe Gln Gly 
                245                 250                 255     


Ser Gln Glu Phe Leu Ala Ser Ala Ser Ala Ser Ala Glu Arg Ser Cys 
            260                 265                 270         


Thr Pro Ser Pro Asp Gln Ile Ser His Arg Ala Ser Leu Glu Asp Ala 
        275                 280                 285             


Pro Val Asp Asp Leu Thr Arg Lys Phe Thr Tyr Leu Gly Ser Gln Asp 
    290                 295                 300                 


Arg Ala Arg Pro Pro Ser Gly Ser Ser Lys Ala Thr Asp Leu Gly Gly 
305                 310                 315                 320 


Thr Ser Gln Ala Gly Thr Ser Gln Arg Phe Leu Glu Asn Gly Ser Gln 
                325                 330                 335     


Glu Asp Leu Leu His Gly Asn Pro Gly Ser Thr Tyr Leu Ala Ser Asn 
            340                 345                 350         


Ser Thr Ser Ala Pro Asn Trp Lys Ser Leu Thr Ser Trp Thr Asn Asp 
        355                 360                 365             


Gln Gly Ala Arg Arg Lys Thr Val Phe Ser Pro Thr Leu Pro Ala Ala 
    370                 375                 380                 


Arg Ser Ser Leu Gly Ser Leu Gln Thr Pro Glu Ala Val Thr Thr Arg 
385                 390                 395                 400 


Lys Gly Thr Gly Leu Leu Ser Ser Asp Tyr Arg Ile Ile Asn Gly Lys 
                405                 410                 415     


Ser Gly Thr Gln Asp Ile Gln Pro Gly Pro Leu Phe Asn Asn Asn Ala 
            420                 425                 430         


Asp Gly Val Ala Thr Asp Ile Thr Ser Thr Arg Ser Leu Asn Tyr Lys 
        435                 440                 445             


Ser Thr Ser Ser Gly His Arg Glu Ile Ser Ser Pro Arg Ile Gln Asp 
    450                 455                 460                 


Ala Gly Pro Ala Ser Arg Asp Val Gln Ala Thr Gly Arg Ile Ala Asp 
465                 470                 475                 480 


Asp Ala Asp Pro Arg Val Ala Leu Val Asn Asp Ser Leu Ser Asp Val 
                485                 490                 495     


Thr Ser Thr Thr Ser Ser Arg Val Asp Asp His Asp Ser Glu Glu Ile 
            500                 505                 510         


Cys Leu Asp His Leu Cys Lys Gly Cys Pro Leu Asn Gly Ser Cys Ser 
        515                 520                 525             


Lys Val His Phe His Leu Pro Tyr Arg Trp Gln Met Leu Ile Gly Lys 
    530                 535                 540                 


Thr Trp Thr Asp Phe Glu His Met Glu Thr Ile Glu Lys Gly Tyr Cys 
545                 550                 555                 560 


Asn Pro Gly Ile His Leu Cys Ser Val Gly Ser Tyr Thr Ile Asn Phe 
                565                 570                 575     


Arg Val Met Ser Cys Asp Ser Phe Pro Ile Arg Arg Leu Ser Thr Pro 
            580                 585                 590         


Ser Ser Val Thr Lys Pro Ala Asn Ser Val Phe Thr Thr Lys Trp Ile 
        595                 600                 605             


Trp Tyr Trp Lys Asn Glu Ser Gly Thr Trp Ile Gln Tyr Gly Glu Glu 
    610                 615                 620                 


Lys Asp Lys Arg Lys Asn Ser Asn Val Asp Ser Ser Tyr Leu Glu Ser 
625                 630                 635                 640 


Leu Tyr Gln Ser Cys Pro Arg Gly Val Val Pro Phe Gln Ala Gly Ser 
                645                 650                 655     


Arg Asn Tyr Glu Leu Ser Phe Gln Gly Met Ile Gln Thr Asn Ile Ala 
            660                 665                 670         


Ser Lys Thr Gln Lys Asp Val Ile Arg Arg Pro Thr Phe Val Pro Gln 
        675                 680                 685             


Trp Tyr Val Gln Gln Met Lys Arg Gly Pro Asp His Gln Pro Ala Lys 
    690                 695                 700                 


Thr Ser Ser Val Ser Leu Thr Ala Thr Phe Arg Pro Gln Glu Asp Phe 
705                 710                 715                 720 


Cys Phe Leu Ser Ser Lys Lys Tyr Lys Leu Ser Glu Ile His His Leu 
                725                 730                 735     


His Pro Glu Tyr Val Arg Val Ser Glu His Phe Lys Ala Ser Met Lys 
            740                 745                 750         


Asn Phe Lys Ile Glu Lys Ile Lys Lys Ile Glu Asn Ser Glu Leu Leu 
        755                 760                 765             


Asp Lys Phe Thr Trp Lys Lys Ser Gln Met Lys Glu Glu Gly Lys Leu 
    770                 775                 780                 


Leu Phe Tyr Ala Thr Ser Arg Ala Tyr Val Glu Ser Ile Cys Ser Asn 
785                 790                 795                 800 


Asn Phe Asp Ser Phe Leu His Glu Thr His Glu Asn Lys Tyr Gly Lys 
                805                 810                 815     


Gly Ile Tyr Phe Ala Lys Asp Ala Ile Tyr Ser His Lys Asn Cys Pro 
            820                 825                 830         


Tyr Asp Ala Lys Asn Val Val Met Phe Val Ala Gln Val Leu Val Gly 
        835                 840                 845             


Lys Phe Thr Glu Gly Asn Ile Thr Tyr Thr Ser Pro Pro Pro Gln Phe 
    850                 855                 860                 


Asp Ser Cys Val Asp Thr Arg Ser Asn Pro Ser Val Phe Val Ile Phe 
865                 870                 875                 880 


Gln Lys Asp Gln Val Tyr Pro Gln Tyr Val Ile Glu Tyr Thr Glu Asp 
                885                 890                 895     


Lys Ala Cys Val Ile Ser 
            900         


<210>  1002
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  1002

Met Gln Arg Glu Glu Gly Phe Asn Thr Lys Met Ala Asp Gly Pro Asp 
1               5                   10                  15      


Glu Tyr Asp Thr Glu Ala Gly Cys Val Pro Leu Leu His Pro Glu Glu 
            20                  25                  30          


Ile Lys Pro Gln Ser His Tyr Asn His Gly Tyr Gly Glu Pro Leu Gly 
        35                  40                  45              


Arg Lys Thr His Ile Asp Asp Tyr Ser Thr Trp Asp Ile Val Lys Ala 
    50                  55                  60                  


Thr Gln Tyr Gly Ile Tyr Glu Arg Cys Arg Glu Leu Val Glu Ala Gly 
65                  70                  75                  80  


Tyr Asp Val Arg Gln Pro Asp Lys Glu Asn Val Thr Leu Leu His Trp 
                85                  90                  95      


Ala Ala Ile Asn Asn Arg Ile Asp Leu Val Lys Tyr Tyr Ile Ser Lys 
            100                 105                 110         


Gly Ala Ile Val Asp Gln Leu Gly Gly Asp Leu Asn Ser Thr Pro Leu 
        115                 120                 125             


His Trp Ala Thr Arg Gln Gly His Leu Ser Met Val Val Gln Leu Met 
    130                 135                 140                 


Lys Tyr Gly Ala Asp Pro Ser Leu Ile Asp Gly Glu Gly Cys Ser Cys 
145                 150                 155                 160 


Ile His Leu Ala Ala Gln Phe Gly His Thr Ser Ile Val Ala Tyr Leu 
                165                 170                 175     


Ile Ala Lys Gly Gln Asp Val Asp Met Met Asp Gln Asn Gly Met Thr 
            180                 185                 190         


Pro Leu Met Trp Ala Ala Tyr Arg Thr His Ser Val Asp Pro Thr Arg 
        195                 200                 205             


Leu Leu Leu Thr Phe Asn Val Ser Val Asn Leu Gly Asp Lys Tyr His 
    210                 215                 220                 


Lys Asn Thr Ala Leu His Trp Ala Val Leu Ala Gly Asn Thr Thr Val 
225                 230                 235                 240 


Ile Ser Leu Leu Leu Glu Ala Gly Ala Asn Val Asp Ala Gln Asn Ile 
                245                 250                 255     


Lys Gly Glu Ser Ala Leu Asp Leu Ala Lys Gln Arg Lys Asn Val Trp 
            260                 265                 270         


Met Ile Asn His Leu Gln Glu Ala Arg Gln Ala Lys Gly Tyr Asp Asn 
        275                 280                 285             


Pro Ser Phe Leu Arg Lys Leu Lys Ala Asp Lys Glu Phe Arg Gln Lys 
    290                 295                 300                 


Val Met Leu Gly Thr Pro Phe Leu Val Ile Trp Leu Val Gly Phe Ile 
305                 310                 315                 320 


Ala Asp Leu Asn Ile Asp Ser Trp Leu Ile Lys Gly Leu Met Tyr Gly 
                325                 330                 335     


Gly Val Trp Ala Thr Val Gln Phe Leu Ser Lys Ser Phe Phe Asp His 
            340                 345                 350         


Ser Met His Ser Ala Leu Pro Leu Gly Ile Tyr Leu Ala Thr Lys Phe 
        355                 360                 365             


Trp Met Tyr Val Thr Trp Phe Phe Trp Phe Trp Asn Asp Leu Asn Phe 
    370                 375                 380                 


Leu Phe Ile His Leu Pro Phe Leu Ala Asn Ser Val Ala Leu Phe Tyr 
385                 390                 395                 400 


Asn Phe Gly Lys Ser Trp Lys Ser Asp Pro Gly Ile Ile Lys Ala Thr 
                405                 410                 415     


Glu Glu Gln Lys Lys Lys Thr Ile Val Glu Leu Ala Glu Thr Gly Ser 
            420                 425                 430         


Leu Asp Leu Ser Ile Phe Cys Ser Thr Cys Leu Ile Arg Lys Pro Val 
        435                 440                 445             


Arg Ser Lys His Cys Gly Val Cys Asn Arg Cys Ile Ala Lys Phe Asp 
    450                 455                 460                 


His His Cys Pro Trp Val Gly Asn Cys Val Gly Ala Gly Asn His Arg 
465                 470                 475                 480 


Tyr Phe Met Gly Tyr Leu Phe Phe Leu Leu Phe Met Ile Cys Trp Met 
                485                 490                 495     


Ile Tyr Gly Cys Ile Ser Tyr Trp Gly Leu His Cys Glu Thr Thr Tyr 
            500                 505                 510         


Thr Lys Asp Gly Phe Trp Thr Tyr Ile Thr Gln Ile Ala Thr Cys Ser 
        515                 520                 525             


Pro Trp Met Phe Trp Met Phe Leu Asn Ser Val Phe His Phe Met Trp 
    530                 535                 540                 


Val Ala Val Leu Leu Met Cys Gln Met Tyr Gln Ile Ser Cys Leu Gly 
545                 550                 555                 560 


Ile Thr Thr Asn Glu Arg Met Asn Ala Arg Arg Tyr Lys His Phe Lys 
                565                 570                 575     


Val Thr Thr Thr Ser Ile Glu Ser Pro Phe Asn His Gly Cys Val Arg 
            580                 585                 590         


Asn Ile Ile Asp Phe Phe Glu Phe Arg Cys Cys Gly Leu Phe Arg Pro 
        595                 600                 605             


Val Ile Val Asp Trp Thr Arg Gln Tyr Thr Ile Glu Tyr Asp Gln Ile 
    610                 615                 620                 


Ser Gly Ser Gly Tyr Gln Leu Val 
625                 630         


<210>  1003
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  1003

Met Lys Asp Cys Glu Tyr Gln Gln Ile Ser Pro Gly Ala Ala Pro Leu 
1               5                   10                  15      


Pro Ala Ser Pro Gly Ala Arg Arg Pro Gly Pro Ala Ala Ser Pro Thr 
            20                  25                  30          


Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Pro Ala Pro Pro Arg Trp 
        35                  40                  45              


Ser Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Leu Gly Arg 
    50                  55                  60                  


Arg Pro Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Arg Phe Tyr 
65                  70                  75                  80  


Cys Gly Gly Arg Leu Met Leu Ala Gly His Gly Gly Val Phe Ala Leu 
                85                  90                  95      


Thr Leu Leu Leu Ile Leu Thr Thr Thr Gly Leu Phe Phe Val Phe Asp 
            100                 105                 110         


Cys Pro Tyr Leu Ala Arg Lys Leu Thr Leu Ala Ile Pro Ile Ile Ala 
        115                 120                 125             


Ala Ile Leu Phe Phe Phe Val Met Ser Cys Leu Leu Gln Thr Ser Phe 
    130                 135                 140                 


Thr Asp Pro Gly Ile Leu Pro Arg Ala Thr Val Cys Glu Ala Ala Ala 
145                 150                 155                 160 


Leu Glu Lys Gln Ile Asp Asn Thr Gly Ser Ser Thr Tyr Arg Pro Pro 
                165                 170                 175     


Pro Arg Thr Arg Glu Val Leu Ile Asn Gly Gln Met Val Lys Leu Lys 
            180                 185                 190         


Tyr Cys Phe Thr Cys Lys Met Phe Arg Pro Pro Arg Thr Ser His Cys 
        195                 200                 205             


Ser Val Cys Asp Asn Cys Val Glu Arg Phe Asp His His Cys Pro Trp 
    210                 215                 220                 


Val Gly Asn Cys Val Gly Arg Arg Asn Tyr Arg Phe Phe Tyr Ala Phe 
225                 230                 235                 240 


Ile Leu Ser Leu Ser Phe Leu Thr Ala Phe Ile Phe Ala Cys Val Val 
                245                 250                 255     


Thr His Leu Thr Leu Arg Ala Gln Gly Ser Asn Phe Leu Ser Thr Leu 
            260                 265                 270         


Lys Glu Thr Pro Ala Ser Val Leu Glu Leu Val Ile Cys Phe Phe Ser 
        275                 280                 285             


Ile Trp Ser Ile Leu Gly Leu Ser Gly Phe His Thr Tyr Leu Val Ala 
    290                 295                 300                 


Ser Asn Leu Thr Thr Asn Glu Asp Ile Lys Gly Ser Trp Ser Ser Lys 
305                 310                 315                 320 


Arg Gly Gly Glu Ala Ser Val Asn Pro Tyr Ser His Lys Ser Ile Ile 
                325                 330                 335     


Thr Asn Cys Cys Ala Val Leu Cys Gly Pro Leu Pro Pro Ser Leu Ile 
            340                 345                 350         


Asp Arg Arg Gly Phe Val Gln Ser Asp Thr Val Leu Pro Ser Pro Ile 
        355                 360                 365             


Arg Ser Asp Glu Pro Ala Cys Arg Ala Lys Pro Asp Ala Ser Met Val 
    370                 375                 380                 


Gly Gly His Pro 
385             


<210>  1004
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  1004

Met Ala Gln Glu Thr Asn Gln Thr Pro Gly Pro Met Leu Cys Ser Thr 
1               5                   10                  15      


Gly Cys Gly Phe Tyr Gly Asn Pro Arg Thr Asn Gly Met Cys Ser Val 
            20                  25                  30          


Cys Tyr Lys Glu His Leu Gln Arg Gln Gln Asn Ser Gly Arg Met Ser 
        35                  40                  45              


Pro Met Gly Thr Ala Ser Gly Ser Asn Ser Pro Thr Ser Asp Ser Ala 
    50                  55                  60                  


Ser Val Gln Arg Ala Asp Thr Ser Leu Asn Asn Cys Glu Gly Ala Ala 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Lys Ser Arg Asn Val Pro Val Ala Ala Leu Pro 
                85                  90                  95      


Val Thr Gln Gln Met Thr Glu Met Ser Ile Ser Arg Glu Asp Lys Ile 
            100                 105                 110         


Thr Thr Pro Lys Thr Glu Val Ser Glu Pro Val Val Thr Gln Pro Ser 
        115                 120                 125             


Pro Ser Val Ser Gln Pro Ser Thr Ser Gln Ser Glu Glu Lys Ala Pro 
    130                 135                 140                 


Glu Leu Pro Lys Pro Lys Lys Asn Arg Cys Phe Met Cys Arg Lys Lys 
145                 150                 155                 160 


Val Gly Leu Thr Gly Phe Asp Cys Arg Cys Gly Asn Leu Phe Cys Gly 
                165                 170                 175     


Leu His Arg Tyr Ser Asp Lys His Asn Cys Pro Tyr Asp Tyr Lys Ala 
            180                 185                 190         


Glu Ala Ala Ala Lys Ile Arg Lys Glu Asn Pro Val Val Val Ala Glu 
        195                 200                 205             


Lys Ile Gln Arg Ile 
    210             


<210>  1005
<211>  1989
<212>  PRT
<213>  Homo sapiens

<400>  1005

Met Ala Thr Ala Asp Thr Pro Ala Pro Ala Ser Ser Gly Leu Ser Pro 
1               5                   10                  15      


Lys Glu Glu Gly Glu Leu Glu Asp Gly Glu Ile Ser Asp Asp Asp Asn 
            20                  25                  30          


Asn Ser Gln Ile Arg Ser Arg Ser Ser Ser Ser Ser Ser Gly Gly Gly 
        35                  40                  45              


Leu Leu Pro Tyr Pro Arg Arg Arg Pro Pro His Ser Ala Arg Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Gln 
65                  70                  75                  80  


Gln Gln Leu Arg Asn Phe Ser Arg Ser Arg His Ala Ser Glu Arg Gly 
                85                  90                  95      


His Leu Arg Gly Pro Ser Ser Tyr Arg Pro Lys Glu Pro Phe Arg Ser 
            100                 105                 110         


His Pro Pro Ser Val Arg Met Pro Ser Ser Ser Leu Ser Glu Ser Ser 
        115                 120                 125             


Pro Arg Pro Ser Phe Trp Glu Arg Ser His Leu Ala Leu Asp Arg Phe 
    130                 135                 140                 


Arg Phe Arg Gly Arg Pro Tyr Arg Gly Gly Ser Arg Trp Ser Arg Gly 
145                 150                 155                 160 


Arg Gly Val Gly Glu Arg Gly Gly Lys Pro Gly Cys Arg Pro Pro Leu 
                165                 170                 175     


Gly Gly Gly Ala Gly Ser Gly Phe Ser Ser Ser Gln Ser Trp Arg Glu 
            180                 185                 190         


Pro Ser Pro Pro Arg Lys Ser Ser Lys Ser Phe Gly Arg Ser Pro Ser 
        195                 200                 205             


Arg Lys Gln Asn Tyr Ser Ser Lys Asn Glu Asn Cys Val Glu Glu Thr 
    210                 215                 220                 


Phe Glu Asp Leu Leu Leu Lys Tyr Lys Gln Ile Gln Leu Glu Leu Glu 
225                 230                 235                 240 


Cys Ile Asn Lys Asp Glu Lys Leu Ala Leu Ser Ser Lys Glu Glu Asn 
                245                 250                 255     


Val Gln Glu Asp Pro Lys Thr Leu Asn Phe Glu Asp Gln Thr Ser Thr 
            260                 265                 270         


Asp Asn Val Ser Ile Thr Lys Asp Ser Ser Lys Glu Val Ala Pro Glu 
        275                 280                 285             


Glu Lys Thr Gln Val Lys Thr Phe Gln Ala Phe Glu Leu Lys Pro Leu 
    290                 295                 300                 


Arg Gln Lys Leu Thr Leu Pro Gly Asp Lys Asn Arg Leu Lys Lys Val 
305                 310                 315                 320 


Lys Asp Gly Ala Lys Pro Leu Ser Leu Lys Ser Asp Thr Thr Asp Ser 
                325                 330                 335     


Ser Gln Gly Leu Gln Asp Lys Glu Gln Asn Leu Thr Arg Arg Ile Ser 
            340                 345                 350         


Thr Ser Asp Ile Leu Ser Glu Lys Lys Leu Gly Glu Asp Glu Glu Glu 
        355                 360                 365             


Leu Ser Glu Leu Gln Leu Arg Leu Leu Ala Leu Gln Ser Ala Ser Lys 
    370                 375                 380                 


Lys Trp Gln Gln Lys Glu Gln Gln Val Met Lys Glu Ser Lys Glu Lys 
385                 390                 395                 400 


Leu Thr Lys Thr Lys Thr Val Gln Gln Lys Val Lys Thr Ser Thr Lys 
                405                 410                 415     


Thr His Ser Ala Lys Lys Val Ser Thr Thr Ala Lys Gln Ala Leu Arg 
            420                 425                 430         


Lys Gln Gln Thr Lys Ala Trp Lys Lys Leu Gln Gln Gln Lys Glu Gln 
        435                 440                 445             


Glu Arg Gln Lys Glu Glu Asp Gln Arg Lys Gln Ala Glu Glu Glu Glu 
    450                 455                 460                 


Arg Arg Lys Arg Glu Glu Glu Ile Arg Lys Ile Arg Asp Leu Ser Asn 
465                 470                 475                 480 


Gln Glu Glu Gln Tyr Asn Arg Phe Met Lys Leu Val Gly Gly Lys Arg 
                485                 490                 495     


Arg Ser Arg Ser Lys Ser Ser Asp Pro Asp Leu Arg Arg Ser Leu Asp 
            500                 505                 510         


Lys Gln Pro Thr Asp Ser Gly Gly Gly Ile Tyr Gln Tyr Asp Asn Tyr 
        515                 520                 525             


Glu Glu Val Ala Met Asp Thr Asp Ser Glu Thr Ser Ser Pro Ala Pro 
    530                 535                 540                 


Ser Pro Val Gln Pro Pro Phe Phe Ser Glu Cys Ser Leu Gly Tyr Phe 
545                 550                 555                 560 


Ser Pro Ala Pro Ser Leu Ser Leu Pro Pro Pro Pro Gln Val Ser Ser 
                565                 570                 575     


Leu Pro Pro Leu Ser Gln Pro Tyr Val Glu Gly Leu Cys Val Ser Leu 
            580                 585                 590         


Glu Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Glu Asp 
        595                 600                 605             


Pro Glu Gln Pro Pro Lys Pro Pro Phe Ala Asp Glu Glu Glu Glu Glu 
    610                 615                 620                 


Glu Met Leu Leu Arg Glu Glu Leu Leu Lys Ser Leu Ala Asn Lys Arg 
625                 630                 635                 640 


Ala Phe Lys Pro Glu Glu Thr Ser Ser Asn Ser Asp Pro Pro Ser Pro 
                645                 650                 655     


Pro Val Leu Asn Asn Ser His Pro Val Pro Arg Ser Asn Leu Ser Ile 
            660                 665                 670         


Val Ser Ile Asn Thr Val Ser Gln Pro Arg Ile Gln Asn Pro Lys Phe 
        675                 680                 685             


His Arg Gly Pro Arg Leu Pro Arg Thr Val Ile Ser Leu Pro Lys His 
    690                 695                 700                 


Lys Ser Val Val Val Thr Leu Asn Asp Ser Asp Asp Ser Glu Ser Asp 
705                 710                 715                 720 


Gly Glu Ala Ser Lys Ser Thr Asn Ser Val Phe Gly Gly Leu Glu Ser 
                725                 730                 735     


Met Ile Lys Glu Ala Arg Arg Thr Ala Glu Gln Ala Ser Lys Pro Lys 
            740                 745                 750         


Val Pro Pro Lys Ser Glu Lys Glu Asn Asp Pro Leu Arg Thr Pro Glu 
        755                 760                 765             


Ala Leu Pro Glu Glu Lys Lys Ile Glu Tyr Arg Leu Leu Lys Glu Glu 
    770                 775                 780                 


Ile Ala Asn Arg Glu Lys Gln Arg Leu Ile Lys Ser Asp Gln Leu Lys 
785                 790                 795                 800 


Thr Ser Ser Ser Ser Pro Ala Asn Ser Asp Val Glu Ile Asp Gly Ile 
                805                 810                 815     


Gly Arg Ile Ala Met Val Thr Lys Gln Val Thr Asp Ala Glu Ser Lys 
            820                 825                 830         


Leu Lys Lys His Arg Ile Leu Leu Met Lys Asp Glu Ser Val Leu Lys 
        835                 840                 845             


Asn Leu Val Gln Gln Glu Ala Lys Lys Lys Glu Ser Val Arg Asn Ala 
    850                 855                 860                 


Glu Ala Lys Ile Thr Lys Leu Thr Glu Gln Leu Gln Ala Thr Glu Lys 
865                 870                 875                 880 


Ile Leu Asn Val Asn Arg Met Phe Leu Lys Lys Leu Gln Glu Gln Ile 
                885                 890                 895     


His Arg Val Gln Gln Arg Val Thr Ile Lys Lys Ala Leu Thr Leu Lys 
            900                 905                 910         


Tyr Gly Glu Glu Leu Ala Arg Ala Lys Ala Val Ala Ser Lys Glu Ile 
        915                 920                 925             


Gly Lys Arg Lys Leu Glu Gln Asp Arg Phe Gly Pro Asn Lys Met Met 
    930                 935                 940                 


Arg Leu Asp Ser Ser Pro Val Ser Ser Pro Arg Lys His Ser Ala Glu 
945                 950                 955                 960 


Leu Ile Ala Met Glu Lys Arg Arg Leu Gln Lys Leu Glu Tyr Glu Tyr 
                965                 970                 975     


Ala Leu Lys Ile Gln Lys Leu Lys Glu Ala Arg Ala Leu Lys Ala Lys 
            980                 985                 990         


Glu Gln Gln Asn Ile Ser Pro Val  Val Glu Glu Glu Pro  Glu Phe Ser 
        995                 1000                 1005             


Leu Pro  Gln Pro Ser Leu His  Asp Leu Thr Gln Asp  Lys Leu Thr 
    1010                 1015                 1020             


Leu Asp  Thr Glu Glu Asn Asp  Val Asp Asp Glu Ile  Leu Ser Gly 
    1025                 1030                 1035             


Ser Ser  Arg Glu Arg Arg Arg  Ser Phe Leu Glu Ser  Asn Tyr Phe 
    1040                 1045                 1050             


Thr Lys  Pro Asn Leu Lys His  Thr Asp Thr Ala Asn  Lys Glu Cys 
    1055                 1060                 1065             


Ile Asn  Lys Leu Asn Lys Asn  Thr Val Glu Lys Pro  Glu Leu Phe 
    1070                 1075                 1080             


Leu Gly  Leu Lys Ile Gly Glu  Leu Gln Lys Leu Tyr  Ser Lys Ala 
    1085                 1090                 1095             


Asp Ser  Leu Lys Gln Leu Ile  Leu Lys Thr Thr Thr  Gly Ile Thr 
    1100                 1105                 1110             


Glu Lys  Val Leu His Gly Gln  Glu Ile Ser Val Asp  Val Asp Phe 
    1115                 1120                 1125             


Val Thr  Ala Gln Ser Lys Thr  Met Glu Val Lys Pro  Cys Pro Phe 
    1130                 1135                 1140             


Arg Pro  Tyr His Ser Pro Leu  Leu Val Phe Lys Ser  Tyr Arg Phe 
    1145                 1150                 1155             


Ser Pro  Tyr Tyr Arg Thr Lys  Glu Lys Leu Pro Leu  Ser Ser Val 
    1160                 1165                 1170             


Ser Tyr  Ser Asn Met Ile Glu  Pro Asp Gln Cys Phe  Cys Arg Phe 
    1175                 1180                 1185             


Asp Leu  Thr Gly Thr Cys Asn  Asp Asp Asp Cys Gln  Trp Gln His 
    1190                 1195                 1200             


Ile Gln  Asp Tyr Thr Leu Ser  Arg Lys Gln Leu Phe  Gln Asp Ile 
    1205                 1210                 1215             


Leu Ser  Tyr Asn Leu Ser Leu  Ile Gly Cys Ala Glu  Thr Ser Thr 
    1220                 1225                 1230             


Asn Glu  Glu Ile Thr Ala Ser  Ala Glu Lys Tyr Val  Glu Lys Leu 
    1235                 1240                 1245             


Phe Gly  Val Asn Lys Asp Arg  Met Ser Met Asp Gln  Met Ala Val 
    1250                 1255                 1260             


Leu Leu  Val Ser Asn Ile Asn  Glu Ser Lys Gly His  Thr Pro Pro 
    1265                 1270                 1275             


Phe Thr  Thr Tyr Lys Asp Lys  Arg Lys Trp Lys Pro  Lys Phe Trp 
    1280                 1285                 1290             


Arg Lys  Pro Ile Ser Asp Asn  Ser Phe Ser Ser Asp  Glu Glu Gln 
    1295                 1300                 1305             


Ser Thr  Gly Pro Ile Lys Tyr  Ala Phe Gln Pro Glu  Asn Gln Ile 
    1310                 1315                 1320             


Asn Val  Pro Ala Leu Asp Thr  Val Val Thr Pro Asp  Asp Val Arg 
    1325                 1330                 1335             


Tyr Phe  Thr Asn Glu Thr Asp  Asp Ile Ala Asn Leu  Glu Ala Ser 
    1340                 1345                 1350             


Val Leu  Glu Asn Pro Ser His  Val Gln Leu Trp Leu  Lys Leu Ala 
    1355                 1360                 1365             


Tyr Lys  Tyr Leu Asn Gln Asn  Glu Gly Glu Cys Ser  Glu Ser Leu 
    1370                 1375                 1380             


Asp Ser  Ala Leu Asn Val Leu  Ala Arg Ala Leu Glu  Asn Asn Lys 
    1385                 1390                 1395             


Asp Asn  Pro Glu Ile Trp Cys  His Tyr Leu Arg Leu  Phe Ser Lys 
    1400                 1405                 1410             


Arg Gly  Thr Lys Asp Glu Val  Gln Glu Met Cys Glu  Thr Ala Val 
    1415                 1420                 1425             


Glu Tyr  Ala Pro Asp Tyr Gln  Ser Phe Trp Thr Phe  Leu His Leu 
    1430                 1435                 1440             


Glu Ser  Thr Phe Glu Glu Lys  Asp Tyr Val Cys Glu  Arg Met Leu 
    1445                 1450                 1455             


Glu Phe  Leu Met Gly Ala Ala  Lys Gln Glu Thr Ser  Asn Ile Leu 
    1460                 1465                 1470             


Ser Phe  Gln Leu Leu Glu Ala  Leu Leu Phe Arg Val  Gln Leu His 
    1475                 1480                 1485             


Ile Phe  Thr Gly Arg Cys Gln  Ser Ala Leu Ala Ile  Leu Gln Asn 
    1490                 1495                 1500             


Ala Leu  Lys Ser Ala Asn Asp  Gly Ile Val Ala Glu  Tyr Leu Lys 
    1505                 1510                 1515             


Thr Ser  Asp Arg Cys Leu Ala  Trp Leu Ala Tyr Ile  His Leu Ile 
    1520                 1525                 1530             


Glu Phe  Asn Ile Leu Pro Ser  Lys Phe Tyr Asp Pro  Ser Asn Asp 
    1535                 1540                 1545             


Asn Pro  Ser Arg Ile Val Asn  Thr Glu Ser Phe Val  Met Pro Trp 
    1550                 1555                 1560             


Gln Ala  Val Gln Asp Val Lys  Thr Asn Pro Asp Met  Leu Leu Ala 
    1565                 1570                 1575             


Val Phe  Glu Asp Ala Val Lys  Ala Cys Thr Asp Glu  Ser Leu Ala 
    1580                 1585                 1590             


Val Glu  Glu Arg Ile Glu Ala  Cys Leu Pro Leu Tyr  Thr Asn Met 
    1595                 1600                 1605             


Ile Ala  Leu His Gln Leu Leu  Glu Arg Tyr Glu Ala  Ala Met Glu 
    1610                 1615                 1620             


Leu Cys  Lys Ser Leu Leu Glu  Ser Cys Pro Ile Asn  Cys Gln Leu 
    1625                 1630                 1635             


Leu Glu  Ala Leu Val Ala Leu  Tyr Leu Gln Thr Asn  Gln His Asp 
    1640                 1645                 1650             


Lys Ala  Arg Ala Val Trp Leu  Thr Ala Phe Glu Lys  Asn Pro Gln 
    1655                 1660                 1665             


Asn Ala  Glu Val Phe Tyr His  Met Cys Lys Phe Phe  Ile Leu Gln 
    1670                 1675                 1680             


Asn Arg  Gly Asp Asn Leu Leu  Pro Phe Leu Arg Lys  Phe Ile Ala 
    1685                 1690                 1695             


Ser Phe  Phe Lys Pro Gly Phe  Glu Lys Tyr Asn Asn  Leu Asp Leu 
    1700                 1705                 1710             


Phe Arg  Tyr Leu Leu Asn Ile  Pro Gly Pro Ile Asp  Ile Pro Ser 
    1715                 1720                 1725             


Arg Leu  Cys Lys Gly Asn Phe  Asp Asp Asp Met Phe  Asn His Gln 
    1730                 1735                 1740             


Val Pro  Tyr Leu Trp Leu Ile  Tyr Cys Leu Cys His  Pro Leu Gln 
    1745                 1750                 1755             


Ser Ser  Ile Lys Glu Thr Val  Glu Ala Tyr Glu Ala  Ala Leu Gly 
    1760                 1765                 1770             


Val Ala  Met Arg Cys Asp Ile  Val Gln Lys Ile Trp  Met Asp Tyr 
    1775                 1780                 1785             


Leu Val  Phe Ala Asn Asn Arg  Ala Ala Gly Ser Arg  Asn Lys Val 
    1790                 1795                 1800             


Gln Glu  Phe Lys Phe Phe Thr  Asp Leu Val Asn Arg  Cys Leu Val 
    1805                 1810                 1815             


Thr Val  Pro Ala Arg Tyr Pro  Ile Pro Phe Ser Ser  Ala Asp Tyr 
    1820                 1825                 1830             


Trp Ser  Asn Tyr Glu Phe His  Asn Arg Val Ile Phe  Phe Tyr Leu 
    1835                 1840                 1845             


Ser Cys  Val Pro Lys Thr Gln  His Ser Lys Thr Leu  Glu Arg Phe 
    1850                 1855                 1860             


Cys Ser  Val Met Pro Ala Asn  Ser Gly Leu Ala Leu  Arg Leu Leu 
    1865                 1870                 1875             


Gln His  Glu Trp Glu Glu Ser  Asn Val Gln Ile Leu  Lys Leu Gln 
    1880                 1885                 1890             


Ala Lys  Met Phe Thr Tyr Asn  Ile Pro Thr Cys Leu  Ala Thr Trp 
    1895                 1900                 1905             


Lys Ile  Ala Ile Ala Ala Glu  Ile Val Leu Lys Gly  Gln Arg Glu 
    1910                 1915                 1920             


Val His  Arg Leu Tyr Gln Arg  Ala Leu Gln Lys Leu  Pro Leu Cys 
    1925                 1930                 1935             


Ala Ser  Leu Trp Lys Asp Gln  Leu Leu Phe Glu Ala  Ser Glu Gly 
    1940                 1945                 1950             


Gly Lys  Thr Asp Asn Leu Arg  Lys Leu Val Ser Lys  Cys Gln Glu 
    1955                 1960                 1965             


Ile Gly  Val Ser Leu Asn Glu  Leu Leu Asn Leu Asn  Ser Asn Lys 
    1970                 1975                 1980             


Thr Glu  Ser Lys Asn His 
    1985                 


<210>  1006
<211>  1539
<212>  PRT
<213>  Homo sapiens

<400>  1006

Met Asp Ser Tyr Phe Lys Ala Ala Val Ser Asp Leu Asp Lys Leu Leu 
1               5                   10                  15      


Asp Asp Phe Glu Gln Asn Pro Asp Glu Gln Asp Tyr Leu Gln Asp Val 
            20                  25                  30          


Gln Asn Ala Tyr Asp Ser Asn His Cys Ser Val Ser Ser Glu Leu Ala 
        35                  40                  45              


Ser Ser Gln Arg Thr Ser Leu Leu Pro Lys Asp Gln Glu Cys Val Asn 
    50                  55                  60                  


Ser Cys Ala Ser Ser Glu Thr Ser Tyr Gly Thr Asn Glu Ser Ser Leu 
65                  70                  75                  80  


Asn Glu Lys Thr Leu Lys Gly Leu Thr Ser Ile Gln Asn Glu Lys Asn 
                85                  90                  95      


Val Thr Gly Leu Asp Leu Leu Ser Ser Val Asp Gly Gly Thr Ser Asp 
            100                 105                 110         


Glu Ile Gln Pro Leu Tyr Met Gly Arg Cys Ser Lys Pro Ile Cys Asp 
        115                 120                 125             


Leu Ile Ser Asp Met Gly Asn Leu Val His Ala Thr Asn Ser Glu Glu 
    130                 135                 140                 


Asp Ile Lys Lys Leu Leu Pro Asp Asp Phe Lys Ser Asn Ala Asp Ser 
145                 150                 155                 160 


Leu Ile Gly Leu Asp Leu Ser Ser Val Ser Asp Thr Pro Cys Val Ser 
                165                 170                 175     


Ser Thr Asp His Asp Ser Asp Thr Val Arg Glu Gln Gln Asn Asp Ile 
            180                 185                 190         


Ser Ser Glu Leu Gln Asn Arg Glu Ile Gly Gly Ile Lys Glu Leu Gly 
        195                 200                 205             


Ile Lys Val Asp Thr Thr Leu Ser Asp Ser Tyr Asn Tyr Ser Gly Thr 
    210                 215                 220                 


Glu Asn Leu Lys Asp Lys Lys Ile Phe Asn Gln Leu Glu Ser Ile Val 
225                 230                 235                 240 


Asp Phe Asn Met Ser Ser Ala Leu Thr Arg Gln Ser Ser Lys Met Phe 
                245                 250                 255     


His Ala Lys Asp Lys Leu Gln His Lys Ser Gln Pro Cys Gly Leu Leu 
            260                 265                 270         


Lys Asp Val Gly Leu Val Lys Glu Glu Val Asp Val Ala Val Ile Thr 
        275                 280                 285             


Ala Ala Glu Cys Leu Lys Glu Glu Gly Lys Thr Ser Ala Leu Thr Cys 
    290                 295                 300                 


Ser Leu Pro Lys Asn Glu Asp Leu Cys Leu Asn Asp Ser Asn Ser Arg 
305                 310                 315                 320 


Asp Glu Asn Phe Lys Leu Pro Asp Phe Ser Phe Gln Glu Asp Lys Thr 
                325                 330                 335     


Val Ile Lys Gln Ser Ala Gln Glu Asp Ser Lys Ser Leu Asp Leu Lys 
            340                 345                 350         


Asp Asn Asp Val Ile Gln Asp Ser Ser Ser Ala Leu His Val Ser Ser 
        355                 360                 365             


Lys Asp Val Pro Ser Ser Leu Ser Cys Leu Pro Ala Ser Gly Ser Met 
    370                 375                 380                 


Cys Gly Ser Leu Ile Glu Ser Lys Ala Arg Gly Asp Phe Leu Pro Gln 
385                 390                 395                 400 


His Glu His Lys Asp Asn Ile Gln Asp Ala Val Thr Ile His Glu Glu 
                405                 410                 415     


Ile Gln Asn Ser Val Val Leu Gly Gly Glu Pro Phe Lys Glu Asn Asp 
            420                 425                 430         


Leu Leu Lys Gln Glu Lys Cys Lys Ser Ile Leu Leu Gln Ser Leu Ile 
        435                 440                 445             


Glu Gly Met Glu Asp Arg Lys Ile Asp Pro Asp Gln Thr Val Ile Arg 
    450                 455                 460                 


Ala Glu Ser Leu Asp Gly Gly Asp Thr Ser Ser Thr Val Val Glu Ser 
465                 470                 475                 480 


Gln Glu Gly Leu Ser Gly Thr His Val Pro Glu Ser Ser Asp Cys Cys 
                485                 490                 495     


Glu Gly Phe Ile Asn Thr Phe Ser Ser Asn Asp Met Asp Gly Gln Asp 
            500                 505                 510         


Leu Asp Tyr Phe Asn Ile Asp Glu Gly Ala Lys Ser Gly Pro Leu Ile 
        515                 520                 525             


Ser Asp Ala Glu Leu Asp Ala Phe Leu Thr Glu Gln Tyr Leu Gln Thr 
    530                 535                 540                 


Thr Asn Ile Lys Ser Phe Glu Glu Asn Val Asn Asp Ser Lys Ser Gln 
545                 550                 555                 560 


Met Asn Gln Ile Asp Met Lys Gly Leu Asp Asp Gly Asn Ile Asn Asn 
                565                 570                 575     


Ile Tyr Phe Asn Ala Glu Ala Gly Ala Ile Gly Glu Ser His Gly Ile 
            580                 585                 590         


Asn Ile Ile Cys Glu Ile Val Asp Lys Gln Asn Thr Ile Glu Asn Gly 
        595                 600                 605             


Leu Ser Leu Gly Glu Lys Ser Thr Ile Pro Val Gln Gln Gly Leu Pro 
    610                 615                 620                 


Thr Ser Lys Ser Glu Ile Thr Asn Gln Leu Ser Val Ser Asp Ile Asn 
625                 630                 635                 640 


Ser Gln Ser Val Gly Gly Ala Arg Pro Lys Gln Leu Phe Ser Leu Pro 
                645                 650                 655     


Ser Arg Thr Arg Ser Ser Lys Asp Leu Asn Lys Pro Asp Val Pro Asp 
            660                 665                 670         


Thr Ile Glu Ser Glu Pro Ser Thr Ala Asp Thr Val Val Pro Ile Thr 
        675                 680                 685             


Cys Ala Ile Asp Ser Thr Ala Asp Pro Gln Val Ser Phe Asn Ser Asn 
    690                 695                 700                 


Tyr Ile Asp Ile Glu Ser Asn Ser Glu Gly Gly Ser Ser Phe Val Thr 
705                 710                 715                 720 


Ala Asn Glu Asp Ser Val Pro Glu Asn Thr Cys Lys Glu Gly Leu Val 
                725                 730                 735     


Leu Gly Gln Lys Gln Pro Thr Trp Val Pro Asp Ser Glu Ala Pro Asn 
            740                 745                 750         


Cys Met Asn Cys Gln Val Lys Phe Thr Phe Thr Lys Arg Arg His His 
        755                 760                 765             


Cys Arg Ala Cys Gly Lys Val Phe Cys Gly Val Cys Cys Asn Arg Lys 
    770                 775                 780                 


Cys Lys Leu Gln Tyr Leu Glu Lys Glu Ala Arg Val Cys Val Val Cys 
785                 790                 795                 800 


Tyr Glu Thr Ile Ser Lys Ala Gln Ala Phe Glu Arg Met Met Ser Pro 
                805                 810                 815     


Thr Gly Ser Asn Leu Lys Ser Asn His Ser Asp Glu Cys Thr Thr Val 
            820                 825                 830         


Gln Pro Pro Gln Glu Asn Gln Thr Ser Ser Ile Pro Ser Pro Ala Thr 
        835                 840                 845             


Leu Pro Val Ser Ala Leu Lys Gln Pro Gly Val Glu Gly Leu Cys Ser 
    850                 855                 860                 


Lys Glu Gln Lys Arg Val Trp Phe Ala Asp Gly Ile Leu Pro Asn Gly 
865                 870                 875                 880 


Glu Val Ala Asp Thr Thr Lys Leu Ser Ser Gly Ser Lys Arg Cys Ser 
                885                 890                 895     


Glu Asp Phe Ser Pro Leu Ser Pro Asp Val Pro Met Thr Val Asn Thr 
            900                 905                 910         


Val Asp His Ser His Ser Thr Thr Val Glu Lys Pro Asn Asn Glu Thr 
        915                 920                 925             


Gly Asp Ile Thr Arg Asn Glu Ile Ile Gln Ser Pro Ile Ser Gln Val 
    930                 935                 940                 


Pro Ser Val Glu Lys Leu Ser Met Asn Thr Gly Asn Glu Gly Leu Pro 
945                 950                 955                 960 


Thr Ser Gly Ser Phe Thr Leu Asp Asp Asp Val Phe Ala Glu Thr Glu 
                965                 970                 975     


Glu Pro Ser Ser Pro Thr Gly Val Leu Val Asn Ser Asn Leu Pro Ile 
            980                 985                 990         


Ala Ser Ile Ser Asp Tyr Arg Leu  Leu Cys Asp Ile Asn  Lys Tyr Val 
        995                 1000                 1005             


Cys Asn  Lys Ile Ser Leu Leu  Pro Asn Asp Glu Asp  Ser Leu Pro 
    1010                 1015                 1020             


Pro Leu  Leu Val Ala Ser Gly  Glu Lys Gly Ser Val  Pro Val Val 
    1025                 1030                 1035             


Glu Glu  His Pro Ser His Glu  Gln Ile Ile Leu Leu  Leu Glu Gly 
    1040                 1045                 1050             


Glu Ser  Phe His Pro Val Thr  Phe Val Leu Asn Ala  Asn Leu Leu 
    1055                 1060                 1065             


Val Asn  Val Lys Phe Ile Phe  Tyr Ser Ser Asp Lys  Tyr Trp Tyr 
    1070                 1075                 1080             


Phe Ser  Thr Asn Gly Leu His  Gly Leu Gly Gln Ala  Glu Ile Ile 
    1085                 1090                 1095             


Ile Leu  Leu Leu Cys Leu Pro  Asn Glu Asp Thr Ile  Pro Lys Asp 
    1100                 1105                 1110             


Ile Phe  Arg Leu Phe Ile Thr  Ile Tyr Lys Asp Ala  Leu Lys Gly 
    1115                 1120                 1125             


Lys Tyr  Ile Glu Asn Leu Asp  Asn Ile Thr Phe Thr  Glu Ser Phe 
    1130                 1135                 1140             


Leu Ser  Ser Lys Asp His Gly  Gly Phe Leu Phe Ile  Thr Pro Thr 
    1145                 1150                 1155             


Phe Gln  Lys Leu Asp Asp Leu  Ser Leu Pro Ser Asn  Pro Phe Leu 
    1160                 1165                 1170             


Cys Gly  Ile Leu Ile Gln Lys  Leu Glu Ile Pro Trp  Ala Lys Val 
    1175                 1180                 1185             


Phe Pro  Met Arg Leu Met Leu  Arg Leu Gly Ala Glu  Tyr Lys Ala 
    1190                 1195                 1200             


Tyr Pro  Ala Pro Leu Thr Ser  Ile Arg Gly Arg Lys  Pro Leu Phe 
    1205                 1210                 1215             


Gly Glu  Ile Gly His Thr Ile  Met Asn Leu Leu Val  Asp Leu Arg 
    1220                 1225                 1230             


Asn Tyr  Gln Tyr Thr Leu His  Asn Ile Asp Gln Leu  Leu Ile His 
    1235                 1240                 1245             


Met Glu  Met Gly Lys Ser Cys  Ile Lys Ile Pro Arg  Lys Lys Tyr 
    1250                 1255                 1260             


Ser Asp  Val Met Lys Val Leu  Asn Ser Ser Asn Glu  His Val Ile 
    1265                 1270                 1275             


Ser Ile  Gly Ala Ser Phe Ser  Thr Glu Ala Asp Ser  His Leu Val 
    1280                 1285                 1290             


Cys Ile  Gln Asn Asp Gly Ile  Tyr Glu Thr Gln Ala  Asn Ser Ala 
    1295                 1300                 1305             


Thr Gly  His Pro Arg Lys Val  Thr Gly Ala Ser Phe  Val Val Phe 
    1310                 1315                 1320             


Asn Gly  Ala Leu Lys Thr Ser  Ser Gly Phe Leu Ala  Lys Ser Ser 
    1325                 1330                 1335             


Ile Val  Glu Asp Gly Leu Met  Val Gln Ile Thr Pro  Glu Thr Met 
    1340                 1345                 1350             


Asn Gly  Leu Arg Leu Ala Leu  Arg Glu Gln Lys Asp  Phe Lys Ile 
    1355                 1360                 1365             


Thr Cys  Gly Lys Val Asp Ala  Val Asp Leu Arg Glu  Tyr Val Asp 
    1370                 1375                 1380             


Ile Cys  Trp Val Asp Ala Glu  Glu Lys Gly Asn Lys  Gly Val Ile 
    1385                 1390                 1395             


Ser Ser  Val Asp Gly Ile Ser  Leu Gln Gly Phe Pro  Ser Glu Lys 
    1400                 1405                 1410             


Ile Lys  Leu Glu Ala Asp Phe  Glu Thr Asp Glu Lys  Ile Val Lys 
    1415                 1420                 1425             


Cys Thr  Glu Val Phe Tyr Phe  Leu Lys Asp Gln Asp  Leu Ser Ile 
    1430                 1435                 1440             


Leu Ser  Thr Ser Tyr Gln Phe  Ala Lys Glu Ile Ala  Met Ala Cys 
    1445                 1450                 1455             


Ser Ala  Ala Leu Cys Pro His  Leu Lys Thr Leu Lys  Ser Asn Gly 
    1460                 1465                 1470             


Met Asn  Lys Ile Gly Leu Arg  Val Ser Ile Asp Thr  Asp Met Val 
    1475                 1480                 1485             


Glu Phe  Gln Ala Gly Ser Glu  Gly Gln Leu Leu Pro  Gln His Tyr 
    1490                 1495                 1500             


Leu Asn  Asp Leu Asp Ser Ala  Leu Ile Pro Val Ile  His Gly Gly 
    1505                 1510                 1515             


Thr Ser  Asn Ser Ser Leu Pro  Leu Glu Ile Glu Leu  Val Phe Phe 
    1520                 1525                 1530             


Ile Ile  Glu His Leu Phe 
    1535                 


<210>  1007
<211>  1067
<212>  PRT
<213>  Homo sapiens

<400>  1007

Met Asn Ser Met Asp Arg His Ile Gln Gln Thr Asn Asp Arg Leu Gln 
1               5                   10                  15      


Cys Ile Lys Gln His Leu Gln Asn Pro Ala Asn Phe His Asn Ala Ala 
            20                  25                  30          


Thr Glu Leu Leu Asp Trp Cys Gly Asp Pro Arg Ala Phe Gln Arg Pro 
        35                  40                  45              


Phe Glu Gln Ser Leu Met Gly Cys Leu Thr Val Val Ser Arg Val Ala 
    50                  55                  60                  


Ala Gln Gln Gly Phe Asp Leu Asp Leu Gly Tyr Arg Leu Leu Ala Val 
65                  70                  75                  80  


Cys Ala Ala Asn Arg Asp Lys Phe Thr Pro Lys Ser Ala Ala Leu Leu 
                85                  90                  95      


Ser Ser Trp Cys Glu Glu Leu Gly Arg Leu Leu Leu Leu Arg His Gln 
            100                 105                 110         


Lys Ser Arg Gln Ser Asp Pro Pro Gly Lys Leu Pro Met Gln Pro Pro 
        115                 120                 125             


Leu Ser Ser Met Ser Ser Met Lys Pro Thr Leu Ser His Ser Asp Gly 
    130                 135                 140                 


Ser Phe Pro Tyr Asp Ser Val Pro Trp Gln Gln Asn Thr Asn Gln Pro 
145                 150                 155                 160 


Pro Gly Ser Leu Ser Val Val Thr Thr Val Trp Gly Val Thr Asn Thr 
                165                 170                 175     


Ser Gln Ser Gln Val Leu Gly Asn Pro Met Ala Asn Ala Asn Asn Pro 
            180                 185                 190         


Met Asn Pro Gly Gly Asn Pro Met Ala Ser Gly Met Thr Thr Ser Asn 
        195                 200                 205             


Pro Gly Leu Asn Ser Pro Gln Phe Ala Gly Gln Gln Gln Gln Phe Ser 
    210                 215                 220                 


Ala Lys Ala Gly Pro Ala Gln Pro Tyr Ile Gln Gln Ser Met Tyr Gly 
225                 230                 235                 240 


Arg Pro Asn Tyr Pro Gly Ser Gly Gly Phe Gly Ala Ser Tyr Pro Gly 
                245                 250                 255     


Gly Pro Asn Ala Pro Ala Gly Met Gly Ile Pro Pro His Thr Arg Pro 
            260                 265                 270         


Pro Ala Asp Phe Thr Gln Pro Ala Ala Ala Ala Ala Ala Ala Ala Val 
        275                 280                 285             


Ala Ala Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr Val Ala 
    290                 295                 300                 


Ala Leu Gln Glu Thr Gln Asn Lys Asp Ile Asn Gln Tyr Gly Pro Met 
305                 310                 315                 320 


Gly Pro Thr Gln Ala Tyr Asn Ser Gln Phe Met Asn Gln Pro Gly Pro 
                325                 330                 335     


Arg Gly Pro Ala Ser Met Gly Gly Ser Met Asn Pro Ala Ser Met Ala 
            340                 345                 350         


Ala Gly Met Thr Pro Ser Gly Met Ser Gly Pro Pro Met Gly Met Asn 
        355                 360                 365             


Gln Pro Arg Pro Pro Gly Ile Ser Pro Phe Gly Thr His Gly Gln Arg 
    370                 375                 380                 


Met Pro Gln Gln Thr Tyr Pro Gly Pro Arg Pro Gln Ser Leu Pro Ile 
385                 390                 395                 400 


Gln Asn Ile Lys Arg Pro Tyr Pro Gly Glu Pro Asn Tyr Gly Asn Gln 
                405                 410                 415     


Gln Tyr Gly Pro Asn Ser Gln Phe Pro Thr Gln Pro Gly Gln Tyr Pro 
            420                 425                 430         


Ala Pro Asn Pro Pro Arg Pro Leu Thr Ser Pro Asn Tyr Pro Gly Gln 
        435                 440                 445             


Arg Met Pro Ser Gln Pro Ser Ser Gly Gln Tyr Pro Pro Pro Thr Val 
    450                 455                 460                 


Asn Met Gly Gln Tyr Tyr Lys Pro Glu Gln Phe Asn Gly Gln Asn Asn 
465                 470                 475                 480 


Thr Phe Ser Gly Ser Ser Tyr Ser Asn Tyr Ser Gln Gly Asn Val Asn 
                485                 490                 495     


Arg Pro Pro Arg Pro Val Pro Val Ala Asn Tyr Pro His Ser Pro Val 
            500                 505                 510         


Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Gly Ser Ser Ile Pro Pro 
        515                 520                 525             


Tyr Leu Ser Pro Ser Gln Asp Val Lys Pro Pro Phe Pro Pro Asp Ile 
    530                 535                 540                 


Lys Pro Asn Met Ser Ala Leu Pro Pro Pro Pro Ala Asn His Asn Asp 
545                 550                 555                 560 


Glu Leu Arg Leu Thr Phe Pro Val Arg Asp Gly Val Val Leu Glu Pro 
                565                 570                 575     


Phe Arg Leu Glu His Asn Leu Ala Val Ser Asn His Val Phe His Leu 
            580                 585                 590         


Arg Pro Thr Val His Gln Thr Leu Met Trp Arg Ser Asp Leu Glu Leu 
        595                 600                 605             


Gln Phe Lys Cys Tyr His His Glu Asp Arg Gln Met Asn Thr Asn Trp 
    610                 615                 620                 


Pro Ala Ser Val Gln Val Ser Val Asn Ala Thr Pro Leu Thr Ile Glu 
625                 630                 635                 640 


Arg Gly Asp Asn Lys Thr Ser His Lys Pro Leu His Leu Lys His Val 
                645                 650                 655     


Cys Gln Pro Gly Arg Asn Thr Ile Gln Ile Thr Val Thr Ala Cys Cys 
            660                 665                 670         


Cys Ser His Leu Phe Val Leu Gln Leu Val His Arg Pro Ser Val Arg 
        675                 680                 685             


Ser Val Leu Gln Gly Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu His 
    690                 695                 700                 


Cys Ile Thr Lys Ile Lys Arg Asn Phe Ser Ser Val Ala Ala Ser Ser 
705                 710                 715                 720 


Gly Asn Thr Thr Leu Asn Gly Glu Asp Gly Val Glu Gln Thr Ala Ile 
                725                 730                 735     


Lys Val Ser Leu Lys Cys Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro 
            740                 745                 750         


Ala Arg Gly His Asp Cys Lys His Val Gln Cys Phe Asp Leu Glu Ser 
        755                 760                 765             


Tyr Leu Gln Leu Asn Cys Glu Arg Gly Thr Trp Arg Cys Pro Val Cys 
    770                 775                 780                 


Asn Lys Thr Ala Leu Leu Glu Gly Leu Glu Val Asp Gln Tyr Met Trp 
785                 790                 795                 800 


Gly Ile Leu Asn Ala Ile Gln His Ser Glu Phe Glu Glu Val Thr Ile 
                805                 810                 815     


Asp Pro Thr Cys Ser Trp Arg Pro Val Pro Ile Lys Ser Asp Leu His 
            820                 825                 830         


Ile Lys Asp Asp Pro Asp Gly Ile Pro Ser Lys Arg Phe Lys Thr Met 
        835                 840                 845             


Ser Pro Ser Gln Met Ile Met Pro Asn Val Met Glu Met Ile Ala Ala 
    850                 855                 860                 


Leu Gly Pro Gly Pro Ser Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly 
865                 870                 875                 880 


Thr Asn Ser Asn Asp Tyr Ser Ser Gln Gly Asn Asn Tyr Gln Gly His 
                885                 890                 895     


Gly Asn Phe Asp Phe Pro His Gly Asn Pro Gly Gly Thr Ser Met Asn 
            900                 905                 910         


Asp Phe Met His Gly Pro Pro Gln Leu Ser His Pro Pro Asp Met Pro 
        915                 920                 925             


Asn Asn Met Ala Ala Leu Glu Lys Pro Leu Ser His Pro Met Gln Glu 
    930                 935                 940                 


Thr Met Pro His Ala Gly Ser Ser Asp Gln Pro His Pro Ser Ile Gln 
945                 950                 955                 960 


Gln Gly Leu His Val Pro His Pro Ser Ser Gln Ser Gly Pro Pro Leu 
                965                 970                 975     


His His Ser Gly Ala Pro Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln 
            980                 985                 990         


Pro Pro Gln Ala Ala Pro Ser Ser  His Pro His Ser Asp  Leu Thr Phe 
        995                 1000                 1005             


Asn Pro  Ser Ser Ala Leu Glu  Gly Gln Ala Gly Ala  Gln Gly Ala 
    1010                 1015                 1020             


Ser Asp  Met Pro Glu Pro Ser  Leu Asp Leu Leu Pro  Glu Leu Thr 
    1025                 1030                 1035             


Asn Pro  Asp Glu Leu Leu Ser  Tyr Leu Asp Pro Pro  Asp Leu Pro 
    1040                 1045                 1050             


Ser Asn  Ser Asn Asp Asp Leu  Leu Ser Leu Phe Glu  Asn Asn 
    1055                 1060                 1065         


<210>  1008
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  1008

Met Leu Leu Ala Gln Ile Asn Arg Asp Ser Gln Gly Met Thr Glu Phe 
1               5                   10                  15      


Pro Gly Gly Gly Met Glu Ala Gln His Val Thr Leu Cys Leu Thr Glu 
            20                  25                  30          


Ala Val Thr Val Ala Asp Gly Asp Asn Leu Glu Asn Met Glu Gly Val 
        35                  40                  45              


Ser Leu Gln Ala Val Thr Leu Ala Asp Gly Ser Thr Ala Tyr Ile Gln 
    50                  55                  60                  


His Asn Ser Lys Asp Ala Lys Leu Ile Asp Gly Gln Val Ile Gln Leu 
65                  70                  75                  80  


Glu Asp Gly Ser Ala Ala Tyr Val Gln His Val Pro Ile Pro Lys Ser 
                85                  90                  95      


Thr Gly Asp Ser Leu Arg Leu Glu Asp Gly Gln Ala Val Gln Leu Glu 
            100                 105                 110         


Asp Gly Thr Thr Ala Phe Ile His His Thr Ser Lys Asp Ser Tyr Asp 
        115                 120                 125             


Gln Ser Ala Leu Gln Ala Val Gln Leu Glu Asp Gly Thr Thr Ala Tyr 
    130                 135                 140                 


Ile His His Ala Val Gln Val Pro Gln Ser Asp Thr Ile Leu Ala Ile 
145                 150                 155                 160 


Gln Ala Asp Gly Thr Val Ala Gly Leu His Thr Gly Asp Ala Thr Ile 
                165                 170                 175     


Asp Pro Asp Thr Ile Ser Ala Leu Glu Gln Tyr Ala Ala Lys Val Ser 
            180                 185                 190         


Ile Asp Gly Ser Glu Ser Val Ala Gly Thr Gly Met Ile Gly Glu Asn 
        195                 200                 205             


Glu Gln Glu Lys Lys Met Gln Ile Val Leu Gln Gly His Ala Thr Arg 
    210                 215                 220                 


Val Thr Ala Lys Ser Gln Gln Ser Gly Glu Lys Ala Phe Arg Cys Glu 
225                 230                 235                 240 


Tyr Asp Gly Cys Gly Lys Leu Tyr Thr Thr Ala His His Leu Lys Val 
                245                 250                 255     


His Glu Arg Ser His Thr Gly Asp Arg Pro Tyr Gln Cys Glu His Ala 
            260                 265                 270         


Gly Cys Gly Lys Ala Phe Ala Thr Gly Tyr Gly Leu Lys Ser His Val 
        275                 280                 285             


Arg Thr His Thr Gly Glu Lys Pro Tyr Arg Cys Ser Glu Asp Asn Cys 
    290                 295                 300                 


Thr Lys Ser Phe Lys Thr Ser Gly Asp Leu Gln Lys His Ile Arg Thr 
305                 310                 315                 320 


His Thr Gly Glu Arg Pro Phe Lys Cys Pro Phe Glu Gly Cys Gly Arg 
                325                 330                 335     


Ser Phe Thr Thr Ser Asn Ile Arg Lys Val His Val Arg Thr His Thr 
            340                 345                 350         


Gly Glu Arg Pro Tyr Tyr Cys Thr Glu Pro Gly Cys Gly Arg Ala Phe 
        355                 360                 365             


Ala Ser Ala Thr Asn Tyr Lys Asn His Val Arg Ile His Thr Gly Glu 
    370                 375                 380                 


Lys Pro Tyr Val Cys Thr Val Pro Gly Cys Asp Lys Arg Phe Thr Glu 
385                 390                 395                 400 


Tyr Ser Ser Leu Tyr Lys His His Val Val His Thr His Ser Lys Pro 
                405                 410                 415     


Tyr Asn Cys Asn His Cys Gly Lys Thr Tyr Lys Gln Ile Ser Thr Leu 
            420                 425                 430         


Ala Met His Lys Arg Thr Ala His Asn Asp Thr Glu Pro Ile Glu Glu 
        435                 440                 445             


Glu Gln Glu Ala Phe Phe Glu Pro Pro Pro Gly Gln Gly Glu Asp Val 
    450                 455                 460                 


Leu Lys Gly Ser Gln Ile Thr Tyr Val Thr Gly Val Glu Gly Asp Asp 
465                 470                 475                 480 


Val Val Ser Thr Gln Val Ala Thr Val Thr Gln Ser Gly Leu Ser Gln 
                485                 490                 495     


Gln Val Thr Leu Ile Ser Gln Asp Gly Thr Gln His Val Asn Ile Ser 
            500                 505                 510         


Gln Ala Asp Met Gln Ala Ile Gly Asn Thr Ile Thr Met Val Thr Gln 
        515                 520                 525             


Asp Gly Thr Pro Ile Thr Val Pro Ala His Asp Ala Val Ile Ser Ser 
    530                 535                 540                 


Ala Gly Thr His Ser Val Ala Met Val Thr Ala Glu Gly Thr Glu Gly 
545                 550                 555                 560 


Glu Gln Val Ala Ile Val Ala Gln Asp Leu Ala Ala Phe His Thr Ala 
                565                 570                 575     


Ser Ser Glu Met Gly His Gln Gln His Ser His His Leu Val Thr Thr 
            580                 585                 590         


Glu Thr Arg Pro Leu Thr Leu Val Ala Thr Ser Asn Gly Thr Gln Ile 
        595                 600                 605             


Ala Val Gln Leu Gly Glu Gln Pro Ser Leu Glu Glu Ala Ile Arg Ile 
    610                 615                 620                 


Ala Ser Arg Ile Gln Gln Gly Glu Thr Pro Gly Leu Asp Asp 
625                 630                 635             


<210>  1009
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1009

Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 


<210>  1010
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  1010

Met Asn Ile Glu Val Val Glu Val Leu Thr Leu Asn Gln Glu Val Ala 
1               5                   10                  15      


Gly Pro Arg Asn Ala Gln Ile Gln Ala Leu Tyr Ala Glu Asp Gly Ser 
            20                  25                  30          


Leu Ser Ala Asp Ala Pro Ser Glu Gln Val Gln Gln Gln Gly Lys His 
        35                  40                  45              


Pro Gly Asp Pro Glu Ala Ala Arg Gln Arg Phe Arg Gln Phe Arg Tyr 
    50                  55                  60                  


Lys Asp Met Thr Gly Pro Arg Glu Ala Leu Asp Gln Leu Arg Glu Leu 
65                  70                  75                  80  


Cys His Gln Trp Leu Gln Pro Lys Ala Arg Ser Lys Glu Gln Ile Leu 
                85                  90                  95      


Glu Leu Leu Val Leu Glu Gln Phe Leu Gly Ala Leu Pro Val Lys Leu 
            100                 105                 110         


Arg Thr Trp Val Glu Ser Gln His Pro Glu Asn Cys Gln Glu Val Val 
        115                 120                 125             


Ala Leu Val Glu Gly Val Thr Trp Met Ser Glu Glu Glu Val Leu Pro 
    130                 135                 140                 


Ala Gly Gln Pro Ala Glu Gly Thr Thr Cys Cys Leu Glu Val Thr Ala 
145                 150                 155                 160 


Gln Gln Glu Glu Lys Gln Glu Asp Ala Ala Ile Cys Pro Val Thr Val 
                165                 170                 175     


Leu Pro Glu Glu Pro Val Thr Phe Gln Asp Val Ala Val Asp Phe Ser 
            180                 185                 190         


Arg Glu Glu Trp Gly Leu Leu Gly Pro Thr Gln Arg Thr Glu Tyr Arg 
        195                 200                 205             


Asp Val Met Leu Glu Thr Phe Gly His Leu Val Ser Val Gly Trp Glu 
    210                 215                 220                 


Thr Thr Leu Glu Asn Lys Glu Leu Ala Pro Asn Ser Asp Ile Pro Glu 
225                 230                 235                 240 


Glu Glu Pro Ala Pro Ser Leu Lys Val Gln Glu Ser Ser Arg Asp Cys 
                245                 250                 255     


Ala Leu Ser Ser Thr Leu Glu Asp Thr Leu Gln Gly Gly Val Gln Glu 
            260                 265                 270         


Val Gln Asp Thr Val Leu Lys Gln Met Glu Ser Ala Gln Glu Lys Asp 
        275                 280                 285             


Leu Pro Gln Lys Lys His Phe Asp Asn Arg Glu Ser Gln Ala Asn Ser 
    290                 295                 300                 


Gly Ala Leu Asp Thr Asn Gln Val Ser Leu Gln Lys Ile Asp Asn Pro 
305                 310                 315                 320 


Glu Ser Gln Ala Asn Ser Gly Ala Leu Asp Thr Asn Gln Val Leu Leu 
                325                 330                 335     


His Lys Ile Pro Pro Arg Lys Arg Leu Arg Lys Arg Asp Ser Gln Val 
            340                 345                 350         


Lys Ser Met Lys His Asn Ser Arg Val Lys Ile His Gln Lys Ser Cys 
        355                 360                 365             


Glu Arg Gln Lys Ala Lys Glu Gly Asn Gly Cys Arg Lys Thr Phe Ser 
    370                 375                 380                 


Arg Ser Thr Lys Gln Ile Thr Phe Ile Arg Ile His Lys Gly Ser Gln 
385                 390                 395                 400 


Val Cys Arg Cys Ser Glu Cys Gly Lys Ile Phe Arg Asn Pro Arg Tyr 
                405                 410                 415     


Phe Ser Val His Lys Lys Ile His Thr Gly Glu Arg Pro Tyr Val Cys 
            420                 425                 430         


Gln Asp Cys Gly Lys Gly Phe Val Gln Ser Ser Ser Leu Thr Gln His 
        435                 440                 445             


Gln Arg Val His Ser Gly Glu Arg Pro Phe Glu Cys Gln Glu Cys Gly 
    450                 455                 460                 


Arg Thr Phe Asn Asp Arg Ser Ala Ile Ser Gln His Leu Arg Thr His 
465                 470                 475                 480 


Thr Gly Ala Lys Pro Tyr Lys Cys Gln Asp Cys Gly Lys Ala Phe Arg 
                485                 490                 495     


Gln Ser Ser His Leu Ile Arg His Gln Arg Thr His Thr Gly Glu Arg 
            500                 505                 510         


Pro Tyr Ala Cys Asn Lys Cys Gly Lys Ala Phe Thr Gln Ser Ser His 
        515                 520                 525             


Leu Ile Gly His Gln Arg Thr His Asn Arg Thr Lys Arg Lys Lys Lys 
    530                 535                 540                 


Gln Pro Thr Ser 
545             


<210>  1011
<211>  2723
<212>  PRT
<213>  Homo sapiens

<400>  1011

Met Ala Asp Glu Glu Ala Glu Gln Glu Arg Leu Ser Cys Gly Glu Gly 
1               5                   10                  15      


Gly Cys Val Ala Glu Leu Gln Arg Leu Gly Glu Arg Leu Gln Glu Leu 
            20                  25                  30          


Glu Leu Gln Leu Arg Glu Ser Arg Val Pro Ala Val Glu Ala Ala Thr 
        35                  40                  45              


Asp Tyr Cys Gln Gln Leu Cys Gln Thr Leu Leu Glu Tyr Ala Glu Lys 
    50                  55                  60                  


Trp Lys Thr Ser Glu Asp Pro Leu Pro Leu Leu Glu Val Tyr Thr Val 
65                  70                  75                  80  


Ala Ile Gln Ser Tyr Val Lys Ala Arg Pro Tyr Leu Thr Ser Glu Cys 
                85                  90                  95      


Glu Asn Val Ala Leu Val Leu Glu Arg Leu Ala Leu Ser Cys Val Glu 
            100                 105                 110         


Leu Leu Leu Cys Leu Pro Val Glu Leu Ser Asp Lys Gln Trp Glu Gln 
        115                 120                 125             


Phe Gln Thr Leu Val Gln Val Ala His Glu Lys Leu Met Glu Asn Gly 
    130                 135                 140                 


Ser Cys Glu Leu His Phe Leu Ala Thr Leu Ala Gln Glu Thr Gly Val 
145                 150                 155                 160 


Trp Lys Asn Pro Val Leu Cys Thr Ile Leu Ser Gln Glu Pro Leu Asp 
                165                 170                 175     


Lys Asp Lys Val Asn Glu Phe Leu Ala Phe Glu Gly Pro Ile Leu Leu 
            180                 185                 190         


Asp Met Arg Ile Lys His Leu Ile Lys Thr Asn Gln Leu Ser Gln Ala 
        195                 200                 205             


Thr Ala Leu Ala Lys Leu Cys Ser Asp His Pro Glu Ile Gly Ile Lys 
    210                 215                 220                 


Gly Ser Phe Lys Gln Thr Tyr Leu Val Cys Leu Cys Thr Ser Ser Pro 
225                 230                 235                 240 


Asn Gly Lys Leu Ile Glu Glu Ile Ser Glu Val Asp Cys Lys Asp Ala 
                245                 250                 255     


Leu Glu Met Ile Cys Asn Leu Glu Ser Glu Gly Asp Glu Lys Ser Ala 
            260                 265                 270         


Leu Val Leu Cys Thr Ala Phe Leu Ser Arg Gln Leu Gln Gln Gly Asp 
        275                 280                 285             


Met Tyr Cys Ala Trp Glu Leu Thr Leu Phe Trp Ser Lys Leu Gln Gln 
    290                 295                 300                 


Arg Val Glu Pro Ser Ile Gln Val Tyr Leu Glu Arg Cys Arg Gln Leu 
305                 310                 315                 320 


Ser Leu Leu Thr Lys Thr Val Tyr His Ile Phe Phe Leu Ile Lys Val 
                325                 330                 335     


Ile Asn Ser Glu Thr Glu Gly Ala Gly Leu Ala Thr Cys Ile Glu Leu 
            340                 345                 350         


Cys Val Lys Ala Leu Arg Leu Glu Ser Thr Glu Asn Thr Glu Val Lys 
        355                 360                 365             


Ile Ser Ile Cys Lys Thr Ile Ser Cys Leu Leu Pro Asp Asp Leu Glu 
    370                 375                 380                 


Val Lys Arg Ala Cys Gln Leu Ser Glu Phe Leu Ile Glu Pro Thr Val 
385                 390                 395                 400 


Asp Ala Tyr Tyr Ala Val Glu Met Leu Tyr Asn Gln Pro Asp Gln Lys 
                405                 410                 415     


Tyr Asp Glu Glu Asn Leu Pro Ile Pro Asn Ser Leu Arg Cys Glu Leu 
            420                 425                 430         


Leu Leu Val Leu Lys Thr Gln Trp Pro Phe Asp Pro Glu Phe Trp Asp 
        435                 440                 445             


Trp Lys Thr Leu Lys Arg Gln Cys Leu Ala Leu Met Gly Glu Glu Ala 
    450                 455                 460                 


Ser Ile Val Ser Ser Ile Asp Glu Leu Asn Asp Ser Glu Val Tyr Glu 
465                 470                 475                 480 


Lys Val Val Asp Tyr Gln Glu Glu Ser Lys Glu Thr Ser Met Asn Gly 
                485                 490                 495     


Leu Ser Gly Gly Val Gly Ala Asn Ser Gly Leu Leu Lys Asp Ile Gly 
            500                 505                 510         


Asp Glu Lys Gln Lys Lys Arg Glu Ile Lys Gln Leu Arg Glu Arg Gly 
        515                 520                 525             


Phe Ile Ser Ala Arg Phe Arg Asn Trp Gln Ala Tyr Met Gln Tyr Cys 
    530                 535                 540                 


Val Leu Cys Asp Lys Glu Phe Leu Gly His Arg Ile Val Arg His Ala 
545                 550                 555                 560 


Gln Lys His Tyr Lys Asp Gly Ile Tyr Ser Cys Pro Ile Cys Ala Lys 
                565                 570                 575     


Asn Phe Asn Ser Lys Glu Thr Phe Val Pro His Val Thr Leu His Val 
            580                 585                 590         


Lys Gln Ser Ser Lys Glu Arg Leu Ala Ala Met Lys Pro Leu Arg Arg 
        595                 600                 605             


Leu Gly Arg Pro Pro Lys Ile Thr Thr Thr Asn Glu Asn Gln Lys Thr 
    610                 615                 620                 


Asn Thr Val Ala Lys Gln Glu Gln Arg Pro Ile Lys Lys Asn Ser Leu 
625                 630                 635                 640 


Tyr Ser Thr Asp Phe Ile Val Phe Asn Asp Asn Asp Gly Ser Asp Asp 
                645                 650                 655     


Glu Asn Asp Asp Lys Asp Lys Ser Tyr Glu Pro Glu Val Ile Pro Val 
            660                 665                 670         


Gln Lys Pro Val Pro Val Asn Glu Phe Asn Cys Pro Val Thr Phe Cys 
        675                 680                 685             


Lys Lys Gly Phe Lys Tyr Phe Lys Asn Leu Ile Ala His Val Lys Gly 
    690                 695                 700                 


His Lys Asp Asn Glu Asp Ala Lys Arg Phe Leu Glu Met Gln Ser Lys 
705                 710                 715                 720 


Lys Val Ile Cys Gln Tyr Cys Arg Arg His Phe Val Ser Val Thr His 
                725                 730                 735     


Leu Asn Asp His Leu Gln Met His Cys Gly Ser Lys Pro Tyr Ile Cys 
            740                 745                 750         


Ile Gln Met Lys Cys Lys Ala Gly Phe Asn Ser Tyr Ala Glu Leu Leu 
        755                 760                 765             


Thr His Arg Lys Glu His Gln Val Phe Arg Ala Lys Cys Met Phe Pro 
    770                 775                 780                 


Lys Cys Gly Arg Ile Phe Ser Glu Ala Tyr Leu Leu Tyr Asp His Glu 
785                 790                 795                 800 


Ala Gln His Tyr Asn Thr Tyr Thr Cys Lys Phe Thr Gly Cys Gly Lys 
                805                 810                 815     


Val Tyr Arg Ser Gln Gly Glu Leu Glu Lys His Leu Asp Asp His Ser 
            820                 825                 830         


Thr Pro Pro Glu Lys Val Leu Pro Pro Glu Ala Gln Leu Asn Ser Ser 
        835                 840                 845             


Gly Asp Ser Ile Gln Pro Ser Glu Val Asn Gln Asn Thr Ala Glu Asn 
    850                 855                 860                 


Ile Glu Lys Glu Arg Ser Met Leu Pro Ser Glu Asn Asn Ile Glu Asn 
865                 870                 875                 880 


Ser Leu Leu Ala Asp Arg Ser Asp Ala Trp Asp Lys Ser Lys Ala Glu 
                885                 890                 895     


Ser Ala Val Thr Lys Gln Asp Gln Ile Ser Ala Ser Glu Leu Arg Gln 
            900                 905                 910         


Ala Asn Gly Pro Leu Ser Asn Gly Leu Glu Asn Pro Ala Thr Thr Pro 
        915                 920                 925             


Leu Leu Gln Ser Ser Glu Val Ala Val Ser Ile Lys Val Ser Leu Asn 
    930                 935                 940                 


Gln Gly Ile Glu Asp Asn Phe Gly Lys Gln Glu Asn Ser Thr Val Glu 
945                 950                 955                 960 


Gly Ser Gly Glu Ala Leu Val Thr Asp Leu His Thr Pro Val Glu Asp 
                965                 970                 975     


Thr Cys Asn Asp Leu Cys His Pro Gly Phe Gln Glu Arg Lys Glu Gln 
            980                 985                 990         


Asp Cys Phe Asn Asp Ala His Val  Thr Gln Asn Ser Leu  Val Asn Ser 
        995                 1000                 1005             


Glu Thr  Leu Lys Ile Gly Asp  Leu Thr Pro Gln Asn  Leu Glu Arg 
    1010                 1015                 1020             


Gln Val  Asn Asn Leu Met Thr  Phe Ser Val Gln Asn  Gln Ala Ala 
    1025                 1030                 1035             


Phe Gln  Asn Asn Leu Pro Thr  Ser Lys Phe Glu Cys  Gly Asp Asn 
    1040                 1045                 1050             


Val Lys  Thr Ser Ser Asn Leu  Tyr Asn Leu Pro Leu  Lys Thr Leu 
    1055                 1060                 1065             


Glu Ser  Ile Ala Phe Val Pro  Pro Gln Ser Asp Leu  Ser Asn Ser 
    1070                 1075                 1080             


Leu Gly  Thr Pro Ser Val Pro  Pro Lys Ala Pro Val  Gln Lys Phe 
    1085                 1090                 1095             


Ser Cys  Gln Val Glu Gly Cys  Thr Arg Thr Tyr Asn  Ser Ser Gln 
    1100                 1105                 1110             


Ser Ile  Gly Lys His Met Lys  Thr Ala His Pro Asp  Gln Tyr Ala 
    1115                 1120                 1125             


Ala Phe  Lys Met Gln Arg Lys  Ser Lys Lys Gly Gln  Lys Ala Asn 
    1130                 1135                 1140             


Asn Leu  Asn Thr Pro Asn Asn  Gly Lys Phe Val Tyr  Phe Leu Pro 
    1145                 1150                 1155             


Ser Pro  Val Asn Ser Ser Asn  Pro Phe Phe Thr Ser  Gln Thr Lys 
    1160                 1165                 1170             


Ala Asn  Gly Asn Pro Ala Cys  Ser Ala Gln Leu Gln  His Val Ser 
    1175                 1180                 1185             


Pro Pro  Ile Phe Pro Ala His  Leu Ala Ser Val Ser  Thr Pro Leu 
    1190                 1195                 1200             


Leu Ser  Ser Met Glu Ser Val  Ile Asn Pro Asn Ile  Thr Ser Gln 
    1205                 1210                 1215             


Asp Lys  Asn Glu Gln Gly Gly  Met Leu Cys Ser Gln  Met Glu Asn 
    1220                 1225                 1230             


Leu Pro  Ser Thr Ala Leu Pro  Ala Gln Met Glu Asp  Leu Thr Lys 
    1235                 1240                 1245             


Thr Val  Leu Pro Leu Asn Ile  Asp Ser Gly Ser Asp  Pro Phe Leu 
    1250                 1255                 1260             


Pro Leu  Pro Ala Glu Ser Ser  Ser Met Ser Leu Phe  Pro Ser Pro 
    1265                 1270                 1275             


Ala Asp  Ser Gly Thr Asn Ser  Val Phe Ser Gln Leu  Glu Asn Asn 
    1280                 1285                 1290             


Thr Asn  His Tyr Ser Ser Gln  Ile Glu Gly Asn Thr  Asn Ser Ser 
    1295                 1300                 1305             


Phe Leu  Lys Gly Gly Asn Gly  Glu Asn Ala Val Phe  Pro Ser Gln 
    1310                 1315                 1320             


Val Asn  Val Ala Asn Asn Phe  Ser Ser Thr Asn Ala  Gln Gln Ser 
    1325                 1330                 1335             


Ala Pro  Glu Lys Val Lys Lys  Asp Arg Gly Arg Gly  Pro Asn Gly 
    1340                 1345                 1350             


Lys Glu  Arg Lys Pro Lys His  Asn Lys Arg Ala Lys  Trp Pro Ala 
    1355                 1360                 1365             


Ile Ile  Arg Asp Gly Lys Phe  Ile Cys Ser Arg Cys  Tyr Arg Ala 
    1370                 1375                 1380             


Phe Thr  Asn Pro Arg Ser Leu  Gly Gly His Leu Ser  Lys Arg Ser 
    1385                 1390                 1395             


Tyr Cys  Lys Pro Leu Asp Gly  Ala Glu Ile Ala Gln  Glu Leu Leu 
    1400                 1405                 1410             


Gln Ser  Asn Gly Gln Pro Ser  Leu Leu Ala Ser Met  Ile Leu Ser 
    1415                 1420                 1425             


Thr Asn  Ala Val Asn Leu Gln  Gln Pro Gln Gln Ser  Thr Phe Asn 
    1430                 1435                 1440             


Pro Glu  Ala Cys Phe Lys Asp  Pro Ser Phe Leu Gln  Leu Leu Ala 
    1445                 1450                 1455             


Glu Asn  Arg Ser Pro Ala Phe  Leu Pro Asn Thr Phe  Pro Arg Ser 
    1460                 1465                 1470             


Gly Val  Thr Asn Phe Asn Thr  Ser Val Ser Gln Glu  Gly Ser Glu 
    1475                 1480                 1485             


Ile Ile  Lys Gln Ala Leu Glu  Thr Ala Gly Ile Pro  Ser Thr Phe 
    1490                 1495                 1500             


Glu Gly  Ala Glu Met Leu Ser  His Val Ser Thr Gly  Cys Val Ser 
    1505                 1510                 1515             


Asp Ala  Ser Gln Val Asn Ala  Thr Val Met Pro Asn  Pro Thr Val 
    1520                 1525                 1530             


Pro Pro  Leu Leu His Thr Val  Cys His Pro Asn Thr  Leu Leu Thr 
    1535                 1540                 1545             


Asn Gln  Asn Arg Thr Ser Asn  Ser Lys Thr Ser Ser  Ile Glu Glu 
    1550                 1555                 1560             


Cys Ser  Ser Leu Pro Val Phe  Pro Thr Asn Asp Leu  Leu Leu Lys 
    1565                 1570                 1575             


Thr Val  Glu Asn Gly Leu Cys  Ser Ser Ser Phe Pro  Asn Ser Gly 
    1580                 1585                 1590             


Gly Pro  Ser Gln Asn Phe Thr  Ser Asn Ser Ser Arg  Val Ser Val 
    1595                 1600                 1605             


Ile Ser  Gly Pro Gln Asn Thr  Arg Ser Ser His Leu  Asn Lys Lys 
    1610                 1615                 1620             


Gly Asn  Ser Ala Ser Lys Arg  Arg Lys Lys Val Ala  Pro Pro Leu 
    1625                 1630                 1635             


Ile Ala  Pro Asn Ala Ser Gln  Asn Leu Val Thr Ser  Asp Leu Thr 
    1640                 1645                 1650             


Thr Met  Gly Leu Ile Ala Lys  Ser Val Glu Ile Pro  Thr Thr Asn 
    1655                 1660                 1665             


Leu His  Ser Asn Val Ile Pro  Thr Cys Glu Pro Gln  Ser Leu Val 
    1670                 1675                 1680             


Glu Asn  Leu Thr Gln Lys Leu  Asn Asn Val Asn Asn  Gln Leu Phe 
    1685                 1690                 1695             


Met Thr  Asp Val Lys Glu Asn  Phe Lys Thr Ser Leu  Glu Ser His 
    1700                 1705                 1710             


Thr Val  Leu Ala Pro Leu Thr  Leu Lys Thr Glu Asn  Gly Asp Ser 
    1715                 1720                 1725             


Gln Met  Met Ala Leu Asn Ser  Cys Thr Thr Ser Ile  Asn Ser Asp 
    1730                 1735                 1740             


Leu Gln  Ile Ser Glu Asp Asn  Val Ile Gln Asn Phe  Glu Lys Thr 
    1745                 1750                 1755             


Leu Glu  Ile Ile Lys Thr Ala  Met Asn Ser Gln Ile  Leu Glu Val 
    1760                 1765                 1770             


Lys Ser  Gly Ser Gln Gly Ala  Gly Glu Thr Ser Gln  Asn Ala Gln 
    1775                 1780                 1785             


Ile Asn  Tyr Asn Ile Gln Leu  Pro Ser Val Asn Thr  Val Gln Asn 
    1790                 1795                 1800             


Asn Lys  Leu Pro Asp Ser Ser  Pro Phe Ser Ser Phe  Ile Ser Val 
    1805                 1810                 1815             


Met Pro  Thr Lys Ser Asn Ile  Pro Gln Ser Glu Val  Ser His Lys 
    1820                 1825                 1830             


Glu Asp  Gln Ile Gln Glu Ile  Leu Glu Gly Leu Gln  Lys Leu Lys 
    1835                 1840                 1845             


Leu Glu  Asn Asp Leu Ser Thr  Pro Ala Ser Gln Cys  Val Leu Ile 
    1850                 1855                 1860             


Asn Thr  Ser Val Thr Leu Thr  Pro Thr Pro Val Lys  Ser Thr Ala 
    1865                 1870                 1875             


Asp Ile  Thr Val Ile Gln Pro  Val Ser Glu Met Ile  Asn Ile Gln 
    1880                 1885                 1890             


Phe Asn  Asp Lys Val Asn Lys  Pro Phe Val Cys Gln  Asn Gln Gly 
    1895                 1900                 1905             


Cys Asn  Tyr Ser Ala Met Thr  Lys Asp Ala Leu Phe  Lys His Tyr 
    1910                 1915                 1920             


Gly Lys  Ile His Gln Tyr Thr  Pro Glu Met Ile Leu  Glu Ile Lys 
    1925                 1930                 1935             


Lys Asn  Gln Leu Lys Phe Ala  Pro Phe Lys Cys Val  Val Pro Thr 
    1940                 1945                 1950             


Cys Thr  Lys Thr Phe Thr Arg  Asn Ser Asn Leu Arg  Ala His Cys 
    1955                 1960                 1965             


Gln Leu  Val His His Phe Thr  Thr Glu Glu Met Val  Lys Leu Lys 
    1970                 1975                 1980             


Ile Lys  Arg Pro Tyr Gly Arg  Lys Ser Gln Ser Glu  Asn Val Pro 
    1985                 1990                 1995             


Ala Ser  Arg Ser Thr Gln Val  Lys Lys Gln Leu Ala  Met Thr Glu 
    2000                 2005                 2010             


Glu Asn  Lys Lys Glu Ser Gln  Pro Ala Leu Glu Leu  Arg Ala Glu 
    2015                 2020                 2025             


Thr Gln  Asn Thr His Ser Asn  Val Ala Val Ile Pro  Glu Lys Gln 
    2030                 2035                 2040             


Leu Val  Glu Lys Lys Ser Pro  Asp Lys Thr Glu Ser  Ser Leu Gln 
    2045                 2050                 2055             


Val Ile  Thr Val Thr Ser Glu  Gln Cys Asn Thr Asn  Ala Leu Thr 
    2060                 2065                 2070             


Asn Thr  Gln Thr Lys Gly Arg  Lys Ile Arg Arg His  Lys Lys Glu 
    2075                 2080                 2085             


Lys Glu  Glu Lys Lys Arg Lys  Lys Pro Val Ser Gln  Ser Leu Glu 
    2090                 2095                 2100             


Phe Pro  Thr Arg Tyr Ser Pro  Tyr Arg Pro Tyr Arg  Cys Val His 
    2105                 2110                 2115             


Gln Gly  Cys Phe Ala Ala Phe  Thr Ile Gln Gln Asn  Leu Ile Leu 
    2120                 2125                 2130             


His Tyr  Gln Ala Val His Lys  Ser Asp Leu Pro Ala  Phe Ser Ala 
    2135                 2140                 2145             


Glu Val  Glu Glu Glu Ser Glu  Ala Gly Lys Glu Ser  Glu Glu Thr 
    2150                 2155                 2160             


Glu Thr  Lys Gln Thr Leu Lys  Glu Phe Arg Cys Gln  Val Ser Asp 
    2165                 2170                 2175             


Cys Ser  Arg Ile Phe Gln Ala  Ile Thr Gly Leu Ile  Gln His Tyr 
    2180                 2185                 2190             


Met Lys  Leu His Glu Met Thr  Pro Glu Glu Ile Glu  Ser Met Thr 
    2195                 2200                 2205             


Ala Ser  Val Asp Val Gly Lys  Phe Pro Cys Asp Gln  Leu Glu Cys 
    2210                 2215                 2220             


Lys Ser  Ser Phe Thr Thr Tyr  Leu Asn Tyr Val Val  His Leu Glu 
    2225                 2230                 2235             


Ala Asp  His Gly Ile Gly Leu  Arg Ala Ser Lys Thr  Glu Glu Asp 
    2240                 2245                 2250             


Gly Val  Tyr Lys Cys Asp Cys  Glu Gly Cys Asp Arg  Ile Tyr Ala 
    2255                 2260                 2265             


Thr Arg  Ser Asn Leu Leu Arg  His Ile Phe Asn Lys  His Asn Asp 
    2270                 2275                 2280             


Lys His  Lys Ala His Leu Ile  Arg Pro Arg Arg Leu  Thr Pro Gly 
    2285                 2290                 2295             


Gln Glu  Asn Met Ser Ser Lys  Ala Asn Gln Glu Lys  Ser Lys Ser 
    2300                 2305                 2310             


Lys His  Arg Gly Thr Lys His  Ser Arg Cys Gly Lys  Glu Gly Ile 
    2315                 2320                 2325             


Lys Met  Pro Lys Thr Lys Arg  Lys Lys Lys Asn Asn  Leu Glu Asn 
    2330                 2335                 2340             


Lys Asn  Ala Lys Ile Val Gln  Ile Glu Glu Asn Lys  Pro Tyr Ser 
    2345                 2350                 2355             


Leu Lys  Arg Gly Lys His Val  Tyr Ser Ile Lys Ala  Arg Asn Asp 
    2360                 2365                 2370             


Ala Leu  Ser Glu Cys Thr Ser  Arg Phe Val Thr Gln  Tyr Pro Cys 
    2375                 2380                 2385             


Met Ile  Lys Gly Cys Thr Ser  Val Val Thr Ser Glu  Ser Asn Ile 
    2390                 2395                 2400             


Ile Arg  His Tyr Lys Cys His  Lys Leu Ser Lys Ala  Phe Thr Ser 
    2405                 2410                 2415             


Gln His  Arg Asn Leu Leu Ile  Val Phe Lys Arg Cys  Cys Asn Ser 
    2420                 2425                 2430             


Gln Val  Lys Glu Thr Ser Glu  Gln Glu Gly Ala Lys  Asn Asp Val 
    2435                 2440                 2445             


Lys Asp  Ser Asp Thr Cys Val  Ser Glu Ser Asn Asp  Asn Ser Arg 
    2450                 2455                 2460             


Thr Thr  Ala Thr Val Ser Gln  Lys Glu Val Glu Lys  Asn Glu Lys 
    2465                 2470                 2475             


Asp Glu  Met Asp Glu Leu Thr  Glu Leu Phe Ile Thr  Lys Leu Ile 
    2480                 2485                 2490             


Asn Glu  Asp Ser Thr Ser Val  Glu Thr Gln Ala Asn  Thr Ser Ser 
    2495                 2500                 2505             


Asn Val  Ser Asn Asp Phe Gln  Glu Asp Asn Leu Cys  Gln Ser Glu 
    2510                 2515                 2520             


Arg Gln  Lys Ala Ser Asn Leu  Lys Arg Val Asn Lys  Glu Lys Asn 
    2525                 2530                 2535             


Val Ser  Gln Asn Lys Lys Arg  Lys Val Glu Lys Ala  Glu Pro Ala 
    2540                 2545                 2550             


Ser Ala  Ala Glu Leu Ser Ser  Val Arg Lys Glu Glu  Glu Thr Ala 
    2555                 2560                 2565             


Val Ala  Ile Gln Thr Ile Glu  Glu His Pro Ala Ser  Phe Asp Trp 
    2570                 2575                 2580             


Ser Ser  Phe Lys Pro Met Gly  Phe Glu Val Ser Phe  Leu Lys Phe 
    2585                 2590                 2595             


Leu Glu  Glu Ser Ala Val Lys  Gln Lys Lys Asn Thr  Asp Lys Asp 
    2600                 2605                 2610             


His Pro  Asn Thr Gly Asn Lys  Lys Gly Ser His Ser  Asn Ser Arg 
    2615                 2620                 2625             


Lys Asn  Ile Asp Lys Thr Ala  Val Thr Ser Gly Asn  His Val Cys 
    2630                 2635                 2640             


Pro Cys  Lys Glu Ser Glu Thr  Phe Val Gln Phe Ala  Asn Pro Ser 
    2645                 2650                 2655             


Gln Leu  Gln Cys Ser Asp Asn  Val Lys Ile Val Leu  Asp Lys Asn 
    2660                 2665                 2670             


Leu Lys  Asp Cys Thr Glu Leu  Val Leu Lys Gln Leu  Gln Glu Met 
    2675                 2680                 2685             


Lys Pro  Thr Val Ser Leu Lys  Lys Leu Glu Val His  Ser Asn Asp 
    2690                 2695                 2700             


Pro Asp  Met Ser Val Met Lys  Asp Ile Ser Ile Gly  Lys Ala Thr 
    2705                 2710                 2715             


Gly Arg  Gly Gln Tyr 
    2720             


<210>  1012
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  1012

Met Asp Leu Pro Ala Leu Leu Pro Ala Pro Thr Ala Arg Gly Gly Gln 
1               5                   10                  15      


His Gly Gly Gly Pro Gly Pro Leu Arg Arg Ala Pro Ala Pro Leu Gly 
            20                  25                  30          


Ala Ser Pro Ala Arg Arg Arg Leu Leu Leu Val Arg Gly Pro Glu Asp 
        35                  40                  45              


Gly Gly Pro Gly Ala Arg Pro Gly Glu Ala Ser Gly Pro Ser Pro Pro 
    50                  55                  60                  


Pro Ala Glu Asp Asp Ser Asp Gly Asp Ser Phe Leu Val Leu Leu Glu 
65                  70                  75                  80  


Val Pro His Gly Gly Ala Ala Ala Glu Ala Ala Gly Ser Gln Glu Ala 
                85                  90                  95      


Glu Pro Gly Ser Arg Val Asn Leu Ala Ser Arg Pro Glu Gln Gly Pro 
            100                 105                 110         


Ser Gly Pro Ala Ala Pro Pro Gly Pro Gly Val Ala Pro Ala Gly Ala 
        115                 120                 125             


Val Thr Ile Ser Ser Gln Asp Leu Leu Val Arg Leu Asp Arg Gly Val 
    130                 135                 140                 


Leu Ala Leu Ser Ala Pro Pro Gly Pro Ala Thr Ala Gly Ala Ala Ala 
145                 150                 155                 160 


Pro Arg Arg Ala Pro Gln Ala Ser Gly Pro Ser Thr Pro Gly Tyr Arg 
                165                 170                 175     


Cys Pro Glu Pro Gln Cys Ala Leu Ala Phe Ala Lys Lys His Gln Leu 
            180                 185                 190         


Lys Val His Leu Leu Thr His Gly Gly Gly Gln Gly Arg Arg Pro Phe 
        195                 200                 205             


Lys Cys Pro Leu Glu Gly Cys Gly Trp Ala Phe Thr Thr Ser Tyr Lys 
    210                 215                 220                 


Leu Lys Arg His Leu Gln Ser His Asp Lys Leu Arg Pro Phe Gly Cys 
225                 230                 235                 240 


Pro Val Gly Gly Cys Gly Lys Lys Phe Thr Thr Val Tyr Asn Leu Lys 
                245                 250                 255     


Ala His Met Lys Gly His Glu Gln Glu Ser Leu Phe Lys Cys Glu Val 
            260                 265                 270         


Cys Ala Glu Arg Phe Pro Thr His Ala Lys Leu Ser Ser His Gln Arg 
        275                 280                 285             


Ser His Phe Glu Pro Glu Arg Pro Tyr Lys Cys Asp Phe Pro Gly Cys 
    290                 295                 300                 


Glu Lys Thr Phe Ile Thr Val Ser Ala Leu Phe Ser His Asn Arg Ala 
305                 310                 315                 320 


His Phe Arg Glu Gln Glu Leu Phe Ser Cys Ser Phe Pro Gly Cys Ser 
                325                 330                 335     


Lys Gln Tyr Asp Lys Ala Cys Arg Leu Lys Ile His Leu Arg Ser His 
            340                 345                 350         


Thr Gly Glu Arg Pro Phe Ile Cys Asp Ser Asp Ser Cys Gly Trp Thr 
        355                 360                 365             


Phe Thr Ser Met Ser Lys Leu Leu Arg His Arg Arg Lys His Asp Asp 
    370                 375                 380                 


Asp Arg Arg Phe Thr Cys Pro Val Glu Gly Cys Gly Lys Ser Phe Thr 
385                 390                 395                 400 


Arg Ala Glu His Leu Lys Gly His Ser Ile Thr His Leu Gly Thr Lys 
                405                 410                 415     


Pro Phe Glu Cys Pro Val Glu Gly Cys Cys Ala Arg Phe Ser Ala Arg 
            420                 425                 430         


Ser Ser Leu Tyr Ile His Ser Lys Lys His Val Gln Asp Val Gly Ala 
        435                 440                 445             


Pro Lys Ser Arg Cys Pro Val Ser Thr Cys Asn Arg Leu Phe Thr Ser 
    450                 455                 460                 


Lys His Ser Met Lys Ala His Met Val Arg Gln His Ser Arg Arg Gln 
465                 470                 475                 480 


Asp Leu Leu Pro Gln Leu Glu Ala Pro Ser Ser Leu Thr Pro Ser Ser 
                485                 490                 495     


Glu Leu Ser Ser Pro Gly Gln Ser Glu Leu Thr Asn Met Asp Leu Ala 
            500                 505                 510         


Ala Leu Phe Ser Asp Thr Pro Ala Asn Ala Ser Gly Ser Ala Gly Gly 
        515                 520                 525             


Ser Asp Glu Ala Leu Asn Ser Gly Ile Leu Thr Ile Asp Val Thr Ser 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Gly Asn Leu Pro Ala Asn Asn Ser Ser Leu 
545                 550                 555                 560 


Gly Pro Met Glu Pro Leu Val Leu Val Ala His Ser Asp Ile Pro Pro 
                565                 570                 575     


Ser Leu Asp Ser Pro Leu Val Leu Gly Thr Ala Ala Thr Val Leu Gln 
            580                 585                 590         


Gln Gly Ser Phe Ser Val Asp Asp Val Gln Thr Val Ser Ala Gly Ala 
        595                 600                 605             


Leu Gly Cys Leu Val Ala Leu Pro Met Lys Asn Leu Ser Asp Asp Pro 
    610                 615                 620                 


Leu Ala Leu Thr Ser Asn Ser Asn Leu Ala Ala His Ile Thr Thr Pro 
625                 630                 635                 640 


Thr Ser Ser Ser Thr Pro Arg Glu Asn Ala Ser Val Pro Glu Leu Leu 
                645                 650                 655     


Ala Pro Ile Lys Val Glu Pro Asp Ser Pro Ser Arg Pro Gly Ala Val 
            660                 665                 670         


Gly Gln Gln Glu Gly Ser His Gly Leu Pro Gln Ser Thr Leu Pro Ser 
        675                 680                 685             


Pro Ala Glu Gln His Gly Ala Gln Asp Thr Glu Leu Ser Ala Gly Thr 
    690                 695                 700                 


Gly Asn Phe Tyr Leu Glu Ser Gly Gly Ser Ala Arg Thr Asp Tyr Arg 
705                 710                 715                 720 


Ala Ile Gln Leu Ala Lys Glu Lys Lys Gln Arg Gly Ala Gly Ser Asn 
                725                 730                 735     


Ala Gly Ala Ser Gln Ser Thr Gln Arg Lys Ile Lys Glu Gly Lys Met 
            740                 745                 750         


Ser Pro Pro His Phe His Ala Ser Gln Asn Ser Trp Leu Cys Gly Ser 
        755                 760                 765             


Leu Val Val Pro Ser Gly Gly Arg Pro Gly Pro Ala Pro Ala Ala Gly 
    770                 775                 780                 


Val Gln Cys Gly Ala Gln Gly Val Gln Val Gln Leu Val Gln Asp Asp 
785                 790                 795                 800 


Pro Ser Gly Glu Gly Val Leu Pro Ser Ala Arg Gly Pro Ala Thr Phe 
                805                 810                 815     


Leu Pro Phe Leu Thr Val Asp Leu Pro Val Tyr Val Leu Gln Glu Val 
            820                 825                 830         


Leu Pro Ser Ser Gly Gly Pro Ala Gly Pro Glu Ala Thr Gln Phe Pro 
        835                 840                 845             


Gly Ser Thr Ile Asn Leu Gln Asp Leu Gln 
    850                 855             


<210>  1013
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  1013

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


<210>  1014
<211>  2013
<212>  DNA
<213>  Homo sapiens

<400>  1014
atggcaaaga gaataaaagc taagcccact tcagacaaac ctggaagtcc atatcgctct       60

gtcacacact tcgactcact agctgtaata gacatccctg gagcagatac tctggataaa      120

ttatttgacc atgctgtatc caagtttggg aagaaggaca gccttgggac cagggaaatc      180

ctaagtgaag aaaatgaaat gcagccaaat ggaaaagttt ttaagaagtt aattcttggg      240

aattataaat ggatgaacta tcttgaagtg aatcgcagag tgaataactt tggtagtgga      300

ctcactgcac tgggactaaa accaaagaac accattgcca tcttctgtga gaccagggcc      360

gaatggatga ttgcagcaca gacctgcttt aagtacaact ttcctcttgt gactttatat      420

gccacacttg gcaaagaagc agtagttcat gggctaaatg aatctgaggc ttcctatctg      480

attaccagtg ttgaacttct ggaaagtaaa cttaagactg cattgttaga tatcagttgt      540

gttaaacata tcatttatgt ggacaataag gctatcaata aagcagagta ccctgaagga      600

tttgagattc acagcatgca atcagtagaa gagttgggat ctaacccaga aaacttgggc      660

attcctccaa gtagaccaac gccttcagac atggccattg ttatgtatac tagtggttct      720

actggccgac ctaagggagt gatgatgcat catagcaatt tgatagctgg aatgacaggc      780

cagtgtgaaa gaatacctgg actgggaccg aaggacacat atattggcta cttgcctttg      840

gctcatgtgc tagaactgac agcagagata tcttgcttta cctatggctg caggattgga      900

tattcttctc cgcttacact ctctgaccag tccagcaaaa ttaaaaaagg aagcaaagga      960

gactgtactg tactgaagcc cacacttatg gctgctgttc cggaaatcat ggatagaatt     1020

tataagaatg ttatgagcaa agtccaagag atgaattata ttcagaaaac tctgttcaag     1080

atagggtatg attacaaatt ggaacagatc aaaaagggat atgatgcacc tctttgcaat     1140

ctgttactgt ttaaaaaggt caaggccctg ctgggaggga atgtccgcat gatgctgtct     1200

ggaggggccc cgctatctcc tcagacacac cgattcatga atgtctgctt ctgctgccca     1260

attggccagg gttatggact gacagaatca tgtggtgctg ggacagttac tgaagtaact     1320

gactatacta ctggcagagt tggagcacct cttatttgct gtgaaattaa gctaaaagac     1380

tggcaagaag gcggttatac aattaatgac aagccaaacc ccagaggtga aatcgtaatt     1440

ggtggacaga acatctccat gggatatttt aaaaatgaag agaaaacagc agaagattat     1500

tctgtggatg aaaatggaca aaggtggttt tgcactggtg atattggaga attccatccc     1560

gatggatgtt tacagattat agatcgtaag aaagatctag tgaagttaca agcaggagag     1620

tatgtatctc ttgggaaagt agaagctgca ctgaagaatt gtccacttat tgacaacatc     1680

tgtgcttttg ccaaaagtga tcagtcctat gtgatcagtt ttgtggttcc taaccagaaa     1740

aggttgacac ttttggcaca acagaaaggg gtagaaggaa cttgggttga tatctgcaat     1800

aatcctgcta tggaagctga aatactgaaa gaaattcgag aagctgcaaa tgccatgaaa     1860

ttggagcgat ttgaaattcc aatcaaggtt cgattaagcc cagagccatg gacccctgaa     1920

actggtttgg taactgatgc tttcaaactg aaaaggaagg agctgaggaa ccattacctc     1980

aaagacattg aacgaatgta tgggggcaaa taa                                  2013


<210>  1015
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  1015
atgacgtcag tcagagaaaa tattctcttt ggaatgggaa atcctctgct tgacatctct       60

gctgtagtgg acaaagattt ccttgataag tattctctga aaccaaatga ccaaatcttg      120

gctgaagaca aacacaagga actgtttgat gaacttgtga aaaaattcaa agtcgaatat      180

catgctggtg gctctaccca gaattcaatt aaagtggctc agtggatgat tcaacagcca      240

cacaaagcag caacattttt tggatgcatt gggatagata aatttgggga gatcctgaag      300

agaaaagctg ctgaagccca tgtggatgct cattactacg agcagaatga gcagccaaca      360

ggaacttgtg ctgcatgcat cactggtgac aacaggtccc tcatagctaa tcttgctgct      420

gccaattgtt ataaaaagga aaaacatctt gatctggaga aaaactggat gttggtagaa      480

aaagcaagag tttgttatat agcaggcttt tttcttacag tttccccaga gtcagtatta      540

aaggtggctc accatgcttc tgaaaacaac aggattttca ctttgaatct atctgcaccg      600

tttattagcc agttctacaa ggaatcattg atgaaagtta tgccttatgt tgatatactt      660

tttggaaatg agacagaagc tgccactttt gctagagagc aaggctttga gactaaagac      720

attaaagaga tagccaaaaa gacacaagcc ctgccaaaga tgaactcaaa gaggcagcga      780

atcgtgatct tcacccaagg gagagatgac actataatgg ctacagaaag tgaagtcact      840

gcttttgctg tcttggatca agaccagaaa gaaattattg ataccaatgg agctggagat      900

gcatttgttg gaggttttct gtctcaactg gtctctgaca agcctctgac tgaatgtatc      960

cgtgctggcc actatgcagc aagcatcata attagacgga ctggctgcac ctttcctgag     1020

aagccagact tccactga                                                   1038


<210>  1016
<211>  1455
<212>  DNA
<213>  Homo sapiens

<400>  1016
atggcggctg gaggcgatca tggttcgccc gacagctacc gctcacctct tgcctcccgc       60

tatgccagcc cggagatgtg cttcgtgttt agcgacaggt ataaattccg gacatggcgg      120

cagctgtggc tgtggctggc ggaggccgag cagacattgg gtttgcctat cacagatgaa      180

caaatccagg agatgaaatc aaacctggag aacatcgact tcaagatggc agctgaggaa      240

gagaaacgtt tacgacatga tgtgatggct cacgtgcaca catttggcca ctgctgtcca      300

aaagctgcag gcattattca ccttggtgct acttcttgct atgttggaga caatactgac      360

ttgattattc ttagaaatgc acttgacctg cttttgccaa agcttgccag agtgatctct      420

cggcttgccg actttgctaa ggaacgagcc agtctaccca cattaggttt cacacatttc      480

cagcctgcac agctgaccac agttgggaaa cgttgctgtc tttggattca ggatctttgc      540

atggatctcc agaacttgaa gcgtgtccga gatgacctgc gcttccgggg agtaaagggt      600

accactggca ctcaggccag tttcctgcag ctctttgagg gagatgacca taaggtagag      660

cagcttgaca agatggtgac agaaaaggca ggatttaaga gagctttcat catcacaggg      720

cagacatata cacgaaaagt ggatattgaa gtactgtctg tgctggctag cttgggggca      780

tcagtgcaca agatttgcac cgacatacgc ctcctggcaa acctcaagga gatggaggaa      840

ccctttgaaa aacagcagat tggctcaagt gcgatgccat ataagcggaa tcccatgcgt      900

tcagaacgtt gctgcagtct tgcccgccac ctgatgaccc ttgtcatgga cccgctacag      960

acagcatctg tccagtggtt tgaacgcaca ctggatgata gtgccaaccg acggatctgt     1020

ttggccgagg catttcttac cgcagatact atattgaata cgctgcagaa catttctgaa     1080

ggattggtcg tgtaccccaa agtaattgaa cggcgcattc ggcaagagct gcctttcatg     1140

gccacagaga acatcatcat ggccatggtc aaagctggag gtagccgcca ggattgccat     1200

gagaaaatca gagtgctttc tcagcaggca gcttctgtgg ttaagcagga agggggtgac     1260

aatgacctca tagagcgtat ccaggttgat gcctacttca gtcccattca ctcccagttg     1320

gatcatttac tggatccttc ttctttcact ggtcgtgcct cccagcaggt gcagagattc     1380

ttagaagagg aggtgtatcc cctgttaaaa ccatatgaaa gcgtgatgaa ggtgaaagca     1440

gaattatgtc tgtag                                                      1455


<210>  1017
<211>  6828
<212>  DNA
<213>  Homo sapiens

<400>  1017
atggcggcgg agcggcgctg tggaagtatg cgagacttaa gagctcaagt gactagtggt       60

ctcctgccat ttccagaagt gactcttcaa gcccttggag aagacgaaat aacattagaa      120

tctgtgcttc gtggaaagtt tgctgcaggg aaaaatggac ttgcttgctt ggcttgtggt      180

ccacaacttg aggtagtaaa ctctataaca ggagagcgat tgtctgctta cagattcagt      240

ggagtcaatg aacagcctcc tgtagtttta gctgtgaaag aattctcttg gcagaagaga      300

actggattat taataggatt ggaagaaaca gaagggagtg ttctctgtct ttatgacctt      360

ggaatatcaa aagtagttaa agcagttgtt cttcctggaa gggtaacagc tattgaacct      420

ataattaatc atggaggagc cagtgcaagc actcagcatt tacatccaag tctgcgatgg      480

ctttttggag tggcagctgt ggtcactgat gttggacaga tccttcttgt tgacctatgt      540

ttggatgact tgtcatgcaa tcaaaatgaa gttgaagcat cagatcttga agttctaact      600

ggtatcccag ctgaagtacc acacattaga gaaagtgtaa tgagacaagg gcgccatctg      660

tgtttccagt tagtaagtcc aacaggaaca gctgtttcaa ctcttagtta cataagcagg      720

acaaatcagc ttgctgtagg tttttctgat ggctatctag cactttggaa catgaaaagc      780

atgaaaagag aatattacat acaattggaa agtggacaag ttcctgtata tgctgtcact      840

tttcaagaac ctgagaatga tcctcggaat tgctgttact tgtgggctgt tcagtctaca      900

caagatagtg aaggggatgt tttgagtttg catctgctgc agctggcctt tggtaataga      960

aagtgtttgg catcaggaca aatcttatat gaggggttag aatactgtga agaaagatac     1020

accctggacc tgacaggtgg catgttccct ttgaggggac agacgagtaa taccaaattg     1080

ttgggatgcc agagtataga gaaatttcga tctcatggtg acagggagga aggcgtgaat     1140

gaagctctat cgcctgacac tagtgtttca gtctttacct ggcaggtgaa tatatatgga     1200

cagggaaagc cttctgtata tttggggctt tttgatataa atcgttggta tcatgcacaa     1260

atgccagatt cgttaaggtc aggagaatat ctacataatt gctcttattt tgcactgtgg     1320

tcattggagt ctgttgtaag taggacttct ccacatggca tcttggatat attagtacat     1380

gagagaagtt taaatagagg agtccctcct tcatatccac ctcccgagca gttttttaat     1440

ccaagcactt ataattttga tgccacttgt ttgttaaact cgggagttgt tcatttaact     1500

tgtactggct ttcagaagga gactttgact tttttaaaga aatcaggtcc atcactcaat     1560

gaactcattc ctgatggtta taatcgatgt cttgtagctg gccttctttc cccaagattt     1620

gttgatgttc agccttccag tttaagccaa gaagaacagt tagaagctat attgtcagca     1680

gcaattcaga ctagttccct gggacttttg actggttata tccgaagatg gataacagaa     1740

gaacaaccaa attctgccac taatttgcgc tttgttcttg aatggacgtg gaataaagtg     1800

gttctcacaa aagaggaatt tgacagacta tgtgtgccat tatttgatgg ttcgtgtcat     1860

ttcatggatc cacaaactat acagtctatc cagcaatgct atttgcttct tagcaatctt     1920

aatatagtct tgagctgttt tgcatcagaa gcccgagaga tcactgagag aggactgata     1980

gacttaagca ataagtttgt ggtttcccac ctcatctgtc agtatgcaca agtggttctt     2040

tggttctctc attctgggct tttaccagaa ggcatagatg attctgtgca gttgtcaagg     2100

ttatgctaca actaccctgt aattcagaac tactacacca gtcgtcgaca gaagtttgag     2160

cgtttatcaa gagggaagtg gaatcccgat tgcttgatga ttgatggact ggtttctcag     2220

ttaggagagc gaattgagaa gttgtggaaa cgagatgaag gaggcacagg aaaatatcct     2280

cctgctagtc tgcatgcagt acttgatatg tacctattag acggcgttac tgaagcagcc     2340

aaacactcta ttaccattta tttgctactt gatattatgt attcctttcc caacaaaaca     2400

gacactccca ttgaatcttt cccaactgta tttgccattt cttggggcca agttaaactt     2460

attcaggggt tttggttgat agatcataat gactatgaga gtggtttgga tcttttgttt     2520

catccagcta ctgcaaaacc tttgtcatgg caacattcaa agattattca ggcattcatg     2580

agtcagggcg agcacagaca agccctcaga tatattcaga caatgaagcc aacagtgtcc     2640

agtggtaacg atgttatcct tcacctcact gttttgcttt ttaataggtg tatggttgaa     2700

gcctggaatt ttttgcggca acattgcaat aggttgaata tagaggagtt actgaagcac     2760

atgtatgaag tctgtcagga aatgggcttg atggaagatt tactgaagtt accatttaca     2820

gacactgagc aggaatgttt agtgaaattt ttgcagtcca gtgccagcgt tcagaatcat     2880

gaattccttt tagtgcacca tttgcagcgt gccaattatg tgcctgcctt gaagctgaac     2940

caaactctga agattaatgt tatgaatgat cgtgatcctc gtttgcggga gagatcactg     3000

gctcgaaatt ctatattaga ccagtatgga aaaatccttc ctagagtcca tcgaaaatta     3060

gccattgaac gagctaagcc ttatcatctg tcaacatcat cagtttttcg attagtttct     3120

agacccaaac cattatcagc agttccaaag caagttgtaa caggaactgt gttgacaaga     3180

tctgttttca tcaacaatgt gttatctaaa attggagaag tttgggcaag caaagaacct     3240

ataaatagca ccacaccttt caatagttct aaaatagaag aaccatctcc tatagtgtat     3300

tcgctcccag ctccagagct gcctgaggca ttttttggaa caccaatttc aaaagcatca     3360

caaaaaattt ctagactgct agatttggtt gttcagcctg tcccccggcc ttctcagtgt     3420

tcggagttta ttcagcaaag ctccatgaaa tctcctttgt acctagtatc ccgttcactg     3480

ccctcaagtt cgcaattaaa aggatcgcct caggccatct ccagggcttc agaattacat     3540

ttgcttgaaa ctcctcttgt agttaagaaa gctaaaagtt tggccatgtc agttactact     3600

tctggatttt ctgagttcac tcctcagtcc atcctgaggt ctactcttcg atcaacacct     3660

ttagcatctc cctctccatc acctggaagg tctcctcaac gacttaaaga aactagaatt     3720

tcatttgtgg aagaagatgt ccacccaaaa tggattcctg gggctgcaga tgatagcaaa     3780

ttagaagtat ttactacacc taaaaaatgt gcagttccag tggaaactga atggctgaag     3840

agcaaagata ggaccacatc ttttttcctg aacagccctg aaaaggagca tcaagaaatg     3900

gatgaggggt cacaaagttt agagaaactg gatgtgagca aaggaaacag cagtgtttca     3960

atcacatccg atgagactac cttagagtat caggatgcac cgtcaccgga agaccttgaa     4020

gagactgttt tcacggcctc taagcccaaa agctcttcca ctgcactaac tactaatgta     4080

actgaacaaa ctgaaaagga tggagataaa gatgtatttg catcagaagt aactccttca     4140

gacctacaga aacaaatggg caatttagaa gatgcagaaa caaaggatct cttagttgca     4200

gcagaggcat tttcagaatt gaatcactta agcccggttc aaggaactga agcttctctt     4260

tgtgcaccat cagtctatga agggaaaatc ttcacccaga agtccaaggt accagtgttg     4320

gacgaaggat taacatctgt tgaaacctac acccctgcaa ttagagcaaa tgacaataaa     4380

tctatggctg atgtccttgg tgatggtgga aactcctcgc tcactatctc tgaaggtcct     4440

attgtctctg agcgcaggct taaccaggaa gtagcgctga acttaaaaga agatcatgaa     4500

gtagaagttg gtgtactaaa agaaagtgtt gacttaccag aagaaaagct tccaatttct     4560

gacagccctc ctgatactca agaaattcat gtgattgaac aagaaaagct tgaagctcaa     4620

gattcaggag aagaggctag gaatctttca tttaatgagt tatatccctc tggaacactt     4680

aagcttcagt acaattttga tactattgac caacagtttt gtgacttagc tgataacaaa     4740

gacactgctg aatgtgacat tgctgaagta gatggggaac tttttgtggc tcaaagcaac     4800

tttaccttga tattggaagg tgaagaagga gaagttgagc caggtgattt tgcatcatct     4860

gatgtgttac ctaaagcagc taacacagca actgaagaaa aacttgtatg cagtggggaa     4920

aatgataatc atggacaaat tgcaaatttg ccatctgccg taactagtga ccaaaagtcc     4980

caaaaagtag acactttacc atatgtgcct gaacctatta aagtagcaat tgcagaaaat     5040

ttactagatg taattaaaga cacaagaagt aaagaaatta cttcagatac aatggaacag     5100

tccattcatg aaacaatacc tttagtgagc caaaacataa tgtgtcccac taaattggtc     5160

aaatctgcat ttaagactgc tcaggaaaca agcacaatga ctatgaatgt cagccaggtt     5220

gatgacgtgg tttcctccaa aactcgtacg agaggtcaac gtatccaaaa cgtgaatgtc     5280

aaatcagcac aacaggaagc atcagcagat gttgctactc ctaagatgcc agggcagtca     5340

gtcaggaaga aaactaggaa ggcaaaagaa atttctgaag cttctgaaaa catctattct     5400

gatgtcagag gactatctca gaaccagcaa atacctcaaa attctgttac gcctaggaga     5460

ggaaggagaa agaaagaagt taatcaggac atactagaaa acaccagttc tgtggaacaa     5520

gaattacaga tcactacagg tagggaatca aaaagattaa aatcatctca gctgttggaa     5580

ccagcagttg aagaaactac taaaaaagaa gttaaggttt catctgttac aaaaaggact     5640

cctagaagaa ttaaaagatc tgtagaaaat caggaaagtg ttgaaattat aaatgatcta     5700

aaagttagta cggtaacaag tcctagcaga atgatcagaa aattgagaag tactaattta     5760

gatgcttctg aaaatacagg aaataagcaa gatgataaat ccagtgacaa gcagctgcgt     5820

attaaacatg ttagaagggt cagagggaga gaagttagtc catcagatgt gagagaagac     5880

tccaaccttg agtcatctca gttgactgtt caagcagaat ttgatatgtc tgccatacct     5940

agaaaacgtg gtagaccaag aaaaatcaat ccatctgaag atgtaggatc taaggctgtt     6000

aaggaagaga gaagccccaa gaagaaagaa gctcccagca ttagaaggag atctacaaga     6060

aataccccag ctaaaagtga aaatgttgat gttggaaaac cagctttagg aaaatccatt     6120

ttagtgccaa acgaggaact ttcgatggtg atgagctcta agaaaaaact tacaaaaaag     6180

actgaaagtc aaagccaaaa acgttcattg cactcagtat cagaagaacg cacagatgaa     6240

atgacacata aagaaacaaa tgagcaggaa gaaagattgc tcgccacagc ttccttcact     6300

aaatcatccc gcagcagcag gactcggtct agcaaggcca tcttgttgcc ggacctttct     6360

gaaccaaaca atgagccttt attttctcca gcgtcagaag ttccaaggaa agcaaaagct     6420

aaaaaaatag aggttcctgc acagctgaaa gaattagttt cggatttatc ttctcagttt     6480

gtcatctcac ctcctgcttt aaggagcaga caaaaaaaca catccaataa gaacaagctt     6540

gaagatgaac tgaaagatga tgcacaatca gtagaaactc tgggaaagcc aaaagcgaaa     6600

cgaatcagga cgtcaaaaac aaaacaagca agcaaaaaca cagaaaaaga aagtgcttgg     6660

tcacctcctc ccatagaaat tcggctgatt tcccccttgg ctagcccagc tgacggagtc     6720

aagagcaaac caagaaaaac tacagaagtg acaggaacag gtcttggaag gaacagaaag     6780

aaactgtctt cctatccaaa gcaaatttta cgcagaaaaa tgctgtaa                  6828


<210>  1018
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  1018
atgccgaagc gtgggaaaaa gggagcggtg gcggaagacg gggatgagct caggacagag       60

ccagaggcca agaagagtaa gacggccgca aagaaaaatg acaaagaggc agcaggagag      120

ggcccagccc tgtatgagga ccccccagat cagaaaacct cacccagtgg caaacctgcc      180

acactcaaga tctgctcttg gaatgtggat gggcttcgag cctggattaa gaagaaagga      240

ttagattggg taaaggaaga agccccagat atactgtgcc ttcaagagac caaatgttca      300

gagaacaaac taccagctga acttcaggag ctgcctggac tctctcatca atactggtca      360

gctccttcgg acaaggaagg gtacagtggc gtgggcctgc tttcccgcca gtgcccactc      420

aaagtttctt acggcatagg cgatgaggag catgatcagg aaggccgggt gattgtggct      480

gaatttgact cgtttgtgct ggtaacagca tatgtaccta atgcaggccg aggtctggta      540

cgactggagt accggcagcg ctgggatgaa gcctttcgca agttcctgaa gggcctggct      600

tcccgaaagc cccttgtgct gtgtggagac ctcaatgtgg cacatgaaga aattgacctt      660

cgcaacccca aggggaacaa aaagaatgct ggcttcacgc cacaagagcg ccaaggcttc      720

ggggaattac tgcaggctgt gccactggct gacagcttta ggcacctcta ccccaacaca      780

ccctatgcct acaccttttg gacttatatg atgaatgctc gatccaagaa tgttggttgg      840

cgccttgatt actttttgtt gtcccactct ctgttacctg cattgtgtga cagcaagatc      900

cgttccaagg ccctcggcag tgatcactgt cctatcaccc tatacctagc actgtga         957


<210>  1019
<211>  2412
<212>  DNA
<213>  Homo sapiens

<400>  1019
atgaagaagc agttcaaccg catgaagcag ctggctaacc agaccgtggg cagagctgag       60

aaaacagaag tccttagtga agatctatta cagattgaga gacgcctgga cacggtgcgg      120

tcaatatgcc accattccca taagcgcttg gtggcatgtt tccagggcca gcatggcacc      180

gatgccgaga ggagacacaa aaaactgcct ctgacagctc ttgctcaaaa tatgcaagaa      240

gcatcgactc agctggaaga ctctctcctg gggaagatgc tggagacgtg tggagatgct      300

gagaatcagc tggctctcga gctctcccag cacgaagtct ttgttgagaa ggagatcgtg      360

gaccctctgt acggcatagc tgaggtggag attcccaaca tccagaagca gaggaagcag      420

cttgcaagat tggtgttaga ctgggattca gtcagagcca ggtggaacca agctcacaaa      480

tcctcaggaa ccaactttca ggggcttcca tcaaaaatag atactctaaa ggaagagatg      540

gatgaagctg gaaataaagt agaacagtgc aaggatcaac ttgcagcaga catgtacaac      600

tttatggcca aagaagggga gtatggcaaa ttctttgtta cgttattaga agcccaagca      660

gattaccata gaaaagcatt agcagtctta gaaaagaccc tccccgaaat gcgagcccat      720

caagataagt gggcggaaaa accagccttt gggactcccc tagaagaaca cctgaagagg      780

agcgggcgcg agattgcgct gcccattgaa gcctgtgtca tgctgcttct ggagacaggc      840

atgaaggagg agggcctttt ccgaattggg gctggggcct ccaagttaaa gaagctgaaa      900

gctgctttgg actgttctac ttctcacctg gatgagttct attcagaccc ccatgctgta      960

gcaggtgctt taaaatccta tttacgggaa ttgcctgaac ctttgatgac ttttaatctg     1020

tatgaagaat ggacacaagt tgcaagtgtg caggatcaag acaaaaaact tcaagacttg     1080

tggagaacat gtcagaagtt gccaccacaa aattttgtta actttagata tttgatcaag     1140

ttccttgcaa agcttgctca gaccagcgat gtgaataaaa tgactcccag caacattgcg     1200

attgtgttag gccctaactt gttatgggcc agaaatgaag gaacacttgc tgaaatggca     1260

gcagccacat ccgtccatgt ggttgcagtg attgaaccca tcattcagca tgccgactgg     1320

ttcttccctg aagaggtgga atttaatgta tcagaagcat ttgtacctct caccaccccg     1380

agttctaatc actcattcca cactggaaac gactctgact cggggaccct ggagaggaag     1440

cggcctgcta gcatggcggt gatggaagga gacttggtga agaaggaaag tcctcccaaa     1500

ccgaaggacc ctgtatctgc agctgtgcca gcaccaggga gaaacaacag tcagatagca     1560

tctggccaaa atcagcccca ggcagctgct ggctcccacc agctctccat gggccaacct     1620

cacaatgctg cagggcccag cccgcataca ctgcgccgag ctgttaaaaa acccgctcca     1680

gcacccccga aaccgggcaa cccacctcct ggccaccccg ggggccagag ttcttcagga     1740

acatctcagc atccacccag tctgtcacca aagccaccca cccgaagccc ctctcctccc     1800

acccagcaca cgggccagcc tccaggccag ccctccgccc cctcccagct ctcagcaccc     1860

cggaggtact ccagcagctt gtctccaatc caagctccca atcacccacc gccgcagccc     1920

cctacgcagg ccacgccact gatgcacacc aaacccaata gccagggccc tcccaacccc     1980

atggcattgc ccagtgagca tggacttgag cagccatctc acacccctcc ccagactcca     2040

acgcccccca gtactccgcc cctaggaaaa cagaacccca gtctgccagc tcctcagacc     2100

ctggcagggg gtaaccctga aactgcacag ccacatgctg gaaccttacc gagaccgaga     2160

ccagtaccaa agccaaggaa ccggcccagc gtgcccccac ccccccaacc tcctggtgtc     2220

cactcagctg gggacagcag cctcaccaac acagcaccaa cagcttccaa gatagtaaca     2280

gactccaatt ccagggtttc agaaccgcat cgcagcatct ttcctgaaat gcactcagac     2340

tcagccagca aagacgtgcc tggccgcatc ctgctggata tagacaatga taccgagagc     2400

actgccctgt ga                                                         2412


<210>  1020
<211>  6858
<212>  DNA
<213>  Homo sapiens

<400>  1020
atggccgcgc aggtcgcccc cgccgccgcc agcagcctgg gcaacccgcc gccgccgccg       60

ccctcggagc tgaagaaagc cgagcagcag cagcgggagg aggcgggggg cgaggcggcg      120

gcggcggcag cggccgagcg cggggaaatg aaggcagccg ccgggcagga aagcgagggc      180

cccgccgtgg ggccgccgca gccgctggga aaggagctgc aggacggggc cgagagcaat      240

gggggtggcg gcggcggcgg agccggcagc ggcggcgggc ccggcgcgga gccggacctg      300

aagaactcga acgggaacgc gggccctagg cccgccctga acaataacct cacggagccg      360

cccggcggcg gcggtggcgg cagcagcgat ggggtggggg cgcctcctca ctcagccgcg      420

gccgccttgc cgcccccagc ctacggcttc gggcaaccct acggccggag cccgtctgcc      480

gtcgccgccg ccgcggccgc cgtcttccac caacaacatg gcggacaaca aagccctggc      540

ctggcagcgc tgcagagcgg cggcggcggg ggcctggagc cctacgcggg gccccagcag      600

aactctcacg accacggctt ccccaaccac cagtacaact cctactaccc caaccgcagc      660

gcctaccccc cgcccgcccc ggcctacgcg ctgagctccc cgagaggtgg cactccgggc      720

tccggcgcgg cggcggctgc cggctccaag ccgcctccct cctccagcgc ctccgcctcc      780

tcgtcgtctt cgtccttcgc tcagcagcgc ttcggggcca tggggggagg cggcccctcc      840

gcggccggcg ggggaactcc ccagcccacc gccaccccca ccctcaacca actgctcacg      900

tcgcccagct cggcccgggg ctaccagggc taccccgggg gcgactacag tggcgggccc      960

caggacgggg gcgccggcaa gggcccggcg gacatggcct cgcagtgttg gggggctgcg     1020

gcggcggcag ctgcggcggc ggccgcctcg ggaggggccc aacaaaggag ccaccacgcg     1080

cccatgagcc ccgggagcag cggcggcggg gggcagccgc tcgcccggac ccctcagcca     1140

tccagtccaa tggatcagat gggcaagatg agacctcagc catatggcgg gactaaccca     1200

tactcgcagc aacagggacc tccgtcagga ccgcagcaag gacatgggta cccagggcag     1260

ccatacgggt cccagacccc gcagcggtac ccgatgacca tgcagggccg ggcgcagagt     1320

gccatgggcg gcctctctta tacacagcag attcctcctt atggacaaca aggccccagc     1380

gggtatggtc aacagggcca gactccatat tacaaccagc aaagtcctca ccctcagcag     1440

cagcagccac cctactccca gcaaccaccg tcccagaccc ctcatgccca accttcgtat     1500

cagcagcagc cacagtctca accaccacag ctccagtcct ctcagcctcc atactcccag     1560

cagccatccc agcctccaca tcagcagtcc ccggctccat acccctccca gcagtcgacg     1620

acacagcagc acccccagag ccagcccccc tactcacagc cacaggctca gtctccttac     1680

cagcagcagc aacctcagca gccagcaccc tcgacgctct cccagcaggc tgcgtatcct     1740

cagccccagt ctcagcagtc ccagcaaact gcctattccc agcagcgctt ccctccaccg     1800

caggagctat ctcaagattc atttgggtct caggcatcct cagccccctc aatgacctcc     1860

agtaagggag ggcaagaaga tatgaacctg agccttcagt caagaccctc cagcttgcct     1920

gatctatctg gttcaataga tgacctcccc atggggacag aaggagctct gagtcctgga     1980

gtgagcacat cagggatttc cagcagccaa ggagagcaga gtaatccagc tcagtctcct     2040

ttctctcctc atacctcccc tcacctgcct ggcatccgag gcccttcccc gtcccctgtt     2100

ggctctcccg ccagtgttgc tcagtctcgc tcaggaccac tctcgcctgc tgcagtgcca     2160

ggcaaccaga tgccacctcg gccacccagt ggccagtcgg acagcatcat gcatccttcc     2220

atgaaccaat caagcattgc ccaagatcga ggttatatgc agaggaaccc ccagatgccc     2280

cagtacagtt ccccccagcc cggctcagcc ttatctccgc gtcagccttc cggaggacag     2340

atacacacag gcatgggctc ctaccagcag aactccatgg ggagctatgg tccccagggg     2400

ggtcagtatg gcccacaagg tggctacccc aggcagccaa actataatgc cttgcccaat     2460

gccaactacc ccagtgcagg catggctgga ggcataaacc ccatgggtgc cggaggtcaa     2520

atgcatggac agcctggcat cccaccttat ggcacactcc ctccagggag gatgagtcac     2580

gcctccatgg gcaaccggcc ttatggccct aacatggcca atatgccacc tcaggttggg     2640

tcagggatgt gtcccccacc agggggcatg aaccggaaaa cccaagaaac tgctgtcgcc     2700

atgcatgttg ctgccaactc tatccaaaac aggccgccag gctaccccaa tatgaatcaa     2760

gggggcatga tgggaactgg acctccttat ggacaaggga ttaatagtat ggctggcatg     2820

atcaaccctc agggaccccc atattccatg ggtggaacca tggccaacaa ttctgcaggg     2880

atggcagcca gcccagagat gatgggcctt ggggatgtaa agttaactcc agccaccaaa     2940

atgaacaaca aggcagatgg gacacccaag acagaatcca aatccaagaa atccagttct     3000

tctactacaa ccaatgagaa gatcaccaag ttgtatgagc tgggtggtga gcctgagagg     3060

aagatgtggg tggaccgtta tctggccttc actgaggaga aggccatggg catgacaaat     3120

ctgcctgctg tgggtaggaa acctctggac ctctatcgcc tctatgtgtc tgtgaaggag     3180

attggtggat tgactcaggt caacaagaac aaaaaatggc gggaacttgc aaccaacctc     3240

aatgtgggca catcaagcag tgctgccagc tccttgaaaa agcagtatat ccagtgtctc     3300

tatgcctttg aatgcaagat tgaacgggga gaagaccctc ccccagacat ctttgcagct     3360

gctgattcca agaagtccca gcccaagatc cagcctccct ctcctgcggg atcaggatct     3420

atgcaggggc cccagactcc ccagtcaacc agcagttcca tggcagaagg aggagactta     3480

aagccaccaa ctccagcatc cacaccacac agtcagatcc ccccattgcc aggcatgagc     3540

aggagcaatt cagttgggat ccaggatgcc tttaatgatg gaagtgactc cacattccag     3600

aagcggaatt ccatgactcc aaaccctggg tatcagccca gtatgaatac ctctgacatg     3660

atggggcgca tgtcctatga gccaaataag gatccttatg gcagcatgag gaaagctcca     3720

gggagtgatc ccttcatgtc ctcagggcag ggccccaacg gcgggatggg tgacccctac     3780

agtcgtgctg ccggccctgg gctaggaaat gtggcgatgg gaccacgaca gcactatccc     3840

tatggaggtc cttatgacag agtgaggacg gagcctggaa tagggcctga gggaaacatg     3900

agcactgggg ccccacagcc gaatctcatg ccttccaacc cagactcggg gatgtattct     3960

cctagccgct accccccgca gcagcagcag cagcagcagc aacgacatga ttcctatggc     4020

aatcagttct ccacccaagg caccccttct ggcagcccct tccccagcca gcagactaca     4080

atgtatcaac agcaacagca gaattacaag cggccaatgg atggcacata tggccctcct     4140

gccaagcggc acgaagggga gatgtacagc gtgccataca gcactgggca ggggcagcct     4200

cagcagcagc agttgccccc agcccagccc cagcctgcca gccagcaaca agctgcccag     4260

ccttcccctc agcaagatgt atacaaccag tatggcaatg cctatcctgc cactgccaca     4320

gctgctactg agcgccgacc agcaggcggc ccccagaacc aatttccatt ccagtttggc     4380

cgagaccgtg tctctgcacc ccctggcacc aatgcccagc aaaacatgcc accacaaatg     4440

atgggcggcc ccatacaggc atcagctgag gttgctcagc aaggcaccat gtggcagggg     4500

cgtaatgaca tgacctataa ttatgccaac aggcagagca cgggctctgc cccccagggc     4560

cccgcctatc atggcgtgaa ccgaacagat gaaatgctgc acacagatca gagggccaac     4620

cacgaaggct cgtggccttc ccatggcaca cgccagcccc catatggtcc ctctgcccct     4680

gtgcccccca tgacaaggcc ccctccatct aactaccagc ccccaccaag catgcagaat     4740

cacattcctc aggtatccag ccctgctccc ctgccccggc caatggagaa ccgcacctct     4800

cctagcaagt ctccattcct gcactctggg atgaaaatgc agaaggcagg tcccccagta     4860

cctgcctcgc acatagcacc tgcccctgtg cagcccccca tgattcggcg ggatatcacc     4920

ttcccacctg gctctgttga agccacacag cctgtgttga agcagaggag gcggctcaca     4980

atgaaagaca ttggaacccc ggaggcatgg cgggtaatga tgtccctcaa gtctggtctc     5040

ctggcagaga gcacatgggc attagatacc atcaacatcc tgctgtatga tgacaacagc     5100

atcatgacct tcaacctcag tcagctccca gggttgctag agctccttgt agaatatttc     5160

cgacgatgcc tgattgagat ctttggcatt ttaaaggagt atgaggtggg tgacccagga     5220

cagagaacgc tactggatcc tgggaggttc agcaaggtgt ctagtccagc tcccatggag     5280

ggtggggaag aagaagaaga acttctaggt cctaaactag aagaggaaga agaagaggaa     5340

gtagttgaaa atgatgagga gatagccttt tcaggcaagg acaagccagc ttcagagaat     5400

agtgaggaga agctgatcag taagtttgac aagcttccag taaagatcgt acagaagaat     5460

gatccatttg tggtggactg ctcagataag cttgggcgtg tgcaggagtt tgacagtggc     5520

ctgctgcact ggcggattgg tgggggggac accactgagc atatccagac ccacttcgag     5580

agcaagacag agctgctgcc ttcccggcct cacgcaccct gcccaccagc ccctcggaag     5640

catgtgacaa cagcagaggg tacaccaggg acaacagacc aggaggggcc cccacctgat     5700

ggacctccag aaaaacggat cacagccact atggatgaca tgttgtctac tcggtctagc     5760

accttgaccg aggatggagc taagagttca gaggccatca aggagagcag caagtttcca     5820

tttggcatta gcccagcaca gagccaccgg aacatcaaga tcctagagga cgaaccccac     5880

agtaaggatg agaccccact gtgtaccctt ctggactggc aggattctct tgccaagcgc     5940

tgcgtctgtg tgtccaatac cattcgaagc ctgtcatttg tgccaggcaa tgactttgag     6000

atgtccaaac acccagggct gctgctcatc ctgggcaagc tgatcctgct gcaccacaag     6060

cacccagaac ggaagcaggc accactaact tatgaaaagg aggaggaaca ggaccaaggg     6120

gtgagctgca acaaagtgga gtggtggtgg gactgcttgg agatgctccg ggaaaacacc     6180

ttggttacac tcgccaacat ctcggggcag ttggacctat ctccataccc cgagagcatt     6240

tgcctgcctg tcctggacgg actcctacac tgggcagttt gcccttcagc tgaagcccag     6300

gacccctttt ccaccctggg ccccaatgcc gtcctttccc cgcagagact ggtcttggaa     6360

accctcagca aactcagcat ccaggacaac aatgtggacc tgattctggc cacacccccc     6420

ttcagccgcc tggagaagtt gtatagcact atggtgcgct tcctcagtga ccgaaagaac     6480

ccggtgtgcc gggagatggc tgtggtactg ctggccaacc tggctcaggg ggacagcctg     6540

gcagctcgtg ccattgcagt gcagaagggc agtatcggca acctcctggg cttcctagag     6600

gacagccttg ccgccacaca gttccagcag agccaggcca gcctcctcca catgcagaac     6660

ccaccctttg agccaactag tgtggacatg atgcggcggg ctgcccgcgc gctgcttgcc     6720

ttggccaagg tggacgagaa ccactcagag tttactctgt acgaatcacg gctgttggac     6780

atctcggtat caccgttgat gaactcattg gtttcacaag tcatttgtga tgtactgttt     6840

ttgattggcc agtcatga                                                   6858


<210>  1021
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  1021
atgtcagtgg acatgaatag ccaggggtct gacagcaatg aagaggacta tgacccaaat       60

tgtgaggaag aggaagaaga agaagaagac gaccctgggg acatagagga ctattacgtg      120

ggagtagcca gcgatgtgga gcagcagggg gctgatgcct ttgatcccga ggagtaccag      180

ttcacttgct tgacctacaa ggaatctgag ggtgccctca atgagcacat gaccagctta      240

gcttctgtcc taaaggtatc tcattcagtt gctaaactta tattagttaa tttccactgg      300

caagtttcag agatattgga cagatacaag tccaattctg ctcaactgct tgttgaggct      360

cgagttcagc ctaatccatc aaaacatgtt cccacatccc atccccctca ccactgtgca      420

gtgtgtatgc agtttgtgcg aaaggaaaac ctactctctc tggcctgtca gcaccagttt      480

tgccgcagct gctgggagca gcactgctca gttctcgtca aggacggcgt gggcgtggga      540

gtctcttgca tggctcagga ctgtccactc cgtacaccag aggactttgt gtttccattg      600

cttcccaatg aagaattgag agagaaatac aggcgctacc tcttcaggga ctatgtggag      660

agtcattacc agctccagct gtgccctggt gcagactgcc ccatggttat tcgggtacag      720

gagcctagag ctcgccgagt acagtgcaat cggtgcaacg aggtcttctg tttcaagtgt      780

cgtcagatgt atcacgcacc cacagactgt gccacaatcc ggaaatggct cacgaagtgt      840

gcagacgact ctgaaacagc caactacatt agtgctcaca ctaaagactg tcccaagtgc      900

aacatctgca ttgagaagaa tggaggctgc aatcacatgc aatgctccaa atgtaaacac      960

gacttctgct ggatgtgtct aggagattgg aagactcatg gcagtgaata ctatgagtgc     1020

agtcgttaca aggagaatcc tgacatcgtg aaccagagcc aacaagccca ggcgagggaa     1080

gccctcaaga agtacttatt ctactttgag aggtgggaaa accacaataa aagcttgcag     1140

ctagaggcac agacatacca gcggattcac gagaagattc aggagagggt catgaacaat     1200

ctggggacat ggatcgactg gcagtaccta cagaatgctg ccaagctctt ggccaagtgt     1260

cgatacaccc tgcaatacac ctacccatat gcatattaca tggagtccgg acccaggaag     1320

aagctgtttg aataccagca ggctcagctg gaggctgaga tcgaaaacct ctcatggaaa     1380

gtggagcgtg cagacagcta tgacagaggg gacttggaga accagatgca tatagcggag     1440

cagcggagga gaaccctgct gaaagatttc catgacacct aa                        1482


<210>  1022
<211>  4308
<212>  DNA
<213>  Homo sapiens

<400>  1022
atgagggaaa agggacgtag gaagaagggc aggacctggg cggaggccgc caagacggtc       60

ttagaaaaat accccaatac acccatgagt cataaagaaa ttcttcaagt tatccagaga      120

gaaggactaa aagaaatcag aagtgggact tctcctcttg catgcctgaa tgcaatgctt      180

cacacaaact ccagaggtga agagggcatc ttctataagg ttccaggtag aatgggagta      240

tatactttga agaaagatgt gccggatggg gtgaaagagc tgtcagaagg ttcagaagaa      300

agcagtgatg gtcagtcaga ttcccagagt tctgagaaca gcagcagcag cagtgatggt      360

ggcagcaaca aggagggaaa aaagagcagg tggaaaagga aagtatcgtc gtcctccccg      420

cagtcaggct gcccatcacc caccattcca gcaggtaaag tcatttctcc atcacagaag      480

cacagcaaga aggcactaaa gcaggcgcta aagcagcaac agcagaagaa gcagcagcag      540

caatgcaggc caagcatatc catctcctcc aaccagcatc tctcactaaa gactgtcaaa      600

gcagccagtg actctgtacc tgccaaacct gcaacatggg aaggaaagca atctgatgga      660

cagacaggca gccctcaaaa ctcaaactcc agcttttctt cctcagttaa agtggaaaat      720

actttactag gcttggggaa gaagtcattc cagagatctg agagactcca taccagacaa      780

atgaaaagaa ctaaatgtgc tgacattgac gttgagacac cggactccat tctggttaat      840

acaaatctgc gagcactgat caacaagcac acattttcag tccttcctgg agattgccag      900

caacgactgc ttttactact cccagaggta gatcgacagg ttggtccaga tggtttaatg      960

aagttaaatg gctcagccct taacaatgaa ttcttcactt cagcagccca aggctggaag     1020

gaaagactct cagaaggtga gtttacacct gagatgcagg tgagaattcg acaagagatt     1080

gagaaggaga aaaaagtgga gccatggaaa gaacaattct ttgaaagcta ctatgggcag     1140

agttctggcc tgagccttga agattctaag aaattgacag cttctcccag tgatcccaaa     1200

gtaaagaaaa ccccagctga acaaccaaaa tccatgcctg tgtcagaggc ctctcttatc     1260

agaatagttc cagtagtctc ccagtcagag tgtaaagaag aagcattgca aatgtcatca     1320

ccaggcagaa aagaagagtg tgaaagccaa ggtgaagtgc agccgaactt ctccacatct     1380

tcagagcccc tgctttcctc agctctcaat acacatgagc ttagcagcat tcttcccatc     1440

aagtgcccaa aggatgagga tctcttggag cagaagccag tcacctctgc tgaacaggaa     1500

tctgagaaga accatctcac cacagcttct aattataaca aaagtgaaag ccaagaatct     1560

ttagttacat cgccaagcaa acccaagagt cctggggttg aaaaaccaat agtgaagccc     1620

acagcaggag cgggtccaca ggagactaat atgaaagaac ctctagcaac tcttgttgat     1680

cagagcccag aaagcctcaa gaggaagtct tccctcaccc aagaagaggc ccctgtgagc     1740

tgggagaaga ggccacgtgt cactgagaat cgccagcacc agcagccatt tcaggtctca     1800

ccacagccct ttctcaatag aggggacaga atccaggtgc gaaaagtacc acctctcaag     1860

atcccggtct ccagaatctc ccccatgccg tttcatccat cgcaggtctc tcccagggct     1920

cgttttccag tctccatcac tagtcctaac agaacaggag ccagaactct tgcagacatc     1980

aaagcaaaag cccaactggt caaagcacag agggcagcag ctgccgctgc cgccgcagct     2040

gctgcagccg cctcagttgg agggaccatt ccaggacctg gcccaggggg tggacaaggt     2100

ccaggagagg gtggtgaagg gcagactgct agaggaggca gtccaggctc agacagagtc     2160

agtgaaactg gaaagggccc cacactggaa ctggcaggaa ctggaagcag gggaggtacg     2220

agagagcttt taccctgtgg tccagagact cagccccagt ctgagaccaa gaccacccca     2280

agccaggcac agcctcatag tgtctctgga gcacaactac agcaaacccc cccagtgcct     2340

ccaacacctg ccgtcagtgg agcatgcaca agtgtcccat caccagccca catagagaaa     2400

ttggataatg aaaaactgaa ccccaccaga gcaacagcca cagtggcctc tgtcagccat     2460

ccacaagggc ccagtagttg cagacaggag aaagcacctt ctccaacagg tcctgctcta     2520

atctcaggtg cctcacctgt tcattgtgca gctgatggca cagttgagct caaagcaggt     2580

cctagtaaga atatacctaa cccttcagcc tcatcaaaga cagatgctag tgtgccagtg     2640

gctgtaactc cctccccttt aacatcttta ttgaccacag ccactttaga aaagcttcct     2700

gtaccccagg tcagtgcaac tacagcacct gctggatcag ctccaccctc gagcactttg     2760

ccagcagctt ctagccttaa aaccccagga acttctttaa acatgaatgg acccacttta     2820

agaccaacct ctagtatccc tgctaataat cctttagtga ctcagctgct tcaaggcaaa     2880

gatgttccca tggagcaaat tctgcctaaa cctctcacca aagttgaaat gaaaacggtt     2940

ccactgactg caaaagagga aagggggatg ggagcgctca tagctaccaa cacaacagaa     3000

aatagcacca gagaggaagt taatgagaga cagtcccatc cagctacgca gcagcagctg     3060

ggcaaaacct tgcaaagtaa gcagctcccc caggttccaa ggccccttca gctcttttca     3120

gctaaggagc tgagggactc cagcattgac acacaccaat accacgaagg actaagtaaa     3180

gcaacccaag atcagatcct tcagactctc attcagaggg ttcggaggca gaatcttctc     3240

tcagttgtgc cgccctcaca gttcaacttc gctcactcag gtttccagct ggaagacatc     3300

tccacaagcc agaggttcat gctgggtttt gctggcagaa ggacatccaa acctgcaatg     3360

gcagggcact acttactgaa tatttctacc tacggccggg gctcagagag ctttaggagg     3420

acccattctg taaaccctga agatcgtttt tgtctaagca gccccactga agccttgaaa     3480

atgggatata cagactgtaa aaatgcaaca ggagagagta gcagcagcaa agaagatgac     3540

actgatgagg aaagtactgg tgatgagcag gaatctgtca cagtgaaaga ggagccccag     3600

gtttcccaga gtgctggcaa gggtgacaca agttcaggac ctcacagcag ggaaactcta     3660

tctaccagtg attgcttagc tagcaagaat gtgaaggctg agataccatt gaatgagcaa     3720

accactttaa gtaaggagaa ttacctgttc actagaggcc aaacatttga tgaaaagacc     3780

ctagccagag atttaattca ggcagcacag aagcagatgg ctcatgcagt gagaggtaag     3840

gcaatccgta gcagccccga gcttttcagt tctactgttc ttcctctgcc tgcagacagc     3900

cccacccacc agcccctact ccttccaccc ctgcaaaccc cgaagttgta tggaagcccc     3960

acccagatag ggccaagcta tagaggcatg atcaatgtct ccacctcatc tgacatggac     4020

cataactctg ctgtaccagg tagccaggta tctagcaatg taggtgatgt catgtcattt     4080

tcagtgactg tcactaccat ccctgctagc caagctatga atcccagcag ccatggccag     4140

accattcctg ttcaggcgtt ctccgaagag aacagcatag agggcacgcc ttcgaaatgt     4200

tactgccgct tgaaagccat gatcatgtgc aaaggctgtg gcgctttctg ccatgatgat     4260

tgcatcggcc cctccaaact gtgcgtctcc tgccttgtcg ttcggtaa                  4308


<210>  1023
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  1023
atgccgaagc acgagttctc tgtggacatg acctgtggag gctgtgctga agctgtctct       60

cgggtcctca ataagcttgg aggagttaag tatgacattg acctgcccaa caagaaggtc      120

tgcattgaat ctgagcacag catggacact ctgcttgcaa ccctgaagaa aacaggaaag      180

actgtttcct accttggcct tgagtag                                          207


<210>  1024
<211>  2994
<212>  DNA
<213>  Homo sapiens

<400>  1024
atggagaacg cgcacaccaa gacggtggag gaggtgctgg gccacttcgg cgtcaacgag       60

agtacggggc tgagcctgga acaggtcaag aagcttaagg agagatgggg ctccaacgag      120

ttaccggctg aagaaggaaa aaccttgctg gaacttgtga ttgagcagtt tgaagacttg      180

ctagttagga ttttattact ggcagcatgt atatcttttg ttttggcttg gtttgaagaa      240

ggtgaagaaa caattacagc ctttgtagaa ccttttgtaa ttttactcat attagtagcc      300

aatgcaattg tgggtgtatg gcaggaaaga aatgctgaaa atgccatcga agcccttaag      360

gaatatgagc ctgaaatggg caaagtgtat cgacaggaca gaaagagtgt gcagcggatt      420

aaagctaaag acatagttcc tggtgatatt gtagaaattg ctgttggtga caaagttcct      480

gctgatataa ggttaacttc catcaaatct accacactaa gagttgacca gtcaattctc      540

acaggtgaat ctgtctctgt catcaagcac actgatcccg tccctgaccc acgagctgtc      600

aaccaagata aaaagaacat gctgttttct ggtacaaaca ttgctgctgg gaaagctatg      660

ggagtggtgg tagcaactgg agttaacacc gaaattggca agatccggga tgaaatggtg      720

gcaacagaac aggagagaac accccttcag caaaaactag atgaatttgg ggaacagctt      780

tccaaagtca tctcccttat ttgcattgca gtctggatca taaatattgg gcacttcaat      840

gacccggttc atggagggtc ctggatcaga ggtgctattt actactttaa aattgcagtg      900

gccctggctg tagcagccat tcctgaaggt ctgcctgcag tcatcaccac ctgcctggct      960

cttggaactc gcagaatggc aaagaaaaat gccattgttc gaagcctccc gtctgtggaa     1020

acccttggtt gtacttctgt tatctgctca gacaagactg gtacacttac aacaaaccag     1080

atgtcagtct gcaggatgtt cattctggac agagtggaag gtgatacttg ttcccttaat     1140

gagtttacca taactggatc aacttatgca cctattggag aagtgcataa agatgataaa     1200

ccagtgaatt gtcaccagta tgatggtctg gtagaattag caacaatttg tgctctttgt     1260

aatgactctg ctttggatta caatgaggca aagggtgtgt atgaaaaagt tggagaagct     1320

acagagactg ctctcacttg cctagtagag aagatgaatg tatttgatac cgaattgaag     1380

ggtctttcta aaatagaacg tgcaaatgcc tgcaactcag tcattaaaca gctgatgaaa     1440

aaggaattca ctctagagtt ttcacgtgac agaaagtcaa tgtcggttta ctgtacacca     1500

aataaaccaa gcaggacatc aatgagcaag atgtttgtga agggtgctcc tgaaggtgtc     1560

attgacaggt gcacccacat tcgagttgga agtactaagg ttcctatgac ctctggagtc     1620

aaacagaaga tcatgtctgt cattcgagag tggggtagtg gcagcgacac actgcgatgc     1680

ctggccctgg ccactcatga caacccactg agaagagaag aaatgcacct tgaggactct     1740

gccaacttta ttaaatatga gaccaatctg accttcgttg gctgcgtggg catgctggat     1800

cctccgagaa tcgaggtggc ctcctccgtg aagctgtgcc ggcaagcagg catccgggtc     1860

atcatgatca ctggggacaa caagggcact gctgtggcca tctgtcgccg catcggcatc     1920

ttcgggcagg atgaggacgt gacgtcaaaa gctttcacag gccgggagtt tgatgaactc     1980

aacccctccg cccagcgaga cgcctgcctg aacgcccgct gttttgctcg agttgaaccc     2040

tcccacaagt ctaaaatcgt agaatttctt cagtcttttg atgagattac agctatgact     2100

ggcgatggcg tgaacgatgc tcctgctctg aagaaagccg agattggcat tgctatgggc     2160

tctggcactg cggtggctaa aaccgcctct gagatggtcc tggcggatga caacttctcc     2220

accattgtgg ctgccgttga ggaggggcgg gcaatctaca acaacatgaa acagttcatc     2280

cgctacctca tctcgtccaa cgtcggggaa gttgtctgta ttttcctgac agcagccctt     2340

ggatttcccg aggctttgat tcctgttcag ctgctctggg tcaatctggt gacagatggc     2400

ctgcctgcca ctgcactggg gttcaaccct cctgatctgg acatcatgaa taaacctccc     2460

cggaacccaa aggaaccatt gatcagcggg tggctctttt tccgttactt ggctattggc     2520

tgttacgtcg gcgctgctac cgtgggtgct gctgcatggt ggttcattgc tgctgacggt     2580

ggtccaagag tgtccttcta ccagctgagt catttcctac agtgtaaaga ggacaacccg     2640

gactttgaag gcgtggattg tgcaatcttt gaatccccat acccgatgac aatggcgctc     2700

tctgttctag taactataga aatgtgtaac gccctcaaca gcttgtccga aaaccagtcc     2760

ttgctgagga tgcccccctg ggagaacatc tggctcgtgg gctccatctg cctgtccatg     2820

tcactccact tcctgatcct ctatgtcgaa cccttgccac tcatcttcca gatcacaccg     2880

ctgaacgtga cccagtggct gatggtgctg aaaatctcct tgcccgtgat tctcatggat     2940

gagacgctca agtttgtggc ccgcaactac ctggaacctg caatactgga gtaa           2994


<210>  1025
<211>  1536
<212>  DNA
<213>  Homo sapiens

<400>  1025
atggcgctgc gggcgatgcg ggggattgtc aacggggccg cacccgagct acccgtgccc       60

accggtgggc cggcggtggg agctcgggag caggcgctgg cagtcagtcg gaactacctc      120

tcccagcctc gcctcacata caagacagta tctggagtca atggtccact agtgatctta      180

gatcatgtta agtttcccag gtatgctgaa attgtccatt tgaccttacc ggatggcaca      240

aagagaagtg ggcaagttct ggaagttagt ggttccaagg cagtagttca ggtatttgaa      300

gggacttcag gtatagatgc taagaaaacg tcctgtgagt ttactgggga tattctccga      360

acaccggtgt ctgaggatat gcttggtcgg gtattcaatg gatcgggaaa acccattgac      420

agaggtcctg ttgtactggc cgaagacttc cttgatatca tgggtcagcc aatcaaccct      480

caatgtcgaa tctacccaga ggaaatgatt cagactggca tttcggccat cgatgggatg      540

aacagtattg ctagggggca gaaaattcct atcttctctg ctgctgggct accacacaat      600

gagattgcag ctcagatctg tcgccaggct ggtttggtaa agaaatccaa agatgtagta      660

gactacagtg aggaaaattt tgcaattgta tttgctgcta tgggtgtaaa catggaaact      720

gcccggttct tcaaatctga ctttgaagaa aatggctcaa tggacaatgt ctgcctcttt      780

ttgaacttgg ctaatgaccc aaccattgag cgaattatca ctcctcgcct ggctctaacc      840

acagctgaat ttctggcgta ccaatgtgag aaacatgtat tggttattct aacagacatg      900

agttcttatg ctgaagcact tcgagaggtt tcagcagcca gggaagaggt acctggtcga      960

cgaggttttc caggttacat gtatacagat ttagccacga tatatgaacg cgctgggcga     1020

gtggaaggga gaaacggctc gattactcaa atccctattc taaccatgcc taatgatgat     1080

atcactcacc ccatcccaga cttgactggc tacattacag aggggcagat ctatgtggac     1140

agacagctgc acaacagaca gatttatcca cctatcaatg tgctgccctc actatcacgg     1200

ttaatgaagt ctgctattgg agaagggatg accaggaagg atcatgccga tgtatctaac     1260

cagctatatg cgtgctatgc tattggaaag gatgtgcaag ccatgaaagc tgtcgttgga     1320

gaagaagccc ttacctcaga tgatcttctc tacttggaat ttctgcagaa gtttgagagg     1380

aacttcattg ctcagggtcc ttacgaaaat cgcactgtct ttgagacttt ggacattggc     1440

tggcagctac tccgaatctt ccccaaagaa atgctgaaga gaatccctca gagcaccctc     1500

agcgaatttt accctcgaga ctctgcaaag cattag                               1536


<210>  1026
<211>  2322
<212>  DNA
<213>  Homo sapiens

<400>  1026
atgtctcgcc gcaagcaagg caaaccccag cacttaagca aacgggaatt ctcgcccgag       60

cctcttgaag ccattcttac agatgatgaa ccagaccacg gcccgttggg agctccagaa      120

ggggatcatg acctcctcac ctgtgggcag tgccagatga acttcccatt gggggacatt      180

cttattttta tcgagcacaa acggaaacaa tgcaatggca gcctctgctt agaaaaagct      240

gtggataagc caccttcccc ttcaccaatc gagatgaaaa aagcatccaa tcccgtggag      300

gttggcatcc aggtcacgcc agaggatgac gattgtttat caacgtcatc tagaggaatt      360

tgccccaaac aggaacacat agcagataaa cttctgcact ggaggggcct ctcctcccct      420

cgttctgcac atggagctct aatccccacg cctgggatga gtgcagaata tgccccgcag      480

ggtatttgta aagatgagcc cagcagctac acatgtacaa cttgcaaaca gccattcacc      540

agtgcatggt ttctcttgca acacgcacag aacactcatg gattaagaat ctacttagaa      600

agcgaacacg gaagtcccct gaccccgcgg gttggtatcc cttcaggact aggtgcagaa      660

tgtccttccc agccacctct ccatgggatt catattgcag acaataaccc ctttaacctg      720

ctaagaatac caggatcagt atcgagagag gcttccggcc tggcagaagg gcgctttcca      780

cccactcccc ccctgtttag tccaccaccg agacatcact tggaccccca ccgcatagag      840

cgcctggggg cggaagagat ggccctggcc acccatcacc cgagtgcctt tgacagggtg      900

ctgcggttga atccaatggc tatggagcct cccgccatgg atttctctag gagacttaga      960

gagctggcag ggaacacgtc tagcccaccg ctgtccccag gccggcccag ccctatgcaa     1020

aggttactgc aaccattcca gccaggtagc aagccgccct tcctggcgac gccccccctc     1080

cctcctctgc aatccgcccc tcctccctcc cagcccccgg tcaagtccaa gtcatgcgag     1140

ttctgcggca agacgttcaa atttcagagc aacctggtgg tgcaccggcg cagccacacg     1200

ggcgagaagc cctacaagtg caacctgtgc gaccacgcgt gcacccaggc cagcaagctg     1260

aagcgccaca tgaagacgca catgcacaaa tcgtccccca tgacggtcaa gtccgacgac     1320

ggtctctcca ccgccagctc cccggaaccc ggcaccagcg acttggtggg cagcgccagc     1380

agcgcgctca agtccgtggt ggccaagttc aagagcgaga acgaccccaa cctgatcccg     1440

gagaacgggg acgaggagga agaggaggac gacgaggaag aggaagaaga ggaggaagag     1500

gaggaggagg agctgacgga gagcgagagg gtggactacg gcttcgggct gagcctggag     1560

gcggcgcgcc accacgagaa cagctcgcgg ggcgcggtcg tgggcgtggg cgacgagagc     1620

cgcgccctgc ccgacgtcat gcagggcatg gtgctcagct ccatgcagca cttcagcgag     1680

gccttccacc aggtcctggg cgagaagcat aagcgcggcc acctggccga ggccgagggc     1740

cacagggaca cttgcgacga agactcggtg gccggcgagt cggaccgcat agacgatggc     1800

actgttaatg gccgcggctg ctccccgggc gagtcggcct cggggggcct gtccaaaaag     1860

ctgctgctgg gcagccccag ctcgctgagc cccttctcta agcgcatcaa gctcgagaag     1920

gagttcgacc tgcccccggc cgcgatgccc aacacggaga acgtgtactc gcagtggctc     1980

gccggctacg cggcctccag gcagctcaaa gatcccttcc ttagcttcgg agactccaga     2040

caatcgcctt ttgcctcctc gtcggagcac tcctcggaga acgggagttt gcgcttctcc     2100

acaccgcccg gggagctgga cggagggatc tcggggcgca gcggcacggg aagtggaggg     2160

agcacgcccc atattagtgg tccgggcccg ggcaggccca gctcaaaaga gggcagacgc     2220

agcgacactt gttcttcaca cacccccatt cggcgtagta cccagagagc tcaagatgtg     2280

tggcagtttt cggatggaag ctcgagagcc cttaagttct ga                        2322


<210>  1027
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  1027
atgccccgat gccccgcggg ggccatggac gaggggcccg tggacctgcg cacccggccc       60

aaggccgccg gactcccggg cgccgcgctg ccgctccgca agcgcccgct gcgcgcgccc      120

tccccggagc ccgccgctcc ccgcggcgct gcgggccttg tcgtccccct ggaccctctg      180

cgcggcggct gcgacctgcc ggcggtcccc gggccccccc acggcctggc ccggccggag      240

gcgctttact accccggagc cttactgcct ttgtacccca ctcgggccat gggctccccg      300

tttcctctgg tgaacctgcc tacaccccta taccccatga tgtgccccat ggaacacccc      360

ctttctgctg acatcgccat ggccacccgt gcagatgagg acggagacac gcctctccat      420

attgctgtgg tgcagggtaa cctgccagct gtgcaccggc tggtcaacct cttccagcag      480

gggggccggg agctcgacat ctacaacaac ctacggcaga caccgctcca cctggctgtg      540

atcaccacat taccgtctgt ggtccggctc ctggtgacag ctggtgccag ccccatggcg      600

ctggaccgcc atggccagac ggccgctcac ctggcgtgcg agcaccgcag cccgacctgc      660

ctgcgagccc tgctggacag cgcagctccg ggcacgttgg acctggaggc ccgcaattat      720

gacgggctca ccgccctgca cgtggcagtg aacaccgagt gccaagaaac cgtgcagctc      780

ttgctagagc gcggtgccga catcgacgca gtggacatta agagcggccg ctccccgctc      840

atccacgccg tggaaaacaa cagccttagc atggtgcagc tgctgctgca gcacggcgcc      900

aacgtgaacg cgcaaatgta ctccggcagc tccgccctgc actcagcgtc cggccgcggg      960

ctcctcccgc tggtgcgcac gctggtccgc agcggcgctg acagcagcct caagaactgc     1020

cacaacgaca cgccgctcat ggtggcgcgc agccgcaggg tcatcgacat cctgaggggg     1080

aaggccaccc ggcctgcttc cacctcccag ccagacccct cccctgaccg gagcgccaac     1140

acctcccccg agagcagcag ccgcctcagc tccaatggtc ttctctccgc atcaccatcc     1200

tcctcaccct cccagtctcc ccccagggac ccccctggat tccccatggc tcctcccaat     1260

ttcttccttc cttccccatc tccacccgcc ttcctgccct ttgctggggt cctccgaggc     1320

cctggccggc cggtgccccc ctccccagct ccaggaggca gctga                     1365


<210>  1028
<211>  2121
<212>  DNA
<213>  Homo sapiens

<400>  1028
atggcctcgc cggctgacag ctgtatccag ttcacccgcc atgccagtga tgttcttctc       60

aaccttaatc gtctccggag tcgagacatc ttgactgatg ttgtcattgt tgtgagccgt      120

gagcagttta gagcccataa aacggtcctc atggcctgca gtggcctgtt ctatagcatc      180

tttacagacc agttgaaatg caaccttagt gtgatcaatc tagatcctga gatcaaccct      240

gagggattct gcatcctcct ggacttcatg tacacatctc ggctcaattt gcgggagggc      300

aacatcatgg ctgtgatggc cacggctatg tacctgcaga tggagcatgt tgtggacact      360

tgccggaagt ttattaaggc cagtgaagca gagatggttt ctgccatcaa gcctcctcgt      420

gaagagttcc tcaacagccg gatgctgatg ccccaagaca tcatggccta tcggggtcgt      480

gaggtggtgg agaacaacct gccactgagg agcgcccctg ggtgtgagag cagagccttt      540

gcccccagcc tgtacagtgg cctgtccaca ccgccagcct cttattccat gtacagccac      600

ctccctgtca gcagcctcct cttctccgat gaggagtttc gggatgtccg gatgcctgtg      660

gccaacccct tccccaagga gcgggcactc ccatgtgata gtgccaggcc agtccctggt      720

gagtacagcc ggccgacttt ggaggtgtcc cccaatgtgt gccacagcaa tatctattca      780

cccaaggaaa caatcccaga agaggcacga agtgatatgc actacagtgt ggctgagggc      840

ctcaaacctg ctgccccctc agcccgaaat gccccctact tcccttgtga caaggccagc      900

aaagaagaag agagaccctc ctcggaagat gagattgccc tgcatttcga gccccccaat      960

gcacccctga accggaaggg tctggttagt ccacagagcc cccagaaatc tgactgccag     1020

cccaactcgc ccacagagtc ctgcagcagt aagaatgcct gcatcctcca ggcttctggc     1080

tcccctccag ccaagagccc cactgacccc aaagcctgca actggaagaa atacaagttc     1140

atcgtgctca acagcctcaa ccagaatgcc aaaccagagg ggcctgagca ggctgagctg     1200

ggccgccttt ccccacgagc ctacacggcc ccacctgcct gccagccacc catggagcct     1260

gagaaccttg acctccagtc cccaaccaag ctgagtgcca gcggggagga ctccaccatc     1320

ccacaagcca gccggctcaa taacatcgtt aacaggtcca tgacgggctc tccccgcagc     1380

agcagcgaga gccactcacc actctacatg caccccccga agtgcacgtc ctgcggctct     1440

cagtccccac agcatgcaga gatgtgcctc cacaccgctg gccccacgtt ccctgaggag     1500

atgggagaga cccagtctga gtactcagat tctagctgtg agaacggggc cttcttctgc     1560

aatgagtgtg actgccgctt ctctgaggag gcctcactca agaggcacac gctgcagacc     1620

cacagtgaca aaccctacaa gtgtgaccgc tgccaggcct ccttccgcta caagggcaac     1680

ctcgccagcc acaagaccgt ccataccggt gagaaaccct atcgttgcaa catctgtggg     1740

gcccagttca accggccagc caacctgaaa acccacactc gaattcactc tggagagaag     1800

ccctacaaat gcgaaacctg cggagccaga tttgtacagg tggcccacct ccgtgcccat     1860

gtgcttatcc acactggtga gaagccctat ccctgtgaaa tctgtggcac ccgtttccgg     1920

caccttcaga ctctgaagag ccacctgcga atccacacag gagagaaacc ttaccattgt     1980

gagaagtgta acctgcattt ccgtcacaaa agccagctgc gacttcactt gcgccagaag     2040

catggcgcca tcaccaacac caaggtgcaa taccgcgtgt cagccactga cctgcctccg     2100

gagctcccca aagcctgctg a                                               2121


<210>  1029
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  1029
atggcgtctt tctctgctga gaccaattca actgacctac tctcacagcc atggaatgag       60

cccccagtaa ttctctccat ggtcattctc agccttactt ttttactggg attgccaggc      120

aatgggctgg tgctgtgggt ggctggcctg aagatgcagc ggacagtgaa cacaatttgg      180

ttcctccacc tcaccttggc ggacctcctc tgctgcctct ccttgccctt ctcgctggct      240

cacttggctc tccagggaca gtggccctac ggcaggttcc tatgcaagct catcccctcc      300

atcattgtcc tcaacatgtt tgccagtgtc ttcctgctta ctgccattag cctggatcgc      360

tgtcttgtgg tattcaagcc aatctggtgt cagaatcatc gcaatgtagg gatggcctgc      420

tctatctgtg gatgtatctg ggtggtggct tttgtgatgt gcattcctgt gttcgtgtac      480

cgggaaatct tcactacaga caaccataat agatgtggct acaaatttgg tctctccagc      540

tcattagatt atccagactt ttatggagat ccactagaaa acaggtctct tgaaaacatt      600

gttcagccgc ctggagaaat gaatgatagg ttagatcctt cctctttcca aacaaatgat      660

catccttgga cagtccccac tgtcttccaa cctcaaacat ttcaaagacc ttctgcagat      720

tcactcccta ggggttctgc taggttaaca agtcaaaatc tgtattctaa tgtatttaaa      780

cctgctgatg tggtctcacc taaaatcccc agtgggtttc ctattgaaga tcacgaaacc      840

agcccactgg ataactctga tgcttttctc tctactcatt taaagctgtt ccctagcgct      900

tctagcaatt ccttctacga gtctgagcta ccacaaggtt tccaggatta ttacaattta      960

ggccaattca cagatgacga tcaagtgcca acacccctcg tggcaataac gatcactagg     1020

ctagtggtgg gtttcctgct gccctctgtt atcatgatag cctgttacag cttcattgtc     1080

ttccgaatgc aaaggggccg cttcgccaag tctcagagca aaacctttcg agtggccgtg     1140

gtggtggtgg ctgtctttct tgtctgctgg actccatacc acatttttgg agtcctgtca     1200

ttgcttactg acccagaaac tcccttgggg aaaactctga tgtcctggga tcatgtatgc     1260

attgctctag catctgccaa tagttgcttt aatcccttcc tttatgccct cttggggaaa     1320

gattttagga agaaagcaag gcagtccatt cagggaattc tggaggcagc cttcagtgag     1380

gagctcacac gttccaccca ctgtccctca aacaatgtca tttcagaaag aaatagtaca     1440

actgtgtga                                                             1449


<210>  1030
<211>  1488
<212>  DNA
<213>  Homo sapiens

<400>  1030
atggccacca ccgccacctg cacccgtttc accgacgact accagctctt cgaggagctt       60

ggcaagggtg ctttctctgt ggtccgcagg tgtgtgaaga aaacctccac gcaggagtac      120

gcagcaaaaa tcatcaatac caagaagttg tctgcccggg atcaccagaa actagaacgt      180

gaggctcgga tatgtcgact tctgaaacat ccaaacatcg tgcgcctcca tgacagtatt      240

tctgaagaag ggtttcacta cctcgtgttt gaccttgtta ccggcgggga gctgtttgaa      300

gacattgtgg ccagagagta ctacagtgaa gcagatgcca gccactgtat acatcagatt      360

ctggagagtg ttaaccacat ccaccagcat gacatcgtcc acagggacct gaagcctgag      420

aacctgctgc tggcgagtaa atgcaagggt gccgccgtca agctggctga ttttggccta      480

gccatcgaag tacagggaga gcagcaggct tggtttggtt ttgctggcac cccaggttac      540

ttgtcccctg aggtcttgag gaaagatccc tatggaaaac ctgtggatat ctgggcctgc      600

ggggtcatcc tgtatatcct cctggtgggc tatcctccct tctgggatga ggatcagcac      660

aagctgtatc agcagatcaa ggctggagcc tatgatttcc catcaccaga atgggacacg      720

gtaactcctg aagccaagaa cttgatcaac cagatgctga ccataaaccc agcaaagcgc      780

atcacggctg accaggctct caagcacccg tgggtctgtc aacgatccac ggtggcatcc      840

atgatgcatc gtcaggagac tgtggagtgt ttgcgcaagt tcaatgcccg gagaaaactg      900

aagggtgcca tcctcacgac catgcttgtc tccaggaact tctcagctgc caaaagccta      960

ttgaacaaga agtcggatgg cggtgtcaag gagccacaaa ccactgtggt acacaacgct     1020

acagatggga tcaagggctc cacagagagc tgcaacacca ccacagaaga tgaggacctc     1080

aaagtgcgaa aacaggagat cattaagatt acagaacagc tgattgaagc catcaacaat     1140

ggggactttg aggcctacac gaagatttgt gatccaggcc tcacttcctt tgagcctgag     1200

gcccttggta acctcgtgga ggggatggat ttccataagt tttactttga gaatctcctg     1260

tccaagaaca gcaagcctat ccataccacc atcctaaacc cacacgtcca cgtgattggg     1320

gaggacgcag cgtgcatcgc ctacatccgc ctcacccagt acatcgacgg gcagggtcgg     1380

cctcgcacca gccagtcaga agagacccgg gtctggcacc gtcgggatgg caagtggctc     1440

aatgtccact atcactgctc aggggcccct gccgcaccgc tgcagtga                  1488


<210>  1031
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  1031
atggagctgc tgtgttgcga aggcacccgg cacgcgcccc gggccgggcc ggacccgcgg       60

ctgctggggg accagcgtgt cctgcagagc ctgctccgcc tggaggagcg ctacgtaccc      120

cgcgcctcct acttccagtg cgtgcagcgg gagatcaagc cgcacatgcg gaagatgctg      180

gcttactgga tgctggaggt atgtgaggag cagcgctgtg aggaggaagt cttccccctg      240

gccatgaact acctggatcg ctacctgtct tgcgtcccca cccgaaaggc gcagttgcag      300

ctcctgggtg cggtctgcat gctgctggcc tccaagctgc gcgagaccac gcccctgacc      360

atcgaaaaac tgtgcatcta caccgaccac gctgtctctc cccgccagtt gcgggactgg      420

gaggtgctgg tcctagggaa gctcaagtgg gacctggctg ctgtgattgc acatgatttc      480

ctggccttca ttctgcaccg gctctctctg ccccgtgacc gacaggcctt ggtcaaaaag      540

catgcccaga cctttttggc cctctgtgct acagattata cctttgccat gtacccgcca      600

tccatgatcg ccacgggcag cattggggct gcagtgcaag gcctgggtgc ctgctccatg      660

tccggggatg agctcacaga gctgctggca gggatcactg gcactgaagt ggactgcctg      720

cgggcctgtc aggagcagat cgaagctgca ctcagggaga gcctcaggga agcctctcag      780

accagctcca gcccagcgcc caaagccccc cggggctcca gcagccaagg gcccagccag      840

accagcactc ctacagatgt cacagccata cacctgtag                             879


<210>  1032
<211>  1137
<212>  DNA
<213>  Homo sapiens

<400>  1032
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  1033
<211>  186
<212>  DNA
<213>  Homo sapiens

<400>  1033
atgaagcgct tcctcttcct cctactcacc atcagcctcc tggttatggt acagatacaa       60

actggactct caggacaaaa cgacaccagc caaaccagca gcccctcagc atccagcaac      120

ataagcggag gcattttcct tttcttcgtg gccaatgcca taatccacct cttctgcttc      180

agttga                                                                 186


<210>  1034
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  1034
atgaccgtcg cgcggccgag cgtgcccgcg gcgctgcccc tcctcgggga gctgccccgg       60

ctgctgctgc tggtgctgtt gtgcctgccg gccgtgtggg gtgactgtgg ccttccccca      120

gatgtaccta atgcccagcc agctttggaa ggccgtacaa gttttcccga ggatactgta      180

ataacgtaca aatgtgaaga aagctttgtg aaaattcctg gcgagaagga ctcagtgatc      240

tgccttaagg gcagtcaatg gtcagatatt gaagagttct gcaatcgtag ctgcgaggtg      300

ccaacaaggc taaattctgc atccctcaaa cagccttata tcactcagaa ttattttcca      360

gtcggtactg ttgtggaata tgagtgccgt ccaggttaca gaagagaacc ttctctatca      420

ccaaaactaa cttgccttca gaatttaaaa tggtccacag cagtcgaatt ttgtaaaaag      480

aaatcatgcc ctaatccggg agaaatacga aatggtcaga ttgatgtacc aggtggcata      540

ttatttggtg caaccatctc cttctcatgt aacacagggt acaaattatt tggctcgact      600

tctagttttt gtcttatttc aggcagctct gtccagtgga gtgacccgtt gccagagtgc      660

agagaaattt attgtccagc accaccacaa attgacaatg gaataattca aggggaacgt      720

gaccattatg gatatagaca gtctgtaacg tatgcatgta ataaaggatt caccatgatt      780

ggagagcact ctatttattg tactgtgaat aatgatgaag gagagtggag tggcccacca      840

cctgaatgca gaggaaaatc tctaacttcc aaggtcccac caacagttca gaaacctacc      900

acagtaaatg ttccaactac agaagtctca ccaacttctc agaaaaccac cacaaaaacc      960

accacaccaa atgctcaagc aacacggagt acacctgttt ccaggacaac caagcatttt     1020

catgaaacaa ccccaaataa aggaagtgga accacttcag gtactacccg tcttctatct     1080

gggcacacgt gtttcacgtt gacaggtttg cttgggacgc tagtaaccat gggcttgctg     1140

acttag                                                                1146


<210>  1035
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  1035
atggcggtgg aaggaggaat gaaatgtgtg aagttcttgc tctacgtcct cctgctggcc       60

ttttgcgcct gtgcagtggg actgattgcc gtgggtgtcg gggcacagct tgtcctgagt      120

cagaccataa tccagggggc tacccctggc tctctgttgc cagtggtcat catcgcagtg      180

ggtgtcttcc tcttcctggt ggcttttgtg ggctgctgcg gggcctgcaa ggagaactat      240

tgtcttatga tcacgtttgc catctttctg tctcttatca tgttggtgga ggtggccgca      300

gccattgctg gctatgtgtt tagagataag gtgatgtcag agtttaataa caacttccgg      360

cagcagatgg agaattaccc gaaaaacaac cacactgctt cgatcctgga caggatgcag      420

gcagatttta agtgctgtgg ggctgctaac tacacagatt gggagaaaat cccttccatg      480

tcgaagaacc gagtccccga ctcctgctgc attaatgtta ctgtgggctg tgggattaat      540

ttcaacgaga aggcgatcca taaggagggc tgtgtggaga agattggggg ctggctgagg      600

aaaaatgtgc tggtggtagc tgcagcagcc cttggaattg cttttgtcga ggttttggga      660

attgtctttg cctgctgcct cgtgaagagt atcagaagtg gctacgaggt gatgtag         717


<210>  1036
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  1036
atgcaacgcc tggtggcctg ggacccagca tgtctccccc tgccgccgcc gccgcctgcc       60

tttaaatcca tggaagtggc caacttctac tacgaggcgg actgcttggc tgctgcgtac      120

ggcggcaagg cggcccccgc ggcgcccccc gcggccagac ccgggccgcg cccccccgcc      180

ggcgagctgg gcagcatcgg cgaccacgag cgcgccatcg acttcagccc gtacctggag      240

ccgctgggcg cgccgcaggc cccggcgccc gccacggcca cggacacctt cgaggcggct      300

ccgcccgcgc ccgcccccgc gcccgcctcc tccgggcagc accacgactt cctctccgac      360

ctcttctccg acgactacgg gggcaagaac tgcaagaagc cggccgagta cggctacgtg      420

agcctggggc gcctgggggc cgccaagggc gcgctgcacc ccggctgctt cgcgcccctg      480

cacccaccgc ccccgccgcc gccgccgccc gccgagctca aggcggagcc gggcttcgag      540

cccgcggact gcaagcggaa ggaggaggcc ggggcgccgg gcggcggcgc aggcatggcg      600

gcgggcttcc cgtacgcgct gcgcgcttac ctcggctacc aggcggtgcc gagcggcagc      660

agcgggagcc tctccacgtc ctcctcgtcc agcccgcccg gcacgccgag ccccgctgac      720

gccaaggcgc ccccgaccgc ctgctacgcg ggggccgcgc cggcgccctc gcaggtcaag      780

agcaaggcca agaagaccgt ggacaagcac agcgacgagt acaagatccg gcgcgagcgc      840

aacaacatcg ccgtgcgcaa gagccgcgac aaggccaaga tgcgcaacct ggagacgcag      900

cacaaggtcc tggagctcac ggccgagaac gagcggctgc agaagaaggt ggagcagctg      960

tcgcgcgagc tcagcaccct gcggaacttg ttcaagcagc tgcccgagcc cctgctcgcc     1020

tcctccggcc actgctag                                                   1038


<210>  1037
<211>  7614
<212>  DNA
<213>  Homo sapiens

<400>  1037
atggaagatt ttcgaggtat agcagaagaa tcatttccaa gctttctcac caattcatta       60

tttggtaaca gtgggatttt ggaaaatgtc actctttctt caaatcttgg cttgcctgtt      120

gctgtttcta cacttgctag ggatagatcc agcactgata acaggtatcc tgatatccag      180

gcatcttact tagtagaagg gagattttca gttccatccg ggtcatctcc cggaagccag      240

agtgatgctg aaccaagaga gaggttacag cttagcttcc aggatgatga ttctatctct      300

aggaaaaaga gctatgtgga aagtcaacgt ttgtcaaatg ctctcagcaa acagtcagct      360

ttacaaatgg agacagcagg accagaagag gagccagccg gagctacaga atccttgcag      420

ggccaagatc tcttcaacag ggcttcacca ctggaacaag cacaagactc acctattgat      480

tttcatttac agtcatggat gaataataag gaacccaaga ttgttgtgct tgatgctgga      540

aaacattttg aagacaagac tctaaagagt gacctaagcc acactagctt attagaaaat      600

gagaaactta tcttaccgac aagcttggaa gattcttctg atgatgatat tgatgatgaa      660

atgttttatg atgatcattt ggaggcttat tttgaacaac tggcaattcc aggaatgata      720

tatgaagacc tagaaggacc agaacctcca gaaaaaggtt ttaagttacc tacaaatggt      780

cttagacagg caaatgaaaa cggtagctta aactgcaagt ttcaatcaga aaataacagc      840

tctctgattt ccctcgactc acactcttct gaaacaactc acaaagagtc tgaggaaagc      900

caagttattt gtctacctgg gactagtaat tctataggta ctggagatag tagaaggtac      960

acagatggta tgttaccatt ttcctctggt acttggggaa ctgagaaaga aatagaaaat     1020

ttgaagggta ttgttccaga tcttaacagt gaatgtgcaa gtaaagatgt tctggtgaag     1080

accctcaggg ctattgatgt gaaacttaac tctgataatt ttcatgatgc aaatgccaat     1140

agaggtggtt ttgatctgac tgaccctgta aaacaggggg cagagtgtcc tcaccaaaat     1200

aagacagttt tgcacatgga tggatgttta gacactgaga ctcctacggt gtccattcaa     1260

gaaaatgtgg atgtagcctc tttgaagccc attagtgaca gtggaattaa tttcactgat     1320

gccatttggt caccaacttg tgaaaggcga acatgtgaat gtcacgagtc catcgaaaag     1380

aataaagaca aaacagatct cccacagagt gtggtctatc aaaatgaaga gggtaggtgg     1440

gtcacagacc ttgcctatta cacatctttt aatagcaaac aaaatttaaa tgtgtctcta     1500

agtgatgaga tgaatgaaga cttcagatct ggttctgaag catttgattt gattgcacaa     1560

gatgaagaag aatttaataa agagcatcaa tttatacagg aagaaaacat agatgctcat     1620

aatacttcgg ttgcactggg cgatacgtcc tggggagcta caattaatta cagtctgttg     1680

aggaaatcac gtagcacatc agatttggat aaagatgatg ccagttattt acgtctgtct     1740

ttaggagagt tctttgctca aagatctgaa gctcttggtt gccttggtgg tggtaacaat     1800

gtgaaaagac catcatttgg ctattttatt agatcaccag agaagagaga acctattgcc     1860

ttaataagaa aatctgatgt atcaagaggt aatttggaaa aagaaatggc tcatcttaac     1920

catgatctat attcaggaga tttaaatgaa cagtcccagg cacagctaag tgaaggatca     1980

attacacttc aggttgaagc agtagagagt acttcacaag tggatgaaaa tgatgtgacg     2040

ttaacggctg ataaaggcaa aacagaggac actttcttca tgagcaacaa accccaaaga     2100

tacaaagaca agctaccaga tagtggtgat tctatgctta ggatcagcac cattgcttca     2160

gccattgcag aggcatcagt taatactgat ccttcccaac ttgctgcaat gatcaaggca     2220

ctttcaaata aaaccagaga caagactttt caggaagatg agaaacaaaa ggactattct     2280

catgtgcgtc atttcttacc taatgattta gaaaaaagta atggatccaa tgcacttgat     2340

atggagaaat accttaaaaa aacagaagtt agtagatatg aaagtgcatt ggaaaacttt     2400

tcaagggcta gtatgtctga tacttgggat ttatctttgc ccaaagaaca aactactcaa     2460

gacattcatc cggtggactt aagtgctact agtgtaagtg tgagggcacc agaagaaaac     2520

acagcagcta ttgtttatgt tgaaaatgga gagagtgaga atcaagagtc atttagaacc     2580

ataaactcct caaattcagt tacaaataga gagaataaca gtgcagtagt tgatgtgaag     2640

acatgttcca ttgacaacaa attacaagat gttggtaacg atgaaaaagc tacctcaatt     2700

tccactccat ctgatagtta ttcatcagtg aggaacccca gaataacatc cctttgtctg     2760

ttaaaagact gtgaagaaat acgagataac agagaaaatc agaggcaaaa tgagtgtgtc     2820

agtgaaataa gcaacagtga gaagcatgtg acttttgaaa accatcgcat agtctcacct     2880

aaaaatagtg atttgaaaaa tacctctcct gagcatggtg gacgtggctc agaggatgag     2940

caggagagct tcagaccttc cacgtcacca ctgagtcatt cttctcctag tgaaatttct     3000

ggaacgagtt catcagggtg tgcgttagag tcctttggtt cagcagctca gcagcagcag     3060

cctccctgtg agcaggagtt gtctcccttg gtgtgctcgc ctgctggggt gagcaggctg     3120

acgtatgtgt ctgaaccaga gagctcctat cctaccacag ccacagatga tgccctggag     3180

gaccgcaaga gtgatatcac cagcgagttg agtaccacaa ttattcaagg cagtccagcc     3240

gcattggagg aacgggctat ggaaaaattg agagaaaaag ttccatttca gaatagagga     3300

aaaggaacat tatcatctat tatccagaat aactctgata caagaaaagc aactgaaact     3360

acttctctga gtagcaagcc tgaatatgta aaacctgact ttagatggag taaagatcct     3420

tcctccaaaa gtggaaatct gttggaaacc agtgaggtag gttggacatc aaaccctgag     3480

gaattggacc cgatcaggct ggctctcctg ggcaagtcag gtctgagctg tcaggtgggg     3540

tcagccacat cacaccctgt gtcctgccag gagcctatag atgaagatca aagaataagt     3600

cctaaagata agtcaactgc tggccgtgag ttcagtggcc aggtttctca tcagaccacc     3660

tctgaaaacc agtgtactcc tattcccagc agcacagttc acagctctgt ggctgacatg     3720

cagaacatgc ctgctgctgt gcacgcactc ttgacacaac cctctctcag cgctgctcct     3780

tttgctcagc ggtatttggg aacactccct tcaactggaa gcaccacctt gcctcagtgc     3840

catgctggca atgccacagt ctgtggcttc tcaggaggcc ttccctatcc agctgttgca     3900

ggagagcctg tgcagaactc tgtggctgtg ggaatttgtc taggatcaaa tatcggctct     3960

ggatggatgg gtacctcttc cctctgtaac ccatattcta ataccttaaa tcagaacctg     4020

ctaagcacaa caaaaccttt tcctgtgccg tctgttggta caaactgtgg aattgaacca     4080

tgggattcag gagtgacatc aggattgggg agtgtccgag tgcccgagga gttgaagctt     4140

cctcatgctt gctgtgtcgg gatcgcttcc cagaccctcc tcagtgtgct taatccaact     4200

gaccgctggc tgcaagtcag cattggggtc ctcagcatta gtgttaatgg tgaaaaggtg     4260

gatctttcaa catatcgttg tttagttttc aagaataaag ccatcataag acctcatgcc     4320

acagaagaga taaaagtgct ttttatacca tccagtcctg gggttttcag atgcacattc     4380

agtgttgctt cttggccatg ttcgacagat gctgagacca tcgtacaggc agaagctttg     4440

gccagcaccg tcactctcac tgccattgcc gagagtcctg ttattgaggt agaaacagaa     4500

aagaaagacg ttcttgattt tggtgacttg acttatggag gctggaaagc cctcccacta     4560

aaattgataa accgaacgca tgccactgtg ccaattagac tgattattaa tgctaacgct     4620

gtagcctggc gctgtttcac gttttccaag gaatccgtcc gagctcctgt ggaagttgct     4680

ccttgcgctg atgtggtcac tcggctagca ggcccttctg tggtcaacca catgatgcct     4740

gctagttatg atggacagga tccagaattt ctgatgattt gggttctttt ccatagtcca     4800

aagaaacaga tcagctcttc agatattctg gactcagcag aagaattctc ggcaaaagtt     4860

gatatcgaag ttgacagccc aaaccctacg cccgttctta gaagtgtgag tctccgagca     4920

agagcaggaa tagctaggat ccatgctccc agggacttgc agacgatgca tttcttggcc     4980

aaagtggctt cctcaagaaa gcagcactta cctttgaaaa atgctgggaa cattgaagtt     5040

tatttggata tcaaggtccc agaacaagga agtcactttt cagtggatcc aaagaatcta     5100

ctccttaaac ctggagaaga acatgaggtt attgtttcat ttactccaaa ggatcctgaa     5160

gcctgcgagg aaaggatctt gaaaatattt gtgcagccat ttggacctca gtatgaggta     5220

gtgttaaaag gcgaagtcat ttcttcagga agtaaacctc tgtcacctgg accttgctta     5280

gatattccat cgattttgtc caacaaacaa tttctggctt ggggaggagt ccctctaggt     5340

agaacacagc ttcagaaact agctttaaga aataattctg catctacaac tcaacattta     5400

cgactgctta ttagaggaca agatcaggac tgctttcagc ttcagaacac ttttggttca     5460

gaacagcgat tgaccagtaa ctgtgagatc agaattcacc caaaggaaga cattttcatc     5520

tctgtattat ttgcacctac tcgattatct tgcatgttgg ctagactaga aatcaaacaa     5580

cttggaaatc gatcacaacc aggcattaag ttcacaatac ctttgtctgg atatggagga     5640

acaagcaatc ttattttgga aggcgttaaa aaattatctg acagttacat ggtaacagtg     5700

aatggcttag tacctggcaa agaaagtaaa attgtttttt ctgtccgcaa cactggctcc     5760

cgagcagctt ttgttaaagc agtaggtttt aaggattctc agaaaaaagt tttgctggat     5820

cctaaagtat tgaggatttt tccagataaa tttgtactca aggaaagaac acaagaaaat     5880

gttactttaa tatataatcc atcagacaga ggaatcaata ataaaactgc aacagaacta     5940

tcaactgtat acttatttgg tggagatgaa atttcaagac agcagtatcg cagggccctg     6000

ttacataaac cagagatgat aaaacagata cttccagaac atagtgtgct tcaaaacatt     6060

aattttgttg aagcatttca agatgagcta ttagtaactg aagtatatga tcttccccaa     6120

cgacctaatg atgttcagct cttttatgga agcatgtgta aaattatact ttcagtaatt     6180

ggagaattca gagattgcat ttctagcaga gaattccttc agccttcttc caaagctagc     6240

ttggaatcta caagcgactt gggagcttct gggaaacatg gtggcaacgt ctctttggat     6300

gttttaccag tcaaaggtcc tcagggttct cctcttctct cacgggcggc tcgcccgcct     6360

ctggatcagc tggcctccga agagccgtgg actgtcctac ccgagcactt gattctggta     6420

gctccttctc cttgtgacat ggcaaaaact ggacgtttcc agattgtgaa taactctgtg     6480

aggttactga gatttgagct gtgctggcca gcgcattgcc tcacagtcac gccgcagcat     6540

ggatgtgtcg cgccagagag taaactacaa attcttgtga gtcctaattc ctccttatcc     6600

acaaaacagt caatgttccc gtggagtggt ttgatctata tacactgtga cgatggacag     6660

aagaaaattg tgaaagttca aattcgagaa gatttaactc aagtggaact tttaactcgt     6720

ttgacctcca aaccatttgg aattctttcc ccagtatctg agccttcagt tagtcatttg     6780

gtcaaaccaa tgacaaaacc gccttccaca aaagttgaaa taagaaacaa gagtattact     6840

tttcctacaa cagaacctgg tgaaacttca gagagctgtc tagaactcga gaatcatggc     6900

accacagacg tgaaatggca tctgtcatct ttagcgccac cttatgtcaa gggagttgat     6960

gaaagtggag atgtttttag agctacctat gcagcattca gatgttctcc tatttctggt     7020

ctgctggaaa gccatgggat ccaaaaagtc tccatcacat ttttgcccag aggtaggggg     7080

gattatgccc agttttggga tgttgaatgt caccctctta aggagcctca catgaaacac     7140

acgttgagat tccaactctc tggacaaagc atcgaagcag aaaatgagcc tgaaaacgca     7200

tgcctttcca cggattccct cattaaaata gatcatttag ttaagccccg aagacaagct     7260

gtgtcagagg cttctgctcg catacctgag cagcttgatg tgactgctcg tggagtttat     7320

gccccagagg atgtgtacag gttccggccg actagtgtgg gggaatcacg gacacttaaa     7380

gtcaatctgc gaaataattc ttttattaca cactcactga agtttttgag tcccagagag     7440

ccattctatg tcaaacattc caagtactct ttgagagccc agcattacat caacatgccc     7500

gtgcagttca aaccgaagtc cgcaggcaaa tttgaagctt tgcttgtcat tcaaacagat     7560

gaaggcaaga gtattgctat tcgactaatt ggtgaagctc ttggaaaaaa ttaa           7614


<210>  1038
<211>  1407
<212>  DNA
<213>  Homo sapiens

<400>  1038
atggcagcgt ccagcaactc cagcctgtcc ggctcgtcgg tgtcctccga tgctgaagaa       60

taccagcctc ctatatggaa atcatactta tatcagttac agcaagaggc acctcgtccc      120

aagagaatca tttgtcctcg ggaggtggaa aacagaccaa aatattatgg aagagagttt      180

catgggatca tctctcggga gcaggcggat gagcttcttg gaggcgtgga gggtgcctac      240

atccttagag aaagccagcg gcaaccagga tgctacacgc tggctctcag gtttggaaac      300

cagaccttaa actacaggct cttccacgac gggaaacact ttgtgggtga gaagaggttt      360

gagtcgattc atgatctggt gacagatggc ttgataacac tgtacataga aacaaaagct      420

gccgagtaca tttcaaaaat gacaactaac cccatctatg aacacattgg atatgccacc      480

ctactcagag aaaaagtatc cagaaggctg agcaggtcta aaaatgaacc aagaaaaaca      540

aacgtcacac atgaagaaca cacagcggtg gaaaagatct cctccctggt tcgaagggct      600

gccctcacac acaacgacaa ccacttcaat tatgagaaga cacacaactt taaggtccac      660

acgttccgag gcccacactg gtgtgaatat tgtgccaatt tcatgtgggg gctcatcgcc      720

caaggggtcc ggtgctcaga ctgtggattg aacgtacaca aacagtgttc caagcacgtt      780

cccaatgact gccaacctga tctcaagagg atcaagaaag tgtactgttg tgacctcaca      840

acacttgtga aggctcacaa cactcagaga cccatggtgg tagacatatg cattcgggaa      900

attgaagcaa gaggattaaa atcggaaggc ctttacagag tctctgggtt cactgaacac      960

attgaagatg tcaaaatggc atttgacaga gatggtgaaa aggccgatat atctgccaat     1020

gtctatccag acataaacat catcactgga gcccttaaac tgtatttcag agacttaccc     1080

atccctgtca tcacatatga tacctattcc aaatttatag atgcagcaaa aatctccaat     1140

gcagatgaga ggctggaagc cgtccatgaa gtgctgatgc tgctgcctcc tgcccactat     1200

gaaaccctcc ggtacctaat gatccacctc aaaaaggtta ctatgaatga aaaagacaat     1260

ttcatgaatg cagaaaatct ggggatcgtg tttgggccca ctctgatgag gccccctgag     1320

gacagcaccc tgaccaccct gcatgatatg cggtaccaaa agctgattgt gcagatttta     1380

atagaaaacg aagacgtttt attctaa                                         1407


<210>  1039
<211>  2118
<212>  DNA
<213>  Homo sapiens

<400>  1039
atgaccatag aggaccttcc agattttcca ttagaaggaa atcctttgtt tggaagatac       60

ccatttatat tttctgcttc tgatacccca gttatctttt ccatttctgc agcaccaatg      120

ccttcagact gtgaattttc tttctttgat cctaatgatg catcatgcca ggaaattctt      180

tttgatccca aaacttcagt ttcagaatta tttgccattt tgagacagtg ggttcctcag      240

gtccaacaaa acattgacat tattggaaat gagattctta agagaggttg caatgtgaat      300

gatagagatg gattgacaga tatgactctt ttacattata cctgcaaatc tggagctcat      360

ggtattggtg atgtggaaac agctgtaaaa tttgcaactc agcttattga cctgggagca      420

gacattagtt tgcggagtcg ctggacaaac atgaatgctt tgcattatgc tgcttatttt      480

gatgtccctg aacttataag agtgattttg aaaacatcga aaccaaaaga tgtggatgcc      540

acttgcagtg attttaattt tggaacagct ttgcatattg cagcatacaa cttgtgtgca      600

ggtgctgtga agtgcctctt ggagcaggga gcaaatcctg catttaggaa tgacaaagga      660

cagatccctg ctgatgttgt tccagaccca gtagatatgc cgttagagat ggctgacgcc      720

gcagccactg ctaaggaaat caagcagatg cttctagatg cggtgcctct gtcatgtaac      780

atctcaaagg ccatgctccc aaattatgat catgtcactg gcaaggcaat gcttacgtca      840

cttggcctga agttggggga tcgtgttgtt attgcaggac agaaggttgg tacattaaga      900

ttttgtggaa caactgaatt tgcaagtggg cagtgggctg gcattgaact ggatgaacca      960

gaaggaaaaa ataatggaag tgttggaaaa gtccagtact ttaaatgtgc ccccaagtat     1020

ggtatttttg cacctctttc aaagataagt aaagcaaaag gtcgaaggaa gaatataaca     1080

cacactcctt ctacaaaagc tgctgtacct ctcatcaggt cccagaaaat tgacgtagct     1140

catgtgacgt caaaagtaaa tactggatta atgacatcaa aaaaagatag tgcttctgag     1200

tcaacacttt cattgcctcc tggtgaagaa cttaaaactg tgacagagaa agatgttgcc     1260

ctgcttggat ctgtcagcag ctgctcctct acatcttctt tggaacacag acagagctac     1320

cccaagaaac agaatgcaat cagcagtaac aagaagacaa tgagcaaaag cccttccctt     1380

tcatccagag ccagtgctgg tttgaattcc tcagcaacat ctacagcaaa taatagccgt     1440

tgcgaggggg aactccgcct cggagagaga gtgttagtgg taggacagag actgggcacc     1500

attaggttct ttgggacaac aaacttcgct ccaggatatt ggtatggtat agagcttgaa     1560

aaaccccatg gcaagaatga tggttcagtt ggaggtgtgc agtattttag ctgttctcca     1620

agatatggaa tatttgctcc cccatccagg gtgcaaagag taacagattc cctggatacc     1680

ctttcagaaa tttcttcaaa taaacagaac cattcttatc ctggttttag gagaagtttt     1740

agcacaactt ctgcttcttc ccaaaaggag attaacagaa gaaatgcttt ttccaaatcg     1800

aaagctgctt tgcgtcgcag ttggagcagc acccccaccg caggtggcat tgaagggagc     1860

gtgaagctgc acgaggggtc tcaggtcctg ctcacgagct ccaatgagat gggtactgtt     1920

aggtatgtgg gccccactga ctttgcttca ggtatctggc ttggacttga gctccgaagc     1980

gccaagggaa aaaatgatgg gtcagtgggt gacaagcgct atttcacctg taagccgaac     2040

catggagtct tagttcgacc gagcagagtg acctatcggg gaattaatgg gtcaaaactt     2100

gtggatgaga attgttaa                                                   2118


<210>  1040
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  1040
atgccagcgg caactgtaga tcatagccaa agaatttgtg aagtttgggc ttgcaacttg       60

gatgaagaga tgaagaaaat tcgtcaagtt atccgaaaat ataattacgt tgctatggac      120

accgagtttc caggtgtggt tgcaagaccc attggagaat tcaggagcaa tgctgactat      180

caataccaac tattgcggtg taatgtagac ttgttaaaga taattcagct aggactgaca      240

tttatgaatg agcaaggaga ataccctcca ggaacttcaa cttggcagtt taattttaaa      300

tttaatttga cggaggacat gtatgcccag gactctatag agctactaac aacatctggt      360

atccagttta aaaaacatga ggaggaagga attgaaaccc agtactttgc agaacttctt      420

atgacttctg gagtggtcct ctgtgaaggg gtcaaatggt tgtcatttca tagcggttac      480

gactttggct acttaatcaa aatcctaacc aactctaact tgcctgaaga agaacttgac      540

ttctttgaga tccttcgatt gttttttcct gtcatttatg atgtgaagta cctcatgaag      600

agctgcaaaa atctcaaagg tggattacag gaggtggcag aacagttaga gctggaacgg      660

ataggaccac aacatcaggc aggatctgat tcattgctca caggaatggc ctttttcaaa      720

atgagagaaa tgttctttga agatcatatt gatgatgcca aatattgtgg tcatttgtat      780

ggccttggtt ctggttcatc ctatgtacag aatggcacag ggaatgcata tgaagaggaa      840

gccaacaagc agtcatga                                                    858


<210>  1041
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  1041
atggattttg acaagaaagg agggaaaggg gagacggagg agggccggag aatgtccaag       60

gccggcgggg gccggagcag ccacggcatc cggagctcgg ggaccagctc gggggtcctg      120

atggtgggcc ccaacttccg cgtcggcaag aagatcggct gcggcaactt cggggagctc      180

cgcctaggaa agaatctcta tacaaatgaa tacgtggcta tcaaattgga gccgatcaag      240

tcccgggccc cgcagctgca cctggagtac cggttctaca agcagctcag cgccacagag      300

ggcgtccctc aggtctacta cttcggtccg tgcgggaagt acaacgccat ggtgctggag      360

ctgctggggc ccagcctgga ggacctgttc gacctgtgcg accggacctt cacgctcaag      420

acggtgctga tgatcgccat ccagctgatc acgcgcatgg agtatgtgca caccaagagc      480

ctaatctacc gggacgtgaa gcccgagaac ttcctggtgg gccgcccggg gaccaagcgg      540

cagcatgcca tccacatcat cgacttcggg ctggccaagg agtacatcga ccccgagacc      600

aagaagcaca tcccgtaccg cgagcacaag agcctgacgg gcacggcgcg ctacatgagc      660

atcaacacgc acctgggcaa ggagcagagc cgccgcgacg acctggaggc gctgggccac      720

atgttcatgt acttcctgcg cggcagcctc ccctggcagg ggctcaaggc cgacacgctc      780

aaggagcggt accagaagat cggggacacc aaacgcgcca cgcccatcga ggtgctctgc      840

gagaacttcc cagaggagat ggccacgtac ctgcgctatg tgcggcgcct ggacttcttc      900

gagaagcccg actatgacta cctgcggaag ctcttcaccg acctcttcga ccgcagtggc      960

ttcgtgttcg actatgagta cgactgggcc gggaagcccc tgccgacccc catcggcacc     1020

gtccacaccg acctgccctc ccagcctcag ctccgggaca aaacccagcc gcacagcaaa     1080

aaccaggcgt tgaactccac caacggggag ctgaatgcgg acgaccccac ggccggccac     1140

tccaacgccc cgatcacagc gcctgcagag gtggaggtgg ccgatgaaac caaatgctgc     1200

tgtttcttca agaggagaaa gagaaaatcg ctgcagcgac acaagtga                  1248


<210>  1042
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  1042
atgatgtgcg gggcgccctc cgccacgcag ccggccaccg ccgagaccca gcacatcgcc       60

gaccaggtga ggtcccagct tgaagagaaa gaaaacaaga agttccctgt gtttaaggcc      120

gtgtcattca agagccaggt ggtcgcgggg acaaactact tcatcaaggt gcacgtcggc      180

gacgaggact tcgtacacct gcgagtgttc caatctctcc ctcatgaaaa caagcccttg      240

accttatcta actaccagac caacaaagcc aagcatgatg agctgaccta tttctga         297


<210>  1043
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  1043
atgggagtct ggttaaataa agatgactat atcagagact tgaaaaggat cattctctgt       60

tttctgatag tgtatatggc cattttagtg ggcacagatc aggattttta cagtttactt      120

ggagtgtcca aaactgcaag cagtagagaa ataagacaag ctttcaagaa attggcattg      180

aagttacatc ctgataaaaa cccgaataac ccaaatgcac atggcgattt tttaaaaata      240

aatagagcat atgaagtact caaagatgaa gatctacgga aaaagtatga caaatatgga      300

gaaaagggac ttgaggataa tcaaggtggc cagtatgaaa gctggaacta ttatcgttat      360

gattttggta tttatgatga tgatcctgaa atcataacat tggaaagaag agaatttgat      420

gctgctgtta attctggaga actgtggttt gtaaattttt actccccagg ctgttcacac      480

tgccatgatt tagctcccac atggagagac tttgctaaag aagtggatgg gttacttcga      540

attggagctg ttaactgtgg tgatgataga atgctttgcc gaatgaaagg agtcaacagc      600

tatcccagcc tcttcatttt tcggtctgga atggccccag tgaaatatca tggagacaga      660

tcaaaggaga gtttagtgag ttttgcaatg cagcatgtta gaagtacagt gacagaactt      720

tggacaggaa attttgtcaa ctccatacaa actgcttttg ctgctggtat tggctggctg      780

atcacttttt gttcaaaagg aggagattgt ttgacttcac agacacgact caggcttagt      840

ggcatgttgg atggtcttgt taatgtagga tggatggact gtgccaccca ggataacctt      900

tgtaaaagct tagatattac aacaagtact actgcttatt ttcctcctgg agccacttta      960

aataacaaag agaaaaacag tattttgttt ctcaactcat tggatgctaa agaaatatat     1020

ttggaagtaa tacataatct tccagatttt gaactacttt cggcaaacac actagaggat     1080

cgtttggctc atcatcggtg gctgttattt tttcattttg gaaaaaatga aaattcaaat     1140

gatcctgagc tgaaaaaact aaaaactcta cttaaaaatg atcatattca agttggcagg     1200

tttgactgtt cctctgcacc agacatctgt agtaatctgt atgtttttca gccgtctcta     1260

gcagtattta aaggacaagg aaccaaagaa tatgaaattc atcatggaaa gaagattcta     1320

tatgatatac ttgcctttgc caaagaaagt gtgaattctc atgttaccac gcttggacct     1380

caaaattttc ctgccaatga caaagaacca tggcttgttg atttctttgc cccctggtgt     1440

ccaccatgtc gagctttact accagagtta cgaagagcat caaatcttct ttatggtcag     1500

cttaagtttg gtacactaga ttgtacagtt catgagggac tctgtaacat gtataacatt     1560

caggcttatc caacaacagt ggtattcaac cagtccaaca ttcatgagta tgaaggacat     1620

cactctgctg aacaaatctt ggagttcata gaggatctta tgaatccttc agtggtctcc     1680

cttacaccca ccaccttcaa cgaactagtt acacaaagaa aacacaacga agtctggatg     1740

gttgatttct attctccgtg gtgtcatcct tgccaagtct taatgccaga atggaaaaga     1800

atggcccgga cattaactgg actgatcaac gtgggcagta tagattgcca acagtatcat     1860

tctttttgtg cccaggaaaa cgttcaaaga taccctgaga taagattttt tcccccaaaa     1920

tcaaataaag cttatcatta tcacagttac aatggttgga atagggatgc ttattccctg     1980

agaatctggg gtctaggatt tttacctcaa gtatccacag atctaacacc tcagactttc     2040

agtgaaaaag ttctacaagg gaaaaatcat tgggtgattg atttctatgc tccttggtgt     2100

ggaccttgcc agaattttgc tccagaattt gagctcttgg ctaggatgat taaaggaaaa     2160

gtgaaagctg gaaaagtaga ctgtcaggct tatgctcaga catgccagaa agctgggatc     2220

agggcctatc caactgttaa attttatttc tacgaaagag caaagagaaa ttttcaagaa     2280

gagcagataa ataccagaga tgcaaaagca atcgctgcct taataagtga aaaattggaa     2340

actctccgaa atcaaggcaa gaggaataag gatgaacttt ga                        2382


<210>  1044
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  1044
atgtctattc tcaagatcca tgccagggag atctttgact ctcgcgggaa tcccactgtt       60

gaggttgatc tcttcacctc aaaaggtctc ttcagagctg ctgtgcccag tggtgcttca      120

actggtatct atgaggccct agagctccgg gacaatgata agactcgcta tatggggaag      180

ggtgtctcaa aggctgttga gcacatcaat aaaactattg cgcctgccct ggttagcaag      240

aaactgaacg tcacagaaca agagaagatt gacaaactga tgatcgagat ggatggaaca      300

gaaaataaat ctaagtttgg tgcgaacgcc attctggggg tgtcccttgc cgtctgcaaa      360

gctggtgccg ttgagaaggg ggtccccctg taccgccaca tcgctgactt ggctggcaac      420

tctgaagtca tcctgccagt cccggcgttc aatgtcatca atggcggttc tcatgctggc      480

aacaagctgg ccatgcagga gttcatgatc ctcccagtcg gtgcagcaaa cttcagggaa      540

gccatgcgca ttggagcaga ggtttaccac aacctgaaga atgtcatcaa ggagaaatat      600

gggaaagatg ccaccaatgt gggggatgaa ggcgggtttg ctcccaacat cctggagaat      660

aaagaaggcc tggagctgct gaagactgct attgggaaag ctggctacac tgataaggtg      720

gtcatcggca tggacgtagc ggcctccgag ttcttcaggt ctgggaagta tgacctggac      780

ttcaagtctc ccgatgaccc cagcaggtac atctcgcctg accagctggc tgacctgtac      840

aagtccttca tcaaggacta cccagtggtg tctatcgaag atccctttga ccaggatgac      900

tggggagctt ggcagaagtt cacagccagt gcaggaatcc aggtagtggg ggatgatctc      960

acagtgacca acccaaagag gatcgccaag gccgtgaacg agaagtcctg caactgcctc     1020

ctgctcaaag tcaaccagat tggctccgtg accgagtctc ttcaggcgtg caagctggcc     1080

caggccaatg gttggggcgt catggtgtct catcgttcgg gggagactga agataccttc     1140

atcgctgacc tggttgtggg gctgtgcact gggcagatca agactggtgc cccttgccga     1200

tctgagcgct tggccaagta caaccagctc ctcagaattg aagaggagct gggcagcaag     1260

gctaagtttg ccggcaggaa cttcagaaac cccttggcca agtaa                     1305


<210>  1045
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  1045
atgaatatga ctcaagcccg ggttctggtg gctgcagtgg tggggttggt ggctgtcctg       60

ctctacgcct ccatccacaa gattgaggag ggccatctgg ctgtgtacta caggggagga      120

gctttactaa ctagccccag tggaccaggc tatcatatca tgttgccttt cattactacg      180

ttcagatctg tgcagacaac actacaaact gatgaagtta aaaatgtgcc ttgtggaaca      240

agtggtgggg tcatgatcta tattgaccga atagaagtgg ttaatatgtt ggctccttat      300

gcagtgtttg atatcgtgag gaactatact gcagattatg acaagacctt aatcttcaat      360

aaaatccacc atgagctgaa ccagttctgc agtgcccaca cacttcagga agtttacatt      420

gaattgtttg atcaaataga tgaaaacctg aagcaagctc tgcagaaaga cttaaacctc      480

atggccccag gtctcactat acaggctgtg cgtgttacaa aacccaaaat cccagaagcc      540

ataagaagaa attttgagtt aatggaggct gagaagacaa aactccttat agctgcacag      600

aaacaaaagg ttgtggaaaa agaagctgag acagagagga aaaaggcagt tatagaagca      660

gagaagattg cacaagtggc aaaaattcgg tttcagcaga aagtgatgga aaaagaaact      720

gaaaagcgca tttctgaaat cgaagatgct gcattcctgg cccgagagaa agcgaaagca      780

gatgctgaat attatgctgc acacaaatat gccacctcaa acaagcacaa gttgaccccg      840

gaatatctgg agctcaaaaa gtaccaggcc attgcttcta acagtaagat ctattttggc      900

agcaacatcc ctaacatgtt cgtggactcc tcatgtgctt tgaaatattc agatattagg      960

actggaagag aaagctcact cccctctaag gaggctcttg aaccctctgg agagaacgtc     1020

atccaaaaca aagagagcac aggttga                                         1047


<210>  1046
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  1046
atgtctgaga ctcctgctca gtgtagcatt aagcaggaac gaatttcata tacacctcca       60

gagagcccag tgccgagtta cgcttcctcg acgccacttc atgttccagt gcctcgagcg      120

ctcaggatgg aggaagactc gatccgcctg cctgcgcacc tgcgcttgca gccaatttac      180

tggagcaggg atgacgtagc ccagtggctc aagtgggctg aaaatgagtt ttctttaagg      240

ccaattgaca gcaacacgtt tgaaatgaat ggcaaagctc tcctgctgct gaccaaagag      300

gactttcgct atcgatctcc tcattcaggt gatgtgctct atgaactcct tcagcatatt      360

ctgaagcaga ggaaacctcg gattcttttt tcaccattct tccaccctgg aaactctata      420

cacacacagc cggaggtcat actgcatcag aaccatgaag aagataactg tgtccagagg      480

acccccaggc catccgtgga taatgtgcac cataaccctc ccaccattga actgttgcac      540

cgctccaggt cacctatcac gacaaatcac cggccttctc ctgaccccga gcagcggccc      600

ctccggtccc ccctggacaa catgatccgc cgcctctccc cggctgagag agctcaggga      660

cccaggccgc accaggagaa caaccaccag gagtcctacc ctctgtcagt gtctcccatg      720

gagaataatc actgcccagc gtcctccgag tcccacccga agccatccag cccccggcag      780

gagagcacac gcgtgatcca gctgatgccc agccccatca tgcaccctct gatcctgaac      840

ccccggcact ccgtggattt caaacagtcc aggctctccg aggacgggct gcatagggaa      900

gggaagccca tcaacctctc tcatcgggaa gacctggctt acatgaacca catcatggtc      960

tctgtctccc cgcctgaaga gcacgccatg cccattggga gaatagcaga ctgtagactg     1020

ctttgggatt acgtctatca gttgctttct gacagccggt acgaaaactt catccgatgg     1080

gaggacaaag aatccaaaat attccggata gtggatccca acggactggc tcgactgtgg     1140

ggaaaccata agaacagaac aaacatgacc tatgagaaaa tgtccagagc cctgcgccac     1200

tactacaaac taaacattat caggaaggag ccaggacaaa ggcttttgtt caggtttatg     1260

aaaaccccag atgaaatcat gagtggccga acagaccgtc tggagcacct agagtcccag     1320

gagctggatg aacaaatata ccaagaagat gaatgctga                            1359


<210>  1047
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  1047
atggcgccac ccagtacccg ggagcccagg gtcctgtcgg cgaccagcgc aaccaaatcc       60

gacggagaga tggtgctgcc aggcttcccg gacgccgaca gctttgtgaa gtttgctctt      120

gggtccgtgg tggcagtcac caaggcatct gggggcctac cacagtttgg cgatgagtat      180

gatttttacc gaagttttcc tggcttccaa gcattttgcg aaacacaggg agacaggttg      240

cttcagtgca tgagcagagt aatgcagtac catgggtgtc gcagcaacat taaggatcga      300

agtaaagtga ctgagctgga agacaagttt gatttactag ttgatgccaa tgatgtaatt      360

ctggagagag tgggtatttt actggatgaa gcctcaggtg taaacaagaa tcaacagcct      420

gtcctccctg ccggcttgca ggtccccaaa acggtagtgt ccagctggaa ccgtaaggca      480

gcagaatatg gcaaaaaagc aaaatctgaa actttccggc tgcttcatgc aaaaaatatc      540

atccgacctc agctcaagtt tcgagagaag attgacaatt ccaacacacc atttcttcct      600

aaaatcttca tcaaacccaa tgctcagaaa cctctccctc aagctctctc taaggaaagg      660

cgggaacgcc cacaggatcg tcctgaggac ttggacgtcc cccctgcact ggctgatttc      720

atccatcagc agagaaccca gcaggttgag caagacatgt ttgcacatcc ttatcaatat      780

gaactaaatc actttacccc agcagatgca gtgcttcaaa agccacaacc ccagttatac      840

agacctatag aagagacacc atgccatttc atatcctccc tggatgaact cgtggaactc      900

aacgaaaagc tcttgaattg tcaggaattt gcagttgact tggagcacca ctcttacagg      960

agcttcctgg gactgacctg cctgatgcaa atttctactc ggacggaaga cttcatcatt     1020

gacaccctcg agcttcgaag tgacatgtac attctcaatg agagcctcac agacccagcc     1080

atcgttaagg tctttcatgg tgctgattca gacatagaat ggctacagaa agactttggg     1140

ttgtatgtag taaacatgtt tgatactcat caggcagcac gccttcttaa cctgggcagg     1200

cactcactcg atcatctcct gaaactctac tgcaacgtgg actcaaacaa gcaatatcag     1260

ctggctgatt ggagaatacg ccctctgccc gaggagatgc tcagctacgc ccgggatgac     1320

acccattacc tgctatatat ctatgacaaa atgaggctgg agatgtggga gcgcggcaac     1380

gggcagccgg tgcagctgca ggtggtgtgg caacggagca gggacatctg cctcaagaaa     1440

ttcatcaaac ctatcttcac ggatgagtcc taccttgaac tctataggaa gcagaagaag     1500

caccttaaca cacagcagtt gacagccttt cagctgctgt ttgcctggag ggataaaaca     1560

gctcgcaggg aagatgaaag ttacggatat gtactgccaa accacatgat gctgaaaata     1620

gctgaagaac tgcctaagga acctcagggc atcatagctt gctgcaaccc agtaccgccc     1680

cttgtgcggc agcagatcaa cgaaatgcac cttttaatcc agcaggcccg agagatgccc     1740

ctgctcaagt ctgaagttgc agccggagtg aagaagagcg gaccgctgcc cagtgctgag     1800

agattggaga atgttctctt tggacctcac gactgctccc atgcccctcc ggatggctat     1860

ccaatcatcc caaccagtgg atctgtgcca gttcagaagc aggcgagcct cttccctgat     1920

gaaaaagaag ataacttgct gggtaccaca tgcctgattg ccacagctgt catcacgtta     1980

tttaatgaac ctagtgctga agacagtaaa aagggtccat tgacagttgc acagaaaaaa     2040

gcccagaaca tcatggagtc ctttgaaaat ccatttagga tgatcagcaa ccgctggaag     2100

ctggcccagg tacaagtaca aaaagactct aaagaagctg tcaagaagaa ggcagctgag     2160

caaacagctg cccgggaaca ggcaaaggag gcgtgcaaag ctgcagcaga acaggccatc     2220

tccgtccgac agcaggtcgt gctagaaaat gctgcaaaga agagagagcg agcaacaagc     2280

gacccaagga ccacagaaca gaaacaagag aagaaacgac tcaaaatttc caagaagcca     2340

aaggacccag agccaccaga aaaagagttt acgccttacg actacagcca gtcagacttc     2400

aaggcttttg ctggaaacag caaatccaaa gtttcttctc agtttgatcc aaataaacag     2460

accccgtctg gcaagaaatg cattgcagcc aaaaaaatta aacagtcggt gggaaacaaa     2520

agcatgtcct ttccaactgg aaagtcagac agaggcttca ggtacaactg gccacagaga     2580

tag                                                                   2583


<210>  1048
<211>  882
<212>  DNA
<213>  Homo sapiens

<400>  1048
atggcgatgg agatgaggct tccagtggct cgcaagcctc ttagcgagag actgggccgc       60

gacactaaga aacatctagt ggtgccgggg gatacaatca ctacggacac aggattcatg      120

cggggccatg gaacgtatat gggagaagag aagctcattg catctgttgc tggctctgtg      180

gagagagtaa acaagttgat ctgtgtgaaa gctttgaaaa ccagatacat tggtgaagta      240

ggagacatcg tagtgggacg aatcacagag gttcaacaga agaggtggaa ggtggagacc      300

aactccaggc tggattcggt cttgctgctc tcgtccatga accttcctgg aggagagctg      360

aggagaagat ctgcagaaga tgagcttgca atgagaggtt tcttacagga aggggacctt      420

atcagtgctg aggtccaggc agtgttctct gacggagctg tctctttgca cacgaggagc      480

ctgaaatatg gaaaactagg tcagggggtt ttggtccagg tttccccctc cctggtgaaa      540

cggcagaaga cccactttca tgatttgcca tgtggtgcct cagtgattct cggtaacaac      600

ggcttcatct ggatttaccc aacacctgag cacaaagaag aggaagcagg gggcttcatt      660

gcaaacctgg agcctgtctc tcttgctgat cgagaggtga tatcccggct tcggaactgc      720

atcatctcgc tggtaactca gaggatgatg ctgtatgata ccagcatcct gtactgctat      780

gaagcatccc ttccacatca gatcaaagac atcttaaagc cagaaataat ggaggagatt      840

gtgatggaaa cacgccagag gcttttggaa caggagggat aa                         882


<210>  1049
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  1049
atgaaggaaa cgccactctc aaactgcgaa cgccgcttcc tactccgtgc catcgaagag       60

aagaagcggc tggatggcag acaaacctat gattatagga acatcaggat ctcatttgga      120

acagattacg gatgctgcat tgtggaactt ggaaaaacaa gagttcttgg acaggtttcc      180

tgtgaacttg tgtctccaaa actcaatcgg gcaacagaag gtattctttt ttttaacctt      240

gaactctctc agatggccgc tccagctttc gaacctggca ggcagtcaga tctcttggtg      300

aagttgaatc gactcatgga aagatgtcta agaaattcga agtgtataga cactgagtct      360

ctctgtgttg ttgctggtga aaaggtttgg caaatacgtg tagacctaca tttattaaat      420

catgatggaa atattattga tgctgccagc attgctgcaa tcgtggcctt atgtcatttc      480

cgaagacctg atgtctctgt ccaaggagat gaagtaacac tgtatacacc tgaagagcgt      540

gatcctgtac cattaagtat ccaccacatg cccatttgtg tcagttttgc ctttttccag      600

caaggaacat atttattggt ggatcccaat gaacgagaag aacgtgtgat ggatggcttg      660

ctggtgattg ccatgaacaa acatcgagag atttgtacta tccagtccag tggtgggata      720

atgctactaa aagatcaagt tctgagatgc agtaaaatcg ctggtgtgaa agtagcagaa      780

attacagagc taatattgaa agctttggag aatgaccaaa aagtaaggaa agaaggtgga      840

aagtttggtt ttgcagagtc tatagcaaat caaaggatca cagcatttaa aatggaaaag      900

gcccctattg atacctcgga tgtagaagaa aaagcagaag aaatcattgc tgaagcagaa      960

cctccttcag aagttgtttc tacacctgtg ctatggactc ctggaactgc ccaaattgga     1020

gagggagtag aaaactcctg gggtgatctt gaagactctg agaaggaaga tgatgaaggc     1080

ggtggtgatc aagctatcat tcttgatggt ataaaaatgg acactggagt agaagtctct     1140

gatattggaa gccaagatgc tcccataata ctctcagata gtgaagaaga agaaatgatc     1200

attttggaac cagacaagaa tccaaagaaa ataagaacac agaccaccag tgcaaaacaa     1260

gaaaaagcac caagtaaaaa gccagtgaaa agaagaaaaa agaagagagc tgccaattaa     1320


<210>  1050
<211>  966
<212>  DNA
<213>  Homo sapiens

<400>  1050
atgaagccag gattcagtcc ccgtgggggt ggctttggcg gccgaggggg ctttggtgac       60

cgtggtggtc gtggaggccg agggggcttt ggcgggggcc gaggtcgagg cggaggcttt      120

agaggtcgtg gacgaggagg aggtggaggc ggcggcggcg gtggaggagg aggaagaggt      180

ggtggaggct tccattctgg tggcaaccgg ggtcgtggtc ggggaggaaa aagaggaaac      240

cagtcgggga agaatgtgat ggtggagccg catcggcatg agggtgtctt catttgtcga      300

ggaaaggaag atgcactggt caccaagaac ctggtccctg gggaatcagt ttatggagag      360

aagagagtct cgatttcgga aggagatgac aaaattgagt accgagcctg gaaccccttc      420

cgctccaagc tagcagcagc aatcctgggt ggtgtggacc agatccacat caaaccgggg      480

gctaaggttc tctacctcgg ggctgcctcg ggcaccacgg tctcccatgt ctctgacatc      540

gttggtccgg atggtctagt ctatgcagtc gagttctccc accgctctgg ccgtgacctc      600

attaacttgg ccaagaagag gaccaacatc attcctgtga tcgaggatgc tcgacaccca      660

cacaaatacc gcatgctcat cgcaatggtg gatgtgatct ttgctgatgt ggcccagcca      720

gaccagaccc ggattgtggc cctgaatgcc cacaccttcc tgcgtaatgg aggacacttt      780

gtgatttcca ttaaggccaa ctgcattgac tccacagcct cagccgaggc cgtgtttgcc      840

tccgaagtga aaaagatgca acaggagaac atgaagccgc aggagcagtt gacccttgag      900

ccatatgaaa gagaccatgc cgtggtcgtg ggagtgtaca ggccaccccc caaggtgaag      960

aactga                                                                 966


<210>  1051
<211>  2532
<212>  DNA
<213>  Homo sapiens

<400>  1051
atggttgcag aagaatcagg tcctggtgca caaaatagtc cataccaact tcgtagaaaa       60

actcttttgc cgaaaagaac agcgtgtccc acaaagaaca gtatggaggg cgcctcaact      120

tcaactacag aaaactttgg tcatcgtgca aaacgtgcaa gagtgtctgg aaaatcacaa      180

gatctatcag cagcacctgc tgaacagtat cttcaggaga aactgccaga tgaagtggtt      240

ctaaaaatct tctcttactt gctggaacag gatctttgta gagcagcttg tgtatgtaaa      300

cgcttcagtg aacttgctaa tgatccaatt ttgtggaaac gattatatat ggaagtattt      360

gaatatactc gccctatgat gcatcctgaa cctggaaaat tctaccagat taatccagaa      420

gagtatgaac atccaaatcc ctggaaagag agtttccagc agttgtataa aggtgcacat      480

gtaaagccag gatttgctga acatttctac agtaaccctg caagatataa aggaagagaa      540

aatatgttgt attatgatac tattgaagat gcccttggtg gggtacaaga ggctcatttt      600

gatggactta tctttgttca ttctggaata tatactgatg aatggatata tattgaatct      660

ccaatcacca tgattggtgc agcacctggg aaagtggcag acaaagttat aattgaaaac      720

actagagatt caaccttcgt ttttatggaa ggctctgaag atgcttatgt tggatatatg      780

acaataaggt ttaaccctga tgacaaatct gcacaacacc acaatgcaca ccactgctta      840

gagattacag taaattgtag ccctattatt gatcactgta tcatccgaag tacatgtaca      900

gttggttctg cagtatgtgt tagtggtcaa ggagcatgtc ccaccatcaa gcactgtaac      960

atcagtgact gtgaaaatgt tggactatat ataacagatc atgcacaggg aatatatgag     1020

gataatgaaa tttccaataa tgcgttagct gggatttggg ttaaaaatca tggaaaccca     1080

attattagac ggaatcatat tcatcatgga cgtgatgttg gtgtgttcac atttgatcat     1140

ggcatgggtt actttgaaag ttgcaatata cacagaaata ggatagcagg ctttgaagta     1200

aaagcctatg ctaaccctac agtggttcga tgtgaaattc accatgggca gactggagga     1260

atatatgtcc atgaaaaagg aagaggacaa ttcatagaga ataaaatcta tgcaaacaac     1320

tttgcaggtg tatggattac ctcaaatagt gacccaacaa taaggggaaa ttctatattt     1380

aatggaaatc aaggaggagt ttacatcttt ggtgatggac gaggccttat tgaaggaaat     1440

gacatttatg gcaatgcatt agcaggaatt caaattagga caaacagttg tccaattgtt     1500

cggcataaca aaattcatga tggccagcat ggtgggattt atgtgcatga aaagggacaa     1560

ggagtaatag aagagaatga agtttatagt aacactctag ctggagtctg ggtgacaact     1620

ggcagcactc cagtactgag aagaaaccgg atacacagtg gcaagcaggt tggtgtttat     1680

ttttatgaca atggacatgg agtgctagaa gacaatgata tctataatca tatgtattca     1740

ggggttcaga taaggactgg aagcaacccc aaaattagac gcaacaaaat ctggggagga     1800

cagaatggtg gaattctagt ttataattct ggtctaggct gtatagaaga caatgaaata     1860

tttgacaatg caatggctgg agtctggatt aagacagata gtaatcctac actaagaaga     1920

aataaaatcc atgatggaag agatggtggc atctgtatat ttaatggggg tcgaggtctc     1980

cttgaagaaa atgatatttt caggaatgct caagcaggtg ttctcatcag cactaatagt     2040

catccaatct taaggaaaaa cagaatattt gatggatttg ccgcaggtat tgaaattaca     2100

aatcacgcaa ctgcaacact agaaggcaat cagattttta acaaccggtt tggaggctta     2160

tttttagcat ctggtgttaa tgtgacaatg aaagataaca aaataatgaa caatcaagat     2220

gccatagaaa aggctgttag tagaggccaa tgtttatata aaatatcaag ttataccagc     2280

tatcccatgc atgatttcta cagatgtcat acttgtaaca ccacagatcg aaatgccata     2340

tgtgtgaact gcattaagaa gtgccatcag ggacatgatg tagagtttat tagacatgat     2400

aggtttttct gtgactgtgg tgctggaaca ctgtctaatc cttgtacatt agctggtgag     2460

cctacacatg atacagatac actatatgac tctgctccac ctatagaatc taatacattg     2520

cagcacaact ga                                                         2532


<210>  1052
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  1052
atgattccag cagtggtctt gctcttactc cttttggttg aacaagcagc ggccctggga       60

gagcctcagc tctgctatat cctggatgcc atcctgtttc tgtatggaat tgtcctcacc      120

ctcctctact gtcgactgaa gatccaagtg cgaaaggcag ctataaccag ctatgagaaa      180

tcagatggtg tttacacggg cctgagcacc aggaaccagg agacttacga gactctgaag      240

catgagaaac caccacagta g                                                261


<210>  1053
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  1053
atgggctgtg tgttctgcaa gaaattggag ccggtggcca cggccaagga ggatgctggc       60

ctggaagggg acttcagaag ctacggggca gcagaccact atgggcctga ccccactaag      120

gcccggcctg catcctcatt tgcccacatc cccaactaca gcaacttctc ctctcaggcc      180

atcaaccctg gcttccttga tagtggcacc atcaggggtg tgtcagggat tggggtgacc      240

ctgttcattg ccctgtatga ctatgaggct cgaactgagg atgacctcac cttcaccaag      300

ggcgagaagt tccacatcct gaacaatact gaaggtgact ggtgggaggc tcggtctctc      360

agctccggaa aaactggctg cattcccagc aactacgtgg cccctgttga ctcaatccaa      420

gctgaagagt ggtactttgg aaagattggg agaaaggatg cagagaggca gctgctttca      480

ccaggcaacc cccagggggc ctttctcatt cgggaaagcg agaccaccaa aggtgcctac      540

tccctgtcca tccgggactg ggatcagacc agaggcgatc atgtgaagca ttacaagatc      600

cgcaaactgg acatgggcgg ctactacatc accacacggg ttcagttcaa ctcggtgcag      660

gagctggtgc agcactacat ggaggtgaat gacgggctgt gcaacctgct catcgcgccc      720

tgcaccatca tgaagccgca gacgctgggc ctggccaagg acgcctggga gatcagccgc      780

agctccatca cgctggagcg ccggctgggc accggctgct tcggggatgt gtggctgggc      840

acgtggaacg gcagcactaa ggtggcggtg aagacgctga agccgggcac catgtccccg      900

aaggccttcc tggaggaggc gcaggtcatg aagctgctgc ggcacgacaa gctggtgcag      960

ctgtacgccg tggtgtcgga ggagcccatc tacatcgtga ccgagttcat gtgtcacggc     1020

agcttgctgg attttctcaa gaacccagag ggccaggatt tgaggctgcc ccaattggtg     1080

gacatggcag cccaggtagc tgagggcatg gcctacatgg aacgcatgaa ctacattcac     1140

cgcgacctga gggcagccaa catcctggtt ggggagcggc tggcgtgcaa gatcgcagac     1200

tttggcttgg cgcgtctcat caaggacgat gagtacaacc cctgccaagg ttccaagttc     1260

cccatcaagt ggacagcccc agaagctgcc ctctttggca gattcaccat caagtcagac     1320

gtgtggtcct ttgggatcct gctcactgag ctcatcacca agggccgaat cccctaccca     1380

ggcatgaata aacgggaagt gttggaacag gtggagcagg gctaccacat gccgtgccct     1440

ccaggctgcc cagcatccct gtacgaggcc atggaacaga cctggcgtct ggacccggag     1500

gagaggccta ccttcgagta cctgcagtcc ttcctggagg actacttcac ctccgctgaa     1560

ccacagtacc agcccgggga tcagacatag                                      1590


<210>  1054
<211>  3810
<212>  DNA
<213>  Homo sapiens

<400>  1054
atggaggcca ccggggtgct gccgttcgtg cgtggcgtgg acctcagcgg caacgacttc       60

aagggcggct acttccctga gaatgtcaag gccatgacca gcctgcggtg gctgaagctg      120

aaccgcactg gcctctgcta cctgcccgag gagctggccg ccctgcagaa gctggaacac      180

ttgtctgtga gccacaacaa cctgaccacg cttcatgggg agctgtccag cctgccatcg      240

ctgcgcgcca tcgtggcccg agccaacagt ctgaagaatt ccggagtccc cgatgacatc      300

ttcaagctag atgatctctc agtcctggac ttgagccaca accagctgac agagtgcccg      360

cgggagctgg agaacgccaa gaacatgctg gtgctgaacc tcagccacaa cagcatcgac      420

accatcccca accagctctt catcaacctc actgacctac tatacctgga cctcagcgag      480

aaccgcctgg agagcctgcc cccgcagatg cgccgcctgg tgcacctgca gacgctcgtg      540

ctcaatggaa accccctgct gcatgcacag ctccggcagc tcccagcgat gacggccctg      600

cagaccctgc acctgcggag cacccagcgc acccagagca acctgcccac cagcctggag      660

ggtctgagca acctcgcaga cgtggatctg tcctgcaatg acctgacacg ggtgcccgag      720

tgtctgtaca ccctccccag cctgcgccgc ctcaacctca gcagcaacca gatcacggag      780

ctgtccctgt gcatagacca gtgggtgcac gtggaaactc tgaacctgtc ccgaaatcag      840

ctcacctcac tgccctcagc catttgcaag ctgagcaagc tgaagaagct gtacctgaat      900

tccaacaagc tggactttga cgggctgccc tcaggcattg gcaagctcac caacctggaa      960

gagttcatgg ctgccaacaa caacctggag ctggtccctg aaagtctctg caggtgccca     1020

aagctgagga aacttgtcct gaacaagaac cacctggtga ccctcccaga agccatccat     1080

ttcctgacgg agatcgaggt cctggatgtg cgggagaacc ccaacctggt catgccgccc     1140

aagcccgcag accgtgccgc tgagtggtac aacatcgact tctcgctgca gaaccagctg     1200

cggctagcgg gtgcctctcc tgctaccgtg gctgcagctg cagctgcagg gagtgggccc     1260

aaggacccta tggctcgcaa gatgcgactg cggaggcgca aggattcagc ccaggatgac     1320

caggccaagc aggtgctgaa gggcatgtca gatgttgccc aggagaagaa caaaaagcag     1380

gaggagagcg cagatgcccg ggcccccagc gggaaggtgc ggcgttggga ccagggcctg     1440

gagaagcccc gccttgacta ctccgagttc ttcacggagg acgtgggcca gctgcccgga     1500

ctgaccatct ggcagataga gaacttcgtg cctgtgctgg tggaggaagc cttccacggc     1560

aagttctacg aggctgactg ctacattgtg ctcaagacct ttctggatga cagcggctcc     1620

ctcaactggg agatctacta ctggattggc ggggaggcca cactcgacaa gaaagcttgc     1680

tctgccatcc acgctgtcaa cttgcgcaac tacctgggtg ctgagtgccg cactgtccgg     1740

gaggagatgg gcgatgagag cgaggagttc ctgcaggtgt ttgacaacga catctcctac     1800

attgagggtg gaacagccag tggcttctac actgtggaag acacacacta tgtcaccagg     1860

atgtatcgtg tgtatgggaa aaagaacatc aagttggagc ctgtgcccct caaggggacc     1920

tctctggacc caaggtttgt tttcctgctg gaccgagggc tagacatcta cgtatggcgg     1980

ggggcccagg ccacactgag cagcaccacc aaggccaggc tctttgcaga gaaaattaac     2040

aagaatgagc ggaaagggaa ggctgagatc acactgctgg tgcagggcca ggagctccca     2100

gagttctggg aggcactggg tggggagccc tctgagatca agaagcacgt gcctgaagac     2160

ttctggccgc cgcagcccaa gctgtacaag gtgggcctgg gcttgggcta cctggagctg     2220

ccacagatca actacaagct ctccgtggaa cataagcagc gtcccaaggt ggagctgatg     2280

ccaagaatgc ggctgctgca gagtctgctg gacacgcgct gcgtgtacat tctggactgt     2340

tggtccgacg tgttcatctg gctcggccgc aagtccccgc gcctggtgcg cgctgccgcc     2400

ctcaagctgg gtcaggagct gtgcgggatg ctgcaccggc cacgccatgc cacggtcagc     2460

cgcagcctcg agggcaccga ggcgcaggtg ttcaaggcca agttcaagaa ttgggacgat     2520

gtgttgacgg tggactacac acgcaatgcg gaggccgtgc tgcagagccc gggtctctcc     2580

gggaaggtga aacgcgacgc cgagaagaaa gaccagatga aggctgacct cactgcgctt     2640

ttcctgccgc ggcagccgcc catgtcgctg gccgaggcgg agcagctgat ggaggagtgg     2700

aacgaagacc tagacggcat ggagggtttc gtgctggagg gcaagaagtt tgcgcggctg     2760

ccggaagagg agtttggcca cttctacacg caggactgct acgtcttcct ctgcaggtac     2820

tgggtgcctg tggagtacga ggaggaggaa aagaaggaag acaaggagga gaaggccgag     2880

ggcaaagaag gcgaggaagc aaccgctgag gcagaggaga agcagccaga ggaggacttc     2940

cagtgcatcg tgtacttctg gcagggccgt gaagcctcca atatgggctg gctcaccttc     3000

accttcagcc tgcaaaagaa gttcgagagc ctcttccctg ggaagctgga ggtggtacgc     3060

atgacgcagc agcaggagaa ccccaagttc ctgtcccatt tcaagaggaa gttcatcatc     3120

caccggggca agaggaaggc ggtccagggc gcccaacagc ccagcctcta ccagatccgc     3180

accaacggca gcgccctctg cacccggtgc atccagatca acaccgactc cagcctcctc     3240

aactccgagt tctgcttcat cctcaaggtt ccctttgaga gtgaggacaa ccagggcatc     3300

gtgtatgcct gggtgggccg ggcatcagac cctgacgaag ccaagttggc agaagacatc     3360

ctgaacacca tgtttgacac ctcctacagc aagcaggtta tcaacgaagg tgaggagcct     3420

gagaacttct tctgggtggg cattggggca cagaagccct atgatgacga tgccgagtac     3480

atgaaacaca cacgtctctt ccggtgctcc aacgagaagg gctactttgc agtgactgag     3540

aaatgctccg acttttgcca agatgacctg gcagatgatg acatcatgtt gctagacaat     3600

ggccaagagg tctacatgtg ggtggggacc cagactagcc aggtggagat caagctgagc     3660

ctgaaggcct gccaggtata tatccagcac atgcggtcca aggaacatga gcggccgcgc     3720

cggctgcgcc tggtccgcaa gggcaatgag cagcacgcct ttacccgctg cttccacgcc     3780

tggagcgcct tctgcaaggc cctggcctaa                                      3810


<210>  1055
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  1055
atgtttttca cttgtggccc aaatgaggcc atggtggtct ccgggttctg ccgaagcccc       60

ccagtcatgg tggctggagg gcgtgtcttt gtcctgccct gcatccaaca gatccagagg      120

atctctctca acacactgac cctcaatgtc aagagtgaaa aggtttacac tcgccatggg      180

gtccccatct cagtcactgg cattgcccag gtaaaaatcc aggggcagaa caaggagatg      240

ttggcggccg cctgtcagat gttcctgggg aagacggagg ctgagattgc ccacattgcc      300

ctggagacgt tagagggcca ccagagggcc atcatggccc acatgactgt ggaggagatc      360

tataaggaca ggcagaaatt ctcagaacag gttttcaaag tggcctcctc agacctggtc      420

aacatgggca tcagtgtggt tagctacact ctgaaggaca ttcacgatga ccaggactat      480

ttgcactctt tggggaaggc tcgaacagct caagtccaaa aagatgcacg gattggagaa      540

gcagaggcca agagagatgc tgggatccgg gaagctaaag ccaagcagga aaaggtgtct      600

gctcagtacc tgagtgagat cgagatggcc aaggcacaga gagattacga actgaagaag      660

gccgcctatg acatcgaggt caacacccgc cgagcacagg ctgacctggc ctatcagctt      720

caggtggcca agactaagca gcagattgag gagcagcggg tgcaggtgca ggtggtggag      780

cgggcccagc aggtggcagt gcaggagcag gagatcgccc ggcgggagaa ggagctggag      840

gcccgggtgc ggaagccagc ggaagcggag cgctacaagc tggagcgcct agccgaggca      900

gagaagtccc aactaattat gcaggcggag gcagaagccg cgtctgtgcg gatgcgtggg      960

gaagctgagg cctttgccat aggggcccga gcccgagccg aggctgagca gatggccaag     1020

aaggcagaag ccttccagct gtaccaagag gctgctcagc tggacatgct gctagagaag     1080

ctgccccagg tggcagagga gatcagtggt cccttgactt cagccaataa gatcacactg     1140

gtgtccagcg gcagtgggac catgggggca gccaaagtga ctggggaagt actggacatt     1200

ctaactcgcc tgccagagag tgtggaaaga ctcacaggcg tgagcatctc ccaggtgaat     1260

cacaagcctt tgagaacagc ctga                                            1284


<210>  1056
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  1056
atggcggcca ccgagggggt cggggaggct gcgcaagggg gcgagcccgg gcagccggcg       60

caacccccgc cccagccgca cccaccgccg ccccagcagc agcacaagga agagatggcg      120

gccgaggctg gggaagccgt ggcgtccccc atggacgacg ggtttgtgag cctggactcg      180

ccctcctatg tcctgtacag ggacagagca gaatgggctg atatagatcc ggtgccgcag      240

aatgatggcc ccaatcccgt ggtccagatc atttatagtg acaaatttag agatgtttat      300

gattacttcc gagctgtcct gcagcgtgat gaaagaagtg aacgagcttt taagctaacc      360

cgggatgcta ttgagttaaa tgcagccaat tatacagtgt ggcatttccg gagagttctt      420

ttgaagtcac ttcagaagga tctacatgag gaaatgaact acatcactgc aataattgag      480

gagcagccca aaaactatca agtttggcat cataggcgag tattagtgga atggctaaga      540

gatccatctc aggagcttga atttattgct gatattctta atcaggatgc aaagaattat      600

catgcctggc agcatcgaca atgggttatt caggaattta aactttggga taatgagctg      660

cagtatgtgg accaacttct gaaagaggat gtgagaaata actctgtctg gaaccaaaga      720

tacttcgtta tttctaacac cactggctac aatgatcgtg ctgtattgga gagagaagtc      780

caatacactc tggaaatgat taaactagta ccacataatg aaagtgcatg gaactatttg      840

aaagggattt tgcaggatcg tggtctttcc aaatatccta atctgttaaa tcaattactt      900

gatttacaac caagtcatag ttccccctac ctaattgcct ttcttgtgga tatctatgaa      960

gacatgctag aaaatcagtg tgacaataag gaagacattc ttaataaagc attagagtta     1020

tgtgaaatcc tagctaaaga aaaggacact ataagaaagg aatattggag atacattgga     1080

agatcccttc aaagcaaaca cagcacagaa aatgactcac caacaaatgt acagcaataa     1140


<210>  1057
<211>  1638
<212>  DNA
<213>  Homo sapiens

<400>  1057
atgggccggc ggggctcagc ccccggaaac ggtcgtacac ttcggggctg cgagcgcgga       60

gggcgacgac gacgaagcgc agacagcgtc atggcagagc aggtggccct gagccggacc      120

caggtgtgcg ggatcctgcg ggaagagctt ttccagggcg atgccttcca tcagtcggat      180

acacacatat tcatcatcat gggtgcatcg ggtgacctgg ccaagaagaa gatctacccc      240

accatctggt ggctgttccg ggatggcctt ctgcccgaaa acaccttcat cgtgggctat      300

gcccgttccc gcctcacagt ggctgacatc cgcaaacaga gtgagccctt cttcaaggcc      360

accccagagg agaagctcaa gctggaggac ttctttgccc gcaactccta tgtggctggc      420

cagtacgatg atgcagcctc ctaccagcgc ctcaacagcc acatgaatgc cctccacctg      480

gggtcacagg ccaaccgcct cttctacctg gccttgcccc cgaccgtcta cgaggccgtc      540

accaagaaca ttcacgagtc ctgcatgagc cagataggct ggaaccgcat catcgtggag      600

aagcccttcg ggagggacct gcagagctct gaccggctgt ccaaccacat ctcctccctg      660

ttccgtgagg accagatcta ccgcatcgac cactacctgg gcaaggagat ggtgcagaac      720

ctcatggtgc tgagatttgc caacaggatc ttcggcccca tctggaaccg ggacaacatc      780

gcctgcgtta tcctcacctt caaggagccc tttggcactg agggtcgcgg gggctatttc      840

gatgaatttg ggatcatccg ggacgtgatg cagaaccacc tactgcagat gctgtgtctg      900

gtggccatgg agaagcccgc ctccaccaac tcagatgacg tccgtgatga gaaggtcaag      960

gtgttgaaat gcatctcaga ggtgcaggcc aacaatgtgg tcctgggcca gtacgtgggg     1020

aaccccgatg gagagggcga ggccaccaaa gggtacctgg acgaccccac ggtgccccgc     1080

gggtccacca ccgccacttt tgcagccgtc gtcctctatg tggagaatga gaggtgggat     1140

ggggtgccct tcatcctgcg ctgcggcaag gccctgaacg agcgcaaggc cgaggtgagg     1200

ctgcagttcc atgatgtggc cggcgacatc ttccaccagc agtgcaagcg caacgagctg     1260

gtgatccgcg tgcagcccaa cgaggccgtg tacaccaaga tgatgaccaa gaagccgggc     1320

atgttcttca accccgagga gtcggagctg gacctgacct acggcaacag atacaagaac     1380

gtgaagctcc ctgacgccta tgagcgcctc atcctggacg tcttctgcgg gagccagatg     1440

cacttcgtgc gcagcgacga gctccgtgag gcctggcgta ttttcacccc actgctgcac     1500

cagattgagc tggagaagcc caagcccatc ccctatattt atggcagccg aggccccacg     1560

gaggcagacg agctgatgaa gagagtgggt ttccagtatg agggcaccta caagtgggtg     1620

aacccccaca agctctga                                                   1638


<210>  1058
<211>  3612
<212>  DNA
<213>  Homo sapiens

<400>  1058
atggcggcgt gtggacgtgt acggaggatg ttccgcttgt cggcggcgct gcatctgctg       60

ctgctattcg cggccggggc cgagaaactc cccggccagg gcgtccacag ccagggccag      120

ggtcccgggg ccaactttgt gtccttcgta gggcaggccg gaggcggcgg cccggcgggt      180

cagcagctgc cccagctgcc tcagtcatcg cagcttcagc agcaacagca gcagcagcaa      240

cagcaacagc agcctcagcc gccgcagccg cctttcccgg cgggtgggcc tccggcccgg      300

cggggaggag cgggggctgg tgggggctgg aagctggcgg aggaagagtc ctgcagggag      360

gacgtgaccc gcgtgtgccc taagcacacc tggagcaaca acctggcggt gctcgagtgc      420

ctgcaggatg tgagggagcc tgaaaatgaa atttcttcag actgcaatca tttgttgtgg      480

aattataagc tgaacctaac tacagatccc aaatttgaat ctgtggccag agaggtttgc      540

aaatctacta taacagagat taaagaatgt gctgatgaac cggttggaaa aggttacatg      600

gtttcctgct tggtggatca ccgaggcaac atcactgagt atcagtgtca ccagtacatt      660

accaagatga cggccatcat ttttagtgat taccgtttaa tctgtggctt catggatgac      720

tgcaaaaatg acatcaacat tctgaaatgt ggcagtattc ggcttggaga aaaggatgca      780

cattcacaag gtgaggtggt atcatgcttg gagaaaggcc tggtgaaaga agcagaagaa      840

agagaaccca agattcaagt ttctgaactc tgcaagaaag ccattctccg ggtggctgag      900

ctgtcatcgg atgactttca cttagaccgg catttatatt ttgcttgccg agatgatcgg      960

gagcgttttt gtgaaaatac acaagctggt gagggcagag tgtataagtg cctctttaac     1020

cataaatttg aagaatccat gagtgaaaag tgtcgagaag cacttacaac ccgccaaaag     1080

ctgattgccc aggattataa agtcagttat tcattggcca aatcctgtaa aagtgacttg     1140

aagaaatacc ggtgcaatgt ggaaaacctt ccgcgatcgc gtgaagccag gctctcctac     1200

ttgttaatgt gcctggagtc agctgtacac agagggcgac aagtcagcag tgagtgccag     1260

ggggagatgc tggattaccg acgcatgttg atggaagact tttctctgag ccctgagatc     1320

atcctaagct gtcgggggga gattgaacac cattgttccg gattacatcg aaaagggcgg     1380

accctacact gtctgatgaa agtagttcga ggggagaagg ggaaccttgg aatgaactgc     1440

cagcaggcgc ttcaaacact gattcaggag actgaccctg gtgcagatta ccgcattgat     1500

cgagctttga atgaagcttg tgaatctgta atccagacag cctgcaaaca tataagatct     1560

ggagacccaa tgatcttgtc gtgcctgatg gaacatttat acacagagaa gatggtagaa     1620

gactgtgaac accgtctctt agagctgcag tatttcatct cccgggattg gaagctggac     1680

cctgtcctgt accgcaagtg ccagggagac gcttctcgtc tttgccacac ccacggttgg     1740

aatgagacca gtgaatttat gcctcaggga gctgtgttct cttgtttata cagacacgcc     1800

taccgcactg aggaacaggg aaggaggctc tcacgggagt gccgagctga agtccaaagg     1860

atcctacacc agcgtgccat ggatgtcaag ctggatcctg ccctccagga taagtgcctg     1920

attgatctgg gaaaatggtg cagtgagaaa acagagactg gacaggagct ggagtgcctt     1980

caggaccatc tggatgactt ggtggtggag tgtagagata tagttggcaa cctcactgag     2040

ttagaatcag aggatattca aatagaagcc ttgctgatga gagcctgtga gcccataatt     2100

cagaacttct gccacgatgt ggcagataac cagatagact ctggggacct gatggagtgt     2160

ctgatacaga acaaacacca gaaggacatg aacgagaagt gtgccatcgg agttacccac     2220

ttccagctgg tgcagatgaa ggattttcgg ttttcttaca agtttaaaat ggcctgcaag     2280

gaggacgtgt tgaagctttg cccaaacata aaaaagaagg tggacgtggt gatctgcctg     2340

agcacgaccg tgcgcaatga cactctgcag gaagccaagg agcacagggt gtccctgaag     2400

tgccgcaggc agctccgtgt ggaggagctg gagatgacgg aggacatccg cttggagcca     2460

gatctatacg aagcctgcaa gagtgacatc aaaaacttct gttccgctgt gcaatatggc     2520

aacgctcaga ttatcgaatg tctgaaagaa aacaagaagc agctaagcac ccgctgccac     2580

caaaaagtat ttaagctgca ggagacagag atgatggacc cagagctaga ctacaccctc     2640

atgagggtct gcaagcagat gataaagagg ttctgtccgg aagcagattc taaaaccatg     2700

ttgcagtgct tgaagcaaaa taaaaacagt gaattgatgg atcccaaatg caaacagatg     2760

ataaccaagc gccagatcac ccagaacaca gattaccgct taaaccccat gttaagaaaa     2820

gcctgtaaag ctgacattcc taaattctgt cacggtatcc tgactaaggc caaggatgat     2880

tcagaattag aaggacaagt catctcttgc ctgaagctga gatatgctga ccagcgcctg     2940

tcttcagact gtgaagacca gatccgaatc attatccagg agtccgccct ggactaccgc     3000

ctggatcctc agctccagct gcactgctca gacgagatct ccagtctatg tgctgaagaa     3060

gcagcagccc aagagcagac aggtcaggtg gaggagtgcc tcaaggtcaa cctgctcaag     3120

atcaaaacag aattgtgtaa aaaggaagtg ctaaacatgc tgaaggaaag caaagcagac     3180

atctttgttg acccggtact tcatactgct tgtgccctgg acattaaaca ccactgcgca     3240

gccatcaccc ctggccgcgg gcgtcaaatg tcctgtctca tggaagcact ggaggataag     3300

cgggtgaggt tacagcccga gtgcaaaaag cgcctcaatg accggattga gatgtggagt     3360

tacgcagcaa aggtggcccc agcagatggc ttctctgatc ttgccatgca agtaatgacg     3420

tctccatcta agaactacat tctctctgtg atcagtggga gcatctgtat attgttcctg     3480

attggcctga tgtgtggacg gatcaccaag cgagtgacac gagagctcaa ggacaggcta     3540

caatacaggt cagagacaat ggcttataaa ggtttagtgt ggtctcagga tgtgacaggc     3600

agtccagcct ga                                                         3612


<210>  1059
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  1059
atgtctggct cctccagcgt cgccgctatg aagaaagtgg ttcaacagct ccggctggag       60

gccggactca accgcgtaaa agtttcccag gcagctgcag acttgaaaca gttctgtctg      120

cagaatgctc aacatgaccc tctgctgact ggagtatctt caagtacaaa tcccttcaga      180

ccccagaaag tctgttcctt tttgtag                                          207


<210>  1060
<211>  1677
<212>  DNA
<213>  Homo sapiens

<400>  1060
atggccgctc tcacccggga cccccagttc cagaagctgc agcaatggta ccgcgagcac       60

cgctccgagc tgaacctgcg ccgcctcttc gatgccaaca aggaccgctt caaccacttc      120

agcttgaccc tcaacaccaa ccatgggcat atcctggtgg attactccaa gaacctggtg      180

acggaggacg tgatgcggat gctggtggac ttggccaagt ccaggggcgt ggaggccgcc      240

cgggagcgga tgttcaatgg tgagaagatc aactacaccg agggtcgagc cgtgctgcac      300

gtggctctgc ggaaccggtc aaacacaccc atcctggtag acggcaagga tgtgatgcca      360

gaggtcaaca aggttctgga caagatgaag tctttctgcc agcgtgtccg gagcggtgac      420

tggaaggggt acacaggcaa gaccatcacg gacgtcatca acattggcat tggcggctcc      480

gacctgggac ccctcatggt gactgaagcc cttaagccat actcttcagg aggtccccgc      540

gtctggtatg tctccaacat tgatggaact cacattgcca aaaccctggc ccagctgaac      600

cccgagtcct ccctgttcat cattgcctcc aagaccttta ctacccagga gaccatcacg      660

aatgcagaga cggcgaagga gtggtttctc caggcggcca aggatccttc tgcagtggcg      720

aagcactttg ttgccctgtc tactaacaca accaaagtga aggagtttgg aattgaccct      780

caaaacatgt tcgagttctg ggattgggtg ggaggacgct actcgctgtg gtcggccatc      840

ggactctcca ttgccctgca cgtgggtttt gacaacttcg agcagctgct ctcgggggct      900

cactggatgg accagcactt ccgcacgacg cccctggaga agaacgcccc cgtcttgctg      960

gccctgctgg gtatctggta catcaactgc tttgggtgtg agacacacgc catgctgccc     1020

tatgaccagt acctgcaccg ctttgctgcg tacttccagc agggcgacat ggagtccaat     1080

gggaaataca tcaccaaatc tggaacccgt gtggaccacc agacaggccc cattgtgtgg     1140

ggggagccag ggaccaatgg ccagcatgct ttttaccagc tcatccacca aggcaccaag     1200

atgataccct gtgacttcct catcccggtc cagacccagc accccatacg gaagggtctg     1260

catcacaaga tcctcctggc caacttcttg gcccagacag aggccctgat gaggggaaaa     1320

tcgacggagg aggcccgaaa ggagctccag gctgcgggca agagtccaga ggaccttgag     1380

aggctgctgc cacataaggt ctttgaagga aatcgcccaa ccaactctat tgtgttcacc     1440

aagctcacac cattcatgct tggagccttg gtcgccatgt atgagcacaa gatcttcgtt     1500

cagggcatca tctgggacat caacagcttt gaccagtggg gagtggagct gggaaagcag     1560

ctggctaaga aaatagagcc tgagcttgat ggcagtgctc aagtgacctc tcacgacgct     1620

tctaccaatg ggctcatcaa cttcatcaag cagcagcgcg aggccagagt ccaataa        1677


<210>  1061
<211>  1116
<212>  DNA
<213>  Homo sapiens

<400>  1061
atgtcccatg aaaagagttt tttggtgtct ggggacaact atcctccccc caaccctgga       60

tatccggggg ggccccagcc acccatgccc ccctatgctc agcctcccta ccctggggcc      120

ccttacccac agcccccttt ccagccctcc ccctacggtc agccagggta cccccatggc      180

cccagcccct acccccaagg gggctaccca cagggtccct acccccaagg gggctaccca      240

cagggcccct acccacaaga gggctaccca cagggcccct acccccaagg gggctacccc      300

caggggccat atccccagag ccccttcccc cccaacccct atggacagcc acaggtcttc      360

ccaggacaag accctgactc accccagcat ggaaactacc aggaggaggg tcccccatcc      420

tactatgaca accaggactt ccctgccacc aactgggatg acaagagcat ccgacaggcc      480

ttcatccgca aggtgttcct agtgctgacc ttgcagctgt cggtgaccct gtccacggtg      540

tctgtgttca cttttgttgc ggaggtgaag ggctttgtcc gggagaatgt ctggacctac      600

tatgtctcct atgctgtctt cttcatctct ctcatcgtcc tcagctgttg tggggacttc      660

cggcgaaagc acccctggaa ccttgttgca ctgtcggtcc tgaccgccag cctgtcgtac      720

atggtgggga tgatcgccag cttctacaac accgaggcag tcatcatggc cgtgggcatc      780

accacagccg tctgcttcac cgtcgtcatc ttctccatgc agacccgcta cgacttcacc      840

tcatgcatgg gcgtgctcct ggtgagcatg gtggtgctct tcatcttcgc cattctctgc      900

atcttcatcc ggaaccgcat cctggagatc gtgtacgcct cactgggcgc tctgctcttc      960

acctgcttcc tcgcagtgga cacccagctg ctactgggga acaagcagct gtccctgagc     1020

ccagaagagt atgtgtttgc tgcgctgaac ctgtacacag acatcatcaa catcttcctg     1080

tacatcctca ccatcattgg ccgcgccaag gagtag                               1116


<210>  1062
<211>  1581
<212>  DNA
<213>  Homo sapiens

<400>  1062
ctgggggggc gctcaagctg cgaggatccg ggctgcccgc gagacgagga gcgggcgccc       60

aggatggggt gcatgaagtc caagttcctc caggtcggag gcaatacatt ctcaaaaact      120

gaaaccagcg ccagcccaca ctgtcctgtg tacgtgccgg atcccacatc caccatcaag      180

ccggggccta atagccacaa cagcaacaca ccaggaatca gggaggcagg ctctgaggac      240

atcatcgtgg ttgccctgta tgattacgag gccattcacc acgaagacct cagcttccag      300

aagggggacc agatggtggt cctagaggaa tccggggagt ggtggaaggc tcgatccctg      360

gccacccgga aggagggcta catcccaagc aactatgtcg cccgcgttga ctctctggag      420

acagaggagt ggtttttcaa gggcatcagc cggaaggacg cagagcgcca actgctggct      480

cccggcaaca tgctgggctc cttcatgatc cgggatagcg agaccactaa aggaagctac      540

tctttgtccg tgcgagacta cgaccctcgg cagggagata ccgtgaaaca ttacaagatc      600

cggaccctgg acaacggggg cttctacata tccccccgaa gcaccttcag cactctgcag      660

gagctggtgg accactacaa gaaggggaac gacgggctct gccagaaact gtcggtgccc      720

tgcatgtctt ccaagcccca gaagccttgg gagaaagatg cctgggagat ccctcgggaa      780

tccctcaagc tggagaagaa acttggagct gggcagtttg gggaagtctg gatggccacc      840

tacaacaagc acaccaaggt ggcagtgaag acgatgaagc cagggagcat gtcggtggag      900

gccttcctgg cagaggccaa cgtgatgaaa actctgcagc atgacaagct ggtcaaactt      960

catgcggtgg tcaccaagga gcccatctac atcatcacgg agttcatggc caaaggaagc     1020

ttgctggact ttctgaaaag tgatgagggc agcaagcagc cattgccaaa actcattgac     1080

ttctcagccc agattgcaga aggcatggcc ttcatcgagc agaggaacta catccaccga     1140

gacctccgag ctgccaacat cttggtctct gcatccctgg tgtgtaagat tgctgacttt     1200

ggcctggccc gggtcattga ggacaacgag tacacggctc gggaaggggc caagttcccc     1260

atcaagtgga cagctcctga agccatcaac tttggctcct tcaccatcaa gtcagacgtc     1320

tggtcctttg gtatcctgct gatggagatc gtcacctacg gccggatccc ttacccaggg     1380

atgtcaaacc ctgaagtgat ccgagctctg gagcgtggat accggatgcc tcgcccagag     1440

aactgcccag aggagctcta caacatcatg atgcgctgct ggaaaaaccg tccggaggag     1500

cggccgacct tcgaatacat ccagagtgtg ctggatgact tctacacggc cacagagagc     1560

cagtaccaac agcagccatg a                                               1581


<210>  1063
<211>  3069
<212>  DNA
<213>  Homo sapiens

<400>  1063
atgtacttct gttggggcgc cgactccagg gagctgcagc gccggaggac ggcgggcagc       60

cccggggctg agctactgca ggcggccagc ggggagcgcc actctctgct gctgctgacc      120

aaccacaggg tcctctcgtg cggagacaac agcaggggtc agctgggccg caggggcgcg      180

cagcgcgggg agctgccaga accaattcag gcattggaaa ccctaattgt tgatctcgtg      240

agctgcggga aggagcactc cctggctgtg tgccacaaag gaagggtctt cgcatgggga      300

gctggttctg aagggcagct ggggattgga gaattcaagg aaataagttt cacacctaag      360

aaaataatga ctctgaatga tataaaaata atacaagttt cctgtggaca ctaccactcc      420

ctggcattat caaaagatag ccaagtgttt tcgtggggaa agaacagcca tgggcagctg      480

ggcttgggga aggagttccc ctcccaagcc agcccgcaga gggtgaggtc cctggagggg      540

atcccactgg ctcaggtggc tgccggaggg gctcacagct ttgccctgtc tctctgtggg      600

acttcgtttg gctggggaag taacagtgcc gggcagctgg ccctcagtgg gcgtaatgtc      660

ccagtgcaaa gcaacaagcc tctctcagtc ggtgcactga agaatctagg tgtggtttat      720

atcagctgtg gtgatgcaca cactgcggtg cttacccagg acgggaaagt gttcacattt      780

ggagacaatc gctctggaca gctgggatac agccccactc ctgagaagag aggtccacaa      840

cttgtggaaa gaattgatgg cctagtttcg cagatagatt gtggaagtta tcacaccctg      900

gcatatgtgc acaccactgg tcaggtggta tcttttggtc atggaccaag tgacacaagc      960

aagccaactc atccggaggc cctgacagag aactttgaca ttagctgcct gatttctgct     1020

gaagacttcg tggatgttca agtcaaacac atttttgctg gaacatatgc caactttgtg     1080

acaactcatc aggatactag ttccacacgt gctcccggga aaaccctgcc agaaataagc     1140

cgaattagcc agtccatggc agaaaaatgg atagcagtga aaagaagaag tactgaacat     1200

gaaatggcta aaagtgaaat tagaatgata ttttcatctc ctgcttgtct gactgcaagt     1260

tttttaaaga aaagaggaac tggagaaacg acttccattg atgtggactt agaaatggca     1320

agagatacct tcaagaagtt aacaaaaaag gaatggattt cttccatgat aactacgtgt     1380

ctcgaggatg atctgctcag agctcttcca tgccattctc cacaccaaga agctttatca     1440

gttttcctcc tgctcccaga atgtcctgtg atgcatgatt ctaagaactg gaagaacctg     1500

gtggttccat ttgcaaaggc tgtgtgtgaa atgagtaaac aatctttgca agtcctaaag     1560

aagtgttggg catttttgca agaatcttct ctgaatccgc tgatccagat gcttaaagca     1620

gccatcatct ctcagctgct tcatcagact aaaaccgaac aggatcactg taatgttaaa     1680

gctcttttag gaatgatgaa agaactgcat aaggtaaaca aagctaactg tcgactacca     1740

gaaaatactt tcaacataaa tgaactctcc aacttattaa acttttatat agatagagga     1800

agacagctct ttcgggataa ccacctgata cctgcagaaa cccccagtcc tgttattttc     1860

agtgattttc catttatctt taattcgcta tccaaaatta aattattgca agctgattca     1920

catataaaga tgcagatgtc agaaaagaaa gcatacatgc ttatgcatga aacaattctg     1980

caaaaaaagg atgaatttcc tccatcaccc agatttatac ttagagtcag acgaagtcgc     2040

ctggttaaag atgctctgcg tcaattaagt caagctgaag ctactgactt ctgcaaagta     2100

ttagtggttg aatttattaa tgaaatttgt cctgagtctg gaggggttag ttcagagttc     2160

ttccactgta tgtttgaaga gatgaccaag ccagaatatg gaatgttcat gtatcctgaa     2220

atgggttcct gcatgtggtt tcctgccaag cctaaacctg agaagaaaag atatttcctc     2280

tttggaatgc tgtgtggact ctccttattc aatttaaatg ttgctaacct tcctttccca     2340

ctggctctgt ataaaaaact tctggaccaa aagccatcat tggaagattt aaaagaactc     2400

agtcctcggt tggggaagag tttgcaagaa gttctagatg atgctgctga tgacattgga     2460

gatgcgctct gcatacgctt ttctatacac tgggaccaaa atgatgttga cttaattcca     2520

aatgggatct ccatacctgt ggaccaaacc aacaagagag actatgtttc taagtatatt     2580

gattacattt tcaacgtctc tgtaaaagca gtttatgagg aatttcagag aggattttat     2640

agagtctgtg agaaggagat acttagacat ttctaccctg aagaactaat gacagcaatc     2700

attggaaata ctgattatga ctggaaacag tttgaacaga attcaaagta tgagcaagga     2760

taccaaaaat cacatcctac tatacagttg ttttggaagg ctttccacaa actaaccttg     2820

gatgaaaaga aaaaattcct ctttttcctt acaggacgtg ataggctgca tgcaagaggc     2880

atacagaaaa tggaaatagt atttcgctgt cctgaaactt tcagtgaaag agatcaccca     2940

acatcaataa cttgtcataa tattctctcc ctccctaagt attctacaat ggaaagaatg     3000

gaggaagcac ttcaagtagc catcaacaac aacagaggat ttgtctcacc catgctcaca     3060

cagtcataa                                                             3069


<210>  1064
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  1064
atgcgccctg aagacagaat gttccatatc agagctgtga tcttgagagc cctctccttg       60

gctttcctgc tgagtctccg aggagctggg gccatcaagg cggaccatgt gtcaacttat      120

gccgcgtttg tacagacgca tagaccaaca ggggagttta tgtttgaatt tgatgaagat      180

gagatgttct atgtggatct ggacaagaag gagaccgtct ggcatctgga ggagtttggc      240

caagcctttt cctttgaggc tcagggcggg ctggctaaca ttgctatatt gaacaacaac      300

ttgaatacct tgatccagcg ttccaaccac actcaggcca ccaacgatcc ccctgaggtg      360

accgtgtttc ccaaggagcc tgtggagctg ggccagccca acaccctcat ctgccacatt      420

gacaagttct tcccaccagt gctcaacgtc acgtggctgt gcaacgggga gctggtcact      480

gagggtgtcg ctgagagcct cttcctgccc agaacagatt acagcttcca caagttccat      540

tacctgacct ttgtgccctc agcagaggac ttctatgact gcagggtgga gcactggggc      600

ttggaccagc cgctcctcaa gcactgggag gcccaagagc caatccagat gcctgagaca      660

acggagactg tgctctgtgc cctgggcctg gtgctgggcc tagtcggcat catcgtgggc      720

accgtcctca tcataaagtc tctgcgttct ggccatgacc cccgggccca ggggaccctg      780

tga                                                                    783


<210>  1065
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  1065
atgctgccgt gcctcgtagt gctgctggcg gcgctcctca gcctccgtct tggctcagac       60

gctcatggga cagagctgcc cagccctccg tctgtgtggt ttgaagcaga atttttccac      120

cacatcctcc actggacacc catcccaaat cagtctgaaa gtacctgcta tgaagtggcg      180

ctcctgaggt atggaataga gtcctggaac tccatctcca actgtagcca gaccctgtcc      240

tatgacctta ccgcagtgac cttggacctg taccacagca atggctaccg ggccagagtg      300

cgggctgtgg acggcagccg gcactccaac tggaccgtca ccaacacccg cttctctgtg      360

gatgaagtga ctctgacagt tggcagtgtg aacctagaga tccacaatgg cttcatcctc      420

gggaagattc agctacccag gcccaagatg gcccccgcaa atgacacata tgaaagcatc      480

ttcagtcact tccgagagta tgagattgcc attcgcaagg tgccgggaaa cttcacgttc      540

acacacaaga aagtaaaaca tgaaaacttc agcctcctaa cctctggaga agtgggagag      600

ttctgtgtcc aggtgaaacc atctgtcgct tcccgaagta acaaggggat gtggtctaaa      660

gaggagtgca tctccctcac caggcagtat ttcaccgtga ccaacgtcat catcttcttt      720

gcctttgtcc tgctgctctc cggagccctc gcctactgcc tggccctcca gctgtatgtg      780

cggcgccgaa agaagctacc cagtgtcctg ctcttcaaga agcccagccc cttcatcttc      840

atcagccagc gtccctcccc agagacccaa gacaccatcc acccgcttga tgaggaggcc      900

tttttgaagg tgtccccaga gctgaagaac ttggacctgc acggcagcac agacagtggc      960

tttggcagca ccaagccatc cctgcagact gaagagcccc agttcctcct ccctgaccct     1020

cacccccagg ctgacagaac gctgggaaac agggagcccc ctgtgctggg ggacagctgc     1080

agtagtggca gcagcaatag cacagacagc gggatctgcc tgcaggagcc cagcctgagc     1140

cccagcacag ggcccacctg ggagcaacag gtggggagca acagcagggg ccaggatgac     1200

agtggcattg acttagttca aaactctgag ggccgggctg gggacacaca gggtggctcg     1260

gccttgggcc accacagtcc cccggagcct gaggtgcctg gggaagaaga cccagctgct     1320

gtggcattcc agggttacct gaggcagacc agatgtgctg aagagaaggc aaccaagaca     1380

ggctgcctgg aggaagaatc gcccttgaca gatggccttg gccccaaatt cgggagatgc     1440

ctggttgatg aggcaggctt gcatccacca gccctggcca agggctattt gaaacaggat     1500

cctctagaaa tgactctggc ttcctcaggg gccccaacgg gacagtggaa ccagcccact     1560

gaggaatggt cactcctggc cttgagcagc tgcagtgacc tgggaatatc tgactggagc     1620

tttgcccatg accttgcccc tctaggctgt gtggcagccc caggtggtct cctgggcagc     1680

tttaactcag acctggtcac cctgcccctc atctctagcc tgcagtcaag tgagtga        1737


<210>  1066
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  1066
atggtgcgga agcttaagtt ccacgagcag aagctgctga agcaggtgga cttcctgaac       60

tgggaggtca ccgaccacaa cctgcacgag ctgcgcgtgc tgcggcgtta ccggctgcag      120

cggcgggagg actacacgcg ctacaaccag ctgagccgtg ccgtgcgtga gctggcgcgg      180

cgcctgcgcg acctgcccga acgcgaccag ttccgcgtgc gcgcttcggc cgcgctgctg      240

gacaagctgt atgctctcgg cttggtgccc acgcgcggtt cgctggagct ctgcgacttc      300

gtcacggcct cgtccttctg ccgccgccgc ctccccaccg tgctcctcaa gctgcgcatg      360

gcgcagcacc ttcaggctgc cgtggccttt gtggagcaag ggcacgtacg cgtgggccct      420

gacgtggtta ccgaccccgc cttccttgtc acgcgcagca tggaggactt tgtcacttgg      480

gtggactcgt ccaagatcaa gcggcacgtg ctagagtaca atgaggagcg cgatgacttc      540

gatctggaag cctag                                                       555


<210>  1067
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  1067
atgcccatca ctcggatgcg catgagaccc tggctagaga tgcagattaa ttccaaccaa       60

atcccggggc tcatctggat taataaagag gagatgatct tccagatccc atggaagcat      120

gctgccaagc atggctggga catcaacaag gatgcctgtt tgttccggag ctgggccatt      180

cacacaggcc gatacaaagc aggggaaaag gagccagatc ccaagacgtg gaaggccaac      240

tttcgctgtg ccatgaactc cctgccagat atcgaggagg tgaaagacca gagcaggaac      300

aagggcagct cagctgtgcg agtgtaccgg atgcttccac ctctcaccaa gaaccagaga      360

aaagaaagaa agtcgaagtc cagccgagat gctaagagca aggccaagag gaagtcatgt      420

ggggattcca gccctgatac cttctctgat ggactcagca gctccactct gcctgatgac      480

cacagcagct acacagttcc aggctacatg caggacttgg aggtggagca ggccctgact      540

ccagcactgt cgccatgtgc tgtcagcagc actctccccg actggcacat cccagtggaa      600

gttgtgccgg acagcaccag tgatctgtac aacttccagg tgtcacccat gccctccacc      660

tctgaagcta caacagatga ggatgaggaa gggaaattac ctgaggacat catgaagctc      720

ttggagcagt cggagtggca gccaacaaac gtggatggga aggggtacct actcaatgaa      780

cctggagtcc agcccacctc tgtctatgga gactttagct gtaaggagga gccagaaatt      840

gacagcccag ggggggatat tgggctgagt ctacagcgtg tcttcacaga tctgaagaac      900

atggatgcca cctggctgga cagcctgctg accccagtcc ggttgccctc catccaggcc      960

attccctgtg caccgtag                                                    978


<210>  1068
<211>  1281
<212>  DNA
<213>  Homo sapiens

<400>  1068
atgtgtgacc ggaatggtgg tcggcggctt cgacagtggc tgatcgagca gattgacagt       60

agcatgtatc caggactgat ttgggagaat gaggagaaga gcatgttccg gatcccttgg      120

aaacacgctg gcaagcaaga ttataatcag gaagtggatg cctccatttt taaggcctgg      180

gcagttttta aagggaagtt taaagaaggg gacaaagctg aaccagccac ttggaagacg      240

aggttacgct gtgctttgaa taagagccca gattttgagg aagtgacgga ccggtcccaa      300

ctggacattt ccgagccata caaagtttac cgaattgttc ctgaggaaga gcaaaaatgc      360

aaactaggcg tggcaactgc tggctgcgtg aatgaagtta cagagatgga gtgcggtcgc      420

tctgaaatcg acgagctgat caaggagcct tctgtggacg attacatggg gatgatcaaa      480

aggagccctt ccccgccgga ggcctgtcgg agtcagctcc ttccagactg gtgggcgcag      540

cagcccagca caggcgtgcc gctggtgacg gggtacacca cctacgacgc gcaccattca      600

gcattctccc agatggtgat cagcttctac tatgggggca agctggtggg ccaggccacc      660

accacctgcc ccgagggctg ccgcctgtcc ctgagccagc ctgggctgcc cggcaccaag      720

ctgtatgggc ccgagggcct ggagctggtg cgcttcccgc cggccgacgc catccccagc      780

gagcgacaga ggcaggtgac gcggaagctg ttcgggcacc tggagcgcgg ggtgctgctg      840

cacagcagcc ggcagggcgt gttcgtcaag cggctgtgcc agggccgcgt gttctgcagc      900

ggcaacgccg tggtgtgcaa aggcaggccc aacaagctgg agcgtgatga ggtggtccag      960

gtcttcgaca ccagccagtt cttccgagag ctgcagcagt tctataacag ccagggccgg     1020

cttcctgacg gcagggtggt gctgtgcttt ggggaagagt ttccggatat ggcccccttg     1080

cgctccaaac tcattctcgt gcagattgag cagctgtatg tccggcaact ggcagaagag     1140

gctgggaaga gctgtggagc cggctctgtg atgcaggccc ccgaggagcc gccgccagac     1200

caggtcttcc ggatgtttcc agatatttgt gcctcacacc agagatcatt tttcagagaa     1260

aaccaacaga tcaccgtcta a                                               1281


<210>  1069
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  1069
atgtgcacta aaatggaaca gcccttctac cacgacgact catacacagc tacgggatac       60

ggccgggccc ctggtggcct ctctctacac gactacaaac tcctgaaacc gagcctggcg      120

gtcaacctgg ccgaccccta ccggagtctc aaagcgcctg gggctcgcgg acccggccca      180

gagggcggcg gtggcggcag ctacttttct ggtcagggct cggacaccgg cgcgtctctc      240

aagctcgcct cttcggagct ggaacgcctg attgtcccca acagcaacgg cgtgatcacg      300

acgacgccta cacccccggg acagtacttt tacccccgcg ggggtggcag cggtggaggt      360

gcagggggcg cagggggcgg cgtcaccgag gagcaggagg gcttcgccga cggctttgtc      420

aaagccctgg acgatctgca caagatgaac cacgtgacac cccccaacgt gtccctgggc      480

gctaccgggg ggcccccggc tgggcccggg ggcgtctacg ccggcccgga gccacctccc      540

gtttacacca acctcagcag ctactcccca gcctctgcgt cctcgggagg cgccggggct      600

gccgtcggga ccgggagctc gtacccgacg accaccatca gctacctccc acacgcgccg      660

cccttcgccg gtggccaccc ggcgcagctg ggcttgggcc gcggcgcctc caccttcaag      720

gaggaaccgc agaccgtgcc ggaggcgcgc agccgggacg ccacgccgcc ggtgtccccc      780

atcaacatgg aagaccaaga gcgcatcaaa gtggagcgca agcggctgcg gaaccggctg      840

gcggccacca agtgccggaa gcggaagctg gagcgcatcg cgcgcctgga ggacaaggtg      900

aagacgctca aggccgagaa cgcggggctg tcgagtaccg ccggcctcct ccgggagcag      960

gtggcccagc tcaaacagaa ggtcatgacc cacgtcagca acggctgtca gctgctgctt     1020

ggggtcaagg gacacgcctt ctga                                            1044


<210>  1070
<211>  5313
<212>  DNA
<213>  Homo sapiens

<400>  1070
atgtcgggag cctcagtgaa ggtggctgtc cgggtaaggc ccttcaattc tcgagagacc       60

agcaaggaat ccaaatgcat cattcagatg caaggcaact cgaccagtat tattaaccca      120

aagaatccaa aggaagctcc aaagtccttc agcttcgact attcctactg gtctcatacc      180

tcacccgaag atccctgttt tgcatctcaa aaccgtgtgt acaatgacat tggcaaggaa      240

atgctcttac acgcctttga gggatataat gtctgtattt ttgcctatgg gcagactggt      300

gctggaaaat cttatacaat gatgggtaaa caagaagaaa gccaggctgg catcattcca      360

cagttatgtg aagaactttt tgagaaaatc aatgacaact gtaatgaaga aatgtcttac      420

tctgtagagg tgagctacat ggaaatttac tgtgaaagag tacgagattt gctgaatcca      480

aaaaacaagg gtaatttgcg tgtgcgtgaa cacccacttc ttggacccta tgtggaggat      540

ctgtccaagt tggcagttac ttcctacaca gacattgctg acctcatgga tgctgggaac      600

aaagccagga cagtggcagc tacaaacatg aatgaaacaa gtagccgttc ccacgctgtg      660

tttacgattg ttttcaccca gaagaaacac gataatgaga ccaacctttc cactgagaag      720

gtcagtaaaa tcagcttggt ggatctagca ggaagtgaac gagctgattc aactggtgcc      780

aaagggactc gattaaagga aggagcaaat attaataagt ctcttacaac tttgggcaaa      840

gtcatttcag ccttggccga ggtgagtaaa aagaagaaga aaacagattt tattccctac      900

agggattctg tacttacttg gctccttcga gaaaatttag gtggcaattc tcggactgca      960

atggttgctg ctctgagccc cgcggatatc aactacgatg agactttgag cactctgaga     1020

tatgcagatc gtgcaaaaca aattaaatgc aatgctgtta tcaatgagga ccccaatgcc     1080

aaactggttc gtgaattaaa ggaggaggtg acacggctga aggaccttct tcgtgctcag     1140

ggcctgggag atattattga tacatccatg gggtccctca cttcatcccc atcttcctgc     1200

tcactcagta gtcaggtggg cttgacgtct gtgaccagta ttcaagagag gatcatgtct     1260

acacctggag gagaggaagc tattgaacgt ttaaaggaat cagagaagat cattgctgag     1320

ttgaatgaaa cttgggaaga gaagcttcgt aaaacagagg ccatcagaat ggagagagag     1380

gctttgttgg ctgagatggg agttgccatt cgggaagatg gaggaaccct aggggttttc     1440

tcacctaaaa agaccccaca tcttgttaac ctcaatgaag acccactaat gtctgagtgc     1500

ctactttatt acatcaaaga tggaattaca agggttggcc aagcagatgc tgagcggcgc     1560

caggacatag tgctgagcgg ggctcacatt aaagaagagc attgtatctt ccggagtgag     1620

agaagcaaca gcggggaagt tatcgtgacc ttagagccct gtgagcgctc agaaacctac     1680

gtaaatggca agagggtgtc ccagcctgtt cagctgcgct caggaaaccg tatcatcatg     1740

ggtaaaaacc atgttttccg ctttaaccac ccggaacaag cacgagctga gcgagagaag     1800

actccttctg ctgagacccc ctctgagcct gtggactgga catttgccca gagggagctt     1860

ctggaaaaac aaggaattga tatgaaacaa gagatggaga aaaggctaca ggaaatggag     1920

atcttataca aaaaggagaa ggaagaagca gatcttcttt tggagcagca gagactggac     1980

tatgagagta aattgcaggc cttgcagaag caggttgaaa cccgatctct ggctgcagaa     2040

acaactgaag aggaggaaga agaggaagaa gttccttgga cacagcatga atttgagttg     2100

gcccaatggg ccttccggaa atggaagtct catcagttta cttcattacg ggacttactc     2160

tggggcaatg ccgtgtacct aaaggaggcc aatgccatca gtgtggaact gaaaaagaag     2220

gtgcagtttc agtttgttct gctgactgac acactgtact cccctttgcc tcctgaatta     2280

cttcccactg agatggaaaa aactcatgag gacaggcctt tccctcgcac agtggtagca     2340

gtagaagtcc aggatttgaa gaatggagca acacactatt ggtctttgga gaaactcaag     2400

cagaggctgg atttgatgcg agagatgtat gatagggcag gggagatggc ctccagtgcc     2460

caagacgaaa gcgaaaccac tgtgactggc agcgatccct tctatgatcg gttccactgg     2520

ttcaaacttg tggggagctc ccccattttc cacggctgtg tgaacgagcg ccttgccgac     2580

cgcacaccct cccccacttt ttccacggcc gattccgaca tcactgagct ggctgacgag     2640

cagcaagatg agatggagga ttttgatgat gaggcattcg tggatgacgc cggctctgac     2700

gcagggacgg aggagggatc agatctcttc agtgacgggc atgacccgtt ttacgaccga     2760

tccccttggt tcattttagt gggaagggca tttgtttacc tgagcaatct gctgtatccc     2820

gtgcccctga tccacagggt ggccatcgtc agtgagaaag gtgaagtgcg gggatttctg     2880

cgtgtggctg tacaggccat cgcagcggat gaagaagctc ctgattatgg ctctggaatt     2940

cgacagtcag gaacagctaa aatatctttt gataatgaat actttaatca gagtgacttt     3000

tcgtctgttg caatgactcg ttctggtctg tccttggagg agttgaggat tgtggaagga     3060

cagggtcaga gttctgaggt catcactcct ccagaagaaa tcagtcgaat taatgacttg     3120

gatttgaagt caagcacttt gctggatggt aagatggtaa tggaagggtt ttctgaagag     3180

attggcaacc acctgaaact gggcagtgcc ttcactttcc gagtaacagt gttgcaggcc     3240

agtggaatcc tcccagagta tgcagatatc ttctgtcagt tcaacttttt gcatcgccat     3300

gatgaagcat tctccacgga gcccctcaaa aacaatggca gaggaagtcc cctggccttt     3360

tatcatgtgc agaatattgc agtggagatc actgaatcat ttgtggatta catcaaaacc     3420

aagcctattg tatttgaagt ctttgggcat tatcagcagc acccacttca tctgcaagga     3480

caggagctta acagtccgcc tcagccgtgc cgccgattct tccctccacc catgccactg     3540

tccaagccag ttccagccac caagttaaac acgatgagca aaaccagcct tggccagagc     3600

atgagcaagt atgacctcct ggtttggttt gagatcagtg aactggagcc tacaggagag     3660

tatatcccag ctgtggttga ccacacagca ggcttgcctt gccaggggac atttttgctt     3720

catcagggca tccagcgaag gatcacagtg accattatcc atgagaaggg gagcgagctc     3780

cattggaaag atgttcgtga actggtggta ggtcgtattc ggaataagcc tgaggtggat     3840

gaagctgcag ttgatgccat cctctcccta aatattattt ctgccaagta cctgaagtct     3900

tcccacaact ctagcaggac cttctaccgc tttgaggctg tgtgggatag ctctctgcat     3960

aactcccttc ttctgaaccg agtgacaccc tatggagaaa agatctacat gaccttgtcg     4020

gcctacctag agctggatca ttgcatccag ccggctgtca tcaccaagga tgtgtgcatg     4080

gtcttctact cccgagatgc caagatctca ccaccacgct ctctgcgtag cctctttggc     4140

agcggctact caaagtcacc agattcgaat cgagtcactg gcatttacga actcagctta     4200

tgcaaaatgt cagacacagg tagtccaggt atgcagagaa ggagaagaaa aatcttagat     4260

acgtcagtgg catatgtgcg gggagaagag aacttagcag gctggcggcc ccgtggagac     4320

agcctcatcc ttgagcacca gtgggagctg gagaagctgg agctcctaca tgaggtggaa     4380

aaaacccgcc actttttgct gctgcgtgag agacttggtg acagcatccc caaatccctg     4440

agcgactcgt tatcccccag cctcagcagt gggaccctca gcacctccac cagtatctcc     4500

tctcagatct caaccactac ctttgaaagc gccatcacac ctagcgagag cagtggctat     4560

gattcaggag acatcgaaag cctggtggac cgagagaaag agctggctac caagtgcctg     4620

caacttctca cccacacttt caacagagaa ttcagccagg tgcacggcag cgtcagtgac     4680

tgtaagttgt ctgatatctc tccaattgga cgggatccct ctgagtccag tttcagcagt     4740

gccaccctca ctccctcctc cacctgtccc tctctggtag actctaggag caactctctg     4800

gatcagaaga ccccagaagc caattcccgg gcctctagtc cctgcccaga atttgaacag     4860

tttcagattg tcccagctgt ggaaacacca tatttggccc gagcaggaaa aaacgaattt     4920

ctcaatcttg ttccagatat tgaagaaatt agaccaagct cagtggtctc taagaaagga     4980

taccttcatt tcaaggagcc tctttacagt aactgggcta aacattttgt tgtcgtccgt     5040

cggccttatg tcttcatcta taacagtgac aaagaccctg tggagcgtgg aatcattaac     5100

ctgtccacag cacaggtgga gtacagtgag gaccagcagg ccatggtgaa gacaccaaac     5160

acctttgctg tctgcacaaa gcaccgtggg gtccttttgc aggccctcaa tgacaaagac     5220

atgaacgact ggttgtatgc cttcaaccca cttctagctg gcacaatacg gtcaaagctt     5280

tcccgcagat gcccgagcca gtcgaaatac taa                                  5313


<210>  1071
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  1071
atgttcttgc tgcctcttcc ggctgcgggg cgagtagtcg tccgacgtct ggccgtgaga       60

cgtttcggga gccggagtct ctccaccgca gacatgacga agggccttgt tttaggaatc      120

tattccaaag aaaaagaaga tgatgtgcca cagttcacaa gtgcaggaga gaattttgat      180

aaattgttag ctggaaagct gagagagact ttgaacatat ctggaccacc tctgaaggca      240

gggaagactc gaacctttta tggtctgcat caggacttcc ccagcgtggt gctagttggc      300

ctcggcaaaa aggcagctgg aatcgacgaa caggaaaact ggcatgaagg caaagaaaac      360

atcagagctg ctgttgcagc ggggtgcagg cagattcaag acctggagct ctcgtctgtg      420

gaggtggatc cctgtggaga cgctcaggct gctgcggagg gagcggtgct tggtctctat      480

gaatacgatg acctaaagca aaaaaagaag atggctgtgt cggcaaagct ctatggaagt      540

ggggatcagg aggcctggca gaaaggagtc ctgtttgctt ctgggcagaa cttggcacgc      600

caattgatgg agacgccagc caatgagatg acgccaacca gatttgctga aattattgag      660

aagaatctca aaagtgctag tagtaaaacc gaggtccata tcagacccaa gtcttggatt      720

gaggaacagg caatgggatc attcctcagt gtggccaaag gatctgacga gcccccagtc      780

ttcttggaaa ttcactacaa aggcagcccc aatgcaaacg aaccacccct ggtgtttgtt      840

gggaaaggaa ttacctttga cagtggtggt atctccatca aggcttctgc aaatatggac      900

ctcatgaggg ctgacatggg aggagctgca actatatgct cagccatcgt gtctgctgca      960

aagcttaatt tgcccattaa tattataggt ctggcccctc tttgtgaaaa tatgcccagc     1020

ggcaaggcca acaagccggg ggatgttgtt agagccaaaa acgggaagac catccaggtt     1080

gataacactg atgctgaggg gaggctcata ctggctgatg cgctctgtta cgcacacacg     1140

tttaacccga aggtcatcct caatgccgcc accttaacag gtgccatgga tgtagctttg     1200

ggatcaggtg ccactggggt ctttaccaat tcatcctggc tctggaacaa actcttcgag     1260

gccagcattg aaacagggga ccgtgtctgg aggatgcctc tcttcgaaca ttatacaaga     1320

caggttgtag attgccagct tgctgatgtt aacaacattg gaaaatacag atctgcagga     1380

gcatgtacag ctgcagcatt cctgaaagaa ttcgtaactc atcctaagtg ggcacattta     1440

gacatagcag gcgtgatgac caacaaagat gaagttccct atctacggaa aggcatgact     1500

gggaggccca caaggactct cattgagttc ttacttcgtt tcagtcaaga caatgcttag     1560


<210>  1072
<211>  999
<212>  DNA
<213>  Homo sapiens

<400>  1072
atggcaactc taaaggatca gctgatttat aatcttctaa aggaagaaca gaccccccag       60

aataagatta cagttgttgg ggttggtgct gttggcatgg cctgtgccat cagtatctta      120

atgaaggact tggcagatga acttgctctt gttgatgtca tcgaagacaa attgaaggga      180

gagatgatgg atctccaaca tggcagcctt ttccttagaa caccaaagat tgtctctggc      240

aaagactata atgtaactgc aaactccaag ctggtcatta tcacggctgg ggcacgtcag      300

caagagggag aaagccgtct taatttggtc cagcgtaacg tgaacatctt taaattcatc      360

attcctaatg ttgtaaaata cagcccgaac tgcaagttgc ttattgtttc aaatccagtg      420

gatatcttga cctacgtggc ttggaagata agtggttttc ccaaaaaccg tgttattgga      480

agcggttgca atctggattc agcccgattc cgttacctaa tgggggaaag gctgggagtt      540

cacccattaa gctgtcatgg gtgggtcctt ggggaacatg gagattccag tgtgcctgta      600

tggagtggaa tgaatgttgc tggtgtctct ctgaagactc tgcacccaga tttagggact      660

gataaagata aggaacagtg gaaagaggtt cacaagcagg tggttgagag tgcttatgag      720

gtgatcaaac tcaaaggcta cacatcctgg gctattggac tctctgtagc agatttggca      780

gagagtataa tgaagaatct taggcgggtg cacccagttt ccaccatgat taagggtctt      840

tacggaataa aggatgatgt cttccttagt gttccttgca ttttgggaca gaatggaatc      900

tcagaccttg tgaaggtgac tctgacttct gaggaagagg cccgtttgaa gaagagtgca      960

gatacacttt gggggatcca aaaggagctg caattttaa                             999


<210>  1073
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  1073
atggtggcac caaagagtca cacagatgac tgggctcctg ggcctttctc cagtaagcca       60

cagaggagtc agctgcaaat attctcttct gttctacaga cctctctcct cttcctgctc      120

atgggactaa gagcctctgg aaaggactca gccccaacag tggtgtcagg gatcctaggg      180

ggttccgtga ctctccccct aaacatctca gtagacacag agattgagaa cgtcatctgg      240

attggtccca aaaatgctct tgctttcgca cgtcccaaag aaaatgtaac cattatggtc      300

aaaagctacc tgggccgact agacatcacc aagtggagtt actccctgtg catcagcaat      360

ctgactctga atgatgcagg atcctacaaa gcccagataa accaaaggaa ttttgaagtc      420

accactgagg aggaattcac cctgttcgtc tatgagcagc tgcaggagcc ccaagtcacc      480

atgaagtctg tgaaggtgtc tgagaacttc tcctgtaaca tcactctaat gtgctccgtg      540

aagggggcag agaaaagtgt tctgtacagc tggaccccaa gggaacccca tgcttctgag      600

tccaatggag gctccattct taccgtctcc cgaacaccat gtgacccaga cctgccatac      660

atctgcacag cccagaaccc cgtcagccag agaagctccc tccctgtcca tgttgggcag      720

ttctgtacag atccaggagc ctccagagga ggaacaacgg gggagactgt ggtaggggtc      780

ctgggagagc cagtcaccct gccacttgca ctcccagcct gccgggacac agagaaggtt      840

gtctggttgt ttaacacatc catcattagc aaagagaggg aagaagcagc aacggcagat      900

ccactcatta aatccaggga tccttacaag aacagggtgt gggtctccag ccaggactgc      960

tccctgaaga tcagccagct gaagatagag gacgccggcc cctaccatgc ctacgtgtgc     1020

tcagaggcct ccagcgtcac cagcatgaca catgtcaccc tgctcatcta ccgcaggctg     1080

aggaagccca aaatcacgtg gagcctcagg cacagtgagg atggcatctg caggatcagc     1140

ctgacctgct ccgtggagga cgggggaaac actgtcatgt acacatggac cccgctgcag     1200

aaggaagctg ttgtgtccca aggggaatca cacctcaatg tctcatggag aagcagtgaa     1260

aatcacccca acctcacatg cacagccagc aaccctgtca gcaggagttc ccaccagttt     1320

ctttctgaga acatctgttc aggacctgag agaaacacaa agctttggat tgggttgttc     1380

ctgatggttt gccttctgtg cgttgggatc ttcagctggt gcatttggaa gcgaaaagga     1440

cggtgttcag tcccagcctt ctgttccagc caagctgagg ccccagcgga tacaccagaa     1500

cccacagctg gccacacgct atactctgtg ctctcccaag gatatgagaa gctggacact     1560

cccctcaggc ctgccaggca acagcctaca cccacctcag acagcagctc tgacagcaac     1620

ctcacaactg aggaggatga ggacaggcct gaggtgcaca agcccatcag tggaagatat     1680

gaggtatttg accaggtcac tcaggagggc gctggacatg acccagcccc tgagggccaa     1740

gcagactatg atcccgtcac tccatatgtc acggaagttg agtctgtggt tggagagaac     1800

accatgtatg cacaagtgtt caacttacag ggaaagaccc cagtttctca gaaggaagag     1860

agctcagcca caatctactg ctccatacgg aaacctcagg tggtgccacc accacaacag     1920

aatgatcttg agattcctga aagtcctacc tatgaaaatt tcacctga                  1968


<210>  1074
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  1074
atggcggccg tggagacgcg ggtgtgcgag acagacggct gcagcagtga ggccaagctc       60

cagtgtccca cttgcatcaa gctgggcatc cagggctcgt acttctgctc gcaggaatgt      120

tttaaaggaa gttgggctac tcacaagtta ctacataaga aagcaaaaga tgaaaaggcg      180

aagcgagaag tgtcttcctg gactgtggaa ggtgatatta atactgaccc atgggcaggt      240

tatcgatata ctggtaaact cagaccacat tatccactga tgccaacaag gccagtgcca      300

agttatattc aaagaccaga ttatgctgat catcccttag gaatgtctga atctgaacag      360

gctcttaaag gtacttctca gattaaatta ctctcatctg aagatataga agggatgcga      420

cttgtatgta ggcttgctag agaagttttg gatgttgctg ccggcatgat taaaccaggt      480

gtaactactg aagaaataga tcacgctgta cacttagcat gtattgcaag aaattgctac      540

ccttctcccc tgaattatta taatttccca aagtcttgtt gtacctcagt gaatgaagtc      600

atttgccatg gaataccaga cagaaggccc ttacaagaag gtgacattgt taatgtggat      660

atcactcttt atcgcaatgg ttatcatggg gacctgaatg agacattttt tgttggagaa      720

gtggatgatg gagcacggaa acttgttcag accacatatg agtgcctgat gcaagccatt      780

gatgcagtga agcctggtgt tcggtacaga gaattgggaa acattatcca gaagcatgcc      840

caagcaaatg ggttttcagt tgttcgaagc tattgtgggc atggaatcca caagcttttt      900

catacagctc ccaatgtacc ccactatgct aaaaataaag cagttggagt gatgaagtcg      960

ggccatgtat ttacaattga gccaatgatt tgtgaaggcg gatggcagga tgaaacctgg     1020

ccagatggtt ggactgcggt gacaagagac ggaaagcggt ctgctcagtt tgagcacacc     1080

ctcctggtca cagacactgg ctgtgaaatc ctaacccggc gacttgacag tgcacggcct     1140

cacttcatgt ctcaatttta a                                               1161


<210>  1075
<211>  2751
<212>  DNA
<213>  Homo sapiens

<400>  1075
atggtgcaga aggagagtca agcgacgttg gaggagcggg agagcgagct cagctccaac       60

cctgccgcct ctgcgggggc atcgctggag ccgccggcag ctccggcacc cggagaagac      120

aaccccgccg gggctggggg agcggcggtg gccggggctg caggaggggc tcggcggttc      180

ctctgcggtg tggtggaagg attttatgga agaccttggg ttatggaaca gagaaaagaa      240

ctctttagaa ggctccagaa atgggaatta aatacatact tgtatgcccc aaaagatgac      300

tacaaacata ggatgttttg gcgagagatg tattcagtgg aggaagctga gcaacttatg      360

actctcatct ctgctgcacg agaatatgag atagagttca tctatgcgat ctcacctgga      420

ttggatatca ctttttctaa ccccaaggaa gtatccacat tgaaacgtaa attggaccag      480

gtttctcagt ttgggtgcag atcatttgct ttgctttttg atgatataga ccataatatg      540

tgtgcagcag acaaagaggt attcagttct tttgctcatg cccaagtctc catcacaaat      600

gaaatctatc agtacctagg agagccagaa actttcctct tctgtcccac agaatactgt      660

ggcactttct gttatccaaa tgtgtctcag tctccatatt taaggactgt gggtgaaaag      720

cttctacctg gaattgaagt gctttggaca ggtcccaaag ttgtttctaa agaaattcca      780

gtagagtcca tcgaagaggt ttctaagatt attaagagag ctccagtaat ctgggataac      840

attcatgcta atgattatga tcagaagaga ctgtttctgg gcccgtacaa aggaagatcc      900

acagaactca tcccacggtt aaaaggagtc ctcactaatc caaattgtga atttgaagcc      960

aactacgttg ctatccacac ccttgccacc tggtacaaat caaacatgaa tggagtgaga     1020

aaagatgtag tgatgactga cagtgaagat agtactgtgt ccatccagat aaaattagaa     1080

aatgaaggca gtgatgaaga tattgaaact gatgtactct atagtccaca gatggctcta     1140

aagctagcat taacagaatg gttgcaagag tttggtgtgc ctcatcaata cagcagtagg     1200

caagttgcac acagtggagc taaagcaagt gtagttgatg ggactccttt agttgcagca     1260

ccctctttaa atgccacaac cgtagtaaca acagtttatc aggagcccat tatgagccag     1320

ggagcagcct tgagtggtga gcctactact ctgaccaagg aagaagaaaa gaaacagcct     1380

gatgaagaac ccatggacat ggtggtggaa aaacaagaag aaacggacca caagaatgac     1440

aatcaaatac tgagtgaaat tgttgaagcg aaaatggcag aggaattgaa accaatggac     1500

actgataaag agagcatagc tgaatcaaaa tccccagaga tgtccatgca agaagattgt     1560

attagtgaca ttgcccccat gcaaactgat gaacagacaa acaaggagca gtttgtgcca     1620

ggtccaaatg aaaagccttt gtacactgcg gaaccagtga ccctggagga tttgcagtta     1680

cttgctgatc tattctacct tccttacgag catggaccca aaggagcaca gatgttacgg     1740

gaatttcaat ggcttcgagc aaatagtagt gttgtcagtg tcaattgcaa aggaaaagac     1800

tctgaaaaaa ttgaagaatg gcggtcacga gcagccaagt ttgaagagat gtgtggacta     1860

gtgatgggaa tgttcactcg gctctccaat tgtgccaaca ggacaattct ttatgacatg     1920

tactcctatg tttgggatat caagagtata atgtctatgg tgaagtcttt tgtacagtgg     1980

ttagggtgtc gtagtcattc ttcagcacaa ttcttaattg gagaccaaga accctgggcc     2040

tttagaggtg gtctagcagg agagttccag cgtttgctgc caattgatgg ggcaaatgat     2100

ctcttttttc agccacctcc actgactcct acctccaaag tttatactat cagaccttat     2160

tttcctaagg atgaggcatc cgtgtacaag atttgcagag aaatgtatga cgatggagtg     2220

ggtttaccct ttcaaagtca gcctgatctt attggagaca agttagtagg agggctgctt     2280

tccctcagcc tggattactg ctttgtccta gaagatgaag atggcatatg tggttatgcc     2340

ttgggcactg tagatgtgac cccctttatt aaaaaatgta aaatttcctg gatccccttc     2400

atgcaggaga agtataccaa gccaaatggt gacaaggaac tctctgaggc tgagaaaata     2460

atgttgagtt tccatgaaga acaggaagta ctgccagaaa ctttccttgc taatttccct     2520

tctctgataa agatggacat tcacaaaaaa gtaactgacc caagtgtggc caaaagcatg     2580

atggcttgcc tcctgtcttc actgaaggct aatggctccc ggggagcttt ctgtgaagtg     2640

agaccagatg ataaaagaat tctggaattt tacagcaagt taggatgttt tgaaattgca     2700

aaaatggaag gatttccaaa ggatgtggtt atacttggtc ggagcctgtg a              2751


<210>  1076
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  1076
atggtctcta gcgaccggcc cgtgtcactg gaggacgagg tctcccatag tatgaaggag       60

atgattggag gctgttgcgt ttgctcagac gagagaggct gggccgagaa cccgctggtt      120

tattgcgacg ggcacggctg cagcgtcgcg gtgcatcaag cttgctatgg cattgttcaa      180

gtacccactg gaccgtggtt ttgcaggaaa tgtgaatctc aggagagagc agccagagtg      240

agatgtgaac tttgtcccca taaggatgga gctttaaaaa gaacagataa tgggggttgg      300

gcccatgtgg tttgtgccct gtatattcca gaggtacaat ttgccaatgt ttccacaatg      360

gaaccaattg ttttacagtc tgttccgcat gatcgttata ataagacttg ctacatttgt      420

gatgaacaag gaagagaaag caaagcagcc actggtgctt gcatgacatg taataaacat      480

ggatgtcgac aggctttcca tgtaacatgc gctcagtttg ccggactgct ttgtgaagaa      540

gaaggtaatg gtgccgataa tgtccaatac tgtggctact gtaaatacca ttttagtaag      600

ctgaaaaaga gcaaacgggg atctaatagg tcatatgatc aaagtttaag tgattcttcc      660

tctcactctc aggataaaca tcatgagaaa gagaaaaaaa aatataaaga gaaggacaaa      720

cacaaacaga aacacaagaa gcagccagaa ccatcacctg cattggttcc atccttgact      780

gttactacag aaaaaactta tacaagcact agcaacaact ctatatctgg atcattgaag      840

cgcttggaag atactactgc acgatttaca aatgcaaatt tccaggaagt ctctgcacac      900

acctctagtg gaaaagatgt ttcagagact agagggtcag agggcaaagg gaagaaatct      960

tcagctcaca gctcaggtca aaggggaaga aagcctggtg gtggaagaaa tccaggaaca     1020

actgtgtcag cagctagccc ttttcctcaa ggcagttttt caggaactcc aggcagtgta     1080

aagtcatctt ctggaagttc agtgcagtct ccccaggatt tcctgagctt tacagactca     1140

gatctgcgta atgacagtta ctctcactcc caacagtcat cagcaaccaa agatgtacat     1200

aaaggagagt ctggaagcca ggaagggggg gtaaatagtt ttagtacctt aattggcctc     1260

ccttcaacct cagctgttac ttcacagcct aaaagctttg aaaattcacc tggagatttg     1320

ggtaattcca gccttcctac agcaggatat aagcgggctc aaacttctgg catagaagaa     1380

gaaactgtaa aggaaaagaa aaggaaagga aataaacaaa gtaagcatgg gcctggcaga     1440

cccaaaggaa acaaaaatca agagaatgtt tctcatctct cagtttcttc tgcttcacca     1500

acatcatctg tagcatcagc tgcaggaagc ataacaagct ctagtctgca gaaatctcct     1560

acattgctca ggaatggaag tttacagagc ctcagtgttg gctcatctcc agttggttca     1620

gaaatttcca tgcagtatcg gcatgatgga gcttgcccaa caactacgtt ctcagagttg     1680

ctgaatgcaa tacacaacga cagaggtgac agttctacac taacaaagca agaacttaaa     1740

ttcataggta tttataacag caatgatgta gcagtatcgt ttccaaatgt agtatctggc     1800

tcgggatcta gtactcctgt ctccagctct cacttacctc agcagtcttc tgggcatttg     1860

caacaagtag gagcgctctc tccctcagct gtgtcatctg cagcccctgc tgttgctaca     1920

actcaggcaa atactctatc tggatcttct ctcagtcagg caccatctca tatgtatggc     1980

aatagatcaa attcatcaat ggcagctctt atagctcagt ctgaaaacaa tcaaacagat     2040

caagatcttg gagacaatag ccgcaaccta gttggcagag gaagctcacc ccgaggaagt     2100

ctctcgccac gatcccctgt aagcagctta cagattcgct atgatcaacc aggcaacagc     2160

agtttggaaa atctgcctcc agtagcagcc agcatagaac agcttttgga gaggcagtgg     2220

agtgaaggac agcaattttt actagaacag ggtactccta gtgacatttt aggaatgctg     2280

aagtcattac accaacttca agttgaaaac cgaagattag aggaacaaat taaaaacttg     2340

actgccaaaa aggaacggct tcagttattg aatgcacagc tttcagtgcc ttttccaaca     2400

ataacagcaa atcctagtcc gtctcatcaa atacacacat tttcagcaca gactgctcct     2460

actactgatt ccttgaacag cagtaagagc cctcatatag gaaacagctt tttacctgat     2520

aattctcttc ctgtattaaa tcaggactta acctccagtg gacaaagtac cagcagctca     2580

tcagctcttt ctaccccacc tcctgctggg cagagtccgg ctcaacaagg ctcaggagtg     2640

agtggagttc agcaggtcaa tggcgtgaca gtgggggcac tagctagtgg aatgcagcct     2700

gtaacttcca ccattcctgc cgtgtctgca gtgggtggaa taattggagc tttgccaggt     2760

aaccaactgg caattaatgg cattgtagga gctttaaatg gggttatgca gactcctgtc     2820

acaatgtccc agaaccctac ccctctcacc cacacaaccg taccacctaa tgcaacacat     2880

ccaatgccag ctacactgac taacagtgcc tcaggactag gattactttc tgaccagcaa     2940

cgacaaatac ttattcatca acagcagttt cagcagttgt taaattctca acagctcaca     3000

ccagtacaca ggcaccccca cttcacacag ctaccaccaa cccatttctc accatccatg     3060

gagataatgc aagtcagaaa gtag                                            3084


<210>  1077
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  1077
atgcgacccg accgcgctga ggctccagga ccgcccgcca tggctgcagg aggtcccggc       60

gcggggtctg cggccccggt ctcctccaca tcctcccttc ccctggctgc tctcaacatg      120

cgagtgcggc gccgcctgtc tctgttcttg aacgtgcgga cacaggtggc ggccgactgg      180

accgcgctgg cggaggagat ggactttgag tacttggaga tccggcaact ggagacacaa      240

gcggacccca ctggcaggct gctggacgcc tggcagggac gccctggcgc ctctgtaggc      300

cgactgctcg agctgcttac caagctgggc cgcgacgacg tgctgctgga gctgggaccc      360

agcattgagg aggattgcca aaagtatatc ttgaagcagc agcaggagga ggctgagaag      420

cctttacagg tggccgctgt agacagcagt gtcccacgga cagcagagct ggcgggcatc      480

accacacttg atgaccccct ggggcatatg cctgagcgtt tcgatgcctt catctgctat      540

tgccccagcg acatccagtt tgtgcaggag atgatccggc aactggaaca gacaaactat      600

cgactgaagt tgtgtgtgtc tgaccgcgat gtcctgcctg gcacctgtgt ctggtctatt      660

gctagtgagc tcatcgaaaa gaggtgccgc cggatggtgg tggttgtctc tgatgattac      720

ctgcagagca aggaatgtga cttccagacc aaatttgcac tcagcctctc tccaggtgcc      780

catcagaagc gactgatccc catcaagtac aaggcaatga agaaagagtt ccccagcatc      840

ctgaggttca tcactgtctg cgactacacc aacccctgca ccaaatcttg gttctggact      900

cgccttgcca aggccttgtc cctgccctga                                       930


<210>  1078
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  1078
atgcagctga gaaaaatgca gaccgtcaaa aaggagcagg cgtctcttga tgccagtagc       60

aatgtggaca agatgatggt ccttaattct gctttaacgg aagtgtcaga agactccaca      120

acaggtgagg agctgcttct cagtgaagga agtgtgggga agaacaaatc ttctgcatgt      180

cggaggaaac gggaattcat tcctgatgaa aagaaagatg ctatgtattg ggaaaaaagg      240

cggaaaaata atgaagctgc caaaagatct cgtgagaagc gtcgactgaa tgacctggtt      300

ttagagaaca aactaattgc actgggagaa gaaaacgcca ctttaaaagc tgagctgctt      360

tcactaaaat taaagtttgg tttaattagc tccacagcat atgctcaaga gattcagaaa      420

ctcagtaatt ctacagctgt gtactttcaa gattaccaga cttccaaatc caatgtgagt      480

tcatttgtgg acgagcacga accctcgatg gtgtcaagta gttgtatttc tgtcattaaa      540

cactctccac aaagctcgct gtccgatgtt tcagaagtgt cctcagtaga acacacgcag      600

gagagctctg tgcagggaag ctgcagaagt cctgaaaaca agttccagat tatcaagcaa      660

gagccgatgg aattagagag ctacacaagg gagccaagag atgaccgagg ctcttacaca      720

gcgtccatct atcaaaacta tatggggaat tctttctctg ggtactcaca ctctccccca      780

ctactgcaag tcaaccgatc ctccagcaac tccccgagaa cgtcggaaac tgatgatggt      840

gtggtaggaa agtcatctga tggagaagac gagcaacagg tccccaaggg ccccatccat      900

tctccagttg aactcaagca tgtgcatgca actgtggtta aagttccaga agtgaattcc      960

tctgccttgc cacacaagct ccggatcaaa gccaaagcca tgcagatcaa agtagaagcc     1020

tttgataatg aatttgaggc cacgcaaaaa ctttcctcac ctattgacat gacatctaaa     1080

agacatttcg aactcgaaaa gcatagtgcc ccaagtatgg tacattcttc tcttactcct     1140

ttctcagtgc aagtgactaa cattcaagat tggtctctca aatcggagca ctggcatcaa     1200

aaagaactga gtggcaaaac tcagaatagt ttcaaaactg gagttgttga aatgaaagac     1260

agtggctaca aagtttctga cccagagaac ttgtatttga agcaggggat agcaaactta     1320

tctgcagagg ttgtctcact caagagactt atagccacac aaccaatctc tgcttcagac     1380

tctgggtaa                                                             1389


<210>  1079
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  1079
atgttccagg cggccgagcg cccccaggag tgggccatgg agggcccccg cgacgggctg       60

aagaaggagc ggctactgga cgaccgccac gacagcggcc tggactccat gaaagacgag      120

gagtacgagc agatggtcaa ggagctgcag gagatccgcc tcgagccgca ggaggtgccg      180

cgcggctcgg agccctggaa gcagcagctc accgaggacg gggactcgtt cctgcacttg      240

gccatcatcc atgaagaaaa ggcactgacc atggaagtga tccgccaggt gaagggagac      300

ctggccttcc tcaacttcca gaacaacctg cagcagactc cactccactt ggctgtgatc      360

accaaccagc cagaaattgc tgaggcactt ctgggagctg gctgtgatcc tgagctccga      420

gactttcgag gaaatacccc cctacacctt gcctgtgagc agggctgcct ggccagcgtg      480

ggagtcctga ctcagtcctg caccaccccg cacctccact ccatcctgaa ggctaccaac      540

tacaatggcc acacgtgtct acacttagcc tctatccatg gctacctggg catcgtggag      600

cttttggtgt ccttgggtgc tgatgtcaat gctcaggagc cctgtaatgg ccggactgcc      660

cttcacctcg cagtggacct gcaaaatcct gacctggtgt cactcctgtt gaagtgtggg      720

gctgatgtca acagagttac ctaccagggc tattctccct accagctcac ctggggccgc      780

ccaagcaccc ggatacagca gcagctgggc cagctgacac tagaaaacct tcagatgctg      840

ccagagagtg aggatgagga gagctatgac acagagtcag agttcacgga gttcacagag      900

gacgagctgc cctatgatga ctgtgtgttt ggaggccagc gtctgacgtt atga            954


<210>  1080
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  1080
atgacgcggc atggcaagaa ctgcaccgca ggggccgtct acacctacca cgagaagaag       60

aaggacacag cggcctcggg ctatgggacc cagaacattc gactgagccg ggatgccgtg      120

aaggacttcg actgctgttg tctctccctg cagccttgcc acgatcctgt tgtcacccca      180

gatggctacc tgtatgagcg tgaggccatc ctggagtaca ttctgcacca gaagaaggag      240

attgcccggc agatgaaggc ctacgagaag cagcggggca cccggcgcga ggagcagaag      300

gagcttcagc gggcggcctc gcaggaccat gtgcggggct tcctggagaa ggagtcggct      360

atcgtgagcc ggcccctcaa ccctttcaca gccaaggccc tctcgggcac cagcccagat      420

gatgtccaac ctgggcccag tgtgggtcct ccaagtaagg acaaggacaa agtgctgccc      480

agcttctgga tcccgtcgct gacgcccgaa gccaaggcca ccaagctgga gaagccgtcc      540

cgcacggtga cctgccccat gtcagggaag cccctgcgca tgtcggacct gacgcccgtg      600

cacttcacac cgctagacag ctccgtggac cgcgtggggc tcatcacccg cagcgagcgc      660

tacgtgtgtg ccgtgacccg cgacagcctg agcaacgcca ccccctgcgc tgtgctgcgg      720

ccctctgggg ctgtggtcac cctcgaatgc gtggagaagc tgattcggaa ggacatggtg      780

gaccctgtga ctggagacaa actcacagac cgcgacatca tcgtgctgca gcggggcggt      840

accggcttcg cgggctccgg agtgaagctg caagcggaga aatcacggcc ggtgatgcag      900

gcctga                                                                 906


<210>  1081
<211>  1923
<212>  DNA
<213>  Homo sapiens

<400>  1081
atgaacaaat tacggcaaag ttttaggaga aagaaggatg tttatgttcc agaggccagt       60

cgtccacatc agtggcagac agatgaagaa ggcgttcgca ccggaaaatg tagcttcccg      120

gttaagtacc ttggccatgt agaagttgat gaatcaagag gaatgcacat ctgtgaagat      180

gctgtaaaaa gattgaaagc tactggaaag aaagcagtta aagcagttct gtgggtctca      240

gcagatggac tcagagttgt ggatgaaaaa actaaggacc tcatagttga ccagacgata      300

gagaaagttt ctttctgtgc cccagacagg aactttgata gagccttttc ttacatatgc      360

cgtgatggca ccactcgtcg ctggatctgt cactgcttca tggctgtcaa ggacacaggt      420

gaaaggttga gccatgcagt aggctgtgct tttgcagcct gtttagagcg caagcagaag      480

cgggagaagg aatgtggagt gactgctact tttgatgcta gtcggaccac ttttacaaga      540

gaaggatcat tccgtgtcac aacagccact gaacaagcag aaagagagga gatcatgaaa      600

caaatgcaag atgccaagaa agctgaaaca gataagatag tcgttggttc atcagttgcc      660

cctggcaaca ctgccccatc cccatcctct cccacctctc ctacttctga tgccacgacc      720

tctctggaga tgaacaatcc tcatgccatc ccacgccggc atgctccaat tgaacagctt      780

gctcgccaag gctctttccg aggttttcct gctcttagcc agaagatgtc accctttaaa      840

cgccaactat ccctacgcat caatgagttg ccttccacta tgcagaggaa gactgatttc      900

cccattaaaa atgcagtgcc agaagtagaa ggggaggcag agagcatcag ctccctgtgc      960

tcacagatca ccaatgcctt cagcacacct gaggacccct tctcatctgc tccgatgacc     1020

aaaccagtga cagtggtggc accacaatct cctaccttcc aagctaatgg cactgactca     1080

gccttccatg tgcttgctaa gccagcccat actgctctag cacccgtagc aatgcctgtg     1140

cgtgaaacca acccttgggc ccatgcccct gatgctgcta acaaggaaat tgcagccaca     1200

tgttcgggga ccgagtgggg tcaatcttct ggtgctgcct ctccaggtct cttccaggcc     1260

ggtcatagac gtactccctc tgaggccgac cgatggttag aagaggtgtc taagagcgtc     1320

cgggctcagc agccccaggc ctcagctgct cctctgcagc cagttctcca gcctcctcca     1380

cccactgcca tctcccagcc agcatcacct ttccaaggga atgcattcct cacctctcag     1440

cctgtgccag tgggtgtggt cccagccctg caaccagcct ttgtccctgc ccagtcctat     1500

cctgtggcca atggaatgcc ctatccagcc cctaatgtgc ctgtggtggg catcactccc     1560

tcccagatgg tggccaacgt atttggcact gcaggccacc ctcaggctgc ccatccccat     1620

cagtcaccca gcctggtcag gcagcagaca ttccctcact acgaggcaag cagtgctacc     1680

accagtccct tctttaagcc tcctgctcag cacctcaacg gttctgcagc tttcaatggt     1740

gtagatgatg gcaggttggc ctcagcagac aggcatacag aggttcctac aggcacctgc     1800

ccagtggatc cttttgaagc ccagtgggct gcattagaaa ataagtccaa gcagcgtact     1860

aatccctccc ctaccaaccc tttctccagt gacttacaga agacgtttga aattgaactt     1920

taa                                                                   1923


<210>  1082
<211>  4311
<212>  DNA
<213>  Homo sapiens

<400>  1082
atgcttcacc tgtccgcagc tccgcccgcc ccacccccgg aagtgacggc gaccgcgcgg       60

ccctgccttt gttccgttgg gcgtcgcggc gacggcggga agatggcggc ggcgggagcc      120

ctggaacgga gcttcgtgga gctaagcgga gctgagcgcg aaaggccgag gcactttcgg      180

gaattcacag tctgcagcat tgggactgca aatgccgtgg ctggcgccgt aaaatacagt      240

gaaagcgcgg gaggctttta ctacgtggag agtggcaagt tgttctccgt aaccagaaac      300

aggttcattc attggaagac ctctggagat acattggagc tgatggagga gtcactggac      360

ataaatctgt tgaataatgc cattcgccta aaattccaaa attgcagtgt tttacctgga      420

ggggtttatg tctctgagac tcagaatcgt gtgataatct tgatgttaac caatcaaaca      480

gtgcacaggt tacttttacc acacccctcc cggatgtata ggagtgagtt ggtagttgac      540

agtcagatgc agtcaatatt cactgacatt ggaaaagttg atttcacaga tccttgcaac      600

tatcagttaa ttccagcagt acctggaata tctcctaatt ccaccgcctc tacagcctgg      660

ctcagcagtg atggggaggc cctgtttgcc ttaccatgtg cttctggggg aatctttgtt      720

cttaagctac ctccttatga catacctggt atggtgtcag tcgtggaact gaaacagagt      780

tcagtaatgc aacgattgct tacaggctgg atgccaacag ctatcagggg tgaccagtcg      840

ccttcagatc gtcccctcag tcttgctgtt cattgtgtgg agcatgatgc cttcatcttt      900

gctttgtgtc aggatcataa actacgaatg tggtcttaca aggagcaaat gtgcctaatg      960

gtagctgaca tgctggagta tgtccctgtg aagaaagacc ttcggcttac tgctggaact     1020

ggacacaaat tacggcttgc ttattccccc accatgggac tctacctggg gatatacatg     1080

catgcaccaa aacgaggaca gttctgcatt ttccagttgg tgagcactga gagtaatcgc     1140

tatagtctcg atcatatttc ttcactgttc acttctcagg agacactgat tgactttgcc     1200

ttaacttcca cggatatctg ggccctgtgg catgatgctg agaaccaaac agtagtgaaa     1260

tacatcaact ttgaacataa tgttgcaggt cagtggaatc cagtttttat gcagcctctg     1320

ccagaggaag agattgtcat cagagatgat caagacccca gagagatgta tctgcaaagt     1380

ctttttacac caggacaatt cacaaatgaa gctttatgta aggctttaca gattttctgc     1440

cgaggaactg agaggaattt ggatctttcc tggagtgaac tgaagaaaga agttacttta     1500

gctgttgaaa atgagcttca aggaagtgta acagagtatg aattctccca ggaggagttt     1560

cgaaatttac aacaagaatt ctggtgcaag ttctatgcct gttgtcttca gtatcaagaa     1620

gccctctctc accctcttgc cctacatttg aatccacaca caaacatggt gtgcctgctg     1680

aaaaaagggt acctgtcttt ccttattccc tcatccttag tggatcattt gtatctcctg     1740

ccttatgaga accttttgac agaagatgag acaaccatat ctgatgatgt ggacatcgct     1800

cgggatgtca tatgtcttat aaaatgcctc cggctgattg aagagtcagt aactgtggat     1860

atgtcagtta taatggaaat gagttgttat aacctacagt ctccggaaaa ggctgcagag     1920

cagattctgg aagatatgat cactattgat gtagaaaatg tgatggagga tatttgtagt     1980

aaactgcaag agattaggaa cccaatccat gcaattggac tacttatacg ggaaatggat     2040

tatgaaacag aagtggaaat ggaaaaggga ttcaatccag ctcagccttt gaatattcga     2100

atgaatctta cccagctcta tggtagtaac acagcagggt atattgtgtg cagaggggtg     2160

cataaaatcg ccagtactcg tttcctgatc tgcagagatc ttttgatctt acagcagctg     2220

ttaatgaggc ttggagatgc tgtgatttgg ggaactggtc agctctttca agctcagcaa     2280

gacctactac atcgaacagc tcccctactc ttatcttatt acctcattaa atggggaagt     2340

gagtgcttgg caactgatgt tccacttgac acactggagt ctaatctcca acacttatca     2400

gtactggaat taacagactc tggtgcttta atggcaaata ggtttgtatc tagtcctcag     2460

actattgtgg agttattctt ccaagaagtt gcaagaaaac acattatatc tcacctcttc     2520

tctcagccaa aggcacctct gagccaaact ggattgaatt ggcctgaaat gattactgca     2580

attaccagtt atttattgca gcttttatgg cctagcaatc ctggttgtct ctttctagaa     2640

tgtttgatgg gaaattgcca atatgtacaa ttgcaggatt atattcaact gctacatccc     2700

tggtgtcaag tcaatgttgg ttcctgtcga tttatgctgg gaaggtgtta cctagttaca     2760

ggagaaggac agaaggctct ggaatgtttt tgtcaggcag catctgaagt aggcaaagag     2820

gaattcttgg atcgcttgat tcgctcagag gatggggaga tcgtgtctac ccccaggctg     2880

cagtattatg acaaggtttt acgactacta gatgtcattg gtttgcctga actggttatt     2940

cagttggcta catcagccat aactgaagca ggtgatgact ggaaaagtca ggctactcta     3000

aggacatgta ttttcaaaca tcatttggat ttgggtcaca atagccaagc atatgaagcc     3060

ttaacccaaa ttcctgattc cagcaggcaa ttagattgtt tacggcagtt ggtggtagtt     3120

ctttgtgaac gctcacagct acaggatctt gtagagtttc cctatgtgaa tctgcataat     3180

gaggttgtgg gaataattga gtcacgtgct agagctgtgg accttatgac tcacaattac     3240

tatgaacttc tgtatgcctt tcacatctat cgccacaatt accgcaaggc tggcacagtg     3300

atgtttgagt atggaatgcg gcttggcaga gaagttcgaa ctctccgggg acttgagaaa     3360

caaggcaact gttatctggc tgctctcaat tgtttacgac ttattcgtcc agaatatgcg     3420

tggattgtgc agccagtgtc tggtgcagtg tatgatcgcc ctggagcatc ccctaagagg     3480

aatcatgatg gagaatgcac agctgccccc acaaatcgac aaattgaaat cctggaactg     3540

gaagatctgg agaaagagtg ttccttggct cgcatccgcc tcactttggc tcagcatgat     3600

ccatcagcgg ttgcagttgc tggaagttca tcagcagagg aaatggtcac tctcttggtt     3660

caggcgggcc tctttgacac tgccatatca ctctgtcaga cttttaagct tcccttaacg     3720

ccagtctttg aagggcttgc cttcaaatgc atcaaattgc aatttggagg agaggcagca     3780

caagcagaag cctgggcctg gctagcagcc aatcagctct catctgtcat cactactaag     3840

gagtctagtg ctacagatga agcatggcga ctattatcca cttacctgga gaggtacaaa     3900

gtccagaata acttgtatca ccactgtgta atcaacaagc tcttgtctca tggagtgcct     3960

ctgcctaatt ggcttataaa cagttacaag aaggttgatg ctgctgaatt gcttcgttta     4020

tacttaaact atgacctttt agaagaagct gtggatttgg tgtcagaata tgtggatgct     4080

gtattgggaa aaggacatca atacttcgga attgagtttc cactgtccgc aacagcccca     4140

atggtgtggc ttccatactc ctctattgat cagcttctcc aagctctggg agagaacagt     4200

gccaacagtc acaacatcgc actgtcccag aaaatacttg acaaattgga ggactaccag     4260

caaaaagttg ataaggcaac acgggattta ttatatcgtc ggaccttgtg a              4311


<210>  1083
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  1083
atggatgccg gtgtgactga aagtggacta aatgtgactc tcaccattcg gcttcttatg       60

cacggaaagg aagtaggaag catcattggg aagaaagggg agtcggttaa gaggatccgc      120

gaggagagtg gcgcgcggat caacatctcg gaggggaatt gtccggagag aatcatcact      180

ctgaccggcc ccaccaatgc catctttaag gctttcgcta tgatcatcga caagctggag      240

gaagatatca acagctccat gaccaacagt accgcggcca gcaggccccc ggtcaccctg      300

aggctggtgg tgccggccac ccagtgcggc tccctgattg ggaaaggcgg gtgtaagatc      360

aaagagatcc gcgagagtac gggggcgcag gtccaggtgg cgggggatat gctgcccaac      420

tccaccgagc gggccatcac catcgctggc gtgccgcagt ctgtcaccga gtgtgtcaag      480

cagatttgcc tggtcatgct ggagacgctc tcccagtctc cgcaagggag agtcatgacc      540

attccgtacc agcccatgcc ggccagctcc ccagtcatct gcgcgggcgg ccaagatcgg      600

tgcagcgacg ctgcgggcta cccccatgcc acccatgacc tggagggacc acctctagat      660

gcctactcga ttcaaggaca acacaccatt tctccgctcg atctggccaa gctgaaccag      720

gtggcaagac aacagtctca ctttgccatg atgcacggcg ggaccggatt cgccggaatt      780

gactccagct ctccagaggt gaaaggctat tgggcaagtt tggatgcatc tactcaaacc      840

acccatgaac tcaccattcc aaataactta attggctgca taatcgggcg ccaaggcgcc      900

aacattaatg agatccgcca gatgtccggg gcccagatca aaattgccaa cccagtggaa      960

ggctcctctg gtaggcaggt tactatcact ggctctgctg ccagtattag tctggcccag     1020

tatctaatca atgccaggct ttcctctgag aagggcatgg ggtgcagcta g              1071


<210>  1084
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  1084
atggcgcaca ttaccattaa ccagtacctg cagcaggtgt acgaagccat cgacagcaga       60

gatggagcat cttgtgcaga gttggtgtct tttaaacatc ctcatgttgc aaacccacga      120

cttcaaatgg cctctccaga ggagaagtgt caacaagtct tggaaccccc ttatgatgaa      180

atgtttgcag ctcatttaag gtgcacttat gcagtgggga atcatgactt catagaggca      240

tacaagtgcc agaccgtgat agtccaatca ttcttgcgag cattccaggc ccacaaagaa      300

gaaaactggg ctctgcctgt catgtatgca gtagcgcttg accttcgagt gtttgccaat      360

aatgcagatc aacagttggt aaagaaagga aaaagcaaag ttggggacat gttggaaaaa      420

gcagcagagt tactgatgag ctgtttccgg gtctgtgcca gcgacacccg tgctggtata      480

gaggactcta agaagtgggg catgctgttt ctggtgaacc agctgtttaa aatctacttc      540

aagatcaaca aactccattt atgtaaaccc ctaattagag caattgacag ctcaaacctg      600

aaagacgatt acagcactgc acagagagta acatacaaat actacgttgg acgcaaggct      660

atgtttgaca gcgattttaa gcaagctgag gagtacctgt catttgcctt tgagcattgt      720

caccgttcta gtcagaagaa caaaaggatg attctgatct atttgcttcc agtaaaaatg      780

ctattgggtc acatgcccac tgtggagctc ctgaaaaagt atcacctgat gcagtttgcg      840

gaagtaacca gagctgtgag cgagggcaac ctgctgctgc tgcacgaggc gctggcgaag      900

cacgaggcct tcttcattcg ctgcggaatc ttcctcatcc tggagaagct gaagatcatc      960

acctacagga acctctttaa gaaagtgtat ttgttactga aaacacacca gctgtctctg     1020

gatgcttttc tggttgcctt gaagttcatg caggtggagg acgtggacat tgacgaagtt     1080

cagtgtattc tggctaactt gatatacatg ggacacgtca aaggctacat atcgcatcag     1140

catcagaagc tggtggtcag caagcagaac ccatttcctc ccctgtccac ggtgtgttga     1200


<210>  1085
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  1085
atgccgggag cgcgcagtgg cggcagcggc ggcgacggca gtaacagcgg cagctacagc       60

ggggacgcga gcggggcggt gacggtgtgg gaggtggtct cactcttggg aaaactgctg      120

ggcaccgtcg tcgcgctgaa ggtggttctg tacctgctcc gagtgtgctt agcgatggcc      180

tggaaatccg gcggcgccag ccactcggag ctaatccaca atctccgcaa aaatggaatc      240

atcaagacag ataaagtatt tgaagtgatg ctggctacag accgctccca ctatgcaaaa      300

tgtaacccat acatggattc tccacaatca ataggtttcc aagcaacaat cagtgctcca      360

cacatgcatg catatgcgct agaacttcta tttgatcagt tgcatgaagg agctaaagct      420

cttgatgtag gatctggaag tggaatcctt actgcatgtt ttgcacgtat ggttggatgt      480

actggaaaag tcataggaat tgatcacatt aaagagctag tagatgactc agtaaataat      540

gtcaggaagg acgatccaac acttctgtct tcagggagag tacagcttgt tgtgggggat      600

ggaagaatgg gatatgctga agaagcccct tatgatgcca ttcatgtggg agctgcagcc      660

cctgttgtac cccaggcgct aatagatcag ttaaagcccg gaggaagatt gatattgcct      720

gttggtcctg caggcggaaa ccaaatgttg gagcagtatg acaagctaca agatggcagc      780

atcaaaatga agcctctgat gggggtgata tacgtgcctt taacagataa agaaaagcag      840

tggtccaggt ggaagtga                                                    858


<210>  1086
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  1086
atggcccaag ctgacatcgc gctgatcgga ttggccgtca tgggccagaa cttaattctg       60

aacatgaatg accacggctt tgtggtctgt gcttttaata ggactgtctc caaagttgat      120

gatttcttgg ccaatgaggc aaagggaacc aaagtggtgg gtgcccagtc cctgaaagag      180

atggtctcca agctgaagaa gccccggcgg atcatcctcc tggtgaaggc tgggcaagct      240

gtggatgatt tcatcgagaa attggtacca ttgttggata ctggtgacat catcattgac      300

ggaggaaatt ctgaatatag ggacaccaca agacggtgcc gagacctcaa ggccaaggga      360

attttatttg tggggagcgg agtcagtggt ggagaggaag gggcccggta tggcccatcg      420

ctcatgccag gagggaacaa agaagcgtgg ccccacatca agaccatctt ccaaggcatt      480

gctgcaaaag tgggaactgg agaaccctgc tgtgactggg tgggagatga gggagcaggc      540

cacttcgtga agatggtgca caacgggata gagtatgggg acatgcagct gatctgtgag      600

gcataccacc tgatgaaaga cgtgctgggc atggcgcagg acgagatggc ccaggccttt      660

gaggattgga ataagacaga gctagactca ttcctgattg aaatcacagc caatattctc      720

aagttccaag acaccgatgg caaacacctg ctgccaaaga tcagggacag cgcggggcag      780

aagggcacag ggaagtggac cgccatctcc gccctggaat acggcgtacc cgtcaccctc      840

attggagaag ctgtctttgc tcggtgctta tcatctctga aggatgagag aattcaagct      900

agcaaaaagc tgaagggtcc ccagaagttc cagtttgatg gtgataagaa atcattcctg      960

gaggacattc ggaaggcact ctacgcttcc aagatcatct cttacgctca aggctttatg     1020

ctgctaaggc aggcagccac cgagtttggc tggactctca attatggtgg catcgccctg     1080

atgtggagag ggggctgcat cattagaagt gtattcctag gaaagataaa ggatgcattt     1140

gatcgaaacc cggaacttca gaacctccta ctggacgact tctttaagtc agctgttgaa     1200

aactgccagg actcctggcg gcgggcagtc agcactgggg tccaggctgg cattcccatg     1260

ccctgtttta ccactgccct ctccttctat gacgggtaca gacatgagat gcttccagcc     1320

agcctcatcc aggctcagcg ggattacttc ggggctcaca cctatgaact cttggccaaa     1380

ccagggcagt ttatccacac caactggaca ggccatggtg gcaccgtgtc atcctcgtca     1440

tacaatgcct ga                                                         1452


<210>  1087
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  1087
atgggtcacc cgccgctgct gccgctgctg ctgctgctcc acacctgcgt cccagcctct       60

tggggcctgc ggtgcatgca gtgtaagacc aacggggatt gccgtgtgga agagtgcgcc      120

ctgggacagg acctctgcag gaccacgatc gtgcgcttgt gggaagaagg agaagagctg      180

gagctggtgg agaaaagctg tacccactca gagaagacca acaggaccct gagctatcgg      240

actggcttga agatcaccag ccttaccgag gttgtgtgtg ggttagactt gtgcaaccag      300

ggcaactctg gccgggctgt cacctattcc cgaagccgtt acctcgaatg catttcctgt      360

ggctcatcag acatgagctg tgagaggggc cggcaccaga gcctgcagtg ccgcagccct      420

gaagaacagt gcctggatgt ggtgacccac tggatccagg aaggtgaaga agggcgtcca      480

aaggatgacc gccacctccg tggctgtggc taccttcccg gctgcccggg ctccaatggt      540

ttccacaaca acgacacctt ccacttcctg aaatgctgca acaccaccaa atgcaacgag      600

ggcccaatcc tggagcttga aaatctgccg cagaatggcc gccagtgtta cagctgcaag      660

gggaacagca cccatggatg ctcctctgaa gagactttcc tcattgactg ccgaggcccc      720

atgaatcaat gtctggtagc caccggcact cacgaaccga aaaaccaaag ctatatggta      780

agaggctgtg caaccgcctc aatgtgccaa catgcccacc tgggtgacgc cttcagcatg      840

aaccacattg atgtctcctg ctgtactaaa agtggctgta accacccaga cctggatgtc      900

cagtaccgca gtggggctgc tcctcagcct ggccctgccc atctcagcct caccatcacc      960

ctgctaatga ctgccagact gtggggaggc actctcctct ggacctaa                  1008


<210>  1088
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  1088
atggacaaac aaaactcaca gatgaatgct tctcacccgg aaacaaactt gccagttggg       60

tatcctcctc agtatccacc gacagcattc caaggacctc caggatatag tggctaccct      120

gggccccagg tcagctaccc acccccacca gccggccatt caggtcctgg cccagctggc      180

tttcctgtcc caaatcagcc agtgtataat cagccagtat ataatcagcc agttggagct      240

gcaggggtac catggatgcc agcgccacag cctccattaa actgtccacc tggattagaa      300

tatttaagtc agatagatca gatactgatt catcagcaaa ttgaacttct ggaagtttta      360

acaggttttg aaactaataa caaatatgaa attaagaaca gctttggaca gagggtttac      420

tttgcagcgg aagatactga ttgctgtacc cgaaattgct gtgggccatc tagacctttt      480

accttgagga ttattgataa tatgggtcaa gaagtcataa ctctggagag accactaaga      540

tgtagcagct gttgttgtcc ctgctgcctt caggagatag aaatccaagc tcctcctggt      600

gtaccaatag gttatgttat tcagacttgg cacccatgtc taccaaagtt tacaattcaa      660

aatgagaaaa gagaggatgt actaaaaata agtggtccat gtgttgtgtg cagctgttgt      720

ggagatgttg attttgagat taaatctctt gatgaacagt gtgtggttgg caaaatttcc      780

aagcactgga ctggaatttt gagagaggca tttacagacg ctgataactt tggaatccag      840

ttccctttag accttgatgt taaaatgaaa gctgtaatga ttggtgcctg tttcctcatt      900

gacttcatgt tttttgaaag cactggcagc caggaacaaa aatcaggagt gtggtag         957


<210>  1089
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  1089
atgaatgcca gaggacttgg atctgagcta aaggacagta ttccagttac tgaactttca       60

gcaagtggac cttttgaaag tcatgatctt cttcggaaag gtttttcttg tgtgaaaaat      120

gaacttttgc ctagtcatcc ccttgaatta tcagaaaaaa atttccagct caaccaagat      180

aaaatgaatt tttccacact gagaaacatt cagggtctat ttgctccgct aaaattacag      240

atggaattca aggcagtgca gcaggttcag cgtcttccat ttctttcaag ctcaaatctt      300

tcactggatg ttttgagggg taatgatgag actattggat ttgaggatat tcttaatgat      360

ccatcacaaa gcgaagtcat gggagagcca cacttgatgg tggaatataa acttggttta      420

ctgtaa                                                                 426


<210>  1090
<211>  2184
<212>  DNA
<213>  Homo sapiens

<400>  1090
atgcagcaga agaccaaatt atttctccaa gctttgaagt atagtattcc tcaccttgga       60

aaatgcatgc agaaacagca tttgaatcac tataacttcg ctgatcattg ttacaataga      120

ataaaattga aaaaatatca cctaaccaag tgtcttcaga ataaacccaa gatatcagag      180

ttagcaagaa acatcccaag tcggagcttc tcatgtaagg atcttcagcc tgttaaacaa      240

gaaaacgaaa aaccccttcc agaaaacatg gatgcatttg aaaaagtgag aacaaaatta      300

gaaacacagc cacaagaaga atatgaaatc atcaatgtgg aagttaaaca tggtggtttt      360

gtttattacc aagaaggttg ttgcttggtt cgttccaaag atgaagaagc agacaatgat      420

aattatgaag ttttattcaa tttggaggaa cttaagttag accagccctt cattgattgt      480

atcagagttg ctccagatga aaaatatgtg gctgccaaga taagaactga agattctgaa      540

gcatctacct gtgtaattat aaagctcagc gatcagcccg taatggaagc ttctttcccg      600

aatgtgtcca gttttgaatg ggtaaaggac gaggaagatg aagatgtttt attctacacc      660

ttccagagga accttcgctg tcatgacgta tatcgagcca cttttggtga taacaaacgt      720

aatgaacgct tttacacaga aaaagaccca agctactttg ttttccttta tcttacaaaa      780

gacagtcgtt tcctcaccat aaatattatg aacaagacta cttctgaagt gtggttgata      840

gatggcctga gcccttggga cccaccagta cttatccaga agcgaataca tggggtcctt      900

tactatgttg aacacagaga tgatgaatta tacattctca ctaatgttgg agaacctaca      960

gaatttaagc taatgagaac agcggctgat acccctgcaa ttatgaattg ggatttattt     1020

tttacaatga agagaaatac aaaagtgata gacttggaca tgtttaagga tcactgtgtt     1080

ctatttctga agcacagcaa tctcctttat gttaatgtga ttggtctggc tgatgattca     1140

gttcggtctc taaagctccc tccttgggcc tgtggattca taatggatac aaattctgac     1200

ccaaagaact gcccctttca actttgctct ccaatacgtc ccccaaaata ttacacatac     1260

aagtttgcag aaggcaaact gtttgaggaa actgggcatg aagacccaat cacaaagact     1320

agtcgcgttt tacgtctaga agccaaaagc aaggatggaa aattagtgcc aatgactgtt     1380

ttccacaaaa ctgactctga ggacttgcag aagaaacctc tcttggtaca tgtatatgga     1440

gcttatggaa tggatttgaa aatgaatttc aggcctgaga ggcgggtcct ggtggatgat     1500

ggatggatat tagcatactg ccatgttcga ggtggtggtg agttaggcct ccagtggcac     1560

gctgatggcc gcctaactaa aaaactcaat ggccttgctg atttagaggc ttgcattaag     1620

acgcttcatg gccaaggctt ttctcagcca agtctaacaa ccctgactgc tttcagtgct     1680

ggaggggtgc ttgcaggagc attgtgtaat tctaatccag agctggtgag agcggtgact     1740

ttggaggcac ctttcttgga tgttctcaac accatgatgg acactacact tcctctgaca     1800

ttagaagaat tagaagaatg ggggaatcct tcatctgatg aaaaacacaa gaactacata     1860

aaacgttact gtccctatca aaatattaaa cctcagcatt atccttcaat tcacataacg     1920

gcatatgaaa acgatgaacg ggtacctctg aaaggaattg taagttatac tgagaaactc     1980

aaggaagcca tcgcggagca tgctaaggac acaggtgaag gctatcagac ccctaatatt     2040

attctagata ttcagcctgg aggcaatcat gtaattgagg attctcacaa aaagattaca     2100

gcccaaatta aattcctgta cgaggaactt ggacttgaca gcaccagtgt tttcgaggat     2160

cttaagaaat acctgaaatt ctga                                            2184


<210>  1091
<211>  2031
<212>  DNA
<213>  Homo sapiens

<400>  1091
atggcgccgt tcctgcgcat cgccttcaac tcctatgagc tgggctccct gcaggccgag       60

gacgaggcga accagccctt ctgtgccgtg aagatgaagg aggcgctcag cacagagcgt      120

gggaaaacac tggtgcagaa gaagccgacc atgtatcctg agtggaagtc gacgttcgat      180

gcccacatct atgaggggcg cgtcatccag attgtgctaa tgcgggcagc agaggagcca      240

gtgtctgagg tgaccgtggg tgtgtcggtg ctggccgagc gctgcaagaa gaacaatggc      300

aaggctgagt tctggctgga cctgcagcct caggccaagg tgttgatgtc tgttcagtat      360

ttcctggagg acgtggattg caaacagtct atgcgcagtg aggacgaggc caagttccca      420

acgatgaacc gccgcggagc catcaaacag gccaaaatcc actacatcaa gaaccatgag      480

tttatcgcca ccttctttgg gcaacccacc ttctgttctg tgtgcaaaga ctttgtctgg      540

ggcctcaaca agcaaggcta caaatgcagg caatgtaacg ctgccatcca caagaaatgc      600

atcgacaaga tcatcggcag atgcactggc accgcggcca acagccggga cactatattc      660

cagaaagaac gcttcaacat cgacatgccg caccgcttca aggttcacaa ctacatgagc      720

cccaccttct gtgaccactg cggcagcctg ctctggggac tggtgaagca gggattaaag      780

tgtgaagact gcggcatgaa tgtgcaccat aaatgccggg agaaggtggc caacctctgc      840

ggcatcaacc agaagctttt ggctgaggcc ttgaaccaag tcacccagag agcctcccgg      900

agatcagact cagcctcctc agagcctgtt gggatatatc agggtttcga gaagaagacc      960

ggagttgctg gggaggacat gcaagacaac agtgggacct acggcaagat ctgggagggc     1020

agcagcaagt gcaacatcaa caacttcatc ttccacaagg tcctgggcaa aggcagcttc     1080

gggaaggtgc tgcttggaga gctgaagggc agaggagagt actttgccat caaggccctc     1140

aagaaggatg tggtcctgat cgacgacgac gtggagtgca ccatggttga gaagcgggtg     1200

ctgacacttg ccgcagagaa tccctttctc acccacctca tctgcacctt ccagaccaag     1260

gaccacctgt tctttgtgat ggagttcctc aacggggggg acctgatgta ccacatccag     1320

gacaaaggcc gctttgaact ctaccgtgcc acgttttatg ccgctgagat aatgtgtgga     1380

ctgcagtttc tacacagcaa gggcatcatt tacagggacc tcaaactgga caatgtgctg     1440

ctggaccggg atggccacat caagattgcc gactttggga tgtgcaaaga gaacatattc     1500

ggggagagcc gggccagcac cttctgcggc acccctgact atatcgcccc tgagatccta     1560

cagggcctga agtacacatt ctctgtggac tggtggtctt tcggggtcct tctgtacgag     1620

atgctcattg gccagtcccc cttccatggt gatgatgagg atgaactctt cgagtccatc     1680

cgtgtggaca cgccacatta tccccgctgg atcaccaagg agtccaagga catcctggag     1740

aagctctttg aaagggaacc aaccaagagg ctgggagtga ccggaaacat caaaatccac     1800

cccttcttca agaccataaa ctggactctg ctggaaaagc ggaggttgga gccacctttc     1860

aggcccaaag tgaagtcacc cagagactac agtaactttg accaggagtt cctgaacgag     1920

aaggcgcgcc tctcctacag cgacaagaac ctcatcgact ccatggacca gtctgcattc     1980

gctggcttct cctttgtgaa ccccaaattc gagcacctcc tggaagattg a              2031


<210>  1092
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  1092
atgtctgatg gagattatga ttacctcatc aagtttttag ctttgggaga ctctggtgta       60

gggaagacca gtgtacttta ccaatataca gatggtaaat ttaactccaa atttatcaca      120

acagtgggca ttgatttcag ggaaaaaaga gtggtgtaca gagccagtgg gccggatgga      180

gccactggca gaggccagag aatccacctg cagttatggg acacagcagg gcaggagagg      240

tttcgtagct taacgacagc gttcttcaga gatgctatgg gttttcttct actttttgat      300

ctgacaaatg agcaaagttt cctcaatgtc agaaactgga taagccagct acagatgcat      360

gcatattgtg aaaacccaga tatagtgctg tgtggaaaca agagtgatct ggaggaccag      420

agagtagtga aagaggagga agccatagca ctcgcagaga aatatggaat cccctacttt      480

gaaactagtg ctgccaatgg gacaaacata agccaagcaa ttgagatgct tctggacctg      540

ataatgaagc gaatggaacg gtgtgtggac aagtcctgga ttcctgaagg agtggtgcga      600

tcaaatggtc atgcctctac ggatcagtta agtgaagaaa aggagaaagg ggcatgtggc      660

tgttga                                                                 666


<210>  1093
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  1093
atgacctcta ggaagaaagt gttgctgaag gttatcatcc tgggagattc tggagtcggg       60

aagacatcac tcatgaacca gtatgtgaat aagaaattca gcaatcagta caaagccaca      120

ataggagctg actttctgac caaggaggtg atggtggatg acaggctagt cacaatgcag      180

atatgggaca cagcaggaca ggaacggttc cagtctctcg gtgtggcctt ctacagaggt      240

gcagactgct gcgttctggt atttgatgtg actgccccca acacattcaa aaccctagat      300

agctggagag atgagtttct catccaggcc agtccccgag atcctgaaaa cttcccattt      360

gttgtgttgg gaaacaagat tgacctcgaa aacagacaag tggccacaaa gcgggcacag      420

gcctggtgct acagcaaaaa caacattccc tactttgaga ccagtgccaa ggaggccatc      480

aacgtggagc aggcgttcca gacgattgca cggaatgcac ttaagcagga aacggaggtg      540

gagctgtaca acgaatttcc tgaacctatc aaactggaca agaatgaccg ggccaaggcc      600

tcggcagaaa gctgcagttg ctga                                             624


<210>  1094
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  1094
atggctgcca acaagagtaa gggccagagc tccttggccc tccacaaggt gatcatggtt       60

ggcagcggag gcgttggcaa gtcagccctg acgcttcagt tcatgtatga cgagtttgta      120

gaagactatg aacctaccaa agctgacagt tatagaaaga aagtggttct tgatggggaa      180

gaagttcaga tagatattct ggacaccgct gggcaagagg actacgcagc cattcgagat      240

aactactttc ggagtgggga agggtttctt cttgtgttct caatcacaga acatgaatcc      300

tttacagcaa ctgccgaatt cagggaacag attctccgtg tgaaggctga agaagataaa      360

attccactgc tcgtcgtggg aaacaagtct gacctagagg agcggaggca ggtgcctgtg      420

gaggaggcca ggagtaaagc cgaagagtgg ggcgtgcagt acgtggagac gtcagcgaag      480

acccgggcca acgtggacaa ggtgttcttt gacctaatga gagaaatcag aacaaagaag      540

atgtcagaaa acaaagacaa gaatggcaag aaaagcagca agaacaagaa aagttttaaa      600

gaaagatgtt gcttactatg a                                                621


<210>  1095
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  1095
atgggcaaag tgtggaaaca gcagatgtac cctcagtacg ccacctacta ttacccccag       60

tatctgcaag ccaagcagtc tctggtccca gcccacccca tggcccctcc cagtcccagc      120

accaccagca gtaataacaa cagtagcagc agtagcaact caggatggga tcagctcagc      180

aaaacgaacc tctatatccg aggactgcct ccccacacca ccgaccagga cctggtgaag      240

ctctgtcaac catatgggaa aatagtctcc acaaaggcaa ttttggataa gacaacgaac      300

aaatgcaaag gttatggttt tgtcgacttt gacagccctg cagcagctca aaaagctgtg      360

tctgccctga aggccagtgg ggttcaagct caaatggcaa agcaacagga acaagatcct      420

accaacctct acatttctaa tttgccactc tccatggatg agcaagaact agaaaatatg      480

ctcaaaccat ttggacaagt tatttctaca aggatactac gtgattccag tggtacaagt      540

cgtggtgttg gctttgctag gatggaatca acagaaaaat gtgaagctgt tattggtcat      600

tttaatggaa aatttattaa gacaccacca ggagtttctg cccccacaga acctttattg      660

tgtaagtttg ctgatggagg acagaaaaag agacagaacc caaacaaata catccctaat      720

ggaagaccat ggcatagaga aggagaggtg agacttgctg gaatgacact tacttacgac      780

ccaactacag ctgctataca gaacggattt tatccttcac catacagtat tgctacaaac      840

cgaatgatca ctcaaacttc tattacaccc tatattgcat ctcctgtatc tgcctaccag      900

gtgcaaagtc cttcgtggat gcaacctcaa ccatatattc tacagcaccc tggtgccgtg      960

ttaactccct caatggagca caccatgtca ctacagcccg catcaatgat cagccctctg     1020

gcccagcaga tgagtcatct gtcactaggc agcaccggaa catacatgcc tgcaacgtca     1080

gctatgcaag gagcctactt gccacagtat gcacatatgc agacgacagc ggttcctgtt     1140

gaggaggcaa gtggtcaaca gcaggtggct gtcgagacgt ctaatgacca ttctccatat     1200

acctttcaac ctaataagta a                                               1221


<210>  1096
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  1096
atggattctg gaactcgccc agttggtagc tgctgtagca gccccgctgg gctctcacgg       60

gagtacaaac tagtgatgct gggtgctggt ggtgtaggga agagtgccat gaccatgcag      120

ttcatcagcc accgattccc agaagatcat gatcccacca ttgaagatgc ttataagatc      180

aggatccgta ttgatgatga gcctgccaat ctggacattt tggatacagc tggacaggca      240

gagtttacag ccatgcggga ccagtatatg agggcaggag aagggtttat catctgttac      300

tctatcacgg atcgtcgaag tttccatgaa gttcgtgagt ttaaacagct tatttatcga      360

gtccgacgta ctgacgatac acctgtggtt cttgtgggaa acaagtcaga cctcaaacag      420

ctaagacagg tcaccaagga agaaggattg gccttggccc gagaattcag ctgtcccttt      480

tttgagacat ctgctgcata ccgctactat attgatgatg ttttccatgc ccttgtacgg      540

gagatacgta ggaaagaaaa ggaggcagta ctggccatgg agaaaaaatc taagcccaaa      600

aacagtgtat ggaagaggct aaaatcacca ttccggaaga agaaagattc agtaacttga      660


<210>  1097
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  1097
atgggtgcat acaagtacat ccaggagcta tggagaaaga agcagtctga tgtcatgcgc       60

tttcttctga gggtccgctg ctggcagtac cgccagctct ctgctctcca cagggctccc      120

cgccccaccc ggcctgataa agcgcgccga ctgggctaca aggccaagca aggttacgtt      180

atatatagga ttcgtgttcg ccgtggtggc cgaaaacgcc cagttcctaa gggtgcaact      240

tacggcaagc ctgtccatca tggtgttaac cagctaaagt ttgctcgaag ccttcagtcc      300

gttgcagagg agcgagctgg acgccactgt ggggctctga gagtcctgaa ttcttactgg      360

gttggtgaag attccacata caaatttttt gaggttatcc tcattgatcc attccataaa      420

gctatcagaa gaaatcctga cacccagtgg atcaccaaac cagtccacaa gcacagggag      480

atgcgtgggc tgacatctgc aggccgaaag agccgtggcc ttggaaaggg ccacaagttc      540

caccacacta ttggtggctc tcgccgggca gcttggagaa ggcgcaatac tctccagctc      600

caccgttacc gctaa                                                       615


<210>  1098
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  1098
atggctcctg tgaaaaagct tgtggtgaag gggggcaaaa aaaagaagca agttctgaag       60

ttcactcttg attgcaccca ccctgtagaa gatggaatca tggatgctgc caattttgag      120

cagtttttgc aagaaaggat caaagtgaac ggaaaagctg ggaaccttgg tggaggggtg      180

gtgaccatcg aaaggagcaa gagcaagatc accgtgacat ccgaggtgcc tttctccaaa      240

aggtatttga aatatctcac caaaaaatat ttgaagaaga ataatctacg tgactggttg      300

cgcgtagttg ctaacagcaa agagagttac gaattacgtt acttccagat taaccaggac      360

gaagaagagg aggaagacga ggattaa                                          387


<210>  1099
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  1099
atgaagacta ttctcagcaa tcagactgtc gacattccag aaaatgtcga cattactctg       60

aagggacgca cagttatcgt gaagggcccc agaggaaccc tgcggaggga cttcaatcac      120

atcaatgtag aactcagcct tcttggaaag aaaaaaaaga ggctccgggt tgacaaatgg      180

tggggtaaca gaaaggaact ggctaccgtt cggactattt gtagtcatgt acagaacatg      240

atcaagggtg ttacactggg cttccgttac aagatgaggt ctgtgtatgc tcacttcccc      300

atcaacgttg ttatccagga gaatgggtct cttgttgaaa tccgaaattt cttgggtgaa      360

aaatatatcc gcagggttcg gatgagacca ggtgttgctt gttcagtatc tcaagcccag      420

aaagatgaat taatccttga aggaaatgac attgagcttg tttcaaattc agcggctttg      480

attcagcaag ccacaacagt taaaaacaag gatatcagga aatttttgga tggtatctat      540

gtctctgaaa aaggaactgt tcagcaggct gatgaataa                             579


<210>  1100
<211>  456
<212>  DNA
<213>  Homo sapiens

<400>  1100
atggcacctc gaaaggggaa ggaaaagaag gaagaacagg tcatcagcct cggacctcag       60

gtggctgaag gagagaatgt atttggtgtc tgccatatct ttgcatcctt caatgacact      120

tttgtccatg tcactgatct ttctggcaag gaaaccatct gccgtgtgac tggtgggatg      180

aaggtaaagg cagaccgaga tgaatcctca ccatatgctg ctatgttggc tgcccaggat      240

gtggcccaga ggtgcaagga gctgggtatc accgccctac acatcaaact ccgggccaca      300

ggaggaaata ggaccaagac ccctggacct ggggcccagt cggccctcag agcccttgcc      360

cgctcgggta tgaagatcgg gcggattgag gatgtcaccc ccatcccctc tgacagcact      420

cgcaggaagg ggggtcgccg tggtcgccgt ctgtga                                456


<210>  1101
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  1101
atggctcgtg gtcccaagaa gcatctgaag cgggtggcag ctccaaagca ttggatgctg       60

gataaattga ccggtgtgtt tgctcctcgt ccatccaccg gtccccacaa gttgagagag      120

tgtctccccc tcatcatttt cctgaggaac agacttaagt atgccctgac aggagatgaa      180

gtaaagaaga tttgcatgca gcggttcatt aaaatcgatg gcaaggtccg aactgatata      240

acctaccctg ctggattcat ggatgtcatc agcattgaca agacgggaga gaatttccgt      300

ctgatctatg acaccaaggg tcgctttgct gtacatcgta ttacacctga ggaggccaag      360

tacaagttgt gcaaagtgag aaagatcttt gtgggcacaa aaggaatccc tcatctggtg      420

actcatgatg cccgcaccat ccgctacccc gatcccctca tcaaggtgaa tgataccatt      480

cagattgatt tggagactgg caagattact gatttcatca agttcgacac tggtaacctg      540

tgtatggtga ctggaggtgc taacctagga agaattggtg tgatcaccaa cagagagagg      600

caccctggat cttttgacgt ggttcacgtg aaagatgcca atggcaacag ctttgccact      660

cgactttcca acatttttgt tattggcaag ggcaacaaac catggatttc tcttccccga      720

ggaaagggta tccgcctcac cattgctgaa gagagagaca aaagactggc ggccaaacag      780

agcagtgggt ga                                                          792


<210>  1102
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  1102
atggacggtc agaagaaaaa ttggaaggac aaggttgttg acctcctgta ctggagagac       60

attaagaaga ctggagtggt gtttggtgcc agcctattcc tgctgctttc attgacagta      120

ttcagcattg tgagcgtaac agcctacatt gccttggccc tgctctctgt gaccatcagc      180

tttaggatat acaagggtgt gatccaagct atccagaaat cagatgaagg ccacccattc      240

agggcatatc tggaatctga agttgctata tctgaggagt tggttcagaa gtacagtaat      300

tctgctcttg gtcatgtgaa ctgcacgata aaggaactca ggcgcctctt cttagttgat      360

gatttagttg attctctgaa gtttgcagtg ttgatgtggg tatttaccta tgttggtgcc      420

ttgtttaatg gtctgacact actgattttg gctctcattt cactcttcag tgttcctgtt      480

atttatgaac ggcatcaggc acagatagat cattatctag gacttgcaaa taagaatgtt      540

aaagatgcta tggctaaaat ccaagcaaaa atccctggat tgaagcgcaa agctgaatga      600


<210>  1103
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  1103
atgtttgtgg ctcgcagcat cgcggcggac cacaaggatc tcatccacga tgtctctttc       60

gacttccacg ggcggcggat ggcaacctgc tccagcgatc agagcgttaa ggtctgggat      120

aaaagtgaaa gtggtgattg gcattgtact gctagctgga agacacatag tggatctgta      180

tggcgtgtga catgggccca tcctgaattt gggcaggttt tggcttcctg ttcttttgac      240

cgaacagctg ctgtatggga agaaatagta ggagaatcaa atgataaact gcgaggacag      300

agccactggg ttaaaaggac aactctggtg gatagcagaa catctgttac tgatgtgaag      360

tttgctccca agcacatggg tcttatgtta gcaacctgtt ccgcagatgg tatagtaaga      420

atctatgagg caccagatgt tatgaatctc agccagtggt ctttgcagca tgagatctca      480

tgtaagctaa gctgtagttg tatttcttgg aacccttcaa gctctcgtgc tcattccccc      540

atgatcgccg taggaagtga tgacagtagc cccaacgcaa tggccaaggt tcagattttt      600

gaatataatg aaaacaccag gaaatatgca aaagctgaaa ctcttatgac agtcactgat      660

cctgttcatg atattgcatt cgctccaaat ttgggaagat ctttccatat tctagcaata      720

gcgaccaaag atgtgagaat ttttacatta aagcctgtga ggaaagaact gacttcctct      780

ggtgggccaa caaagtttga aatccatata gtggctcagt tcgataatca taattctcag      840

gtctggcgag tgagttggaa tataacagga acggtgctag catcttcagg agatgatggg      900

tgtgtaagat tgtggaaagc taattatatg gacaattgga agtgtactgg tattttgaaa      960

ggtaatggga gcccagtcaa tgggagttct cagcagggaa cctcaaatcc ttccctaggt     1020

tcaactattc caagtcttca gaattcatta aatggatctt ctgctggcag aaagcacagc     1080

tga                                                                   1083


<210>  1104
<211>  1164
<212>  DNA
<213>  Homo sapiens

<400>  1104
atgcctgggc acttacagga aggcttcggc tgcgtggtca ccaaccgatt cgaccagtta       60

tttgacgacg aatcggaccc cttcgaggtg ctgaaggcag cagagaacaa gaaaaaagaa      120

gccggcgggg gcggcgttgg gggccctggg gccaagagcg cagctcaggc cgcggcccag      180

accaactcca acgcggcagg caaacagctg cgcaaggagt cccagaaaga ccgcaagaac      240

ccgctgcccc ccagcgttgg cgtggttgac aagaaagagg agacgcagcc gcccgtggcg      300

cttaagaaag aaggaataag acgagttgga agaagacctg atcaacaact tcagggtgaa      360

gggaaaataa ttgatagaag accagaaagg cgaccacctc gtgaacgaag attcgaaaag      420

ccacttgaag aaaagggtga aggaggcgaa ttttcagttg atagaccgat tattgaccga      480

cctattcgag gtcgtggtgg tcttggaaga ggtcgagggg gccgtggacg tggaatgggc      540

cgaggagatg gatttgattc tcgtggcaaa cgtgaatttg ataggcatag tggaagtgat      600

agatctggcc tgaagcacga ggacaaacgt ggaggtagcg gatctcacaa ctggggaact      660

gtcaaagacg aattaactga cttggatcaa tcaaatgtga ctgaggaaac acctgaaggt      720

gaagaacatc atccagtggc agacactgaa aataaggaga atgaagttga agaggtaaaa      780

gaggagggtc caaaagagat gactttggat gagtggaagg ctattcaaaa taaggaccgg      840

gcaaaagtag aatttaatat ccgaaaacca aatgaaggtg ctgatgggca gtggaagaag      900

ggatttgttc ttcataaatc aaagagtgaa gaggctcatg ctgaagattc ggttatggac      960

catcatttcc ggaagccagc aaatgatata acgtctcagc tggagatcaa ttttggagac     1020

cttggccgcc caggacgtgg cggcagggga ggacgaggtg gacgtgggcg tggtgggcgc     1080

ccaaaccgtg gcagcaggac cgacaagtca agtgcttctg ctcctgatgt ggatgaccca     1140

gaggcattcc cagctctggc ttaa                                            1164


<210>  1105
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  1105
atggagcagc tgagctcagc aaacacccgc ttcgccttgg acctgttcct ggcgttgagt       60

gagaacaatc cggctggaaa catcttcatc tctcccttca gcatttcatc tgctatggcc      120

atggtttttc tggggaccag aggtaacacg gcagcacagc tgtccaagac tttccatttc      180

aacacggttg aagaggttca ttcaagattc cagagtctga atgctgatat caacaaacgt      240

ggagcgtctt atattctgaa acttgctaat agattatatg gagagaaaac ttacaatttc      300

cttcctgagt tcttggtttc gactcagaaa acatatggtg ctgacctggc cagtgtggat      360

tttcagcatg cctctgaaga tgcaaggaag accataaacc agtgggtcaa aggacagaca      420

gaaggaaaaa ttccggaact gttggcttcg ggcatggttg ataacatgac caaacttgtg      480

ctagtaaatg ccatctattt caagggaaac tggaaggata aattcatgaa agaagccacg      540

acgaatgcac cattcagatt gaataagaaa gacagaaaaa ctgtgaaaat gatgtatcag      600

aagaaaaaat ttgcatatgg ctacatcgag gaccttaagt gccgtgtgct ggaactgcct      660

taccaaggcg aggagctcag catggtcatc ctgctgccgg atgacattga ggacgagtcc      720

acgggcctga agaagattga ggaacagttg actttggaaa agttgcatga gtggactaaa      780

cctgagaatc tcgatttcat tgaagttaat gtcagcttgc ccaggttcaa actggaagag      840

agttacactc tcaactccga cctcgcccgc ctaggtgtgc aggatctctt taacagtagc      900

aaggctgatc tgtctggcat gtcaggagcc agagatattt ttatatcaaa aattgtccac      960

aagtcatttg tggaagtgaa tgaagaggga acagaggcgg cagctgccac agcaggcatc     1020

gcaactttct gcatgttgat gcccgaagaa aatttcactg ccgaccatcc attccttttc     1080

tttattcggc ataattcctc aggtagcatc ctattcttgg ggagattttc ttccccttag     1140


<210>  1106
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  1106
atgttgggta aaggaggaaa acggaagttt gatgagcatg aagatgggct ggaaggcaaa       60

atcgtgtctc cctgtgacgg tccatccaag gtgtcttaca ccttacagcg ccagactatc      120

ttcaacattt cccttatgaa actctataac cacaggcccc tgacagagcc cagcttgcaa      180

aagaccgttt taattaacaa catgttgagg cggatccagg aggaactcaa acaggaaggc      240

agcctgaggc ccatgttcac cccctcctcc cagcccacca ccgagcccag cgacagctac      300

cgagaggccc cgccggcctt cagccacctg gcgtccccgt cctcccaccc ctgcgacctc      360

ggaagcacta cgcccctgga ggcctgcctc accccggcct cactgctcga ggacgacgat      420

gacacgtttt gcacctccca ggccatgcag cccacggctc ccaccaaact gtcacctcca      480

gccctcttgc cagaaaagga cagtttctcc tctgccttgg acgagatcga ggagctctgt      540

cccacatcta cctccacaga ggcggccacg gctgcgactg acagtgtgaa agggacctcc      600

agcgaggctg gcacccagaa actcgacggt cctcaagaga gccgcgcaga tgactcaaaa      660

ctgatggact ctctgcctgg gaattttgaa ataacgacgt ccacgggttt cctgacagac      720

ttgaccctgg atgacatcct gtttgctgac attgatacgt ccatgtatga ttttgacccc      780

tgcacttcct catcagggac agcctcaaaa atggcccctg tgtctgccga cgacctcctc      840

aaaactctgg ctccttacag cagtcagcct gtcaccccaa gtcagccttt caaaatggac      900

ctcacagagc tggaccacat catggaggtg cttgttgggt cctaa                      945


<210>  1107
<211>  8034
<212>  DNA
<213>  Homo sapiens

<400>  1107
atgagcacat gttgttggtg tacgccaggt ggtgcttcca ccattgactt cctaaagcgc       60

tatgcttcca acactccgtc cggtgaattt caaacagccg acgaagacct ctgctactgc      120

ttggagtgtg tggctgagta ccacaaagca agagatgaat tgccattctt gcatgaggtt      180

ttatgggaat tagaaacctt acgtctcata aatcactttg aaaaatccat gaaggcagaa      240

attggagatg atgatgagtt atatatagta gacaataatg gagagatgcc actgtttgac      300

atcactgggc aagactttga aaataagctt cgagttcctc ttcttgaaat actgaaatat      360

ccttacttgc ttctacatga acgtgttaac gagttatgtg ttgaagcact ttgtcggatg      420

gaacaagcca attgctcctt tcaggtgttt gataaacatc cagggatcta tttgttttta      480

gtccatccca atgaaatggt tcggcgttgg gctatcttga ctgcaagaaa cttggggaaa      540

gtggacagag atgattatta tgacttacaa gaagttttac tttgcctttt taaagtcatt      600

gagttggggc ttttagagag tccagacatt tatacttctt ctgtcctaga gaagggtaaa      660

ctgattcttc tgccctcaca catgtatgat actaccaact acaaaagcta ttggttaggt      720

atttgcatgt tgctgaccat tcttgaggaa caagccatgg attccctgtt gttgggctca      780

gacaaacaaa atgattttat gcaatcgata cttcacacta tggagaggga agcagatgat      840

gatagtgtgg atcctttctg gccagcgtta cactgtttta tggtgattct ggatcgcctt      900

ggatctaagg tctggggtca acttatggat cctattgtgg catttcaaac cattatcaac      960

aacgcaagct acaatagaga gatccgacat atacggaaca gctctgtaag gaccaagtta     1020

gaaccggagt cctatttgga tgatatggtg acttgcagcc agatcgtata caattataat     1080

cctgaaaaga ccaaaaagga ttctggatgg agaacagcca tttgcccaga ttattgtcct     1140

aacatgtatg aagaaatgga aacattagcc agtgtacttc agtcagatat tggtcaagac     1200

atgcgtgttc ataacagcac atttctatgg ttcatccctt ttgtccagtc cctcatggat     1260

cttaaggatt tgggtgtggc ttacatagca caggttgtta atcatctgta ctctgaagtc     1320

aaagaagtcc tcaaccaaac agatgctgtg tgtgacaaag tcactgaatt ttttcttcta     1380

attttggtat cagtgattga actgcataga aataaaaaat gtttgcattt gctgtgggta     1440

agttcccagc aatgggtgga agccgtcgtc aaatgtgcca agcttcctac cactgcgttt     1500

acacggagtt ctgagaaatc atctggaaat tgctccaaag gaacagcaat gatatcttca     1560

ctgtcattgc attccatgcc atctaactct gtacaacttg cttatgtgca gctgattaga     1620

agtctcctta aagaaggtta tcagcttggg cagcagtctc tttgcaagcg attctgggat     1680

aagctcaact tattccttag aggaaattta tctctaggtt ggcagttgac tagtcaggaa     1740

acccatgagc tacaaagttg cttaaagcaa attattagaa acataaaatt caaagcacct     1800

ccatgtaaca cttttgtgga tctgacttct gcatgtaaaa tctctcctgc atcttataat     1860

aaagaagaaa gtgaacaaat ggggaagacg tctagaaaag atatgcattg tttggaagct     1920

tccagcccaa cattttctaa agaaccaatg aaagtgcaag acagtgtatt gatcaaagca     1980

gataacacta tagaaggtga caataatgag caaaattata taaaggatgt gaaactagag     2040

gaccatctct tagctgggtc atgcttaaag cagagtagta aaaacatttt tactgaaaga     2100

gctgaagatc aaattaaaat aagtacaagg aagcagaagt ctgtaaaaga gatctcttca     2160

tatacaccaa aggactgtac ttcaagaaat ggtccagaaa ggggatgtga cagaggaata     2220

atagtatcaa cacgtttgtt gactgattct agcactgatg ctttggaaaa agtgtccaca     2280

tcgaatgaag atttctcttt aaaggatgat gctcttgcta aaacctcaaa acgaaaaact     2340

aaggtacaga aagatgaaat ctgtgcaaag ttatcacatg taataaagaa gcaacacagg     2400

aagagtactt tggtcgataa tactatcaat ttagatgaaa atttgactgt atctaacatt     2460

gagagtttct attcaaggaa agatacagga gttcagaaag gagatggttt catacacaat     2520

ctttctttag accctagtgg tgttctggat gataagaatg gagaacaaaa atctcaaaac     2580

aatgtattgc caaaagagaa acaattaaag aatgaagaat tagttatttt ctctttccat     2640

gaaaacaatt gtaaaataca ggaatttcat gttgatggta aagaattgat cccttttaca     2700

gaaatgacca atgcttcaga gaagaaatca tctcccttta aagatcttat gactgtacct     2760

gaatcaagag atgaggagat gagtaatagt accagtgtga tttattctaa cttgacaaga     2820

gaacaggccc ctgacatcag tcctaaatct gacaccttaa cggattctca gatagacaga     2880

gaccttcaca aattatcttt actagctcaa gccagtgtta ttacgttccc atccgattca     2940

cctcagaact catcgcagct gcaaaggaaa gtaaaagaag ataaaagatg tttcacagct     3000

aaccaaaata atgttggaga tacctcccgt ggacaggtta ttattatttc agattctgat     3060

gatgatgatg atgaaagaat cctgagtctt gagaaactca ctaaacagga caaaatatgc     3120

cttgagaggg aacatccaga gcagcacgtt tcaacagtta atagtaagga ggaaaagaat     3180

ccagtaaagg aagaaaagac agagactctt tttcagtttg aggaatctga ttctcagtgt     3240

tttgagtttg aaagttcatc tgaagtgttt tcagtttggc aagatcatcc agacgataat     3300

aattcagttc aagatggtga gaaaaaatgt ttggctccta tagccaatac tacaaatggt     3360

cagggttgta cagattatgt atctgaagtt gttaaaaaag gagcagaggg cattgaagaa     3420

cacacaagac cacggagtat ttctgttgaa gaattttgtg aaattgaagt aaaaaagcct     3480

aagagaaaac gatctgaaaa accaatggct gaagatcctg tgaggccttc atcttctgtc     3540

agaaatgagg gccagtctga tactaataag agagatcttg tgggaaatga ttttaaaagt     3600

attgatagaa ggacttcaac tcccaattca cgtattcaga gagccactac ggtttcacaa     3660

aagaagtctt caaagctttg tacttgtaca gaacccatca ggaaagttcc agtttctaag     3720

acccctaaga aaactcattc agatgccaaa aaaggacaga atagaagttc aaattaccta     3780

agttgtagaa caactcctgc tatagtgccg ccaaagaaat ttcgtcagtg tcctgagcca     3840

acttcaacag ctgagaaact tggcctgaaa aagggtcctc gtaaggcata tgagttgtcc     3900

cagcggtctt tggattatgt agctcaatta cgtgatcatg gcaaaactgt tggagtagtt     3960

gatacccgaa aaaagactaa attaatttct cctcagaacc tgtctgtcag aaataataag     4020

aaacttctga ctagtcaaga acttcagatg caaaggcaga tcagacccaa atcacaaaaa     4080

aatagacgaa gactttctga ttgtgaaagt acagatgtta aaagagcagg gtcacataca     4140

gcacagaatt ctgacatatt tgtaccagaa tctgataggt cagattataa ttgtacagga     4200

ggaactgagg tacttgccaa cagtaacaga aaacagttaa taaaatgcat gccttctgaa     4260

ccagaaacca taaaagcaaa acatgggtct ccagcaactg atgatgcttg ccctttgaac     4320

cagtgtgatt ctgtagtgtt aaatggaaca gtaccaacaa atgaagtaat tgtctccact     4380

tcagaagacc ctctgggtgg aggtgatcca acagcacgtc atatagagat ggcagctttg     4440

aaagaaggag agcctgactc cagcagtgat gcagaggaag ataacttatt tttaacccaa     4500

aatgatcctg aagatatgga tttatgttca caaatggaga atgacaatta taaactcatt     4560

gaactaattc atggaaaaga tacagttgag gttgaagaag attctgtaag tcggcctcag     4620

ttggaatctt tgagtggcac aaagtgtaag tacaaagatt gtcttgaaac cacaaaaaac     4680

cagggtgaat actgcccaaa acactctgaa gtgaaagcag cagatgaaga tgtatttcgt     4740

aaacctggct tgcctcctcc tgcatctaaa cctttgagac ctaccactaa gatttttagc     4800

tcaaagagta cttcacgaat tgctggtctt tctaaatctt tggaaacttc ttcagcactt     4860

tcaccgtctc taaaaaataa gtcaaagggg atacagtcga ttttgaaagt accacagcca     4920

gttcccctca tagctcagaa gccagttggt gaaatgaaga attcgtgcaa tgttcttcat     4980

cctcagtctc cgaataattc caacaggcaa ggttgcaaag ttccatttgg tgaaagcaaa     5040

tattttccat cttcctctcc agtaaacatt cttttgtcat cacagtctgt ctctgacacc     5100

ttcgttaaag aggtcttaaa atggaaatat gaaatgtttt tgaactttgg tcagtgtggg     5160

ccccctgcaa gtctttgtca gtccatctca agacctgtgc ctgtcagatt tcacaattat     5220

ggagattatt ttaatgtttt tttccctttg atggtattga atacttttga aacagtggca     5280

caagaatggc tcaactctcc aaatagagag aatttctatc agttgcaagt acgaaaattt     5340

cctgccgatt atataaaata ctgggagttt gcagtttatc tggaagaatg tgaactggct     5400

aaacagcttt atccaaagga aaacgatttg gtgtttttag ctcctgagag aataaatgaa     5460

gagaagaaag atacagagag aaatgacata caagatctcc acgaatatca ttctggttat     5520

gttcataaat ttcgccgcac gtcagtcatg cgtaatggga aaactgagtg ttacctttcc     5580

atccagactc aagagaactt tccggccaat ttaaacgaac ttgtgaattg tattgtaatc     5640

agttctctgg taactacaca aaggaagttg aaagccatgt ctctgttggg tagtcggaac     5700

caactggcta gagctgttct gaatccaaac cctatggact tctgtacaaa agatttactg     5760

actacaacat ctgagagaat tattgcgtac ttaagagatt tcaatgaaga tcaaaagaaa     5820

gcaatagaaa ctgcatatgc tatggtgaaa cactcaccat cagttgccaa aatctgcttg     5880

attcatggac cacctggaac aggaaaatca aaaactattg ttggcctcct ctatcgtcta     5940

ctgacagaga accagaggaa ggggcattca gacgaaaact ccaatgccaa aatcaaacaa     6000

aaccgtgtcc tcgtgtgtgc accttccaat gcagctgttg atgaactcat gaaaaaaatt     6060

atccttgaat tcaaagaaaa atgtaaagac aagaagaatc ctttaggaaa ctgtggagat     6120

ataaatttag tacgactggg tccagaaaag tctattaata gtgaggttct aaagttcagt     6180

ttggacagcc aagtaaacca cagaatgaaa aaagagttac cttctcatgt tcaggcgatg     6240

cataaaagaa aggaatttct agattatcag ctggatgagc tttcccggca gcgagctcta     6300

tgccgaggtg gacgggaaat acagaggcaa gaattagatg aaaacatttc caaagtttct     6360

aaggaaaggc aggaacttgc ttctaaaatt aaagaggttc aaggacgccc acagaaaaca     6420

cagagtatca tcatcttaga gtcccatatc atctgctgca cgttgagcac aagtggtggt     6480

ttactacttg agtctgcttt ccgtgggcaa gggggtgtcc ccttcagctg tgtcattgtt     6540

gatgaggctg gacagtcttg tgaaattgag actcttactc cactcatcca tcgctgcaat     6600

aagctcatcc tagtaggaga tcctaagcag ctccctccga cagtcatctc tatgaaagca     6660

caggagtatg gctacgacca gtcaatgatg gctcgcttct gcagactgct ggaagagaat     6720

gtagaacaca acatgatcag caggctgccc attctacagc tcactgttca gtacaggatg     6780

catccagaca tatgcctctt cccttctaat tatgtttata acagaaactt aaaaacaaat     6840

agacagacag aagccattcg atgttcatca gattggccat ttcagccata ccttgtgttt     6900

gatgttggag atggttcaga aagacgggat aatgactcat atataaatgt tcaagaaata     6960

aaactggtga tggaaataat taagcttatt aaagacaaaa gaaaggatgt tagttttcga     7020

aacattggca taataactca ttacaaggcc cagaagacga tgattcagaa ggatttggac     7080

aaagagttcg atagaaaagg accagcagaa gtagacactg tggatgcatt ccagggtcgg     7140

cagaaggatt gtgttattgt tacgtgtgtc agagcaaata gcatccaagg ttcaattgga     7200

ttcctggcaa gtttgcagag attgaatgtc accatcacac gagccaagta cagcctcttc     7260

atcctcggac atttgaggac cctgatggaa aaccagcatt ggaatcagct gattcaggat     7320

gctcagaagc gtggtgccat tattaagacc tgtgacaaaa actatagaca tgatgcagtg     7380

aagattctga aactcaagcc tgtgctgcag agaagtctca ctcaccctcc taccatagcc     7440

ccagaggggt ccagacccca gggtggtttg cccagcagca agctagacag tggatttgcc     7500

aagacatctg ttgctgcttc tctataccac acaccctctg actccaagga aattactctt     7560

actgttactt caaaggaccc tgaaagacct cctgttcatg accaacttca ggacccacga     7620

ctgctgaaga ggatgggcat tgaggtcaaa ggaggaatat tcctttggga tccacaaccc     7680

tcgagccccc agcatcctgg agcaacacct cctacgggcg agccgggctt ccctgtcgtt     7740

caccaggacc tgagccatat acagcagccc gctgctgtag tggctgctct gagcagccac     7800

aaacctcccg tgcggggcga acctccagct gccagtcccg aggcttccac gtgtcagagc     7860

aaatgtgatg acccggaaga ggagctctgt cacaggagag aggccagggc tttcagtgaa     7920

ggggagcagg agaagtgtgg ttccgagacc catcacacca ggaggaactc taggtgggac     7980

aagaggacac tggagcagga ggacagcagt tccaagaaaa gaaagctttt atag           8034


<210>  1108
<211>  1098
<212>  DNA
<213>  Homo sapiens

<400>  1108
atgaatatca tggacttcaa cgtgaagaag ctggcggccg acgcaggcac cttcctcagt       60

cgcgccgtgc agttcacaga agaaaagctt ggccaggctg agaagacaga attggatgct      120

cacttagaga acctccttag caaagctgaa tgtaccaaaa tatggacaga aaaaataatg      180

aaacaaactg aagtgttatt gcagccaaat ccaaatgcca ggatagaaga atttgtttat      240

gagaaactgg atagaaaagc tccaagtcgt ataaacaacc cagaactttt gggacaatat      300

atgattgatg cagggactga gtttggccca ggaacagctt atggtaatgc ccttattaaa      360

tgtggagaaa cccaaaaaag aattggaaca gcagacagag aactgattca aacgtcagcc      420

ttaaattttc ttactccttt aagaaacttt atagaaggag attacaaaac aattgctaaa      480

gaaaggaaac tattgcaaaa taagagactg gatttggatg ctgcaaaaac gagactaaaa      540

aaggcaaaag ctgcagaaac tagaaattca tctgaacagg aattaagaat aactcaaagt      600

gaatttgatc gtcaagcaga gattaccaga cttctgctag agggaatcag cagtacacat      660

gcccatcacc ttcgctgtct gaatgacttt gtagaagccc agatgactta ctatgcacag      720

tgttaccagt atatgttgga cctccagaaa caactgggaa gttttccatc caattatctt      780

agtaacaaca atcagacttc tgtgacacct gtaccatcag ttttaccaaa tgcgattggt      840

tcttctgcca tggcttcaac aagtggccta gtaatcacct ctccttccaa cctcagtgac      900

cttaaggagt gtagtggcag cagaaaggcc agggttctct atgattatga tgcagcaaac      960

agtactgaat tatcacttct ggcagatgag gtgatcactg tgttcagtgt tgttggaatg     1020

gattcagact ggctaatggg ggaaagggga aaccagaagg gcaaggtgcc aattacctac     1080

ttagaactgc tcaattaa                                                   1098


<210>  1109
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  1109
atggctggtt ccccaacatg cctcaccctc atctatatcc tttggcagct cacagggtca       60

gcagcctctg gacccgtgaa agagctggtc ggttccgttg gtggggccgt gactttcccc      120

ctgaagtcca aagtaaagca agttgactct attgtctgga ccttcaacac aacccctctt      180

gtcaccatac agccagaagg gggcactatc atagtgaccc aaaatcgtaa tagggagaga      240

gtagacttcc cagatggagg ctactccctg aagctcagca aactgaagaa gaatgactca      300

gggatctact atgtggggat atacagctca tcactccagc agccctccac ccaggagtac      360

gtgctgcatg tctacgagca cctgtcaaag cctaaagtca ccatgggtct gcagagcaat      420

aagaatggca cctgtgtgac caatctgaca tgctgcatgg aacatgggga agaggatgtg      480

atttatacct ggaaggccct ggggcaagca gccaatgagt cccataatgg gtccatcctc      540

cccatctcct ggagatgggg agaaagtgat atgaccttca tctgcgttgc caggaaccct      600

gtcagcagaa acttctcaag ccccatcctt gccaggaagc tctgtgaagg tgctgctgat      660

gacccagatt cctccatggt cctcctgtgt ctcctgttgg tgcccctcct gctcagtctc      720

tttgtactgg ggctatttct ttggtttctg aagagagaga gacaagaaga gtacattgaa      780

gagaagaaga gagtggacat ttgtcgggaa actcctaaca tatgccccca ttctggagag      840

aacacagagt acgacacaat ccctcacact aatagaacaa tcctaaagga agatccagca      900

aatacggttt actccactgt ggaaataccg aaaaagatgg aaaatcccca ctcactgctc      960

acgatgccag acacaccaag gctatttgcc tatgagaatg ttatctag                  1008


<210>  1110
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  1110
atggtcaccc acagcaagtt tcccgccgcc gggatgagcc gccccctgga caccagcctg       60

cgcctcaaga ccttcagctc caagagcgag taccagctgg tggtgaacgc agtgcgcaag      120

ctgcaggaga gcggcttcta ctggagcgca gtgaccggcg gcgaggcgaa cctgctgctc      180

agtgccgagc ccgccggcac ctttctgatc cgcgacagct cggaccagcg ccacttcttc      240

acgctcagcg tcaagaccca gtctgggacc aagaacctgc gcatccagtg tgaggggggc      300

agcttctctc tgcagagcga tccccggagc acgcagcccg tgccccgctt cgactgcgtg      360

ctcaagctgg tgcaccacta catgccgccc cctggagccc cctccttccc ctcgccacct      420

actgaaccct cctccgaggt gcccgagcag ccgtctgccc agccactccc tgggagtccc      480

cccagaagag cctattacat ctactccggg ggcgagaaga tccccctggt gttgagccgg      540

cccctctcct ccaacgtggc cactcttcag catctctgtc ggaagaccgt caacggccac      600

ctggactcct atgagaaagt cacccagctg ccggggccca ttcgggagtt cctggaccag      660

tacgatgccc cgctttaa                                                    678


<210>  1111
<211>  2496
<212>  DNA
<213>  Homo sapiens

<400>  1111
atggagcggc cctggggagc tgcggacggc ctctcgcgct ggccccatgg cctcggcctc       60

ctcctcctcc tgcagctgct gccgccgtcg accctcagcc aggaccggct ggacgcgccg      120

ccgccgcccg ctgcgccgct gccgcgctgg tctggcccca tcggggtgag ctgggggctg      180

cgggcggccg cagccggggg cgcgtttccc cgcggcggcc gttggcgtcg cagcgcgccg      240

ggcgaggacg aggagtgcgg ccgggtccgg gacttcgtcg ccaagctggc caacaacacg      300

caccagcatg tgtttgatga tctcagaggc tcagtatcct tgtcctgggt tggagatagc      360

actggggtca ttctagtctt gactaccttc catgtaccac tggtaattat gacttttgga      420

cagtccaagc tatatcgaag tgaggattat gggaagaact ttaaggatat tacagatctc      480

atcaataaca cctttattcg gactgaattt ggcatggcta ttggtcctga gaactctgga      540

aaggtggtgt taacagcaga ggtgtctgga ggaagtcgtg gaggaagaat ctttagatca      600

tcagattttg cgaagaattt tgtgcaaaca gatctccctt ttcatcctct cactcagatg      660

atgtatagcc ctcagaattc tgattatctt ttagctctca gcactgaaaa tggcctgtgg      720

gtgtccaaga attttggggg aaaatgggaa gaaatccaca aagcagtatg tttggccaaa      780

tggggatcag acaacaccat cttctttaca acctatgcaa atggctcctg caaagctgac      840

cttggggctc tggaattatg gagaacttca gacttgggaa aaagcttcaa aactattggt      900

gtgaaaatct actcatttgg tcttggggga cgtttccttt ttgcctctgt gatggctgat      960

aaggatacaa caagaaggat ccacgtttca acagatcaag gggacacatg gagcatggcc     1020

cagctcccct ccgtgggaca ggaacagttc tattctattc tggcagcaaa tgatgacatg     1080

gtattcatgc atgtagatga acctggagac actgggtttg gcacaatctt tacctcagat     1140

gatcgaggca ttgtctattc caagtctttg gaccgacatc tctacactac cacaggcgga     1200

gagacggact ttaccaacgt gacctccctc cgcggcgtct acataacaag cgtgctctcc     1260

gaagataatt ctatccagac catgatcact tttgaccaag gaggaaggtg gacgcacctg     1320

aggaagcctg aaaacagtga atgtgatgct acagcaaaaa acaagaatga gtgcagcctt     1380

catattcatg cttcctacag catctcccag aaactgaatg ttccaatggc cccactctca     1440

gagccgaatg ccgtaggcat tgtcattgct catggtagcg tgggggatgc catctcagtg     1500

atggttccag atgtgtacat ctcagatgat gggggttact cctggacaaa gatgctggaa     1560

ggaccccact attacaccat cctggattct ggaggcatca ttgtggccat tgagcacagc     1620

agccgtccta tcaatgtgat taagttctcc acagacgaag gtcaatgctg gcaaacctac     1680

acgttcacca gggaccccat ctatttcact ggcctagctt cagaacctgg agctaggtcc     1740

atgaatatca gcatttgggg cttcacagaa tctttcctga ccagccagtg ggtctcctac     1800

accattgatt ttaaagatat ccttgaaagg aactgtgaag agaaggacta taccatatgg     1860

ctggcacact ccacagaccc tgaagattat gaagatggct gcattttggg ctacaaagaa     1920

cagtttctgc ggctacgcaa gtcatccgtg tgtcagaatg gtcgagacta tgttgtgacc     1980

aagcagccct ccatctgcct ctgttccctg gaggactttc tctgtgattt tggctactac     2040

cgtccagaaa atgactccaa gtgtgtggaa cagccagaac tgaagggcca cgacctggag     2100

ttttgtctgt acggaagaga agaacaccta acaacaaatg ggtaccggaa aattccaggg     2160

gacaaatgcc agggtggggt aaatccagtt cgagaagtaa aagacttgaa aaagaaatgc     2220

acaagcaact ttttgagtcc ggaaaaacag aattccaagt caaattctgt tccaattatc     2280

ctggccatcg tgggattgat gctggtcaca gtcgtagcag gagtgctcat tgtgaagaaa     2340

tatgtctgtg ggggaaggtt cctggtgcat cgatactctg tgctgcagca gcatgcagag     2400

gccaatggtg tggatggtgt ggatgctttg gacacagcct cccacactaa taaaagtggt     2460

tatcatgatg actcagatga ggacctcttg gaatag                               2496


<210>  1112
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  1112
atgttacagg cgtgcaaaat ggaagggttt cccctcgtcc cccctccatc agaagacctg       60

gtgccctatg acacggatct ataccaacgc caaacgcacg agtattaccc ctatctcagc      120

agtgatgggg agagccatag cgaccattac tgggacttcc acccccacca cgtgcacagc      180

gagttcgaga gcttcgccga gaacaacttc acggagctcc agagcgtgca gcccccgcag      240

ctgcagcagc tctaccgcca catggagctg gagcagatgc acgtcctcga tacccccatg      300

gtgccacccc atcccagtct tggccaccag gtctcctacc tgccccggat gtgcctccag      360

tacccatccc tgtccccagc ccagcccagc tcagatgagg aggagggcga gcggcagagc      420

cccccactgg aggtgtctga cggcgaggcg gatggcctgg agcccgggcc tgggctcctg      480

cctggggaga caggcagcaa gaagaagatc cgcctgtacc agttcctgtt ggacctgctc      540

cgcagcggcg acatgaagga cagcatctgg tgggtggaca aggacaaggg caccttccag      600

ttctcgtcca agcacaagga ggcgctggcg caccgctggg gcatccagaa gggcaaccgc      660

aagaagatga cctaccagaa gatggcgcgc gcgctgcgca actacggcaa gacgggcgag      720

gtcaagaagg tgaagaagaa gctcacctac cagttcagcg gcgaagtgct gggccgcggg      780

ggcctggccg agcggcgcca cccgccccac tga                                   813


<210>  1113
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  1113
atggtgccac tggtggctgt ggtatcaggg ccccgtgccc agctctttgc ctgcctgctc       60

aggctgggca ctcagcaggt cggccccctt cagctgcaca ccggggccag ccatgcggcc      120

aggaaccatt atgaggtgct ggtgctgggt gggggcagtg gcggaatcac catggctgcc      180

cgcatgaaga ggaaagtggg tgcagagaat gtggccattg ttgagcccag tgagagacat      240

ttctaccagc caatctggac actggtgggt gctggtgcca aacaattgtc ctcatctggt      300

cgtcccacgg caagtgtgat tccatctggt gtagaatgga tcaaagctag agtgactgag      360

ttgaacccag acaagaactg cattcacaca gatgacgacg agaagatctc ctaccgatat      420

cttattattg ctctcggaat ccagctggac tatgagaaga ttaaaggcct acctgaaggt      480

ttcgctcatc ccaaaatagg gtcgaattat tcagttaaga ctgtagagaa gacatggaaa      540

gctctgcagg acttcaaaga gggcaatgcc atcttcacct tcccaaatac tccagtgaag      600

tgtgctggag cccctcagaa gatcatgtac ttatcagaag cctacttcag gaagacaggg      660

aagcgatcca aggccaatat cattttcaac acttctcttg gagccatttt cggggttaag      720

aagtatgcag atgccctgca ggagatcatc caggagcgga acctcactgt taactacaag      780

aaaaacctca ttgaagtccg agccgataaa caagaggctg tatttgagaa cctggacaaa      840

ccaggagaga cccaagtgat ttcatatgaa atgcttcatg tcacacctcc aatgagccca      900

ccagatgtcc tcaagaccag tcctgtggct gatgctgctg gttgggtgga tgtggataaa      960

gaaactctgc aacacaggag gtacccaaat gtgtttggga ttggggactg caccaacctt     1020

cctacgtcaa agaccgctgc tgcagtagct gcccagtcag gaatacttga taggacaatt     1080

tctgtaatta tgaagaatca aacaccaaca aagaagtatg atggctacac atcatgtcca     1140

ctggtgaccg gctacaaccg tgtgattctt gctgagtttg actacaaagc agagccgcta     1200

gaaaccttcc cctttgatca aagcaaagag cgcctttcca tgtatctcat gaaagctgac     1260

ctgatgcctt tcctgtattg gaatatgatg ctaaggggtt actggggagg accagcgttt     1320

ctgcgcaagt tgtttcatct aggtatgagt taa                                  1353


<210>  1114
<211>  2310
<212>  DNA
<213>  Homo sapiens

<400>  1114
atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag       60

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      120

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      180

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      240

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      300

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      360

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      420

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      480

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      540

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      600

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      660

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      720

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta      780

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa      840

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag      900

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc      960

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1020

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1080

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1140

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1200

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1260

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc     1320

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1380

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1440

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1500

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1560

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1620

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1680

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1740

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     1800

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     1860

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     1920

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     1980

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2040

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggc     2100

gctgccccat acctgaagac caagtttatc tgtgtgacac caacgacctg cagcaatacc     2160

attgacctgc cgatgtcccc ccgcacttta gattcattga tgcagtttgg aaataatggt     2220

gaaggtgctg aaccctcagc aggagggcag tttgagtccc tcacctttga catggagttg     2280

acctcggagt gcgctacctc ccccatgtga                                      2310


<210>  1115
<211>  1299
<212>  DNA
<213>  Homo sapiens

<400>  1115
atggcgtccc ccgtagcagc gcaggccggg aagcttctgc gagccctagc gctgcggccc       60

cgcttcctgg cggccgggtc ccaggcagtt caattaacct ccagaagatg gctgaacctg      120

caggaatacc agagcaagaa actgatgtct gacaacggag tgagagttca aagattcttt      180

gtagcagaca ctgcaaatga agctctcgag gctgctaaga gactaaatgc aaaagaaatt      240

gttttaaaag cccagatctt agctggagga agaggaaaag gtgtcttcaa tagtggtttg      300

aaaggaggtg ttcatttaac aaaagaccct aatgttgtgg gacagctggc taaacagatg      360

attgggtaca atctagcgac aaaacaaact ccaaaagaag gtgtgaaagt taacaaggtg      420

atggttgctg aagccttgga tatttccaga gaaacctacc tggcaattct gatggaccgg      480

tcctgcaatg gccccgtgct ggtgggcagc ccccaggggg gcgtcgacat tgaagaggtg      540

gctgcttcaa acccggagct catttttaag gagcaaattg acatttttga aggaataaag      600

gacagccaag ctcagcggat ggccgaaaat ctaggcttcg ttgggccttt gaaaagccag      660

gctgcagatc aaattacgaa gctgtataat ctcttcctga aaattgatgc tactcaggtg      720

gaagtgaatc cctttggtga aactccagaa ggacaagttg tctgttttga tgccaagata      780

aactttgatg acaacgcaga attccgacaa aaagacatat ttgctatgga cgacaaatca      840

gagaatgagc ccattgaaaa tgaagctgcc aaatatgatc taaaatacat aggactagat      900

gggaacattg cctgctttgt gaatggtgct gggctcgcca tggctacttg tgatatcatt      960

ttccttaatg gtgggaagcc agccaacttc ttggatcttg gaggtggtgt aaaggaagct     1020

caagtatatc aagcattcaa attgctcaca gctgatccta aggttgaagc catccttgtc     1080

aatatatttg gtggtatcgt caactgtgcc atcattgcca atgggatcac caaagcctgc     1140

cgggagctag aactcaaggt gcccctggtg gtccggcttg aaggaaccaa cgtccaagag     1200

gcccagaaga tactcaacaa cagcggactc cccattactt cagccattga cctggaggat     1260

gcagccaaga aggctgtggc cagtgtggcc aagaagtga                            1299


<210>  1116
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  1116
atggataaaa acattggcga gcaactcaat aaagcgtatg aagccttccg gcaggcatgc       60

atggatagag attctgcagt aaaagaatta cagcaaaaga ctgagaacta tgagcagaga      120

atacgtgaac aacaggaaca gctgtcactt caacagacta ttattgacaa gctaaaatct      180

cagttacttc ttgtgaattc cactcaagat aacaattatg gctgtgttcc tctgcttgaa      240

gacagtgaaa caagaaagaa taatttgact cttgatcagc cacaagataa agtgatttca      300

ggaatagcaa gagaaaaact accaaaggta agaagacaag aggtttcttc tcctagaaaa      360

gaaacttcag caaggagtct tggcagtcct ttgctccatg aaaggggtaa tatagagaag      420

actttctggg atctgaaaga agaatttcat aaaatatgca tgctagcaaa agcacagaaa      480

gaccacttaa gcaaacttaa tataccagac actgcaactg aaacacagtg ctctgtgcct      540

atacagtgta cggataaaac agataaacaa gaagcgctgt ttaagcctca ggctaaagat      600

gatataaata gaggtgcacc atccatcaca tctgtcacac caagaggact gtgcagagat      660

gaggaagaca cctcttttga atcactttct aaattcaatg tcaagtttcc acctatggac      720

aatgactcaa ctttcttaca tagcactcca gagagacccg gcatccttag tcctgccacg      780

tctgaggcag tgtgccaaga gaaatttaat atggagttca gagacaaccc agggaacttt      840

gttaaaacag aagaaacttt atttgaaatt cagggaattg accccatagc ttcagctata      900

caaaacctta aaacaactga caaaacaaag ccctcaaatc tcgtaaacac ttgtatcagg      960

acaactctgg atagagctgc gtgtttgcca cctggagacc ataatgcatt atatgtaaat     1020

agcttcccac ttctggaccc atctgatgca ccttttccct cactcgattc cccgggaaaa     1080

gcaatccgag gaccacagca gcccatttgg aagccctttc ctaatcaaga cagtgactcg     1140

gtggtactaa gtggcacaga ctcagaactg catatacctc gagtatgtga attctgtcaa     1200

gcagttttcc caccatccat tacatccagg ggggatttcc ttcggcatct taattcacac     1260

ttcaatggag agacttaa                                                   1278


<210>  1117
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  1117
atggctgagc ttctcgccag cgcaggatca gcctgttcct gggactttcc gagagccccg       60

ccctcgttcc ctcccccagc cgccagtagg ggaggactcg gcggtacccg gagcttcagg      120

ccccaccggg gcgcggagag tcccaggccc ggccgggacc gggacggcgt ccgagtgcca      180

atggctagct ctaggtgtcc cgctccccgc gggtgccgct gcctccccgg agcttctctc      240

gcatggctgg ggacagtact gctacttctc gccgactggg tgctgctccg gaccgcgctg      300

ccccgcatat tctccctgct ggtgcccacc gcgctgccac tgctccgggt ctgggcggtg      360

ggcctgagcc gctgggccgt gctctggctg ggggcctgcg gggtcctcag ggcaacggtt      420

ggctccaaga gcgaaaacgc aggtgcccag ggctggctgg ctgctttgaa gccattagct      480

gcggcactgg gcttggccct gccgggactt gccttgttcc gagagctgat ctcatgggga      540

gcccccgggt ccgcggatag caccaggcta ctgcactggg gaagtcaccc taccgccttc      600

gttgtcagtt atgcagcggc actgcccgca gcagccctgt ggcacaaact cgggagcctc      660

tgggtgcccg gcggtcaggg cggctctgga aaccctgtgc gtcggcttct aggctgcctg      720

ggctcggaga cgcgccgcct ctcgctgttc ctggtcctgg tggtcctctc ctctcttggg      780

gagatggcca ttccattctt tacgggccgc ctcactgact ggattctaca agatggctca      840

gccgatacct tcactcgaaa cttaactctc atgtccattc tcaccatagc cagtgcagtg      900

ctggagttcg tgggtgacgg gatctataac aacaccatgg gccacgtgca cagccacttg      960

cagggagagg tgtttggggc tgtcctgcgc caggagacgg agtttttcca acagaaccag     1020

acaggtaaca tcatgtctcg ggtaacagag gacacgtcca ccctgagtga ttctctgagt     1080

gagaatctga gcttatttct gtggtacctg gtgcgaggcc tatgtctctt ggggatcatg     1140

ctctggggat cagtgtccct caccatggtc accctgatca ccctgcctct gcttttcctt     1200

ctgcccaaga aggtgggaaa atggtaccag ttgctggaag tgcaggtgcg ggaatctctg     1260

gcaaagtcca gccaggtggc cattgaggct ctgtcggcca tgcctacagt tcgaagcttt     1320

gccaacgagg agggcgaagc ccagaagttt agggaaaagc tgcaagaaat aaagacactc     1380

aaccagaagg aggctgtggc ctatgcagtc aactcctgga ccactagtat ttcaggtatg     1440

ctgctgaaag tgggaatcct ctacattggt gggcagctgg tgaccagtgg ggctgtaagc     1500

agtgggaacc ttgtcacatt tgttctctac cagatgcagt tcacccaggc tgtggaggta     1560

ctgctctcca tctaccccag agtacagaag gctgtgggct cctcagagaa aatatttgag     1620

tacctggacc gcacccctcg ctgcccaccc agtggtctgt tgactccctt acacttggag     1680

ggccttgtcc agttccaaga tgtctccttt gcctacccaa accgcccaga tgtcttagtg     1740

ctacaggggc tgacattcac cctacgccct ggcgaggtga cggcgctggt gggacccaat     1800

gggtctggga agagcacagt ggctgccctg ctgcagaatc tgtaccagcc caccggggga     1860

cagctgctgt tggatgggaa gccccttccc caatatgagc accgctacct gcacaggcag     1920

gtggctgcag tgggacaaga gccacaggta tttggaagaa gtcttcaaga aaatattgcc     1980

tatggcctga cccagaagcc aactatggag gaaatcacag ctgctgcagt aaagtctggg     2040

gcccatagtt tcatctctgg actccctcag ggctatgaca cagaggtaga cgaggctggg     2100

agccagctgt cagggggtca gcgacaggca gtggcgttgg cccgagcatt gatccggaaa     2160

ccgtgtgtac ttatcctgga tgatgccacc agtgccctgg atgcaaacag ccagttacag     2220

gtggagcagc tcctgtacga aagccctgag cggtactccc gctcagtgct tctcatcacc     2280

cagcacctca gcctggtgga gcaggctgac cacatcctct ttctggaagg aggcgctatc     2340

cgggaggggg gaacccacca gcagctcatg gagaaaaagg ggtgctactg ggccatggtg     2400

caggctcctg cagatgctcc agaatga                                         2427


<210>  1118
<211>  2004
<212>  DNA
<213>  Homo sapiens

<400>  1118
atgcatcacc aacagcgaat ggctgcctta gggacggaca aagagctgag tgatttactg       60

gatttcagtg cgatgttttc acctcctgtg agcagtggga aaaatggacc aacttctttg      120

gcaagtggac attttactgg ctcaaatgta gaagacagaa gtagctcagg gtcctggggg      180

aatggaggac atccaagccc gtccaggaac tatggagatg ggactcccta tgaccacatg      240

accagcaggg accttgggtc acatgacaat ctctctccac cttttgtcaa ttccagaata      300

caaagtaaaa cagaaagggg ctcatactca tcttatggga gagaatcaaa cttacagggt      360

tgccaccagc agagtctcct tggaggtgac atggatatgg gcaacccagg aaccctttcg      420

cccaccaaac ctggttccca gtactatcag tattctagca ataatccccg aaggaggcct      480

cttcacagta gtgccatgga ggtacagaca aagaaagttc gaaaagttcc tccaggtttg      540

ccatcttcag tctatgctcc atcagcaagc actgccgact acaataggga ctcgccaggc      600

tatccttcct ccaaaccagc aaccagcact ttccctagct ccttcttcat gcaagatggc      660

catcacagca gtgacccttg gagctcctcc agtgggatga atcagcctgg ctatgcagga      720

atgttgggca actcttctca tattccacag tccagcagct actgtagcct gcatccacat      780

gaacgtttga gctatccatc acactcctca gcagacatca attccagtct tcctccgatg      840

tccactttcc atcgtagtgg tacaaaccat tacagcacct cttcctgtac gcctcctgcc      900

aacgggacag acagtataat ggcaaataga ggaagcgggg cagccggcag ctcccagact      960

ggagatgctc tggggaaagc acttgcttcg atctattctc cagatcacac taacaacagc     1020

ttttcatcaa acccttcaac tcctgttggc tctcctccat ctctctcagc aggcacagct     1080

gtttggtcta gaaatggagg acaggcctca tcgtctccta attatgaagg acccttacac     1140

tctttgcaaa gccgaattga agatcgttta gaaagactgg atgatgctat tcatgttctc     1200

cggaaccatg cagtgggccc atccacagct atgcctggtg gtcatgggga catgcatgga     1260

atcattggac cttctcataa tggagccatg ggtggtctgg gctcagggta tggaaccggc     1320

cttctttcag ccaacagaca ttcactcatg gtggggaccc atcgtgaaga tggcgtggcc     1380

ctgagaggca gccattctct tctgccaaac caggttccgg ttccacagct tcctgtccag     1440

tctgcgactt cccctgacct gaacccaccc caggaccctt acagaggcat gccaccagga     1500

ctacaggggc agagtgtctc ctctggcagc tctgagatca aatccgatga cgagggtgat     1560

gagaacctgc aagacacgaa atcttcggag gacaagaaat tagatgacga caagaaggat     1620

atcaaatcaa ttactagcaa taatgacgat gaggacctga caccagagca gaaggcagag     1680

cgtgagaagg agcggaggat ggccaacaat gcccgagagc gtctgcgggt ccgtgacatc     1740

aacgaggctt tcaaagagct cggccgcatg gtgcagctcc acctcaagag tgacaagccc     1800

cagaccaagc tcctgatcct ccaccaggcg gtggccgtca tcctcagtct ggagcagcaa     1860

gtccgagaaa ggaatctgaa tccgaaagct gcgtgtctga aaagaaggga ggaagagaag     1920

gtgtcctcag agcctccccc tctctccttg gccggcccac accctggaat gggagacgca     1980

tcgaatcaca tgggacagat gtaa                                            2004


<210>  1119
<211>  2493
<212>  DNA
<213>  Homo sapiens

<400>  1119
atgggctcca tgttccggag cgaggaggtg gccctggtcc agctctttct gcccacagcg       60

gctgcctaca cctgcgtgag tcggctgggc gagctgggcc tcgtggagtt cagagacctc      120

aacgcctcgg tgagcgcctt ccagagacgc tttgtggttg atgttcggcg ctgtgaggag      180

ctggagaaga ccttcacctt cctgcaggag gaggtgcggc gggctgggct ggtcctgccc      240

ccgccaaagg ggaggctgcc ggcaccccca ccccgggacc tgctgcgcat ccaggaggag      300

acggagcgcc tggcccagga gctgcgggat gtgcggggca accagcaggc cctgcgggcc      360

cagctgcacc agctgcagct ccacgccgcc gtgctacgcc agggccatga acctcagctg      420

gcagccgccc acacagatgg ggcctcagag aggacgcccc tgctccaggc ccccgggggg      480

ccgcaccagg acctgagggt caactttgtg gcaggtgccg tggagcccca caaggcccct      540

gccctagagc gcctgctctg gagggcctgc cgcggcttcc tcattgccag cttcagggag      600

ctggagcagc cgctggagca ccccgtgacg ggcgagccag ccacgtggat gaccttcctc      660

atctcctact ggggtgagca gatcggacag aagatccgca agatcacgga ctgcttccac      720

tgccacgtct tcccgtttct gcagcaggag gaggcccgcc tcggggccct gcagcagctg      780

caacagcaga gccaggagct gcaggaggtc ctcggggaga cagagcggtt cctgagccag      840

gtgctaggcc gggtgctgca gctgctgccg ccagggcagg tgcaggtcca caagatgaag      900

gccgtgtacc tggccctgaa ccagtgcagc gtgagcacca cgcacaagtg cctcattgcc      960

gaggcctggt gctctgtgcg agacctgccc gccctgcagg aggccctgcg ggacagctcg     1020

atggaggagg gagtgagtgc cgtggctcac cgcatcccct gccgggacat gccccccaca     1080

ctcatccgca ccaaccgctt cacggccagc ttccagggca tcgtggatgc ctacggcgtg     1140

ggccgctacc aggaggtcaa ccccgctccc tacaccatca tcaccttccc cttcctgttt     1200

gctgtgatgt tcggggatgt gggccacggg ctgctcatgt tcctgttcgc cctggccatg     1260

gtccttgcgg agaaccgacc ggctgtgaag gccgcgcaga acgagatctg gcagactttc     1320

ttcaggggcc gctacctgct cctgcttatg ggcctgttct ccatctacac cggcttcatc     1380

tacaacgagt gcttcagtcg cgccaccagc atcttcccct cgggctggag tgtggccgcc     1440

atggccaacc agtctggctg gagtgatgca ttcctggccc agcacacgat gcttaccctg     1500

gatcccaacg tcaccggtgt cttcctggga ccctacccct ttggcatcga tcctatttgg     1560

agcctggctg ccaaccactt gagcttcctc aactccttca agatgaagat gtccgtcatc     1620

ctgggcgtcg tgcacatggc ctttggggtg gtcctcggag tcttcaacca cgtgcacttt     1680

ggccagaggc accggctgct gctggagacg ctgccggagc tcaccttcct gctgggactc     1740

ttcggttacc tcgtgttcct agtcatctac aagtggctgt gtgtctgggc tgccagggcc     1800

gcctcggccc ccagcatcct catccacttc atcaacatgt tcctcttctc ccacagcccc     1860

agcaacaggc tgctctaccc ccggcaggag gtggtccagg ccacgctggt ggtcctggcc     1920

ttggccatgg tgcccatcct gctgcttggc acacccctgc acctgctgca ccgccaccgc     1980

cgccgcctgc ggaggaggcc cgctgaccga caggaggaaa acaaggccgg gttgctggac     2040

ctgcctgacg catctgtgaa tggctggagc tccgatgagg aaaaggcagg gggcctggat     2100

gatgaagagg aggccgagct cgtcccctcc gaggtgctca tgcaccaggc catccacacc     2160

atcgagttct gcctgggctg cgtctccaac accgcctcct acctgcgcct gtgggccctg     2220

agcctggccc acgcccagct gtccgaggtt ctgtgggcca tggtgatgcg cataggcctg     2280

ggcctgggcc gggaggtggg cgtggcggct gtggtgctgg tccccatctt tgccgccttt     2340

gccgtgatga ccgtggctat cctgctggtg atggagggac tctcagcctt cctgcacgcc     2400

ctgcggctgc actgggtgga attccagaac aagttctact caggcacggg ctacaagctg     2460

agtcccttca ccttcgctgc cacagatgac tag                                  2493


<210>  1120
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  1120
atgggcgccg cggcccgcac cctgcggctg gcgctcggcc tcctgctgct ggcgacgctg       60

cttcgcccgg ccgacgcctg cagctgctcc ccggtgcacc cgcaacaggc gttttgcaat      120

gcagatgtag tgatcagggc caaagcggtc agtgagaagg aagtggactc tggaaacgac      180

atttatggca accctatcaa gaggatccag tatgagatca agcagataaa gatgttcaaa      240

gggcctgaga aggatataga gtttatctac acggccccct cctcggcagt gtgtggggtc      300

tcgctggacg ttggaggaaa gaaggaatat ctcattgcag gaaaggccga gggggacggc      360

aagatgcaca tcaccctctg tgacttcatc gtgccctggg acaccctgag caccacccag      420

aagaagagcc tgaaccacag gtaccagatg ggctgcgagt gcaagatcac gcgctgcccc      480

atgatcccgt gctacatctc ctccccggac gagtgcctct ggatggactg ggtcacagag      540

aagaacatca acgggcacca ggccaagttc ttcgcctgca tcaagagaag tgacggctcc      600

tgtgcgtggt accgcggcgc ggcgcccccc aagcaggagt ttctcgacat cgaggaccca      660

taa                                                                    663


<210>  1121
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  1121
atgggaaagt ctctttctca tttgcctttg cattcaagca aagaagatgc ttatgatgga       60

gtcacatctg aaaacatgag gaatggactg gttaatagtg aagtccataa tgaagatgga      120

agaaatggag atgtctctca gtttccatat gtggaattta caggaagaga tagtgtcacc      180

tgccctactt gtcagggaac aggaagaatt cctagggggc aagaaaacca actggtggca      240

ttgattccat atagtgatca gagattaagg ccaagaagaa caaagctgta tgtgatggct      300

tctgtgtttg tctgtctact cctttctgga ttggctgtgt ttttcctttt ccctcgctct      360

atcgacgtga aatacattgg tgtaaaatca gcctatgtca gttatgatgt tcagaagcgt      420

acaatttatt taaatatcac aaacacacta aatataacaa acaataacta ttactctgtc      480

gaagttgaaa acatcactgc ccaagttcaa ttttcaaaaa cagttattgg aaaggcacgc      540

ttaaacaaca taaccattat tggtccactt gatatgaaac aaattgatta cacagtacct      600

accgttatag cagaggaaat gagttatatg tatgatttct gtactctgat atccatcaaa      660

gtgcataaca tagtactcat gatgcaagtt actgtgacaa caacatactt tggccactct      720

gaacagatat cccaggagag gtatcagtat gtcgactgtg gaagaaacac aacttatcag      780

ttggggcagt ctgaatattt aaatgtactt cagccacaac agtaa                      825


<210>  1122
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  1122
atggcaggct tcctagataa ttttcgttgg ccagaatgtg aatgtattga ctggagtgag       60

agaagaaatg ctgtggcatc tgttgtcgca ggtatattgt tttttacagg ctggtggata      120

atgattgatg cagctgtggt gtatcctaag ccagaacagt tgaaccatgc ctttcacaca      180

tgtggtgtat tttccacatt ggctttcttc atgataaatg ctgtatccaa tgctcaggtg      240

agaggtgata gctatgaaag cggctgttta ggaagaacag gtgctcgagt ttggcttttc      300

attggtttca tgttgatgtt tgggtcactt attgcttcca tgtggattct ttttggtgca      360

tatgttaccc aaaatactga tgtttatccg ggactagctg tgttttttca aaatgcactt      420

atatttttta gcactctgat ctacaaattt ggaagaaccg aagagctatg gacctga         477


<210>  1123
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  1123
atggaaggga gaggaccgta ccggatctac gaccctgggg gcagcgtgcc ctcaggagag       60

gcatccgcag cttttgagcg cctagtgaag gagaattccc ggctgaagga aaaaatgcaa      120

gggataaaga tgttagggga gcttttggaa gagtcccaga tggaagcgac caggctccgg      180

cagaaggcag aggagctagt gaaggacaac gagctgctcc caccaccttc tccctccttg      240

ggctccttcg accccctggc tgagctcaca ggaaaggact caaatgtcac agcatctccc      300

acagcccctg catgccccag tgacaagcca gcaccagtcc agaagcctcc atccagtggc      360

acctcctctg aatttgaagt ggtcactcct gaggagcaga attcaccaga gagcagcagc      420

catgccaatg cgatggcgct gggccccctg ccccgtgagg acggcaacct gatgctgcac      480

ctgcagcgcc tggagaccac gctgagtgtg tgtgccgagg agccggacca cggccagctc      540

ttcacccacc tgggccgcat ggccctggag ttcaaccgac tggcatccaa ggtgcacaag      600

aatgagcagc gcacctccat tctgcagacc ctgtgtgagc agcttcggaa ggagaacgag      660

gctctgaagg ccaagttgga taagggcctg gaacagcggg atcaggctgc cgagaggctg      720

cgggaggaaa atttggagct caagaagttg ttgatgagca atggcaacaa agagggtgcg      780

tctgggcggc caggctcacc gaagatggaa gggacaggca agaaggcagt ggctggacag      840

cagcaggcta gtgtgacggc aggtaaggtc ccagaggtgg tggccttggg cgcagccgag      900

aagaaggtga agatgctgga gcagcagcgc agtgagctgc tggaagtgaa caagcagtgg      960

gaccagcatt tccggtccat gaagcagcag tatgagcaga agatcactga gctgcgtcag     1020

aagctggctg atttgcagaa gcaggtgact gacctggagg ccgagcggga gcagaagcag     1080

cgtgactttg accgcaagct cctcctggcc aagtccaaga ttgaaatgga ggagaccgac     1140

aaggagcagc tgacagcaga ggccaaggag ctgcgccaaa aggtcaagta cctgcaggat     1200

cagctgagcc cactcacccg acagcgtgag taccaggaaa aggagatcca gcggctcaac     1260

aaggccctgg aggaagcact gagcatccaa accccgccat catctccacc aacagcattt     1320

gggagcccag aaggagcagg ggccctccta aggaaacagg agctggtcac gcagaatgag     1380

ttgctgaaac agcaggtgaa gatcttcgag gaggacttcc agagggagcg cagtgatcgt     1440

gagcgcatga atgaggagaa ggaagagctg aagaagcaag tggagaagct gcaggcccag     1500

gtcaccctgt caaatgccca gctaaaagca ttcaaagatg aggagaaggc aagagaagcc     1560

ctcagacagc agaagaggaa agcaaaggcc tcaggagagc gttaccatgt ggagccccac     1620

ccagaacatc tctgcggggc ctacccctac gcctacccgc ccatgccagc catggtgcca     1680

caccatggct tcgaggactg gtcccagatc cgctaccccc ctccccccat ggccatggag     1740

cacccgcccc cactccccaa ctcgcgcctc ttccatctgc cggaatacac ctggcgtcta     1800

ccctgtggag gggttcgaaa tccaaatcag agctcccaag tgatggaccc tcccacagcc     1860

aggcctacag aaccagagtc tccaaaaaat gaccgtgagg ggcctcagtg a              1911


<210>  1124
<211>  4866
<212>  DNA
<213>  Homo sapiens

<400>  1124
atggccaagt cgggtggctg cggcgcggga gccggcgtgg gcggcggcaa cggggcactg       60

acctgggtga acaatgctgc aaaaaaagaa gagtcagaaa ctgccaacaa aaatgattct      120

tcaaagaagt tgtctgttga gagagtgtat cagaagaaga cacaacttga acacattctt      180

cttcgtcctg atacatatat tgggtcagtg gagccattga cgcagttcat gtgggtgtat      240

gatgaagatg taggaatgaa ttgcagggag gttacctttg tgccaggttt atacaagatc      300

tttgatgaaa ttttggttaa tgctgctgac aataaacaga gggataagaa catgacttgt      360

attaaagttt ctattgatcc tgaatctaac attataagca tttggaataa tgggaaaggc      420

attccagtag tagaacacaa ggtagagaaa gtttatgttc ctgctttaat ttttggacag      480

cttttaacat ccagtaacta tgatgatgat gagaaaaaag ttacaggtgg tcgtaatggt      540

tatggtgcaa aactttgtaa tattttcagt acaaagttta cagtagaaac agcttgcaaa      600

gaatacaaac acagttttaa gcagacatgg atgaataata tgatgaagac ttctgaagcc      660

aaaattaaac attttgatgg tgaagattac acatgcataa cattccaacc agatctgtcc      720

aaatttaaga tggaaaaact tgacaaggat attgtggccc tcatgactag aagggcatat      780

gatttggctg gttcgtgtag aggggtcaag gtcatgttta atggaaagaa attgcctgta      840

aatggatttc gcagttatgt agatctttat gtgaaagaca aattggatga aactggggtg      900

gccctgaaag ttattcatga gcttgcaaat gaaagatggg atgtttgtct cacattgagt      960

gaaaaaggat tccagcaaat cagctttgta aatagtattg caactacaaa aggtggacgg     1020

cacgtggatt atgtggtaga tcaagttgtt ggtaaactga ttgaagtagt taagaaaaag     1080

aacaaagctg gtgtatcagt gaaaccattt caagtaaaaa accatatatg ggtttttatt     1140

aattgcctta ttgaaaatcc aacttttgat tctcagacta aggaaaacat gactctgcag     1200

cccaaaagtt ttgggtctaa atgccagctg tcagaaaaat tttttaaagc agcctctaat     1260

tgtggcattg tagaaagtat cctgaactgg gtgaaattta aggctcagac tcagctgaat     1320

aagaagtgtt catcagtaaa atacagtaaa atcaaaggta ttcccaaact ggatgatgct     1380

aatgatgctg gtggtaaaca ttccctggag tgtacactga tattaacaga gggagactct     1440

gccaaatcac tggctgtgtc tggattaggt gtgattggac gagacagata cggagttttt     1500

ccactcaggg gcaaaattct taatgtacgg gaagcttctc ataaacagat catggaaaat     1560

gctgaaataa ataatattat taaaatagtt ggtctacaat ataagaaaag ttacgatgat     1620

gcagaatctc tgaaaacctt acgctatgga aagattatga ttatgaccga tcaggatcaa     1680

gatggttctc acataaaagg cctgcttatt aatttcatcc atcacaattg gccatcactt     1740

ttgaagcatg gttttcttga agagttcatt actcctattg taaaggcaag caaaaataag     1800

caggaacttt ccttctacag tattcctgaa tttgacgaat ggaaaaaaca tatagaaaac     1860

cagaaagcct ggaaaataaa gtactataaa ggattgggta ctagtacagc taaagaagca     1920

aaggaatatt ttgctgatat ggaaaggcat cgcatcttgt ttagatatgc tggtcctgaa     1980

gatgatgctg ccattacctt ggcatttagt aagaagaaga ttgatgacag aaaagaatgg     2040

ttaacaaatt ttatggaaga ccggagacag cgtaggctac atggcttacc agagcaattt     2100

ttatatggta ctgcaacaaa gcatttgact tataatgatt tcatcaacaa ggaattgatt     2160

ctcttctcaa actcagacaa tgaaagatct ataccatctc ttgttgatgg ctttaaacct     2220

ggccagcgga aagttttatt tacctgtttc aagaggaatg ataaacgtga agtaaaagtt     2280

gcccagttgg ctggctctgt tgctgagatg tcggcttatc atcatggaga acaagcattg     2340

atgatgacta ttgtgaattt ggctcagaac tttgtgggaa gtaacaacat taacttgctt     2400

cagcctattg gtcagtttgg aactcggctt catggtggca aagatgctgc aagccctcgt     2460

tatattttca caatgttaag cactttagca aggctacttt ttcctgctgt ggatgacaac     2520

ctccttaagt tcctttatga tgataatcaa cgtgtagagc ctgagtggta tattcctata     2580

attcccatgg ttttaataaa tggtgctgag ggcattggta ctggatgggc ttgtaaacta     2640

cccaactatg atgctaggga aattgtgaac aatgtcagac gaatgctaga tggcctggat     2700

cctcatccca tgcttccaaa ctacaaaaac tttaaaggca cgattcaaga acttggtcaa     2760

aaccagtatg cagtcagtgg tgaaatattt gtagtggaca gaaacacagt agaaattaca     2820

gagcttccag ttagaacttg gacacaggta tataaagaac aggttttaga acctatgcta     2880

aatggaacag ataaaacacc agcattaatt tctgattata aagaatatca tactgacaca     2940

actgtgaaat ttgtggtgaa aatgactgaa gagaaactag cacaagcaga agctgctgga     3000

ctgcataaag tttttaaact tcaaactact cttacttgta attccatggt actttttgat     3060

catatgggat gtctgaagaa atatgaaact gtgcaagaca ttctgaaaga attctttgat     3120

ttacgattaa gttattacgg tttacgtaag gagtggcttg tgggaatgtt gggagcagaa     3180

tctacaaagc ttaacaatca agcccgtttc attttagaga agatacaagg gaaaattact     3240

atagagaata ggtcaaagaa agatttgatt caaatgttag tccagagagg ttatgaatct     3300

gacccagtga aagcctggaa agaagcacaa gaaaaggcag cagaagagga tgaaacacaa     3360

aaccagcatg atgatagttc ctccgattca ggaactcctt caggcccaga ttttaattat     3420

attttaaata tgtctctgtg gtctcttact aaagaaaaag ttgaagaact gattaaacag     3480

agagatgcaa aagggcgaga ggtcaatgat cttaaaagaa aatctccttc agatctttgg     3540

aaagaggatt tagcggcatt tgttgaagaa ctggataaag tggaatctca agaacgagaa     3600

gatgttctgg ctggaatgtc tggaaaagca attaaaggta aagttggcaa acctaaggtg     3660

aagaaactcc agttggaaga gacaatgccc tcaccttatg gcagaagaat aattcctgaa     3720

attacagcta tgaaggcaga tgccagcaaa aagttgctga agaagaagaa gggtgatctt     3780

gatactgcag cagtaaaagt ggaatttgat gaagaattca gtggagcacc agtagaaggt     3840

gcaggagaag aggcattgac tccatcagtt cctataaata aaggtcccaa acctaagagg     3900

gagaagaagg agcctggtac cagagtgaga aaaacaccta catcatctgg taaacctagt     3960

gcaaagaaag tgaagaaacg gaatccttgg tcagatgatg aatccaagtc agaaagtgat     4020

ttggaagaaa cagaacctgt ggttattcca agagattctt tgcttaggag agcagcagcc     4080

gaaagaccta aatacacatt tgatttctca gaagaagagg atgatgatgc tgatgatgat     4140

gatgatgaca ataatgattt agaggaattg aaagttaaag catctcccat aacaaatgat     4200

ggggaagatg aatttgttcc ttcagatggg ttagataaag atgaatatac attttcacca     4260

ggcaaatcaa aagccactcc agaaaaatct ttgcatgaca aaaaaagtca ggattttgga     4320

aatctcttct catttccttc atattctcag aagtcagaag atgattcagc taaatttgac     4380

agtaatgaag aagattctgc ttctgttttt tcaccatcat ttggtctgaa acagacagat     4440

aaagttccaa gtaaaacggt agctgctaaa aagggaaaac cgtcttcaga tacagtccct     4500

aagcccaaga gagccccaaa acagaagaaa gtagtagagg ctgtaaactc tgactcggat     4560

tcagaatttg gcattccaaa gaagactaca acaccaaaag gtaaaggccg aggggcaaag     4620

aaaaggaaag catctggctc tgaaaatgaa ggcgattata accctggcag gaaaacatcc     4680

aaaacaacaa gcaagaaacc gaagaagaca tcttttgatc aggattcaga tgtggacatc     4740

ttcccctcag acttccctac tgagccacct tctctgccac gaaccggtcg ggctaggaaa     4800

gaagtaaaat attttgcaga gtctgatgaa gaagaagatg atgttgattt tgcaatgttt     4860

aattaa                                                                4866


<210>  1125
<211>  1692
<212>  DNA
<213>  Homo sapiens

<400>  1125
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccct ga                                                         1692


<210>  1126
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  1126
atgatcagcc cagaccccag gccctcccct ggcttggccc ggtgggctga gagctatgag       60

gccaagtgtg agcgcaggca agagatccgt gaaagccgcc gctgccgtcc caatgtgacc      120

acttgccgcc aggtggggaa gacgctgagg atccaacaga gagagcagct ccagagagct      180

cgactgcagc agttcttcag gaggaggaac ctggagctag aggagaaggg caaagcgcag      240

catccccagg ccagggagca agggccctcc aggcggccag gacaggtgac tgtcctcaag      300

gaacccttgt cttgtgccag aaggatttct tctcccagag agcaggtgac aggcaccagc      360

tctgaagtct ttccagccca gcatcctcct ccctcaggca tctgcaggga tctgtctgac      420

cacctctcct cacaggctgg gggccttcct ccacaggaca ctcccatcaa gaagccaccc      480

aaacaccacc gtggtactca gacaaaggca gaaggaccaa caattaagaa cgatgccagt      540

cagcaaacca attacggagt tgcagttctg gataaggaaa tcatccagct ttctgattac      600

ctcaaagagg ccctacaaag ggagctggtc ctaaaacaga aaatggtgat tctccaagac      660

ctactgtcca ctctgattca ggcctctgac agctcttgga agggacagct taatgaagac      720

aaactgaagg ggaaactgag atccttagaa aaccagctat acacctgtac ccagaaatac      780

tccccttggg gaatgaaaaa agtactactg gagatggaag accagaaaaa cagctatgag      840

cagaaggcca aggagtcact gcagaaagtg ctggaggaga aaatgaatgc agagcagcaa      900

ctacagagca cacagcgatc cctggccctg gcagagcaga agtgtgaaga gtggaggagc      960

cagtatgagg ctctgaagga ggactggagg acccttggga cccagcacag ggagctggag     1020

agccaactcc acgtgcttca gtccaaactg cagggagcag atagcaggga cttacagatg     1080

aaccaggccc tgcgattttt ggaaaatgag caccagcaac tgcaggccaa gattgaatgc     1140

ctgcaagggg acagagacct gtgcagcttg gatacccagg acctacaaga tcaactaaaa     1200

aggtcagagg cagagaaact caccctggtg accagagtac agcagttgca gggtttgctt     1260

caaaatcaat ccttacagct tcaagaacag gagaaactct taacaaagaa agatcaggct     1320

ttgcccgtgt ggagtccaaa gtccttccct aacgaagtgg agcctgaggg tacagggaag     1380

gagaaagact gggatctcag agaccagctg caaaagaaga ctttgcagct ccaggccaag     1440

gaaaaggagt gcagagaact gcattcagaa ttagacaacc tcagtgacga gtatctctcc     1500

tgcctgcgta agctgcagca ctgtcgagaa gagctgaacc agagccagca gctgcctccc     1560

agaaggcaat gtgggcgatg gctcccagtg ctgatggtgg tgattgctgc agcactggca     1620

gtgttcctgg ccaataaaga caacctgatg atctga                               1656


<210>  1127
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  1127
atgcgggtcg gtccggtgcg ctctgccatg agcggcgcct cgcagccccg cggcccggcc       60

ctgctcttcc cagccacccg aggcgtcccg gccaaacgcc tgctggacgc cgacgacgcg      120

gcggctgtgg cggccaagtg cccgcgcctc tccgagtgct ccagcccccc ggactacctc      180

agcccccccg gctcgccctg cagcccgcag cccccgcctg ccgctccggg ggccggcgga      240

ggctccggga gcgcgccggg gcccagccgc atcgccgact acctgctgct gcccctagcc      300

gagcgcgagc atgtgtcccg ggcgctgtgc atccacactg gacgcgagct gcgctgcaag      360

gtgtttccca ttaaacacta ccaggacaaa atcaggcctt acatccagct gccatcgcac      420

agcaacatta ctggcattgt ggaagtgatc cttggggaaa ccaaggccta tgtcttcttt      480

gagaaggact ttggggacat gcactcctat gtgcgaagcc ggaagaggct gcgggaagag      540

gaagccgccc ggctcttcaa gcagattgtc tccgccgtcg cccactgcca ccagtcagcc      600

atcgtgctgg gggacctgaa gcttaggaag ttcgtcttct ccacggagga gagaacccag      660

cttagactag aaagtctaga agacacacac ataatgaagg gggaagatga tgctttgtca      720

gacaaacatg gctgcccagc ctacgtgagc cctgagatcc tcaacaccac tgggacctac      780

tccggaaagg ctgcggacgt ttggagcctg ggggtgatgc tctacaccct tctggttgga      840

cgatacccct tccatgactc agaccccagt gcccttttct ccaaaattcg gcgtggacag      900

ttctgcattc ctgagcacat ttcccccaaa gccaggtgcc tcattcgcag cctcttgaga      960

cgggagccct ccgagagact cactgccccc gagatcctac tgcacccctg gtttgagtcc     1020

gtcttggaac ccgggtacat cgactcagaa ataggaactt cagaccagat tgttccagag     1080

taccaggagg acagtgacat tagttccttc ttctgctaa                            1119


<210>  1128
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  1128
atggcgtccg tggcggctgc acgagcagtt cccgtgggca gtgggctcag gggcctgcaa       60

cggaccctac ctcttgtagt gattctcggg gccacgggca ccggcaaatc cacgctggcg      120

ttgcagctag gccagcggct cggcggtgag atcgtcagcg ctgactccat gcaggtctat      180

gaaggcctag acatcatcac caacaaggtt tctgcccaag agcagagaat ctgccggcac      240

cacatgatca gctttgtgga tcctcttgtg accaattaca cagtggtgga cttcagaaat      300

agagcaactg ctctgattga agatatattt gcccgagaca aaattcctat tgttgtggga      360

ggaaccaatt attacattga atctctgctc tggaaagttc ttgtcaatac caagccccag      420

gagatgggca ctgagaaagt gattgaccga aaagtggagc ttgaaaagga ggatggtctt      480

gtacttcaca aacgcctaag ccaggtggac ccagaaatgg ctgccaagct gcatccacat      540

gacaaacgca aagtggccag gagcttgcaa gtttttgaag aaacaggaat ctctcatagt      600

gaatttctcc atcgtcaaca tacggaagaa ggtggtggtc cccttggagg tcctctgaag      660

ttctctaacc cttgcatcct ttggcttcat gctgaccagg cagttctaga tgagcgcttg      720

gataagaggg tggatgacat gcttgctgct gggctcttgg aggaactaag agattttcac      780

agacgctata atcagaagaa tgtttcggaa aatagccagg actatcaaca tggtatcttc      840

caatcaattg gcttcaagga atttcacgag tacctgatca ctgagggaaa atgcacactg      900

gagactagta accagcttct aaagaaaggt attgaggctc tgaaacaagt aactaagaga      960

tatgcccgga aacaaaaccg atgggttaaa aaccgttttt tgagcagacc tggtcccatt     1020

gtcccccctg tctatggctt agaggtatct gatgtctcga agtgggaaga gtctgttctt     1080

gaacctgctc ttgaaatcgt gcaaagtttc atccagggcc acaagcctac agccactcca     1140

ataaagatgc catacaatga agctgagaac aagagaagtt atcacctgtg tgacctctgt     1200

gatcgaatca tcattgggga tcgcgaatgg gcagcgcaca taaaatccaa atcccacttg     1260

aaccaactga agaaaagaag aagattggac tcagatgctg tcaacaccat agaaagtcag     1320

agtgtttccc cagaccataa caaagaacct aaagagaagg gatccccagg gcagaatgat     1380

caagagctga aatgcagcgt ttaa                                            1404


<210>  1129
<211>  1617
<212>  DNA
<213>  Homo sapiens

<400>  1129
atggaggaat ctgtaaacca aatgcagcca ctgaatgaga agcagatagc caattctcag       60

gatggatatg tatggcaagt cactgacatg aatcgactac accggttctt atgtttcggt      120

tctgaaggtg ggacttatta tatcaaagaa cagaagttgg gccttgaaaa tgctgaagct      180

ttaattagat tgattgaaga tggcagagga tgtgaagtga tacaagaaat aaagtcattt      240

agtcaagaag gcagaaccac aaagcaagag cctatgctct ttgcacttgc catttgttcc      300

cagtgctccg acataagcac aaaacaagca gcatttaaag ctgtttctga agtttgtcgc      360

attcctaccc atctctttac ttttatccag tttaagaaag atctgaagga aagcatgaaa      420

tgtggcatgt ggggtcgtgc cctccggaag gctatagcgg actggtacaa tgagaaaggt      480

ggcatggccc ttgctctggc agttacaaaa tataaacaga gaaatggctg gtctcacaaa      540

gatctattaa gattgtcaca tcttaaacct tccagtgaag gacttgcaat tgtgaccaaa      600

tatattacaa agggctggaa agaagttcat gaattgtata aagaaaaagc actctctgtg      660

gagactgaaa aattattaaa gtatctggag gctgtagaga aagtgaagcg cacaagagat      720

gagctagaag tcattcatct aatagaagaa catagattag ttagagaaca tcttttaaca      780

aatcacttaa agtctaaaga ggtatggaag gctttgttac aagaaatgcc gcttactgca      840

ttactaagga atctaggaaa gatgactgct aattcagtac ttgaaccagg aaattcagaa      900

gtatctttag tatgtgaaaa actgtgtaat gaaaaactat taaaaaaggc tcgtatacat      960

ccatttcata ttttgatcgc attagaaact tacaagacag gtcatggtct cagagggaaa     1020

ctgaagtggc gccctgatga agaaattttg aaagcattgg atgctgcttt ttataaaaca     1080

tttaagacag ttgaaccaac tggaaaacgt ttcttactag ctgttgatgt cagtgcttct     1140

atgaaccaaa gagttttggg tagtatactc aacgctagta cagttgctgc agcaatgtgc     1200

atggttgtca cacgaacaga aaaagattct tatgtagttg ctttttccga tgaaatggta     1260

ccatgtccag tgactacaga tatgacctta caacaggttt taatggctat gagtcagatc     1320

ccagcaggtg gaactgattg ctctcttcca atgatctggg ctcagaagac aaacacacct     1380

gctgatgtct tcattgtatt cactgataat gagacctttg ctggaggtgt ccatcctgct     1440

attgctctga gggagtatcg aaagaaaatg gatattccag ctaaattgat tgtttgtgga     1500

atgacatcaa atggtttcac cattgcagac ccagatgata gaggcatgtt ggatatgtgc     1560

ggctttgata ctggagctct ggatgtaatt cgaaatttca cattagatat gatttaa        1617


<210>  1130
<211>  2394
<212>  DNA
<213>  Homo sapiens

<400>  1130
atggcggcgg cgccggtagc ggctgggtct ggagccggcc gagggagacg gtcggcagcc       60

acagtggcgg cttggggcgg atggggcggc cggccgcggc ctggtaacat tctgctgcag      120

ctgcggcagg gccagctgac cggccggggc ctggtccggg cggtgcagtt cactgagact      180

tttttgacgg agagggacaa acaatccaag tggagtggaa ttcctcagct gctcctcaag      240

ctgcacacca ccagccacct ccacagtgac tttgttgagt gtcaaaacat cctcaaggaa      300

atttctcctc ttctctccat ggaggctatg gcatttgtta ctgaagagag gaaacttacc      360

caagaaacca cttatccaaa tacttacatt tttgacttgt ttggaggtgt tgatcttctt      420

gtagaaattc ttatgaggcc tacgatctct atccggggac agaaactgaa aataagtgat      480

gaaatgtcca aggactgctt gagtatcctg tataatacct gtgtctgtac agagggagtt      540

acaaagcgtt tggcagaaaa gaatgacttt gtgatcttcc tgtttacatt gatgacaagt      600

aagaagacat tcttacaaac agcaaccctc attgaagata ttttgggtgt taaaaaggaa      660

atgatccgac tagatgaagt ccccaatctg agttccttag tatccaattt cgatcagcag      720

cagctcgcta atttctgccg gattctggct gtcaccattt cagagatgga tacagggaat      780

gatgacaagc acacgcttct tgccaaaaat gctcaacaga agaagagctt gagtttgggg      840

ccttctgcag ctgaaatcaa tcaagcggcc cttctcagca ttcctggctt tgttgagcgg      900

ctttgcaaac tggcgactcg aaaggtgtca gagtcaacgg gcacagccag cttccttcag      960

gagttggaag agtggtacac atggctagac aatgctttgg tgctagatgc cctgatgcga     1020

gtggccaatg aggagtcaga gcacaatcaa gcctccattg tgttccctcc tccaggggct     1080

tctgaggaga atggcctgcc tcacacgtca gccagaaccc agctgcccca gtcaatgaag     1140

attatgcatg agatcatgta caaactggaa gtgctctatg tcctctgcgt gctgctgatg     1200

gggcgtcagc gaaaccaggt tcacagaatg attgcagagt tcaagctgat ccctggactt     1260

aataatttgt ttgacaaact gatttggagg aagcattcag catctgccct tgtcctccat     1320

ggtcacaacc agaactgtga ctgtagcccg gacatcacct tgaagataca gtttttgagg     1380

cttcttcaga gcttcagtga ccaccacgag aacaagtact tgttactcaa caaccaggag     1440

ctgaatgaac tcagtgccat ctctctcaag gccaacatcc ctgaggtgga agctgtcctc     1500

aacaccgaca ggagtttggt gtgtgatggg aagaggggct tattaactcg tctgctgcag     1560

gtcatgaaga aggagccagc agagtcgtct ttcaggtttt ggcaagctcg ggctgtggag     1620

agtttcctcc gagggaccac ctcctatgca gaccagatgt tcctgctgaa gcgaggcctc     1680

ttggagcaca tcctttactg cattgtggac agcgagtgta agtcaaggga tgtgctccag     1740

agttactttg acctcctggg ggagctgatg aagttcaacg ttgatgcatt caagagattc     1800

aataaatata tcaacaccga tgcaaagttc caggtattcc tgaagcagat caacagctcc     1860

ctggtggact ccaacatgct ggtgcgctgt gtcactctgt ccctggaccg atttgaaaac     1920

caggtggata tgaaagttgc cgaggtactg tctgaatgcc gcctgctcgc ctacatatcc     1980

caggtgccca cgcagatgtc cttcctcttc cgcctcatca acatcatcca cgtgcagacg     2040

ctgacccagg agaacgtcag ctgcctcaac accagcctgg tgatcctgat gctggcccga     2100

cggaaagagc ggctgcccct gtacctgcgg ctgctgcagc ggatggagca cagcaagaag     2160

taccccggct tcctgctcaa caacttccac aacctgctgc gcttctggca gcagcactac     2220

ctgcacaagg acaaggacag cacctgccta gagaacagct cctgcatcag cttctcatac     2280

tggaaggaga cagtgtccat cctgttgaac ccggaccggc agtcaccctc tgctctcgtt     2340

agctacattg aggagcccta catggacata gacagggact tcactgagga gtga           2394


<210>  1131
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  1131
atggccccgc cctgggtgcc cgccatgggc ttcacgctgg cgcccagcct ggggtgcttc       60

gtgggctccc gctttgtcca cggcgagggt ctccgctggt acgccggcct gcagaagccc      120

tcgtggcacc cgccccactg ggtgctgggc cctgtctggg gcacgctcta ctcagccatg      180

gggtacggct cctacctggt ctggaaagag ctgggaggct tcacagagaa ggctgtggtt      240

cccctgggcc tctacactgg gcagctggcc ctgaactggg catggccccc catcttcttt      300

ggtgcccgac aaatgggctg ggccttggtg gatctcctgc tggtcagtgg ggcggcggca      360

gccactaccg tggcctggta ccaggtgagc ccgctggccg cccgcctgct ctacccctac      420

ctggcctggc tggccttcac gaccacactc aactactgcg tatggcggga caaccatggc      480

tggcgtgggg gacggcggct gccagagtga                                       510


<210>  1132
<211>  3426
<212>  DNA
<213>  Homo sapiens

<400>  1132
atggcggcgg cagtaggggt tcgtggccgg tacgagctgc cgccttgctc cggcccaggc       60

tggctcctca gcctttccgc cttgctgagt gtggcggcac gaggggcctt cgccaccacg      120

cactgggtcg tcacggagga cgggaaaatc cagcagcagg tggattcacc aatgaacttg      180

aagcatcctc atgacctagt catattaatg agacaagaag caacagttaa ctacctcaaa      240

gaattagaga aacaattagt tgctcaaaaa attcacatag aagagaatga ggacagagac      300

acaggactgg aacagagaca taataaagaa gacccagact gcatcaaagc caaggtgccc      360

ttaggggacc tggatctata tgatggcaca tacataactt tggagagcaa agacatcagt      420

cctgaagatt atatagacac agaatctcct gtccctccag acccagagca acctgattgt      480

actaaaattc tagaacttcc atatagtata catgcttttc agcacttgag aggtgtacag      540

gagagagtta atctttctgc acctctgcta cctaaagaag acccaatctt cacatattta      600

tctaaacggt taggaaggag tatagatgac ataggtcacc tcattcatga aggcctacag      660

aagaacactt cctcgtgggt actgtataac atggcttcat tttactggag aattaagaat      720

gagccatatc aggtagtaga atgtgccatg cgagcacttc acttctcttc caggcacaat      780

aaagacattg ccctggtcaa cctggcaaac gttctacaca gagcacactt ctctgctgat      840

gctgctgtcg tggtccatgc agctctggat gacagtgact tcttcaccag ctattacact      900

ttggggaata tatatgcaat gcttggggaa tataaccact cagtgctctg ttatgaccac      960

gctttgcagg ccagacctgg gtttgagcaa gctataaaga ggaagcatgc tgtcctatgt     1020

cagcaaaaac tggagcagaa attggaggct cagcatagat ctctccagcg aacactgaat     1080

gagttaaaag agtatcaaaa gcagcatgac cactacctga gacagcagga aatcctagaa     1140

aaacataaac tgattcagga ggagcaaatc ttaagaaata tcattcatga gactcagatg     1200

gcaaaagagg cacaattagg aaatcatcag atatgccgac tggtcaacca gcagcatagt     1260

ttacattgcc agtgggacca gcctgtacgc tatcatcgtg gagatatctt tgaaaatgtg     1320

gactatgttc agtttggtga ggattcatca acctccagta tgatgtctgt gaactttgat     1380

gttcaatcaa atcagagtga tatcaatgat tcggtcaagt cttctcccgt agcccattct     1440

attctctgga tttggggcag ggactctgat gcatataggg acaaacagca tattctatgg     1500

cctaaaagag cagattgtac agaaagctac cctagagtcc ctgttggtgg ggaattgcca     1560

acgtattttc tgcctccgga aaacaaagga ctcaggatcc acgaactcag cagtgatgat     1620

tattctacag aagaagaggc ccaaacccct gactgttcca taactgactt cagaaaaagc     1680

cacactctgt cctacttagt caaagaatta gaggttcgca tggatctgaa agccaaaatg     1740

ccagatgacc atgcacgaaa aattttgctt tcccgtatta ataactatac tatcccagaa     1800

gaagaaattg ggtctttctt atttcatgct attaataagc caaatgctcc tatctggctc     1860

atactcaatg aagctggact atactggaga gcagtaggaa atagcacttt tgctattgcc     1920

tgtcttcaga gggctttgaa tttagctcca cttcaatacc aagatgttcc tcttgtcaac     1980

ttggccaacc ttttgattca ttacggcctt catcttgatg ccactaagct gctacttcaa     2040

gctttggcca tcaatagctc tgagcctctg acctttttga gcctgggaaa tgcttacctt     2100

gctctgaaga atatcagtgg ggcacttgag gcctttagac aggccttgaa attaaccacc     2160

aaatgtccag agtgtgaaaa cagcctgaag ttgatccgct gtatgcagtt ttatcctttt     2220

ctgtacaaca tcacttcttc tgtttgcagt ggtacggtgg ttgaggagag caatggttct     2280

gatgagatgg agaattcaga tgaaaccaaa atgtcagaag aaatactggc tttggtggat     2340

gaatttcaac aggcatggcc tttggaaggc tttgggggtg cactagagat gaaagggcgg     2400

cgtctagact tacaaggaat acgggtgctg aagaaaggtc cccaggatgg agtggccaga     2460

agctcttgct atggagactg cagaagtgaa gatgatgaag caacagaatg gattacattc     2520

caggtcaaac gtgtaaagaa acccaaagga gatcataaga aaactcctgg gaaaaaagta     2580

gaaacaggtc agatagaaaa tggacatcgt taccaagcaa acctagagat cactggcccc     2640

aaggtggcat ctcctgggcc acaaggaaaa aaacgtgact accagcgtct gggatggccc     2700

agcccggacg aatgcctcaa actccgctgg gtagagctga ctgccatcgt gagtacctgg     2760

cttgcagttt cttcaaaaaa cattgacatc acagaacaca tagattttgc cacccctata     2820

cagcagccag caatggagcc tctttgcaat ggcaatctcc ccacgagtat gcataccctg     2880

gaccacttgc atggggtttc caaccgagcc agcctgcact acacagggga gagtcagtta     2940

acagaggtat tacaaaatct cggcaaagac caatatccac aacagtcgct tgaacagatt     3000

ggcacccgaa ttgccaaagt tttggaaaag aaccagacgt cctgggtcct ctccagcatg     3060

gcagccctct actggagggt gaaaggccaa ggaaagaagg caatcgactg cctccgccag     3120

gctctgcact atgcgccaca ccagatgaag gatgtgcccc tgattagcct ggccaacatc     3180

ttgcacaatg ccaagctctg gaatgacgcc gtcatagtag ccaccatggc agtagagatc     3240

gcaccacact ttgctgtgaa ccacttcact ctgggcaatg tctacgtggc aatggaagaa     3300

tttgaaaaag cactggtgtg gtatgaatcc acattgaagc ttcagcccga gtttgtccca     3360

gccaagaacc gaatccagac catccagtgt cacttaatgc tgaagaaggg acggcgctct     3420

ccttag                                                                3426


<210>  1133
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  1133
atgcgtgagt gcatctccat ccacgttggc caggctggtg tccagattgg caatgcctgc       60

tgggagctct actgcctgga acacggcatc cagcccgatg gccagatgcc aagtgacaag      120

accattgggg gaggagatga ctccttcaac accttcttca gtgagacggg cgctggcaag      180

cacgtgcccc gggctgtgtt tgtagacttg gaacccacag tcattgatga agttcgcact      240

ggcacctacc gccagctctt ccaccctgag cagctcatca caggcaagga agatgctgcc      300

aataactatg cccgagggca ctacaccatt ggcaaggaga tcattgacct tgtgttggac      360

cgaattcgca agctggctga ccagtgcacc ggtcttcagg gcttcttggt tttccacagc      420

tttggtgggg gaactggttc tgggttcacc tccctgctca tggaacgtct ctcagttgat      480

tatggcaaga agtccaagct ggagttctcc atttacccag caccccaggt ttccacagct      540

gtagttgagc cctacaactc catcctcacc acccacacca ccctggagca ctctgattgt      600

gccttcatgg tagacaatga ggccatctat gacatctgtc gtagaaacct cgatatcgag      660

cgcccaacct acactaacct taaccgcctt attagccaga ttgtgtcctc catcactgct      720

tccctgagat ttgatggagc cctgaatgtt gacctgacag aattccagac caacctggtg      780

ccctaccccc gcatccactt ccctctggcc acatatgccc ctgtcatctc tgctgagaaa      840

gcctaccatg aacagctttc tgtagcagag atcaccaatg cttgctttga gccagccaac      900

cagatggtga aatgtgaccc tcgccatggt aaatacatgg cttgctgcct gttgtaccgt      960

ggtgacgtgg ttcccaaaga tgtcaatgct gccattgcca ccatcaaaac caagcgcagc     1020

atccagtttg tggattggtg ccccactggc ttcaaggttg gcatcaacta ccagcctccc     1080

actgtggtgc ctggtggaga cctggccaag gtacagagag ctgtgtgcat gctgagcaac     1140

accacagcca ttgctgaggc ctgggctcgc ctggaccaca agtttgacct gatgtatgcc     1200

aagcgtgcct ttgttcactg gtacgtgggt gaggggatgg aggaaggcga gttttcagag     1260

gcccgtgaag atatggctgc ccttgagaag gattatgagg aggttggtgt ggattctgtt     1320

gaaggagagg gtgaggaaga aggagaggaa tactaa                               1356


<210>  1134
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  1134
atgatggcga gcatgcgagt ggtgaaggag ctggaggatc ttcagaagaa gcctccccca       60

tacctgcgga acctgtccag cgatgatgcc aatgtcctgg tgtggcacgc tctcctccta      120

cccgaccaac ctccctacca cctgaaagcc ttcaacctgc gcatcagctt cccgccggag      180

tatccgttca agcctcccat gatcaaattc acaaccaaga tctaccaccc caacgtggac      240

gagaacggac agatttgcct gcccatcatc agcagtgaga actggaagcc ttgcaccaag      300

acttgccaag tcctggaggc cctcaatgtg ctggtgaata gaccgaatat cagggagccc      360

ctgcggatgg acctcgctga cctgctgaca cagaatccgg agctgttcag aaagaatgcc      420

gaagagttca ccctccgatt cggagtggac cggccctcct aa                         462


<210>  1135
<211>  258
<212>  DNA
<213>  Homo sapiens

<400>  1135
atgtcgaagg tttcctttaa gatcacgctg acgtcggacc cacggctgcc gtacaaagta       60

ctcagtgttc ctgaaagtac acctttcaca gcagtcttaa agtttgcagc agaagaattt      120

aaagttcctg ctgcaacaag tgcaattatt accaatgatg gaataggaat aaatcctgca      180

cagactgctg gaaatgtttt tctaaaacat ggttcagaac tgcggattat tcctagagat      240

cgtgttggaa gttgttaa                                                    258


<210>  1136
<211>  933
<212>  DNA
<213>  Homo sapiens

<400>  1136
atggcggcca cgggagccaa tgcagagaaa gctgaaagtc acaatgattg ccccgtcaga       60

cttttaaatc caaacatagc aaaaatgaaa gaagatattc tctatcattt caatctcacc      120

actagcagac acaatttccc agccttgttt ggagatgtga agtttgtgtg tgttggtgga      180

agcccctccc ggatgaaagc cttcatcagg tgcgttggtg cagagctggg ccttgactgc      240

ccaggtagag actatcccaa catctgtgcg ggaactgacc gctatgccat gtataaagta      300

ggaccggtgc tgtctgtcag tcatggtatg ggcattcctt ctatctcaat catgttgcat      360

gagctcataa agctgctgta ctatgcccgg tgctccaacg tcactatcat ccgcattggc      420

acttctggtg ggataggtct ggagcccggc actgtggtca taacagagca ggcagtggat      480

acctgcttca aggcagagtt tgagcagatt gtcctgggga agcgggtcat ccggaaaacg      540

gaccttaaca agaagctggt gcaggagctg ttgctgtgtt ctgcagagct gagcgagttc      600

accacagtgg tggggaacac catgtgcacc ttggacttct atgaagggca aggccgtctg      660

gatggggctc tctgctccta cacggagaag gacaagcagg cgtatctgga ggcagcctat      720

gcagccggcg tccgcaatat cgagatggag tcctcggtgt ttgccgccat gtgcagcgcc      780

tgcggcctcc aagcggccgt ggtgtgtgtc accctcctga accgcctgga aggggaccag      840

atcagcagcc ctcgcaatgt gctcagcgag taccagcaga ggccgcagcg gctggtgagc      900

tacttcatca agaagaaact gagcaaggcc tga                                   933


<210>  1137
<211>  10641
<212>  DNA
<213>  Homo sapiens

<400>  1137
atgtgcgaga actgcgcaga cctggtggag gtgttaaatg aaatatcaga tgtagaaggt       60

ggtgatggac tgcagctcag aaaggaacat actctcaaaa tatttactta tatcaattcc      120

tggacacaga ggcaatgtct atgctgcttc aaggaatata agcatttgga gatttttaat      180

caagtagtgt gtgcacttat taacttagtg attgcccaag ttcaagtgct ccgggaccag      240

ctttgtaaac attgtactac cattaacata gattccacgt ggcaagatga gagtaatcaa      300

gcagaagaac cactgaatat agatagagag tgtaatgaag gaagtacaga aagacaaaaa      360

tcaatagaaa aaaaatcaaa ctctacaaga atttgtaatc tgactgagga ggaatcttca      420

aagagttctg atccttttag tttatggagt acagatgaga aggaaaaact cttactatgt      480

gtggcaaaaa tttttcaaat tcagtttccc ttatatactg cttacaagca taatactcac      540

cctactattg aggatatatc aactcaagaa agtaacatat taggggcatt ctgtgatatg      600

aatgatgtag aagtaccatt gcatttgctt cgttatgtat gtttgttttg tgggaaaaat      660

ggcctttctc tcatgaagga ttgctttgaa tatggaactc ctgaaacttt gccatttctt      720

atagcacatg cgtttattac agttgtgtct aatattagaa tatggctaca tattcccgct      780

gtcatgcagc acattatacc ttttaggacc tatgttatta ggtatttatg caagctctcg      840

gatcaggagt tacgacagag tgcagctcgt aacatggctg acttaatgtg gagcacagtc      900

aaagaaccat tggatacaac attatgcttt gataaagaaa gcctagatct tgcatttaag      960

tactttatgt cacctacttt gactatgagg ttggctggat tgagtcagat aacaaatcaa     1020

ctccatacct tcaatgatgt gtgcaataat gaatcattag tatcggacac agaaacgtcc     1080

attgcaaaag aacttgcaga ctggcttatt agcaacaatg tggtggagca tatatttgga     1140

ccaaatttac atattgagat tatcaaacag tgccaagtga ttttgaattt tttggcagca     1200

gaagggcgac tgagtactca acatattgac tgtatttggg ctgcagcaca gttgaaacat     1260

tgtagtcggt atatacatga cttatttcct tcactcatca agaatttgga tcccgtacca     1320

cttagacatc tacttaatct ggtctcagct cttgagccaa gtgttcatac tgaacagaca     1380

ctgtacttgg catccatgtt aattaaagca ctgtggaata acgcactagc agctaaggct     1440

cagttatcta aacagagttc ttttgcatct ttattaaata ctaatattcc cattggaaat     1500

aagaaagagg aagaagagct tagaagaaca gctccatcac cttggtcacc tgcagctagt     1560

cctcaaagca gtgataatag cgatacacat caaagtggag gtagtgacat tgaaatggat     1620

gagcaactta ttaatagaac caaacatgtg caacaacgac tttcagacac agaggaatcc     1680

atgcagggaa gttctgacga aactgccaac agtggtgaag atggaagcag tggtcctggt     1740

agcagtagtg ggcatagtga tggatctagc aatgaggtta attctagcca cgcaagccag     1800

tcagctggga gccctggcag tgaggtacag tcagaagaca ttgcagatat tgaagccctc     1860

aaagaggaag atgaagacga tgatcatggt cataatcctc ccaaaagcag ttgtggtaca     1920

gatcttcgga atagaaagtt agagagtcaa gcaggcattt gcctggggga ctcccaaggc     1980

atgtcagaaa gaaatgggac aagcagcgga acaggaaagg acctggtttt taacactgaa     2040

tcattgccat cagtagataa tcgaatgcga atgctggatg cttgttcaca ctctgaagac     2100

ccagaacatg atatttcagg ggaaatgaat gctactcata tagcacaagg gtctcaggag     2160

tcttgtatca cacgaactgg ggacttcctt ggggagacta ttgggaatga attatttaat     2220

tgtcgacaat ttattggtcc acagcatcac caccaccacc accaccatca ccaccaccac     2280

gatgggcata tggttgatga tatgctaagt gcagatgatg tcagttgtag tagctcccag     2340

gttagtgcaa aatcagaaaa aaatatggct gattttgatg gtgaagaatc tggatgtgaa     2400

gaggagctag ttcagattaa ttcacatgcg gaactgacat ctcacctcca acaacatctt     2460

cccaatttag cttccattta ccatgaacat cttagtcaag gacctgtagt tcataaacat     2520

caattcaaca gtaatgctgt tacagacatt aatttggata atgtttgcaa gaaaggaaat     2580

actttgttgt gggatatagt ccaagatgaa gatgcagtta atctttctga aggattaata     2640

aatgaagcag agaaacttct ttgttcgtta gtatgttggt ttacagatag acaaattcga     2700

atgagattca ttgaaggttg ccttgaaaac ttgggaaaca acagatcagt agtaatttca     2760

cttcgtcttc ttccaaaact atttggtact tttcagcagt ttgggagcag ttacgataca     2820

cactggataa caatgtgggc agaaaaagaa ctgaacatga tgaagctttt ctttgataat     2880

ttggtatact acattcaaac tgtgagagaa ggaagacaaa aacatgcact gtacagccat     2940

agtgctgaag ttcaagttcg tcttcaattc ttgacttgtg tattttcaac tctgggatca     3000

cctgatcatt tcaggttaag tttagagcaa gttgacatct tatggcattg tttagtagaa     3060

gattctgaat gttatgatga tgcactccat tggtttttaa atcaagttcg aagtaaagat     3120

caacatgcta tgggtatgga aacctacaaa catcttttcc tggagaagat gccccagcta     3180

aaacctgaaa caattagcat gactggctta aacctgtttc agcatctctg taacttggct     3240

cgattggcta ccagtgccta tgatggttgt tcaaattctg agctgtgtgg tatggaccaa     3300

ttttggggca ttgctttaag agcacaatct ggtgatgtca gtcgagcagc tatccagtat     3360

attaactcct attatattaa tggtaaaaca ggtttggaga aggagcaaga atttattagt     3420

aagtgcatgg agagtcttat gatagcttct agcagtcttg aacaggaatc acactcaagt     3480

ctcatggtta tagaaagagg actccttatg ctgaagacac atctggaagc gtttaggaga     3540

aggtttgcat atcatctgag acagtggcaa attgaaggca ctggtattag tagtcatttg     3600

aaagcactga gtgacaaaca gtctctgccg ctaagggttg tatgccagcc agctggactt     3660

cctgacaaga tgactattga aatgtatcct agtgaccagg tagcagatct tagggctgaa     3720

gtaactcatt ggtatgaaaa tttacagaaa gaacaaataa atcaacaagc tcagcttcag     3780

gagtttggtc aaagcaaccg aaaaggagag tttcctggag gcctcatggg acctgtcagg     3840

atgatttcat ctggacacga gttaacaaca gattatgatg aaaaagcact tcatgagctt     3900

ggttttaagg atatgcagat ggtatttgta tctttgggtg caccaaggag agagcggaaa     3960

ggggaaggtg ttcagctgcc agcatcttgc ctcccacccc ctcagaagga caacattcca     4020

atgcttttgc ttttacaaga gcctcattta actactcttt ttgatttatt agagatgctt     4080

gcatcattta aaccaccctc aggaaaagtg gcagtggatg atagtgagag cttacgatgt     4140

gaagaacttc atcttcatgc agaaaatctg tctaggcggg tctgggagct actgatgctt     4200

cttcctacat gtcctaatat gttgatggca ttccagaata tctcagatga gcagagtaat     4260

gatggattta attggaaaga acttctcaaa attaagagcg cccacaagct attgtatgct     4320

ctggaaatta ttgaagcact gggaaaacct aatagaagaa taaggaggga gtctacggga     4380

agttacagtg atctttatcc agattcagat gattcaagtg aagatcaagt ggaaaatagt     4440

aaaaattcct ggagttgcaa gtttgttgct gctggagggc ttcaacagtt attagaaatt     4500

tttaattctg gaattctaga gcctaaagag caggaatcat ggactgtgtg gcagctagac     4560

tgtcttgctt gcttgctgaa gttaatatgc cagtttgcag tagatccatc cgatttggat     4620

ttagcttatc atgatgtctt tgcctggtct ggtatagcgg aaagccatag gaaaagaacc     4680

tggcctggca aatcaaggaa ggctgctggt gatcatgcta agggtcttca tataccacga     4740

ttaacagagg tatttcttgt tcttgtccaa ggaaccagtt tgattcagcg acttatgtct     4800

gttgcttata cgtatgataa tctggctcct agagttttaa aagctcagtc tgatcacagg     4860

tctagacatg aagtttcaca ttattcaatg tggctcttgg tgagttgggc tcattgctgt     4920

tctttagtga aatctagcct tgctgatagc gatcatttac aagattggct aaagaaattg     4980

actctcctta ttcctgagac tgcagttcgt catgaatcat gcagtggtct ctataagtta     5040

tccctgtcag ggctggatgg aggagactca atcaatcgtt cttttctgct attggctgcc     5100

tcaacattat tgaaatttct tcctgatgct caagcactca aacctattag gatagatgat     5160

tatgaggaag aaccaatatt aaaaccagga tgtaaagagt atttttggtt gttatgcaaa     5220

ttagttgaca acatacatat aaaggacgct agtcagacaa cgctcctcga cttagatgcc     5280

ttggcaagac atttggctga ctgtattcga agtagggaga tccttgatca tcaggatggt     5340

aatgtagaag atgatgggct tacaggactc ctaaggcttg caacaagtgt tgttaaacac     5400

aaaccaccct ttaaattttc aagggaagga caggaatttt tgagagatat cttcaatctc     5460

ctgtttttgt tgccaagtct aaaggaccga caacagccaa agtgcaaatc acattcttca     5520

agagctgccg cttacgattt gttagtagag atggtaaagg ggtctgttga gaactacagg     5580

ctaatacaca actgggttat ggcacaacac atgcagtccc atgcacctta taaatgggat     5640

tactggcctc atgaagatgt ccgtgctgaa tgtagatttg ttggccttac taaccttgga     5700

gctacttgtt acttagcttc tactattcag caactttata tgatacctga ggcaagacag     5760

gctgtcttca ctgccaagta ttcagaggat atgaagcaca agaccactct tctggagctt     5820

cagaaaatgt ttacatattt aatggagagt gaatgcaaag catataatcc tagacctttc     5880

tgtaaaacat acaccatgga taagcagcct ctgaatactg gggaacagaa agatatgaca     5940

gagtttttta ctgatctaat taccaaaatc gaagaaatgt ctcccgaact gaaaaatacc     6000

gtcaaaagtt tatttggagg tgtaattaca aacaatgttg tatccttgga ttgtgaacat     6060

gttagtcaaa ctgctgaaga gttttatact gtgaggtgcc aagtggctga tatgaagaac     6120

atttatgaat ctcttgatga agttactata aaagacactt tggaaggtga taacatgtat     6180

acttgttctc attgtgggaa gaaagtacga gctgaaaaaa gggcatgttt taagaaattg     6240

cctcgcattt tgagtttcaa tactatgaga tacacattta atatggtcac gatgatgaaa     6300

gagaaagtga atacacactt ttccttccca ttacgtttgg acatgacgcc ctatacagaa     6360

gattttctta tgggaaagag tgagaggaaa gaaggtttta aagaagtcag tgatcattca     6420

aaagactcag agagctatga atatgacttg ataggagtga ctgttcacac aggaacggca     6480

gatggtggac actattatag ctttatcaga gatatagtaa atccccatgc ttataaaaac     6540

aataaatggt atctttttaa tgatgctgag gtaaaacctt ttgattctgc tcaacttgca     6600

tctgaatgtt ttggtggaga gatgacgacc aagacctatg attctgttac agataaattt     6660

atggacttct cttttgaaaa gacacacagt gcatatatgc tgttttacaa acgcatggaa     6720

ccagaggaag aaaatggcag agaatacaaa tttgatgttt cgtcagagtt actagagtgg     6780

atttggcatg ataacatgca gtttcttcaa gacaaaaaca tttttgaaca tacatatttt     6840

ggatttatgt ggcaattgtg tagttgtatt cccagtacat taccagatcc taaagctgtg     6900

tccttaatga cagcaaagtt aagcacttcc tttgtcctag agacatttat tcattctaaa     6960

gaaaagccca cgatgcttca gtggattgaa ctgttgacga aacagtttaa taatagtcag     7020

gcagcttgtg agtggttttt agatcgtatg gctgatgacg actggtggcc aatgcagata     7080

ctaattaagt gccctaatca aattgtgaga cagatgtttc agcgtttgtg tatccatgtg     7140

attcagaggc tgagacctgt gcatgctcat ctctatttgc agccaggaat ggaagatggg     7200

tcagatgata tggatacctc agtagaagat attggtggtc gttcatgtgt cactcgcttt     7260

gtgagaaccc tgttattaat tatggaacat ggtgtaaaac ctcacagtaa acatcttaca     7320

gagtattttg ccttccttta cgaatttgca aaaatgggtg aagaagagag ccaatttttg     7380

ctttcattgc aagctatatc tacaatggta catttttaca tgggaacaaa aggacctgaa     7440

aatcctcaag ttgaagtgtt atcagaggaa gaaggggaag aagaagagga ggaagaagat     7500

atcctctctc tggcagaaga aaaatacagg ccagctgccc ttgaaaagat gatagcttta     7560

gttgctcttt tggttgaaca gtctcgatca gaaaggcatt tgacattatc acagactgac     7620

atggcagcat taacaggagg aaagggattt cccttcttgt ttcaacatat tcgtgatggc     7680

atcaatataa gacaaacttg taatctgatt ttcagcctgt gtcgatacaa taatcgactt     7740

gcagaacata ttgtatctat gcttttcaca tcaatagcaa agttgactcc tgaggcagcc     7800

aatcctttct ttaagttgtt gactatgcta atggagtttg ctggtggacc tccaggaatg     7860

cctccctttg catcttatat tctgcagagg atatgggagg tgattgaata caatccttct     7920

cagtgtctag attggttggc agtgcagaca ccccgaaata aactggcaca cagctgggtc     7980

ttacagaata tggaaaactg ggtcgagcgg tttcttttgg ctcacaatta tcctagagtg     8040

aggacttctg cagcttatct tctggtgtcc cttataccaa gcaattcatt ccgtcagatg     8100

ttccggtcaa caaggtcttt gcacatccca acccgtgacc ttccactcag tccagacaca     8160

acagtagtcc tacatcaggt ctacaacgtg ctccttggtt tgctctcaag agccaaactt     8220

tatgttgatg ctgctgttca tggcactaca aagctagtgc cctattttag ctttatgact     8280

tactgtttaa tttccaaaac tgagaagctg atgttttcca catatttcat ggatttgtgg     8340

aaccttttcc agcctaaact ttctgagcca gcaatagcta caaatcacaa taaacaggct     8400

ttgctttcat tttggtacaa tgtctgtgct gactgtccag agaatatccg ccttattgtt     8460

cagaacccag tggtaaccaa gaacattgcc ttcaattaca tccttgctga ccatgatgat     8520

caggatgtgg tgctttttaa ccgtgggatg ctgccagcgt actatggcat tctgaggctc     8580

tgctgtgagc agtctcctgc attcacacga caactggctt ctcaccagaa catccagtgg     8640

gcctttaaga atcttacacc acatgccagc caataccctg gagcagtaga agaactgttt     8700

aacctgatgc agctgtttat agctcagagg ccagatatga gagaagaaga attagaagat     8760

attaaacagt tcaagaaaac aaccataagt tgttacttac gttgcttaga tggccgctcc     8820

tgctggacta ctttaataag tgccttcaga atactattag aatctgatga agacagactt     8880

cttgttgtat ttaatcgagg attgattcta atgacagagt ctttcaacac tttgcacatg     8940

atgtatcacg aagctacagc ttgccatgtg actggagatt tagtagaact tctgtcaata     9000

tttctttcgg ttttgaagtc tacacgccct tatcttcaga gaaaagatgt gaaacaagca     9060

ttaatccagt ggcaggagcg aattgaattt gcccataaac tgttaactct tcttaattcc     9120

tatagtcctc cagaacttag aaatgcctgt atagatgtcc tcaaggaact tgtacttttg     9180

agtccccatg attttcttca tactctggtt ccctttctac aacacaacca ttgtacttac     9240

catcacagta atataccaat gtctcttgga ccttatttcc cttgtcgaga aaatatcaag     9300

ctaataggag ggaaaagcaa tattcggcct ccgcgccctg aactcaatat gtgcctcttg     9360

cccacaatgg tggaaaccag taagggcaaa gatgacgttt atgatcgtat gctgctagac     9420

tacttctttt cttatcatca gttcatccat ctattatgcc gagttgcaat caactgtgaa     9480

aaatttactg aaacattagt taagctgagt gtcctagttg cctatgaagg tttgccactt     9540

catcttgcac tgttccccaa actttggact gagctatgcc agactcagtc tgctatgtca     9600

aaaaactgca tcaagctttt gtgtgaagat cctgttttcg cagaatatat taaatgtatc     9660

ctaatggatg aaagaacttt tttaaacaac aacattgtct acacgttcat gacacatttc     9720

cttctaaagg ttcaaagtca agtgttttct gaagcaaact gtgccaattt gatcagcact     9780

cttattacaa acttgataag ccagtatcag aacctacagt ctgatttctc caaccgagtt     9840

gaaatttcca aagcaagtgc ttctttaaat ggggacctga gggcactcgc tttgctcctg     9900

tcagtacaca ctcccaaaca gttaaaccca gctctaattc caactctgca agagctttta     9960

agcaaatgca ggacttgtct gcaacagaga aactcactcc aagagcaaga agccaaagaa    10020

agaaaaacta aagatgatga aggagcaact cccattaaaa ggcggcgtgt tagcagtgat    10080

gaggagcaca ctgtagacag ctgcatcagt gacatgaaaa cagaaaccag ggaggtcctg    10140

accccaacga gcacttctga caatgagacc agagactcct caattattga tccaggaact    10200

gagcaagatc ttccttcccc tgaaaatagt tctgttaaag aataccgaat ggaagttcca    10260

tcttcgtttt cagaagacat gtcaaatatc aggtcacagc atgcagaaga acagtccaac    10320

aatggtagat atgacgattg taaagaattt aaagacctcc actgttccaa ggattctacc    10380

ctagctgagg aagaatctga gttcccttct acttctatct ctgcagttct gtctgactta    10440

gctgacttga gaagctgtga tggccaagct ttgccctccc aggaccctga ggttgcttta    10500

tctctcagtt gtggccattc cagaggactc tttagtcata tgcagcaaca tgacatttta    10560

gataccctgt gtaggaccat tgaatctaca atccatgtcg tcacaaggat atctggcaaa    10620

ggaaaccaag ctgcttcttg a                                              10641


<210>  1138
<211>  303
<212>  DNA
<213>  Homo sapiens

<400>  1138
atgtctacag gtccaactgc tgccactggc agtaatcgaa gacttcagca gacacaaaat       60

caagtagatg aggtggtgga cataatgcga gttaacgtgg acaaggttct ggaaagagac      120

cagaagctct ctgagttaga cgaccgtgca gacgcactgc aggcaggcgc ttctcaattt      180

gaaacgagcg cagccaagtt gaagaggaaa tattggtgga agaattgcaa gatgtgggca      240

atcgggatta ctgttctggt tatcttcatc atcatcatca tcgtgtgggt tgtctcttca      300

tga                                                                    303


<210>  1139
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  1139
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atggggatga gctcaggttt ctacaaaaat gtggtgaaga ttcaaaagca tgttaccttc      780

aaccaagtga aaggcatttt cggcttcact gacagcgact gcattgggaa gatcagtttt      840

cctgccatcc aggctgctcc ctccttcagc aactcattcc cacagatctt ccgagacagg      900

acggatatcc agtgccttat cccatgtgcc attgaccagg atccttactt tagaatgaca      960

agggacgtcg cccccaggat cggctatcct aaaccagccc tgctgcactc caccttcttc     1020

ccagccctgc agggcgccca gaccaaaatg agtgccagcg accccaactc ctccatcttc     1080

ctcaccgaca cggccaagca gatcaaaacc aaggtcaata agcatgcgtt ttctggaggg     1140

agagacacca tcgaggagca caggcagttt gggggcaact gtgatgtgga cgtgtctttc     1200

atgtacctga ccttcttcct cgaggacgac gacaagctcg agcagatcag gaaggattac     1260

accagcggag ccatgctcac cggtgagctc aagaaggcac tcatagaggt tctgcagccc     1320

ttgatcgcag agcaccaggc ccggcgcaag gaggtcacgg atgagatagt gaaagagttc     1380

atgactcccc ggaagctgtc cttcgacttt cagtag                               1416


<210>  1140
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  1140
atgagtgggg gcccaatggg aggaaggccc gggggccgag gagcaccagc ggttcagcag       60

aacataccct ccaccctcct ccaggaccac gagaaccagc gactctttga gatgcttgga      120

cgaaaatgct tgacgctggc cactgcagtt gttcagctgt acctggcgct gccccctgga      180

gctgagcact ggaccaagga gcattgtggg gctgtgtgct tcgtgaagga taacccccag      240

aagtcctact tcatccgcct ttacggcctt caggctggtc ggctgctctg ggaacaggag      300

ctgtactcac agcttgtcta ctccaccccc acccccttct tccacacctt cgctggagat      360

gactgccaag cggggctgaa ctttgcagac gaggacgagg cccaggcctt ccgggccctc      420

gtgcaggaga agatacaaaa aaggaatcag aggcaaagtg gagacagacg ccagctaccc      480

ccaccaccaa caccagccaa tgaagagaga agaggagggc tcccacccct gcccctgcat      540

ccaggtggag accaaggagg ccctccagtg ggtccgctct ccctggggct ggcgacagtg      600

gacatccaga accctgacat cacgagttca cgataccgtg ggctcccagc acctggacct      660

agcccagctg ataagaaacg ctcagggaag aagaagatca gcaaagctga tattggtgca      720

cccagtggat tcaagcatgt cagccacgtg gggtgggacc cccagaatgg atttgacgtg      780

aacaacctcg acccagatct gcggagtctg ttctccaggg caggaatcag cgaggcccag      840

ctcaccgacg ccgagacctc taaacttatc tacgacttca ttgaggacca gggtgggctg      900

gaggctgtgc ggcaggagat gaggcgccag gagccacttc cgccgccccc accgccatct      960

cgaggaggga accagctccc ccggccccct attgtggggg gtaacaaggg tcgttctggt     1020

ccactgcccc ctgtaccttt ggggattgcc ccacccccac caacaccccg gggaccccca     1080

cccccaggcc gagggggccc tccaccacca ccccctccag ctactggacg ttctggacca     1140

ctgccccctc caccccctgg agctggtggg ccacccatgc caccaccacc gccaccaccg     1200

ccaccgccgc ccagctccgg gaatggacca gcccctcccc cactccctcc tgctctggtg     1260

cctgccgggg gcctggcccc tggtgggggt cggggagcgc ttttggatca aatccggcag     1320

ggaattcagc tgaacaagac ccctggggcc ccagagagct cagcgctgca gccaccacct     1380

cagagctcag agggactggt gggggccctg atgcacgtga tgcagaagag aagcagagcc     1440

atccactcct ccgacgaagg ggaggaccag gctggcgatg aagatgaaga tgatgaatgg     1500

gatgactga                                                             1509


<210>  1141
<211>  2082
<212>  DNA
<213>  Homo sapiens

<400>  1141
atgattgctc ctcttctttg tatcctgtct tataatttca acacatttgc gatactcaat       60

gtctattcta aattaaccat gttttgtacc acaaactcat tgcccatgga tctgttgctg      120

aaacaaggaa gtcttaaaca agaagtggaa tctttctgtt atcagattgt gtctgaatca      180

aatgatcaga aggttggaat attacaaagt gaagataagc agttgcaacc ttcagtttct      240

aaaaaatcag aaggtgagct ttccagggtc aaatttatat ccaattccaa caaaataaca      300

tttagtaaaa aaccaaaaag aagaaaatat gatgaaagtt atttgtcttt tggatttact      360

tacttcggaa atagagatgc acctcatgct cagtgtgtat tatgtaagaa aattttatca      420

aatagctctt tagcccctag taagcttcga agacatttgg aaactaaaca tgctgcatat      480

aaagacaaag acataagctt tttcaagcaa catctcgatt cacctgaaaa taataaaccc      540

ccaacaccta aaattgtgaa tacagataat gaaagtgcta cagaagcatc atacaatgta      600

agttaccata tagcgctgag tggagaggct catactattg gagaattgct tatcaaacct      660

tgtgcaaaag atgtagtgat gcggatgttt gatgaacaat atagtaaaaa aatagatgca      720

gtacagctat caaacagtac tgttgcacgt cgaattaagg atctagctgc tgacattgaa      780

gaagagcttg tttgtagact gaaaatttgc gatgggtttt cactgcaact agatgaatca      840

gctgatgttt caggacttgc tgtgctgctt gtgtttgttc gttataggtt taataagtct      900

attgaggaag acctactcct gtgtgaatct ttgcaaagta atgctaccgg tgaagaaata      960

ttcaactgta tcaacagttt tatgcagaaa catgaaattg aatgggaaaa atgtgttgat     1020

gtttgtagtg atgcttctag ggcagtggat gggaaaattg ccgaagctgt caccttaata     1080

aaatatgtgg ctcccgaaag caccagtagt cactgcctat tatacagaca tgcactggca     1140

gttaaaataa tgcctacatc tctaaaaaat gtgctagacc aggcagtaca aatcatcaat     1200

tatattaaag ctcgaccaca tcaatccaga ctattaaaaa ttttatgtga ggaaatgggt     1260

gctcagcaca cagcacttct tctaaataca gaggtgaggt ggctttctcg aggtaaagtt     1320

cttgtaagac tttttgaact tcgtcgtgaa cttttggttt tcatggattc tgcttttcga     1380

ctatctgatt gtttaacaaa ttcatcttgg ctgctaagac ttgcatatct tgcagatatt     1440

tttactaaat taaatgaagt taatttgtca atgcaaggaa aaaatgtgac cgtttttaca     1500

gtatttgata aaatgtcgtc attgttaaga aaattggaat tttgggcctc atctgtagaa     1560

gaagaaaact ttgattgttt tcctacactc agtgattttt tgactgaaat taattctaca     1620

gttgataaag atatttgcag tgccattgtg cagcacctaa ggggtttgcg cgctactctg     1680

ttaaaatact ttcctgtaac aaatgacaat aatgcttggg ttagaaatcc atttacagtt     1740

actgttaaac cagcttcatt agtagcacgg gactatgaga gcctgattga tttaacatct     1800

gattctcaag tgaagcaaaa ttttagtgaa ctttcactaa atgatttttg gagtagccta     1860

attcaggaat acccaagcat tgcaaggcgt gcagtgcgtg tacttcttcc ttttgctaca     1920

atgcacctgt gtgaaacggg gttttcatat tacgctgcaa caaaaacaaa atataggaaa     1980

agacttgatg ctgcacctca tatgcgaatc cgacttagca atattacacc taatattaag     2040

cggatatgtg ataaaaagac acaaaaacac tgttctcatt aa                        2082


<210>  1142
<211>  1809
<212>  DNA
<213>  Homo sapiens

<400>  1142
atggcacgtt taacaaaaag acgacaggcg gatacaaaag ctatccagca tctttgggca       60

gccattgaga ttatacggaa ccagaagcag attgccaaca ttgaccgtat tacaaagtat      120

atgtctcgag tccacggtat gcaccctaaa gagaccaccc gtcagctgag cttagctgtg      180

aaagatggtc ttattgtcga aactctaaca gtgggctgca aaggttcaaa agctggtatt      240

gaacaagaag gatattggtt gccaggagat gagattgact gggaaacaga aaatcatgac      300

tggtattgtt ttgaatgcca tttgcctgga gaggtgttga tatgtgacct gtgttttcgt      360

gtgtatcatt ccaagtgttt gtctgatgag ttcaggctta gagacagcag tagtccctgg      420

cagtgcccag tttgcaggag cattaagaag aagaatacaa acaaacagga gatgggcaca      480

tacctcagat tcattgtctc ccgcatgaag gagagggcta tagatcttaa taaaaagggg      540

aaggacaata aacacccgat gtacaggagg ctggtgcact cagctgtgga cgttcccacc      600

attcaagaga aagtgaatga agggaaatac cgaagttatg aagagttcaa agctgatgcc      660

caattgcttc tccacaatac cgtgattttc tatggagcag acagtgagca agctgacatt      720

gcgaggatgc tatataaaga cacatgtcat gagctggatg aactgcagct ttgcaagaat      780

tgcttttact tgtcaaatgc tcgtcctgac aactggttct gttatccttg tatacctaat      840

catgagctgg tttgggctaa aatgaaaggt tttgggtttt ggccagccaa agtcatgcag      900

aaagaagaca atcaagtcga cgttcgcttc tttggccacc accaccagag ggcctggatt      960

ccttctgaaa acattcaaga tatcacagtc aacattcatc ggctgcacgt gaagcgcagt     1020

atgggttgga aaaaggcctg tgatgagctg gagctgcatc agcgtttcct acgagaaggg     1080

agattttgga aatctaagaa tgaggaccga ggtgaggaag aggcagaatc cagtatctcc     1140

tccaccagta atgagcagct aaaggtcact caagaaccaa gagcaaagaa aggacgacgt     1200

aatcaaagtg tggagcccaa aaaggaagaa ccagagcctg aaacagaagc agtaagttct     1260

agccaggaaa tacccacgat gcctcagccc atcgaaaaag tctccgtgtc aactcagaca     1320

aagaagttaa gtgcctcttc accaagaatg ctgcatcgga gcacccagac cacaaacgac     1380

ggcgtgtgtc agagcatgtg ccatgacaaa tacaccaaga tcttcaatga cttcaaagac     1440

cggatgaagt cggaccacaa gcgggagaca gagcgtgttg tccgagaagc tctggagaag     1500

ctgcgttctg aaatggaaga agaaaagaga caagctgtaa ataaagctgt agccaacatg     1560

cagggtgaga tggacagaaa atgtaagcaa gtaaaggaaa agtgtaagga agaatttgta     1620

gaagaaatca agaagctggc aacacagcac aagcaactga tttctcagac caagaagaag     1680

cagtggtgct acaactgtga ggaggaggcc atgtaccact gctgctggaa cacatcctac     1740

tgctccatca agtgccagca ggagcactgg cacgcggagc acaagcgcac ctgccgccgg     1800

aaaagatga                                                             1809


<210>  1143
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  1143
atgctggaga actacaagaa tttggccaca gtaggatatc agctcttcaa acccagtctg       60

atctcttggc tggaacaaga agagtctagg acagtgcaga gaggtgattt ccaagcttca      120

gaatggaaag tgcaacttaa aaccaaagag ttagcccttc agcaggatgt tttgggggag      180

ccaacctcca gtgggattca aatgatagga agccacaacg gaggggaggt cagtgatgtt      240

aagcaatgtg gagatgtctc cagtgaacac tcatgcctta agacacatgt gagaactcaa      300

aatagtgaga acacatttga gtgttatctg tatggagtag acttccttac tctgcacaag      360

aaaacctcta ctggagagca acgttctgta tttagtcagt gtggaaaagc cttcagcctg      420

aacccagatg ttgtttgcca gagaacgtgc acaggagaga aagcttttga ttgcagtgac      480

tctgggaaat ccttcattaa tcattcacac cttcagggac atttaagaac tcacaatgga      540

gaaagtctcc atgaatggaa ggaatgtggg agaggcttta ttcactccac agaccttgct      600

gtgcgtatac aaactcacag gtcagaaaaa ccctacaaat gtaaggaatg tggaaaagga      660

tttagatatt ctgcatacct taatattcac atgggaaccc acactggaga caatccctat      720

gagtgtaagg agtgtgggaa agccttcacc aggtcttgtc aacttactca gcacagaaaa      780

actcacactg gagagaaacc ttataaatgt aaggattgtg ggagagcctt cactgtttcc      840

tcttgcttaa gtcaacatat gaaaatccat gtgggtgaga agccttatga atgcaaggaa      900

tgtgggatag ccttcactag atcttctcaa cttactgaac atttaaaaac tcacactgca      960

aaggatccct ttgaatgtaa gatatgtgga aaatccttta gaaattcctc atgcctcagt     1020

gatcactttc gaattcacac tggaataaaa ccctataaat gtaaggattg tgggaaagcc     1080

ttcactcaga actcagacct tactaagcat gcacgaactc acagtggaga gaggccctat     1140

gaatgtaagg aatgtggaaa ggcctttgcc agatcctctc gccttagtga acatacaaga     1200

actcacactg gagagaagcc ttttgaatgt gtcaaatgtg ggaaagcctt tgctatttct     1260

tcaaatctta gtggacattt gagaattcac actggagaga agccctttga gtgcctggaa     1320

tgtggtaaag catttacgca ttcctccagt cttaataatc acatgcggac ccacagcgcc     1380

aaaaaaccat tcacgtgtat ggaatgtggc aaagctttta agtttcccac gtgtgttaac     1440

cttcacatgc ggatccacac tggagaaaaa ccctacaaat gtaaacagtg tgggaaatcc     1500

ttcagttact ccaattcgtt tcagttacat gaacgaactc acactggaga gaaaccctat     1560

gaatgtaagg agtgcgggaa agccttcagt tcttccagtt cctttcgaaa tcatgaaaga     1620

aggcatgcgg atgagagact gtcagcataa                                      1650


<210>  1144
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  1144

Met Ala Lys Arg Ile Lys Ala Lys Pro Thr Ser Asp Lys Pro Gly Ser 
1               5                   10                  15      


Pro Tyr Arg Ser Val Thr His Phe Asp Ser Leu Ala Val Ile Asp Ile 
            20                  25                  30          


Pro Gly Ala Asp Thr Leu Asp Lys Leu Phe Asp His Ala Val Ser Lys 
        35                  40                  45              


Phe Gly Lys Lys Asp Ser Leu Gly Thr Arg Glu Ile Leu Ser Glu Glu 
    50                  55                  60                  


Asn Glu Met Gln Pro Asn Gly Lys Val Phe Lys Lys Leu Ile Leu Gly 
65                  70                  75                  80  


Asn Tyr Lys Trp Met Asn Tyr Leu Glu Val Asn Arg Arg Val Asn Asn 
                85                  90                  95      


Phe Gly Ser Gly Leu Thr Ala Leu Gly Leu Lys Pro Lys Asn Thr Ile 
            100                 105                 110         


Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala Gln Thr 
        115                 120                 125             


Cys Phe Lys Tyr Asn Phe Pro Leu Val Thr Leu Tyr Ala Thr Leu Gly 
    130                 135                 140                 


Lys Glu Ala Val Val His Gly Leu Asn Glu Ser Glu Ala Ser Tyr Leu 
145                 150                 155                 160 


Ile Thr Ser Val Glu Leu Leu Glu Ser Lys Leu Lys Thr Ala Leu Leu 
                165                 170                 175     


Asp Ile Ser Cys Val Lys His Ile Ile Tyr Val Asp Asn Lys Ala Ile 
            180                 185                 190         


Asn Lys Ala Glu Tyr Pro Glu Gly Phe Glu Ile His Ser Met Gln Ser 
        195                 200                 205             


Val Glu Glu Leu Gly Ser Asn Pro Glu Asn Leu Gly Ile Pro Pro Ser 
    210                 215                 220                 


Arg Pro Thr Pro Ser Asp Met Ala Ile Val Met Tyr Thr Ser Gly Ser 
225                 230                 235                 240 


Thr Gly Arg Pro Lys Gly Val Met Met His His Ser Asn Leu Ile Ala 
                245                 250                 255     


Gly Met Thr Gly Gln Cys Glu Arg Ile Pro Gly Leu Gly Pro Lys Asp 
            260                 265                 270         


Thr Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu Thr Ala 
        275                 280                 285             


Glu Ile Ser Cys Phe Thr Tyr Gly Cys Arg Ile Gly Tyr Ser Ser Pro 
    290                 295                 300                 


Leu Thr Leu Ser Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser Lys Gly 
305                 310                 315                 320 


Asp Cys Thr Val Leu Lys Pro Thr Leu Met Ala Ala Val Pro Glu Ile 
                325                 330                 335     


Met Asp Arg Ile Tyr Lys Asn Val Met Ser Lys Val Gln Glu Met Asn 
            340                 345                 350         


Tyr Ile Gln Lys Thr Leu Phe Lys Ile Gly Tyr Asp Tyr Lys Leu Glu 
        355                 360                 365             


Gln Ile Lys Lys Gly Tyr Asp Ala Pro Leu Cys Asn Leu Leu Leu Phe 
    370                 375                 380                 


Lys Lys Val Lys Ala Leu Leu Gly Gly Asn Val Arg Met Met Leu Ser 
385                 390                 395                 400 


Gly Gly Ala Pro Leu Ser Pro Gln Thr His Arg Phe Met Asn Val Cys 
                405                 410                 415     


Phe Cys Cys Pro Ile Gly Gln Gly Tyr Gly Leu Thr Glu Ser Cys Gly 
            420                 425                 430         


Ala Gly Thr Val Thr Glu Val Thr Asp Tyr Thr Thr Gly Arg Val Gly 
        435                 440                 445             


Ala Pro Leu Ile Cys Cys Glu Ile Lys Leu Lys Asp Trp Gln Glu Gly 
    450                 455                 460                 


Gly Tyr Thr Ile Asn Asp Lys Pro Asn Pro Arg Gly Glu Ile Val Ile 
465                 470                 475                 480 


Gly Gly Gln Asn Ile Ser Met Gly Tyr Phe Lys Asn Glu Glu Lys Thr 
                485                 490                 495     


Ala Glu Asp Tyr Ser Val Asp Glu Asn Gly Gln Arg Trp Phe Cys Thr 
            500                 505                 510         


Gly Asp Ile Gly Glu Phe His Pro Asp Gly Cys Leu Gln Ile Ile Asp 
        515                 520                 525             


Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val Ser Leu 
    530                 535                 540                 


Gly Lys Val Glu Ala Ala Leu Lys Asn Cys Pro Leu Ile Asp Asn Ile 
545                 550                 555                 560 


Cys Ala Phe Ala Lys Ser Asp Gln Ser Tyr Val Ile Ser Phe Val Val 
                565                 570                 575     


Pro Asn Gln Lys Arg Leu Thr Leu Leu Ala Gln Gln Lys Gly Val Glu 
            580                 585                 590         


Gly Thr Trp Val Asp Ile Cys Asn Asn Pro Ala Met Glu Ala Glu Ile 
        595                 600                 605             


Leu Lys Glu Ile Arg Glu Ala Ala Asn Ala Met Lys Leu Glu Arg Phe 
    610                 615                 620                 


Glu Ile Pro Ile Lys Val Arg Leu Ser Pro Glu Pro Trp Thr Pro Glu 
625                 630                 635                 640 


Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu Leu Arg 
                645                 650                 655     


Asn His Tyr Leu Lys Asp Ile Glu Arg Met Tyr Gly Gly Lys 
            660                 665                 670 


<210>  1145
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1145

Met Thr Ser Val Arg Glu Asn Ile Leu Phe Gly Met Gly Asn Pro Leu 
1               5                   10                  15      


Leu Asp Ile Ser Ala Val Val Asp Lys Asp Phe Leu Asp Lys Tyr Ser 
            20                  25                  30          


Leu Lys Pro Asn Asp Gln Ile Leu Ala Glu Asp Lys His Lys Glu Leu 
        35                  40                  45              


Phe Asp Glu Leu Val Lys Lys Phe Lys Val Glu Tyr His Ala Gly Gly 
    50                  55                  60                  


Ser Thr Gln Asn Ser Ile Lys Val Ala Gln Trp Met Ile Gln Gln Pro 
65                  70                  75                  80  


His Lys Ala Ala Thr Phe Phe Gly Cys Ile Gly Ile Asp Lys Phe Gly 
                85                  90                  95      


Glu Ile Leu Lys Arg Lys Ala Ala Glu Ala His Val Asp Ala His Tyr 
            100                 105                 110         


Tyr Glu Gln Asn Glu Gln Pro Thr Gly Thr Cys Ala Ala Cys Ile Thr 
        115                 120                 125             


Gly Asp Asn Arg Ser Leu Ile Ala Asn Leu Ala Ala Ala Asn Cys Tyr 
    130                 135                 140                 


Lys Lys Glu Lys His Leu Asp Leu Glu Lys Asn Trp Met Leu Val Glu 
145                 150                 155                 160 


Lys Ala Arg Val Cys Tyr Ile Ala Gly Phe Phe Leu Thr Val Ser Pro 
                165                 170                 175     


Glu Ser Val Leu Lys Val Ala His His Ala Ser Glu Asn Asn Arg Ile 
            180                 185                 190         


Phe Thr Leu Asn Leu Ser Ala Pro Phe Ile Ser Gln Phe Tyr Lys Glu 
        195                 200                 205             


Ser Leu Met Lys Val Met Pro Tyr Val Asp Ile Leu Phe Gly Asn Glu 
    210                 215                 220                 


Thr Glu Ala Ala Thr Phe Ala Arg Glu Gln Gly Phe Glu Thr Lys Asp 
225                 230                 235                 240 


Ile Lys Glu Ile Ala Lys Lys Thr Gln Ala Leu Pro Lys Met Asn Ser 
                245                 250                 255     


Lys Arg Gln Arg Ile Val Ile Phe Thr Gln Gly Arg Asp Asp Thr Ile 
            260                 265                 270         


Met Ala Thr Glu Ser Glu Val Thr Ala Phe Ala Val Leu Asp Gln Asp 
        275                 280                 285             


Gln Lys Glu Ile Ile Asp Thr Asn Gly Ala Gly Asp Ala Phe Val Gly 
    290                 295                 300                 


Gly Phe Leu Ser Gln Leu Val Ser Asp Lys Pro Leu Thr Glu Cys Ile 
305                 310                 315                 320 


Arg Ala Gly His Tyr Ala Ala Ser Ile Ile Ile Arg Arg Thr Gly Cys 
                325                 330                 335     


Thr Phe Pro Glu Lys Pro Asp Phe His 
            340                 345 


<210>  1146
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  1146

Met Ala Ala Gly Gly Asp His Gly Ser Pro Asp Ser Tyr Arg Ser Pro 
1               5                   10                  15      


Leu Ala Ser Arg Tyr Ala Ser Pro Glu Met Cys Phe Val Phe Ser Asp 
            20                  25                  30          


Arg Tyr Lys Phe Arg Thr Trp Arg Gln Leu Trp Leu Trp Leu Ala Glu 
        35                  40                  45              


Ala Glu Gln Thr Leu Gly Leu Pro Ile Thr Asp Glu Gln Ile Gln Glu 
    50                  55                  60                  


Met Lys Ser Asn Leu Glu Asn Ile Asp Phe Lys Met Ala Ala Glu Glu 
65                  70                  75                  80  


Glu Lys Arg Leu Arg His Asp Val Met Ala His Val His Thr Phe Gly 
                85                  90                  95      


His Cys Cys Pro Lys Ala Ala Gly Ile Ile His Leu Gly Ala Thr Ser 
            100                 105                 110         


Cys Tyr Val Gly Asp Asn Thr Asp Leu Ile Ile Leu Arg Asn Ala Leu 
        115                 120                 125             


Asp Leu Leu Leu Pro Lys Leu Ala Arg Val Ile Ser Arg Leu Ala Asp 
    130                 135                 140                 


Phe Ala Lys Glu Arg Ala Ser Leu Pro Thr Leu Gly Phe Thr His Phe 
145                 150                 155                 160 


Gln Pro Ala Gln Leu Thr Thr Val Gly Lys Arg Cys Cys Leu Trp Ile 
                165                 170                 175     


Gln Asp Leu Cys Met Asp Leu Gln Asn Leu Lys Arg Val Arg Asp Asp 
            180                 185                 190         


Leu Arg Phe Arg Gly Val Lys Gly Thr Thr Gly Thr Gln Ala Ser Phe 
        195                 200                 205             


Leu Gln Leu Phe Glu Gly Asp Asp His Lys Val Glu Gln Leu Asp Lys 
    210                 215                 220                 


Met Val Thr Glu Lys Ala Gly Phe Lys Arg Ala Phe Ile Ile Thr Gly 
225                 230                 235                 240 


Gln Thr Tyr Thr Arg Lys Val Asp Ile Glu Val Leu Ser Val Leu Ala 
                245                 250                 255     


Ser Leu Gly Ala Ser Val His Lys Ile Cys Thr Asp Ile Arg Leu Leu 
            260                 265                 270         


Ala Asn Leu Lys Glu Met Glu Glu Pro Phe Glu Lys Gln Gln Ile Gly 
        275                 280                 285             


Ser Ser Ala Met Pro Tyr Lys Arg Asn Pro Met Arg Ser Glu Arg Cys 
    290                 295                 300                 


Cys Ser Leu Ala Arg His Leu Met Thr Leu Val Met Asp Pro Leu Gln 
305                 310                 315                 320 


Thr Ala Ser Val Gln Trp Phe Glu Arg Thr Leu Asp Asp Ser Ala Asn 
                325                 330                 335     


Arg Arg Ile Cys Leu Ala Glu Ala Phe Leu Thr Ala Asp Thr Ile Leu 
            340                 345                 350         


Asn Thr Leu Gln Asn Ile Ser Glu Gly Leu Val Val Tyr Pro Lys Val 
        355                 360                 365             


Ile Glu Arg Arg Ile Arg Gln Glu Leu Pro Phe Met Ala Thr Glu Asn 
    370                 375                 380                 


Ile Ile Met Ala Met Val Lys Ala Gly Gly Ser Arg Gln Asp Cys His 
385                 390                 395                 400 


Glu Lys Ile Arg Val Leu Ser Gln Gln Ala Ala Ser Val Val Lys Gln 
                405                 410                 415     


Glu Gly Gly Asp Asn Asp Leu Ile Glu Arg Ile Gln Val Asp Ala Tyr 
            420                 425                 430         


Phe Ser Pro Ile His Ser Gln Leu Asp His Leu Leu Asp Pro Ser Ser 
        435                 440                 445             


Phe Thr Gly Arg Ala Ser Gln Gln Val Gln Arg Phe Leu Glu Glu Glu 
    450                 455                 460                 


Val Tyr Pro Leu Leu Lys Pro Tyr Glu Ser Val Met Lys Val Lys Ala 
465                 470                 475                 480 


Glu Leu Cys Leu 
                


<210>  1147
<211>  2275
<212>  PRT
<213>  Homo sapiens

<400>  1147

Met Ala Ala Glu Arg Arg Cys Gly Ser Met Arg Asp Leu Arg Ala Gln 
1               5                   10                  15      


Val Thr Ser Gly Leu Leu Pro Phe Pro Glu Val Thr Leu Gln Ala Leu 
            20                  25                  30          


Gly Glu Asp Glu Ile Thr Leu Glu Ser Val Leu Arg Gly Lys Phe Ala 
        35                  40                  45              


Ala Gly Lys Asn Gly Leu Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu 
    50                  55                  60                  


Val Val Asn Ser Ile Thr Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Gly Val Asn Glu Gln Pro Pro Val Val Leu Ala Val Lys Glu Phe Ser 
                85                  90                  95      


Trp Gln Lys Arg Thr Gly Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly 
            100                 105                 110         


Ser Val Leu Cys Leu Tyr Asp Leu Gly Ile Ser Lys Val Val Lys Ala 
        115                 120                 125             


Val Val Leu Pro Gly Arg Val Thr Ala Ile Glu Pro Ile Ile Asn His 
    130                 135                 140                 


Gly Gly Ala Ser Ala Ser Thr Gln His Leu His Pro Ser Leu Arg Trp 
145                 150                 155                 160 


Leu Phe Gly Val Ala Ala Val Val Thr Asp Val Gly Gln Ile Leu Leu 
                165                 170                 175     


Val Asp Leu Cys Leu Asp Asp Leu Ser Cys Asn Gln Asn Glu Val Glu 
            180                 185                 190         


Ala Ser Asp Leu Glu Val Leu Thr Gly Ile Pro Ala Glu Val Pro His 
        195                 200                 205             


Ile Arg Glu Ser Val Met Arg Gln Gly Arg His Leu Cys Phe Gln Leu 
    210                 215                 220                 


Val Ser Pro Thr Gly Thr Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg 
225                 230                 235                 240 


Thr Asn Gln Leu Ala Val Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp 
                245                 250                 255     


Asn Met Lys Ser Met Lys Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly 
            260                 265                 270         


Gln Val Pro Val Tyr Ala Val Thr Phe Gln Glu Pro Glu Asn Asp Pro 
        275                 280                 285             


Arg Asn Cys Cys Tyr Leu Trp Ala Val Gln Ser Thr Gln Asp Ser Glu 
    290                 295                 300                 


Gly Asp Val Leu Ser Leu His Leu Leu Gln Leu Ala Phe Gly Asn Arg 
305                 310                 315                 320 


Lys Cys Leu Ala Ser Gly Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys 
                325                 330                 335     


Glu Glu Arg Tyr Thr Leu Asp Leu Thr Gly Gly Met Phe Pro Leu Arg 
            340                 345                 350         


Gly Gln Thr Ser Asn Thr Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys 
        355                 360                 365             


Phe Arg Ser His Gly Asp Arg Glu Glu Gly Val Asn Glu Ala Leu Ser 
    370                 375                 380                 


Pro Asp Thr Ser Val Ser Val Phe Thr Trp Gln Val Asn Ile Tyr Gly 
385                 390                 395                 400 


Gln Gly Lys Pro Ser Val Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp 
                405                 410                 415     


Tyr His Ala Gln Met Pro Asp Ser Leu Arg Ser Gly Glu Tyr Leu His 
            420                 425                 430         


Asn Cys Ser Tyr Phe Ala Leu Trp Ser Leu Glu Ser Val Val Ser Arg 
        435                 440                 445             


Thr Ser Pro His Gly Ile Leu Asp Ile Leu Val His Glu Arg Ser Leu 
    450                 455                 460                 


Asn Arg Gly Val Pro Pro Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn 
465                 470                 475                 480 


Pro Ser Thr Tyr Asn Phe Asp Ala Thr Cys Leu Leu Asn Ser Gly Val 
                485                 490                 495     


Val His Leu Thr Cys Thr Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu 
            500                 505                 510         


Lys Lys Ser Gly Pro Ser Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn 
        515                 520                 525             


Arg Cys Leu Val Ala Gly Leu Leu Ser Pro Arg Phe Val Asp Val Gln 
    530                 535                 540                 


Pro Ser Ser Leu Ser Gln Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala 
545                 550                 555                 560 


Ala Ile Gln Thr Ser Ser Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg 
                565                 570                 575     


Trp Ile Thr Glu Glu Gln Pro Asn Ser Ala Thr Asn Leu Arg Phe Val 
            580                 585                 590         


Leu Glu Trp Thr Trp Asn Lys Val Val Leu Thr Lys Glu Glu Phe Asp 
        595                 600                 605             


Arg Leu Cys Val Pro Leu Phe Asp Gly Ser Cys His Phe Met Asp Pro 
    610                 615                 620                 


Gln Thr Ile Gln Ser Ile Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu 
625                 630                 635                 640 


Asn Ile Val Leu Ser Cys Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu 
                645                 650                 655     


Arg Gly Leu Ile Asp Leu Ser Asn Lys Phe Val Val Ser His Leu Ile 
            660                 665                 670         


Cys Gln Tyr Ala Gln Val Val Leu Trp Phe Ser His Ser Gly Leu Leu 
        675                 680                 685             


Pro Glu Gly Ile Asp Asp Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn 
    690                 695                 700                 


Tyr Pro Val Ile Gln Asn Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu 
705                 710                 715                 720 


Arg Leu Ser Arg Gly Lys Trp Asn Pro Asp Cys Leu Met Ile Asp Gly 
                725                 730                 735     


Leu Val Ser Gln Leu Gly Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp 
            740                 745                 750         


Glu Gly Gly Thr Gly Lys Tyr Pro Pro Ala Ser Leu His Ala Val Leu 
        755                 760                 765             


Asp Met Tyr Leu Leu Asp Gly Val Thr Glu Ala Ala Lys His Ser Ile 
    770                 775                 780                 


Thr Ile Tyr Leu Leu Leu Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr 
785                 790                 795                 800 


Asp Thr Pro Ile Glu Ser Phe Pro Thr Val Phe Ala Ile Ser Trp Gly 
                805                 810                 815     


Gln Val Lys Leu Ile Gln Gly Phe Trp Leu Ile Asp His Asn Asp Tyr 
            820                 825                 830         


Glu Ser Gly Leu Asp Leu Leu Phe His Pro Ala Thr Ala Lys Pro Leu 
        835                 840                 845             


Ser Trp Gln His Ser Lys Ile Ile Gln Ala Phe Met Ser Gln Gly Glu 
    850                 855                 860                 


His Arg Gln Ala Leu Arg Tyr Ile Gln Thr Met Lys Pro Thr Val Ser 
865                 870                 875                 880 


Ser Gly Asn Asp Val Ile Leu His Leu Thr Val Leu Leu Phe Asn Arg 
                885                 890                 895     


Cys Met Val Glu Ala Trp Asn Phe Leu Arg Gln His Cys Asn Arg Leu 
            900                 905                 910         


Asn Ile Glu Glu Leu Leu Lys His Met Tyr Glu Val Cys Gln Glu Met 
        915                 920                 925             


Gly Leu Met Glu Asp Leu Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln 
    930                 935                 940                 


Glu Cys Leu Val Lys Phe Leu Gln Ser Ser Ala Ser Val Gln Asn His 
945                 950                 955                 960 


Glu Phe Leu Leu Val His His Leu Gln Arg Ala Asn Tyr Val Pro Ala 
                965                 970                 975     


Leu Lys Leu Asn Gln Thr Leu Lys Ile Asn Val Met Asn Asp Arg Asp 
            980                 985                 990         


Pro Arg Leu Arg Glu Arg Ser Leu  Ala Arg Asn Ser Ile  Leu Asp Gln 
        995                 1000                 1005             


Tyr Gly  Lys Ile Leu Pro Arg  Val His Arg Lys Leu  Ala Ile Glu 
    1010                 1015                 1020             


Arg Ala  Lys Pro Tyr His Leu  Ser Thr Ser Ser Val  Phe Arg Leu 
    1025                 1030                 1035             


Val Ser  Arg Pro Lys Pro Leu  Ser Ala Val Pro Lys  Gln Val Val 
    1040                 1045                 1050             


Thr Gly  Thr Val Leu Thr Arg  Ser Val Phe Ile Asn  Asn Val Leu 
    1055                 1060                 1065             


Ser Lys  Ile Gly Glu Val Trp  Ala Ser Lys Glu Pro  Ile Asn Ser 
    1070                 1075                 1080             


Thr Thr  Pro Phe Asn Ser Ser  Lys Ile Glu Glu Pro  Ser Pro Ile 
    1085                 1090                 1095             


Val Tyr  Ser Leu Pro Ala Pro  Glu Leu Pro Glu Ala  Phe Phe Gly 
    1100                 1105                 1110             


Thr Pro  Ile Ser Lys Ala Ser  Gln Lys Ile Ser Arg  Leu Leu Asp 
    1115                 1120                 1125             


Leu Val  Val Gln Pro Val Pro  Arg Pro Ser Gln Cys  Ser Glu Phe 
    1130                 1135                 1140             


Ile Gln  Gln Ser Ser Met Lys  Ser Pro Leu Tyr Leu  Val Ser Arg 
    1145                 1150                 1155             


Ser Leu  Pro Ser Ser Ser Gln  Leu Lys Gly Ser Pro  Gln Ala Ile 
    1160                 1165                 1170             


Ser Arg  Ala Ser Glu Leu His  Leu Leu Glu Thr Pro  Leu Val Val 
    1175                 1180                 1185             


Lys Lys  Ala Lys Ser Leu Ala  Met Ser Val Thr Thr  Ser Gly Phe 
    1190                 1195                 1200             


Ser Glu  Phe Thr Pro Gln Ser  Ile Leu Arg Ser Thr  Leu Arg Ser 
    1205                 1210                 1215             


Thr Pro  Leu Ala Ser Pro Ser  Pro Ser Pro Gly Arg  Ser Pro Gln 
    1220                 1225                 1230             


Arg Leu  Lys Glu Thr Arg Ile  Ser Phe Val Glu Glu  Asp Val His 
    1235                 1240                 1245             


Pro Lys  Trp Ile Pro Gly Ala  Ala Asp Asp Ser Lys  Leu Glu Val 
    1250                 1255                 1260             


Phe Thr  Thr Pro Lys Lys Cys  Ala Val Pro Val Glu  Thr Glu Trp 
    1265                 1270                 1275             


Leu Lys  Ser Lys Asp Arg Thr  Thr Ser Phe Phe Leu  Asn Ser Pro 
    1280                 1285                 1290             


Glu Lys  Glu His Gln Glu Met  Asp Glu Gly Ser Gln  Ser Leu Glu 
    1295                 1300                 1305             


Lys Leu  Asp Val Ser Lys Gly  Asn Ser Ser Val Ser  Ile Thr Ser 
    1310                 1315                 1320             


Asp Glu  Thr Thr Leu Glu Tyr  Gln Asp Ala Pro Ser  Pro Glu Asp 
    1325                 1330                 1335             


Leu Glu  Glu Thr Val Phe Thr  Ala Ser Lys Pro Lys  Ser Ser Ser 
    1340                 1345                 1350             


Thr Ala  Leu Thr Thr Asn Val  Thr Glu Gln Thr Glu  Lys Asp Gly 
    1355                 1360                 1365             


Asp Lys  Asp Val Phe Ala Ser  Glu Val Thr Pro Ser  Asp Leu Gln 
    1370                 1375                 1380             


Lys Gln  Met Gly Asn Leu Glu  Asp Ala Glu Thr Lys  Asp Leu Leu 
    1385                 1390                 1395             


Val Ala  Ala Glu Ala Phe Ser  Glu Leu Asn His Leu  Ser Pro Val 
    1400                 1405                 1410             


Gln Gly  Thr Glu Ala Ser Leu  Cys Ala Pro Ser Val  Tyr Glu Gly 
    1415                 1420                 1425             


Lys Ile  Phe Thr Gln Lys Ser  Lys Val Pro Val Leu  Asp Glu Gly 
    1430                 1435                 1440             


Leu Thr  Ser Val Glu Thr Tyr  Thr Pro Ala Ile Arg  Ala Asn Asp 
    1445                 1450                 1455             


Asn Lys  Ser Met Ala Asp Val  Leu Gly Asp Gly Gly  Asn Ser Ser 
    1460                 1465                 1470             


Leu Thr  Ile Ser Glu Gly Pro  Ile Val Ser Glu Arg  Arg Leu Asn 
    1475                 1480                 1485             


Gln Glu  Val Ala Leu Asn Leu  Lys Glu Asp His Glu  Val Glu Val 
    1490                 1495                 1500             


Gly Val  Leu Lys Glu Ser Val  Asp Leu Pro Glu Glu  Lys Leu Pro 
    1505                 1510                 1515             


Ile Ser  Asp Ser Pro Pro Asp  Thr Gln Glu Ile His  Val Ile Glu 
    1520                 1525                 1530             


Gln Glu  Lys Leu Glu Ala Gln  Asp Ser Gly Glu Glu  Ala Arg Asn 
    1535                 1540                 1545             


Leu Ser  Phe Asn Glu Leu Tyr  Pro Ser Gly Thr Leu  Lys Leu Gln 
    1550                 1555                 1560             


Tyr Asn  Phe Asp Thr Ile Asp  Gln Gln Phe Cys Asp  Leu Ala Asp 
    1565                 1570                 1575             


Asn Lys  Asp Thr Ala Glu Cys  Asp Ile Ala Glu Val  Asp Gly Glu 
    1580                 1585                 1590             


Leu Phe  Val Ala Gln Ser Asn  Phe Thr Leu Ile Leu  Glu Gly Glu 
    1595                 1600                 1605             


Glu Gly  Glu Val Glu Pro Gly  Asp Phe Ala Ser Ser  Asp Val Leu 
    1610                 1615                 1620             


Pro Lys  Ala Ala Asn Thr Ala  Thr Glu Glu Lys Leu  Val Cys Ser 
    1625                 1630                 1635             


Gly Glu  Asn Asp Asn His Gly  Gln Ile Ala Asn Leu  Pro Ser Ala 
    1640                 1645                 1650             


Val Thr  Ser Asp Gln Lys Ser  Gln Lys Val Asp Thr  Leu Pro Tyr 
    1655                 1660                 1665             


Val Pro  Glu Pro Ile Lys Val  Ala Ile Ala Glu Asn  Leu Leu Asp 
    1670                 1675                 1680             


Val Ile  Lys Asp Thr Arg Ser  Lys Glu Ile Thr Ser  Asp Thr Met 
    1685                 1690                 1695             


Glu Gln  Ser Ile His Glu Thr  Ile Pro Leu Val Ser  Gln Asn Ile 
    1700                 1705                 1710             


Met Cys  Pro Thr Lys Leu Val  Lys Ser Ala Phe Lys  Thr Ala Gln 
    1715                 1720                 1725             


Glu Thr  Ser Thr Met Thr Met  Asn Val Ser Gln Val  Asp Asp Val 
    1730                 1735                 1740             


Val Ser  Ser Lys Thr Arg Thr  Arg Gly Gln Arg Ile  Gln Asn Val 
    1745                 1750                 1755             


Asn Val  Lys Ser Ala Gln Gln  Glu Ala Ser Ala Asp  Val Ala Thr 
    1760                 1765                 1770             


Pro Lys  Met Pro Gly Gln Ser  Val Arg Lys Lys Thr  Arg Lys Ala 
    1775                 1780                 1785             


Lys Glu  Ile Ser Glu Ala Ser  Glu Asn Ile Tyr Ser  Asp Val Arg 
    1790                 1795                 1800             


Gly Leu  Ser Gln Asn Gln Gln  Ile Pro Gln Asn Ser  Val Thr Pro 
    1805                 1810                 1815             


Arg Arg  Gly Arg Arg Lys Lys  Glu Val Asn Gln Asp  Ile Leu Glu 
    1820                 1825                 1830             


Asn Thr  Ser Ser Val Glu Gln  Glu Leu Gln Ile Thr  Thr Gly Arg 
    1835                 1840                 1845             


Glu Ser  Lys Arg Leu Lys Ser  Ser Gln Leu Leu Glu  Pro Ala Val 
    1850                 1855                 1860             


Glu Glu  Thr Thr Lys Lys Glu  Val Lys Val Ser Ser  Val Thr Lys 
    1865                 1870                 1875             


Arg Thr  Pro Arg Arg Ile Lys  Arg Ser Val Glu Asn  Gln Glu Ser 
    1880                 1885                 1890             


Val Glu  Ile Ile Asn Asp Leu  Lys Val Ser Thr Val  Thr Ser Pro 
    1895                 1900                 1905             


Ser Arg  Met Ile Arg Lys Leu  Arg Ser Thr Asn Leu  Asp Ala Ser 
    1910                 1915                 1920             


Glu Asn  Thr Gly Asn Lys Gln  Asp Asp Lys Ser Ser  Asp Lys Gln 
    1925                 1930                 1935             


Leu Arg  Ile Lys His Val Arg  Arg Val Arg Gly Arg  Glu Val Ser 
    1940                 1945                 1950             


Pro Ser  Asp Val Arg Glu Asp  Ser Asn Leu Glu Ser  Ser Gln Leu 
    1955                 1960                 1965             


Thr Val  Gln Ala Glu Phe Asp  Met Ser Ala Ile Pro  Arg Lys Arg 
    1970                 1975                 1980             


Gly Arg  Pro Arg Lys Ile Asn  Pro Ser Glu Asp Val  Gly Ser Lys 
    1985                 1990                 1995             


Ala Val  Lys Glu Glu Arg Ser  Pro Lys Lys Lys Glu  Ala Pro Ser 
    2000                 2005                 2010             


Ile Arg  Arg Arg Ser Thr Arg  Asn Thr Pro Ala Lys  Ser Glu Asn 
    2015                 2020                 2025             


Val Asp  Val Gly Lys Pro Ala  Leu Gly Lys Ser Ile  Leu Val Pro 
    2030                 2035                 2040             


Asn Glu  Glu Leu Ser Met Val  Met Ser Ser Lys Lys  Lys Leu Thr 
    2045                 2050                 2055             


Lys Lys  Thr Glu Ser Gln Ser  Gln Lys Arg Ser Leu  His Ser Val 
    2060                 2065                 2070             


Ser Glu  Glu Arg Thr Asp Glu  Met Thr His Lys Glu  Thr Asn Glu 
    2075                 2080                 2085             


Gln Glu  Glu Arg Leu Leu Ala  Thr Ala Ser Phe Thr  Lys Ser Ser 
    2090                 2095                 2100             


Arg Ser  Ser Arg Thr Arg Ser  Ser Lys Ala Ile Leu  Leu Pro Asp 
    2105                 2110                 2115             


Leu Ser  Glu Pro Asn Asn Glu  Pro Leu Phe Ser Pro  Ala Ser Glu 
    2120                 2125                 2130             


Val Pro  Arg Lys Ala Lys Ala  Lys Lys Ile Glu Val  Pro Ala Gln 
    2135                 2140                 2145             


Leu Lys  Glu Leu Val Ser Asp  Leu Ser Ser Gln Phe  Val Ile Ser 
    2150                 2155                 2160             


Pro Pro  Ala Leu Arg Ser Arg  Gln Lys Asn Thr Ser  Asn Lys Asn 
    2165                 2170                 2175             


Lys Leu  Glu Asp Glu Leu Lys  Asp Asp Ala Gln Ser  Val Glu Thr 
    2180                 2185                 2190             


Leu Gly  Lys Pro Lys Ala Lys  Arg Ile Arg Thr Ser  Lys Thr Lys 
    2195                 2200                 2205             


Gln Ala  Ser Lys Asn Thr Glu  Lys Glu Ser Ala Trp  Ser Pro Pro 
    2210                 2215                 2220             


Pro Ile  Glu Ile Arg Leu Ile  Ser Pro Leu Ala Ser  Pro Ala Asp 
    2225                 2230                 2235             


Gly Val  Lys Ser Lys Pro Arg  Lys Thr Thr Glu Val  Thr Gly Thr 
    2240                 2245                 2250             


Gly Leu  Gly Arg Asn Arg Lys  Lys Leu Ser Ser Tyr  Pro Lys Gln 
    2255                 2260                 2265             


Ile Leu  Arg Arg Lys Met Leu  
    2270                 2275 


<210>  1148
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  1148

Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu 
1               5                   10                  15      


Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys 
            20                  25                  30          


Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro 
        35                  40                  45              


Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile 
    50                  55                  60                  


Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly 
65                  70                  75                  80  


Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu 
                85                  90                  95      


Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro 
            100                 105                 110         


Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr 
        115                 120                 125             


Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr 
    130                 135                 140                 


Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala 
145                 150                 155                 160 


Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly 
                165                 170                 175     


Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe 
            180                 185                 190         


Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys 
        195                 200                 205             


Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys 
    210                 215                 220                 


Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe 
225                 230                 235                 240 


Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu 
                245                 250                 255     


Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn 
            260                 265                 270         


Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser 
        275                 280                 285             


His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala 
    290                 295                 300                 


Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu 
305                 310                 315             


<210>  1149
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  1149

Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Thr Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Thr Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Lys Lys Leu Pro Leu Thr Ala Leu Ala Gln Asn Met Gln Glu 
65                  70                  75                  80  


Ala Ser Thr Gln Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Thr 
                85                  90                  95      


Cys Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser Gln His Glu 
            100                 105                 110         


Val Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly Ile Ala Glu 
        115                 120                 125             


Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu Ala Arg Leu 
    130                 135                 140                 


Val Leu Asp Trp Asp Ser Val Arg Ala Arg Trp Asn Gln Ala His Lys 
145                 150                 155                 160 


Ser Ser Gly Thr Asn Phe Gln Gly Leu Pro Ser Lys Ile Asp Thr Leu 
                165                 170                 175     


Lys Glu Glu Met Asp Glu Ala Gly Asn Lys Val Glu Gln Cys Lys Asp 
            180                 185                 190         


Gln Leu Ala Ala Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr 
        195                 200                 205             


Gly Lys Phe Phe Val Thr Leu Leu Glu Ala Gln Ala Asp Tyr His Arg 
    210                 215                 220                 


Lys Ala Leu Ala Val Leu Glu Lys Thr Leu Pro Glu Met Arg Ala His 
225                 230                 235                 240 


Gln Asp Lys Trp Ala Glu Lys Pro Ala Phe Gly Thr Pro Leu Glu Glu 
                245                 250                 255     


His Leu Lys Arg Ser Gly Arg Glu Ile Ala Leu Pro Ile Glu Ala Cys 
            260                 265                 270         


Val Met Leu Leu Leu Glu Thr Gly Met Lys Glu Glu Gly Leu Phe Arg 
        275                 280                 285             


Ile Gly Ala Gly Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp 
    290                 295                 300                 


Cys Ser Thr Ser His Leu Asp Glu Phe Tyr Ser Asp Pro His Ala Val 
305                 310                 315                 320 


Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met 
                325                 330                 335     


Thr Phe Asn Leu Tyr Glu Glu Trp Thr Gln Val Ala Ser Val Gln Asp 
            340                 345                 350         


Gln Asp Lys Lys Leu Gln Asp Leu Trp Arg Thr Cys Gln Lys Leu Pro 
        355                 360                 365             


Pro Gln Asn Phe Val Asn Phe Arg Tyr Leu Ile Lys Phe Leu Ala Lys 
    370                 375                 380                 


Leu Ala Gln Thr Ser Asp Val Asn Lys Met Thr Pro Ser Asn Ile Ala 
385                 390                 395                 400 


Ile Val Leu Gly Pro Asn Leu Leu Trp Ala Arg Asn Glu Gly Thr Leu 
                405                 410                 415     


Ala Glu Met Ala Ala Ala Thr Ser Val His Val Val Ala Val Ile Glu 
            420                 425                 430         


Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Glu Glu Val Glu Phe 
        435                 440                 445             


Asn Val Ser Glu Ala Phe Val Pro Leu Thr Thr Pro Ser Ser Asn His 
    450                 455                 460                 


Ser Phe His Thr Gly Asn Asp Ser Asp Ser Gly Thr Leu Glu Arg Lys 
465                 470                 475                 480 


Arg Pro Ala Ser Met Ala Val Met Glu Gly Asp Leu Val Lys Lys Glu 
                485                 490                 495     


Ser Pro Pro Lys Pro Lys Asp Pro Val Ser Ala Ala Val Pro Ala Pro 
            500                 505                 510         


Gly Arg Asn Asn Ser Gln Ile Ala Ser Gly Gln Asn Gln Pro Gln Ala 
        515                 520                 525             


Ala Ala Gly Ser His Gln Leu Ser Met Gly Gln Pro His Asn Ala Ala 
    530                 535                 540                 


Gly Pro Ser Pro His Thr Leu Arg Arg Ala Val Lys Lys Pro Ala Pro 
545                 550                 555                 560 


Ala Pro Pro Lys Pro Gly Asn Pro Pro Pro Gly His Pro Gly Gly Gln 
                565                 570                 575     


Ser Ser Ser Gly Thr Ser Gln His Pro Pro Ser Leu Ser Pro Lys Pro 
            580                 585                 590         


Pro Thr Arg Ser Pro Ser Pro Pro Thr Gln His Thr Gly Gln Pro Pro 
        595                 600                 605             


Gly Gln Pro Ser Ala Pro Ser Gln Leu Ser Ala Pro Arg Arg Tyr Ser 
    610                 615                 620                 


Ser Ser Leu Ser Pro Ile Gln Ala Pro Asn His Pro Pro Pro Gln Pro 
625                 630                 635                 640 


Pro Thr Gln Ala Thr Pro Leu Met His Thr Lys Pro Asn Ser Gln Gly 
                645                 650                 655     


Pro Pro Asn Pro Met Ala Leu Pro Ser Glu His Gly Leu Glu Gln Pro 
            660                 665                 670         


Ser His Thr Pro Pro Gln Thr Pro Thr Pro Pro Ser Thr Pro Pro Leu 
        675                 680                 685             


Gly Lys Gln Asn Pro Ser Leu Pro Ala Pro Gln Thr Leu Ala Gly Gly 
    690                 695                 700                 


Asn Pro Glu Thr Ala Gln Pro His Ala Gly Thr Leu Pro Arg Pro Arg 
705                 710                 715                 720 


Pro Val Pro Lys Pro Arg Asn Arg Pro Ser Val Pro Pro Pro Pro Gln 
                725                 730                 735     


Pro Pro Gly Val His Ser Ala Gly Asp Ser Ser Leu Thr Asn Thr Ala 
            740                 745                 750         


Pro Thr Ala Ser Lys Ile Val Thr Asp Ser Asn Ser Arg Val Ser Glu 
        755                 760                 765             


Pro His Arg Ser Ile Phe Pro Glu Met His Ser Asp Ser Ala Ser Lys 
    770                 775                 780                 


Asp Val Pro Gly Arg Ile Leu Leu Asp Ile Asp Asn Asp Thr Glu Ser 
785                 790                 795                 800 


Thr Ala Leu 
            


<210>  1150
<211>  2285
<212>  PRT
<213>  Homo sapiens

<400>  1150

Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Asn 
    1355                 1360                 1365             


Tyr Lys  Arg Pro Met Asp Gly  Thr Tyr Gly Pro Pro  Ala Lys Arg 
    1370                 1375                 1380             


His Glu  Gly Glu Met Tyr Ser  Val Pro Tyr Ser Thr  Gly Gln Gly 
    1385                 1390                 1395             


Gln Pro  Gln Gln Gln Gln Leu  Pro Pro Ala Gln Pro  Gln Pro Ala 
    1400                 1405                 1410             


Ser Gln  Gln Gln Ala Ala Gln  Pro Ser Pro Gln Gln  Asp Val Tyr 
    1415                 1420                 1425             


Asn Gln  Tyr Gly Asn Ala Tyr  Pro Ala Thr Ala Thr  Ala Ala Thr 
    1430                 1435                 1440             


Glu Arg  Arg Pro Ala Gly Gly  Pro Gln Asn Gln Phe  Pro Phe Gln 
    1445                 1450                 1455             


Phe Gly  Arg Asp Arg Val Ser  Ala Pro Pro Gly Thr  Asn Ala Gln 
    1460                 1465                 1470             


Gln Asn  Met Pro Pro Gln Met  Met Gly Gly Pro Ile  Gln Ala Ser 
    1475                 1480                 1485             


Ala Glu  Val Ala Gln Gln Gly  Thr Met Trp Gln Gly  Arg Asn Asp 
    1490                 1495                 1500             


Met Thr  Tyr Asn Tyr Ala Asn  Arg Gln Ser Thr Gly  Ser Ala Pro 
    1505                 1510                 1515             


Gln Gly  Pro Ala Tyr His Gly  Val Asn Arg Thr Asp  Glu Met Leu 
    1520                 1525                 1530             


His Thr  Asp Gln Arg Ala Asn  His Glu Gly Ser Trp  Pro Ser His 
    1535                 1540                 1545             


Gly Thr  Arg Gln Pro Pro Tyr  Gly Pro Ser Ala Pro  Val Pro Pro 
    1550                 1555                 1560             


Met Thr  Arg Pro Pro Pro Ser  Asn Tyr Gln Pro Pro  Pro Ser Met 
    1565                 1570                 1575             


Gln Asn  His Ile Pro Gln Val  Ser Ser Pro Ala Pro  Leu Pro Arg 
    1580                 1585                 1590             


Pro Met  Glu Asn Arg Thr Ser  Pro Ser Lys Ser Pro  Phe Leu His 
    1595                 1600                 1605             


Ser Gly  Met Lys Met Gln Lys  Ala Gly Pro Pro Val  Pro Ala Ser 
    1610                 1615                 1620             


His Ile  Ala Pro Ala Pro Val  Gln Pro Pro Met Ile  Arg Arg Asp 
    1625                 1630                 1635             


Ile Thr  Phe Pro Pro Gly Ser  Val Glu Ala Thr Gln  Pro Val Leu 
    1640                 1645                 1650             


Lys Gln  Arg Arg Arg Leu Thr  Met Lys Asp Ile Gly  Thr Pro Glu 
    1655                 1660                 1665             


Ala Trp  Arg Val Met Met Ser  Leu Lys Ser Gly Leu  Leu Ala Glu 
    1670                 1675                 1680             


Ser Thr  Trp Ala Leu Asp Thr  Ile Asn Ile Leu Leu  Tyr Asp Asp 
    1685                 1690                 1695             


Asn Ser  Ile Met Thr Phe Asn  Leu Ser Gln Leu Pro  Gly Leu Leu 
    1700                 1705                 1710             


Glu Leu  Leu Val Glu Tyr Phe  Arg Arg Cys Leu Ile  Glu Ile Phe 
    1715                 1720                 1725             


Gly Ile  Leu Lys Glu Tyr Glu  Val Gly Asp Pro Gly  Gln Arg Thr 
    1730                 1735                 1740             


Leu Leu  Asp Pro Gly Arg Phe  Ser Lys Val Ser Ser  Pro Ala Pro 
    1745                 1750                 1755             


Met Glu  Gly Gly Glu Glu Glu  Glu Glu Leu Leu Gly  Pro Lys Leu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Glu Glu  Val Val Glu Asn Asp  Glu Glu Ile 
    1775                 1780                 1785             


Ala Phe  Ser Gly Lys Asp Lys  Pro Ala Ser Glu Asn  Ser Glu Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ser Lys Phe Asp  Lys Leu Pro Val Lys  Ile Val Gln 
    1805                 1810                 1815             


Lys Asn  Asp Pro Phe Val Val  Asp Cys Ser Asp Lys  Leu Gly Arg 
    1820                 1825                 1830             


Val Gln  Glu Phe Asp Ser Gly  Leu Leu His Trp Arg  Ile Gly Gly 
    1835                 1840                 1845             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Thr 
    1850                 1855                 1860             


Glu Leu  Leu Pro Ser Arg Pro  His Ala Pro Cys Pro  Pro Ala Pro 
    1865                 1870                 1875             


Arg Lys  His Val Thr Thr Ala  Glu Gly Thr Pro Gly  Thr Thr Asp 
    1880                 1885                 1890             


Gln Glu  Gly Pro Pro Pro Asp  Gly Pro Pro Glu Lys  Arg Ile Thr 
    1895                 1900                 1905             


Ala Thr  Met Asp Asp Met Leu  Ser Thr Arg Ser Ser  Thr Leu Thr 
    1910                 1915                 1920             


Glu Asp  Gly Ala Lys Ser Ser  Glu Ala Ile Lys Glu  Ser Ser Lys 
    1925                 1930                 1935             


Phe Pro  Phe Gly Ile Ser Pro  Ala Gln Ser His Arg  Asn Ile Lys 
    1940                 1945                 1950             


Ile Leu  Glu Asp Glu Pro His  Ser Lys Asp Glu Thr  Pro Leu Cys 
    1955                 1960                 1965             


Thr Leu  Leu Asp Trp Gln Asp  Ser Leu Ala Lys Arg  Cys Val Cys 
    1970                 1975                 1980             


Val Ser  Asn Thr Ile Arg Ser  Leu Ser Phe Val Pro  Gly Asn Asp 
    1985                 1990                 1995             


Phe Glu  Met Ser Lys His Pro  Gly Leu Leu Leu Ile  Leu Gly Lys 
    2000                 2005                 2010             


Leu Ile  Leu Leu His His Lys  His Pro Glu Arg Lys  Gln Ala Pro 
    2015                 2020                 2025             


Leu Thr  Tyr Glu Lys Glu Glu  Glu Gln Asp Gln Gly  Val Ser Cys 
    2030                 2035                 2040             


Asn Lys  Val Glu Trp Trp Trp  Asp Cys Leu Glu Met  Leu Arg Glu 
    2045                 2050                 2055             


Asn Thr  Leu Val Thr Leu Ala  Asn Ile Ser Gly Gln  Leu Asp Leu 
    2060                 2065                 2070             


Ser Pro  Tyr Pro Glu Ser Ile  Cys Leu Pro Val Leu  Asp Gly Leu 
    2075                 2080                 2085             


Leu His  Trp Ala Val Cys Pro  Ser Ala Glu Ala Gln  Asp Pro Phe 
    2090                 2095                 2100             


Ser Thr  Leu Gly Pro Asn Ala  Val Leu Ser Pro Gln  Arg Leu Val 
    2105                 2110                 2115             


Leu Glu  Thr Leu Ser Lys Leu  Ser Ile Gln Asp Asn  Asn Val Asp 
    2120                 2125                 2130             


Leu Ile  Leu Ala Thr Pro Pro  Phe Ser Arg Leu Glu  Lys Leu Tyr 
    2135                 2140                 2145             


Ser Thr  Met Val Arg Phe Leu  Ser Asp Arg Lys Asn  Pro Val Cys 
    2150                 2155                 2160             


Arg Glu  Met Ala Val Val Leu  Leu Ala Asn Leu Ala  Gln Gly Asp 
    2165                 2170                 2175             


Ser Leu  Ala Ala Arg Ala Ile  Ala Val Gln Lys Gly  Ser Ile Gly 
    2180                 2185                 2190             


Asn Leu  Leu Gly Phe Leu Glu  Asp Ser Leu Ala Ala  Thr Gln Phe 
    2195                 2200                 2205             


Gln Gln  Ser Gln Ala Ser Leu  Leu His Met Gln Asn  Pro Pro Phe 
    2210                 2215                 2220             


Glu Pro  Thr Ser Val Asp Met  Met Arg Arg Ala Ala  Arg Ala Leu 
    2225                 2230                 2235             


Leu Ala  Leu Ala Lys Val Asp  Glu Asn His Ser Glu  Phe Thr Leu 
    2240                 2245                 2250             


Tyr Glu  Ser Arg Leu Leu Asp  Ile Ser Val Ser Pro  Leu Met Asn 
    2255                 2260                 2265             


Ser Leu  Val Ser Gln Val Ile  Cys Asp Val Leu Phe  Leu Ile Gly 
    2270                 2275                 2280             


Gln Ser  
    2285 


<210>  1151
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  1151

Met Ser Val Asp Met Asn Ser Gln Gly Ser Asp Ser Asn Glu Glu Asp 
1               5                   10                  15      


Tyr Asp Pro Asn Cys Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Pro 
            20                  25                  30          


Gly Asp Ile Glu Asp Tyr Tyr Val Gly Val Ala Ser Asp Val Glu Gln 
        35                  40                  45              


Gln Gly Ala Asp Ala Phe Asp Pro Glu Glu Tyr Gln Phe Thr Cys Leu 
    50                  55                  60                  


Thr Tyr Lys Glu Ser Glu Gly Ala Leu Asn Glu His Met Thr Ser Leu 
65                  70                  75                  80  


Ala Ser Val Leu Lys Val Ser His Ser Val Ala Lys Leu Ile Leu Val 
                85                  90                  95      


Asn Phe His Trp Gln Val Ser Glu Ile Leu Asp Arg Tyr Lys Ser Asn 
            100                 105                 110         


Ser Ala Gln Leu Leu Val Glu Ala Arg Val Gln Pro Asn Pro Ser Lys 
        115                 120                 125             


His Val Pro Thr Ser His Pro Pro His His Cys Ala Val Cys Met Gln 
    130                 135                 140                 


Phe Val Arg Lys Glu Asn Leu Leu Ser Leu Ala Cys Gln His Gln Phe 
145                 150                 155                 160 


Cys Arg Ser Cys Trp Glu Gln His Cys Ser Val Leu Val Lys Asp Gly 
                165                 170                 175     


Val Gly Val Gly Val Ser Cys Met Ala Gln Asp Cys Pro Leu Arg Thr 
            180                 185                 190         


Pro Glu Asp Phe Val Phe Pro Leu Leu Pro Asn Glu Glu Leu Arg Glu 
        195                 200                 205             


Lys Tyr Arg Arg Tyr Leu Phe Arg Asp Tyr Val Glu Ser His Tyr Gln 
    210                 215                 220                 


Leu Gln Leu Cys Pro Gly Ala Asp Cys Pro Met Val Ile Arg Val Gln 
225                 230                 235                 240 


Glu Pro Arg Ala Arg Arg Val Gln Cys Asn Arg Cys Asn Glu Val Phe 
                245                 250                 255     


Cys Phe Lys Cys Arg Gln Met Tyr His Ala Pro Thr Asp Cys Ala Thr 
            260                 265                 270         


Ile Arg Lys Trp Leu Thr Lys Cys Ala Asp Asp Ser Glu Thr Ala Asn 
        275                 280                 285             


Tyr Ile Ser Ala His Thr Lys Asp Cys Pro Lys Cys Asn Ile Cys Ile 
    290                 295                 300                 


Glu Lys Asn Gly Gly Cys Asn His Met Gln Cys Ser Lys Cys Lys His 
305                 310                 315                 320 


Asp Phe Cys Trp Met Cys Leu Gly Asp Trp Lys Thr His Gly Ser Glu 
                325                 330                 335     


Tyr Tyr Glu Cys Ser Arg Tyr Lys Glu Asn Pro Asp Ile Val Asn Gln 
            340                 345                 350         


Ser Gln Gln Ala Gln Ala Arg Glu Ala Leu Lys Lys Tyr Leu Phe Tyr 
        355                 360                 365             


Phe Glu Arg Trp Glu Asn His Asn Lys Ser Leu Gln Leu Glu Ala Gln 
    370                 375                 380                 


Thr Tyr Gln Arg Ile His Glu Lys Ile Gln Glu Arg Val Met Asn Asn 
385                 390                 395                 400 


Leu Gly Thr Trp Ile Asp Trp Gln Tyr Leu Gln Asn Ala Ala Lys Leu 
                405                 410                 415     


Leu Ala Lys Cys Arg Tyr Thr Leu Gln Tyr Thr Tyr Pro Tyr Ala Tyr 
            420                 425                 430         


Tyr Met Glu Ser Gly Pro Arg Lys Lys Leu Phe Glu Tyr Gln Gln Ala 
        435                 440                 445             


Gln Leu Glu Ala Glu Ile Glu Asn Leu Ser Trp Lys Val Glu Arg Ala 
    450                 455                 460                 


Asp Ser Tyr Asp Arg Gly Asp Leu Glu Asn Gln Met His Ile Ala Glu 
465                 470                 475                 480 


Gln Arg Arg Arg Thr Leu Leu Lys Asp Phe His Asp Thr 
                485                 490             


<210>  1152
<211>  1435
<212>  PRT
<213>  Homo sapiens

<400>  1152

Met Arg Glu Lys Gly Arg Arg Lys Lys Gly Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Lys Thr Val Leu Glu Lys Tyr Pro Asn Thr Pro Met Ser His Lys 
            20                  25                  30          


Glu Ile Leu Gln Val Ile Gln Arg Glu Gly Leu Lys Glu Ile Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Thr Asn Ser 
    50                  55                  60                  


Arg Gly Glu Glu Gly Ile Phe Tyr Lys Val Pro Gly Arg Met Gly Val 
65                  70                  75                  80  


Tyr Thr Leu Lys Lys Asp Val Pro Asp Gly Val Lys Glu Leu Ser Glu 
                85                  90                  95      


Gly Ser Glu Glu Ser Ser Asp Gly Gln Ser Asp Ser Gln Ser Ser Glu 
            100                 105                 110         


Asn Ser Ser Ser Ser Ser Asp Gly Gly Ser Asn Lys Glu Gly Lys Lys 
        115                 120                 125             


Ser Arg Trp Lys Arg Lys Val Ser Ser Ser Ser Pro Gln Ser Gly Cys 
    130                 135                 140                 


Pro Ser Pro Thr Ile Pro Ala Gly Lys Val Ile Ser Pro Ser Gln Lys 
145                 150                 155                 160 


His Ser Lys Lys Ala Leu Lys Gln Ala Leu Lys Gln Gln Gln Gln Lys 
                165                 170                 175     


Lys Gln Gln Gln Gln Cys Arg Pro Ser Ile Ser Ile Ser Ser Asn Gln 
            180                 185                 190         


His Leu Ser Leu Lys Thr Val Lys Ala Ala Ser Asp Ser Val Pro Ala 
        195                 200                 205             


Lys Pro Ala Thr Trp Glu Gly Lys Gln Ser Asp Gly Gln Thr Gly Ser 
    210                 215                 220                 


Pro Gln Asn Ser Asn Ser Ser Phe Ser Ser Ser Val Lys Val Glu Asn 
225                 230                 235                 240 


Thr Leu Leu Gly Leu Gly Lys Lys Ser Phe Gln Arg Ser Glu Arg Leu 
                245                 250                 255     


His Thr Arg Gln Met Lys Arg Thr Lys Cys Ala Asp Ile Asp Val Glu 
            260                 265                 270         


Thr Pro Asp Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn 
        275                 280                 285             


Lys His Thr Phe Ser Val Leu Pro Gly Asp Cys Gln Gln Arg Leu Leu 
    290                 295                 300                 


Leu Leu Leu Pro Glu Val Asp Arg Gln Val Gly Pro Asp Gly Leu Met 
305                 310                 315                 320 


Lys Leu Asn Gly Ser Ala Leu Asn Asn Glu Phe Phe Thr Ser Ala Ala 
                325                 330                 335     


Gln Gly Trp Lys Glu Arg Leu Ser Glu Gly Glu Phe Thr Pro Glu Met 
            340                 345                 350         


Gln Val Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys Lys Val Glu Pro 
        355                 360                 365             


Trp Lys Glu Gln Phe Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu 
    370                 375                 380                 


Ser Leu Glu Asp Ser Lys Lys Leu Thr Ala Ser Pro Ser Asp Pro Lys 
385                 390                 395                 400 


Val Lys Lys Thr Pro Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu 
                405                 410                 415     


Ala Ser Leu Ile Arg Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys 
            420                 425                 430         


Glu Glu Ala Leu Gln Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu 
        435                 440                 445             


Ser Gln Gly Glu Val Gln Pro Asn Phe Ser Thr Ser Ser Glu Pro Leu 
    450                 455                 460                 


Leu Ser Ser Ala Leu Asn Thr His Glu Leu Ser Ser Ile Leu Pro Ile 
465                 470                 475                 480 


Lys Cys Pro Lys Asp Glu Asp Leu Leu Glu Gln Lys Pro Val Thr Ser 
                485                 490                 495     


Ala Glu Gln Glu Ser Glu Lys Asn His Leu Thr Thr Ala Ser Asn Tyr 
            500                 505                 510         


Asn Lys Ser Glu Ser Gln Glu Ser Leu Val Thr Ser Pro Ser Lys Pro 
        515                 520                 525             


Lys Ser Pro Gly Val Glu Lys Pro Ile Val Lys Pro Thr Ala Gly Ala 
    530                 535                 540                 


Gly Pro Gln Glu Thr Asn Met Lys Glu Pro Leu Ala Thr Leu Val Asp 
545                 550                 555                 560 


Gln Ser Pro Glu Ser Leu Lys Arg Lys Ser Ser Leu Thr Gln Glu Glu 
                565                 570                 575     


Ala Pro Val Ser Trp Glu Lys Arg Pro Arg Val Thr Glu Asn Arg Gln 
            580                 585                 590         


His Gln Gln Pro Phe Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly 
        595                 600                 605             


Asp Arg Ile Gln Val Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser 
    610                 615                 620                 


Arg Ile Ser Pro Met Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala 
625                 630                 635                 640 


Arg Phe Pro Val Ser Ile Thr Ser Pro Asn Arg Thr Gly Ala Arg Thr 
                645                 650                 655     


Leu Ala Asp Ile Lys Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala 
            660                 665                 670         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly 
        675                 680                 685             


Thr Ile Pro Gly Pro Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly 
    690                 695                 700                 


Gly Glu Gly Gln Thr Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val 
705                 710                 715                 720 


Ser Glu Thr Gly Lys Gly Pro Thr Leu Glu Leu Ala Gly Thr Gly Ser 
                725                 730                 735     


Arg Gly Gly Thr Arg Glu Leu Leu Pro Cys Gly Pro Glu Thr Gln Pro 
            740                 745                 750         


Gln Ser Glu Thr Lys Thr Thr Pro Ser Gln Ala Gln Pro His Ser Val 
        755                 760                 765             


Ser Gly Ala Gln Leu Gln Gln Thr Pro Pro Val Pro Pro Thr Pro Ala 
    770                 775                 780                 


Val Ser Gly Ala Cys Thr Ser Val Pro Ser Pro Ala His Ile Glu Lys 
785                 790                 795                 800 


Leu Asp Asn Glu Lys Leu Asn Pro Thr Arg Ala Thr Ala Thr Val Ala 
                805                 810                 815     


Ser Val Ser His Pro Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala 
            820                 825                 830         


Pro Ser Pro Thr Gly Pro Ala Leu Ile Ser Gly Ala Ser Pro Val His 
        835                 840                 845             


Cys Ala Ala Asp Gly Thr Val Glu Leu Lys Ala Gly Pro Ser Lys Asn 
    850                 855                 860                 


Ile Pro Asn Pro Ser Ala Ser Ser Lys Thr Asp Ala Ser Val Pro Val 
865                 870                 875                 880 


Ala Val Thr Pro Ser Pro Leu Thr Ser Leu Leu Thr Thr Ala Thr Leu 
                885                 890                 895     


Glu Lys Leu Pro Val Pro Gln Val Ser Ala Thr Thr Ala Pro Ala Gly 
            900                 905                 910         


Ser Ala Pro Pro Ser Ser Thr Leu Pro Ala Ala Ser Ser Leu Lys Thr 
        915                 920                 925             


Pro Gly Thr Ser Leu Asn Met Asn Gly Pro Thr Leu Arg Pro Thr Ser 
    930                 935                 940                 


Ser Ile Pro Ala Asn Asn Pro Leu Val Thr Gln Leu Leu Gln Gly Lys 
945                 950                 955                 960 


Asp Val Pro Met Glu Gln Ile Leu Pro Lys Pro Leu Thr Lys Val Glu 
                965                 970                 975     


Met Lys Thr Val Pro Leu Thr Ala Lys Glu Glu Arg Gly Met Gly Ala 
            980                 985                 990         


Leu Ile Ala Thr Asn Thr Thr Glu  Asn Ser Thr Arg Glu  Glu Val Asn 
        995                 1000                 1005             


Glu Arg  Gln Ser His Pro Ala  Thr Gln Gln Gln Leu  Gly Lys Thr 
    1010                 1015                 1020             


Leu Gln  Ser Lys Gln Leu Pro  Gln Val Pro Arg Pro  Leu Gln Leu 
    1025                 1030                 1035             


Phe Ser  Ala Lys Glu Leu Arg  Asp Ser Ser Ile Asp  Thr His Gln 
    1040                 1045                 1050             


Tyr His  Glu Gly Leu Ser Lys  Ala Thr Gln Asp Gln  Ile Leu Gln 
    1055                 1060                 1065             


Thr Leu  Ile Gln Arg Val Arg  Arg Gln Asn Leu Leu  Ser Val Val 
    1070                 1075                 1080             


Pro Pro  Ser Gln Phe Asn Phe  Ala His Ser Gly Phe  Gln Leu Glu 
    1085                 1090                 1095             


Asp Ile  Ser Thr Ser Gln Arg  Phe Met Leu Gly Phe  Ala Gly Arg 
    1100                 1105                 1110             


Arg Thr  Ser Lys Pro Ala Met  Ala Gly His Tyr Leu  Leu Asn Ile 
    1115                 1120                 1125             


Ser Thr  Tyr Gly Arg Gly Ser  Glu Ser Phe Arg Arg  Thr His Ser 
    1130                 1135                 1140             


Val Asn  Pro Glu Asp Arg Phe  Cys Leu Ser Ser Pro  Thr Glu Ala 
    1145                 1150                 1155             


Leu Lys  Met Gly Tyr Thr Asp  Cys Lys Asn Ala Thr  Gly Glu Ser 
    1160                 1165                 1170             


Ser Ser  Ser Lys Glu Asp Asp  Thr Asp Glu Glu Ser  Thr Gly Asp 
    1175                 1180                 1185             


Glu Gln  Glu Ser Val Thr Val  Lys Glu Glu Pro Gln  Val Ser Gln 
    1190                 1195                 1200             


Ser Ala  Gly Lys Gly Asp Thr  Ser Ser Gly Pro His  Ser Arg Glu 
    1205                 1210                 1215             


Thr Leu  Ser Thr Ser Asp Cys  Leu Ala Ser Lys Asn  Val Lys Ala 
    1220                 1225                 1230             


Glu Ile  Pro Leu Asn Glu Gln  Thr Thr Leu Ser Lys  Glu Asn Tyr 
    1235                 1240                 1245             


Leu Phe  Thr Arg Gly Gln Thr  Phe Asp Glu Lys Thr  Leu Ala Arg 
    1250                 1255                 1260             


Asp Leu  Ile Gln Ala Ala Gln  Lys Gln Met Ala His  Ala Val Arg 
    1265                 1270                 1275             


Gly Lys  Ala Ile Arg Ser Ser  Pro Glu Leu Phe Ser  Ser Thr Val 
    1280                 1285                 1290             


Leu Pro  Leu Pro Ala Asp Ser  Pro Thr His Gln Pro  Leu Leu Leu 
    1295                 1300                 1305             


Pro Pro  Leu Gln Thr Pro Lys  Leu Tyr Gly Ser Pro  Thr Gln Ile 
    1310                 1315                 1320             


Gly Pro  Ser Tyr Arg Gly Met  Ile Asn Val Ser Thr  Ser Ser Asp 
    1325                 1330                 1335             


Met Asp  His Asn Ser Ala Val  Pro Gly Ser Gln Val  Ser Ser Asn 
    1340                 1345                 1350             


Val Gly  Asp Val Met Ser Phe  Ser Val Thr Val Thr  Thr Ile Pro 
    1355                 1360                 1365             


Ala Ser  Gln Ala Met Asn Pro  Ser Ser His Gly Gln  Thr Ile Pro 
    1370                 1375                 1380             


Val Gln  Ala Phe Ser Glu Glu  Asn Ser Ile Glu Gly  Thr Pro Ser 
    1385                 1390                 1395             


Lys Cys  Tyr Cys Arg Leu Lys  Ala Met Ile Met Cys  Lys Gly Cys 
    1400                 1405                 1410             


Gly Ala  Phe Cys His Asp Asp  Cys Ile Gly Pro Ser  Lys Leu Cys 
    1415                 1420                 1425             


Val Ser  Cys Leu Val Val Arg  
    1430                 1435 


<210>  1153
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  1153

Met Pro Lys His Glu Phe Ser Val Asp Met Thr Cys Gly Gly Cys Ala 
1               5                   10                  15      


Glu Ala Val Ser Arg Val Leu Asn Lys Leu Gly Gly Val Lys Tyr Asp 
            20                  25                  30          


Ile Asp Leu Pro Asn Lys Lys Val Cys Ile Glu Ser Glu His Ser Met 
        35                  40                  45              


Asp Thr Leu Leu Ala Thr Leu Lys Lys Thr Gly Lys Thr Val Ser Tyr 
    50                  55                  60                  


Leu Gly Leu Glu 
65              


<210>  1154
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  1154

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  1155
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  1155

Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
1               5                   10                  15      


Leu Pro Val Pro Thr Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
            20                  25                  30          


Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Thr Tyr Lys 
        35                  40                  45              


Thr Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
    50                  55                  60                  


Phe Pro Arg Tyr Ala Glu Ile Val His Leu Thr Leu Pro Asp Gly Thr 
65                  70                  75                  80  


Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                85                  90                  95      


Gln Val Phe Glu Gly Thr Ser Gly Ile Asp Ala Lys Lys Thr Ser Cys 
            100                 105                 110         


Glu Phe Thr Gly Asp Ile Leu Arg Thr Pro Val Ser Glu Asp Met Leu 
        115                 120                 125             


Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
    130                 135                 140                 


Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
145                 150                 155                 160 


Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Thr Gly Ile Ser Ala 
                165                 170                 175     


Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
            180                 185                 190         


Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
        195                 200                 205             


Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
    210                 215                 220                 


Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Thr 
225                 230                 235                 240 


Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                245                 250                 255     


Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile 
            260                 265                 270         


Ile Thr Pro Arg Leu Ala Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln 
        275                 280                 285             


Cys Glu Lys His Val Leu Val Ile Leu Thr Asp Met Ser Ser Tyr Ala 
    290                 295                 300                 


Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
305                 310                 315                 320 


Arg Gly Phe Pro Gly Tyr Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu 
                325                 330                 335     


Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Thr Gln Ile Pro 
            340                 345                 350         


Ile Leu Thr Met Pro Asn Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
        355                 360                 365             


Thr Gly Tyr Ile Thr Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
    370                 375                 380                 


Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
385                 390                 395                 400 


Leu Met Lys Ser Ala Ile Gly Glu Gly Met Thr Arg Lys Asp His Ala 
                405                 410                 415     


Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
            420                 425                 430         


Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Thr Ser Asp Asp 
        435                 440                 445             


Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile Ala 
    450                 455                 460                 


Gln Gly Pro Tyr Glu Asn Arg Thr Val Phe Glu Thr Leu Asp Ile Gly 
465                 470                 475                 480 


Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                485                 490                 495     


Gln Ser Thr Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
            500                 505                 510     


<210>  1156
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  1156

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg 
            740                 745                 750         


Ser Thr Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210>  1157
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  1157

Met Pro Arg Cys Pro Ala Gly Ala Met Asp Glu Gly Pro Val Asp Leu 
1               5                   10                  15      


Arg Thr Arg Pro Lys Ala Ala Gly Leu Pro Gly Ala Ala Leu Pro Leu 
            20                  25                  30          


Arg Lys Arg Pro Leu Arg Ala Pro Ser Pro Glu Pro Ala Ala Pro Arg 
        35                  40                  45              


Gly Ala Ala Gly Leu Val Val Pro Leu Asp Pro Leu Arg Gly Gly Cys 
    50                  55                  60                  


Asp Leu Pro Ala Val Pro Gly Pro Pro His Gly Leu Ala Arg Pro Glu 
65                  70                  75                  80  


Ala Leu Tyr Tyr Pro Gly Ala Leu Leu Pro Leu Tyr Pro Thr Arg Ala 
                85                  90                  95      


Met Gly Ser Pro Phe Pro Leu Val Asn Leu Pro Thr Pro Leu Tyr Pro 
            100                 105                 110         


Met Met Cys Pro Met Glu His Pro Leu Ser Ala Asp Ile Ala Met Ala 
        115                 120                 125             


Thr Arg Ala Asp Glu Asp Gly Asp Thr Pro Leu His Ile Ala Val Val 
    130                 135                 140                 


Gln Gly Asn Leu Pro Ala Val His Arg Leu Val Asn Leu Phe Gln Gln 
145                 150                 155                 160 


Gly Gly Arg Glu Leu Asp Ile Tyr Asn Asn Leu Arg Gln Thr Pro Leu 
                165                 170                 175     


His Leu Ala Val Ile Thr Thr Leu Pro Ser Val Val Arg Leu Leu Val 
            180                 185                 190         


Thr Ala Gly Ala Ser Pro Met Ala Leu Asp Arg His Gly Gln Thr Ala 
        195                 200                 205             


Ala His Leu Ala Cys Glu His Arg Ser Pro Thr Cys Leu Arg Ala Leu 
    210                 215                 220                 


Leu Asp Ser Ala Ala Pro Gly Thr Leu Asp Leu Glu Ala Arg Asn Tyr 
225                 230                 235                 240 


Asp Gly Leu Thr Ala Leu His Val Ala Val Asn Thr Glu Cys Gln Glu 
                245                 250                 255     


Thr Val Gln Leu Leu Leu Glu Arg Gly Ala Asp Ile Asp Ala Val Asp 
            260                 265                 270         


Ile Lys Ser Gly Arg Ser Pro Leu Ile His Ala Val Glu Asn Asn Ser 
        275                 280                 285             


Leu Ser Met Val Gln Leu Leu Leu Gln His Gly Ala Asn Val Asn Ala 
    290                 295                 300                 


Gln Met Tyr Ser Gly Ser Ser Ala Leu His Ser Ala Ser Gly Arg Gly 
305                 310                 315                 320 


Leu Leu Pro Leu Val Arg Thr Leu Val Arg Ser Gly Ala Asp Ser Ser 
                325                 330                 335     


Leu Lys Asn Cys His Asn Asp Thr Pro Leu Met Val Ala Arg Ser Arg 
            340                 345                 350         


Arg Val Ile Asp Ile Leu Arg Gly Lys Ala Thr Arg Pro Ala Ser Thr 
        355                 360                 365             


Ser Gln Pro Asp Pro Ser Pro Asp Arg Ser Ala Asn Thr Ser Pro Glu 
    370                 375                 380                 


Ser Ser Ser Arg Leu Ser Ser Asn Gly Leu Leu Ser Ala Ser Pro Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Gln Ser Pro Pro Arg Asp Pro Pro Gly Phe Pro Met 
                405                 410                 415     


Ala Pro Pro Asn Phe Phe Leu Pro Ser Pro Ser Pro Pro Ala Phe Leu 
            420                 425                 430         


Pro Phe Ala Gly Val Leu Arg Gly Pro Gly Arg Pro Val Pro Pro Ser 
        435                 440                 445             


Pro Ala Pro Gly Gly Ser 
    450                 


<210>  1158
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  1158

Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His 
            580                 585                 590         


Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys 
705     


<210>  1159
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  1159

Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 
    210                 215                 220                 


Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 
                325                 330                 335     


Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 
    450                 455                 460                 


Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 
465                 470                 475                 480 


Thr Val 
        


<210>  1160
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  1160

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Glu Pro Gln Thr Thr Val 
                325                 330                 335     


Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
            340                 345                 350         


Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
        355                 360                 365             


Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
    370                 375                 380                 


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
385                 390                 395                 400 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
                405                 410                 415     


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
            420                 425                 430         


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
        435                 440                 445             


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
    450                 455                 460                 


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
465                 470                 475                 480 


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
                485                 490                 495 


<210>  1161
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  1161

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                85                  90                  95      


Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
            100                 105                 110         


Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
    130                 135                 140                 


Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
145                 150                 155                 160 


Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                165                 170                 175     


Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
        195                 200                 205             


Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
    210                 215                 220                 


Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
225                 230                 235                 240 


Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                245                 250                 255     


Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
            260                 265                 270         


Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
        275                 280                 285             


Ala Ile His Leu 
    290         


<210>  1162
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  1162

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  1163
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1163

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Asn Ile Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  1164
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  1164

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  1165
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  1165

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  1166
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1166

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210>  1167
<211>  2537
<212>  PRT
<213>  Homo sapiens

<400>  1167

Met Glu Asp Phe Arg Gly Ile Ala Glu Glu Ser Phe Pro Ser Phe Leu 
1               5                   10                  15      


Thr Asn Ser Leu Phe Gly Asn Ser Gly Ile Leu Glu Asn Val Thr Leu 
            20                  25                  30          


Ser Ser Asn Leu Gly Leu Pro Val Ala Val Ser Thr Leu Ala Arg Asp 
        35                  40                  45              


Arg Ser Ser Thr Asp Asn Arg Tyr Pro Asp Ile Gln Ala Ser Tyr Leu 
    50                  55                  60                  


Val Glu Gly Arg Phe Ser Val Pro Ser Gly Ser Ser Pro Gly Ser Gln 
65                  70                  75                  80  


Ser Asp Ala Glu Pro Arg Glu Arg Leu Gln Leu Ser Phe Gln Asp Asp 
                85                  90                  95      


Asp Ser Ile Ser Arg Lys Lys Ser Tyr Val Glu Ser Gln Arg Leu Ser 
            100                 105                 110         


Asn Ala Leu Ser Lys Gln Ser Ala Leu Gln Met Glu Thr Ala Gly Pro 
        115                 120                 125             


Glu Glu Glu Pro Ala Gly Ala Thr Glu Ser Leu Gln Gly Gln Asp Leu 
    130                 135                 140                 


Phe Asn Arg Ala Ser Pro Leu Glu Gln Ala Gln Asp Ser Pro Ile Asp 
145                 150                 155                 160 


Phe His Leu Gln Ser Trp Met Asn Asn Lys Glu Pro Lys Ile Val Val 
                165                 170                 175     


Leu Asp Ala Gly Lys His Phe Glu Asp Lys Thr Leu Lys Ser Asp Leu 
            180                 185                 190         


Ser His Thr Ser Leu Leu Glu Asn Glu Lys Leu Ile Leu Pro Thr Ser 
        195                 200                 205             


Leu Glu Asp Ser Ser Asp Asp Asp Ile Asp Asp Glu Met Phe Tyr Asp 
    210                 215                 220                 


Asp His Leu Glu Ala Tyr Phe Glu Gln Leu Ala Ile Pro Gly Met Ile 
225                 230                 235                 240 


Tyr Glu Asp Leu Glu Gly Pro Glu Pro Pro Glu Lys Gly Phe Lys Leu 
                245                 250                 255     


Pro Thr Asn Gly Leu Arg Gln Ala Asn Glu Asn Gly Ser Leu Asn Cys 
            260                 265                 270         


Lys Phe Gln Ser Glu Asn Asn Ser Ser Leu Ile Ser Leu Asp Ser His 
        275                 280                 285             


Ser Ser Glu Thr Thr His Lys Glu Ser Glu Glu Ser Gln Val Ile Cys 
    290                 295                 300                 


Leu Pro Gly Thr Ser Asn Ser Ile Gly Thr Gly Asp Ser Arg Arg Tyr 
305                 310                 315                 320 


Thr Asp Gly Met Leu Pro Phe Ser Ser Gly Thr Trp Gly Thr Glu Lys 
                325                 330                 335     


Glu Ile Glu Asn Leu Lys Gly Ile Val Pro Asp Leu Asn Ser Glu Cys 
            340                 345                 350         


Ala Ser Lys Asp Val Leu Val Lys Thr Leu Arg Ala Ile Asp Val Lys 
        355                 360                 365             


Leu Asn Ser Asp Asn Phe His Asp Ala Asn Ala Asn Arg Gly Gly Phe 
    370                 375                 380                 


Asp Leu Thr Asp Pro Val Lys Gln Gly Ala Glu Cys Pro His Gln Asn 
385                 390                 395                 400 


Lys Thr Val Leu His Met Asp Gly Cys Leu Asp Thr Glu Thr Pro Thr 
                405                 410                 415     


Val Ser Ile Gln Glu Asn Val Asp Val Ala Ser Leu Lys Pro Ile Ser 
            420                 425                 430         


Asp Ser Gly Ile Asn Phe Thr Asp Ala Ile Trp Ser Pro Thr Cys Glu 
        435                 440                 445             


Arg Arg Thr Cys Glu Cys His Glu Ser Ile Glu Lys Asn Lys Asp Lys 
    450                 455                 460                 


Thr Asp Leu Pro Gln Ser Val Val Tyr Gln Asn Glu Glu Gly Arg Trp 
465                 470                 475                 480 


Val Thr Asp Leu Ala Tyr Tyr Thr Ser Phe Asn Ser Lys Gln Asn Leu 
                485                 490                 495     


Asn Val Ser Leu Ser Asp Glu Met Asn Glu Asp Phe Arg Ser Gly Ser 
            500                 505                 510         


Glu Ala Phe Asp Leu Ile Ala Gln Asp Glu Glu Glu Phe Asn Lys Glu 
        515                 520                 525             


His Gln Phe Ile Gln Glu Glu Asn Ile Asp Ala His Asn Thr Ser Val 
    530                 535                 540                 


Ala Leu Gly Asp Thr Ser Trp Gly Ala Thr Ile Asn Tyr Ser Leu Leu 
545                 550                 555                 560 


Arg Lys Ser Arg Ser Thr Ser Asp Leu Asp Lys Asp Asp Ala Ser Tyr 
                565                 570                 575     


Leu Arg Leu Ser Leu Gly Glu Phe Phe Ala Gln Arg Ser Glu Ala Leu 
            580                 585                 590         


Gly Cys Leu Gly Gly Gly Asn Asn Val Lys Arg Pro Ser Phe Gly Tyr 
        595                 600                 605             


Phe Ile Arg Ser Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys 
    610                 615                 620                 


Ser Asp Val Ser Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn 
625                 630                 635                 640 


His Asp Leu Tyr Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu 
                645                 650                 655     


Ser Glu Gly Ser Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser 
            660                 665                 670         


Gln Val Asp Glu Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr 
        675                 680                 685             


Glu Asp Thr Phe Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys 
    690                 695                 700                 


Leu Pro Asp Ser Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser 
705                 710                 715                 720 


Ala Ile Ala Glu Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala 
                725                 730                 735     


Met Ile Lys Ala Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu 
            740                 745                 750         


Asp Glu Lys Gln Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn 
        755                 760                 765             


Asp Leu Glu Lys Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr 
    770                 775                 780                 


Leu Lys Lys Thr Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe 
785                 790                 795                 800 


Ser Arg Ala Ser Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu 
                805                 810                 815     


Gln Thr Thr Gln Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val 
            820                 825                 830         


Ser Val Arg Ala Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu 
        835                 840                 845             


Asn Gly Glu Ser Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Asn Ser Val Thr Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys 
865                 870                 875                 880 


Thr Cys Ser Ile Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys 
                885                 890                 895     


Ala Thr Ser Ile Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn 
            900                 905                 910         


Pro Arg Ile Thr Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg 
        915                 920                 925             


Asp Asn Arg Glu Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser 
    930                 935                 940                 


Asn Ser Glu Lys His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro 
945                 950                 955                 960 


Lys Asn Ser Asp Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly 
                965                 970                 975     


Ser Glu Asp Glu Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser 
            980                 985                 990         


His Ser Ser Pro Ser Glu Ile Ser  Gly Thr Ser Ser Ser  Gly Cys Ala 
        995                 1000                 1005             


Leu Glu  Ser Phe Gly Ser Ala  Ala Gln Gln Gln Gln  Pro Pro Cys 
    1010                 1015                 1020             


Glu Gln  Glu Leu Ser Pro Leu  Val Cys Ser Pro Ala  Gly Val Ser 
    1025                 1030                 1035             


Arg Leu  Thr Tyr Val Ser Glu  Pro Glu Ser Ser Tyr  Pro Thr Thr 
    1040                 1045                 1050             


Ala Thr  Asp Asp Ala Leu Glu  Asp Arg Lys Ser Asp  Ile Thr Ser 
    1055                 1060                 1065             


Glu Leu  Ser Thr Thr Ile Ile  Gln Gly Ser Pro Ala  Ala Leu Glu 
    1070                 1075                 1080             


Glu Arg  Ala Met Glu Lys Leu  Arg Glu Lys Val Pro  Phe Gln Asn 
    1085                 1090                 1095             


Arg Gly  Lys Gly Thr Leu Ser  Ser Ile Ile Gln Asn  Asn Ser Asp 
    1100                 1105                 1110             


Thr Arg  Lys Ala Thr Glu Thr  Thr Ser Leu Ser Ser  Lys Pro Glu 
    1115                 1120                 1125             


Tyr Val  Lys Pro Asp Phe Arg  Trp Ser Lys Asp Pro  Ser Ser Lys 
    1130                 1135                 1140             


Ser Gly  Asn Leu Leu Glu Thr  Ser Glu Val Gly Trp  Thr Ser Asn 
    1145                 1150                 1155             


Pro Glu  Glu Leu Asp Pro Ile  Arg Leu Ala Leu Leu  Gly Lys Ser 
    1160                 1165                 1170             


Gly Leu  Ser Cys Gln Val Gly  Ser Ala Thr Ser His  Pro Val Ser 
    1175                 1180                 1185             


Cys Gln  Glu Pro Ile Asp Glu  Asp Gln Arg Ile Ser  Pro Lys Asp 
    1190                 1195                 1200             


Lys Ser  Thr Ala Gly Arg Glu  Phe Ser Gly Gln Val  Ser His Gln 
    1205                 1210                 1215             


Thr Thr  Ser Glu Asn Gln Cys  Thr Pro Ile Pro Ser  Ser Thr Val 
    1220                 1225                 1230             


His Ser  Ser Val Ala Asp Met  Gln Asn Met Pro Ala  Ala Val His 
    1235                 1240                 1245             


Ala Leu  Leu Thr Gln Pro Ser  Leu Ser Ala Ala Pro  Phe Ala Gln 
    1250                 1255                 1260             


Arg Tyr  Leu Gly Thr Leu Pro  Ser Thr Gly Ser Thr  Thr Leu Pro 
    1265                 1270                 1275             


Gln Cys  His Ala Gly Asn Ala  Thr Val Cys Gly Phe  Ser Gly Gly 
    1280                 1285                 1290             


Leu Pro  Tyr Pro Ala Val Ala  Gly Glu Pro Val Gln  Asn Ser Val 
    1295                 1300                 1305             


Ala Val  Gly Ile Cys Leu Gly  Ser Asn Ile Gly Ser  Gly Trp Met 
    1310                 1315                 1320             


Gly Thr  Ser Ser Leu Cys Asn  Pro Tyr Ser Asn Thr  Leu Asn Gln 
    1325                 1330                 1335             


Asn Leu  Leu Ser Thr Thr Lys  Pro Phe Pro Val Pro  Ser Val Gly 
    1340                 1345                 1350             


Thr Asn  Cys Gly Ile Glu Pro  Trp Asp Ser Gly Val  Thr Ser Gly 
    1355                 1360                 1365             


Leu Gly  Ser Val Arg Val Pro  Glu Glu Leu Lys Leu  Pro His Ala 
    1370                 1375                 1380             


Cys Cys  Val Gly Ile Ala Ser  Gln Thr Leu Leu Ser  Val Leu Asn 
    1385                 1390                 1395             


Pro Thr  Asp Arg Trp Leu Gln  Val Ser Ile Gly Val  Leu Ser Ile 
    1400                 1405                 1410             


Ser Val  Asn Gly Glu Lys Val  Asp Leu Ser Thr Tyr  Arg Cys Leu 
    1415                 1420                 1425             


Val Phe  Lys Asn Lys Ala Ile  Ile Arg Pro His Ala  Thr Glu Glu 
    1430                 1435                 1440             


Ile Lys  Val Leu Phe Ile Pro  Ser Ser Pro Gly Val  Phe Arg Cys 
    1445                 1450                 1455             


Thr Phe  Ser Val Ala Ser Trp  Pro Cys Ser Thr Asp  Ala Glu Thr 
    1460                 1465                 1470             


Ile Val  Gln Ala Glu Ala Leu  Ala Ser Thr Val Thr  Leu Thr Ala 
    1475                 1480                 1485             


Ile Ala  Glu Ser Pro Val Ile  Glu Val Glu Thr Glu  Lys Lys Asp 
    1490                 1495                 1500             


Val Leu  Asp Phe Gly Asp Leu  Thr Tyr Gly Gly Trp  Lys Ala Leu 
    1505                 1510                 1515             


Pro Leu  Lys Leu Ile Asn Arg  Thr His Ala Thr Val  Pro Ile Arg 
    1520                 1525                 1530             


Leu Ile  Ile Asn Ala Asn Ala  Val Ala Trp Arg Cys  Phe Thr Phe 
    1535                 1540                 1545             


Ser Lys  Glu Ser Val Arg Ala  Pro Val Glu Val Ala  Pro Cys Ala 
    1550                 1555                 1560             


Asp Val  Val Thr Arg Leu Ala  Gly Pro Ser Val Val  Asn His Met 
    1565                 1570                 1575             


Met Pro  Ala Ser Tyr Asp Gly  Gln Asp Pro Glu Phe  Leu Met Ile 
    1580                 1585                 1590             


Trp Val  Leu Phe His Ser Pro  Lys Lys Gln Ile Ser  Ser Ser Asp 
    1595                 1600                 1605             


Ile Leu  Asp Ser Ala Glu Glu  Phe Ser Ala Lys Val  Asp Ile Glu 
    1610                 1615                 1620             


Val Asp  Ser Pro Asn Pro Thr  Pro Val Leu Arg Ser  Val Ser Leu 
    1625                 1630                 1635             


Arg Ala  Arg Ala Gly Ile Ala  Arg Ile His Ala Pro  Arg Asp Leu 
    1640                 1645                 1650             


Gln Thr  Met His Phe Leu Ala  Lys Val Ala Ser Ser  Arg Lys Gln 
    1655                 1660                 1665             


His Leu  Pro Leu Lys Asn Ala  Gly Asn Ile Glu Val  Tyr Leu Asp 
    1670                 1675                 1680             


Ile Lys  Val Pro Glu Gln Gly  Ser His Phe Ser Val  Asp Pro Lys 
    1685                 1690                 1695             


Asn Leu  Leu Leu Lys Pro Gly  Glu Glu His Glu Val  Ile Val Ser 
    1700                 1705                 1710             


Phe Thr  Pro Lys Asp Pro Glu  Ala Cys Glu Glu Arg  Ile Leu Lys 
    1715                 1720                 1725             


Ile Phe  Val Gln Pro Phe Gly  Pro Gln Tyr Glu Val  Val Leu Lys 
    1730                 1735                 1740             


Gly Glu  Val Ile Ser Ser Gly  Ser Lys Pro Leu Ser  Pro Gly Pro 
    1745                 1750                 1755             


Cys Leu  Asp Ile Pro Ser Ile  Leu Ser Asn Lys Gln  Phe Leu Ala 
    1760                 1765                 1770             


Trp Gly  Gly Val Pro Leu Gly  Arg Thr Gln Leu Gln  Lys Leu Ala 
    1775                 1780                 1785             


Leu Arg  Asn Asn Ser Ala Ser  Thr Thr Gln His Leu  Arg Leu Leu 
    1790                 1795                 1800             


Ile Arg  Gly Gln Asp Gln Asp  Cys Phe Gln Leu Gln  Asn Thr Phe 
    1805                 1810                 1815             


Gly Ser  Glu Gln Arg Leu Thr  Ser Asn Cys Glu Ile  Arg Ile His 
    1820                 1825                 1830             


Pro Lys  Glu Asp Ile Phe Ile  Ser Val Leu Phe Ala  Pro Thr Arg 
    1835                 1840                 1845             


Leu Ser  Cys Met Leu Ala Arg  Leu Glu Ile Lys Gln  Leu Gly Asn 
    1850                 1855                 1860             


Arg Ser  Gln Pro Gly Ile Lys  Phe Thr Ile Pro Leu  Ser Gly Tyr 
    1865                 1870                 1875             


Gly Gly  Thr Ser Asn Leu Ile  Leu Glu Gly Val Lys  Lys Leu Ser 
    1880                 1885                 1890             


Asp Ser  Tyr Met Val Thr Val  Asn Gly Leu Val Pro  Gly Lys Glu 
    1895                 1900                 1905             


Ser Lys  Ile Val Phe Ser Val  Arg Asn Thr Gly Ser  Arg Ala Ala 
    1910                 1915                 1920             


Phe Val  Lys Ala Val Gly Phe  Lys Asp Ser Gln Lys  Lys Val Leu 
    1925                 1930                 1935             


Leu Asp  Pro Lys Val Leu Arg  Ile Phe Pro Asp Lys  Phe Val Leu 
    1940                 1945                 1950             


Lys Glu  Arg Thr Gln Glu Asn  Val Thr Leu Ile Tyr  Asn Pro Ser 
    1955                 1960                 1965             


Asp Arg  Gly Ile Asn Asn Lys  Thr Ala Thr Glu Leu  Ser Thr Val 
    1970                 1975                 1980             


Tyr Leu  Phe Gly Gly Asp Glu  Ile Ser Arg Gln Gln  Tyr Arg Arg 
    1985                 1990                 1995             


Ala Leu  Leu His Lys Pro Glu  Met Ile Lys Gln Ile  Leu Pro Glu 
    2000                 2005                 2010             


His Ser  Val Leu Gln Asn Ile  Asn Phe Val Glu Ala  Phe Gln Asp 
    2015                 2020                 2025             


Glu Leu  Leu Val Thr Glu Val  Tyr Asp Leu Pro Gln  Arg Pro Asn 
    2030                 2035                 2040             


Asp Val  Gln Leu Phe Tyr Gly  Ser Met Cys Lys Ile  Ile Leu Ser 
    2045                 2050                 2055             


Val Ile  Gly Glu Phe Arg Asp  Cys Ile Ser Ser Arg  Glu Phe Leu 
    2060                 2065                 2070             


Gln Pro  Ser Ser Lys Ala Ser  Leu Glu Ser Thr Ser  Asp Leu Gly 
    2075                 2080                 2085             


Ala Ser  Gly Lys His Gly Gly  Asn Val Ser Leu Asp  Val Leu Pro 
    2090                 2095                 2100             


Val Lys  Gly Pro Gln Gly Ser  Pro Leu Leu Ser Arg  Ala Ala Arg 
    2105                 2110                 2115             


Pro Pro  Leu Asp Gln Leu Ala  Ser Glu Glu Pro Trp  Thr Val Leu 
    2120                 2125                 2130             


Pro Glu  His Leu Ile Leu Val  Ala Pro Ser Pro Cys  Asp Met Ala 
    2135                 2140                 2145             


Lys Thr  Gly Arg Phe Gln Ile  Val Asn Asn Ser Val  Arg Leu Leu 
    2150                 2155                 2160             


Arg Phe  Glu Leu Cys Trp Pro  Ala His Cys Leu Thr  Val Thr Pro 
    2165                 2170                 2175             


Gln His  Gly Cys Val Ala Pro  Glu Ser Lys Leu Gln  Ile Leu Val 
    2180                 2185                 2190             


Ser Pro  Asn Ser Ser Leu Ser  Thr Lys Gln Ser Met  Phe Pro Trp 
    2195                 2200                 2205             


Ser Gly  Leu Ile Tyr Ile His  Cys Asp Asp Gly Gln  Lys Lys Ile 
    2210                 2215                 2220             


Val Lys  Val Gln Ile Arg Glu  Asp Leu Thr Gln Val  Glu Leu Leu 
    2225                 2230                 2235             


Thr Arg  Leu Thr Ser Lys Pro  Phe Gly Ile Leu Ser  Pro Val Ser 
    2240                 2245                 2250             


Glu Pro  Ser Val Ser His Leu  Val Lys Pro Met Thr  Lys Pro Pro 
    2255                 2260                 2265             


Ser Thr  Lys Val Glu Ile Arg  Asn Lys Ser Ile Thr  Phe Pro Thr 
    2270                 2275                 2280             


Thr Glu  Pro Gly Glu Thr Ser  Glu Ser Cys Leu Glu  Leu Glu Asn 
    2285                 2290                 2295             


His Gly  Thr Thr Asp Val Lys  Trp His Leu Ser Ser  Leu Ala Pro 
    2300                 2305                 2310             


Pro Tyr  Val Lys Gly Val Asp  Glu Ser Gly Asp Val  Phe Arg Ala 
    2315                 2320                 2325             


Thr Tyr  Ala Ala Phe Arg Cys  Ser Pro Ile Ser Gly  Leu Leu Glu 
    2330                 2335                 2340             


Ser His  Gly Ile Gln Lys Val  Ser Ile Thr Phe Leu  Pro Arg Gly 
    2345                 2350                 2355             


Arg Gly  Asp Tyr Ala Gln Phe  Trp Asp Val Glu Cys  His Pro Leu 
    2360                 2365                 2370             


Lys Glu  Pro His Met Lys His  Thr Leu Arg Phe Gln  Leu Ser Gly 
    2375                 2380                 2385             


Gln Ser  Ile Glu Ala Glu Asn  Glu Pro Glu Asn Ala  Cys Leu Ser 
    2390                 2395                 2400             


Thr Asp  Ser Leu Ile Lys Ile  Asp His Leu Val Lys  Pro Arg Arg 
    2405                 2410                 2415             


Gln Ala  Val Ser Glu Ala Ser  Ala Arg Ile Pro Glu  Gln Leu Asp 
    2420                 2425                 2430             


Val Thr  Ala Arg Gly Val Tyr  Ala Pro Glu Asp Val  Tyr Arg Phe 
    2435                 2440                 2445             


Arg Pro  Thr Ser Val Gly Glu  Ser Arg Thr Leu Lys  Val Asn Leu 
    2450                 2455                 2460             


Arg Asn  Asn Ser Phe Ile Thr  His Ser Leu Lys Phe  Leu Ser Pro 
    2465                 2470                 2475             


Arg Glu  Pro Phe Tyr Val Lys  His Ser Lys Tyr Ser  Leu Arg Ala 
    2480                 2485                 2490             


Gln His  Tyr Ile Asn Met Pro  Val Gln Phe Lys Pro  Lys Ser Ala 
    2495                 2500                 2505             


Gly Lys  Phe Glu Ala Leu Leu  Val Ile Gln Thr Asp  Glu Gly Lys 
    2510                 2515                 2520             


Ser Ile  Ala Ile Arg Leu Ile  Gly Glu Ala Leu Gly  Lys Asn 
    2525                 2530                 2535         


<210>  1168
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  1168

Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Thr Leu Ala Leu 
                85                  90                  95      


Arg Phe Gly Asn Gln Thr Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            100                 105                 110         


His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Thr 
        115                 120                 125             


Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr Lys Ala Ala Glu Tyr Ile 
    130                 135                 140                 


Ser Lys Met Thr Thr Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Thr 
145                 150                 155                 160 


Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu 
                165                 170                 175     


Pro Arg Lys Thr Asn Val Thr His Glu Glu His Thr Ala Val Glu Lys 
            180                 185                 190         


Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Thr His Asn Asp Asn His 
        195                 200                 205             


Phe Asn Tyr Glu Lys Thr His Asn Phe Lys Val His Thr Phe Arg Gly 
    210                 215                 220                 


Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala 
225                 230                 235                 240 


Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys 
                245                 250                 255     


Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile Lys 
            260                 265                 270         


Lys Val Tyr Cys Cys Asp Leu Thr Thr Leu Val Lys Ala His Asn Thr 
        275                 280                 285             


Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala Arg 
    290                 295                 300                 


Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Thr Glu His 
305                 310                 315                 320 


Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp 
                325                 330                 335     


Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Thr Gly Ala Leu 
            340                 345                 350         


Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Thr Tyr Asp Thr 
        355                 360                 365             


Tyr Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg 
    370                 375                 380                 


Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
385                 390                 395                 400 


Glu Thr Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Thr Met Asn 
                405                 410                 415     


Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
            420                 425                 430         


Pro Thr Leu Met Arg Pro Pro Glu Asp Ser Thr Leu Thr Thr Leu His 
        435                 440                 445             


Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
    450                 455                 460                 


Asp Val Leu Phe 
465             


<210>  1169
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  1169

Met Thr Ile Glu Asp Leu Pro Asp Phe Pro Leu Glu Gly Asn Pro Leu 
1               5                   10                  15      


Phe Gly Arg Tyr Pro Phe Ile Phe Ser Ala Ser Asp Thr Pro Val Ile 
            20                  25                  30          


Phe Ser Ile Ser Ala Ala Pro Met Pro Ser Asp Cys Glu Phe Ser Phe 
        35                  40                  45              


Phe Asp Pro Asn Asp Ala Ser Cys Gln Glu Ile Leu Phe Asp Pro Lys 
    50                  55                  60                  


Thr Ser Val Ser Glu Leu Phe Ala Ile Leu Arg Gln Trp Val Pro Gln 
65                  70                  75                  80  


Val Gln Gln Asn Ile Asp Ile Ile Gly Asn Glu Ile Leu Lys Arg Gly 
                85                  90                  95      


Cys Asn Val Asn Asp Arg Asp Gly Leu Thr Asp Met Thr Leu Leu His 
            100                 105                 110         


Tyr Thr Cys Lys Ser Gly Ala His Gly Ile Gly Asp Val Glu Thr Ala 
        115                 120                 125             


Val Lys Phe Ala Thr Gln Leu Ile Asp Leu Gly Ala Asp Ile Ser Leu 
    130                 135                 140                 


Arg Ser Arg Trp Thr Asn Met Asn Ala Leu His Tyr Ala Ala Tyr Phe 
145                 150                 155                 160 


Asp Val Pro Glu Leu Ile Arg Val Ile Leu Lys Thr Ser Lys Pro Lys 
                165                 170                 175     


Asp Val Asp Ala Thr Cys Ser Asp Phe Asn Phe Gly Thr Ala Leu His 
            180                 185                 190         


Ile Ala Ala Tyr Asn Leu Cys Ala Gly Ala Val Lys Cys Leu Leu Glu 
        195                 200                 205             


Gln Gly Ala Asn Pro Ala Phe Arg Asn Asp Lys Gly Gln Ile Pro Ala 
    210                 215                 220                 


Asp Val Val Pro Asp Pro Val Asp Met Pro Leu Glu Met Ala Asp Ala 
225                 230                 235                 240 


Ala Ala Thr Ala Lys Glu Ile Lys Gln Met Leu Leu Asp Ala Val Pro 
                245                 250                 255     


Leu Ser Cys Asn Ile Ser Lys Ala Met Leu Pro Asn Tyr Asp His Val 
            260                 265                 270         


Thr Gly Lys Ala Met Leu Thr Ser Leu Gly Leu Lys Leu Gly Asp Arg 
        275                 280                 285             


Val Val Ile Ala Gly Gln Lys Val Gly Thr Leu Arg Phe Cys Gly Thr 
    290                 295                 300                 


Thr Glu Phe Ala Ser Gly Gln Trp Ala Gly Ile Glu Leu Asp Glu Pro 
305                 310                 315                 320 


Glu Gly Lys Asn Asn Gly Ser Val Gly Lys Val Gln Tyr Phe Lys Cys 
                325                 330                 335     


Ala Pro Lys Tyr Gly Ile Phe Ala Pro Leu Ser Lys Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Arg Arg Lys Asn Ile Thr His Thr Pro Ser Thr Lys Ala Ala 
        355                 360                 365             


Val Pro Leu Ile Arg Ser Gln Lys Ile Asp Val Ala His Val Thr Ser 
    370                 375                 380                 


Lys Val Asn Thr Gly Leu Met Thr Ser Lys Lys Asp Ser Ala Ser Glu 
385                 390                 395                 400 


Ser Thr Leu Ser Leu Pro Pro Gly Glu Glu Leu Lys Thr Val Thr Glu 
                405                 410                 415     


Lys Asp Val Ala Leu Leu Gly Ser Val Ser Ser Cys Ser Ser Thr Ser 
            420                 425                 430         


Ser Leu Glu His Arg Gln Ser Tyr Pro Lys Lys Gln Asn Ala Ile Ser 
        435                 440                 445             


Ser Asn Lys Lys Thr Met Ser Lys Ser Pro Ser Leu Ser Ser Arg Ala 
    450                 455                 460                 


Ser Ala Gly Leu Asn Ser Ser Ala Thr Ser Thr Ala Asn Asn Ser Arg 
465                 470                 475                 480 


Cys Glu Gly Glu Leu Arg Leu Gly Glu Arg Val Leu Val Val Gly Gln 
                485                 490                 495     


Arg Leu Gly Thr Ile Arg Phe Phe Gly Thr Thr Asn Phe Ala Pro Gly 
            500                 505                 510         


Tyr Trp Tyr Gly Ile Glu Leu Glu Lys Pro His Gly Lys Asn Asp Gly 
        515                 520                 525             


Ser Val Gly Gly Val Gln Tyr Phe Ser Cys Ser Pro Arg Tyr Gly Ile 
    530                 535                 540                 


Phe Ala Pro Pro Ser Arg Val Gln Arg Val Thr Asp Ser Leu Asp Thr 
545                 550                 555                 560 


Leu Ser Glu Ile Ser Ser Asn Lys Gln Asn His Ser Tyr Pro Gly Phe 
                565                 570                 575     


Arg Arg Ser Phe Ser Thr Thr Ser Ala Ser Ser Gln Lys Glu Ile Asn 
            580                 585                 590         


Arg Arg Asn Ala Phe Ser Lys Ser Lys Ala Ala Leu Arg Arg Ser Trp 
        595                 600                 605             


Ser Ser Thr Pro Thr Ala Gly Gly Ile Glu Gly Ser Val Lys Leu His 
    610                 615                 620                 


Glu Gly Ser Gln Val Leu Leu Thr Ser Ser Asn Glu Met Gly Thr Val 
625                 630                 635                 640 


Arg Tyr Val Gly Pro Thr Asp Phe Ala Ser Gly Ile Trp Leu Gly Leu 
                645                 650                 655     


Glu Leu Arg Ser Ala Lys Gly Lys Asn Asp Gly Ser Val Gly Asp Lys 
            660                 665                 670         


Arg Tyr Phe Thr Cys Lys Pro Asn His Gly Val Leu Val Arg Pro Ser 
        675                 680                 685             


Arg Val Thr Tyr Arg Gly Ile Asn Gly Ser Lys Leu Val Asp Glu Asn 
    690                 695                 700                 


Cys 
705 


<210>  1170
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1170

Met Pro Ala Ala Thr Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Thr Glu Phe Pro Gly Val Val Ala 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Thr 
65                  70                  75                  80  


Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Thr Ser Thr Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Thr Glu Asp Met Tyr Ala Gln Asp Ser 
            100                 105                 110         


Ile Glu Leu Leu Thr Thr Ser Gly Ile Gln Phe Lys Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Glu Thr Gln Tyr Phe Ala Glu Leu Leu Met Thr Ser Gly 
    130                 135                 140                 


Val Val Leu Cys Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr 
145                 150                 155                 160 


Asp Phe Gly Tyr Leu Ile Lys Ile Leu Thr Asn Ser Asn Leu Pro Glu 
                165                 170                 175     


Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile 
            180                 185                 190         


Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly 
        195                 200                 205             


Leu Gln Glu Val Ala Glu Gln Leu Glu Leu Glu Arg Ile Gly Pro Gln 
    210                 215                 220                 


His Gln Ala Gly Ser Asp Ser Leu Leu Thr Gly Met Ala Phe Phe Lys 
225                 230                 235                 240 


Met Arg Glu Met Phe Phe Glu Asp His Ile Asp Asp Ala Lys Tyr Cys 
                245                 250                 255     


Gly His Leu Tyr Gly Leu Gly Ser Gly Ser Ser Tyr Val Gln Asn Gly 
            260                 265                 270         


Thr Gly Asn Ala Tyr Glu Glu Glu Ala Asn Lys Gln Ser 
        275                 280                 285 


<210>  1171
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  1171

Met Asp Phe Asp Lys Lys Gly Gly Lys Gly Glu Thr Glu Glu Gly Arg 
1               5                   10                  15      


Arg Met Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser 
            20                  25                  30          


Ser Gly Thr Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val 
        35                  40                  45              


Gly Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys 
    50                  55                  60                  


Asn Leu Tyr Thr Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys 
65                  70                  75                  80  


Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu 
                85                  90                  95      


Ser Ala Thr Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly 
            100                 105                 110         


Lys Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp 
        115                 120                 125             


Leu Phe Asp Leu Cys Asp Arg Thr Phe Thr Leu Lys Thr Val Leu Met 
    130                 135                 140                 


Ile Ala Ile Gln Leu Ile Thr Arg Met Glu Tyr Val His Thr Lys Ser 
145                 150                 155                 160 


Leu Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro 
                165                 170                 175     


Gly Thr Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala 
            180                 185                 190         


Lys Glu Tyr Ile Asp Pro Glu Thr Lys Lys His Ile Pro Tyr Arg Glu 
        195                 200                 205             


His Lys Ser Leu Thr Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr His 
    210                 215                 220                 


Leu Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His 
225                 230                 235                 240 


Met Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys 
                245                 250                 255     


Ala Asp Thr Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Thr Lys Arg 
            260                 265                 270         


Ala Thr Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala 
        275                 280                 285             


Thr Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp 
    290                 295                 300                 


Tyr Asp Tyr Leu Arg Lys Leu Phe Thr Asp Leu Phe Asp Arg Ser Gly 
305                 310                 315                 320 


Phe Val Phe Asp Tyr Glu Tyr Asp Trp Ala Gly Lys Pro Leu Pro Thr 
                325                 330                 335     


Pro Ile Gly Thr Val His Thr Asp Leu Pro Ser Gln Pro Gln Leu Arg 
            340                 345                 350         


Asp Lys Thr Gln Pro His Ser Lys Asn Gln Ala Leu Asn Ser Thr Asn 
        355                 360                 365             


Gly Glu Leu Asn Ala Asp Asp Pro Thr Ala Gly His Ser Asn Ala Pro 
    370                 375                 380                 


Ile Thr Ala Pro Ala Glu Val Glu Val Ala Asp Glu Thr Lys Cys Cys 
385                 390                 395                 400 


Cys Phe Phe Lys Arg Arg Lys Arg Lys Ser Leu Gln Arg His Lys 
                405                 410                 415 


<210>  1172
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  1172

Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
1               5                   10                  15      


Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
            20                  25                  30          


Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
    50                  55                  60                  


Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
65                  70                  75                  80  


Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                85                  90                  95      


Tyr Phe 
        


<210>  1173
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  1173

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Asp Gly Leu Val Asn 
        275                 280                 285             


Val Gly Trp Met Asp Cys Ala Thr Gln Asp Asn Leu Cys Lys Ser Leu 
    290                 295                 300                 


Asp Ile Thr Thr Ser Thr Thr Ala Tyr Phe Pro Pro Gly Ala Thr Leu 
305                 310                 315                 320 


Asn Asn Lys Glu Lys Asn Ser Ile Leu Phe Leu Asn Ser Leu Asp Ala 
                325                 330                 335     


Lys Glu Ile Tyr Leu Glu Val Ile His Asn Leu Pro Asp Phe Glu Leu 
            340                 345                 350         


Leu Ser Ala Asn Thr Leu Glu Asp Arg Leu Ala His His Arg Trp Leu 
        355                 360                 365             


Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Pro Glu Leu 
    370                 375                 380                 


Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln Val Gly Arg 
385                 390                 395                 400 


Phe Asp Cys Ser Ser Ala Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe 
                405                 410                 415     


Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu 
            420                 425                 430         


Ile His His Gly Lys Lys Ile Leu Tyr Asp Ile Leu Ala Phe Ala Lys 
        435                 440                 445             


Glu Ser Val Asn Ser His Val Thr Thr Leu Gly Pro Gln Asn Phe Pro 
    450                 455                 460                 


Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys 
465                 470                 475                 480 


Pro Pro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu 
                485                 490                 495     


Leu Tyr Gly Gln Leu Lys Phe Gly Thr Leu Asp Cys Thr Val His Glu 
            500                 505                 510         


Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val 
        515                 520                 525             


Phe Asn Gln Ser Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu 
    530                 535                 540                 


Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser 
545                 550                 555                 560 


Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn 
                565                 570                 575     


Glu Val Trp Met Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln 
            580                 585                 590         


Val Leu Met Pro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu 
        595                 600                 605             


Ile Asn Val Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala 
    610                 615                 620                 


Gln Glu Asn Val Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys 
625                 630                 635                 640 


Ser Asn Lys Ala Tyr His Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp 
                645                 650                 655     


Ala Tyr Ser Leu Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser 
            660                 665                 670         


Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys 
        675                 680                 685             


Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln 
    690                 695                 700                 


Asn Phe Ala Pro Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys 
705                 710                 715                 720 


Val Lys Ala Gly Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln 
                725                 730                 735     


Lys Ala Gly Ile Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu 
            740                 745                 750         


Arg Ala Lys Arg Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala 
        755                 760                 765             


Lys Ala Ile Ala Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn 
    770                 775                 780                 


Gln Gly Lys Arg Asn Lys Asp Glu Leu 
785                 790             


<210>  1174
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  1174

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  1175
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  1175

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  1176
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1176

Met Ser Glu Thr Pro Ala Gln Cys Ser Ile Lys Gln Glu Arg Ile Ser 
1               5                   10                  15      


Tyr Thr Pro Pro Glu Ser Pro Val Pro Ser Tyr Ala Ser Ser Thr Pro 
            20                  25                  30          


Leu His Val Pro Val Pro Arg Ala Leu Arg Met Glu Glu Asp Ser Ile 
        35                  40                  45              


Arg Leu Pro Ala His Leu Arg Leu Gln Pro Ile Tyr Trp Ser Arg Asp 
    50                  55                  60                  


Asp Val Ala Gln Trp Leu Lys Trp Ala Glu Asn Glu Phe Ser Leu Arg 
65                  70                  75                  80  


Pro Ile Asp Ser Asn Thr Phe Glu Met Asn Gly Lys Ala Leu Leu Leu 
                85                  90                  95      


Leu Thr Lys Glu Asp Phe Arg Tyr Arg Ser Pro His Ser Gly Asp Val 
            100                 105                 110         


Leu Tyr Glu Leu Leu Gln His Ile Leu Lys Gln Arg Lys Pro Arg Ile 
        115                 120                 125             


Leu Phe Ser Pro Phe Phe His Pro Gly Asn Ser Ile His Thr Gln Pro 
    130                 135                 140                 


Glu Val Ile Leu His Gln Asn His Glu Glu Asp Asn Cys Val Gln Arg 
145                 150                 155                 160 


Thr Pro Arg Pro Ser Val Asp Asn Val His His Asn Pro Pro Thr Ile 
                165                 170                 175     


Glu Leu Leu His Arg Ser Arg Ser Pro Ile Thr Thr Asn His Arg Pro 
            180                 185                 190         


Ser Pro Asp Pro Glu Gln Arg Pro Leu Arg Ser Pro Leu Asp Asn Met 
        195                 200                 205             


Ile Arg Arg Leu Ser Pro Ala Glu Arg Ala Gln Gly Pro Arg Pro His 
    210                 215                 220                 


Gln Glu Asn Asn His Gln Glu Ser Tyr Pro Leu Ser Val Ser Pro Met 
225                 230                 235                 240 


Glu Asn Asn His Cys Pro Ala Ser Ser Glu Ser His Pro Lys Pro Ser 
                245                 250                 255     


Ser Pro Arg Gln Glu Ser Thr Arg Val Ile Gln Leu Met Pro Ser Pro 
            260                 265                 270         


Ile Met His Pro Leu Ile Leu Asn Pro Arg His Ser Val Asp Phe Lys 
        275                 280                 285             


Gln Ser Arg Leu Ser Glu Asp Gly Leu His Arg Glu Gly Lys Pro Ile 
    290                 295                 300                 


Asn Leu Ser His Arg Glu Asp Leu Ala Tyr Met Asn His Ile Met Val 
305                 310                 315                 320 


Ser Val Ser Pro Pro Glu Glu His Ala Met Pro Ile Gly Arg Ile Ala 
                325                 330                 335     


Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Ser Asp Ser 
            340                 345                 350         


Arg Tyr Glu Asn Phe Ile Arg Trp Glu Asp Lys Glu Ser Lys Ile Phe 
        355                 360                 365             


Arg Ile Val Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys 
    370                 375                 380                 


Asn Arg Thr Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His 
385                 390                 395                 400 


Tyr Tyr Lys Leu Asn Ile Ile Arg Lys Glu Pro Gly Gln Arg Leu Leu 
                405                 410                 415     


Phe Arg Phe Met Lys Thr Pro Asp Glu Ile Met Ser Gly Arg Thr Asp 
            420                 425                 430         


Arg Leu Glu His Leu Glu Ser Gln Glu Leu Asp Glu Gln Ile Tyr Gln 
        435                 440                 445             


Glu Asp Glu Cys 
    450         


<210>  1177
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  1177

Met Ala Pro Pro Ser Thr Arg Glu Pro Arg Val Leu Ser Ala Thr Ser 
1               5                   10                  15      


Ala Thr Lys Ser Asp Gly Glu Met Val Leu Pro Gly Phe Pro Asp Ala 
            20                  25                  30          


Asp Ser Phe Val Lys Phe Ala Leu Gly Ser Val Val Ala Val Thr Lys 
        35                  40                  45              


Ala Ser Gly Gly Leu Pro Gln Phe Gly Asp Glu Tyr Asp Phe Tyr Arg 
    50                  55                  60                  


Ser Phe Pro Gly Phe Gln Ala Phe Cys Glu Thr Gln Gly Asp Arg Leu 
65                  70                  75                  80  


Leu Gln Cys Met Ser Arg Val Met Gln Tyr His Gly Cys Arg Ser Asn 
                85                  90                  95      


Ile Lys Asp Arg Ser Lys Val Thr Glu Leu Glu Asp Lys Phe Asp Leu 
            100                 105                 110         


Leu Val Asp Ala Asn Asp Val Ile Leu Glu Arg Val Gly Ile Leu Leu 
        115                 120                 125             


Asp Glu Ala Ser Gly Val Asn Lys Asn Gln Gln Pro Val Leu Pro Ala 
    130                 135                 140                 


Gly Leu Gln Val Pro Lys Thr Val Val Ser Ser Trp Asn Arg Lys Ala 
145                 150                 155                 160 


Ala Glu Tyr Gly Lys Lys Ala Lys Ser Glu Thr Phe Arg Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ile Ile Arg Pro Gln Leu Lys Phe Arg Glu Lys Ile Asp 
            180                 185                 190         


Asn Ser Asn Thr Pro Phe Leu Pro Lys Ile Phe Ile Lys Pro Asn Ala 
        195                 200                 205             


Gln Lys Pro Leu Pro Gln Ala Leu Ser Lys Glu Arg Arg Glu Arg Pro 
    210                 215                 220                 


Gln Asp Arg Pro Glu Asp Leu Asp Val Pro Pro Ala Leu Ala Asp Phe 
225                 230                 235                 240 


Ile His Gln Gln Arg Thr Gln Gln Val Glu Gln Asp Met Phe Ala His 
                245                 250                 255     


Pro Tyr Gln Tyr Glu Leu Asn His Phe Thr Pro Ala Asp Ala Val Leu 
            260                 265                 270         


Gln Lys Pro Gln Pro Gln Leu Tyr Arg Pro Ile Glu Glu Thr Pro Cys 
        275                 280                 285             


His Phe Ile Ser Ser Leu Asp Glu Leu Val Glu Leu Asn Glu Lys Leu 
    290                 295                 300                 


Leu Asn Cys Gln Glu Phe Ala Val Asp Leu Glu His His Ser Tyr Arg 
305                 310                 315                 320 


Ser Phe Leu Gly Leu Thr Cys Leu Met Gln Ile Ser Thr Arg Thr Glu 
                325                 330                 335     


Asp Phe Ile Ile Asp Thr Leu Glu Leu Arg Ser Asp Met Tyr Ile Leu 
            340                 345                 350         


Asn Glu Ser Leu Thr Asp Pro Ala Ile Val Lys Val Phe His Gly Ala 
        355                 360                 365             


Asp Ser Asp Ile Glu Trp Leu Gln Lys Asp Phe Gly Leu Tyr Val Val 
    370                 375                 380                 


Asn Met Phe Asp Thr His Gln Ala Ala Arg Leu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


His Ser Leu Asp His Leu Leu Lys Leu Tyr Cys Asn Val Asp Ser Asn 
                405                 410                 415     


Lys Gln Tyr Gln Leu Ala Asp Trp Arg Ile Arg Pro Leu Pro Glu Glu 
            420                 425                 430         


Met Leu Ser Tyr Ala Arg Asp Asp Thr His Tyr Leu Leu Tyr Ile Tyr 
        435                 440                 445             


Asp Lys Met Arg Leu Glu Met Trp Glu Arg Gly Asn Gly Gln Pro Val 
    450                 455                 460                 


Gln Leu Gln Val Val Trp Gln Arg Ser Arg Asp Ile Cys Leu Lys Lys 
465                 470                 475                 480 


Phe Ile Lys Pro Ile Phe Thr Asp Glu Ser Tyr Leu Glu Leu Tyr Arg 
                485                 490                 495     


Lys Gln Lys Lys His Leu Asn Thr Gln Gln Leu Thr Ala Phe Gln Leu 
            500                 505                 510         


Leu Phe Ala Trp Arg Asp Lys Thr Ala Arg Arg Glu Asp Glu Ser Tyr 
        515                 520                 525             


Gly Tyr Val Leu Pro Asn His Met Met Leu Lys Ile Ala Glu Glu Leu 
    530                 535                 540                 


Pro Lys Glu Pro Gln Gly Ile Ile Ala Cys Cys Asn Pro Val Pro Pro 
545                 550                 555                 560 


Leu Val Arg Gln Gln Ile Asn Glu Met His Leu Leu Ile Gln Gln Ala 
                565                 570                 575     


Arg Glu Met Pro Leu Leu Lys Ser Glu Val Ala Ala Gly Val Lys Lys 
            580                 585                 590         


Ser Gly Pro Leu Pro Ser Ala Glu Arg Leu Glu Asn Val Leu Phe Gly 
        595                 600                 605             


Pro His Asp Cys Ser His Ala Pro Pro Asp Gly Tyr Pro Ile Ile Pro 
    610                 615                 620                 


Thr Ser Gly Ser Val Pro Val Gln Lys Gln Ala Ser Leu Phe Pro Asp 
625                 630                 635                 640 


Glu Lys Glu Asp Asn Leu Leu Gly Thr Thr Cys Leu Ile Ala Thr Ala 
                645                 650                 655     


Val Ile Thr Leu Phe Asn Glu Pro Ser Ala Glu Asp Ser Lys Lys Gly 
            660                 665                 670         


Pro Leu Thr Val Ala Gln Lys Lys Ala Gln Asn Ile Met Glu Ser Phe 
        675                 680                 685             


Glu Asn Pro Phe Arg Met Ile Ser Asn Arg Trp Lys Leu Ala Gln Val 
    690                 695                 700                 


Gln Val Gln Lys Asp Ser Lys Glu Ala Val Lys Lys Lys Ala Ala Glu 
705                 710                 715                 720 


Gln Thr Ala Ala Arg Glu Gln Ala Lys Glu Ala Cys Lys Ala Ala Ala 
                725                 730                 735     


Glu Gln Ala Ile Ser Val Arg Gln Gln Val Val Leu Glu Asn Ala Ala 
            740                 745                 750         


Lys Lys Arg Glu Arg Ala Thr Ser Asp Pro Arg Thr Thr Glu Gln Lys 
        755                 760                 765             


Gln Glu Lys Lys Arg Leu Lys Ile Ser Lys Lys Pro Lys Asp Pro Glu 
    770                 775                 780                 


Pro Pro Glu Lys Glu Phe Thr Pro Tyr Asp Tyr Ser Gln Ser Asp Phe 
785                 790                 795                 800 


Lys Ala Phe Ala Gly Asn Ser Lys Ser Lys Val Ser Ser Gln Phe Asp 
                805                 810                 815     


Pro Asn Lys Gln Thr Pro Ser Gly Lys Lys Cys Ile Ala Ala Lys Lys 
            820                 825                 830         


Ile Lys Gln Ser Val Gly Asn Lys Ser Met Ser Phe Pro Thr Gly Lys 
        835                 840                 845             


Ser Asp Arg Gly Phe Arg Tyr Asn Trp Pro Gln Arg 
    850                 855                 860 


<210>  1178
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1178

Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Ala Glu 
    130                 135                 140                 


Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr Arg Ser 
145                 150                 155                 160 


Leu Lys Tyr Gly Lys Leu Gly Gln Gly Val Leu Val Gln Val Ser Pro 
                165                 170                 175     


Ser Leu Val Lys Arg Gln Lys Thr His Phe His Asp Leu Pro Cys Gly 
            180                 185                 190         


Ala Ser Val Ile Leu Gly Asn Asn Gly Phe Ile Trp Ile Tyr Pro Thr 
        195                 200                 205             


Pro Glu His Lys Glu Glu Glu Ala Gly Gly Phe Ile Ala Asn Leu Glu 
    210                 215                 220                 


Pro Val Ser Leu Ala Asp Arg Glu Val Ile Ser Arg Leu Arg Asn Cys 
225                 230                 235                 240 


Ile Ile Ser Leu Val Thr Gln Arg Met Met Leu Tyr Asp Thr Ser Ile 
                245                 250                 255     


Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His Gln Ile Lys Asp Ile Leu 
            260                 265                 270         


Lys Pro Glu Ile Met Glu Glu Ile Val Met Glu Thr Arg Gln Arg Leu 
        275                 280                 285             


Leu Glu Gln Glu Gly 
    290             


<210>  1179
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  1179

Met Lys Glu Thr Pro Leu Ser Asn Cys Glu Arg Arg Phe Leu Leu Arg 
1               5                   10                  15      


Ala Ile Glu Glu Lys Lys Arg Leu Asp Gly Arg Gln Thr Tyr Asp Tyr 
            20                  25                  30          


Arg Asn Ile Arg Ile Ser Phe Gly Thr Asp Tyr Gly Cys Cys Ile Val 
        35                  40                  45              


Glu Leu Gly Lys Thr Arg Val Leu Gly Gln Val Ser Cys Glu Leu Val 
    50                  55                  60                  


Ser Pro Lys Leu Asn Arg Ala Thr Glu Gly Ile Leu Phe Phe Asn Leu 
65                  70                  75                  80  


Glu Leu Ser Gln Met Ala Ala Pro Ala Phe Glu Pro Gly Arg Gln Ser 
                85                  90                  95      


Asp Leu Leu Val Lys Leu Asn Arg Leu Met Glu Arg Cys Leu Arg Asn 
            100                 105                 110         


Ser Lys Cys Ile Asp Thr Glu Ser Leu Cys Val Val Ala Gly Glu Lys 
        115                 120                 125             


Val Trp Gln Ile Arg Val Asp Leu His Leu Leu Asn His Asp Gly Asn 
    130                 135                 140                 


Ile Ile Asp Ala Ala Ser Ile Ala Ala Ile Val Ala Leu Cys His Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Val Ser Val Gln Gly Asp Glu Val Thr Leu Tyr Thr 
                165                 170                 175     


Pro Glu Glu Arg Asp Pro Val Pro Leu Ser Ile His His Met Pro Ile 
            180                 185                 190         


Cys Val Ser Phe Ala Phe Phe Gln Gln Gly Thr Tyr Leu Leu Val Asp 
        195                 200                 205             


Pro Asn Glu Arg Glu Glu Arg Val Met Asp Gly Leu Leu Val Ile Ala 
    210                 215                 220                 


Met Asn Lys His Arg Glu Ile Cys Thr Ile Gln Ser Ser Gly Gly Ile 
225                 230                 235                 240 


Met Leu Leu Lys Asp Gln Val Leu Arg Cys Ser Lys Ile Ala Gly Val 
                245                 250                 255     


Lys Val Ala Glu Ile Thr Glu Leu Ile Leu Lys Ala Leu Glu Asn Asp 
            260                 265                 270         


Gln Lys Val Arg Lys Glu Gly Gly Lys Phe Gly Phe Ala Glu Ser Ile 
        275                 280                 285             


Ala Asn Gln Arg Ile Thr Ala Phe Lys Met Glu Lys Ala Pro Ile Asp 
    290                 295                 300                 


Thr Ser Asp Val Glu Glu Lys Ala Glu Glu Ile Ile Ala Glu Ala Glu 
305                 310                 315                 320 


Pro Pro Ser Glu Val Val Ser Thr Pro Val Leu Trp Thr Pro Gly Thr 
                325                 330                 335     


Ala Gln Ile Gly Glu Gly Val Glu Asn Ser Trp Gly Asp Leu Glu Asp 
            340                 345                 350         


Ser Glu Lys Glu Asp Asp Glu Gly Gly Gly Asp Gln Ala Ile Ile Leu 
        355                 360                 365             


Asp Gly Ile Lys Met Asp Thr Gly Val Glu Val Ser Asp Ile Gly Ser 
    370                 375                 380                 


Gln Asp Ala Pro Ile Ile Leu Ser Asp Ser Glu Glu Glu Glu Met Ile 
385                 390                 395                 400 


Ile Leu Glu Pro Asp Lys Asn Pro Lys Lys Ile Arg Thr Gln Thr Thr 
                405                 410                 415     


Ser Ala Lys Gln Glu Lys Ala Pro Ser Lys Lys Pro Val Lys Arg Arg 
            420                 425                 430         


Lys Lys Lys Arg Ala Ala Asn 
        435                 


<210>  1180
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  1180

Met Lys Pro Gly Phe Ser Pro Arg Gly Gly Gly Phe Gly Gly Arg Gly 
1               5                   10                  15      


Gly Phe Gly Asp Arg Gly Gly Arg Gly Gly Arg Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Arg Gly Arg Gly Gly Gly Phe Arg Gly Arg Gly Arg Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly Gly Gly Gly Phe 
    50                  55                  60                  


His Ser Gly Gly Asn Arg Gly Arg Gly Arg Gly Gly Lys Arg Gly Asn 
65                  70                  75                  80  


Gln Ser Gly Lys Asn Val Met Val Glu Pro His Arg His Glu Gly Val 
                85                  90                  95      


Phe Ile Cys Arg Gly Lys Glu Asp Ala Leu Val Thr Lys Asn Leu Val 
            100                 105                 110         


Pro Gly Glu Ser Val Tyr Gly Glu Lys Arg Val Ser Ile Ser Glu Gly 
        115                 120                 125             


Asp Asp Lys Ile Glu Tyr Arg Ala Trp Asn Pro Phe Arg Ser Lys Leu 
    130                 135                 140                 


Ala Ala Ala Ile Leu Gly Gly Val Asp Gln Ile His Ile Lys Pro Gly 
145                 150                 155                 160 


Ala Lys Val Leu Tyr Leu Gly Ala Ala Ser Gly Thr Thr Val Ser His 
                165                 170                 175     


Val Ser Asp Ile Val Gly Pro Asp Gly Leu Val Tyr Ala Val Glu Phe 
            180                 185                 190         


Ser His Arg Ser Gly Arg Asp Leu Ile Asn Leu Ala Lys Lys Arg Thr 
        195                 200                 205             


Asn Ile Ile Pro Val Ile Glu Asp Ala Arg His Pro His Lys Tyr Arg 
    210                 215                 220                 


Met Leu Ile Ala Met Val Asp Val Ile Phe Ala Asp Val Ala Gln Pro 
225                 230                 235                 240 


Asp Gln Thr Arg Ile Val Ala Leu Asn Ala His Thr Phe Leu Arg Asn 
                245                 250                 255     


Gly Gly His Phe Val Ile Ser Ile Lys Ala Asn Cys Ile Asp Ser Thr 
            260                 265                 270         


Ala Ser Ala Glu Ala Val Phe Ala Ser Glu Val Lys Lys Met Gln Gln 
        275                 280                 285             


Glu Asn Met Lys Pro Gln Glu Gln Leu Thr Leu Glu Pro Tyr Glu Arg 
    290                 295                 300                 


Asp His Ala Val Val Val Gly Val Tyr Arg Pro Pro Pro Lys Val Lys 
305                 310                 315                 320 


Asn 
    


<210>  1181
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  1181

Met Val Ala Glu Glu Ser Gly Pro Gly Ala Gln Asn Ser Pro Tyr Gln 
1               5                   10                  15      


Leu Arg Arg Lys Thr Leu Leu Pro Lys Arg Thr Ala Cys Pro Thr Lys 
            20                  25                  30          


Asn Ser Met Glu Gly Ala Ser Thr Ser Thr Thr Glu Asn Phe Gly His 
        35                  40                  45              


Arg Ala Lys Arg Ala Arg Val Ser Gly Lys Ser Gln Asp Leu Ser Ala 
    50                  55                  60                  


Ala Pro Ala Glu Gln Tyr Leu Gln Glu Lys Leu Pro Asp Glu Val Val 
65                  70                  75                  80  


Leu Lys Ile Phe Ser Tyr Leu Leu Glu Gln Asp Leu Cys Arg Ala Ala 
                85                  90                  95      


Cys Val Cys Lys Arg Phe Ser Glu Leu Ala Asn Asp Pro Ile Leu Trp 
            100                 105                 110         


Lys Arg Leu Tyr Met Glu Val Phe Glu Tyr Thr Arg Pro Met Met His 
        115                 120                 125             


Pro Glu Pro Gly Lys Phe Tyr Gln Ile Asn Pro Glu Glu Tyr Glu His 
    130                 135                 140                 


Pro Asn Pro Trp Lys Glu Ser Phe Gln Gln Leu Tyr Lys Gly Ala His 
145                 150                 155                 160 


Val Lys Pro Gly Phe Ala Glu His Phe Tyr Ser Asn Pro Ala Arg Tyr 
                165                 170                 175     


Lys Gly Arg Glu Asn Met Leu Tyr Tyr Asp Thr Ile Glu Asp Ala Leu 
            180                 185                 190         


Gly Gly Val Gln Glu Ala His Phe Asp Gly Leu Ile Phe Val His Ser 
        195                 200                 205             


Gly Ile Tyr Thr Asp Glu Trp Ile Tyr Ile Glu Ser Pro Ile Thr Met 
    210                 215                 220                 


Ile Gly Ala Ala Pro Gly Lys Val Ala Asp Lys Val Ile Ile Glu Asn 
225                 230                 235                 240 


Thr Arg Asp Ser Thr Phe Val Phe Met Glu Gly Ser Glu Asp Ala Tyr 
                245                 250                 255     


Val Gly Tyr Met Thr Ile Arg Phe Asn Pro Asp Asp Lys Ser Ala Gln 
            260                 265                 270         


His His Asn Ala His His Cys Leu Glu Ile Thr Val Asn Cys Ser Pro 
        275                 280                 285             


Ile Ile Asp His Cys Ile Ile Arg Ser Thr Cys Thr Val Gly Ser Ala 
    290                 295                 300                 


Val Cys Val Ser Gly Gln Gly Ala Cys Pro Thr Ile Lys His Cys Asn 
305                 310                 315                 320 


Ile Ser Asp Cys Glu Asn Val Gly Leu Tyr Ile Thr Asp His Ala Gln 
                325                 330                 335     


Gly Ile Tyr Glu Asp Asn Glu Ile Ser Asn Asn Ala Leu Ala Gly Ile 
            340                 345                 350         


Trp Val Lys Asn His Gly Asn Pro Ile Ile Arg Arg Asn His Ile His 
        355                 360                 365             


His Gly Arg Asp Val Gly Val Phe Thr Phe Asp His Gly Met Gly Tyr 
    370                 375                 380                 


Phe Glu Ser Cys Asn Ile His Arg Asn Arg Ile Ala Gly Phe Glu Val 
385                 390                 395                 400 


Lys Ala Tyr Ala Asn Pro Thr Val Val Arg Cys Glu Ile His His Gly 
                405                 410                 415     


Gln Thr Gly Gly Ile Tyr Val His Glu Lys Gly Arg Gly Gln Phe Ile 
            420                 425                 430         


Glu Asn Lys Ile Tyr Ala Asn Asn Phe Ala Gly Val Trp Ile Thr Ser 
        435                 440                 445             


Asn Ser Asp Pro Thr Ile Arg Gly Asn Ser Ile Phe Asn Gly Asn Gln 
    450                 455                 460                 


Gly Gly Val Tyr Ile Phe Gly Asp Gly Arg Gly Leu Ile Glu Gly Asn 
465                 470                 475                 480 


Asp Ile Tyr Gly Asn Ala Leu Ala Gly Ile Gln Ile Arg Thr Asn Ser 
                485                 490                 495     


Cys Pro Ile Val Arg His Asn Lys Ile His Asp Gly Gln His Gly Gly 
            500                 505                 510         


Ile Tyr Val His Glu Lys Gly Gln Gly Val Ile Glu Glu Asn Glu Val 
        515                 520                 525             


Tyr Ser Asn Thr Leu Ala Gly Val Trp Val Thr Thr Gly Ser Thr Pro 
    530                 535                 540                 


Val Leu Arg Arg Asn Arg Ile His Ser Gly Lys Gln Val Gly Val Tyr 
545                 550                 555                 560 


Phe Tyr Asp Asn Gly His Gly Val Leu Glu Asp Asn Asp Ile Tyr Asn 
                565                 570                 575     


His Met Tyr Ser Gly Val Gln Ile Arg Thr Gly Ser Asn Pro Lys Ile 
            580                 585                 590         


Arg Arg Asn Lys Ile Trp Gly Gly Gln Asn Gly Gly Ile Leu Val Tyr 
        595                 600                 605             


Asn Ser Gly Leu Gly Cys Ile Glu Asp Asn Glu Ile Phe Asp Asn Ala 
    610                 615                 620                 


Met Ala Gly Val Trp Ile Lys Thr Asp Ser Asn Pro Thr Leu Arg Arg 
625                 630                 635                 640 


Asn Lys Ile His Asp Gly Arg Asp Gly Gly Ile Cys Ile Phe Asn Gly 
                645                 650                 655     


Gly Arg Gly Leu Leu Glu Glu Asn Asp Ile Phe Arg Asn Ala Gln Ala 
            660                 665                 670         


Gly Val Leu Ile Ser Thr Asn Ser His Pro Ile Leu Arg Lys Asn Arg 
        675                 680                 685             


Ile Phe Asp Gly Phe Ala Ala Gly Ile Glu Ile Thr Asn His Ala Thr 
    690                 695                 700                 


Ala Thr Leu Glu Gly Asn Gln Ile Phe Asn Asn Arg Phe Gly Gly Leu 
705                 710                 715                 720 


Phe Leu Ala Ser Gly Val Asn Val Thr Met Lys Asp Asn Lys Ile Met 
                725                 730                 735     


Asn Asn Gln Asp Ala Ile Glu Lys Ala Val Ser Arg Gly Gln Cys Leu 
            740                 745                 750         


Tyr Lys Ile Ser Ser Tyr Thr Ser Tyr Pro Met His Asp Phe Tyr Arg 
        755                 760                 765             


Cys His Thr Cys Asn Thr Thr Asp Arg Asn Ala Ile Cys Val Asn Cys 
    770                 775                 780                 


Ile Lys Lys Cys His Gln Gly His Asp Val Glu Phe Ile Arg His Asp 
785                 790                 795                 800 


Arg Phe Phe Cys Asp Cys Gly Ala Gly Thr Leu Ser Asn Pro Cys Thr 
                805                 810                 815     


Leu Ala Gly Glu Pro Thr His Asp Thr Asp Thr Leu Tyr Asp Ser Ala 
            820                 825                 830         


Pro Pro Ile Glu Ser Asn Thr Leu Gln His Asn 
        835                 840             


<210>  1182
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1182

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  1183
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  1183

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210>  1184
<211>  1269
<212>  PRT
<213>  Homo sapiens

<400>  1184

Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser 
1               5                   10                  15      


Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met 
            20                  25                  30          


Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu 
        35                  40                  45              


Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser 
    50                  55                  60                  


His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val 
                85                  90                  95      


Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser 
            100                 105                 110         


His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn 
        115                 120                 125             


Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile Pro Asn 
    130                 135                 140                 


Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu Ser Glu 
145                 150                 155                 160 


Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg Arg Leu Val His Leu 
                165                 170                 175     


Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu His Ala Gln Leu Arg 
            180                 185                 190         


Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu His Leu Arg Ser Thr 
        195                 200                 205             


Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn 
    210                 215                 220                 


Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu Thr Arg Val Pro Glu 
225                 230                 235                 240 


Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn 
                245                 250                 255     


Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln Trp Val His Val Glu 
            260                 265                 270         


Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile 
        275                 280                 285             


Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu 
    290                 295                 300                 


Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu 
305                 310                 315                 320 


Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu Val Pro Glu Ser Leu 
                325                 330                 335     


Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu Asn Lys Asn His Leu 
            340                 345                 350         


Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr Glu Ile Glu Val Leu 
        355                 360                 365             


Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro Pro Lys Pro Ala Asp 
    370                 375                 380                 


Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu 
385                 390                 395                 400 


Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala Ala Ala Ala Ala Ala 
                405                 410                 415     


Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys Met Arg Leu Arg Arg 
            420                 425                 430         


Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys Gln Val Leu Lys Gly 
        435                 440                 445             


Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys Gln Glu Glu Ser Ala 
    450                 455                 460                 


Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg Trp Asp Gln Gly Leu 
465                 470                 475                 480 


Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe Thr Glu Asp Val Gly 
                485                 490                 495     


Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu Asn Phe Val Pro Val 
            500                 505                 510         


Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr Glu Ala Asp Cys Tyr 
        515                 520                 525             


Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly Ser Leu Asn Trp Glu 
    530                 535                 540                 


Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu Asp Lys Lys Ala Cys 
545                 550                 555                 560 


Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr Leu Gly Ala Glu Cys 
                565                 570                 575     


Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser Glu Glu Phe Leu Gln 
            580                 585                 590         


Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly Gly Thr Ala Ser Gly 
        595                 600                 605             


Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr Arg Met Tyr Arg Val 
    610                 615                 620                 


Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val Pro Leu Lys Gly Thr 
625                 630                 635                 640 


Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp Arg Gly Leu Asp Ile 
                645                 650                 655     


Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser Ser Thr Thr Lys Ala 
            660                 665                 670         


Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu Arg Lys Gly Lys Ala 
        675                 680                 685             


Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu Pro Glu Phe Trp Glu 
    690                 695                 700                 


Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys His Val Pro Glu Asp 
705                 710                 715                 720 


Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val Gly Leu Gly Leu Gly 
                725                 730                 735     


Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu Ser Val Glu His Lys 
            740                 745                 750         


Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met Arg Leu Leu Gln Ser 
        755                 760                 765             


Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp Cys Trp Ser Asp Val 
    770                 775                 780                 


Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu Val Arg Ala Ala Ala 
785                 790                 795                 800 


Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu His Arg Pro Arg His 
                805                 810                 815     


Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu Ala Gln Val Phe Lys 
            820                 825                 830         


Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr Val Asp Tyr Thr Arg 
        835                 840                 845             


Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu Ser Gly Lys Val Lys 
    850                 855                 860                 


Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala Asp Leu Thr Ala Leu 
865                 870                 875                 880 


Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala Glu Ala Glu Gln Leu 
                885                 890                 895     


Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met Glu Gly Phe Val Leu 
            900                 905                 910         


Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu Glu Phe Gly His Phe 
        915                 920                 925             


Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg Tyr Trp Val Pro Val 
    930                 935                 940                 


Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys Glu Glu Lys Ala Glu 
945                 950                 955                 960 


Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala Glu Glu Lys Gln Pro 
                965                 970                 975     


Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp Gln Gly Arg Glu Ala 
            980                 985                 990         


Ser Asn Met Gly Trp Leu Thr Phe  Thr Phe Ser Leu Gln  Lys Lys Phe 
        995                 1000                 1005             


Glu Ser  Leu Phe Pro Gly Lys  Leu Glu Val Val Arg  Met Thr Gln 
    1010                 1015                 1020             


Gln Gln  Glu Asn Pro Lys Phe  Leu Ser His Phe Lys  Arg Lys Phe 
    1025                 1030                 1035             


Ile Ile  His Arg Gly Lys Arg  Lys Ala Val Gln Gly  Ala Gln Gln 
    1040                 1045                 1050             


Pro Ser  Leu Tyr Gln Ile Arg  Thr Asn Gly Ser Ala  Leu Cys Thr 
    1055                 1060                 1065             


Arg Cys  Ile Gln Ile Asn Thr  Asp Ser Ser Leu Leu  Asn Ser Glu 
    1070                 1075                 1080             


Phe Cys  Phe Ile Leu Lys Val  Pro Phe Glu Ser Glu  Asp Asn Gln 
    1085                 1090                 1095             


Gly Ile  Val Tyr Ala Trp Val  Gly Arg Ala Ser Asp  Pro Asp Glu 
    1100                 1105                 1110             


Ala Lys  Leu Ala Glu Asp Ile  Leu Asn Thr Met Phe  Asp Thr Ser 
    1115                 1120                 1125             


Tyr Ser  Lys Gln Val Ile Asn  Glu Gly Glu Glu Pro  Glu Asn Phe 
    1130                 1135                 1140             


Phe Trp  Val Gly Ile Gly Ala  Gln Lys Pro Tyr Asp  Asp Asp Ala 
    1145                 1150                 1155             


Glu Tyr  Met Lys His Thr Arg  Leu Phe Arg Cys Ser  Asn Glu Lys 
    1160                 1165                 1170             


Gly Tyr  Phe Ala Val Thr Glu  Lys Cys Ser Asp Phe  Cys Gln Asp 
    1175                 1180                 1185             


Asp Leu  Ala Asp Asp Asp Ile  Met Leu Leu Asp Asn  Gly Gln Glu 
    1190                 1195                 1200             


Val Tyr  Met Trp Val Gly Thr  Gln Thr Ser Gln Val  Glu Ile Lys 
    1205                 1210                 1215             


Leu Ser  Leu Lys Ala Cys Gln  Val Tyr Ile Gln His  Met Arg Ser 
    1220                 1225                 1230             


Lys Glu  His Glu Arg Pro Arg  Arg Leu Arg Leu Val  Arg Lys Gly 
    1235                 1240                 1245             


Asn Glu  Gln His Ala Phe Thr  Arg Cys Phe His Ala  Trp Ser Ala 
    1250                 1255                 1260             


Phe Cys  Lys Ala Leu Ala 
    1265                 


<210>  1185
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  1185

Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe 
1               5                   10                  15      


Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu 
            20                  25                  30          


Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu 
        35                  40                  45              


Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser 
    50                  55                  60                  


Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met 
65                  70                  75                  80  


Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile 
                85                  90                  95      


Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met 
            100                 105                 110         


Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser 
        115                 120                 125             


Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile 
    130                 135                 140                 


Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr 
145                 150                 155                 160 


Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala 
                165                 170                 175     


Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala 
            180                 185                 190         


Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu 
        195                 200                 205             


Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu 
225                 230                 235                 240 


Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val 
                245                 250                 255     


Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile 
            260                 265                 270         


Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu 
        275                 280                 285             


Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln 
    290                 295                 300                 


Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly 
305                 310                 315                 320 


Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu 
                325                 330                 335     


Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala 
            340                 345                 350         


Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile 
        355                 360                 365             


Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly 
    370                 375                 380                 


Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile 
385                 390                 395                 400 


Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile 
                405                 410                 415     


Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala 
            420                 425         


<210>  1186
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  1186

Met Ala Ala Thr Glu Gly Val Gly Glu Ala Ala Gln Gly Gly Glu Pro 
1               5                   10                  15      


Gly Gln Pro Ala Gln Pro Pro Pro Gln Pro His Pro Pro Pro Pro Gln 
            20                  25                  30          


Gln Gln His Lys Glu Glu Met Ala Ala Glu Ala Gly Glu Ala Val Ala 
        35                  40                  45              


Ser Pro Met Asp Asp Gly Phe Val Ser Leu Asp Ser Pro Ser Tyr Val 
    50                  55                  60                  


Leu Tyr Arg Asp Arg Ala Glu Trp Ala Asp Ile Asp Pro Val Pro Gln 
65                  70                  75                  80  


Asn Asp Gly Pro Asn Pro Val Val Gln Ile Ile Tyr Ser Asp Lys Phe 
                85                  90                  95      


Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu Gln Arg Asp Glu Arg 
            100                 105                 110         


Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala Ile Glu Leu Asn Ala 
        115                 120                 125             


Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val Leu Leu Lys Ser Leu 
    130                 135                 140                 


Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile Thr Ala Ile Ile Glu 
145                 150                 155                 160 


Glu Gln Pro Lys Asn Tyr Gln Val Trp His His Arg Arg Val Leu Val 
                165                 170                 175     


Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu Phe Ile Ala Asp Ile 
            180                 185                 190         


Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp Gln His Arg Gln Trp 
        195                 200                 205             


Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser Val Trp Asn Gln Arg 
225                 230                 235                 240 


Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala Val Leu 
                245                 250                 255     


Glu Arg Glu Val Gln Tyr Thr Leu Glu Met Ile Lys Leu Val Pro His 
            260                 265                 270         


Asn Glu Ser Ala Trp Asn Tyr Leu Lys Gly Ile Leu Gln Asp Arg Gly 
        275                 280                 285             


Leu Ser Lys Tyr Pro Asn Leu Leu Asn Gln Leu Leu Asp Leu Gln Pro 
    290                 295                 300                 


Ser His Ser Ser Pro Tyr Leu Ile Ala Phe Leu Val Asp Ile Tyr Glu 
305                 310                 315                 320 


Asp Met Leu Glu Asn Gln Cys Asp Asn Lys Glu Asp Ile Leu Asn Lys 
                325                 330                 335     


Ala Leu Glu Leu Cys Glu Ile Leu Ala Lys Glu Lys Asp Thr Ile Arg 
            340                 345                 350         


Lys Glu Tyr Trp Arg Tyr Ile Gly Arg Ser Leu Gln Ser Lys His Ser 
        355                 360                 365             


Thr Glu Asn Asp Ser Pro Thr Asn Val Gln Gln 
    370                 375                 


<210>  1187
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  1187

Met Gly Arg Arg Gly Ser Ala Pro Gly Asn Gly Arg Thr Leu Arg Gly 
1               5                   10                  15      


Cys Glu Arg Gly Gly Arg Arg Arg Arg Ser Ala Asp Ser Val Met Ala 
            20                  25                  30          


Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu Arg Glu 
        35                  40                  45              


Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His Ile Phe 
    50                  55                  60                  


Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile Tyr Pro 
65                  70                  75                  80  


Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn Thr Phe 
                85                  90                  95      


Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile Arg Lys 
            100                 105                 110         


Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu Lys Leu 
        115                 120                 125             


Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr Asp Asp 
    130                 135                 140                 


Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu His Leu 
145                 150                 155                 160 


Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro Thr Val 
                165                 170                 175     


Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser Gln Ile 
            180                 185                 190         


Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp Leu Gln 
        195                 200                 205             


Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg Glu Asp 
    210                 215                 220                 


Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val Gln Asn 
225                 230                 235                 240 


Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile Trp Asn 
                245                 250                 255     


Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro Phe Gly 
            260                 265                 270         


Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile Arg Asp 
        275                 280                 285             


Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala Met Glu 
    290                 295                 300                 


Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys Val Lys 
305                 310                 315                 320 


Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val Leu Gly 
                325                 330                 335     


Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys Gly Tyr 
            340                 345                 350         


Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr Phe Ala 
        355                 360                 365             


Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val Pro Phe 
    370                 375                 380                 


Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu Val Arg 
385                 390                 395                 400 


Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln Cys Lys 
                405                 410                 415     


Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val Tyr Thr 
            420                 425                 430         


Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu Glu Ser 
        435                 440                 445             


Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys Leu Pro 
    450                 455                 460                 


Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser Gln Met 
465                 470                 475                 480 


His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile Phe Thr 
                485                 490                 495     


Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile Pro Tyr 
            500                 505                 510         


Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met Lys Arg 
        515                 520                 525             


Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro His Lys 
    530                 535                 540                 


Leu 
545 


<210>  1188
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  1188

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg Leu  Gln Tyr Arg Ser Glu  Thr Met Ala 
    1175                 1180                 1185             


Tyr Lys  Gly Leu Val Trp Ser  Gln Asp Val Thr Gly  Ser Pro Ala 
    1190                 1195                 1200             


<210>  1189
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  1189

Met Ser Gly Ser Ser Ser Val Ala Ala Met Lys Lys Val Val Gln Gln 
1               5                   10                  15      


Leu Arg Leu Glu Ala Gly Leu Asn Arg Val Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Asp Leu Lys Gln Phe Cys Leu Gln Asn Ala Gln His Asp Pro Leu 
        35                  40                  45              


Leu Thr Gly Val Ser Ser Ser Thr Asn Pro Phe Arg Pro Gln Lys Val 
    50                  55                  60                  


Cys Ser Phe Leu 
65              


<210>  1190
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  1190

Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp 
1               5                   10                  15      


Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala 
            20                  25                  30          


Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His 
        35                  40                  45              


Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val 
    50                  55                  60                  


Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala 
65                  70                  75                  80  


Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg 
                85                  90                  95      


Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu 
            100                 105                 110         


Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys 
        115                 120                 125             


Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr 
    130                 135                 140                 


Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser 
145                 150                 155                 160 


Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser 
                165                 170                 175     


Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile 
            180                 185                 190         


Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile 
        195                 200                 205             


Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr 
    210                 215                 220                 


Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala 
225                 230                 235                 240 


Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe 
                245                 250                 255     


Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly 
            260                 265                 270         


Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val 
        275                 280                 285             


Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp 
    290                 295                 300                 


Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu 
305                 310                 315                 320 


Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His 
                325                 330                 335     


Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe 
            340                 345                 350         


Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly 
        355                 360                 365             


Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly 
    370                 375                 380                 


Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys 
385                 390                 395                 400 


Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile 
                405                 410                 415     


Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln 
            420                 425                 430         


Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu 
        435                 440                 445             


Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro 
    450                 455                 460                 


His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr 
465                 470                 475                 480 


Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His 
                485                 490                 495     


Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln 
            500                 505                 510         


Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu 
        515                 520                 525             


Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly 
    530                 535                 540                 


Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln 
545                 550                 555             


<210>  1191
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  1191

Met Ser His Glu Lys Ser Phe Leu Val Ser Gly Asp Asn Tyr Pro Pro 
1               5                   10                  15      


Pro Asn Pro Gly Tyr Pro Gly Gly Pro Gln Pro Pro Met Pro Pro Tyr 
            20                  25                  30          


Ala Gln Pro Pro Tyr Pro Gly Ala Pro Tyr Pro Gln Pro Pro Phe Gln 
        35                  40                  45              


Pro Ser Pro Tyr Gly Gln Pro Gly Tyr Pro His Gly Pro Ser Pro Tyr 
    50                  55                  60                  


Pro Gln Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Gly Gly Tyr Pro 
65                  70                  75                  80  


Gln Gly Pro Tyr Pro Gln Glu Gly Tyr Pro Gln Gly Pro Tyr Pro Gln 
                85                  90                  95      


Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Ser Pro Phe Pro Pro Asn 
            100                 105                 110         


Pro Tyr Gly Gln Pro Gln Val Phe Pro Gly Gln Asp Pro Asp Ser Pro 
        115                 120                 125             


Gln His Gly Asn Tyr Gln Glu Glu Gly Pro Pro Ser Tyr Tyr Asp Asn 
    130                 135                 140                 


Gln Asp Phe Pro Ala Thr Asn Trp Asp Asp Lys Ser Ile Arg Gln Ala 
145                 150                 155                 160 


Phe Ile Arg Lys Val Phe Leu Val Leu Thr Leu Gln Leu Ser Val Thr 
                165                 170                 175     


Leu Ser Thr Val Ser Val Phe Thr Phe Val Ala Glu Val Lys Gly Phe 
            180                 185                 190         


Val Arg Glu Asn Val Trp Thr Tyr Tyr Val Ser Tyr Ala Val Phe Phe 
        195                 200                 205             


Ile Ser Leu Ile Val Leu Ser Cys Cys Gly Asp Phe Arg Arg Lys His 
    210                 215                 220                 


Pro Trp Asn Leu Val Ala Leu Ser Val Leu Thr Ala Ser Leu Ser Tyr 
225                 230                 235                 240 


Met Val Gly Met Ile Ala Ser Phe Tyr Asn Thr Glu Ala Val Ile Met 
                245                 250                 255     


Ala Val Gly Ile Thr Thr Ala Val Cys Phe Thr Val Val Ile Phe Ser 
            260                 265                 270         


Met Gln Thr Arg Tyr Asp Phe Thr Ser Cys Met Gly Val Leu Leu Val 
        275                 280                 285             


Ser Met Val Val Leu Phe Ile Phe Ala Ile Leu Cys Ile Phe Ile Arg 
    290                 295                 300                 


Asn Arg Ile Leu Glu Ile Val Tyr Ala Ser Leu Gly Ala Leu Leu Phe 
305                 310                 315                 320 


Thr Cys Phe Leu Ala Val Asp Thr Gln Leu Leu Leu Gly Asn Lys Gln 
                325                 330                 335     


Leu Ser Leu Ser Pro Glu Glu Tyr Val Phe Ala Ala Leu Asn Leu Tyr 
            340                 345                 350         


Thr Asp Ile Ile Asn Ile Phe Leu Tyr Ile Leu Thr Ile Ile Gly Arg 
        355                 360                 365             


Ala Lys Glu 
    370     


<210>  1192
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  1192

Leu Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp 
65                  70                  75                  80  


Ile Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp 
                85                  90                  95      


Leu Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly 
            100                 105                 110         


Glu Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp 
    130                 135                 140                 


Phe Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala 
145                 150                 155                 160 


Pro Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly 
            180                 185                 190         


Asp Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe 
        195                 200                 205             


Tyr Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp 
    210                 215                 220                 


His Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro 
225                 230                 235                 240 


Cys Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu 
                245                 250                 255     


Ile Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln 
            260                 265                 270         


Phe Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala 
        275                 280                 285             


Val Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala 
    290                 295                 300                 


Glu Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu 
305                 310                 315                 320 


His Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met 
                325                 330                 335     


Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys 
            340                 345                 350         


Gln Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly 
        355                 360                 365             


Met Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala 
    370                 375                 380                 


Ala Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe 
385                 390                 395                 400 


Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly 
                405                 410                 415     


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly 
            420                 425                 430         


Ser Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met 
        435                 440                 445             


Glu Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro 
    450                 455                 460                 


Glu Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu 
465                 470                 475                 480 


Asn Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn 
                485                 490                 495     


Arg Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp 
            500                 505                 510         


Asp Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 525     


<210>  1193
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  1193

Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser 
        355                 360                 365             


Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln 
    370                 375                 380                 


Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His 
385                 390                 395                 400 


Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys 
                405                 410                 415     


Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser 
            420                 425                 430         


Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr 
        435                 440                 445             


Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp 
    450                 455                 460                 


Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser 
465                 470                 475                 480 


Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn 
                485                 490                 495     


Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser 
            500                 505                 510         


Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu 
        515                 520                 525             


Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser 
    530                 535                 540                 


Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys 
545                 550                 555                 560 


Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn 
                565                 570                 575     


Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu 
            580                 585                 590         


Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Asp Asn His 
        595                 600                 605             


Leu Ile Pro Ala Glu Thr Pro Ser Pro Val Ile Phe Ser Asp Phe Pro 
    610                 615                 620                 


Phe Ile Phe Asn Ser Leu Ser Lys Ile Lys Leu Leu Gln Ala Asp Ser 
625                 630                 635                 640 


His Ile Lys Met Gln Met Ser Glu Lys Lys Ala Tyr Met Leu Met His 
                645                 650                 655     


Glu Thr Ile Leu Gln Lys Lys Asp Glu Phe Pro Pro Ser Pro Arg Phe 
            660                 665                 670         


Ile Leu Arg Val Arg Arg Ser Arg Leu Val Lys Asp Ala Leu Arg Gln 
        675                 680                 685             


Leu Ser Gln Ala Glu Ala Thr Asp Phe Cys Lys Val Leu Val Val Glu 
    690                 695                 700                 


Phe Ile Asn Glu Ile Cys Pro Glu Ser Gly Gly Val Ser Ser Glu Phe 
705                 710                 715                 720 


Phe His Cys Met Phe Glu Glu Met Thr Lys Pro Glu Tyr Gly Met Phe 
                725                 730                 735     


Met Tyr Pro Glu Met Gly Ser Cys Met Trp Phe Pro Ala Lys Pro Lys 
            740                 745                 750         


Pro Glu Lys Lys Arg Tyr Phe Leu Phe Gly Met Leu Cys Gly Leu Ser 
        755                 760                 765             


Leu Phe Asn Leu Asn Val Ala Asn Leu Pro Phe Pro Leu Ala Leu Tyr 
    770                 775                 780                 


Lys Lys Leu Leu Asp Gln Lys Pro Ser Leu Glu Asp Leu Lys Glu Leu 
785                 790                 795                 800 


Ser Pro Arg Leu Gly Lys Ser Leu Gln Glu Val Leu Asp Asp Ala Ala 
                805                 810                 815     


Asp Asp Ile Gly Asp Ala Leu Cys Ile Arg Phe Ser Ile His Trp Asp 
            820                 825                 830         


Gln Asn Asp Val Asp Leu Ile Pro Asn Gly Ile Ser Ile Pro Val Asp 
        835                 840                 845             


Gln Thr Asn Lys Arg Asp Tyr Val Ser Lys Tyr Ile Asp Tyr Ile Phe 
    850                 855                 860                 


Asn Val Ser Val Lys Ala Val Tyr Glu Glu Phe Gln Arg Gly Phe Tyr 
865                 870                 875                 880 


Arg Val Cys Glu Lys Glu Ile Leu Arg His Phe Tyr Pro Glu Glu Leu 
                885                 890                 895     


Met Thr Ala Ile Ile Gly Asn Thr Asp Tyr Asp Trp Lys Gln Phe Glu 
            900                 905                 910         


Gln Asn Ser Lys Tyr Glu Gln Gly Tyr Gln Lys Ser His Pro Thr Ile 
        915                 920                 925             


Gln Leu Phe Trp Lys Ala Phe His Lys Leu Thr Leu Asp Glu Lys Lys 
    930                 935                 940                 


Lys Phe Leu Phe Phe Leu Thr Gly Arg Asp Arg Leu His Ala Arg Gly 
945                 950                 955                 960 


Ile Gln Lys Met Glu Ile Val Phe Arg Cys Pro Glu Thr Phe Ser Glu 
                965                 970                 975     


Arg Asp His Pro Thr Ser Ile Thr Cys His Asn Ile Leu Ser Leu Pro 
            980                 985                 990         


Lys Tyr Ser Thr Met Glu Arg Met  Glu Glu Ala Leu Gln  Val Ala Ile 
        995                 1000                 1005             


Asn Asn  Asn Arg Gly Phe Val  Ser Pro Met Leu Thr  Gln Ser 
    1010                 1015                 1020         


<210>  1194
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  1194

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  1195
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  1195

Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210>  1196
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  1196

Met Val Arg Lys Leu Lys Phe His Glu Gln Lys Leu Leu Lys Gln Val 
1               5                   10                  15      


Asp Phe Leu Asn Trp Glu Val Thr Asp His Asn Leu His Glu Leu Arg 
            20                  25                  30          


Val Leu Arg Arg Tyr Arg Leu Gln Arg Arg Glu Asp Tyr Thr Arg Tyr 
        35                  40                  45              


Asn Gln Leu Ser Arg Ala Val Arg Glu Leu Ala Arg Arg Leu Arg Asp 
    50                  55                  60                  


Leu Pro Glu Arg Asp Gln Phe Arg Val Arg Ala Ser Ala Ala Leu Leu 
65                  70                  75                  80  


Asp Lys Leu Tyr Ala Leu Gly Leu Val Pro Thr Arg Gly Ser Leu Glu 
                85                  90                  95      


Leu Cys Asp Phe Val Thr Ala Ser Ser Phe Cys Arg Arg Arg Leu Pro 
            100                 105                 110         


Thr Val Leu Leu Lys Leu Arg Met Ala Gln His Leu Gln Ala Ala Val 
        115                 120                 125             


Ala Phe Val Glu Gln Gly His Val Arg Val Gly Pro Asp Val Val Thr 
    130                 135                 140                 


Asp Pro Ala Phe Leu Val Thr Arg Ser Met Glu Asp Phe Val Thr Trp 
145                 150                 155                 160 


Val Asp Ser Ser Lys Ile Lys Arg His Val Leu Glu Tyr Asn Glu Glu 
                165                 170                 175     


Arg Asp Asp Phe Asp Leu Glu Ala 
            180                 


<210>  1197
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  1197

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
        195                 200                 205             


Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
225                 230                 235                 240 


Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                245                 250                 255     


Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
            260                 265                 270         


Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
        275                 280                 285             


Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
    290                 295                 300                 


Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
305                 310                 315                 320 


Ile Pro Cys Ala Pro 
                325 


<210>  1198
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1198

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
        115                 120                 125             


Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
    130                 135                 140                 


Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys 
145                 150                 155                 160 


Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp 
                165                 170                 175     


Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr 
            180                 185                 190         


Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser 
        195                 200                 205             


Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro 
    210                 215                 220                 


Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys 
225                 230                 235                 240 


Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp 
                245                 250                 255     


Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly 
            260                 265                 270         


His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe 
        275                 280                 285             


Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val 
    290                 295                 300                 


Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln 
305                 310                 315                 320 


Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn 
                325                 330                 335     


Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu Cys Phe Gly Glu 
            340                 345                 350         


Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu Ile Leu Val Gln 
        355                 360                 365             


Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser 
    370                 375                 380                 


Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu Pro Pro Pro Asp 
385                 390                 395                 400 


Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser His Gln Arg Ser 
                405                 410                 415     


Phe Phe Arg Glu Asn Gln Gln Ile Thr Val 
            420                 425     


<210>  1199
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  1199

Met Cys Thr Lys Met Glu Gln Pro Phe Tyr His Asp Asp Ser Tyr Thr 
1               5                   10                  15      


Ala Thr Gly Tyr Gly Arg Ala Pro Gly Gly Leu Ser Leu His Asp Tyr 
            20                  25                  30          


Lys Leu Leu Lys Pro Ser Leu Ala Val Asn Leu Ala Asp Pro Tyr Arg 
        35                  40                  45              


Ser Leu Lys Ala Pro Gly Ala Arg Gly Pro Gly Pro Glu Gly Gly Gly 
    50                  55                  60                  


Gly Gly Ser Tyr Phe Ser Gly Gln Gly Ser Asp Thr Gly Ala Ser Leu 
65                  70                  75                  80  


Lys Leu Ala Ser Ser Glu Leu Glu Arg Leu Ile Val Pro Asn Ser Asn 
                85                  90                  95      


Gly Val Ile Thr Thr Thr Pro Thr Pro Pro Gly Gln Tyr Phe Tyr Pro 
            100                 105                 110         


Arg Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Val 
        115                 120                 125             


Thr Glu Glu Gln Glu Gly Phe Ala Asp Gly Phe Val Lys Ala Leu Asp 
    130                 135                 140                 


Asp Leu His Lys Met Asn His Val Thr Pro Pro Asn Val Ser Leu Gly 
145                 150                 155                 160 


Ala Thr Gly Gly Pro Pro Ala Gly Pro Gly Gly Val Tyr Ala Gly Pro 
                165                 170                 175     


Glu Pro Pro Pro Val Tyr Thr Asn Leu Ser Ser Tyr Ser Pro Ala Ser 
            180                 185                 190         


Ala Ser Ser Gly Gly Ala Gly Ala Ala Val Gly Thr Gly Ser Ser Tyr 
        195                 200                 205             


Pro Thr Thr Thr Ile Ser Tyr Leu Pro His Ala Pro Pro Phe Ala Gly 
    210                 215                 220                 


Gly His Pro Ala Gln Leu Gly Leu Gly Arg Gly Ala Ser Thr Phe Lys 
225                 230                 235                 240 


Glu Glu Pro Gln Thr Val Pro Glu Ala Arg Ser Arg Asp Ala Thr Pro 
                245                 250                 255     


Pro Val Ser Pro Ile Asn Met Glu Asp Gln Glu Arg Ile Lys Val Glu 
            260                 265                 270         


Arg Lys Arg Leu Arg Asn Arg Leu Ala Ala Thr Lys Cys Arg Lys Arg 
        275                 280                 285             


Lys Leu Glu Arg Ile Ala Arg Leu Glu Asp Lys Val Lys Thr Leu Lys 
    290                 295                 300                 


Ala Glu Asn Ala Gly Leu Ser Ser Thr Ala Gly Leu Leu Arg Glu Gln 
305                 310                 315                 320 


Val Ala Gln Leu Lys Gln Lys Val Met Thr His Val Ser Asn Gly Cys 
                325                 330                 335     


Gln Leu Leu Leu Gly Val Lys Gly His Ala Phe 
            340                 345         


<210>  1200
<211>  1770
<212>  PRT
<213>  Homo sapiens

<400>  1200

Met Ser Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ser Arg Glu Thr Ser Lys Glu Ser Lys Cys Ile Ile Gln Met Gln Gly 
            20                  25                  30          


Asn Ser Thr Ser Ile Ile Asn Pro Lys Asn Pro Lys Glu Ala Pro Lys 
        35                  40                  45              


Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp 
    50                  55                  60                  


Pro Cys Phe Ala Ser Gln Asn Arg Val Tyr Asn Asp Ile Gly Lys Glu 
65                  70                  75                  80  


Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu 
            100                 105                 110         


Glu Ser Gln Ala Gly Ile Ile Pro Gln Leu Cys Glu Glu Leu Phe Glu 
        115                 120                 125             


Lys Ile Asn Asp Asn Cys Asn Glu Glu Met Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Asn Lys Gly Asn Leu Arg Val Arg Glu His Pro Leu Leu Gly Pro 
                165                 170                 175     


Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Thr Asp Ile 
            180                 185                 190         


Ala Asp Leu Met Asp Ala Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Thr Ile Val 
    210                 215                 220                 


Phe Thr Gln Lys Lys His Asp Asn Glu Thr Asn Leu Ser Thr Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Val 
        275                 280                 285             


Ser Lys Lys Lys Lys Lys Thr Asp Phe Ile Pro Tyr Arg Asp Ser Val 
    290                 295                 300                 


Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala 
305                 310                 315                 320 


Met Val Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Asp Glu Thr Leu 
                325                 330                 335     


Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Gln Ile Lys Cys Asn Ala 
            340                 345                 350         


Val Ile Asn Glu Asp Pro Asn Ala Lys Leu Val Arg Glu Leu Lys Glu 
        355                 360                 365             


Glu Val Thr Arg Leu Lys Asp Leu Leu Arg Ala Gln Gly Leu Gly Asp 
    370                 375                 380                 


Ile Ile Asp Thr Ser Met Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys 
385                 390                 395                 400 


Ser Leu Ser Ser Gln Val Gly Leu Thr Ser Val Thr Ser Ile Gln Glu 
                405                 410                 415     


Arg Ile Met Ser Thr Pro Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys 
            420                 425                 430         


Glu Ser Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys 
        435                 440                 445             


Leu Arg Lys Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala 
    450                 455                 460                 


Glu Met Gly Val Ala Ile Arg Glu Asp Gly Gly Thr Leu Gly Val Phe 
465                 470                 475                 480 


Ser Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu 
                485                 490                 495     


Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val 
            500                 505                 510         


Gly Gln Ala Asp Ala Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala 
        515                 520                 525             


His Ile Lys Glu Glu His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser 
    530                 535                 540                 


Gly Glu Val Ile Val Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr 
545                 550                 555                 560 


Val Asn Gly Lys Arg Val Ser Gln Pro Val Gln Leu Arg Ser Gly Asn 
                565                 570                 575     


Arg Ile Ile Met Gly Lys Asn His Val Phe Arg Phe Asn His Pro Glu 
            580                 585                 590         


Gln Ala Arg Ala Glu Arg Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser 
        595                 600                 605             


Glu Pro Val Asp Trp Thr Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln 
    610                 615                 620                 


Gly Ile Asp Met Lys Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu 
625                 630                 635                 640 


Ile Leu Tyr Lys Lys Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln 
                645                 650                 655     


Gln Arg Leu Asp Tyr Glu Ser Lys Leu Gln Ala Leu Gln Lys Gln Val 
            660                 665                 670         


Glu Thr Arg Ser Leu Ala Ala Glu Thr Thr Glu Glu Glu Glu Glu Glu 
        675                 680                 685             


Glu Glu Val Pro Trp Thr Gln His Glu Phe Glu Leu Ala Gln Trp Ala 
    690                 695                 700                 


Phe Arg Lys Trp Lys Ser His Gln Phe Thr Ser Leu Arg Asp Leu Leu 
705                 710                 715                 720 


Trp Gly Asn Ala Val Tyr Leu Lys Glu Ala Asn Ala Ile Ser Val Glu 
                725                 730                 735     


Leu Lys Lys Lys Val Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu 
            740                 745                 750         


Tyr Ser Pro Leu Pro Pro Glu Leu Leu Pro Thr Glu Met Glu Lys Thr 
        755                 760                 765             


His Glu Asp Arg Pro Phe Pro Arg Thr Val Val Ala Val Glu Val Gln 
    770                 775                 780                 


Asp Leu Lys Asn Gly Ala Thr His Tyr Trp Ser Leu Glu Lys Leu Lys 
785                 790                 795                 800 


Gln Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Gly Glu Met 
                805                 810                 815     


Ala Ser Ser Ala Gln Asp Glu Ser Glu Thr Thr Val Thr Gly Ser Asp 
            820                 825                 830         


Pro Phe Tyr Asp Arg Phe His Trp Phe Lys Leu Val Gly Ser Ser Pro 
        835                 840                 845             


Ile Phe His Gly Cys Val Asn Glu Arg Leu Ala Asp Arg Thr Pro Ser 
    850                 855                 860                 


Pro Thr Phe Ser Thr Ala Asp Ser Asp Ile Thr Glu Leu Ala Asp Glu 
865                 870                 875                 880 


Gln Gln Asp Glu Met Glu Asp Phe Asp Asp Glu Ala Phe Val Asp Asp 
                885                 890                 895     


Ala Gly Ser Asp Ala Gly Thr Glu Glu Gly Ser Asp Leu Phe Ser Asp 
            900                 905                 910         


Gly His Asp Pro Phe Tyr Asp Arg Ser Pro Trp Phe Ile Leu Val Gly 
        915                 920                 925             


Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val Pro Leu Ile 
    930                 935                 940                 


His Arg Val Ala Ile Val Ser Glu Lys Gly Glu Val Arg Gly Phe Leu 
945                 950                 955                 960 


Arg Val Ala Val Gln Ala Ile Ala Ala Asp Glu Glu Ala Pro Asp Tyr 
                965                 970                 975     


Gly Ser Gly Ile Arg Gln Ser Gly Thr Ala Lys Ile Ser Phe Asp Asn 
            980                 985                 990         


Glu Tyr Phe Asn Gln Ser Asp Phe  Ser Ser Val Ala Met  Thr Arg Ser 
        995                 1000                 1005             


Gly Leu  Ser Leu Glu Glu Leu  Arg Ile Val Glu Gly  Gln Gly Gln 
    1010                 1015                 1020             


Ser Ser  Glu Val Ile Thr Pro  Pro Glu Glu Ile Ser  Arg Ile Asn 
    1025                 1030                 1035             


Asp Leu  Asp Leu Lys Ser Ser  Thr Leu Leu Asp Gly  Lys Met Val 
    1040                 1045                 1050             


Met Glu  Gly Phe Ser Glu Glu  Ile Gly Asn His Leu  Lys Leu Gly 
    1055                 1060                 1065             


Ser Ala  Phe Thr Phe Arg Val  Thr Val Leu Gln Ala  Ser Gly Ile 
    1070                 1075                 1080             


Leu Pro  Glu Tyr Ala Asp Ile  Phe Cys Gln Phe Asn  Phe Leu His 
    1085                 1090                 1095             


Arg His  Asp Glu Ala Phe Ser  Thr Glu Pro Leu Lys  Asn Asn Gly 
    1100                 1105                 1110             


Arg Gly  Ser Pro Leu Ala Phe  Tyr His Val Gln Asn  Ile Ala Val 
    1115                 1120                 1125             


Glu Ile  Thr Glu Ser Phe Val  Asp Tyr Ile Lys Thr  Lys Pro Ile 
    1130                 1135                 1140             


Val Phe  Glu Val Phe Gly His  Tyr Gln Gln His Pro  Leu His Leu 
    1145                 1150                 1155             


Gln Gly  Gln Glu Leu Asn Ser  Pro Pro Gln Pro Cys  Arg Arg Phe 
    1160                 1165                 1170             


Phe Pro  Pro Pro Met Pro Leu  Ser Lys Pro Val Pro  Ala Thr Lys 
    1175                 1180                 1185             


Leu Asn  Thr Met Ser Lys Thr  Ser Leu Gly Gln Ser  Met Ser Lys 
    1190                 1195                 1200             


Tyr Asp  Leu Leu Val Trp Phe  Glu Ile Ser Glu Leu  Glu Pro Thr 
    1205                 1210                 1215             


Gly Glu  Tyr Ile Pro Ala Val  Val Asp His Thr Ala  Gly Leu Pro 
    1220                 1225                 1230             


Cys Gln  Gly Thr Phe Leu Leu  His Gln Gly Ile Gln  Arg Arg Ile 
    1235                 1240                 1245             


Thr Val  Thr Ile Ile His Glu  Lys Gly Ser Glu Leu  His Trp Lys 
    1250                 1255                 1260             


Asp Val  Arg Glu Leu Val Val  Gly Arg Ile Arg Asn  Lys Pro Glu 
    1265                 1270                 1275             


Val Asp  Glu Ala Ala Val Asp  Ala Ile Leu Ser Leu  Asn Ile Ile 
    1280                 1285                 1290             


Ser Ala  Lys Tyr Leu Lys Ser  Ser His Asn Ser Ser  Arg Thr Phe 
    1295                 1300                 1305             


Tyr Arg  Phe Glu Ala Val Trp  Asp Ser Ser Leu His  Asn Ser Leu 
    1310                 1315                 1320             


Leu Leu  Asn Arg Val Thr Pro  Tyr Gly Glu Lys Ile  Tyr Met Thr 
    1325                 1330                 1335             


Leu Ser  Ala Tyr Leu Glu Leu  Asp His Cys Ile Gln  Pro Ala Val 
    1340                 1345                 1350             


Ile Thr  Lys Asp Val Cys Met  Val Phe Tyr Ser Arg  Asp Ala Lys 
    1355                 1360                 1365             


Ile Ser  Pro Pro Arg Ser Leu  Arg Ser Leu Phe Gly  Ser Gly Tyr 
    1370                 1375                 1380             


Ser Lys  Ser Pro Asp Ser Asn  Arg Val Thr Gly Ile  Tyr Glu Leu 
    1385                 1390                 1395             


Ser Leu  Cys Lys Met Ser Asp  Thr Gly Ser Pro Gly  Met Gln Arg 
    1400                 1405                 1410             


Arg Arg  Arg Lys Ile Leu Asp  Thr Ser Val Ala Tyr  Val Arg Gly 
    1415                 1420                 1425             


Glu Glu  Asn Leu Ala Gly Trp  Arg Pro Arg Gly Asp  Ser Leu Ile 
    1430                 1435                 1440             


Leu Glu  His Gln Trp Glu Leu  Glu Lys Leu Glu Leu  Leu His Glu 
    1445                 1450                 1455             


Val Glu  Lys Thr Arg His Phe  Leu Leu Leu Arg Glu  Arg Leu Gly 
    1460                 1465                 1470             


Asp Ser  Ile Pro Lys Ser Leu  Ser Asp Ser Leu Ser  Pro Ser Leu 
    1475                 1480                 1485             


Ser Ser  Gly Thr Leu Ser Thr  Ser Thr Ser Ile Ser  Ser Gln Ile 
    1490                 1495                 1500             


Ser Thr  Thr Thr Phe Glu Ser  Ala Ile Thr Pro Ser  Glu Ser Ser 
    1505                 1510                 1515             


Gly Tyr  Asp Ser Gly Asp Ile  Glu Ser Leu Val Asp  Arg Glu Lys 
    1520                 1525                 1530             


Glu Leu  Ala Thr Lys Cys Leu  Gln Leu Leu Thr His  Thr Phe Asn 
    1535                 1540                 1545             


Arg Glu  Phe Ser Gln Val His  Gly Ser Val Ser Asp  Cys Lys Leu 
    1550                 1555                 1560             


Ser Asp  Ile Ser Pro Ile Gly  Arg Asp Pro Ser Glu  Ser Ser Phe 
    1565                 1570                 1575             


Ser Ser  Ala Thr Leu Thr Pro  Ser Ser Thr Cys Pro  Ser Leu Val 
    1580                 1585                 1590             


Asp Ser  Arg Ser Asn Ser Leu  Asp Gln Lys Thr Pro  Glu Ala Asn 
    1595                 1600                 1605             


Ser Arg  Ala Ser Ser Pro Cys  Pro Glu Phe Glu Gln  Phe Gln Ile 
    1610                 1615                 1620             


Val Pro  Ala Val Glu Thr Pro  Tyr Leu Ala Arg Ala  Gly Lys Asn 
    1625                 1630                 1635             


Glu Phe  Leu Asn Leu Val Pro  Asp Ile Glu Glu Ile  Arg Pro Ser 
    1640                 1645                 1650             


Ser Val  Val Ser Lys Lys Gly  Tyr Leu His Phe Lys  Glu Pro Leu 
    1655                 1660                 1665             


Tyr Ser  Asn Trp Ala Lys His  Phe Val Val Val Arg  Arg Pro Tyr 
    1670                 1675                 1680             


Val Phe  Ile Tyr Asn Ser Asp  Lys Asp Pro Val Glu  Arg Gly Ile 
    1685                 1690                 1695             


Ile Asn  Leu Ser Thr Ala Gln  Val Glu Tyr Ser Glu  Asp Gln Gln 
    1700                 1705                 1710             


Ala Met  Val Lys Thr Pro Asn  Thr Phe Ala Val Cys  Thr Lys His 
    1715                 1720                 1725             


Arg Gly  Val Leu Leu Gln Ala  Leu Asn Asp Lys Asp  Met Asn Asp 
    1730                 1735                 1740             


Trp Leu  Tyr Ala Phe Asn Pro  Leu Leu Ala Gly Thr  Ile Arg Ser 
    1745                 1750                 1755             


Lys Leu  Ser Arg Arg Cys Pro  Ser Gln Ser Lys Tyr  
    1760                 1765                 1770 


<210>  1201
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  1201

Met Phe Leu Leu Pro Leu Pro Ala Ala Gly Arg Val Val Val Arg Arg 
1               5                   10                  15      


Leu Ala Val Arg Arg Phe Gly Ser Arg Ser Leu Ser Thr Ala Asp Met 
            20                  25                  30          


Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp Asp 
        35                  40                  45              


Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu Ala 
    50                  55                  60                  


Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys Ala 
65                  70                  75                  80  


Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser Val 
                85                  90                  95      


Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln Glu 
            100                 105                 110         


Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala Gly 
        115                 120                 125             


Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp Pro 
    130                 135                 140                 


Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu Tyr 
145                 150                 155                 160 


Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala Lys 
                165                 170                 175     


Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu Phe 
            180                 185                 190         


Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala Asn 
        195                 200                 205             


Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu Lys 
    210                 215                 220                 


Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp Ile 
225                 230                 235                 240 


Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser Asp 
                245                 250                 255     


Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn Ala 
            260                 265                 270         


Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp Ser 
        275                 280                 285             


Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg Ala 
    290                 295                 300                 


Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys Glu 
                325                 330                 335     


Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg Ala 
            340                 345                 350         


Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly Arg 
        355                 360                 365             


Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro Lys 
    370                 375                 380                 


Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala Leu 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp Asn 
                405                 410                 415     


Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg Met 
            420                 425                 430         


Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu Ala 
        435                 440                 445             


Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr Ala 
    450                 455                 460                 


Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His Leu 
465                 470                 475                 480 


Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu Arg 
                485                 490                 495     


Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu Leu 
            500                 505                 510         


Arg Phe Ser Gln Asp Asn Ala 
        515                 


<210>  1202
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  1202

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  1203
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  1203

Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe 
1               5                   10                  15      


Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu 
            20                  25                  30          


Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys 
        35                  40                  45              


Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr 
    50                  55                  60                  


Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp 
65                  70                  75                  80  


Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val 
                85                  90                  95      


Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp 
            100                 105                 110         


Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser 
        115                 120                 125             


Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu 
    130                 135                 140                 


Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln Val Thr 
145                 150                 155                 160 


Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu 
                165                 170                 175     


Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr 
            180                 185                 190         


Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr 
        195                 200                 205             


Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala 
    210                 215                 220                 


Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln 
225                 230                 235                 240 


Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Gly Thr Thr Gly Glu Thr 
                245                 250                 255     


Val Val Gly Val Leu Gly Glu Pro Val Thr Leu Pro Leu Ala Leu Pro 
            260                 265                 270         


Ala Cys Arg Asp Thr Glu Lys Val Val Trp Leu Phe Asn Thr Ser Ile 
        275                 280                 285             


Ile Ser Lys Glu Arg Glu Glu Ala Ala Thr Ala Asp Pro Leu Ile Lys 
    290                 295                 300                 


Ser Arg Asp Pro Tyr Lys Asn Arg Val Trp Val Ser Ser Gln Asp Cys 
305                 310                 315                 320 


Ser Leu Lys Ile Ser Gln Leu Lys Ile Glu Asp Ala Gly Pro Tyr His 
                325                 330                 335     


Ala Tyr Val Cys Ser Glu Ala Ser Ser Val Thr Ser Met Thr His Val 
            340                 345                 350         


Thr Leu Leu Ile Tyr Arg Arg Leu Arg Lys Pro Lys Ile Thr Trp Ser 
        355                 360                 365             


Leu Arg His Ser Glu Asp Gly Ile Cys Arg Ile Ser Leu Thr Cys Ser 
    370                 375                 380                 


Val Glu Asp Gly Gly Asn Thr Val Met Tyr Thr Trp Thr Pro Leu Gln 
385                 390                 395                 400 


Lys Glu Ala Val Val Ser Gln Gly Glu Ser His Leu Asn Val Ser Trp 
                405                 410                 415     


Arg Ser Ser Glu Asn His Pro Asn Leu Thr Cys Thr Ala Ser Asn Pro 
            420                 425                 430         


Val Ser Arg Ser Ser His Gln Phe Leu Ser Glu Asn Ile Cys Ser Gly 
        435                 440                 445             


Pro Glu Arg Asn Thr Lys Leu Trp Ile Gly Leu Phe Leu Met Val Cys 
    450                 455                 460                 


Leu Leu Cys Val Gly Ile Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly 
465                 470                 475                 480 


Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala 
                485                 490                 495     


Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser 
            500                 505                 510         


Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln 
        515                 520                 525             


Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu 
    530                 535                 540                 


Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr 
545                 550                 555                 560 


Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala 
                565                 570                 575     


Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu 
            580                 585                 590         


Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn 
        595                 600                 605             


Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr 
    610                 615                 620                 


Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln 
625                 630                 635                 640 


Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
                645                 650                 655 


<210>  1204
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  1204

Met Ala Ala Val Glu Thr Arg Val Cys Glu Thr Asp Gly Cys Ser Ser 
1               5                   10                  15      


Glu Ala Lys Leu Gln Cys Pro Thr Cys Ile Lys Leu Gly Ile Gln Gly 
            20                  25                  30          


Ser Tyr Phe Cys Ser Gln Glu Cys Phe Lys Gly Ser Trp Ala Thr His 
        35                  40                  45              


Lys Leu Leu His Lys Lys Ala Lys Asp Glu Lys Ala Lys Arg Glu Val 
    50                  55                  60                  


Ser Ser Trp Thr Val Glu Gly Asp Ile Asn Thr Asp Pro Trp Ala Gly 
65                  70                  75                  80  


Tyr Arg Tyr Thr Gly Lys Leu Arg Pro His Tyr Pro Leu Met Pro Thr 
                85                  90                  95      


Arg Pro Val Pro Ser Tyr Ile Gln Arg Pro Asp Tyr Ala Asp His Pro 
            100                 105                 110         


Leu Gly Met Ser Glu Ser Glu Gln Ala Leu Lys Gly Thr Ser Gln Ile 
        115                 120                 125             


Lys Leu Leu Ser Ser Glu Asp Ile Glu Gly Met Arg Leu Val Cys Arg 
    130                 135                 140                 


Leu Ala Arg Glu Val Leu Asp Val Ala Ala Gly Met Ile Lys Pro Gly 
145                 150                 155                 160 


Val Thr Thr Glu Glu Ile Asp His Ala Val His Leu Ala Cys Ile Ala 
                165                 170                 175     


Arg Asn Cys Tyr Pro Ser Pro Leu Asn Tyr Tyr Asn Phe Pro Lys Ser 
            180                 185                 190         


Cys Cys Thr Ser Val Asn Glu Val Ile Cys His Gly Ile Pro Asp Arg 
        195                 200                 205             


Arg Pro Leu Gln Glu Gly Asp Ile Val Asn Val Asp Ile Thr Leu Tyr 
    210                 215                 220                 


Arg Asn Gly Tyr His Gly Asp Leu Asn Glu Thr Phe Phe Val Gly Glu 
225                 230                 235                 240 


Val Asp Asp Gly Ala Arg Lys Leu Val Gln Thr Thr Tyr Glu Cys Leu 
                245                 250                 255     


Met Gln Ala Ile Asp Ala Val Lys Pro Gly Val Arg Tyr Arg Glu Leu 
            260                 265                 270         


Gly Asn Ile Ile Gln Lys His Ala Gln Ala Asn Gly Phe Ser Val Val 
        275                 280                 285             


Arg Ser Tyr Cys Gly His Gly Ile His Lys Leu Phe His Thr Ala Pro 
    290                 295                 300                 


Asn Val Pro His Tyr Ala Lys Asn Lys Ala Val Gly Val Met Lys Ser 
305                 310                 315                 320 


Gly His Val Phe Thr Ile Glu Pro Met Ile Cys Glu Gly Gly Trp Gln 
                325                 330                 335     


Asp Glu Thr Trp Pro Asp Gly Trp Thr Ala Val Thr Arg Asp Gly Lys 
            340                 345                 350         


Arg Ser Ala Gln Phe Glu His Thr Leu Leu Val Thr Asp Thr Gly Cys 
        355                 360                 365             


Glu Ile Leu Thr Arg Arg Leu Asp Ser Ala Arg Pro His Phe Met Ser 
    370                 375                 380                 


Gln Phe 
385     


<210>  1205
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  1205

Met Val Gln Lys Glu Ser Gln Ala Thr Leu Glu Glu Arg Glu Ser Glu 
1               5                   10                  15      


Leu Ser Ser Asn Pro Ala Ala Ser Ala Gly Ala Ser Leu Glu Pro Pro 
            20                  25                  30          


Ala Ala Pro Ala Pro Gly Glu Asp Asn Pro Ala Gly Ala Gly Gly Ala 
        35                  40                  45              


Ala Val Ala Gly Ala Ala Gly Gly Ala Arg Arg Phe Leu Cys Gly Val 
    50                  55                  60                  


Val Glu Gly Phe Tyr Gly Arg Pro Trp Val Met Glu Gln Arg Lys Glu 
65                  70                  75                  80  


Leu Phe Arg Arg Leu Gln Lys Trp Glu Leu Asn Thr Tyr Leu Tyr Ala 
                85                  90                  95      


Pro Lys Asp Asp Tyr Lys His Arg Met Phe Trp Arg Glu Met Tyr Ser 
            100                 105                 110         


Val Glu Glu Ala Glu Gln Leu Met Thr Leu Ile Ser Ala Ala Arg Glu 
        115                 120                 125             


Tyr Glu Ile Glu Phe Ile Tyr Ala Ile Ser Pro Gly Leu Asp Ile Thr 
    130                 135                 140                 


Phe Ser Asn Pro Lys Glu Val Ser Thr Leu Lys Arg Lys Leu Asp Gln 
145                 150                 155                 160 


Val Ser Gln Phe Gly Cys Arg Ser Phe Ala Leu Leu Phe Asp Asp Ile 
                165                 170                 175     


Asp His Asn Met Cys Ala Ala Asp Lys Glu Val Phe Ser Ser Phe Ala 
            180                 185                 190         


His Ala Gln Val Ser Ile Thr Asn Glu Ile Tyr Gln Tyr Leu Gly Glu 
        195                 200                 205             


Pro Glu Thr Phe Leu Phe Cys Pro Thr Glu Tyr Cys Gly Thr Phe Cys 
    210                 215                 220                 


Tyr Pro Asn Val Ser Gln Ser Pro Tyr Leu Arg Thr Val Gly Glu Lys 
225                 230                 235                 240 


Leu Leu Pro Gly Ile Glu Val Leu Trp Thr Gly Pro Lys Val Val Ser 
                245                 250                 255     


Lys Glu Ile Pro Val Glu Ser Ile Glu Glu Val Ser Lys Ile Ile Lys 
            260                 265                 270         


Arg Ala Pro Val Ile Trp Asp Asn Ile His Ala Asn Asp Tyr Asp Gln 
        275                 280                 285             


Lys Arg Leu Phe Leu Gly Pro Tyr Lys Gly Arg Ser Thr Glu Leu Ile 
    290                 295                 300                 


Pro Arg Leu Lys Gly Val Leu Thr Asn Pro Asn Cys Glu Phe Glu Ala 
305                 310                 315                 320 


Asn Tyr Val Ala Ile His Thr Leu Ala Thr Trp Tyr Lys Ser Asn Met 
                325                 330                 335     


Asn Gly Val Arg Lys Asp Val Val Met Thr Asp Ser Glu Asp Ser Thr 
            340                 345                 350         


Val Ser Ile Gln Ile Lys Leu Glu Asn Glu Gly Ser Asp Glu Asp Ile 
        355                 360                 365             


Glu Thr Asp Val Leu Tyr Ser Pro Gln Met Ala Leu Lys Leu Ala Leu 
    370                 375                 380                 


Thr Glu Trp Leu Gln Glu Phe Gly Val Pro His Gln Tyr Ser Ser Arg 
385                 390                 395                 400 


Gln Val Ala His Ser Gly Ala Lys Ala Ser Val Val Asp Gly Thr Pro 
                405                 410                 415     


Leu Val Ala Ala Pro Ser Leu Asn Ala Thr Thr Val Val Thr Thr Val 
            420                 425                 430         


Tyr Gln Glu Pro Ile Met Ser Gln Gly Ala Ala Leu Ser Gly Glu Pro 
        435                 440                 445             


Thr Thr Leu Thr Lys Glu Glu Glu Lys Lys Gln Pro Asp Glu Glu Pro 
    450                 455                 460                 


Met Asp Met Val Val Glu Lys Gln Glu Glu Thr Asp His Lys Asn Asp 
465                 470                 475                 480 


Asn Gln Ile Leu Ser Glu Ile Val Glu Ala Lys Met Ala Glu Glu Leu 
                485                 490                 495     


Lys Pro Met Asp Thr Asp Lys Glu Ser Ile Ala Glu Ser Lys Ser Pro 
            500                 505                 510         


Glu Met Ser Met Gln Glu Asp Cys Ile Ser Asp Ile Ala Pro Met Gln 
        515                 520                 525             


Thr Asp Glu Gln Thr Asn Lys Glu Gln Phe Val Pro Gly Pro Asn Glu 
    530                 535                 540                 


Lys Pro Leu Tyr Thr Ala Glu Pro Val Thr Leu Glu Asp Leu Gln Leu 
545                 550                 555                 560 


Leu Ala Asp Leu Phe Tyr Leu Pro Tyr Glu His Gly Pro Lys Gly Ala 
                565                 570                 575     


Gln Met Leu Arg Glu Phe Gln Trp Leu Arg Ala Asn Ser Ser Val Val 
            580                 585                 590         


Ser Val Asn Cys Lys Gly Lys Asp Ser Glu Lys Ile Glu Glu Trp Arg 
        595                 600                 605             


Ser Arg Ala Ala Lys Phe Glu Glu Met Cys Gly Leu Val Met Gly Met 
    610                 615                 620                 


Phe Thr Arg Leu Ser Asn Cys Ala Asn Arg Thr Ile Leu Tyr Asp Met 
625                 630                 635                 640 


Tyr Ser Tyr Val Trp Asp Ile Lys Ser Ile Met Ser Met Val Lys Ser 
                645                 650                 655     


Phe Val Gln Trp Leu Gly Cys Arg Ser His Ser Ser Ala Gln Phe Leu 
            660                 665                 670         


Ile Gly Asp Gln Glu Pro Trp Ala Phe Arg Gly Gly Leu Ala Gly Glu 
        675                 680                 685             


Phe Gln Arg Leu Leu Pro Ile Asp Gly Ala Asn Asp Leu Phe Phe Gln 
    690                 695                 700                 


Pro Pro Pro Leu Thr Pro Thr Ser Lys Val Tyr Thr Ile Arg Pro Tyr 
705                 710                 715                 720 


Phe Pro Lys Asp Glu Ala Ser Val Tyr Lys Ile Cys Arg Glu Met Tyr 
                725                 730                 735     


Asp Asp Gly Val Gly Leu Pro Phe Gln Ser Gln Pro Asp Leu Ile Gly 
            740                 745                 750         


Asp Lys Leu Val Gly Gly Leu Leu Ser Leu Ser Leu Asp Tyr Cys Phe 
        755                 760                 765             


Val Leu Glu Asp Glu Asp Gly Ile Cys Gly Tyr Ala Leu Gly Thr Val 
    770                 775                 780                 


Asp Val Thr Pro Phe Ile Lys Lys Cys Lys Ile Ser Trp Ile Pro Phe 
785                 790                 795                 800 


Met Gln Glu Lys Tyr Thr Lys Pro Asn Gly Asp Lys Glu Leu Ser Glu 
                805                 810                 815     


Ala Glu Lys Ile Met Leu Ser Phe His Glu Glu Gln Glu Val Leu Pro 
            820                 825                 830         


Glu Thr Phe Leu Ala Asn Phe Pro Ser Leu Ile Lys Met Asp Ile His 
        835                 840                 845             


Lys Lys Val Thr Asp Pro Ser Val Ala Lys Ser Met Met Ala Cys Leu 
    850                 855                 860                 


Leu Ser Ser Leu Lys Ala Asn Gly Ser Arg Gly Ala Phe Cys Glu Val 
865                 870                 875                 880 


Arg Pro Asp Asp Lys Arg Ile Leu Glu Phe Tyr Ser Lys Leu Gly Cys 
                885                 890                 895     


Phe Glu Ile Ala Lys Met Glu Gly Phe Pro Lys Asp Val Val Ile Leu 
            900                 905                 910         


Gly Arg Ser Leu 
        915     


<210>  1206
<211>  1027
<212>  PRT
<213>  Homo sapiens

<400>  1206

Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys 
                565                 570                 575     


Gln Glu Leu Lys Phe Ile Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
            580                 585                 590         


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
        595                 600                 605             


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
    610                 615                 620                 


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
625                 630                 635                 640 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
                645                 650                 655     


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
            660                 665                 670         


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
        675                 680                 685             


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
    690                 695                 700                 


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
705                 710                 715                 720 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
                725                 730                 735     


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
            740                 745                 750         


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
        755                 760                 765             


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
    770                 775                 780                 


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
785                 790                 795                 800 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
                805                 810                 815     


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
            820                 825                 830         


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
        835                 840                 845             


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
    850                 855                 860                 


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
865                 870                 875                 880 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
                885                 890                 895     


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
            900                 905                 910         


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
        915                 920                 925             


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
    930                 935                 940                 


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
945                 950                 955                 960 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
                965                 970                 975     


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
            980                 985                 990         


Leu Leu Asn Ser Gln Gln Leu Thr  Pro Val His Arg His  Pro His Phe 
        995                 1000                 1005             


Thr Gln  Leu Pro Pro Thr His  Phe Ser Pro Ser Met  Glu Ile Met 
    1010                 1015                 1020             


Gln Val  Arg Lys 
    1025         


<210>  1207
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  1207

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys 
        115                 120                 125             


Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val 
    130                 135                 140                 


Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile 
145                 150                 155                 160 


Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala 
                165                 170                 175     


Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile 
            180                 185                 190         


Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp 
        195                 200                 205             


Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Glu Leu 
    210                 215                 220                 


Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser Asp Asp Tyr 
225                 230                 235                 240 


Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala 
            260                 265                 270         


Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp 
        275                 280                 285             


Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys 
    290                 295                 300                 


Ala Leu Ser Leu Pro 
305                 


<210>  1208
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  1208

Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu 
1               5                   10                  15      


Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu 
            20                  25                  30          


Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Glu Leu Leu Leu Ser 
        35                  40                  45              


Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg 
    50                  55                  60                  


Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg 
65                  70                  75                  80  


Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu 
                85                  90                  95      


Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn 
            100                 105                 110         


Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu 
        115                 120                 125             


Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser 
    130                 135                 140                 


Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser 
145                 150                 155                 160 


Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile 
                165                 170                 175     


Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu 
            180                 185                 190         


Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys 
        195                 200                 205             


Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu 
    210                 215                 220                 


Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr 
225                 230                 235                 240 


Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser 
                245                 250                 255     


His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro 
            260                 265                 270         


Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly 
        275                 280                 285             


Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu 
    290                 295                 300                 


Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser 
305                 310                 315                 320 


Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile 
                325                 330                 335     


Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser 
            340                 345                 350         


Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His 
        355                 360                 365             


Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln 
    370                 375                 380                 


Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln 
385                 390                 395                 400 


Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val 
                405                 410                 415     


Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr 
            420                 425                 430         


Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys 
        435                 440                 445             


Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly 
    450                 455                 460         


<210>  1209
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  1209

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
145                 150                 155                 160 


Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                165                 170                 175     


Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
            180                 185                 190         


His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
    210                 215                 220                 


Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
225                 230                 235                 240 


Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                245                 250                 255     


Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
            260                 265                 270         


Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
        275                 280                 285             


Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
    290                 295                 300                 


Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
305                 310                 315         


<210>  1210
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  1210

Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr 
1               5                   10                  15      


His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gln Asn 
            20                  25                  30          


Ile Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu 
        35                  40                  45              


Ser Leu Gln Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu 
    50                  55                  60                  


Tyr Glu Arg Glu Ala Ile Leu Glu Tyr Ile Leu His Gln Lys Lys Glu 
65                  70                  75                  80  


Ile Ala Arg Gln Met Lys Ala Tyr Glu Lys Gln Arg Gly Thr Arg Arg 
                85                  90                  95      


Glu Glu Gln Lys Glu Leu Gln Arg Ala Ala Ser Gln Asp His Val Arg 
            100                 105                 110         


Gly Phe Leu Glu Lys Glu Ser Ala Ile Val Ser Arg Pro Leu Asn Pro 
        115                 120                 125             


Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gln Pro 
    130                 135                 140                 


Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 
145                 150                 155                 160 


Ser Phe Trp Ile Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu 
                165                 170                 175     


Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu 
            180                 185                 190         


Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser 
        195                 200                 205             


Val Asp Arg Val Gly Leu Ile Thr Arg Ser Glu Arg Tyr Val Cys Ala 
    210                 215                 220                 


Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu Ile Arg 
                245                 250                 255     


Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp 
            260                 265                 270         


Ile Ile Val Leu Gln Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val 
        275                 280                 285             


Lys Leu Gln Ala Glu Lys Ser Arg Pro Val Met Gln Ala 
    290                 295                 300     


<210>  1211
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  1211

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 


<210>  1212
<211>  1436
<212>  PRT
<213>  Homo sapiens

<400>  1212

Met Leu His Leu Ser Ala Ala Pro Pro Ala Pro Pro Pro Glu Val Thr 
1               5                   10                  15      


Ala Thr Ala Arg Pro Cys Leu Cys Ser Val Gly Arg Arg Gly Asp Gly 
            20                  25                  30          


Gly Lys Met Ala Ala Ala Gly Ala Leu Glu Arg Ser Phe Val Glu Leu 
        35                  40                  45              


Ser Gly Ala Glu Arg Glu Arg Pro Arg His Phe Arg Glu Phe Thr Val 
    50                  55                  60                  


Cys Ser Ile Gly Thr Ala Asn Ala Val Ala Gly Ala Val Lys Tyr Ser 
65                  70                  75                  80  


Glu Ser Ala Gly Gly Phe Tyr Tyr Val Glu Ser Gly Lys Leu Phe Ser 
                85                  90                  95      


Val Thr Arg Asn Arg Phe Ile His Trp Lys Thr Ser Gly Asp Thr Leu 
            100                 105                 110         


Glu Leu Met Glu Glu Ser Leu Asp Ile Asn Leu Leu Asn Asn Ala Ile 
        115                 120                 125             


Arg Leu Lys Phe Gln Asn Cys Ser Val Leu Pro Gly Gly Val Tyr Val 
    130                 135                 140                 


Ser Glu Thr Gln Asn Arg Val Ile Ile Leu Met Leu Thr Asn Gln Thr 
145                 150                 155                 160 


Val His Arg Leu Leu Leu Pro His Pro Ser Arg Met Tyr Arg Ser Glu 
                165                 170                 175     


Leu Val Val Asp Ser Gln Met Gln Ser Ile Phe Thr Asp Ile Gly Lys 
            180                 185                 190         


Val Asp Phe Thr Asp Pro Cys Asn Tyr Gln Leu Ile Pro Ala Val Pro 
        195                 200                 205             


Gly Ile Ser Pro Asn Ser Thr Ala Ser Thr Ala Trp Leu Ser Ser Asp 
    210                 215                 220                 


Gly Glu Ala Leu Phe Ala Leu Pro Cys Ala Ser Gly Gly Ile Phe Val 
225                 230                 235                 240 


Leu Lys Leu Pro Pro Tyr Asp Ile Pro Gly Met Val Ser Val Val Glu 
                245                 250                 255     


Leu Lys Gln Ser Ser Val Met Gln Arg Leu Leu Thr Gly Trp Met Pro 
            260                 265                 270         


Thr Ala Ile Arg Gly Asp Gln Ser Pro Ser Asp Arg Pro Leu Ser Leu 
        275                 280                 285             


Ala Val His Cys Val Glu His Asp Ala Phe Ile Phe Ala Leu Cys Gln 
    290                 295                 300                 


Asp His Lys Leu Arg Met Trp Ser Tyr Lys Glu Gln Met Cys Leu Met 
305                 310                 315                 320 


Val Ala Asp Met Leu Glu Tyr Val Pro Val Lys Lys Asp Leu Arg Leu 
                325                 330                 335     


Thr Ala Gly Thr Gly His Lys Leu Arg Leu Ala Tyr Ser Pro Thr Met 
            340                 345                 350         


Gly Leu Tyr Leu Gly Ile Tyr Met His Ala Pro Lys Arg Gly Gln Phe 
        355                 360                 365             


Cys Ile Phe Gln Leu Val Ser Thr Glu Ser Asn Arg Tyr Ser Leu Asp 
    370                 375                 380                 


His Ile Ser Ser Leu Phe Thr Ser Gln Glu Thr Leu Ile Asp Phe Ala 
385                 390                 395                 400 


Leu Thr Ser Thr Asp Ile Trp Ala Leu Trp His Asp Ala Glu Asn Gln 
                405                 410                 415     


Thr Val Val Lys Tyr Ile Asn Phe Glu His Asn Val Ala Gly Gln Trp 
            420                 425                 430         


Asn Pro Val Phe Met Gln Pro Leu Pro Glu Glu Glu Ile Val Ile Arg 
        435                 440                 445             


Asp Asp Gln Asp Pro Arg Glu Met Tyr Leu Gln Ser Leu Phe Thr Pro 
    450                 455                 460                 


Gly Gln Phe Thr Asn Glu Ala Leu Cys Lys Ala Leu Gln Ile Phe Cys 
465                 470                 475                 480 


Arg Gly Thr Glu Arg Asn Leu Asp Leu Ser Trp Ser Glu Leu Lys Lys 
                485                 490                 495     


Glu Val Thr Leu Ala Val Glu Asn Glu Leu Gln Gly Ser Val Thr Glu 
            500                 505                 510         


Tyr Glu Phe Ser Gln Glu Glu Phe Arg Asn Leu Gln Gln Glu Phe Trp 
        515                 520                 525             


Cys Lys Phe Tyr Ala Cys Cys Leu Gln Tyr Gln Glu Ala Leu Ser His 
    530                 535                 540                 


Pro Leu Ala Leu His Leu Asn Pro His Thr Asn Met Val Cys Leu Leu 
545                 550                 555                 560 


Lys Lys Gly Tyr Leu Ser Phe Leu Ile Pro Ser Ser Leu Val Asp His 
                565                 570                 575     


Leu Tyr Leu Leu Pro Tyr Glu Asn Leu Leu Thr Glu Asp Glu Thr Thr 
            580                 585                 590         


Ile Ser Asp Asp Val Asp Ile Ala Arg Asp Val Ile Cys Leu Ile Lys 
        595                 600                 605             


Cys Leu Arg Leu Ile Glu Glu Ser Val Thr Val Asp Met Ser Val Ile 
    610                 615                 620                 


Met Glu Met Ser Cys Tyr Asn Leu Gln Ser Pro Glu Lys Ala Ala Glu 
625                 630                 635                 640 


Gln Ile Leu Glu Asp Met Ile Thr Ile Asp Val Glu Asn Val Met Glu 
                645                 650                 655     


Asp Ile Cys Ser Lys Leu Gln Glu Ile Arg Asn Pro Ile His Ala Ile 
            660                 665                 670         


Gly Leu Leu Ile Arg Glu Met Asp Tyr Glu Thr Glu Val Glu Met Glu 
        675                 680                 685             


Lys Gly Phe Asn Pro Ala Gln Pro Leu Asn Ile Arg Met Asn Leu Thr 
    690                 695                 700                 


Gln Leu Tyr Gly Ser Asn Thr Ala Gly Tyr Ile Val Cys Arg Gly Val 
705                 710                 715                 720 


His Lys Ile Ala Ser Thr Arg Phe Leu Ile Cys Arg Asp Leu Leu Ile 
                725                 730                 735     


Leu Gln Gln Leu Leu Met Arg Leu Gly Asp Ala Val Ile Trp Gly Thr 
            740                 745                 750         


Gly Gln Leu Phe Gln Ala Gln Gln Asp Leu Leu His Arg Thr Ala Pro 
        755                 760                 765             


Leu Leu Leu Ser Tyr Tyr Leu Ile Lys Trp Gly Ser Glu Cys Leu Ala 
    770                 775                 780                 


Thr Asp Val Pro Leu Asp Thr Leu Glu Ser Asn Leu Gln His Leu Ser 
785                 790                 795                 800 


Val Leu Glu Leu Thr Asp Ser Gly Ala Leu Met Ala Asn Arg Phe Val 
                805                 810                 815     


Ser Ser Pro Gln Thr Ile Val Glu Leu Phe Phe Gln Glu Val Ala Arg 
            820                 825                 830         


Lys His Ile Ile Ser His Leu Phe Ser Gln Pro Lys Ala Pro Leu Ser 
        835                 840                 845             


Gln Thr Gly Leu Asn Trp Pro Glu Met Ile Thr Ala Ile Thr Ser Tyr 
    850                 855                 860                 


Leu Leu Gln Leu Leu Trp Pro Ser Asn Pro Gly Cys Leu Phe Leu Glu 
865                 870                 875                 880 


Cys Leu Met Gly Asn Cys Gln Tyr Val Gln Leu Gln Asp Tyr Ile Gln 
                885                 890                 895     


Leu Leu His Pro Trp Cys Gln Val Asn Val Gly Ser Cys Arg Phe Met 
            900                 905                 910         


Leu Gly Arg Cys Tyr Leu Val Thr Gly Glu Gly Gln Lys Ala Leu Glu 
        915                 920                 925             


Cys Phe Cys Gln Ala Ala Ser Glu Val Gly Lys Glu Glu Phe Leu Asp 
    930                 935                 940                 


Arg Leu Ile Arg Ser Glu Asp Gly Glu Ile Val Ser Thr Pro Arg Leu 
945                 950                 955                 960 


Gln Tyr Tyr Asp Lys Val Leu Arg Leu Leu Asp Val Ile Gly Leu Pro 
                965                 970                 975     


Glu Leu Val Ile Gln Leu Ala Thr Ser Ala Ile Thr Glu Ala Gly Asp 
            980                 985                 990         


Asp Trp Lys Ser Gln Ala Thr Leu  Arg Thr Cys Ile Phe  Lys His His 
        995                 1000                 1005             


Leu Asp  Leu Gly His Asn Ser  Gln Ala Tyr Glu Ala  Leu Thr Gln 
    1010                 1015                 1020             


Ile Pro  Asp Ser Ser Arg Gln  Leu Asp Cys Leu Arg  Gln Leu Val 
    1025                 1030                 1035             


Val Val  Leu Cys Glu Arg Ser  Gln Leu Gln Asp Leu  Val Glu Phe 
    1040                 1045                 1050             


Pro Tyr  Val Asn Leu His Asn  Glu Val Val Gly Ile  Ile Glu Ser 
    1055                 1060                 1065             


Arg Ala  Arg Ala Val Asp Leu  Met Thr His Asn Tyr  Tyr Glu Leu 
    1070                 1075                 1080             


Leu Tyr  Ala Phe His Ile Tyr  Arg His Asn Tyr Arg  Lys Ala Gly 
    1085                 1090                 1095             


Thr Val  Met Phe Glu Tyr Gly  Met Arg Leu Gly Arg  Glu Val Arg 
    1100                 1105                 1110             


Thr Leu  Arg Gly Leu Glu Lys  Gln Gly Asn Cys Tyr  Leu Ala Ala 
    1115                 1120                 1125             


Leu Asn  Cys Leu Arg Leu Ile  Arg Pro Glu Tyr Ala  Trp Ile Val 
    1130                 1135                 1140             


Gln Pro  Val Ser Gly Ala Val  Tyr Asp Arg Pro Gly  Ala Ser Pro 
    1145                 1150                 1155             


Lys Arg  Asn His Asp Gly Glu  Cys Thr Ala Ala Pro  Thr Asn Arg 
    1160                 1165                 1170             


Gln Ile  Glu Ile Leu Glu Leu  Glu Asp Leu Glu Lys  Glu Cys Ser 
    1175                 1180                 1185             


Leu Ala  Arg Ile Arg Leu Thr  Leu Ala Gln His Asp  Pro Ser Ala 
    1190                 1195                 1200             


Val Ala  Val Ala Gly Ser Ser  Ser Ala Glu Glu Met  Val Thr Leu 
    1205                 1210                 1215             


Leu Val  Gln Ala Gly Leu Phe  Asp Thr Ala Ile Ser  Leu Cys Gln 
    1220                 1225                 1230             


Thr Phe  Lys Leu Pro Leu Thr  Pro Val Phe Glu Gly  Leu Ala Phe 
    1235                 1240                 1245             


Lys Cys  Ile Lys Leu Gln Phe  Gly Gly Glu Ala Ala  Gln Ala Glu 
    1250                 1255                 1260             


Ala Trp  Ala Trp Leu Ala Ala  Asn Gln Leu Ser Ser  Val Ile Thr 
    1265                 1270                 1275             


Thr Lys  Glu Ser Ser Ala Thr  Asp Glu Ala Trp Arg  Leu Leu Ser 
    1280                 1285                 1290             


Thr Tyr  Leu Glu Arg Tyr Lys  Val Gln Asn Asn Leu  Tyr His His 
    1295                 1300                 1305             


Cys Val  Ile Asn Lys Leu Leu  Ser His Gly Val Pro  Leu Pro Asn 
    1310                 1315                 1320             


Trp Leu  Ile Asn Ser Tyr Lys  Lys Val Asp Ala Ala  Glu Leu Leu 
    1325                 1330                 1335             


Arg Leu  Tyr Leu Asn Tyr Asp  Leu Leu Glu Glu Ala  Val Asp Leu 
    1340                 1345                 1350             


Val Ser  Glu Tyr Val Asp Ala  Val Leu Gly Lys Gly  His Gln Tyr 
    1355                 1360                 1365             


Phe Gly  Ile Glu Phe Pro Leu  Ser Ala Thr Ala Pro  Met Val Trp 
    1370                 1375                 1380             


Leu Pro  Tyr Ser Ser Ile Asp  Gln Leu Leu Gln Ala  Leu Gly Glu 
    1385                 1390                 1395             


Asn Ser  Ala Asn Ser His Asn  Ile Ala Leu Ser Gln  Lys Ile Leu 
    1400                 1405                 1410             


Asp Lys  Leu Glu Asp Tyr Gln  Gln Lys Val Asp Lys  Ala Thr Arg 
    1415                 1420                 1425             


Asp Leu  Leu Tyr Arg Arg Thr  Leu 
    1430                 1435     


<210>  1213
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  1213

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Ser Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  1214
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1214

Met Ala His Ile Thr Ile Asn Gln Tyr Leu Gln Gln Val Tyr Glu Ala 
1               5                   10                  15      


Ile Asp Ser Arg Asp Gly Ala Ser Cys Ala Glu Leu Val Ser Phe Lys 
            20                  25                  30          


His Pro His Val Ala Asn Pro Arg Leu Gln Met Ala Ser Pro Glu Glu 
        35                  40                  45              


Lys Cys Gln Gln Val Leu Glu Pro Pro Tyr Asp Glu Met Phe Ala Ala 
    50                  55                  60                  


His Leu Arg Cys Thr Tyr Ala Val Gly Asn His Asp Phe Ile Glu Ala 
65                  70                  75                  80  


Tyr Lys Cys Gln Thr Val Ile Val Gln Ser Phe Leu Arg Ala Phe Gln 
                85                  90                  95      


Ala His Lys Glu Glu Asn Trp Ala Leu Pro Val Met Tyr Ala Val Ala 
            100                 105                 110         


Leu Asp Leu Arg Val Phe Ala Asn Asn Ala Asp Gln Gln Leu Val Lys 
        115                 120                 125             


Lys Gly Lys Ser Lys Val Gly Asp Met Leu Glu Lys Ala Ala Glu Leu 
    130                 135                 140                 


Leu Met Ser Cys Phe Arg Val Cys Ala Ser Asp Thr Arg Ala Gly Ile 
145                 150                 155                 160 


Glu Asp Ser Lys Lys Trp Gly Met Leu Phe Leu Val Asn Gln Leu Phe 
                165                 170                 175     


Lys Ile Tyr Phe Lys Ile Asn Lys Leu His Leu Cys Lys Pro Leu Ile 
            180                 185                 190         


Arg Ala Ile Asp Ser Ser Asn Leu Lys Asp Asp Tyr Ser Thr Ala Gln 
        195                 200                 205             


Arg Val Thr Tyr Lys Tyr Tyr Val Gly Arg Lys Ala Met Phe Asp Ser 
    210                 215                 220                 


Asp Phe Lys Gln Ala Glu Glu Tyr Leu Ser Phe Ala Phe Glu His Cys 
225                 230                 235                 240 


His Arg Ser Ser Gln Lys Asn Lys Arg Met Ile Leu Ile Tyr Leu Leu 
                245                 250                 255     


Pro Val Lys Met Leu Leu Gly His Met Pro Thr Val Glu Leu Leu Lys 
            260                 265                 270         


Lys Tyr His Leu Met Gln Phe Ala Glu Val Thr Arg Ala Val Ser Glu 
        275                 280                 285             


Gly Asn Leu Leu Leu Leu His Glu Ala Leu Ala Lys His Glu Ala Phe 
    290                 295                 300                 


Phe Ile Arg Cys Gly Ile Phe Leu Ile Leu Glu Lys Leu Lys Ile Ile 
305                 310                 315                 320 


Thr Tyr Arg Asn Leu Phe Lys Lys Val Tyr Leu Leu Leu Lys Thr His 
                325                 330                 335     


Gln Leu Ser Leu Asp Ala Phe Leu Val Ala Leu Lys Phe Met Gln Val 
            340                 345                 350         


Glu Asp Val Asp Ile Asp Glu Val Gln Cys Ile Leu Ala Asn Leu Ile 
        355                 360                 365             


Tyr Met Gly His Val Lys Gly Tyr Ile Ser His Gln His Gln Lys Leu 
    370                 375                 380                 


Val Val Ser Lys Gln Asn Pro Phe Pro Pro Leu Ser Thr Val Cys 
385                 390                 395                 


<210>  1215
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1215

Met Pro Gly Ala Arg Ser Gly Gly Ser Gly Gly Asp Gly Ser Asn Ser 
1               5                   10                  15      


Gly Ser Tyr Ser Gly Asp Ala Ser Gly Ala Val Thr Val Trp Glu Val 
            20                  25                  30          


Val Ser Leu Leu Gly Lys Leu Leu Gly Thr Val Val Ala Leu Lys Val 
        35                  40                  45              


Val Leu Tyr Leu Leu Arg Val Cys Leu Ala Met Ala Trp Lys Ser Gly 
    50                  55                  60                  


Gly Ala Ser His Ser Glu Leu Ile His Asn Leu Arg Lys Asn Gly Ile 
65                  70                  75                  80  


Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu Ala Thr Asp Arg Ser 
                85                  90                  95      


His Tyr Ala Lys Cys Asn Pro Tyr Met Asp Ser Pro Gln Ser Ile Gly 
            100                 105                 110         


Phe Gln Ala Thr Ile Ser Ala Pro His Met His Ala Tyr Ala Leu Glu 
        115                 120                 125             


Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys Ala Leu Asp Val Gly 
    130                 135                 140                 


Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala Arg Met Val Gly Cys 
145                 150                 155                 160 


Thr Gly Lys Val Ile Gly Ile Asp His Ile Lys Glu Leu Val Asp Asp 
                165                 170                 175     


Ser Val Asn Asn Val Arg Lys Asp Asp Pro Thr Leu Leu Ser Ser Gly 
            180                 185                 190         


Arg Val Gln Leu Val Val Gly Asp Gly Arg Met Gly Tyr Ala Glu Glu 
        195                 200                 205             


Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala Ala Pro Val Val Pro 
    210                 215                 220                 


Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly Arg Leu Ile Leu Pro 
225                 230                 235                 240 


Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu Gln Tyr Asp Lys Leu 
                245                 250                 255     


Gln Asp Gly Ser Ile Lys Met Lys Pro Leu Met Gly Val Ile Tyr Val 
            260                 265                 270         


Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg Trp Lys 
        275                 280                 285 


<210>  1216
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  1216

Met Ala Gln Ala Asp Ile Ala Leu Ile Gly Leu Ala Val Met Gly Gln 
1               5                   10                  15      


Asn Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val Cys Ala Phe 
            20                  25                  30          


Asn Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn Glu Ala Lys 
        35                  40                  45              


Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala 
65                  70                  75                  80  


Val Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp Thr Gly Asp 
                85                  90                  95      


Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg 
            100                 105                 110         


Cys Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val 
        115                 120                 125             


Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly 
    130                 135                 140                 


Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Ile 
145                 150                 155                 160 


Ala Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp Val Gly Asp 
                165                 170                 175     


Glu Gly Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         


Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val 
        195                 200                 205             


Leu Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu Asp Trp Asn 
    210                 215                 220                 


Lys Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu 
225                 230                 235                 240 


Lys Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp 
                245                 250                 255     


Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Ser Ala Leu 
            260                 265                 270         


Glu Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg 
        275                 280                 285             


Cys Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser Lys Lys Leu 
    290                 295                 300                 


Lys Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu 
305                 310                 315                 320 


Glu Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala 
                325                 330                 335     


Gln Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe Gly Trp Thr 
            340                 345                 350         


Leu Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile 
        355                 360                 365             


Arg Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro 
    370                 375                 380                 


Glu Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser Ala Val Glu 
385                 390                 395                 400 


Asn Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly Val Gln Ala 
                405                 410                 415     


Gly Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe Tyr Asp Gly 
            420                 425                 430         


Tyr Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala Gln Arg Asp 
        435                 440                 445             


Tyr Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe 
    450                 455                 460                 


Ile His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser Ser Ser Ser 
465                 470                 475                 480 


Tyr Asn Ala 
            


<210>  1217
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  1217

Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys 
1               5                   10                  15      


Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly 
            20                  25                  30          


Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr 
        35                  40                  45              


Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu 
    50                  55                  60                  


Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg 
65                  70                  75                  80  


Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp 
                85                  90                  95      


Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser 
            100                 105                 110         


Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu 
        115                 120                 125             


Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys 
    130                 135                 140                 


Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro 
145                 150                 155                 160 


Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro 
                165                 170                 175     


Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys 
            180                 185                 190         


Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn 
        195                 200                 205             


Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr 
    210                 215                 220                 


His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro 
225                 230                 235                 240 


Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln 
                245                 250                 255     


Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala 
            260                 265                 270         


His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys 
        275                 280                 285             


Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser 
    290                 295                 300                 


Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr 
305                 310                 315                 320 


Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr 
                325                 330                 335 


<210>  1218
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  1218

Met Asp Lys Gln Asn Ser Gln Met Asn Ala Ser His Pro Glu Thr Asn 
1               5                   10                  15      


Leu Pro Val Gly Tyr Pro Pro Gln Tyr Pro Pro Thr Ala Phe Gln Gly 
            20                  25                  30          


Pro Pro Gly Tyr Ser Gly Tyr Pro Gly Pro Gln Val Ser Tyr Pro Pro 
        35                  40                  45              


Pro Pro Ala Gly His Ser Gly Pro Gly Pro Ala Gly Phe Pro Val Pro 
    50                  55                  60                  


Asn Gln Pro Val Tyr Asn Gln Pro Val Tyr Asn Gln Pro Val Gly Ala 
65                  70                  75                  80  


Ala Gly Val Pro Trp Met Pro Ala Pro Gln Pro Pro Leu Asn Cys Pro 
                85                  90                  95      


Pro Gly Leu Glu Tyr Leu Ser Gln Ile Asp Gln Ile Leu Ile His Gln 
            100                 105                 110         


Gln Ile Glu Leu Leu Glu Val Leu Thr Gly Phe Glu Thr Asn Asn Lys 
        115                 120                 125             


Tyr Glu Ile Lys Asn Ser Phe Gly Gln Arg Val Tyr Phe Ala Ala Glu 
    130                 135                 140                 


Asp Thr Asp Cys Cys Thr Arg Asn Cys Cys Gly Pro Ser Arg Pro Phe 
145                 150                 155                 160 


Thr Leu Arg Ile Ile Asp Asn Met Gly Gln Glu Val Ile Thr Leu Glu 
                165                 170                 175     


Arg Pro Leu Arg Cys Ser Ser Cys Cys Cys Pro Cys Cys Leu Gln Glu 
            180                 185                 190         


Ile Glu Ile Gln Ala Pro Pro Gly Val Pro Ile Gly Tyr Val Ile Gln 
        195                 200                 205             


Thr Trp His Pro Cys Leu Pro Lys Phe Thr Ile Gln Asn Glu Lys Arg 
    210                 215                 220                 


Glu Asp Val Leu Lys Ile Ser Gly Pro Cys Val Val Cys Ser Cys Cys 
225                 230                 235                 240 


Gly Asp Val Asp Phe Glu Ile Lys Ser Leu Asp Glu Gln Cys Val Val 
                245                 250                 255     


Gly Lys Ile Ser Lys His Trp Thr Gly Ile Leu Arg Glu Ala Phe Thr 
            260                 265                 270         


Asp Ala Asp Asn Phe Gly Ile Gln Phe Pro Leu Asp Leu Asp Val Lys 
        275                 280                 285             


Met Lys Ala Val Met Ile Gly Ala Cys Phe Leu Ile Asp Phe Met Phe 
    290                 295                 300                 


Phe Glu Ser Thr Gly Ser Gln Glu Gln Lys Ser Gly Val Trp 
305                 310                 315             


<210>  1219
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1219

Met Asn Ala Arg Gly Leu Gly Ser Glu Leu Lys Asp Ser Ile Pro Val 
1               5                   10                  15      


Thr Glu Leu Ser Ala Ser Gly Pro Phe Glu Ser His Asp Leu Leu Arg 
            20                  25                  30          


Lys Gly Phe Ser Cys Val Lys Asn Glu Leu Leu Pro Ser His Pro Leu 
        35                  40                  45              


Glu Leu Ser Glu Lys Asn Phe Gln Leu Asn Gln Asp Lys Met Asn Phe 
    50                  55                  60                  


Ser Thr Leu Arg Asn Ile Gln Gly Leu Phe Ala Pro Leu Lys Leu Gln 
65                  70                  75                  80  


Met Glu Phe Lys Ala Val Gln Gln Val Gln Arg Leu Pro Phe Leu Ser 
                85                  90                  95      


Ser Ser Asn Leu Ser Leu Asp Val Leu Arg Gly Asn Asp Glu Thr Ile 
            100                 105                 110         


Gly Phe Glu Asp Ile Leu Asn Asp Pro Ser Gln Ser Glu Val Met Gly 
        115                 120                 125             


Glu Pro His Leu Met Val Glu Tyr Lys Leu Gly Leu Leu 
    130                 135                 140     


<210>  1220
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  1220

Met Gln Gln Lys Thr Lys Leu Phe Leu Gln Ala Leu Lys Tyr Ser Ile 
1               5                   10                  15      


Pro His Leu Gly Lys Cys Met Gln Lys Gln His Leu Asn His Tyr Asn 
            20                  25                  30          


Phe Ala Asp His Cys Tyr Asn Arg Ile Lys Leu Lys Lys Tyr His Leu 
        35                  40                  45              


Thr Lys Cys Leu Gln Asn Lys Pro Lys Ile Ser Glu Leu Ala Arg Asn 
    50                  55                  60                  


Ile Pro Ser Arg Ser Phe Ser Cys Lys Asp Leu Gln Pro Val Lys Gln 
65                  70                  75                  80  


Glu Asn Glu Lys Pro Leu Pro Glu Asn Met Asp Ala Phe Glu Lys Val 
                85                  90                  95      


Arg Thr Lys Leu Glu Thr Gln Pro Gln Glu Glu Tyr Glu Ile Ile Asn 
            100                 105                 110         


Val Glu Val Lys His Gly Gly Phe Val Tyr Tyr Gln Glu Gly Cys Cys 
        115                 120                 125             


Leu Val Arg Ser Lys Asp Glu Glu Ala Asp Asn Asp Asn Tyr Glu Val 
    130                 135                 140                 


Leu Phe Asn Leu Glu Glu Leu Lys Leu Asp Gln Pro Phe Ile Asp Cys 
145                 150                 155                 160 


Ile Arg Val Ala Pro Asp Glu Lys Tyr Val Ala Ala Lys Ile Arg Thr 
                165                 170                 175     


Glu Asp Ser Glu Ala Ser Thr Cys Val Ile Ile Lys Leu Ser Asp Gln 
            180                 185                 190         


Pro Val Met Glu Ala Ser Phe Pro Asn Val Ser Ser Phe Glu Trp Val 
        195                 200                 205             


Lys Asp Glu Glu Asp Glu Asp Val Leu Phe Tyr Thr Phe Gln Arg Asn 
    210                 215                 220                 


Leu Arg Cys His Asp Val Tyr Arg Ala Thr Phe Gly Asp Asn Lys Arg 
225                 230                 235                 240 


Asn Glu Arg Phe Tyr Thr Glu Lys Asp Pro Ser Tyr Phe Val Phe Leu 
                245                 250                 255     


Tyr Leu Thr Lys Asp Ser Arg Phe Leu Thr Ile Asn Ile Met Asn Lys 
            260                 265                 270         


Thr Thr Ser Glu Val Trp Leu Ile Asp Gly Leu Ser Pro Trp Asp Pro 
        275                 280                 285             


Pro Val Leu Ile Gln Lys Arg Ile His Gly Val Leu Tyr Tyr Val Glu 
    290                 295                 300                 


His Arg Asp Asp Glu Leu Tyr Ile Leu Thr Asn Val Gly Glu Pro Thr 
305                 310                 315                 320 


Glu Phe Lys Leu Met Arg Thr Ala Ala Asp Thr Pro Ala Ile Met Asn 
                325                 330                 335     


Trp Asp Leu Phe Phe Thr Met Lys Arg Asn Thr Lys Val Ile Asp Leu 
            340                 345                 350         


Asp Met Phe Lys Asp His Cys Val Leu Phe Leu Lys His Ser Asn Leu 
        355                 360                 365             


Leu Tyr Val Asn Val Ile Gly Leu Ala Asp Asp Ser Val Arg Ser Leu 
    370                 375                 380                 


Lys Leu Pro Pro Trp Ala Cys Gly Phe Ile Met Asp Thr Asn Ser Asp 
385                 390                 395                 400 


Pro Lys Asn Cys Pro Phe Gln Leu Cys Ser Pro Ile Arg Pro Pro Lys 
                405                 410                 415     


Tyr Tyr Thr Tyr Lys Phe Ala Glu Gly Lys Leu Phe Glu Glu Thr Gly 
            420                 425                 430         


His Glu Asp Pro Ile Thr Lys Thr Ser Arg Val Leu Arg Leu Glu Ala 
        435                 440                 445             


Lys Ser Lys Asp Gly Lys Leu Val Pro Met Thr Val Phe His Lys Thr 
    450                 455                 460                 


Asp Ser Glu Asp Leu Gln Lys Lys Pro Leu Leu Val His Val Tyr Gly 
465                 470                 475                 480 


Ala Tyr Gly Met Asp Leu Lys Met Asn Phe Arg Pro Glu Arg Arg Val 
                485                 490                 495     


Leu Val Asp Asp Gly Trp Ile Leu Ala Tyr Cys His Val Arg Gly Gly 
            500                 505                 510         


Gly Glu Leu Gly Leu Gln Trp His Ala Asp Gly Arg Leu Thr Lys Lys 
        515                 520                 525             


Leu Asn Gly Leu Ala Asp Leu Glu Ala Cys Ile Lys Thr Leu His Gly 
    530                 535                 540                 


Gln Gly Phe Ser Gln Pro Ser Leu Thr Thr Leu Thr Ala Phe Ser Ala 
545                 550                 555                 560 


Gly Gly Val Leu Ala Gly Ala Leu Cys Asn Ser Asn Pro Glu Leu Val 
                565                 570                 575     


Arg Ala Val Thr Leu Glu Ala Pro Phe Leu Asp Val Leu Asn Thr Met 
            580                 585                 590         


Met Asp Thr Thr Leu Pro Leu Thr Leu Glu Glu Leu Glu Glu Trp Gly 
        595                 600                 605             


Asn Pro Ser Ser Asp Glu Lys His Lys Asn Tyr Ile Lys Arg Tyr Cys 
    610                 615                 620                 


Pro Tyr Gln Asn Ile Lys Pro Gln His Tyr Pro Ser Ile His Ile Thr 
625                 630                 635                 640 


Ala Tyr Glu Asn Asp Glu Arg Val Pro Leu Lys Gly Ile Val Ser Tyr 
                645                 650                 655     


Thr Glu Lys Leu Lys Glu Ala Ile Ala Glu His Ala Lys Asp Thr Gly 
            660                 665                 670         


Glu Gly Tyr Gln Thr Pro Asn Ile Ile Leu Asp Ile Gln Pro Gly Gly 
        675                 680                 685             


Asn His Val Ile Glu Asp Ser His Lys Lys Ile Thr Ala Gln Ile Lys 
    690                 695                 700                 


Phe Leu Tyr Glu Glu Leu Gly Leu Asp Ser Thr Ser Val Phe Glu Asp 
705                 710                 715                 720 


Leu Lys Lys Tyr Leu Lys Phe 
                725         


<210>  1221
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  1221

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  1222
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  1222

Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210>  1223
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1223

Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
            20                  25                  30          


Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
        35                  40                  45              


Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
65                  70                  75                  80  


Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                85                  90                  95      


Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
            100                 105                 110         


Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
        115                 120                 125             


Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
    130                 135                 140                 


Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
145                 150                 155                 160 


Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                165                 170                 175     


Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
            180                 185                 190         


Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
        195                 200                 205         


<210>  1224
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  1224

Met Ala Ala Asn Lys Ser Lys Gly Gln Ser Ser Leu Ala Leu His Lys 
1               5                   10                  15      


Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
            20                  25                  30          


Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
        35                  40                  45              


Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
65                  70                  75                  80  


Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                85                  90                  95      


Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
        115                 120                 125             


Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
    130                 135                 140                 


Ser Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
145                 150                 155                 160 


Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                165                 170                 175     


Arg Thr Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Lys Lys Ser 
            180                 185                 190         


Ser Lys Asn Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
        195                 200                 205     


<210>  1225
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  1225

Met Gly Lys Val Trp Lys Gln Gln Met Tyr Pro Gln Tyr Ala Thr Tyr 
1               5                   10                  15      


Tyr Tyr Pro Gln Tyr Leu Gln Ala Lys Gln Ser Leu Val Pro Ala His 
            20                  25                  30          


Pro Met Ala Pro Pro Ser Pro Ser Thr Thr Ser Ser Asn Asn Asn Ser 
        35                  40                  45              


Ser Ser Ser Ser Asn Ser Gly Trp Asp Gln Leu Ser Lys Thr Asn Leu 
    50                  55                  60                  


Tyr Ile Arg Gly Leu Pro Pro His Thr Thr Asp Gln Asp Leu Val Lys 
65                  70                  75                  80  


Leu Cys Gln Pro Tyr Gly Lys Ile Val Ser Thr Lys Ala Ile Leu Asp 
                85                  90                  95      


Lys Thr Thr Asn Lys Cys Lys Gly Tyr Gly Phe Val Asp Phe Asp Ser 
            100                 105                 110         


Pro Ala Ala Ala Gln Lys Ala Val Ser Ala Leu Lys Ala Ser Gly Val 
        115                 120                 125             


Gln Ala Gln Met Ala Lys Gln Gln Glu Gln Asp Pro Thr Asn Leu Tyr 
    130                 135                 140                 


Ile Ser Asn Leu Pro Leu Ser Met Asp Glu Gln Glu Leu Glu Asn Met 
145                 150                 155                 160 


Leu Lys Pro Phe Gly Gln Val Ile Ser Thr Arg Ile Leu Arg Asp Ser 
                165                 170                 175     


Ser Gly Thr Ser Arg Gly Val Gly Phe Ala Arg Met Glu Ser Thr Glu 
            180                 185                 190         


Lys Cys Glu Ala Val Ile Gly His Phe Asn Gly Lys Phe Ile Lys Thr 
        195                 200                 205             


Pro Pro Gly Val Ser Ala Pro Thr Glu Pro Leu Leu Cys Lys Phe Ala 
    210                 215                 220                 


Asp Gly Gly Gln Lys Lys Arg Gln Asn Pro Asn Lys Tyr Ile Pro Asn 
225                 230                 235                 240 


Gly Arg Pro Trp His Arg Glu Gly Glu Val Arg Leu Ala Gly Met Thr 
                245                 250                 255     


Leu Thr Tyr Asp Pro Thr Thr Ala Ala Ile Gln Asn Gly Phe Tyr Pro 
            260                 265                 270         


Ser Pro Tyr Ser Ile Ala Thr Asn Arg Met Ile Thr Gln Thr Ser Ile 
        275                 280                 285             


Thr Pro Tyr Ile Ala Ser Pro Val Ser Ala Tyr Gln Val Gln Ser Pro 
    290                 295                 300                 


Ser Trp Met Gln Pro Gln Pro Tyr Ile Leu Gln His Pro Gly Ala Val 
305                 310                 315                 320 


Leu Thr Pro Ser Met Glu His Thr Met Ser Leu Gln Pro Ala Ser Met 
                325                 330                 335     


Ile Ser Pro Leu Ala Gln Gln Met Ser His Leu Ser Leu Gly Ser Thr 
            340                 345                 350         


Gly Thr Tyr Met Pro Ala Thr Ser Ala Met Gln Gly Ala Tyr Leu Pro 
        355                 360                 365             


Gln Tyr Ala His Met Gln Thr Thr Ala Val Pro Val Glu Glu Ala Ser 
    370                 375                 380                 


Gly Gln Gln Gln Val Ala Val Glu Thr Ser Asn Asp His Ser Pro Tyr 
385                 390                 395                 400 


Thr Phe Gln Pro Asn Lys 
                405     


<210>  1226
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  1226

Met Asp Ser Gly Thr Arg Pro Val Gly Ser Cys Cys Ser Ser Pro Ala 
1               5                   10                  15      


Gly Leu Ser Arg Glu Tyr Lys Leu Val Met Leu Gly Ala Gly Gly Val 
            20                  25                  30          


Gly Lys Ser Ala Met Thr Met Gln Phe Ile Ser His Arg Phe Pro Glu 
        35                  40                  45              


Asp His Asp Pro Thr Ile Glu Asp Ala Tyr Lys Ile Arg Ile Arg Ile 
    50                  55                  60                  


Asp Asp Glu Pro Ala Asn Leu Asp Ile Leu Asp Thr Ala Gly Gln Ala 
65                  70                  75                  80  


Glu Phe Thr Ala Met Arg Asp Gln Tyr Met Arg Ala Gly Glu Gly Phe 
                85                  90                  95      


Ile Ile Cys Tyr Ser Ile Thr Asp Arg Arg Ser Phe His Glu Val Arg 
            100                 105                 110         


Glu Phe Lys Gln Leu Ile Tyr Arg Val Arg Arg Thr Asp Asp Thr Pro 
        115                 120                 125             


Val Val Leu Val Gly Asn Lys Ser Asp Leu Lys Gln Leu Arg Gln Val 
    130                 135                 140                 


Thr Lys Glu Glu Gly Leu Ala Leu Ala Arg Glu Phe Ser Cys Pro Phe 
145                 150                 155                 160 


Phe Glu Thr Ser Ala Ala Tyr Arg Tyr Tyr Ile Asp Asp Val Phe His 
                165                 170                 175     


Ala Leu Val Arg Glu Ile Arg Arg Lys Glu Lys Glu Ala Val Leu Ala 
            180                 185                 190         


Met Glu Lys Lys Ser Lys Pro Lys Asn Ser Val Trp Lys Arg Leu Lys 
        195                 200                 205             


Ser Pro Phe Arg Lys Lys Lys Asp Ser Val Thr 
    210                 215                 


<210>  1227
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  1227

Met Gly Ala Tyr Lys Tyr Ile Gln Glu Leu Trp Arg Lys Lys Gln Ser 
1               5                   10                  15      


Asp Val Met Arg Phe Leu Leu Arg Val Arg Cys Trp Gln Tyr Arg Gln 
            20                  25                  30          


Leu Ser Ala Leu His Arg Ala Pro Arg Pro Thr Arg Pro Asp Lys Ala 
        35                  40                  45              


Arg Arg Leu Gly Tyr Lys Ala Lys Gln Gly Tyr Val Ile Tyr Arg Ile 
    50                  55                  60                  


Arg Val Arg Arg Gly Gly Arg Lys Arg Pro Val Pro Lys Gly Ala Thr 
65                  70                  75                  80  


Tyr Gly Lys Pro Val His His Gly Val Asn Gln Leu Lys Phe Ala Arg 
                85                  90                  95      


Ser Leu Gln Ser Val Ala Glu Glu Arg Ala Gly Arg His Cys Gly Ala 
            100                 105                 110         


Leu Arg Val Leu Asn Ser Tyr Trp Val Gly Glu Asp Ser Thr Tyr Lys 
        115                 120                 125             


Phe Phe Glu Val Ile Leu Ile Asp Pro Phe His Lys Ala Ile Arg Arg 
    130                 135                 140                 


Asn Pro Asp Thr Gln Trp Ile Thr Lys Pro Val His Lys His Arg Glu 
145                 150                 155                 160 


Met Arg Gly Leu Thr Ser Ala Gly Arg Lys Ser Arg Gly Leu Gly Lys 
                165                 170                 175     


Gly His Lys Phe His His Thr Ile Gly Gly Ser Arg Arg Ala Ala Trp 
            180                 185                 190         


Arg Arg Arg Asn Thr Leu Gln Leu His Arg Tyr Arg 
        195                 200                 


<210>  1228
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  1228

Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys 
1               5                   10                  15      


Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly 
            20                  25                  30          


Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys 
        35                  40                  45              


Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu 
    50                  55                  60                  


Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys 
65                  70                  75                  80  


Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu 
                85                  90                  95      


Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu 
            100                 105                 110         


Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp 
        115                 120                 125             


<210>  1229
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  1229

Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile Pro Glu Asn Val 
1               5                   10                  15      


Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys Gly Pro Arg Gly 
            20                  25                  30          


Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu Ser Leu Leu 
        35                  40                  45              


Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Trp Gly Asn Arg 
    50                  55                  60                  


Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His Val Gln Asn Met 
65                  70                  75                  80  


Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met Arg Ser Val Tyr 
                85                  90                  95      


Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn Gly Ser Leu Val 
            100                 105                 110         


Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg Arg Val Arg Met 
        115                 120                 125             


Arg Pro Gly Val Ala Cys Ser Val Ser Gln Ala Gln Lys Asp Glu Leu 
    130                 135                 140                 


Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn Ser Ala Ala Leu 
145                 150                 155                 160 


Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile Arg Lys Phe Leu 
                165                 170                 175     


Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln Gln Ala Asp Glu 
            180                 185                 190         


<210>  1230
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  1230

Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser 
1               5                   10                  15      


Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His 
            20                  25                  30          


Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser 
        35                  40                  45              


Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala 
    50                  55                  60                  


Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp 
65                  70                  75                  80  


Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys 
                85                  90                  95      


Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala 
            100                 105                 110         


Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg 
        115                 120                 125             


Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly 
    130                 135                 140                 


Gly Arg Arg Gly Arg Arg Leu 
145                 150     


<210>  1231
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  1231

Met Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys 
1               5                   10                  15      


His Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser 
            20                  25                  30          


Thr Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu 
        35                  40                  45              


Arg Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile 
    50                  55                  60                  


Cys Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile 
65                  70                  75                  80  


Thr Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly 
                85                  90                  95      


Glu Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His 
            100                 105                 110         


Arg Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys 
        115                 120                 125             


Ile Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala 
    130                 135                 140                 


Arg Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile 
145                 150                 155                 160 


Gln Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp 
                165                 170                 175     


Thr Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile 
            180                 185                 190         


Gly Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val 
        195                 200                 205             


His Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn 
    210                 215                 220                 


Ile Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg 
225                 230                 235                 240 


Gly Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu 
                245                 250                 255     


Ala Ala Lys Gln Ser Ser Gly 
            260             


<210>  1232
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1232

Met Asp Gly Gln Lys Lys Asn Trp Lys Asp Lys Val Val Asp Leu Leu 
1               5                   10                  15      


Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val Val Phe Gly Ala Ser Leu 
            20                  25                  30          


Phe Leu Leu Leu Ser Leu Thr Val Phe Ser Ile Val Ser Val Thr Ala 
        35                  40                  45              


Tyr Ile Ala Leu Ala Leu Leu Ser Val Thr Ile Ser Phe Arg Ile Tyr 
    50                  55                  60                  


Lys Gly Val Ile Gln Ala Ile Gln Lys Ser Asp Glu Gly His Pro Phe 
65                  70                  75                  80  


Arg Ala Tyr Leu Glu Ser Glu Val Ala Ile Ser Glu Glu Leu Val Gln 
                85                  90                  95      


Lys Tyr Ser Asn Ser Ala Leu Gly His Val Asn Cys Thr Ile Lys Glu 
            100                 105                 110         


Leu Arg Arg Leu Phe Leu Val Asp Asp Leu Val Asp Ser Leu Lys Phe 
        115                 120                 125             


Ala Val Leu Met Trp Val Phe Thr Tyr Val Gly Ala Leu Phe Asn Gly 
    130                 135                 140                 


Leu Thr Leu Leu Ile Leu Ala Leu Ile Ser Leu Phe Ser Val Pro Val 
145                 150                 155                 160 


Ile Tyr Glu Arg His Gln Ala Gln Ile Asp His Tyr Leu Gly Leu Ala 
                165                 170                 175     


Asn Lys Asn Val Lys Asp Ala Met Ala Lys Ile Gln Ala Lys Ile Pro 
            180                 185                 190         


Gly Leu Lys Arg Lys Ala Glu 
        195                 


<210>  1233
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1233

Met Phe Val Ala Arg Ser Ile Ala Ala Asp His Lys Asp Leu Ile His 
1               5                   10                  15      


Asp Val Ser Phe Asp Phe His Gly Arg Arg Met Ala Thr Cys Ser Ser 
            20                  25                  30          


Asp Gln Ser Val Lys Val Trp Asp Lys Ser Glu Ser Gly Asp Trp His 
        35                  40                  45              


Cys Thr Ala Ser Trp Lys Thr His Ser Gly Ser Val Trp Arg Val Thr 
    50                  55                  60                  


Trp Ala His Pro Glu Phe Gly Gln Val Leu Ala Ser Cys Ser Phe Asp 
65                  70                  75                  80  


Arg Thr Ala Ala Val Trp Glu Glu Ile Val Gly Glu Ser Asn Asp Lys 
                85                  90                  95      


Leu Arg Gly Gln Ser His Trp Val Lys Arg Thr Thr Leu Val Asp Ser 
            100                 105                 110         


Arg Thr Ser Val Thr Asp Val Lys Phe Ala Pro Lys His Met Gly Leu 
        115                 120                 125             


Met Leu Ala Thr Cys Ser Ala Asp Gly Ile Val Arg Ile Tyr Glu Ala 
    130                 135                 140                 


Pro Asp Val Met Asn Leu Ser Gln Trp Ser Leu Gln His Glu Ile Ser 
145                 150                 155                 160 


Cys Lys Leu Ser Cys Ser Cys Ile Ser Trp Asn Pro Ser Ser Ser Arg 
                165                 170                 175     


Ala His Ser Pro Met Ile Ala Val Gly Ser Asp Asp Ser Ser Pro Asn 
            180                 185                 190         


Ala Met Ala Lys Val Gln Ile Phe Glu Tyr Asn Glu Asn Thr Arg Lys 
        195                 200                 205             


Tyr Ala Lys Ala Glu Thr Leu Met Thr Val Thr Asp Pro Val His Asp 
    210                 215                 220                 


Ile Ala Phe Ala Pro Asn Leu Gly Arg Ser Phe His Ile Leu Ala Ile 
225                 230                 235                 240 


Ala Thr Lys Asp Val Arg Ile Phe Thr Leu Lys Pro Val Arg Lys Glu 
                245                 250                 255     


Leu Thr Ser Ser Gly Gly Pro Thr Lys Phe Glu Ile His Ile Val Ala 
            260                 265                 270         


Gln Phe Asp Asn His Asn Ser Gln Val Trp Arg Val Ser Trp Asn Ile 
        275                 280                 285             


Thr Gly Thr Val Leu Ala Ser Ser Gly Asp Asp Gly Cys Val Arg Leu 
    290                 295                 300                 


Trp Lys Ala Asn Tyr Met Asp Asn Trp Lys Cys Thr Gly Ile Leu Lys 
305                 310                 315                 320 


Gly Asn Gly Ser Pro Val Asn Gly Ser Ser Gln Gln Gly Thr Ser Asn 
                325                 330                 335     


Pro Ser Leu Gly Ser Thr Ile Pro Ser Leu Gln Asn Ser Leu Asn Gly 
            340                 345                 350         


Ser Ser Ala Gly Arg Lys His Ser 
        355                 360 


<210>  1234
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  1234

Met Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg 
1               5                   10                  15      


Phe Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys 
            20                  25                  30          


Ala Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly 
        35                  40                  45              


Pro Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn 
    50                  55                  60                  


Ala Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn 
65                  70                  75                  80  


Pro Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln 
                85                  90                  95      


Pro Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg 
            100                 105                 110         


Pro Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro 
        115                 120                 125             


Glu Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu 
    130                 135                 140                 


Lys Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg 
145                 150                 155                 160 


Pro Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly 
                165                 170                 175     


Arg Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu 
            180                 185                 190         


Phe Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp 
        195                 200                 205             


Lys Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu 
    210                 215                 220                 


Leu Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly 
225                 230                 235                 240 


Glu Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val 
                245                 250                 255     


Glu Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp 
            260                 265                 270         


Lys Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg 
        275                 280                 285             


Lys Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu 
    290                 295                 300                 


His Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp 
305                 310                 315                 320 


His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg 
            340                 345                 350         


Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp 
        355                 360                 365             


Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro 
    370                 375                 380                 


Ala Leu Ala 
385         


<210>  1235
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  1235

Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe 
1               5                   10                  15      


Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro 
            20                  25                  30          


Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly 
        35                  40                  45              


Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu 
    50                  55                  60                  


Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg 
65                  70                  75                  80  


Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys 
                85                  90                  95      


Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr 
            100                 105                 110         


Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala 
        115                 120                 125             


Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile 
    130                 135                 140                 


Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met 
                165                 170                 175     


Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg 
            180                 185                 190         


Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr 
        195                 200                 205             


Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu 
    210                 215                 220                 


Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His 
                245                 250                 255     


Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser 
            260                 265                 270         


Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu 
        275                 280                 285             


Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu 
    290                 295                 300                 


Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His 
305                 310                 315                 320 


Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala 
                325                 330                 335     


Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe 
            340                 345                 350         


Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly 
        355                 360                 365             


Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro 
    370                 375                 


<210>  1236
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  1236

Met Leu Gly Lys Gly Gly Lys Arg Lys Phe Asp Glu His Glu Asp Gly 
1               5                   10                  15      


Leu Glu Gly Lys Ile Val Ser Pro Cys Asp Gly Pro Ser Lys Val Ser 
            20                  25                  30          


Tyr Thr Leu Gln Arg Gln Thr Ile Phe Asn Ile Ser Leu Met Lys Leu 
        35                  40                  45              


Tyr Asn His Arg Pro Leu Thr Glu Pro Ser Leu Gln Lys Thr Val Leu 
    50                  55                  60                  


Ile Asn Asn Met Leu Arg Arg Ile Gln Glu Glu Leu Lys Gln Glu Gly 
65                  70                  75                  80  


Ser Leu Arg Pro Met Phe Thr Pro Ser Ser Gln Pro Thr Thr Glu Pro 
                85                  90                  95      


Ser Asp Ser Tyr Arg Glu Ala Pro Pro Ala Phe Ser His Leu Ala Ser 
            100                 105                 110         


Pro Ser Ser His Pro Cys Asp Leu Gly Ser Thr Thr Pro Leu Glu Ala 
        115                 120                 125             


Cys Leu Thr Pro Ala Ser Leu Leu Glu Asp Asp Asp Asp Thr Phe Cys 
    130                 135                 140                 


Thr Ser Gln Ala Met Gln Pro Thr Ala Pro Thr Lys Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Leu Leu Pro Glu Lys Asp Ser Phe Ser Ser Ala Leu Asp Glu Ile 
                165                 170                 175     


Glu Glu Leu Cys Pro Thr Ser Thr Ser Thr Glu Ala Ala Thr Ala Ala 
            180                 185                 190         


Thr Asp Ser Val Lys Gly Thr Ser Ser Glu Ala Gly Thr Gln Lys Leu 
        195                 200                 205             


Asp Gly Pro Gln Glu Ser Arg Ala Asp Asp Ser Lys Leu Met Asp Ser 
    210                 215                 220                 


Leu Pro Gly Asn Phe Glu Ile Thr Thr Ser Thr Gly Phe Leu Thr Asp 
225                 230                 235                 240 


Leu Thr Leu Asp Asp Ile Leu Phe Ala Asp Ile Asp Thr Ser Met Tyr 
                245                 250                 255     


Asp Phe Asp Pro Cys Thr Ser Ser Ser Gly Thr Ala Ser Lys Met Ala 
            260                 265                 270         


Pro Val Ser Ala Asp Asp Leu Leu Lys Thr Leu Ala Pro Tyr Ser Ser 
        275                 280                 285             


Gln Pro Val Thr Pro Ser Gln Pro Phe Lys Met Asp Leu Thr Glu Leu 
    290                 295                 300                 


Asp His Ile Met Glu Val Leu Val Gly Ser 
305                 310                 


<210>  1237
<211>  2677
<212>  PRT
<213>  Homo sapiens

<400>  1237

Met Ser Thr Cys Cys Trp Cys Thr Pro Gly Gly Ala Ser Thr Ile Asp 
1               5                   10                  15      


Phe Leu Lys Arg Tyr Ala Ser Asn Thr Pro Ser Gly Glu Phe Gln Thr 
            20                  25                  30          


Ala Asp Glu Asp Leu Cys Tyr Cys Leu Glu Cys Val Ala Glu Tyr His 
        35                  40                  45              


Lys Ala Arg Asp Glu Leu Pro Phe Leu His Glu Val Leu Trp Glu Leu 
    50                  55                  60                  


Glu Thr Leu Arg Leu Ile Asn His Phe Glu Lys Ser Met Lys Ala Glu 
65                  70                  75                  80  


Ile Gly Asp Asp Asp Glu Leu Tyr Ile Val Asp Asn Asn Gly Glu Met 
                85                  90                  95      


Pro Leu Phe Asp Ile Thr Gly Gln Asp Phe Glu Asn Lys Leu Arg Val 
            100                 105                 110         


Pro Leu Leu Glu Ile Leu Lys Tyr Pro Tyr Leu Leu Leu His Glu Arg 
        115                 120                 125             


Val Asn Glu Leu Cys Val Glu Ala Leu Cys Arg Met Glu Gln Ala Asn 
    130                 135                 140                 


Cys Ser Phe Gln Val Phe Asp Lys His Pro Gly Ile Tyr Leu Phe Leu 
145                 150                 155                 160 


Val His Pro Asn Glu Met Val Arg Arg Trp Ala Ile Leu Thr Ala Arg 
                165                 170                 175     


Asn Leu Gly Lys Val Asp Arg Asp Asp Tyr Tyr Asp Leu Gln Glu Val 
            180                 185                 190         


Leu Leu Cys Leu Phe Lys Val Ile Glu Leu Gly Leu Leu Glu Ser Pro 
        195                 200                 205             


Asp Ile Tyr Thr Ser Ser Val Leu Glu Lys Gly Lys Leu Ile Leu Leu 
    210                 215                 220                 


Pro Ser His Met Tyr Asp Thr Thr Asn Tyr Lys Ser Tyr Trp Leu Gly 
225                 230                 235                 240 


Ile Cys Met Leu Leu Thr Ile Leu Glu Glu Gln Ala Met Asp Ser Leu 
                245                 250                 255     


Leu Leu Gly Ser Asp Lys Gln Asn Asp Phe Met Gln Ser Ile Leu His 
            260                 265                 270         


Thr Met Glu Arg Glu Ala Asp Asp Asp Ser Val Asp Pro Phe Trp Pro 
        275                 280                 285             


Ala Leu His Cys Phe Met Val Ile Leu Asp Arg Leu Gly Ser Lys Val 
    290                 295                 300                 


Trp Gly Gln Leu Met Asp Pro Ile Val Ala Phe Gln Thr Ile Ile Asn 
305                 310                 315                 320 


Asn Ala Ser Tyr Asn Arg Glu Ile Arg His Ile Arg Asn Ser Ser Val 
                325                 330                 335     


Arg Thr Lys Leu Glu Pro Glu Ser Tyr Leu Asp Asp Met Val Thr Cys 
            340                 345                 350         


Ser Gln Ile Val Tyr Asn Tyr Asn Pro Glu Lys Thr Lys Lys Asp Ser 
        355                 360                 365             


Gly Trp Arg Thr Ala Ile Cys Pro Asp Tyr Cys Pro Asn Met Tyr Glu 
    370                 375                 380                 


Glu Met Glu Thr Leu Ala Ser Val Leu Gln Ser Asp Ile Gly Gln Asp 
385                 390                 395                 400 


Met Arg Val His Asn Ser Thr Phe Leu Trp Phe Ile Pro Phe Val Gln 
                405                 410                 415     


Ser Leu Met Asp Leu Lys Asp Leu Gly Val Ala Tyr Ile Ala Gln Val 
            420                 425                 430         


Val Asn His Leu Tyr Ser Glu Val Lys Glu Val Leu Asn Gln Thr Asp 
        435                 440                 445             


Ala Val Cys Asp Lys Val Thr Glu Phe Phe Leu Leu Ile Leu Val Ser 
    450                 455                 460                 


Val Ile Glu Leu His Arg Asn Lys Lys Cys Leu His Leu Leu Trp Val 
465                 470                 475                 480 


Ser Ser Gln Gln Trp Val Glu Ala Val Val Lys Cys Ala Lys Leu Pro 
                485                 490                 495     


Thr Thr Ala Phe Thr Arg Ser Ser Glu Lys Ser Ser Gly Asn Cys Ser 
            500                 505                 510         


Lys Gly Thr Ala Met Ile Ser Ser Leu Ser Leu His Ser Met Pro Ser 
        515                 520                 525             


Asn Ser Val Gln Leu Ala Tyr Val Gln Leu Ile Arg Ser Leu Leu Lys 
    530                 535                 540                 


Glu Gly Tyr Gln Leu Gly Gln Gln Ser Leu Cys Lys Arg Phe Trp Asp 
545                 550                 555                 560 


Lys Leu Asn Leu Phe Leu Arg Gly Asn Leu Ser Leu Gly Trp Gln Leu 
                565                 570                 575     


Thr Ser Gln Glu Thr His Glu Leu Gln Ser Cys Leu Lys Gln Ile Ile 
            580                 585                 590         


Arg Asn Ile Lys Phe Lys Ala Pro Pro Cys Asn Thr Phe Val Asp Leu 
        595                 600                 605             


Thr Ser Ala Cys Lys Ile Ser Pro Ala Ser Tyr Asn Lys Glu Glu Ser 
    610                 615                 620                 


Glu Gln Met Gly Lys Thr Ser Arg Lys Asp Met His Cys Leu Glu Ala 
625                 630                 635                 640 


Ser Ser Pro Thr Phe Ser Lys Glu Pro Met Lys Val Gln Asp Ser Val 
                645                 650                 655     


Leu Ile Lys Ala Asp Asn Thr Ile Glu Gly Asp Asn Asn Glu Gln Asn 
            660                 665                 670         


Tyr Ile Lys Asp Val Lys Leu Glu Asp His Leu Leu Ala Gly Ser Cys 
        675                 680                 685             


Leu Lys Gln Ser Ser Lys Asn Ile Phe Thr Glu Arg Ala Glu Asp Gln 
    690                 695                 700                 


Ile Lys Ile Ser Thr Arg Lys Gln Lys Ser Val Lys Glu Ile Ser Ser 
705                 710                 715                 720 


Tyr Thr Pro Lys Asp Cys Thr Ser Arg Asn Gly Pro Glu Arg Gly Cys 
                725                 730                 735     


Asp Arg Gly Ile Ile Val Ser Thr Arg Leu Leu Thr Asp Ser Ser Thr 
            740                 745                 750         


Asp Ala Leu Glu Lys Val Ser Thr Ser Asn Glu Asp Phe Ser Leu Lys 
        755                 760                 765             


Asp Asp Ala Leu Ala Lys Thr Ser Lys Arg Lys Thr Lys Val Gln Lys 
    770                 775                 780                 


Asp Glu Ile Cys Ala Lys Leu Ser His Val Ile Lys Lys Gln His Arg 
785                 790                 795                 800 


Lys Ser Thr Leu Val Asp Asn Thr Ile Asn Leu Asp Glu Asn Leu Thr 
                805                 810                 815     


Val Ser Asn Ile Glu Ser Phe Tyr Ser Arg Lys Asp Thr Gly Val Gln 
            820                 825                 830         


Lys Gly Asp Gly Phe Ile His Asn Leu Ser Leu Asp Pro Ser Gly Val 
        835                 840                 845             


Leu Asp Asp Lys Asn Gly Glu Gln Lys Ser Gln Asn Asn Val Leu Pro 
    850                 855                 860                 


Lys Glu Lys Gln Leu Lys Asn Glu Glu Leu Val Ile Phe Ser Phe His 
865                 870                 875                 880 


Glu Asn Asn Cys Lys Ile Gln Glu Phe His Val Asp Gly Lys Glu Leu 
                885                 890                 895     


Ile Pro Phe Thr Glu Met Thr Asn Ala Ser Glu Lys Lys Ser Ser Pro 
            900                 905                 910         


Phe Lys Asp Leu Met Thr Val Pro Glu Ser Arg Asp Glu Glu Met Ser 
        915                 920                 925             


Asn Ser Thr Ser Val Ile Tyr Ser Asn Leu Thr Arg Glu Gln Ala Pro 
    930                 935                 940                 


Asp Ile Ser Pro Lys Ser Asp Thr Leu Thr Asp Ser Gln Ile Asp Arg 
945                 950                 955                 960 


Asp Leu His Lys Leu Ser Leu Leu Ala Gln Ala Ser Val Ile Thr Phe 
                965                 970                 975     


Pro Ser Asp Ser Pro Gln Asn Ser Ser Gln Leu Gln Arg Lys Val Lys 
            980                 985                 990         


Glu Asp Lys Arg Cys Phe Thr Ala  Asn Gln Asn Asn Val  Gly Asp Thr 
        995                 1000                 1005             


Ser Arg  Gly Gln Val Ile Ile  Ile Ser Asp Ser Asp  Asp Asp Asp 
    1010                 1015                 1020             


Asp Glu  Arg Ile Leu Ser Leu  Glu Lys Leu Thr Lys  Gln Asp Lys 
    1025                 1030                 1035             


Ile Cys  Leu Glu Arg Glu His  Pro Glu Gln His Val  Ser Thr Val 
    1040                 1045                 1050             


Asn Ser  Lys Glu Glu Lys Asn  Pro Val Lys Glu Glu  Lys Thr Glu 
    1055                 1060                 1065             


Thr Leu  Phe Gln Phe Glu Glu  Ser Asp Ser Gln Cys  Phe Glu Phe 
    1070                 1075                 1080             


Glu Ser  Ser Ser Glu Val Phe  Ser Val Trp Gln Asp  His Pro Asp 
    1085                 1090                 1095             


Asp Asn  Asn Ser Val Gln Asp  Gly Glu Lys Lys Cys  Leu Ala Pro 
    1100                 1105                 1110             


Ile Ala  Asn Thr Thr Asn Gly  Gln Gly Cys Thr Asp  Tyr Val Ser 
    1115                 1120                 1125             


Glu Val  Val Lys Lys Gly Ala  Glu Gly Ile Glu Glu  His Thr Arg 
    1130                 1135                 1140             


Pro Arg  Ser Ile Ser Val Glu  Glu Phe Cys Glu Ile  Glu Val Lys 
    1145                 1150                 1155             


Lys Pro  Lys Arg Lys Arg Ser  Glu Lys Pro Met Ala  Glu Asp Pro 
    1160                 1165                 1170             


Val Arg  Pro Ser Ser Ser Val  Arg Asn Glu Gly Gln  Ser Asp Thr 
    1175                 1180                 1185             


Asn Lys  Arg Asp Leu Val Gly  Asn Asp Phe Lys Ser  Ile Asp Arg 
    1190                 1195                 1200             


Arg Thr  Ser Thr Pro Asn Ser  Arg Ile Gln Arg Ala  Thr Thr Val 
    1205                 1210                 1215             


Ser Gln  Lys Lys Ser Ser Lys  Leu Cys Thr Cys Thr  Glu Pro Ile 
    1220                 1225                 1230             


Arg Lys  Val Pro Val Ser Lys  Thr Pro Lys Lys Thr  His Ser Asp 
    1235                 1240                 1245             


Ala Lys  Lys Gly Gln Asn Arg  Ser Ser Asn Tyr Leu  Ser Cys Arg 
    1250                 1255                 1260             


Thr Thr  Pro Ala Ile Val Pro  Pro Lys Lys Phe Arg  Gln Cys Pro 
    1265                 1270                 1275             


Glu Pro  Thr Ser Thr Ala Glu  Lys Leu Gly Leu Lys  Lys Gly Pro 
    1280                 1285                 1290             


Arg Lys  Ala Tyr Glu Leu Ser  Gln Arg Ser Leu Asp  Tyr Val Ala 
    1295                 1300                 1305             


Gln Leu  Arg Asp His Gly Lys  Thr Val Gly Val Val  Asp Thr Arg 
    1310                 1315                 1320             


Lys Lys  Thr Lys Leu Ile Ser  Pro Gln Asn Leu Ser  Val Arg Asn 
    1325                 1330                 1335             


Asn Lys  Lys Leu Leu Thr Ser  Gln Glu Leu Gln Met  Gln Arg Gln 
    1340                 1345                 1350             


Ile Arg  Pro Lys Ser Gln Lys  Asn Arg Arg Arg Leu  Ser Asp Cys 
    1355                 1360                 1365             


Glu Ser  Thr Asp Val Lys Arg  Ala Gly Ser His Thr  Ala Gln Asn 
    1370                 1375                 1380             


Ser Asp  Ile Phe Val Pro Glu  Ser Asp Arg Ser Asp  Tyr Asn Cys 
    1385                 1390                 1395             


Thr Gly  Gly Thr Glu Val Leu  Ala Asn Ser Asn Arg  Lys Gln Leu 
    1400                 1405                 1410             


Ile Lys  Cys Met Pro Ser Glu  Pro Glu Thr Ile Lys  Ala Lys His 
    1415                 1420                 1425             


Gly Ser  Pro Ala Thr Asp Asp  Ala Cys Pro Leu Asn  Gln Cys Asp 
    1430                 1435                 1440             


Ser Val  Val Leu Asn Gly Thr  Val Pro Thr Asn Glu  Val Ile Val 
    1445                 1450                 1455             


Ser Thr  Ser Glu Asp Pro Leu  Gly Gly Gly Asp Pro  Thr Ala Arg 
    1460                 1465                 1470             


His Ile  Glu Met Ala Ala Leu  Lys Glu Gly Glu Pro  Asp Ser Ser 
    1475                 1480                 1485             


Ser Asp  Ala Glu Glu Asp Asn  Leu Phe Leu Thr Gln  Asn Asp Pro 
    1490                 1495                 1500             


Glu Asp  Met Asp Leu Cys Ser  Gln Met Glu Asn Asp  Asn Tyr Lys 
    1505                 1510                 1515             


Leu Ile  Glu Leu Ile His Gly  Lys Asp Thr Val Glu  Val Glu Glu 
    1520                 1525                 1530             


Asp Ser  Val Ser Arg Pro Gln  Leu Glu Ser Leu Ser  Gly Thr Lys 
    1535                 1540                 1545             


Cys Lys  Tyr Lys Asp Cys Leu  Glu Thr Thr Lys Asn  Gln Gly Glu 
    1550                 1555                 1560             


Tyr Cys  Pro Lys His Ser Glu  Val Lys Ala Ala Asp  Glu Asp Val 
    1565                 1570                 1575             


Phe Arg  Lys Pro Gly Leu Pro  Pro Pro Ala Ser Lys  Pro Leu Arg 
    1580                 1585                 1590             


Pro Thr  Thr Lys Ile Phe Ser  Ser Lys Ser Thr Ser  Arg Ile Ala 
    1595                 1600                 1605             


Gly Leu  Ser Lys Ser Leu Glu  Thr Ser Ser Ala Leu  Ser Pro Ser 
    1610                 1615                 1620             


Leu Lys  Asn Lys Ser Lys Gly  Ile Gln Ser Ile Leu  Lys Val Pro 
    1625                 1630                 1635             


Gln Pro  Val Pro Leu Ile Ala  Gln Lys Pro Val Gly  Glu Met Lys 
    1640                 1645                 1650             


Asn Ser  Cys Asn Val Leu His  Pro Gln Ser Pro Asn  Asn Ser Asn 
    1655                 1660                 1665             


Arg Gln  Gly Cys Lys Val Pro  Phe Gly Glu Ser Lys  Tyr Phe Pro 
    1670                 1675                 1680             


Ser Ser  Ser Pro Val Asn Ile  Leu Leu Ser Ser Gln  Ser Val Ser 
    1685                 1690                 1695             


Asp Thr  Phe Val Lys Glu Val  Leu Lys Trp Lys Tyr  Glu Met Phe 
    1700                 1705                 1710             


Leu Asn  Phe Gly Gln Cys Gly  Pro Pro Ala Ser Leu  Cys Gln Ser 
    1715                 1720                 1725             


Ile Ser  Arg Pro Val Pro Val  Arg Phe His Asn Tyr  Gly Asp Tyr 
    1730                 1735                 1740             


Phe Asn  Val Phe Phe Pro Leu  Met Val Leu Asn Thr  Phe Glu Thr 
    1745                 1750                 1755             


Val Ala  Gln Glu Trp Leu Asn  Ser Pro Asn Arg Glu  Asn Phe Tyr 
    1760                 1765                 1770             


Gln Leu  Gln Val Arg Lys Phe  Pro Ala Asp Tyr Ile  Lys Tyr Trp 
    1775                 1780                 1785             


Glu Phe  Ala Val Tyr Leu Glu  Glu Cys Glu Leu Ala  Lys Gln Leu 
    1790                 1795                 1800             


Tyr Pro  Lys Glu Asn Asp Leu  Val Phe Leu Ala Pro  Glu Arg Ile 
    1805                 1810                 1815             


Asn Glu  Glu Lys Lys Asp Thr  Glu Arg Asn Asp Ile  Gln Asp Leu 
    1820                 1825                 1830             


His Glu  Tyr His Ser Gly Tyr  Val His Lys Phe Arg  Arg Thr Ser 
    1835                 1840                 1845             


Val Met  Arg Asn Gly Lys Thr  Glu Cys Tyr Leu Ser  Ile Gln Thr 
    1850                 1855                 1860             


Gln Glu  Asn Phe Pro Ala Asn  Leu Asn Glu Leu Val  Asn Cys Ile 
    1865                 1870                 1875             


Val Ile  Ser Ser Leu Val Thr  Thr Gln Arg Lys Leu  Lys Ala Met 
    1880                 1885                 1890             


Ser Leu  Leu Gly Ser Arg Asn  Gln Leu Ala Arg Ala  Val Leu Asn 
    1895                 1900                 1905             


Pro Asn  Pro Met Asp Phe Cys  Thr Lys Asp Leu Leu  Thr Thr Thr 
    1910                 1915                 1920             


Ser Glu  Arg Ile Ile Ala Tyr  Leu Arg Asp Phe Asn  Glu Asp Gln 
    1925                 1930                 1935             


Lys Lys  Ala Ile Glu Thr Ala  Tyr Ala Met Val Lys  His Ser Pro 
    1940                 1945                 1950             


Ser Val  Ala Lys Ile Cys Leu  Ile His Gly Pro Pro  Gly Thr Gly 
    1955                 1960                 1965             


Lys Ser  Lys Thr Ile Val Gly  Leu Leu Tyr Arg Leu  Leu Thr Glu 
    1970                 1975                 1980             


Asn Gln  Arg Lys Gly His Ser  Asp Glu Asn Ser Asn  Ala Lys Ile 
    1985                 1990                 1995             


Lys Gln  Asn Arg Val Leu Val  Cys Ala Pro Ser Asn  Ala Ala Val 
    2000                 2005                 2010             


Asp Glu  Leu Met Lys Lys Ile  Ile Leu Glu Phe Lys  Glu Lys Cys 
    2015                 2020                 2025             


Lys Asp  Lys Lys Asn Pro Leu  Gly Asn Cys Gly Asp  Ile Asn Leu 
    2030                 2035                 2040             


Val Arg  Leu Gly Pro Glu Lys  Ser Ile Asn Ser Glu  Val Leu Lys 
    2045                 2050                 2055             


Phe Ser  Leu Asp Ser Gln Val  Asn His Arg Met Lys  Lys Glu Leu 
    2060                 2065                 2070             


Pro Ser  His Val Gln Ala Met  His Lys Arg Lys Glu  Phe Leu Asp 
    2075                 2080                 2085             


Tyr Gln  Leu Asp Glu Leu Ser  Arg Gln Arg Ala Leu  Cys Arg Gly 
    2090                 2095                 2100             


Gly Arg  Glu Ile Gln Arg Gln  Glu Leu Asp Glu Asn  Ile Ser Lys 
    2105                 2110                 2115             


Val Ser  Lys Glu Arg Gln Glu  Leu Ala Ser Lys Ile  Lys Glu Val 
    2120                 2125                 2130             


Gln Gly  Arg Pro Gln Lys Thr  Gln Ser Ile Ile Ile  Leu Glu Ser 
    2135                 2140                 2145             


His Ile  Ile Cys Cys Thr Leu  Ser Thr Ser Gly Gly  Leu Leu Leu 
    2150                 2155                 2160             


Glu Ser  Ala Phe Arg Gly Gln  Gly Gly Val Pro Phe  Ser Cys Val 
    2165                 2170                 2175             


Ile Val  Asp Glu Ala Gly Gln  Ser Cys Glu Ile Glu  Thr Leu Thr 
    2180                 2185                 2190             


Pro Leu  Ile His Arg Cys Asn  Lys Leu Ile Leu Val  Gly Asp Pro 
    2195                 2200                 2205             


Lys Gln  Leu Pro Pro Thr Val  Ile Ser Met Lys Ala  Gln Glu Tyr 
    2210                 2215                 2220             


Gly Tyr  Asp Gln Ser Met Met  Ala Arg Phe Cys Arg  Leu Leu Glu 
    2225                 2230                 2235             


Glu Asn  Val Glu His Asn Met  Ile Ser Arg Leu Pro  Ile Leu Gln 
    2240                 2245                 2250             


Leu Thr  Val Gln Tyr Arg Met  His Pro Asp Ile Cys  Leu Phe Pro 
    2255                 2260                 2265             


Ser Asn  Tyr Val Tyr Asn Arg  Asn Leu Lys Thr Asn  Arg Gln Thr 
    2270                 2275                 2280             


Glu Ala  Ile Arg Cys Ser Ser  Asp Trp Pro Phe Gln  Pro Tyr Leu 
    2285                 2290                 2295             


Val Phe  Asp Val Gly Asp Gly  Ser Glu Arg Arg Asp  Asn Asp Ser 
    2300                 2305                 2310             


Tyr Ile  Asn Val Gln Glu Ile  Lys Leu Val Met Glu  Ile Ile Lys 
    2315                 2320                 2325             


Leu Ile  Lys Asp Lys Arg Lys  Asp Val Ser Phe Arg  Asn Ile Gly 
    2330                 2335                 2340             


Ile Ile  Thr His Tyr Lys Ala  Gln Lys Thr Met Ile  Gln Lys Asp 
    2345                 2350                 2355             


Leu Asp  Lys Glu Phe Asp Arg  Lys Gly Pro Ala Glu  Val Asp Thr 
    2360                 2365                 2370             


Val Asp  Ala Phe Gln Gly Arg  Gln Lys Asp Cys Val  Ile Val Thr 
    2375                 2380                 2385             


Cys Val  Arg Ala Asn Ser Ile  Gln Gly Ser Ile Gly  Phe Leu Ala 
    2390                 2395                 2400             


Ser Leu  Gln Arg Leu Asn Val  Thr Ile Thr Arg Ala  Lys Tyr Ser 
    2405                 2410                 2415             


Leu Phe  Ile Leu Gly His Leu  Arg Thr Leu Met Glu  Asn Gln His 
    2420                 2425                 2430             


Trp Asn  Gln Leu Ile Gln Asp  Ala Gln Lys Arg Gly  Ala Ile Ile 
    2435                 2440                 2445             


Lys Thr  Cys Asp Lys Asn Tyr  Arg His Asp Ala Val  Lys Ile Leu 
    2450                 2455                 2460             


Lys Leu  Lys Pro Val Leu Gln  Arg Ser Leu Thr His  Pro Pro Thr 
    2465                 2470                 2475             


Ile Ala  Pro Glu Gly Ser Arg  Pro Gln Gly Gly Leu  Pro Ser Ser 
    2480                 2485                 2490             


Lys Leu  Asp Ser Gly Phe Ala  Lys Thr Ser Val Ala  Ala Ser Leu 
    2495                 2500                 2505             


Tyr His  Thr Pro Ser Asp Ser  Lys Glu Ile Thr Leu  Thr Val Thr 
    2510                 2515                 2520             


Ser Lys  Asp Pro Glu Arg Pro  Pro Val His Asp Gln  Leu Gln Asp 
    2525                 2530                 2535             


Pro Arg  Leu Leu Lys Arg Met  Gly Ile Glu Val Lys  Gly Gly Ile 
    2540                 2545                 2550             


Phe Leu  Trp Asp Pro Gln Pro  Ser Ser Pro Gln His  Pro Gly Ala 
    2555                 2560                 2565             


Thr Pro  Pro Thr Gly Glu Pro  Gly Phe Pro Val Val  His Gln Asp 
    2570                 2575                 2580             


Leu Ser  His Ile Gln Gln Pro  Ala Ala Val Val Ala  Ala Leu Ser 
    2585                 2590                 2595             


Ser His  Lys Pro Pro Val Arg  Gly Glu Pro Pro Ala  Ala Ser Pro 
    2600                 2605                 2610             


Glu Ala  Ser Thr Cys Gln Ser  Lys Cys Asp Asp Pro  Glu Glu Glu 
    2615                 2620                 2625             


Leu Cys  His Arg Arg Glu Ala  Arg Ala Phe Ser Glu  Gly Glu Gln 
    2630                 2635                 2640             


Glu Lys  Cys Gly Ser Glu Thr  His His Thr Arg Arg  Asn Ser Arg 
    2645                 2650                 2655             


Trp Asp  Lys Arg Thr Leu Glu  Gln Glu Asp Ser Ser  Ser Lys Lys 
    2660                 2665                 2670             


Arg Lys  Leu Leu 
    2675         


<210>  1238
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1238

Met Asn Ile Met Asp Phe Asn Val Lys Lys Leu Ala Ala Asp Ala Gly 
1               5                   10                  15      


Thr Phe Leu Ser Arg Ala Val Gln Phe Thr Glu Glu Lys Leu Gly Gln 
            20                  25                  30          


Ala Glu Lys Thr Glu Leu Asp Ala His Leu Glu Asn Leu Leu Ser Lys 
        35                  40                  45              


Ala Glu Cys Thr Lys Ile Trp Thr Glu Lys Ile Met Lys Gln Thr Glu 
    50                  55                  60                  


Val Leu Leu Gln Pro Asn Pro Asn Ala Arg Ile Glu Glu Phe Val Tyr 
65                  70                  75                  80  


Glu Lys Leu Asp Arg Lys Ala Pro Ser Arg Ile Asn Asn Pro Glu Leu 
                85                  90                  95      


Leu Gly Gln Tyr Met Ile Asp Ala Gly Thr Glu Phe Gly Pro Gly Thr 
            100                 105                 110         


Ala Tyr Gly Asn Ala Leu Ile Lys Cys Gly Glu Thr Gln Lys Arg Ile 
        115                 120                 125             


Gly Thr Ala Asp Arg Glu Leu Ile Gln Thr Ser Ala Leu Asn Phe Leu 
    130                 135                 140                 


Thr Pro Leu Arg Asn Phe Ile Glu Gly Asp Tyr Lys Thr Ile Ala Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Leu Gln Asn Lys Arg Leu Asp Leu Asp Ala Ala Lys 
                165                 170                 175     


Thr Arg Leu Lys Lys Ala Lys Ala Ala Glu Thr Arg Asn Ser Ser Glu 
            180                 185                 190         


Gln Glu Leu Arg Ile Thr Gln Ser Glu Phe Asp Arg Gln Ala Glu Ile 
        195                 200                 205             


Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr His Ala His His Leu 
    210                 215                 220                 


Arg Cys Leu Asn Asp Phe Val Glu Ala Gln Met Thr Tyr Tyr Ala Gln 
225                 230                 235                 240 


Cys Tyr Gln Tyr Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Phe Pro 
                245                 250                 255     


Ser Asn Tyr Leu Ser Asn Asn Asn Gln Thr Ser Val Thr Pro Val Pro 
            260                 265                 270         


Ser Val Leu Pro Asn Ala Ile Gly Ser Ser Ala Met Ala Ser Thr Ser 
        275                 280                 285             


Gly Leu Val Ile Thr Ser Pro Ser Asn Leu Ser Asp Leu Lys Glu Cys 
    290                 295                 300                 


Ser Gly Ser Arg Lys Ala Arg Val Leu Tyr Asp Tyr Asp Ala Ala Asn 
305                 310                 315                 320 


Ser Thr Glu Leu Ser Leu Leu Ala Asp Glu Val Ile Thr Val Phe Ser 
                325                 330                 335     


Val Val Gly Met Asp Ser Asp Trp Leu Met Gly Glu Arg Gly Asn Gln 
            340                 345                 350         


Lys Gly Lys Val Pro Ile Thr Tyr Leu Glu Leu Leu Asn 
        355                 360                 365 


<210>  1239
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  1239

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  1240
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  1240

Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210>  1241
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  1241

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  1242
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1242

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro 
1               5                   10                  15      


Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr 
            20                  25                  30          


His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser 
    50                  55                  60                  


Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln 
65                  70                  75                  80  


Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu 
                85                  90                  95      


Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser 
            100                 105                 110         


Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln 
        115                 120                 125             


Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu 
    130                 135                 140                 


Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu 
145                 150                 155                 160 


Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe Leu 
                165                 170                 175     


Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp Val 
            180                 185                 190         


Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu Ala 
        195                 200                 205             


Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met Thr 
    210                 215                 220                 


Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly Glu 
225                 230                 235                 240 


Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu Val 
                245                 250                 255     


Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270 


<210>  1243
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1243

Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe 
1               5                   10                  15      


Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu 
            20                  25                  30          


His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val 
        35                  40                  45              


Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg 
    50                  55                  60                  


Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His 
65                  70                  75                  80  


Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu 
                85                  90                  95      


Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu 
            100                 105                 110         


Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 
        115                 120                 125             


His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala 
    130                 135                 140                 


Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly 
145                 150                 155                 160 


Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu 
                165                 170                 175     


Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe 
            180                 185                 190         


Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 
        195                 200                 205             


Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys 
    210                 215                 220                 


Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys 
225                 230                 235                 240 


Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr 
                245                 250                 255     


Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala Asp Lys Gln Glu 
            260                 265                 270         


Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 
        275                 280                 285             


Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu 
    290                 295                 300                 


Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys 
305                 310                 315                 320 


Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 
                325                 330                 335     


Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln 
            340                 345                 350         


Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr 
        355                 360                 365             


Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly 
    370                 375                 380                 


Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu 
385                 390                 395                 400 


Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu 
                405                 410                 415     


Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg 
            420                 425                 430         


Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly 
        435                 440                 445             


Met Ser 
    450 


<210>  1244
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  1244

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210>  1245
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  1245

Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                  15      


Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                  25                  30          


Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                  40                  45              


Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                  55                  60                  


Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                  70                  75                  80  


Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                  90                  95      


Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                 105                 110         


Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                 120                 125             


Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                 135                 140                 


Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                 150                 155                 160 


Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                 170                 175     


Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                 185                 190         


Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                 200                 205             


Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                 215                 220                 


Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                 230                 235                 240 


Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                 250                 255     


Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                 265                 270         


Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                 280                 285             


Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                 295                 300                 


Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                 310                 315                 320 


Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                 330                 335     


Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                 345                 350         


Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                 360                 365             


Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                 375                 380                 


Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
385                 390                 395                 400 


Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
                405                 410                 415     


Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
            420                 425                 430         


<210>  1246
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1246

Met Asp Lys Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe 
1               5                   10                  15      


Arg Gln Ala Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln 
            20                  25                  30          


Lys Thr Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu 
        35                  40                  45              


Ser Leu Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu 
    50                  55                  60                  


Val Asn Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu 
65                  70                  75                  80  


Asp Ser Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp 
                85                  90                  95      


Lys Val Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Val Arg Arg 
            100                 105                 110         


Gln Glu Val Ser Ser Pro Arg Lys Glu Thr Ser Ala Arg Ser Leu Gly 
        115                 120                 125             


Ser Pro Leu Leu His Glu Arg Gly Asn Ile Glu Lys Thr Phe Trp Asp 
    130                 135                 140                 


Leu Lys Glu Glu Phe His Lys Ile Cys Met Leu Ala Lys Ala Gln Lys 
145                 150                 155                 160 


Asp His Leu Ser Lys Leu Asn Ile Pro Asp Thr Ala Thr Glu Thr Gln 
                165                 170                 175     


Cys Ser Val Pro Ile Gln Cys Thr Asp Lys Thr Asp Lys Gln Glu Ala 
            180                 185                 190         


Leu Phe Lys Pro Gln Ala Lys Asp Asp Ile Asn Arg Gly Ala Pro Ser 
        195                 200                 205             


Ile Thr Ser Val Thr Pro Arg Gly Leu Cys Arg Asp Glu Glu Asp Thr 
    210                 215                 220                 


Ser Phe Glu Ser Leu Ser Lys Phe Asn Val Lys Phe Pro Pro Met Asp 
225                 230                 235                 240 


Asn Asp Ser Thr Phe Leu His Ser Thr Pro Glu Arg Pro Gly Ile Leu 
                245                 250                 255     


Ser Pro Ala Thr Ser Glu Ala Val Cys Gln Glu Lys Phe Asn Met Glu 
            260                 265                 270         


Phe Arg Asp Asn Pro Gly Asn Phe Val Lys Thr Glu Glu Thr Leu Phe 
        275                 280                 285             


Glu Ile Gln Gly Ile Asp Pro Ile Ala Ser Ala Ile Gln Asn Leu Lys 
    290                 295                 300                 


Thr Thr Asp Lys Thr Lys Pro Ser Asn Leu Val Asn Thr Cys Ile Arg 
305                 310                 315                 320 


Thr Thr Leu Asp Arg Ala Ala Cys Leu Pro Pro Gly Asp His Asn Ala 
                325                 330                 335     


Leu Tyr Val Asn Ser Phe Pro Leu Leu Asp Pro Ser Asp Ala Pro Phe 
            340                 345                 350         


Pro Ser Leu Asp Ser Pro Gly Lys Ala Ile Arg Gly Pro Gln Gln Pro 
        355                 360                 365             


Ile Trp Lys Pro Phe Pro Asn Gln Asp Ser Asp Ser Val Val Leu Ser 
    370                 375                 380                 


Gly Thr Asp Ser Glu Leu His Ile Pro Arg Val Cys Glu Phe Cys Gln 
385                 390                 395                 400 


Ala Val Phe Pro Pro Ser Ile Thr Ser Arg Gly Asp Phe Leu Arg His 
                405                 410                 415     


Leu Asn Ser His Phe Asn Gly Glu Thr 
            420                 425 


<210>  1247
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  1247

Met Ala Glu Leu Leu Ala Ser Ala Gly Ser Ala Cys Ser Trp Asp Phe 
1               5                   10                  15      


Pro Arg Ala Pro Pro Ser Phe Pro Pro Pro Ala Ala Ser Arg Gly Gly 
            20                  25                  30          


Leu Gly Gly Thr Arg Ser Phe Arg Pro His Arg Gly Ala Glu Ser Pro 
        35                  40                  45              


Arg Pro Gly Arg Asp Arg Asp Gly Val Arg Val Pro Met Ala Ser Ser 
    50                  55                  60                  


Arg Cys Pro Ala Pro Arg Gly Cys Arg Cys Leu Pro Gly Ala Ser Leu 
65                  70                  75                  80  


Ala Trp Leu Gly Thr Val Leu Leu Leu Leu Ala Asp Trp Val Leu Leu 
                85                  90                  95      


Arg Thr Ala Leu Pro Arg Ile Phe Ser Leu Leu Val Pro Thr Ala Leu 
            100                 105                 110         


Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg Trp Ala Val Leu 
        115                 120                 125             


Trp Leu Gly Ala Cys Gly Val Leu Arg Ala Thr Gly Gly Ser Lys Ser 
    130                 135                 140                 


Glu Asn Ala Gly Ala Gln Gly Trp Leu Ala Ala Leu Lys Pro Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Gly Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu 
                165                 170                 175     


Ile Ser Trp Gly Ala Pro Gly Ser Ala Asp Ser Thr Arg Leu Leu His 
            180                 185                 190         


Trp Gly Ser His Pro Thr Ala Phe Val Val Ser Tyr Ala Ala Ala Leu 
        195                 200                 205             


Pro Ala Ala Ala Leu Trp His Lys Leu Gly Ser Leu Trp Val Pro Gly 
    210                 215                 220                 


Gly Gln Gly Gly Ser Gly Asn Pro Val Arg Arg Leu Leu Gly Cys Leu 
225                 230                 235                 240 


Gly Ser Glu Thr Arg Arg Leu Ser Leu Phe Leu Val Leu Val Val Leu 
                245                 250                 255     


Ser Ser Leu Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Leu Thr 
            260                 265                 270         


Asp Trp Ile Leu Gln Asp Gly Ser Ala Asp Thr Phe Thr Arg Asn Leu 
        275                 280                 285             


Thr Leu Met Ser Ile Leu Thr Ile Ala Ser Ala Val Leu Glu Phe Val 
    290                 295                 300                 


Gly Asp Gly Ile Tyr Asn Asn Thr Met Gly His Val His Ser His Leu 
305                 310                 315                 320 


Gln Gly Glu Val Phe Gly Ala Val Leu Arg Gln Glu Thr Glu Phe Phe 
                325                 330                 335     


Gln Gln Asn Gln Thr Gly Asn Ile Met Ser Arg Val Thr Glu Asp Thr 
            340                 345                 350         


Ser Thr Leu Ser Asp Ser Leu Ser Glu Asn Leu Ser Leu Phe Leu Trp 
        355                 360                 365             


Tyr Leu Val Arg Gly Leu Cys Leu Leu Gly Ile Met Leu Trp Gly Ser 
    370                 375                 380                 


Val Ser Leu Thr Met Val Thr Leu Ile Thr Leu Pro Leu Leu Phe Leu 
385                 390                 395                 400 


Leu Pro Lys Lys Val Gly Lys Trp Tyr Gln Leu Leu Glu Val Gln Val 
                405                 410                 415     


Arg Glu Ser Leu Ala Lys Ser Ser Gln Val Ala Ile Glu Ala Leu Ser 
            420                 425                 430         


Ala Met Pro Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln 
        435                 440                 445             


Lys Phe Arg Glu Lys Leu Gln Glu Ile Lys Thr Leu Asn Gln Lys Glu 
    450                 455                 460                 


Ala Val Ala Tyr Ala Val Asn Ser Trp Thr Thr Ser Ile Ser Gly Met 
465                 470                 475                 480 


Leu Leu Lys Val Gly Ile Leu Tyr Ile Gly Gly Gln Leu Val Thr Ser 
                485                 490                 495     


Gly Ala Val Ser Ser Gly Asn Leu Val Thr Phe Val Leu Tyr Gln Met 
            500                 505                 510         


Gln Phe Thr Gln Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Arg Val 
        515                 520                 525             


Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg 
    530                 535                 540                 


Thr Pro Arg Cys Pro Pro Ser Gly Leu Leu Thr Pro Leu His Leu Glu 
545                 550                 555                 560 


Gly Leu Val Gln Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg Pro 
                565                 570                 575     


Asp Val Leu Val Leu Gln Gly Leu Thr Phe Thr Leu Arg Pro Gly Glu 
            580                 585                 590         


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
        595                 600                 605             


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
    610                 615                 620                 


Asp Gly Lys Pro Leu Pro Gln Tyr Glu His Arg Tyr Leu His Arg Gln 
625                 630                 635                 640 


Val Ala Ala Val Gly Gln Glu Pro Gln Val Phe Gly Arg Ser Leu Gln 
                645                 650                 655     


Glu Asn Ile Ala Tyr Gly Leu Thr Gln Lys Pro Thr Met Glu Glu Ile 
            660                 665                 670         


Thr Ala Ala Ala Val Lys Ser Gly Ala His Ser Phe Ile Ser Gly Leu 
        675                 680                 685             


Pro Gln Gly Tyr Asp Thr Glu Val Asp Glu Ala Gly Ser Gln Leu Ser 
    690                 695                 700                 


Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys 
705                 710                 715                 720 


Pro Cys Val Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Asn 
                725                 730                 735     


Ser Gln Leu Gln Val Glu Gln Leu Leu Tyr Glu Ser Pro Glu Arg Tyr 
            740                 745                 750         


Ser Arg Ser Val Leu Leu Ile Thr Gln His Leu Ser Leu Val Glu Gln 
        755                 760                 765             


Ala Asp His Ile Leu Phe Leu Glu Gly Gly Ala Ile Arg Glu Gly Gly 
    770                 775                 780                 


Thr His Gln Gln Leu Met Glu Lys Lys Gly Cys Tyr Trp Ala Met Val 
785                 790                 795                 800 


Gln Ala Pro Ala Asp Ala Pro Glu 
                805             


<210>  1248
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  1248

Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu 
1               5                   10                  15      


Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser 
            20                  25                  30          


Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser 
        35                  40                  45              


Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His 
    50                  55                  60                  


Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met 
65                  70                  75                  80  


Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val 
                85                  90                  95      


Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr 
            100                 105                 110         


Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly 
        115                 120                 125             


Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro 
    130                 135                 140                 


Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro 
145                 150                 155                 160 


Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val 
                165                 170                 175     


Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala 
            180                 185                 190         


Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr 
        195                 200                 205             


Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser 
    210                 215                 220                 


Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly 
225                 230                 235                 240 


Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser 
                245                 250                 255     


Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp 
            260                 265                 270         


Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr 
        275                 280                 285             


Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp 
    290                 295                 300                 


Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr 
305                 310                 315                 320 


Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His 
                325                 330                 335     


Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro 
            340                 345                 350         


Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln 
        355                 360                 365             


Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser 
    370                 375                 380                 


Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu 
385                 390                 395                 400 


Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly 
                405                 410                 415     


Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly 
            420                 425                 430         


Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser 
        435                 440                 445             


Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser 
    450                 455                 460                 


His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln 
465                 470                 475                 480 


Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly 
                485                 490                 495     


Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu 
            500                 505                 510         


Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser 
        515                 520                 525             


Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile 
    530                 535                 540                 


Thr Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln Lys Ala Glu 
545                 550                 555                 560 


Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg 
                565                 570                 575     


Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Val Gln 
            580                 585                 590         


Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu Ile Leu His 
        595                 600                 605             


Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg 
    610                 615                 620                 


Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys 
625                 630                 635                 640 


Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro His Pro Gly 
                645                 650                 655     


Met Gly Asp Ala Ser Asn His Met Gly Gln Met 
            660                 665         


<210>  1249
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  1249

Met Gly Ser Met Phe Arg Ser Glu Glu Val Ala Leu Val Gln Leu Phe 
1               5                   10                  15      


Leu Pro Thr Ala Ala Ala Tyr Thr Cys Val Ser Arg Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Glu Phe Arg Asp Leu Asn Ala Ser Val Ser Ala Phe Gln 
        35                  40                  45              


Arg Arg Phe Val Val Asp Val Arg Arg Cys Glu Glu Leu Glu Lys Thr 
    50                  55                  60                  


Phe Thr Phe Leu Gln Glu Glu Val Arg Arg Ala Gly Leu Val Leu Pro 
65                  70                  75                  80  


Pro Pro Lys Gly Arg Leu Pro Ala Pro Pro Pro Arg Asp Leu Leu Arg 
                85                  90                  95      


Ile Gln Glu Glu Thr Glu Arg Leu Ala Gln Glu Leu Arg Asp Val Arg 
            100                 105                 110         


Gly Asn Gln Gln Ala Leu Arg Ala Gln Leu His Gln Leu Gln Leu His 
        115                 120                 125             


Ala Ala Val Leu Arg Gln Gly His Glu Pro Gln Leu Ala Ala Ala His 
    130                 135                 140                 


Thr Asp Gly Ala Ser Glu Arg Thr Pro Leu Leu Gln Ala Pro Gly Gly 
145                 150                 155                 160 


Pro His Gln Asp Leu Arg Val Asn Phe Val Ala Gly Ala Val Glu Pro 
                165                 170                 175     


His Lys Ala Pro Ala Leu Glu Arg Leu Leu Trp Arg Ala Cys Arg Gly 
            180                 185                 190         


Phe Leu Ile Ala Ser Phe Arg Glu Leu Glu Gln Pro Leu Glu His Pro 
        195                 200                 205             


Val Thr Gly Glu Pro Ala Thr Trp Met Thr Phe Leu Ile Ser Tyr Trp 
    210                 215                 220                 


Gly Glu Gln Ile Gly Gln Lys Ile Arg Lys Ile Thr Asp Cys Phe His 
225                 230                 235                 240 


Cys His Val Phe Pro Phe Leu Gln Gln Glu Glu Ala Arg Leu Gly Ala 
                245                 250                 255     


Leu Gln Gln Leu Gln Gln Gln Ser Gln Glu Leu Gln Glu Val Leu Gly 
            260                 265                 270         


Glu Thr Glu Arg Phe Leu Ser Gln Val Leu Gly Arg Val Leu Gln Leu 
        275                 280                 285             


Leu Pro Pro Gly Gln Val Gln Val His Lys Met Lys Ala Val Tyr Leu 
    290                 295                 300                 


Ala Leu Asn Gln Cys Ser Val Ser Thr Thr His Lys Cys Leu Ile Ala 
305                 310                 315                 320 


Glu Ala Trp Cys Ser Val Arg Asp Leu Pro Ala Leu Gln Glu Ala Leu 
                325                 330                 335     


Arg Asp Ser Ser Met Glu Glu Gly Val Ser Ala Val Ala His Arg Ile 
            340                 345                 350         


Pro Cys Arg Asp Met Pro Pro Thr Leu Ile Arg Thr Asn Arg Phe Thr 
        355                 360                 365             


Ala Ser Phe Gln Gly Ile Val Asp Ala Tyr Gly Val Gly Arg Tyr Gln 
    370                 375                 380                 


Glu Val Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro Phe Leu Phe 
385                 390                 395                 400 


Ala Val Met Phe Gly Asp Val Gly His Gly Leu Leu Met Phe Leu Phe 
                405                 410                 415     


Ala Leu Ala Met Val Leu Ala Glu Asn Arg Pro Ala Val Lys Ala Ala 
            420                 425                 430         


Gln Asn Glu Ile Trp Gln Thr Phe Phe Arg Gly Arg Tyr Leu Leu Leu 
        435                 440                 445             


Leu Met Gly Leu Phe Ser Ile Tyr Thr Gly Phe Ile Tyr Asn Glu Cys 
    450                 455                 460                 


Phe Ser Arg Ala Thr Ser Ile Phe Pro Ser Gly Trp Ser Val Ala Ala 
465                 470                 475                 480 


Met Ala Asn Gln Ser Gly Trp Ser Asp Ala Phe Leu Ala Gln His Thr 
                485                 490                 495     


Met Leu Thr Leu Asp Pro Asn Val Thr Gly Val Phe Leu Gly Pro Tyr 
            500                 505                 510         


Pro Phe Gly Ile Asp Pro Ile Trp Ser Leu Ala Ala Asn His Leu Ser 
        515                 520                 525             


Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Val Val 
    530                 535                 540                 


His Met Ala Phe Gly Val Val Leu Gly Val Phe Asn His Val His Phe 
545                 550                 555                 560 


Gly Gln Arg His Arg Leu Leu Leu Glu Thr Leu Pro Glu Leu Thr Phe 
                565                 570                 575     


Leu Leu Gly Leu Phe Gly Tyr Leu Val Phe Leu Val Ile Tyr Lys Trp 
            580                 585                 590         


Leu Cys Val Trp Ala Ala Arg Ala Ala Ser Ala Pro Ser Ile Leu Ile 
        595                 600                 605             


His Phe Ile Asn Met Phe Leu Phe Ser His Ser Pro Ser Asn Arg Leu 
    610                 615                 620                 


Leu Tyr Pro Arg Gln Glu Val Val Gln Ala Thr Leu Val Val Leu Ala 
625                 630                 635                 640 


Leu Ala Met Val Pro Ile Leu Leu Leu Gly Thr Pro Leu His Leu Leu 
                645                 650                 655     


His Arg His Arg Arg Arg Leu Arg Arg Arg Pro Ala Asp Arg Gln Glu 
            660                 665                 670         


Glu Asn Lys Ala Gly Leu Leu Asp Leu Pro Asp Ala Ser Val Asn Gly 
        675                 680                 685             


Trp Ser Ser Asp Glu Glu Lys Ala Gly Gly Leu Asp Asp Glu Glu Glu 
    690                 695                 700                 


Ala Glu Leu Val Pro Ser Glu Val Leu Met His Gln Ala Ile His Thr 
705                 710                 715                 720 


Ile Glu Phe Cys Leu Gly Cys Val Ser Asn Thr Ala Ser Tyr Leu Arg 
                725                 730                 735     


Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp 
            740                 745                 750         


Ala Met Val Met Arg Ile Gly Leu Gly Leu Gly Arg Glu Val Gly Val 
        755                 760                 765             


Ala Ala Val Val Leu Val Pro Ile Phe Ala Ala Phe Ala Val Met Thr 
    770                 775                 780                 


Val Ala Ile Leu Leu Val Met Glu Gly Leu Ser Ala Phe Leu His Ala 
785                 790                 795                 800 


Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr 
                805                 810                 815     


Gly Tyr Lys Leu Ser Pro Phe Thr Phe Ala Ala Thr Asp Asp 
            820                 825                 830 


<210>  1250
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  1250

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  1251
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1251

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  1252
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1252

Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu Cys Glu Cys Ile 
1               5                   10                  15      


Asp Trp Ser Glu Arg Arg Asn Ala Val Ala Ser Val Val Ala Gly Ile 
            20                  25                  30          


Leu Phe Phe Thr Gly Trp Trp Ile Met Ile Asp Ala Ala Val Val Tyr 
        35                  40                  45              


Pro Lys Pro Glu Gln Leu Asn His Ala Phe His Thr Cys Gly Val Phe 
    50                  55                  60                  


Ser Thr Leu Ala Phe Phe Met Ile Asn Ala Val Ser Asn Ala Gln Val 
65                  70                  75                  80  


Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg Thr Gly Ala Arg 
                85                  90                  95      


Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly Ser Leu Ile Ala 
            100                 105                 110         


Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln Asn Thr Asp Val 
        115                 120                 125             


Tyr Pro Gly Leu Ala Val Phe Phe Gln Asn Ala Leu Ile Phe Phe Ser 
    130                 135                 140                 


Thr Leu Ile Tyr Lys Phe Gly Arg Thr Glu Glu Leu Trp Thr 
145                 150                 155             


<210>  1253
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  1253

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
        595                 600                 605             


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
    610                 615                 620                 


Pro Glu Ser Pro Lys Asn Asp Arg Glu Gly Pro Gln 
625                 630                 635     


<210>  1254
<211>  1621
<212>  PRT
<213>  Homo sapiens

<400>  1254

Met Ala Lys Ser Gly Gly Cys Gly Ala Gly Ala Gly Val Gly Gly Gly 
1               5                   10                  15      


Asn Gly Ala Leu Thr Trp Val Asn Asn Ala Ala Lys Lys Glu Glu Ser 
            20                  25                  30          


Glu Thr Ala Asn Lys Asn Asp Ser Ser Lys Lys Leu Ser Val Glu Arg 
        35                  40                  45              


Val Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 
    50                  55                  60                  


Thr Tyr Ile Gly Ser Val Glu Pro Leu Thr Gln Phe Met Trp Val Tyr 
65                  70                  75                  80  


Asp Glu Asp Val Gly Met Asn Cys Arg Glu Val Thr Phe Val Pro Gly 
                85                  90                  95      


Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 
            100                 105                 110         


Gln Arg Asp Lys Asn Met Thr Cys Ile Lys Val Ser Ile Asp Pro Glu 
        115                 120                 125             


Ser Asn Ile Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 
    130                 135                 140                 


Glu His Lys Val Glu Lys Val Tyr Val Pro Ala Leu Ile Phe Gly Gln 
145                 150                 155                 160 


Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 
                165                 170                 175     


Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 
            180                 185                 190         


Phe Thr Val Glu Thr Ala Cys Lys Glu Tyr Lys His Ser Phe Lys Gln 
        195                 200                 205             


Thr Trp Met Asn Asn Met Met Lys Thr Ser Glu Ala Lys Ile Lys His 
    210                 215                 220                 


Phe Asp Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 
225                 230                 235                 240 


Lys Phe Lys Met Glu Lys Leu Asp Lys Asp Ile Val Ala Leu Met Thr 
                245                 250                 255     


Arg Arg Ala Tyr Asp Leu Ala Gly Ser Cys Arg Gly Val Lys Val Met 
            260                 265                 270         


Phe Asn Gly Lys Lys Leu Pro Val Asn Gly Phe Arg Ser Tyr Val Asp 
        275                 280                 285             


Leu Tyr Val Lys Asp Lys Leu Asp Glu Thr Gly Val Ala Leu Lys Val 
    290                 295                 300                 


Ile His Glu Leu Ala Asn Glu Arg Trp Asp Val Cys Leu Thr Leu Ser 
305                 310                 315                 320 


Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Thr 
                325                 330                 335     


Lys Gly Gly Arg His Val Asp Tyr Val Val Asp Gln Val Val Gly Lys 
            340                 345                 350         


Leu Ile Glu Val Val Lys Lys Lys Asn Lys Ala Gly Val Ser Val Lys 
        355                 360                 365             


Pro Phe Gln Val Lys Asn His Ile Trp Val Phe Ile Asn Cys Leu Ile 
    370                 375                 380                 


Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 
385                 390                 395                 400 


Pro Lys Ser Phe Gly Ser Lys Cys Gln Leu Ser Glu Lys Phe Phe Lys 
                405                 410                 415     


Ala Ala Ser Asn Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 
            420                 425                 430         


Phe Lys Ala Gln Thr Gln Leu Asn Lys Lys Cys Ser Ser Val Lys Tyr 
        435                 440                 445             


Ser Lys Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 
    450                 455                 460                 


Gly Lys His Ser Leu Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 
465                 470                 475                 480 


Ala Lys Ser Leu Ala Val Ser Gly Leu Gly Val Ile Gly Arg Asp Arg 
                485                 490                 495     


Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 
            500                 505                 510         


Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 
        515                 520                 525             


Ile Val Gly Leu Gln Tyr Lys Lys Ser Tyr Asp Asp Ala Glu Ser Leu 
    530                 535                 540                 


Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 
545                 550                 555                 560 


Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 
                565                 570                 575     


Trp Pro Ser Leu Leu Lys His Gly Phe Leu Glu Glu Phe Ile Thr Pro 
            580                 585                 590         


Ile Val Lys Ala Ser Lys Asn Lys Gln Glu Leu Ser Phe Tyr Ser Ile 
        595                 600                 605             


Pro Glu Phe Asp Glu Trp Lys Lys His Ile Glu Asn Gln Lys Ala Trp 
    610                 615                 620                 


Lys Ile Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ala Lys Glu Ala 
625                 630                 635                 640 


Lys Glu Tyr Phe Ala Asp Met Glu Arg His Arg Ile Leu Phe Arg Tyr 
                645                 650                 655     


Ala Gly Pro Glu Asp Asp Ala Ala Ile Thr Leu Ala Phe Ser Lys Lys 
            660                 665                 670         


Lys Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 
        675                 680                 685             


Arg Gln Arg Arg Leu His Gly Leu Pro Glu Gln Phe Leu Tyr Gly Thr 
    690                 695                 700                 


Ala Thr Lys His Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 
705                 710                 715                 720 


Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Leu Val Asp 
                725                 730                 735     


Gly Phe Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 
            740                 745                 750         


Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 
        755                 760                 765             


Glu Met Ser Ala Tyr His His Gly Glu Gln Ala Leu Met Met Thr Ile 
    770                 775                 780                 


Val Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Ile Asn Leu Leu 
785                 790                 795                 800 


Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ala 
                805                 810                 815     


Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Thr Leu Ala Arg Leu 
            820                 825                 830         


Leu Phe Pro Ala Val Asp Asp Asn Leu Leu Lys Phe Leu Tyr Asp Asp 
        835                 840                 845             


Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 
    850                 855                 860                 


Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ala Cys Lys Leu 
865                 870                 875                 880 


Pro Asn Tyr Asp Ala Arg Glu Ile Val Asn Asn Val Arg Arg Met Leu 
                885                 890                 895     


Asp Gly Leu Asp Pro His Pro Met Leu Pro Asn Tyr Lys Asn Phe Lys 
            900                 905                 910         


Gly Thr Ile Gln Glu Leu Gly Gln Asn Gln Tyr Ala Val Ser Gly Glu 
        915                 920                 925             


Ile Phe Val Val Asp Arg Asn Thr Val Glu Ile Thr Glu Leu Pro Val 
    930                 935                 940                 


Arg Thr Trp Thr Gln Val Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 
945                 950                 955                 960 


Asn Gly Thr Asp Lys Thr Pro Ala Leu Ile Ser Asp Tyr Lys Glu Tyr 
                965                 970                 975     


His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 
            980                 985                 990         


Leu Ala Gln Ala Glu Ala Ala Gly  Leu His Lys Val Phe  Lys Leu Gln 
        995                 1000                 1005             


Thr Thr  Leu Thr Cys Asn Ser  Met Val Leu Phe Asp  His Met Gly 
    1010                 1015                 1020             


Cys Leu  Lys Lys Tyr Glu Thr  Val Gln Asp Ile Leu  Lys Glu Phe 
    1025                 1030                 1035             


Phe Asp  Leu Arg Leu Ser Tyr  Tyr Gly Leu Arg Lys  Glu Trp Leu 
    1040                 1045                 1050             


Val Gly  Met Leu Gly Ala Glu  Ser Thr Lys Leu Asn  Asn Gln Ala 
    1055                 1060                 1065             


Arg Phe  Ile Leu Glu Lys Ile  Gln Gly Lys Ile Thr  Ile Glu Asn 
    1070                 1075                 1080             


Arg Ser  Lys Lys Asp Leu Ile  Gln Met Leu Val Gln  Arg Gly Tyr 
    1085                 1090                 1095             


Glu Ser  Asp Pro Val Lys Ala  Trp Lys Glu Ala Gln  Glu Lys Ala 
    1100                 1105                 1110             


Ala Glu  Glu Asp Glu Thr Gln  Asn Gln His Asp Asp  Ser Ser Ser 
    1115                 1120                 1125             


Asp Ser  Gly Thr Pro Ser Gly  Pro Asp Phe Asn Tyr  Ile Leu Asn 
    1130                 1135                 1140             


Met Ser  Leu Trp Ser Leu Thr  Lys Glu Lys Val Glu  Glu Leu Ile 
    1145                 1150                 1155             


Lys Gln  Arg Asp Ala Lys Gly  Arg Glu Val Asn Asp  Leu Lys Arg 
    1160                 1165                 1170             


Lys Ser  Pro Ser Asp Leu Trp  Lys Glu Asp Leu Ala  Ala Phe Val 
    1175                 1180                 1185             


Glu Glu  Leu Asp Lys Val Glu  Ser Gln Glu Arg Glu  Asp Val Leu 
    1190                 1195                 1200             


Ala Gly  Met Ser Gly Lys Ala  Ile Lys Gly Lys Val  Gly Lys Pro 
    1205                 1210                 1215             


Lys Val  Lys Lys Leu Gln Leu  Glu Glu Thr Met Pro  Ser Pro Tyr 
    1220                 1225                 1230             


Gly Arg  Arg Ile Ile Pro Glu  Ile Thr Ala Met Lys  Ala Asp Ala 
    1235                 1240                 1245             


Ser Lys  Lys Leu Leu Lys Lys  Lys Lys Gly Asp Leu  Asp Thr Ala 
    1250                 1255                 1260             


Ala Val  Lys Val Glu Phe Asp  Glu Glu Phe Ser Gly  Ala Pro Val 
    1265                 1270                 1275             


Glu Gly  Ala Gly Glu Glu Ala  Leu Thr Pro Ser Val  Pro Ile Asn 
    1280                 1285                 1290             


Lys Gly  Pro Lys Pro Lys Arg  Glu Lys Lys Glu Pro  Gly Thr Arg 
    1295                 1300                 1305             


Val Arg  Lys Thr Pro Thr Ser  Ser Gly Lys Pro Ser  Ala Lys Lys 
    1310                 1315                 1320             


Val Lys  Lys Arg Asn Pro Trp  Ser Asp Asp Glu Ser  Lys Ser Glu 
    1325                 1330                 1335             


Ser Asp  Leu Glu Glu Thr Glu  Pro Val Val Ile Pro  Arg Asp Ser 
    1340                 1345                 1350             


Leu Leu  Arg Arg Ala Ala Ala  Glu Arg Pro Lys Tyr  Thr Phe Asp 
    1355                 1360                 1365             


Phe Ser  Glu Glu Glu Asp Asp  Asp Ala Asp Asp Asp  Asp Asp Asp 
    1370                 1375                 1380             


Asn Asn  Asp Leu Glu Glu Leu  Lys Val Lys Ala Ser  Pro Ile Thr 
    1385                 1390                 1395             


Asn Asp  Gly Glu Asp Glu Phe  Val Pro Ser Asp Gly  Leu Asp Lys 
    1400                 1405                 1410             


Asp Glu  Tyr Thr Phe Ser Pro  Gly Lys Ser Lys Ala  Thr Pro Glu 
    1415                 1420                 1425             


Lys Ser  Leu His Asp Lys Lys  Ser Gln Asp Phe Gly  Asn Leu Phe 
    1430                 1435                 1440             


Ser Phe  Pro Ser Tyr Ser Gln  Lys Ser Glu Asp Asp  Ser Ala Lys 
    1445                 1450                 1455             


Phe Asp  Ser Asn Glu Glu Asp  Ser Ala Ser Val Phe  Ser Pro Ser 
    1460                 1465                 1470             


Phe Gly  Leu Lys Gln Thr Asp  Lys Val Pro Ser Lys  Thr Val Ala 
    1475                 1480                 1485             


Ala Lys  Lys Gly Lys Pro Ser  Ser Asp Thr Val Pro  Lys Pro Lys 
    1490                 1495                 1500             


Arg Ala  Pro Lys Gln Lys Lys  Val Val Glu Ala Val  Asn Ser Asp 
    1505                 1510                 1515             


Ser Asp  Ser Glu Phe Gly Ile  Pro Lys Lys Thr Thr  Thr Pro Lys 
    1520                 1525                 1530             


Gly Lys  Gly Arg Gly Ala Lys  Lys Arg Lys Ala Ser  Gly Ser Glu 
    1535                 1540                 1545             


Asn Glu  Gly Asp Tyr Asn Pro  Gly Arg Lys Thr Ser  Lys Thr Thr 
    1550                 1555                 1560             


Ser Lys  Lys Pro Lys Lys Thr  Ser Phe Asp Gln Asp  Ser Asp Val 
    1565                 1570                 1575             


Asp Ile  Phe Pro Ser Asp Phe  Pro Thr Glu Pro Pro  Ser Leu Pro 
    1580                 1585                 1590             


Arg Thr  Gly Arg Ala Arg Lys  Glu Val Lys Tyr Phe  Ala Glu Ser 
    1595                 1600                 1605             


Asp Glu  Glu Glu Asp Asp Val  Asp Phe Ala Met Phe  Asn 
    1610                 1615                 1620     


<210>  1255
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  1255

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  1256
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  1256

Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Trp Ala 
1               5                   10                  15      


Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser 
            20                  25                  30          


Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys Thr 
        35                  40                  45              


Leu Arg Ile Gln Gln Arg Glu Gln Leu Gln Arg Ala Arg Leu Gln Gln 
    50                  55                  60                  


Phe Phe Arg Arg Arg Asn Leu Glu Leu Glu Glu Lys Gly Lys Ala Gln 
65                  70                  75                  80  


His Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln Val 
                85                  90                  95      


Thr Val Leu Lys Glu Pro Leu Ser Cys Ala Arg Arg Ile Ser Ser Pro 
            100                 105                 110         


Arg Glu Gln Val Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His 
        115                 120                 125             


Pro Pro Pro Ser Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser 
    130                 135                 140                 


Gln Ala Gly Gly Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro 
145                 150                 155                 160 


Lys His His Arg Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys 
                165                 170                 175     


Asn Asp Ala Ser Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys 
            180                 185                 190         


Glu Ile Ile Gln Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu 
        195                 200                 205             


Leu Val Leu Lys Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr 
    210                 215                 220                 


Leu Ile Gln Ala Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp 
225                 230                 235                 240 


Lys Leu Lys Gly Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys 
                245                 250                 255     


Thr Gln Lys Tyr Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met 
            260                 265                 270         


Glu Asp Gln Lys Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr 
    290                 295                 300                 


Gln Arg Ser Leu Ala Leu Ala Glu Gln Lys Cys Glu Glu Trp Arg Ser 
305                 310                 315                 320 


Gln Tyr Glu Ala Leu Lys Glu Asp Trp Arg Thr Leu Gly Thr Gln His 
                325                 330                 335     


Arg Glu Leu Glu Ser Gln Leu His Val Leu Gln Ser Lys Leu Gln Gly 
            340                 345                 350         


Ala Asp Ser Arg Asp Leu Gln Met Asn Gln Ala Leu Arg Phe Leu Glu 
        355                 360                 365             


Asn Glu His Gln Gln Leu Gln Ala Lys Ile Glu Cys Leu Gln Gly Asp 
    370                 375                 380                 


Arg Asp Leu Cys Ser Leu Asp Thr Gln Asp Leu Gln Asp Gln Leu Lys 
385                 390                 395                 400 


Arg Ser Glu Ala Glu Lys Leu Thr Leu Val Thr Arg Val Gln Gln Leu 
                405                 410                 415     


Gln Gly Leu Leu Gln Asn Gln Ser Leu Gln Leu Gln Glu Gln Glu Lys 
            420                 425                 430         


Leu Leu Thr Lys Lys Asp Gln Ala Leu Pro Val Trp Ser Pro Lys Ser 
        435                 440                 445             


Phe Pro Asn Glu Val Glu Pro Glu Gly Thr Gly Lys Glu Lys Asp Trp 
    450                 455                 460                 


Asp Leu Arg Asp Gln Leu Gln Lys Lys Thr Leu Gln Leu Gln Ala Lys 
465                 470                 475                 480 


Glu Lys Glu Cys Arg Glu Leu His Ser Glu Leu Asp Asn Leu Ser Asp 
                485                 490                 495     


Glu Tyr Leu Ser Cys Leu Arg Lys Leu Gln His Cys Arg Glu Glu Leu 
            500                 505                 510         


Asn Gln Ser Gln Gln Leu Pro Pro Arg Arg Gln Cys Gly Arg Trp Leu 
        515                 520                 525             


Pro Val Leu Met Val Val Ile Ala Ala Ala Leu Ala Val Phe Leu Ala 
    530                 535                 540                 


Asn Lys Asp Asn Leu Met Ile 
545                 550     


<210>  1257
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  1257

Met Arg Val Gly Pro Val Arg Ser Ala Met Ser Gly Ala Ser Gln Pro 
1               5                   10                  15      


Arg Gly Pro Ala Leu Leu Phe Pro Ala Thr Arg Gly Val Pro Ala Lys 
            20                  25                  30          


Arg Leu Leu Asp Ala Asp Asp Ala Ala Ala Val Ala Ala Lys Cys Pro 
        35                  40                  45              


Arg Leu Ser Glu Cys Ser Ser Pro Pro Asp Tyr Leu Ser Pro Pro Gly 
    50                  55                  60                  


Ser Pro Cys Ser Pro Gln Pro Pro Pro Ala Ala Pro Gly Ala Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Ser Ala Pro Gly Pro Ser Arg Ile Ala Asp Tyr Leu Leu 
                85                  90                  95      


Leu Pro Leu Ala Glu Arg Glu His Val Ser Arg Ala Leu Cys Ile His 
            100                 105                 110         


Thr Gly Arg Glu Leu Arg Cys Lys Val Phe Pro Ile Lys His Tyr Gln 
        115                 120                 125             


Asp Lys Ile Arg Pro Tyr Ile Gln Leu Pro Ser His Ser Asn Ile Thr 
    130                 135                 140                 


Gly Ile Val Glu Val Ile Leu Gly Glu Thr Lys Ala Tyr Val Phe Phe 
145                 150                 155                 160 


Glu Lys Asp Phe Gly Asp Met His Ser Tyr Val Arg Ser Arg Lys Arg 
                165                 170                 175     


Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Lys Gln Ile Val Ser Ala 
            180                 185                 190         


Val Ala His Cys His Gln Ser Ala Ile Val Leu Gly Asp Leu Lys Leu 
        195                 200                 205             


Arg Lys Phe Val Phe Ser Thr Glu Glu Arg Thr Gln Leu Arg Leu Glu 
    210                 215                 220                 


Ser Leu Glu Asp Thr His Ile Met Lys Gly Glu Asp Asp Ala Leu Ser 
225                 230                 235                 240 


Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu Asn Thr 
                245                 250                 255     


Thr Gly Thr Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu Gly Val 
            260                 265                 270         


Met Leu Tyr Thr Leu Leu Val Gly Arg Tyr Pro Phe His Asp Ser Asp 
        275                 280                 285             


Pro Ser Ala Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Cys Ile Pro 
    290                 295                 300                 


Glu His Ile Ser Pro Lys Ala Arg Cys Leu Ile Arg Ser Leu Leu Arg 
305                 310                 315                 320 


Arg Glu Pro Ser Glu Arg Leu Thr Ala Pro Glu Ile Leu Leu His Pro 
                325                 330                 335     


Trp Phe Glu Ser Val Leu Glu Pro Gly Tyr Ile Asp Ser Glu Ile Gly 
            340                 345                 350         


Thr Ser Asp Gln Ile Val Pro Glu Tyr Gln Glu Asp Ser Asp Ile Ser 
        355                 360                 365             


Ser Phe Phe Cys 
    370         


<210>  1258
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1258

Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu Gly 
        35                  40                  45              


Gly Glu Ile Val Ser Ala Asp Ser Met Gln Val Tyr Glu Gly Leu Asp 
    50                  55                  60                  


Ile Ile Thr Asn Lys Val Ser Ala Gln Glu Gln Arg Ile Cys Arg His 
65                  70                  75                  80  


His Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val 
                85                  90                  95      


Asp Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg 
            100                 105                 110         


Asp Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser 
        115                 120                 125             


Leu Leu Trp Lys Val Leu Val Asn Thr Lys Pro Gln Glu Met Gly Thr 
    130                 135                 140                 


Glu Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu 
145                 150                 155                 160 


Val Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys 
                165                 170                 175     


Leu His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe 
            180                 185                 190         


Glu Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr 
        195                 200                 205             


Glu Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro 
    210                 215                 220                 


Cys Ile Leu Trp Leu His Ala Asp Gln Ala Val Leu Asp Glu Arg Leu 
225                 230                 235                 240 


Asp Lys Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu 
                245                 250                 255     


Arg Asp Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser 
            260                 265                 270         


Gln Asp Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe 
        275                 280                 285             


His Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn 
    290                 295                 300                 


Gln Leu Leu Lys Lys Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg 
305                 310                 315                 320 


Tyr Ala Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg 
                325                 330                 335     


Pro Gly Pro Ile Val Pro Pro Val Tyr Gly Leu Glu Val Ser Asp Val 
            340                 345                 350         


Ser Lys Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln 
        355                 360                 365             


Ser Phe Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro 
    370                 375                 380                 


Tyr Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys 
385                 390                 395                 400 


Asp Arg Ile Ile Ile Gly Asp Arg Glu Trp Ala Ala His Ile Lys Ser 
                405                 410                 415     


Lys Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp 
            420                 425                 430         


Ala Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys 
        435                 440                 445             


Glu Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys 
    450                 455                 460                 


Cys Ser Val 
465         


<210>  1259
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  1259

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile 
1               5                   10                  15      


Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg 
            20                  25                  30          


Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile 
        35                  40                  45              


Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu 
    50                  55                  60                  


Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe 
65                  70                  75                  80  


Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu 
                85                  90                  95      


Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe 
            100                 105                 110         


Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe 
        115                 120                 125             


Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp 
    130                 135                 140                 


Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly 
145                 150                 155                 160 


Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly 
                165                 170                 175     


Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser 
            180                 185                 190         


Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu 
        195                 200                 205             


Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys 
    210                 215                 220                 


Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Arg Asp 
225                 230                 235                 240 


Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu 
                245                 250                 255     


His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu 
            260                 265                 270         


Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met 
        275                 280                 285             


Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val 
    290                 295                 300                 


Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His 
305                 310                 315                 320 


Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly 
                325                 330                 335     


Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala 
            340                 345                 350         


Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly 
        355                 360                 365             


Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg 
    370                 375                 380                 


Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys 
385                 390                 395                 400 


Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser 
                405                 410                 415     


Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln 
            420                 425                 430         


Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser 
        435                 440                 445             


Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe 
    450                 455                 460                 


Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala 
465                 470                 475                 480 


Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu 
                485                 490                 495     


Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp 
            500                 505                 510         


Asp Arg Gly Met Leu Asp Met Cys Gly Phe Asp Thr Gly Ala Leu Asp 
        515                 520                 525             


Val Ile Arg Asn Phe Thr Leu Asp Met Ile 
    530                 535             


<210>  1260
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  1260

Met Ala Ala Ala Pro Val Ala Ala Gly Ser Gly Ala Gly Arg Gly Arg 
1               5                   10                  15      


Arg Ser Ala Ala Thr Val Ala Ala Trp Gly Gly Trp Gly Gly Arg Pro 
            20                  25                  30          


Arg Pro Gly Asn Ile Leu Leu Gln Leu Arg Gln Gly Gln Leu Thr Gly 
        35                  40                  45              


Arg Gly Leu Val Arg Ala Val Gln Phe Thr Glu Thr Phe Leu Thr Glu 
    50                  55                  60                  


Arg Asp Lys Gln Ser Lys Trp Ser Gly Ile Pro Gln Leu Leu Leu Lys 
65                  70                  75                  80  


Leu His Thr Thr Ser His Leu His Ser Asp Phe Val Glu Cys Gln Asn 
                85                  90                  95      


Ile Leu Lys Glu Ile Ser Pro Leu Leu Ser Met Glu Ala Met Ala Phe 
            100                 105                 110         


Val Thr Glu Glu Arg Lys Leu Thr Gln Glu Thr Thr Tyr Pro Asn Thr 
        115                 120                 125             


Tyr Ile Phe Asp Leu Phe Gly Gly Val Asp Leu Leu Val Glu Ile Leu 
    130                 135                 140                 


Met Arg Pro Thr Ile Ser Ile Arg Gly Gln Lys Leu Lys Ile Ser Asp 
145                 150                 155                 160 


Glu Met Ser Lys Asp Cys Leu Ser Ile Leu Tyr Asn Thr Cys Val Cys 
                165                 170                 175     


Thr Glu Gly Val Thr Lys Arg Leu Ala Glu Lys Asn Asp Phe Val Ile 
            180                 185                 190         


Phe Leu Phe Thr Leu Met Thr Ser Lys Lys Thr Phe Leu Gln Thr Ala 
        195                 200                 205             


Thr Leu Ile Glu Asp Ile Leu Gly Val Lys Lys Glu Met Ile Arg Leu 
    210                 215                 220                 


Asp Glu Val Pro Asn Leu Ser Ser Leu Val Ser Asn Phe Asp Gln Gln 
225                 230                 235                 240 


Gln Leu Ala Asn Phe Cys Arg Ile Leu Ala Val Thr Ile Ser Glu Met 
                245                 250                 255     


Asp Thr Gly Asn Asp Asp Lys His Thr Leu Leu Ala Lys Asn Ala Gln 
            260                 265                 270         


Gln Lys Lys Ser Leu Ser Leu Gly Pro Ser Ala Ala Glu Ile Asn Gln 
        275                 280                 285             


Ala Ala Leu Leu Ser Ile Pro Gly Phe Val Glu Arg Leu Cys Lys Leu 
    290                 295                 300                 


Ala Thr Arg Lys Val Ser Glu Ser Thr Gly Thr Ala Ser Phe Leu Gln 
305                 310                 315                 320 


Glu Leu Glu Glu Trp Tyr Thr Trp Leu Asp Asn Ala Leu Val Leu Asp 
                325                 330                 335     


Ala Leu Met Arg Val Ala Asn Glu Glu Ser Glu His Asn Gln Ala Ser 
            340                 345                 350         


Ile Val Phe Pro Pro Pro Gly Ala Ser Glu Glu Asn Gly Leu Pro His 
        355                 360                 365             


Thr Ser Ala Arg Thr Gln Leu Pro Gln Ser Met Lys Ile Met His Glu 
    370                 375                 380                 


Ile Met Tyr Lys Leu Glu Val Leu Tyr Val Leu Cys Val Leu Leu Met 
385                 390                 395                 400 


Gly Arg Gln Arg Asn Gln Val His Arg Met Ile Ala Glu Phe Lys Leu 
                405                 410                 415     


Ile Pro Gly Leu Asn Asn Leu Phe Asp Lys Leu Ile Trp Arg Lys His 
            420                 425                 430         


Ser Ala Ser Ala Leu Val Leu His Gly His Asn Gln Asn Cys Asp Cys 
        435                 440                 445             


Ser Pro Asp Ile Thr Leu Lys Ile Gln Phe Leu Arg Leu Leu Gln Ser 
    450                 455                 460                 


Phe Ser Asp His His Glu Asn Lys Tyr Leu Leu Leu Asn Asn Gln Glu 
465                 470                 475                 480 


Leu Asn Glu Leu Ser Ala Ile Ser Leu Lys Ala Asn Ile Pro Glu Val 
                485                 490                 495     


Glu Ala Val Leu Asn Thr Asp Arg Ser Leu Val Cys Asp Gly Lys Arg 
            500                 505                 510         


Gly Leu Leu Thr Arg Leu Leu Gln Val Met Lys Lys Glu Pro Ala Glu 
        515                 520                 525             


Ser Ser Phe Arg Phe Trp Gln Ala Arg Ala Val Glu Ser Phe Leu Arg 
    530                 535                 540                 


Gly Thr Thr Ser Tyr Ala Asp Gln Met Phe Leu Leu Lys Arg Gly Leu 
545                 550                 555                 560 


Leu Glu His Ile Leu Tyr Cys Ile Val Asp Ser Glu Cys Lys Ser Arg 
                565                 570                 575     


Asp Val Leu Gln Ser Tyr Phe Asp Leu Leu Gly Glu Leu Met Lys Phe 
            580                 585                 590         


Asn Val Asp Ala Phe Lys Arg Phe Asn Lys Tyr Ile Asn Thr Asp Ala 
        595                 600                 605             


Lys Phe Gln Val Phe Leu Lys Gln Ile Asn Ser Ser Leu Val Asp Ser 
    610                 615                 620                 


Asn Met Leu Val Arg Cys Val Thr Leu Ser Leu Asp Arg Phe Glu Asn 
625                 630                 635                 640 


Gln Val Asp Met Lys Val Ala Glu Val Leu Ser Glu Cys Arg Leu Leu 
                645                 650                 655     


Ala Tyr Ile Ser Gln Val Pro Thr Gln Met Ser Phe Leu Phe Arg Leu 
            660                 665                 670         


Ile Asn Ile Ile His Val Gln Thr Leu Thr Gln Glu Asn Val Ser Cys 
        675                 680                 685             


Leu Asn Thr Ser Leu Val Ile Leu Met Leu Ala Arg Arg Lys Glu Arg 
    690                 695                 700                 


Leu Pro Leu Tyr Leu Arg Leu Leu Gln Arg Met Glu His Ser Lys Lys 
705                 710                 715                 720 


Tyr Pro Gly Phe Leu Leu Asn Asn Phe His Asn Leu Leu Arg Phe Trp 
                725                 730                 735     


Gln Gln His Tyr Leu His Lys Asp Lys Asp Ser Thr Cys Leu Glu Asn 
            740                 745                 750         


Ser Ser Cys Ile Ser Phe Ser Tyr Trp Lys Glu Thr Val Ser Ile Leu 
        755                 760                 765             


Leu Asn Pro Asp Arg Gln Ser Pro Ser Ala Leu Val Ser Tyr Ile Glu 
    770                 775                 780                 


Glu Pro Tyr Met Asp Ile Asp Arg Asp Phe Thr Glu Glu 
785                 790                 795         


<210>  1261
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1261

Met Ala Pro Pro Trp Val Pro Ala Met Gly Phe Thr Leu Ala Pro Ser 
1               5                   10                  15      


Leu Gly Cys Phe Val Gly Ser Arg Phe Val His Gly Glu Gly Leu Arg 
            20                  25                  30          


Trp Tyr Ala Gly Leu Gln Lys Pro Ser Trp His Pro Pro His Trp Val 
        35                  40                  45              


Leu Gly Pro Val Trp Gly Thr Leu Tyr Ser Ala Met Gly Tyr Gly Ser 
    50                  55                  60                  


Tyr Leu Val Trp Lys Glu Leu Gly Gly Phe Thr Glu Lys Ala Val Val 
65                  70                  75                  80  


Pro Leu Gly Leu Tyr Thr Gly Gln Leu Ala Leu Asn Trp Ala Trp Pro 
                85                  90                  95      


Pro Ile Phe Phe Gly Ala Arg Gln Met Gly Trp Ala Leu Val Asp Leu 
            100                 105                 110         


Leu Leu Val Ser Gly Ala Ala Ala Ala Thr Thr Val Ala Trp Tyr Gln 
        115                 120                 125             


Val Ser Pro Leu Ala Ala Arg Leu Leu Tyr Pro Tyr Leu Ala Trp Leu 
    130                 135                 140                 


Ala Phe Thr Thr Thr Leu Asn Tyr Cys Val Trp Arg Asp Asn His Gly 
145                 150                 155                 160 


Trp Arg Gly Gly Arg Arg Leu Pro Glu 
                165                 


<210>  1262
<211>  1141
<212>  PRT
<213>  Homo sapiens

<400>  1262

Met Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys 
1               5                   10                  15      


Ser Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala 
            20                  25                  30          


Ala Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly 
        35                  40                  45              


Lys Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His 
    50                  55                  60                  


Asp Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn 
                85                  90                  95      


Glu Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro 
            100                 105                 110         


Asp Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp 
        115                 120                 125             


Gly Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr 
    130                 135                 140                 


Ile Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys 
145                 150                 155                 160 


Thr Lys Ile Leu Glu Leu Pro Tyr Ser Ile His Ala Phe Gln His Leu 
                165                 170                 175     


Arg Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys 
            180                 185                 190         


Glu Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile 
        195                 200                 205             


Asp Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser 
    210                 215                 220                 


Ser Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn 
225                 230                 235                 240 


Glu Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser 
                245                 250                 255     


Ser Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu 
            260                 265                 270         


His Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala 
        275                 280                 285             


Leu Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile 
    290                 295                 300                 


Tyr Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His 
305                 310                 315                 320 


Ala Leu Gln Ala Arg Pro Gly Phe Glu Gln Ala Ile Lys Arg Lys His 
                325                 330                 335     


Ala Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His 
            340                 345                 350         


Arg Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln 
        355                 360                 365             


His Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu 
    370                 375                 380                 


Ile Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met 
385                 390                 395                 400 


Ala Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn 
                405                 410                 415     


Gln Gln His Ser Leu His Cys Gln Trp Asp Gln Pro Val Arg Tyr His 
            420                 425                 430         


Arg Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp 
        435                 440                 445             


Ser Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn 
    450                 455                 460                 


Gln Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser 
465                 470                 475                 480 


Ile Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln 
                485                 490                 495     


His Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg 
            500                 505                 510         


Val Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn 
        515                 520                 525             


Lys Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu 
    530                 535                 540                 


Glu Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser 
545                 550                 555                 560 


His Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu 
                565                 570                 575     


Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg 
            580                 585                 590         


Ile Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe 
        595                 600                 605             


His Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu 
    610                 615                 620                 


Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala 
625                 630                 635                 640 


Cys Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val 
                645                 650                 655     


Pro Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu 
            660                 665                 670         


Asp Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu 
        675                 680                 685             


Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn 
    690                 695                 700                 


Ile Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr 
705                 710                 715                 720 


Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln 
                725                 730                 735     


Phe Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Thr 
            740                 745                 750         


Val Val Glu Glu Ser Asn Gly Ser Asp Glu Met Glu Asn Ser Asp Glu 
        755                 760                 765             


Thr Lys Met Ser Glu Glu Ile Leu Ala Leu Val Asp Glu Phe Gln Gln 
    770                 775                 780                 


Ala Trp Pro Leu Glu Gly Phe Gly Gly Ala Leu Glu Met Lys Gly Arg 
785                 790                 795                 800 


Arg Leu Asp Leu Gln Gly Ile Arg Val Leu Lys Lys Gly Pro Gln Asp 
                805                 810                 815     


Gly Val Ala Arg Ser Ser Cys Tyr Gly Asp Cys Arg Ser Glu Asp Asp 
            820                 825                 830         


Glu Ala Thr Glu Trp Ile Thr Phe Gln Val Lys Arg Val Lys Lys Pro 
        835                 840                 845             


Lys Gly Asp His Lys Lys Thr Pro Gly Lys Lys Val Glu Thr Gly Gln 
    850                 855                 860                 


Ile Glu Asn Gly His Arg Tyr Gln Ala Asn Leu Glu Ile Thr Gly Pro 
865                 870                 875                 880 


Lys Val Ala Ser Pro Gly Pro Gln Gly Lys Lys Arg Asp Tyr Gln Arg 
                885                 890                 895     


Leu Gly Trp Pro Ser Pro Asp Glu Cys Leu Lys Leu Arg Trp Val Glu 
            900                 905                 910         


Leu Thr Ala Ile Val Ser Thr Trp Leu Ala Val Ser Ser Lys Asn Ile 
        915                 920                 925             


Asp Ile Thr Glu His Ile Asp Phe Ala Thr Pro Ile Gln Gln Pro Ala 
    930                 935                 940                 


Met Glu Pro Leu Cys Asn Gly Asn Leu Pro Thr Ser Met His Thr Leu 
945                 950                 955                 960 


Asp His Leu His Gly Val Ser Asn Arg Ala Ser Leu His Tyr Thr Gly 
                965                 970                 975     


Glu Ser Gln Leu Thr Glu Val Leu Gln Asn Leu Gly Lys Asp Gln Tyr 
            980                 985                 990         


Pro Gln Gln Ser Leu Glu Gln Ile  Gly Thr Arg Ile Ala  Lys Val Leu 
        995                 1000                 1005             


Glu Lys  Asn Gln Thr Ser Trp  Val Leu Ser Ser Met  Ala Ala Leu 
    1010                 1015                 1020             


Tyr Trp  Arg Val Lys Gly Gln  Gly Lys Lys Ala Ile  Asp Cys Leu 
    1025                 1030                 1035             


Arg Gln  Ala Leu His Tyr Ala  Pro His Gln Met Lys  Asp Val Pro 
    1040                 1045                 1050             


Leu Ile  Ser Leu Ala Asn Ile  Leu His Asn Ala Lys  Leu Trp Asn 
    1055                 1060                 1065             


Asp Ala  Val Ile Val Ala Thr  Met Ala Val Glu Ile  Ala Pro His 
    1070                 1075                 1080             


Phe Ala  Val Asn His Phe Thr  Leu Gly Asn Val Tyr  Val Ala Met 
    1085                 1090                 1095             


Glu Glu  Phe Glu Lys Ala Leu  Val Trp Tyr Glu Ser  Thr Leu Lys 
    1100                 1105                 1110             


Leu Gln  Pro Glu Phe Val Pro  Ala Lys Asn Arg Ile  Gln Thr Ile 
    1115                 1120                 1125             


Gln Cys  His Leu Met Leu Lys  Lys Gly Arg Arg Ser  Pro 
    1130                 1135                 1140     


<210>  1263
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1263

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  1264
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1264

Met Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys 
1               5                   10                  15      


Lys Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val 
            20                  25                  30          


Leu Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu 
        35                  40                  45              


Lys Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  


Glu Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys 
                85                  90                  95      


Pro Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val 
            100                 105                 110         


Asn Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu 
        115                 120                 125             


Leu Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Leu Arg Phe Gly Val Asp Arg Pro Ser 
145                 150             


<210>  1265
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  1265

Met Ser Lys Val Ser Phe Lys Ile Thr Leu Thr Ser Asp Pro Arg Leu 
1               5                   10                  15      


Pro Tyr Lys Val Leu Ser Val Pro Glu Ser Thr Pro Phe Thr Ala Val 
            20                  25                  30          


Leu Lys Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr Ser Ala 
        35                  40                  45              


Ile Ile Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr Ala Gly 
    50                  55                  60                  


Asn Val Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro Arg Asp 
65                  70                  75                  80  


Arg Val Gly Ser Cys 
                85  


<210>  1266
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  1266

Met Ala Ala Thr Gly Ala Asn Ala Glu Lys Ala Glu Ser His Asn Asp 
1               5                   10                  15      


Cys Pro Val Arg Leu Leu Asn Pro Asn Ile Ala Lys Met Lys Glu Asp 
            20                  25                  30          


Ile Leu Tyr His Phe Asn Leu Thr Thr Ser Arg His Asn Phe Pro Ala 
        35                  40                  45              


Leu Phe Gly Asp Val Lys Phe Val Cys Val Gly Gly Ser Pro Ser Arg 
    50                  55                  60                  


Met Lys Ala Phe Ile Arg Cys Val Gly Ala Glu Leu Gly Leu Asp Cys 
65                  70                  75                  80  


Pro Gly Arg Asp Tyr Pro Asn Ile Cys Ala Gly Thr Asp Arg Tyr Ala 
                85                  90                  95      


Met Tyr Lys Val Gly Pro Val Leu Ser Val Ser His Gly Met Gly Ile 
            100                 105                 110         


Pro Ser Ile Ser Ile Met Leu His Glu Leu Ile Lys Leu Leu Tyr Tyr 
        115                 120                 125             


Ala Arg Cys Ser Asn Val Thr Ile Ile Arg Ile Gly Thr Ser Gly Gly 
    130                 135                 140                 


Ile Gly Leu Glu Pro Gly Thr Val Val Ile Thr Glu Gln Ala Val Asp 
145                 150                 155                 160 


Thr Cys Phe Lys Ala Glu Phe Glu Gln Ile Val Leu Gly Lys Arg Val 
                165                 170                 175     


Ile Arg Lys Thr Asp Leu Asn Lys Lys Leu Val Gln Glu Leu Leu Leu 
            180                 185                 190         


Cys Ser Ala Glu Leu Ser Glu Phe Thr Thr Val Val Gly Asn Thr Met 
        195                 200                 205             


Cys Thr Leu Asp Phe Tyr Glu Gly Gln Gly Arg Leu Asp Gly Ala Leu 
    210                 215                 220                 


Cys Ser Tyr Thr Glu Lys Asp Lys Gln Ala Tyr Leu Glu Ala Ala Tyr 
225                 230                 235                 240 


Ala Ala Gly Val Arg Asn Ile Glu Met Glu Ser Ser Val Phe Ala Ala 
                245                 250                 255     


Met Cys Ser Ala Cys Gly Leu Gln Ala Ala Val Val Cys Val Thr Leu 
            260                 265                 270         


Leu Asn Arg Leu Glu Gly Asp Gln Ile Ser Ser Pro Arg Asn Val Leu 
        275                 280                 285             


Ser Glu Tyr Gln Gln Arg Pro Gln Arg Leu Val Ser Tyr Phe Ile Lys 
    290                 295                 300                 


Lys Lys Leu Ser Lys Ala 
305                 310 


<210>  1267
<211>  3546
<212>  PRT
<213>  Homo sapiens

<400>  1267

Met Cys Glu Asn Cys Ala Asp Leu Val Glu Val Leu Asn Glu Ile Ser 
1               5                   10                  15      


Asp Val Glu Gly Gly Asp Gly Leu Gln Leu Arg Lys Glu His Thr Leu 
            20                  25                  30          


Lys Ile Phe Thr Tyr Ile Asn Ser Trp Thr Gln Arg Gln Cys Leu Cys 
        35                  40                  45              


Cys Phe Lys Glu Tyr Lys His Leu Glu Ile Phe Asn Gln Val Val Cys 
    50                  55                  60                  


Ala Leu Ile Asn Leu Val Ile Ala Gln Val Gln Val Leu Arg Asp Gln 
65                  70                  75                  80  


Leu Cys Lys His Cys Thr Thr Ile Asn Ile Asp Ser Thr Trp Gln Asp 
                85                  90                  95      


Glu Ser Asn Gln Ala Glu Glu Pro Leu Asn Ile Asp Arg Glu Cys Asn 
            100                 105                 110         


Glu Gly Ser Thr Glu Arg Gln Lys Ser Ile Glu Lys Lys Ser Asn Ser 
        115                 120                 125             


Thr Arg Ile Cys Asn Leu Thr Glu Glu Glu Ser Ser Lys Ser Ser Asp 
    130                 135                 140                 


Pro Phe Ser Leu Trp Ser Thr Asp Glu Lys Glu Lys Leu Leu Leu Cys 
145                 150                 155                 160 


Val Ala Lys Ile Phe Gln Ile Gln Phe Pro Leu Tyr Thr Ala Tyr Lys 
                165                 170                 175     


His Asn Thr His Pro Thr Ile Glu Asp Ile Ser Thr Gln Glu Ser Asn 
            180                 185                 190         


Ile Leu Gly Ala Phe Cys Asp Met Asn Asp Val Glu Val Pro Leu His 
        195                 200                 205             


Leu Leu Arg Tyr Val Cys Leu Phe Cys Gly Lys Asn Gly Leu Ser Leu 
    210                 215                 220                 


Met Lys Asp Cys Phe Glu Tyr Gly Thr Pro Glu Thr Leu Pro Phe Leu 
225                 230                 235                 240 


Ile Ala His Ala Phe Ile Thr Val Val Ser Asn Ile Arg Ile Trp Leu 
                245                 250                 255     


His Ile Pro Ala Val Met Gln His Ile Ile Pro Phe Arg Thr Tyr Val 
            260                 265                 270         


Ile Arg Tyr Leu Cys Lys Leu Ser Asp Gln Glu Leu Arg Gln Ser Ala 
        275                 280                 285             


Ala Arg Asn Met Ala Asp Leu Met Trp Ser Thr Val Lys Glu Pro Leu 
    290                 295                 300                 


Asp Thr Thr Leu Cys Phe Asp Lys Glu Ser Leu Asp Leu Ala Phe Lys 
305                 310                 315                 320 


Tyr Phe Met Ser Pro Thr Leu Thr Met Arg Leu Ala Gly Leu Ser Gln 
                325                 330                 335     


Ile Thr Asn Gln Leu His Thr Phe Asn Asp Val Cys Asn Asn Glu Ser 
            340                 345                 350         


Leu Val Ser Asp Thr Glu Thr Ser Ile Ala Lys Glu Leu Ala Asp Trp 
        355                 360                 365             


Leu Ile Ser Asn Asn Val Val Glu His Ile Phe Gly Pro Asn Leu His 
    370                 375                 380                 


Ile Glu Ile Ile Lys Gln Cys Gln Val Ile Leu Asn Phe Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Arg Leu Ser Thr Gln His Ile Asp Cys Ile Trp Ala Ala Ala 
                405                 410                 415     


Gln Leu Lys His Cys Ser Arg Tyr Ile His Asp Leu Phe Pro Ser Leu 
            420                 425                 430         


Ile Lys Asn Leu Asp Pro Val Pro Leu Arg His Leu Leu Asn Leu Val 
        435                 440                 445             


Ser Ala Leu Glu Pro Ser Val His Thr Glu Gln Thr Leu Tyr Leu Ala 
    450                 455                 460                 


Ser Met Leu Ile Lys Ala Leu Trp Asn Asn Ala Leu Ala Ala Lys Ala 
465                 470                 475                 480 


Gln Leu Ser Lys Gln Ser Ser Phe Ala Ser Leu Leu Asn Thr Asn Ile 
                485                 490                 495     


Pro Ile Gly Asn Lys Lys Glu Glu Glu Glu Leu Arg Arg Thr Ala Pro 
            500                 505                 510         


Ser Pro Trp Ser Pro Ala Ala Ser Pro Gln Ser Ser Asp Asn Ser Asp 
        515                 520                 525             


Thr His Gln Ser Gly Gly Ser Asp Ile Glu Met Asp Glu Gln Leu Ile 
    530                 535                 540                 


Asn Arg Thr Lys His Val Gln Gln Arg Leu Ser Asp Thr Glu Glu Ser 
545                 550                 555                 560 


Met Gln Gly Ser Ser Asp Glu Thr Ala Asn Ser Gly Glu Asp Gly Ser 
                565                 570                 575     


Ser Gly Pro Gly Ser Ser Ser Gly His Ser Asp Gly Ser Ser Asn Glu 
            580                 585                 590         


Val Asn Ser Ser His Ala Ser Gln Ser Ala Gly Ser Pro Gly Ser Glu 
        595                 600                 605             


Val Gln Ser Glu Asp Ile Ala Asp Ile Glu Ala Leu Lys Glu Glu Asp 
    610                 615                 620                 


Glu Asp Asp Asp His Gly His Asn Pro Pro Lys Ser Ser Cys Gly Thr 
625                 630                 635                 640 


Asp Leu Arg Asn Arg Lys Leu Glu Ser Gln Ala Gly Ile Cys Leu Gly 
                645                 650                 655     


Asp Ser Gln Gly Met Ser Glu Arg Asn Gly Thr Ser Ser Gly Thr Gly 
            660                 665                 670         


Lys Asp Leu Val Phe Asn Thr Glu Ser Leu Pro Ser Val Asp Asn Arg 
        675                 680                 685             


Met Arg Met Leu Asp Ala Cys Ser His Ser Glu Asp Pro Glu His Asp 
    690                 695                 700                 


Ile Ser Gly Glu Met Asn Ala Thr His Ile Ala Gln Gly Ser Gln Glu 
705                 710                 715                 720 


Ser Cys Ile Thr Arg Thr Gly Asp Phe Leu Gly Glu Thr Ile Gly Asn 
                725                 730                 735     


Glu Leu Phe Asn Cys Arg Gln Phe Ile Gly Pro Gln His His His His 
            740                 745                 750         


His His His His His His His His Asp Gly His Met Val Asp Asp Met 
        755                 760                 765             


Leu Ser Ala Asp Asp Val Ser Cys Ser Ser Ser Gln Val Ser Ala Lys 
    770                 775                 780                 


Ser Glu Lys Asn Met Ala Asp Phe Asp Gly Glu Glu Ser Gly Cys Glu 
785                 790                 795                 800 


Glu Glu Leu Val Gln Ile Asn Ser His Ala Glu Leu Thr Ser His Leu 
                805                 810                 815     


Gln Gln His Leu Pro Asn Leu Ala Ser Ile Tyr His Glu His Leu Ser 
            820                 825                 830         


Gln Gly Pro Val Val His Lys His Gln Phe Asn Ser Asn Ala Val Thr 
        835                 840                 845             


Asp Ile Asn Leu Asp Asn Val Cys Lys Lys Gly Asn Thr Leu Leu Trp 
    850                 855                 860                 


Asp Ile Val Gln Asp Glu Asp Ala Val Asn Leu Ser Glu Gly Leu Ile 
865                 870                 875                 880 


Asn Glu Ala Glu Lys Leu Leu Cys Ser Leu Val Cys Trp Phe Thr Asp 
                885                 890                 895     


Arg Gln Ile Arg Met Arg Phe Ile Glu Gly Cys Leu Glu Asn Leu Gly 
            900                 905                 910         


Asn Asn Arg Ser Val Val Ile Ser Leu Arg Leu Leu Pro Lys Leu Phe 
        915                 920                 925             


Gly Thr Phe Gln Gln Phe Gly Ser Ser Tyr Asp Thr His Trp Ile Thr 
    930                 935                 940                 


Met Trp Ala Glu Lys Glu Leu Asn Met Met Lys Leu Phe Phe Asp Asn 
945                 950                 955                 960 


Leu Val Tyr Tyr Ile Gln Thr Val Arg Glu Gly Arg Gln Lys His Ala 
                965                 970                 975     


Leu Tyr Ser His Ser Ala Glu Val Gln Val Arg Leu Gln Phe Leu Thr 
            980                 985                 990         


Cys Val Phe Ser Thr Leu Gly Ser  Pro Asp His Phe Arg  Leu Ser Leu 
        995                 1000                 1005             


Glu Gln  Val Asp Ile Leu Trp  His Cys Leu Val Glu  Asp Ser Glu 
    1010                 1015                 1020             


Cys Tyr  Asp Asp Ala Leu His  Trp Phe Leu Asn Gln  Val Arg Ser 
    1025                 1030                 1035             


Lys Asp  Gln His Ala Met Gly  Met Glu Thr Tyr Lys  His Leu Phe 
    1040                 1045                 1050             


Leu Glu  Lys Met Pro Gln Leu  Lys Pro Glu Thr Ile  Ser Met Thr 
    1055                 1060                 1065             


Gly Leu  Asn Leu Phe Gln His  Leu Cys Asn Leu Ala  Arg Leu Ala 
    1070                 1075                 1080             


Thr Ser  Ala Tyr Asp Gly Cys  Ser Asn Ser Glu Leu  Cys Gly Met 
    1085                 1090                 1095             


Asp Gln  Phe Trp Gly Ile Ala  Leu Arg Ala Gln Ser  Gly Asp Val 
    1100                 1105                 1110             


Ser Arg  Ala Ala Ile Gln Tyr  Ile Asn Ser Tyr Tyr  Ile Asn Gly 
    1115                 1120                 1125             


Lys Thr  Gly Leu Glu Lys Glu  Gln Glu Phe Ile Ser  Lys Cys Met 
    1130                 1135                 1140             


Glu Ser  Leu Met Ile Ala Ser  Ser Ser Leu Glu Gln  Glu Ser His 
    1145                 1150                 1155             


Ser Ser  Leu Met Val Ile Glu  Arg Gly Leu Leu Met  Leu Lys Thr 
    1160                 1165                 1170             


His Leu  Glu Ala Phe Arg Arg  Arg Phe Ala Tyr His  Leu Arg Gln 
    1175                 1180                 1185             


Trp Gln  Ile Glu Gly Thr Gly  Ile Ser Ser His Leu  Lys Ala Leu 
    1190                 1195                 1200             


Ser Asp  Lys Gln Ser Leu Pro  Leu Arg Val Val Cys  Gln Pro Ala 
    1205                 1210                 1215             


Gly Leu  Pro Asp Lys Met Thr  Ile Glu Met Tyr Pro  Ser Asp Gln 
    1220                 1225                 1230             


Val Ala  Asp Leu Arg Ala Glu  Val Thr His Trp Tyr  Glu Asn Leu 
    1235                 1240                 1245             


Gln Lys  Glu Gln Ile Asn Gln  Gln Ala Gln Leu Gln  Glu Phe Gly 
    1250                 1255                 1260             


Gln Ser  Asn Arg Lys Gly Glu  Phe Pro Gly Gly Leu  Met Gly Pro 
    1265                 1270                 1275             


Val Arg  Met Ile Ser Ser Gly  His Glu Leu Thr Thr  Asp Tyr Asp 
    1280                 1285                 1290             


Glu Lys  Ala Leu His Glu Leu  Gly Phe Lys Asp Met  Gln Met Val 
    1295                 1300                 1305             


Phe Val  Ser Leu Gly Ala Pro  Arg Arg Glu Arg Lys  Gly Glu Gly 
    1310                 1315                 1320             


Val Gln  Leu Pro Ala Ser Cys  Leu Pro Pro Pro Gln  Lys Asp Asn 
    1325                 1330                 1335             


Ile Pro  Met Leu Leu Leu Leu  Gln Glu Pro His Leu  Thr Thr Leu 
    1340                 1345                 1350             


Phe Asp  Leu Leu Glu Met Leu  Ala Ser Phe Lys Pro  Pro Ser Gly 
    1355                 1360                 1365             


Lys Val  Ala Val Asp Asp Ser  Glu Ser Leu Arg Cys  Glu Glu Leu 
    1370                 1375                 1380             


His Leu  His Ala Glu Asn Leu  Ser Arg Arg Val Trp  Glu Leu Leu 
    1385                 1390                 1395             


Met Leu  Leu Pro Thr Cys Pro  Asn Met Leu Met Ala  Phe Gln Asn 
    1400                 1405                 1410             


Ile Ser  Asp Glu Gln Ser Asn  Asp Gly Phe Asn Trp  Lys Glu Leu 
    1415                 1420                 1425             


Leu Lys  Ile Lys Ser Ala His  Lys Leu Leu Tyr Ala  Leu Glu Ile 
    1430                 1435                 1440             


Ile Glu  Ala Leu Gly Lys Pro  Asn Arg Arg Ile Arg  Arg Glu Ser 
    1445                 1450                 1455             


Thr Gly  Ser Tyr Ser Asp Leu  Tyr Pro Asp Ser Asp  Asp Ser Ser 
    1460                 1465                 1470             


Glu Asp  Gln Val Glu Asn Ser  Lys Asn Ser Trp Ser  Cys Lys Phe 
    1475                 1480                 1485             


Val Ala  Ala Gly Gly Leu Gln  Gln Leu Leu Glu Ile  Phe Asn Ser 
    1490                 1495                 1500             


Gly Ile  Leu Glu Pro Lys Glu  Gln Glu Ser Trp Thr  Val Trp Gln 
    1505                 1510                 1515             


Leu Asp  Cys Leu Ala Cys Leu  Leu Lys Leu Ile Cys  Gln Phe Ala 
    1520                 1525                 1530             


Val Asp  Pro Ser Asp Leu Asp  Leu Ala Tyr His Asp  Val Phe Ala 
    1535                 1540                 1545             


Trp Ser  Gly Ile Ala Glu Ser  His Arg Lys Arg Thr  Trp Pro Gly 
    1550                 1555                 1560             


Lys Ser  Arg Lys Ala Ala Gly  Asp His Ala Lys Gly  Leu His Ile 
    1565                 1570                 1575             


Pro Arg  Leu Thr Glu Val Phe  Leu Val Leu Val Gln  Gly Thr Ser 
    1580                 1585                 1590             


Leu Ile  Gln Arg Leu Met Ser  Val Ala Tyr Thr Tyr  Asp Asn Leu 
    1595                 1600                 1605             


Ala Pro  Arg Val Leu Lys Ala  Gln Ser Asp His Arg  Ser Arg His 
    1610                 1615                 1620             


Glu Val  Ser His Tyr Ser Met  Trp Leu Leu Val Ser  Trp Ala His 
    1625                 1630                 1635             


Cys Cys  Ser Leu Val Lys Ser  Ser Leu Ala Asp Ser  Asp His Leu 
    1640                 1645                 1650             


Gln Asp  Trp Leu Lys Lys Leu  Thr Leu Leu Ile Pro  Glu Thr Ala 
    1655                 1660                 1665             


Val Arg  His Glu Ser Cys Ser  Gly Leu Tyr Lys Leu  Ser Leu Ser 
    1670                 1675                 1680             


Gly Leu  Asp Gly Gly Asp Ser  Ile Asn Arg Ser Phe  Leu Leu Leu 
    1685                 1690                 1695             


Ala Ala  Ser Thr Leu Leu Lys  Phe Leu Pro Asp Ala  Gln Ala Leu 
    1700                 1705                 1710             


Lys Pro  Ile Arg Ile Asp Asp  Tyr Glu Glu Glu Pro  Ile Leu Lys 
    1715                 1720                 1725             


Pro Gly  Cys Lys Glu Tyr Phe  Trp Leu Leu Cys Lys  Leu Val Asp 
    1730                 1735                 1740             


Asn Ile  His Ile Lys Asp Ala  Ser Gln Thr Thr Leu  Leu Asp Leu 
    1745                 1750                 1755             


Asp Ala  Leu Ala Arg His Leu  Ala Asp Cys Ile Arg  Ser Arg Glu 
    1760                 1765                 1770             


Ile Leu  Asp His Gln Asp Gly  Asn Val Glu Asp Asp  Gly Leu Thr 
    1775                 1780                 1785             


Gly Leu  Leu Arg Leu Ala Thr  Ser Val Val Lys His  Lys Pro Pro 
    1790                 1795                 1800             


Phe Lys  Phe Ser Arg Glu Gly  Gln Glu Phe Leu Arg  Asp Ile Phe 
    1805                 1810                 1815             


Asn Leu  Leu Phe Leu Leu Pro  Ser Leu Lys Asp Arg  Gln Gln Pro 
    1820                 1825                 1830             


Lys Cys  Lys Ser His Ser Ser  Arg Ala Ala Ala Tyr  Asp Leu Leu 
    1835                 1840                 1845             


Val Glu  Met Val Lys Gly Ser  Val Glu Asn Tyr Arg  Leu Ile His 
    1850                 1855                 1860             


Asn Trp  Val Met Ala Gln His  Met Gln Ser His Ala  Pro Tyr Lys 
    1865                 1870                 1875             


Trp Asp  Tyr Trp Pro His Glu  Asp Val Arg Ala Glu  Cys Arg Phe 
    1880                 1885                 1890             


Val Gly  Leu Thr Asn Leu Gly  Ala Thr Cys Tyr Leu  Ala Ser Thr 
    1895                 1900                 1905             


Ile Gln  Gln Leu Tyr Met Ile  Pro Glu Ala Arg Gln  Ala Val Phe 
    1910                 1915                 1920             


Thr Ala  Lys Tyr Ser Glu Asp  Met Lys His Lys Thr  Thr Leu Leu 
    1925                 1930                 1935             


Glu Leu  Gln Lys Met Phe Thr  Tyr Leu Met Glu Ser  Glu Cys Lys 
    1940                 1945                 1950             


Ala Tyr  Asn Pro Arg Pro Phe  Cys Lys Thr Tyr Thr  Met Asp Lys 
    1955                 1960                 1965             


Gln Pro  Leu Asn Thr Gly Glu  Gln Lys Asp Met Thr  Glu Phe Phe 
    1970                 1975                 1980             


Thr Asp  Leu Ile Thr Lys Ile  Glu Glu Met Ser Pro  Glu Leu Lys 
    1985                 1990                 1995             


Asn Thr  Val Lys Ser Leu Phe  Gly Gly Val Ile Thr  Asn Asn Val 
    2000                 2005                 2010             


Val Ser  Leu Asp Cys Glu His  Val Ser Gln Thr Ala  Glu Glu Phe 
    2015                 2020                 2025             


Tyr Thr  Val Arg Cys Gln Val  Ala Asp Met Lys Asn  Ile Tyr Glu 
    2030                 2035                 2040             


Ser Leu  Asp Glu Val Thr Ile  Lys Asp Thr Leu Glu  Gly Asp Asn 
    2045                 2050                 2055             


Met Tyr  Thr Cys Ser His Cys  Gly Lys Lys Val Arg  Ala Glu Lys 
    2060                 2065                 2070             


Arg Ala  Cys Phe Lys Lys Leu  Pro Arg Ile Leu Ser  Phe Asn Thr 
    2075                 2080                 2085             


Met Arg  Tyr Thr Phe Asn Met  Val Thr Met Met Lys  Glu Lys Val 
    2090                 2095                 2100             


Asn Thr  His Phe Ser Phe Pro  Leu Arg Leu Asp Met  Thr Pro Tyr 
    2105                 2110                 2115             


Thr Glu  Asp Phe Leu Met Gly  Lys Ser Glu Arg Lys  Glu Gly Phe 
    2120                 2125                 2130             


Lys Glu  Val Ser Asp His Ser  Lys Asp Ser Glu Ser  Tyr Glu Tyr 
    2135                 2140                 2145             


Asp Leu  Ile Gly Val Thr Val  His Thr Gly Thr Ala  Asp Gly Gly 
    2150                 2155                 2160             


His Tyr  Tyr Ser Phe Ile Arg  Asp Ile Val Asn Pro  His Ala Tyr 
    2165                 2170                 2175             


Lys Asn  Asn Lys Trp Tyr Leu  Phe Asn Asp Ala Glu  Val Lys Pro 
    2180                 2185                 2190             


Phe Asp  Ser Ala Gln Leu Ala  Ser Glu Cys Phe Gly  Gly Glu Met 
    2195                 2200                 2205             


Thr Thr  Lys Thr Tyr Asp Ser  Val Thr Asp Lys Phe  Met Asp Phe 
    2210                 2215                 2220             


Ser Phe  Glu Lys Thr His Ser  Ala Tyr Met Leu Phe  Tyr Lys Arg 
    2225                 2230                 2235             


Met Glu  Pro Glu Glu Glu Asn  Gly Arg Glu Tyr Lys  Phe Asp Val 
    2240                 2245                 2250             


Ser Ser  Glu Leu Leu Glu Trp  Ile Trp His Asp Asn  Met Gln Phe 
    2255                 2260                 2265             


Leu Gln  Asp Lys Asn Ile Phe  Glu His Thr Tyr Phe  Gly Phe Met 
    2270                 2275                 2280             


Trp Gln  Leu Cys Ser Cys Ile  Pro Ser Thr Leu Pro  Asp Pro Lys 
    2285                 2290                 2295             


Ala Val  Ser Leu Met Thr Ala  Lys Leu Ser Thr Ser  Phe Val Leu 
    2300                 2305                 2310             


Glu Thr  Phe Ile His Ser Lys  Glu Lys Pro Thr Met  Leu Gln Trp 
    2315                 2320                 2325             


Ile Glu  Leu Leu Thr Lys Gln  Phe Asn Asn Ser Gln  Ala Ala Cys 
    2330                 2335                 2340             


Glu Trp  Phe Leu Asp Arg Met  Ala Asp Asp Asp Trp  Trp Pro Met 
    2345                 2350                 2355             


Gln Ile  Leu Ile Lys Cys Pro  Asn Gln Ile Val Arg  Gln Met Phe 
    2360                 2365                 2370             


Gln Arg  Leu Cys Ile His Val  Ile Gln Arg Leu Arg  Pro Val His 
    2375                 2380                 2385             


Ala His  Leu Tyr Leu Gln Pro  Gly Met Glu Asp Gly  Ser Asp Asp 
    2390                 2395                 2400             


Met Asp  Thr Ser Val Glu Asp  Ile Gly Gly Arg Ser  Cys Val Thr 
    2405                 2410                 2415             


Arg Phe  Val Arg Thr Leu Leu  Leu Ile Met Glu His  Gly Val Lys 
    2420                 2425                 2430             


Pro His  Ser Lys His Leu Thr  Glu Tyr Phe Ala Phe  Leu Tyr Glu 
    2435                 2440                 2445             


Phe Ala  Lys Met Gly Glu Glu  Glu Ser Gln Phe Leu  Leu Ser Leu 
    2450                 2455                 2460             


Gln Ala  Ile Ser Thr Met Val  His Phe Tyr Met Gly  Thr Lys Gly 
    2465                 2470                 2475             


Pro Glu  Asn Pro Gln Val Glu  Val Leu Ser Glu Glu  Glu Gly Glu 
    2480                 2485                 2490             


Glu Glu  Glu Glu Glu Glu Asp  Ile Leu Ser Leu Ala  Glu Glu Lys 
    2495                 2500                 2505             


Tyr Arg  Pro Ala Ala Leu Glu  Lys Met Ile Ala Leu  Val Ala Leu 
    2510                 2515                 2520             


Leu Val  Glu Gln Ser Arg Ser  Glu Arg His Leu Thr  Leu Ser Gln 
    2525                 2530                 2535             


Thr Asp  Met Ala Ala Leu Thr  Gly Gly Lys Gly Phe  Pro Phe Leu 
    2540                 2545                 2550             


Phe Gln  His Ile Arg Asp Gly  Ile Asn Ile Arg Gln  Thr Cys Asn 
    2555                 2560                 2565             


Leu Ile  Phe Ser Leu Cys Arg  Tyr Asn Asn Arg Leu  Ala Glu His 
    2570                 2575                 2580             


Ile Val  Ser Met Leu Phe Thr  Ser Ile Ala Lys Leu  Thr Pro Glu 
    2585                 2590                 2595             


Ala Ala  Asn Pro Phe Phe Lys  Leu Leu Thr Met Leu  Met Glu Phe 
    2600                 2605                 2610             


Ala Gly  Gly Pro Pro Gly Met  Pro Pro Phe Ala Ser  Tyr Ile Leu 
    2615                 2620                 2625             


Gln Arg  Ile Trp Glu Val Ile  Glu Tyr Asn Pro Ser  Gln Cys Leu 
    2630                 2635                 2640             


Asp Trp  Leu Ala Val Gln Thr  Pro Arg Asn Lys Leu  Ala His Ser 
    2645                 2650                 2655             


Trp Val  Leu Gln Asn Met Glu  Asn Trp Val Glu Arg  Phe Leu Leu 
    2660                 2665                 2670             


Ala His  Asn Tyr Pro Arg Val  Arg Thr Ser Ala Ala  Tyr Leu Leu 
    2675                 2680                 2685             


Val Ser  Leu Ile Pro Ser Asn  Ser Phe Arg Gln Met  Phe Arg Ser 
    2690                 2695                 2700             


Thr Arg  Ser Leu His Ile Pro  Thr Arg Asp Leu Pro  Leu Ser Pro 
    2705                 2710                 2715             


Asp Thr  Thr Val Val Leu His  Gln Val Tyr Asn Val  Leu Leu Gly 
    2720                 2725                 2730             


Leu Leu  Ser Arg Ala Lys Leu  Tyr Val Asp Ala Ala  Val His Gly 
    2735                 2740                 2745             


Thr Thr  Lys Leu Val Pro Tyr  Phe Ser Phe Met Thr  Tyr Cys Leu 
    2750                 2755                 2760             


Ile Ser  Lys Thr Glu Lys Leu  Met Phe Ser Thr Tyr  Phe Met Asp 
    2765                 2770                 2775             


Leu Trp  Asn Leu Phe Gln Pro  Lys Leu Ser Glu Pro  Ala Ile Ala 
    2780                 2785                 2790             


Thr Asn  His Asn Lys Gln Ala  Leu Leu Ser Phe Trp  Tyr Asn Val 
    2795                 2800                 2805             


Cys Ala  Asp Cys Pro Glu Asn  Ile Arg Leu Ile Val  Gln Asn Pro 
    2810                 2815                 2820             


Val Val  Thr Lys Asn Ile Ala  Phe Asn Tyr Ile Leu  Ala Asp His 
    2825                 2830                 2835             


Asp Asp  Gln Asp Val Val Leu  Phe Asn Arg Gly Met  Leu Pro Ala 
    2840                 2845                 2850             


Tyr Tyr  Gly Ile Leu Arg Leu  Cys Cys Glu Gln Ser  Pro Ala Phe 
    2855                 2860                 2865             


Thr Arg  Gln Leu Ala Ser His  Gln Asn Ile Gln Trp  Ala Phe Lys 
    2870                 2875                 2880             


Asn Leu  Thr Pro His Ala Ser  Gln Tyr Pro Gly Ala  Val Glu Glu 
    2885                 2890                 2895             


Leu Phe  Asn Leu Met Gln Leu  Phe Ile Ala Gln Arg  Pro Asp Met 
    2900                 2905                 2910             


Arg Glu  Glu Glu Leu Glu Asp  Ile Lys Gln Phe Lys  Lys Thr Thr 
    2915                 2920                 2925             


Ile Ser  Cys Tyr Leu Arg Cys  Leu Asp Gly Arg Ser  Cys Trp Thr 
    2930                 2935                 2940             


Thr Leu  Ile Ser Ala Phe Arg  Ile Leu Leu Glu Ser  Asp Glu Asp 
    2945                 2950                 2955             


Arg Leu  Leu Val Val Phe Asn  Arg Gly Leu Ile Leu  Met Thr Glu 
    2960                 2965                 2970             


Ser Phe  Asn Thr Leu His Met  Met Tyr His Glu Ala  Thr Ala Cys 
    2975                 2980                 2985             


His Val  Thr Gly Asp Leu Val  Glu Leu Leu Ser Ile  Phe Leu Ser 
    2990                 2995                 3000             


Val Leu  Lys Ser Thr Arg Pro  Tyr Leu Gln Arg Lys  Asp Val Lys 
    3005                 3010                 3015             


Gln Ala  Leu Ile Gln Trp Gln  Glu Arg Ile Glu Phe  Ala His Lys 
    3020                 3025                 3030             


Leu Leu  Thr Leu Leu Asn Ser  Tyr Ser Pro Pro Glu  Leu Arg Asn 
    3035                 3040                 3045             


Ala Cys  Ile Asp Val Leu Lys  Glu Leu Val Leu Leu  Ser Pro His 
    3050                 3055                 3060             


Asp Phe  Leu His Thr Leu Val  Pro Phe Leu Gln His  Asn His Cys 
    3065                 3070                 3075             


Thr Tyr  His His Ser Asn Ile  Pro Met Ser Leu Gly  Pro Tyr Phe 
    3080                 3085                 3090             


Pro Cys  Arg Glu Asn Ile Lys  Leu Ile Gly Gly Lys  Ser Asn Ile 
    3095                 3100                 3105             


Arg Pro  Pro Arg Pro Glu Leu  Asn Met Cys Leu Leu  Pro Thr Met 
    3110                 3115                 3120             


Val Glu  Thr Ser Lys Gly Lys  Asp Asp Val Tyr Asp  Arg Met Leu 
    3125                 3130                 3135             


Leu Asp  Tyr Phe Phe Ser Tyr  His Gln Phe Ile His  Leu Leu Cys 
    3140                 3145                 3150             


Arg Val  Ala Ile Asn Cys Glu  Lys Phe Thr Glu Thr  Leu Val Lys 
    3155                 3160                 3165             


Leu Ser  Val Leu Val Ala Tyr  Glu Gly Leu Pro Leu  His Leu Ala 
    3170                 3175                 3180             


Leu Phe  Pro Lys Leu Trp Thr  Glu Leu Cys Gln Thr  Gln Ser Ala 
    3185                 3190                 3195             


Met Ser  Lys Asn Cys Ile Lys  Leu Leu Cys Glu Asp  Pro Val Phe 
    3200                 3205                 3210             


Ala Glu  Tyr Ile Lys Cys Ile  Leu Met Asp Glu Arg  Thr Phe Leu 
    3215                 3220                 3225             


Asn Asn  Asn Ile Val Tyr Thr  Phe Met Thr His Phe  Leu Leu Lys 
    3230                 3235                 3240             


Val Gln  Ser Gln Val Phe Ser  Glu Ala Asn Cys Ala  Asn Leu Ile 
    3245                 3250                 3255             


Ser Thr  Leu Ile Thr Asn Leu  Ile Ser Gln Tyr Gln  Asn Leu Gln 
    3260                 3265                 3270             


Ser Asp  Phe Ser Asn Arg Val  Glu Ile Ser Lys Ala  Ser Ala Ser 
    3275                 3280                 3285             


Leu Asn  Gly Asp Leu Arg Ala  Leu Ala Leu Leu Leu  Ser Val His 
    3290                 3295                 3300             


Thr Pro  Lys Gln Leu Asn Pro  Ala Leu Ile Pro Thr  Leu Gln Glu 
    3305                 3310                 3315             


Leu Leu  Ser Lys Cys Arg Thr  Cys Leu Gln Gln Arg  Asn Ser Leu 
    3320                 3325                 3330             


Gln Glu  Gln Glu Ala Lys Glu  Arg Lys Thr Lys Asp  Asp Glu Gly 
    3335                 3340                 3345             


Ala Thr  Pro Ile Lys Arg Arg  Arg Val Ser Ser Asp  Glu Glu His 
    3350                 3355                 3360             


Thr Val  Asp Ser Cys Ile Ser  Asp Met Lys Thr Glu  Thr Arg Glu 
    3365                 3370                 3375             


Val Leu  Thr Pro Thr Ser Thr  Ser Asp Asn Glu Thr  Arg Asp Ser 
    3380                 3385                 3390             


Ser Ile  Ile Asp Pro Gly Thr  Glu Gln Asp Leu Pro  Ser Pro Glu 
    3395                 3400                 3405             


Asn Ser  Ser Val Lys Glu Tyr  Arg Met Glu Val Pro  Ser Ser Phe 
    3410                 3415                 3420             


Ser Glu  Asp Met Ser Asn Ile  Arg Ser Gln His Ala  Glu Glu Gln 
    3425                 3430                 3435             


Ser Asn  Asn Gly Arg Tyr Asp  Asp Cys Lys Glu Phe  Lys Asp Leu 
    3440                 3445                 3450             


His Cys  Ser Lys Asp Ser Thr  Leu Ala Glu Glu Glu  Ser Glu Phe 
    3455                 3460                 3465             


Pro Ser  Thr Ser Ile Ser Ala  Val Leu Ser Asp Leu  Ala Asp Leu 
    3470                 3475                 3480             


Arg Ser  Cys Asp Gly Gln Ala  Leu Pro Ser Gln Asp  Pro Glu Val 
    3485                 3490                 3495             


Ala Leu  Ser Leu Ser Cys Gly  His Ser Arg Gly Leu  Phe Ser His 
    3500                 3505                 3510             


Met Gln  Gln His Asp Ile Leu  Asp Thr Leu Cys Arg  Thr Ile Glu 
    3515                 3520                 3525             


Ser Thr  Ile His Val Val Thr  Arg Ile Ser Gly Lys  Gly Asn Gln 
    3530                 3535                 3540             


Ala Ala  Ser 
    3545     


<210>  1268
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1268

Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln 
1               5                   10                  15      


Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
            20                  25                  30          


Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
        35                  40                  45              


Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
    50                  55                  60                  


Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala 
65                  70                  75                  80  


Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp 
                85                  90                  95      


Val Val Ser Ser 
            100 


<210>  1269
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  1269

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
    370                 375                 380                 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
385                 390                 395                 400 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
                405                 410                 415     


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            420                 425                 430         


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
        435                 440                 445             


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
    450                 455                 460                 


Lys Leu Ser Phe Asp Phe Gln 
465                 470     


<210>  1270
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  1270

Met Ser Gly Gly Pro Met Gly Gly Arg Pro Gly Gly Arg Gly Ala Pro 
1               5                   10                  15      


Ala Val Gln Gln Asn Ile Pro Ser Thr Leu Leu Gln Asp His Glu Asn 
            20                  25                  30          


Gln Arg Leu Phe Glu Met Leu Gly Arg Lys Cys Leu Thr Leu Ala Thr 
        35                  40                  45              


Ala Val Val Gln Leu Tyr Leu Ala Leu Pro Pro Gly Ala Glu His Trp 
    50                  55                  60                  


Thr Lys Glu His Cys Gly Ala Val Cys Phe Val Lys Asp Asn Pro Gln 
65                  70                  75                  80  


Lys Ser Tyr Phe Ile Arg Leu Tyr Gly Leu Gln Ala Gly Arg Leu Leu 
                85                  90                  95      


Trp Glu Gln Glu Leu Tyr Ser Gln Leu Val Tyr Ser Thr Pro Thr Pro 
            100                 105                 110         


Phe Phe His Thr Phe Ala Gly Asp Asp Cys Gln Ala Gly Leu Asn Phe 
        115                 120                 125             


Ala Asp Glu Asp Glu Ala Gln Ala Phe Arg Ala Leu Val Gln Glu Lys 
    130                 135                 140                 


Ile Gln Lys Arg Asn Gln Arg Gln Ser Gly Asp Arg Arg Gln Leu Pro 
145                 150                 155                 160 


Pro Pro Pro Thr Pro Ala Asn Glu Glu Arg Arg Gly Gly Leu Pro Pro 
                165                 170                 175     


Leu Pro Leu His Pro Gly Gly Asp Gln Gly Gly Pro Pro Val Gly Pro 
            180                 185                 190         


Leu Ser Leu Gly Leu Ala Thr Val Asp Ile Gln Asn Pro Asp Ile Thr 
        195                 200                 205             


Ser Ser Arg Tyr Arg Gly Leu Pro Ala Pro Gly Pro Ser Pro Ala Asp 
    210                 215                 220                 


Lys Lys Arg Ser Gly Lys Lys Lys Ile Ser Lys Ala Asp Ile Gly Ala 
225                 230                 235                 240 


Pro Ser Gly Phe Lys His Val Ser His Val Gly Trp Asp Pro Gln Asn 
                245                 250                 255     


Gly Phe Asp Val Asn Asn Leu Asp Pro Asp Leu Arg Ser Leu Phe Ser 
            260                 265                 270         


Arg Ala Gly Ile Ser Glu Ala Gln Leu Thr Asp Ala Glu Thr Ser Lys 
        275                 280                 285             


Leu Ile Tyr Asp Phe Ile Glu Asp Gln Gly Gly Leu Glu Ala Val Arg 
    290                 295                 300                 


Gln Glu Met Arg Arg Gln Glu Pro Leu Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Arg Gly Gly Asn Gln Leu Pro Arg Pro Pro Ile Val Gly Gly Asn Lys 
                325                 330                 335     


Gly Arg Ser Gly Pro Leu Pro Pro Val Pro Leu Gly Ile Ala Pro Pro 
            340                 345                 350         


Pro Pro Thr Pro Arg Gly Pro Pro Pro Pro Gly Arg Gly Gly Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Ala Thr Gly Arg Ser Gly Pro Leu Pro Pro Pro 
    370                 375                 380                 


Pro Pro Gly Ala Gly Gly Pro Pro Met Pro Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ser Ser Gly Asn Gly Pro Ala Pro Pro Pro Leu Pro 
                405                 410                 415     


Pro Ala Leu Val Pro Ala Gly Gly Leu Ala Pro Gly Gly Gly Arg Gly 
            420                 425                 430         


Ala Leu Leu Asp Gln Ile Arg Gln Gly Ile Gln Leu Asn Lys Thr Pro 
        435                 440                 445             


Gly Ala Pro Glu Ser Ser Ala Leu Gln Pro Pro Pro Gln Ser Ser Glu 
    450                 455                 460                 


Gly Leu Val Gly Ala Leu Met His Val Met Gln Lys Arg Ser Arg Ala 
465                 470                 475                 480 


Ile His Ser Ser Asp Glu Gly Glu Asp Gln Ala Gly Asp Glu Asp Glu 
                485                 490                 495     


Asp Asp Glu Trp Asp Asp 
            500         


<210>  1271
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  1271

Met Ile Ala Pro Leu Leu Cys Ile Leu Ser Tyr Asn Phe Asn Thr Phe 
1               5                   10                  15      


Ala Ile Leu Asn Val Tyr Ser Lys Leu Thr Met Phe Cys Thr Thr Asn 
            20                  25                  30          


Ser Leu Pro Met Asp Leu Leu Leu Lys Gln Gly Ser Leu Lys Gln Glu 
        35                  40                  45              


Val Glu Ser Phe Cys Tyr Gln Ile Val Ser Glu Ser Asn Asp Gln Lys 
    50                  55                  60                  


Val Gly Ile Leu Gln Ser Glu Asp Lys Gln Leu Gln Pro Ser Val Ser 
65                  70                  75                  80  


Lys Lys Ser Glu Gly Glu Leu Ser Arg Val Lys Phe Ile Ser Asn Ser 
                85                  90                  95      


Asn Lys Ile Thr Phe Ser Lys Lys Pro Lys Arg Arg Lys Tyr Asp Glu 
            100                 105                 110         


Ser Tyr Leu Ser Phe Gly Phe Thr Tyr Phe Gly Asn Arg Asp Ala Pro 
        115                 120                 125             


His Ala Gln Cys Val Leu Cys Lys Lys Ile Leu Ser Asn Ser Ser Leu 
    130                 135                 140                 


Ala Pro Ser Lys Leu Arg Arg His Leu Glu Thr Lys His Ala Ala Tyr 
145                 150                 155                 160 


Lys Asp Lys Asp Ile Ser Phe Phe Lys Gln His Leu Asp Ser Pro Glu 
                165                 170                 175     


Asn Asn Lys Pro Pro Thr Pro Lys Ile Val Asn Thr Asp Asn Glu Ser 
            180                 185                 190         


Ala Thr Glu Ala Ser Tyr Asn Val Ser Tyr His Ile Ala Leu Ser Gly 
        195                 200                 205             


Glu Ala His Thr Ile Gly Glu Leu Leu Ile Lys Pro Cys Ala Lys Asp 
    210                 215                 220                 


Val Val Met Arg Met Phe Asp Glu Gln Tyr Ser Lys Lys Ile Asp Ala 
225                 230                 235                 240 


Val Gln Leu Ser Asn Ser Thr Val Ala Arg Arg Ile Lys Asp Leu Ala 
                245                 250                 255     


Ala Asp Ile Glu Glu Glu Leu Val Cys Arg Leu Lys Ile Cys Asp Gly 
            260                 265                 270         


Phe Ser Leu Gln Leu Asp Glu Ser Ala Asp Val Ser Gly Leu Ala Val 
        275                 280                 285             


Leu Leu Val Phe Val Arg Tyr Arg Phe Asn Lys Ser Ile Glu Glu Asp 
    290                 295                 300                 


Leu Leu Leu Cys Glu Ser Leu Gln Ser Asn Ala Thr Gly Glu Glu Ile 
305                 310                 315                 320 


Phe Asn Cys Ile Asn Ser Phe Met Gln Lys His Glu Ile Glu Trp Glu 
                325                 330                 335     


Lys Cys Val Asp Val Cys Ser Asp Ala Ser Arg Ala Val Asp Gly Lys 
            340                 345                 350         


Ile Ala Glu Ala Val Thr Leu Ile Lys Tyr Val Ala Pro Glu Ser Thr 
        355                 360                 365             


Ser Ser His Cys Leu Leu Tyr Arg His Ala Leu Ala Val Lys Ile Met 
    370                 375                 380                 


Pro Thr Ser Leu Lys Asn Val Leu Asp Gln Ala Val Gln Ile Ile Asn 
385                 390                 395                 400 


Tyr Ile Lys Ala Arg Pro His Gln Ser Arg Leu Leu Lys Ile Leu Cys 
                405                 410                 415     


Glu Glu Met Gly Ala Gln His Thr Ala Leu Leu Leu Asn Thr Glu Val 
            420                 425                 430         


Arg Trp Leu Ser Arg Gly Lys Val Leu Val Arg Leu Phe Glu Leu Arg 
        435                 440                 445             


Arg Glu Leu Leu Val Phe Met Asp Ser Ala Phe Arg Leu Ser Asp Cys 
    450                 455                 460                 


Leu Thr Asn Ser Ser Trp Leu Leu Arg Leu Ala Tyr Leu Ala Asp Ile 
465                 470                 475                 480 


Phe Thr Lys Leu Asn Glu Val Asn Leu Ser Met Gln Gly Lys Asn Val 
                485                 490                 495     


Thr Val Phe Thr Val Phe Asp Lys Met Ser Ser Leu Leu Arg Lys Leu 
            500                 505                 510         


Glu Phe Trp Ala Ser Ser Val Glu Glu Glu Asn Phe Asp Cys Phe Pro 
        515                 520                 525             


Thr Leu Ser Asp Phe Leu Thr Glu Ile Asn Ser Thr Val Asp Lys Asp 
    530                 535                 540                 


Ile Cys Ser Ala Ile Val Gln His Leu Arg Gly Leu Arg Ala Thr Leu 
545                 550                 555                 560 


Leu Lys Tyr Phe Pro Val Thr Asn Asp Asn Asn Ala Trp Val Arg Asn 
                565                 570                 575     


Pro Phe Thr Val Thr Val Lys Pro Ala Ser Leu Val Ala Arg Asp Tyr 
            580                 585                 590         


Glu Ser Leu Ile Asp Leu Thr Ser Asp Ser Gln Val Lys Gln Asn Phe 
        595                 600                 605             


Ser Glu Leu Ser Leu Asn Asp Phe Trp Ser Ser Leu Ile Gln Glu Tyr 
    610                 615                 620                 


Pro Ser Ile Ala Arg Arg Ala Val Arg Val Leu Leu Pro Phe Ala Thr 
625                 630                 635                 640 


Met His Leu Cys Glu Thr Gly Phe Ser Tyr Tyr Ala Ala Thr Lys Thr 
                645                 650                 655     


Lys Tyr Arg Lys Arg Leu Asp Ala Ala Pro His Met Arg Ile Arg Leu 
            660                 665                 670         


Ser Asn Ile Thr Pro Asn Ile Lys Arg Ile Cys Asp Lys Lys Thr Gln 
        675                 680                 685             


Lys His Cys Ser His 
    690             


<210>  1272
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  1272

Met Ala Arg Leu Thr Lys Arg Arg Gln Ala Asp Thr Lys Ala Ile Gln 
1               5                   10                  15      


His Leu Trp Ala Ala Ile Glu Ile Ile Arg Asn Gln Lys Gln Ile Ala 
            20                  25                  30          


Asn Ile Asp Arg Ile Thr Lys Tyr Met Ser Arg Val His Gly Met His 
        35                  40                  45              


Pro Lys Glu Thr Thr Arg Gln Leu Ser Leu Ala Val Lys Asp Gly Leu 
    50                  55                  60                  


Ile Val Glu Thr Leu Thr Val Gly Cys Lys Gly Ser Lys Ala Gly Ile 
65                  70                  75                  80  


Glu Gln Glu Gly Tyr Trp Leu Pro Gly Asp Glu Ile Asp Trp Glu Thr 
                85                  90                  95      


Glu Asn His Asp Trp Tyr Cys Phe Glu Cys His Leu Pro Gly Glu Val 
            100                 105                 110         


Leu Ile Cys Asp Leu Cys Phe Arg Val Tyr His Ser Lys Cys Leu Ser 
        115                 120                 125             


Asp Glu Phe Arg Leu Arg Asp Ser Ser Ser Pro Trp Gln Cys Pro Val 
    130                 135                 140                 


Cys Arg Ser Ile Lys Lys Lys Asn Thr Asn Lys Gln Glu Met Gly Thr 
145                 150                 155                 160 


Tyr Leu Arg Phe Ile Val Ser Arg Met Lys Glu Arg Ala Ile Asp Leu 
                165                 170                 175     


Asn Lys Lys Gly Lys Asp Asn Lys His Pro Met Tyr Arg Arg Leu Val 
            180                 185                 190         


His Ser Ala Val Asp Val Pro Thr Ile Gln Glu Lys Val Asn Glu Gly 
        195                 200                 205             


Lys Tyr Arg Ser Tyr Glu Glu Phe Lys Ala Asp Ala Gln Leu Leu Leu 
    210                 215                 220                 


His Asn Thr Val Ile Phe Tyr Gly Ala Asp Ser Glu Gln Ala Asp Ile 
225                 230                 235                 240 


Ala Arg Met Leu Tyr Lys Asp Thr Cys His Glu Leu Asp Glu Leu Gln 
                245                 250                 255     


Leu Cys Lys Asn Cys Phe Tyr Leu Ser Asn Ala Arg Pro Asp Asn Trp 
            260                 265                 270         


Phe Cys Tyr Pro Cys Ile Pro Asn His Glu Leu Val Trp Ala Lys Met 
        275                 280                 285             


Lys Gly Phe Gly Phe Trp Pro Ala Lys Val Met Gln Lys Glu Asp Asn 
    290                 295                 300                 


Gln Val Asp Val Arg Phe Phe Gly His His His Gln Arg Ala Trp Ile 
305                 310                 315                 320 


Pro Ser Glu Asn Ile Gln Asp Ile Thr Val Asn Ile His Arg Leu His 
                325                 330                 335     


Val Lys Arg Ser Met Gly Trp Lys Lys Ala Cys Asp Glu Leu Glu Leu 
            340                 345                 350         


His Gln Arg Phe Leu Arg Glu Gly Arg Phe Trp Lys Ser Lys Asn Glu 
        355                 360                 365             


Asp Arg Gly Glu Glu Glu Ala Glu Ser Ser Ile Ser Ser Thr Ser Asn 
    370                 375                 380                 


Glu Gln Leu Lys Val Thr Gln Glu Pro Arg Ala Lys Lys Gly Arg Arg 
385                 390                 395                 400 


Asn Gln Ser Val Glu Pro Lys Lys Glu Glu Pro Glu Pro Glu Thr Glu 
                405                 410                 415     


Ala Val Ser Ser Ser Gln Glu Ile Pro Thr Met Pro Gln Pro Ile Glu 
            420                 425                 430         


Lys Val Ser Val Ser Thr Gln Thr Lys Lys Leu Ser Ala Ser Ser Pro 
        435                 440                 445             


Arg Met Leu His Arg Ser Thr Gln Thr Thr Asn Asp Gly Val Cys Gln 
    450                 455                 460                 


Ser Met Cys His Asp Lys Tyr Thr Lys Ile Phe Asn Asp Phe Lys Asp 
465                 470                 475                 480 


Arg Met Lys Ser Asp His Lys Arg Glu Thr Glu Arg Val Val Arg Glu 
                485                 490                 495     


Ala Leu Glu Lys Leu Arg Ser Glu Met Glu Glu Glu Lys Arg Gln Ala 
            500                 505                 510         


Val Asn Lys Ala Val Ala Asn Met Gln Gly Glu Met Asp Arg Lys Cys 
        515                 520                 525             


Lys Gln Val Lys Glu Lys Cys Lys Glu Glu Phe Val Glu Glu Ile Lys 
    530                 535                 540                 


Lys Leu Ala Thr Gln His Lys Gln Leu Ile Ser Gln Thr Lys Lys Lys 
545                 550                 555                 560 


Gln Trp Cys Tyr Asn Cys Glu Glu Glu Ala Met Tyr His Cys Cys Trp 
                565                 570                 575     


Asn Thr Ser Tyr Cys Ser Ile Lys Cys Gln Gln Glu His Trp His Ala 
            580                 585                 590         


Glu His Lys Arg Thr Cys Arg Arg Lys Arg 
        595                 600         


<210>  1273
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  1273

Met Leu Glu Asn Tyr Lys Asn Leu Ala Thr Val Gly Tyr Gln Leu Phe 
1               5                   10                  15      


Lys Pro Ser Leu Ile Ser Trp Leu Glu Gln Glu Glu Ser Arg Thr Val 
            20                  25                  30          


Gln Arg Gly Asp Phe Gln Ala Ser Glu Trp Lys Val Gln Leu Lys Thr 
        35                  40                  45              


Lys Glu Leu Ala Leu Gln Gln Asp Val Leu Gly Glu Pro Thr Ser Ser 
    50                  55                  60                  


Gly Ile Gln Met Ile Gly Ser His Asn Gly Gly Glu Val Ser Asp Val 
65                  70                  75                  80  


Lys Gln Cys Gly Asp Val Ser Ser Glu His Ser Cys Leu Lys Thr His 
                85                  90                  95      


Val Arg Thr Gln Asn Ser Glu Asn Thr Phe Glu Cys Tyr Leu Tyr Gly 
            100                 105                 110         


Val Asp Phe Leu Thr Leu His Lys Lys Thr Ser Thr Gly Glu Gln Arg 
        115                 120                 125             


Ser Val Phe Ser Gln Cys Gly Lys Ala Phe Ser Leu Asn Pro Asp Val 
    130                 135                 140                 


Val Cys Gln Arg Thr Cys Thr Gly Glu Lys Ala Phe Asp Cys Ser Asp 
145                 150                 155                 160 


Ser Gly Lys Ser Phe Ile Asn His Ser His Leu Gln Gly His Leu Arg 
                165                 170                 175     


Thr His Asn Gly Glu Ser Leu His Glu Trp Lys Glu Cys Gly Arg Gly 
            180                 185                 190         


Phe Ile His Ser Thr Asp Leu Ala Val Arg Ile Gln Thr His Arg Ser 
        195                 200                 205             


Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Gly Phe Arg Tyr Ser 
    210                 215                 220                 


Ala Tyr Leu Asn Ile His Met Gly Thr His Thr Gly Asp Asn Pro Tyr 
225                 230                 235                 240 


Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr Arg Ser Cys Gln Leu Thr 
                245                 250                 255     


Gln His Arg Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Asp 
            260                 265                 270         


Cys Gly Arg Ala Phe Thr Val Ser Ser Cys Leu Ser Gln His Met Lys 
        275                 280                 285             


Ile His Val Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Ile Ala 
    290                 295                 300                 


Phe Thr Arg Ser Ser Gln Leu Thr Glu His Leu Lys Thr His Thr Ala 
305                 310                 315                 320 


Lys Asp Pro Phe Glu Cys Lys Ile Cys Gly Lys Ser Phe Arg Asn Ser 
                325                 330                 335     


Ser Cys Leu Ser Asp His Phe Arg Ile His Thr Gly Ile Lys Pro Tyr 
            340                 345                 350         


Lys Cys Lys Asp Cys Gly Lys Ala Phe Thr Gln Asn Ser Asp Leu Thr 
        355                 360                 365             


Lys His Ala Arg Thr His Ser Gly Glu Arg Pro Tyr Glu Cys Lys Glu 
    370                 375                 380                 


Cys Gly Lys Ala Phe Ala Arg Ser Ser Arg Leu Ser Glu His Thr Arg 
385                 390                 395                 400 


Thr His Thr Gly Glu Lys Pro Phe Glu Cys Val Lys Cys Gly Lys Ala 
                405                 410                 415     


Phe Ala Ile Ser Ser Asn Leu Ser Gly His Leu Arg Ile His Thr Gly 
            420                 425                 430         


Glu Lys Pro Phe Glu Cys Leu Glu Cys Gly Lys Ala Phe Thr His Ser 
        435                 440                 445             


Ser Ser Leu Asn Asn His Met Arg Thr His Ser Ala Lys Lys Pro Phe 
    450                 455                 460                 


Thr Cys Met Glu Cys Gly Lys Ala Phe Lys Phe Pro Thr Cys Val Asn 
465                 470                 475                 480 


Leu His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln 
                485                 490                 495     


Cys Gly Lys Ser Phe Ser Tyr Ser Asn Ser Phe Gln Leu His Glu Arg 
            500                 505                 510         


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala 
        515                 520                 525             


Phe Ser Ser Ser Ser Ser Phe Arg Asn His Glu Arg Arg His Ala Asp 
    530                 535                 540                 


Glu Arg Leu Ser Ala 
545                 


<210>  1274
<211>  2757
<212>  DNA
<213>  homo sapiens

<400>  1274
atgccagggg gcgcaggcgc cgcccggctc tgcttgctgg cgtttgccct gcagcccctc       60

cggccgcggg cggcgcggga gcctggatgg acaagaggaa gtgaggaagg cagccccaag      120

ctgcagcatg aacttatcat acctcagtgg aagacttcag aaagccccgt gagagaaaag      180

catccactca aagctgagct cagggtaatg gctgaggggc gagaactgat cctggacctg      240

gagaagaatg agcaactttt tgctccttcc tacacagaaa cccattatac ttcaagtggt      300

aaccctcaaa ccaccacacg gaaattggag gatcactgct tttaccacgg cacggtgagg      360

gagacagaac tgtccagcgt cacgctcagc acttgccgag gaattagagg actgattacg      420

gtgagcagca acctcagcta cgtcatcgag cccctccctg acagcaaggg ccaacacctt      480

atttacagat ctgaacatct caagccgccc ccgggaaact gtgggttcga gcactccaag      540

cccaccacca gggactgggc tcttcagttt acacaacaga ccaagaagcg acctcgcagg      600

atgaaaaggg aagatttaaa ctccatgaag tatgtggagc tttacctcgt ggctgattat      660

ttagagtttc agaagaatcg acgagaccag gacgccacca aacacaagct catagagatc      720

gccaactatg ttgataagtt ttaccgatcc ttgaacatcc ggattgctct cgtgggcttg      780

gaagtgtgga cccacgggaa catgtgtgaa gtttcagaga atccatattc taccctctgg      840

tcctttctca gttggaggcg caagctgctt gcccagaagt accatgacaa cgcccaatta      900

atcacgggca tgtccttcca cggcaccacc atcggcctgg cccccctcat ggccatgtgc      960

tctgtgtacc agtctggagg agtcaacatg gaccactccg agaatgccat tggcgtggct     1020

gccaccatgg cccacgagat gggccacaac tttggcatga cccatgattc tgcagattgc     1080

tgctcggcca gtgcggctga tggtgggtgc atcatggcag ctgccactgg gcaccccttt     1140

cccaaagtgt tcaatggatg caacaggagg gagctggaca ggtatctgca gtcaggtggt     1200

ggaatgtgtc tctccaacat gccagacacc aggatgttgt atggaggccg gaggtgtggg     1260

aacgggtatc tggaagatgg ggaagagtgt gactgtggag aagaagagga atgtaacaac     1320

ccctgctgca atgcctctaa ttgtaccctg aggccggggg cggagtgtgc tcacggctcc     1380

tgctgccacc agtgtaagct gttggctcct gggaccctgt gccgcgagca ggccaggcag     1440

tgtgacctcc cggagttctg tacgggcaag tctccccact gccctaccaa cttctaccag     1500

atggatggta ccccctgtga gggcggccag gcctactgct acaacggcat gtgcctcacc     1560

taccaggagc agtgccagca gctgtgggga cccggagccc gacctgcccc tgacctctgc     1620

ttcgagaagg tgaatgtggc aggagacacc tttggaaact gtggaaagga catgaatggt     1680

gaacacagga agtgcaacat gagagatgcg aagtgtggga agatccagtg tcagagctct     1740

gaggcccggc ccctggagtc caacgcggtg cccattgaca ccactatcat catgaatggg     1800

aggcagatcc agtgccgggg cacccacgtc taccgaggtc ctgaggagga gggtgacatg     1860

ctggacccag ggctggtgat gactggaacc aagtgtggct acaaccatat ttgctttgag     1920

gggcagtgca ggaacacctc cttctttgaa actgaaggct gtgggaagaa gtgcaatggc     1980

catggggtct gtaacaacaa ccagaactgc cactgcctgc cgggctgggc cccgcccttc     2040

tgcaacacac cgggccacgg gggcagtatc gacagtgggc ctatgccccc tgagagtgtg     2100

ggtcctgtgg tagctggagt gttggtggcc atcttggtgc tggcggtcct catgctgatg     2160

tactactgct gcagacagaa caacaaacta ggccaactca agccctcagc tctcccttcc     2220

aagctgaggc aacagttcag ttgtcccttc agggtttctc agaacagcgg gactggtcat     2280

gccaacccaa ctttcaagct gcagacgccc cagggcaagc gaaaggtgat caacactccg     2340

gaaatcctgc ggaagccctc ccagcctcct ccccggcccc ctccagatta tctgcgtggt     2400

gggtccccac ctgcaccact gccagctcac ctgagcaggg ctgctaggaa ctccccaggg     2460

cccgggtctc aaatagagag gacggagtcg tccaggaggc ctcctccaag ccggccaatt     2520

ccccccgcac caaattgcat cgtttcccag gacttctcca ggcctcggcc gccccagaag     2580

gcactcccgg caaacccagt gccaggccgc aggagcctcc ccaggccagg aggtgcatcc     2640

ccactgcggc cccctggtgc tggccctcag cagtcccggc ctctggcagc acttgcccca     2700

aagtttccag aatacagatc acagagggct ggagggatga ttagctcgaa aatctag        2757


<210>  1275
<211>  2067
<212>  DNA
<213>  homo sapiens

<400>  1275
atggcggacc tggaggctgt gctggccgat gtcagttacc tgatggccat ggagaagagc       60

aaggcgaccc cggccgcccg cgccagcaag aggatcgtcc tgccggagcc cagtatccgg      120

agtgtgatgc agaagtacct tgcagagaga aatgaaataa cctttgacaa gattttcaat      180

cagaaaattg gtttcttgct atttaaagat ttttgtttga atgaaattaa tgaagctgta      240

cctcaggtga agttttatga agagataaag gaatatgaaa aacttgataa tgaggaagac      300

cgcctttgca gaagtcgaca aatttatgat gcctacatca tgaaggaact tctttcctgt      360

tcacatcctt tctcaaagca agctgtagaa cacgtacaaa gtcatttatc caagaaacaa      420

gtgacatcaa ctctttttca gccatacata gaagaaattt gtgaaagcct tcgaggtgac      480

atttttcaaa aatttatgga aagtgacaag ttcactagat tttgtcagtg gaaaaacgtt      540

gaattaaata tccatttgac catgaatgag ttcagtgtgc ataggattat tggacgagga      600

ggattcgggg aagtttatgg ttgcaggaaa gcagacactg gaaaaatgta tgcaatgaaa      660

tgcttagata agaagaggat caaaatgaaa caaggagaaa cattagcctt aaatgaaaga      720

atcatgttgt ctcttgtcag cacaggagac tgtcctttca ttgtatgtat gacctatgcc      780

ttccataccc cagataaact ctgcttcatc ctggatctga tgaacggggg cgatttgcac      840

taccaccttt cacaacacgg tgtgttctct gagaaggaga tgcggtttta tgccactgaa      900

atcattctgg gtctggaaca catgcacaat cggtttgttg tctacagaga tttgaagcca      960

gcaaatattc tcttggatga acatggacac gcaagaatat cagatcttgg tcttgcctgc     1020

gatttttcca aaaagaagcc tcatgcgagt gttggcaccc atgggtacat ggctcccgag     1080

gtgctgcaga aggggacggc ctatgacagc agtgccgact ggttctccct gggctgcatg     1140

cttttcaaac ttctgagagg tcacagccct ttcagacaac ataaaaccaa agacaagcat     1200

gaaattgacc gaatgacact caccgtgaat gtggaacttc cagacacctt ctctcctgaa     1260

ctgaagtccc ttttggaggg cttgcttcag cgagacgtta gcaagcggct gggctgtcac     1320

ggaggcggct cacaggaagt aaaagagcac agctttttca aaggtgttga ctggcagcat     1380

gtctacttac aaaagtaccc accacccttg attcctcccc ggggagaagt caatgctgct     1440

gatgcctttg atattggctc atttgatgaa gaggatacca aagggattaa gctacttgat     1500

tgcgaccaag aactctacaa gaacttccct ttggtcatct ctgaacgctg gcagcaagaa     1560

gtaacggaaa cagtttatga agcagtaaat gcagacacag ataaaatcga ggccaggaag     1620

agagctaaaa ataagcaact tggccacgaa gaagattacg ctctggggaa ggactgtatt     1680

atgcacgggt acatgctgaa actgggaaac ccatttctga ctcagtggca gcgtcgctat     1740

ttttacctct ttccaaatag acttgaatgg agaggagagg gagagtcccg gcaaaattta     1800

ctgacaatgg aacagattct ctctgtggaa gaaactcaaa ttaaagacaa aaaatgcatt     1860

ttgttcagaa taaaaggagg gaaacaattt gtcttgcaat gtgagagtga tccagagttt     1920

gtgcagtgga agaaagagtt gaacgaaacc ttcaaggagg cccagcggct attgcgtcgt     1980

gccccgaagt tcctcaacaa acctcggtca ggtactgtgg agctcccaaa gccatccctc     2040

tgtcacagaa acagcaacgg cctctag                                         2067


<210>  1276
<211>  1455
<212>  DNA
<213>  homo sapiens

<400>  1276
atggcggctg gaggcgatca tggttcgccc gacagctacc gctcacctct tgcctcccgc       60

tatgccagcc cggagatgtg cttcgtgttt agcgacaggt ataaattccg gacatggcgg      120

cagctgtggc tgtggctggc ggaggccgag cagacattgg gtttgcctat cacagatgaa      180

caaatccagg agatgaaatc aaacctggag aacatcgact tcaagatggc agctgaggaa      240

gagaaacgtt tacgacatga tgtgatggct cacgtgcaca catttggcca ctgctgtcca      300

aaagctgcag gcattattca ccttggtgct acttcttgct atgttggaga caatactgac      360

ttgattattc ttagaaatgc acttgacctg cttttgccaa agcttgccag agtgatctct      420

cggcttgccg actttgctaa ggaacgagcc agtctaccca cattaggttt cacacatttc      480

cagcctgcac agctgaccac agttgggaaa cgttgctgtc tttggattca ggatctttgc      540

atggatctcc agaacttgaa gcgtgtccga gatgacctgc gcttccgggg agtaaagggt      600

accactggca ctcaggccag tttcctgcag ctctttgagg gagatgacca taaggtagag      660

cagcttgaca agatggtgac agaaaaggca ggatttaaga gagctttcat catcacaggg      720

cagacatata cacgaaaagt ggatattgaa gtactgtctg tgctggctag cttgggggca      780

tcagtgcaca agatttgcac cgacatacgc ctcctggcaa acctcaagga gatggaggaa      840

ccctttgaaa aacagcagat tggctcaagt gcgatgccat ataagcggaa tcccatgcgt      900

tcagaacgtt gctgcagtct tgcccgccac ctgatgaccc ttgtcatgga cccgctacag      960

acagcatctg tccagtggtt tgaacgcaca ctggatgata gtgccaaccg acggatctgt     1020

ttggccgagg catttcttac cgcagatact atattgaata cgctgcagaa catttctgaa     1080

ggattggtcg tgtaccccaa agtaattgaa cggcgcattc ggcaagagct gcctttcatg     1140

gccacagaga acatcatcat ggccatggtc aaagctggag gtagccgcca ggattgccat     1200

gagaaaatca gagtgctttc tcagcaggca gcttctgtgg ttaagcagga agggggtgac     1260

aatgacctca tagagcgtat ccaggttgat gcctacttca gtcccattca ctcccagttg     1320

gatcatttac tggatccttc ttctttcact ggtcgtgcct cccagcaggt gcagagattc     1380

ttagaagagg aggtgtatcc cctgttaaaa ccatatgaaa gcgtgatgaa ggtgaaagca     1440

gaattatgtc tgtag                                                      1455


<210>  1277
<211>  1041
<212>  DNA
<213>  homo sapiens

<400>  1277
atggcgcgga agtcgaactt gcctgtgctt ctcgtgccgt ttctgctctg ccaggcccta       60

gtgcgctgct ccagccctct gcccctggtc gtcaacactt ggccctttaa gaatgcaacc      120

gaagcagcgt ggagggcatt agcatctgga ggctctgccc tggatgcagt ggagagcggc      180

tgtgccatgt gtgagagaga gcagtgtgac ggctctgtag gctttggagg aagtcctgat      240

gaacttggag aaaccacact agatgccatg atcatggatg gcactactat ggatgtagga      300

gcagtaggag atctcagacg aattaaaaat gctattggtg tggcacggaa agtactggaa      360

catacaacac acacactttt agtaggagag tcagccacca catttgctca aagtatgggg      420

tttatcaatg aagacttatc taccactgct tctcaagctc ttcattcaga ttggcttgct      480

cggaattgcc agccaaatta ttggaggaat gttataccag atccctcaaa atactgcgga      540

ccctacaaac cacctggtat cttaaagcag gatattccta tccataaaga aacagaagat      600

gatcgtggtc atgacactat tggcatggtt gtaatccata agacaggaca tattgctgct      660

ggtacatcta caaatggtat aaaattcaaa atacatggcc gtgtaggaga ctcaccaata      720

cctggagctg gagcctatgc tgacgatact gcaggggcag ccgcagccac tgggaatggt      780

gatatattga tgcgcttcct gccaagctac caagctgtag aatacatgag aagaggagaa      840

gatccaacca tagcttgcca aaaagtgatt tcaagaatcc agaagcattt tccagaattc      900

tttggggctg ttatatgtgc caatgtgact ggaagttacg gtgctgcttg caataaactt      960

tcaacattta ctcagtttag tttcatggtt tataattccg aaaaaaatca gccaactgag     1020

gaaaaagtgg actgcatcta a                                               1041


<210>  1278
<211>  1095
<212>  DNA
<213>  homo sapiens

<400>  1278
atgctgctgt ccctggtgct ccacacgtac tccatgcgct acctgctgcc cagcgtcgtg       60

ctcctgggca cggcgcccac ctacgtgttg gcctgggggg tctggcggct gctctccgcc      120

ttcctgcccg cccgcttcta ccaagcgctg gacgaccggc tctactgcgt ctaccagagc      180

atggtgctct tcttcttcga gaattacacc ggggtccaga tattgctata tggagatttg      240

ccaaaaaata aagaaaatat aatatattta gcaaatcatc aaagcacagt tgactggatt      300

gttgctgaca tcttggccat caggcagaat gcgctaggac atgtgcgcta cgtgctgaaa      360

gaagggttaa aatggctgcc attgtatggg tgttactttg ctcagcatgg aggaatctat      420

gtaaagcgca gtgccaaatt taacgagaaa gagatgcgaa acaagttgca gagctacgtg      480

gacgcaggaa ctccaatgta tcttgtgatt tttccagaag gtacaaggta taatccagag      540

caaacaaaag tcctttcagc tagtcaggca tttgctgccc aacgtggcct tgcagtatta      600

aaacatgtgc taacaccacg aataaaggca actcacgttg cttttgattg catgaagaat      660

tatttagatg caatttatga tgttacggtg gtttatgaag ggaaagacga tggagggcag      720

cgaagagagt caccgaccat gacggaattt ctctgcaaag aatgtccaaa aattcatatt      780

cacattgatc gtatcgacaa aaaagatgtc ccagaagaac aagaacatat gagaagatgg      840

ctgcatgaac gtttcgaaat caaagataag atgcttatag aattttatga gtcaccagat      900

ccagaaagaa gaaaaagatt tcctgggaaa agtgttaatt ccaaattaag tatcaagaag      960

actttaccat caatgttgat cttaagtggt ttgactgcag gcatgcttat gaccgatgct     1020

ggaaggaagc tgtatgtgaa cacctggata tatggaaccc tacttggctg cctgtgggtt     1080

actattaaag catag                                                      1095


<210>  1279
<211>  3006
<212>  DNA
<213>  homo sapiens

<400>  1279
atggctttac cgcagagtga agatgcaatg accggggaca cagacaaata tcttgggcca       60

caggacctta aggaattggg tgatgattcc ctgcctgcag agggttacat gggctttagt      120

ctcggagcgc gttctgccag cctccgctcc ttcagttcgg ataggtctta caccttgaac      180

agaagctcct atgcacggga cagcatgatg attgaagaac tccttgtgcc atccaaagag      240

cagcatctaa cattcacaag ggaatttgat tcagattctc ttagacatta cagctgggct      300

gcagacacct tagacaatgt caatcttgtt tcaagcccca ttcattctgg gtttctggtt      360

agctttatgg tggacgcgag agggggctcc atgagaggaa gccgtcatca cgggatgaga      420

atcatcattc ctccacgcaa gtgtacggcc cccactcgaa tcacctgccg tttggtaaag      480

agacataaac tggccaaccc accccccatg gtggaaggag agggattagc cagtaggctg      540

gtagaaatgg gtcctgcagg ggcacaattt ttaggccctg tcatagtgga aatccctcac      600

tttgggtcca tgagaggaaa agagagagaa ctcattgttc ttcgaagtga aaatggtgaa      660

acttggaagg agcatcagtt tgacagcaaa aatgaagatt taaccgagtt acttaatggc      720

atggatgaag aacttgatag cccagaagag ttagggaaaa agcgtatctg caggattatc      780

acgaaagatt tcccccagta ttttgcagtg gtttcccgga ttaagcagga aagcaaccag      840

attggtcctg aaggtggaat tctgagcagc accacagtgc cccttgttca agcatctttc      900

ccagagggtg ccctaactaa aagaattcga gtgggcctcc aggcccagcc tgttccagat      960

gaaattgtga aaaagatcct tggaaacaaa gcaactttta gcccaattgt cactgtggaa     1020

ccaagaagac ggaaattcca taaaccaatc acaatgacca ttccggtgcc cccgccctca     1080

ggagaaggtg tatccaatgg atacaaaggg gacactacac ccaatctgcg tcttctctgt     1140

agcattacag ggggcacttc gcctgctcag tgggaagaca tcacaggaac aactcctttg     1200

acgtttataa aagattgtgt ctcctttaca accaatgttt cagccagatt ttggcttgca     1260

gactgccatc aagttttaga aactgtgggg ttagccacgc aactgtacag agaattgata     1320

tgtgttccat atatggccaa gtttgttgtt tttgccaaaa tgaatgatcc cgtagaatct     1380

tccttgcgat gtttctgcat gacagatgac aaagtggaca aaactttaga gcaacaagag     1440

aattttgagg aagtcgcaag aagcaaagat attgaggttc tggaaggaaa acctatttat     1500

gttgattgtt atggaaattt ggccccactt accaaaggag gacagcaact tgtttttaac     1560

ttttattctt tcaaagaaaa tagactgcca ttttccatca agattagaga caccagccaa     1620

gagccctgtg gtcgtctgtc ttttctgaaa gaaccaaaga caacaaaagg actgcctcaa     1680

acagcggttt gcaacttaaa tatcactctg ccagcacata aaaagattga gaaaacagat     1740

agacgacaga gcttcgcatc cttagcttta cgtaagcgct acagctactt gactgagcct     1800

ggaatgagtc cacagagtcc atgtgaacgg acagatatca ggatggcaat agtagccgat     1860

cacctgggac ttagttggac agaactggca agggaactga atttttcagt ggatgaaatc     1920

aatcaaatac gtgtggaaaa tccaaattct ttaatttctc agagcttcat gttattaaaa     1980

aaatgggtta ccagagacgg aaaaaatgcc acaactgatg ccttaacttc ggtcttgaca     2040

aaaattaatc gaatagatat agtgacactg ctagaaggac caatatttga ttatggaaat     2100

atttcaggca ccagaagttt tgcagatgag aacaatgttt tccatgaccc tgttgatggt     2160

tatccttccc ttcaagtgga actggaaacc cccacagggt tgcactacac accacctacc     2220

cctttccagc aagatgatta ttttagtgat atctctagca tagaatctcc ccttagaacc     2280

cctagtagac tgagtgatgg gctagtgcct tcccagggga acatagagca ttccgcagat     2340

ggacctccag tcgtaactgc agaagacgct tccttagaag acagcaaact ggaagactca     2400

gtgcctttaa cagaaatgcc tgaagcagtg gatgtagatg agagccagtt ggagaatgta     2460

tgtctgagtt ggcagaatga gacatcaagt ggaaacctag agtcctgcgc tcaagctcga     2520

agagtaactg gtgggttact agatcgactg gatgacagcc ctgaccagtg tagagattcc     2580

attacctcat atctcaaagg agaagctggc aaatttgaag caaatggaag ccatacagaa     2640

atcactccag aagcaaagac aaaatcttac tttccagaat cccaaaatga tgtaggaaaa     2700

cagagtacca aggaaactct gaaaccaaaa atacatggat ctggtcatgt tgaagaacca     2760

gcatcaccac tagcagcata tcagaaatct ctagaagaaa ccagcaagct tataatagaa     2820

gagactaaac cctgtgtgcc tgtcagtatg aaaaagatga gtaggacttc tccagcagat     2880

ggcaagccaa ggcttagcct ccatgaagaa gaggggtcca gtgggtctga gcaaaagcag     2940

ggagaaggtt ttaaggtgaa aacgaagaaa gaaatccggc atgtggaaaa gaagagccac     3000

tcgtaa                                                                3006


<210>  1280
<211>  4506
<212>  DNA
<213>  homo sapiens

<400>  1280
atgatggcaa aaaacaaaga gcctcgtccc ccatcctata ccatcagtat agttggactc       60

tctgggactg aaaaagacaa aggtaactgt ggagttggaa agtcttgttt gtgcaataga      120

tttgtacgct caaaagcaga tgaatattat ccagagcata cttctgtgct tagcaccatt      180

gactttggag gacgagtagt aaacaatgat cactttttgt actggggtga cataatacaa      240

aatagtgaag atggagtaga atgcaaaatt catgtcattg aacaaacaga gttcattgat      300

gaccagactt tcttgcctca tcggagtacg aatttgcaac catatataaa acgtgcagct      360

gcatctaaat tgcagtcagc agaaaaacta atgtacattt gcactgatca gctaggctta      420

gaacaagact ttgaacagaa gcaaatgcct gaagggaagc tcaacgtaga tggattttta      480

ttatgcattg atgtaagtca aggatgcaat aggaagtttg atgatcaact taaatttgtg      540

aataaccttt ttgtccagtt atcaaaatca aaaaaacctg taataatagc agcaactaaa      600

tgtgatgaat gcgtggatca ttatcttaga gaagttcagg catttgcttc aaataaaaag      660

aaccttcttg tagtggaaac atcagcacga tttaatgtca acattgaaac atgttttact      720

gcactggtac aaatgttgga taaaactcgt agcaagccta aaattattcc ctatttggat      780

gcttataaaa cacagagaca acttgttgtc acagcaacag ataagtttga aaaacttgtg      840

cagactgtga gagattatca tgcaacttgg aaaactgtta gtaataaatt aaaaaatcat      900

cctgattatg aagaatacat caacttagag ggaacaagaa aggccagaaa tacattctca      960

aaacatatag aacaacttaa acaggaacat ataagaaaaa ggagagaaga gtatataaat     1020

actttaccaa gagcttttaa cactcttttg ccaaatctag aagagattga acatttgaat     1080

tggtcagaag ctttgaagtt aatggaaaag agagcagatt tccagttatg ttttgtggtg     1140

ctagaaaaaa ctccttggga tgaaactgac catatagaca aaattaatga taggcggatt     1200

ccatttgacc tcctgagcac tttagaagct gaaaaagtct atcagaacca tgtacagcat     1260

ctgatatccg agaagaggag ggtggaaatg aaggaaaaat tcaaaaagac tttggaaaaa     1320

attcaattca tttcaccagg gcagccatgg gaggaagtta tgtgctttgt tatggaggat     1380

gaagcctaca aatatatcac tgaggctgat agcaaagagg tatatggtag gcatcagcga     1440

gaaatagttg aaaaagccaa agaagagttt caagaaatgc tttttgagca ttctgaactt     1500

ttttatgatt tagatcttaa tgcaacacct agttcagata aaatgagtga aattcataca     1560

gttctgagtg aagaacctag atataaagct ttacagaaac ttgcacctga tagggaatcc     1620

cttctactta agcatatagg atttgtttat catcccacta aagaaacatg tcttagtggc     1680

caaaattgta cagacattaa agtggagcag ttacttgcta gtagtctttt acagttggat     1740

catggccgct taagattata tcacgatagt accaatatag ataaagttaa cctttttatt     1800

ttagggaagg atggccttgc ccaagaacta gcaaatgaga taaggacaca atccactgat     1860

gatgagtatg ccttagatgg aaaaatttat gaacttgatc ttcggccggt tgatgccaaa     1920

tcgccttact ttttgagtca gttatggact gccgccttta aaccacatgg gtgcttctgt     1980

gtatttaatt ccattgagtc attgagtttt attggggaat ttattgggaa aataagaact     2040

gaagcttctc agatcagaaa agataaatac atggctaatc ttccatttac attaattctg     2100

gctaatcaga gagattccat tagtaagaat ctaccaattc tcaggcacca agggcagcag     2160

ttggcaaaca agttgcaatg tccttttgta gatgtacctg ctggtacata tcctcgtaaa     2220

tttaatgaaa cccaaataaa gcaagctctc agaggagtat tggaatcagt taaacacaat     2280

ttggatgtgg tgagcccaat tcctgccaat aaggacttat cagaagctga cttgagaatt     2340

gtcatgtgcg ccatgtgtgg agatccattt agtgtggatc ttattctttc acccttcctt     2400

gattctcatt cttgcagtgc tgctcaagct ggacagaata attccctaat gcttgataaa     2460

atcattggtg aaaaaaggag gcgaatacag atcacaatat tatcatacca ctcttcaatt     2520

ggagtaagaa aagatgaact agttcatggg tatatattag tttactctgc aaaacggaaa     2580

gcttcgatgg gaatgcttcg agcatttcta tcagaagttc aagacaccat tcctgtacag     2640

ctggtggcag ttactgacag ccaagcagat ttttttgaaa atgaggctat caaagagtta     2700

atgactgaag gagaacacat tgcaactgag atcactgcta aatttacagc actgtattct     2760

ttatctcagt atcatcggca aactgaggtc tttactctgt tttttagtga tgttctagag     2820

aaaaaaaata tgatagaaaa ttcttatttg tctgataata caagggaatc aacccatcaa     2880

agtgaagatg tttttctacc atctcccaga gactgttttc cctataataa ctaccctgat     2940

tcagatgatg acacagaagc accacctcct tatagtccaa ttggggatga tgtacagttg     3000

cttccaacac ctagtgaccg ttccagatat agattagatt tggaaggaaa tgagtatcct     3060

attcatagta ccccaaactg tcatgaccat gaacgcaacc ataaagtgcc tccacctatt     3120

aaacctaaac cagttgtacc taagacaaat gtgaaaaaac tcgatccaaa ccttttaaaa     3180

acaattgaag ctggtattgg taaaaatcca agaaagcaga cttcccgggt gcctttggca     3240

catcctgaag atatggatcc ttcagataac tatgcggaac ccattgatac aattttcaaa     3300

cagaagggct attctgatga gatttatgtt gtcccagatg atagtcaaaa tcgtattaaa     3360

attcgaaact catttgtaaa taacacccaa ggagatgaag aaaatgggtt ttctgataga     3420

acctcaaaaa gtcatgggga acggaggcct tcaaaataca aatataaatc taaaaccttg     3480

tttagtaaag ccaagtcata ctatagaaga acacattcag atgccagtga tgatgaggct     3540

ttcaccactt ctaaaacaaa aagaaaagga agacatcgtg gaagtgaaga agatccactt     3600

ctttctcctg ttgaaacttg gaaaggtggt attgataatc ctgcaatcac ttctgaccag     3660

gagttagatg ataagaagat gaagaagaaa acccacaaag tgaaagaaga taaaaagaaa     3720

aagaaaacta agaacttcaa tccaccaaca cgtagaaatt gggaaagtaa ttactttggg     3780

atgcccctcc aggatctggt tacagctgag aagcccatac cactatttgt tgagaaatgt     3840

gtggaattta ttgaagatac agggttatgt accgaaggac tctaccgtgt cagcgggaat     3900

aaaactgacc aagacaatat tcaaaagcag tttgatcaag atcataatat caatctagtg     3960

tcaatggaag taacagtaaa tgctgtagct ggagccctta aagctttctt tgcagatctg     4020

ccagatcctt taattccata ttctcttcat ccagaactat tggaagcagc aaaaatcccg     4080

gataaaacag aacgtcttca tgccttgaaa gaaattgtta agaaatttca tcctgtaaac     4140

tatgatgtat tcagatacgt gataacacat ctaaacaggg ttagtcagca acataaaatc     4200

aacctaatga cagcagacaa cttatccatc tgtttttggc caaccttgat gagacctgat     4260

tttgaaaatc gagagtttct gtctactact aagattcatc aatctgttgt tgaaacattc     4320

attcagcagt gtcagttttt cttttacaat ggagaaattg tagaaacgac aaacattgtg     4380

gctcctccac caccttcaaa cccaggacag ttggtggaac caatggtgcc acttcagttg     4440

ccgccaccat tgcaacctca gctgatacaa ccacaattac aaacggatcc tcttggtatt     4500

atatga                                                                4506


<210>  1281
<211>  2331
<212>  DNA
<213>  homo sapiens

<400>  1281
atgaatccag aagaacaaat cgtgacatgg cttatatctt tgggagtttt agagtcccct       60

aaaaagacca tctgtgatcc ggaggagttt ttaaagtcct cgctgaaaaa tggggtagtt      120

ctgtgcaaac tgatcaacag actcatgcct ggctctgtgg aaaagttttg tctggatccc      180

caaactgaag ctgactgcat caacaacatc aatgacttcc tgaaaggatg tgcaaccctc      240

caagtggaaa tatttgatcc tgatgacctt tattcagggg tcaatttctc caaggtactg      300

agtactcttt tagctgtcaa caaagcaaca gaagatcagc tatcagaaag accatgtgga      360

cgttcctctt ctcttagtgc tgctaatact tctcagacaa acccacaggg agcagtttct      420

agcacagttt cagggctgca aaggcagtca aagacagtgg agatgacgga aaatggaagt      480

catcagttga tagtaaaagc aagattcaac tttaagcaga ctaatgagga tgaactgtca      540

gtttgtaagg gggacatcat ttacgtcaca cgagttgaag aaggaggctg gtgggaaggc      600

acattaaatg ggagaacagg ctggttcccc agtaattatg tccgtgaaat taaatccagt      660

gagagacctc tctccccaaa agccgtcaaa ggatttgaaa ctgctccact taccaagaat      720

tattatactg tggtgttaca gaacatcctg gacactgaaa aagaatatgc taaagaactt      780

cagtctcttc ttgttactta cttaagaccc ctgcagtcca ataacaatct gagtactgtg      840

gaggttacat ctttactggg aaacttcgag gaagtatgca catttcaaca gacactctgc      900

caagccttgg aagaatgttc aaagtttcca gaaaaccagc acaaagtagg aggttgtcta      960

ctgagtctca tgcctcattt taaatctatg tatctggctt actgtgcaaa ccatccttca     1020

gctgtaaatg tgctcactca gcacagtgat gagttggaac aattcatgga aaatcaaggt     1080

gcatcgagcc caggtatcct cattttaaca acaaacctca gcaaaccatt catgcgactg     1140

gagaaatatg ttactctctt gcaagagtta gaacggcata tggaggatac tcatccagat     1200

catcaggata ttctgaaagc aatcgtagca ttcaaaactc tcatggggca atgtcaagat     1260

ctgaggaaga gaaaacagct ggagttacag atactgtccg aacctattca ggcatgggaa     1320

ggagaagata ttaaaaactt gggaaatgtg atttttatgt cacaagtaat ggtgcagtat     1380

ggagcatgtg aggaaaaaga ggagcggtac cttatgttat tttcaaatgt cctgataatg     1440

ttatctgcaa gtcctcggat gagtggcttt atctatcagg gaaaaatacc aatagcagga     1500

acggtggtga ctagattaga tgaaattgaa gggaatgact gcacatttga aatcactggt     1560

aacacagtgg agagaattgt ggtccattgt aacaacaacc aggacttcca ggaatggttg     1620

gagcagctga acagactgat cagaggacct gcctcttgca gttcattatc caaaacctca     1680

tcgtcatcat gtagtgctca ttcttctttt agctctaccg gacagccccg aggacccttg     1740

gagcctcctc aaattataaa accgtggagt ttaagttgtc tacgacctgc acctccactt     1800

agaccatcag cagcactagg ttataaagag aggatgtctt atatcttaaa ggagtctagt     1860

aaaagcccta aaacgatgaa gaaatttctt cataaaagga agactgagag aaaaccatcg     1920

gaggaggaat atgtgattag gaaaagtaca gctgctctgg aagaggatgc tcaaatcctt     1980

aaagtgatcg aagcctactg caccagcgca aattttcaac aaggccatgg ctcaagtact     2040

cgaaaagatt ccattccaca agtcctactc cctgaggaag agaaactcat cattgaagaa     2100

accagaagca acggccagac catcatggaa gaaaagagcc ttgttgatac tgtttacgcc     2160

ttgaaggacg aggtcagaga actgaagcag gaaaataaaa gaatgaagca atgcctggaa     2220

gaagaactga aatcaagaag ggacctagaa aagctggtgc ggaggctttt gaagcaaaca     2280

gatgagtgta ttcgaggcga gtccagtagc aagacctcaa ttcttccata a              2331


<210>  1282
<211>  567
<212>  DNA
<213>  homo sapiens

<400>  1282
atggacgtta atatcgcccc actccgcgcc tgggacgatt tcttcccggg ttccgatcgc       60

tttgcccggc cggacttcag ggacatttcc aaatggaaca accgcgtagt gagcaacctg      120

ctctattacc agaccaacta cctggtggtg gctgccatga tgatttccat tgtggggttt      180

ctgagtccct tcaacatgat cctgggagga atcgtggtgg tgctggtgtt cacagggttt      240

gtgtgggcag cccacaataa agacgtcctt cgccggatga agaagcgcta ccccacgacg      300

ttcgttatgg tggtcatgtt ggcgagctat ttccttatct ccatgtttgg aggagtcatg      360

gtctttgtgt ttggcattac ttttcctttg ctgttgatgt ttatccatgc atcgttgaga      420

cttcggaacc tcaagaacaa actggagaat aaaatggaag gaataggttt gaagaggaca      480

ccgatgggca ttgtcctgga tgccctagaa cagcaggaag aaggcatcaa cagactcact      540

gactatatca gcaaagtgaa ggaataa                                          567


<210>  1283
<211>  6609
<212>  DNA
<213>  homo sapiens

<400>  1283
atggctttac ctcgtctcac aggagccttg cgttcctttt caaatgtcac caagcaagat       60

aattataatg aagaagtggc tgacttaaag ataaagcgat ctaaacttca tgaacaagtt      120

ttagatttgg gcctgacatg gaagaagata ataaaatttt tgaatgaaaa actggagaag      180

agtaaaatgc aaagtataaa tgaagactta aaagatatat tacatgctgc aaagcagata      240

gttggaactg ataatgggag agaagcaatt gaaagtgggg ctgcatttct cttcatgaca      300

tttcacttga aggactctgt tggtcacaag gaaacaaagg ctatcaaaca gatgtttggc      360

ccctttcctt catcatctgc cactgcagct tgtaatgcta ctaatcgaat tatttctcat      420

tttagtcaag atgatcttac tgctcttgtg cagatgacag aaaaagaaca tggcgatagg      480

gttttttttg gtaaaaattt agcattttca tttgacatgc atgatttgga ccactttgac      540

gaactgccaa taaatggtga aactcagaaa actataagcc tagattataa gaagtttctg      600

aatgaacatc tccaggaggc ttgcacccca gaactcaagc ctgtggaaaa aacaaatggc      660

tcctttttgt ggtgtgaagt tgaaaagtac ctaaattcaa ctttgaagga aatgactgaa      720

gtgccaagag tagaagatct ttgctgtact ttatatgata tgcttgcttc tattaaaagt      780

ggtgatgaac ttcaggatga gctatttgaa ctgctgggac ctgaaggact tgaacttatt      840

gagaaactcc tccagaacag aattacaatt gtggatagat ttcttaattc ttcaaatgat      900

cataggtttc aggctcttca agacaattgt aaaaaaattt taggagaaaa tgctaaaccc      960

aattatggtt gtcaagtcac tattcagtct gaacaagaaa agcagttaat gaaacaatat     1020

cgacgtgaag aaaaaagaat tgccagacga gaaaaaaagg ctggagaaga tttagaagtt     1080

tcagaaggac ttatgtgctt tgatcctaag gaattgcgga tacaaagaga acaggcactt     1140

ctgaatgcta gaagtgttcc aattctgagc aggcagagag atgcagacgt tgaaaaaata     1200

cattatcccc atgtgtatga ttcccaggct gaagccatga aaacatcagc atttattgct     1260

ggtgcaaaga tgattttgcc agaaggaatc caaagagaga ataacaagct ttatgaagaa     1320

gtaaggattc cctacagcga accaatgcca ctcagctttg aggaaaagcc agtttatatc     1380

caagacttag atgagatcgg acagctggct tttaaaggaa tgaagagact caatagaatc     1440

cagtcaatag tgtttgagac tgcctacaac accaatgaga acatgctgat ttgtgcccct     1500

acaggagctg gaaaaaccaa cattgcaatg ctgacagtct tgcatgaaat tcgccaacat     1560

tttcaacaag gtgttatcaa aaagaatgaa tttaagattg tatatgttgc tccaatgaaa     1620

gccttggcag ctgaaatgac agattacttc agcagacgtc tagagccact aggcatcatt     1680

gtgaaagaat tgactggtga catgcagttg tccaaaagtg aaattttacg aactcagatg     1740

cttgtgacca caccagaaaa atgggatgta gtgacaagaa agagtgttgg ggatgtagct     1800

ctttcccaga ttgtaaggct ccttattctt gatgaagttc atttgctgca tgaagataga     1860

ggaccagtat tagaaagcat agttgcccgt actttacggc aggtggaatc cacacagagt     1920

atgataagga ttctcggact gtctgcaact ttacctaact acctcgatgt tgccacattt     1980

ttacatgtta atccatacat tggacttttc ttctttgatg gccgttttcg accagtacct     2040

cttggacaga catttttggg gattaaatgt gcaaataaga tgcagcagtt gaataacatg     2100

gatgaagtat gttatgaaaa tgttttgaag caagtaaagg ctggacacca ggtgatggtg     2160

tttgtacatg ctcgaaatgc cactgtaaga acagctatgt ctctaataga aagagcaaaa     2220

aattgtggcc atattccctt cttttttcct acccaaggac atgactatgt acttgcagaa     2280

aaacaggtac aaaggtcgag aaataagcaa gtacgagaat tattcccaga tggttttagt     2340

attcatcatg caggaatgct tcggcaggac agaaatttag ttgaaaactt gttttctaat     2400

gggcatatca aagtcctagt gtgtacagct acgttagcct ggggtgtcaa tcttcccgcc     2460

catgctgtta ttattaaggg aacacaaata tatgctgcaa aaagaggctc ctttgttgac     2520

cttggaattt tagatgtcat gcagatattt ggtcgagctg gacgaccaca atttgacaaa     2580

tttggggaag gaataattat aacaacgcat gataaactca gccattacct cactttgctc     2640

actcaacgaa acccaattga gagtcagttt ctggaaagcc ttgcagataa cctaaatgca     2700

gagattgctc tgggaacagt tactaatgtg gaagaagcag tgaagtggat aagttacact     2760

tatctttatg tacggatgag agcaaatcca ttagcatatg gcatcagtca caaggcttat     2820

cagattgacc caacattaag aaagcatcga gaacagttgg tcattgaagt tggacgaaaa     2880

ctagacaaag ctcagatgat tcgttttgag gagcgaactg gatatttttc ctcaactgat     2940

ttgggtagaa ctgccagcca ttactatatt aaatacaaca ccattgagac ctttaatgaa     3000

ctctttgatg ctcacaaaac agaaggtgat atctttgcca tagtctccaa agctgaagaa     3060

tttgatcaaa ttaaggtcag agaagaggaa atagaggagt tagatacctt attaagcaat     3120

ttttgtgaac tctccactcc tggaggtgta gagaatagtt atgggaaaat aaacatctta     3180

cttcaaactt atatcagccg aggagaaatg gacagtttct cccttatatc agattctgca     3240

tatgttgcac agaatgcagc tagaattgtc cgtgctcttt ttgaaattgc tctgaggaaa     3300

cgttggccta ccatgaccta caggctcctg aatcttagta aagtcattga caagaggctt     3360

tggggttggg ctagcccttt gagacaattt tcaatcctac caccacacat cctaacaaga     3420

ttagaagaaa aaaagcttac tgtggataag ctgaaagaca tgaggaaaga tgaaataggt     3480

cacattttac atcatgtgaa tattggactg aaggtcaaac aatgtgttca tcagattcct     3540

tctgttatga tggaagcatc cattcagcct atcacaagga ctgtcctccg agtgacactc     3600

agcatctatg ctgatttcac ttggaatgat caggtacatg ggacagtagg agaaccttgg     3660

tggatttggg tagaagatcc tacaaatgat catatttatc attcagagta ttttctagct     3720

ctaaaaaaac aagtcattag taaagaagcc caactactgg tatttacaat ccctattttt     3780

gagcctttgc cttcccaata ctacatccga gcagtgtctg atagatggtt gggtgctgag     3840

gcagtatgta ttatcaactt tcaacatcta attctaccag agagacatcc tcctcataca     3900

gaattactgg atcttcagcc tttaccaatc acagctttgg gatgtaaagc atatgaagcc     3960

ctgtacaact tcagccactt taaccctgta cagacacaaa tatttcatac attgtatcac     4020

acggattgta atgtcctact tggagcacct actggatcgg gaaagactgt tgcagctgaa     4080

ttagccattt tcagagtctt caacaaatac cctacttcaa aggcggtata tattgcaccc     4140

ctaaaagccc tagtacgtga aagaatggat gattggaaag ttagaataga agaaaaactt     4200

ggtaaaaaag ttattgaact aacaggggat gtgactcctg atatgaaatc cattgccaag     4260

gctgacctta tcgtcactac gccagagaag tgggatggag tcagcagaag ctggcaaaat     4320

aggaactatg ttcagcaagt cactattctc atcatagatg agatccatct gcttggggag     4380

gaaagaggcc ctgttctaga ggtcattgta tctcgaacaa attttatctc atcacacaca     4440

gaaaagcctg ttagaatagt tggactatct actgcattag ctaatgccag agaccttgct     4500

gattggctca atattaagca gatgggcttg tttaacttcc gaccatcagt acgcccagtt     4560

ccactggaag ttcacattca aggctttcca ggtcaacatt actgtcctcg tatggctagt     4620

atgaacaagc ctgcatttca ggcaattaga agccattctc cagccaaacc tgttttgata     4680

tttgtctcat caagacgtca aactcgtctt actgctttgg aattgatcgc cttcctggct     4740

actgaagaag atccaaagca gtggttaaac atggatgaaa gagagatgga gaacatcatt     4800

gcaacagtaa gagattccaa cctcaagctg acccttgctt tcgggatagg aatgcatcat     4860

gctggactac atgagaggga ccgaaaaaca gtagaggaac tatttgtaaa ctgtaaagtt     4920

caggttctta ttgctacaag cacattagcc tggggtgtaa actttccagc tcatttagta     4980

attattaagg gaacagaata ctatgatgga aaaacaagac gttatgtgga ttttcccatt     5040

acagatgtcc tccagatgat ggggcgtgct gggaggccgc agttcgatga ccaaggcaaa     5100

gctgtaattc tagttcatga cataaagaaa gacttttata aaaaatttct ttatgaacct     5160

ttcccagtag aatcaagttt attaggagtg ctctctgacc acttaaatgc agagattgct     5220

ggtggtacaa ttacatctaa gcaagatgca ttggattata tcacctggac ttactttttc     5280

cgacgtctta tcatgaatcc cagctattac aatttgggtg atgtgagcca tgattctgtg     5340

aacaagtttc tgtcccatct gattgagaag tccctgattg aattggaact ttcctactgt     5400

attgaaattg gagaggataa tcgcagcatt gaacctctaa cttatggccg aattgcctcc     5460

tattactatt tgaagcatca aacagttaaa atgttcaagg accgcttgaa gcctgaatgc     5520

agtactgaag aactgctttc aattctaagt gatgcagaag aatatacaga tttgccagtg     5580

agacacaatg aagatcatat gaatagtgaa ctggcaaaat gtcttcccat tgaatcaaat     5640

cctcattcat ttgacagccc tcacaccaaa gcacatctcc tgctacaggc acatctcagc     5700

cgagccatgc taccctgccc agattatgac actgatacca aaacagtctt ggaccaagct     5760

ctcagagtat gtcaggcaat gctggacgtg gctgcaaacc agggctggct ggtgactgtc     5820

ctgaatatca ccaacctgat tcagatggtg atccagggtc ggtggttaaa ggactcttct     5880

cttcttacac taccaaacat agaaaaccat catcttcacc ttttcaagaa atggaagccg     5940

attatgaagg gcccacatgc taggggtcgg acctccatcg agtcccttcc tgaactgatc     6000

catgcctgtg gagggaaaga ccatgtattt agctccatgg tagaaagtga gctacatgct     6060

gcaaaaacga aacaggcatg gaatttctta tctcacttgc cagtgataaa tgttggcata     6120

agtgttaaag gctcgtggga tgacttagtt gaaggacata atgaactctc tgtctcaact     6180

ctgactgcag acaaacgaga tgacaacaaa tggatcaaat tgcatgctga ccaagagtat     6240

gtgcttcaag tgagcttgca gagagtccac tttgggttcc acaagggaaa gccagagagc     6300

tgtgcagtta ctcctcgatt tcccaaatca aaagacgaag gatggttttt gatattagga     6360

gaagtggata agagagaact tattgctttg aaaagagtag gatatattcg aaatcatcat     6420

gttgcttccc tttcttttta tacccctgaa atacctggaa ggtatatcta cacattatat     6480

ttcatgagtg actgctacct tggcctggac cagcagtatg acatctatct caacgttaca     6540

caagcgagtc tttctgcaca ggtcaacacc aaggtctctg attccctgac tgacctggca     6600

ttaaagtaa                                                             6609


<210>  1284
<211>  3495
<212>  DNA
<213>  homo sapiens

<400>  1284
atgcccacca tgcggaggac cgtgtcggag atccgctcgc gcgccgaagg ttatgagaag       60

acagatgatg tttcagagaa gacctcactg gctgaccagg aggaagtaag gactattttc      120

atcaaccagc cccagctgac aaaattctgc aataaccatg tcagcactgc aaaatacaac      180

ataatcacat tccttccaag atttctctac tctcagttca gaagagctgc taattcattt      240

tttctcttta ttgcactgct gcagcaaata cctgatgtgt caccaacagg tcgttataca      300

acactggttc ctctcttatt tattttagct gtggcagcta tcaaagagat aatagaagat      360

attaaacgac ataaagctga taatgcagtg aacaagaaac aaacgcaagt tttgagaaat      420

ggtgcttggg aaattgtcca ctgggaaaag gtggcagtag gggagatagt gaaagtgacc      480

aatggggaac atctcccagc agatctcatc agtctgtcct caagtgagcc ccaagccatg      540

tgctacattg aaacatccaa cttagatggt gaaacaaact tgaaaattag acagggctta      600

ccagcaacat cagatatcaa agacgttgac agtttgatga ggatttctgg cagaattgag      660

tgtgaaagtc caaacagaca tctctacgat tttgttggaa acataaggct tgatggacat      720

ggcaccgttc cactgggagc agatcagatt cttcttcgag gagctcagtt gagaaataca      780

cagtgggttc atggaatagt tgtctacact ggacatgaca ccaagctgat gcagaattca      840

acaagtccac cacttaagct ctcaaatgtg gaacggatta caaatgtaca aattttgatt      900

ttattttgta tcttaattgc catgtctctt gtctgttctg tgggctcagc catttggaat      960

cgaaggcatt ctggaaaaga ctggtatctc aatctaaact atggtggcgc tagtaatttt     1020

ggactgaatt tcttgacctt catcatcctt ttcaacaatc tcattcctat cagcttattg     1080

gttacattag aagttgtgaa atttacccag gcatacttca taaattggga tcttgacatg     1140

cactatgaac ccacagacac tgctgctatg gctcgaacat ctaatctgaa tgaggaactt     1200

ggccaggtta aatacatatt ttctgacaaa actggtactc tgacatgcaa tgtaatgcag     1260

tttaagaagt gcaccatagc gggagttgct tatggccatg tccctgaacc tgaggattat     1320

ggctgctctc ctgatgaatg gcagaactca cagtttggag atgaaaaaac atttagtgat     1380

tcatcattgc tggaaaatct ccaaaataat catccaactg cacctataat atgtgaattt     1440

cttacaatga tggcagtctg tcacacagca gtgccagagc gagaaggtga caagattatt     1500

tatcaagcag catctccaga tgagggagca ttggtcagag cagccaagca attgaatttt     1560

gttttcactg gaagaacacc cgactcggtg attatagatt cactggggca ggaagaaaga     1620

tatgaattgc tcaatgtctt ggagtttacc agtgctagga aaagaatgtc agtgattgtt     1680

cgcactccat ctggaaagtt acgactctac tgcaaaggag ctgacactgt aatttatgat     1740

cgactggcag agacgtcaaa atacaaagaa attaccctaa aacatttaga gcagtttgct     1800

acagaagggt taagaacttt atgttttgct gtggctgaga tttcagagag cgactttcag     1860

gagtggcgag cagtctatca gcgagcatct acatctgtgc agaacaggct actcaaactc     1920

gaagagagtt atgagttgat tgaaaagaat cttcagctac ttggagcaac agccattgag     1980

gataaattac aagatcaagt gcctgaaacc atagaaacgc taatgaaagc agacatcaaa     2040

atctggatcc ttacagggga caagcaagaa actgccatta acatcggaca ctcctgcaaa     2100

ctgttgaaga agaacatggg aatgattgtt ataaatgaag gctctcttga tggaacaagg     2160

gaaactctca gtcgtcactg tactaccctt ggtgatgctc tccggaaaga gaatgatttt     2220

gctcttataa ttgatgggaa aaccctcaaa tatgccttaa cctttggagt acgacagtat     2280

ttcctggact tagctttgtc atgcaaagct gtcatttgct gtcgggtttc tcctcttcaa     2340

aaatctgaag ttgttgagat ggttaagaaa caagtcaaag tcgtaacgct tgcaatcggt     2400

gatggagcaa atgatgtcag catgatacag acagcgcacg ttggtgttgg tatcagtggc     2460

aatgaaggcc tgcaggcagc taattcctct gactactcca tagctcagtt caaatatttg     2520

aagaatttac tgatgattca tggtgcctgg aactataaca gagtctccaa gtgcatctta     2580

tactgcttct acaagaatat agtgctctat attatcgaga tctggtttgc ctttgttaat     2640

ggcttttctg gacagatcct ctttgaaaga tggtgtatag gtctctataa cgtgatgttt     2700

acagcaatgc ctcctttaac tcttggaata tttgagagat catgcagaaa agagaacatg     2760

ttgaagtacc ctgaattata caaaacatct cagaatgccc tggacttcaa caccaaggtt     2820

ttctgggttc attgtttaaa tggcctcttc cactcagtta ttctgttttg gtttccacta     2880

aaagcccttc agtatggtac tgcatttgga aatgggaaaa cctcggatta tctgctactg     2940

ggaaactttg tgtacacttt tgtggtgata actgtgtgtt tgaaagctgg attggagaca     3000

tcatattgga catggttcag ccacatagcg atatggggga gcatcgcact ctgggtggtg     3060

ttttttggaa tctactcatc tctgtggcct gccattccga tggcccctga tatgtcagga     3120

gaggcagcca tgttgttcag ttctggagtc ttttggatgg gcttgttatt catccctgtg     3180

gcatctctgc tccttgatgt ggtgtacaag gttatcaaga ggactgcttt taaaacattg     3240

gtcgatgaag ttcaggagct ggaggcaaaa tctcaagacc caggagcagt tgtacttgga     3300

aaaagcctga ccgagagggc gcaactgctc aagaacgtct ttaagaagaa ccacgtgaac     3360

ttgtaccgct ctgaatcctt gcaacaaaat ctgctccatg ggtatgcgtt ctctcaagat     3420

gaaaatggaa tcgtttcaca gtctgaagtg ataagagcat atgataccac gaaacagagg     3480

cccgacgaat ggtga                                                      3495


<210>  1285
<211>  1086
<212>  DNA
<213>  homo sapiens

<400>  1285
atggagtcca tcttccacga gaaacaagaa ggctcacttt gtgctcaaca ttgcctgaat       60

aacttattgc aaggagaata ttttagccct gtggaattat cctcaattgc acatcagctg      120

gatgaggagg agaggatgag aatggcagaa ggaggagtta ctagtgaaga ttatcgcacg      180

tttttacagc agccttctgg aaatatggat gacagtggtt ttttctctat tcaggttata      240

agcaatgcct tgaaagtttg gggtttagaa ctaatcctgt tcaacagtcc agagtatcag      300

aggctcagga tcgatcctat aaatgaaaga tcatttatat gcaattataa ggaacactgg      360

tttacagtta gaaaattagg aaaacagtgg tttaacttga attctctctt gacgggtcca      420

gaattaatat cagatacata tcttgcactt ttcttggctc aattacaaca ggaaggttat      480

tctatatttg tcgttaaggg tgatctgcca gattgcgaag ctgaccaact cctgcagatg      540

attagggtcc aacagatgca tcgaccaaaa cttattggag aagaattagc acaactaaaa      600

gagcaaagag tccataaaac agacctggaa cgagtgttag aagcaaatga tggctcagga      660

atgttagacg aagatgagga ggatttgcag agggctctgg cactaagtcg ccaagaaatt      720

gacatggaag atgaggaagc agatctccgc agggctattc agctaagtat gcaaggtagt      780

tccagaaaca tatctcaaga tatgacacag acatcaggta caaatcttac ttcagaagag      840

cttcggaaga gacgagaagc ctactttgaa aaacagcagc aaaagcagca acagcagcag      900

cagcagcagc agcaggggga cctatcagga cagagttcac atccatgtga aaggccagcc      960

accagttcag gagcacttgg gagtgatcta ggtgatgcta tgagtgaaga agacatgctt     1020

caggcagctg tgaccatgtc tttagaaact gtcagaaatg atttgaaaac agaaggaaaa     1080

aaataa                                                                1086


<210>  1286
<211>  1179
<212>  DNA
<213>  homo sapiens

<400>  1286
atggcggttg tagcggcggc tgccggctgg ctactcaggc tcagggcggc aggggctgag       60

gggcactggc gtcggcttcc tggcgcgggg ctggcgcggg gctttttgca ccccgccgcg      120

actgtcgagg atgcggccca gaggcggcag gtggctcatt ttactttcca gccagatccg      180

gagccccggg agtacgggca aactcagaaa atgaatcttt tccagtctgt aacaagtgcc      240

ttggataact cattggccaa agatcctact gcagtaatat ttggtgaaga tgttgccttt      300

ggtggagtct ttagatgcac tgttggcttg cgagacaaat atggaaaaga tagagttttt      360

aataccccat tgtgtgaaca aggaattgtt ggatttggaa tcggaattgc ggtcactgga      420

gctactgcca ttgcggaaat tcagtttgca gattatattt tccctgcatt tgatcagatt      480

gttaatgaag ctgccaagta tcgctatcgc tctggggatc tttttaactg tggaagcctc      540

actatccggt ccccttgggg ctgtgttggt catggggctc tctatcattc tcagagtcct      600

gaagcatttt ttgcccattg cccaggaatc aaggtggtta tacccagaag ccctttccag      660

gccaaaggac ttcttttgtc atgcatagag gataaaaatc cttgtatatt ttttgaacct      720

aaaatacttt acagggcagc agcggaagaa gtccctatag aaccatacaa catcccactg      780

tcccaggccg aagtcataca ggaagggagt gatgttactc tagttgcctg gggcactcag      840

gttcatgtga tccgagaggt agcttccatg gcaaaagaaa agcttggagt gtcttgtgaa      900

gtcattgatc tgaggactat aataccttgg gatgtggaca caatttgtaa gtctgtgatc      960

aaaacagggc gactgctaat cagtcacgag gctcccttga caggcggctt tgcatcggaa     1020

atcagctcta cagttcagga ggaatgtttc ttgaacctag aggctcctat atcaagagta     1080

tgtggttatg acacaccatt tcctcacatt tttgaaccat tctacatccc agacaaatgg     1140

aagtgttatg atgcccttcg aaaaatgatc aactattga                            1179


<210>  1287
<211>  951
<212>  DNA
<213>  homo sapiens

<400>  1287
atggcggtgc aggtggtgca ggcggtgcag gcggttcatc tcgagtctga cgctttcctc       60

gtttgtctca accacgctct gagcacagag aaggaggaag taatggggct gtgcataggg      120

gagttgaacg atgatacaag gagtgactcc aaatttgcat atactggaac tgaaatgcgc      180

acagttgctg aaaaggttga tgccgtcaga attgttcaca ttcattctgt catcatctta      240

cgacgttctg ataagaggaa ggaccgagta gaaatttctc cagagcagct gtctgcagct      300

tcaacagagg cagagaggtt ggctgaactg acaggccgcc ccatgagagt tgtgggctgg      360

tatcattccc atcctcatat aactgtttgg ccttcacatg ttgatgttcg cacacaagcc      420

atgtaccaga tgatggatca aggctttgta ggacttattt tttcctgttt catagaagat      480

aagaacacaa agactggccg ggtactctac acttgcttcc aatccataca ggcccaaaag      540

agttcagagt cccttcatgg tccacgagac ttctggagct ccagccagca catctccatt      600

gagggccaga aggaagagga aaggtatgag agaatcgaaa tcccaatcca tattgtacct      660

catgtcacta tcgggaaagt gtgccttgaa tcagcagtag agctgcccaa gatcctgtgc      720

caggaggagc aggatgcgta taggaggatc cacagcctta cacatctgga ctcagtaacc      780

aagatccata atggctcagt gtttaccaag aatctgtgca gtcagatgtc ggcagtcagc      840

gggcctctcc tacagtggtt ggaggacaga ctggagcaaa accaacagca tttgcaggaa      900

ttacaacaag aaaaggaaga gcttatgcaa gaactttctt ctctagaata a               951


<210>  1288
<211>  1584
<212>  DNA
<213>  homo sapiens

<400>  1288
atggaatcag ctgctgccct gcacttctcc cggccagcct ccctcctcct cctcctcctc       60

agcctgtgtg cactggtctc agcccagttt attgtcgtgg ggcccactga tcccatcttg      120

gccacggttg gagaaaacac tacgttacgc tgccatctgt cacccgagaa aaatgctgag      180

gacatggagg tgcggtggtt ccggtctcag ttctcccccg cagtgtttgt gtataaaggt      240

ggcagagaga gaacagagga gcagatggag gagtaccgag gaagaaccac ctttgtgagc      300

aaagacatca gcaggggcag cgtggccctg gtcatacaca acatcacagc ccaggaaaac      360

ggcacctacc gctgttactt ccaagaaggc aggtcctacg atgaggccat cctgcacctc      420

gtagtggcag gactaggctc taagcccctc atttcaatga ggggccatga agacgggggc      480

atccggctgg agtgcatatc tagagggtgg tacccaaagc ccctcacagt gtggagggac      540

ccctacggtg gggttgcgcc tgccctgaaa gaggtctcca tgcctgatgc agacggcctc      600

ttcatggtca ccacggctgt gatcatcaga gacaagtctg tgaggaacat gtcctgctct      660

atcaacaaca ccctgctcgg ccagaagaaa gaaagtgtca tttttattcc agaatccttt      720

atgcccagtg tgtctccctg tgcagtggcc ctgcctatca ttgtggttat tctgatgata      780

cccattgccg tatgcatcta ttggatcaac aaactccaaa aggaaaaaaa gattctgtca      840

ggggaaaagg agtttgaacg ggaaacaaga gaaattgctc taaaggaact ggagaaagaa      900

cgtgtgcaaa aagaggaaga acttcaagta aaagagaaac ttcaagaaga attgcgatgg      960

agaagaacat tcttacatgc tgttgatgtg gtcctggatc cagacaccgc tcatcccgat     1020

ctcttcctgt cagaggaccg gagaagtgtg agaaggtgcc ccttcaggca cctaggggag     1080

agcgtgcctg acaacccaga gagattcgac agtcagcctt gtgtcctagg ccgggagagc     1140

ttcgcttcag ggaaacatta ctgggaggtg gaggtggaaa acgtgattga gtggactgtg     1200

ggggtctgta gagacagtgt tgagaggaaa ggggaggtcc tgctgattcc tcagaatggc     1260

ttctggacct tggagatgca taaagggcaa taccgggccg tgtcctcccc tgataggatt     1320

ctccctttga aggagtccct ttgccgggtg ggcgtcttcc tggactatga agctggagat     1380

gtctccttct acaacatgag ggacagatcg cacatctaca catgtccccg ttcagccttt     1440

tccgtgcctg tgaggccctt cttcaggttg gggtgtgagg acagccccat cttcatctgc     1500

cctgcactca caggagccaa tggggtcacg gtgcctgaag agggcctgac acttcacaga     1560

gtggggaccc accagagcct atag                                            1584


<210>  1289
<211>  1260
<212>  DNA
<213>  homo sapiens

<400>  1289
atgaataagc atcagaagcc agtgctaaca ggccagcggt tcaaaactcg gaaaagggat       60

gaaaaagaga aattcgaacc cacagtcttc agggatacac ttgtccaggg gcttaatgag      120

gctggtgatg accttgaagc tgtagccaaa tttctggact ctacaggctc aagattagat      180

tatcgtcgct atgcagacac actcttcgat atcctggtgg ctggcagtat gcttgcccct      240

ggaggaacgc gcatagatga tggtgacaag accaagatga ccaaccactg tgtgttttca      300

gcaaatgaag atcatgaaac catccgaaac tatgctcagg tcttcaataa actcatcagg      360

agatataagt atttggagaa ggcatttgaa gatgaaatga aaaagcttct cctcttcctt      420

aaagcctttt ccgaaacaga gcagacaaag ttggcgatgc tgtcggggat tctgctgggc      480

aatggcaccc tgcccgccac catcctcacc agtctcttca ccgacagctt agtcaaagaa      540

ggcattgcgg cctcatttgc tgtcaagctt ttcaaagcat ggatggcaga aaaagatgcc      600

aactctgtta cctcgtcttt gagaaaagcc aacttagaca agaggctgct tgaactcttt      660

ccagttaaca gacagagtgt ggatcatttt gctaaatact tcactgacgc aggtcttaag      720

gagctttccg acttcctccg agtccagcag tccctgggca ccaggaagga actgcagaag      780

gagctccagg agcgtctttc tcaggaatgc ccgatcaagg aggtggtgct ttatgtcaaa      840

gaagaaatga agaggaatga tcttccagaa acagcagtga ttggtcttct gtggacatgt      900

ataatgaacg ctgttgagtg gaacaagaag gaagaacttg ttgcagagca ggctctgaag      960

cacctgaagc aatatgctcc cctgctggcc gtgttcagct cccaaggcca gtcagagctg     1020

atcctcctcc agaaggttca ggaatactgc tacgacaaca tccatttcat gaaagccttt     1080

cagaagattg tggttctctt ttataaagct gatgttctga gcgaagaagc aatactgaaa     1140

tggtataagg aagcacatgt tgctaaaggc aaaagtgttt ttcttgacca gatgaagaaa     1200

tttgttgagt ggttacaaaa tgcagaagaa gaatccgaat cggaaggtga ggaaaattaa     1260


<210>  1290
<211>  423
<212>  DNA
<213>  homo sapiens

<400>  1290
atgagccgtt tcctgaatgt gttaagaagt tggctggtta tggtgtccat catagccatg       60

gggaacacgc tgcagagctt ccgagaccac acttttctct atgaaaagct ctacactggc      120

aagccaaacc ttgtgaatgg cctccaagct cggacctttg ggatctggac gctgctctca      180

tcagtgattc gctgcctctg tgccattgac attcacaaca agacgctcta tcacatcaca      240

ctctggacct tcctccttgc cctggggcat ttcctctctg agttgtttgt ctatggaact      300

gcagctccca cgattggcgt cctggcaccc ctgatggtgg caagtttctc catcctgggt      360

atgctggtcg ggctccggta tctagaagta gaaccagtat ccagacagaa gaagagaaac      420

tga                                                                    423


<210>  1291
<211>  663
<212>  DNA
<213>  homo sapiens

<400>  1291
atgctcaggc tgctcttggc tctcaactta ttcccttcaa ttcaagtaac aggaaacaag       60

attttggtga agcagtcgcc catgcttgta gcgtacgaca atgcggtcaa ccttagctgc      120

aagtattcct acaatctctt ctcaagggag ttccgggcat cccttcacaa aggactggat      180

agtgctgtgg aagtctgtgt tgtatatggg aattactccc agcagcttca ggtttactca      240

aaaacggggt tcaactgtga tgggaaattg ggcaatgaat cagtgacatt ctacctccag      300

aatttgtatg ttaaccaaac agatatttac ttctgcaaaa ttgaagttat gtatcctcct      360

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      420

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      480

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg      540

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg      600

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc      660

tga                                                                    663


<210>  1292
<211>  786
<212>  DNA
<213>  homo sapiens

<400>  1292
atgatcgaaa catacaacca aacttctccc cgatctgcgg ccactggact gcccatcagc       60

atgaaaattt ttatgtattt acttactgtt tttcttatca cccagatgat tgggtcagca      120

ctttttgctg tgtatcttca tagaaggttg gacaagatag aagatgaaag gaatcttcat      180

gaagattttg tattcatgaa aacgatacag agatgcaaca caggagaaag atccttatcc      240

ttactgaact gtgaggagat taaaagccag tttgaaggct ttgtgaagga tataatgtta      300

aacaaagagg agacgaagaa agaaaacagc tttgaaatgc aaaaaggtga tcagaatcct      360

caaattgcgg cacatgtcat aagtgaggcc agcagtaaaa caacatctgt gttacagtgg      420

gctgaaaaag gatactacac catgagcaac aacttggtaa ccctggaaaa tgggaaacag      480

ctgaccgtta aaagacaagg actctattat atctatgccc aagtcacctt ctgttccaat      540

cgggaagctt cgagtcaagc tccatttata gccagcctct gcctaaagtc ccccggtaga      600

ttcgagagaa tcttactcag agctgcaaat acccacagtt ccgccaaacc ttgcgggcaa      660

caatccattc acttgggagg agtatttgaa ttgcaaccag gtgcttcggt gtttgtcaat      720

gtgactgatc caagccaagt gagccatggc actggcttca cgtcctttgg cttactcaaa      780

ctctga                                                                 786


<210>  1293
<211>  987
<212>  DNA
<213>  homo sapiens

<400>  1293
atggctcagc accacctatg gatcttgctc ctttgcctgc aaacctggcc ggaagcagct       60

ggaaaagact cagaaatctt cacagtgaat gggattctgg gagagtcagt cactttccct      120

gtaaatatcc aagaaccacg gcaagttaaa atcattgctt ggacttctaa aacatctgtt      180

gcttatgtaa caccaggaga ctcagaaaca gcacccgtag ttactgtgac ccacagaaat      240

tattatgaac ggatacatgc cttaggtccg aactacaatc tggtcattag cgatctgagg      300

atggaagacg caggagacta caaagcagac ataaatacac aggctgatcc ctacaccacc      360

accaagcgct acaacctgca aatctatcgt cggcttggga aaccaaaaat tacacagagt      420

ttaatggcat ctgtgaacag cacctgtaat gtcacactga catgctctgt agagaaagaa      480

gaaaagaatg tgacatacaa ttggagtccc ctgggagaag agggtaatgt ccttcaaatc      540

ttccagactc ctgaggacca agagctgact tacacgtgta cagcccagaa ccctgtcagc      600

aacaattctg actccatctc tgcccggcag ctctgtgcag acatcgcaat gggcttccgt      660

actcaccaca ccgggttgct gagcgtgctg gctatgttct ttctgcttgt tctcattctg      720

tcttcagtgt ttttgttccg tttgttcaag agaagacaag atgctgcctc aaagaaaacc      780

atatacacat atatcatggc ttcaaggaac acccagccag cagagtccag aatctatgat      840

gaaatcctgc agtccaaggt gcttccctcc aaggaagagc cagtgaacac agtttattcc      900

gaagtgcagt ttgctgataa gatggggaaa gccagcacac aggacagtaa acctcctggg      960

acttcaagct atgaaattgt gatctag                                          987


<210>  1294
<211>  441
<212>  DNA
<213>  homo sapiens

<400>  1294
atggcccaga agcgtcctgc ctgcaccctg aagcctgagt gtgtccagca gctgctggtt       60

tgctcccagg aggccaagaa gtcagcctac tgcccctaca gtcactttcc tgtgggggct      120

gccctgctca cccaggaggg gagaatcttc aaagggtgca acatagaaaa tgcctgctac      180

ccgctgggca tctgtgctga acggaccgct atccagaagg ccgtctcaga agggtacaag      240

gatttcaggg caattgctat cgccagtgac atgcaagatg attttatctc tccatgtggg      300

gcctgcaggc aagtcatgag agagtttggc accaactggc ccgtgtacat gaccaagccg      360

gatggtacgt atattgtcat gacggtccag gagctgctgc cctcctcctt tgggcctgag      420

gacctgcaga agacccagtg a                                                441


<210>  1295
<211>  981
<212>  DNA
<213>  homo sapiens

<400>  1295
atggagaagg acggcctgtg ccgcgctgac cagcagtacg aatgcgtggc ggagatcggg       60

gagggcgcct atgggaaggt gttcaaggcc cgcgacttga agaacggagg ccgtttcgtg      120

gcgttgaagc gcgtgcgggt gcagaccggc gaggagggca tgccgctctc caccatccgc      180

gaggtggcgg tgctgaggca cctggagacc ttcgagcacc ccaacgtggt caggttgttt      240

gatgtgtgca cagtgtcacg aacagacaga gaaaccaaac taactttagt gtttgaacat      300

gtcgatcaag acttgaccac ttacttggat aaagttccag agcctggagt gcccactgaa      360

accataaagg atatgatgtt tcagcttctc cgaggtctgg actttcttca ttcacaccga      420

gtagtgcatc gcgatctaaa accacagaac attctggtga ccagcagcgg acaaataaaa      480

ctcgctgact tcggccttgc ccgcatctat agtttccaga tggctctaac ctcagtggtc      540

gtcacgctgt ggtacagagc acccgaagtc ttgctccagt ccagctacgc cacccccgtg      600

gatctctgga gtgttggctg catatttgca gaaatgtttc gtagaaagcc tctttttcgt      660

ggaagttcag atgttgatca actaggaaaa atcttggacg tgattggact cccaggagaa      720

gaagactggc ctagagatgt tgcccttccc aggcaggctt ttcattcaaa atctgcccaa      780

ccaattgaga agtttgtaac agatatcgat gaactaggca aagacctact tctgaagtgt      840

ttgacattta acccagccaa aagaatatct gcctacagtg ccctgtctca cccatacttc      900

caggacctgg aaaggtgcaa agaaaacctg gattcccacc tgccgcccag ccagaacacc      960

tcggagctga atacagcctg a                                                981


<210>  1296
<211>  597
<212>  DNA
<213>  homo sapiens

<400>  1296
atgtcaaacg tgcgagtgtc taacgggagc cctagcctgg agcggatgga cgccaggcag       60

gcggagcacc ccaagccctc ggcctgcagg aacctcttcg gcccggtgga ccacgaagag      120

ttaacccggg acttggagaa gcactgcaga gacatggaag aggcgagcca gcgcaagtgg      180

aatttcgatt ttcagaatca caaaccccta gagggcaagt acgagtggca agaggtggag      240

aagggcagct tgcccgagtt ctactacaga cccccgcggc cccccaaagg tgcctgcaag      300

gtgccggcgc aggagagcca ggatgtcagc gggagccgcc cggcggcgcc tttaattggg      360

gctccggcta actctgagga cacgcatttg gtggacccaa agactgatcc gtcggacagc      420

cagacggggt tagcggagca atgcgcagga ataaggaagc gacctgcaac cgacgattct      480

tctactcaaa acaaaagagc caacagaaca gaagaaaatg tttcagacgg ttccccaaat      540

gccggttctg tggagcagac gcccaagaag cctggcctca gaagacgtca aacgtaa         597


<210>  1297
<211>  2049
<212>  DNA
<213>  homo sapiens

<400>  1297
atgagcacac cggccgtgcc ccaggacctg cagctgcccc cgagtcagag ggcgcagtcc       60

gcattcaaag agcaaagaag acaaaaactc aaggaacatc tgttgagaag aaaaacgctt      120

tttgcataca agcaggaaaa tgagatgtta tccagtagag atcagagagt tgtgacatct      180

gaggaccaag ttcaagaagg gactaaagtg ctgaaactta aaacaaaaat ggctgataaa      240

gaaaacatga agagacctgc agagagcaaa aataatacag tggtggggaa acattgtatt      300

cctttaaaac cttcaaatga actaaccaat tcaactgtag taattgacac acataaacct      360

aaggatagta atcaaactcc gcatttgtta ctaactgaag atgatcccca aagtcaacat      420

atgacattaa gccaggcatt tcaccttaaa aacaatagta aaaagaaaca aatgactaca      480

gaaaaacaaa agcaagatgc taacatgccc aagaaacctg tgcttggatc ttatcgtggc      540

cagattgttc agtctaagat taattcattt agaaaacctc tacaagtcaa agatgagagt      600

tctgcagcaa caaagaaact ttcagccact atacctaaag ccacaaaacc tcagcctgta      660

aacaccagca gtgtaacagt gaaaagtaat agatcctcca atatgactgc cactactaaa      720

tttgtgagca ctacatctca gaacacacaa cttgtgcgac ctcctattag aagtcatcac      780

agtaataccc gggacactgt gaaacaaggc atcagtagaa cttctgccaa tgttacaatc      840

cggaaagggc ctcatgaaaa agaactatta caatcaaaaa cagctttatc tagtgtcaaa      900

accagttctt ctcaaggtat aataagaaat aagactctat caagatccat agcatctgaa      960

gttatagcca ggcctgcttc attgtctaat gataaactga tggaaaagtc agagcccgtt     1020

gaccagcgaa gacatactgc aggaaaagca attgttgata gtagatcagc tcagcccaaa     1080

gaaacctcgg aagagagaaa agctcgtctg agtgagtgga aagctggcaa aggaagagtg     1140

ctaaaaaggc cccctaattc agtagttact cagcatgagc ctgcaggaca aaatgaaaaa     1200

ccagttgggt ctttttggac taccatggca gaagaagatg aacaaagatt atttactgaa     1260

aaagtaaaca acacattttc tgaatgcctg aacttgatta atgagggatg tccaaaagaa     1320

gatatactgg tcacactgaa tgacctgatt aaaaatattc cagatgccaa aaagcttgtt     1380

aagtattgga tatgtcttgc acttattgaa ccaatcacaa gtcctattga aaatattatt     1440

gcaatctatg agaaagccat tctggcaggg gctcagccta ttgaagagat gcgacacacg     1500

attgtagata ttctaacaat gaagagtcaa gaaaaagcta atttaggaga aaatatggag     1560

aagtcttgtg caagcaagga agaagtcaaa gaagtcagta ttgaagatac aggtgttgat     1620

gtagatccag aaaaactgga aatggagagt aaacttcata gaaatttgct atttcaagat     1680

tgtgaaaaag agcaagacaa caaaacaaaa gatccaaccc atgatgttaa aacccccaat     1740

acagaaacga ggacaagttg cttaattaaa tataatgtgt ctactacgcc atacttgcaa     1800

agtgtgaaaa aaaaggtgca gtttgatgga acaaattccg catttaaaga gctgaagttt     1860

ttaacaccag tgagacgttc tcgacgtctt caagagaaaa cttctaaatt gccagatatg     1920

ttaaaagatc attatccttg tgtgtcttca ttggaacagc taacggagtt gggaagagaa     1980

actgatgctt ttgtatgccg ccctaatgca gcactgtgcc gggtgtacta tgaggctgat     2040

acaacataa                                                             2049


<210>  1298
<211>  660
<212>  DNA
<213>  homo sapiens

<400>  1298
atgaattcat ctaaatcatc tgaaacacaa tgcacagaga gaggatgctt ctcttcccaa       60

atgttcttat ggactgttgc tgggatcccc atcctatttc tcagtgcctg tttcatcacc      120

agatgtgttg tgacatttcg catctttcaa acctgtgatg agaaaaagtt tcagctacct      180

gagaatttca cagagctctc ctgctacaat tatggatcag gttcagtcaa gaattgttgt      240

ccattgaact gggaatattt tcaatccagc tgctacttct tttctactga caccatttcc      300

tgggcgttaa gtttaaagaa ctgctcagcc atgggggctc acctggtggt tatcaactca      360

caggaggagc aggaattcct ttcctacaag aaacctaaaa tgagagagtt ttttattgga      420

ctgtcagacc aggttgtcga gggtcagtgg caatgggtgg acggcacacc tttgacaaag      480

tctctgagct tctgggatgt aggggagccc aacaacatag ctaccctgga ggactgtgcc      540

accatgagag actcttcaaa cccaaggcaa aattggaatg atgtaacctg tttcctcaat      600

tattttcgga tttgtgaaat ggtaggaata aatcctttga acaaaggaaa atctctttaa      660


<210>  1299
<211>  2541
<212>  DNA
<213>  homo sapiens

<400>  1299
atgttgttta ccgtaagctg tagtaaaatg agctcgattg ttgacagaga tgacagtagt       60

atttttgatg ggttggtgga agaagatgac aaggacaaag cgaaaagagt atctagaaac      120

aaatctgaaa agaaacgtag agatcaattt aatgttctca ttaaagaact gggatccatg      180

cttcctggta atgctagaaa gatggacaaa tctactgttc tgcagaaaag cattgatttt      240

ttacgaaaac ataaagaaat cactgcacag tcagatgcta gtgaaattcg acaggactgg      300

aaacctacat tccttagtaa tgaagagttt acacaattaa tgttagaggc tcttgatggt      360

ttttttttag caatcatgac agatggaagc ataatatatg tgtctgagag tgtaacttca      420

ttacttgaac atttaccatc tgatcttgtg gatcaaagta tatttaattt tatcccagaa      480

ggggaacatt cagaggttta taaaatactc tctactcatc tgctggaaag tgattcatta      540

accccagaat atttaaaatc aaaaaatcag ttagaattct gttgtcacat gctgcgagga      600

acaatagacc caaaggagcc atctacctat gaatatgtaa aatttatagg aaatttcaaa      660

tctttaaaca gtgtatcctc ttcagcacac aatggttttg aaggaactat acaacgcaca      720

cataggccat cttatgaaga tagagtttgt tttgtagcta ctgtcaggtt agctacacct      780

cagttcatca aggaaatgtg cactgttgaa gaacccaatg aagagtttac atctagacat      840

agtttagaat ggaagtttct gtttctagat cacagggcac cacccataat agggtatttg      900

ccatttgaag ttctgggaac atcaggctat gattactatc atgtggatga cctagaaaat      960

ttggcaaaat gtcatgagca cttaatgcaa tatgggaaag gcaaatcatg ttattatagg     1020

ttcctgacta aggggcaaca gtggatttgg cttcagactc attattatat cacttaccat     1080

cagtggaatt caaggccaga gtttattgtt tgtactcaca ctgtagtaag ttatgcagaa     1140

gttagggctg aaagacgacg agaacttggc attgaagagt ctcttcctga gacagctgct     1200

gacaaaagcc aagattctgg gtcagataat cgtataaaca cagtcagtct caaggaagca     1260

ttggaaaggt ttgatcacag cccaacccct tctgcctctt ctcggagttc aagaaaatca     1320

tctcacacgg ccgtctcaga cccttcctca acaccaacca agatcccgac ggatacgagc     1380

actccaccca ggcagcattt accagctcat gagaagatgg tgcaaagaag gtcatcattt     1440

agtagtcagt ccataaattc ccagtctgtt ggttcatcat taacacagcc agtgatgtct     1500

caagctacaa atttaccaat tccacaaggc atgtcccagt ttcagttttc agctcaatta     1560

ggagccatgc aacatctgaa agaccaattg gaacaacgga cacgcatgat agaagcaaat     1620

attcatcggc aacaagaaga actaagaaaa attcaagaac aacttcagat ggtccatggt     1680

caggggctgc agatgttttt gcaacaatca aatcctgggt tgaattttgg ttccgttcaa     1740

ctttcttctg gaaattcatc taatatccag caacttgcac ctataaatat gcaaggccaa     1800

gttgttccta ctaaccagat tcaaagtgga atgaatactg gacacattgg cacaactcag     1860

cacatgatac aacaacagac tttacagagt acatcaactc agagtcaaca aaatgtactg     1920

agtgggcaca gtcagcaaac atctctaccc agtcagacac agagcactct tacagcccca     1980

ctgtataaca ctatggtgat ttctcagcct gcagccggaa gcatggtcca gattccatct     2040

agtatgccac aaaacagcac ccagagtgct gcagtaacta cattcactca ggacaggcag     2100

ataagatttt ctcaaggtca acaacttgtg accaaattag tgactgctcc tgtagcttgt     2160

ggggcagtca tggtacctag tactatgctt atgggccagg tggtgactgc atatcctact     2220

tttgctacac aacagcaaca gtcacagaca ttgtcagtaa cgcagcagca gcagcagcag     2280

agctcccagg agcagcagct cacttcagtt cagcaaccat ctcaggctca gctgacccag     2340

ccaccgcaac aatttttaca gacttctagg ttgctccatg ggaatccctc aactcaactc     2400

attctctctg ctgcatttcc tctacaacag agcaccttcc ctcagtcaca tcaccagcaa     2460

catcagtctc agcaacagca gcaactcagc cggcacagga ctgacagctt gcccgaccct     2520

tccaaggttc aaccacagta g                                               2541


<210>  1300
<211>  1242
<212>  DNA
<213>  homo sapiens

<400>  1300
atgtctttcc gcgacctccg caatttcaca gagatgatga gagccctggg ataccctcga       60

catatttcta tggaaaattt ccgtacaccc aattttggac ttgtatctga agtgcttctc      120

tggcttgtga aaagatatga gccccagact gacatcccgc ctgacgtgga tactgaacag      180

gaccgagttt tcttcattaa ggcaattgcc cagttcatgg ccaccaaggc acatataaaa      240

ctcaacacta agaagcttta tcaagcagat gggtatgcgg taaaagagct gctgaagatc      300

acatctgtcc tttataatgc tatgaagacc aaggggatgg agggctctga aatagtagag      360

gaagatgtca acaagttcaa gtttgatctt ggctcaaaga ttgcagattt gaaggcagcc      420

aggcagcttg cgtctgaaat cacctccaaa ggagcatctc tgtatgactt gctcggcatg      480

gaagtagagt tgagggaaat gagaacagaa gccattgcca gacctctgga aataaacgag      540

actgaaaaag tgatgagaat tgcaataaaa gagattttga cacaggttca gaagactaaa      600

gacctgctca ataatgtggc ctctgatgaa gctaatttag aagccaaaat cgaaaagaga      660

aaattagaac tggaaagaaa tcggaagcga ctagagactc tgcagagtgt caggccatgt      720

tttatggatg agtatgagaa gactgaggaa gaattacaaa agcagtatga cacttatctg      780

gagaaatttc aaaatctgac ttatctggaa caacagcttg aagaccatca taggatggag      840

caagaaaggt ttgaggaagc taaaaacact ctctgcctga tacagaacaa gctcaaggag      900

gaagagaagc gcctgctcaa gagtggaagt aacgatgact cggacataga catccaggag      960

gacgatgaat ccgacagtga gttggaagaa aggcggctgc ccaagccaca gacagccatg     1020

gagatgctca tgcaaggaag acctggcaaa cgcattgtgg gcacgatgca aggtggagac     1080

tccgatgaca atgaggactc ggaggagagt gaaattgaca tggaagatga tgatgacgag     1140

gatgacgatt tggaagacga gagcatttct ctctcaccaa ccaagcccaa tcgaagggtc     1200

cggaaatctg aacccctgga tgagagtgac aatgacttct ga                        1242


<210>  1301
<211>  1254
<212>  DNA
<213>  homo sapiens

<400>  1301
atgaggctca tcctgcctgt gggtttgatt gctaccactc ttgcaattgc tcctgtccgc       60

tttgacaggg agaaggtgtt ccgcgtgaag ccccaggatg aaaaacaagc agacatcata      120

aaggacttgg ccaaaaccaa tgagcttgac ttctggtatc caggtgccac ccaccacgta      180

gctgctaata tgatggtgga tttccgagtt agtgagaagg aatcccaagc catccagtct      240

gccttggatc aaaataaaat gcactatgaa atcttgattc atgatctaca agaagagatt      300

gagaaacagt ttgatgttaa agaagatatc ccaggcaggc acagctacgc aaaatacaat      360

aattgggaaa agattgtggc ttggactgaa aagatgatgg ataagtatcc tgaaatggtc      420

tctcgtatta aaattggatc tactgttgaa gataatccac tatatgttct gaagattggg      480

gaaaagaatg aaagaagaaa ggctattttt acggattgtg gcattcacgc acgagaatgg      540

gtctccccag cattctgcca gtggtttgtc tatcaggcaa ccaaaactta tgggagaaac      600

aaaattatga ccaaactctt ggaccgaatg aatttttaca ttcttcctgt gttcaatgtt      660

gatggatata tttggtcatg gacaaagaac cgcatgtgga gaaaaaatcg ttccaagaac      720

caaaactcca aatgcatcgg cactgacctc aacaggaatt ttaatgcttc atggaactcc      780

attcctaaca ccaatgaccc atgtgcagat aactatcggg gctctgcacc agagtccgag      840

aaagagacga aagctgtcac taatttcatt agaagccacc tgaatgaaat caaggtttac      900

atcaccttcc attcctactc ccagatgcta ttgtttccct atggatatac atcaaaactg      960

ccacctaacc atgaggactt ggccaaagtt gcaaagattg gcactgatgt tctatcaact     1020

cgatatgaaa cccgctacat ctatggccca atagaatcaa caatttaccc gatatcaggt     1080

tcttctttag actgggctta tgacctgggc atcaaacaca catttgcctt tgagctccga     1140

gataaaggca aatttggttt tctccttcca gaatcccgga taaagccaac gtgcagagag     1200

accatgctag ctgtcaaatt tattgccaag tatatcctca agcatacttc ctaa           1254


<210>  1302
<211>  984
<212>  DNA
<213>  homo sapiens

<400>  1302
atgaccatgg aatctggagc cgagaaccag cagagtggag atgcagctgt aacagaagct       60

gaaaaccaac aaatgacagt tcaagcccag ccacagattg ccacattagc ccaggtatct      120

atgccagcag ctcatgcaac atcatctgct cccaccgtaa ctctagtaca gctgcccaat      180

gggcagacag ttcaagtcca tggagtcatt caggcggccc agccatcagt tattcagtct      240

ccacaagtcc aaacagttca gatttcaact attgcagaaa gtgaagattc acaggagtca      300

gtggatagtg taactgattc ccaaaagcga agggaaattc tttcaaggag gccttcctac      360

aggaaaattt tgaatgactt atcttctgat gcaccaggag tgccaaggat tgaagaagag      420

aagtctgaag aggagacttc agcacctgcc atcaccactg taacggtgcc aactccaatt      480

taccaaacta gcagtggaca gtatattgcc attacccagg gaggagcaat acagctggct      540

aacaatggta ccgatggggt acagggcctg caaacattaa ccatgaccaa tgcagcagcc      600

actcagccgg gtactaccat tctacagtat gcacagacca ctgatggaca gcagatctta      660

gtgcccagca accaagttgt tgttcaagct gcctctggag acgtacaaac ataccagatt      720

cgcacagcac ccactagcac tattgcccct ggagttgtta tggcatcctc cccagcactt      780

cctacacagc ctgctgaaga agcagcacga aagagagagg tccgtctaat gaagaacagg      840

gaagcagctc gagagtgtcg tagaaagaag aaagaatatg tgaaatgttt agaaaacaga      900

gtggcagtgc ttgaaaatca aaacaagaca ttgattgagg agctaaaagc acttaaggac      960

ctttactgcc acaaatcaga ttaa                                             984


<210>  1303
<211>  1563
<212>  DNA
<213>  homo sapiens

<400>  1303
atgccacagc tgagcctgtc ctcgctgggc ctttggccaa tggcagcatc cccgtggctg       60

ctcctgctgc tggttggggc ctcctggctc ctggcccgca tcctggcctg gacctatacc      120

ttctatgaca actgctgccg cctccggtgt ttcccgcaac ccccgaaacg gaattggttc      180

ttgggtcacc tgggcctgat tcacagctcg gaggaaggtc tcctatacac acaaagcctg      240

gcatgcacct tcggtgatat gtgctgctgg tgggtggggc cctggcacgc aatcgtccgc      300

atcttccacc ccacctacat caagcctgtg ctctttgctc cagctgccat tgtaccaaag      360

gacaaggtct tctacagctt cctgaagccc tggctggggg atgggctcct gctgagtgct      420

ggtgaaaagt ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg      480

aagccctata tgaagatttt caatgagagt gtgaacatca tgcatgccaa gtggcagctc      540

ctggcctcag agggtagtgc ccgtctggac atgtttgagc acatcagcct catgaccttg      600

gacagtctgc agaaatgtgt cttcagcttt gacagccatt gccaggagaa gcccagtgaa      660

tatattgccg ccatcttgga gctcagtgcc cttgtgacaa aaagacacca gcagatcctc      720

ctgtacatag acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc      780

cgcctggtgc acgacttcac agatgccgtc atccaggagc ggcgccgcac cctccctagc      840

cagggtgttg atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat      900

gtactcctgc tgagcaagga tgaagatggg aagaagttgt ccgatgagga cataagagca      960

gaagctgaca cctttatgtt tgagggccat gacaccacag ccagtggtct ctcctgggtc     1020

ctgtaccacc ttgcaaagca cccggaatac caggagcgct gtcggcagga ggtgcaagag     1080

cttctgaagg accgtgagcc taaagagatt gaatgggacg acctggccca gctgcccttc     1140

ctgaccatgt gcattaagga gagcctgagg ctgcatcccc cagtccctgc cgtctctcgc     1200

tgctgcaccc aagacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc     1260

ctcatcagtg tttttggaac ccatcacaac ccagccgtgt ggccggaccc tgaggtctat     1320

gacccctttc gctttgaccc aaagaacatc aaggagaggt cacctctggc ttttattccc     1380

ttctcagcag ggcccaggaa ctgcatcggg caggcgttcg cgatggcgga gatgaaggtg     1440

gtcctggggc tcacgctgct gcgcttccgc gtcctgcctg accacaccga gccccgcagg     1500

aagccggagc tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc     1560

tga                                                                   1563


<210>  1304
<211>  1014
<212>  DNA
<213>  homo sapiens

<400>  1304
atggatgaaa caggaaatct gacagtatct tctgccacat gccatgacac tattgatgac       60

ttccgcaatc aagtgtattc caccttgtac tctatgatct ctgttgtagg cttctttggc      120

aatggctttg tgctctatgt cctcataaaa acctatcaca agaagtcagc cttccaagta      180

tacatgatta atttagcagt agcagatcta ctttgtgtgt gcacactgcc tctccgtgtg      240

gtctattatg ttcacaaagg catttggctc tttggtgact tcttgtgccg cctcagcacc      300

tatgctttgt atgtcaacct ctattgtagc atcttcttta tgacagccat gagctttttc      360

cggtgcattg caattgtttt tccagtccag aacattaatt tggttacaca gaaaaaagcc      420

aggtttgtgt gtgtaggtat ttggattttt gtgattttga ccagttctcc atttctaatg      480

gccaaaccac aaaaagatga gaaaaataat accaagtgct ttgagccccc acaagacaat      540

caaactaaaa atcatgtttt ggtcttgcat tatgtgtcat tgtttgttgg ctttatcatc      600

ccttttgtta ttataattgt ctgttacaca atgatcattt tgaccttact aaaaaaatca      660

atgaaaaaaa atctgtcaag tcataaaaag gctataggaa tgatcatggt cgtgaccgct      720

gcctttttag tcagtttcat gccatatcat attcaacgta ccattcacct tcatttttta      780

cacaatgaaa ctaaaccctg tgattctgtc cttagaatgc agaagtccgt ggtcataacc      840

ttgtctctgg ctgcatccaa ttgttgcttt gaccctctcc tatatttctt ttctgggggt      900

aactttagga aaaggctgtc tacattcaga aagcattctt tgtccagcgt gacttatgta      960

cccagaaaga aggcctcttt gccagaaaaa ggagaagaaa tatgtaaagt atag           1014


<210>  1305
<211>  3306
<212>  DNA
<213>  homo sapiens

<400>  1305
atggagcagc ccggggcggc ggcgtcggga gcgggaggcg gcagcgagga acccggtggg       60

ggccggagca acaagcggag cgcggggaac cgggccgcca atgaagagga aacgaaaaac      120

aaacccaaat tgaacattca aataaaaact ttggcagatg atgtgcgtga ccgaattaca      180

agttttagaa aatctactgt caaaaaagaa aaacctctta ttcaacatcc tattgattct      240

caagtcgcga tgagtgagtt tcctgcagct cagccattat atgatgaacg atctttgaat      300

ttgtcagaaa aggaagtatt ggatctcttt gaaaaaatga tggaggacat gaaccttaac      360

gaagagaaaa aagctccttt acgaaacaaa gactttacca ccaaacgtga gatggttgtc      420

cagtatattt ctgccactgc caaatctggt gggctgaaaa acagcaaaca tgaatgcacc      480

ctgtcttcac aagaatatgt tcatgaatta cgatcgggta tatcagatga gaaacttctt      540

aattgcctag aatccctcag ggtttcttta accagcaatc cggtcagctg ggttaacaac      600

tttggccatg aaggtcttgg actcttattg gatgagctgg aaaagcttct ggacaaaaaa      660

cagcaagaaa atattgacaa gaagaatcag tataaactta ttcaatgcct caaagcattt      720

atgaataata agtttggatt acaaaggatt ctaggagatg aaagaagtct tttactattg      780

gcaagagcaa ttgaccccaa acaacccaac atgatgactg aaatagtaaa aatactttct      840

gctatttgca ttgttggaga agagaacatt ctagataaac ttttaggggc tataacaaca      900

gcagcagaaa gaaataacag ggaacgattt tcaccaattg tggaaggttt agaaaatcag      960

gaagccttgc aattacaggt ggcctgcatg cagtttataa atgcccttgt cacttctcct     1020

tatgagcttg attttcgaat acatttaagg aatgaattcc tccgttcagg actaaaaaca     1080

atgttaccag atctaaaaga aaaagagaat gatgagcttg atattcagtt gaaagtattt     1140

gatgaaaaca aagaagatga cctaactgaa ttatcacacc gtctcaatga cattcgagca     1200

gaaatggatg atatgaatga agtctaccat cttctatata atatgctgaa ggacactgct     1260

gctgaaaatt acttcttatc tattctacaa cattttttgc ttatcagaaa tgattattat     1320

atcaggccac aatattataa aataattgag gaatgtgttt cacagatagt gctacactgc     1380

agtggtatgg atccagactt caaatacagg caaagattag acatcgattt aactcatctg     1440

atagattctt gtgtgaacaa ggcgaaagtt gaagaaagtg aacaaaaagc tgcagagttt     1500

tcaaagaagt tcgatgaaga attcacagct cgacaggaag ctcaagcaga gcttcaaaaa     1560

agagatgaga aaatcaaaga acttgaagca gaaatccagc aacttcgaac ccaggcacaa     1620

gtactctcaa gttcatcagg aattccaggt cctcctgcag cacctccatt gccaggtgta     1680

gggccgcctc caccaccacc cgcgccacct ctacccggag gagctcctct tcctcctcca     1740

ccacctcctt tacctggaat gatggggata ccaccaccac ccccaccacc acttttattt     1800

gggggacctc ctccaccacc accccttgga ggagttcctc ctcccccagg aatatcactt     1860

aatctacctt atggaatgaa gcagaaaaaa atgtataaac ctgaagtgtc catgaagaga     1920

atcaattggt caaagattga acccacagaa ttatctgaga actgtttctg gttaagagtc     1980

aaagaagaca agtttgagaa tccagatctc tttgccaaat tggcattgaa ttttgctact     2040

cagataaaag ttcaaaagaa cgcagaagca ttagaagaaa agaagactgg gcctacaaag     2100

aagaaagtga aagaactgag aattttggat cccaaaacag ctcagaatct gtccatcttt     2160

ctgggatcat atcgcatgcc atatgaagac ataagaaacg ttattctgga ggttaatgaa     2220

gacatgctga gtgaggcttt aattcagaac cttgtgaaac atcttcctga gcagaagata     2280

ctcaacgaat tagcagagct taagaatgaa tatgatgacc tctgtgagcc tgaacaattt     2340

ggagttgtga tgagctctgt gaaaatgtta cagcctcgtc tcagtagtat cctgttcaag     2400

ctcacatttg aagaacacat aaacaacatc aaaccaagca tcatagcagt aactcttgcc     2460

tgtgaagaac tgaagaaaag tgaaagcttt aacagacttt tagagttagt tcttcttgtt     2520

ggaaactaca tgaactcagg ctcaagaaat gcccagtctt tgggatttaa gatcaacttc     2580

ctttgtaaga tcagagatac taaatcagcg gatcaaaaaa caaccctttt gcattttatt     2640

gccgacattt gtgaggaaaa atatcgagat atcctaaaat ttcctgaaga actggaacac     2700

gtagaaagtg caagcaaagt ttcagctcaa attctcaaga gcaaccttgc atcaatggaa     2760

caacaaattg ttcatctgga acgtgacatc aagaaattcc cccaagcaga aaatcaacac     2820

gataagtttg tggaaaagat gaccagcttt acaaagactg cccgagaaca gtatgaaaaa     2880

ctctccacca tgcacaacaa catgatgaag ctctatgaga atcttggaga atacttcatt     2940

tttgactcaa agacagtgag catagaagag ttctttggtg atctcaacaa cttccgaact     3000

ttgtttttgg aagcagtgag agaaaacaat aagagaagag aaatggaaga gaagaccagg     3060

agggcaaaac ttgcaaaaga gaaagctgaa caagaaaagt tagaacgcca gaagaaaaag     3120

aaacaactca ttgatataaa caaagagggt gatgagactg gtgtgatgga taatcttcta     3180

gaagccctac aatcaggtgc agcattcaga gaccgtcgaa agcggattcc aaggaatcca     3240

gataacagac gagtaccttt ggaaaggtca cgctctcgcc acaatggagc tatctcatct     3300

aagtga                                                                3306


<210>  1306
<211>  723
<212>  DNA
<213>  homo sapiens

<400>  1306
atggccacgg acgagctggc caccaagctg agccggcggc tgcagatgga gggcgagggc       60

ggcggcgaga ccccggagca gcccgggctg aacggggcag cggcggcggc ggcgggggca      120

cccgacgagg cggccgaggc gctgggcagc gcggactgcg agctgagcgc caagctgctg      180

cggcgcgcag acctcaacca gggcatcggc gagccccagt cgcccagccg ccgcgtcttc      240

aacccctaca ccgagttcaa ggagttctcc aggaagcaga tcaaggacat ggagaagatg      300

ttcaagcagt atgatgccgg gcgggacggc ttcatcgacc tgatggagct aaaactcatg      360

atggagaaac ttggggcccc tcagacccac ctgggcctga aaaacatgat caaggaggtg      420

gatgaggact ttgacagcaa gctgagcttc cgggagttcc tcctgatctt ccgcaaggcg      480

gcggccgggg agcttcagga ggacagcggg ctgtgcgtgc tggcccgcct ctctgagatc      540

gacgtctcca gtgagggtgt caagggggcc aagagcttct ttgaggccaa ggtccaggcc      600

atcaacgtgt ccagccgctt cgaggaggag atcaaggcag agcaggagga aaggaagaag      660

caggcggagg agatgaagca gcggaaagcg gccttcaagg agctgcagtc cacctttaag      720

tag                                                                    723


<210>  1307
<211>  3363
<212>  DNA
<213>  homo sapiens

<400>  1307
atggtgctca acagtttgga taagatgatt caactccaga aaaacactgc caacatcagg       60

aatatttgtg ttttggctca tgttgaccat ggaaaaacta ctctggctga ctgtcttata      120

tctagcaatg gaatcatctc cagccgccta gcaggcaagt taaggtacat ggacagcaga      180

gaagatgaac agatccgagg gatcactatg aaatccagtg ccatttccct acattatgca      240

acaggtaatg aggagtacct gatcaatctg atagactctc caggacacgt ggacttttcc      300

tcagaagtat caaccgctgt tcgcatttgt gatggatgca tcattgtggt agatgctgtg      360

gaaggagtct gtccacagac acaggcagtt ctgcgacaag cttggcttga aaacatccgt      420

ccggttttag tgattaataa gattgatcgc ttgatagtgg aactgaaatt caccccacaa      480

gaggcctatt ctcacctcaa gaatatttta gaacagatta atgcgctcac agggactctt      540

tttacttcta aagtcctaga agaaagagca gagagggaga ctgaatccca agtgaatcca      600

aattctgaac aaggagagca agtatatgac tggagcactg gcttggagga cacagatgat      660

tctcaccttt acttctctcc agaacaggga aatgtggtgt ttaccagtgc aatagatggg      720

tggggctttg gaattgagca cttcgccaga atctacagtc aaaaaattgg catcaaaaag      780

gaagttctta tgaaaacctt gtggggagat tactatataa atatgaaggc taaaaagatc      840

atgaagggtg atcaggccaa aggaaagaaa cctttatttg tacagttgat cctggaaaat      900

atatggagtt tgtatgatgc tgttttgaaa aaggacaaag acaaaattga taaaatagtg      960

acttctttag gattaaaaat tggagcccgg gaggcacgac attcagaccc taaagttcag     1020

atcaacgcca tttgcagtca gtggctaccc atatcccatg ctgttcttgc tatggtgtgt     1080

cagaaacttc ctagtcccct tgatattaca gctgagagag tggagagact gatgtgcaca     1140

ggatcacaaa cttttgactc ttttccacca gaaactcaag cactgaaagc agcttttatg     1200

aaatgtggaa gtgaggacac tgctccagtt attatatttg tttccaaaat gtttgcagtt     1260

gatgctaagg ccttgcctca gaataagcca aggcctctca ctcaagaaga aattgctcag     1320

agacgtgagc gtgcaagaca aaggcatgca gagaagcttg cagcagcaca gggacaggca     1380

cccttggagc ccacccaaga tgggagtgcc attgaaacat gtccaaaagg agaggagcca     1440

agaggtgacg agcaacaggt ggaaagtatg acccctaaac ctgtgctcca ggaagaaaac     1500

aaccaagagt cttttattgc atttgctcgg gtgttcagtg gtgtggctcg aagaggaaag     1560

aaaatttttg tcttggggcc caaatacagt cctcttgagt ttttacgaag ggtaccatta     1620

ggcttctcag ctccaccaga tggcctcccc caagtccccc acatggcata ctgtgctctg     1680

gaaaacctgt atcttctgat gggaagggaa ctggaatatc tagaggaggt acctccagga     1740

aatgtgctag gaataggagg ccttcaagat tttgtgctga aatctgcaac actgtgtagc     1800

ctgccatcct gcccaccatt tataccactc aacttcgaag ccactcctat tgtgagagtt     1860

gctgttgaac caaaacatcc aagtgaaatg cctcagctcg taaaaggaat gaaactgtta     1920

aaccaggctg atccctgtgt ccagatttta attcaggaaa cgggagagca cgttttagtc     1980

acagcaggag aagtccacct tcagcgatgc ctggatgact taaaagaaag gtttgcaaag     2040

attcatatca gtgtatctga acctattatt ccattcagag aaacaatcac aaaaccccca     2100

aaagttgaca tggtcaatga agaaataggc aaacagcaaa aagttgcagt catacaccaa     2160

atgaaagaag atcaaagcaa aatccctgaa ggaatccaag ttgactctga cgggctaatc     2220

accataacaa ctcccaataa acttgccacg ctcagtgttc gagccatgcc ccttccagaa     2280

gaagtcaccc agattctgga agaaaatagt gatttgattc gttctatgga gcagttgaca     2340

tcctctttga atgagggtga aaatactcac atgattcatc agaagaccca agagaaaatt     2400

tgggaattca aaggaaaact ggagcaacac ctaacaggga gaagatggag gaacattgtt     2460

gaccaaatct ggtcatttgg cccaagaaaa tgtgggccca acatactagt caataaaagt     2520

gaagattttc agaactcagt atggacaggt ccagctgaca aagcttcaaa agaagccagt     2580

agataccgag atttgggcaa tagcattgtg agtggcttcc aactagcaac cctctctggc     2640

cccatgtgtg aggagcctct catgggtgtc tgttttgttc tggaaaaatg ggacctaagt     2700

aaatttgagg aacaaggagc aagtgatctg gcaaaagagg gacaggagga aaatgaaacc     2760

tgttctggtg gaaatgaaaa ccaagagcta caagatggct gctctgaggc ctttgagaag     2820

aggacatcac agaaaggaga atctccactc actgactgct atggaccttt ctcaggacag     2880

ctaattgcca ccatgaaaga agcatgtcgc tatgcactgc aagtgaaacc tcagcgcctg     2940

atggcagcta tgtacacatg tgacatcatg gccactggtg atgttctcgg tcgagtctat     3000

gctgtcttgt caaagagaga aggtcgggta cttcaagaag aaatgaaaga agggacagac     3060

atgttcatca tcaaggctgt gctgcctgtt gctgaaagct ttggttttgc tgatgaaatc     3120

aggaagagga caagtggcct ggccagccca caactagtat tcagccattg ggagatcatt     3180

cccagtgacc ccttctgggt gccaactact gaggaggaat acttgcactt tggggagaag     3240

gctgactctg agaaccaagc ccggaagtac atgaacgcag tacgaaagcg gaaggggctt     3300

tatgtggaag aaaagattgt ggagcatgca gaaaagcaga ggacactcag caaaaataag     3360

tag                                                                   3363


<210>  1308
<211>  3663
<212>  DNA
<213>  homo sapiens

<400>  1308
atggggaaga aacagaaaaa caagagcgaa gacagcacca aggatgacat tgatcttgat       60

gccttggctg cagaaataga aggagctggt gctgccaaag aacaggagcc tcaaaagtca      120

aaagggaaaa agaaaaaaga gaaaaaaaag caggactttg atgaagatga tatcctgaaa      180

gaactggaag aattgtcttt ggaagctcaa ggcatcaaag ctgacagaga aactgttgca      240

gtgaagccaa cagaaaacaa tgaagaggaa ttcacctcaa aagataaaaa aaagaaagga      300

cagaagggca aaaaacagag ttttgatgat aatgatagcg aagaattgga agataaagat      360

tcaaaatcaa aaaagactgc aaaaccgaaa gtggaaatgt actctgggag tgatgatgat      420

gatgatttta acaaacttcc taaaaaagct aaagggaaag ctcaaaaatc aaataagaag      480

tgggatgggt cagaggagga tgaggataac agtaaaaaaa ttaaagagcg ttcaagaata      540

aattcttctg gtgaaagtgg tgatgaatca gatgaatttt tgcaatctag aaaaggacag      600

aaaaaaaatc agaaaaacaa gccaggtcct aacatagaaa gtgggaatga agatgatgac      660

gcctccttca aaattaagac agtggcccaa aagaaggcag aaaagaagga gcgcgagaga      720

aaaaagcgag atgaagaaaa agcgaaactg cggaagctga aagaaaaaga agagttagaa      780

acaggtaaaa aggatcagag taaacaaaag gaatctcaaa ggaaatttga agaagaaact      840

gtaaaatcca aagtgactgt tgatactgga gtaattcctg cctctgaaga gaaagcagag      900

actcccacag ctgcagaaga tgacaatgaa ggagacaaaa agaagaaaga taagaagaaa      960

aagaaaggag aaaaggaaga aaaagagaaa gagaagaaaa aaggacctag caaagccact     1020

gttaaagcta tgcaagaagc tctggctaag cttaaagagg aagaagaaag acagaagaga     1080

gaagaggaag aacgtataaa acggcttgaa gaattagaag ccaagcgtaa agaagaggaa     1140

cgattggaac aagaaaaaag agaaaggaaa aagcaaaaag aaaaagaaag aaaagaacgc     1200

ttgaaaaaag aagggaaact tttaactaaa tcccagagag aagccagagc cagagccgaa     1260

gctactctta aactgctaca agctcagggt gttgaagtgc catcaaaaga ctctttgcca     1320

aagaagaggc caatttatga agataaaaag aggaaaaaaa taccacagca gctagaaagt     1380

aaagaagtgt ctgaatcaat ggaattatgt gctgctgtag aagttatgga acaaggagta     1440

ccagaaaagg aagagacacc acctcctgtt gaaccagaag aagaagaaga tactgaggat     1500

gctggattgg atgattggga agctatggcc agtgatgagg agacagaaaa agtagaagga     1560

aacaaagttc atatagaagt aaaagaaaac cctgaagagg aggaggagga ggaagaagag     1620

gaagaagaag atgaagaaag tgaagaagag gaggaagagg agggagaaag tgaaggcagt     1680

gaaggtgatg aggaagatga aaaggtgtca gatgagaagg attcagggaa gacattagat     1740

aaaaagccaa gtaaagaaat gagctcagat tctgaatatg actctgatga tgatcggact     1800

aaagaagaaa gggcttatga caaagcaaaa cggaggattg agaaacggcg acttgaacat     1860

agtaaaaatg taaacaccga aaagctaaga gcccctatta tctgcgtact tgggcatgtg     1920

gacacaggga agacaaaaat tctagataag ctccgtcaca cacatgtaca agatggtgaa     1980

gcaggtggta tcacacaaca aattggggcc accaatgttc ctcttgaagc tattaatgaa     2040

cagactaaga tgattaaaaa ttttgataga gagaatgtac ggattccagg aatgctaatt     2100

attgatactc ctgggcatga atctttcagt aatctgagaa atagaggaag ctctctttgt     2160

gacattgcca ttttagttgt tgatattatg catggtttgg agccccagac aattgagtct     2220

atcaaccttc tcaaatctaa aaaatgtccc ttcattgttg cactcaataa gattgatagg     2280

ttatatgatt ggaaaaagag tcctgactct gatgtggctg ctactttaaa gaagcagaaa     2340

aagaatacaa aagatgaatt tgaggagcga gcaaaggcta ttattgtaga atttgcacag     2400

cagggtttga atgctgcttt gttttatgag aataaagatc cccgcacttt tgtgtctttg     2460

gtacctacct ctgcacatac tggtgatggc atgggaagtc tgatctacct tcttgtagag     2520

ttaactcaga ccatgttgag caagagactt gcacactgtg aagagctgag agcacaggtg     2580

atggaggtta aagctctccc ggggatgggc accactatag atgtcatctt gatcaatggg     2640

cgtttgaagg aaggagatac aatcattgtt cctggagtag aagggcccat tgtaactcag     2700

attcgaggcc tcctgttacc tcctcctatg aaggaattac gagtgaagaa ccagtatgaa     2760

aagcataaag aagtagaagc agctcagggg gtaaagattc ttggaaaaga cctggagaaa     2820

acattggctg gtttacccct ccttgtggct tataaagaag atgaaatccc tgttcttaaa     2880

gatgaattga tccatgagtt aaagcagaca ctaaatgcta tcaaattaga agaaaaagga     2940

gtctatgtcc aggcatctac actgggttct ttggaagctc tactggaatt tctgaaaaca     3000

tcagaagtgc cctatgcagg aattaacatt ggcccagtgc ataaaaaaga tgttatgaag     3060

gcttcagtga tgttggaaca tgaccctcag tatgcagtaa ttttggcctt cgatgtgaga     3120

attgaacgag atgcacaaga aatggctgat agtttaggag ttagaatttt tagtgcagaa     3180

attatttatc atttatttga tgcctttaca aaatatagac aagactacaa gaaacagaaa     3240

caagaagaat ttaagcacat agcagtattt ccctgcaaga taaaaatcct ccctcagtac     3300

atttttaatt ctcgagatcc gatagtgatg ggggtgacgg tggaagcagg tcaggtgaaa     3360

caggggacac ccatgtgtgt cccaagcaaa aattttgttg acatcggaat agtaacaagt     3420

attgaaataa accataaaca agtggatgtt gcaaaaaaag gacaagaagt ttgtgtaaaa     3480

atagaaccta tccctggtga gtcacccaaa atgtttggaa gacattttga agctacagat     3540

attcttgtta gtaagatcag ccggcagtcc attgatgcac tcaaagactg gttcagagat     3600

gaaatgcaga agagtgactg gcagcttatt gtggagctga agaaagtatt tgaaatcatc     3660

taa                                                                   3663


<210>  1309
<211>  1332
<212>  DNA
<213>  homo sapiens

<400>  1309
atggtgcgcg gcaggatctc ccggctctcg gtccgggacg tgcgcttccc cacgtcgctt       60

gggggccacg gcgcggacgc catgcacacg gaccctgact actcggctgc ctatgtcgtc      120

atagaaactg atgcagaaga tggaatcaag gggtgtggaa ttaccttcac tctgggaaaa      180

ggcactgaag ttgttgtctg tgctgtgaat gccctcgccc accatgtgct caacaaggac      240

ctcaaggaca ttgttggtga cttcagaggc ttctataggc agctcacaag tgatgggcag      300

ctcagatgga ttggtccaga aaagggcgtg gtgcacctgg cgacagcggc cgtcctaaac      360

gcggtgtggg acttgtgggc caagcaggag ggaaagcctg tctggaagtt acttgtggac      420

atggatccca ggatgctggt atcctgcata gatttcaggt acatcactga tgtcctgact      480

gaggaggatg ccctagaaat actgcagaaa ggtcaaattg gtaaaaaaga aagagagaag      540

caaatgctgg cacaaggata ccctgcttac acgacatcgt gcgcctggct ggggtactca      600

gatgacacgt tgaagcagct ctgtgcccag gcgctgaagg atggctggac caggtttaaa      660

gtaaaggtgg gtgctgatct ccaggatgac atgcgaagat gccaaatcat ccgagacatg      720

attggaccgg aaaagacttt gatgatggat gccaaccagc gctgggatgt gcctgaggcg      780

gtggagtgga tgtccaagct ggccaagttc aagccattgt ggattgagga gccaacctcc      840

cctgatgaca ttctggggca cgccaccatt tccaaggcac tggtcccatt aggaattggc      900

attgccacag gagaacagtg ccacaataga gtgatattta agcaactcct acaggcgaag      960

gccctgcagt tcctccagat tgacagttgc agactgggca gtgtcaatga gaacctctca     1020

gtattgctga tggccaaaaa gtttgaaatt cctgtttgcc cccatgctgg tggagttggc     1080

ctctgtgaac tggtgcagca cctgattata tttgactaca tatcagtttc tgcaagcctt     1140

gaaaataggg tgtgtgagta tgttgaccac ctgcatgagc atttcaagta tcccgtgatg     1200

atccagcggg cttcctacat gcctcccaag gatcccggct actcaacaga aatgaaggag     1260

gaatctgtaa agaaacacca gtatccagat ggtgaagttt ggaagaaact ccttcctgct     1320

caagaaaatt aa                                                         1332


<210>  1310
<211>  1533
<212>  DNA
<213>  homo sapiens

<400>  1310
atggaagata caaaggagtc taacgtgaag acattttgct ccaagaatat cctagccatc       60

cttggcttct cctctatcat agctgtgata gctttgcttg ctgtggggtt gacccagaac      120

aaagcattgc cagaaaacgt taagtatggg attgtgctgg atgcgggttc ttctcacaca      180

agtttataca tctataagtg gccagcagaa aaggagaatg acacaggcgt ggtgcatcaa      240

gtagaagaat gcagggttaa aggtcctgga atctcaaaat ttgttcagaa agtaaatgaa      300

ataggcattt acctgactga ttgcatggaa agagctaggg aagtgattcc aaggtcccag      360

caccaagaga cacccgttta cctgggagcc acggcaggca tgcggttgct caggatggaa      420

agtgaagagt tggcagacag ggttctggat gtggtggaga ggagcctcag caactacccc      480

tttgacttcc agggtgccag gatcattact ggccaagagg aaggtgccta tggctggatt      540

actatcaact atctgctggg caaattcagt cagaaaacaa ggtggttcag catagtccca      600

tatgaaacca ataatcagga aacctttgga gctttggacc ttgggggagc ctctacacaa      660

gtcacttttg taccccaaaa ccagactatc gagtccccag ataatgctct gcaatttcgc      720

ctctatggca aggactacaa tgtctacaca catagcttct tgtgctatgg gaaggatcag      780

gcactctggc agaaactggc caaggacatt caggttgcaa gtaatgaaat tctcagggac      840

ccatgctttc atcctggata taagaaggta gtgaacgtaa gtgaccttta caagaccccc      900

tgcaccaaga gatttgagat gactcttcca ttccagcagt ttgaaatcca gggtattgga      960

aactatcaac aatgccatca aagcatcctg gagctcttca acaccagtta ctgcccttac     1020

tcccagtgtg ccttcaatgg gattttcttg ccaccactcc agggggattt tggggcattt     1080

tcagcttttt actttgtgat gaagttttta aacttgacat cagagaaagt ctctcaggaa     1140

aaggtgactg agatgatgaa aaagttctgt gctcagcctt gggaggagat aaaaacatct     1200

tacgctggag taaaggagaa gtacctgagt gaatactgct tttctggtac ctacattctc     1260

tccctccttc tgcaaggcta tcatttcaca gctgattcct gggagcacat ccatttcatt     1320

ggcaagatcc agggcagcga cgccggctgg actttgggct acatgctgaa cctgaccaac     1380

atgatcccag ctgagcaacc attgtccaca cctctctccc actccaccta tgtcttcctc     1440

atggttctat tctccctggt ccttttcaca gtggccatca taggcttgct tatctttcac     1500

aagccttcat atttctggaa agatatggta tag                                  1533


<210>  1311
<211>  2751
<212>  DNA
<213>  homo sapiens

<400>  1311
atggagtcag ggcagccggc tcgacggatt gccatggcgc cgctgctgga gtacgagcga       60

cagctggtgc tggaactgct cgacactgac gggctagtag tgtgcgcccg cgggctcggc      120

gcggaccggc tcctctacca ctttctccag ctgcactgcc acccagcctg cctggtgctg      180

gtgctcaaca cgcagccggc cgaggaggag tattttatca atcagctgaa gatagaagga      240

gttgaacacc tccctcgccg tgtaacaaat gaaatcacaa gcaacagtcg ctatgaagtt      300

tacacacaag gtggtgttat atttgcgaca agtaggatac ttgtggttga cttcttgact      360

gatagaatac cttcagattt aattactggc atcttggtgt atagagccca cagaataatc      420

gagtcttgtc aagaagcatt catcttgcgc ctctttcgcc agaaaaacaa acgtggtttt      480

attaaagctt tcacagacaa tgctgttgcc tttgatactg gtttttgtca tgtggaaaga      540

gtgatgagaa atctttttgt gaggaaactg tatctgtggc caaggttcca tgtagcagta      600

aactcatttt tagaacagca caaacctgaa gttgtagaaa tccatgtttc tatgacacct      660

accatgcttg ctatacagac tgctatactg gacattttaa atgcatgtct aaaggaacta      720

aaatgccata acccatcgct tgaagtggaa gatttatctt tagaaaatgc tattggaaaa      780

ccttttgaca agacaatccg ccattatctg gatcctttgt ggcaccagct tggagccaag      840

actaaatcct tagttcagga tttgaagata ttacgaactt tgctgcagta tctctctcag      900

tatgattgtg tcacatttct taatcttctg gaatctctga gagcaacgga aaaagctttt      960

ggtcagaatt caggttggct gtttcttgac tccagcacct cgatgtttat aaatgctcga     1020

gcaagggttt atcatcttcc agatgccaaa atgagtaaaa aagaaaaaat atctgaaaaa     1080

atggaaatta aagaagggga agaaacaaaa aaggaactgg tcctagaaag caacccaaag     1140

tgggaggcac tgactgaagt attaaaagaa attgaggcag aaaataagga gagtgaagct     1200

cttggtggtc caggtcaagt actgatttgt gcaagtgatg accgaacatg ttcccagctg     1260

agagactata tcactcttgg agcggaggcc ttcttattga ggctctacag gaaaaccttt     1320

gagaaggata gcaaagctga agaagtctgg atgaaattta ggaaggaaga cagttcaaag     1380

agaattagga aatctcacaa aagacctaaa gacccccaaa acaaagaacg ggcttctacc     1440

aaagaaagaa ccctcaaaaa gaaaaaacgg aagttgacct taactcaaat ggtaggaaaa     1500

cctgaagaac tggaagagga aggagatgtc gaggaaggat atcgtcgaga aataagcagt     1560

agcccagaaa gctgcccgga agaaattaag catgaagaat ttgatgtaaa tttgtcatcg     1620

gatgctgctt tcggaatcct gaaagaaccc ctcactatca tccatccgct tctgggttgc     1680

agcgacccct atgctctgac aagggtacta catgaagtgg agccaagata cgtggttctt     1740

tatgacgcag agctaacctt tgttcggcag cttgaaattt acagggcgag taggcctggg     1800

aaacctctga gggtttactt tcttatatac ggaggttcaa ctgaggaaca acgctatctc     1860

actgctttgc ggaaagaaaa ggaagctttt gaaaaactca taagggaaaa agcaagcatg     1920

gttgtccctg aagaaagaga aggcagagat gaaacaaact tagacctagt aagaggcaca     1980

gcatctgcag atgtttccac tgacactcgg aaagccggtg gccaggaaca gaatggtaca     2040

cagcaaagca tagttgtgga tatgcgtgaa tttcgaagtg agcttccatc tctgatccat     2100

cgtcggggca ttgacattga acccgtgact ttagaggttg gagattacat cctcactcca     2160

gaaatgtgcg tggagcgcaa gagtatcagt gatttaatcg gctctttaaa taacggccgc     2220

ctctacagcc agtgcatctc catgtcccgc tactacaagc gtcccgtgct tctgattgag     2280

tttgacccta gcaagccttt ctctctcact tcccgaggtg ccttgtttca ggagatctcc     2340

agcaatgaca ttagttccaa actcactctt cttacacttc acttccccag actacggatt     2400

ctctggtgcc cctctcctca tgcaacggcg gagttgtttg aggagctgaa acaaagcaag     2460

ccacagcctg atgcggcgac agcactggcc attacagcag attctgaaac ccttcccgag     2520

tcagagaagt ataatcctgg tccccaagac ttcttgttaa aaatgccagg ggtgaatgcc     2580

aaaaactgcc gctccttgat gcaccacgtt aagaacatcg cagaattagc agccctgtca     2640

caagacgagc tcacgagtat tctggggaat gctgcaaatg ccaaacagct ttatgatttc     2700

attcacacct cttttgcaga agtcgtatca aaaggaaaag ggaaaaagtg a              2751


<210>  1312
<211>  2556
<212>  DNA
<213>  homo sapiens

<400>  1312
atgtcatcca aacaagaaat aatgagtgac cagcggttta gacgggttgc aaaggacccg       60

agattttggg aaatgccaga aaaggatcga aaagtcaaaa ttgacaagag atttcgagcc      120

atgtttcatg acaagaagtt caagttgaac tatgccgtgg ataaaagagg gcgccccatt      180

agccatagca ctacagagga tttgaagcgt ttttacgacc tttcagattc tgattccaat      240

ctctctggtg aagatagcaa agcattgagt caaaagaaaa taaagaagaa aaaaacccag      300

actaaaaaag aaatcgattc aaaaaatcta gttgagaaaa agaaagaaac caagaaggct      360

aatcacaagg gttctgaaaa taaaactgat ttagataatt ctataggaat taaaaaaatg      420

aaaacctcat gtaaatttaa gatagattca aacataagtc cgaagaagga tagcaaagaa      480

tttacacaaa aaaataagaa agagaaaaaa aacattgttc aacatactac agactcttct      540

ctcgaagaaa aacaaaggac attagactca ggcacctctg aaattgtgaa atctcccaga      600

atcgagtgtt ctaagacaag aagagaaatg caatcagtgg ttcaactcat aatgacaaga      660

gacagtgatg gttatgaaaa ctcaacagat ggtgaaatgt gtgacaaaga tgctctggag      720

gaagattcag aaagcgttag tgaaatagga agtgatgagg aatctgaaaa tgaaattaca      780

agtgttggta gagcttcagg tgatgacgat ggaagtgaag atgatgaaga ggaggatgaa      840

gatgaagagg aggatgaaga tgaggatagt gaggatgatg ataaaagtga cagtggccct      900

gatcttgcaa ggggtaaagg aaatatagaa actagttctg aagatgaaga tgatacggca      960

gatttgtttc cagaagaatc tggttttgag catgcttgga gagaattaga taaagatgct     1020

cctcgtgctg atgagattac acgtcgatta gcagtttgta acatggactg ggatagatta     1080

aaggcaaaag atttgctggc tctgttcaat tcatttaaac ccaaaggagg tgtaatattt     1140

tccgtcaaga tatatccttc agaatttgga aaggagagga tgaaggaaga gcaagttcaa     1200

ggaccagtag agctattaag tattcctgaa gatgccccag aaaaagactg gacgtctaga     1260

gaaaaattga gagattatca attcaaacga ctgaagtact attatgcagt agtagactgt     1320

gattctccgg aaacagctag taaaatttat gaggattgtg atggcctgga atttgaaagt     1380

agttgttctt tcatagatct aaggtttata ccagatgata ttacttttga tgatgagcct     1440

aaggatgtag cctcagaagt gaatttaaca gcatataaac caaaatattt cacttctgct     1500

gcaatgggaa catcaacggt ggaaatcact tgggatgaga ctgatcatga aagaattaca     1560

atgctcaaca ggaagtttaa aaaggaagag cttttggaca tggattttca agcctactta     1620

gcttcctcta gtgaagatga agaggagata gaagaggagc tacaaggtga tgatggagtc     1680

aatgtagaag aagatgggaa aacaaagaaa agtcagaagg atgatgaaga acaaattgct     1740

aaatacaggc agctcttgca ggttattcaa gaaaaagaaa agaaaggcaa agaaaatgat     1800

atggaaatgg aaattaaatg ggttccaggt cttaaagaaa gtgcagaaga gatggtcaaa     1860

aacaaattgg aaggaaagga taaactgacc ccttgggaac aatttttaga gaagaagaaa     1920

gagaaaaaaa gactgaaaag gaaacagaag gctcttgctg aagaggccag tgaagaggaa     1980

cttccctctg atgttgattt gaatgaccca tactttgctg aagaagttaa acaaataggt     2040

ataaataaaa aatcggtaaa atctgcaaaa gatggcacat ctccagaaga agaaattgaa     2100

atagaaagac aaaaggctga aatggctttg cttatgatgg atgaggacga ggacagtaag     2160

aaacacttca attacaacaa gattgtggag caccagaatc tgagcaaaaa gaagaaaaag     2220

cagctcatga aaaagaagga attaatagag gatgactttg aggtaaatgt taacgatgca     2280

cggtttcagg caatgtacac ttcccacttg ttcaatttgg acccctcaga tcccaatttc     2340

aagaaaacaa aagctatgga aaaaatcctt gaggagaagg cccggcaaag agaacggaaa     2400

gaacaagaac ttactcaggc aataaagaaa aaagagagtg agattgaaaa ggaatcacaa     2460

aggaagtcca ttgatcctgc tttgtcaatg ttgattaaat ctataaaaac caaaacagag     2520

cagtttcaag caagaaaaaa gcaaaaagtc aaataa                               2556


<210>  1313
<211>  1962
<212>  DNA
<213>  homo sapiens

<400>  1313
atgattcccc cacaggaggc atccgctcga cggcgggaga ttgaggacaa gctgaagcag       60

gaggaggaga ctctgtcctt catccgagac agcctggaga agagcgacca gctcactaag      120

aacatggtgt ctatcttatc atcctttgag agccgcctta tgaagctgga gaactccatc      180

atccctgtgc acaagcagac ggagaatctg cagcggctgc aggagaatgt tgagaagacg      240

ctgtcctgcc tggaccatgt catcagctac taccatgtgg ccagtgacac tgagaagatc      300

atcagagagg gccccacagg taggctggaa gagtacctgg gaagcatggc caagattcag      360

aaggcagtgg agtatttcca ggacaacagc ccagacagcc cggaactcaa caaagtgaaa      420

ctgctctttg agcgcgggaa ggaggccctg gagtccgaat ttcgcagcct gatgacgcgg      480

cacagtaagg tcgtctcgcc cgtgctcatc ttggatctga tcagtggtga cgatgatctg      540

gaggcccagg aggacgtgac cctggagcac ctgcccgaga gcgtgctcca ggatgtcatt      600

cgcatctccc gctggctggt ggaatatggc cgcaaccaag atttcatgaa cgtctactac      660

cagatacgct ccagccagct ggaccgctcc atcaaaggac tgaaggagca tttccataag      720

agcagttctt cctctggggt tccctactcc cctgctatcc ccaacaagag gaaagacaca      780

cctaccaaga agccagtcaa gcggccaggg agagatgaca tgctggacgt ggagaccgat      840

gcctacatcc actgcgtcag tgccttcgtc aagctggcgc agagcgagta ccagctgctg      900

gccgacatca tccccgagca ccaccagaag aagaccttcg actccctgat acaggatgcc      960

ctggatgggc tgatgcttga aggggagaac atcgtgtctg ctgcccggaa ggccattgtg     1020

cgacacgact tctccacggt gctcaccgtc ttccccatcc tgcgacacct caagcagacc     1080

aagcctgagt ttgaccaggt gctccagggc acggctgcca gcacaaagaa caagctgcct     1140

ggcctcatca catccatgga gaccatcggt gccaaagcgc tggaggactt cgcagacaac     1200

atcaagaatg acccggacaa ggagtacaac atgccgaagg acggcaccgt acacgagctc     1260

accagcaatg ccatcctctt cctgcagcag cttttggact tccaggagac ggcaggcgcc     1320

atgctggcct cccaagagac cagctcttcg gccaccagct acagctctga gttcagcaag     1380

cggctgctaa gcacctatat ctgtaaagtg ctgggcaacc tgcagttgaa cttgctgagc     1440

aagtccaagg tgtacgagga cccagctctg agcgccatct tcctgcacaa caactacaat     1500

tacatcctca agtccctgga gaagtctgaa ctgatccagc tggtggcagt gacacagaag     1560

actgctgagc gctcctaccg ggagcacatt gagcagcaga tccagaccta ccagcgcagc     1620

tggttaaagg tgactgatta catcgcagag aagaatctac ctgtgttcca gccgggagtc     1680

aagctccggg acaaggagcg gcagattatc aaggagcgtt ttaagggctt caatgatggc     1740

ctcgaagaac tgtgcaaaat ccagaaggcc tgggctattc cagacacaga gcagagggac     1800

aggattcgcc aggcccagaa gaccattgtc aaggagacct acggggcctt tctacagaag     1860

tttggcagcg tgcccttcac caagaacccg gagaagtaca tcaagtacgg ggtggagcag     1920

gtgggcgaca tgatcgatcg ccttttcgac acctctgcct ga                        1962


<210>  1314
<211>  2760
<212>  DNA
<213>  homo sapiens

<400>  1314
atgacaggct ataccatgct gcggaatggg ggcgcgggga acggaggtca gacctgcatg       60

ctgcgctggt ccaaccgcat ccgcctcacg tggctcagct tcacgctctt tgtcatcctg      120

gtcttcttcc cgctcatcgc ccactattac ctcaccactc tggatgaggc tgatgaggca      180

ggcaagcgga tttttggtcc ccgggtgggg aacgagctgt gcgaggtgaa gcacgtgctg      240

gatctgtgcc gcatccggga gtcggtgagt gaagagctcc tgcagctgga ggccaagcgc      300

caagagctga acagcgagat cgccaagctg aatctgaaga tcgaagcctg taagaagagc      360

attgagaacg ccaagcagga cctgctccag ctcaagaatg tcatcagcca gaccgagcat      420

tcctacaagg agctcatggc ccagaaccag cccaagctgt ccctgcccat ccgactgctc      480

ccagagaagg acgatgccgg cctccctccc ccgaaggcca ctcggggctg ccggctacac      540

aactgctttg attattctcg ttgccctctc acctctggct tcccggtcta cgtctatgac      600

agtgaccagt ttgtctttgg cagctacctg gatcccttgg tcaagcaggc ttttcaggcg      660

acagcacgag ctaacgttta tgttacagaa aatgcagaca tcgcctgcct ttacgtgata      720

ctagtgggag agatgcagga gccggtggtg ctgcggcctg ctgagctgga gaagcagttg      780

tattccctgc cacactggcg gacggatgga cacaaccatg tcatcatcaa tctgtcacgt      840

aagtcagata cacagaacct tctctataac gtcagtactg gccgtgccat ggtggcccag      900

tccaccttct acactgtcca gtacagacct ggctttgact tggtcgtatc accgctggtc      960

catgccatgt ctgagcccaa cttcatggaa atcccaccac aggtgccggt gaagcggaaa     1020

tatctcttca ccttccaggg cgagaagatt gagtctctga ggtctagcct tcaggaggcc     1080

cgctccttcg aagaggaaat ggagggcgac cctcccgccg actacgatga ccggatcatt     1140

gccaccctga aggcggtgca ggacagcaag ctggatcagg tcctggtgga attcacctgc     1200

aaaaaccagc ccaaacccag cctgccgact gagtgggcac tgtgtggaga gcgggaggac     1260

cgcttggaat tgctgaagct ctccaccttc gccctcatca ttacccccgg ggaccctcgc     1320

ttggttattt cctctgggtg tgcaacacgg ctcttcgaag ccctggaagt cggtgccgtc     1380

ccggtggtgc tgggggagca ggtccagctt ccctaccagg acatgctgca gtggaacgag     1440

gcggccctgg tggtgccaaa gcctcgtgtt accgaggttc atttcctgct cagaagcctc     1500

tccgatagtg acctcctggc tatgaggcgg caaggccgct ttctctggga gacttacttc     1560

tccactgctg acagtatttt taataccgtg ctggctatga ttaggactcg catccagatc     1620

ccagccgctc ccatccggga agaggcggca gctgagatcc cccaccgttc aggcaaggcg     1680

gctggaactg accccaacat ggctgacaac ggggacctgg acctggggcc agtggagacg     1740

gagccgccct acgcctcacc cagatacctc cgcaatttca ctctgactgt cactgacttt     1800

taccgcagct ggaactgtgc tccagggcct ttccatcttt tcccccacac tccctttgac     1860

cctgtgttgc cctcagaggc caaattcttg ggctcaggga ctggctttcg gcctattggt     1920

ggtggagctg ggggttctgg caaggaattt caggcagcgc ttggaggcaa tgttccccga     1980

gagcagttca cggtggtgat gttgacttat gagcgggagg aagtgcttat gaactcttta     2040

gagaggctga atggcctccc ttacctgaac aaggtcgtgg tggtgtggaa ttctcccaag     2100

ctgccatcag aggaccttct gtggcctgac attggcgtcc ccatcatggt ggtccgtact     2160

gagaagaaca gtttgaacaa ccgattctta ccctggaatg aaattgagac agaggccatc     2220

ctgtccattg atgacgatgc tcacctccgc catgacgaaa tcatgtttgg gttccgggtg     2280

tggagagaag ctcgggaccg catcgtgggc ttccctggcc gttaccacgc atgggacatc     2340

ccccatcagt cctggctcta caactccaac tactcctgtg agctgtccat ggtgctgaca     2400

ggtgctgcct tctttcacaa gtattatgcc tacctgtatt cttatgtgat gccccaggcc     2460

atccgggaca tggtggatga atacatcaac tgtgaggaca ttgccatgaa cttccttgtc     2520

tcccacatca ctcggaagcc ccccatcaag gtgacctcac ggtggacatt ccgatgccca     2580

ggatgccctc aggccctgtc tcatgatgac tcccacttcc acgagcggca caagtgcatc     2640

aacttcttcg tgaaggtgta cggctacatg cccctcctgt acacgcagtt cagggtggat     2700

tctgtgctct tcaagacacg cctgccccat gacaagacca agtgcttcaa gttcatctag     2760


<210>  1315
<211>  2133
<212>  DNA
<213>  homo sapiens

<400>  1315
atgttgacaa ctttgaagcc atttggaagt gtttcagtgg agagcaaaat gaataacaaa       60

gcgggctcct ttttctggaa ccttagacaa ttcagtacat tagtttcaac aagcagaact      120

atgaggctat gttgtttggg actttgcaaa ccaaaaatag ttcattcaaa ctggaacatt      180

ttaaataact ttcataacag aatgcaatca actgatatca ttagatatct ctttcaggat      240

gcattcattt ttaaatcaga tgttggcttt caaacaaagg gcataagcac tctaacagcc      300

cttagaattg aaagactact ttatgctaaa agactgtttt ttgactcaaa gcagtctctt      360

gtccctgttg ataaatctga tgatgaattg aagaaagtaa accttaatca tgaagtctcc      420

aatgaagatg ttcttaccaa ggaaacaaaa ccaaaccgta tcagcagtag aaaactgtct      480

gaggaatgta attccctgag tgatgtgtta gatgcatttt caaaagcgcc cacatttcct      540

agtagcaact atttcacagc aatgtggaca attgccaaaa gactgtctga tgaccagaag      600

cgctttgaaa aacgactgat gtttagccac cctgcattta atcagctctg tgaacatatg      660

atgagagaag ccaagatcat gcagtataag tacctactgt tcagtcttca cgccatagtg      720

aagcttggaa tccctcagaa cactattttg gtgcagactt tgctgagggt gacccaggaa      780

cgtatcaatg agtgtgatga gatatgcctt tcagttttgt caactgtttt agaggcaatg      840

gaaccatgca agaatgttca tgttctacga acgggattca gaatactagt tgatcagcaa      900

gtttggaaaa tagaagatgt cttcacatta caagttgtga tgaagtgtat tggaaaagat      960

gcaccgattg ctcttaagag gaaactggag atgaaagcct tgagggaatt agacagattt     1020

tctgttttga atagccaaca catgtttgaa gtactagctg ccatgaatca ccgatctctt     1080

atactcctgg atgaatgcag taaggtggtc ctagataata tccatgggtg tcctttaaga     1140

ataatgatca acatattgca gtcctgcaaa gacctccagt accataattt ggatctcttc     1200

aagggacttg cagattatgt ggctgcaact ttcgacatct ggaagttcag aaaagttctt     1260

tttatcctca ttttatttga aaaccttggc tttcgacctg ttggtttaat ggacctgttt     1320

atgaagagaa tagtagagga tcctgaatcc ctaaacatga aaaacattct atctattctt     1380

catacttact cttctctcaa tcatgtctac aaatgccaga acaaagaaca gttcgtggaa     1440

gttatggcta gtgctctgac tggttatctt cacactattt cttctgaaaa cttattggat     1500

gcagtatatt cattttgctt gatgaattac tttcccctgg ctccttttaa tcagcttctg     1560

caaaaagaca tcatcagtga gctgctgaca tcagatgaca tgaagaatgc ttacaagctg     1620

catactttgg atacttgtct aaaacttgat gatactgtct atctgaggga catagccttg     1680

tcactcccac agctgccgcg ggagctgcca tcgtcacata caaatgcaaa ggtggcagag     1740

gtgctgagca gccttctggg aggtgaagga cacttctcaa aggatgtgca cttgccacac     1800

aattatcata ttgattttga aatcagaatg gacactaaca ggaatcaagt gctaccactt     1860

tctgatgtgg atacaacttc tgctacagat attcaaagag tagctgtgct atgtgtttcc     1920

agatctgctt attgtttggg ttcaagccac cccagaggat tccttgctat gaaaatgcgg     1980

catttgaatg caatgggttt tcatgtgatc ttggtcaata actgggagat ggacaaacta     2040

gagatggaag atgcagtcac atttttgaag actaaaatct attcagtaga agctcttcct     2100

gttgctgctg taaatgtgca aagcacacaa taa                                  2133


<210>  1316
<211>  597
<212>  DNA
<213>  homo sapiens

<400>  1316
atggggaagc aaaagaaaac aaggaagtat gcgaccatga agcgaatgct tagtctcaga       60

gatcagaggc ttaaagaaaa ggatagatta aaacctaaaa agaaagaaaa gaaggatccc      120

agcgcattaa aggaaagaga agttccccaa cacccttcct gcttattttt ccaatataat      180

acacagctgg gcccacctta ccacatcctc gttgatacca actttatcaa cttttccata      240

aaagccaaac tggacttagt gcagtcaatg atggactgtc tgtatgccaa gtgtatccca      300

tgtataaccg attgtgtaat ggctgaaatt gagaaattgg ggcagaagta tcgagtggct      360

ctaaggattg ccaaggatcc aagatttgaa cgattaccat gtacacacaa aggaacctat      420

gcagatgact gcttagtaca gagagtaact cagcataagt gttacattgt ggccacagtt      480

gaccgggacc tgaaaagaag aatccgtaag attcctggag ttcctatcat gtacatttct      540

aaccatagat acaacattga acggatgcca gatgattatg gagcccctcg attctaa         597


<210>  1317
<211>  1239
<212>  DNA
<213>  homo sapiens

<400>  1317
atgacggatc tatactacct cagtcagaca gatggagcag gtgattggcg ggaaaaagag       60

gccaaagatc tgacagaact ggttcagcgg agaataacat atcttcagaa tcccaaggac      120

tgcagcaaag ccaaaaagct ggtgtgtaat atcaacaaag gctgtggcta tggctgtcag      180

ctccatcatg tggtctactg cttcatgatt gcatatggca cccagcgaac actcatcttg      240

gaatctcaga attggcgcta tgctactggt ggatgggaga ctgtatttag gcctgtaagt      300

gagacatgca cagacagatc tggcatctcc actggacact ggtcaggtga agtgaaggac      360

aaaaatgttc aagtggtcga gcttcccatt gtagacagtc ttcatccccg tcctccatat      420

ttacccttgg ctgtaccaga agacctcgca gatcgacttg tacgagtgca tggtgaccct      480

gcagtgtggt gggtgtctca gtttgtcaaa tacttgatcc gcccacagcc ttggctagaa      540

aaagaaatag aagaagccac caagaagctt ggcttcaaac atccagttat tggagtccat      600

gtcagacgca cagacaaagt gggaacagaa gctgccttcc atcccattga agagtacatg      660

gtgcatgttg aagaacattt tcagcttctt gcacgcagaa tgcaagtgga caaaaaaaga      720

gtgtatttgg ccacagatga cccttcttta ttaaaggagg caaaaacaaa gtaccccaat      780

tatgaattta ttagtgataa ctctatttcc tggtcagctg gactgcacaa tcgatacaca      840

gaaaattcac ttcgtggagt gatcctggat atacattttc tctctcaggc agacttccta      900

gtgtgtactt tttcatccca ggtctgtcga gttgcttatg aaattatgca aacactacat      960

cctgatgcct ctgcaaactt ccattcttta gatgacatct actattttgg gggccagaat     1020

gcccacaatc aaattgccat ttatgctcac caaccccgaa ctgcagatga aattcccatg     1080

gaacctggag atatcattgg tgtggctgga aatcattggg atggctattc taaaggtgtc     1140

aacaggaaat tgggaaggac gggcctatat ccctcctaca aagttcgaga gaagatagaa     1200

acggtcaagt accccacata tcctgaggct gagaaataa                            1239


<210>  1318
<211>  1401
<212>  DNA
<213>  homo sapiens

<400>  1318
atggtgatgg agaagcctag tcccctgctg gtcgggcggg aatttgtgag acagtattac       60

acactgctga accaggcccc agacatgctg catagatttt atggaaagaa ctcttcttat      120

gtccatgggg gattggattc aaatggaaag ccagcagatg cagtctacgg acagaaagaa      180

atccacagga aagtgatgtc acaaaacttc accaactgcc acaccaagat tcgccatgtt      240

gatgctcatg ccacgctaaa tgatggtgtg gtagtccagg tgatggggct tctctctaac      300

aacaaccagg ctttgaggag attcatgcaa acgtttgtcc ttgctcctga ggggtctgtt      360

gcaaataaat tctatgttca caatgatatc ttcagatacc aagatgaggt ctttggtggg      420

tttgtcactg agcctcagga ggagtctgaa gaagaagtag aggaacctga agaaagacag      480

caaacacctg aggtggtacc tgatgattct ggaactttct atgatcaggc agttgtcagt      540

aatgacatgg aagaacattt agaggagcct gttgctgaac cagagcctga tcctgaacca      600

gaaccagaac aagaacctgt atctgaaatc caagaggaaa agcctgagcc agtattagaa      660

gaaactgccc ctgaggatgc tcagaagagt tcttctccag cacctgcaga catagctcag      720

acagtacagg aagacttgag gacattttct tgggcatctg tgaccagtaa gaatcttcca      780

cccagtggag ctgttccagt tactgggata ccacctcatg ttgttaaagt accagcttca      840

cagccccgtc cagagtctaa gcctgaatct cagattccac cacaaagacc tcagcgggat      900

caaagagtgc gagaacaacg aataaatatt cctccccaaa ggggacccag accaatccgt      960

gaggctggtg agcaaggtga cattgaaccc cgaagaatgg tgagacaccc tgacagtcac     1020

caactcttca ttggcaacct gcctcatgaa gtggacaaat cagagcttaa agatttcttt     1080

caaagttatg gaaacgtggt ggagttgcgc attaacagtg gtgggaaatt acccaatttt     1140

ggttttgttg tgtttgatga ttctgagcct gttcagaaag tccttagcaa caggcccatc     1200

atgttcagag gtgaggtccg tctgaatgtc gaagagaaga agactcgagc tgccagggaa     1260

ggcgaccgac gagataatcg ccttcgggga cctggaggcc ctcgaggtgg gctgggtggt     1320

ggaatgagag gccctccccg tggaggcatg gtgcagaaac caggatttgg agtgggaagg     1380

gggcttgcgc cacggcagtg a                                               1401


<210>  1319
<211>  1917
<212>  DNA
<213>  homo sapiens

<400>  1319
atgagcggtg acccagatgt tctggaatac tacaagaacg atcactccaa gaagcctctg       60

cggatcatca acctgaactt ctgtgagcag gtagatgcag gcctgacctt taacaagaag      120

gagctgcagg atagttttgt gtttgacatc aagaccagtg aacgcacctt ttacctggtg      180

gctgagacag aagaggacat gaataagtgg gtccagagca tctgccagat ctgtggcttc      240

aatcaggctg aggagagcac agactccctg agaaatgttt cctcagccgg tcatggcccc      300

cgctcttctc cagctgagct cagcagctct agccagcacc ttctccgaga gcgcaagtcc      360

tcagccccat cacactccag ccagccaact ctgttcacgt ttgaaccccc tgtgtcaaac      420

cacatgcagc ccaccttgtc caccagcgca cctcaggagt atctctactt gcaccagtgc      480

ataagccgaa gagcagaaaa tgcaaggagt gccagcttct ctcagggcac cagagcctct      540

tttctcatga ggagtgacac agctgtacaa aaacttgccc agggcaatgg acactgtgtc      600

aacgggatca gtggtcaagt ccatggcttc tatagccttc ccaagccgag ccggcacaat      660

acagaattca gagacagtac ctacgacctc ccccgcagcc tggcctccca tggccacacc      720

aagggcagcc tcacaggctc cgagacagat aatgaggatg tgtacacctt caagacgccc      780

agcaacaccc tgtgcaggga gttcggggac ctcctggtag acaatatgga tgttccggcc      840

accccactct cagcctacca gatccctagg acattcactc tggacaaaaa ccacaatgcc      900

atgacagtgg ccactcctgg ggactcagcc atagctcccc caccccgccc ccccaagcca      960

agtcaggcag aaacacctcg atggggcagt cctcagcaga gaccgccaat cagtgaaaat     1020

agcagatctg tcgctgccac catccccaga cgcaacaccc tccctgcaat ggacaacagc     1080

cgacttcacc gagcttcttc ctgtgagacc tacgagtacc cacagcgtgg tggagagagt     1140

gcaggccggt ctgctgaatc catgagtgat ggagttggct ctttcctgcc agggaaaatg     1200

attgtgggcc gatcggacag caccaattct gaagacaact atgtgcccat gaatccaggt     1260

tcttccaccc tgttggccat ggaacgagca ggtgataatt cccagagcgt ctacatccca     1320

atgagcccag gggcccatca ctttgactca cttggctacc catcaacaac ccttcctgtg     1380

caccgaggcc ccagcagagg aagtgagatt cagccacccc ctgtcaaccg caacctcaaa     1440

cctgatcgga aagcaaagcc aacaccactt gacctgagga acaacaccgt catcgatgaa     1500

ctccccttca agtcacctat caccaagtct tggtctaggg ccaaccacac cttcaactcc     1560

agctcctccc agtactgccg ccccatctcc acccagagca tcaccagcac agactcagga     1620

gacagcgaag agaactatgt ccctatgcaa aacccagtgt ctgcatctcc cgttcccagt     1680

ggcacgaaca gtcctgcccc taagaagagc accggcagcg ttgattatct ggccctggac     1740

ttccagccga gctccccaag cccccaccgc aagccatcta cttcatccgt cacctctgat     1800

gagaaggtgg actacgttca ggtggacaag gagaagaccc aggccctgca gaacaccatg     1860

caggagtgga cagacgtgcg gcagtcctca gagccttcca agggtgccaa gctgtga        1917


<210>  1320
<211>  903
<212>  DNA
<213>  homo sapiens

<400>  1320
atggagaaga ctcaagaaac agtccaaaga attcttctag aaccctataa atacttactt       60

cagttaccag gtaaacaagt gagaaccaaa ctttcacagg catttaatca ttggctgaaa      120

gttccagagg acaagctaca gattattatt gaagtgacag aaatgttgca taatgccagt      180

ttactcatcg atgatattga agacaactca aaactccgac gtggctttcc agtggcccac      240

agcatctatg gaatcccatc tgtcatcaat tctgccaatt acgtgtattt ccttggcttg      300

gagaaagtct taacccttga tcacccagat gcagtgaagc tttttacccg ccagcttttg      360

gaactccatc agggacaagg cctagatatt tactggaggg ataattacac ttgtcccact      420

gaagaagaat ataaagctat ggtgctgcag aaaacaggtg gactgtttgg attagcagta      480

ggtctcatgc agttgttctc tgattacaaa gaagatttaa aaccgctact taatacactt      540

gggctctttt tccaaattag ggatgattat gctaatctac actccaaaga atatagtgaa      600

aacaaaagtt tttgtgaaga tctgacagag ggaaagttct catttcctac tattcatgct      660

atttggtcaa ggcctgaaag cacccaggtg cagaatatct tgcgccagag aacagaaaac      720

atagatataa aaaaatactg tgtacattat cttgaggatg taggttcttt tgaatacact      780

cgtaataccc ttaaagagct tgaagctaaa gcctataaac agattgatgc acgtggtggg      840

aaccctgagc tagtagcctt agtaaaacac ttaagtaaga tgttcaaaga agaaaatgaa      900

taa                                                                    903


<210>  1321
<211>  858
<212>  DNA
<213>  homo sapiens

<400>  1321
atgaccactt taactcaccg ggcccgtcgc actgaaataa gcaagaactc tgaaaagaag       60

atggaaagtg aggaagacag taattgggag aaaagtccag acaatgaaga ttctggagac      120

tctaaggata tccgccttac tcttatggaa gaagtattgc ttctgggact aaaagataaa      180

gaggggtaca catctttctg gaatgactgc atatcatcag gcctgcgagg gggcatcctg      240

atagagctgg ccatgcgggg tcgaatctat ctggaacccc cgaccatgcg taagaagcga      300

ctactagaca gaaaggtact gctaaagtca gacagcccaa caggtgatgt tttactggat      360

gaaactctga aacacatcaa agcaactgaa cccacagaaa ctgtccaaac atggatagag      420

ctactcactg gtgagacctg gaaccccttc aaattacagt accagctgag aaatgtacga      480

gagcgcatcg caaagaacct agtagagaaa ggtattctaa ccactgagaa gcagaatttc      540

ctgctatttg acatgactac tcatccagtg accaatacaa cagagaaaca gcgactagtg      600

aaaaaacttc aagatagtgt actagagcgg tgggtaaatg accctcagcg tatggacaag      660

cgaacactag cactcctggt gctagcccac tcctctgatg tgctagagaa tgtcttctcc      720

tctctgacag atgacaagta tgatgtggca atgaatcgag ccaaggactt agtagaactg      780

gaccctgaag tggaagggac aaagcctagt gccacagaaa tgatctgggc tgtgctggca      840

gccttcaata aatcttaa                                                    858


<210>  1322
<211>  1974
<212>  DNA
<213>  homo sapiens

<400>  1322
atgcccagat acacggtgca cgtacgtggg gaatggctgg cagtgccctg ccaggacgcg       60

cagctcactg tgggctggct gggccgggag gccgtgaggc gctatatcaa gaataagccc      120

gacaatggtg gcttcacctc cgtggatgac gcgcacttcc ttgtgcgccg gtgcaagggc      180

ctgggcctgc tggacaacga ggaccggctc gaggtggccc tagagaacaa cgagttcgtg      240

gaagtggtta tagagggtga tgccatgtct cctgacttca ttccatctca accagaagga      300

gtttatctat acagcaagta ccgggagcct gaaaagtaca tcgagttaga tggagaccgt      360

ctgaccacgg aggatctggt caacttggga aagggacgct acaaaataaa gctcacccca      420

acagctgaga agagggtgca gaaatccagg gaggtcatag atagcatcat aaaagagaaa      480

acagttgttt acggtattac tacaggtttt gggaaatttg ccagaactgt aattcctatc      540

aataagctac aggagcttca ggtcaactta gtacgctcac attcttcagg tgttgggaaa      600

ccactaagtc ctgagaggtg tcggatgctc ttggctttaa ggatcaatgt cttagccaaa      660

ggatacagtg gcatttccct ggagaccctc aaacaagtca tagaaatgtt taatgcctcc      720

tgcctgccct atgtcccaga gaaaggaacc gttggtgcca gtggagacct tgccccactc      780

tctcatcttg ctcttgggct agttggagaa gggaagatgt ggtctccgaa gagtggctgg      840

gctgatgcta aatacgtgct agaagcccat ggattgaaac cagttatttt aaaaccaaaa      900

gagggcctgg cactcatcaa tgggacgcag atgatcacat ccctgggctg tgaagctgta      960

gagcgagcca gtgctattgc acggcaggct gacattgtgg cagccctgac ccttgaggtg     1020

ctgaagggca ccaccaaagc ctttgacact gacattcatg ctcttcgacc tcaccgtggg     1080

caaattgaag ttgcttttcg gtttcggtca ctcttggact cagatcacca cccatcagaa     1140

atagcagaga gtcacaggtt ctgtgatcgc gtccaggatg catacacctt gcgctgctgt     1200

ccacaggtcc atggtgtggt gaatgataca atagcatttg tgaagaacat cattaccaca     1260

gaactgaaca gcgcaacaga taatcctatg gtctttgcca ataggggaga gacagtttct     1320

ggaggaaact tccatggtga atacccagcc aaagccctag actacttggc cattggcatc     1380

catgaacttg ctgcaatcag tgagagaaga atcgagcggc tctgcaatcc ctccctcagt     1440

gagctgcctg ccttcctggt ggctgaaggt ggtctgaact ctgggttcat gatagctcac     1500

tgcacggcag cagcccttgt ttctgagaac aaggctctgt gccatccctc gtctgttgac     1560

tccctctcca ccagcgcagc cacggaggac cacgtctcca tgggaggatg ggcagcaagg     1620

aaagccctca gggtcatcga gcatgtggag caagtgctgg ccatcgagct ccttgcagcc     1680

tgccagggca tagagtttct acgtcccctg aaaacaacca ctccgctgga gaaggtctat     1740

gacctggtgc gctctgttgt aaggccctgg ataaaagatc gcttcatggc cccggacatc     1800

gaggcagccc acaggctgct cctggagcag aaggtttggg aagtagctgc tccatacatt     1860

gaaaaataca gaatggagca tattccagaa tcaagacctc tttctccaac agccttttca     1920

ctgcaatttc tgcacaagaa atccaccaaa atcccggagt ctgaggacct ttaa           1974


<210>  1323
<211>  6435
<212>  DNA
<213>  homo sapiens

<400>  1323
atgacgtcct tagcccagca gctgcaacga ctcgccctcc ctcaaagtga tgccagcctc       60

ttatctagag atgaagttgc ttctttgtta tttgacccta aggaagcggc cacaatcgac      120

agggacaccg ccttcgccat tggatgtact ggcctggaag agttgcttgg aattgatcct      180

tcctttgagc agtttgaagc accgttgttc agtcagctag caaaaacctt ggagcgaagt      240

gttcagacca aagcagtaaa caaacagttg gatgaaaaca tttcattatt ccttattcac      300

ttgtcgcctt acttcctgct taagccagca cagaagtgtc tggagtggtt gattcacagg      360

ttccatatac atctctataa tcaagatagc ctcattgctt gtgttctgcc ataccacgag      420

acaagaatat ttgtgcgagt catacagctt ctaaaaatta ataattcaaa gcacagatgg      480

ttctggttgt tgccagttaa gcaatctgga gtgccgttag ctaaaggaac tttgattacc      540

cactgctaca aagatcttgg attcatggat ttcatttgca gtttggtgac aaaatctgtg      600

aaggtttttg ctgagtaccc gggcagctca gctcagttga gggtgctctt ggctttctat      660

gcttctacca tagtgtcggc gctggtagct gcagaggacg tatcagacaa tatcatcgcc      720

aaactatttc cctatatcca aaagggattg aaatcatctt taccagatta cagagctgca      780

acatacatga taatatgtca gatttctgtg aaagtgacca tggaaaatac ctttgtgaat      840

tcattggcat cacagatcat caaaacattg accaagattc cctctttgat caaggatggg      900

ttaagttgct tgatagtgct cctgcagaga cagaagccag agagccttgg gaaaaagcca      960

ttccctcact tatgtaatgt tcctgatctt attacaatac ttcatgggat ttctgaaact     1020

tacgatgtca gtcctcttct gcattacatg cttccccatc tggtcgtctc catcattcat     1080

catgttacag gagaagaaac tgaaggaatg gatggtcaaa tctacaagag acacttagaa     1140

gctatactta caaaaatatc actgaagaac aacttagacc atttgttggc tagccttcta     1200

tttgaagagt atatttcata tagttcacag gaagaaatgg attctaataa agtgtctttg     1260

cttaatgaac aatttcttcc actcattagg cttttagaaa gcaaataccc cagaacatta     1320

gatgttgtat tagaggaaca cttaaaggaa attgcagatc tgaaaaaaca agagcttttc     1380

catcagtttg tttctctttc tacaagtgga ggaaagtatc agtttttagc agattctgat     1440

acttctttga tgctcagcct gaatcatcca cttgctcctg tgagaattct ggccatgaat     1500

catttgaaaa agatcatgaa aacatcaaag gagggtgttg atgaatcttt cataaaagaa     1560

gctgttttag cccgattagg tgatgataat atagatgttg ttttgtcggc tataagtgct     1620

tttgagattt tcaaagaaca cttcagttca gaagtgacga tttcaaatct tctgaatctc     1680

tttcaaagag cagaactttc aaagaatgga gaatggtacg aggtacttaa gatagccgct     1740

gacatattaa ttaaagaaga gatactgagt gaaaatgatc agttgtcaaa tcaggtggtt     1800

gtatgtttgc tgccatttat ggttatcaat aatgatgata cggaatctgc tgagatgaaa     1860

attgctatat atttatcaaa atcaggaatc tgctccctgc accctctatt aagaggctgg     1920

gaagaagctc ttgaaaatgt aattaaaagc acaaagccag gaaaactaat cggtgtagca     1980

aatcagaaga tgattgagtt gttggctgat aatataaatt taggagatcc ttcttcaatg     2040

ttaaagatgg tggaggattt aataagcgtg ggtgaggagg agtcctttaa cctgaagcag     2100

aaagtaacgt ttcatgtgat cctgtctgtg ctcgtctctt gttgttcatc tttaaaagaa     2160

acccactttc catttgcgat aagagtcttc agtttgttgc agaaaaaaat aaagaagctt     2220

gaaagtgtca ttactgcagt ggaaatcccc tcagaatggc acattgaact gatgttagac     2280

agagggatcc cagtggagct gtgggcacat tatgtagaag agctcaacag cactcagagg     2340

gtggccgtgg aggactcggt ttttcttgta ttttccttga aaaaatttat ttatgcactg     2400

aaagctccta aatcttttcc taaaggtgat atatggtgga atcctgaaca actgaaagaa     2460

gacagcaggg actatctgca cttgctcatt gggctgtttg agatgatgct caatggtgcc     2520

gatgctgttc atttcagagt tctgatgaaa cttttcataa aggtgcatct agaagatgtt     2580

tttcagttat tcaagttctg ttctgtttta tggacctatg gttctagcct ttcaaatcca     2640

ctaaactgca gtgtgaaaac agtgctgcag actcaagctc tttatgtggg ctgtgcaatg     2700

ctttcttctc agaagacaca gtgtaaacac caactggcat ccatatcttc tccagtggtg     2760

acatctttac tcattaacct gggaagcccc gtaaaagaag ttcgtagggc tgccattcag     2820

tgtctccagg ccctcagtgg agtggcatcc ccgttttatc tgataataga tcatttgatt     2880

tctaaagcag aggagatcac ttcagatgct gcctatgtta ttcaggattt ggctacttta     2940

tttgaggaac tacagagaga aaagaaactg aaatctcatc agaagttgtc tgaaactttg     3000

aaaaacttac ttagttgtgt gtatagttgc ccatcttata tagcaaaaga tttgatgaaa     3060

gtacttcagg gagtcaacgg tgagatggtg ctttctcagc tattgcctat ggctgaacaa     3120

ctgctagaaa agatccagaa ggagcccaca gctgtgctga aagatgaggc catggttctg     3180

catctcactc tgggaaagta taatgaattt tcagtttccc ttttaaatga ggatccgaag     3240

agtctagata tatttataaa agctgtgcac acaacaaagg aactttacgc gggaatgcca     3300

accattcaga tcacagccct tgaaaagatt acaaaaccat tttttgcagc catatcagat     3360

gaaaaagttc agcagaagct tttaagaatg ttgtttgatt tattggtgaa ctgtaaaaac     3420

tcacattgtg ctcagactgt cagcagtgtt tttaaaggga tttccgttaa tgctgaacaa     3480

gtccgaatag aactggagcc accagataaa gctaaaccct tgggcacagt tcagcaaaaa     3540

agaaggcaaa aaatgcagca gaaaaaatca caagatctag aatctgttca ggaagttgga     3600

ggttcttact ggcaaagagt aactctcatc ctggaattac tgcagcacaa aaagaagctc     3660

agaagtcctc agatattggt gccaactctt tttaacttgc tatcaagatg tttagaaccc     3720

ttgccacaag agcagggaaa tatggaatac accaaacaat taattcttag ttgtctgctc     3780

aacatctgcc aaaaactatc tccagatggt ggcaaaatac ccaaagatat tttagatgag     3840

gagaagttca acgtggagtt gatagttcag tgcatccgcc tttcggagat gccgcagacc     3900

catcaccatg cccttttact tttgggcact gttgctggaa tatttccgga taaagtttta     3960

cacaatatca tgtctatttt tacatttatg ggagccaatg tcatgcgcct agatgatact     4020

tacagttttc aagttattaa caagacagtg aaaatggtta ttcccgcact tattcagtct     4080

gatagtggag attctataga agtttcaaga aacgttgaag agattgtggt aaaaatcatt     4140

agtgtatttg tggatgcgct gccacacgtc ccggagcaca ggcgcctgcc catccttgtt     4200

caacttgttg atacactggg tgcagagaaa ttcctctgga ttctcctcat cttgcttttt     4260

gaacagtatg tcacaaaaac agtgctggcg gctgcctatg gcgaaaagga tgctatttta     4320

gaagcagaca ctgaattttg gttttcagtc tgttgtgagt ttagtgtcca gcatcagata     4380

caaagcttga tgaatatcct ccagtactta ctaaagctgc cagaggaaaa agaagaaacc     4440

attcccaaag cagtgtcatt taataagagt gaatcacaag aagaaatgct acaggttttt     4500

aatgtagaga ctcacactag caagcaactg cggcatttta aatttttgtc agtgtccttc     4560

atgtctcagc tcctgtcttc caataatttt ctgaaaaagg tagttgagag tggtggtcct     4620

gagattttaa aaggccttga agagaggttg ctggagaccg ttctcggcta tatcagtgca     4680

gttgcacagt ccatggaaag gaacgcagac aaactcaccg tgaagttctg gcgcgcgctc     4740

cttagtaaag cttacgacct gttagataag gtcaatgcct tgctgcccac agagacattc     4800

attcctgtga tcagagggct ggtgggcaat cccctgccat ctgttcgccg caaagcgctg     4860

gaccttttga ataacaagct gcagcaaaat atatcctgga agaagacaat agttacccgt     4920

ttcctaaaac tggttccaga ccttttggcc attgtgcagc gtaagaaaaa ggaaggggaa     4980

gaagaacaag caatcaacag acagacagcg ttgtatacct taaagctttt atgcaagaat     5040

tttggtgcag aaaatccaga tccttttgtc ccagtgctga acactgctgt gaaactgatt     5100

gctccagaga gaaaggagga gaagaatgtc ctgggaagcg cgctgctgtg catagcagag     5160

gtgacctcca ccctggaggc gctggccatc ccccagcttc ccagcctgat gccatcgttg     5220

ctgacaacaa tgaagaacac cagcgagctg gtctccagcg aggtctacct gctcagtgcc     5280

ttggctgctc tgcagaaggt tgtggagact ctcccgcact tcatcagccc ctatctggaa     5340

ggcattctct cccaggtgat tcatctggag aaaatcacta gtgaaatggg ttctgcgtca     5400

caggctaata tccgtctcac atctcttaaa aagacactgg ctaccacact tgcaccccga     5460

gtcctgttgc ccgccatcaa aaaaacttac aagcagattg agaagaactg gaagaatcac     5520

atgggtccgt ttatgagcat cttgcaagag catattgggg tgatgaagaa ggaagagctc     5580

acctcccatc agtctcagct aaccgccttt ttcctggaag ccctggactt ccgagcccag     5640

cactctgaga acgatctgga ggaagttgga aaaacggaaa attgtatcat tgactgtcta     5700

gtagccatgg ttgtcaaact ttccgaggtc acattcaggc ccctgttctt caagctgttt     5760

gattgggcta aaacagaaga tgccccaaag gacaggttgt tgacatttta caacttggca     5820

gattgcattg ctgaaaagct gaaagggctt tttactctgt ttgccggcca cttagtgaag     5880

ccttttgctg acaccttgaa ccaggtgaac atctccaaaa cagatgaagc attttttgac     5940

tctgaaaatg accctgaaaa gtgctgcttg ctgttgcagt ttattttgaa ctgtttatac     6000

aaaatcttcc tttttgatac ccagcatttt ataagtaaag agagagcaga agccttgatg     6060

atgcctctgg tggatcagct ggaaaacagg cttgggggag aagagaaatt ccaggaacgg     6120

gtgacaaagc acctgatacc atgcatcgca cagttttcgg tggccatggc ggatgactct     6180

ctttggaaac cactgaacta ccagattctg ctaaagacga gagactcctc gcctaaggtt     6240

cgatttgctg ctttgattac tgtgttagca ctggctgaaa aactaaagga gaattatatt     6300

gtcttgctac cagaatccat tcctttctta gcagagttga tggaagatga atgtgaagaa     6360

gtagaacatc agtgccaaaa gactattcag caactggaaa ctgtcctggg agagccactc     6420

cagagctatt tctaa                                                      6435


<210>  1324
<211>  618
<212>  DNA
<213>  homo sapiens

<400>  1324
atggccgagc cgctccagcc agaccccggg gcggccgagg acgcggcggc ccaagctgtg       60

gagacgccgg gctggaaggc cccggaggac gccggccccc agcccggaag ttatgagatc      120

cgacactatg gaccagccaa gtgggtcagc acgtccgtgg agtctatgga ctgggattca      180

gccatccaga cgggctttac gaaactgaac agctacattc aaggcaaaaa cgagaaagag      240

atgaaaataa agatgacagc tccagtgaca agctacgtgg agcctggttc aggtcctttt      300

agtgagtcta ccattaccat ttccctgtat attccctctg aacagcaatt tgatccaccc      360

aggcctttag agtcagatgt cttcattgaa gatagagccg aaatgactgt gtttgtacgg      420

tctttcgatg gattttctag tgcccaaaag aatcaagaac aacttttgac attagcaagc      480

attttaaggg aagatggaaa agttttcgat gagaaggttt actacactgc aggctacaac      540

agtcctgtca aattgcttaa tagaaataat gaagtgtggt tgattcaaaa aaatgaaccc      600

accaaagaaa acgaatga                                                    618


<210>  1325
<211>  1161
<212>  DNA
<213>  homo sapiens

<400>  1325
atggggcagc gcgagatgtg gaggctcatg tcgaggttta atgcattcaa aaggactaat       60

accatactgc accatttgag aatgtccaag cacacagatg cagcagaaga ggtgctattg      120

gaaaaaaaag gttgcacggg agtcataaca ctaaacagac caaagttcct caatgcactg      180

actcttaata tgattcggca gatttatcca cagctaaaga agtgggaaca agatcctgaa      240

actttcctga tcattataaa gggagcagga ggaaaggctt tctgtgccgg gggtgatatc      300

agagtgatct cggaagctga aaaggcaaaa cagaagatag ctccagtttt cttcagagaa      360

gaatatatgc tgaataatgc tgttggttct tgccagaaac cttatgttgc acttattcat      420

ggaattacaa tgggtggggg agttggtctc tcagtccatg ggcaatttcg agtggctaca      480

gaaaagtgtc tttttgctat gccagaaact gcaataggac tgttccctga tgtgggtgga      540

ggttatttct tgccacgact ccaaggaaaa cttggttact tccttgcatt aacaggattc      600

agactaaaag gaagagatgt gtacagagca ggaattgcta cacactttgt agattctgaa      660

aagttggcca tgttagagga agatttgtta gccttgaaat ctccttcaaa agaaaatatt      720

gcatctgtct tagaaaatta ccatacagag tctaagattg atcgagacaa gtcttttata      780

cttgaggaac acatggacaa aataaacagt tgtttttcag ccaatactgt ggaagaaatt      840

attgaaaact tacagcaaga tggttcatct tttgccctag agcaattgaa ggtaattaat      900

aaaatgtctc caacatctct aaagatcaca ctaaggcaac tcatggaggg gtcttcaaag      960

accttgcaag aagtactaac tatggagtat cggctaagtc aagcttgtat gagaggtcat     1020

gactttcatg aaggcgttag agctgtttta attgataaag accagagtcc aaaatggaaa     1080

ccagctgatc taaaagaagt tactgaggaa gatttgaata atcactttaa gtctttggga     1140

agcagtgatt tgaaattttg a                                               1161


<210>  1326
<211>  3030
<212>  DNA
<213>  homo sapiens

<400>  1326
atgtcctgga tgttcaagag ggatccagtt tggaagtact tgcagactgt ccagtatgga       60

gttcatggaa attttccacg cctctcatat ccaactttct ttccacgttt tgaattccaa      120

gatgttatcc ctccagatga ctttctaact agtgatgaag aagtagattc cgttttattt      180

ggaagtttga gaggtcatgt ggttggacta cgctattaca cgggagtagt taataataat      240

gaaatggttg cattacaacg agatcctaat aacccttatg ataagaatgc aattaaagta      300

aacaatgtga atggaaatca agttggccat ttaaagaaag agcttgcagg tgctttggcc      360

tatatcatgg acaacaaatt ggcacaaatt gaaggggtag ttccttttgg tgcaaacaat      420

gcttttacca tgcctctgca tatgactttt tggggaaaag aagaaaatag aaaagcggtt      480

tcagatcagt tgaagaaaca tggatttaaa ttgggtcctg caccaaaaac tttaggattc      540

aatttggaaa gtggttgggg ctctggaaga gctggaccaa gctatagtat gccagtgcat      600

gctgcagtac agatgacaac tgaacagctt aaaacagaat ttgacaaatt gtttgaagat      660

ttaaaagaag atgataaaac ccatgaaatg gaaccagctg aggctattga aacaccactg      720

cttccacatc aaaaacaagc tctagcttgg atggtgtcac gggaaaatag caaagaactt      780

ccaccattct gggaacagcg aaatgactta tactataaca caataacaaa tttttctgag      840

aaggaccgac cagaaaatgt ccatggagga attttagctg atgatatggg tttgggtaaa      900

actcttacgg ccattgcagt aatccttacc aacttccatg atggcagacc tcttcctatt      960

gaaagagtta aaaagaatct actgaagaag gaatataatg ttaacgatga ctctatgaaa     1020

cttggaggaa acaataccag tgaaaaggca gatggactaa gcaaagacgc atctagatgt     1080

agtgaacaac ccagtatttc agatatcaag gagaagagta agtttcgcat gtcagaattg     1140

tctagctccc gccccaaaag aagaaaaact gctgtccagt acatagaaag cagtgattca     1200

gaggaaattg aaacaagtga attgccgcag aaaatgaaag gcaaactgaa aaatgtacag     1260

tctgaaacta aaggcagggc gaaagcagga tcttctaagg ttatagaaga tgtggcattt     1320

gcatgtgcat taacttcatc tgttcctaca acaaaaaaga aaatgttgaa aaagggagct     1380

tgtgcagtgg aggggtcaaa gaaaactgat gttgaggaga gaccaagaac aacactgatc     1440

atctgtccgc tttctgtgtt aagcaactgg attgaccagt ttggacaaca tataaaatca     1500

gatgtacact tgaattttta tgtttattat ggtcctgatc gtattagaga accggcctta     1560

ctttcaaaac aggatattgt tttgactacg tataatattt taactcatga ctatggaact     1620

aaaggagata gtccattaca tagcataagg tggctaagag tgatcctgga tgaaggacat     1680

gccatacgaa atccaaatgc tcagcagaca aaagctgtac ttgacttaga atcagaaaga     1740

agatgggttt tgacaggtac tccaatccag aattctttaa aggacttgtg gtctcttctt     1800

tcctttttaa aacttaaacc atttattgat agagaatggt ggcatagaac aatacagcgt     1860

cctgtcacaa tgggagatga aggaggactt aggcgtttac agtccctaat taaaaatatt     1920

acacttagaa gaacaaagac aagcaaaatt aaaggaaaac ctgttttgga gttaccagaa     1980

cgtaaagtat ttattcagca cattacactt tcagatgaag agagaaagat ttatcagtct     2040

gtgaaaaatg aaggcagagc cactattgga aggtatttta atgaagggac tgtcctggca     2100

cattatgcag atgtcctggg tcttttgctt agactgcggc aaatttgttg ccatacttac     2160

cttcttacaa atgcagtgtc ttccaatggc ccctcaggaa atgatacacc tgaagaactg     2220

agaaagaagt taataaggaa gatgaagtta attctgagct caggttcaga tgaggaatgt     2280

gcaatttgcc tggattcttt aacagttcct gtgataacac attgtgcaca tgtattttgt     2340

aaaccctgta tttgccaagt cattcagaat gagcagccac atgctaaatg ccctttatgc     2400

agaaatgata tacatgaaga taatttatta gaatgtcctc cagaagaatt agcacgtgac     2460

agtgagaaaa agtctgatat ggaatggaca tccagttcaa agattaatgc gctaatgcac     2520

gcattgactg acttaagaaa gaagaatccc aacataaaaa gtttggttgt ttctcagttt     2580

acaacattcc tgtctttaat agaaatacca cttaaagcct ctggatttgt gtttactcgt     2640

ttggatggtt ccatggccca aaagaaaaga gttgaatcaa ttcagtgttt tcaaaacact     2700

gaagcaggat ctccaactat aatgcttctg tccttaaaag caggtggagt tggtttgaat     2760

ctgtctgcag cttctcgagt gtttttaatg gatccagcct ggaatcctgc tgctgaagat     2820

cagtgctttg acagatgcca tagacttggt cagaagcaag aagttatcat cacaaaattc     2880

attgtaaagg actctgttga agaaaatatg ctgaaaatac aaaacaaaaa gagagaactt     2940

gcagcaggag cctttggaac taaaaaacca aatgctgacg aaatgaaaca agccaaaatt     3000

aatgaaatca gaacattaat tgacttataa                                      3030


<210>  1327
<211>  1173
<212>  DNA
<213>  homo sapiens

<400>  1327
atgccagata ctaatagcac aatcaattta tcactaagca ctcgtgttac tttagcattt       60

tttatgtcct tagtagcttt tgctataatg ctaggaaatg ctttggtcat tttagctttt      120

gtggtggaca aaaaccttag acatcgaagt agttattttt ttcttaactt ggccatctct      180

gacttctttg tgggtgtgat ctccattcct ttgtacatcc ctcacacgct gttcgaatgg      240

gattttggaa aggaaatctg tgtattttgg ctcactactg actatctgtt atgtacagca      300

tctgtatata acattgtcct catcagctat gatcgatacc tgtcagtctc aaatgctgtg      360

tcttatagaa ctcaacatac tggggtcttg aagattgtta ctctgatggt ggccgtttgg      420

gtgctggcct tcttagtgaa tgggccaatg attctagttt cagagtcttg gaaggatgaa      480

ggtagtgaat gtgaacctgg atttttttcg gaatggtaca tccttgccat cacatcattc      540

ttggaattcg tgatcccagt catcttagtc gcttatttca acatgaatat ttattggagc      600

ctgtggaagc gtgatcatct cagtaggtgc caaagccatc ctggactgac tgctgtctct      660

tccaacatct gtggacactc attcagaggt agactatctt caaggagatc tctttctgca      720

tcgacagaag ttcctgcatc ctttcattca gagagacaga ggagaaagag tagtctcatg      780

ttttcctcaa gaaccaagat gaatagcaat acaattgctt ccaaaatggg ttccttctcc      840

caatcagatt ctgtagctct tcaccaaagg gaacatgttg aactgcttag agccaggaga      900

ttagccaagt cactggccat tctcttaggg gtttttgctg tttgctgggc tccatattct      960

ctgttcacaa ttgtcctttc attttattcc tcagcaacag gtcctaaatc agtttggtat     1020

agaattgcat tttggcttca gtggttcaat tcctttgtca atcctctttt gtatccattg     1080

tgtcacaagc gctttcaaaa ggctttcttg aaaatatttt gtataaaaaa gcaacctcta     1140

ccatcacaac acagtcggtc agtatcttct taa                                  1173


<210>  1328
<211>  3060
<212>  DNA
<213>  homo sapiens

<400>  1328
atgcggtacc ggctagcgtg gcttctgcac cccgcactgc ccagcacctt ccgctcagtc       60

ctcggcgccc gcctgccgcc tccggagcgc ctgtgtggtt tccaaaaaaa gacttacagc      120

aaaatgaata atccagccat caagagaata ggaaatcaca ttaccaagtc tcctgaagac      180

aagcgagaat atcgagggct agagctggcc aatggtatca aagtacttct tatcagtgat      240

cccaccacgg ataagtcatc agcagcactt gatgtgcaca taggttcatt gtcggatcct      300

ccaaatattg ctggcttaag tcatttttgt gaacatatgc tttttttggg aacaaagaaa      360

taccctaaag aaaatgaata cagccagttt ctcagtgagc atgcaggaag ttcaaatgcc      420

tttactagtg gagagcatac caattactat tttgatgttt ctcatgaaca cctagaaggt      480

gccctagaca ggtttgcaca gttttttctg tgccccttgt tcgatgaaag ttgcaaagac      540

agagaggtga atgcagttga ttcagaacat gagaagaatg tgatgaatga tgcctggaga      600

ctctttcaat tggaaaaagc tacagggaat cctaaacacc ccttcagtaa atttgggaca      660

ggtaacaaat atactctgga gactagacca aaccaagaag gcattgatgt aagacaagag      720

ctactgaaat tccattctgc ttactattca tccaacttaa tggctgtttg tgttttaggt      780

cgagaatctt tagatgactt gactaatctg gtggtaaagt tattttctga agtagagaac      840

aaaaatgttc cattgccaga atttcctgaa caccctttcc aagaagaaca tcttaaacaa      900

ctttacaaaa tagtacccat taaagatatt aggaatctct atgtgacatt tcccatacct      960

gaccttcaga aatactacaa atcaaatcct ggtcattatc ttggtcatct cattgggcat     1020

gaaggtcctg gaagtctgtt atcagaactt aagtcaaagg gctgggttaa tactcttgtt     1080

ggtgggcaga aggaaggagc ccgaggtttt atgtttttta tcattaatgt ggacttgacc     1140

gaggaaggat tattacatgt tgaagatata attttgcaca tgtttcaata cattcagaag     1200

ttacgtgcag aaggacctca agaatgggtt ttccaagagt gcaaggactt gaatgctgtt     1260

gcttttaggt ttaaagacaa agagaggcca cggggctata catctaagat tgcaggaata     1320

ttgcattatt atcccctaga agaggtgctc acagcggaat atttactgga agaatttaga     1380

cctgacttaa tagagatggt tctcgataaa ctcagaccag aaaatgtccg ggttgccata     1440

gtttctaaat cttttgaagg aaaaactgat cgcacagaag agtggtatgg aacccagtac     1500

aaacaagaag ctataccgga tgaagtcatc aagaaatggc aaaatgctga cctgaatggg     1560

aaatttaaac ttcctacaaa gaatgaattt attcctacga attttgagat tttaccgtta     1620

gaaaaagagg cgacaccata ccctgctctt attaaggata cagctatgag caaactttgg     1680

ttcaaacaag atgataagtt ttttttgccg aaggcttgtc tcaactttga atttttcagc     1740

ccatttgctt atgtggaccc cttgcactgt aacatggcct atttgtacct tgagctcctc     1800

aaagactcac tcaacgagta tgcatatgca gcagagctag caggcttgag ctatgatctc     1860

caaaatacca tctatgggat gtatctttca gtgaaaggtt acaatgacaa gcagccaatt     1920

ttactaaaga agattattga gaaaatggct acctttgaga ttgatgaaaa aagatttgaa     1980

attatcaaag aagcatatat gcgatctctt aacaatttcc gggctgaaca gcctcaccag     2040

catgccatgt actacctccg cttgctgatg actgaagtgg cctggactaa agatgagtta     2100

aaagaagctc tggatgatgt aacccttcct cgccttaagg ccttcatacc tcagctcctg     2160

tcacggctgc acattgaagc ccttctccat ggaaacataa caaagcaggc tgcattagga     2220

attatgcaga tggttgaaga caccctcatt gaacatgctc ataccaaacc tctccttcca     2280

agtcagctgg ttcggtatag agaagttcag ctccctgaca gaggatggtt tgtttatcag     2340

cagagaaatg aagttcacaa taactgtggc atcgagatat actaccaaac agacatgcaa     2400

agcacctcag agaatatgtt tctggagctc ttctgtcaga ttatctcgga accttgcttc     2460

aacaccctgc gcaccaagga gcagttgggc tatatcgtct tcagcgggcc acgtcgagct     2520

aatggcatac agggcttgag attcatcatc cagtcagaaa agccacctca ctacctagaa     2580

agcagagtgg aagctttctt aattaccatg gaaaagtcca tagaggacat gacagaagag     2640

gccttccaaa aacacattca ggcattagca attcgtcgac tagacaaacc aaagaagcta     2700

tctgctgagt gtgctaaata ctggggagaa atcatctccc agcaatataa ttttgacaga     2760

gataacactg aggttgcata tttaaagaca cttaccaagg aagatatcat caaattctac     2820

aaggaaatgt tggcagtaga tgctccaagg agacataagg tatccgtcca tgttcttgcc     2880

agggaaatgg attcttgtcc tgttgttgga gagttcccat gtcaaaatga cataaatttg     2940

tcacaagcac cagccttgcc acaacctgaa gtgattcaga acatgaccga attcaagcgt     3000

ggtctgccac tgtttcccct tgtgaaacca catattaact tcatggctgc aaaactctga     3060


<210>  1329
<211>  7476
<212>  DNA
<213>  homo sapiens

<400>  1329
atgggggccg ccgccggccg gagcccccac ctggggcccg cgcccgcccg ccgcccgcag       60

cgctctctgc tcctgctgca gctgctgctg ctcgtcgctg ccccggggtc cacgcaggcc      120

caggccgccc cgttccccga gctgtgcagt tatacatggg aagctgttga taccaaaaat      180

aatgtacttt ataaaatcaa catctgtgga agtgtggata ttgtccagtg cgggccatca      240

agtgctgttt gtatgcacga cttgaagaca cgcacttatc attcagtggg tgactctgtt      300

ttgagaagtg caaccagatc tctcctggaa ttcaacacaa cagtgagctg tgaccagcaa      360

ggcacaaatc acagagtcca gagcagcatt gccttcctgt gtgggaaaac cctgggaact      420

cctgaatttg taactgcaac agaatgtgtg cactactttg agtggaggac cactgcagcc      480

tgcaagaaag acatatttaa agcaaataag gaggtgccat gctatgtgtt tgatgaagag      540

ttgaggaagc atgatctcaa tcctctgatc aagcttagtg gtgcctactt ggtggatgac      600

tccgatccgg acacttctct attcatcaat gtttgtagag acatagacac actacgagac      660

ccaggttcac agctgcgggc ctgtcccccc ggcactgccg cctgcctggt aagaggacac      720

caggcgtttg atgttggcca gccccgggac ggactgaagc tggtgcgcaa ggacaggctt      780

gtcctgagtt acgtgaggga agaggcagga aagctagact tttgtgatgg tcacagccct      840

gcggtgacta ttacatttgt ttgcccgtcg gagcggagag agggcaccat tcccaaactc      900

acagctaaat ccaactgccg ctatgaaatt gagtggatta ctgagtatgc ctgccacaga      960

gattacctgg aaagtaaaac ttgttctctg agcggcgagc agcaggatgt ctccatagac     1020

ctcacaccac ttgcccagag cggaggttca tcctatattt cagatggaaa agaatatttg     1080

ttttatttga atgtctgtgg agaaactgaa atacagttct gtaataaaaa acaagctgca     1140

gtttgccaag tgaaaaagag cgatacctct caagtcaaag cagcaggaag ataccacaat     1200

cagaccctcc gatattcgga tggagacctc accttgatat attttggagg tgatgaatgc     1260

agctcagggt ttcagcggat gagcgtcata aactttgagt gcaataaaac cgcaggtaac     1320

gatgggaaag gaactcctgt attcacaggg gaggttgact gcacctactt cttcacatgg     1380

gacacggaat acgcctgtgt taaggagaag gaagacctcc tctgcggtgc caccgacggg     1440

aagaagcgct atgacctgtc cgcgctggtc cgccatgcag aaccagagca gaattgggaa     1500

gctgtggatg gcagtcagac ggaaacagag aagaagcatt ttttcattaa tatttgtcac     1560

agagtgctgc aggaaggcaa ggcacgaggg tgtcccgagg acgcggcagt gtgtgcagtg     1620

gataaaaatg gaagtaaaaa tctgggaaaa tttatttcct ctcccatgaa agagaaagga     1680

aacattcaac tctcttattc agatggtgat gattgtggtc atggcaagaa aattaaaact     1740

aatatcacac ttgtatgcaa gccaggtgat ctggaaagtg caccagtgtt gagaacttct     1800

ggggaaggcg gttgctttta tgagtttgag tggcacacag ctgcggcctg tgtgctgtct     1860

aagacagaag gggagaactg cacggtcttt gactcccagg cagggttttc ttttgactta     1920

tcacctctca caaagaaaaa tggtgcctat aaagttgaga caaagaagta tgacttttat     1980

ataaatgtgt gtggcccggt gtctgtgagc ccctgtcagc cagactcagg agcctgccag     2040

gtggcaaaaa gtgatgagaa gacttggaac ttgggtctga gtaatgcgaa gctttcatat     2100

tatgatggga tgatccaact gaactacaga ggcggcacac cctataacaa tgaaagacac     2160

acaccgagag ctacgctcat cacctttctc tgtgatcgag acgcgggagt gggcttccct     2220

gaatatcagg aagaggataa ctccacctac aacttccggt ggtacaccag ctatgcctgc     2280

ccggaggagc ccctggaatg cgtagtgacc gacccctcca cgctggagca gtacgacctc     2340

tccagtctgg caaaatctga aggtggcctt ggaggaaact ggtatgccat ggacaactca     2400

ggggaacatg tcacgtggag gaaatactac attaacgtgt gtcggcctct gaatccagtg     2460

ccgggctgca accgatatgc atcggcttgc cagatgaagt atgaaaaaga tcagggctcc     2520

ttcactgaag tggtttccat cagtaacttg ggaatggcaa agaccggccc ggtggttgag     2580

gacagcggca gcctccttct ggaatacgtg aatgggtcgg cctgcaccac cagcgatggc     2640

agacagacca catataccac gaggatccat ctcgtctgct ccaggggcag gctgaacagc     2700

caccccatct tttctctcaa ctgggagtgt gtggtcagtt tcctgtggaa cacagaggct     2760

gcctgtccca ttcagacaac gacggataca gaccaggctt gctctataag ggatcccaac     2820

agtggatttg tgtttaatct taatccgcta aacagttcgc aaggatataa cgtctctggc     2880

attgggaaga tttttatgtt taatgtctgc ggcacaatgc ctgtctgtgg gaccatcctg     2940

ggaaaacctg cttctggctg tgaggcagaa acccaaactg aagagctcaa gaattggaag     3000

ccagcaaggc cagtcggaat tgagaaaagc ctccagctgt ccacagaggg cttcatcact     3060

ctgacctaca aagggcctct ctctgccaaa ggtaccgctg atgcttttat cgtccgcttt     3120

gtttgcaatg atgatgttta ctcagggccc ctcaaattcc tgcatcaaga tatcgactct     3180

gggcaaggga tccgaaacac ttactttgag tttgaaaccg cgttggcctg tgttccttct     3240

ccagtggact gccaagtcac cgacctggct ggaaatgagt acgacctgac tggcctaagc     3300

acagtcagga aaccttggac ggctgttgac acctctgtcg atgggagaaa gaggactttc     3360

tatttgagcg tttgcaatcc tctcccttac attcctggat gccagggcag cgcagtgggg     3420

tcttgcttag tgtcagaagg caatagctgg aatctgggtg tggtgcagat gagtccccaa     3480

gccgcggcga atggatcttt gagcatcatg tatgtcaacg gtgacaagtg tgggaaccag     3540

cgcttctcca ccaggatcac gtttgagtgt gctcagatat cgggctcacc agcatttcag     3600

cttcaggatg gttgtgagta cgtgtttatc tggagaactg tggaagcctg tcccgttgtc     3660

agagtggaag gggacaactg tgaggtgaaa gacccaaggc atggcaactt gtatgacctg     3720

aagcccctgg gcctcaacga caccatcgtg agcgctggcg aatacactta ttacttccgg     3780

gtctgtggga agctttcctc agacgtctgc cccacaagtg acaagtccaa ggtggtctcc     3840

tcatgtcagg aaaagcggga accgcaggga tttcacaaag tggcaggtct cctgactcag     3900

aagctaactt atgaaaatgg cttgttaaaa atgaacttca cgggggggga cacttgccat     3960

aaggtttatc agcgctccac agccatcttc ttctactgtg accgcggcac ccagcggcca     4020

gtatttctaa aggagacttc agattgttcc tacttgtttg agtggcgaac gcagtatgcc     4080

tgcccacctt tcgatctgac tgaatgttca ttcaaagatg gggctggcaa ctccttcgac     4140

ctctcgtccc tgtcaaggta cagtgacaac tgggaagcca tcactgggac gggggacccg     4200

gagcactacc tcatcaatgt ctgcaagtct ctggccccgc aggctggcac tgagccgtgc     4260

cctccagaag cagccgcgtg tctgctgggt ggctccaagc ccgtgaacct cggcagggta     4320

agggacggac ctcagtggag agatggcata attgtcctga aatacgttga tggcgactta     4380

tgtccagatg ggattcggaa aaagtcaacc accatccgat tcacctgcag cgagagccaa     4440

gtgaactcca ggcccatgtt catcagcgcc gtggaggact gtgagtacac ctttgcctgg     4500

cccacagcca cagcctgtcc catgaagagc aacgagcatg atgactgcca ggtcaccaac     4560

ccaagcacag gacacctgtt tgatctgagc tccttaagtg gcagggcggg attcacagct     4620

gcttacagcg agaaggggtt ggtttacatg agcatctgtg gggagaatga aaactgccct     4680

cctggcgtgg gggcctgctt tggacagacc aggattagcg tgggcaaggc caacaagagg     4740

ctgagatacg tggaccaggt cctgcagctg gtgtacaagg atgggtcccc ttgtccctcc     4800

aaatccggcc tgagctataa gagtgtgatc agtttcgtgt gcaggcctga ggccaggcca     4860

accaataggc ccatgctcat ctccctggac aagcagacat gcactctctt cttctcctgg     4920

cacacgccgc tggcctgcga gcaagcgacc gaatgttccg tgaggaatgg aagctctatt     4980

gttgacttgt ctccccttat tcatcgcact ggtggttatg aggcttatga tgagagtgag     5040

gatgatgcct ccgataccaa ccctgatttc tacatcaata tttgtcagcc actaaatccc     5100

atgcacggag tgccctgtcc tgccggagcc gctgtgtgca aagttcctat tgatggtccc     5160

cccatagata tcggccgggt agcaggacca ccaatactca atccaatagc aaatgagatt     5220

tacttgaatt ttgaaagcag tactccttgc ttagcggaca agcatttcaa ctacacctcg     5280

ctcatcgcgt ttcactgtaa gagaggtgtg agcatgggaa cgcctaagct gttaaggacc     5340

agcgagtgcg actttgtgtt cgaatgggag actcctgtcg tctgtcctga tgaagtgagg     5400

atggatggct gtaccctgac agatgagcag ctcctctaca gcttcaactt gtccagcctt     5460

tccacgagca cctttaaggt gactcgcgac tcgcgcacct acagcgttgg ggtgtgcacc     5520

tttgcagtcg ggccagaaca aggaggctgt aaggacggag gagtctgtct gctctcaggc     5580

accaaggggg catcctttgg acggctgcaa tcaatgaaac tggattacag gcaccaggat     5640

gaagcggtcg ttttaagtta cgtgaatggt gatcgttgcc ctccagaaac cgatgacggc     5700

gtcccctgtg tcttcccctt catattcaat gggaagagct acgaggagtg catcatagag     5760

agcagggcga agctgtggtg tagcacaact gcggactacg acagagacca cgagtggggc     5820

ttctgcagac actcaaacag ctaccggaca tccagcatca tatttaagtg tgatgaagat     5880

gaggacattg ggaggccaca agtcttcagt gaagtgcgtg ggtgtgatgt gacatttgag     5940

tggaaaacaa aagttgtctg ccctccaaag aagttggagt gcaaattcgt ccagaaacac     6000

aaaacctacg acctgcggct gctctcctct ctcaccgggt cctggtccct cgtccacaac     6060

ggagtctcgt actatataaa tctgtgccag aaaatatata aagggcccct gggctgctct     6120

gaaagggcca gcatttgcag aaggaccaca actggtgacg tccaggtcct gggactcgtt     6180

cacacgcaga agctgggtgt cataggtgac aaagttgttg tcacgtactc caaaggttat     6240

ccgtgtggtg gaaataagac cgcatcctcc gtgatagaat tgacctgtac aaagacggtg     6300

ggcagacctg cattcaagag gtttgatatc gacagctgca cttactactt cagctgggac     6360

tcccgggctg cctgcgccgt gaagcctcag gaggtgcaga tggtgaatgg gaccatcacc     6420

aaccctataa atggcaagag cttcagcctc ggagatattt attttaagct gttcagagcc     6480

tctggggaca tgaggaccaa tggggacaac tacctgtatg agatccaact ttcctccatc     6540

acaagctcca gaaacccggc gtgctctgga gccaacatat gccaggtgaa gcccaacgat     6600

cagcacttca gtcggaaagt tggaacctct gacaagacca agtactacct tcaagacggc     6660

gatctcgatg tcgtgtttgc ctcttcctct aagtgcggaa aggataagac caagtctgtt     6720

tcttccacca tcttcttcca ctgtgaccct ctggtggagg acgggatccc cgagttcagt     6780

cacgagactg ccgactgcca gtacctcttc tcttggtaca cctcagccgt gtgtcctctg     6840

ggggtgggct ttgacagcga gaatcccggg gacgacgggc agatgcacaa ggggctgtca     6900

gaacggagcc aggcagtcgg cgcggtgctc agcctgctgc tggtggcgct cacctgctgc     6960

ctgctggccc tgttgctcta caagaaggag aggagggaaa cagtgataag taagctgacc     7020

acttgctgta ggagaagttc caacgtgtcc tacaaatact caaaggtgaa taaggaagaa     7080

gagacagatg agaatgaaac agagtggctg atggaagaga tccagctgcc tcctccacgg     7140

cagggaaagg aagggcagga gaacggccat attaccacca agtcagtgaa agccctcagc     7200

tccctgcatg gggatgacca ggacagtgag gatgaggttc tgaccatccc agaggtgaaa     7260

gttcactcgg gcaggggagc tggggcagag agctcccacc cagtgagaaa cgcacagagc     7320

aatgcccttc aggagcgtga ggacgatagg gtggggctgg tcaggggtga gaaggcgagg     7380

aaagggaagt ccagctctgc acagcagaag acagtgagct ccaccaagct ggtgtccttc     7440

catgacgaca gcgacgagga cctcttacac atctga                               7476


<210>  1330
<211>  3999
<212>  DNA
<213>  homo sapiens

<400>  1330
atgcgaaatc tgaaattatt tcggaccctg gagttcaggg atattcaagg tccagggaat       60

cctcagtgct tctctctccg aactgaacag gggacggtgc tcattggttc agaacatggc      120

ctgatagaag tagaccctgt ctcaagagaa gtgaaaaatg aagtttcttt ggtggcagaa      180

ggctttctcc cagaggatgg aagtggccgc attgttggtg ttcaggactt gctggatcag      240

gagtctgtgt gtgtggccac agcctctgga gacgtcatac tctgcagtct cagcacacaa      300

cagctggagt gtgttgggag tgtagccagt ggtatctctg ttatgagttg gagtcctgac      360

caagagctgg tgcttcttgc cacaggtcaa cagaccctga ttatgatgac aaaagatttt      420

gagccaatcc tggagcagca gatccatcag gatgattttg gtgaaagcaa gtttatcact      480

gttggatggg gtaggaagga gacacagttc catggatcag aaggcagaca agcagctttt      540

cagatgcaaa tgcatgagtc tgctttgccc tgggatgacc atagaccaca agttacctgg      600

cggggggatg gacagttttt tgctgtgagt gttgtttgcc cagaaacagg ggctcggaag      660

gtcagagtgt ggaaccgaga gtttgctttg cagtcaacca gtgagcctgt ggcaggactg      720

ggaccagccc tggcttggaa accctcaggc agtttgattg catctacaca agataaaccc      780

aaccagcagg atattgtgtt ttttgagaaa aatggactcc ttcatggaca ctttacactt      840

cccttcctta aagatgaggt taaggtaaat gacttgctct ggaatgcaga ttcctctgtg      900

cttgcagtct ggctggaaga ccttcagaga gaagaaagct ccattccgaa aacctgtgtt      960

cagctctgga ctgttggaaa ctatcactgg tatctcaagc aaagtttatc cttcagcacc     1020

tgtgggaaga gcaagattgt gtctctgatg tgggaccctg tgaccccata ccggctgcat     1080

gttctctgtc agggctggca ttacctcgcc tatgattggc actggacgac tgaccggagc     1140

gtgggagata attcaagtga cttgtccaat gtggctgtca ttgatggaaa cagggtgttg     1200

gtgacagtct tccggcagac tgtggttccg cctcccatgt gcacctacca actgctgttc     1260

ccacaccctg tgaatcaagt cacattctta gcacaccctc aaaagagtaa tgaccttgct     1320

gttctagatg ccagtaacca gatttctgtt tataaatgtg gtgattgtcc aagtgctgac     1380

cctacagtga aactgggagc tgtgggtgga agtggattta aagtttgcct tagaactcct     1440

catttggaaa agagatacaa aatccagttt gagaataatg aagatcaaga tgtaaacccg     1500

ctgaaactag gccttctcac ttggattgaa gaagacgtct tcctggctgt aagccacagt     1560

gagttcagcc cccggtctgt cattcaccat ttgactgcag cttcttctga gatggatgaa     1620

gagcatggac agctcaatgt cagttcatct gcagcggtgg atggggtcat aatcagtcta     1680

tgttgcaatt ccaagaccaa gtcagtagta ttacagctgg ctgatggcca gatatttaag     1740

tacctttggg agtcaccttc tctggctatt aaaccatgga agaactctgg tggatttcct     1800

gttcggtttc cttatccatg cacccagacc gaattggcca tgattggaga agaggaatgt     1860

gtccttggtc tgactgacag gtgtcgcttt ttcatcaatg acattgaggt tgcgtcaaat     1920

atcacgtcat ttgcagtata tgatgagttt ttattgttga caacccattc ccatacctgc     1980

cagtgttttt gcctgaggga tgcttcattt aaaacattac aggccggcct gagcagcaat     2040

catgtgtccc atggggaagt tctgcggaaa gtggagaggg gttcacggat tgtcactgtt     2100

gtgccccagg acacaaagct tgtattacag atgccaaggg gaaacttaga agttgttcat     2160

catcgagccc tggttttagc tcagattcgg aagtggttgg acaaacttat gtttaaagag     2220

gcatttgaat gcatgagaaa gctgagaatc aatctcaatc tgatttatga tcataaccct     2280

aaggtgtttc ttggaaatgt ggaaaccttc attaaacaga tagattctgt gaatcatatt     2340

aacttgtttt ttacagaatt gaaagaagaa gatgtcacga agaccatgta ccctgcacca     2400

gttaccagca gtgtctacct gtccagggat cctgacggga ataaaataga ccttgtctgc     2460

gatgctatga gagcagtcat ggagagcata aatcctcata aatactgcct atccatactt     2520

acatctcatg taaagaagac aaccccagaa ctggaaattg tactgcaaaa agtacacgag     2580

cttcaaggaa atgctccctc tgatcctgat gctgtgagtg ctgaagaggc cttgaaatat     2640

ttgctgcatc tggtagatgt taatgaatta tatgatcatt ctcttggcac ctatgacttt     2700

gatttggtcc tcatggtagc tgagaagtca cagaaggatc ccaaagaata tcttccattt     2760

cttaatacac ttaagaaaat ggaaactaat tatcagcggt ttactataga caaatacttg     2820

aaacgatatg aaaaagccat tggccacctc agcaaatgtg gacctgagta cttcccagaa     2880

tgcttaaact tgataaaaga taaaaacttg tataacgaag ctctgaagtt atattcacca     2940

agctcacaac agtaccagga tatcagcatt gcttatgggg agcacctgat gcaggagcac     3000

atgtatgagc cagcggggct catgtttgcc cgttgcggtg cccacgagaa agctctctca     3060

gcctttctga catgtggcaa ctggaagcaa gccctctgtg tggcagccca gcttaacttt     3120

accaaagacc agctggtggg cctcggcaga actctggcag gaaagctggt tgagcagagg     3180

aagcacattg atgcggccat ggttttggaa gagtgtgccc aggattatga agaagctgtg     3240

ctcttgctgt tagaaggagc tgcctgggaa gaagctttga ggctggtata caaatataac     3300

agactggata ttatagaaac caacgtaaag ccttccattt tagaagccca gaaaaattat     3360

atggcatttc tggactctca gacagccaca ttcagtcgcc acaagaaacg tttattggta     3420

gttcgagagc tcaaggagca agcccagcag gcaggtctgg atgatgaggt accccacggg     3480

caagagtcag acctcttctc tgaaactagc agtgtcgtga gtggcagtga gatgagtggc     3540

aaatactccc atagtaactc caggatatca gcgagatcat ccaagaatcg ccgaaaagcg     3600

gagcggaaga agcacagcct caaagaaggc agtccgctgg aggacctggc cctcctggag     3660

gcactgagtg aagtggtgca gaacactgaa aacctgaaag atgaagtata ccatatttta     3720

aaggtactct ttctctttga gtttgatgaa caaggaaggg aattacagaa ggcctttgaa     3780

gatacgctgc agttgatgga aaggtcactt ccagaaattt ggactcttac ttaccagcag     3840

aattcagcta ccccggttct aggtcccaat tctactgcaa atagtatcat ggcatcttat     3900

cagcaacaga agacttcggt tcctgttctt gatgctgagc tttttatacc accaaagatc     3960

aacagaagaa cccagtggaa gctgagcctg ctagactga                            3999


<210>  1331
<211>  3117
<212>  DNA
<213>  homo sapiens

<400>  1331
atggacccca acaccattat cgaggccctg cggggcacta tggacccagc cctgcgtgag       60

gccgcggagc gccagctcaa tgaagcacac aagtctctga attttgtctc aacactgctc      120

cagattacta tgtcggaaca gctggattta cctgtgagac aggcaggtgt tatctatctg      180

aaaaatatga taacacagta ttggcctgat cgagaaacag caccagggga tatatcccct      240

tatactattc cagaagaaga tcgccattgt attcgagaaa atattgtaga agccattatc      300

cattctcctg agctcatcag ggtacagctt actacatgca ttcatcacat catcaaacat      360

gattatccaa gccgctggac tgccattgtg gacaaaattg gcttttatct tcagtccgat      420

aacagtgctt gttggctagg aattcttctt tgcctttatc agcttgtgaa aaattatgag      480

tataaaaaac cagaggagcg gagtccattg gtagcagcaa tgcagcattt tctgccagtt      540

ctaaaggatc gttttatcca gcttctttct gaccagtctg atcagtctgt cctcatccag      600

aaacagatat tcaagatctt ctatgctctt gttcagtata cactaccact ggaactgata      660

aaccaacaga acctgacaga atggatagaa attttaaaga ctgttgtgaa cagggatgta      720

cctaatgaaa cacttcaagt tgaagaagat gatcgacctg agttaccatg gtggaaatgc      780

aagaagtggg ccttacatat tttagcaaga ctttttgaaa gatatggaag ccctggcaat      840

gtttccaagg agtataatga atttgctgaa gtatttctga aggcatttgc tgttggtgtc      900

cagcaagttt tattgaaggt gttatatcag tacaaggaga agcaatatat ggctcctcga      960

gttttacaac agacattaaa ttatattaat caaggagttt ctcatgctct cacctggaag     1020

aatctgaagc cccatataca aggcattatc caagatgtta tttttccatt gatgtgctat     1080

acagatgctg atgaggaact ttggcaagaa gacccttacg aatatatacg catgaagttt     1140

gatgtgtttg aagatttcat ttctcctacc actgctgccc agacactttt gtttacagcc     1200

tgtagtaaga ggaaagaggt actgcaaaag actatgggat tttgttacca gattcttaca     1260

gaaccaaatg ctgaccctcg aaaaaaagat ggagccctgc atatgattgg ctctttagct     1320

gaaatacttc tgaagaaaaa gatctataaa gatcagatgg aatacatgtt gcagaatcat     1380

gtattccctc tcttcagcag tgaactaggc tacatgagag caagggcttg ctgggtactt     1440

cactattttt gtgaagtgaa gttcaaaagt gatcagaacc ttcaaacagc cttagagcta     1500

acaagaagat gtctgattga tgatagagaa atgcctgtga aagtggaagc tgccattgcc     1560

cttcaagtat tgatcagcaa tcaagaaaaa gctaaagaat atatcacacc attcatcaga     1620

cctgtaatgc aggctcttct tcacattata agagaaacag aaaatgatga ccttaccaat     1680

gtaattcaga aaatgatctg tgaatatagt gaagaagtta ctcctattgc agtagaaatg     1740

acacaacatt tggcaatgac atttaaccaa gtaatccaga cggggccaga tgaagaaggt     1800

agtgatgaca aagcagttac tgctatggga attctgaata caattgatac acttcttagt     1860

gtagttgaag atcataaaga gataacccaa cagcttgagg gaatctgctt acaggtcatt     1920

ggtactgttt tacaacagca tgtcttagaa ttctatgagg agatcttctc tttagcgcac     1980

agtttgacat gtcaacaagt gtctccacag atgtggcagc tactacccct tgtatttgaa     2040

gtctttcagc aagatggctt tgattacttt acagatatga tgcccctcct tcataattat     2100

gtaacagttg atacagacac acttctgtct gacaccaagt atcttgaaat gatatacagt     2160

atgtgcaaaa aggttcttac aggagttgca ggagaagatg cagagtgtca tgcagcaaaa     2220

ttgttagagg tcatcattct gcagtgcaaa gggcgtggca ttgaccagtg cattccctta     2280

ttcgtggaag cagccttaga aagactgaca agagaggtta agacaagtga acttcgaact     2340

atgtgtctgc aagttgcaat tgcagctttg tattataatc cacacctact actcaatacc     2400

ttagaaaatc ttcgcttccc taataatgtt gaaccagtta caaatcattt tattacacag     2460

tggcttaatg atgttgactg tttcttgggg cttcatgaca gaaagatgtg tgttctcgga     2520

ctctgtgctc ttattgatat ggaacagata ccccaagttt taaatcaggt ttctggacag     2580

attttgccgg cttttatcct tttatttaac ggattgaaaa gagcatatgc ctgccatgca     2640

gaacatgaga atgacagtga tgatgatgat gaagctgaag atgatgatga aaccgaggaa     2700

ctggggagtg atgaagatga tattgatgaa gatgggcaag aatatttgga gattctggct     2760

aagcaggctg gtgaagatgg agatgatgaa gattgggaag aagatgatgc tgaagagact     2820

gctctggaag gctattccac aatcattgat gatgaagata accctgttga tgagtatcag     2880

atatttaaag ctatctttca aactattcaa aatcgtaatc ctgtgtggta tcaggcactg     2940

actcacggtc ttaatgaaga acaaagaaaa cagttacagg acatagcaac tctggctgat     3000

caaagaagag cagcccatga atccaaaatg attgagaagc atggaggata caaattcagt     3060

gctccagttg tgccaagttc tttcaatttt ggaggcccag caccagggat gaattga        3117


<210>  1332
<211>  1797
<212>  DNA
<213>  homo sapiens

<400>  1332
atgaagccaa caggtacaga cccaaggatc ttatctatag ctgctgaagt tgcaaaaagc       60

cctgagcaga atgtccctgt tatactgttg aagttaaaag aaataataaa catcacacct      120

ttaggaagct cagagttgaa gaaaatcaaa caagatatat attgttatga tctcattcaa      180

tattgcctct tggtcctcag tcaagattat tctcgaatcc agggtggttg gactacaatt      240

tcccagctta cacagatatt aagccattgc tgtgtgggct tggagccagg agaagatgca      300

gaggaatttt acaatgaatt acttccatca gctgcagaaa attttctagt tttggggaga      360

caattacaaa catgttttat caatgcagct aaggctgaag aaaaagatga attactacac      420

tttttccaaa ttgtgactga ttctctcttc tggcttttgg gaggccatgt tgaacttatt      480

cagaatgtac tacaaagtga tcatttctta catttactgc aagctgacaa tgtccaaata      540

ggatctgcag tcatgatgat gctacagaat atactacaga tcaacagtgg tgatttactc      600

agaataggaa gaaaagccct gtattcaatt ttagatgaag ttattttcaa gcttttttca      660

actcctagtc cagttataag aagtactgct acaaaactcc tactgttgat ggctgaatcc      720

catcaggaaa ttttgatttt actgagacaa agtacctgct acaaaggact cagacgtcta      780

ctaagtaaac aggaaactgg gactgaattc agtcaagaac ttagacagct tgttggcctt      840

ttaagcccaa tggtctatca ggaagtagaa gagcagaaac tacatcaagc agcatgcttg      900

attcaagcct attggaaggg ttttcagaca agaaagagat taaagaagct tccatctgct      960

gtgattgctt tgcagaggag tttcagatcc aaacgatcaa agatgttgct ggagataaat     1020

aggcagaagg aagaagagga cctcaaatta caattgcaac ttcaaagaca gagagccatg     1080

agactttccc gagaattgca gctgagtatg ctcgaaatag ttcatccagg tcaggtggag     1140

aaacactatc gggaaatgga agagaaatca gcactgatta tccagaaaca ttggagaggg     1200

tacagggaaa ggaaaaattt tcaccaacag aggcagtctc tcatagagta taaagcagct     1260

gtcacacttc aaagagcagc gcttaaattc ctagcgaagt gccgtaagaa aaagaaacta     1320

tttgctcctt ggcgaggact ccaagaactc actgatgcac gccgagttga actgaagaaa     1380

cgagtggatg actatgtcag aagacatttg ggctctccaa tgtcagatgt ggtcagtagg     1440

gagctccatg cccaagctca agaacgactg caacactact ttatgggcag ggccctagaa     1500

gagcgagccc agcagcacag agaagctctg atagcacaga tcagcaccaa cgttgaacag     1560

ctaatgaagg caccaagtct gaaggaggca gaagggaaag aacctgagct cttcctaagt     1620

agatccaggc ctgtggcagc caaggccaag caggcccatc tcacaaccct gaagcacata     1680

caagcaccct ggtggaagaa gcttggagaa gaatctggag atgagattga tgttccaaag     1740

gatgagctta gtatagaatt agaaaattta ttcattggtg gaaccaaacc accttag        1797


<210>  1333
<211>  2892
<212>  DNA
<213>  homo sapiens

<400>  1333
atgtggtgcc tgcactgcaa ctcggagagg acccagtccc ttctggagct agagcttgac       60

agcggcgtcg agggcgaggc ccccagcagt gagactggca catccctgga cagcccctca      120

gcctaccccc agggcccctt ggtgcccggt tccagcctga gcccggatca ctacgagcac      180

acgtcagtgg gagcctatgg gctgtactcg gggccgccgg ggcaacagca gcgcacgcgg      240

aggcccaagc tgcagcactc gacctccatc ctgcgcaagc aggctgagga ggaggccatc      300

aagcgctcac gctcactctc cgagagctat gagctctcct cggacctgca ggacaagcag      360

gtggagatgc tagaacgaaa gtatgggggg cgcctggtaa cccgccatgc ggcccgcacc      420

atccagacgg cgtttcgcca gtaccagatg aacaagaact tcgagcgctt gcgcagctcc      480

atgtcagaga accgcatgtc acgccggatt gtgctgtcca acatgaggat gcagttctcc      540

tttgaggggc ctgagaaagt gcacagctcc tacttcgagg ggaagcaggt ctcagtgact      600

aacgacggct cccagctggg agccctggtg tcccctgagt gtggtgacct cagcgagccc      660

accaccctca agtctccggc cccctccagt gactttgcgg acgccatcac cgagctggag      720

gacgccttct ctaggcaagt gaaatcactg gccgagtcca tcgacgatgc cctcaactgc      780

cgcagcctgc acactgagga ggcaccggcc ctggatgcgg cgcgggcccg ggacaccgaa      840

ccccagacag ccctgcacgg catggaccac cgcaaactgg acgagatgac ggcctcgtac      900

agtgatgtca ccctgtacat cgatgaggag gagctgtcgc cccctctgcc cctctcgcag      960

gcaggggacc ggccgtccag caccgagtcg gacctgcggc tacgggctgg gggcgcagcc     1020

ccagactact gggccctggc ccacaaagag gacaaggctg acacggacac gagctgccgg     1080

agcacgccgt cgctggagcg gcaggagcag cggctgcggg tggagcatct gccgctgctc     1140

accatcgagc cacccagcga cagctctgtg gaccttagtg accgctcgga gcgggggtca     1200

ctcaagaggc agagtgctta cgagcgcagc cttggcgggc agcagggcag tcccaagcat     1260

ggtccccaca gcggcgcccc caagagcctc ccccgggagg agcctgagtt gcggccccgg     1320

ccccccaggc ccctggacag ccacttggcc atcaatggct cagccaaccg gcagagcaag     1380

tctgagtcgg actactcaga cggtgacaat gacagcatca acagcacgtc caactccaac     1440

gataccatca actgcagctc cgagtcatcg tcccgtgaca gcctgcggga gcagacgctc     1500

agcaagcaga cctaccacaa ggaggcccgc aacagctggg actcgcctgc ctttagcaac     1560

gatgtcatcc gcaagaggca ctaccgcatc ggcctgaacc tcttcaacaa gaagcctgag     1620

aagggagtcc agtacctcat cgagcgtggc tttgtgcccg acacgcccgt cggggtggcc     1680

cacttcctgc tgcagcgcaa gggcctcagc cggcagatga tcggcgagtt cctgggcaac     1740

cggcagaagc agttcaaccg tgacgtgctc gactgcgtcg tggacgagat ggacttctct     1800

accatggagc tggatgaggc cctcaggaaa ttccaggcgc acatccgtgt ccaaggggag     1860

gctcagaaag tggagcggct catagaggcg ttcagccagc gctactgcat ctgcaaccct     1920

ggggtggtgc ggcaattccg gaacccagac accattttca tcctggcctt cgccatcatc     1980

ctgctgaaca ccgacatgta cagccccaat gtcaagcccg agcggaaaat gaagctagag     2040

gacttcatca agaacctccg aggtgtggac gatggtgagg acattccccg tgagatgctg     2100

atggggatct atgaacggat ccgtaagcga gagctaaaga ccaatgagga ccatgtgtcc     2160

caggtgcaga aggtggagaa gctcattgtg gggaaaaagc cgatcggatc cctgcatccc     2220

gggctcggct gtgtgctctc tctgccccac cgtcggttgg tctgctactg ccggctcttt     2280

gaggttccag acccaaacaa gccccagaaa ctcggactac accagcgaga aatcttcctg     2340

ttcaacgacc tcctggtggt caccaagatc ttccagaaga agaagaactc ggtgacgtac     2400

agcttccgac agtccttctc cttgtacggc atgcaggtcc tgctcttcga gaaccagtac     2460

taccccaatg gcatccggct cacctcgtct gtccccggag cagatatcaa agtgttaata     2520

aacttcaacg cccccaaccc tcaagaccgg aagaaattca ccgatgacct gcgggagtcc     2580

attgcggaag tccaagagat ggagaagcac aggatagagt cggagctcga gaagcagaaa     2640

ggcgtcgtgc ggcccagcat gtcccagtgc tctagcctca aaaaggagtc gggcaacgga     2700

acactgagcc gggcctgcct ggacgacagc tatgccagcg gtgagggcct caagcgcagc     2760

gccctcagca gctccctgcg ggacctctcg gaagccggga agcgagggcg tcgcagcagt     2820

gcgggatcgc tagagagcaa tgtggaattt cagcctttcg agccactgca gccgtcagtg     2880

ctgtgctcct aa                                                         2892


<210>  1334
<211>  1146
<212>  DNA
<213>  homo sapiens

<400>  1334
atgtcccgac atgaaggtgt cagctgtgat gcatgtttaa aaggaaattt tcgaggtcgc       60

agatataagt gtttaatttg ctacgattac gatctttgtg catcttgtta tgaaagtggt      120

gcaacaacaa caaggcatac aactgaccac ccaatgcagt gcatattaac aagggtagat      180

tttgatttat actatggtgg ggaagctttc tctgtagagc agccacagtc ttttacttgt      240

ccctattgtg gaaaaatggg ctatacggag acatctcttc aagaacatgt tacttctgaa      300

catgcagaaa catcaacaga agtgatttgt ccaatatgtg cagcgttacc tggaggcgat      360

cctaatcatg tcacggatga ctttgcagct catcttacac ttgaacacag agcccctaga      420

gatttagatg aatcgagtgg tgttcgacat gtacgtagaa tgtttcaccc tggccgggga      480

ttaggaggtc ctcgtgctcg tagatcaaac atgcacttta ctagcagttc tactggtgga      540

ctttcttctt ctcagagttc atattctcca agcaataggg aagccatgga tcctatagct      600

gagcttttat ctcagttatc aggagtgaga cgttctgcag gaggacagct taattcctct      660

ggcccttccg cttctcagtt acaacaactg cagatgcagc tgcagctaga acggcagcat      720

gcccaggcag cacggcaaca actggagacc gcacgcaacg caacccggcg tactaacaca      780

agcagtgtca ccactacaat cacacaatcc acagcaacaa ccaacatagc taatacagaa      840

agcagtcagc agactctaca gaattcccag tttcttttaa caaggttgaa tgatcctaaa      900

atgtctgaaa cggagcgcca gtccatggaa agcgagcgtg cagaccgcag cctgtttgtc      960

caagagctcc ttctgtccac tttagtgcgt gaagagagct catcctcaga tgaggatgat     1020

cggggggaga tggcagattt tggtgctatg ggctgtgtag atattatgcc tttagatgtt     1080

gctttagaaa acctaaattt aaaagagagt aataaaggaa atgagcctcc accacctcct     1140

ctttga                                                                1146


<210>  1335
<211>  1752
<212>  DNA
<213>  homo sapiens

<400>  1335
atgactttct atttgtttgg tattcgaagc tttccgaagc tttggaagag cccatacctt       60

gggctaggcc cagggcactc ttatgtctcg ctgtttctgg cagaccgctg tggcatcagg      120

aaccagcaga ggttgttttc tcttaaaaca atgtctccac agaataccaa agcaacgaat      180

ctgattgcca aggccagata tctcaggaaa gatgagggca gtaataagca agtttattct      240

gttcctcatt tttttttagc tggagcagct aaggagagat cacagatgaa ttctcaaact      300

gaagatcatg ccttggcacc tgtgaggaac actattcaac tcccaacaca acctttgaat      360

tcagaggagt gggataaact taaggaagat ttaaaagaaa acaccggaaa gaccagtttc      420

gaaagttgga tcatttcaca gatggctggc tgtcatagct ctatagatgt ggctaaatct      480

ctgctggcat gggtagcagc caaaaataat ggtattgtaa gttacgattt actggtcaag      540

tatttgtatc tctgtgtctt tcatatgcag acatctgaag ttattgatgt ctttgaaatt      600

atgaaagcca gatataagac tttagaacct agaggttaca gtcttctcat ccggggattg      660

atccattcag acagatggag agaagcattg ttgctgttag aggacatcaa aaaagttata      720

actccttcaa aaaagaacta taatgactgt atccagggag ctctccttca tcaagatgta      780

aacacagctt ggaatttata tcaggaattg ctaggtcatg atattgttcc tatgttggaa      840

actttaaaag ctttctttga ttttggaaaa gacataaagg atgataacta ttcaaataaa      900

ctactagata ttctttcata tctaagaaat aatcagctgt atccagggga gtcatttgca      960

cacagtataa aaacatggtt tgagagtgtt cctggaaaac aatggaaagg acaattcacc     1020

acagtccgaa aaagtggcca gtgttcgggc tgtggaaaaa ccatagagtc tattcagctg     1080

agtccagaag aatatgaatg tcttaaggga aaaatcatga gggatgtgat agatggaggt     1140

gaccagtaca gaaagacaac acctcaggaa cttaagagat ttgagaactt cataaaatct     1200

cgtcctcctt ttgatgttgt cattgatggt ctcaatgttg ccaaaatgtt tcctaaagtt     1260

cgtgaatctc aacttctctt gaatgtcgtc tctcaactag ccaaacggaa tctgcgactg     1320

ctggtcctag gccggaagca catgctaaga cggagttccc agtggagtcg ggatgagatg     1380

gaagaggtgc aaaagcaagc cagctgtttt tttgctgatg acatctcgga ggatgatcca     1440

ttccttctgt atgccacact gcactccggg aatcactgca ggtttatcac aagagacctg     1500

atgcgggacc acaaggcctg tctgcctgat gccaagaccc aacgcctgtt ttttaagtgg     1560

cagcagggac atcagctggc aattgtaaat aggtttccag gatcaaaact aacctttcag     1620

cgtattctca gctatgacac agtggtgcaa acaactggag actcgtggca cataccatat     1680

gatgaagact tggtagaaag atgttcctgt gaagtaccaa ccaaatggct ttgcctccac     1740

caaaagacat ag                                                         1752


<210>  1336
<211>  1830
<212>  DNA
<213>  homo sapiens

<400>  1336
atggaaggaa agccaatgcg caggtgtacc aacattcgac caggagagac tggaatggat       60

gtaacaagcc gctgcaccct tggagacccc aacaaactgc cagaaggggt tccccaacct      120

gcccgcatgc cctatatctc agacaagcac cctcgacaaa ccttggaagt gattaacctt      180

ctgagaaagc accgggagct atgtgatgtg gtgctagttg tgggcgccaa gaagatatat      240

gcccatcgag tcattttgtc agcctgtagt ccctacttcc gagctatgtt tacaggagaa      300

ttggcagaga gccgtcagac agaagtagtg atccgagaca ttgacgagag ggctatggaa      360

ttactgattg actttgcgta tacctcccag ataacagtag aagagggcaa tgttcagact      420

cttctgccag ctgcttgcct cctccagctg gcagaaatac aggaagcctg ctgtgaattc      480

ttaaagagac aattagatcc ttctaactgc ctgggcattc gggcttttgc tgacacacat      540

tcatgtcgtg agttgctaag gatagcagac aagttcaccc aacataactt tcaagaggta      600

atggagagtg aagagttcat gttgcttcca gccaatcaac tcattgatat aatatccagt      660

gatgagctaa acgttcgcag tgaagaacaa gtgttcaatg cagtgatggc ctgggtcaaa      720

tacagtattc aggaaagacg tcctcaatta ccccaggtgc tgcagcatgt tcgtttgcct      780

ttgcttagtc ccaagttcct ggtcggcaca gtaggctctg atcccctcat caaaagtgat      840

gaagaatgca gagacttggt agatgaggct aaaaactacc tcctattgcc gcaagaacga      900

ccactaatgc aaggaccaag gacgagacca cggaaaccta tccgatgtgg ggaagtactc      960

tttgcagttg gtggttggtg cagtggagat gccatttcca gtgttgaacg atatgatcca     1020

cagaccaatg aatggagaat ggtggcttca atgagcaaaa ggagatgcgg agttggggtc     1080

agtgttcttg atgatctgtt atatgcagta ggaggccatg atggatcctc ttatctcaat     1140

agtgttgaaa ggtatgaccc caaaacaaac cagtggagca gtgatgtggc ccctacaagc     1200

acctgcagga caagtgttgg tgtagcagta cttggaggct ttctttatgc tgtgggtggc     1260

caggatggtg tgtcttgcct caacattgtt gagaggtatg atccgaagga gaacaagtgg     1320

actcgggtag cttctatgag taccagaaga ctaggtgtgg ctgtggctgt gttaggaggg     1380

ttcttatatg ctgtaggtgg ctctgacggg acatctcctc tcaacacagt ggaacgttac     1440

aatcctcagg aaaacagatg gcacactata gcccctatgg ggacccggag gaaacaccta     1500

ggctgtgcag tatatcagga catgatctat gctgtaggag gtagagatga cactacagag     1560

ctgagcagtg ctgagagata caaccccaga accaaccagt ggtctccagt ggtggccatg     1620

acatcacgcc gtagtggagt tggcctggca gtggtcaatg gacagctcat ggcagtagga     1680

ggttttgatg gcacaacata cttgaagacc atagaagttt ttgatcctga tgccaataca     1740

tggaggttat atggcgggat gaattaccgt cggctagggg gtggcgtagg agttattaaa     1800

atgacacatt gtgaatccca tatttggtga                                      1830


<210>  1337
<211>  1803
<212>  DNA
<213>  homo sapiens

<400>  1337
atggtactaa tattgggacg cagactaaac agagaggatc ttggggtgcg tgattcccca       60

gcaactaagc gaaaagtttt tgaaatggac cccaaatctc tgacaggtca tgagtttttt      120

gacttctctt caggatcatc ccatgccgaa aacatactcc agatatttaa tgaatttcgt      180

gatagccgct tattcacaga tgttatcatt tgtgtggaag gaaaagaatt tccttgccat      240

agagctgtgc tctcagcctg tagcagctac ttcagagcta tgttttgtaa tgaccacagg      300

gaaagccgag aaatgttggt tgagatcaat ggtattttag ctgaagctat ggaatgtttt      360

ttgcagtatg tttatactgg aaaggtgaag atcactacag agaatgtaca gtatctcttt      420

gagacatcaa gcctctttca gattagtgtt ctccgtgatg catgtgccaa gttcttggag      480

gagcaacttg atccttgtaa ttgcttagga atccagcgct ttgctgatac ccattcactc      540

aaaacactct tcacaaaatg caaaaatttt gcgttacaga cttttgagga tgtatcccag      600

cacgaagaat ttcttgagct tgacaaagat gaacttattg attatatttg tagtgatgaa      660

cttgttattg gtaaagagga gatggttttt gaagccgtca tgcgttgggt ctatcgtgcc      720

gttgatctga gaagaccact gttacacgag ctcctgacac atgtgagact ccctctgttg      780

catcccaact actttgttca aacagttgaa gtggaccaat tgatccagaa ttctcctgag      840

tgttatcagt tgttgcatga agcaagacgg taccacatac ttgggaatga aatgatgtcc      900

ccaaggacta ggccacgcag gtccactggc tattctgagg tgatagttgt cgttggagga      960

tgtgagcgag ttggaggatt taatcttcca tacactgagt gctacgatcc tgtaacagga     1020

gaatggaagt ctttggctaa gcttccagaa tttaccaaat cagagtatgc agtctgtgct     1080

ctaaggaatg acattcttgt ttcaggtgga agaatcaaca gccgtgatgt ctggatttat     1140

aactcacagt taaatatttg gatcagagtt gcctctctca ataaaggcag atggcgtcac     1200

aaaatggctg tcctccttgg taaagtatat gttgtcggtg gctatgatgg gcaaaacaga     1260

cttagcagcg tagaatgtta tgattccttt tcaaatcgat ggactgaagt tgctcccctt     1320

aaggaagccg tgagttctcc tgcagtgact agctgtgtag gcaaactgtt tgtgattggt     1380

ggaggacctg atgataatac ttgttctgat aaggttcaat cttatgatcc agaaaccaat     1440

tcttggctac ttcgtgcagc tatcccaatt gccaaaaggt gtataacagc tgtatcccta     1500

aacaacctga tctatgttgc cggtggactg accaaggcaa tatactgtta cgatccagtt     1560

gaagattact ggatgcacgt acagaataca ttcagccgtc aggaaaactg tggtatgtct     1620

gtgtgtaatg gtaaaatata tatcctgggc ggaagacggg aaaatggaga agccacagac     1680

actattctct gttatgatcc tgcaacaagt atcatcacag gggtagctgc aatgcccagg     1740

ccagtgtcct atcatggctg tgtgactatt catagataca atgagaaatg ctttaaactc     1800

tga                                                                   1803


<210>  1338
<211>  2211
<212>  DNA
<213>  homo sapiens

<400>  1338
atgggaaatc cagaaaacat agaagatgca tatgttgctg ttattcgtcc aaagaatact       60

gccagtctca attctcggga atacagagct aagtcatatg aaattttgtt gcatgaagtt      120

cccattgaag gacagaaaaa aaagagaaag aaagttttat tggaaacgaa acttcaaggc      180

aacagtgaaa taacacaagg catattggat tacgtagtag aaaccaccaa accaatttct      240

cctgcaaacc agggtatcag aggaaaacga gttgtactaa tgaaaaaatt tcctctggat      300

ggagagaaga tgggcagaga agcatcatta tttattgttc catcagttgt caaagataat      360

actaaataca catatacccc aggatgccca attttttact gcttacaaga tattatgcga      420

gtctgtagtg aatccagtac tcattttgct acacttacag caaggatgtt aatagccttg      480

gataagtggt tagatgaacg tcatgcacaa tctcacttta ttccagcttt attccgacct      540

tctcctcttg agcggataaa aactaatgtc ataaatcctg catatgctac tgaatcaggt      600

cagacagaaa actcactaca tatgggctat agtgcactag aaataaagag taaaatgtta      660

gccctagaga aagcagatac ctgtatttac aaccctttgt ttggatcaga tcttcagtat      720

acaaatcggg tagataaagt ggtaataaat ccatactttg gtctaggagc tccagactac      780

tcaaaaatcc aaatacctaa acaggaaaaa tggcagagaa gcatgagcag tgtcacagaa      840

gacaaggaac gacagtgggt agatgatttt cctctccacc gaagcgcctg tgaaggagat      900

tcagaattac taagccgtct tctcagtgaa agattttcag tcaaccagtt agatagtgac      960

cactgggcac ccattcatta tgcatgctgg tatggaaaag ttgaggccac tcgcatattg     1020

ttagagaaag gaaagtgcaa tccaaacctt ttaaatggac aacttagttc tcctcttcat     1080

tttgctgctg gaggaggaca tgctgaaata gtacagattc tcctaaacca cccagaaacg     1140

gatagacata taacagacca acaaggaaga tctccattaa atatttgtga agaaaacaaa     1200

caaaacaact gggaagaagc tgcaaaattg ttgaaggaag caattaacaa accatatgaa     1260

aaagttcgaa tatacagaat ggatgggtca tatcgttctg ttgaattgaa gcatggaaat     1320

aataccacag tgcagcagat aatggaagga atgcgtctct ctcaagaaac tcagcaatat     1380

ttcactatat ggatttgttc agaaaacctc agccttcaac tcaaaccata tcataaaccc     1440

ttgcaacatg ttcgtgactg gccagaaata cttgctgaat tgactaatct ggatcctcaa     1500

agggaaacac ctcagctttt tctaagaaga gatgtgagac ttcccttgga agttgaaaaa     1560

cagattgaag acccactagc tattcttatt ctctttgatg aagccagata taatttattg     1620

aagggctttt atacagctcc tgatgctaag ctgataacat tggcaagtct gcttttgcaa     1680

atagtctatg gaaattatga gagtaaaaaa cacaagcaag gtttcctaaa tgaagaaaat     1740

ctaaaatcca tcgtacctgt taccaaactg aaaagtaagg cacctcactg gacaaatcgc     1800

atacttcatg aatacaagaa tctcagtaca agtgaaggtg tcagtaaaga aatgcatcac     1860

cttcagcgca tgttcttaca gaattgctgg gaaattccta cttatggagc agcatttttc     1920

acaggacaga tatttacaaa ggcaagcccc agcaatcata aagtcatccc tgtgtatgta     1980

ggagtgaata taaaaggact tcatctcctc aacatggaaa ctaaggcttt actcatcagt     2040

cttaagtatg gttgttttat gtggcaattg ggagatactg atacttgttt tcagatccat     2100

agcatggaaa ataaaatgag ctttatagta catacaaaac aggctggtct cgtggtaaaa     2160

ctgttaatga agctaaatgg acagttaatg cccactgaaa gaaattcatg a              2211


<210>  1339
<211>  1200
<212>  DNA
<213>  homo sapiens

<400>  1339
atggctcaaa gggccttccc gaatccttat gctgattata acaaatccct ggccgaaggc       60

tactttgatg ctgccgggag gctgactcct gagttctcac aacgcttgac caataagatt      120

cgggagcttc ttcagcaaat ggagagaggc ctgaaatcag cagaccctcg ggatggcacc      180

ggttacactg gctgggcagg tattgctgtg ctttacttac atctttatga tgtatttggg      240

gaccctgcct acctacagtt agcacatggc tatgtaaagc aaagtctgaa ctgcttaacc      300

aagcgctcca tcaccttcct ttgtggggat gcaggccccc tggcagtggc cgctgtgcta      360

tatcacaaga tgaacaatga gaagcaggca gaagattgca tcacacggct aattcaccta      420

aataagattg atcctcatgc tccaaatgaa atgctctatg ggcgaatagg ctacatctat      480

gctcttcttt ttgtcaataa gaactttgga gtggaaaaga ttcctcaaag ccatattcag      540

cagatttgtg aaacaatttt aacctctgga gaaaacctag ctaggaagag aaacttcacg      600

gcaaagtctc cactgatgta tgaatggtac caggaatatt atgtaggggc tgctcatggc      660

ctggctggaa tttattacta cctgatgcag cccagccttc aagtgagcca agggaagtta      720

catagtttgg tcaagcccag tgtagactac gtctgccagc tgaaattccc ttctggcaat      780

taccctccat gtataggtga taatcgagat ctgcttgtcc attggtgcca tggcgcccct      840

ggggtaatct acatgctcat ccaggcctat aaggtattca gagaggaaaa gtatctctgt      900

gatgcctatc agtgtgctga tgtgatctgg caatatgggt tgctgaagaa gggatatggg      960

ctgtgccacg gttctgcagg gaatgcctat gccttcctga cactctacaa cctcacacag     1020

gacatgaagt acctgtatag ggcctgtaag tttgctgaat ggtgcttaga gtatggagaa     1080

catggatgca gaacaccaga cacccctttc tctctctttg aaggaatggc tggaacaata     1140

tatttcctgg ctgacctgct agtccccaca aaagccaggt tccctgcatt tgaactctga     1200


<210>  1340
<211>  3060
<212>  DNA
<213>  homo sapiens

<400>  1340
atgctttgga gggtgctttt gtcaaagagg cctcctttcc ctcacccaga gctggatttc       60

caagaggctc ccatacctag ctgccctggc agactcccag ggaggaaaaa cagcgtggcc      120

ttggcagctg ccccgaggaa ggagcccaca ggtgacaggg agaagccatt gccattccct      180

gtcctggccc ccttcagcaa ccctgaacac tctgctccag ccaaggtggt gagggcagct      240

gttcctaaac agcgcaaagg cagcaaggtt ggtgactttg gagatgcaat caattggccc      300

acacctggag agatagccca caagagtgtt cagccacagt cccacaagcc tcagcctacc      360

cgtaaactgc cacccaagaa ggacatgaag gaacaggaga aaggagaagg gagtgatagt      420

aaggagagtc caaaaaccaa atcagatgaa tcaggggagg aaaagaatgg agatgaggat      480

tgccagcgag gcgggcagaa gaagaaagga aacaaacaca agtgggttcc attacaaata      540

gacatgaagc ctgaagtgcc cagagagaaa ctggcttcac gccccactcg cccaccggag      600

cctagacaca tacctgccaa tcgcggagag atcaaagggt ctgagtctgc cacctacgtg      660

cccgtggccc cccccacccc agcctggcaa ccagagatca aaccggagcc tgcctggcac      720

gaccaggatg agacatcgag tgtgaagagt gatggggctg gtggggcgcg ggcttccttc      780

cgtggccgtg gacgggggcg tggtcgcggc cggggacgcg gccggggtgg cactcgaacc      840

cattttgact accagtttgg ctaccgaaag tttgatggtg tggaggggcc tcgtacgccc      900

aagtacatga acaacatcac ctactacttt gacaatgtca gcagcaccga gctttacagt      960

gtggatcagg aactgctcaa agactacatc aagcgccaga ttgaatacta cttcagcgtg     1020

gacaatttag agcgagactt cttcctgcga aggaaaatgg atgctgatgg tttcctaccc     1080

atcaccctta ttgcttcctt ccaccgagtg caggccctta ccactgacat ttcactcatc     1140

tttgcggccc taaaggacag caaggtggtg gagatcgttg atgagaaagt tcgtaggagg     1200

gaggaaccag aaaagtggcc tcttccccca atagtggatt attcacagac tgatttctcc     1260

cagcttctca actgccctga atttgttccc cgtcagcact accaaaagga gacagagtcg     1320

gcacctggct ctcctcgtgc agtcacccca gtgccaacca aaacagagga ggtcagcaac     1380

ctaaagacac tacccaaggg cctgtctgcc agcctgcctg acctggattc tgagaactgg     1440

attgaagtga agaagaggcc tcggccatcc ccagcacggc ccaagaagtc agaggagtcc     1500

agattttccc acctgacctc tctgcctcag cagctgcctt cccagcagct gatgtccaag     1560

gatcaggatg agcaagagga actggatttt ctgtttgacg aggagatgga gcagatggat     1620

gggcggaaga acaccttcac tgcctggtct gatgaggaat ctgactatga gattgatgac     1680

agggatgtca acaagatcct cattgtcacc cagacaccac attacatgcg ccggcaccca     1740

gggggggacc gcacaggcaa ccacacctcg cgtgccaaga tgagcgccga actggccaag     1800

gtcattaatg atggcctctt ctactatgag caggacctgt gggctgaaaa gtttgaacct     1860

gagtattccc agatcaagca agaagtcgag aacttcaaaa aggtcaatat gatcagccgg     1920

gagcagtttg acacactgac ccctgagccc cctgtggatc ccaaccagga agttcctcct     1980

gggccacctc ggttccagca agttcctacg gatgccctgg ccaacaagtt gtttggtgct     2040

cctgagccct ccaccatcgc ccgctctcta ccaaccactg tcccagagtc accaaactac     2100

cgcaacacca ggacccctcg cactccccgg acaccacagc tcaaagactc aagccagaca     2160

tcacggtttt acccagtggt gaaagaagga cggacactgg atgccaagat gcctcgaaaa     2220

agaaagacaa gacacagttc aaacccaccc ttggagagcc atgtgggctg ggtgatggat     2280

tcccgtgagc acaggccccg tactgcttcc atcagctcca gcccctcaga agggacgcct     2340

acagttggca gctatggctg tacccctcag tcattgccca agttccagca tccttcccat     2400

gaactgctca aggaaaatgg cttcacacaa cacgtctacc ataagtatcg taggcgctgc     2460

cttaatgagc ggaaacgctt gggcattggc cagtctcagg agatgaacac actcttccgc     2520

ttctggtcct tcttcctccg agatcacttc aacaaaaaga tgtatgagga gttcaagcag     2580

ctggctctgg aggacgccaa agaaggctac agatatggtt tggagtgcct ttttcgatac     2640

tacagttatg gcctggaaaa gaagttccgg ctggacatat tcaaggattt tcaggaggaa     2700

acggtgaagg actatgaagc tggccaactg tatgggctgg agaagttctg ggccttcttg     2760

aaatattcca aagccaaaaa tttggacatt gaccccaaac tgcaagaata cctcggcaaa     2820

ttccgacgtc ttgaagactt ccgagtagat ccccccatgg gtgaggaggg caaccacaag     2880

cgacactcag tggtagcagg aggtggcggc ggtgagggca ggaagcggtg cccctcccag     2940

tcttccagca ggcctgctgc catgatcagc caacccccta caccacccac cggccagcct     3000

gtccgggaag atgccaaatg gacaagccag cactcgaaca cacagacttt gggaaagtga     3060


<210>  1341
<211>  2175
<212>  DNA
<213>  homo sapiens

<400>  1341
atgttgcttt tcgtggagca ggtagcatct aaaggaactg gtttaaatcc taatgccaaa       60

gtatggcaag aaattgctcc tggaaatact gatgccaccc cagtaactca tggaactgaa      120

agctcttggc atgaaatagc agctacatca ggtgctcatc ctgagggtaa tgcagagctc      180

tcagaagata tatgtaaaga atatgaagta atgtattctt catcttgtga aaccacaaga      240

aatactacag gcattgaaga atcaactgat gggatgattt taggaccaga agatctgagt      300

taccaaatat atgatgtttc cggagaaagc aattcagcag tttctacaga agacctaaaa      360

gaatgtctga agaaacaatt agaattctgt ttttcacgag aaaatttgtc aaaggatctt      420

tacttgatat ctcaaatgga tagtgatcag ttcatcccaa tttggacagt tgccaacatg      480

gaagaaataa aaaagttgac tacagaccct gatctaattc ttgaagtgtt aagatcttct      540

cccatggtac aagttgatga gaagggtgag aaagtgagac caagtcataa gcgttgtatt      600

gtaattctta gagagattcc tgaaacaaca ccaatagagg aagtgaaagg tttgttcaaa      660

agtgaaaact gccccaaagt gataagctgt gagtttgcac acaatagcaa ctggtatatc      720

actttccagt cagacacaga tgcacaacag gcttttaaat acttaagaga agaagttaaa      780

acatttcagg gcaagccaat tatggcaagg ataaaagcca tcaatacatt ttttgctaag      840

aatggttatc gattaatgga ttctagtatc tatagtcacc ccattcaaac tcaagcacag      900

tatgcctccc cagtctttat gcagcctgta tataatcctc accaacagta ctcggtctat      960

agtattgtgc ctcagtcttg gtctccaaat cctacacctt actttgaaac accactggct     1020

ccctttccca atggtagttt tgtgaatggc tttaattcgc caggatctta taaaacaaat     1080

gctgctgcta tgaatatggg tcgaccattc caaaaaaatc gtgtgaagcc tcagtttagg     1140

tcatctggtg gttcagaaca ctcaacagag ggctctgtat ccttggggga tggacagttg     1200

aacagatata gttcaagaaa ctttccagct gaacggcata accccacagt aactgggcat     1260

caggagcaaa cttaccttca gaaggagact tccactttgc aggtggaaca gaatggggac     1320

tatggtaggg gcaggagaac tctcttcaga ggtcgaagac gacgagaaga tgacaggatc     1380

tcaagacctc atccttcaac agctgaatca aaggctccaa caccaaagtt tgacttatta     1440

gcctcaaatt ttccaccttt acctggaagt tcatcaagaa tgccaggtga actcgttttg     1500

gagaatagga tgtctgatgt tgttaaaggt gtctacaaag aaaaggataa tgaagagttg     1560

acaattagtt gcccagtgcc tgcagatgag cagacagaat gcacttctgc ccagcaactc     1620

aatatgagta ccagttctcc atgtgctgct gagcttactg cattaagcac aactcagcaa     1680

gaaaaggatc taatagaaga ttcctctgtt cagaaggatg gtctcaatca gacaactata     1740

ccagtttctc ctccaagtac tacaaagcca tcgagggcaa gtactgcttc accatgtaat     1800

aataacataa atgcagctac agctgtggct ctacaggaac cccgaaagtt aagttatgct     1860

gaagtgtgcc agaagccccc taaagagcca tcttcagttc ttgtgcagcc actacgggaa     1920

cttcgctcca atgtggtgtc tcccaccaaa aatgaagaca atggagctcc tgagaactcc     1980

gttgagaaac cacatgagaa gccagaagca agggctagta aggattattc tggcttccga     2040

ggcaatataa tccccagggg agcagcagga aaaatcaggg aacagagacg ccagtttagc     2100

catagggcta tacctcaggg agtgactcga cgtaatggca aagagcaata tgtgccaccc     2160

agatcaccaa agtaa                                                      2175


<210>  1342
<211>  2577
<212>  DNA
<213>  homo sapiens

<400>  1342
atgtttaccc ttgcggaagt tgcatcactt aatgacattc agccaactta ccgaatcctg       60

aaaccatggt gggatgtgtt tatggattac ctagctgttg ttatgttaat ggtagccatc      120

tttgcaggaa ccatgcaact taccaaagat caggtggtct gtttgccagt attgccatct      180

cctgtaaatt caaaggcaca tacaccacca ggaaatgccg aggtcaccac caacatccca      240

aagatggaag cagccaccaa ccaagaccaa gatgggcgga caacaaacga catttccttt      300

gggacatctg ctgtgacacc tgacatacct ctcagagcca catatcctcg cacagatttc      360

gcacttccaa atcaggaggc aaagaaagag aagaaagatc caacaggtcg aaaaacaaac      420

ttggattttc agcaatatgt atttattaat caaatgtgtt accatctggc ccttccgtgg      480

tattctaagt actttccata cctagctctt atacatacta ttattctcat ggtcagtagc      540

aacttttggt tcaaatatcc caaaacatgc tcaaaagtag aacattttgt ttcaatatta      600

ggaaagtgct ttgaatcccc ttggacgaca aaagcgttgt ctgagacagc atgcgaagac      660

tcagaggaaa acaagcagag aataacaggt gcccagactc taccaaagca tgtttctacc      720

agcagtgatg aagggagccc cagtgccagt acaccaatga tcaataaaac tggctttaaa      780

ttttcagctg agaagcctgt gattgaagtt cccagcatga caatcctgga taaaaaggat      840

ggagagcagg ccaaagccct gtttgagaaa gtgaggaagt tccgtgccca tgtggaagat      900

agtgacttga tctataaact ctatgtggtc caaacagtta tcaaaacagc caagttcatt      960

tttattctct gctatacagc gaactttgtc aacgcaatca gctttgaaca cgtctgcaag     1020

cccaaagttg agcatctgat tggttatgag gtatttgagt gcacccacaa tatggcttac     1080

atgttgaaaa agcttctcat cagttacata tccattattt gtgtttatgg ctttatctgc     1140

ctctacactc tcttctggtt attcaggata cctttgaagg aatattcttt cgaaaaagtc     1200

agagaagaga gcagttttag tgacattcca gatgtcaaaa acgattttgc gttccttctt     1260

cacatggtag accagtatga ccagctatat tccaagcgtt ttggtgtgtt cttgtcagaa     1320

gttagtgaaa ataaacttag ggaaattagt ttgaaccatg agtggacatt tgaaaaactc     1380

aggcagcaca tttcacgcaa cgcccaggac aagcaggagt tgcatctgtt catgctgtcg     1440

ggggtgcccg atgctgtctt tgacctcaca gacctggatg tgctaaagct tgaactaatt     1500

ccagaagcta aaattcctgc taagatttct caaatgacta acctccaaga gctccacctc     1560

tgccactgcc ctgcaaaagt tgaacagact gcttttagct ttcttcgcga tcacttgaga     1620

tgccttcacg tgaagttcac tgatgtggct gaaattcctg cctgggtgta tttgctcaaa     1680

aaccttcgag agttgtactt aataggcaat ttgaactctg aaaacaataa gatgatagga     1740

cttgaatctc tccgagagtt gcggcacctt aagattctcc acgtgaagag caatttgacc     1800

aaagttccct ccaacattac agatgtggct ccacatctta caaagttagt cattcataat     1860

gacggcacta aactcttggt actgaacagc cttaagaaaa tgatgaatgt cgctgagctg     1920

gaactccaga actgtgagct agagagaatc ccacatgcta ttttcagcct ctctaattta     1980

caggaactgg atttaaagtc caataacatt cgcacaattg aggaaatcat cagtttccag     2040

catttaaaac gactgacttg tttaaaatta tggcataaca aaattgttac tattcctccc     2100

tctattaccc atgtcaaaaa cttggagtca ctttatttct ctaacaacaa gctcgaatcc     2160

ttaccagtgg cagtatttag tttacagaaa ctcagatgct tagatgtgag ctacaacaac     2220

atttcaatga ttccaataga aataggattg cttcagaacc tgcagcattt gcatatcact     2280

gggaacaaag tggacattct gccaaaacaa ttgtttaaat gcataaagtt gaggactttg     2340

aatctgggac agaactgcat cacctcactc ccagagaaag ttggtcagct ctcccagctc     2400

actcagctgg agctgaaggg gaactgcttg gaccgcctgc cagcccagct gggccagtgt     2460

cggatgctca agaaaagcgg gcttgttgtg gaagatcacc tttttgatac cctgccactc     2520

gaagtcaaag aggcattgaa tcaagacata aatattccct ttgcaaatgg gatttaa        2577


<210>  1343
<211>  16293
<212>  DNA
<213>  homo sapiens

<400>  1343
atgtcttcct cagatgaaga gacgctcagt gagcggtcat gtcggagtga gcggtcttgt       60

cggagtgagc gatcttacag gagcgagcgg tcggggagcc tgtctccctg tcccccaggg      120

gacaccttgc cctggaacct gccactgcat gagcagaaaa agcggaaaag ccaggattcg      180

gtgctggacc ctgcagagcg tgctgtggtc agagtcgctg atgaacggga ccgggttcag      240

aagaaaacgt tcaccaagtg ggtcaacaag cacttaatga aggtccgcaa gcacatcaat      300

gatctttatg aagatctgcg ggatggccat aacctgatct ctctgttgga ggtcctctca      360

ggcatcaaac tgccccggga gaagggcagg atgcgttttc ataggctgca gaatgtgcag      420

attgccctgg acttcctaaa gcagcgacag gtgaaactag tgaatattcg caatgatgac      480

atcacagatg gcaaccccaa gttgaccctg ggtctgatct ggaccattat tttgcatttc      540

cagatctctg acatctacat tagtggagaa tcaggggata tgtcagccaa ggagaaacta      600

ctcctgtgga cccagaaggt gacagctggt tacacaggaa tcaaatgcac caacttttcc      660

tcctgctgga gtgatgggaa gatgttcaat gcactcattc accgataccg acccgatcta      720

gtagacatgg agagggtgca aatccaaagt aaccgagaga atctggaaca ggcttttgaa      780

gtggcagaaa gactgggggt cactcgcctg ctggatgcag aagatgtgga tgtgccatct      840

ccagatgaaa agtctgtaat cacttatgtg tcttcgattt atgatgcctt ccctaaagtt      900

cctgagggtg gagaagggat cagtgctacg gaagtggact ccaggtggca agaataccaa      960

agccgagtgg actccctcat tccctggatc aaacagcata caatactgat gtcagataaa     1020

acttttcccc aaaaccctgt tgaactaaag gcactttata accaatatat acacttcaaa     1080

gaaacagaaa ttctggccaa ggagagagaa aaaggaagaa ttgaggaatt atataaatta     1140

ctagaggtgt ggattgaatt tggccgaatt aaactgcctc aaggttatca ccctaatgat     1200

gtggaagaag agtggggaaa gctcatcata gagatgctgg aacgagagaa atcacttcgg     1260

ccggctgtgg agaggctgga attgctgcta cagattgcaa acaaaatcca gaatggtgct     1320

ttgaactgtg aagaaaaact gacactagct aagaatacac tgcaggctga tgctgctcac     1380

ctggaatcag gacaaccggt acaatgtgag tcagatgtca ttatgtacat tcaggagtgt     1440

gaaggtctca tcaggcagct gcaggtggat ctccagatcc tgcgggatga gaattactac     1500

cagctagaag agctggcttt tagggtcatg cgtcttcagg atgagctggt caccttgcgt     1560

ctagagtgta caaacctgta ccggaagggt catttcactt cacttgaatt ggttccaccc     1620

tctactttaa ccaccactca tctgaaagca gaacccttaa ccaaggcaac ccattcttct     1680

tctacctcct ggttccgaaa gcctatgact cgggctgaac ttgtggccat cagctcctct     1740

gaagatgaag gcaatctccg atttgtgtat gaactactgt cttgggtaga agagatgcag     1800

atgaaactgg agcgagcaga gtggggcaat gacctgccta gtgtggagtt gcagctagaa     1860

acacagcagc acatccatac gagtgtagaa gagctgggct caagtgtcaa ggaggccagg     1920

ttgtatgagg gaaagatgtc ccagaatttc cataccagct atgctgaaac tcttggaaag     1980

ctggagacac agtattgtaa attgaaggaa acttctagct tccggatgag gcaccttcag     2040

agcctgcata aatttgtttc cagagctaca gctgagttga tctggttgaa tgagaaggag     2100

gaggaggaac tagcatatga ctggagtgac aacaattcca atatctcagc caagagaaat     2160

tacttctctg agttgacaat ggaactggag gagaaacagg atgtgtttcg ttctctacaa     2220

gatacagcag aactactttc acttgagaac cacccagcca agcagacagt ggaggcttac     2280

agtgctgctg tccagtccca gttgcagtgg atgaagcagc tgtgcctgtg tgttgagcag     2340

catgtgaaag agaatactgc ttattttcag ttcttcagtg atgcacgaga gctggagtca     2400

ttcttgagga acctccaaga ttccattaaa cgaaaatatt cctgtgacca caacaccagc     2460

ttatcccgcc ttgaagacct gctccaggac tccatggatg aaaaggagca gcttatacag     2520

tccaagagtt ccgttgccag tctcgttggg agatcaaaaa ccatcgttca gctaaaacca     2580

cgcagtccag accatgtgtt aaagaacacc atttctgtca aggctgtctg tgactacagg     2640

cagatcgaga ttactatttg caaaaatgat gaatgtgtgc tagaagataa ttctcagcgg     2700

accaaatgga aagtgatcag ccccacaggg aacgaggcaa tggtgccgtc agtctgcttc     2760

ctcatccccc cacccaataa ggatgccatt gagatggcca gcagggtcga acaatcttat     2820

cagaaggtta tggccctttg gcatcagctg catgttaaca ccaaaagcct tatctcttgg     2880

aactatctgc gtaaagacct tgaccttgta cagacctgga acctagaaaa gcttcgatcc     2940

tcagcaccag gggagtgcca tcagattatg aagaaccttc aggcccacta tgaagacttt     3000

ctgcaggata gtcgtgactc tgtgctgttc tcagtggctg atcgcttgcg cttggaagag     3060

gaggtggaag cttgtaaagc ccgcttccag cacctgatga agtccatgga gaatgaggac     3120

aaagaggaga ctgtggccaa gatgtacatt tcagagttga agaacatccg gctacgcctg     3180

gaggagtatg aacagagggt ggtcaaacga attcagtctc tagccagctc taggactgac     3240

agagatgcct ggcaggacaa tgcattaagg attgcagagc aagagcacac ccaggaggat     3300

ttacagcaat tgaggtcaga cttggatgca gtttctatga aatgtgacag ctttctccat     3360

cagtctccat ctagttcaag tgtcccaact ctgcgctcag aactgaatct gctggtggag     3420

aagatggacc atgtctatgg tctctctact gtatatctga ataagttaaa gacagttgat     3480

gttatagtac gtagcataca ggatgctgaa ctcttggtca aaggttatga gattaagctg     3540

agtcaagaag aagtagtact ggcagatctc tcagctctgg aggcccattg gtcgacatta     3600

cggcactggc ttagtgatgt gaaggacaag aattcagtgt tttcagtcct ggatgaggaa     3660

attgccaagg ccaaggtagt ggcagagcag atgagtcgtc tgacaccaga gcgaaatctg     3720

gatttggagc gctatcagga aaaaggctcc cagctgcagg agcgttggca ccgagtcatt     3780

gcccagctcg agattcgcca atctgagcta gaaagtatcc aggaagttct gggagattac     3840

cgagcctgcc atggaactct catcaagtgg attgaggaaa ccactgccca gcaggaaatg     3900

atgaagccag gccaggcaga ggatagcaga gtgctttcgg agcagctcag ccagcagacg     3960

gccctatttg cagaaattga gagaaatcag acaaaactgg atcaatgtca aaaattttcc     4020

cagcagtact ctactattgt aaaggactat gaattgcaac tgatgacata caaggccttt     4080

gtggaatcgc agcagaaatc ccctggcaag cgccgtcgca tgctttcctc ttcagatgcc     4140

atcactcaag agttcatgga cttaaggact cgctacacgg cattggtgac tttaacaact     4200

cagcacgtga aatacatcag tgatgcactc cggcgtctgg aggaggagga gaaagtggta     4260

gaagaggaga aacaagaaca tgtggagaag gttaaagaac ttttgggctg ggtgtctacc     4320

ctagcgagga atacacaagg aaaagctacc tcatccgaga ccaaagaatc aacagacatt     4380

gaaaaagcta ttttggaaca gcaggttctg tcagaagagc tgacaacaaa gaaagaacaa     4440

gtctctgaag ctattaaaac atcacagatc ttcttggcca agcatggtca taagctctca     4500

gaaaaagaga agaaacaaat atctgagcaa ttgaatgccc taaacaaggc ttaccatgac     4560

ctttgtgatg gttctgcaaa tcagcttcag cagcttcaga gccagttggc tcaccagaca     4620

gaacaaaaga ccctgcagaa acaacaaaat acctgtcacc agcaactgga ggatctttgc     4680

agttgggtag gacaggcaga aagagcactg gcaggccacc aaggcagaac cacccagcag     4740

gatctctctg ctttgcagaa gaaccaaagt gacttgaagg atttacagga tgacattcag     4800

aatcgtgcca cctcatttgc cactgttgtc aaggacattg aggggttcat ggaagagaat     4860

cagaccaagc tgagcccacg tgagttgaca gctcttcggg aaaagcttca tcaggctaag     4920

gagcaatatg aggcgctcca ggaagagaca cgtgtggccc agaaggaact ggaggaagca     4980

gtgacctccg ccttacagca ggagactgaa aagagtaaag cagcaaagga actggcagag     5040

aacaagaaga agatcgatgc tctcctggat tgggtaactt cagtaggatc atctggtgga     5100

cagctgctga ccaaccttcc aggaatggag cagctctcgg gagctagctt ggagaaagga     5160

gccttggaca ccactgatgg ttacatgggg gtgaatcaag ccccagagaa actggacaag     5220

caatgtgaga tgatgaaggc ccgtcaccaa gaattgctgt cccagcagca aaatttcatt     5280

ctggccaccc agtcagctca ggccttcttg gatcagcatg gccacaatct cacacctgag     5340

gagcaacaga tgctgcaaca gaagctggga gagctaaagg aacaatactc tacttccctg     5400

gcccaatcag aggcagaact gaagcaggtg cagacacttc aggatgagtt gcagaaattt     5460

ctgcaggatc ataaagagtt tgaaagctgg ttggaacgat ccgagaaaga gctggagaac     5520

atgcataagg gaggcagcag ccccgagacc cttccctccc tgctaaagcg gcaaggaagc     5580

ttctcagagg atgtcatttc ccacaaagga gacttgagat ttgtgactat ctcaggacag     5640

aaagtcttgg acatggaaaa cagttttaag gaaggcaaag aaccatcaga aattggaaac     5700

ttagtaaagg acaagttgaa ggatgcaaca gaaagataca ctgctctcca ctcaaagtgt     5760

acacgattag gatctcacct gaatatgctg ttaggccagt atcatcaatt ccaaaacagt     5820

gctgacagcc tgcaggcctg gatgcaggct tgtgaggcca acgtggagaa gctcctctca     5880

gatactgttg cctctgaccc tggagttctc caggagcagc ttgcaacaac aaagcagttg     5940

caggaggaat tggctgagca ccaagtacct gtggaaaaac tccaaaaagt agctcgtgac     6000

ataatggaaa ttgaagggga gccagcccca gaccacaggc atgttcaaga aactacagat     6060

tccatactca gccacttcca aagcctctcc tatagcctgg ctgagcgatc ttctctgctg     6120

cagaaagcaa ttgcccaatc tcagagtgtc caggaaagcc tggagagcct gttgcagtct     6180

attggggaag ttgaacaaaa cctggaaggg aagcaggtgt catcactctc atcaggagtc     6240

atccaggaag ccttagccac aaatatgaaa ttgaagcagg acattgctcg gcaaaagagc     6300

agcttggagg ccacccgtga gatggtgacc cgattcatgg agacagcaga cagtactaca     6360

gcagcagtgc tgcagggcaa actggcagag gtgagccagc ggttcgaaca gctctgtcta     6420

cagcagcaag aaaaggagag ctccctaaag aagcttctac cccaggcaga gatgtttgaa     6480

cacctctctg gtaagctgca gcagttcatg gaaaacaaaa gtcggatgct ggcctctgga     6540

aatcagccag atcaagatat tacacatttc ttccaacaga tccaggagct caatttggaa     6600

atggaagacc aacaggagaa cctagatact cttgagcacc tggtcactga actgagctct     6660

tgtggctttg cgctggactt gtgccagcat caggacaggg tacagaatct aagaaaagac     6720

ttcacagagc tacagaagac agttaaagag agagagaaag atgcatcatc ttgccaggaa     6780

cagttggatg aattccggaa gctggtcagg accttccaga aatggttgaa agaaactgaa     6840

gggagtattc cacctacgga aacttctatg agtgctaaag agttagaaaa gcagattgaa     6900

cacctgaaga gtctactaga tgactgggca agtaagggaa ctctggtgga agaaatcaat     6960

tgcaaaggta cttctttaga aaatctcatc atggaaatca cagcacctga ttcccaaggc     7020

aagacaggtt ccatactgcc ctctgtagga agctctgtag gcagtgtaaa cggataccac     7080

acctgcaaag atctgacgga gatccagtgt gacatgtcag atgtaaactt gaagtatgag     7140

aaactagggg gagtacttca tgaacgccag gaaagccttc aggctatcct caacagaatg     7200

gaggaggttc acaaggaggc aaactctgtg ctgcagtggc tggaatcaaa agaggaagtc     7260

ctgaaatcca tggatgccat gtcatctcca accaagacag aaacagtgaa agcccaagct     7320

gaatctaaca aggccttcct ggctgagttg gaacagaatt ctccaaaaat tcaaaaagta     7380

aaggaagccc tggctggatt actggtgaca tatcccaact cacaggaagc agaaaattgg     7440

aagaaaattc aggaagaact caattcccga tgggaaaggg ccactgaggt tactgtggct     7500

cggcaaaggc agctagagga atctgcaagt catctggcct gcttccaggc tgcagaatcc     7560

cagctccggc cgtggctgat ggagaaagaa ctgatgatgg gagtgctggg gcccctgtct     7620

attgacccca acatgttgaa tgcacaaaag caacaggtcc agtttatgct aaaggaattt     7680

gaagcacgca ggcaacagca tgagcaactg aatgaggcag ctcagggcat cctaacaggc     7740

cctggagatg tctctctgtc caccagccaa gtacagaaag aactccagag catcaatcag     7800

aaatgggttg agctgactga caaactcaac tcccgttcca gccaaattga ccaagctatt     7860

gttaagagca cccagtacca ggaactgctc caggacttat cagagaaggt gagggcagtt     7920

ggacaacggc tgagtgtcca gtcagctatc agcacccaac cagaggctgt aaagcagcaa     7980

ttggaagaga ccagtgaaat tcgatctgac ttggagcagt tagaccacga ggttaaggag     8040

gctcagacac tgtgcgatga actctcagtg ctcattggtg agcagtacct caaggatgaa     8100

ctgaagaagc gtttggagac agttgccctg cctctccaag gtttagaaga ccttgcagcc     8160

gatcgcatta acagactcca ggcagctctt gccagcaccc agcagttcca gcaaatgttt     8220

gatgagttga ggacctggtt ggatgataaa caaagccagc aagcaaaaaa ctgcccaatt     8280

tctgcaaaat tggagcggct acagtctcag ctacaggaga atgaagagtt tcagaaaagt     8340

cttaatcaac acagtggctc ctatgaggtg attgtggctg aaggggaatc tctacttctt     8400

tctgtacctc ctggagaaga gaaaaggact ctacaaaacc agttggttga gctcaaaaac     8460

cattgggaag agcttagtaa aaaaactgca gacagacaat ccaggctcaa ggattgtatg     8520

cagaaagctc agaaatatca gtggcatgtg gaagaccttg tgccatggat agaagattgt     8580

aaagctaaga tgtctgagtt gcgagtcact ctggatccag tgcagctaga gtccagtctc     8640

ctaagatcaa aggctatgct gaatgaggtg gagaagcgcc gctccctgct ggaaatattg     8700

aatagtgctg ctgacattct gatcaattct tcagaagcag atgaggatgg aatccgggat     8760

gagaaggctg ggatcaacca gaacatggat gctgttacag aagagctgca ggccaaaaca     8820

gggtcactcg aagaaatgac tcagaggctc agggagttcc aggaaagctt taagaatatt     8880

gaaaagaagg ttgaaggagc caaacaccaa cttgagatct ttgatgctct gggttctcaa     8940

gcctgtagca acaagaacct ggagaagcta agagctcaac aggaagtgct gcaggcccta     9000

gagcctcagg tagactatct gaggaacttt actcagggtc tggtagaaga tgccccagat     9060

ggatctgatg cttctcaact tctccaccaa gctgaggtcg cccagcaaga gttcctcgaa     9120

gttaagcaaa gagtgaacag tggttgtgtg atgatggaaa acaagctgga ggggattggc     9180

cagtttcact gccgggtccg agagatgttc tctcaattgg cagacctgga tgatgagcta     9240

gatggcatgg gtgctattgg cagagacact gatagcctcc agtcccaaat cgaggatgtc     9300

cggctattcc ttaacaaaat tcacgtcctc aaattagaca tagaggcctc tgaagcagag     9360

tgtcgacata tgctagaaga agaggggact ctggatttgt taggtctcaa aagggagcta     9420

gaagccctga acaaacagtg tggcaaactg acagagaggg ggaaagctcg tcaggaacag     9480

ctggaactga cactaggccg tgtagaggac ttctacagga aattgaaagg actcaatgac     9540

gcgaccacag cagcagagga ggcagaggcc ctccagtggg tagtggggac cgaagtggaa     9600

atcatcaacc aacaattagc agattttaaa atgtttcaga aagaacaagt ggatcctctt     9660

cagatgaaat tgcagcaggt gaatggactt ggccagggat taattcagag tgcaggaaaa     9720

gactgtgatg tacagggttt agaacatgac atggaagaga tcaatgctcg atggaataca     9780

ttgaataaaa aggtcgcaca aagaattgca cagctacagg aagctttgtt gcattgtggg     9840

aagtttcaag atgccttgga gccattgctc agctggttgg cagataccga ggagctcata     9900

gccaatcaga aacctccatc tgctgagtat aaagtggtga aagcacagat ccaagaacag     9960

aagttgctcc agcggctcct agatgatcga aaggccacag tagacatgct tcaagcagaa    10020

ggaggcagaa tagcccagtc agcagagctg gctgatagag agaaaatcac tggacagctg    10080

gagagtcttg aaagtagatg gactgaacta ctcagtaagg cagcagccag gcaaaaacag    10140

ctggaagaca tcctggttct ggccaaacag ttccatgaga cagctgagcc tatttctgac    10200

ttcttatctg tcacagagaa aaagcttgct aactcagaac ctgttggcac tcagactgcc    10260

aaaatacagc agcagatcat tcggcacaag gctctggaag aagacataga aaaccatgca    10320

acagatgtgc accaggcagt caaaattggg cagtccctct cctccctgac atctcctgca    10380

gaacagggtg tgctgtcaga aaagatagac tcattgcagg cccgatacag tgaaattcaa    10440

gaccgctgtt gtcggaaggc agccctactt gaccaagctc tgtctaatgc taggctgttt    10500

ggggaggatg aggtggaggt gctcaactgg ctggctgagg ttgaggacaa gctcagttca    10560

gtgttcgtaa aggatttcaa acaggatgtc ctgcacaggc agcatgctga ccacctggct    10620

ttaaatgaag aaattgttaa tagaaagaag aatgtagatc aagctattaa aaatggtcag    10680

gctcttctaa aacaaaccac aggtgaggag gtgttactta tccaggaaaa actagatggt    10740

ataaagactc gttacgcaga catcacagtt actagctcca aggccctcag aactttagag    10800

caagcccggc agctggccac caagttccag tctacttatg aggaactgac cgggtggctg    10860

agggaggtgg aggaggagct ggcaaccagt ggaggacagt ctcccacagg ggaacagata    10920

ccccagtttc agcagagaca gaaggaatta aagaaggagg tcatggagca caggctggtg    10980

ttggacacag tgaatgaggt gagccgtgct ctcttagagc tggtgccctg gagagccaga    11040

gaagggctgg ataaacttgt gtccgatgct aacgagcagt acaaactagt cagtgacact    11100

attggacaaa gggtggatga aattgatgct gctattcaga gatcacaaca gtatgagcaa    11160

gctgccgatg cagaactagc ttgggttgct gaaacaaaac ggaaactgat ggctctgggt    11220

ccaattcgcc tggaacagga ccagaccaca gctcagcttc aggtacagaa ggctttctcc    11280

attgacatta ttcgacacaa agattcaatg gatgaactct tcagtcaccg tagtgaaatc    11340

tttggcacat gtggggagga gcaaaaaact gtattacagg aaaagacaga gtctctaata    11400

cagcaatatg aagccattag cctactcaat tcagagcgtt atgcccgcct agagcgggcc    11460

caggtcttag taaaccagtt ttgggaaact tatgaagagc tcagcccctg gattgaggaa    11520

actcgggcac taatagcaca gttaccctct ccagccattg atcatgagca gctcaggcag    11580

caacaagagg aaatgaggca attaagggaa tctattgctg aacacaaacc tcatattgac    11640

aaactactaa agataggccc acaactaaag gaattaaacc ctgaggaagg ggaaatggtg    11700

gaagaaaaat accagaaagc agaaaacatg tatgcccaaa taaaggagga ggtgcgccag    11760

cgagccctgg ctctggatga agccgtgtcc cagtccacac agattacaga gtttcatgat    11820

aaaattgagc ctatgttgga gacactggag aatctttcct ctcgcctgcg tatgccacca    11880

ctgatccctg ctgaagtaga caagatcaga gagtgcatca gtgacaataa gagtgccacc    11940

gtggagctag aaaaactgca gccatccttt gaggccttga agcgccgtgg agaggagctt    12000

attggacgat ctcagggagc agacaaggat ctggctgcaa aagaaatcca ggataaattg    12060

gatcaaatgg tattcttctg ggaggacatc aaagctcggg ctgaagaacg agaaatcaaa    12120

tttcttgatg tccttgaatt agcagagaag ttctggtatg acatggcagc tctcctgacc    12180

accatcaaag acacccagga tattgtccat gacttggaaa gcccaggcat tgatccttcc    12240

atcatcaaac aacaggttga agctgctgag actattaagg aagagacaga tggtctgcat    12300

gaagagctgg agtttattcg gatccttgga gcagatttga tttttgcctg tggagaaact    12360

gagaagcctg aagtgaggaa gagcattgat gagatgaata atgcttggga gaacttaaac    12420

aaaacatgga aagagaggct agaaaaactt gaggatgcta tgcaagctgc tgtgcagtat    12480

caggacactc ttcaggctat gtttgactgg ctagataaca ctgtgattaa actctgcacc    12540

atgccccctg ttggcactga cctcaatact gttaaagatc agttaaatga aatgaaggag    12600

ttcaaagtag aagtttacca acagcaaatt gagatggaga agcttaatca ccagggtgaa    12660

ctgatgttaa agaaagctac tgatgagacg gacagagaca ttatacgaga accactgaca    12720

gaactcaaac acctctggga gaacctgggt gagaaaattg cccaccgaca gcacaaacta    12780

gaaggggctc tgttggccct tggtcagttc cagcatgcct tagaggaact aatgagttgg    12840

ctgactcata ccgaagagtt gttagatgct cagagaccaa taagtggaga cccaaaagtc    12900

attgaagttg agctcgcaaa gcaccatgtc ctaaaaaatg atgttttggc tcatcaagcc    12960

acagtggaaa cagtcaacaa agctggcaat gagcttcttg aatccagtgc tggagatgat    13020

gccagcagct taaggagccg tttggaagcc atgaaccaat gctgggagtc agtgttacag    13080

aaaacagagg agagggagca gcagcttcag tcaactctgc agcaggccca gggcttccac    13140

agtgaaattg aagatttcct cttggaactt actagaatgg agagccagct ttctgcatct    13200

aagcccacag gaggacttcc tgaaactgct agggaacagc ttgatacaca tatggaactc    13260

tattcccagc tgaaagccaa ggaagagact tataatcaac tacttgacaa gggcagactc    13320

atgcttctaa gccgtgacga ctctgggtct ggctccaaga cagaacagag tgtagcactt    13380

ttggagcaga agtggcatgt ggtcagcagt aagatggaag aaagaaagtc aaagctggaa    13440

gaggccctca acttggcaac agaattccag aattccctac aagaatttat caactggctc    13500

actctagcag agcagagttt aaacatcgct tctccaccaa gcctgattct aaatactgtc    13560

ctttcccaga tagaagagca caaggttttt gctaatgaag taaatgctca tcgagaccag    13620

atcattgagc tggatcaaac tgggaatcaa ttaaagttcc ttagccaaaa gcaggatgtt    13680

gttctgatca agaatttgtt ggtgagcgtg cagtctcgat gggagaaggt tgtccagcga    13740

tctattgaaa gagggcgatc actagatgat gccaggaagc gggcaaaaca attccatgaa    13800

gcttggaaaa aactgattga ctggctagaa gatgcagaga gtcacctgga ctcagaacta    13860

gagatatcca atgacccaga caaaattaaa cttcagcttt ctaagcataa ggagtttcag    13920

aagactcttg gtggcaagca gcctgtgtat gataccacaa ttagaactgg cagagcactg    13980

aaagaaaaga ctttgcttcc cgaagatagt cagaaacttg acaatttcct aggagaagtc    14040

agagacaaat gggatactgt ttgtggcaag tctgtggagc ggcagcacaa gttggaggaa    14100

gccctgctct tttcgggtca gttcatggat gctttgcagg cattggttga ctggttatac    14160

aaggtggagc cacagctggc tgaggaccag cccgtgcacg gggaccttga cctcgtcatg    14220

aacctcatgg atgcacacaa ggttttccag aaggaactgg gaaagcgaac aggaaccgtt    14280

caggtcctga agcggtcagg ccgagagctg attgagaata gtcgagatga caccacttgg    14340

gtaaaaggac agctccagga actgagcact cgctgggaca ctgtctgtaa actctctgtt    14400

tccaaacaaa gccggcttga gcaggcctta aaacaagcgg aagtgtttcg agacacagtc    14460

cacatgctgt tggagtggct ttctgaagca gagcaaacgc ttcgctttcg gggagcactt    14520

cctgatgaca cagaggccct gcagtctctc attgacaccc ataaggaatt catgaagaaa    14580

gtagaagaaa agcgagtgga cgttaactca gcagtagcca tgggagaagt catcctggct    14640

gtctgccacc ccgattgcat cacaaccatc aaacactgga tcaccatcat ccgagctcgc    14700

ttcgaggagg tcctgacatg ggctaagcag caccagcagc gtcttgaaac ggccttgtca    14760

gaactggtgg ctaatgctga gctcctggaa gaacttctgg catggatcca gtgggctgag    14820

accaccctca ttcagcggga tcaggagcca atcccgcaga acattgaccg agttaaagcc    14880

cttatcgctg agcatcagac atttatggag gagatgactc gcaaacagcc tgacgtggac    14940

cgggtcacca agacatacaa aaggaaaaac atagagccta ctcacgcgcc tttcatagag    15000

aaatcccgca gcggaggcag gaaatcccta agtcagccaa cccctcctcc catgccaatc    15060

ctttcacagt ctgaagcaaa aaacccacgg atcaaccagc tttctgcccg ctggcagcag    15120

gtgtggctgt tagcactgga gcggcaaagg aaactgaatg atgccttgga tcggctggag    15180

gagttgaaag aatttgccaa ctttgacttt gatgtctgga ggaaaaagta tatgcgttgg    15240

atgaatcaca aaaagtctcg agtgatggat ttcttccggc gcattgataa ggaccaggat    15300

gggaagataa cacgtcagga gtttatcgat ggcattttag catccaagtt ccccaccacc    15360

aagttagaga tgactgctgt ggctgacatt ttcgaccgag atggggatgg ttacattgat    15420

tattatgaat ttgtggctgc tcttcatccc aacaaggatg cgtatcgacc aacaaccgat    15480

gcagataaaa tcgaagatga ggttacaaga caagtggctc agtgcaaatg tgcaaaaagg    15540

tttcaggtgg agcagatcgg agagaataaa taccggtttg gggattctca gcagttgcgg    15600

ctggtccgta ttctgcgcag caccgtgatg gttcgcgttg gtggaggatg gatggccttg    15660

gatgaatttt tagtgaaaaa tgatccctgc cgagcacgag gtagaactaa cattgaactt    15720

agagagaaat tcatcctacc agagggagca tcccagggaa tgaccccctt ccgctcacgg    15780

ggtcgaaggt ccaaaccatc ttcccgggca gcttccccta ctcgttccag ctccagtgct    15840

agtcagagta accacagctg tacatccatg ccatcttctc cagccacccc agccagtgga    15900

accaaggtta tcccatcatc aggtagcaag ttgaaacgac caacaccaac ttttcattct    15960

agtcggacat cccttgctgg tgataccagc aatagttctt ccccggcctc cacaggtgcc    16020

aaaactaatc gggcagaccc taaaaagtct gccagtcgcc ctgggagtcg ggctgggagt    16080

cgagccggga gtcgagccag cagccggcga ggaagtgacg cttctgactt tgacctctta    16140

gagacgcagt ctgcttgttc cgacacttca gaaagcagcg ctgcaggggg ccaaggcaac    16200

tccaggagag ggctaaacaa accttccaaa atcccaacca tgtctaagaa gaccaccact    16260

gcctccccca ggactccagg tcccaagcga taa                                 16293


<210>  1344
<211>  1389
<212>  DNA
<213>  homo sapiens

<400>  1344
atggcaaagt ttcggagaag gacttgcatc attttggcac tttttattct atttattttc       60

tctctgatga tgggtttaaa aatgctgaga ccaaatacag ctacttttgg agctcctttt      120

ggacttgacc ttcttccaga acttcatcaa cgaactattc atttggggaa aaattttgat      180

ttccaaaaga gtgacagaat caacagtgaa acaaatacca agaatttaaa aagtgttgaa      240

atcactatga aaccttccaa agcctctgaa cttaacttgg atgaactacc acctctgaac      300

aattatctac atgtatttta ttacagttgg tatggaaatc cacaatttga tggtaaatat      360

atacattgga atcatccagt gttagagcat tgggacccta gaatagccaa gaattatcca      420

caagggagac acaaccctcc agatgacatt ggctccagct tttatcctga attgggaagt      480

tacagttctc gggatccttc tgtcatagaa actcacatga gacaaatgcg ctcagcttca      540

attggtgtac tagccctctc ttggtaccca cctgatgtaa atgatgaaaa tggagaacct      600

actgataact tggtacccac tattttggat aaagctcata aatataacct aaaggttact      660

tttcacatag aaccatatag caatcgagat gatcaaaaca tgtacaaaaa tgtcaagtat      720

attatagaca aatatggaaa tcatccggcc ttttacaggt acaagacgaa gactggcaat      780

gctcttccta tgttttatgt ctatgattcc tatattacca agcctgaaaa atgggccaat      840

ctgttaacca cctcagggtc tcggagtatt cgcaattctc cttatgatgg actgtttatt      900

gcccttctgg tagaagaaaa acataagtat gatattcttc aaagtggttt tgatggaatt      960

tacacatatt ttgccacaaa tggctttact tatggctcat cacatcagaa ttgggctagc     1020

ctaaaattat tttgtgataa atacaactta atatttatcc caagtgtggg cccaggatac     1080

atagatacca gcatccgtcc atggaacacg caaaacactc ggaaccgaat caatgggaag     1140

tattatgaaa ttggtctgag tgccgcactt cagacacgcc ccagcttaat ttctatcacc     1200

tcttttaatg agtggcatga aggaactcag attgaaaaag ctgttcccaa aagaaccagt     1260

aatacagtgt acctagatta ccgtcctcat aaaccaggtc tttacctaga actgactcgc     1320

aagtggtctg aaaaatacag taaggaaaga gcaacttatg cattagatcg ccagctgcct     1380

gtttcttaa                                                             1389


<210>  1345
<211>  1005
<212>  DNA
<213>  homo sapiens

<400>  1345
atgtctgaac caatcagagt ccttgtgact ggagcagctg gtcaaattgc atattcactg       60

ctgtacagta ttggaaatgg atctgtcttt ggtaaagatc agcctataat tcttgtgctg      120

ttggatatca cccccatgat gggtgtcctg gacggtgtcc taatggaact gcaagactgt      180

gcccttcccc tcctgaaaga tgtcatcgca acagataaag aagacgttgc cttcaaagac      240

ctggatgtgg ccattcttgt gggctccatg ccaagaaggg aaggcatgga gagaaaagat      300

ttactgaaag caaatgtgaa aatcttcaaa tcccagggtg cagccttaga taaatacgcc      360

aagaagtcag ttaaggttat tgttgtgggt aatccagcca ataccaactg cctgactgct      420

tccaagtcag ctccatccat ccccaaggag aacttcagtt gcttgactcg tttggatcac      480

aaccgagcta aagctcaaat tgctcttaaa cttggtgtga ctgctaatga tgtaaagaat      540

gtcattatct ggggaaacca ttcctcgact cagtatccag atgtcaacca tgccaaggtg      600

aaattgcaag gaaaggaagt tggtgtttat gaagctctga aagatgacag ctggctcaag      660

ggagaatttg tcacgactgt gcagcagcgt ggcgctgctg tcatcaaggc tcgaaaacta      720

tccagtgcca tgtctgctgc aaaagccatc tgtgaccacg tcagggacat ctggtttgga      780

accccagagg gagagtttgt gtccatgggt gttatctctg atggcaactc ctatggtgtt      840

cctgatgatc tgctctactc attccctgtt gtaatcaaga ataagacctg gaagtttgtt      900

gaaggtctcc ctattaatga tttctcacgt gagaagatgg atcttactgc aaaggaactg      960

acagaagaaa aagaaagtgc ttttgaattt ctttcctctg cctga                     1005


<210>  1346
<211>  630
<212>  DNA
<213>  homo sapiens

<400>  1346
atgaagaaag taaggcttaa ggaactagag agtcgcctgc aacaagtgga tggatttgaa       60

aagcccaagc tacttctgga acagtatcct accaggccgc acattgcagc atgtatgctc      120

tatacaatcc ataacactta tgatgacatt gaaaataaag tcgttgcaga tctaggatgt      180

ggttgtggag tacttagcat cggaactgca atgttaggag cagggttgtg tgttggattt      240

gacatagatg aagacgcatt ggaaatattt aataggaatg cagaagagtt tgagttaaca      300

aatattgaca tggttcaatg tgatgtgtgc ttattatcta acagaatgtc caagtcattc      360

gatacagtaa ttatgaatcc tccctttggg accaaaaata ataaagggac agatatggct      420

tttctaaaga ctgctttgga aatggcaaga acagcagtat attccttaca caaatcctca      480

actagagaac atgttcaaaa gaaagctgca gaatggaaaa tcaagataga tattatagca      540

gaacttcgat atgacctgcc agcatcatac aagtttcaca aaaagaaatc agtggacatt      600

gaagtggacc taattcggtt ttccttttaa                                       630


<210>  1347
<211>  3084
<212>  DNA
<213>  homo sapiens

<400>  1347
atggtctcta gcgaccggcc cgtgtcactg gaggacgagg tctcccatag tatgaaggag       60

atgattggag gctgttgcgt ttgctcagac gagagaggct gggccgagaa cccgctggtt      120

tattgcgacg ggcacggctg cagcgtcgcg gtgcatcaag cttgctatgg cattgttcaa      180

gtacccactg gaccgtggtt ttgcaggaaa tgtgaatctc aggagagagc agccagagtg      240

agatgtgaac tttgtcccca taaggatgga gctttaaaaa gaacagataa tgggggttgg      300

gcccatgtgg tttgtgccct gtatattcca gaggtacaat ttgccaatgt ttccacaatg      360

gaaccaattg ttttacagtc tgttccgcat gatcgttata ataagacttg ctacatttgt      420

gatgaacaag gaagagaaag caaagcagcc actggtgctt gcatgacatg taataaacat      480

ggatgtcgac aggctttcca tgtaacatgc gctcagtttg ccggactgct ttgtgaagaa      540

gaaggtaatg gtgccgataa tgtccaatac tgtggctact gtaaatacca ttttagtaag      600

ctgaaaaaga gcaaacgggg atctaatagg tcatatgatc aaagtttaag tgattcttcc      660

tctcactctc aggataaaca tcatgagaaa gagaaaaaaa aatataaaga gaaggacaaa      720

cacaaacaga aacacaagaa gcagccagaa ccatcacctg cattggttcc atccttgact      780

gttactacag aaaaaactta tacaagcact agcaacaact ctatatctgg atcattgaag      840

cgcttggaag atactactgc acgatttaca aatgcaaatt tccaggaagt ctctgcacac      900

acctctagtg gaaaagatgt ttcagagact agagggtcag agggcaaagg gaagaaatct      960

tcagctcaca gctcaggtca aaggggaaga aagcctggtg gtggaagaaa tccaggaaca     1020

actgtgtcag cagctagccc ttttcctcaa ggcagttttt caggaactcc aggcagtgta     1080

aagtcatctt ctggaagttc agtgcagtct ccccaggatt tcctgagctt tacagactca     1140

gatctgcgta atgacagtta ctctcactcc caacagtcat cagcaaccaa agatgtacat     1200

aaaggagagt ctggaagcca ggaagggggg gtaaatagtt ttagtacctt aattggcctc     1260

ccttcaacct cagctgttac ttcacagcct aaaagctttg aaaattcacc tggagatttg     1320

ggtaattcca gccttcctac agcaggatat aagcgggctc aaacttctgg catagaagaa     1380

gaaactgtaa aggaaaagaa aaggaaagga aataaacaaa gtaagcatgg gcctggcaga     1440

cccaaaggaa acaaaaatca agagaatgtt tctcatctct cagtttcttc tgcttcacca     1500

acatcatctg tagcatcagc tgcaggaagc ataacaagct ctagtctgca gaaatctcct     1560

acattgctca ggaatggaag tttacagagc ctcagtgttg gctcatctcc agttggttca     1620

gaaatttcca tgcagtatcg gcatgatgga gcttgcccaa caactacgtt ctcagagttg     1680

ctgaatgcaa tacacaacga cagaggtgac agttctacac taacaaagca agaacttaaa     1740

ttcataggta tttataacag caatgatgta gcagtatcgt ttccaaatgt agtatctggc     1800

tcgggatcta gtactcctgt ctccagctct cacttacctc agcagtcttc tgggcatttg     1860

caacaagtag gagcgctctc tccctcagct gtgtcatctg cagcccctgc tgttgctaca     1920

actcaggcaa atactctatc tggatcttct ctcagtcagg caccatctca tatgtatggc     1980

aatagatcaa attcatcaat ggcagctctt atagctcagt ctgaaaacaa tcaaacagat     2040

caagatcttg gagacaatag ccgcaaccta gttggcagag gaagctcacc ccgaggaagt     2100

ctctcgccac gatcccctgt aagcagctta cagattcgct atgatcaacc aggcaacagc     2160

agtttggaaa atctgcctcc agtagcagcc agcatagaac agcttttgga gaggcagtgg     2220

agtgaaggac agcaattttt actagaacag ggtactccta gtgacatttt aggaatgctg     2280

aagtcattac accaacttca agttgaaaac cgaagattag aggaacaaat taaaaacttg     2340

actgccaaaa aggaacggct tcagttattg aatgcacagc tttcagtgcc ttttccaaca     2400

ataacagcaa atcctagtcc gtctcatcaa atacacacat tttcagcaca gactgctcct     2460

actactgatt ccttgaacag cagtaagagc cctcatatag gaaacagctt tttacctgat     2520

aattctcttc ctgtattaaa tcaggactta acctccagtg gacaaagtac cagcagctca     2580

tcagctcttt ctaccccacc tcctgctggg cagagtccgg ctcaacaagg ctcaggagtg     2640

agtggagttc agcaggtcaa tggcgtgaca gtgggggcac tagctagtgg aatgcagcct     2700

gtaacttcca ccattcctgc cgtgtctgca gtgggtggaa taattggagc tttgccaggt     2760

aaccaactgg caattaatgg cattgtagga gctttaaatg gggttatgca gactcctgtc     2820

acaatgtccc agaaccctac ccctctcacc cacacaaccg taccacctaa tgcaacacat     2880

ccaatgccag ctacactgac taacagtgcc tcaggactag gattactttc tgaccagcaa     2940

cgacaaatac ttattcatca acagcagttt cagcagttgt taaattctca acagctcaca     3000

ccagtacaca ggcaccccca cttcacacag ctaccaccaa cccatttctc accatccatg     3060

gagataatgc aagtcagaaa gtag                                            3084


<210>  1348
<211>  606
<212>  DNA
<213>  homo sapiens

<400>  1348
atggcggcgc ggacagcgtt cggtgctgtg tgccggcgcc tctggcaggg attggggaat       60

ttttctgtaa acacttctaa gggcaataca gccaaaaatg gtggcttgct tctcagtacc      120

aatatgaagt gggtacagtt ttcaaaccta cacgttgatg ttccaaagga tttgaccaaa      180

cctgtggtaa caatctctga tgaaccagac atattatata agcgcctctc ggttttggtg      240

aaaggtcacg ataaggctgt attggacagt tatgaatatt ttgctgtgct tgctgctaaa      300

gaacttggta tctctattaa agtacatgaa cctccaagga aaatagagcg atttactctt      360

ctccaatcag tgcatattta caagaagcac agagttcagt atgaaatgag aacactttac      420

agatgtttag agttagaaca tctaactgga agcacagcag atgtctactt ggaatatatt      480

cagcgaaact tacctgaagg ggttgccatg gaagtaacaa agacacaatt agaacagtta      540

ccagaacaca tcaaggagcc aatctgggaa acactatcag aagaaaaaga agaaagcaag      600

tcataa                                                                 606


<210>  1349
<211>  2079
<212>  DNA
<213>  homo sapiens

<400>  1349
atgttctact tccgaggctg tggccgttgg gtcgcggttt ccttcaccaa gcagcaattt       60

ccgttggcac ggttgagcag tgacagcgcg gcgccccgga ctccgcactt cgacgtgata      120

gtcattggtg gaggacatgc cgggactgag gcagccaccg ccgccgctcg gtgcggctct      180

cggactctgc tcctcactca ccgcgtggac acgatcggtc agatgtcatg taatccttcc      240

tttggtggca tcggaaaggg acatttaatg agggaagtag atgccttgga tggcctgtgt      300

tctcgcatct gtgaccagtc tggtgtacat tataaagtat taaaccggcg taagggacca      360

gctgtgtggg gtctgagagc tcagattgat aggaaactct ataaacagaa catgcagaaa      420

gaaatcttga atacaccact gcttactgtt caggagggag ctgtagaaga tcttattctt      480

acagaaccag agcctgaaca cactgggaaa tgccgtgtca gtggggttgt tttggtggat      540

ggaagcacag tatatgcaga gagtgtgatt ctgactactg ggacatttct gagaggcatg      600

attgtaattg gattggagac gcatccagca ggacgtttag gggatcagcc ttctatagga      660

ttggctcaga cactggagaa gttagggttt gtggtgggaa ggttgaagac tgggactcca      720

ccccgaattg ccaaagagtc cattaatttc agtattctaa acaagcatat accggacaat      780

ccatccatac cattcagctt taccaatgag acagtatgga ttaagccaga agatcagctg      840

ccatgttact tgactcacac caaccctaga gtggatgaga ttgtccttaa gaaccttcac      900

cttaatagtc atgttaaaga aacgacaaga ggacctcgat actgtccctc cattgaatca      960

aaagttttgc gttttccaaa ccgtctacat caggtttggt tggaacctga aggaatggat     1020

tctgacctta tctacccaca ggggttatct atgacgctac cagctgagtt acaagagaaa     1080

atgatcacat gcatcagagg cttggagaaa gctaaagtga ttcagccagg ctacggtgtt     1140

cagtatgatt acttagatcc ccgtcagatc accccttcct tggagactca tttggttcaa     1200

cgactcttct ttgctggaca gatcaatggc accactggtt atgaggaagc tgcagctcaa     1260

ggtgtgatag ccggaatcaa cgccagtctt cgggtcagtc gcaagcctcc ctttgtggtt     1320

agccgaacag aaggttacat aggagtcttg attgatgacc tcactactct gggcaccagt     1380

gaaccatacc gcatgtttac cagccgagta gagttccgtt tgtcactgcg ccctgataat     1440

gctgacagcc ggctcacact gcgagggtat aaagacgctg gctgtgtgtc ccaacaacga     1500

tatgaaagag cttgttggat gaagtcttct ttagaagaag gcatttctgt gttgaaatct     1560

attgagtttt tgagctctaa atggaaaaaa ttaatcccag aggcttctat aagtactagt     1620

agaagtctgc ctgtcagagc tctcgatgtt ctgaagtatg aggaagttga catggattca     1680

ttagccaagg ctgttccaga gcccttgaag aagtatacta aatgtagaga gctggctgaa     1740

agactgaaaa tagaagccac ttatgaatca gtgttgttcc atcaactaca agaaataaag     1800

ggagttcagc aagatgaagc tctccaactg ccaaaagacc tagattattt gactatcagg     1860

gatgtgtctt tgtcccatga agttcgagag aaactacatt ttagtcgtcc acagacgatc     1920

ggggctgcta gtcgcatacc cggagtaaca cctgccgcca tcatcaatct gctgagattt     1980

gtgaagacca ctcaacgaag acagtcggct atgaatgaat catccaagac tgatcaatac     2040

ttatgtgatg cagacagact tcaagagaga gagttatag                            2079


<210>  1350
<211>  2097
<212>  DNA
<213>  homo sapiens

<400>  1350
atgaggaggt ttctgttact atatgctaca cagcagggac aggcaaaggc catcgcagaa       60

gaaatatgtg agcaagctgt ggtacatgga ttttctgcag atcttcactg tattagtgaa      120

tccgataagt atgacctaaa aaccgaaaca gctcctcttg ttgttgtggt ttctaccacg      180

ggcaccggag acccacccga cacagcccgc aagtttgtta aggaaataca gaaccaaaca      240

ctgccggttg atttctttgc tcacctgcgg tatgggttac tgggtctcgg tgattcagaa      300

tacacctact tttgcaatgg ggggaagata attgataaac gacttcaaga gcttggagcc      360

cggcatttct atgacactgg acatgcagat gactgtgtag gtttagaact tgtggttgag      420

ccgtggattg ctggactctg gccagccctc agaaagcatt ttaggtcaag cagaggacaa      480

gaggagataa gtggcgcact cccggtggca tcacctgcat cctcgaggac agaccttgtg      540

aagtcagagc tgctacacat tgaatctcaa gtcgagcttc tgagattcga tgattcagga      600

agaaaggatt ctgaggtttt gaagcaaaat gcagtgaaca gcaaccaatc caatgttgta      660

attgaagact ttgagtcctc acttacccgt tcggtacccc cactctcaca agcctctctg      720

aatattcctg gtttaccccc agaatattta caggtacatc tgcaggagtc tcttggccag      780

gaggaaagcc aagtatctgt gacttcagca gatccagttt ttcaagtgcc aatttcaaag      840

gcagttcaac ttactacgaa tgatgccata aaaaccactc tgctggtaga attggacatt      900

tcaaatacag acttttccta tcagcctgga gatgccttca gcgtgatctg ccctaacagt      960

gattctgagg tacaaagcct actccaaaga ctgcagcttg aagataaaag agagcactgc     1020

gtccttttga aaataaaggc agacacaaag aagaaaggag ctaccttacc ccagcatata     1080

cctgcgggat gttctctcca gttcattttt acctggtgtc ttgaaatccg agcaattcct     1140

aaaaaggcat ttttgcgagc ccttgtggac tataccagtg acagtgctga aaagcgcagg     1200

ctacaggagc tgtgcagtaa acaaggggca gccgattata gccgctttgt acgagatgcc     1260

tgtgcctgct tgttggatct cctcctcgct ttcccttctt gccagccacc actcagtctc     1320

ctgctcgaac atcttcctaa acttcaaccc agaccatatt cgtgtgcaag ctcaagttta     1380

tttcacccag gaaagctcca ttttgtcttc aacattgtgg aatttctgtc tactgccaca     1440

acagaggttc tgcggaaggg agtatgtaca ggctggctgg ccttgttggt tgcttcagtt     1500

cttcagccaa acatacatgc atcccatgaa gacagcggga aagccctggc tcctaagata     1560

tccatctctc ctcgaacaac aaattctttc cacttaccag atgacccctc aatccccatc     1620

ataatggtgg gtccaggaac cggcatagcc ccgtttattg ggttcctaca acatagagag     1680

aaactccaag aacaacaccc agatggaaat tttggagcaa tgtggttgtt ttttggctgc     1740

aggcataagg atagggatta tctattcaga aaagagctca gacatttcct taagcatggg     1800

atcttaactc atctaaaggt ttccttctca agagatgctc ctgttgggga ggaggaagcc     1860

ccagcaaagt atgtgcaaga caacatccag cttcatggcc agcaggtggc gagaatcctc     1920

ctccaggaga acggccatat ttatgtgtgt ggagatgcaa agaatatggc caaggatgta     1980

catgatgccc ttgtgcaaat aataagcaaa gaggttggag ttgaaaaact agaagcaatg     2040

aaaaccctgg ccactttaaa agaagaaaaa cgctaccttc aggatatttg gtcataa        2097


<210>  1351
<211>  666
<212>  DNA
<213>  homo sapiens

<400>  1351
atggcggcgg cggttcggat gaacatccag atgctgctgg aggcggccga ctatctggag       60

cggcgggaga gagaagctga acatggttat gcctccatgt taccatacaa taacaaggac      120

agagatgcct taaaacggag gaacaaatcc aaaaagaata acagcagtag cagatcaact      180

cacaatgaaa tggagaagaa tagacgggct catcttcgct tgtgcctgga gaagttgaag      240

gggctggtgc cacttggacc cgaatcaagt cgacacacta cgttgagttt attaacaaaa      300

gccaaattgc acataaagaa acttgaagat tgtgacagaa aagccgttca ccaaatcgac      360

cagcttcagc gagagcagcg acacctgaag aggcagctgg agaagctggg cattgagagg      420

atccggatgg acagcatcgg ctccaccgtc tcctcggagc gctccgactc cgacagggaa      480

gaaatcgacg ttgacgtgga gagcacggac tatctcacag gtgatctgga ctggagcagc      540

agcagtgtga gcgactctga cgagcggggc agcatgcaga gcctcggcag tgatgagggc      600

tattccagca ccagcatcaa gagaataaag ctgcaggaca gtcacaaggc gtgtcttggt      660

ctctaa                                                                 666


<210>  1352
<211>  5883
<212>  DNA
<213>  homo sapiens

<400>  1352
atggcacagc aagctgccga taagtatctc tatgtggata aaaacttcat caacaatccg       60

ctggcccagg ccgactgggc tgccaagaag ctggtatggg tgccttccga caagagtggc      120

tttgagccag ccagcctcaa ggaggaggtg ggcgaagagg ccatcgtgga gctggtggag      180

aatgggaaga aggtgaaggt gaacaaggat gacatccaga agatgaaccc gcccaagttc      240

tccaaggtgg aggacatggc agagctcacg tgcctcaacg aagcctcggt gctgcacaac      300

ctcaaggagc gttactactc agggctcatc tacacctatt caggcctgtt ctgtgtggtc      360

atcaatcctt acaagaacct gcccatctac tctgaagaga ttgtggaaat gtacaagggc      420

aagaagaggc acgagatgcc ccctcacatc tatgccatca cagacaccgc ctacaggagt      480

atgatgcaag accgagaaga tcaatccatc ttgtgcactg gtgaatctgg agctggcaag      540

acggagaaca ccaagaaggt catccagtat ctggcgtacg tggcgtcctc gcacaagagc      600

aagaaggacc agggcgagct ggagcggcag ctgctgcagg ccaaccccat cctggaggcc      660

ttcgggaacg ccaagaccgt gaagaatgac aactcctccc gcttcggcaa attcattcgc      720

atcaactttg atgtcaatgg ctacattgtt ggagccaaca ttgagactta tcttttggag      780

aaatctcgtg ctatccgcca agccaaggaa gaacggacct tccacatctt ctattatctc      840

ctgtctgggg ctggagagca cctgaagacc gatctcctgt tggagccgta caacaaatac      900

cgcttcctgt ccaatggaca cgtcaccatc cccgggcagc aggacaagga catgttccag      960

gagaccatgg aggccatgag gattatgggc atcccagaag aggagcaaat gggcctgctg     1020

cgggtcatct caggggttct tcagctcggc aacatcgtct tcaagaagga gcggaacact     1080

gaccaggcgt ccatgcccga caacacagct gcccaaaagg tgtcccatct cttgggtatc     1140

aatgtgaccg atttcaccag aggaatcctc accccgcgca tcaaggtggg acgggattac     1200

gtccagaagg cgcagactaa agagcaggct gactttgcca tcgaggcctt ggccaaggcg     1260

acctatgagc ggatgttccg ctggctggtg ctgcgcatca acaaggctct ggacaagacc     1320

aagaggcagg gcgcctcctt catcgggatc ctggacattg ccggcttcga gatctttgat     1380

ctgaactcgt ttgagcagct gtgcatcaat tacaccaatg agaagctgca gcagctcttc     1440

aaccacacca tgttcatcct ggagcaggag gagtaccagc gcgagggcat cgagtggaac     1500

ttcatcgact ttggcctcga cctgcagccc tgcatcgacc tcattgagaa gccagcaggc     1560

cccccgggca ttctggccct gctggacgag gagtgctggt tccccaaagc caccgacaag     1620

agcttcgtgg agaaggtgat gcaggagcag ggcacccacc ccaagttcca gaagcccaag     1680

cagctgaagg acaaagctga tttctgcatt atccactatg ccggcaaggt ggattacaaa     1740

gctgacgagt ggctgatgaa gaacatggat cccctgaatg acaacatcgc cacactgctc     1800

caccagtcct ctgacaagtt tgtctcggag ctgtggaagg atgtggaccg catcatcggc     1860

ctggaccagg tggccggcat gtcggagacc gcactgcccg gggccttcaa gacgcggaag     1920

ggcatgttcc gcactgtggg gcagctttac aaggagcagc tggccaagct gatggctacg     1980

ctgaggaaca cgaaccccaa ctttgtccgc tgcatcatcc ccaaccacga gaagaaggcc     2040

ggcaagctgg acccgcatct cgtgctggac cagctgcgct gcaacggtgt tctcgagggc     2100

atccgtatct gccgccaggg cttccccaac agggtggtct tccaggagtt tcggcagaga     2160

tatgagatcc tgactccaaa ctccattccc aagggtttca tggacgggaa gcaggcgtgc     2220

gtgctcatga taaaagccct ggagctcgac agcaatctgt accgcattgg ccagagcaaa     2280

gtcttcttcc gtgccggtgt gctggcccac ctggaggagg agcgagacct gaagatcacc     2340

gacgtcatca tagggttcca ggcctgctgc aggggctacc tggccaggaa agcatttgcc     2400

aagcggcagc agcagcttac cgccatgaag gtcctccagc ggaactgcgc tgcctacctg     2460

aagctgcgga actggcagtg gtggcggctc ttcaccaagg tcaagccgct gctgcaggtg     2520

agccggcagg aggaggagat gatggccaag gaggaggagc tggtgaaggt cagagagaag     2580

cagctggctg cggagaacag gctcacggag atggagacgc tgcagtctca gctcatggca     2640

gagaaattgc agctgcagga gcagctccag gcagaaaccg agctgtgtgc cgaggctgag     2700

gagctccggg cccgcctgac cgccaagaag caggaattag aagagatctg ccatgaccta     2760

gaggccaggg tggaggagga ggaggagcgc tgccagcacc tgcaggcgga gaagaagaag     2820

atgcagcaga acatccagga gcttgaggag cagctggagg aggaggagag cgcccggcag     2880

aagctgcagc tggagaaggt gaccaccgag gcgaagctga aaaagctgga ggaggagcag     2940

atcatcctgg aggaccagaa ctgcaagctg gccaaggaaa agaaactgct ggaagacaga     3000

atagctgagt tcaccaccaa cctcacagaa gaggaggaga aatctaagag cctcgccaag     3060

ctcaagaaca agcatgaggc aatgatcact gacttggaag agcgcctccg cagggaggag     3120

aagcagcgac aggagctgga gaagacccgc cggaagctgg agggagactc cacagacctc     3180

agcgaccaga tcgccgagct ccaggcccag atcgcggagc tcaagatgca gctggccaag     3240

aaagaggagg agctccaggc cgccctggcc agagtggaag aggaagctgc ccagaagaac     3300

atggccctca agaagatccg ggagctggaa tctcagatct ctgaactcca ggaagacctg     3360

gagtctgagc gtgcttccag gaataaagct gagaagcaga aacgggacct tggggaagag     3420

ctagaggctc tgaaaacaga gttggaggac acgctggatt ccacagctgc ccagcaggag     3480

ctcaggtcaa aacgtgagca ggaggtgaac atcctgaaga agaccctgga ggaggaggcc     3540

aagacccacg aggcccagat ccaggagatg aggcagaagc actcacaggc cgtggaggag     3600

ctggcggagc agctggagca gacgaagcgg gtgaaagcaa acctcgagaa ggcaaagcag     3660

actctggaga acgagcgggg ggagctggcc aacgaggtga aggtgctgct gcagggcaaa     3720

ggggactcgg agcacaagcg caagaaagtg gaggcgcagc tgcaggagct gcaggtcaag     3780

ttcaacgagg gagagcgcgt gcgcacagag ctggccgaca aggtcaccaa gctgcaggtg     3840

gagctggaca acgtgaccgg gcttctcagc cagtccgaca gcaagtccag caagctcacc     3900

aaggacttct ccgcgctgga gtcccagctg caggacactc aggagctgct gcaggaggag     3960

aaccggcaga agctgagcct gagcaccaag ctcaagcagg tggaggacga gaagaattcc     4020

ttccgggagc agctggagga ggaggaggag gccaagcaca acctggagaa gcagatcgcc     4080

accctccatg cccaggtggc cgacatgaaa aagaagatgg aggacagtgt ggggtgcctg     4140

gaaactgctg aggaggtgaa gaggaagctc cagaaggacc tggagggcct gagccagcgg     4200

cacgaggaga aggtggccgc ctacgacaag ctggagaaga ccaagacgcg gctgcagcag     4260

gagctggacg acctgctggt ggacctggac caccagcgcc agagcgcgtg caacctggag     4320

aagaagcaga agaagtttga ccagctcctg gcggaggaga agaccatctc tgccaagtat     4380

gcagaggagc gcgaccgggc tgaggcggag gcccgagaga aggagaccaa ggctctgtcg     4440

ctggcccggg ccctggagga agccatggag cagaaggcgg agctggagcg gctcaacaag     4500

cagttccgca cggagatgga ggaccttatg agctccaagg atgatgtggg caagagtgtc     4560

cacgagctgg agaagtccaa gcgggcccta gagcagcagg tggaggagat gaagacgcag     4620

ctggaagagc tggaggacga gctgcaggcc accgaagatg ccaagctgcg gttggaggtc     4680

aacctgcagg ccatgaaggc ccagttcgag cgggacctgc agggccggga cgagcagagc     4740

gaggagaaga agaagcagct ggtcagacag gtgcgggaga tggaggcaga gctggaggac     4800

gagaggaagc agcgctcgat ggcagtggcc gcccggaaga agctggagat ggacctgaag     4860

gacctggagg cgcacatcga ctcggccaac aagaaccggg acgaagccat caaacagctg     4920

cggaagctgc aggcccagat gaaggactgc atgcgcgagc tggatgacac ccgcgcctct     4980

cgtgaggaga tcctggccca ggccaaagag aacgagaaga agctgaagag catggaggcc     5040

gagatgatcc agttgcagga ggaactggca gccgcggagc gtgccaagcg ccaggcccag     5100

caggagcggg atgagctggc tgacgagatc gccaacagca gcggcaaagg agccctggcg     5160

ttagaggaga agcggcgtct ggaggcccgc atcgcccagc tggaggagga gctggaggag     5220

gagcagggca acacggagct gatcaacgac cggctgaaga aggccaacct gcagatcgac     5280

cagatcaaca ccgacctgaa cctggagcgc agccacgccc agaagaacga gaatgctcgg     5340

cagcagctgg aacgccagaa caaggagctt aaggtcaagc tgcaggagat ggagggcact     5400

gtcaagtcca agtacaaggc ctccatcacc gccctcgagg ccaagattgc acagctggag     5460

gagcagctgg acaacgagac caaggagcgc caggcagcct gcaaacaggt gcgtcggacc     5520

gagaagaagc tgaaggatgt gctgctgcag gtggatgacg agcggaggaa cgccgagcag     5580

tacaaggacc aggccgacaa ggcatctacc cgcctgaagc agctcaagcg gcagctggag     5640

gaggccgaag aggaggccca gcgggccaac gcctcccgcc ggaaactgca gcgcgagctg     5700

gaggacgcca ctgagacggc cgatgccatg aaccgcgaag tcagctccct aaagaacaag     5760

ctcaggcgcg gggacctgcc gtttgtcgtg ccccgccgaa tggcccggaa aggcgccggg     5820

gatggctccg acgaagaggt agatggcaaa gcggatgggg ctgaggccaa acctgccgaa     5880

taa                                                                   5883


<210>  1353
<211>  7647
<212>  DNA
<213>  homo sapiens

<400>  1353
atgaatataa atgatggagg aagacgacgc tttgaagata atgaacatac attacggata       60

tatcctgggg ctatttcaga agggacaatc tactgtccga ttcctgccag aaaaaactcc      120

acagctgctg aggtgattga gtctcttata aacaaacttc atcttgacaa aacaaaatgt      180

tatgttctag cagaggtaaa ggaatttggt ggagaagaat ggattctcaa tccaacagat      240

tgtccagttc agcgaatgat gctgtggccc cgaatggctc tggaaaatcg cttaagtgga      300

gaggactacc gcttccttct gagagagaaa aaccttgatg gatcaatcca ttatggtagc      360

ctgcagtcat ggctacgggt aacagaagaa cgtcgcagga tgatggaacg gggttttctt      420

ccacagcctc aacagaaaga ctttgatgat ttatgtagtt tacctgattt gaatgagaaa      480

actctcttag aaaacctacg aaatcgcttt aagcatgaaa aaatttatac ctatgttggc      540

agtattctaa tagttattaa cccattcaag tttcttccta tttataaccc caaatatgtc      600

aaaatgtatg ataaccacca actgggaaaa cttgagcccc acatttatgc tgtggctgat      660

gtagcttatc atgccatgct tcagcgcaaa aagaatcagt gcatcgtgat ttcaggagag      720

agtggttctg ggaagactca aagcacaaac tttcttattc accaccttac tgctctcagt      780

cagaaaggat ttgccagtgg agtagaacag attattcttg gagctggacc agtacttgag      840

gcctttggaa atgcaaagac agctcataat aacaattcaa gtcgttttgg gaagtttatt      900

caagtaaatt accaggaaac aggcactgta cttggtgcct atgttgaaaa atatctactg      960

gagaagtcca gactcgttta tcaggagcat aatgaacgga actatcatgt attctattac     1020

ctcctggcag gagcaagtga agatgagaga tcagcattcc atcttaagca accagaggaa     1080

tatcattatc tcaatcagat aacaaagaaa cccctcagac agagctggga tgattattgc     1140

tatgactctg agccggattg cttcacggtg gaaggagaag atttgagaca tgactttgag     1200

cgcctacaac ttgccatgga aatggtagga tttcttccca agacacgaag acagattttc     1260

tctcttctct cagccatact acatttgggt aatatctgtt acaaaaagaa gacataccgg     1320

gatgactcca ttgatatctg taatcctgaa gttctgccta ttgtctcaga attattagag     1380

gttaaagaag agatgctatt tgaagcatta gttacaagga agacggtgac agtgggagaa     1440

aagcttattt tgccatacaa gttggcagag gctgtgacag tgaggaactc catggctaag     1500

tctctgtata gtgccctgtt tgactggata gtttttcgaa ttaatcatgc acttctgaat     1560

agtaaagatt tagagcataa taccaagaca ttgtctattg gtgttcttga tatttttggg     1620

tttgaagatt atgaaaataa cagctttgaa cagttctgta ttaattttgc taatgaacgt     1680

ttacagcact actttaatca gcatatcttt aaattggaac aagaggaata tagaactgaa     1740

ggtatcagct ggcacaacat agattacatt gataatacct gctgcataaa tcttattagc     1800

aaaaaaccaa caggactgct tcatcttttg gatgaagaaa gcaactttcc acaggctaca     1860

aatcaaacat tgctagacaa gtttaagcat caacatgaag ataattctta catcgaattt     1920

ccagccgtga tggagcctgc tttcattata aaacattatg ctggaaaagt aaaatatggg     1980

gtaaaggatt tccgggaaaa aaatacagat catatgcgcc cagacattgt agctcttctg     2040

agaagcagca agaatgcatt tatctctggg atgattggaa ttgatcctgt agctgttttc     2100

cgatgggcaa ttctccgagc ttttttcaga gccatggttg ctttcaggga agctgggaaa     2160

agaaacattc acagaaaaac tggacatgat gatacagcgc catgtgcaat tttgaaaagt     2220

atggatagtt ttagctttct ccaacaccca gtccaccaga ggagcttaga gattctgcag     2280

agatgcaagg aagagaagta cagtataacc cggaaaaatc ccagaacacc tctttctgat     2340

ctccagggca tgaatgctct aaatgaaaaa aaccaacatg atacatttga tattgcctgg     2400

aatggcagaa ctgggattcg ccagagcaga ctatcaagtg gcacctcctt gcttgataaa     2460

gatggaatat ttgctaattc aactagcagc aaactcctgg agagagccca tggaattctc     2520

acgagaaaca aaaatttcaa atccaagcct gcccttccaa agcacttgct agaagtaaat     2580

tctttaaagc acctgacaag actgacacta caagatcgca ttaccaagtc tcttcttcat     2640

ttacacaaga agaaaaaacc tcccagcatc agtgcccagt ttcaggcatc attaagcaag     2700

ctaatggaaa cacttggtca agcagaacca tattttgtaa aatgcattcg ctctaatgct     2760

gaaaagctgc ccttaaggtt cagtgatgtc ttggtactta gacagcttcg atacaccggg     2820

atgctggaaa cagttcgaat tcgccaatca ggatacagct ccaaatattc tttccaggat     2880

tttgtgagcc acttccatgt acttcttccc cgaaatatta ttccatccaa atttaacatt     2940

caggatttct tcaggaaaat aaatcttaat ccagataatt atcaagttgg aaaaaccatg     3000

gtctttctaa aggagcagga acgacagcac ttacaagatc tgcttcacca agaggtgctc     3060

cgcagaatca tattgttgca gcgatggttc agggtcttgc tgtgtaggca gcatttcctc     3120

catctgagac aagcatctgt tattatccag agattctgga ggaattacct aaatcagaag     3180

caagtcagag atgcagctgt gcagaaggat gcttttgtta tggctagtgc agctgctctt     3240

ctccaagctt cctggcgtgc tcacttagag aggcagcggt acttggagtt acgggctgca     3300

gccatcgtta tccagcagaa atggagagat tactataggc gcaggcacat ggctgctatt     3360

tgcatacaag caagatggaa agcctacagg gaaagtaaaa ggtaccaaga acaaaggaaa     3420

aaaattatcc ttttgcaatc aacatgtaga ggattcagag caagacaaag atttaaagct     3480

ttaaaagaac aaaggctaag agaaacaaag ccagaagttg gattggtgaa tattaaggga     3540

tatggatctc tggaaattca gggttcagac ccttcaggat gggaggattg ttcttttgac     3600

aacagaataa aagccataga ggaatgtaaa tctgtaatag agagtaatcg aattagccgt     3660

gaaagttcag tggactgctt gaaggagtca ccaaacaagc agcaggagag agcccaaagc     3720

cagagtggtg tggacttgca ggaagatgtg cttgtaagag agagacccag atccttggag     3780

gatctccatc agaaaaaagt aggccgggct aagagagaaa gtaggagaat gagagaacta     3840

gagcaagcta tatttagctt agaattgctg aaagttcgtt ctcttggtgg tatttctcct     3900

tcagaggatc gcagatggtc tacagaattg gtgcctgaag gccttcagtc tccacggggt     3960

acacctgata gtgagagctc tcaaggaagc ttggaacttc tgagctatga ggaaagccaa     4020

aagagcaaac tagagtctgt catttcagat gaaggagact tgcagtttcc atcacctaag     4080

atatccagca gtccaaaatt tgattcacgg gacaatgccc tcagtgcctc aaatgagact     4140

agcagtgcag agcatttgaa ggatggaact atgaaggaaa tggtggtctg cagttctgag     4200

tctattacct gtaaaccaca gctgaaagac tccttcattt caaatagtct acctactttt     4260

ttttatatcc cccaacaaga cccactgaaa acaaattccc aactagacac aagtatccaa     4320

agaaacaaac tattggaaaa tgaagacaca gcgggggaag ctcttacttt ggatatcaac     4380

agggaaacta gaaggtatca ctgctcagga aaagatcaga ttgttccttc tttgaataca     4440

gagtcttcta atcctgtgct taagaagtta gaaaagctaa acactgagaa ggaagaaagg     4500

caaaaacagt tgcagcaaca gaatgaaaaa gagatgatgg aacagattcg ccagcaaaca     4560

gatattttag agaaggagcg caaagccttc aagacaattg aaaagccaag aattggagag     4620

tgtttggtgg caccatcttc ctatcagtca aagcaaagag tagagaggcc atcctctctc     4680

ctcagcttaa atacctcaaa taagggagaa cttaatgtac tggggtccct atcattaaaa     4740

gatgcagctc ttgcccaaaa agacagttcc tctgctcact tacccccaaa ggaccgacct     4800

gtcaccgtgt tctttgaaag aaaaggaagt ccatgccaat ctagtactgt caaggaatta     4860

tccaagacag acagaatggg cacccagctg aatgtagcct gtaaactctc aaataatcgc     4920

atttcaaaaa gagaacactt taggccaact cagtcttaca gccacaattc tgatgacctt     4980

tccagagagg gaaatgctag gcccattttc ttcactccaa aggacaatat gagtattccc     5040

cttgtcagca aagaagcctt aaacagtaaa aatcctcaac tccataaaga agatgaacca     5100

gcatggaaac ctgtgaagtt agctgggcca ggccaaagag agacatcaca gcgattttcg     5160

tcagttgatg aacaagcaaa acttcataag actatgtctc aaggagagat taccaagttg     5220

gcagtgagac agaaggcttc agattcagat ataagacctc agagagctaa gatgagattc     5280

tgggccaaag ggaaacaagg ggagaagaag actaccagag tgaaacctac tacccagtca     5340

gaggtttcgc cactctttgc aggcacagat gtgattccag ctcatcagtt tccagatgaa     5400

ttagctgcat atcacccaac acctcctttg agcccagaac tgcccggcag ttgccggaag     5460

gaattcaaag agaacaaaga accttctcca aaggctaagc gcaagcgaag tgtgaagatt     5520

agcaacgtgg ctttggattc tatgcattgg caaaatgact ctgtccagat catagcaagt     5580

gtcagtgatt taaaaagcat ggatgaattt cttctgaaaa aggtgaatga cctagataat     5640

gaagacagca agaaggatac actagtggat gttgtattta aaaaagccct gaaggaattt     5700

cggcagaata tcttcagctt ttattcatct gcattggcga tggatgatgg gaaaagcata     5760

cggtataaag acctctatgc actatttgaa cagattctgg aaaagacgat gaggcttgag     5820

cagcgtgatt cactgggtga atctccagtg agagtttggg tcaacacttt taaagtgttt     5880

ttagatgaat atatgaatga attcaagact tcagattgca cagccacaaa ggtgccaaaa     5940

acagaaagaa agaaaagaag gaaaaaggaa actgatttgg tggaagaaca caatggtcac     6000

atctttaaag ccacccaata tagcatccct acatactgtg aatactgttc ttctttgata     6060

tggataatgg accgagcctc tgtttgcaaa ttatgcaagt atgcttgcca taagaagtgc     6120

tgtctgaaaa ccacagccaa gtgctctaaa aagtatgatc cagagctgtc atctcgacaa     6180

tttggggttg aactgtcccg tttgaccagt gaagaccgaa ctgttccttt agtagtggaa     6240

aagctcataa actacattga aatgcatgga ctgtatacag aaggtattta tcgaaagtct     6300

ggttcgacta ataaaatcaa ggagcttcgg cagggtctag atacagatgc tgagagtgta     6360

aatctagatg actataacat acacgtcatt gcaagtgtat tcaaacaatg gcttcgagat     6420

ttgcccaatc ctctcatgac ctttgaactc tatgaggaat ttcttcgagc tatgggcctt     6480

caggagagga aggagacaat ccgtggtgta tactctgtga ttgatcaact ctcccgaact     6540

catctcaata cactggaacg cctcatcttt catctagtca ggattgctct gcaggaagac     6600

actaatcgaa tgtctgctaa tgctttggcc attgtgtttg cgccctgcat tctccgctgc     6660

cctgacacca ctgacccact acaaagtgta caggacatca gtaagactac cacttgtgtg     6720

gaactgattg ttgtggaaca aatgaataaa tacaaggctc gtctcaaaga tatcagtagc     6780

ttggaatttg ctgagaataa ggcaaagacc aggttgtcac tgattcgtag atcaatggga     6840

aaggggcgta ttcgtcgagg aaactatcca ggtccatcgt ctcctgttgt agttcggttg     6900

ccttctgtgt ctgatgtctc agaggagacc ttgactagtg aggcagccat ggagactgac     6960

atcacagaac agcagcaagc agctatgcag caggaggaga gagtactgac tgagcagatt     7020

gagaacctac agaaggagaa ggaggagcta acatttgaga tgcttgtact ggaaccccgt     7080

gcctctgatg atgaaaccct tgagtctgag gcctccattg ggactgctga tagctcagag     7140

aatttgaata tggagtctga atatgctatc tctgagaaat cagaaagaag cttagccctt     7200

agctccctga agacagctgg caagtctgaa ccttccagca agttgcgaaa gcaacttaaa     7260

aagcagcaag actctttaga tgtcgtggac tcttcggtct cctctttatg tctgtctaac     7320

acggcatcat ctcatgggac cagaaaacta tttcagattt attccaaatc tccattctac     7380

cgagctgcct caggtaatga ggccctggga atggaaggac cattgggcca gaccaaattc     7440

ctggaagaca agcctcagtt catcagcaga ggaaccttca acccggaaaa gggcaaacaa     7500

aaattaaaga atgtgaaaaa ctcacctcag aaaaccaaag agaccccaga ggggacagtc     7560

atgtctggcc gcagaaaaac tgtggaccca gactgcacct ccaaccaaca gctagcactc     7620

tttggaaata atgaatttat ggtctga                                         7647


<210>  1354
<211>  2373
<212>  DNA
<213>  homo sapiens

<400>  1354
atgtcgcggc ggcggcacag cgacgagaac gacggtgggc agcctcacaa aaggagaaag       60

acctctgatg caaatgaaac tgaagatcat ttggaatctt taatatgtaa agtaggagaa      120

aagagtgcct gctctttgga gagcaaccta gaaggcttgg ctggtgtttt ggaagctgat      180

cttcctaact acaagagcaa gatcttaagg cttctttgta cagttgcacg cctattacct      240

gagaagctga caatttatac aacattagtt ggactactga atgccaggaa ttacaatttt      300

ggtggagaat ttgtagaagc catgattcgt caacttaaag aatcattgaa agcaaacaat      360

tataatgaag ccgtgtattt ggtccgtttt ttatctgatc ttgtgaattg tcatgtgatt      420

gccgccccat caatggttgc tatgtttgaa aattttgtaa gcgtaactca ggaagaagat      480

gtacctcagg tgcgacgaga ttggtatgtg tatgcatttc tgtcatcttt gccctgggtt      540

ggaaaggagt tgtacgaaaa gaaagatgca gagatggacc gcatctttgc caacactgaa      600

agctatctta aaagacgcca aaagactcat gtacccatgt tacaggtatg gactgctgat      660

aaaccacatc cacaagaaga gtatttagat tgcctgtggg cccagattca gaaattgaaa      720

aaggatcgct ggcaggaacg gcacatccta agaccttatc ttgcctttga cagcatcctg      780

tgtgaagcac tgcagcacaa tctgcctcct tttacaccac ctcctcacac tgaagattca      840

gtgtacccaa tgccaagggt catcttcaga atgtttgatt acacagatga tcccgagggt      900

cctgtcatgc cagggagtca ttcagtggaa agatttgtaa tagaagagaa tcttcactgc      960

atcattaagt cccactggaa ggaaaggaag acttgtgctg cacagttagt gagctatcca     1020

gggaagaaca agatcccctt gaactaccac atagttgagg tgatctttgc agagctgttt     1080

caacttccag caccccctca cattgatgtg atgtacacaa cactcctcat tgaactgtgc     1140

aaacttcaac ctggctctct accccaagtt cttgcacagg caactgaaat gctatacatg     1200

cgtttggaca caatgaacac tacctgtgta gacaggttta ttaattggtt ttctcatcat     1260

ctaagtaact tccagttccg ttggagctgg gaagattggt cagattgtct tagtcaagat     1320

cctgaaagtc ccaaaccgaa gtttgtaaga gaagttctag aaaaatgtat gaggttgtct     1380

taccatcagc gtatattaga tattgttcct cctaccttct cagctctgtg tcctgcaaac     1440

ccaacctgca tttacaagta tggagatgaa agtagcaatt ctcttcctgg acattctgtt     1500

gccctctgtt tagctgttgc ctttaaaagt aaggcaacca atgatgaaat cttcagcatt     1560

ctgaaagatg taccaaatcc taaccaggat gatgacgacg atgaaggatt cagttttaac     1620

ccattgaaaa tagaagtctt tgtacagact ctgctacact tggcagccaa atcattcagc     1680

cactccttca gtgctcttgc aaagtttcat gaagtcttca aaaccctagc tgaaagtgat     1740

gaaggaaagt tacatgtgct aagagttatg tttgaggtct ggaggaacca tccacagatg     1800

attgctgtac tagtggataa gatgattcgt acacaaatag ttgattgtgc tgccgtagca     1860

aattggatct tctcttcaga actatctcgt gactttacca gattgtttgt ttgggaaatt     1920

ttgcactcta caattcgtaa gatgaacaaa catgtcctga agatccagaa agagctggaa     1980

gaagctaaag agaaacttgc taggcaacac aaacggcgaa gtgatgatga cgacagaagc     2040

agtgacagga aagacggggt tcttgaggaa caaatagaac gacttcagga aaaagtggaa     2100

tctgctcaga gtgaacaaaa gaatcttttc ctcgttatat ttcagcggtt tatcatgatc     2160

ttgaccgagc acctagtacg atgcgaaact gatgggacca gtgtattaac accatggtat     2220

aagaactgta tagagaggct gcagcagatc ttcctacagc atcaccaaat aatccagcag     2280

tacatggtga ccctggagaa ccttctcttc actgctgaat tagaccctca tatcttggcc     2340

gtgttccagc agttctgtgc cctgcaggcc taa                                  2373


<210>  1355
<211>  3777
<212>  DNA
<213>  homo sapiens

<400>  1355
atggagaagt atgttagact acagaagatt ggagaaggtt catttggaaa agccattctt       60

gttaaatcta cagaagatgg cagacagtat gttatcaagg aaattaacat ctcaagaatg      120

tccagtaaag aaagagaaga atcaaggaga gaagttgcag tattggcaaa catgaagcat      180

ccaaatattg tccagtatag agaatcattt gaagaaaatg gctctctcta catagtaatg      240

gattactgtg agggagggga tctgtttaag cgaataaatg ctcagaaagg cgttttgttt      300

caagaggatc agattttgga ctggtttgta cagatatgtt tggccctgaa acatgtacat      360

gatagaaaaa ttcttcatcg agacattaaa tctcagaaca tatttttaac taaagatgga      420

acagtacaac ttggagattt tggaattgct agagttctta atagtactgt agagctggct      480

cgaacttgca tagggacccc atactacttg tcacctgaaa tctgtgaaaa caaaccttac      540

aataataaaa gtgacatttg ggctctgggg tgtgtccttt atgagctgtg tacacttaaa      600

catgcttttg aagctggcag tatgaaaaac ctggtactga agataatatc tggatctttt      660

ccacctgtgt ctttgcatta ttcctatgat ctccgcagtt tggtgtctca gttatttaaa      720

agaaatccta gggatagacc atcagtcaac tccatattgg agaaaggttt tatagccaaa      780

cgcattgaaa agtttctctc tcctcagctt attgcagaag aattttgtct aaaaacattt      840

tcgaagtttg gatcacagcc tataccagct aaaagaccag cttcaggaca aaactcgatt      900

tctgttatgc ctgctcagaa aattacaaag cctgccgcta aatatggaat acctttagca      960

tataagaaat atggagataa aaaattacac gaaaagaaac cactgcaaaa acataaacag     1020

gcccatcaaa ctccagagaa gagagtgaat actggagaag aaaggaggaa aatatctgag     1080

gaagcagcaa gaaagagaag gctggaattt attgaaaaag aaaagaaaca aaaggatcag     1140

attattagtt taatgaaggc tgaacaaatg aaaaggcaag aaaaggaaag gttggaaaga     1200

ataaataggg ccagggaaca aggatggaga aatgtgctaa gtgctggtgg aagtggtgaa     1260

gtaaaggctc cttttctggg cagtggaggg actatagctc catcatcttt ttcttctcga     1320

ggacagtatg aacattacca tgccattttt gaccaaatgc agcaacaaag agcagaagat     1380

aatgaagcta aatggaaaag agaaatatat ggtcgaggtc ttccagaaag aggaattctg     1440

cctggagttc gtccaggatt tccttatggg gctgcaggtc atcaccattt tcctgatgct     1500

gatgatatta gaaaaacttt gaaaagattg aaggcggtgt ctaaacaagc caatgcaaac     1560

aggcaaaaag ggcagctagc tgtagaaaga gctaaacaag tagaagagtt cctgcagcga     1620

aaacgggaag ctatgcagaa taaagctcga gccgaaggac atatggttta tctggcaaga     1680

ctgaggcaaa taagactaca gaatttcaat gagcgccaac agattaaagc caaacttcgt     1740

ggtgaaaaga aagaagctaa tcattctgaa ggacaagaag gaagtgaaga ggctgacatg     1800

aggcgcaaaa aaatcgaatc actgaaggcc catgcaaatg cacgtgctgc tgtactaaaa     1860

gaacaactag aacgaaagag aaaggaggct tatgagagag aaaaaaaagt gtgggaagag     1920

catttggtgg ctaaaggagt taagagttct gatgtttctc cacctttggg acagcatgaa     1980

acaggtggct ctccatcaaa gcaacagatg agatctgtta tttctgtaac ttcagctttg     2040

aaagaagttg gcgtggacag tagtttaact gatacccggg aaacttcaga agagatgcaa     2100

aagaccaaca atgctatttc aagtaagcga gaaatacttc gtagattaaa tgaaaatctt     2160

aaagctcaag aagatgaaaa aggaaagcag aatctctctg atacttttga gataaatgtt     2220

catgaagatg ccaaagagca tgaaaaagaa aaatcagttt catctgatcg caagaagtgg     2280

gaggcaggag gtcaacttgt gattcctctg gatgagttaa cactagatac atccttctct     2340

acaactgaaa gacatacagt gggagaagtt attaaattag gtcctaatgg atctccaaga     2400

agagcctggg ggaaaagtcc gacagattct gttctaaaga tacttggaga agctgaacta     2460

caacttcaga cagaactatt agaaaataca actattagaa gtgagatttc tcccgaaggg     2520

gaaaagtaca aacccttaat tactggagaa aaaaaagtac aatgtatttc acatgaaata     2580

aacccatcag ctattgttga ttctcctgtt gagacaaaaa gtcccgagtt cagtgaggca     2640

tctccacaga tgtcattgaa actggaagga aatttagaag aacctgatga tttggaaaca     2700

gaaattctac aagagccaag tggaacaaac aaagatgaga gcttgccatg cactattact     2760

gatgtgtgga ttagtgagga aaaagaaaca aaggaaactc agtcggcaga taggatcacc     2820

attcaggaaa atgaagtttc tgaagatgga gtctcgagta ctgtggacca acttagtgac     2880

attcatatag agcctggaac caatgattct cagcactcta aatgtgatgt agataagtct     2940

gtgcaaccgg aaccattttt ccataaggtg gttcattctg aacacttgaa cttagtccct     3000

caagttcaat cagttcagtg ttcaccagaa gaatcctttg catttcgatc tcactcgcat     3060

ttaccaccaa aaaataaaaa caagaattcc ttgctgattg gactttcaac tggtctgttt     3120

gatgcaaaca acccaaagat gttaaggaca tgttcacttc cagatctctc aaagctgttc     3180

agaaccctta tggatgttcc caccgtagga gatgttcgtc aagacaatct tgaaatagat     3240

gaaattgaag atgaaaacat taaagaagga ccttctgatt ctgaagacat tgtgtttgaa     3300

gaaactgaca cagatttaca agagctgcag gcctcgatgg aacagttact tagggaacaa     3360

cctggtgaag aatacagtga agaagaagag tcagtcttga agaacagtga tgtggagcca     3420

actgcaaatg ggacagatgt ggcagatgaa gatgacaatc ccagcagtga aagtgccctg     3480

aacgaagaat ggcactcaga taacagtgat ggtgaaattg ctagtgaatg tgaatgcgat     3540

agtgtcttta accatttaga ggaactgaga cttcatctgg agcaggaaat gggctttgaa     3600

aaattctttg aggtttatga gaaaataaag gctattcatg aagatgaaga tgaaaatatt     3660

gaaatttgtt caaaaatagt tcaaaatatt ttgggaaatg aacatcagca tctttatgcc     3720

aagattcttc atttagtcat ggcagatgga gcctaccaag aagataatga tgaataa        3777


<210>  1356
<211>  3363
<212>  DNA
<213>  homo sapiens

<400>  1356
atggcggagg cgcctcctgt ctcaggtact tttaaattca atacagatgc tgctgaattc       60

attcctcagg agaaaaaaaa ttctggtcta aattgtggga ctcaaaggag actagactct      120

aataggattg gtagaagaaa ttacagttca ccacctccct gtcacctttc caggcaggtc      180

ccttatgatg aaatctctgc tgttcatcag catagttatc atccgtcagg aagcaaacct      240

aagagtcagc agacgtcttt ccagtcctct ccttgtaata aatcgcccaa gagccatggc      300

cttcagaatc aaccttggca gaaattgagg aatgagaagc accatatcag agtcaagaaa      360

gcacagagtc ttgctgagca gacctcagat acagctggat tagagagctc gaccagatca      420

gagagtggga cagacctcag agagcatagt ccttctgaga gtgagaagga agttgtgggt      480

gcagatccca ggggagcaaa acccaaaaaa gcaacacagt ttgtatacag ctatggtaga      540

ggaccaaaag tcaaggggaa actcaaatgt gaatggagta accgaacaac tccaaaaccg      600

gaggatgctg gacccgaaag taccaaacct gtgggggttt tccaccctga ctcttcagag      660

gcatcctcta gaaaaggagt attggatggg tatggagcca gacgaaatga gcagagaaga      720

tacccacaga aaaggcctcc ctgggaagtg gagggggcca ggccacgacc aggcagaaat      780

ccaccaaaac aggagggcca ccgacataca aacgcaggac acagaaacaa catgggcccc      840

attccaaagg atgacctcaa tgaaagacca gcaaaatcta cctgtgacag tgagaacttg      900

gcagtcatca acaagtcttc caggagggtt gaccaagaga aatgcactgt acggaggcag      960

gatcctcaag tagtatctcc tttctcccga ggcaaacaga accatgtgct aaagaatgtg     1020

gaaacgcaca caggttctct aattgaacaa ctaacaacag aaaaatacga gtgcatggtg     1080

tgctgtgaat tggttcgtgt cacggcccca gtgtggagtt gtcagagctg ttaccatgtg     1140

tttcatttga actgcataaa gaaatgggca aggtctccag catctcaagc agatggccag     1200

agtggttgga ggtgccctgc ctgtcagaat gtttctgcac atgttcctaa tacctacact     1260

tgtttctgtg gcaaggtaaa gaatcctgag tggagcagaa atgaaattcc acatagctgt     1320

ggtgaggttt gtagaaagaa acagcctggc caggactgcc cacattcctg taaccttctc     1380

tgccatccag gaccctgccc accctgccct gcctttatga caaaaacatg tgaatgtgga     1440

cgaaccaggc acacagttcg ctgtggtcag gctgtctcag tccactgttc taacccatgt     1500

gagaatattt tgaactgtgg tcagcaccag tgtgctgagc tgtgccatgg gggtcagtgc     1560

cagccttgcc agatcatttt gaaccaggta tgctattgcg gcagcacctc ccgagatgtg     1620

ttatgtggaa ccgatgtagg aaagtctgat ggatttgggg atttcagctg tttaaagata     1680

tgtggcaagg acttgaaatg cggtaaccat acatgttcgc aagtgtgcca ccctcagccc     1740

tgccagcaat gcccacggct cccccagctg gtgcgctgtt gcccctgtgg ccaaactcct     1800

ctcagccaat tgctagaact tggaagtagt agtcggaaaa catgcatgga ccctgtgcct     1860

tcatgtggaa aagtgtgcgg caagcctctg ccttgtggtt ccttagattt cattcatacc     1920

tgtgaaaagc tctgccatga aggagactgt ggaccatgct ctcgcacatc agttatttcc     1980

tgcagatgct ctttcagaac aaaggagctt ccatgtacca gtctcaaaag tgaagatgct     2040

acatttatgt gtgacaagcg gtgtaacaag aaacggttgt gtggacggca taaatgtaat     2100

gagatatgct gtgtggataa ggagcacaag tgtcctttga tttgtgggag gaaactccgt     2160

tgtggccttc ataggtgtga agaaccttgt catcgtggaa actgccagac atgctggcaa     2220

gccagttttg atgaattaac ctgccattgt ggtgcatcag tgatttaccc tccagttccc     2280

tgtggtacta ggccccctga atgtacccaa acctgcgcta gagtccatga gtgtgaccat     2340

ccagtatatc attcttgtca tagtgaggag aagtgtcccc cttgcacttt cctaactcag     2400

aagtggtgca tgggcaagca tgagtttcgg agcaacatcc cctgtcacct ggttgatatc     2460

tcttgcggat taccctgcag tgccacgcta ccatgtggga tgcacaaatg tcagagactc     2520

tgtcacaaag gggagtgtct tgtggatgag ccctgcaagc agccctgcac cacccccaga     2580

gctgactgtg gtcacccgtg tatggcaccc tgccatacca gctcaccctg ccctgtgact     2640

gcttgtaaag ctaaggtaga gctacagtgt gaatgtggac gaagaaaaga gatggtgatt     2700

tgctctgaag catctagtac ttatcaaaga atagctgcaa tctccatggc ctctaagata     2760

acagacatgc agcttggagg ttcagtggag atcagcaagt taattaccaa aaaggaagtt     2820

catcaagcca ggctggagtg tgatgaggag tgttcagcct tggaaaggaa aaagagatta     2880

gcagaggcat ttcatatcag tgaggattct gatcctttca atatacgttc ttcagggtca     2940

aaattcagtg atagtttgaa agaagatgcc aggaaggact taaagtttgt cagtgacgtt     3000

gagaaggaaa tggaaaccct cgtggaggcc gtgaataagg gaaagaatag taagaaaagc     3060

cacagcttcc ctcccatgaa cagagaccac cgccggatca tccatgactt ggcccaagtt     3120

tatggcctgg agagcgtgag ctatgacagt gaaccgaagc gcaatgtggt ggtcactgcc     3180

atcaggggga agtccgtttg tcctcctacc acgctgacag gtgtgcttga aagggaaatg     3240

caggcacggc ctccaccacc gattcctcat cacagacatc agtcagacaa gaatcctggg     3300

agcagtaatt tacagaaaat aaccaaggag ccaataattg actattttga cgtccaggac     3360

taa                                                                   3363


<210>  1357
<211>  936
<212>  DNA
<213>  homo sapiens

<400>  1357
atggcggcgc tgggggtgct ggagtccgac ctgccaagtg ccgtgacact tctgaaaaat       60

ctccaggagc aagtgatggc tgtaactgca caagtgaaat cactgacaca aaaagttcaa      120

gctggtgcct atcctacaga aaagggtctc agcttcttgg aagtgaaaga ccagctgctg      180

ctcatgtacc ttatggattt gacccacctc attctggaca aagcctcagg aggatctctt      240

cagggacatg atgcagtttt gagactggtg gagattcgca cggttttgga aaagcttcgt      300

cccttggacc aaaagctgaa gtatcaaatt gacaagctga tcaagactgc agtgacaggc      360

agccttagtg agaatgaccc acttcgtttt aagcctcatc ccagcaatat gatgagcaag      420

ttgagctctg aggatgagga ggaagatgaa gcagaagatg accagtctga ggcttcaggg      480

aagaaatctg tgaagggagt gtctaagaaa tatgttcctc cacgcttggt tccagtacat      540

tatgatgaaa cagaagctga gcgggagaag aagcgtctag aacgagccaa gagacgggca      600

ttgagcagct ctgtcattcg tgaacttaag gagcagtact cagatgctcc agaggaaatc      660

cgtgatgctc ggcatcccca tgttacccgc cagagtcagg aggaccaaca caggattaac      720

tatgaggaga gcatgatggt gcgtttgagc gtcagtaagc gagagaaagg acggcgaaaa      780

cgagcaaatg tcatgagctc acaacttcat tcccttacac acttcagtga catcagtgct      840

ttgacagggg gaactgttca tcttgatgag gatcagaatc ctattaagaa gcggaagaag      900

atacctcaga aaggtcggaa gaaaaaaggt cagtga                                936


<210>  1358
<211>  543
<212>  DNA
<213>  homo sapiens

<400>  1358
atgcggcctt tgactgaaga ggagacccgt gtcatgtttg agaagatagc gaaatacatt       60

ggggagaatc ttcaactgct ggtggaccgg cccgatggca cctactgttt ccgtctgcac      120

aacgaccggg tgtactatgt gagtgagaag attatgaagc tggccgccaa tatttccggg      180

gacaagctgg tgtcgctggg gacctgcttt ggaaaattca ctaaaaccca caagtttcgg      240

ttgcacgtca cagctctgga ttaccttgca ccttatgcca agtataaagt ttggataaag      300

cctggtgcag agcagtcctt cctgtatggg aaccatgtgt tgaaatctgg tctgggtcga      360

atcactgaaa atacttctca gtaccagggc gtggtggtgt actccatggc agacatccct      420

ttgggttttg gggtggcagc caaatctaca caagactgca gaaaagtaga ccccatggcg      480

attgtggtat ttcatcaagc agacattggg gaatatgtgc ggcatgaaga gacgttgact      540

taa                                                                    543


<210>  1359
<211>  2067
<212>  DNA
<213>  homo sapiens

<400>  1359
atgcaggtct ccagcctcaa tgaggtgaag atttacagcc tcagctgcgg caagtccctt       60

cctgagtggc tttctgatag gaagaagaga gcgctacaga agaaagatgt agatgtccgt      120

aggagaattg aacttattca ggactttgaa atgcctactg tgtgtaccac tattaaggtg      180

tcaaaagatg gacagtacat tttagcaact ggaacatata aacctcgggt tcgatgttat      240

gacacctatc aattatcctt gaagtttgaa aggtgtttag attcagaagt tgtcaccttt      300

gaaattttgt ctgatgacta ctcaaagatt gtcttcttac ataatgatag atacattgaa      360

tttcattcgc aatcaggttt ttactacaaa accagaatac caaagtttgg gagagatttc      420

tcttaccact atccatcctg tgacttgtac tttgttggtg caagttctga agtttatagg      480

ttaaacttag aacaaggacg atacctgaat cctctacaaa ctgatgctgc ggagaataat      540

gtttgtgaca taaattcagt gcatggcttg tttgccacag gaaccataga gggtagagtg      600

gagtgctggg acccaagaac tcgaaacaga gttggcctgt tagactgcgc cttaaacagt      660

gtcacagcag attcagagat aaacagttta ccaacaatct ctgctttgaa atttaatggt      720

gccttgacca tggcagttgg aacaaccaca gggcaggttt tattatatga ccttcgatct      780

gataagccat tgctagttaa agatcaccag tatgggctgc ccattaagtc cgttcatttc      840

caggattcat tagatctgat tttgtctgct gactctcgaa ttgtcaagat gtggaataag      900

aactccggaa aaatatttac ttccttggag ccagagcatg accttaatga tgtttgtctc      960

taccccaact caggcatgct tctgacggcc aatgaaaccc ccaagatggg catctattac     1020

attccagttt tgggtcctgc tcctcggtgg tgttccttct tagacaactt gaccgaagaa     1080

ttagaagaga atccagaaag cacagtctat gatgattata aatttgtcac caagaaagac     1140

cttgaaaatt tagggctcac ccacctcatt ggatctcctt tcctccgggc atatatgcat     1200

gggtttttca tggatataag actctatcac aaggtgaaac tgatggtaaa tccatttgct     1260

tatgaagaat ataggaaaga taaaatacga cagaaaatag aagaaacacg tgcacagaga     1320

gtccagttaa agaaattgcc aaaagttaac aaagagctgg cacttaaatt aattgaggaa     1380

gaagaggaga agcagaaatc tacatggaaa aagaaagtta agagtcttcc taatattctc     1440

accgatgatc gatttaaagt tatgtttgag aaccctgact tccaagtaga tgaagagagt     1500

gaagaattta ggcttctgaa tccacttgtt tcaaaaatta gtgaaaaaag gaagaagaaa     1560

ctaagactct tagagcaaca agaacttcgt gaaaaagaag aggaggaaga gccggaagga     1620

aaaccaagtg atgcagaaag ttcggagagt tcagatgatg aaaaagcctg ggttgaagag     1680

gtcaggaagc aacgcagact cctccagcag gaggaaaaag tgaagcggca ggaacgactc     1740

aaggaggacc agcagacagt cctaaagccc cagttttatg agatcaaagc aggagaagaa     1800

tttagaagct tcaaagattc tgccacaaag cagaaactga tgaacaaaac ccttgaagat     1860

cgtttgaaaa ttgaagcaaa aaatgggaca ttgagtgtat ccgacaccac cgttggcagc     1920

aaacaattga cattcacgtt aaagaggtct gaacagcaga agaagcaaca ggaggctgag     1980

aaactgcatc gacaagaaag gaaaagactc cgtcgttcgg ccggacacct gaagtcaaga     2040

cacaaaagag gacggtcgtt tcattga                                         2067


<210>  1360
<211>  3504
<212>  DNA
<213>  homo sapiens

<400>  1360
atgaaagtga acagagaaac gaagcgcctt tatgtgggtg gccttagcca ggacatttct       60

gaggcagacc tacaaaatca gttcagcaga tttggagaag tttcggatgt ggagatcatc      120

acacggaaag atgaccaagg aaacccacag aaagtttttg catatatcaa catcagtgta      180

gcagaagcgg acctgaaaaa atgtatgtct gttttaaata aaacaaaatg gaaaggtgga      240

acattacaaa ttcaactagc aaaagaaagc tttctgcaca gattggccca agagagagaa      300

gcagcaaaag ctaagaaaga agaatcaaca acaggtaacg ccaacttgtt agaaaagaca      360

ggaggagtgg atttccatat gaaagctgtg ccagggacag aagtgccagg gcataagaat      420

tgggttgtga gcaaatttgg aagagtctta cctgttcttc accttaaaaa tcaacataaa      480

cgtaaaatca tcaaatatga tccctcaaaa tactgccaca acctgaagaa gataggggag      540

gatttctcaa acaccattcc tatatccagc ctgacttggg aattagaagg agggaatgac      600

cctatgagta agaaacggcg aggagagttc tctgactttc atggccctcc caagaagata      660

ataaaagtgc agaaggatga gagttccact gggtctctgg ccatgagtac aaggcccagg      720

agggtaatag agagaccacc cttaacacag caacaggctg cacaaaaaag aacttgtgat      780

tccattactc cttctaaatc atctcctgta cctgtttctg atactcagaa acttaaaaat      840

ctacctttta agacttctgg cttggaaact gccaagaaga gaaacagcat ttctgatgat      900

gatactgatt ctgaagatga attgagaatg atgattgcga aagaggaaaa cttacagaga      960

actacacaac cctcaataaa tgaatctgaa agtgatcctt ttgaagttgt aagggatgat     1020

ttcaaatcag gcgttcacaa actgcattct ttaataggtt taggtatcaa aaatcgtgtc     1080

tcttgccatg atagtgatga tgatattatg agaaatgatc gtgagtatga ctcaggagat     1140

acagatgaaa ttattgcgat gaaaaaaaat gttgctaagg tcaaaaacag tacagaattt     1200

tcacaaatgg aaaaatctac gaagaaaact tctttcaaaa atagagaaaa ctgtgagctt     1260

tctgatcact gtattaaact acaaaaaaga aaaagcaatg tagagtcagc cctcagtcat     1320

ggattaaagt ctcttaatcg taaatctccc tctcactcca gtagcagtga agatgctgat     1380

tctgcatcag aattagctga ctctgaagga ggtgaggagt ataatgccat gatgaaaaac     1440

tgccttcgtg tgaatctcac tttagctgat ttggaacaat tggctggcag tgatctgaag     1500

gttccaaatg aagatactaa gagtgatgga ccagaaacca ccacccaatg caagtttgac     1560

agaggctcca agagccccaa gactcccact ggcctccgca gaggccgaca gtgtattcgt     1620

cctgcggaga ttgtggcttc cctgttagaa ggagaggaga acacctgtgg caaacagaaa     1680

ccaaaggaaa acaatttaaa gccaaaattt caggctttca agggagtagg ctgtctatat     1740

gaaaaggagt caatgaaaaa atccttgaaa gacagtgttg cctctaacaa taaagatcag     1800

aattccatga aacatgagga tcccagtatc atatccatgg aagatgggtc cccatatgtt     1860

aatggctcat taggtgaagt gactccatgc caacatgcaa agaaggcgaa tggcccaaac     1920

tatattcagc ctcaaaaaag acagaccact tttgaaagcc aggatcgcaa ggcagtgtcc     1980

cctagcagtt ctgaaaagag aagtaagaat cctatttcta ggccattaga aggtaagaag     2040

tccttaagtc ttagtgcaaa gactcacaac ataggctttg acaaagacag ctgccatagt     2100

accacaaaga cagaagcttc acaggaagag cggtctgatt caagcggcct cacatctctc     2160

aagaaatcac caaaggtctc atccaaggac actcgggaaa tcaaaactga tttctcactt     2220

tctattagta attcgtcaga tgtgagtgct aaagataagc atgctgaaga caatgagaag     2280

cgtttggcag ccttggaagc gaggcaaaaa gcaaaagaag tgcagaagaa gctggtgcat     2340

aatgctctgg caaatttgga tggtcatcca gaggataagc caacgcacat catcttcggt     2400

tctgacagtg aatgtgaaac agaggagaca tcgactcagg agcagagcca tccaggagag     2460

gaatgggtga aagagtctat gggtaaaaca tcagggaagc tgtttgatag cagtgatgat     2520

gacgaatctg attctgaaga tgacagtaat aggttcaaaa ttaaacctca gtttgagggc     2580

agagctggac agaagctcat ggatttacag tcgcactttg gcaccgatga cagattccgc     2640

atggactctc gatttctaga aactgacagt gaagaggaac aggaagaggt aaatgaaaag     2700

aaaactgctg aggaagaaga gcttgctgaa gaaaaaaaga aagccctgaa tgttgtacaa     2760

agtgttttgc aaatcaactt aagcaattct acaaacagag gatcagtagc tgctaagaaa     2820

tttaaggaca tcatacatta tgatccaacg aagcaagacc atgccactta cgaaagaaaa     2880

agagatgata agccaaaaga aagtaaagca aaacgaaaaa agaaaaggga ggaagctgag     2940

aaactacctg aggtgtctaa agaaatgtat tataatattg ctatggatct gaaagaaata     3000

ttccaaacta caaaatatac cagtgaaaag gaagagggca caccctggaa tgaggactgt     3060

ggtaaagaga aacctgagga aatccaggac cctgcagctc tgaccagtga cgctgagcag     3120

cccagcgggt tcacgttctc tttttttgat tcagacacta aagacataaa ggaagagacc     3180

tacagagttg aaacagtgaa acctggaaag attgtctggc aggaagaccc tcgtttacaa     3240

gacagcagtt cagaagagga agatgttact gaagaaacag atcacagaaa ctccagtcct     3300

ggagaagcat cattacttga gaaagagacc actagatttt tctttttctc taagaatgat     3360

gaacgacttc aaggttctga cttattctgg agaggagtag gaagtaatat gagcaggaac     3420

tcttgggagg ccagaacaac caacctgcgt atggattgtc gaaagaaaca taaagacgca     3480

aaaaggaaaa tgaaaccaaa ataa                                            3504


<210>  1361
<211>  7416
<212>  DNA
<213>  homo sapiens

<400>  1361
atgcccgccc tgcgccccgc tctgctgtgg gcgctgctgg cgctctggct gtgctgcgcg       60

gcccccgcgc atgcattgca gtgtcgagat ggctatgaac cctgtgtaaa tgaaggaatg      120

tgtgttacct accacaatgg cacaggatac tgcaaatgtc cagaaggctt cttgggggaa      180

tattgtcaac atcgagaccc ctgtgagaag aaccgctgcc agaatggtgg gacttgtgtg      240

gcccaggcca tgctggggaa agccacgtgc cgatgtgcct cagggtttac aggagaggac      300

tgccagtact caacatctca tccatgcttt gtgtctcgac cctgcctgaa tggcggcaca      360

tgccatatgc tcagccggga tacctatgag tgcacctgtc aagtcgggtt tacaggtaag      420

gagtgccaat ggacggatgc ctgcctgtct catccctgtg caaatggaag tacctgtacc      480

actgtggcca accagttctc ctgcaaatgc ctcacaggct tcacagggca gaaatgtgag      540

actgatgtca atgagtgtga cattccagga cactgccagc atggtggcac ctgcctcaac      600

ctgcctggtt cctaccagtg ccagtgccct cagggcttca caggccagta ctgtgacagc      660

ctgtatgtgc cctgtgcacc ctcaccttgt gtcaatggag gcacctgtcg gcagactggt      720

gacttcactt ttgagtgcaa ctgccttcca ggttttgaag ggagcacctg tgagaggaat      780

attgatgact gccctaacca caggtgtcag aatggagggg tttgtgtgga tggggtcaac      840

acttacaact gccgctgtcc cccacaatgg acaggacagt tctgcacaga ggatgtggat      900

gaatgcctgc tgcagcccaa tgcctgtcaa aatgggggca cctgtgccaa ccgcaatgga      960

ggctatggct gtgtatgtgt caacggctgg agtggagatg actgcagtga gaacattgat     1020

gattgtgcct tcgcctcctg tactccaggc tccacctgca tcgaccgtgt ggcctccttc     1080

tcttgcatgt gcccagaggg gaaggcaggt ctcctgtgtc atctggatga tgcatgcatc     1140

agcaatcctt gccacaaggg ggcactgtgt gacaccaacc ccctaaatgg gcaatatatt     1200

tgcacctgcc cacaaggcta caaaggggct gactgcacag aagatgtgga tgaatgtgcc     1260

atggccaata gcaatccttg tgagcatgca ggaaaatgtg tgaacacgga tggcgccttc     1320

cactgtgagt gtctgaaggg ttatgcagga cctcgttgtg agatggacat caatgagtgc     1380

cattcagacc cctgccagaa tgatgctacc tgtctggata agattggagg cttcacatgt     1440

ctgtgcatgc caggtttcaa aggtgtgcat tgtgaattag aaataaatga atgtcagagc     1500

aacccttgtg tgaacaatgg gcagtgtgtg gataaagtca atcgtttcca gtgcctgtgt     1560

cctcctggtt tcactgggcc agtttgccag attgatattg atgactgttc cagtactccg     1620

tgtctgaatg gggcaaagtg tatcgatcac ccgaatggct atgaatgcca gtgtgccaca     1680

ggtttcactg gtgtgttgtg tgaggagaac attgacaact gtgaccccga tccttgccac     1740

catggtcagt gtcaggatgg tattgattcc tacacctgca tctgcaatcc cgggtacatg     1800

ggcgccatct gcagtgacca gattgatgaa tgttacagca gcccttgcct gaacgatggt     1860

cgctgcattg acctggtcaa tggctaccag tgcaactgcc agccaggcac gtcaggggtt     1920

aattgtgaaa ttaattttga tgactgtgca agtaaccctt gtatccatgg aatctgtatg     1980

gatggcatta atcgctacag ttgtgtctgc tcaccaggat tcacagggca gagatgtaac     2040

attgacattg atgagtgtgc ctccaatccc tgtcgcaagg gtgcaacatg tatcaacggt     2100

gtgaatggtt tccgctgtat atgccccgag ggaccccatc accccagctg ctactcacag     2160

gtgaacgaat gcctgagcaa tccctgcatc catggaaact gtactggagg tctcagtgga     2220

tataagtgtc tctgtgatgc aggctgggtt ggcatcaact gtgaagtgga caaaaatgaa     2280

tgcctttcga atccatgcca gaatggagga acttgtgaca atctggtgaa tggatacagg     2340

tgtacttgca agaagggctt taaaggctat aactgccagg tgaatattga tgaatgtgcc     2400

tcaaatccat gcctgaacca aggaacctgc tttgatgaca taagtggcta cacttgccac     2460

tgtgtgctgc catacacagg caagaattgt cagacagtat tggctccctg ttccccaaac     2520

ccttgtgaga atgctgctgt ttgcaaagag tcaccaaatt ttgagagtta tacttgcttg     2580

tgtgctcctg gctggcaagg tcagcggtgt accattgaca ttgacgagtg tatctccaag     2640

ccctgcatga accatggtct ctgccataac acccagggca gctacatgtg tgaatgtcca     2700

ccaggcttca gtggtatgga ctgtgaggag gacattgatg actgccttgc caatccttgc     2760

cagaatggag gttcctgtat ggatggagtg aatactttct cctgcctctg ccttccgggt     2820

ttcactgggg ataagtgcca gacagacatg aatgagtgtc tgagtgaacc ctgtaagaat     2880

ggagggacct gctctgacta cgtcaacagt tacacttgca agtgccaggc aggatttgat     2940

ggagtccatt gtgagaacaa catcaatgag tgcactgaga gctcctgttt caatggtggc     3000

acatgtgttg atgggattaa ctccttctct tgcttgtgcc ctgtgggttt cactggatcc     3060

ttctgcctcc atgagatcaa tgaatgcagc tctcatccat gcctgaatga gggaacgtgt     3120

gttgatggcc tgggtaccta ccgctgcagc tgccccctgg gctacactgg gaaaaactgt     3180

cagaccctgg tgaatctctg cagtcggtct ccatgtaaaa acaaaggtac ttgcgttcag     3240

aaaaaagcag agtcccagtg cctatgtcca tctggatggg ctggtgccta ttgtgacgtg     3300

cccaatgtct cttgtgacat agcagcctcc aggagaggtg tgcttgttga acacttgtgc     3360

cagcactcag gtgtctgcat caatgctggc aacacgcatt actgtcagtg ccccctgggc     3420

tatactggga gctactgtga ggagcaactc gatgagtgtg cgtccaaccc ctgccagcac     3480

ggggcaacat gcagtgactt cattggtgga tacagatgcg agtgtgtccc aggctatcag     3540

ggtgtcaact gtgagtatga agtggatgag tgccagaatc agccctgcca gaatggaggc     3600

acctgtattg accttgtgaa ccatttcaag tgctcttgcc caccaggcac tcggggccta     3660

ctctgtgaag agaacattga tgactgtgcc cggggtcccc attgccttaa tggtggtcag     3720

tgcatggata ggattggagg ctacagttgt cgctgcttgc ctggctttgc tggggagcgt     3780

tgtgagggag acatcaacga gtgcctctcc aacccctgca gctctgaggg cagcctggac     3840

tgtatacagc tcaccaatga ctacctgtgt gtttgccgta gtgcctttac tggccggcac     3900

tgtgaaacct tcgtcgatgt gtgtccccag atgccctgcc tgaatggagg gacttgtgct     3960

gtggccagta acatgcctga tggtttcatt tgccgttgtc ccccgggatt ttccggggca     4020

aggtgccaga gcagctgtgg acaagtgaaa tgtaggaagg gggagcagtg tgtgcacacc     4080

gcctctggac cccgctgctt ctgccccagt ccccgggact gcgagtcagg ctgtgccagt     4140

agcccctgcc agcacggggg cagctgccac cctcagcgcc agcctcctta ttactcctgc     4200

cagtgtgccc caccattctc gggtagccgc tgtgaactct acacggcacc ccccagcacc     4260

cctcctgcca cctgtctgag ccagtattgt gccgacaaag ctcgggatgg cgtctgtgat     4320

gaggcctgca acagccatgc ctgccagtgg gatgggggtg actgttctct caccatggag     4380

aacccctggg ccaactgctc ctccccactt ccctgctggg attatatcaa caaccagtgt     4440

gatgagctgt gcaacacggt cgagtgcctg tttgacaact ttgaatgcca ggggaacagc     4500

aagacatgca agtatgacaa atactgtgca gaccacttca aagacaacca ctgtgaccag     4560

gggtgcaaca gtgaggagtg tggttgggat gggctggact gtgctgctga ccaacctgag     4620

aacctggcag aaggtaccct ggttattgtg gtattgatgc cacctgaaca actgctccag     4680

gatgctcgca gcttcttgcg ggcactgggt accctgctcc acaccaacct gcgcattaag     4740

cgggactccc agggggaact catggtgtac ccctattatg gtgagaagtc agctgctatg     4800

aagaaacaga ggatgacacg cagatccctt cctggtgaac aagaacagga ggtggctggc     4860

tctaaagtct ttctggaaat tgacaaccgc cagtgtgttc aagactcaga ccactgcttc     4920

aagaacacgg atgcagcagc agctctcctg gcctctcacg ccatacaggg gaccctgtca     4980

taccctcttg tgtctgtcgt cagtgaatcc ctgactccag aacgcactca gctcctctat     5040

ctccttgctg ttgctgttgt catcattctg tttattattc tgctgggggt aatcatggca     5100

aaacgaaagc gtaagcatgg ctctctctgg ctgcctgaag gtttcactct tcgccgagat     5160

gcaagcaatc acaagcgtcg tgagccagtg ggacaggatg ctgtggggct gaaaaatctc     5220

tcagtgcaag tctcagaagc taacctaatt ggtactggaa caagtgaaca ctgggtcgat     5280

gatgaagggc cccagccaaa gaaagtaaag gctgaagatg aggccttact ctcagaagaa     5340

gatgacccca ttgatcgacg gccatggaca cagcagcacc ttgaagctgc agacatccgt     5400

aggacaccat cgctggctct cacccctcct caggcagagc aggaggtgga tgtgttagat     5460

gtgaatgtcc gtggcccaga tggctgcacc ccattgatgt tggcttctct ccgaggaggc     5520

agctcagatt tgagtgatga agatgaagat gcagaggact cttctgctaa catcatcaca     5580

gacttggtct accagggtgc cagcctccag gcccagacag accggactgg tgagatggcc     5640

ctgcaccttg cagcccgcta ctcacgggct gatgctgcca agcgtctcct ggatgcaggt     5700

gcagatgcca atgcccagga caacatgggc cgctgtccac tccatgctgc agtggcagct     5760

gatgcccaag gtgtcttcca gattctgatt cgcaaccgag taactgatct agatgccagg     5820

atgaatgatg gtactacacc cctgatcctg gctgcccgcc tggctgtgga gggaatggtg     5880

gcagaactga tcaactgcca agcggatgtg aatgcagtgg atgaccatgg aaaatctgct     5940

cttcactggg cagctgctgt caataatgtg gaggcaactc ttttgttgtt gaaaaatggg     6000

gccaaccgag acatgcagga caacaaggaa gagacacctc tgtttcttgc tgcccgggag     6060

gggagctatg aagcagccaa gatcctgtta gaccattttg ccaatcgaga catcacagac     6120

catatggatc gtcttccccg ggatgtggct cgggatcgca tgcaccatga cattgtgcgc     6180

cttctggatg aatacaatgt gaccccaagc cctccaggca ccgtgttgac ttctgctctc     6240

tcacctgtca tctgtgggcc caacagatct ttcctcagcc tgaagcacac cccaatgggc     6300

aagaagtcta gacggcccag tgccaagagt accatgccta ctagcctccc taaccttgcc     6360

aaggaggcaa aggatgccaa gggtagtagg aggaagaagt ctctgagtga gaaggtccaa     6420

ctgtctgaga gttcagtaac tttatcccct gttgattccc tagaatctcc tcacacgtat     6480

gtttccgaca ccacatcctc tccaatgatt acatcccctg ggatcttaca ggcctcaccc     6540

aaccctatgt tggccactgc cgcccctcct gccccagtcc atgcccagca tgcactatct     6600

ttttctaacc ttcatgaaat gcagcctttg gcacatgggg ccagcactgt gcttccctca     6660

gtgagccagt tgctatccca ccaccacatt gtgtctccag gcagtggcag tgctggaagc     6720

ttgagtaggc tccatccagt cccagtccca gcagattgga tgaaccgcat ggaggtgaat     6780

gagacccagt acaatgagat gtttggtatg gtcctggctc cagctgaggg cacccatcct     6840

ggcatagctc cccagagcag gccacctgaa gggaagcaca taaccacccc tcgggagccc     6900

ttgcccccca ttgtgacttt ccagctcatc cctaaaggca gtattgccca accagcgggg     6960

gctccccagc ctcagtccac ctgccctcca gctgttgcgg gccccctgcc caccatgtac     7020

cagattccag aaatggcccg tttgcccagt gtggctttcc ccactgccat gatgccccag     7080

caggacgggc aggtagctca gaccattctc ccagcctatc atcctttccc agcctctgtg     7140

ggcaagtacc ccacaccccc ttcacagcac agttatgctt cctcaaatgc tgctgagcga     7200

acacccagtc acagtggtca cctccagggt gagcatccct acctgacacc atccccagag     7260

tctcctgacc agtggtcaag ttcatcaccc cactctgctt ctgactggtc agatgtgacc     7320

accagcccta cccctggggg tgctggagga ggtcagcggg gacctgggac acacatgtct     7380

gagccaccac acaacaacat gcaggtttat gcgtga                               7416


<210>  1362
<211>  1812
<212>  DNA
<213>  homo sapiens

<400>  1362
atggcaacca tagaagaaat tgcacatcaa attattgaac aacagatggg agagattgtt       60

acagagcagc aaactgggca gaaaatccag attgtgacag cacttgatca taatacccaa      120

ggcaagcagt tcattctgac aaatcacgac ggctctactc caagcaaagt cattctggcc      180

aggcaagatt ccactccggg aaaagttttc cttacaactc cagatgcagc aggtgtcaac      240

cagttatttt ttaccactcc tgatctgtct gcacaacacc tgcagctcct aacagataat      300

tctccagacc aaggaccaaa taaggttttt gatctttgcg tagtatgtgg agacaaagca      360

tcaggacgtc attatggagc agtaacttgt gaaggctgca aaggattttt taaaagaagc      420

atccgaaaaa atttagtata ttcatgtcga ggatcaaagg attgtattat taataagcac      480

caccgaaacc gctgtcaata ctgcaggtta cagagatgta ttgcgtttgg aatgaagcaa      540

gactctgtcc aatgtgaaag aaaacccatt gaagtatcac gagaaaaatc ttccaactgt      600

gccgcttcaa cagaaaaaat ctatatccga aaggaccttc gtagcccatt aactgcaact      660

ccaacttttg taacagatag tgaaagtaca aggtcaacag gactgttaga ttcaggaatg      720

ttcatgaata ttcatccatc tggagtaaaa actgagtcag ctgtgctgat gacatcagat      780

aaggctgaat catgtcaggg agatttaagt acattggcca atgtggttac atcattagcg      840

aatcttggaa aaactaaaga tctttctcaa aatagtaatg aaatgtctat gattgaaagc      900

ttaagcaatg atgatacctc tttgtgtgaa tttcaagaaa tgcagaccaa cggtgatgtt      960

tcaagggcat ttgacactct tgcaaaagca ttgaatcctg gagagagcac agcctgccag     1020

agctcagtag cgggcatgga aggaagtgta cacctaatca ctggagattc aagcataaat     1080

tacaccgaaa aagaggggcc acttctcagc gattcacatg tagctttcag gctcaccatg     1140

ccttctccta tgcctgagta cctgaatgtg cactacattg gggagtctgc ctccagactg     1200

ctgttcttat caatgcactg ggcactttcg attccttctt tccaggctct agggcaagaa     1260

aacagcatat cactggtgaa agcttactgg aatgaacttt ttactcttgg tcttgcccag     1320

tgctggcaag tgatgaatgt agcaactata ttagcaacat ttgtcaattg tcttcacaat     1380

agtcttcaac aagataaaat gtcaacagaa agaagaaaat tattgatgga gcacatcttc     1440

aaactacagg agttttgtaa cagcatggtt aaactctgca ttgatggata cgaatatgcc     1500

tacctgaagg caatagtact cttcagtcca gatcatccaa gcctagaaaa catggaacag     1560

atagagaaat ttcaggaaaa ggcttatgtg gaattccaag attatataac caaaacatat     1620

ccagatgaca cctacaggtt atccagacta ctactcagat tgccagcttt aagactgatg     1680

aatgctacca tcactgaaga attgtttttc aaaggtctca ttggcaatat acgaattgac     1740

agtgttatcc cacatatttt gaaaatggag cctgcagatt ataactctca aataattggt     1800

cacagcattt ga                                                         1812


<210>  1363
<211>  1257
<212>  DNA
<213>  homo sapiens

<400>  1363
atgttttctc ctgatcaaga aaatcatcca tctaaagcac cagtaaaata tggtgaactc       60

attgtcttag ggtataatgg gtctctccca aatggcgata gaggaaggag gaaaagtagg      120

tttgctttgt ttaaaagacc taaggcaaat ggggtgaagc ccagcactgt gcatattgct      180

tgtactcctc aggctgcaaa ggcaataagc aacaaagacc agcatagcat atcatatact      240

ttatctcggg cccagactgt ggtggttgaa tatactcatg acagcaacac cgatatgttt      300

cagattggcc ggtcgactga aagccccatt gattttgtag taactgacac ggttcctgga      360

agtcaaagta attctgatac acagtcagta caaagcacta tatcaagatt tgcctgcaga      420

atcatatgtg aacggaatcc tccctttaca gcacggattt atgctgcagg atttgactca      480

tcaaaaaaca tctttcttgg ggagaaggct gccaaatgga agacatcaga tggacagatg      540

gatggcttga ccactaatgg tgttcttgtg atgcatccac gcaatgggtt cacagaagac      600

tccaagcctg gaatatggag agaaatatcg gtgtgtggaa atgtatttag cctacgtgaa      660

accagatcgg ctcagcagag aggaaaaatg gtggaaattg aaaccaatca gttacaagat      720

ggctcgttaa ttgacctctg tggtgcaaca ttgttatggc gtactgcaga aggcctttcc      780

cacactccta ccgtgaagca tttagaagct ttaagacagg aaatcaatgc agcacgacct      840

cagtgccctg tagggttcaa cacactagca tttcctagta tgaagaggaa agacgttgta      900

gatgaaaaac aaccatgggt atatctaaac tgcggccatg tacatggcta tcataactgg      960

ggaaacaaag aagaacgtga tggaaaagat cgtgaatgtc ctatgtgtag gtctgttggt     1020

ccctatgttc ctctgtggct tggatgtgaa gctggatttt atgtggacgc cggccctcca     1080

acccatgcgt ttagcccgtg tgggcatgtg tgttcagaaa agacaactgc ctattggtcc     1140

cagatcccac ttcctcatgg tactcatact tttcatgcag cctgtccctt ttgtgcacat     1200

cagttggctg gtgaacaagg ctacatcaga cttatttttc aaggacctct agactaa        1257


<210>  1364
<211>  3852
<212>  DNA
<213>  homo sapiens

<400>  1364
atgtggggca gcgatcgcct ggcgggtgct gggggaggcg gggcggcagt gactgtggcc       60

ttcaccaacg ctcgcgactg cttcctccac ctgccgcggc gtctcgtggc ccagctgcat      120

ctgctgcaga atcaagctat agaagtggtc tggagtcacc agcctgcatt cttgagctgg      180

gtggaaggca ggcattttag tgatcaaggt gaaaatgtgg ctgaaattaa cagacaagtt      240

ggtcaaaaac ttggactctc aaatggggga caggtatttc tcaagccatg ttcccatgtg      300

gtatcttgtc aacaagttga ggtggaaccc ctctcagcag atgattggga gatactggag      360

ctgcatgctg tttcccttga acaacatctt ctagatcaaa ttcgaatagt ttttccaaaa      420

gccatttttc ctgtttgggt tgatcaacaa acgtacatat ttatccaaat tgttgcacta      480

ataccagctg cctcttatgg aaggctggaa actgacacca aactccttat tcagccaaag      540

acacgccgag ccaaagagaa tacattttca aaagctgatg ctgaatataa aaaacttcat      600

agttatggaa gagaccagaa aggaatgatg aaagaacttc aaaccaagca acttcagtca      660

aatactgtgg gaatcactga atctaatgaa aacgagtcag agattccagt tgactcatca      720

tcagtagcaa gtttatggac tatgatagga agcatttttt cctttcaatc tgagaagaaa      780

caagagacat cttggggttt aactgaaatc aatgcattca aaaatatgca gtcaaaggtt      840

gttcctctag acaatatttt cagagtatgc aaatctcaac ctcctagtat atataacgcg      900

tcagcaacct ctgtttttca taaacactgt gccattcatg tatttccatg ggaccaggaa      960

tattttgatg tagagcccag ctttactgtg acatatggaa agctagttaa gctactttct     1020

ccaaagcaac agcaaagtaa aacaaaacaa aatgtgttat cacctgaaaa agagaagcag     1080

atgtcagagc cactagatca aaaaaaaatt aggtcagatc ataatgaaga agatgagaag     1140

gcctgtgtgc tacaagtagt ctggaatgga cttgaagaat tgaacaatgc catcaaatat     1200

accaaaaatg tagaagttct ccatcttggg aaagtctgga ttccagatga cctgaggaag     1260

agactaaata tagaaatgca tgccgtagtc aggataactc cagtggaagt tacccctaaa     1320

attccaagat ctctaaagtt acaacctaga gagaatttac ctaaagacat aagtgaagaa     1380

gacataaaaa ctgtatttta ttcatggcta cagcagtcta ctaccaccat gcttcctttg     1440

gtaatatcag aggaagaatt tattaagctg gaaactaaag atggactgaa ggaattttct     1500

ctgagtatag ttcattcttg ggaaaaagaa aaagataaaa atatttttct gttgagtccc     1560

aatttgctgc agaagactac aatacaagtc cttctagatc ctatggtaaa agaagaaaac     1620

agtgaggaaa ttgactttat tcttcctttt ttaaagctga gctctttggg aggagtgaat     1680

tccttaggcg tatcctcctt ggagcacatc actcacagcc tcctgggacg ccctttgtct     1740

cggcagctga tgtctcttgt tgcaggactt aggaatggag ctcttttact cacaggagga     1800

aagggaagtg gaaaatcaac tttagccaaa gcaatctgta aagaagcatt tgacaaactg     1860

gatgcccatg tggagagagt tgactgtaaa gctttacgag gaaaaaggct tgaaaacata     1920

caaaaaaccc tagaggtggc tttctcagag gcagtgtgga tgcagccatc tgttgtcctg     1980

ctggatgacc ttgacctcat tgctggactg cctgctgtcc cggaacatga gcacagtcct     2040

gatgcggtgc agagccagcg gcttgctcat gctttgaatg atatgataaa agagtttatc     2100

tccatgggaa gtttggttgc actgattgcc acaagtcagt ctcagcaatc tctacatcct     2160

ttacttgttt ctgctcaagg agttcacata tttcagtgcg tccaacacat tcagcctcct     2220

aatcaggaac aaagatgtga aattctgtgt aatgtaataa aaaataaatt ggactgtgat     2280

ataaacaagt tcaccgatct tgacctgcag catgtagcta aagaaactgg cgggtttgtg     2340

gctagagatt ttacagtact tgtggatcga gccatacatt ctcgactctc tcgtcagagt     2400

atatccacca gagaaaaatt agttttaaca acattggact tccaaaaggc tctccgcgga     2460

tttcttcctg cgtctttgcg aagtgtcaac ctgcataaac ctagagacct gggttgggac     2520

aagattggtg ggttacatga agttaggcag atactcatgg atactatcca gttacctgcc     2580

aagtatccag aattatttgc aaacttgccc atacgacaaa gaacaggaat actgttgtat     2640

ggtccgcctg gaacaggaaa aaccttacta gctggggtaa ttgcacgaga gagtagaatg     2700

aattttataa gtgtcaaggg gccagagtta ctcagcaaat acattggagc aagtgaacaa     2760

gctgttcggg atatttttat tagagcacag gctgcaaagc cctgcattct tttctttgat     2820

gaatttgaat ccattgctcc tcggcggggt catgataata caggagttac agaccgagta     2880

gttaaccagt tgctgactca gttggatgga gtagaaggct tacagggtgt ttatgtattg     2940

gctgctacta gtcgccctga cttgattgac cctgccctgc ttaggcctgg tcgactagat     3000

aaatgtgtat actgtcctcc tcctgatcag gtgtcacgtc ttgaaatttt aaatgtcctc     3060

agtgactctc tacctctggc agatgatgtt gaccttcagc atgtagcatc agtaactgac     3120

tcctttactg gagctgatct gaaagcttta ctttacaatg cccaattgga ggccttacat     3180

ggaatgctgc tctcgagtgg actccaggat ggaagttcca gctctgatag tgacctaagt     3240

ctgtcttcaa tggtctttct taaccatagc agtggctctg acgattcagc tggagatgga     3300

gaatgtggct tagatcagtc ccttgtttct ttagagatgt ccgagatcct tccagatgaa     3360

tcaaaattca atatgtaccg gctctacttt ggaagctctt atgaatcaga acttggaaat     3420

ggaacctctt ctgatttgag ctcacaatgt ctctctgcac caagctccat gactcaggat     3480

ttgcctggag ttcctgggaa agaccagttg ttttcacagc ctccagtgtt aaggacagct     3540

tcacaagagg gttgccaaga acttacacaa gaacaaagag atcaactgag ggcagatatc     3600

agtattatca aaggcagata ccggagccaa agtggagagg acgaatccat gaaccaacca     3660

ggaccaatca aaaccagact ggctattagt cagtcacatt taatgactgc acttggtcac     3720

acaagaccat ccattagtga agatgactgg aagaattttg ctgagctata tgaaagcttt     3780

caaaatccaa agaggagaaa aaatcaaagt ggaacaatgt ttcgacctgg acagaaagta     3840

actttagcat aa                                                         3852


<210>  1365
<211>  2988
<212>  DNA
<213>  homo sapiens

<400>  1365
atggcggaag cggaatttaa ggaccatagt acagctatgg atactgaacc aaacccggga       60

acatcttctg tgtcaacaac aaccagcagt accaccacca ccaccatcac cacttcctcc      120

tctcgaatgc agcagccaca gatctctgtc tacagtggtt cagaccgaca tgctgtacag      180

gtaattcaac aggcattgca tcggcccccc agctcagctg ctcagtacct tcagcaaatg      240

tatgcagccc aacaacagca cttgatgctg catactgcag ctcttcagca gcagcattta      300

agcagctccc agcttcagag ccttgctgct gttcaggcaa gtttgtccag tggaagacca      360

tctacatctc ccacaggaag tgtcacacag cagtcaagta tgtcccaaac gtctatcaac      420

ctctccactt ctcctacacc tgcacagtta ataagccgtt cccaggcttc cagttctacc      480

agcggcagta ttacccaaca gactatgtta ctagggagta cttcccctac cctaacggca      540

agccaagctc aaatgtatct ccgagctcaa atgctgattt tcacacccgc taccactgtg      600

gctgctgtac agtctgacat tcctgttgtc tcgtcgtcat cgtcatcttc ctgtcagtct      660

gcagctactc aggttcagaa tttaacatta cgcagccaga agttgggtgt attatctagc      720

tcacagaatg gtccaccaaa aagcactagt caaactcagt cattgacaat ttgtcataac      780

aaaacaacag tgaccagttc taaaatcagc caacgagatc cttctccaga aagtaataag      840

aaaggagaga gcccaagcct ggaatcacga agcacagctg tcacccggac atcaagtatt      900

caccagttaa tagcaccagc ttcatattct ccaattcagc ctcattctct aataaaacat      960

cagcagattc ctcttcattc accaccttcc aaagtttccc atcatcagct gatattacaa     1020

cagcagcaac agcaaattca gccaatcaca cttcagaatt caactcaaga cccaccccca     1080

tcccagcact gtataccact ccagaaccat ggccttcctc cagctcccag taatgcccag     1140

tcacagcatt gttcaccgat tcagagtcat ccctctcctt taacagtgtc tcctaatcag     1200

tcacagtcag cacagcagtc tgtagtggtg tctcctccac cacctcattc accaagtcag     1260

tctcctacta taattattca tccacaagca cttattcagc cacaccctct tgtgtcatca     1320

gctctccagc cagggccaaa tttgcagcag tccactgcta atcaggtgca agctacagca     1380

cagttgaatc ttccatccca tcttccactt ccagcttccc ctgttgtaca cattggccca     1440

gttcagcagt ctgccttggt atccccaggc cagcagattg tctctccatc acaccagcaa     1500

tattcatccc tgcagtcctc tccaatccca attgcaagtc ctccacagat gtcgacatct     1560

cctccagctc agattccacc actgcccttg cagtctatgc agtctttaca agtgcagcct     1620

gaaattctgt cccagggcca ggttttggtg cagaatgctt tggtgtcaga agaggaactt     1680

ccagctgcag aagctttggt ccagttgcca tttcagactc ttcctcctcc acagactgtt     1740

gcggtaaacc tacaagtgca accaccagca cctgttgatc caccagtggt ttatcaggta     1800

gaagatgtgt gtgaagaaga aatgccagaa gagtcagatg aatgtgtccg gatggataga     1860

accccaccac cacccacttt gtctccagca gctataacag tggggagagg agaagatttg     1920

acttctgaac atcctttgtt agagcaagtg gaattacctg ctgtggcatc agtcagtgct     1980

tcagtaatta aatctccatc agatccctca catgtttctg ttccaccacc tccattgtta     2040

cttccagctg ccaccacaag gagtaacagt acatctatgc acagtagcat tcccagtata     2100

gagaacaaac ctccacaggc tattgttaaa ccacagatcc taacccatgt tattgaaggc     2160

tttgtgattc aggagggatt ggagccattt cctgtgagtc gttcctcttt gctaatagaa     2220

cagcctgtga aaaaacggcc tcttttggat aatcaggtga taaattcagt gtgtgttcag     2280

ccagagctac agaataatac aaaacatgcg gataattcat ctgacacaga gatggaagac     2340

atgattgctg aagagacatt agaagaaatg gacagtgagt tgctcaagtg tgaattctgt     2400

gggaaaatgg gatatgctaa tgaatttttg cggtcaaaac gattctgcac tatgtcatgt     2460

gccaaaaggt acaatgttag ctgttctaaa aaatttgcac ttagtcgttg gaatcgtaag     2520

cctgataatc aaagtcttgg gcatcgtggc cgtcgtccaa gtggccctga tggggcagcg     2580

agagaacata tccttaggca gcttccaatt acttatccat ctgcagaaga agacttggct     2640

tctcatgaag attctgtgcc atctgctatg acaactcgtc tgcgcaggca gagcgagcgg     2700

gaaagagaac gtgagcttcg ggatgtgaga attcggaaaa tgcctgagaa cagtgacttg     2760

ctaccagttg cacaaacaga gccatctata tggacagttg atgatgtctg ggccttcatc     2820

cattctttgc ctggctgcca ggatatcgca gatgaattca gagcacagga gattgatgga     2880

caggcccttc tcttgctgaa agaagaccat ctcatgagtg caatgaatat caagctaggc     2940

ccagccctga agatctgtgc acgcatcaac tctctgaagg aatcttaa                  2988


<210>  1366
<211>  3006
<212>  DNA
<213>  homo sapiens

<400>  1366
atgccaacag agaagaagat cagcagtgca agtgattgta ttaattcaat ggttgagggt       60

tcagaactca aaaaggttcg ctccaactct agaatttatc ataggtactt tttactggat      120

gctgacatgc agagcctaag gtgggagcca tctaagaagg attctgagaa agccaagatt      180

gacattaaat ccatcaagga agtgagaaca ggaaaaaaca cagacatatt ccgcagcaat      240

ggcatttctg accagatatc tgaagattgt gcgttttccg tcatatatgg agagaattat      300

gagtcactgg atttggttgc caactccgca gatgttgcaa acatctgggt tacaggactg      360

cggtacctaa tttcttatgg aaaacataca cttgatatgt tagaaagtag ccaagataac      420

atgaggactt cttgggtttc acaaatgttt agtgaaattg atgtagataa ccttggacat      480

ataactctgt gtaatgctgt gcaatgtatc agaaacctca atcctggttt aaaaacgagc      540

aaaattgagc ttaagttcaa agaattgcat aaatcaaagg acaaagctgg taccgaggtc      600

acaaaggaag aatttattga ggtttttcat gagctttgta ctagacctga aatttatttc      660

cttttagttc agttttcaag caataaagaa ttccttgata ccaaggacct tatgatgttt      720

cttgaggcag aacagggtgt ggcacatata aatgaggaaa taagccttga aattattcac      780

aaatatgaac catccaaaga gggtcaggaa aagggctggc tctccataga cgggttcact      840

aattacctta tgtcacctga ctgttatata ttcgatccag aacataagaa ggtctgtcag      900

gatatgaagc aacctctgtc tcattacttt ataaactcat ctcataatac atacttaata      960

gaggatcagt tccgaggtcc ctccgacatc acaggatata ttcgagctct taaaatgggt     1020

tgccggagtg ttgaattaga tgtatgggat gggccggaca atgaacctgt aatttacaca     1080

ggccacacca tgacctctca gatagttttc cgcagtgtca ttgatattat taacaagtat     1140

gcattctttg cttcagagta tcctcttatc ttgtgtttag aaaaccactg ttccattaaa     1200

caacagaagg taatggttca gcacatgaag aaacttttag gagacaagct ctatacaaca     1260

tcacccaatg ttgaggaatc ttatctacca tccccagatg tcctgaaagg gaaaatacta     1320

attaaagcaa agaagctgtc ctcaaattgc tctggggtag aaggagatgt tactgacgaa     1380

gatgaaggag cagaaatgtc tcagaggatg ggaaaagaga acatggagca acccaataat     1440

gtgcctgtga agcgatttca gctttgtaaa gaactgtctg aactggtcag catctgcaaa     1500

tcagttcagt tcaaagaatt tcaggtgtcg tttcaggttc agaagtactg ggaagtctgt     1560

tcctttaatg aagtgcttgc cagcaagtac gccaatgaaa atccagggga ctttgtaaat     1620

tacaacaaac gttttcttgc tagggttttt cccagtccaa tgagaattga ttccagtaac     1680

atgaatcctc aagatttttg gaaatgtggt tgccaaattg tagccatgaa ctttcagaca     1740

ccaggactga tgatggacct gaatattggc tggtttaggc agaacggaaa ctgtggctat     1800

gtcctccggc cagccatcat gagggaggag gtctccttct tcagcgccaa tacaaaagac     1860

tctgtcccag gggtctcacc tcaacttctt cacattaaaa tcatcagtgg gcagaacttt     1920

cccaagccca aaggatcagg tgccaaaggt gatgtggtag atccttatgt ctatgttgaa     1980

atccatggaa tccctgctga ttgtgcagaa caaaggacaa aaacagtgca ccagaatgga     2040

gacgctccca tttttgatga aagctttgaa tttcaaatca acctgcctga actggccatg     2100

gtgcgctttg tagtgctgga tgatgactac attggggatg aattcatcgg ccagtacaca     2160

attccctttg aatgtttaca gacgggctac cgccatgtcc ccctgcagtc cttaactgga     2220

gaggtccttg cacatgcttc tttatttgtc cacgtggcta ttactaaccg aagaggagga     2280

ggaaagcctc ataaaagggg cctttctgtg agaaaaggga agaaatccag ggaatatgca     2340

tctttgagaa cactgtggat taaaaccgtg gatgaggtat tcaagaatgc ccagccccct     2400

atacgggatg ccacagatct gagagaaaac atgcagaatg cggtggtgtc attcaaggag     2460

ctgtgtggcc tctcctctgt ggccaatctc atgcagtgca tgttggcggt gtctccccgc     2520

tttctggggc ccgataacac acccctagtg gtcctaaatc tcagcgagca gtaccccaca     2580

atggagctgc agggaattgt gccggaggtt ctgaagaaga tcgtaacaac ttatgacatg     2640

atgattcagt ccctcaaggc gttgattgaa aatgcagatg ctgtatatga aaagatcgta     2700

cattgtcaga aggcagccat ggaattccat gaacacttgc acagcatagg caccaaggaa     2760

ggtttgaagg aaagaaaact acaaaaagca gtggagagct ttacctggaa tattaccatc     2820

ttaaagggac aagcagatct tttgaaatat gctaagaatg agacattgga gaacctgaaa     2880

caaatccatt ttgctgctgt ttcatgtgga ctgaataaac caggcaccga aaatgctgat     2940

gtccagaagc cacgccggag cttggaagtc atacccgaaa aagcaaacga tgaaactgga     3000

gaatga                                                                3006


<210>  1367
<211>  5913
<212>  DNA
<213>  homo sapiens

<400>  1367
atgcacgggg gtggcccccc ctcgggggac agcgcatgcc cgctgcgcac catcaagaga       60

gtccagttcg gagtcctgag tccggatgaa ctgaagcgaa tgtctgtgac ggagggtggc      120

atcaaatacc cagagacgac tgagggaggc cgccccaagc ttggggggct gatggacccg      180

aggcaggggg tgattgagcg gactggccgc tgccaaacat gtgcaggaaa catgacagag      240

tgtcctggcc actttggcca cattgaactg gccaagcctg tgtttcacgt gggcttcctg      300

gtgaagacaa tgaaagtttt gcgctgtgtc tgcttcttct gctccaaact gcttgtggac      360

tctaacaacc caaagatcaa ggatatcctg gctaagtcca agggacagcc caagaagcgg      420

ctcacacatg tctacgacct ttgcaagggc aaaaacatat gcgagggtgg ggaggagatg      480

gacaacaagt tcggtgtgga acaacctgag ggtgacgagg atctgaccaa agaaaagggc      540

catggtggct gtgggcggta ccagcccagg atccggcgtt ctggcctaga gctgtatgcg      600

gaatggaagc acgttaatga ggactctcag gagaagaaga tcctgctgag tccagagcga      660

gtgcatgaga tcttcaaacg catctcagat gaggagtgtt ttgtgctggg catggagccc      720

cgctatgcac ggccagagtg gatgattgtc acagtgctgc ctgtgccccc gctctccgtg      780

cggcctgctg ttgtgatgca gggctctgcc cgtaaccagg atgacctgac tcacaaactg      840

gctgacatcg tgaagatcaa caatcagctg cggcgcaatg agcagaacgg cgcagcggcc      900

catgtcattg cagaggatgt gaagctcctc cagttccatg tggccaccat ggtggacaat      960

gagctgcctg gcttgccccg tgccatgcag aagtctgggc gtcccctcaa gtccctgaag     1020

cagcggttga agggcaagga aggccgggtg cgagggaacc tgatgggcaa aagagtggac     1080

ttctcggccc gtactgtcat cacccccgac cccaacctct ccattgacca ggttggcgtg     1140

ccccgctcca ttgctgccaa catgaccttt gcggagattg tcaccccctt caacattgac     1200

agacttcaag aactagtgcg cagggggaac agccagtacc caggcgccaa gtacatcatc     1260

cgagacaatg gtgatcgcat tgacttgcgt ttccacccca agcccagtga ccttcacctg     1320

cagaccggct ataaggtgga acggcacatg tgtgatgggg acattgttat cttcaaccgg     1380

cagccaactc tgcacaaaat gtccatgatg gggcatcggg tccgcattct cccatggtct     1440

acctttcgct tgaatcttag tgtgacaact ccgtacaatg cagactttga cggggatgag     1500

atgaacttgc acctgccaca gtctctggag acgcgagcag agatccagga gctggccatg     1560

gttcctcgca tgattgtcac cccccagagc aatcggcctg tcatgggtat tgtgcaggac     1620

acactcacag cagtgcgcaa attcaccaag agagacgtct tcctggagcg gggtgaagtg     1680

atgaacctcc tgatgttcct gtcgacgtgg gatgggaagg tcccacagcc ggccatccta     1740

aagccccggc ccctgtggac aggcaagcaa atcttctccc tcatcatacc tggtcacatc     1800

aattgtatcc gtacccacag cacccatccc gatgatgaag acagtggccc ttacaagcac     1860

atctctcctg gggacaccaa ggtggtggtg gagaatgggg agctgatcat gggcatcctg     1920

tgtaagaagt ctctgggcac gtcagctggc tccctggtcc acatctccta cctagagatg     1980

ggtcatgaca tcactcgcct cttctactcc aacattcaga ctgtcattaa caactggctc     2040

ctcatcgagg gtcatactat tggcattggg gactccattg ctgattctaa gacttaccag     2100

gacattcaga acactattaa gaaggccaag caggacgtaa tagaggtcat cgagaaggca     2160

cacaacaatg agctggagcc caccccaggg aacactctgc ggcagacgtt tgagaatcag     2220

gtgaaccgca ttcttaacga tgcccgagac aagactggct cctctgctca gaaatccctg     2280

tctgaataca ataacttcaa gtctatggtc gtgtccggag ctaaaggttc caagattaac     2340

atctcccagg tcattgctgt cgttggacag cagaacgtcg agggcaagcg gattccattt     2400

ggcttcaagc accggactct gcctcacttc atcaaggatg actacgggcc tgagagccgt     2460

ggctttgtgg agaactccta cctagccggc ctcacaccca ctgagttctt tttccacgcc     2520

atggggggtc gtgaggggct cattgacacg gctgtcaaga ctgctgagac tggatacatc     2580

cagcggcggc tgatcaagtc catggagtca gtgatggtga agtacgacgc gactgtgcgg     2640

aactccatca accaggtggt gcagctgcgc tacggcgaag acggcctggc aggcgagagc     2700

gttgagttcc agaacctggc tacgcttaag ccttccaaca aggcttttga gaagaagttc     2760

cgctttgatt ataccaatga gagggccctg cggcgcactc tgcaggagga cctggtgaag     2820

gacgtgctga gcaacgcaca catccagaac gagttggagc gggaatttga gcggatgcgg     2880

gaggatcggg aggtgctcag ggtcatcttc ccaactggag acagcaaggt cgtcctcccc     2940

tgtaacctgc tgcggatgat ctggaatgct cagaaaatct tccacatcaa cccacgcctt     3000

ccctccgacc tgcaccccat caaagtggtg gagggagtca aggaattgag caagaagctg     3060

gtgattgtga atggggatga cccactaagt cgacaggccc aggaaaatgc cacgctgctc     3120

ttcaacatcc acctgcggtc cacgttgtgt tcccgccgca tggcagagga gtttcggctc     3180

agtggggagg ccttcgactg gctgcttggg gagattgagt ccaagttcaa ccaagccatt     3240

gcgcatcccg gggaaatggt gggggctctg gctgcgcagt cccttggaga acctgccacc     3300

cagatgacct tgaatacctt ccactatgct ggtgtgtctg ccaagaatgt gacgctgggt     3360

gtgccccgac ttaaggagct catcaacatt tccaagaagc caaagactcc ttcgcttact     3420

gtcttcctgt tgggccagtc cgctcgagat gctgagagag ccaaggatat tctgtgccgt     3480

ctggagcata caacgttgag gaaggtgact gccaacacag ccatctacta tgaccccaac     3540

ccccagagca cggtggtggc agaggatcag gaatgggtga atgtctacta tgaaatgcct     3600

gactttgatg tggcccgaat ctccccctgg ctgttgcggg tggagctgga tcggaagcac     3660

atgactgacc ggaagctcac catggagcag attgctgaaa agatcaatgc tggttttggt     3720

gacgacttga actgcatctt taatgatgac aatgcagaga agctggtgct ccgtattcgc     3780

atcatgaaca gcgatgagaa caagatgcaa gaggaggaag aggtggtgga caagatggat     3840

gatgatgtct tcctgcgctg catcgagtcc aacatgctga cagatatgac cctgcagggc     3900

atcgagcaga tcagcaaggt gtacatgcac ttgccacaga cagacaacaa gaagaagatc     3960

atcatcacgg aggatgggga attcaaggcc ctgcaggagt ggatcctgga gacggacggc     4020

gtgagcttga tgcgggtgct gagtgagaag gacgtggacc ccgtacgcac cacgtccaat     4080

gacattgtgg agatcttcac ggtgctgggc attgaagccg tgcggaaggc cctggagcgg     4140

gagctgtacc acgtcatctc ctttgatggc tcctatgtca attaccgaca cttggctctc     4200

ttgtgtgata ccatgacctg tcgtggccac ttgatggcca tcacccgaca cggagtcaac     4260

cgccaggaca caggaccact catgaagtgt tcctttgagg aaacggtgga cgtgcttatg     4320

gaagcagccg cacacggtga gagtgacccc atgaaggggg tctctgagaa tatcatgctg     4380

ggccagctgg ctccggccgg cactggctgc tttgacctcc tgcttgatgc agagaagtgc     4440

aagtatggca tggagatccc caccaatatc cccggcctgg gggctgctgg acccaccggc     4500

atgttctttg gttcagcacc cagtcccatg ggtggaatct ctcctgccat gacaccttgg     4560

aaccagggtg caacccctgc ctatggcgcc tggtccccca gtgttgggag tggaatgacc     4620

ccaggggcag ccggcttctc tcccagtgct gcgtcagatg ccagcggctt cagcccaggt     4680

tactcccctg cctggtctcc cacaccgggc tccccggggt ccccaggtcc ctcaagcccc     4740

tacatccctt caccaggtgg tgccatgtct cccagctact cgccaacgtc acctgcctac     4800

gagccccgct ctcctggggg ctacacaccc cagagtccct cttattcccc cacttcaccc     4860

tcctactccc ctacctctcc atcctattct ccaaccagtc ccaactatag tcccacatca     4920

cccagctatt cgccaacgtc acccagctac tcaccgacct ctcccagcta ctcacccacc     4980

tctcccagct actcgcccac ctctcccagc tactcgccca cctctcccag ctactcaccc     5040

acttccccta gctactcgcc cacttcccct agctactcgc caacgtctcc cagctactcg     5100

ccgacatctc ccagctactc gccaacttca cccagctatt ctcccacttc tcccagctac     5160

tcacctacct ctccaagcta ttcacccacc tcccccagct actcacccac ttccccaagt     5220

tactcaccca ccagcccgaa ctattctcca accagtccca attacacccc aacatcaccc     5280

agctacagcc cgacatcacc cagctattca cctactagtc ccaactacac acctaccagc     5340

cctaactaca gcccaacctc tccaagctac tctccaacat cacccagcta ttccccgacc     5400

tcaccaagtt actccccttc cagcccacga tacacaccac agtctccaac ctatacccca     5460

agctcaccca gctacagccc cagctcgccc agctacagcc caacctcacc caagtacacc     5520

ccaaccagtc cttcttacag tcccagctcc ccagagtata ccccaacctc tcccaagtac     5580

tcacctacca gtcccaaata ttcacccacc tctcccaagt actcgcctac cagtcccacc     5640

tattcaccca ccaccccaaa atactcccca acatctccta cttattcccc aacctctcca     5700

gtctacaccc caacctctcc caagtactca cctactagcc ccacttactc gcccacttcc     5760

cccaagtact cgcccaccag ccccacctac tcgcccacct cccccaaagg ctcaacctac     5820

tctcccactt cccctggtta ctcgcccacc agccccacct acagtctcac aagcccggct     5880

atcagcccgg atgacagtga cgaggagaac tga                                  5913


<210>  1368
<211>  819
<212>  DNA
<213>  homo sapiens

<400>  1368
atgggaaaca ccaccagcga ccgggtgtcc ggggagcgcc acggcgccaa ggctgcacgc       60

tccgagggcg caggcggcca tgccccgggg aaggagcaca agatcatggt ggggagtacg      120

gacgacccca gcgtgttcag cctccctgac tccaagctcc ctggggacaa agagtttgta      180

tcatggcagc aggatttgga ggactccgta aagcccacac agcaggcccg gcccactgtt      240

atccgctggt ctgaaggagg caaggaggtc ttcatctctg ggtccttcaa caattggagc      300

accaagattc cactgattaa gagccataat gactttgttg ccatcctgga cctccctgag      360

ggagagcacc aatacaagtt ctttgtggat ggacagtggg ttcatgatcc atcagagcct      420

gtggttacca gtcagcttgg cacaattaac aatttgatcc atgtcaagaa atctgatttt      480

gaggtgttcg atgctttaaa gttagattct atggaaagtt ctgagacatc ttgtagagac      540

ctttccagct cacccccagg gccttatggt caagaaatgt atgcgtttcg atctgaggaa      600

agattcaaat ccccacccat ccttcctcct catctacttc aagttattct taacaaagac      660

actaatattt cttgtgaccc agccttactc cctgagccca accatgttat gctgaaccat      720

ctctatgcat tgtccattaa ggacagtgtg atggtcctta gcgcaaccca tcgctacaag      780

aagaagtatg ttactactct gctatacaag cccatttga                             819


<210>  1369
<211>  2010
<212>  DNA
<213>  homo sapiens

<400>  1369
atgcaaaatt ctcacatgga tgaatacaga aattctagta atggcagcac aggcaacagt       60

tcagaggtag tggtagaaca tcctactgat ttcagtactg agattatgaa cgttacagaa      120

atggaacagt cacctgatga ctctcccaat gtgaatgcat ctacagaaga aactgaaatg      180

gcaagtgctg tggaccttcc agtgacgctg acagaaacag aagcaaattt ccctccagaa      240

tatgaaaaat tttggaaaac tgtagaaaat aatcctcagg attttacagg ctgggtatat      300

ttgcttcaat atgtagaaca ggagaatcac ttgatggctg ccaggaaggc atttgacaga      360

tttttcatac actatccgta ttgctatggt tactggaaaa agtatgcaga ccttgaaaag      420

cggcacgaca acattaaacc atcagatgag gtttatcggc gggggcttca ggcaatacct      480

cttagtgttg acctttggat acattatata aacttcttaa aagaaacatt ggaccctggt      540

gatcctgaga caaacaatac aataagagga acttttgagc atgctgttct agctgcagga      600

acagatttcc gttctgacag actgtgggaa atgtatataa actgggaaaa tgagcaggga      660

aacctgagag aagttacagc tatatatgat cgtattcttg gtattccaac acagctgtat      720

agtcatcatt ttcagagatt taaagaacat gtacagaata atttgcctag agatctttta      780

actggtgaac agtttattca gttgcgaagg gaattagctt ctgtaaatgg tcatagtggt      840

gatgatggtc ctcctggtga tgatctacca tcgggaattg aagacataac cgatcctgca      900

aagctaatta cagaaataga aaacatgaga catagaatca ttgagattca tcaagaaatg      960

tttaattata atgagcatga agttagtaaa aggtggacat ttgaagaagg tattaaaaga     1020

ccttactttc atgtgaaacc tttggaaaag gcacaactaa aaaactggaa agaatactta     1080

gaatttgaaa ttgaaaatgg gactcatgaa cgagttgtgg ttctctttga aagatgtgtc     1140

atatcatgtg ccctctatga ggagttttgg attaagtatg ccaagtacat ggaaaaccat     1200

agcattgaag gagtgaggca tgtcttcagc agagcttgta ctatacatct cccaaagaaa     1260

cccatggtgc atatgctttg ggcagctttt gaggaacagc agggtaatat taatgaagcc     1320

aggaatatct tgaaaacatt tgaagaatgt gttctaggat tggcaatggt tcgtttacga     1380

agagtaagtt tagaacgacg gcatggaaat ctggaagaag ctgaacattt gcttcaggat     1440

gccattaaga atgccaaatc aaataatgaa tcttcatttt atgctgtcaa actagcccgg     1500

catcttttca aaatacagaa aaaccttcca aaatcaagaa aggtgctttt ggaagcaatc     1560

gaaagagaca aagagaacac aaagttatac ctcaatttac ttgaaatgga atatagtggt     1620

gacctcaaac aaaatgaaga aaatatccta aattgttttg acaaagctgt acatggttca     1680

ttacctatta aaatgagaat tacattttct cagagaaaag tggaatttct tgaagatttt     1740

ggttccgatg ttaataagct tctgaatgct tatgatgaac atcaaacact cctgaaagaa     1800

caggattctt taaaaaggaa agcagaaaat ggatcagaag aaccagagga aaagaaagca     1860

catacagaag atacaacttc atcatctaca cagatgattg atggtgattt acaggcaaac     1920

caagctgtat ataattatag tgcgtggtat caatacaatt atcagaatcc ttggaattat     1980

ggacaatatt atcctccccc tccaacctga                                      2010


<210>  1370
<211>  1362
<212>  DNA
<213>  homo sapiens

<400>  1370
atggaggact acctgcaggg ttgtcgagct gctctgcagg agtcccgacc tctacatgtt       60

gtgctgggaa atgaagcctg tgatttggac tccacagtgt ctgctcttgc cctggctttt      120

tacctagcaa agacaactga ggctgaggaa gtctttgtgc cagttttaaa tataaaacgt      180

tctgaactac ctctgcgagg tgacattgtc ttctttcttc agaaggttca tattccagag      240

agtatcttga tttttcggga tgagattgac ctccatgcat tataccaggc tggccaactc      300

accctcatcc ttgtcgacca tcatatctta tccaaaagtg acacagccct agaggaggca      360

gtagcagagg tgctagacca tcgacccatc gagccgaaac actgccctcc ctgccatgtt      420

tcagttgagc tggtggggtc ctgtgctacc ctggtgaccg agagaatcct gcagggggca      480

ccagagatct tggacaggca aactgcagcc cttctgcatg gaaccatcat cctggactgt      540

gtcaacatgg accttaaaat tggaaaggca accccaaagg acagcaaata tgtggagaaa      600

ctagaggccc ttttcccaga cctacccaag agaaatgata tatttgattc cctacaaaag      660

gcaaagtttg atgtatcagg actgaccact gagcagatgc tgagaaaaga ccagaagact      720

atctatagac aaggcgtcaa ggtggccatt agtgcaatat atatggattt ggaggccttt      780

ctgcagaggt ctaacctcct tgcagatctc catgctttct gccaggctca cagctatgat      840

gtcctggttg ccatgactat ctttttcaac actcacaatg agccagtgcg gcagttggct      900

attttctgtc cccatgtggc actccaaaca acgatctgtg aagtcctgga acgctcccac      960

tctccacccc tgaagctgac ccctgcctca agtacccacc ctaacctcca tgcctatctt     1020

caaggcaaca cccaggtctc tcgaaagaaa cttctgcccc tgctccagga agccctgtca     1080

gcatattttg actccatgaa gatcccttca ggacagcctg agacagcaga tgtgtccagg     1140

gagcaagtgg acaaggaatt ggacagggca agtaactccc tgatttctgg cctgagtcaa     1200

gatgaggagg accctccgct gcccccgacg cccatgaaca gcttggtgga tgagtgccct     1260

ctagatcagg ggctgcctaa actctctgct gaggccgtct tcgagaagtg cagtcagatc     1320

tcactgtcac agtctaccac agcctccctg tccaagaagt ga                        1362


<210>  1371
<211>  1515
<212>  DNA
<213>  homo sapiens

<400>  1371
atggcagccc aggctttggc gctgctgaga gaggtagcga ggctggaagc gccgctggag       60

gagctacgcg cgcttcactc cgtgctgcag gcagtgccgc tcaacgagct tcgccagcaa      120

gcggcggagc tgcgcctcgg cccgctcttc tccctgctta acgagaacca tagggaaaag      180

actactttgt gtgtatccat tctggagaga ttgctccaag ctatggaacc ggttcacgtg      240

gcccggaacc tcagggttga cctgcagagg ggactaattc accctgatga ttctgtaaaa      300

atcctcactc tttcccagat tggaagaatt gttgaaaatt ctgatgctgt tactgagatt      360

ctaaataatg ctgaattact aaaacaaatt gtttattgca ttggtggaga gaatctatct      420

gtagcaaaag cggctatcaa atccctgtca agaatatcac taacccaagc tggactggag      480

gctttatttg aaagcaatct gctggatgat ttgaaaagtg taatgaaaac aaatgacatt      540

gttcgataca gggtgtatga gctaattata gagatttctt ccgtgtcacc agaatcttta      600

aactactgta ccacaagtgg attggtaacc cagctcctga gagagctgac tggtgaggat      660

gtgttggtca gagccacctg tatagaaatg gtgacatcac tggcatatac tcatcatggg      720

cgacaatatc ttgctcaaga aggagtaatt gaccaaattt ctaatataat tgttggggca      780

gattcagacc ctttctctag cttctatctg ccaggattcg tgaagttttt tggaaacctg      840

gctgtcatgg atagtcctca acagatctgt gagcgttatc ctatctttgt ggaaaaagtc      900

tttgaaatga tagaaagtca ggaccccact atgattggtg tagctgtaga cacagttgga      960

atcttgggat ccaatgttga aggaaaacag gttttacaga aaacaggaac tcgctttgaa     1020

cgcttgctta tgagaatagg acatcaatca aagaatgccc cagtggagct aaaaattaga     1080

tgtttggatg caatttcatc tcttctgtac ttaccacctg agcagcagac tgatgacctt     1140

ctgaggatga cagaatcctg gttttcttct ttatctcggg atccactgga gctcttccgt     1200

ggcattagta gtcagccctt ccctgaacta cactgtgctg ccttaaaagt gtttacggcc     1260

attgcaaacc aaccctgggc tcagaaactt atgtttaaca gtccaggttt tgtagaatat     1320

gtggtggacc ggtctgtgga gcatgacaaa gcttcaaagg atgccaaata tgaactagtg     1380

aaagcacttg ccaattccaa gacaattgca gaaatctttg ggaacccaaa ttatttgagg     1440

ctcagaactt acctgagtga agggccatac tatgtgaaac ctgtttccac gacagcagta     1500

gaaggagccg aatga                                                      1515


<210>  1372
<211>  1800
<212>  DNA
<213>  homo sapiens

<400>  1372
atgagccgga gtctcttgct ctggttcttg ctgttcctgc tcctgctccc gccgctcccc       60

gtcctgctcg cggacccagg ggcgcccacg ccagtgaatc cctgttgtta ctatccatgc      120

cagcaccagg gcatctgtgt ccgcttcggc cttgaccgct accagtgtga ctgcacccgc      180

acgggctatt ccggccccaa ctgcaccatc cctggcctgt ggacctggct ccggaattca      240

ctgcggccca gcccctcttt cacccacttc ctgctcactc acgggcgctg gttctgggag      300

tttgtcaatg ccaccttcat ccgagagatg ctcatgcgcc tggtactcac agtgcgctcc      360

aaccttatcc ccagtccccc cacctacaac tcagcacatg actacatcag ctgggagtct      420

ttctccaacg tgagctatta cactcgtatt ctgccctctg tgcctaaaga ttgccccaca      480

cccatgggaa ccaaagggaa gaagcagttg ccagatgccc agctcctggc ccgccgcttc      540

ctgctcagga ggaagttcat acctgacccc caaggcacca acctcatgtt tgccttcttt      600

gcacaacact tcacccacca gttcttcaaa acttctggca agatgggtcc tggcttcacc      660

aaggccttgg gccatggggt agacctcggc cacatttatg gagacaatct ggagcgtcag      720

tatcaactgc ggctctttaa ggatgggaaa ctcaagtacc aggtgctgga tggagaaatg      780

tacccgccct cggtagaaga ggcgcctgtg ttgatgcact acccccgagg catcccgccc      840

cagagccaga tggctgtggg ccaggaggtg tttgggctgc ttcctgggct catgctgtat      900

gccacgctct ggctacgtga gcacaaccgt gtgtgtgacc tgctgaaggc tgagcacccc      960

acctggggcg atgagcagct tttccagacg acccgcctca tcctcatagg ggagaccatc     1020

aagattgtca tcgaggagta cgtgcagcag ctgagtggct atttcctgca gctgaaattt     1080

gacccagagc tgctgttcgg tgtccagttc caataccgca accgcattgc catggagttc     1140

aaccatctct accactggca ccccctcatg cctgactcct tcaaggtggg ctcccaggag     1200

tacagctacg agcagttctt gttcaacacc tccatgttgg tggactatgg ggttgaggcc     1260

ctggtggatg ccttctctcg ccagattgct ggccggatcg gtgggggcag gaacatggac     1320

caccacatcc tgcatgtggc tgtggatgtc atcagggagt ctcgggagat gcggctgcag     1380

cccttcaatg agtaccgcaa gaggtttggc atgaaaccct acacctcctt ccaggagctc     1440

gtaggagaga aggagatggc agcagagttg gaggaattgt atggagacat tgatgcgttg     1500

gagttctacc ctggactgct tcttgaaaag tgccatccaa actctatctt tggggagagt     1560

atgatagaga ttggggctcc cttttccctc aagggtctcc tagggaatcc catctgttct     1620

ccggagtact ggaagccgag cacatttggc ggcgaggtgg gctttaacat tgtcaagacg     1680

gccacactga agaagctggt ctgcctcaac accaagacct gtccctacgt ttccttccgt     1740

gtgccggatg ccagtcagga tgatgggcct gctgtggagc gaccatccac agagctctga     1800


<210>  1373
<211>  1506
<212>  DNA
<213>  homo sapiens

<400>  1373
atgaaccgca gccgccaggt gacgtgcgtg gcctgggtcc gctgcggcgt ggccaaagag       60

acaccagaca aggtagagct gagtaaagaa gaagtaaaac gcctcattgc tgaggcaaag      120

gagaaattgc aagaagaagg tggtggcagt gatgaagagg agacaggcag tccttcagaa      180

gatggcatgc agagtgcacg cacccaggca cgcccaagag agcccctgga ggatggtgac      240

ccagaggatg acaggacgct tgatgatgat gagctggctg agtacgactt agataaatat      300

gatgaggaag gtgacccaga tgctgagact cttggtgaat ctctcttggg tcttacggtc      360

tacgggagta atgatcaaga tccttacgtt actctgaaag atacagaaca atatgaacgt      420

gaagatttct tgattaagcc cagtgataat cttatagttt gtggccgagc tgaacaggac      480

cagtgcaatt tagaggtgca tgtttataat caagaagaag actcttttta tgtacaccat      540

gatatactct tgtctgcata tcctctgagt gtggaatggc tgaattttga tcctagccca      600

gatgattcta ctggaaatta cattgctgta ggaaacatga cccctgttat tgaagtgtgg      660

gaccttgata tagtggactc tttagagcca gtcttcacac tcggaagtaa actttcaaaa      720

aagaagaaaa agaaaggaaa gaagagttcc tcagcagaag ggcataccga tgctgtcctt      780

gacctttcat ggaataagct aatcagaaat gttttagcaa gtgcatcagc tgacaacact      840

gtaattctgt gggatatgtc cttggggaaa ccagcagcta gcctcgctgt acacacagac      900

aaggtccaaa cactgcagtt tcatccattt gaagcacaga ctctgatttc tggctcatat      960

gataagtcag tggctttgta tgactgccga agtccagatg aaagccatcg aatgtggcga     1020

ttcagtgggc agatagagag agtgacttgg aatcactttt caccttgtca tttcttggcc     1080

agtacagatg acggctttgt atataatttg gatgcacgtt cagataagcc aatttttaca     1140

cttaatgcac acaatgatga aatctctggt cttgatctta gcagtcaaat caagggctgt     1200

ctcgtgactg cttcagctga caaatacgtg aagatctggg acatcttagg agataggcca     1260

agtctagttc attctaggga catgaaaatg ggagttctct tctgttcttc atgttgccct     1320

gatttgccat ttatttatgc ctttggaggt caaaaagaag ggcttcgggt ctgggatata     1380

agcacagtct cttcagtaaa tgaagcattt ggaagacgag agaggcttgt tcttgggagt     1440

gcaagaaatt catctattag tggccctttt ggcagcagga gctcagatac acccatggag     1500

tcttaa                                                                1506


<210>  1374
<211>  1539
<212>  DNA
<213>  homo sapiens

<400>  1374
atgatgctgt ccgagcaagc ccaaaagtgg tttccaaccc acgtgcaggt cacagtgctc       60

caagccaaag atctgaagcc aaaaggcaaa agtggtacca atgacacata cactataatt      120

cagctgggca aggaaaagta ctccacctct gtagctgaga aaacccttga gccagtttgg      180

aaggaggagg cctctttcga gctacctgga ttgctaattc agggaagtcc agagaaatac      240

attcttttcc ttatagttat gcacaggtcc ctggtgggtc tggataaatt tttagggcag      300

gtggcaatca atctcaatga catctttgag gacaaacaaa gaaggaaaac agagtggttt      360

agattagaat ccaaacaagg aaaacgaatc aaaaacaggg gtgagataaa ggtcaatatt      420

cagtttatga ggaacaatat gaccgcaagt atgtttgact tatcaatgaa ggacaaaacc      480

agatctcctt ttgcaaagtt aaaagataag atgaagggta gaaaaaatga tggaacattt      540

tctgatacgt cttctgcaat cattccaagt actcacatgc ccgatgccaa tagtgaattt      600

tcaagtggtg aaatacagat gaaatccaaa ccaaaaaagc cttttctctt gggtcctcag      660

cgactctcgt cagcgcattc aatgtctgat ttatctgggt cccatatgtc ttctgagaaa      720

ctgaaggctg gcaccatagg tcaaacacat cttctcggac accagttaga ttcctttgga      780

acagttccag aaagtggaag tctcaaatct ccacacagaa gaacattaag ctttgatact      840

tctaaaatga accaacctga cagcattgtg gatgaaggtg aattgtgttt cggaagacaa      900

aatgacccat ttacaaatgt gactgcttca ttaccccaaa aatttgcaac actgccaagg      960

aagaaaaatc catttgaaga aagcagcgaa acatgggaca gcagcatgaa tttattttca     1020

aaaccaattg aaataagaaa agaaaataaa agagagaaaa gggagaaagt tagcctgttt     1080

gaaagagtga ctggaaaaaa agatagcaga agatctgata aacttaacaa tgggggatct     1140

gatagccctt gtgacttgaa atcacctaat gcatttagtg aaaatcgcca ggactatttt     1200

gattatgagt caaccaatcc atttacagca aaattcaggg cttcaaatat aatgccatct     1260

tcaagttttc atatgagtcc aacaagcaat gaagacctca ggaaaatccc ggacagcaac     1320

ccctttgatg ccactgcagg gtatcgtagt ctgacctatg aagaggttct acaggagctg     1380

gtgaaacaca aagaactcct taggaggaaa gacacccaca tccgggaact cgaggactac     1440

atcgacaacc tccttgtaag ggtaatggaa gaaacgccca gtattctcag agtgccgtat     1500

gaaccatcca ggaaagctgg caaattctct aacagttaa                            1539


<210>  1375
<211>  2448
<212>  DNA
<213>  homo sapiens

<400>  1375
atggaggtca gagcttcatt acagaaggtt agtggatcat ctgattctgt ggctacaatg       60

aacagtgaag aatttgtttt ggttcctcag tatgcagatg ataattctac aaaacatgaa      120

gaaaaacctc aactgaagat agtttctaat ggtgatgaac aattggaaaa agccatggaa      180

gagattttga gagattccga gaaaaggcca agcagtcttc ttgttgattg tcaaagttcc      240

agtgagattt cagaccattc gtttggagat attccagcca gccaaacaaa taagccatct      300

cttcagttaa ttttggatcc gtctaacaca gaaatttcta cacccagacc atcttctcca      360

ggtggactac ctgaagaaga tagtgtttta tttaataaac tgacctactt aggatgtatg      420

aaggtttctt ccccacgtaa tgaagtagag gctttacggg caatggcaac catgaaatct      480

tccagtcaat acccctttcc tgttaccctg tatgtaccaa atgttccaga aggttctgtg      540

agaattatag accaatccag caatgtggag atagcatctt ttccaatcta taaggtgtta      600

ttctgtgcac gtggacatga cggaacaaca gagagcaatt gctttgcatt tacagagagt      660

tcccatggtt cggaagaatt tcagatacat gttttctcct gtgaaattaa agaggcagta      720

agcagaattt tgtacagttt ctgtacagca ttcaaacgtt cttccagaca agtgtctgat      780

gttaaagact cagttattcc tacccccgac agtgatgtgt ttaccttcag tgtctccttg      840

gaggtaaaag aagacgatgg aaaaggaaac tttagccctg tgcctaagga tagagataaa      900

ttttatttca aattaaagca aggaatagag aagaaggttg tgattacagt gcagcaactt      960

tctaacaaag aattagctat tgaaagatgt tttggaatgt tattaagccc aggtcgaaac     1020

gtgaagaaca gtgacatgca tttactggat atggaatcca tgggaaagag ctatgatggg     1080

agagcttatg tcatcactgg catgtggaac cccaatgcac cagtatttct ggcacttaac     1140

gaggaaaccc caaaagataa gcaagtatac atgactgtgg cagtggatat ggtagtcaca     1200

gaggtggtgg agcctgttcg ctttctcctg gagacagtag tccgtgtgta ccctgcaaat     1260

gagcgatttt ggtatttcag cagaaagact ttcacagaga ctttcttcat gagattgaaa     1320

cagtctgagg gaaaaggcca taccaatgct ggagatgcaa tatatgaggt ggtgagtcta     1380

cagcgagagt ctgacaagga ggaaccagtc actcctacta gtggaggggg tccaatgtca     1440

ccccaggatg atgaagcaga agaggagagt gataatgaac tctcaagtgg aacaggtgat     1500

gtgtctaagg attgtcctga gaagatcctg tattcttggg gagagttgct aggaaaatgg     1560

cacagtaacc ttggtgcacg accgaaaggg ctgtctactc tggtgaagag tggtgtccct     1620

gaagcattga gggcagaggt atggcagtta ttggcaggct gccatgacaa ccaggcaatg     1680

ctggatagat accgaattct tatcacaaag gactcagccc aggagagtgt tattactcga     1740

gatattcatc gtacatttcc cgcacatgat tactttaaag atactggagg agatggtcaa     1800

gaatcgctct ataagatctg caaggcctac tctgtgtatg atgaagacat tgggtactgt     1860

caagggcagt cttttcttgc tgctgtatta ctgctgcata tgccagagga acaagcattc     1920

tgtgttttgg tgaaaatcat gtacgactat ggtttgagag acctctacag aaacaacttc     1980

gaagatcttc attgcaaatt ctaccagttg gagagactaa tgcaggaaca gctaccggac     2040

ctgcatagcc atttttctga tctgaacctg gaagctcata tgtatgcatc ccagtggttt     2100

ctcactcttt ttactgccaa gttcccactc tgcatggtgt tccacatcat tgacttactg     2160

ctttgtgagg gtttgaacat aatctttcat gtagctttgg ctctcctaaa gacctcaaag     2220

gaagaccttc tgcaggctga ttttgaaggt gctttaaagt tctttagagt tcagcttcca     2280

aagagataca gggcagagga aaatgcaaga agactgatgg agcaggcttg caatattaaa     2340

gtaccaacca agaagctgaa gaaatatgag aaagaatatc agacaatgcg agagagtcag     2400

ctgcaacagg aagacccaat ggatagatac aagtttgtat atttgtag                  2448


<210>  1376
<211>  3939
<212>  DNA
<213>  homo sapiens

<400>  1376
atgtcccgga tcgaaaagat gagcattctg ggcgtgcgga gttttggaat agaggacaaa       60

gataagcaaa ttatcacttt cttcagcccc cttacaattt tggttggacc caatggggcg      120

ggaaagacga ccatcattga atgtctaaaa tatatttgta ctggagattt ccctcctgga      180

accaaaggaa atacatttgt acacgatccc aaggttgctc aagaaacaga tgtgagagcc      240

cagattcgtc tgcaatttcg tgatgtcaat ggagaactta tagctgtgca aagatctatg      300

gtgtgtactc agaaaagcaa aaagacagaa tttaaaactc tggaaggagt cattactaga      360

acaaagcatg gtgaaaaggt cagtctgagc tctaagtgtg cagaaattga ccgagaaatg      420

atcagttctc ttggggtttc caaggctgtg ctaaataatg tcattttctg tcatcaagaa      480

gattctaatt ggcctttaag tgaaggaaag gctttgaagc aaaagtttga tgagattttt      540

tcagcaacaa gatacattaa agccttagaa acacttcggc aggtacgtca gacacaaggt      600

cagaaagtaa aagaatatca aatggaacta aaatatctga agcaatataa ggaaaaagct      660

tgtgagattc gtgatcagat tacaagtaag gaagcccagt taacatcttc aaaggaaatt      720

gtcaaatcct atgagaatga acttgatcca ttgaagaatc gtctaaaaga aattgaacat      780

aatctctcta aaataatgaa acttgacaat gaaattaaag ccttggatag ccgaaagaag      840

caaatggaga aagataatag tgaactggaa gagaaaatgg aaaaggtttt tcaagggact      900

gatgagcaac taaatgactt atatcacaat caccagagaa cagtaaggga gaaagaaagg      960

aaattggtag actgtcatcg tgaactggaa aaactaaata aagaatctag gcttctcaat     1020

caggaaaaat cagaactgct tgttgaacag ggtcgtctac agctgcaagc agatcgccat     1080

caagaacata tccgagctag agattcatta attcagtctt tggcaacaca gctagaattg     1140

gatggctttg agcgtggacc attcagtgaa agacagatta aaaattttca caaacttgtg     1200

agagagagac aagaagggga agcaaaaact gccaaccaac tgatgaatga ctttgcagaa     1260

aaagagactc tgaaacaaaa acagatagat gagataagag ataagaaaac tggactggga     1320

agaataattg agttaaaatc agaaatccta agtaagaagc agaatgagct gaaaaatgtg     1380

aagtatgaat tacagcagtt ggaaggatct tcagacagga ttcttgaact ggaccaggag     1440

ctcataaaag ctgaacgtga gttaagcaag gctgagaaaa acagcaatgt agaaacctta     1500

aaaatggaag taataagtct ccaaaatgaa aaagcagact tagacaggac cctgcgtaaa     1560

cttgaccagg agatggagca gttaaaccat catacaacaa cacgtaccca aatggagatg     1620

ctgaccaaag acaaagctga caaagatgaa caaatcagaa aaataaaatc taggcacagt     1680

gatgaattaa cctcactgtt gggatatttt cccaacaaaa aacagcttga agactggcta     1740

catagtaaat caaaagaaat taatcagacc agggacagac ttgccaaatt gaacaaggaa     1800

ctagcttcat ctgagcagaa taaaaatcat ataaataatg aactaaaaag aaaggaagag     1860

cagttgtcca gttacgaaga caagctgttt gatgtttgtg gtagccagga ttttgaaagt     1920

gatttagaca ggcttaaaga ggaaattgaa aaatcatcaa aacagcgagc catgctggct     1980

ggagccacag cagtttactc ccagttcatt actcagctaa cagacgaaaa ccagtcatgt     2040

tgccccgttt gtcagagagt ttttcagaca gaggctgagt tacaagaagt catcagtgat     2100

ttgcagtcta aactgcgact tgctccagat aaactcaagt caacagaatc agagctaaaa     2160

aaaaaggaaa agcggcgtga tgaaatgctg ggacttgtgc ccatgaggca aagcataatt     2220

gatttgaagg agaaggaaat accagaatta agaaacaaac tgcagaatgt caatagagac     2280

atacagcgcc taaagaacga catagaagaa caagaaacac tcttgggtac aataatgcct     2340

gaagaagaaa gtgccaaagt atgcctgaca gatgttacaa ttatggagag gttccagatg     2400

gaacttaaag atgttgaaag aaaaattgca caacaagcag ctaagctaca aggaatagac     2460

ttagatcgaa ctgtccaaca agtcaaccag gagaaacaag agaaacagca caagttagac     2520

acagtttcta gtaagattga attgaatcgt aagcttatac aggaccagca ggaacagatt     2580

caacatctaa aaagtacaac aaatgagcta aaatctgaga aacttcagat atccactaat     2640

ttgcaacgtc gtcagcaact ggaggagcag actgtggaat tatccactga agttcagtct     2700

ttgtacagag agataaagga tgctaaagag caggtaagcc ctttggaaac aacattggaa     2760

aagttccagc aagaaaaaga agaattaatc aacaaaaaaa atacaagcaa caaaatagca     2820

caggataaac tgaatgatat taaagagaag gttaaaaata ttcatggcta tatgaaagac     2880

attgagaatt atattcaaga tgggaaagac gactataaga agcaaaaaga aactgaactt     2940

aataaagtaa tagctcaact aagtgaatgc gagaaacaca aagaaaagat aaatgaagat     3000

atgagactca tgagacaaga tattgataca cagaagatac aagaaaggtg gctacaagat     3060

aaccttactt taagaaaaag aaatgaggaa ctaaaagaag ttgaagaaga aagaaaacaa     3120

catttgaagg aaatgggtca aatgcaggtt ttgcaaatga aaagtgaaca tcagaagttg     3180

gaagagaaca tagacaatat aaaaagaaat cataatttgg cattagggcg acagaaaggt     3240

tatgaagaag aaattattca ttttaagaaa gaacttcgag aaccacaatt tcgggatgct     3300

gaggaaaagt atagagaaat gatgattgtt atgaggacaa cagaacttgt gaacaaggat     3360

ctggatattt attataagac tcttgaccaa gcaataatga aatttcacag tatgaaaatg     3420

gaagaaatca ataaaattat acgtgacctg tggcgaagta cctatcgtgg acaagatatt     3480

gaatacatag aaatacggtc tgatgccgat gaaaatgtat cagcttctga taaaaggcgg     3540

aattataact accgagtggt gatgctgaag ggagacacag ccttggatat gcgaggacga     3600

tgcagtgctg gacaaaaggt attagcctca ctcatcattc gcctggccct ggctgaaacg     3660

ttctgcctca actgtggcat cattgccttg gatgagccaa caacaaatct tgaccgagaa     3720

aacattgaat ctcttgcaca tgctctggtt gagataataa aaagtcgctc acagcagcgt     3780

aacttccagc ttctggtaat cactcatgat gaagattttg tggagctttt aggacgttct     3840

gaatatgtgg agaaattcta caggattaaa aagaacatcg atcagtgctc agagattgtg     3900

aaatgcagtg ttagctccct gggattcaat gttcattaa                            3939


<210>  1377
<211>  2943
<212>  DNA
<213>  homo sapiens

<400>  1377
atggtttcta aaatgatcat tgaaaacttc gaggcactca agtcctggct cagcaagact       60

ctcgagccca tctgtgatgc agatccatcc gccctagcaa aatatgttct ggctttggta      120

aagaaagaca aaagtgaaaa agagttaaag gcattatgta ttgatcagct ggatgtattt      180

cttcagaaag agacacagat atttgtggaa aaactttttg atgctgtgaa tacaaagagt      240

tacctacctc ctccagagca gccatcatca ggaagcctga aggtagaatt ttttccacac      300

caagaaaaag atataaagaa ggaagagatc actaaggagg aagagcgaga gaagaagttt      360

tctagaaggc taaatcacag tcctccccag tcaagctccc gatacaggga aaatagaagc      420

cgtgatgaga ggaaaaaaga tgatcgttct cgcaaaagag attatgatcg aaaccctcct      480

cgaagagatt catacagaga ccggtacaat agaagacgag ggcggagtcg cagttatagc      540

aggagtcgaa gtcgaagttg gagtaaagag aggcttcgtg agagggacag agatagaagc      600

aggactagaa gcagaagcag aacacgaagc agggaaaggg atctggtaaa acctaaatat      660

gacctggata gaacagatcc attagaaaat aattatactc cagtctcttc ggtacctagt      720

atttcatctg gccactaccc tgtacctact ttgagcagca ctattacagt aattgctcct      780

actcatcatg gaaacaacac taccgaaagt tggtctgaat ttcatgaaga ccaagtggac      840

cataactctt acgtaagacc acccatgcca aagaaacggt gtagagacta tgatgaaaag      900

ggtttttgta tgagaggaga catgtgtcct tttgatcatg gaagtgatcc agtagttgta      960

gaagatgtga atcttcctgg tatgctgcct ttcccagcac agcctcctgt tgttgaagga     1020

ccacctcctc ctggactccc cccacctcca ccaattctta cacccccacc tgtgaatctc     1080

aggcccccag taccaccgcc aggtccattg ccacccagtc tcccacctgt tacaggacca     1140

ccacctccac ttcctccttt gcagccatct ggcatggatg ctcctccaaa ctctgcaacc     1200

agttctgttc ctactgtagt aacaactggc attcatcacc agcctcctcc tgctccaccc     1260

tctcttttta ctgcagatac atatgacaca gatggctaca atcctgaagc cccaagcata     1320

acaaacactt ccagacctat gtatagacac agagtgcatg cacaaaggcc caacttgata     1380

ggactaacat caggggatat ggatttgcca cccagagaaa agcctcccaa taaaagcagt     1440

atgaggatag tagtggactc agaatcaagg aaaagaacca ttggttctgg agagcctgga     1500

gttcctacaa agaagacttg gtttgataaa ccaaatttta atagaacaaa cagcccaggc     1560

tttcagaaga aggttcaatt tggaaatgaa aataccaagc ttgaacttag aaaagttcct     1620

ccagaattaa ataatatcag caaacttaat gaacatttta gtcgatttgg aaccttggtt     1680

aacttacagg ttgcttataa tggtgatcct gaaggtgccc taatccaatt tgcaacatac     1740

gaagaagcaa agaaagcaat atcaagtacg gaagcagtat taaacaatcg ctttattaag     1800

gtttattggc acagagaagg aagcacccaa cagttacaaa ctacttctcc aaagccttta     1860

gtccagcagc ccattttgcc tgttgtgaag cagtcagtca aagagcggct gggtccagta     1920

ccttcaagta ctattgaacc tgcagaagcc cagagtgcct cttcagacct tcctcaggtg     1980

ttgtctacat ctactggcct aacaaaaaca gtgtataatc cagctgcttt gaaggctgca     2040

cagaaaacct tacttgtttc cacctctgca gttgataata atgaagcaca gaaaaaaaaa     2100

caggaggcat tgaaacttca gcaggatgta aggaaaagga aacaagaaat tttagaaaag     2160

cacattgaaa cacagaagat gttaatttca aaactggaga aaaacaaaac aatgaagtct     2220

gaagataaag cagaaataat gaaaacttta gaggttttga caaaaaatat taccaagttg     2280

aaagatgagg tcaaagctgc ttctcctgga cgctgtcttc caaaaagtat aaaaaccaag     2340

actcagatgc agaaggaatt acttgacaca gaactggatt tatataagaa gatgcaggct     2400

ggagaagaag tcactgaact taggagaaag tatacagaat tacagctgga agctgccaaa     2460

cgagggattc tttcatctgg tcggggcaga ggaattcatt caagaggtcg aggtgcagtt     2520

catggccgag gcagggggcg agggcgaggg cgaggtgtgc ctggtcatgc tgtggtggat     2580

caccgtccca gggcattgga gatttctgca tttacggaga gcgatagaga agatcttctt     2640

cctcattttg cgcaatatgg tgaaattgaa gattgtcaga ttgatgattc ctcacttcat     2700

gcagtaatta cattcaagac aagagcagaa gctgaagcag ctgcagttca tggagctcgt     2760

ttcaaagggc aagatctaaa actggcatgg aataaaccag taactaatat ttcagctgtt     2820

gaaacagaag aagttgagcc tgatgaagaa gaatttcagg aagagtcttt ggtggatgac     2880

tcattacttc aagatgatga tgaagaagaa gaggacaatg aatctcgttc ttggagaaga     2940

tga                                                                   2943


<210>  1378
<211>  1656
<212>  DNA
<213>  homo sapiens

<400>  1378
atggaagaag aacttcctct tttctctgga gacagtggca agccagtaca ggctactctg       60

tcatctttga agatgttaga tgtgggaaag tggccaattt tttccctttg ttctgaagaa      120

gaactacagt taattcgtca ggcttgtgtc tttggcagtg ctggcaatga agttttatac      180

actacagtaa atgatgagat ttttgtgctt ggcacaaact gctgtggctg tttggggtta      240

ggtgacgtcc agagcaccat tgaacctcgg agactggatt ctttaaatgg caaaaaaata      300

gcctgcctca gctatgggag tggtccacat attgtccttg caacaacaga aggagaagtc      360

tttacctggg gtcataatgc ttatagccag ctgggcaatg ggacaactaa tcatggttta      420

gtgccctgtc atatctctac taatctgtca aacaaacaag tcattgaagt tgcctgtggg      480

tcttaccatt ctttggtgct aacatctgat ggagaggtat ttgcctgggg ttataataac      540

tctgggcagg taggatctgg atcaacagtt aatcagccaa tccctcgaag agtcactggc      600

tgcctacaaa ataaagtagt tgtgaccata gcatgtgggc agatgtgctg catggcagta      660

gtagacacgg gggaggtcta tgtctggggt tacaacggaa acgggcagct tggactcggc      720

aacagtggca accagccaac cccttgcaga gtggcagctt tgcaaggcat ccgtgtccag      780

agggtcgcct gtggctacgc acacacatta gtattaacag atgaaggcca agtgtatgct      840

tggggcgcca attcttatgg gcagttgggc actggcaata aaagcaacca gtcctatcct      900

actcctgtca ctgtggaaaa ggacaggatt atcgagattg cagcctgtca ctccacacac      960

acgtctgcgg ccaagacgca gggtgggcac gtgtacatgt ggggccagtg ccggggtcag     1020

tccgtgatcc tcccgcacct cacccacttc tcctgcactg acgacgtgtt tgcctgcttt     1080

gccacgcccg ccgtcacgtg gcgcctcctc tccgtggaac ctgatgacca cctcacagtg     1140

gctgagtcac tgaagaggga atttgacaac ccggacactg cagacctgaa gtttctagtt     1200

gatggaaagt acatttatgc acataaagtc cttctcaaga ttcgatgtga gcattttcgt     1260

tcgtcattgg aagataacga ggatgatatt gtagaaatga gtgaattttc atatcctgtt     1320

taccgggcct tcctggaata cctatacaca gacagcatca gcctttctcc tgaggaggca     1380

gtaggactgc tagacttggc tacattttat agagaaaatc gtttgaaaaa gctctgccaa     1440

caaactatca agcaaggcat ctgcgaggag aatgccatcg ctctgctctc ggctgcggtg     1500

aagtatgatg cacaggattt agaagaattc tgcttcaggt tttgcataaa ccatctgact     1560

gtagtaacac aaacatcagg ttttgcagaa atggaccatg atctcctgaa gaactttatc     1620

agcaaagcaa gcagagttgg agcctttaaa aattga                               1656


<210>  1379
<211>  1752
<212>  DNA
<213>  homo sapiens

<400>  1379
atgccgaaac caatcaacgt aagagtaact acaatggatg ctgagctgga atttgccatt       60

cagcccaata caactggcaa acaacttttt gaccaggtgg tgaaaacagt tggtttgcgt      120

gaggtctggt tttttgggct gcagtatgta gacagcaaag gttattctac atggcttaaa      180

ctaaataaaa aggtaacaca gcaggatgtt aaaaaagaga atcctttaca gttcaagttt      240

agagctaaat tctttcctga agatgtttct gaggaattaa ttcaagaaat aacccagaga      300

ctcttcttct tgcaagttaa agaagccatc ttaaatgatg agatatattg cccgccagaa      360

actgcagttc ttttggcttc ctatgctgtc caagccaagt atggagatta caataaagag      420

attcataagc caggctacct ggctaatgat agactcctac cccagcgtgt attggaacaa      480

cacaaactaa caaaagaaca gtgggaagaa agaatacaga actggcatga agaacataga      540

ggaatgttaa gggaggattc tatgatggaa tacctgaaga ttgcacaaga tctagaaatg      600

tatggagtca actattttga aataaaaaat aaaaaaggaa ctgaattgtg gctaggtgtt      660

gatgctttgg gtctgaatat ttatgagcat gacgacaagt taacacctaa aattggtttt      720

ccctggagtg aaatcagaaa tatttcattt aatgacaaaa aatttgttat aaagccaatc      780

gacaaaaagg cacctgattt tgtgttttat gcacctcgtc tgagaatcaa taagcggatt      840

ttggccttat gtatgggaaa ccatgaacta tacatgcgaa gaaggaagcc tgatactatt      900

gaagtacaac agatgaaggc tcaggctagg gaggagaaac atcagaagca gttggaaagg      960

gcacaattag agaatgaaaa gaagaaaaga gaaatagcag aaaaggaaaa ggaaagaata     1020

gaacgtgaaa aggaagagct aatggaacgt ctaaaacaaa ttgaagagca gacaattaaa     1080

gctcagaaag aactagaaga acagactcga aaagctctag aactggatca agaacgaaaa     1140

cgagcaaaag aagaagcaga acgacttgaa aaggagcgtc gagctgctga agaggcaaag     1200

tctgccatag caaaacaagc tgccgaccag atgaagaatc aggagcagct agcagcagaa     1260

cttgctgaat tcactgccaa gattgcactt ctagaggaag ccaagaagaa aaaggaagag     1320

gaagctactg agtggcaaca caaagctttt gcagcccagg aagacttgga aaagaccaaa     1380

gaagagttaa aaactgtgat gtctgccccc cctccacctc caccaccacc agtcattcct     1440

ccaacagaaa acgaacatga tgaacacgat gagaataatg ctgaagctag tgctgaatta     1500

tcaaatgaag gggtaatgaa ccatagaagc gaggaagaac gtgtaaccga aacacagaaa     1560

aatgagcgtg ttaagaagca acttcaggca ttaagttcag aattagccca agccagagat     1620

gaaaccaaga aaacacaaaa tgatgttctt catgctgaga atgttaaagc aggccgtgat     1680

aagtacaaga ctctgcgaca gattcgacaa ggcaatacaa agcagcgtat cgatgagttt     1740

gaagcaatgt ga                                                         1752


<210>  1380
<211>  2388
<212>  DNA
<213>  homo sapiens

<400>  1380
atggaaggct taacgctgag cgatgcggag cagaaatact attcagatct cttctcctac       60

tgcgacattg agagcaccaa gaaggtggtg gtcaacgggc gggtgctgga gctgttccgg      120

gccgcgcagc tgccgaacga cgtggtccta cagatcatgg agctttgtgg tgcaacaaga      180

cttggttatt ttggaagaag tcagttctac attgctttga aacttgtagc tgttgcccag      240

tctggtttcc ctttaagagt ggaaagtata aatacagtaa aggaccttcc tctgccaaga      300

tttgttgctt caaagaatga acaggaatct cgccatgcag cctcatattc ttcagattct      360

gaaaatcaag ggtcgtattc tggtgtaatt cccccaccac ctggcagggg gcaagtgaaa      420

aagggatccg taagccatga tacggttcag cctcgtacat ctgcagatgc acaggaacct      480

gcatccccag tagtttcacc acagcaatcc ccaccaactt ctccacacac atggaggaag      540

cacagccgtc atcccagcgg tgggaatagt gagaggcctc tcgcgggacc tgggccattt      600

tggtctccct ttggtgaagc acaatcaggt tcttctgctg gtgatgcagt gtggtcaggg      660

cattccccac ctccacctca agaaaactgg gtcagttttg cagatactcc accaaccagt      720

actcttttaa ccatgcatcc tgcttctgtc caggaccaga caacagtacg aactgtagca      780

tcagctacaa ctgccattga aattcgtagg caatccagta gttatgatga tccctggaaa      840

ataacagatg aacaaagaca gtattatgta aatcagttta aaaccattca gcctgatcta      900

aacggattta ttccaggatc tgcagctaaa gagtttttta caaaatcaaa acttcctatt      960

cttgaacttt ctcatatttg ggaactctca gactttgata aagatggtgc attgacactg     1020

gatgagtttt gtgctgcttt tcatctggtg gttgctagga agaatggcta tgatttacca     1080

gaaaaacttc ctgaaagctt aatgcccaaa ctgattgatt tggaagattc agcagatgtt     1140

ggggatcagc caggtgaggt aggttattca ggctctcctg ctgaagctcc tccaagcaag     1200

tcaccatcga tgccatcact aaaccagaca tggcctgagc tgaatcagag cagtgagcag     1260

tgggagacat ttagtgaacg ctcttcaagc tcacaaactc tgacccaatt tgattctaac     1320

attgcaccag ctgatcctga tactgctatt gttcatccag ttcccattcg tatgactcca     1380

agcaaaatcc acatgcagga aatggaactt aaaagaactg gcagcgatca tacaaatccc     1440

actagcccat tacttgtgaa accatctgac cttttagaag aaaataagat aaattcatcg     1500

gtgaaattcg cttctggtaa tactgtagat ggttacagta gttcagactc ttttacttct     1560

gacccagaac agatcgggag caatgtaact cgtcaaaggt ctcattcagg aacgtcgcct     1620

gataacactg caccaccacc tccccctcca aggccacagc cctctcattc tagatcatca     1680

tctttagata tgaatcggac ctttacagtc accacaggac aacaacaggc tggagttgtt     1740

gcccatcctc ctgcagtgcc tccaagacca cagccctcac aggctcctgg tcctgctgtg     1800

catcgcccag tggatgccga tggcctcata actcacacta gtacctcacc tcagcagata     1860

ccagagcaac caaattttgc agatttcagt cagtttgaag tatttgctgc atcaaatgta     1920

aacgacgaac aagatgatga agccgagaaa catccagaag tcctgccggc tgaaaaagct     1980

tctgatcctg caagttctct tcgagttgcc aaaacagata gtaaaactga agaaaagaca     2040

gctgctagtg ctcctgccaa tgtgagcaaa ggcacaacac cacttgctcc accacctaaa     2100

cctgttcgaa gaagattaaa atcagaagat gaattaaggc cagaagttga tgaacataca     2160

caaaagacgg gtgtcttagc tgctgttctt gcatcacaac cttctattcc cagatctgtt     2220

gggaaagata agaaagctat tcaggcatca attagacgta ataaggaaac caacaccgtt     2280

ttggccagat tgaatagcga attgcagcaa caattaaagg atgttcttga ggagagaatt     2340

tccctggaag ttcaactgga acaacttcga ccattctctc acctataa                  2388


<210>  1381
<211>  3444
<212>  DNA
<213>  homo sapiens

<400>  1381
atggacattc ggaaattctt tggagtaata ccaagtggaa agaaacttgt aagtgaaaca       60

gtaaagaaga atgagaaaac aaagtctgat gaagaaactt taaaagcaaa gaaaggaata      120

aaggaaatca aggtaaatag ctcccgtaaa gaggatgact tcaaacaaaa gcaaccaagc      180

aagaaaaaga ggatcatcta tgattcagat tcagagtcag aggagacgtt gcaggtaaaa      240

aatgccaaaa agccaccaga aaaactgcca gtatcttcta aacctggtaa aatttcacgg      300

caggatcctg ttacatacat ttcagaaaca gatgaagaag atgactttat gtgtaagaag      360

gcggcctcta aatcaaaaga gaatggaaga tctacaaata gtcatcttgg aacatcaaac      420

atgaaaaaga atgaagaaaa cactaagacc aagaataagc ctttatcacc aataaaactt      480

acacccacat cagtacttga ttattttgga actggaagtg tccaaagatc taataagaag      540

atggtggcaa gcaaaagaaa agagctttca caaaatacag atgagtctgg attaaatgat      600

gaagccatcg ccaagcaatt acagcttgat gaagatgcgg agctggagag gcagttgcat      660

gaagatgaag agtttgccag aacattagcc atgttggatg aagaacccaa gaccaaaaag      720

gctcgaaagg acacagaagc gggagaaacg ttttcatctg tccaagccaa tttaagtaaa      780

gcagaaaaac ataaatatcc tcataaagta aaaacagcac aagtttcaga tgaaagaaag      840

agctacagtc ctaggaagca aagtaaatat gaaagttcaa aagaatctca gcaacattcc      900

aagtcatcag ctgacaaaat aggagaagtc tcttctccca aggccagttc taagctggca      960

attatgaaaa gaaaagaaga gagctcttat aaagaaatag agcctgtggc ctcaaaaaga     1020

aaagaaaatg ccattaaatt gaaaggagag acaaaaactc ctaagaaaac caaaagttct     1080

ccagctaaaa aagagtctgt aagtcctgaa gattctgaaa agaaacgcac taattatcaa     1140

gcttatcgaa gctacttaaa tcgagaaggt cccaaggctc tgggctccaa agaaatacca     1200

aagggagctg aaaattgctt ggaaggcctt atatttgtaa tcacaggcgt gctggagtct     1260

attgaacgag atgaggccaa gtctctaatt gaacgttatg ggggaaaagt aacaggaaat     1320

gtcagcaaga aaacaaatta tcttgtcatg ggtcgtgata gtggacagtc caagagtgat     1380

aaggccgcag ccttggggac aaaaattatt gatgaagatg gcctgttgaa tctgattcgg     1440

actatgccag gcaagaaatc caagtatgaa atagcagttg aaactgagat gaagaaagag     1500

tccaaactgg agagaacacc ccaaaaaaat gtccaaggaa aaagaaaaat tagtccatct     1560

aaaaaggaat cagaatctaa aaagagcagg ccgacttcca aaagggacag tttggcaaag     1620

acaataaaaa aggaaacaga tgtgttttgg aaaagcctgg atttcaagga gcaggtggct     1680

gaggagacaa gtggtgacag caaggctagg aatttggctg atgacagcag tgaaaacaaa     1740

gtggaaaatt tgctctgggt ggataaatat aagccaacct cgctcaagac cataattgga     1800

cagcaaggtg accagagctg tgccaacaaa ctcctacgct ggctccgaaa ctggcaaaag     1860

agttcttccg aagataaaaa acacgcaaag tttggtaaat tttccggcaa agatgatggc     1920

tctagtttta aagcagcgtt gctgtcaggc cctcctggtg ttggcaaaac caccacagct     1980

tccctggtgt gtcaggagtt gggatacagc tacgtggaac tgaatgcaag tgacacccgg     2040

agtaagagca gtttgaaggc gattgttgct gagtcactga acaataccag catcaaaggc     2100

ttttattcaa atggagcagc ctcttcagta agcacgaaac atgctctcat catggatgaa     2160

gtagatggca tggcaggcaa tgaggatagg ggaggaattc aggaattaat tggcctgata     2220

aaacatacta aaattcccat tatttgtatg tgcaatgata gaaatcatcc caagattcgc     2280

tctctggttc attattgttt tgatcttcgt tttcaaagac ctcgggttga acagattaag     2340

ggtgctatga tgtctattgc atttaaagaa ggtttaaaga ttccccctcc agctatgaat     2400

gaaataattt tgggagccaa tcaagatatc agacaggttt tacataatct gagtatgtgg     2460

tgtgcacgaa gtaaagcatt aacctatgac caggccaaag ctgattctca cagagccaaa     2520

aaggatatca aaatgggccc atttgatgtt gcccggaaag tgtttgcagc tggagaggag     2580

actgctcaca tgtcacttgt ggacaagtca gatctctttt ttcatgatta ttcaatagca     2640

cccctcttcg tccaggaaaa ttacatacac gtgaagcctg tagcagcagg gggtgacatg     2700

aaaaagcacc tgatgctttt aagcagagca gcagacagca tatgcgatgg tgacctagtg     2760

gacagccaga tccggagtaa gcaaaactgg agtcttctgc ctgcgcaggc catttatgcc     2820

agtgttcttc ctggagagtt gatgaggggg tacatgaccc agtttcccac cttcccaagc     2880

tggctgggga agcactcgtc tacaggcaaa catgatcgta ttgttcagga cctggccttg     2940

catatgagtc tcagaactta ctccagcaaa aggactgtaa acatggatta tctgtcgctt     3000

ctaagggatg cacttgtaca gcccttgacc tcacaaggag tagacggagt acaggatgtt     3060

gttgcactta tggacacata ttatttgatg aaagaagact ttgagaatat catggaaatc     3120

agcagctggg gtggcaaacc tagtcccttt tcaaagctgg atcccaaggt gaaagcagcc     3180

ttcacaagag cttacaataa ggaagcccac cttactccat actcacttca agctataaag     3240

gcatctagac acagcacaag cccatccctg gattcggaat acaatgaaga attaaatgaa     3300

gatgactctc aatctgatga gaaagaccaa gatgctatag aaactgatgc catgatcaag     3360

aaaaagacaa aatcttcaaa gccttcaaaa ccagaaaaag ataaggagcc cagaaaagga     3420

aaaggaaaaa gttcgaagaa atga                                            3444


<210>  1382
<211>  636
<212>  DNA
<213>  homo sapiens

<400>  1382
atgcaaagtg ctatgttctt ggctgttcaa cacgactgca gacccatgga caagagcgca       60

ggcagtggcc acaagagcga ggagaagcga gaaaagatga aacggaccct tttaaaagat      120

tggaagaccc gtttgagcta cttcttacaa aattcctcta ctcctgggaa gcccaaaacc      180

ggcaaaaaaa gcaaacagca agctttcatc aagccttctc ctgaggaagc acagctgtgg      240

tcagaagcat ttgacgagct gctagccagc aaatatggtc ttgctgcatt cagggctttt      300

ttaaagtcgg aattctgtga agaaaatatt gaattctggc tggcctgtga agacttcaaa      360

aaaaccaaat caccccaaaa gctgtcctca aaagcaagga aaatatatac tgacttcata      420

gaaaaggaag ctccaaaaga gataaacata gattttcaaa ccaaaactct gattgcccag      480

aatatacaag aagctacaag tggctgcttt acaactgccc agaaaagggt atacagcttg      540

atggagaaca actcttatcc tcgtttcttg gagtcagaat tctaccagga cttgtgtaaa      600

aagccacaaa tcaccacaga gcctcatgct acatga                                636


<210>  1383
<211>  1659
<212>  DNA
<213>  homo sapiens

<400>  1383
atggggaaag tgaatgtggc caagttgcgt tacatgagcc gagatgactt cagggtcttg       60

accgcggttg aaatgggcat gaagaaccat gaaattgttc ccggcagttt gattgcttct      120

atagccagcc ttaaacatgg tggctgtaat aaagttttaa gagaattagt gaaacataaa      180

ctcatagctt gggagcgtac caaaactgtc cagggctatc ggttgacaaa tgcaggatat      240

gattacctag ctttgaaaac actttcttct aggcaagtag ttgagtctgt tggaaaccag      300

atgggtgttg gcaaagaatc agatatttac attgttgcaa atgaagaagg acaacaattt      360

gcattaaagc ttcacagact aggaagaacc tcgtttcgaa atttgaaaaa caaacgcgat      420

tatcataaac ataggcacaa tgtgtcatgg ctatatttat ctcgtctctc tgccatgaag      480

gaatttgcct atatgaaggc attgtatgag aggaaatttc cagttccaaa gccaattgat      540

tacaatcgtc atgcagtggt catggaactc ataaatggtt atccactatg tcagatacac      600

catgttgaag atcctgcatc agtatatgat gaagctatgg aactaattgt caaacttgca      660

aatcatgggc tgattcatgg agattttaat gaatttaatc tcattttgga tgaaagtgac      720

catatcacca tgattgattt tccacagatg gtttcaactt ctcatcccaa tgctgagtgg      780

tattttgaca gagatgttaa atgcattaaa gatttcttta tgaaacgttt cagctacgaa      840

agtgagcttt ttccaacttt taaggatatc aggagagaag acactcttga tgtggaggtt      900

tctgccagtg gctacacaaa ggaaatgcag gcagatgatg aactgcttca tccattaggt      960

ccagatgata aaaatattga aacaaaagag ggatctgaat tctcattttc agatggagaa     1020

gtggcagaaa aagcagaggt ttacgggtca gaaaatgaaa gtgaacggaa ctgtctagaa     1080

gaatcagagg gctgctattg cagatcatct ggagaccctg aacaaataaa ggaagacagt     1140

ttatcagaag agagtgctga tgcacggagt tttgaaatga ctgaattcaa tcaagcttta     1200

gaagaaataa aagggcaggt tgttgaaaac aactctgtaa ctgaattttc tgaggagaaa     1260

aacagaactg aaaattacaa caggcaagat ggtcagagag ttcaaggagg agtccctgct     1320

ggctctgacg agtatgaaga tgaatgccct catctaattg ccttgtcgtc attaaataga     1380

gaattcaggc ctttcagaga tgaagaaaat gtgggagcta tgaatcagta tagaacaaga     1440

actctgagta tcacttcttc aggcagtgct gtaagctgtt caacaattcc tccagaactg     1500

gtgaaacaga aggtgaaacg tcagttgaca aaacagcaaa aatcagctgt cagacgtcga     1560

ttgcagaaag gagaagcaaa tatatttacc aagcaacgta gggaaaacat gcaaaatatc     1620

aaatcaagtt tggaagcagc cagcttttgg ggagaataa                            1659


<210>  1384
<211>  1350
<212>  DNA
<213>  homo sapiens

<400>  1384
atgccagcca cactcctcag agccgtggcc agatctcatc atatattatc aaaagcacat       60

cagtgccgaa gaatcggtca tctaatgtta aaaccactta aggaatttga aaatacaaca      120

tgcagcacac tgacaatacg tcaaagcttg gatttgttcc ttcctgataa aacagctagt      180

ggtttgaata agtctcagat cctggaaatg aaccaaaaaa agtcagatac cagcatgctg      240

tctccattaa atgctgctcg ttgccaagat gaaaaggcac accttccaac catgaaatcc      300

tttggtactc acaggagagt gacccacaaa ccaaatctgt tgggttctaa atggtttata      360

aaaatattaa agaggcattt ctcatctgta tcaacggaaa catttgttcc aaaacaagac      420

ttcccacagg tgaagagacc actaaaagca tccaggacca gacagccatc caggaccaac      480

cttccagttc tgtctgtgaa cgaggaccta atgcactgca cagcatttgc aacggcagat      540

gagtatcatc tgggaaatct gtctcaagat ctggcctccc acggatatgt tgaagtaaca      600

agcttgccta gagatgcagc aaatattttg gtgatgggtg tggaaaattc tgcaaaagaa      660

ggtgatcctg gaacaatatt cttcttcagg gaaggagctg ctgtgttttg gaatgtgaaa      720

gacaaaacta tgaagcatgt gatgaaagtt ctagaaaaac atgaaattca gccctatgaa      780

atcgcactgg tacactggga aaatgaagaa cttaactaca taaaaataga gggacagtca      840

aaacttcaca ggggggaaat caagttaaat tcagagctgg atttagatga tgccattcta      900

gagaagtttg ctttctccaa tgctctatgc ctttctgtaa aactggcaat ttgggaagca      960

tcactggata aatttattga atctattcag tcaattcctg aggctttaaa agctgggaag     1020

aaagtgaaac tatctcatga agaagttatg cagaaaatcg gtgaactctt tgctctaagg     1080

caccgtataa acttgagttc agacttcctg attactcctg atttctactg ggacagagaa     1140

aacctggaag gactttacga taaaacgtgt caattcctta gcattggccg aagagttaag     1200

gtcatgaatg aaaaacttca gcactgcatg gaactaacag atctaatgcg gaatcacctg     1260

aatgagaaga gggcactccg cttggagtgg atgattgtca tcctcattac catagaggta     1320

atgtttgagc tgggacgagt atttttctga                                      1350


<210>  1385
<211>  777
<212>  DNA
<213>  homo sapiens

<400>  1385
atggccaaat atcaaggtga agttcaaagt ttgaaactgg atgatgattc agttatagaa       60

ggagtaagcg accaagtact tgtggcagtt gtggtcagtt tcgctttgat tgctaccctg      120

gtatatgcac ttttcagaaa tgtacatcaa aacattcacc cagaaaacca ggagctagta      180

agggtacttc gagaacagct tcaaacagaa caggatgcac ctgctgccac tcgacagcag      240

ttctacactg acatgtactg tcccatctgc ctgcaccaag cctccttccc ggtggagacc      300

aactgtggac atcttttttg tggtgcctgc attattgctt actggcgata tggttcatgg      360

cttggggcaa tcagttgtcc aatctgtaga caaacggtaa ccttactcct aacagtattt      420

ggtgaagatg atcagtctca ggatgttctg agattgcatc aggatattaa tgattataac      480

cggagattct cagggcaacc cagatctatt atggagagaa ttatggatct acccacttta      540

ctgaggcatg cattcaggga aatgttttca gtcgggggcc ttttctggat gtttcgcatc      600

aggataatac tttgtttaat gggagctttt ttctatctta tatcacctct agattttgta      660

cctgaagcct tgtttggaat tctaggcttt ctagatgatt tctttgtcat ctttttattg      720

cttatctaca tctctattat gtatcgagaa gtgataaccc aaaggctaac tagatga         777


<210>  1386
<211>  1431
<212>  DNA
<213>  homo sapiens

<400>  1386
atggcaaatt ctgcaaaagc agaagaatat gaaaagatgt ctcttgaaca ggcaaaagcg       60

tcagtgaatt ctgaaacaga gtcttcattc aatattaatg aaaacacaac agcttctggg      120

actgggcttt ctgaaaagac ttctgtctgt aggcaagtag acatagcaag aaagagaaaa      180

gagtttgaag atgatcttgt aaaggaaagt tctagttgtg ggaaagacac tccatccaag      240

aagagaaaac ttgatcctga aattgtccca gaggaaaaag attgtggtga tgctgaaggc      300

aattcaaaga aaagaaaaag agaaactgag gatgttccaa aagataaatc ttctactgga      360

gatggcactc aaaataagag aaaaatagca cttgaggatg ttcctgaaaa gcagaaaaat      420

ctggaagaag gacacagctc aacagtggct gcccattaca atgaacttca ggaagttggt      480

ttggagaagc gtagtcaaag tcgtattttt tacctaagaa actttaataa ttggatgaaa      540

agtgttctca ttggagaatt tttggaaaag gtacgacaga agaaaaaacg tgatatcact      600

gttttggacc tgggatgtgg taaaggtgga gatttgctga aatggaaaaa aggaagaatt      660

aacaagctag tttgtactga tattgccgat gtttctgtca aacagtgtca gcagcggtat      720

gaggacatga aaaatcgtcg tgatagtgaa tatattttca gtgcagaatt tataactgct      780

gacagctcaa aggaacttct gattgacaaa tttcgtgacc cacaaatgtg ttttgacatc      840

tgcagttgtc agtttgtctg tcattactca tttgagtctt atgagcaggc tgacatgatg      900

ctgagaaatg cgtgtgagag acttagccct gggggctatt ttattggtac tactcccaat      960

agctttgaat tgataagacg ccttgaagct tcagaaacag aatcatttgg aaatgaaata     1020

tatactgtga aatttcagaa gaaaggagat tatcctttat ttggctgcaa atatgacttc     1080

aacttggaag gtgttgtgga tgttcctgaa ttcttggtct attttccatt gctaaatgaa     1140

atggcaaaga agtacaatat gaaactagtc tacaaaaaaa catttctgga attctacgaa     1200

gaaaagatta agaacaatga aaataaaatg ctcttaaaac gaatgcaggc cttggagcca     1260

tatcctgcaa atgagagttc taaacttgtc tctgagaagg tggatgacta tgaacatgca     1320

gcaaagtaca tgaagaacag tcaagtaagg ttacctttgg gaaccttaag taaatcagaa     1380

tgggaagcta caagtattta cttggtgttt gcctttgaga aacagcagtg a              1431


<210>  1387
<211>  1200
<212>  DNA
<213>  homo sapiens

<400>  1387
atgtccctgc agtacggggc ggaggagacg cccctcgccg gcagttacgg cgcggccgat       60

tcgtttccaa aggacttcgg ctacggcgtg gaggaggagg aagaggaggc ggcggcggcg      120

ggcggagggg ttggggcagg ggcaggcggt ggctgtggtc cggggggcgc tgacagctcc      180

aagccgagga ttctgctcat gggactccgg cgcagcggca agtcctccat ccagaaggtg      240

gtgtttcata agatgtcacc caacgagacc ctctttttgg aaagtaccaa caagatttat      300

aaggatgaca tttccaatag ctcctttgtg aatttccaga tatgggattt tcctgggcaa      360

atggactttt ttgacccaac ctttgactat gagatgatct tcaggggaac aggagcattg      420

atatacgtca ttgacgcaca ggatgactac atggaggctt taacaagact tcacattact      480

gtttctaaag cctacaaagt taacccagac atgaattttg aggtttttat tcacaaagtt      540

gatggtctgt ctgatgatca caaaatagaa acacagaggg acattcatca aagggccaat      600

gatgaccttg cagatgctgg gctagaaaaa ctccatctta gcttttatct gactagtatc      660

tatgaccatt caatatttga agcctttagt aaggtggtgc agaaactcat tccacaactg      720

ccgaccttgg aaaacctatt aaatatcttt atatcaaatt caggtattga aaaagctttt      780

ctctttgatg ttgtcagcaa aatctacatt gcaacagaca gttcccctgt ggatatgcaa      840

tcttatgaac tttgctgtga catgatcgat gttgtaattg atgtgtcttg tatatatggg      900

ttaaaggaag atggaagtgg aagtgcttat gacaaagaat ctatggcaat tatcaagctg      960

aataatacaa ctgtccttta tttaaaggag gtgactaaat ttttggcact ggtctgcatt     1020

ctaagggaag aaagctttga aagaaaaggt ttaatagact acaacttcca ctgtttccga     1080

aaagctattc atgaggtttt tgaggtgggt gtgacttctc acaggagctg tggtcaccag     1140

actagtgcct ccagtctgaa agcgctgaca cacaatggca cgccacgaaa cgccatctag     1200


<210>  1388
<211>  1227
<212>  DNA
<213>  homo sapiens

<400>  1388
atgatgtgct cacgggtgcc ctctgaacag tcttctggta cctctctctt gcctaaagac       60

ggtgccccat tttcttggga ttccttggat gaggatggat tggatgactc cttgctggag      120

ctgtcagagg gagaagaaga tgatggtgat gtaaattaca cagaggaaga gattgatgca      180

ctgttgaagg aagatgaccc atcatatgag cagtcttctg gggaagatga tggtgggcat      240

gttgagaagg gagaaagagg gagtcaaatt ctacttgata ctccccgaga gaaaaattca      300

tcgtacagcc tgggaccagt agctgagact cctgacctct tcaaactacc tcagctaagt      360

acatcaagtg gtcatggacc agctcatact aaaccattaa acagacgctc tgtactagaa      420

aagaatctta taaaagtaac tgttgcacca tttaatccaa cagtttgtga tgctctgctt      480

gataaggacg agactgattc gtccaaagat actgaaaaac tctcttccct tggagaagag      540

atgagagaag atggtcttag cccaaatgaa agcaaacttt gtactgaatc tgaagggatc      600

agccccaata actctgcctg gaatgggccc cagctctctt cttcaaacaa taactttcaa      660

cagactgtct ctgataaaaa tatgcctgac agtgagaacc ctacgtctgt attctctcgg      720

atctcagacc attcagagac tcctaatatg gagttatcct gcagaaatgg tggttcacac      780

aagtcaagtt gtgaaatgag atctctggtt gtttccacct catcaaacaa acaggatgtt      840

cttaacaagg attctgggaa gatgaaaggc catgagagaa gactaggcaa agtcattcct      900

gttctacaaa ctaagaccag gactaatgtt ccgacgtttt cacagtcaaa tctagaacag      960

cagaagcagc tttatctcag gagtgtcatt gctcatatag aagacccaga ggacactaac     1020

caaggtatct cgggggagct ttgtgccttg atggatcaag ttcatcatat gcagcactca     1080

aaatggcagc atccttcgga cctcaccacg cgaaactacg cccgccgaca gaaacatctg     1140

caaagataca gtctgactca gtgggttgac aggaacatgc gaagccacca tcggttccag     1200

cgtctcccag acttctcgta cagttaa                                         1227


<210>  1389
<211>  2499
<212>  DNA
<213>  homo sapiens

<400>  1389
atgttcgctc tgggcttgcc cttcttggtg ctcttggtgg cctcggtcga gagccatctg       60

ggggttctgg ggcccaagaa cgtctcgcag aaagacgccg agtttgagcg cacctacgtg      120

gacgaggtca acagcgagct ggtcaacatc tacaccttca accatactgt gacccgcaac      180

aggacagagg gcgtgcgtgt gtctgtgaac gtcctgaaca agcagaaggg ggcgccgttg      240

ctgtttgtgg tccgccagaa ggaggctgtg gtgtccttcc aggtgcccct aatcctgcga      300

gggatgtttc agcgcaagta cctctaccaa aaagtggaac gaaccctgtg tcagcccccc      360

accaagaatg agtcggagat tcagttcttc tacgtggatg tgtccaccct gtcaccagtc      420

aacaccacat accagctccg ggtcagccgc atggacgatt ttgtgctcag gactggggag      480

cagttcagct tcaataccac agcagcacag ccccagtact tcaagtatga gttccctgaa      540

ggcgtggact cggtaattgt caaggtgacc tccaacaagg ccttcccctg ctcagtcatc      600

tccattcagg atgtgctgtg tcctgtctat gacctggaca acaacgtagc cttcatcggc      660

atgtaccaga cgatgaccaa gaaggcggcc atcaccgtac agcgcaaaga cttccccagc      720

aacagctttt atgtggtggt ggtggtgaag accgaagacc aagcctgcgg gggctccctg      780

cctttctacc ccttcgcaga agatgaaccg gtcgatcaag ggcaccgcca gaaaaccctg      840

tcagtgctgg tgtctcaagc agtcacgtct gaggcatacg tcagtgggat gctcttttgc      900

ctgggtatat ttctctcctt ttacctgctg accgtcctcc tggcctgctg ggagaactgg      960

aggcagaaga agaagaccct gctggtggcc attgaccgag cctgcccaga aagcggtcac     1020

cctcgagtcc tggctgattc ttttcctggc agttcccctt atgagggtta caactatggc     1080

tcctttgaga atgtttctgg atctaccgat ggtctggttg acagcgctgg cactggggac     1140

ctctcttacg gttaccaggg ccgctccttt gaacctgtag gtactcggcc ccgagtggac     1200

tccatgagct ctgtggagga ggatgactac gacacattga ccgacatcga ttccgacaag     1260

aatgtcattc gcaccaagca atacctctat gtggctgacc tggcacggaa ggacaagcgt     1320

gttctgcgga aaaagtacca gatctacttc tggaacattg ccaccattgc tgtcttctat     1380

gcccttcctg tggtgcagct ggtgatcacc taccagacgg tggtgaatgt cacagggaat     1440

caggacatct gctactacaa cttcctctgc gcccacccac tgggcaatct cagcgccttc     1500

aacaacatcc tcagcaacct ggggtacatc ctgctggggc tgcttttcct gctcatcatc     1560

ctgcaacggg agatcaacca caaccgggcc ctgctgcgca atgacctctg tgccctggaa     1620

tgtgggatcc ccaaacactt tgggcttttc tacgccatgg gcacagccct gatgatggag     1680

gggctgctca gtgcttgcta tcatgtgtgc cccaactata ccaatttcca gtttgacaca     1740

tcgttcatgt acatgatcgc cggactctgc atgctgaagc tctaccagaa gcggcacccg     1800

gacatcaacg ccagcgccta cagtgcctac gcctgcctgg ccattgtcat cttcttctct     1860

gtgctgggcg tggtctttgg caaagggaac acggcgttct ggatcgtctt ctccatcatt     1920

cacatcatcg ccaccctgct cctcagcacg cagctctatt acatgggccg gtggaaactg     1980

gactcgggga tcttccgccg catcctccac gtgctctaca cagactgcat ccggcagtgc     2040

agcgggccgc tctacgtgga ccgcatggtg ctgctggtca tgggcaacgt catcaactgg     2100

tcgctggctg cctatgggct tatcatgcgc cccaatgatt tcgcttccta cttgttggcc     2160

attggcatct gcaacctgct cctttacttc gccttctaca tcatcatgaa gctccggagt     2220

ggggagagga tcaagctcat ccccctgctc tgcatcgttt gcacctccgt ggtctggggc     2280

ttcgcgctct tcttcttctt ccagggactc agcacctggc agaaaacccc tgcagagtcg     2340

agggagcaca accgggactg catcctcctc gacttctttg acgaccacga catctggcac     2400

ttcctctcct ccatcgccat gttcgggtcc ttcctggtgt tgctgacact ggatgacgac     2460

ctggatactg tgcagcggga caagatctat gtcttctag                            2499


<210>  1390
<211>  978
<212>  DNA
<213>  homo sapiens

<400>  1390
atgttcgcca acctaaaata cgtttccctg ggaattttgg tctttcagac taccagtttg       60

gttctaacaa tgcgttattc cagaacttta aaagaagaag gacctcgtta tctatcttct      120

acagcagtgg ttgttgctga acttttgaag ataatggcct gcattttatt ggtctacaaa      180

gacagcaaat gtagtctaag agcactgaat cgagtactac atgatgaaat tcttaataaa      240

cctatggaaa cacttaaact tgctattcca tcagggatct atactcttca gaataattta      300

ctgtatgtgg cactatcaaa tctagatgca gctacttatc aggtcacgta tcagttaaaa      360

attcttacaa cagcattatt ttctgtgtct atgcttagta aaaaattggg tgtataccag      420

tggctgtccc tagtaatttt gatgacagga gttgcttttg tacagtggcc ctcagattct      480

cagcttgatt ctaaggaact ttcagctggt tctcaatttg taggactcat ggcagttctc      540

acagcatgtt tttcaagtgg ctttgctggg gtttactttg agaaaatctt aaaagaaaca      600

aaacaatcag tgtggataag aaatattcag cttggtttct ttggaagtat atttggatta      660

atgggtgtat acatttatga tggagaactg gtatcaaaga atggattttt tcagggatat      720

aaccgactga cctggatagt agttgttctt caggcacttg gaggccttgt aatagctgct      780

gttattaagt atgcagataa tattttaaaa ggatttgcaa cctctttatc gataatatta      840

tcaacattga tctcctattt ttggcttcaa gattttgtgc caaccagtgt ctttttcctt      900

ggagccatcc ttgtaataac agctactttt ttgtatggtt atgatcccaa acctgcagga      960

aatcccacta aagcatag                                                    978


<210>  1391
<211>  1068
<212>  DNA
<213>  homo sapiens

<400>  1391
atggcggaag ttcatagacg tcagcatgct cgggttaaag gagaagcccc cgcgaaatcc       60

tccacactcc gagatgagga ggagctgggg atggcgtcgg ccgaaacgct gaccgtgttt      120

ctgaagctgc tggccgccgg cttttacggc gtgagctcct tcctgatcgt ggtggtgaat      180

aagagcgtgc tcaccaatta cagatttccc tcctcactat gtgttggact tggccagatg      240

gtggccacag tggcagttct ctgggtggga aaggcgctca gagtagtcaa gtttcctgac      300

cttgacagaa atgtacctcg aaagacgttt ccactacctc tactatattt tgggaaccaa      360

atcacgggac tgttcagcac aaagaaactg aacttgccaa tgtttacagt tctgagaagg      420

ttctccatcc tgtttacaat gtttgctgaa ggagttttac tcaagaagac tttttcttgg      480

ggtattaaaa tgactgtatt tgcaatgatt attggagcct ttgtagctgc cagctctgac      540

ttggcatttg atctggaagg atatgctttt attctgataa acgatgtcct aacagcagca      600

aatggtgcat acgtaaaaca aaaattagat tcaaaagagc tgggaaaata tggactgctc      660

tattacaatg cactgttcat gattctgccc accctggcca ttgcgtattt cacaggagat      720

gcacaaaagg ctgtggagtt tgaaggctgg gctgacaccc tctttcttct gcagttcacc      780

ctctcctgtg tgatggggtt tatcttaatg tacgccacag tactctgcac gcagtataat      840

tctgctctta caactacaat agttggctgt attaagaata tattaataac ttatattgga      900

atggtctttg gtggagatta tattttcacg tggacaaact tcattggttt aaatatcagc      960

attgctggga gcctggtata ttcctatatc actttcactg aagagcagct gagcaaacag     1020

tcagaggcta ataacaagct ggacattaag gggaaaggag cagtgtga                  1068


<210>  1392
<211>  2133
<212>  DNA
<213>  homo sapiens

<400>  1392
atgcagggga agaagccggg cggttcgtcg ggcggcggcc ggagcggcga gctgcagggg       60

gacgaggcgc agaggaacaa gaaaaagaaa aagaaggtgt cctgcttttc caacatcaag      120

atcttcctgg tgtccgagtg cgccctgatg ctggcgcagg gcacggtggg cgcctacctg      180

gtgagcgtcc tgaccaccct ggagcgtagg ttcaacctgc agagcgctga cgtgggtgtg      240

atcgctagca gcttcgagat cgggaacctg gcgctcatcc tcttcgtgag ctacttcggg      300

gcacgcgggc accggccgcg cctgatcggc tgcggcggca tcgtcatggc gctgggcgcg      360

ctgctgtcgg cgctgcccga gttcctgacc caccagtaca agtacgaggc gggcgagatc      420

cgctggggcg ccgagggccg cgacgtctgc gcagccaacg gctcgggcgg cgacgagggg      480

cccgaccccg acctcatctg ccgcaaccgg acggctacca acatgatgta cttgctgctc      540

attggggccc aggtgctcct gggcatcggt gctacccctg tgcagcccct gggcgtctcc      600

tacatcgacg accacgtgcg gaggaaggac tcctcgctct atataggaat cctgttcacg      660

atgctggtat ttggaccagc ctgcgggttt atcctgggct ctttctgtac caaaatctac      720

gtggatgcgg tcttcattga cacaagtaac ctggacatca ctccggacga cccccgctgg      780

atcggagcct ggtggggtgg ctttctgctc tgcggtgcct tactcttctt ctcttccctc      840

ttgatgtttg ggtttccaca gtccctgccc ccgcactcag agcccgccat ggaaagcgag      900

caggccatgc tctccgaaag agaatacgag agacccaagc ccagcaacgg ggtcctgagg      960

caccccctgg agccagacag cagtgcctcc tgtttccagc agctgagagt gatcccgaag     1020

gtcaccaagc acctgctctc aaaccctgtg ttcacctgca tcatcctggc cgcctgcatg     1080

gagattgcag tggtggctgg cttcgctgcc tttttgggga agtacctgga gcagcagttt     1140

aacctcacca cctcttctgc caaccagctg cttgggatga ctgcgatccc gtgtgcttgt     1200

ctgggtatct tcctgggagg tcttttggtg aagaagctca gcctgtctgc cctgggggcc     1260

attcggatgg ccatgctcgt caacctggtg tccactgctt gctacgtctc cttcctcttc     1320

ctgggctgcg acactggccc tgtggctggg gttactgttc cctatggaaa cagcacagca     1380

cctggctcag ccctggaccc ctactcgccc tgcaataata actgtgaatg ccaaaccgat     1440

tccttcactc cagtgtgtgg ggcagatggc atcacctacc tgtctgcctg ctttgctggc     1500

tgcaacagca cgaatctcac gggctgtgcg tgcctcacca ccgtccctgc tgagaacgca     1560

accgtggttc ctggaaaatg ccccagtcct gggtgccaag aggccttcct cactttcctc     1620

tgtgtgatgt gtatctgcag cctgatcggt gccatggcac agacaccctc agtcatcatc     1680

ctcatcagga cagtcagccc tgaactcaag tcttacgctt tgggagttct ttttctcctc     1740

cttcgtttgt tgggcttcat ccctccaccc ctcatcttcg gggctggcat cgactccacc     1800

tgcctgttct ggagcacgtt ctgtggggag caaggcgcct gcgtcctcta cgacaatgtg     1860

gtctaccgat acctgtatgt cagcatcgcc atcgcgctca aatccttcgc cttcatcctg     1920

tacaccacca cgtggcagtg cctgaggaaa aactataaac gctacatcaa aaaccacgag     1980

ggcgggctga gcaccagtga gttctttgcc tctactctga ccctagacaa cctggggagg     2040

gaccctgtgc ccgcaaacca gacacatagg acaaagttta tctataacct ggaagaccat     2100

gagtggtgtg aaaacatgga gtccgtttta tag                                  2133


<210>  1393
<211>  3654
<212>  DNA
<213>  homo sapiens

<400>  1393
atgtacataa agcaggtgat tatccagggt tttcgaagtt acagagatca aacaattgta       60

gatcccttca gttcaaaaca taatgtgatt gtgggcagaa atggatctgg aaaaagtaac      120

tttttttatg caattcagtt tgttctcagt gatgagttta gtcatcttcg tccagaacag      180

cggttggctt tattgcatga aggtactggt cctcgtgtta tttctgcttt tgtggagatt      240

atttttgata attcagacaa ccggttacca atcgataaag aggaagtttc acttcgaaga      300

gttattggtg ccaaaaagga tcagtatttc ttagacaaga agatggtcac gaaaaatgat      360

gtgatgaacc tccttgaaag cgctggtttt tctcgaagca atccttatta tattgttaaa      420

caaggaaaga tcaaccagat ggcaacagca ccagattctc agagattaaa gctattaaga      480

gaagtagctg gtactagagt gtatgacgaa cgaaaggaag aaagcatctc cttaatgaaa      540

gaaacagagg gcaaacggga aaaaatcaat gagttgttaa aatacattga agagagatta      600

catactctag aggaagaaaa ggaagaacta gctcagtatc agaagtggga taaaatgaga      660

cgagccctgg aatataccat ttacaatcag gaacttaacg agactcgtgc caaacttgat      720

gagctttctg ctaagcgaga gactagtgga gaaaaatcca gacaattaag agatgctcag      780

caggatgcaa gagataaaat ggaggatatc gaacgccaag ttagagaatt gaaaacaaaa      840

atttcagcta tgaaagaaga aaaagaacag cttagtgctg aaagacaaga gcagattaag      900

cagaggacta agttggagct taaagccaag gatttacaag atgaactagc aggcaatagt      960

gaacaaagga aacgtttatt aaaagagagg cagaagctgc ttgaaaaaat agaagaaaag     1020

cagaaagaac tggcagaaac agaacccaaa ttcaacagtg tgaaagagaa agaagaacga     1080

ggaattgcta gattggctca agctacccag gaaagaacgg atctttatgc aaagcagggt     1140

cgaggaagcc agtttacatc aaaagaagaa agggataagt ggattaaaaa ggaactcaag     1200

tctttagatc aggctattaa tgacaagaaa agacagattg ctgctataca taaggatttg     1260

gaagacactg aagcaaataa agagaaaaat ctggagcagt ataataaact ggaccaggat     1320

cttaatgaag tcaaagctcg agtagaagaa ctggacagaa aatattacga agtaaaaaat     1380

aagaaagatg aactacaaag tgaaagaaac tacttgtgga gagaagagaa tgcagaacag     1440

caagcacttg ctgctaaaag agaagatctt gaaaagaagc aacaacttct tagagcagca     1500

acaggaaagg ccattttaaa tggaatagac agcataaaca aagtgctaga ccacttccgt     1560

cgaaaaggaa taaaccagca tgttcaaaat ggctatcatg gtattgtaat gaataacttt     1620

gaatgtgaac cagctttcta cacatgcgtg gaagtcactg ctggaaacag gttattttat     1680

cacattgttg attcagatga agtcagcacg aagattttaa tggagtttaa taaaatgaat     1740

cttcctggag aggttacttt tctgcctctt aacaagttag atgtcaggga tacagcctat     1800

cctgaaacca atgatgctat tcctatgatc agcaaactga ggtacaatcc cagatttgac     1860

aaagctttca aacatgtgtt tggaaagact cttatttgtc gtagcatgga agtttcaacc     1920

cagctggccc gtgctttcac tatggactgt attactttgg aaggtgacca agtcagccat     1980

cggggtgctc taactggggg ttattatgac acaaggaagt ctcgacttga attgcaaaaa     2040

gatgttagaa aagcagaaga agaactaggt gaacttgaag caaagctcaa tgaaaacctg     2100

cgcagaaata ttgaaaggat taataatgaa attgatcagt tgatgaacca aatgcaacag     2160

atcgagaccc agcaaaggaa atttaaagca tctagagata gcatattatc agaaatgaag     2220

atgctaaaag agaagaggca gcagtcagag aaaaccttca tgcctaagca acgtagctta     2280

cagagtttgg aggcaagctt gcatgctatg gagtctacca gagagtcatt gaaagcagaa     2340

ctgggaactg atttgctttc tcaactgagt ttggaagatc agaagagagt agatgcactg     2400

aatgatgaga ttcgtcaact tcagcaggaa aacagacagt tgctaaatga aagaattaaa     2460

ttagaaggta ttattactcg agtagagact tatctcaatg agaatctgag aaaacgcttg     2520

gaccaagtag aacaggaact taatgagctg agagagacag aagggggtac tgttctcaca     2580

gccacaacat cagaacttga agccatcaat aaaagagtaa aagacactat ggcacgatca     2640

gaagatttgg acaattccat tgataaaaca gaagctggaa ttaaggagct tcagaagagt     2700

atggagcgct ggaaaaatat ggaaaaagaa catatggatg ctataaatca tgatactaaa     2760

gaactggaaa agatgacaaa tcggcaaggc atgctattga agaagaaaga agagtgtatg     2820

aagaaaattc gagaacttgg atcacttccc caggaagcat ttgaaaagta ccagacactg     2880

agcctcaaac agttgtttcg aaaacttgag cagtgcaaca cagaattaaa gaagtacagc     2940

catgttaaca aaaaggcttt ggatcagttt gtaaatttct ccgagcagaa agaaaagtta     3000

ataaagcgtc aagaagagtt agataggggt tacaaatcaa tcatggaact gatgaatgta     3060

cttgaacttc ggaaatatga agctattcag ttaactttca aacaggtatc taagaacttc     3120

agtgaagtat tccagaagtt agtacctggt ggcaaagcta ctttggtgat gaagaaagga     3180

gatgtggagg gcagtcagtc tcaagatgaa ggagaaggga gtggtgagag tgagaggggt     3240

tctggctcac aaagcagtgt cccatcagtt gaccagttta ctggagttgg aattagggtg     3300

tcatttacag gaaaacaagg tgaaatgaga gaaatgcaac agctttcagg tggacagaaa     3360

tccttggtag cccttgctct gatttttgcc attcagaaat gtgacccggc tccattttac     3420

ttgtttgatg aaattgacca ggctctggat gctcagcaca gaaaggctgt gtcagatatg     3480

attatggaac ttgctgtaca tgctcagttt attacaacta cttttaggcc tgaactgctt     3540

gagtcagctg acaaattcta tggtgtaaag ttcagaaata aggttagtca tattgatgtg     3600

atcacagcag agatggccaa agactttgta gaagatgata ccacacatgg ttaa           3654


<210>  1394
<211>  3276
<212>  DNA
<213>  homo sapiens

<400>  1394
atggccaaaa gaaaggaaga aaatttttcc tctcctaaaa atgccaaaag gccaagacaa       60

gaagaattgg aggattttga taaagatggt gacgaagacg aatgtaaagg tactactttg      120

actgcagcag aagttggaat aattgagagt attcacctaa aaaacttcat gtgtcattca      180

atgcttggac cttttaagtt tggttctaat gtcaactttg ttgttggcaa caatggaagt      240

gggaagagtg cagtactcac agctctcata gtcggtcttg gtggaagagc agttgctact      300

aatagaggat cctctttaaa aggttttgtg aaagatggac agaactctgc agatatctca      360

ataacattga ggaacagagg agatgatgcc tttaaagcca gtgtgtatgg taactctata      420

cttatacagc aacacatcag catagatgga agtcgatctt ataaacttaa aagtgcaaca      480

ggctccgtgg tttccacgag gaaagaagag ctgattgcaa ttcttgatca ttttaacatc      540

caggtggata atccagtttc tgttttaaca caagaaatga gcaagcagtt cttacagtct      600

aaaaatgaag gagacaaata caaattcttc atgaaagcaa cgcaacttga acagatgaag      660

gaagattatt catacattat ggaaacgaaa gaaagaacaa aggagcagat acatcaagga      720

gaagagcggc ttactgaact aaagcgccag tgtgtagaga aagaggaacg ttttcaaagt      780

attgctggtt taagtacaat gaagactaat ttagagtcct tgaaacatga aatggcttgg      840

gcagtggtca atgaaattga aaaacaattg aatgccatca gagataatat caaaattgga      900

gaagatcgtg ctgctagact tgacaggaaa atggaagaac agcaggtcag acttaatgag      960

gcagaacaaa agtacaagga tattcaagac aaactagaaa agattagtga agagacaaat     1020

gcacgagcac cagaatgtat ggcattgaaa gcagatgttg ttgctaagaa aagggcctat     1080

aatgaagctg aggttttata taaccgatcc ttaaacgaat ataaagcatt aaagaaagat     1140

gatgagcagc tttgtaaacg aattgaagag ctgaaaaaaa gtactgacca atctttggaa     1200

cctgaacggt tggaaagaca aaaaaaaata tcttggttaa aagagagagt aaaggccttt     1260

caaaatcaag aaaattcagt caatcaagag atcgaacagt ttcagcaagc catagaaaag     1320

gacaaagaag aacatggcaa aattaagaga gaagaattag atgtgaagca tgcactgagc     1380

tacaatcaga ggcaactgaa agaattgaaa gatagtaaaa ctgatcgact caaaagattt     1440

ggccctaatg ttccagctct tcttgaagcc atagatgatg cttatagaca aggacatttt     1500

acctataaac ctgtaggccc tttaggagct tgcattcatc ttcgggaccc agaacttgct     1560

ttggctattg aatcttgctt aaaagggctt ctgcaggcct attgttgcca taatcatgct     1620

gatgaaaggg tccttcaggc actcatgaaa aggttttatt taccagggac ctcacggcca     1680

ccgataatag tttctgagtt tcggaatgag atatatgatg taagacacag agctgcttat     1740

catccagact ttccaacagt tctgacagct ttagaaatag ataatgcggt tgtggcaaat     1800

agcctaattg acatgagagg catagagaca gtgctactaa tcaaaaataa ttctgtagct     1860

cgtgcagtaa tgcagtccca aaagccaccc aaaaattgta gagaagcttt tactgctgat     1920

ggtgatcaag tttttgcagg acgttattat tcatctgaaa atacaagacc taagttccta     1980

agcagagatg tggattctga aataagtgac ttggagaatg aggttgaaaa taagacggcc     2040

cagatattaa atcttcagca acatttatct gcccttgaaa aagatattaa acacaatgag     2100

gaacttctta aaaggtgcca actacattat aaagaactaa agatgaaaat aagaaaaaat     2160

atttctgaaa ttcgggaact tgagaacata gaagaacacc agtctgtaga tattgcaact     2220

ttggaagatg aagctcagga aaataaaagc aaaatgaaaa tggttgagga acatatggag     2280

caacaaaaag aaaatatgga gcatcttaaa agtctgaaaa tagaagcaga aaataagtat     2340

gatgcaatta aattcaaaat taatcaacta tcggagctag cagacccact taaggatgaa     2400

ttaaaccttg ctgattctga agtggataac caaaaacgag ggaaacgaca ttatgaagaa     2460

aaacaaaaag aacacttgga taccttaaat aaaaagaaac gagaactgga tatgaaagag     2520

aaagaactag aggagaaaat gtcacaagca agacaaatct gcccagagcg tatagaagta     2580

gaaaaatctg catcaattct ggacaaagaa attaatcgat taaggcagaa gatacaggca     2640

gaacatgcta gtcatggaga tcgagaggaa ataatgaggc agtaccaaga agcaagagag     2700

acctatcttg atctggatag taaagtgagg actttaaaaa agtttattaa attactggga     2760

gaaatcatgg agcacagatt caagacatat caacaattta gaaggtgttt gactttacga     2820

tgcaaattat actttgacaa cttactatct cagcgggcct attgtggaaa aatgaatttt     2880

gaccacaaga atgaaactct aagtatatca gttcagcctg gagaaggaaa taaagctgct     2940

ttcaatgaca tgagagcctt gtctggaggt gaacgttctt tctccacagt gtgttttatt     3000

ctttccctgt ggtccatcgc agaatctcct ttcagatgcc tggatgaatt tgatgtctac     3060

atggatatgg ttaataggag aattgccatg gacttgatac tgaagatggc agattcccag     3120

cgttttagac agtttatctt gctcacacct caaagcatga gttcacttcc atccagtaaa     3180

ctgataagaa ttctccgaat gtctgatcct gaaagaggac aaactacatt gcctttcaga     3240

cctgtgactc aagaagaaga tgatgaccaa aggtga                               3276


<210>  1395
<211>  1119
<212>  DNA
<213>  homo sapiens

<400>  1395
atgtcgagga ggagatttga ttgccgaagt atttcaggcc tactaactac aactcctcaa       60

attccaataa aaatggaaaa ctttaataat ttctatatac ttacatctaa agagctaggg      120

agaggaaaat ttgctgtggt tagacaatgt atatcaaaat ctactggcca agaatatgct      180

gcaaaatttc taaaaaagag aagaagagga caggattgtc gagcagaaat tttacacgag      240

attgctgtgc ttgaattggc aaagtcttgt ccccgtgtta ttaatcttca tgaggtctat      300

gaaaatacaa gtgaaatcat tttgatattg gaatatgctg caggtggaga aattttcagc      360

ctgtgtttac ctgagttggc tgaaatggtt tctgaaaatg atgttatcag actcattaaa      420

caaatacttg aaggagttta ttatctacat cagaataaca ttgtacacct tgatttaaag      480

ccacagaata tattactgag cagcatatac cctctcgggg acattaaaat agtagatttt      540

ggaatgtctc gaaaaatagg gcatgcgtgt gaacttcggg aaatcatggg aacaccagaa      600

tatttagctc cagaaatcct gaactatgat cccattacca cagcaacaga tatgtggaat      660

attggtataa tagcatatat gttgttaact cacacatcac catttgtggg agaagataat      720

caagaaacat acctcaatat ttctcaagtt aatgtagatt attcggaaga aactttttca      780

tcagtttcac agctggccac agactttatt cagagccttt tagtaaaaaa tccagagaaa      840

agaccaacag cagagatatg cctttctcat tcttggctac agcagtggga ctttgaaaac      900

ttgtttcacc ctgaagaaac ttccagttcc tctcaaactc aggatcattc tgtaaggtcc      960

tctgaagaca agacttctaa atcctcctgt aatggaacct gtggtgatag agaagacaaa     1020

gagaatatcc cagaggatag cagcatggtt tccaaaagat ttcgtttcga tgactcatta     1080

cccaatcccc atgaacttgt ttcagatttg ctctgttag                            1119


<210>  1396
<211>  1245
<212>  DNA
<213>  homo sapiens

<400>  1396
atgaatctgc aaagatactg gggagagata ccaatatcat caagccagac caacagaagt       60

tccttcgatt tgctcccacg ggagttccgt ctggtggaag tccatgaccc acccctgcac      120

caaccctcag ccaacaagcc gaagcccccc actatgctgg acatcccctc agagccatgt      180

agtctcacca tccatacgat tcagttgatt cagcacaacc gacgtcttcg caaccttatt      240

gccacagctc aggcccagaa tcagcagcag acagaaggtg taaaaactga agagagtgaa      300

cctcttccct cgtgccctgg gtcacctcct ctccctgatg acctcctgcc tttagattgt      360

aagaatccca atgcaccatt ccagatccgg cacagtgacc cagagagtga cttttatcgt      420

gggaaagggg aacctgtgac tgaactcagc tggcactcct gtcggcagct cctctaccag      480

gcagtggcca caatcctggc ccacgcgggc tttgactgtg ctaatgagag tgtcctggag      540

accctaactg atgtggcaca tgagtattgc cttaagttta ccaagttgct gcgttttgct      600

gtggaccggg aggcccggct gggacagact ccttttcctg atgtgatgga gcaggtattc      660

catgaagtgg gtattggcag tgtgctctcc ctccagaagt tctggcagca ccgcatcaag      720

gactatcaca gttacatgct acagattagt aagcaactct ctgaagaata tgaaaggatt      780

gtcaatcctg agaaggccac agaggacgct aaacctgtga agatcaagga ggaacctgtg      840

agcgacatca cttttcctgt cagtgaggag ctggaggctg accttgcttc tggagaccag      900

tcactgccta tgggagtgct tggggctcag agcgaacgct tcccatctaa cctggaggtt      960

gaagcttcac cacaggcttc aagtgcagag gtaaatgctt ctcctctttg gaatctggcc     1020

catgtgaaaa tggagcctca agaaagtgaa gaaggcaatg tctctgggca tggtgtgctg     1080

ggcagtgatg tcttcgagga gcctatgtca ggcatgagtg aagctgggat tcctcagagc     1140

cctgatgact cagatagcag ctatggttcc cactccactg acagcctcat ggggtcctcc     1200

cctgttttca accagcgctg caagaagagg atgaggaaaa tataa                     1245


<210>  1397
<211>  20658
<212>  DNA
<213>  homo sapiens

<400>  1397
atggcatcta gtcctgagct tcccaccgaa gatgaacagg gttcctgggg catcgacgat       60

ctccatattt cattgcaagc tgaacaggaa gacacccaga agaaagcctt cacgtgctgg      120

ataaactcac agttggccag gcacacttct ccctcagtta tatccgacct attcacagac      180

attaaaaagg ggcatgtcct cctggatctg ctagaagtac tttctgggca acagttgcct      240

cgggataaag gatctaatac cttccagtgt agaatcaata tagaacatgc cttgacattc      300

ctaagaaacc gatcaattaa gctaataaat attcatgtta ctgatatcat tgatggaaac      360

ccatccatta tccttggcct aatttggaca attatcctgc actttcatat tgagaagctt      420

gcccagactc tttcttgcaa ttacaatcag ccttccctgg atgatgtgag tgtggttgac      480

tcatctcctg cctcaagtcc tccagctaag aaatgctcta aagtgcaagc aagatggcaa      540

atgtctgcaa gaaaggccct tcttttgtgg gctcaggaac aatgcgccac ctatgagtct      600

gtcaatgtga ccgattttaa gtcaagttgg agaaatggga tggctttttt ggccatcatt      660

catgccttgc gaccagacct aattgacatg aagagtgtga agcatagatc caacaaagac      720

aatctgagag aggccttcag aattgcagaa caagaattaa aaatccccag attgctggaa      780

ccagaagatg tggatgttgt tgatcctgat gaaaagtcca tcatgaccta tgtggcacag      840

tttctgcagt attccaaaga tgcccctggg actggagagg aggctcaggg aaaggtgaaa      900

gatgctatgg gctggttaac tctgcaaaag gaaaaactac agaagttgct aaaggattca      960

gagaatgata cctactttaa aaagtataat agcctgctgt cctttatgga gtcattcaat     1020

gaagaaaaaa agtccttttt ggatgtcctg tcaataaaac gggatctgga tgagctggac     1080

aaggatcatt tacagttgag agaagcctgg gatggcctcg atcaccagat taatgcatgg     1140

aaaataaagc taaattatgc cttgccccca cccctccatc aaactgaagc ttggctccag     1200

gaggtagaag agcttatgga tgaagatttg tcagcctccc aggatcactc tcaagccgtg     1260

actctgatac aagagaaaat gactttattc aagagcctga tggatagatt tgagcatcat     1320

tcgaacattc tccttacctt tgaaaataag gatgaaaatc acttgccatt ggtaccacct     1380

aacaaattgg aggaaatgaa aagacgaatc aacaacattt tggagaaaaa atttattcta     1440

cttctagaat ttcattacta caagtgctta gttcttggtt tggtagatga agtgaaatca     1500

aaattggata tttggaacat taaatatggg agcagagaat ctgtggaatt attgctggaa     1560

gactggcata aatttattga agaaaaagaa ttcctagctc gacttgatac ttcttttcaa     1620

aaatgtggag aaatttataa gaatttggct ggagaatgtc agaatattaa taaacagtat     1680

atgatggtga aatctgatgt ttgtatgtat agaaaaaata tatataatgt gaagtccact     1740

ctacaaaaag tgctggcatg ttgggctact tatgtggaaa accttcgctt actaagggct     1800

tgctttgagg agacaaagaa ggaagaaatt aaagaggtac cctttgagac actagcccag     1860

tggaatctag aacacgctac tttaaatgaa gcaggaaatt tcttagtcga agtcagcaat     1920

gatgtggttg gatcatctat ttctaaagaa ctgagaaggc tgaataaaag atggagaaag     1980

ttggtttcaa aaactcaact tgaaatgaac ctgccactga tgataaaaaa acaggatcag     2040

cccacttttg acaattctgg aaatattcta tctaaagaag agaaagcaac tgttgagttt     2100

tcaacagata tgtcagtaga acttcctgaa aattataatc aaaatataaa ggctggagag     2160

aaacatgaaa aagaaaatga agaattcaca gggcaactaa aagtggctaa agatgttgaa     2220

aaactcattg gacaagtgga aatctgggag gcagaagcca aatctgtttt ggatcaagat     2280

gatgtggaca cctcaatgga agaatctttg aagcatctta ttgccaaagg ctctatgttt     2340

gatgagctta tggcaagaag tgaagatatg ttacaaatgg atatacaaaa tatttcaagc     2400

caggagtcct ttcaacatgt tctcacaact gggcttcagg caaagattca agaagctaaa     2460

gagaaagtcc agatcaatgt ggtaaaactc attgcagcgt tgaagaactt aactgacgtt     2520

tcaccagatt tggacatcag gctgaagatg gaagaatccc agaaggaact tgaatcatat     2580

atgatgaggg ctcagcagtt actggggcaa agagagagcc ccggtgaact catttcaaaa     2640

cacaaggaag cactaataat ttctaataca aaaagtctgg ccaagtattt gaaagctgtt     2700

gaagaactaa aaaataatgt aactgaggac ataaagatgt ctttagaaga aaagagtaga     2760

gatgtctgtg ccaaatggga gtctcttcat catgaactgt ctttatatgt tcaacaacta     2820

aaaatagata ttgaaaaagg aaagcttagt gacaatattt taaaacttga aaagcaaata     2880

aataaagaaa agaaacttat ccgtagagga aggaccaagg gtctcatcaa agaacatgag     2940

gcctgctttt ctgaggaagg ctgcctgtac cagcttaatc accacatgga agtcctgagg     3000

gagctgtgtg aagagctgcc ttcacagaag agtcaacaag aagtgaagag actactcaaa     3060

gattatgaac aaaagataga aagacttctg aaatgtgctt ccgagattca tatgacactg     3120

cagcccacag cgggaggcac gtcgaaaaac gaggggacca tcaccacatc tgagaataga     3180

ggaggggatc cccacagtga ggcaccattt gcaaaatcag ataatcagcc atcaactgaa     3240

aaggcaatgg aacccactat gaagtttagc ctggcatcag tgttaaggcc tctgcaagaa     3300

gaaagcatta tggaaaagga ttacagtgca tctataaata gtttactaga gaggtatgat     3360

acatacagag atattcttga acaccacctg caaaacaaca aattcaggat tacttctgat     3420

ttctctagtg aagaggacag gagtagttct tgtctgcagg ctaaactgac agatctacag     3480

gtcataaaaa atgaaactga tgctcgctgg aaagagtttg aaattatttc attgaagtta     3540

gaaaatcatg tgaatgacat aaaaaagcct tttgtaatta aggaaagaga cacactaaag     3600

gaaagagaaa gagagcttca gatgactctt aataccagaa tggaatcttt agagacagca     3660

ctgcggcttg tgttacctgt agagaaggca tcacttcttc tctgtggctc ggacctgcct     3720

ctccataaaa tggccatcca gggatttcat ctcattgatg ctgatcgcat ctatcaacac     3780

ctaaggaata tccaagattc catagcaaaa cagattgaaa tatgtaaccg cttagaagag     3840

ccaggcaact ttgtattaaa ggagttacac ccatttgatc tacacgcaat gcagaatatt     3900

atactgaaat acaaaacaca atttgaagga atgaaccaca gggtgcagag gagtgaagat     3960

actctcaaag ctctggaaga ctttttggcg tctctcagaa cagctaaact ctctgctgag     4020

cccgttacag acctttcagc ctcagataca caggtggcac aagaaaatac gttgacagta     4080

aaaaataaag agggagaaat tcatctgatg aaagacaagg ccaaacattt ggataaatgt     4140

ttgaagatgc tcgatatgag ctttaaagat gctgaacggg gtgatgacac ctcctgtgaa     4200

aacctgcttg atgctttttc aataaagtta tctgagacac atggctatgg ggtacaggag     4260

gaattcactg aggaaaacaa attactagag gcttgtattt tcaaaaataa tgaactcctt     4320

aaaaatattc aagatgtgca gagtcaaatc agtaaaattg gtcttaagga tcctactgtt     4380

ccagctgtga aacatcggaa aaaatcatta atcagactgg ataaggttct agatgaatat     4440

gaagaagaga agagacattt acaagaaatg gctaattctc ttccacactt caaagatggc     4500

agagaaaaaa ccgtgaatca acagtgccaa aatacagtag tcttgtggga gaataccaaa     4560

gccttggtca ccgaatgtct tgaacaatgt gggagagttt tggagctctt aaaacaatat     4620

cagaatttta aaagcatctt gacaactttg attcaaaaag aagagagtgt catctccctg     4680

caggcttcgt acatgggaaa ggagaacctg aagaaaagga tagcagagat tgaaattgtc     4740

aaagaagaat ttaatgagca tttagaagtt gtagacaaga taaaccaggt ctgcaaaaat     4800

ctacaatttt atctaaataa aatgaaaact tttgaagagc ccccttttga aaaagaggct     4860

aatattattg tggatagatg gcttgatata aatgagaaga cagaagatta ctatgaaaat     4920

cttggtcgag ctctagcttt gtgggacaaa ctttttaact taaaaaatgt cattgatgag     4980

tggacagaaa aggcccttca aaaaatggaa ttacatcaat tgactgaaga ggacagagaa     5040

aggctgaagg aagaattaca agtccatgaa caaaaaactt cagaattttc tagaagagtg     5100

gctgaaatac agtttttgct ccaaagcagt gaaatacctc ttgaattgca ggtcatggag     5160

tcctctattt tgaacaagat ggaacatgta cagaagtgct taacaggaga atccaactgc     5220

catgcactca gtggcagcac tgctgagcta agggaggatc tcgaccaagc caagacccag     5280

atcgggatga ctgaatccct cttaaaagcc ctgtctcctt ctgacagctt ggagatcttc     5340

actaaactag aggagataca acagcagatt ctacagcaaa aacacagtat gatattactt     5400

gagaatcaaa taggttgtct gactcctgaa ctctctgaat tgaaaaagca atatgaaagt     5460

gtcagtgatt tatttaatac caaaaaaagt gttttgcaag atcacttttc taagttattg     5520

aatgatcaat gcaagaactt taatgactgg ttcagcaaca ttaaagtgaa ccttaaggag     5580

tgttttgaat catcagaaac aaaaaagagt gtggaacaaa agctacaaaa actttctgat     5640

ttcttgactc ttgaaggaag aaacagtaaa ataaagcagg tggacagcgt actgaagcat     5700

gtgaagaagc atctgcccaa agcacatgtg aaggagctta tcagttggct cgtgggtcag     5760

gaattcgaat tagaaaaaat ggagtccata tgccaggctc gagcaaagga gcttgaagac     5820

tccttgcagc agctactgag actccaggat gaccatagaa acctgaggaa gtggttgact     5880

aatcaagaag agaaatggaa aggaatggaa gaaccagggg agaaaactga gctgttctgc     5940

caagctttag ctagaaagag ggaacagttt gaatctgtgg cccaattgaa caactctttg     6000

aaggaatatg ggtttactga agaagaagaa ataataatgg aagcaacatg tttgatggat     6060

agataccaga cattactgag acaactaagt gaaatcgagg aagaggataa gttactaccc     6120

acagaggacc agagctttaa tgatcttgca catgatgtaa ttcattggat aaaagagatt     6180

aaagagtccc ttatggtttt gaattcatcc gaaggcaaaa tgccacttga ggaaagaatc     6240

caaaaaatca aggaaatcat tttgctgaag cctgaagggg atgccagaat agagaccatc     6300

atgaagcagg ctgagagcag cgaggccccg ctggttcaga agaccctcac tgacatcagc     6360

aaccagtggg acaacacact ccatttagct agcacctacc taagccatca agaaaagctt     6420

ctactagaag gagagaaata tttacaaagt aaggaggatc tgagattaat gctcatagaa     6480

ctaaagaaga aacaggaagc aggctttgct ctacaacatg gtctgcagga gaagaaagct     6540

cagttaaaga tttataagaa attcctcaag aaagcccaag atttgacatc cttgctaaag     6600

gagttaaaat ctcagggaaa ctacctcttg gagtgcacta aaaatcccag cttcagtgaa     6660

gagccttggc tggaaataaa gcatctacac gaaagtcttc ttcaacaact gcaggattct     6720

gtgcaaaact tggacggtca cgttcgagaa catgattcat accaggtttg cgtcacagac     6780

ctgaatacta cattggacaa tttctccaag gaatttgtca gtttttctga taagcctgtg     6840

gatcaaatag cggttgagga aaaattgcag aaactgcagg aactagagaa tagactcagt     6900

ttacaagatg gcacattaaa gaagatttta gctttagcaa aatccgtcaa gcaaaataca     6960

tcttcagtgg ggcagaagat tattaaagat gatataaaat cacttcagtg taaacaaaaa     7020

gatttggaaa acaggcttgc atctgctaag caggagatgg aatgttgtct caacagcatt     7080

ctcaaatcaa aacgctcaac agaaaagaaa ggaaagttta ctctgccagg cagagagaag     7140

caggccactt ctgatgtgca ggagtctact caggaatcag ctgcagtgga aaagttggag     7200

gaagactggg aaataaacaa ggattcagct gtggaaatgg ctatgtcaaa acaactttct     7260

cttaatgctc aagaaagcat gaaaaacact gaagatgagc ggaaagtcaa tgagctgcaa     7320

aatcaacctt tagaattaga tactatgtta agaaatgaac aattagaaga gatagagaaa     7380

ttatataccc agttggaagc aaagaaagca gccattaagc cactggaaca aacagaatgt     7440

cttaacaaaa cagaaactgg ggccttggtt ctccacaata taggatattc ggcacagcat     7500

ttggacaatt tgcttcaggc acttattact ttgaagaaaa acaaagaaag ccaatattgt     7560

gtcctcagag attttcagga ataccttgct gcagttgaat cttcaatgaa agccttgttg     7620

acagacaagg aaagtcttaa agtaggacca ctggacagtg taacgtatct ggacaaaatt     7680

aaaaaattca tagcatccat agaaaaagag aaagattctt taggcaactt gaaaatcaaa     7740

tgggagaatt tatcaaacca cgtgactgac atggataaga aattgttgga aagccagatt     7800

aagcaacttg aacatggttg ggaacaagtg gaacagcaga ttcaaaagaa gtattctcag     7860

caggtagtgg aatatgatga atttacaacc ctcatgaata aggtacagga cactgagatt     7920

tctctgcaac agcagcagca acatctacag ttaaggctga agtctccaga agaacgggca     7980

gggaaccaaa gcatgattgc cttgaccact gacctccagg ctaccaagca tggattttct     8040

gttttaaagg ggcaagctga acttcagatg aagaggattt ggggagaaaa agaaaagaag     8100

aatttggagg atggaataaa taacttgaag aaacaatggg aaacattgga gccattacac     8160

ttagaagcag aaaatcagat taagaagtgt gacataagga acaagatgaa agagactatc     8220

ttatgggcca agaatttgtt gggtgaactt aatccctcca ttccccttct cccagatgac     8280

attctttcac agatcagaaa gtgcaaagtg acacatgatg gcattctagc taggcagcag     8340

tctgtggaat cgttggctga agaggtcaaa gataaggttc ctagccttac aacctatgag     8400

ggcagtgatt taaataatac cctagaggac ttacggaatc aataccaaat gctggtttta     8460

aaatcaactc aaagatcaca gcaattagaa tttaagttgg aagaaagaag caattttttt     8520

gctataataa ggaagtttca acttatggtt caagaaagtg aaacactgat aattcccagg     8580

gtggagacag ctgccacgga agctgaacta aaacatcacc atgttacttt ggaggcatct     8640

cagaaggaat tgcaagaaat tgacagtgga atctcaacac atcttcagga gctaacaaac     8700

atctatgagg agctgaatgt gtttgaaaga ttatttctgg aagatcagtt gaaaaatctt     8760

aagattagga ccaacagaat acaaagattc attcagaata catgtaatga agtggaacac     8820

aagataaagt tttgcagaca attccatgaa aaaacatcag cgcttcagga ggaggctgac     8880

agtatacagc gcaatgaact attacttaat caagaagtaa ataaaggtgt taaagaggag     8940

atctataatc ttaaagacag actcaccgct attaagtgtt gcatcttaca ggtattgaaa     9000

cttaaaaaag tgtttgacta tattggacta aactgggatt tttcacaact tgaccaatta     9060

caaacccaag tatttgaaaa agaaaaggaa cttgaagaaa aaattaagca gttggacaca     9120

tttgaggaag aacatggcaa atatcaggca ttattaagta aaatgagagc tattgatttg     9180

caaattaaga aaatgactga agtagtacta aaagctcctg atagctctcc ggaaagcaga     9240

cggctcaatg cccaaatttt aagtcagaga attgagaaag ccaagtgttt atgtgatgag     9300

ataataaaga aattaaatga aaataagacc tttgatgact cattcaagga gaaagaaata     9360

ctacaaataa agctgaatgc agaagaaaat gataagttat acaaagttct ccaaaacatg     9420

gtattagaac tctcaccaaa agaattggat gaaaagaatt gtcaggacaa actagaaact     9480

tccttacatg ttttaaatca gataaaatct caattacagc agccattact tataaatttg     9540

gaaattaaac atattcaaaa tgaaaaggac aattgtgaag catttcagga gcaagtttgg     9600

gcagaaatgt gtagtattaa agctgtgact gctattgaga aacaaagaga agaaaactct     9660

tctgaagcga gtgatgtgga gacaaaacta cgtgagtttg aagatcttca gatgcagctt     9720

aacacaagca ttgatttgcg cacaaatgtc ttgaatgatg cttatgaaaa tctaacacgc     9780

tataaagaag cagtcaccag ggcagtggag agcatcactt ccctcgaagc catcattata     9840

ccctacagag tagatgttgg taatccagaa gaatctttag agatgcctct tcgaaaacaa     9900

gaggaattgg aatccacagt agcacacatc caggacctca ctgagaaact gggaatgata     9960

tccagccccg aagccaaact acaacttcag tatactttac aggaactagt ttctaagaac    10020

tcagcaatga aggaagcttt caaagcacag gaaactgagg cagaaaggta tcttgagaat    10080

tacaaatgct atagaaaaat ggaagaggat atttacacta acctcagcaa aatggagaca    10140

gttcttggac agtccatgtc ctcgttgcca ctgtcttaca gagaagcttt agagcgcttg    10200

gaacagagca aggccttggt gtcaaatctt atatcaacca aagaagagtt aatgaaacta    10260

cgacagatcc ttagactctt gagactcagg tgcacagaaa atgatggcat atgtttgctc    10320

aagattgtgt cggctctgtg ggagaaatgg ctgagtttgc tggaagctgc taaagagtgg    10380

gagatgtggt gcgaagaact gaagcaggaa tggaaatttg tcagtgaaga aattgaacga    10440

gaggcaatta ttttagataa tcttcaggaa gaactccctg aaatttccaa aacaaaagag    10500

gcagccacca cagaggaact ctctgagctg ctagactgtt tatgccaata tggagagaac    10560

gtggagaagc aacagctgtt actgactcta cttcttcagc gcatcagaag tatccagaat    10620

gttcctgaaa gctcaggggc tgtggaaact gttccagcat ttcaagaaat tacttctatg    10680

aaagaacgat gcaacaagct tcttcagaaa gttcagaaaa ataaagaatt ggtgcagact    10740

gaaatccaag aaagacattc cttcacaaaa gagataattg ctttgaagaa tttctttcaa    10800

cagaccacaa cttcattcca aaatatggca ttccaggatc acccagaaaa gtcagaacaa    10860

tttgaggagc ttcaaagcat ccttaagaaa gggaaactaa cttttgagaa tattatggaa    10920

aaactgcgaa tcaagtattc cgaaatgtac accatagtcc ctgcagagat tgaatcccag    10980

gtggaagaat gcagaaaagc tttagaagac atagatgaga agattagcaa tgaagtctta    11040

aaaagctcac catcatatgc aatgaggaga aaaatagaag aaattaacaa tgggcttcat    11100

aatgttgaaa agatgttgca gcagaaaagc aaaaatattg agaaagctca agaaattcaa    11160

aagaaaatgt gggacgagtt agatctatgg cattccaaac taaatgagct ggattctgaa    11220

gttcaggaca ttgttgaaca ggacccagga caggctcaag aatggatgga taacttgatg    11280

attcctttcc agcagtatca gcaagtatca cagagagcag agtgtagaac ctcacagttg    11340

aataaggcca cagttaagat ggaggaatat agtgaccttc tgaagagcac tgaggcttgg    11400

atagaaaata ccagtcattt gctggccaat cctgctgact atgactcttt gaggacactg    11460

agtcaccatg ctagcactgt gcagatggct ttggaagatt cagaacagaa gcacaatctt    11520

ttacattcaa tctttatgga tctagaagac ctgtcaataa tttttgaaac agatgaatta    11580

acccaatcca tacaagagtt aagtaatcaa gtaacagctt tacaacaaaa aataatggaa    11640

agccttccac agattcagcg aatggctgat gatgtggttg ctattgaatc tgaagtaaaa    11700

tcaatggaaa aaagagtttc aaaaatcaaa actatcctat tatcaaaaga aatatttgat    11760

ttttcacctg aagaacatct caaacatggg gaggtcatac ttgaaaatat acgtcccatg    11820

aagaaaacca ttgctgagat agtgtcttac caagtggaac tgaggttgcc ccaaacagga    11880

atgaaacctc tgcctgtgtt tcagcggaca aatcagcttt tacaagatat aaaactattg    11940

gaaaatgtga ctcaagaaca aaatgagtta ttaaaggtag tcataaaaca gaccaatgaa    12000

tgggatgaag aaatagaaaa tttgaaacag atcttaaata attattcagc tcagttctcc    12060

cttgaacata tgtcaccaga ccaagctgac aagctgccac aactacaggg agaaatcgaa    12120

cgtatggaga aacagattct gagtttgaac cagagaaaag aagacctgtt ggtggacttg    12180

aaggccaccg tactaaacct tcaccagcat ttgaagcaag aacaagaagg agtagaaaga    12240

gataggctgc cagctgtaac atcagaggaa ggtggagtgg cagagaggga tgcttctgag    12300

cggaagttga acagaagagg ctccatgtct tacctggcag cagtcgagga agaggtggaa    12360

gaaagttccg tgaagagcga taatggagat gagaaggcag agccatcgcc tcagtcttgg    12420

tcttcacttt ggaagcatga caaggacatg gaagaagaca gagcttcctc atcctctgga    12480

acaattgttc aggaagcata tgggaaaata agcacctctg ataattccat ggcacaaatc    12540

ctcacaccag actcactaaa cactgagcaa ggcccagaat gttccctaag gcccaaccaa    12600

acagaagagg gcaccacacc tcctattgag gctgacactc tggactcttc tgacgcgcaa    12660

ggaggtttgg agcccagggt ggagaaaact aggccggagc ccacagaagt cctgcatgcc    12720

tgcaagaccc aggtggccga gctggagctg tggctgcaac aagccaacgt ggcagttgag    12780

ccggaaacat taaacgcaga catgcagcag gtgctggaac agcagctggt agggtgccag    12840

gctatgctaa cagagattga gcacaaggtt gcctttctgt tagagacttg caaagatcag    12900

ggcctgggag ataatggagc cactcaacat gaggctgaag cgctttccct gaaactgaaa    12960

acagtgaagt gcaatttaga aaaagtccag atgatgcttc aggagaagca cagtgaagat    13020

cagcatccta ccattctaaa gaaatcctca gagccagagc atcaagaagc tctccaacca    13080

gttaaccttt ctgaattgga atccattgta actgaaaggc cacaattcag cagacaaaaa    13140

gatttccagc agcaacaggt tctggagtta aaaccaatgg aacagaaaga tttcatcaaa    13200

ttcatagaat ttaatgctaa gaaaatgtgg ccccagtatt gccaacatga taacgataca    13260

actcaggaat catctgcaag caaccaggca tccagccctg aaaatgacgt tccagactcg    13320

atcttgtcac cccagggcca aaatggagat aagtggcaat atctgcatca tgaactctca    13380

tcaaaaataa agctcccact ccctcagctt gtggagcctc aggtttccac aaatatgggt    13440

attctaccca gcgtgactat gtataacttt agatacccaa caactgaaga actgaaaacc    13500

tataccaccc aacttgaaga cctgcgccaa gaagcaagta accttcagac acaggaaaat    13560

atgacagaag aagcatatat caatttggat aaaaaattgt ttgaactatt cctgaccctc    13620

agtcagtgcc tcagcagtgt ggaggagatg ctggagatgc ccagacttta cagggaggat    13680

ggttctggcc agcaggtgca ctacgagacg ctggctcttg agttgaagaa actttattta    13740

gcgctaagtg acaagaaggg tgatcttttg aaagccatga cttggcctgg cgagaacacc    13800

aacttgctcc ttgaatgttt tgacaacctt caagtctgcc tggagcacac tcaggctgca    13860

gctgtctgta gaagcaagtc cctgaaagct ggcctcgatt acaaccgcag ttaccagaat    13920

gaaataaaga gattatatca tcagctcatt aagagtaaga catctttaca acagtctttg    13980

aatgaaatca gtgggcagag tgttgctgaa cagcttcaga aagcagatgc atatacagtg    14040

gagctggaga acgccgagag ccgagtggcc aaactaagag atgaagggga gaggcttcat    14100

ttaccttatg ctttactcca ggaggtttac aaattagagg atgtacttga cagtatgtgg    14160

ggaatgctaa gagccaggta cacagaactc agcagccctt tcgtcactga gagccagcaa    14220

gatgctttgt tgcaaggcat ggtggaactg gtgaagattg ggaaggaaaa gcttgctcat    14280

ggccacttaa aacaaaccaa aagtaaagtg gcgttacagg ctcaaataga aaatcacaag    14340

gtttttttcc agaagcttgt tgctgacatg ttgttgatcc aagcatactc tgccaaaata    14400

cttccttctt tattgcaaaa cagagagaca ttttgggcag aacaagtaac agaagttaaa    14460

atactagaag aaaagtcacg ccaatgtggt atgaagctgc agagtttgtt gcagaaatgg    14520

gaagaatttg atgaaaacta tgcatctctt gaaaaggacc tggaaattct tatatctaca    14580

ttgccctctg tgagtttggt ggaagaaaca gaggaaagat tagtggaaag gatttcattt    14640

taccagcaaa taaaaagaaa cattggtgga aaacacgccc ggctttacca aactctgaac    14700

gaaggcaaac agttggtggc gtctgtgagc tgtcctgaat tagagggcca gatcgcaaaa    14760

ctggaagagc agtggttgtc cctgaacaag aaaattgacc atgagctcca caggctgcaa    14820

gctcttctca agcatctgct cagttataac agagattcgg atcagttaac caagtggttg    14880

gaatcttccc agcatactct gaattactgg aaagaacagt ccctcaatgt gtctcaggac    14940

ttggatacaa tcagaagcaa catcaacaat ttttttgagt tttcaaaaga agttgatgaa    15000

aaatcctcct tgaagactgc cgttatcagt atcgggaacc agcttcttca cctgaaagaa    15060

actgatacag ctacactgag agcttcttta gcacagtttg aacaaaaatg gacaatgctc    15120

ataactcaac ttccagatat tcaagaaaaa cttcaccagc ttcaaatgga gaaattgccg    15180

tctcgtaaag caatcacaga aatgattagc tggatgaaca atgtggagca tcaaacttca    15240

gatgaagact ccgtgcattc accaagttct gcatctcaag ttaaacatct tcttcagaag    15300

cacaaggagt ttagaatgga aatggactat aaacagtgga tagttgactt cgttaaccag    15360

tcattacttc agctaagcac ctgtgatgta gaaagcaagc gctatgaaag aacggagttt    15420

gcagagcacc tgggggagat gaaccgccag tggcaccgtg tacatggaat gctgaataga    15480

aagatacaac atttagaaca acttctagaa agtatcactg agagtgaaaa taaaatacag    15540

atcttgaaca actggctgga agcacaagaa gagagactga aaactttaca aaaacctgaa    15600

agtgtgatct cagtgcagaa gctgctcctg gactgtcagg atatagaaaa tcaacttgca    15660

attaaatcca aagcactaga tgagttgaaa caaagttatc tgactttgga gagtggggca    15720

gtgccattgt tagaagatac agcatcccga attgatgagt tatttcaaaa gagaagcagt    15780

gttctcactc aggtcaatca gctcaaaacc tccatgcagt cagttttaca ggagtggaag    15840

atttatgatc aactctatga tgaagtgaat atgatgacaa tccgattctg gtactgcatg    15900

gaacacagca agcctgtggt gttatcattg gagaccttga gatgccaggt ggagaacctt    15960

cagtctctgc aagatgaagc tgagagcagt gaagggagtt gggagaaact ccaggaggtt    16020

atcggcaaac tcaaaggtct ctgcccctct gttgctgaaa taatcgaaga gaaatgccaa    16080

aatactcata aaaggtggac tcaggtgaac caagccattg cagaccagtt gcagaaggcc    16140

cagagtctgc tccagctctg gaaggcctat agcaatgctc atggtgaagc tgccgcaagg    16200

ctgaagcagc aggaagcaaa gtttcaacag ctcgcaaaca tcagcatgtc tggaaacaac    16260

ctggcagaga tcctgccccc agccctgcag gacataaagg agctgcagca tgatgtgcag    16320

aaaacaaaag aagcctttct ccaaaattcc agtgtcctgg atcgactccc acaacccgca    16380

gagtccagca cccacatgct cctcccgggc cccctgcact ctctccagag ggctgcttat    16440

ttggaaaaga tgctgcttgt gaaagcaaat gaatttgagt ttgttctctc acagtttaag    16500

gattttggag tccggctgga atctttaaaa ggtcttatta tgcatgaaga agagaatttg    16560

gatagacttc accaacagga aaaagaaaat cctgactcat tcctgaatca tgtgctggca    16620

ctgacagccc aatcacctga tattgaacat ttgaatgaag tgagcctcaa gctcccactt    16680

agtgacgtag ctgtgaagac gttacaaaat atgaaccggc aatggattcg ggccacggcc    16740

acggcactgg agcgctgcag tgagcttcag ggaattggat tgaatgaaaa gtttctttat    16800

tgctgtgaaa agtggatcca acttttggag aagatagaag aagcactcaa agtggatgtg    16860

gctaacagcc ttcctgagct cctggagcag cagaaaacct ataagatgtt agaagctgaa    16920

gtttctataa accagacaat tgctgattcc tatgtcaccc agtccttaca actcctggac    16980

acaacagaaa tagagaacag accagaattt attacagaat tctcaaagct gacggatcgg    17040

tggcagaatg ctgtccaggg tgttcggcag aggaagggtg acgttgatgg gctggtgagg    17100

cagtggcaag atttcactac ttctgtggag aacttgtttc gcttcctcac tgacaccagc    17160

cacctgctat ctgcagtgaa gggccaggag cgcttcagcc tctaccaaac cagaagtctg    17220

atccatgagc tgaagaataa agaaattcat tttcaaagga ggcgaactac ctgtgcccta    17280

accttggaag ctggagaaaa gttactgctc acaactgacc tgaaaactaa agagtctgtg    17340

ggtaggagaa tcagtcaact tcaggacagc tggaaagaca tggagcccca gctggcagag    17400

atgattaagc agttccagag cactgtagag acctgggacc agtgtgaaaa gaaaatcaag    17460

gagttgaaaa gcaggctgca agttttaaag gcacaaagtg aagatcctct tccagagctt    17520

cacgaggacc tccataacga aaaagagctg attaaggaac tagaacagtc tttggctagc    17580

tggactcaga acttgaaaga acttcaaact atgaaggcgg acttaacccg gcacgttctc    17640

gtggaagatg tgatggtttt gaaggagcaa atagagcatt tgcacagaca atgggaggac    17700

ctctgcttaa gggtggccat acgtaaacag gagattgaag acagactcaa tacatgggtt    17760

gtattcaatg aaaaaaataa agagttgtgt gcctggctgg tgcagatgga aaacaaagtt    17820

ctacagacag cggacattag tattgaagaa atgattgaaa agttacagaa ggactgcatg    17880

gaagaaataa acttgtttag tgaaaacaag ttacagttaa agcagatggg tgaccagttg    17940

atcaaggcca gcaacaaatc aagagcagct gagatcgatg acaagctcaa caaaattaac    18000

gatcgttggc aacatctttt tgatgtcatc ggatcaaggg tgaagaagct gaaggagacc    18060

tttgctttta ttcagcagtt ggacaaaaac atgagcaacc ttcgcacctg gttggctcga    18120

attgagtctg agctttccaa gcctgttgtt tatgatgtct gcgatgatca agagatccag    18180

aagaggctcg ctgagcagca ggatctacag cgagatattg aacaacacag cgcaggggtg    18240

gagtccgtgt ttaacatctg tgacgtccta ctgcacgact ccgatgcctg tgcaaatgag    18300

accgagtgtg actcgatcca gcagaccacc aggagcctgg acagacgctg gaggaacatt    18360

tgtgccatgt ccatggagcg gcgcatgaaa atcgaggaga cgtggcgcct gtggcagaag    18420

tttttagacg actattctcg ctttgaggac tggctcaagt cagctgagag gacggcagcc    18480

tgcccaaatt cctcagaggt gttgtacacg agtgccaaag aggaactgaa gaggtttgag    18540

gcctttcagc ggcagattca tgagcggctc actcagctgg agctcatcaa caagcagtac    18600

cggcggctgg cccgggagaa ccgcacagac acggccagca ggctgaagca gatggtccac    18660

gagggcaacc agcgctggga caaccttcag aggcgggtca cagccgtcct gcggagactc    18720

aggcatttca ccaaccagag ggaagaattt gagggcacca gggagagcat tctggtgtgg    18780

ctcacagaga tggacctgca gctgaccaac gtggagcact tctcagagag tgacgccgat    18840

gacaagatgc gccaactgaa tggcttccaa caggaaatta cattaaatac caacaagatt    18900

gatcagctca ttgtgtttgg ggagcagctg attcagaaga gcgagcccct ggatgctgtg    18960

ctgattgagg atgagctgga ggaactccac cgctactgcc aggaggtgtt tggaagggtc    19020

tcccggttcc accggcggct cacctcctgc actccgggct tggaagatga aaaggaggcc    19080

tctgagaatg aaacagacat ggaagacccc agagaaatcc agactgattc ttggcgtaaa    19140

cggggagaga gcgaggaacc gtcatctcct cagtccctgt gtcatctagt ggccccaggg    19200

cacgagcggt ctggctgcga gacccctgtc agcgtggact ccatccccct ggagtgggac    19260

cacacaggcg acgtgggggg ctcctcctct cacgaagagg acgaggaggg cccatactac    19320

agcgcactgt caggtaaatc catttcggat ggccactcgt ggcatgttcc cgacagccct    19380

tcctgtcccg agcatcacta caagcaaatg gaaggtgaca ggaatgttcc acctgttccc    19440

cctgcgtcca gcacccctta taaaccaccc tatggaaagc tactattacc tccaggcacg    19500

gatggtggca aagaaggccc gcgagtcctg aatggcaacc cacagcagga agacggggga    19560

ctggccggta tcacagagca gcagtcaggt gccttcgaca gatgggagat gattcaagca    19620

caggagcttc acaataagct caaaataaaa caaaatttgc aacagctgaa ctctgatatc    19680

agcgccatca ctacttggct gaaaaaaact gaagcagagc tggaaatgtt aaagatggca    19740

aagcctccct ctgatatcca ggaaatagaa ctgagagtga agagactgca ggagatactg    19800

aaagcctttg acacttacaa ggcattagtg gtctctgtca acgtgagcag caaggaattt    19860

ctgcaaaccg agagccccga atccacagag ctccaaagta gactccgcca gctgagcctg    19920

ctctgggaag cagcacaggg cgcagtggac agctggagag ggggcttacg acagtcgctc    19980

atgcagtgcc aggacttcca ccagttgagt caaaatctgc tgctgtggtt agcgagtgcc    20040

aagaaccgga ggcagaaggc tcatgtcacc gatccaaagg cagacccccg ggctctccta    20100

gagtgtcgga gggaactaat gcaactggaa aaggagctgg tagaacgtca acctcaagtg    20160

gacatgttac aggagatttc aaacagcctt ctcattaagg gacatggaga agactgtatt    20220

gaagctgaag aaaaggtgca tgttattgag aagaaactca aacagttacg ggagcaagtg    20280

tcccaagatt taatggcctt gcagggaacc cagaacccag cctcacccct gcccagcttc    20340

gacgaggtag actcggggga ccagcctcct gcaacatccg tgccagctcc ccgagcaaag    20400

cagttcagag cagtgagaac tacagaaggc gaggaggaga cagagagcag ggtccccggc    20460

agcacacggc cacagcgctc cttcctctca agggtggtcc gggcagccct acccctgcag    20520

ctgctcctcc tgctgctgct gctcctggcc tgcctgctgc cctcctccga agaagactac    20580

agctgcactc aggccaacaa ctttgcccgg tccttttacc ccatgctgag gtacaccaat    20640

gggccacccc ccacatag                                                  20658


<210>  1398
<211>  1296
<212>  DNA
<213>  homo sapiens

<400>  1398
atggctgaga tcaccaatat ccgacctagc tttgatgtgt caccggtggt ggccggcctc       60

atcggggcct ctgtgctggt ggtgtgtgtc tcggtgaccg tctttgtctg gtcatgctgc      120

caccagcagg cagagaagaa gcagaagaac ccaccataca agtttattca catgctcaaa      180

ggcatcagca tatacccaga gaccctcagc aacaagaaga aaatcatcaa agtgcggaga      240

gacaaagatg gtcctgggag ggaaggtgga cgtaggaacc tgttggtgga cgcagcagag      300

gctggcctgc taagccgaga caaagatccc agggggccta gctctggatc ttgtatagac      360

caattaccca tcaaaatgga ctatggggaa gaactaagga gccctattac aagcctgacc      420

cctggggaga gcaaaaccac ctctccatca tctccagagg aggatgtcat gctaggatcc      480

ctcaccttct cagtggacta taacttcccg aaaaaagccc tggtggtgac aatccaggag      540

gcccatgggc tgccagtgat ggatgaccag acccagggat ctgaccccta catcaaaatg      600

accatccttc ctgacaaacg gcatcgggtg aagaccagag tgctgcggaa gaccctggac      660

cctgtgtttg acgagacctt caccttctat ggcatcccct acagccagct gcaggacctg      720

gtgctgcact tccttgtcct cagctttgac cgcttctctc gggatgatgt cattggcgag      780

gtcatggtgc cactggcagg ggtggacccc agcacaggca aggtacaact gaccagggac      840

atcatcaaaa ggaatatcca gaagtgcatc agcagagggg agctccaggt gtctctgtca      900

tatcagcctg tggcacagag aatgacagtg gtggtcctca aagccagaca cttgccgaag      960

atggatatca ccggtctctc aggtaatcct tatgtcaagg tgaacgtcta ctacggcaga     1020

aagcgcattg ccaagaagaa aacccatgtg aagaagtgca ctttgaaccc catcttcaat     1080

gaatctttca tctacgacat ccccactgac ctcctgcctg atatcagcat cgagttcctc     1140

gttatcgact tcgatcgcac caccaagaat gaggtggtgg ggaggctgat cctgggggca     1200

cacagtgtca cagccagtgg tgctgaacac tggagagagg tctgcgagag cccccgcaag     1260

cctgtggcca agtggcacag tctgagcgag tactaa                               1296


<210>  1399
<211>  1584
<212>  DNA
<213>  homo sapiens

<400>  1399
atgagtgaca ctttgacagc ggatgtcatt ggtcgaagag ttgaagttaa tggagaacat       60

gcaacagtac gttttgctgg tgttgtccct cccgtggcag gaccctggtt aggagtagaa      120

tgggacaatc ccgagagagg aaagcatgat gggagccacg aagggactgt gtattttaaa      180

tgcaggcacc cgacaggagg atcctttatt cgtccgaaca aggtaaattt tggaacagac      240

tttcttactg caattaagaa ccgctatgtg ttagaagatg gaccagagga agatagaaaa      300

gagcaaattg ttacaattgg aaataaacct gtggagacta tcggttttga ctctattatg      360

aaacagcaaa gtcagctgag caagttgcaa gaagtttctc tgaggaactg tgcagtaagt      420

tgtgctggtg aaaaaggagg agttgctgaa gcatgtccta atatcagaaa ggtagatttg      480

tcaaaaaacc tgttgtcatc atgggatgaa gtgatacaca ttgctgatca gctcagacac      540

ctggaagtcc ttaatgtcag tgaaaataaa ctaaaatttc cctccggttc agtattaact      600

ggaacgcttt ctgtactgaa ggttttagtc ctcaatcaaa caggaataac gtgggctgag      660

gtgctgcggt gtgtcgcggg gtgcccaggc ctggaggaac tctaccttga gtctaacaac      720

attttcattt ccgaaaggcc aacagatgtt ctccagacag tcaagttatt agatctttcc      780

tctaatcaat taattgatga aaatcagctg tatctgatag cccacctgcc caggttagaa      840

caattaatcc tctctgacac tggaatttct tctctacatt ttccggatgc tggaattggg      900

tgcaaaacgt ccatgttccc atccttgaag tacctggtag taaacgacaa tcagatatca      960

caatggtcgt ttttcaatga gctagagaag ttaccaagtc tacgggcttt gtcctgccta     1020

agaaaccccc tgaccaaaga ggacaaagaa gcagagacgg cgcgactact cattatcgcc     1080

agcattggcc agctgaagac gctgaacaaa tgtgagattc tccccgagga gaggcggaga     1140

gctgagcttg actaccgaaa agcttttgga aatgagtgga aacaggctgg tggacataag     1200

gatccggaaa aaaacagact cagcgaagaa ttcctcacag cccatcccag ataccagttc     1260

ctctgcctga aatatggtgc acctgaagat tgggaactca aaacacagca accacttatg     1320

ctgaaaaacc agctactaac actgaagata aaataccctc atcaacttga tcagaaagtc     1380

ctggagaaac aactgccggg ctccatgaca attcaaaagg tgaagggatt gctgtcacgt     1440

cttctcaaag ttcctgtgtc agaccttctg ttgtcctatg aaagtcccaa aaagccgggc     1500

agagaaatcg agctggaaaa tgacctaaag tcattacagt tttattctgt ggaaaatgga     1560

gattgtctat tagtgcgatg gtga                                            1584


<210>  1400
<211>  2049
<212>  DNA
<213>  homo sapiens

<400>  1400
atgaatcccc agcaacaacg catggccgct atagggaccg acaaggagct gagcgaccta       60

ctggacttca gtgcgatgtt ttccccacct gttaatagtg ggaaaactag accaactaca      120

ctgggaagca gtcaattcag tggatcaggt attgatgaaa gaggaggtac aacatcttgg      180

ggaacaagtg gtcaaccaag tccttcctat gattcatcta gaggttttac agacagccct      240

cattacagtg atcacttgaa tgacagtcga ttaggagccc atgaaggctt gtccccaaca      300

cctttcatga actcaaatct gatgggaaaa acatcagaga gaggctcatt ttccctgtac      360

agcagagata ctggattacc aggctgtcaa tctagtctcc tgagacaaga tctggggctt      420

gggagcccag cacagctatc ttcttcagga aaacctggga cagcatacta ttcattctct      480

gctacaagtt ccaggaggag accactccat gactctgcag cgcttgatcc cttgcaagca      540

aaaaaagtca gaaaggtgcc tcctggtttg ccttcttctg tatatgcacc atccccaaat      600

tcagatgatt tcaaccgtga atctcctagt tatccatctc ctaagccacc aaccagtatg      660

ttcgctagca ctttctttat gcaagatggg acccacaatt cttctgacct ttggagttca      720

tcaaatggga tgagccagcc tggttttggt ggaattctgg ggacctccac ttcccacatg      780

tctcaatcca gtagttatgg caaccttcat tcacatgacc gcttgagtta tcctccacac      840

tcagtttcac caacagacat aaacacgagt cttccaccaa tgtccagctt tcatcgcggc      900

agtaccagca gttcacctta cgttgctgcc tcacacactc ctcccatcaa tggatcagac      960

agcattctag gaaccagagg gaatgctgct ggaagctcac agacaggtga tgcacttgga     1020

aaggctttgg catctattta ttctcctgac cataccagca gtagttttcc gtcaaatcca     1080

tcaacaccag ttggatcacc ttcacctctc acaggtacca gtcagtggcc aagacctgga     1140

gggcaagcac cttcatcccc aagctatgaa aactcactcc actccctgca gtctcgaatg     1200

gaggatcgtt tagacagact ggatgatgca atccatgtgc tgcggaacca tgctgtggga     1260

ccttccacca gtttgcctgc tggtcacagt gatatacata gtttattggg accatcccat     1320

aatgcaccaa ttggaagcct caattcaaac tatggaggat caagccttgt tgcaagcagt     1380

cgatcagctt caatggttgg aactcatcgg gaagactctg tcagtctcaa tggcaatcat     1440

tcagtcctgt ctagtacagt cactacttca agcacagacc tgaaccataa aacacaagaa     1500

aattatagag gtggcttgca aagtcagtct ggaactgttg ttacaacaga aatcaagact     1560

gaaaacaaag aaaaggatga aaaccttcat gaacctcctt catcagatga catgaagtca     1620

gatgatgaat cctcccaaaa agatatcaag gtttcatcta gaggcagaac aagcagtact     1680

aatgaagatg aggatttgaa ccctgaacag aagatagaaa gggagaagga gaggcggatg     1740

gctaacaatg ccagagaacg cttacgcgtg cgggatatta atgaagcatt caaagagctt     1800

ggccgaatgt gtcagcttca cttgaagagt gaaaaacccc aaacaaaact ccttattctt     1860

catcaagccg tggcagtcat ccttagtcta gaacagcaag tcagagagag gaaccttaac     1920

cccaaagcag cctgccttaa gagaagggaa gaagaaaaag tttctgccgt atcggcagag     1980

ccgccaacca cactgccagg aacccatcct gggcttagtg aaactaccaa ccctatgggt     2040

catatgtaa                                                             2049


<210>  1401
<211>  1791
<212>  DNA
<213>  homo sapiens

<400>  1401
atgccgcagc tgaacggcgg tggaggggat gacctaggcg ccaacgacga actgatttcc       60

ttcaaagacg agggcgaaca ggaggagaag agctccgaaa actcctcggc agagagggat      120

ttagctgatg tcaaatcgtc tctagtcaat gaatcagaaa cgaatcaaaa cagctcctcc      180

gattccgagg cggaaagacg gcctccgcct cgctccgaaa gtttccgaga caaatcccgg      240

gaaagtttgg aagaagcggc caagaggcaa gatggagggc tctttaaggg gccaccgtat      300

cccggctacc ccttcatcat gatccccgac ctgacgagcc cctacctccc caacggatcg      360

ctctcgccca ccgcccgaac ctatctccag atgaaatggc cactgcttga tgtccaggca      420

gggagcctcc agagtagaca agccctcaag gatgcccggt ccccatcacc ggcacacatt      480

gtctctaaca aagtgccagt ggtgcagcac cctcaccatg tccaccccct cacgcctctt      540

atcacgtaca gcaatgaaca cttcacgccg ggaaacccac ctccacactt accagccgac      600

gtagacccca aaacaggaat cccacggcct ccgcaccctc cagatatatc cccgtattac      660

ccactatcgc ctggcaccgt aggacaaatc ccccatccgc taggatggtt agtaccacag      720

caaggtcaac cagtgtaccc aatcacgaca ggaggattca gacaccccta ccccacagct      780

ctgaccgtca atgcttccat gtccaggttc cctccccata tggtcccacc acatcatacg      840

ctacacacga cgggcattcc gcatccggcc atagtcacac caacagtcaa acaggaatcg      900

tcccagagtg atgtcggctc actccatagt tcaaagcatc aggactccaa aaaggaagaa      960

gaaaagaaga agccccacat aaagaaacct cttaatgcat tcatgttgta tatgaaggaa     1020

atgagagcaa aggtcgtagc tgagtgcacg ttgaaagaaa gcgcggccat caaccagatc     1080

cttgggcgga ggtggcatgc actgtccaga gaagagcaag cgaaatacta cgagctggcc     1140

cggaaggagc gacagcttca tatgcaactg taccccggct ggtccgcgcg ggataactat     1200

ggaaagaaga agaagaggaa aagggacaag cagccgggag agaccaatga acacagcgaa     1260

tgtttcctaa atccttgcct ttcacttcct ccgattacag acctgagcgc tcctaagaaa     1320

tgccgagcgc gctttggcct tgatcaacag aataactggt gcggcccttg caggagaaaa     1380

aaaaagtgcg ttcgctacat acaaggtgaa ggcagctgcc tcagcccacc ctcttcagat     1440

ggaagcttac tagattcgcc tcccccctcc ccgaacctgc taggctcccc tccccgagac     1500

gccaagtcac agactgagca gacccagcct ctgtcgctgt ccctgaagcc cgaccccctg     1560

gcccacctgt ccatgatgcc tccgccaccc gccctcctgc tcgctgaggc cacccacaag     1620

gcctccgccc tctgtcccaa cggggccctg gacctgcccc cagccgcttt gcagcctgcc     1680

gccccctcct catcaattgc acagccgtcg acttcttcct tacattccca cagctccctg     1740

gccgggaccc agccccagcc gctgtcgctc gtcaccaagt ctttagaata g              1791


<210>  1402
<211>  2514
<212>  DNA
<213>  homo sapiens

<400>  1402
atgtcattgt cccacttata ccgggatggg gaaggccgca ttgatgatga tgatgacgag       60

cgggagaact ttgagatcac tgactgggat ctccagaatg agttcaaccc caaccgacag      120

cgccactggc agaccaagga agaagccacc tacggggtgt gggcagagcg agactcggat      180

gatgagaggc ccagctttgg aggcaaacgg gcccgtgact actctgcgcc agtcaacttc      240

atcagcgcag ggctcaagaa aggggcagcg gaggaggcag agttggaaga ttctgatgac      300

gaagagaaac ctgttaagca ggacgacttt cctaaggatt ttggaccaag gaagctaaaa      360

acgggtggca attttaagcc cagccagaaa ggttttgcag gaggaaccaa atctttcatg      420

gacttcggca gctgggaaag acacacaaaa ggaattggac agaagcttct tcagaagatg      480

ggctacgtcc ctggacgggg cctcgggaag aatgcacaag gtatcattaa cccaattgaa      540

gccaagcaga gaaagggaaa aggtgctgtg ggggcttatg gatccgagcg caccactcag      600

tccatgcaag acttccctgt ggttgactca gaggaagaag ctgaagagga gtttcagaag      660

gagctgagcc agtggaggaa agacccaagt ggaagcaaga agaagcccaa atactcttac      720

aagaccgtgg aagagttgaa ggccaagggc aggattagca agaagctcac tgctccccag      780

aaggaacttt ctcaagtcaa ggtcatagac atgacaggcc gggagcagaa ggtctactac      840

agctacagtc agatcagcca caagcacaac gttcccgatg atgggctgcc gctacagtcc      900

caacagctgc cacagtctgg caaagaggcc aaggcccccg gcttcgcgct gcccgagctg      960

gagcacaacc tgcagctgct catcgacctc acggagcagg agatcatcca gaatgaccgg     1020

cagctacagt atgagcggga catggtggtc aacctcttcc acgagctgga gaagatgacc     1080

gaggtcctgg accacgagga gcgggtcatc tcgaacctca gcaaggtcct ggagatggtg     1140

gaggagtgcg agcggcggat gcagcccgac tgcagcaacc ccctcaccct ggacgagtgt     1200

gcccgcatct tcgaaaccct gcaggacaag tactatgagg agtacaggat gtccgaccgt     1260

gtggaccttg ctgtggccat cgtctatcca ctcatgaagg agtacttcaa ggagtgggat     1320

cccctcaaag actgcactta tggcaccgag atcatctcta agtggaaaag cctcctagag     1380

aatgaccagc tcttgtccca tggcggacag gacctctcag cagatgcctt tcacaggttg     1440

atatgggaag tctggatgcc ttttgttcga aatattgtca cccagtggca gccaaggaac     1500

tgtgacccga tggtggactt tttggatagt tgggtgcaca ttattcctgt gtggatctta     1560

gataacatac tggaccaact catcttcccc aagctgcaaa aggaggtgga aaactggaac     1620

ccgctcacag acactgttcc catccactct tggatccacc catggctgcc ccttatgcag     1680

gcacggctgg agccactcta ttcccccatc cgtagtaagc tgtccagcgc cctgcagaag     1740

tggcacccca gcgactcctc tgccaagctc atcctccagc cctggaagga tgtcttcact     1800

cctggctcct gggaagcatt catggtcaaa aacatagtgc ccaagctggg gatgtgtctt     1860

ggtgagctag tcattaaccc ccaccagcag cacatggatg cattctattg ggtgattgac     1920

tgggaaggga tgatctctgt ctctagcctg gtgggacttc ttgaaaagca cttcttcccc     1980

aagtggcttc aggtgctgtg ctcttggctc agtaacagcc caaattatga ggagatcacc     2040

aagtggtacc tgggttggaa gtcgatgttc tcagaccaag tgctggcaca tccatctgtc     2100

aaggacaaat ttaatgaggc acttgatatc atgaaccggg cggtgtcctc caacgttggt     2160

gcctacatgc agccaggagc acgggagaac attgcctatc tcacccacac ggagcggagg     2220

aaggacttcc agtacgaggc catgcaggag aggcgggagg ctgagaacat ggctcagagg     2280

ggcattggcg tggccgctag ctctgtgccc atgaacttta aggacctcat tgagaccaag     2340

gctgaggagc acaacattgt cttcatgccc gtcattggga agcgacacga agggaagcag     2400

ctctacacct ttggccgcat tgtgatctac atcgaccggg gagtggtctt tgtccagggc     2460

gagaagacgt gggtgcccac ctcactgcag agcctgatcg acatggccaa gtga           2514


<210>  1403
<211>  2562
<212>  DNA
<213>  homo sapiens

<400>  1403
atgtgctgcg agaagtggag ccgcgtggcg gaaatgtttc tcttcattga ggagcgggag       60

gattgtaaga tactgtgcct ttgctccagg gcatttgtgg aggatcgaaa attgtacaat      120

ttgggattaa aaggctatta catcagagac agtggcaaca attcaggaga ccaggcgaca      180

gaagaagagg aaggtggtta ttcctgtggt actgcagaat cacatgacag caaaggcata      240

ggcctggatg aaagtgaact tgattctgag gctgaactca tgagaagtat gggattgcca      300

cttcaatttg gtaggataac tgcacataag gattttgagg tatctatgaa tactagaaat      360

aaagttaaaa taaaaaagaa aaaacatcaa aagaaatact tagatgaaat tgtgcaagaa      420

tcttggagaa aagaatatga agaagacgac attttggctt cagatgatcc atcttcaatt      480

gaacagtatg agaacaccag aacatatgaa cttcaaagca aaaaagatac tgagacagaa      540

aatcctccag ttgaaaacac attatctcca aagctagaaa ttacagagaa atgggaaaag      600

tattggaatg aatatggagg aggactattg tggcaaagtt ggcaagaaaa acatccgggt      660

caagcactat cttctgaacc ttggaacttt cctgatacaa aggaagaatg ggagcaacat      720

tatagtcaac tttattggta ttatttggaa caatttcagt attgggaagc tcagggttgg      780

acttttgatg cctcgcaaag ctgtgataca gatacttaca catctaaaac agaagctgat      840

gacaagaacg atgaaaaatg catgaaagtt gacttagtat cttttccatc ttcacctatt      900

atggttgata atgatagctc tggtacaagt gataaggatc atagtgaaat acttgatgga      960

attagtaaca taaaactgaa ttcagaggaa gtaacacaga gccaattaga ttcctgtaca     1020

agtcatgatg gtcatcaaca gctaagtgaa gttagtagca aaagagagtg ccctgcttcc     1080

ggccaaagtg aaccacgtaa tggaggaacc aatgaggaaa gcaactcatc ggggaataca     1140

aacacagacc caccagctga ggattcacag aagtcttcag gagcaaacac aagcaaagac     1200

agaccacatg ccagtggtac tgatggagat gaaagtgagg aagacccacc tgagcataag     1260

ccaagcaaac tgaagaggag ccatgaactg gacattgatg aaaacccagc ttcagacttt     1320

gatgacagtg gttcccttct aggattcaag tatggctcag gacaaaaata tggtggaatc     1380

ccaaatttca gtcatcggca ggtcaggtat ttagagaaga atgtgaagct taagtctaag     1440

tacctagaca tgcgcagaca aataaagatg aaaaacaaac acatcttctt taccaaagag     1500

tcagaaaaac catttttcaa gaaaagcaaa attctgagta aggtagaaaa attcctcaca     1560

tgggttaata aaccaatgga tgaagaagca tcacaggaat catcttctca tgacaatgtg     1620

cacgacgctt ccacaagtag tgattcagag gaacaagaca tgtctgttaa aaaaggtgat     1680

gacctactgg agactaataa tccagaacct gaaaagtgtc agagcgtatc ttcagctggt     1740

gaacttgaaa cagaaaacta tgaaagagac agcttgctag caactgttcc agatgagcag     1800

gattgtgtta ctcaagaagt gccagactcc cgccaggcag aaactgaagc tgaagtgaaa     1860

aagaagaaga acaagaagaa gaacaaaaag gtgaatggtc tgcctcctga aatagctgct     1920

gttcctgagc tggcaaaata ctgggcccag aggtacaggc tcttctcccg ttttgatgat     1980

gggattaagt tggacagaga gggctggttt tcagttacac ccgagaagat tgctgaacac     2040

attgctggcc gtgttagtca gtccttcaag tgtgacgttg tagtagacgc attctgtgga     2100

gttggaggaa ataccattca gtttgcctta acaggaatga gagtgattgc cattgatatc     2160

gatcctgtta agattgccct tgctcgcaat aatgcagaag tttatgggat agcagataag     2220

atagagttca tctgtggaga tttcttgctg ctggcttctt ttttaaaggc tgatgttgtg     2280

ttcctcagcc caccttgggg agggccagac tatgccactg cagagacctt tgacattaga     2340

acaatgatgt ctcctgatgg ctttgaaatt ttcagacttt ctaagaagat cactaataat     2400

attgtttatt ttcttccaag aaatgctgat attgaccagg tggcatcctt agctgggcct     2460

ggagggcaag tggaaataga acagaacttc cttaacaaca aattgaagac aatcactgca     2520

tattttggtg acctaattcg aagaccagcc tctgaaacct aa                        2562


<210>  1404
<211>  4782
<212>  DNA
<213>  homo sapiens

<400>  1404
atggcggccg cggctgtggt ggttcccgca gagtggataa agaactggga gaaatcaggg       60

agaggcgaat ttttgcattt atgtcggatc ctcagtgaaa ataaaagcca tgatagttca      120

acatacagag atttccagca agctctctat gagttgtcat atcatgtaat taaaggaaat      180

ctaaagcatg aacaggcatc taatgttctt agtgacatta gtgaatttcg tgaggatatg      240

ccctccattc ttgctgatgt attctgcata ttagacattg agacaaattg tttagaagaa      300

aaaagcaaga gagactattt tacacagttg gtattagcat gtttgtattt agtttcagac      360

acagttctaa aggaacgcct ggatccagaa acactggaat cattagggct tatcaaacaa      420

tcacagcaat tcaatcaaaa gtcagttaaa atcaagacaa aactctttta taagcagcaa      480

aaattcaatt tgttaagaga agagaatgaa ggttatgcca agctgattgc tgaattgggg      540

caagatttat ctggaagtat tactagtgat ttaatcttag aaaatatcaa atctttaata      600

ggatgcttta atctggatcc caatagagtt ttggatgtca ttttagaagt gtttgaatgc      660

aggccagaac acgatgactt ctttatatct ttgttagaat cttacatgag tatgtgtgaa      720

ccgcaaacac tgtgtcatat tcttgggttc aaattcaagt tttaccagga accaaatggc      780

gagacaccat catctttata cagagttgca gcagtacttc tacaatttaa tcttattgat      840

ttagatgatc tttatgtaca tcttcttccg gctgataatt gcattatgga tgaacacaaa      900

cgagaaattg cggaagctaa gcaaattgtt agaaagctta cgatggttgt gttgtcttct      960

gaaaaaatgg atgagcgaga gaaagaaaag gaaaaagaag aggagaaagt agagaaacca     1020

cctgataacc aaaaacttgg cttgttggaa gccttattaa agattggtga ttggcaacat     1080

gcacagaaca ttatggatca gatgcctcca tactatgcag cttcacacaa gctaatagcc     1140

cttgctattt gcaagctcat tcatataact attgagcctc tctaccgaag agttggagtt     1200

cctaaaggtg ctaaaggctc acctgttaat gctttgcaaa acaagagagc accaaaacaa     1260

gctgagagct ttgaagattt gaggagagac gtgttcaata tgttctgtta ccttggtcct     1320

cacctttctc acgatcccat tttatttgca aaagtggtgc gcataggcaa gtcatttatg     1380

aaggagtttc agtctgatgg aagcaaacaa gaagataaag aaaaaacgga agttatcctt     1440

agctgtttgc ttagcattac tgaccaggta ctacttccat ctctttcttt gatggactgc     1500

aatgcttgta tgtctgagga actatgggga atgtttaaaa catttccata tcagcataga     1560

tatcgtctgt atggccagtg gaagaatgaa acttataaca gtcacccact tttagtaaaa     1620

gttaaagctc aaacaataga cagagccaaa tatatcatga agcgcctaac caaggaaaat     1680

gtgaagcctt ctggaagaca aattgggaag ttgagccaca gcaatccaac cattttgttt     1740

gattatatct tgtcacaaat acagaagtat gataacttaa taacacctgt agtagattca     1800

ttgaaatacc tcacttcact gaattatgat gtcttggcct attgtatcat tgaagcttta     1860

gctaatccag aaaaggaaag aatgaaacat gatgacacaa ccatctcaag ctggcttcag     1920

agtctggcta gtttctgtgg tgcagttttt cgtaaatatc caattgatct tgctggtctt     1980

cttcagtatg ttgccaatca gctaaaggcg ggcaaaagtt ttgacctgct tatattgaaa     2040

gaagtggtac aaaaaatggc aggaatagaa attacagagg aaatgacaat ggagcaacta     2100

gaggctatga ctggtggaga gcagctaaaa gctgagggtg gttattttgg tcagatcaga     2160

aacactaaaa aatcctctca gagattaaag gatgctctat tggaccatga tcttgccctt     2220

cctctctgtc tgcttatggc tcagcagaga aatggggtaa tctttcagga aggtggagag     2280

aaacatttga aacttgtggg aaagctctat gaccagtgtc atgataccct ggtgcagttt     2340

ggtgggtttt tagcatctaa tctgagcaca gaagattata taaagcgagt gccttcaatt     2400

gatgtactct gtaatgaatt tcatacaccc catgatgcag catttttcct gtctaggcca     2460

atgtatgccc atcatatttc gtcaaagtat gatgaactta aaaaatcaga aaagggaagt     2520

aaacagcaac ataaagttca taagtacatt acatcatgtg agatggtgat ggcgcctgtc     2580

catgaagcag tggtctcctt acatgtttcc aaagtctggg atgacatcag ccctcaattc     2640

tatgctacat tctggtcatt gacaatgtat gaccttgcag ttccacacac cagctatgaa     2700

cgagaagtca ataaacttaa agtccagatg aaagcaattg atgacaatca ggaaatgccc     2760

ccaaataaaa agaaaaaaga gaaggagcgc tgtactgccc ttcaggacaa gcttcttgaa     2820

gaagaaaaga aacagatgga acatgtacag agagttctac agagattgaa actggaaaag     2880

gacaactggc ttttagcaaa atctaccaaa aatgagacca tcacaaaatt tctacagctg     2940

tgtatatttc ctcgatgtat tttttcagca attgatgctg tttactgtgc tcgttttgtt     3000

gaattggtac atcaacagaa aactccaaat ttttccacac ttctttgcta tgatcgagtt     3060

ttctctgaca taatttacac agttgcaagc tgtactgaaa atgaagccag tcgatacgga     3120

aggtttcttt gctgcatgtt agagactgtg accaggtggc atagtgatag agccacatat     3180

gaaaaggaat gtggaaacta tccaggattc cttaccatat tacgggcaac tggatttgat     3240

ggtggaaata aggctgatca attagactat gaaaattttc gacatgttgt acataaatgg     3300

cattacaaac taaccaaggc atcggtacat tgccttgaaa caggcgaata tactcacatc     3360

aggaatatct tgattgtgct aacaaaaata cttccttggt acccaaaagt tttgaatctg     3420

ggtcaagctt tggaaagaag agtacacaaa atctgccaag aagaaaaaga gaagaggcca     3480

gatctatatg cattggctat gggctactct gggcagttga aaagtagaaa gtcatacatg     3540

atacctgaaa atgagtttca tcacaaagac ccccctccga ggaatgcagt tgccagtgtg     3600

caaaatgggc ctggtggtgg gccttcttca tcatcaatag gaagtgcatc taaatcggat     3660

gaaagcagta ctgaggagac tgataaatca agggagagat ctcagtgtgg tgtgaaagct     3720

gttaataaag cttctagtac cacacctaaa gggaattcaa gcaatggaaa tagtggctct     3780

aacagcaaca aagctgttaa agaaaatgac aaagaaaaag ggaaagagaa agaaaaagag     3840

aaaaaagaaa agactccagc tactactcca gaggccaggg tacttggtaa agatggtaaa     3900

gaaaaaccaa aggaagagcg gccaaataaa gatgaaaaag caagagagac caaggaaaga     3960

acgccgaagt ctgacaaaga gaaagaaaaa ttcaagaagg aagaaaaagc taaagatgag     4020

aaatttaaga ccactgtccc caacgcagaa tcaaaatcaa ctcaagaaag ggaaagagag     4080

aaggagccat ccagagaaag agatatagca aaggaaatga aatcaaagga aaatgttaaa     4140

ggaggagaaa aaacaccagt ttctgggtcc ttgaaatcac ctgttcccag atcagatatt     4200

ccagagcctg aaagggaaca aaaacgccgc aaaattgata ctcacccttc tccatcacat     4260

tcctccacag taaaggacag tctcatcgaa ctcaaggaat cttcagcaaa gctctacatt     4320

aatcatactc ctccaccact gtccaagagt aaggagagag aaatggacaa gaaagatttg     4380

gacaagtcaa gggaaagatc cagagaaaga gagaaaaaag atgaaaagga caggaaagag     4440

cggaaaaggg atcactcaaa caacgaccgt gaagtgccac cggacttaac caagagacgt     4500

aaagaggaga atggaacaat gggggtttca aaacataaaa gtgaaagtcc ttgtgaatct     4560

ccttatccaa atgagaaaga caaggaaaaa aataagtcaa aatcttcagg caaagaaaaa     4620

ggcagtgatt catttaaatc tgagaagatg gataaaatct cctccggtgg caaaaaggag     4680

tccaggcatg ataaagaaaa gatagaaaag aaagagaaac gggacagttc aggaggaaag     4740

gaagagaaga aacatcataa gtcctcggac aagcacagat aa                        4782


<210>  1405
<211>  1128
<212>  DNA
<213>  homo sapiens

<400>  1405
atggaggacg agatgcccaa gactctatac gtcggtaacc tttccagaga tgtgacagaa       60

gctctaattc tgcaactctt tagccagatt ggaccttgta aaaactgcaa aatgattatg      120

gatacagctg gaaatgatcc ctattgtttt gtggagtttc atgagcatcg tcatgcagct      180

gcagcattag ctgctatgaa tggacggaag ataatgggta aggaagtcaa agtgaattgg      240

gcaacaaccc ctagcagtca aaagaaagat acaagcaatc atttccatgt ctttgttggt      300

gatctcagcc cagaaattac aactgaagat ataaaagctg cttttgcacc atttggaaga      360

atatcagatg cccgagtggt aaaagacatg gcaacaggaa agtctaaggg atatggcttt      420

gtctcctttt tcaacaaatg ggatgctgaa aacgccattc aacagatggg tggccagtgg      480

cttggtggaa gacaaatcag aactaactgg gcaacccgaa agcctcccgc tccaaagagt      540

acatatgagt caaataccaa acagctatca tatgatgagg ttgtaaatca gtctagtcca      600

agcaactgta ctgtatactg tggaggtgtt acttctgggc taacagaaca actaatgcgt      660

cagacttttt caccatttgg acaaataatg gaaattcgag tctttccaga taaaggatat      720

tcatttgttc ggttcaattc ccatgaaagt gcagcacatg caattgtttc tgttaatggt      780

actaccattg aaggtcatgt tgtgaaatgc tattggggca aagaaactct tgatatgata      840

aatcccgtgc aacagcagaa tcaaattgga tatccccaac cttatggcca gtggggccag      900

tggtatggaa atgcacaaca aattggccag tatatgccta atggttggca agttcctgca      960

tatggaatgt atggccaggc atggaaccag caaggattta atcagacaca gtcttctgca     1020

ccatggatgg gaccaaatta tggagtgcaa ccgcctcaag ggcaaaatgg cagcatgttg     1080

cccaatcagc cttctgggta tcgagtggca gggtatgaaa cccagtga                  1128


<210>  1406
<211>  2301
<212>  DNA
<213>  homo sapiens

<400>  1406
atgagtgtcc aaagtagcag tggaagtttg gaggggccgc catcttggtc ccagctctcc       60

acgtctccaa ccccgggctc ggcggcggcg gccaggtccc tgctgaatca cacgccgcca      120

tccgggaggc ccagggaagg tgcaatggat gagcttcata gtctggatcc aagaaggcaa      180

gagttattgg aagctagatt tactggagtt gcaagtggga gcactggaag tacgggcagt      240

tgcagtgttg gagctaaagc ctcaacaaat aacgaaagct ctaatcacag ttttggaagc      300

ttgggatctt taagtgacaa agaatcagag acaccggaga agaaacaatc ggaatcatcc      360

aggggaagaa agagaaaagc agaaaaccag aatgaaagta gtcagggaaa aagtattggg      420

ggacgtggcc acaaaattag cgactatttt gaataccagg gtggaaatgg ctcaagtcca      480

gtaagaggca tacctcctgc aatccgttct cctcaaaatt cacattcaca ttccactcct      540

tcctcatctg ttcgaccgaa tagcccttct cctactgcat tagcatttgg ggaccaccct      600

attgtacaac caaagcaatt atcctttaaa attattcaga ctgatctcac aatgctgaaa      660

ttagcagcat tagaaagtaa taaaatccag gacctggaaa agaaggaggg acgtatagat      720

gatttgctca gggctaactg tgatctcaga cggcaaatag atgaacaaca aaaattactt      780

gaaaaataca aagaacgatt aaataagtgc atatcaatga gcaagaaact tcttattgaa      840

aagagtacac aagaaaagct gtcaagcaga gagaagagta tgcaagatcg attacgcctc      900

gggcacttta caacagttag acatggcgct tcatttactg aacaatggac agatggtttt      960

gcatttcaga atcttgtgaa gcaacaagaa tgggtgaatc agcaaaggga agatattgaa     1020

aggcaaagga aacttctagc caaacgcaaa cctcccacag ctaataattc tcaggcaccc     1080

tctaccaatt ctgaaccaaa acaaaggaaa aacaaagcag tcaatggagc agagaatgat     1140

ccctttgtta gaccaaattt accacaactg ttgactttgg cagaatatca tgaacaggaa     1200

gaaattttca aacttagact aggacatctc aaaaaggaag aggcagaaat ccaggcagaa     1260

cttgaacgtt tggaaagagt cagaaatctt cacatacgtg agctgaaaag aataaacaat     1320

gaagataatt cacagttcaa agatcaccca acattaaatg aaagatattt attacttcat     1380

ctgcttggta gaggtggctt tagtgaagtg tataaggctt ttgaccttta tgaacaaaga     1440

tatgctgctg tgaagataca tcagcttaat aaaagctgga gagatgagaa gaaagaaaac     1500

taccacaaac atgcctgcag agagtataga atacacaaag aactggatca ccccagaata     1560

gttaaactct atgattattt ctccttggat acagatacgt tttgtacagt gttagaatac     1620

tgtgaaggca atgacttgga tttctatctg aagcaacaca agttaatgtc agagaaagaa     1680

gctcggtcta ttgtaatgca gattgtaaat gcactaagat atctcaatga gatcaaaccc     1740

cctattatac attatgatct taagccagga aacatcctac tggtagatgg aacagcatgt     1800

ggtgaaatca aaatcactga ttttggtctg tccaagatta tggatgatga tagctatggt     1860

gtagatggaa tggatctaac ttcccagggg gcaggcactt actggtattt acctcctgag     1920

tgttttgtag ttggaaaaga gccaccaaag atttccaaca aggttgatgt atggtcggtt     1980

ggagtcatct tctttcagtg tctttatggt agaaagccat ttggtcacaa tcaatctcaa     2040

caagacattc ttcaagaaaa tacaatatta aaagccacag aagtccagtt ccctgtaaaa     2100

ccggttgtaa gcagtgaagc caaggcattt ataagacgct gtttggcata tcgaaaagaa     2160

gatcgatttg atgtgcacca gctggcaaat gacccatacc ttctcccaca catgagaaga     2220

tcaaattctt caggaaacct acacatggct gggctgacag catcccctac acccccttct     2280

tcaagcataa ttacttactg a                                               2301


<210>  1407
<211>  1668
<212>  DNA
<213>  homo sapiens

<400>  1407
atggcggcgg ctgcgtggct tcaggtgttg cctgtcattc ttctgcttct gggagctcac       60

ccgtcaccac tgtcgttttt cagtgcggga ccggcaaccg tagctgctgc cgaccggtcc      120

aaatggcaca ttccgatacc gtcggggaaa aattatttta gttttggaaa gatcctcttc      180

agaaatacca ctatcttcct gaagtttgat ggagaacctt gtgacctgtc tttgaatata      240

acctggtatc tgaaaagcgc tgattgttac aatgaaatct ataacttcaa ggcagaagaa      300

gtagagttgt atttggaaaa acttaaggaa aaaagaggct tgtctgggaa atatcaaaca      360

tcatcaaaat tgttccagaa ctgcagtgaa ctctttaaaa cacagacctt ttctggagat      420

tttatgcatc gactgcctct tttaggagaa aaacaggagg ctaaggagaa tggaacaaac      480

cttaccttta ttggagacaa aaccgcaatg catgaaccat tgcaaacttg gcaagatgca      540

ccatacattt ttattgtaca tattggcatt tcatcctcaa aggaatcatc aaaagaaaat      600

tcactgagta atctttttac catgactgtt gaagtgaagg gtccctatga atacctcaca      660

cttgaagact atcccttgat gatttttttc atggtgatgt gtattgtata tgtcctgttt      720

ggtgttctgt ggctggcatg gtctgcctgc tactggagag atctcctgag aattcagttt      780

tggattggtg ctgtcatctt cctgggaatg cttgagaaag ctgtcttcta tgcggaattt      840

cagaatatcc gatacaaagg agaatctgtc cagggtgctt tgatccttgc agagctgctt      900

tcagcagtga aacgctcact ggctcgaacc ctggtcatca tagtcagtct gggatatggc      960

atcgtcaagc cacgccttgg agtcactctt cataaggttg tagtagcagg agccctctat     1020

cttttgttct ctggcatgga aggggtcctc agagttactg gggcccagac tgatcttgct     1080

tccttggcct ttatcccctt ggctttccta gacactgcct tgtgctggtg gatatttatt     1140

agcctgactc aaacaatgaa gctattaaaa cttcggagga acattgtaaa actctctttg     1200

tatcggcatt tcaccaacac gcttattttg gcagtggcag catccattgt gtttatcatc     1260

tggacaacca tgaagttcag aatagtgaca tgtcagtcgg actggcggga gctgtgggta     1320

gacgatgcca tctggcgctt gctgttctcc atgatcctct ttgtcatcat ggttctctgg     1380

cgaccatctg caaacaacca gaggtttgcc ttttcaccat tgtctgagga agaggaggag     1440

gatgaacaaa aggagcctat gctgaaagaa agctttgaag gaatgaaaat gagaagtacc     1500

aaacaagaac ccaatggaaa tagtaaagtt aacaaagcac aggaagatga tttgaagtgg     1560

gtagaagaga atgttccttc ttctgtgaca gatgtagcac ttccagccct tctggattca     1620

gatgaggaac gaatgatcac acactttgaa aggtccaaaa tggagtaa                  1668


<210>  1408
<211>  705
<212>  DNA
<213>  homo sapiens

<400>  1408
atggacccag ggctgcagca agcactcaac ggaatggccc ctcctggaga cacagccatg       60

catgtgccgg cgggctccgt ggccagccac ctggggacca cgagccgcag ctatttctat      120

ttgaccacag ccactctggc tctgtgcctt gtcttcacgg tggccactat tatggtgttg      180

gtcgttcaga ggacggactc cattcccaac tcacctgaca acgtccccct caaaggagga      240

aattgctcag aagacctctt atgtatcctg aaaagggctc cattcaagaa gtcatgggcc      300

tacctccaag tggcaaagca tctaaacaaa accaagttgt cttggaacaa agatggcatt      360

ctccatggag tcagatatca ggatgggaat ctggtgatcc aattccctgg tttgtacttc      420

atcatttgcc aactgcagtt tcttgtacaa tgcccaaata attctgtcga tctgaagttg      480

gagcttctca tcaacaagca tatcaaaaaa caggccctgg tgacagtgtg tgagtctgga      540

atgcaaacga aacacgtata ccagaatctc tctcaattct tgctggatta cctgcaggtc      600

aacaccacca tatcagtcaa tgtggataca ttccagtaca tagatacaag cacctttcct      660

cttgagaatg tgttgtccat cttcttatac agtaattcag actga                      705


<210>  1409
<211>  423
<212>  DNA
<213>  homo sapiens

<400>  1409
atgtctggga gcttctactt tgtaattgtt ggccaccatg ataatccagt ttttgaaatg       60

gagtttttgc cagctgggaa ggcagaatcc aaagacgacc atcgtcatct gaaccagttc      120

atagctcatg ctgctctcga cctcgtagat gagaacatgt ggctatcgaa caacatgtac      180

ttgaaaactg tggacaagtt caacgagtgg tttgtgtcgg catttgtcac tgcggggcat      240

atgaggttta ttatgcttca tgacataaga caagaagatg gaataaagaa cttctttact      300

gatgtttatg atttatatat aaagttttca atgaatccat tttatgaacc caattctcct      360

attcgatcaa gtgcatttga cagaaaagtt cagtttcttg ggaagaaaca ccttttaagc      420

tga                                                                    423


<210>  1410
<211>  5940
<212>  DNA
<213>  homo sapiens

<400>  1410
atgtcgtcct ggcttggggg cctcggctcc ggattgggcc agtctctggg tcaagtcggg       60

ggcagcctgg cttccctcac tggccagata tcaaacttta caaaggatat gctgatggag      120

ggcacggagg aagtggaagc agaattacct gattctagga caaaggaaat tgaagccatt      180

catgcaatct tgagatcaga gaatgaaagg cttaagaaac tttgtactga tctagaagag      240

aaacatgaag catcagagat tcaaataaag cagcaatcta caagttaccg aaatcaactt      300

caacaaaaag aggtagaaat cagccatctt aaagccagac agattgcact ccaggatcag      360

ttgctgaaac tgcagtcagc tgctcagtca gtaccttcag gagctggtgt accagcaacc      420

actgcatcat cttcattcgc ttatgggatt agtcatcatc cttcagcttt ccatgacgat      480

gacatggact ttggtgatat aatttcatcc caacaagaaa taaaccgact ctcaaatgaa      540

gtttcaagac ttgagtctga agttggccat tggaggcata ttgctcagac ttccaaagca      600

caaggaacag ataactctga tcaaagtgaa atatgtaaac tacaaaatat cattaaggaa      660

ctaaaacaga accgaagtca ggaaattgat gaccatcaac atgaaatgtc agtactgcag      720

aatgcacacc aacagaaatt gacagaaata agtcgacgac atcgagaaga attaagtgac      780

tatgaagaac gaattgaaga acttgaaaat ctgttacaac aaggtggctc tggagttata      840

gaaactgatc tctctaaaat ctatgagatg caaaaaacta ttcaagttct acaaatagaa      900

aaagtggagt ctaccaaaaa aatggaacaa cttgaggata aaataaaaga tataaataaa      960

aaattatctt ctgcagaaaa tgacagagat attttgagga gagaacaaga acagctaaat     1020

gtggaaaaga gacaaataat ggaagaatgt gaaaacttga aattggaatg tagtaaattg     1080

cagccttctg ctgtgaagca aagtgatact atgacagaaa aggaaagaat tcttgcccag     1140

agtgcatcag tggaagaagt gttcagacta caacaagcac tgtctgatgc cgaaaatgaa     1200

ataatgagat tgagtagttt aaaccaggat aacagtcttg ctgaagacaa tctgaaactt     1260

aaaatgcgta tcgaagtttt agaaaaagag aagtcattac tgagtcaaga aaaggaagaa     1320

cttcagatgt cacttttaaa attgaacaat gaatatgaag taattaaaag tacagctaca     1380

agagacataa gtttggattc agaattacat gacttaagac ttaatttgga ggcaaaggaa     1440

caagaactca atcagagtat tagtgaaaag gaaacactga tagctgagat agaagaattg     1500

gacagacaga atcaagaagc tacaaagcac atgattttga taaaagatca gctatcaaaa     1560

caacaaaatg aaggagatag catcatcagt aaactgaaac aagatctaaa tgatgaaaaa     1620

aagagagttc atcaacttga agatgataaa atggacatta ctaaagagtt agatgtacag     1680

aaagaaaagc taattcaaag tgaagtggcc ctaaatgatt tacatttaac caagcagaaa     1740

cttgaggaca aagtagaaaa tttagtagat cagctaaata aatcacaaga aagtaatgta     1800

agcatccaga aggagaattt agaacttaag gagcatatta gacaaaatga ggaggagctt     1860

tctagaataa ggaatgagtt aatgcagtct ctaaatcaag actctaatag taattttaag     1920

gataccttac ttaaagaaag agaagctgaa gttagaaact taaagcaaaa tctttcagaa     1980

ttagaacagc tcaatgaaaa tttaaagaaa gttgcttttg atgtcaaaat ggaaaatgaa     2040

aagttagttt tagcatgtga agatgtgagg catcagttag aagaatgtct tgctggtaac     2100

aatcagcttt ctctggaaaa aaacactatt gtggagactc taaaaatgga aaaaggagag     2160

atagaggcag aattgtgttg ggctaaaaag aggctgttgg aagaagcaaa caagtatgag     2220

aaaaccattg aagaactgtc aaatgcacgt aatttgaata cctctgcctt acagctggaa     2280

catgagcatt taattaaact caatcaaaag aaagacatgg aaatagcaga actcaaaaag     2340

aatattgaac aaatggatac tgaccataaa gaaactaagg acgttttgtc atctagttta     2400

gaagagcaga agcagttgac acaacttata aacaagaaag aaatttttat tgaaaagctt     2460

aaagaaagaa gttcaaagct gcaggaggaa ttggataaat attctcaggc cttaagaaaa     2520

aatgaaattt taagacagac catagaggaa aaagaccgaa gtcttggatc catgaaagag     2580

gaaaataatc atctgcaaga agaattggaa cgactcaggg aagagcagag tcgaaccgca     2640

cctgtggctg accctaaaac ccttgatagt gttactgaac tagcatctga ggtatctcaa     2700

ctgaacacga tcaaggaaca tcttgaagag gaaattaaac atcatcaaaa gataattgaa     2760

gatcaaaacc agagtaagat gcaactactt cagtctttac aagagcaaaa gaaggaaatg     2820

gatgagttta gataccagca tgagcaaatg aacgccacac acacccagct ctttttagag     2880

aaggatgagg aaattaagag tttgcaaaaa acaattgaac aaatcaaaac ccagttgcat     2940

gaagaaagac aggacattca aacagataac tctgatattt ttcaagaaac aaaagttcag     3000

agccttaata tagaaaatgg aagtgaaaag catgatttat ctaaagctga aacggaaaga     3060

ttagtgaaag gaataaaaga gcgagaactg gagattaaac ttctaaatga aaagaatata     3120

tctttaacta aacagattga tcagttgtcc aaagatgaag ttggtaaact aactcagatt     3180

attcagcaga aagatttgga gatacaagct cttcatgcta gaatttcttc aacttcccat     3240

actcaagatg ttgtttacct tcaacagcaa ctgcaggctt atgctatgga aagagaaaag     3300

gtatttgctg ttttgaatga gaagactagg gaaaatagcc atctaaaaac agaatatcac     3360

aaaatgatgg atattgttgc tgccaaggaa gcagctctta tcaaactgca agatgaaaat     3420

aaaaaattgt ccactagatt tgaaagtagt ggccaagata tgtttagaga aactattcag     3480

aatttatcac gtatcattcg agaaaaagac atcgaaatag atgcactaag tcagaaatgt     3540

cagactttat tggcagtttt acaaacatcc agcactggta atgaggctgg aggtgttaat     3600

agtaatcaat ttgaggagct tctacaggaa cgtgacaagt taaaacagca agtaaagaaa     3660

atggaagagt ggaagcagca ggtgatgacc acagtacaaa atatgcaaca cgagtcagcc     3720

cagcttcagg aagagcttca ccaacttcaa gcacaggttt tggttgacag tgataataat     3780

tctaaattac aagtggacta tactggcctg atccaaagtt atgagcagaa tgaaaccaaa     3840

ctcaaaaatt ttgggcagga attagcacaa gttcagcaca gcattgggca gctttgcaat     3900

accaaggatc ttcttttagg aaaacttgat attatttcac cccagctgtc ttctgcatca     3960

ttgcttactc cccagtctgc agagtgtctt agagcaagta agtctgaagt attgagtgaa     4020

tcttctgaat tgcttcagca agagttagaa gagctaagaa aatcactaca ggaaaaagat     4080

gcaacaatta gaactctcca ggaaaataac cacagattgt ctgattcgat tgctgccacc     4140

tcagagctag aaagaaaaga acacgaacaa accgattcag aaatcaagca gctaaaggag     4200

aaacaagatg ttttgcaaaa gttacttaag gaaaaagacc tcttaatcaa agccaaaagt     4260

gatcaactac tttcttccaa tgaaaatttc actaacaaag taaatgaaaa cgaacttttg     4320

aggcaggcag taacaaacct gaaggagaga atattaattc tagagatgga cattggcaaa     4380

ctaaaaggag aaaatgaaaa aatagtggaa acatacaggg gaaaggaaac agaatatcaa     4440

gcgttacaag agactaacat gaagttttct atgatgctgc gagaaaaaga gtttgagtgc     4500

cactcaatga aggagaaggc tcttgctttt gaacagctat tgaaagagaa agaacagggc     4560

aagactggag agttaaatca gcttttaaat gcagttaaat caatgcagga gaagacagtt     4620

gtgtttcaac aggagagaga ccaagtcatg ttggccctga aacaaaaaca aatggaaaat     4680

actgccctac agaatgaggt tcaacgttta cgtgacaaag aatttcgttc aaaccaagag     4740

ctagagagat tgcgtaatca tcttttagaa tcagaagatt cttatacccg tgaagctttg     4800

gctgcagaag atagagaggc taaactaaga aagaaagtca cagtattgga ggaaaagcta     4860

gtttcatcct ctaatgcaat ggaaaatgca agccatcaag ccagtgtgca ggtagagtca     4920

ttgcaagaac agttgaatgt agtttccaag caaagggatg aaactgcgct gcagctttct     4980

gtctctcagg aacaagtaaa gcagtatgct ctgtcactgg ccaacctgca gatggtacta     5040

gagcatttcc aacaagagga aaaagctatg tattctgctg aactcgaaaa gcaaaaacag     5100

cttatagctg aatggaagaa aaacgcagaa aatctggaag gaaaagtgat atcattacag     5160

gaatgtttgg atgaagcaaa tgctgcattg gattcagcat caagacttac agaacagtta     5220

gatgtaaaag aagaacaaat tgaagaactt aaaagacaaa atgagctccg acaagaaatg     5280

ctggatgatg tacaaaagaa attgatgagc ttagcaaaca gctcagaagg aaaagtagac     5340

aaagtcctaa tgagaaacct cttcattggt catttccaca caccgaaaaa tcagcgtcat     5400

gaagtgttac ggttaatggg gagcatcctg ggcgtcagaa gggaggagat ggagcagttg     5460

tttcatgacg atcagggcgg tgttaccagg tggatgactg ggtggcttgg aggaggatca     5520

aaaagtgttc ccaacacacc tttgagacca aatcagcaat ctgtggttaa tagttctttt     5580

tcagaacttt ttgttaaatt tctagaaaca gaatctcatc catccattcc accaccaaag     5640

ctttctgttc atgatatgaa acctctggat tcaccaggaa gaagaaaaag agatacaaat     5700

gcaccagaaa gttttaaaga tacagcagaa tccaggtctg gtagaagaac agatgtaaat     5760

ccgtttttgg ctcctcgctc ggcagctgta cctcttatta acccagctgg acttggacct     5820

ggtgggcccg ggcatcttct tctgaaaccc atctcagatg ttttgcccac atttacacct     5880

ttgccagcgt tacctgacaa cagtgctggg gttgtgctga aagacctttt aaagcaatag     5940


<210>  1411
<211>  3426
<212>  DNA
<213>  homo sapiens

<400>  1411
atggcggcgg cagtaggggt tcgtggccgg tacgagctgc cgccttgctc cggcccaggc       60

tggctcctca gcctttccgc cttgctgagt gtggcggcac gaggggcctt cgccaccacg      120

cactgggtcg tcacggagga cgggaaaatc cagcagcagg tggattcacc aatgaacttg      180

aagcatcctc atgacctagt catattaatg agacaagaag caacagttaa ctacctcaaa      240

gaattagaga aacaattagt tgctcaaaaa attcacatag aagagaatga ggacagagac      300

acaggactgg aacagagaca taataaagaa gacccagact gcatcaaagc caaggtgccc      360

ttaggggacc tggatctata tgatggcaca tacataactt tggagagcaa agacatcagt      420

cctgaagatt atatagacac agaatctcct gtccctccag acccagagca acctgattgt      480

actaaaattc tagaacttcc atatagtata catgcttttc agcacttgag aggtgtacag      540

gagagagtta atctttctgc acctctgcta cctaaagaag acccaatctt cacatattta      600

tctaaacggt taggaaggag tatagatgac ataggtcacc tcattcatga aggcctacag      660

aagaacactt cctcgtgggt actgtataac atggcttcat tttactggag aattaagaat      720

gagccatatc aggtagtaga atgtgccatg cgagcacttc acttctcttc caggcacaat      780

aaagacattg ccctggtcaa cctggcaaac gttctacaca gagcacactt ctctgctgat      840

gctgctgtcg tggtccatgc agctctggat gacagtgact tcttcaccag ctattacact      900

ttggggaata tatatgcaat gcttggggaa tataaccact cagtgctctg ttatgaccac      960

gctttgcagg ccagacctgg gtttgagcaa gctataaaga ggaagcatgc tgtcctatgt     1020

cagcaaaaac tggagcagaa attggaggct cagcatagat ctctccagcg aacactgaat     1080

gagttaaaag agtatcaaaa gcagcatgac cactacctga gacagcagga aatcctagaa     1140

aaacataaac tgattcagga ggagcaaatc ttaagaaata tcattcatga gactcagatg     1200

gcaaaagagg cacaattagg aaatcatcag atatgccgac tggtcaacca gcagcatagt     1260

ttacattgcc agtgggacca gcctgtacgc tatcatcgtg gagatatctt tgaaaatgtg     1320

gactatgttc agtttggtga ggattcatca acctccagta tgatgtctgt gaactttgat     1380

gttcaatcaa atcagagtga tatcaatgat tcggtcaagt cttctcccgt agcccattct     1440

attctctgga tttggggcag ggactctgat gcatataggg acaaacagca tattctatgg     1500

cctaaaagag cagattgtac agaaagctac cctagagtcc ctgttggtgg ggaattgcca     1560

acgtattttc tgcctccgga aaacaaagga ctcaggatcc acgaactcag cagtgatgat     1620

tattctacag aagaagaggc ccaaacccct gactgttcca taactgactt cagaaaaagc     1680

cacactctgt cctacttagt caaagaatta gaggttcgca tggatctgaa agccaaaatg     1740

ccagatgacc atgcacgaaa aattttgctt tcccgtatta ataactatac tatcccagaa     1800

gaagaaattg ggtctttctt atttcatgct attaataagc caaatgctcc tatctggctc     1860

atactcaatg aagctggact atactggaga gcagtaggaa atagcacttt tgctattgcc     1920

tgtcttcaga gggctttgaa tttagctcca cttcaatacc aagatgttcc tcttgtcaac     1980

ttggccaacc ttttgattca ttacggcctt catcttgatg ccactaagct gctacttcaa     2040

gctttggcca tcaatagctc tgagcctctg acctttttga gcctgggaaa tgcttacctt     2100

gctctgaaga atatcagtgg ggcacttgag gcctttagac aggccttgaa attaaccacc     2160

aaatgtccag agtgtgaaaa cagcctgaag ttgatccgct gtatgcagtt ttatcctttt     2220

ctgtacaaca tcacttcttc tgtttgcagt ggtacggtgg ttgaggagag caatggttct     2280

gatgagatgg agaattcaga tgaaaccaaa atgtcagaag aaatactggc tttggtggat     2340

gaatttcaac aggcatggcc tttggaaggc tttgggggtg cactagagat gaaagggcgg     2400

cgtctagact tacaaggaat acgggtgctg aagaaaggtc cccaggatgg agtggccaga     2460

agctcttgct atggagactg cagaagtgaa gatgatgaag caacagaatg gattacattc     2520

caggtcaaac gtgtaaagaa acccaaagga gatcataaga aaactcctgg gaaaaaagta     2580

gaaacaggtc agatagaaaa tggacatcgt taccaagcaa acctagagat cactggcccc     2640

aaggtggcat ctcctgggcc acaaggaaaa aaacgtgact accagcgtct gggatggccc     2700

agcccggacg aatgcctcaa actccgctgg gtagagctga ctgccatcgt gagtacctgg     2760

cttgcagttt cttcaaaaaa cattgacatc acagaacaca tagattttgc cacccctata     2820

cagcagccag caatggagcc tctttgcaat ggcaatctcc ccacgagtat gcataccctg     2880

gaccacttgc atggggtttc caaccgagcc agcctgcact acacagggga gagtcagtta     2940

acagaggtat tacaaaatct cggcaaagac caatatccac aacagtcgct tgaacagatt     3000

ggcacccgaa ttgccaaagt tttggaaaag aaccagacgt cctgggtcct ctccagcatg     3060

gcagccctct actggagggt gaaaggccaa ggaaagaagg caatcgactg cctccgccag     3120

gctctgcact atgcgccaca ccagatgaag gatgtgcccc tgattagcct ggccaacatc     3180

ttgcacaatg ccaagctctg gaatgacgcc gtcatagtag ccaccatggc agtagagatc     3240

gcaccacact ttgctgtgaa ccacttcact ctgggcaatg tctacgtggc aatggaagaa     3300

tttgaaaaag cactggtgtg gtatgaatcc acattgaagc ttcagcccga gtttgtccca     3360

gccaagaacc gaatccagac catccagtgt cacttaatgc tgaagaaggg acggcgctct     3420

ccttag                                                                3426


<210>  1412
<211>  2532
<212>  DNA
<213>  homo sapiens

<400>  1412
atgtggaccc cggagctggc aattctgagg ggattcccca ctgaggctga gcggcagcaa       60

tggaaacagg agggggtcgt cggttcagag agtggatctt tcctacaatt gctactggaa      120

gggaactatg aagccatatt cttaaattca atgactcaaa atatttttaa ttcaacaaca      180

accgctgaag aaaagattga tagctacctg gagaagcagg tagtaacatt cctggattac      240

tcaacagatt tggacacaac ggaaagacaa cagttgatat ttctacttgg tgtgagcagt      300

ttgcaacttt ttgttcagag caactggacg gggccccctg ttgacttaca ccctcaggac      360

tttttgtcat ctgttttgtt ccagcaattc agtgaggtta aaggactgga tgcatttgtt      420

ctgagcctgc tcactctaga tggtgaatca atctacagcc tgacctcgaa gcctatacta      480

ctgttattag cacgcattat cctagtgaat gtaagacata aactgacagc tattcagagc      540

ttgccatggt ggactttgag atgtgtgaat attcatcagc atttgcttga ggaacgctca      600

cctctgcttt ttactcttgc cgaaaactgt attgatcaag tgatgaaact acagaatctg      660

tttgtagatg attcaggtcg atatttggct attcaattcc atctggaatg tgcatatgtg      720

tttttatatt attatgagta cagaaaagca aaagatcagt tggatattgc taaggacatc      780

agccaattac aaattgattt gacaggtgct ttgggaaaaa gaacacggtt ccaggaaaat      840

tatgtggcac aactgattct agatgtaaga agggaagggg atgtcctttc aaattgtgaa      900

ttcactccag cacccactcc tcaggaacat ttaaccaaga atcttgagct caatgatgac      960

accattctga atgacataaa gttagcagat tgtgaacagt tccagatgcc ggatctgtgt     1020

gctgaagaga tcgctattat tcttggaatc tgcactaatt ttcaaaagaa taacccagtg     1080

cacacattaa ctgaagtgga gcttctggca tttacatcat gtttgctttc acaaccaaag     1140

ttctgggcca ttcagacatc agccttgatc ctccggacaa aacttgagaa aggaagtact     1200

cgccgagtgg aacgggcaat gaggcagaca caggctcttg cagaccaatt tgaagataaa     1260

actacatctg tattggaacg cctgaagatt ttctattgct gtcaagtacc acctcactgg     1320

gccattcagc gccaacttgc aagtttgctc tttgagttgg gatgtaccag ttcagccctt     1380

cagatatttg aaaagctaga aatgtgggaa gatgttgtca tttgttatga aagagccggg     1440

cagcacggaa aggcagaaga aatccttaga caagagctgg agaaaaaaga aacgcctagt     1500

ttatactgct tgcttggaga tgtcctcgga gaccattctt gctatgacaa ggcctgggag     1560

ttgtcccggt accgcagtgc tcgtgctcag cgctccaaag ccctccttca tcttcggaac     1620

aaggagtttc aagagtgtgt agagtgcttc gaacgctcgg ttaagattaa tcccatgcag     1680

ctcggggtgt ggttttctct cggttgtgcc tatttggcct tggaagacta tcaaggttca     1740

gcaaaggcat ttcagcgctg tgtgactcta gaacccgata atgctgaagc ttggaacaat     1800

ttgtcaactt cctatatccg attaaaacaa aaagtaaaag cttttagaac tttacaagaa     1860

gctctcaagt gtaactatga acactggcag atttgggaaa actacatcct caccagcact     1920

gacgttgggg aattttcaga agccattaaa gcttatcacc ggctcttgga cttacgtgac     1980

aaatacaaag atgttcaggt ccttaaaatt ctagtcaggg cagtgattga tgggatgact     2040

gatcgaagtg gagatgttgc aactggcctc aaaggaaagc tgcaggagtt atttggcaga     2100

gtgacttcaa gagtgacaaa tgatggagaa atctggaggc tgtatgccca cgtatatgga     2160

aatgggcaga gtgaaaagcc tgatgaaaat gaaaaggcat tccagtgcct ctcaaaggca     2220

tacaagtgtg acacccagtc caattgttgg gagaaagata ttacatcatt taaggaagtt     2280

gttcaaagag ccttaggact tgcacatgtg gccataaaat gcagtaaaaa caaatccagt     2340

tcccaagaag ctgtacaaat gctttcttct gttcgactca atttacgggg cttgttatct     2400

aaagcaaagc aactttttac agatgtggca actggagaaa tgtccaggga attagctgat     2460

gacataacag ctatggacac cttagtgaca gagctccaag acctaagcaa ccagtttcga     2520

aatcagtatt ga                                                         2532


<210>  1413
<211>  2340
<212>  DNA
<213>  homo sapiens

<400>  1413
atgacaccgg agtttgacga agaggtggtt tttgagaatt ctccacttta ccaatactta       60

caggatctgg gacacacaga ctttgaaata tgttcttctt tgtcaccaaa aacagaaaaa      120

tgcacaacag agggacaaca aaagcctcct acaagagtcc taccaaaaca aggtatcctg      180

ttaaaagtgg ctgaaaccat caaaagttgg attttttttt ctcagtgcaa taagaaagat      240

gacttacttc acaagttgga tattggattc cgactcgact cattacatac catcctgcaa      300

caggaagtcc tgttacaaga ggatgtggag ctgattgagc tacttgatcc cagtatcctg      360

tctgcagggc aatctcaaca acaggaaaat ggacaccttc caacactttg ctccctggca      420

acccctaata tttgggatct ctcaatgcta tttgccttca ttagcttgct cgttatgctt      480

cccacttggt ggattgtgtc ttcctggctg gtatggggag tgattctatt tgtgtatctg      540

gtcataagag ctttgagatt atggaggaca gccaaactac aagtgaccct aaaaaaatac      600

agcgttcatt tggaagatat ggccacaaac agccgagctt ttactaacct cgtgagaaaa      660

gctttacgtc tcattcaaga aaccgaagtg atttccagag gatttacact ggtcagtgct      720

gcttgcccat ttaataaagc tggacagcat ccaagtcagc atctcatcgg tcttcggaaa      780

gctgtctacc gaactctaag agccaacttc caagcagcaa ggctagctac cctatatatg      840

ctgaaaaact accccctgaa ctctgagagt gacaatgtaa ccaactacat ctgtgtggtg      900

ccttttaaag agctgggcct tggacttagt gaagagcaga tttcagaaga ggaagcacat      960

aactttacag atggcttcag cctgcctgca ttgaaggttt tgttccaact ctgggtggca     1020

cagagttcag agttcttcag acggttagcc ctattacttt ctacagccaa ttcacctcct     1080

gggcccttac ttactccagc acttctgcct catcgtatct tatctgatgt gactcaaggt     1140

ctacctcatg ctcattctgc ctgtttggaa gagcttaagc gcagctatga gttctatcgg     1200

tactttgaaa ctcagcacca gtcagtaccg cagtgtttat ccaaaactca acagaagtca     1260

agagaactga ataatgttca cacagcagtg cgtagcttgc agctccatct gaaagcatta     1320

ctgaatgagg taataattct tgaagatgaa cttgaaaagc ttgtttgtac taaagaaaca     1380

caagaactag tgtcagaggc ttatcccatc ctagaacaga aattaaagtt gattcagccc     1440

cacgttcaag caagcaacaa ttgctgggaa gaggccattt ctcaggtcga caaactgcta     1500

cgaagaaata cagataaaaa aggcaagcct gaaatagcat gtgaaaaccc acattgtaca     1560

gtagtacctt tgaagcagcc tactctacac attgcagaca aagatccaat cccagaggag     1620

caggaattag aagcttatgt agatgatata gatattgata gtgatttcag aaaggatgat     1680

ttttattact tgtctcaaga agacaaagag agacagaagc gtgagcatga agaatccaag     1740

agggtgctcc aagaattaaa atctgtgctg ggatttaaag cttcagaggc agaaaggcag     1800

aagtggaagc aacttctatt tagtgatcat gccgtgttga aatccttgtc tcctgtagac     1860

ccagtggaac ccataagtaa ttcagaacca tcaatgaatt cagatatggg aaaagtcagt     1920

aaaaatgata ctgaagagga aagtaataaa tccgccacaa cagacaatga aataagtagg     1980

actgagtatt tatgtgaaaa ctctctagaa ggtaaaaata aagataattc ttcaaatgaa     2040

gtcttccccc aaggagcaga agaaagaatg tgttaccaat gtgagagtga agatgaacca     2100

caagcagatg gaagtggtct gaccactgcc cctccaactc ccagggactc attacagccc     2160

tccattaagc agaggctggc acggctacag ctgtcaccag attttacctt cactgctggc     2220

cttgctgcag aagtggctgc tagatctctc tcctttacca ccatgcagga acagactttt     2280

ggtggtgagg aggaagaaca aataatagaa gaaaataaaa atgagataga agaaaagtaa     2340


<210>  1414
<211>  1503
<212>  DNA
<213>  homo sapiens

<400>  1414
atgattatat cacattttcc aaaatgtgtg gcagtttttg ccctccttgc tctgagtgtt       60

ggtgcactgg acacttttat tgctgcagta tatgagcatg cggtgatatt accaaacaga      120

acagaaacac ctgtttcaaa agaagaagct ttgctcctga tgaacaagaa catagatgtt      180

ttggagaaag cagttaagct ggcagcgaag cagggtgcac atatcattgt gaccccagaa      240

gatggaatct atggttggat cttcaccagg gagagcattt acccctatct agaggatata      300

ccagaccctg gagtgaactg gattccatgt agagacccct ggagattcgg caacacacca      360

gtgcaacaaa gactcagctg cctggccaag gacaactcta tctatgtcgt ggctaatatt      420

ggggacaaga agccatgcaa tgccagtgac tctcagtgtc cccctgatgg ccgttaccaa      480

tacaacactg atgtggtgtt tgattctcag ggaaaactgt tggcacgcta ccataagtac      540

aatctttttg cacctgaaat tcagtttgat ttccccaagg attcagaact tgtgactttt      600

gacactccct ttgggaagtt tggcattttt acttgctttg acattttttc tcatgaccca      660

gctgtggtgg tggtggatga gtcaattgac agcattctct accccacagc atggtacaac      720

acgctgcccc tcctctcggc tgttcccttc cattcagcat gggccaaggc catgggagtc      780

aatctacttg ctgcaaatac ccacaacacc agcatgcaca tgacagggag tggaatctac      840

gccccagaag cagtcaaggt gtaccactat gacatggaaa cagagagtgg tcagctgttg      900

ctatcagaac tgaagtctcg gccccgccgt gagcccacct accctgcagc tgttgactgg      960

catgcgtatg ccagcagtgt caagccattt tcctctgaac agtcagattt tctggggatg     1020

atttattttg atgagtttac cttcaccaag cttaagagaa atacaggaaa ttacacagct     1080

tgccagaaag atctgtgttg tcacttaact tacaagatgt ctgagaagcg aacagacgag     1140

atctatgccc taggtgcttt tgatggactg cacacagtag aaggccaata ttacttacag     1200

atatgtgcat tactgaagtg tcaaaccact gacctggaaa cgtgtggaga acctgtgggg     1260

tcagctttta ccaagtttga agacttctcc ctcagtggca catttggaac gcgttatgtt     1320

ttcccacaga tcattctaag tgggagtcag cttgcccctg aaagacatta tgagatttca     1380

agagatggac gcttgaggag ccgaagtgga gcccctttgc ctgtcttagt tatggccctg     1440

tatggaagag tgtttgagaa ggaccctcca cgcttagggc agggatctgg gaaattccag     1500

tga                                                                   1503


<210>  1415
<211>  9288
<212>  DNA
<213>  homo sapiens

<400>  1415
atggttttcg agtcggtggt cgtggacgtg ttgaaccggt tcttggggga ctatgtggtg       60

gacttggaca cgtcccagct ctctctgggc atctggaaag gagctgtggc cctcaagaat      120

cttcaaatta aagaaaatgc cctgagtcaa ctggatgtac catttaaagt taaagttggt      180

cacataggta atcttaaact tataattcca tggaaaaacc tttatactca acctgttgaa      240

gccgtattgg aagaaattta tttacttata gtgccttctt ctagaataaa atatgatcct      300

ttaaaagaag agaaacaact catggaagca aagcaacagg aactgaaaag aatagaagaa      360

gcaaaacaaa aagtagttga tcaagaacaa catctgccgg aaaaacagga cacttttgca      420

gaaaaattag ttacacagat cataaaaaat cttcaggtga aaatttccag tatccatatt      480

cgttatgaag atgatatcac aaatcgggac aaaccgctgt catttggtat ttcccttcaa      540

aatctgagca tgcagacaac tgatcaatac tgggttccat gtttacatga tgaaactgag      600

aaactggttc gtaagttaat ccgattggat aacctgtttg cctattggaa tgtgaagtct      660

cagatgtttt atcttagtga ttatgataac tccttggacg acttgaagaa tggcattgtc      720

aatgaaaata ttgttccaga aggttatgat tttgtatttc gtcccatatc tgctaatgcc      780

aaacttgtga tgaatcgccg atctgatttt gacttttctg cccccaaaat aaacttggaa      840

attgagttac ataacatagc aattgaattt aataaaccac agtatttcag tattatggag      900

cttcttgaat cagttgatat gatggcacaa aatctgccat ataggaagtt caaacctgat      960

gtgcctcttc accaccatgc cagagaatgg tgggcttatg ctatacatgg cgttcttgaa     1020

gtaaatgttt gccccaggtt atggatgtgg tcatggaagc atattagaaa acataggcaa     1080

aaagtgaagc aatataaaga actgtataaa aaaaagttaa caagtaagaa gccacctggt     1140

gaacttctcg tgtctttgga ggagttggaa aaaaccttgg atgtctttaa tataactata     1200

gctagacaga cggcagaagt tgaggtaaag aaagctggat acaaaattta caaagaagga     1260

gtaaaagatc cagaggataa taaagggtgg tttagctggc tatggtcttg gtcagaacaa     1320

aatactaatg aacagcaacc agatgttcaa cctgaaactc ttgaagaaat gttgacacct     1380

gaagaaaaag ctttactcta tgaagcaatt ggctatagtg aaacagcagt tgatccaact     1440

ttactaaaaa catttgaagc cttgaagttt tttgtccact tgaaaagtat gtctattgtt     1500

ctaagagaaa atcatcaaaa acctgagctg gtagatattg taatagaaga atttagcacc     1560

ttaattgtgc aaagaccagg agcacaagca ataaaatttg aaactaaaat agattcattt     1620

catattactg gcttaccaga taattcagaa aaaccccgcc tcctgtcttc attggatgat     1680

gcaatgtcac ttttccaaat tacatttgag ataaatccat tagatgaaac tgtttctcag     1740

aggtgtatca tagaagctga acctttagaa atcatatatg atgcaaggac agtgaatagt     1800

atagtggaat tcttcagacc tccaaaagag gtacatctag cacagctcac tgcagcaact     1860

ttgacaaaac tggaagaatt tcgcagtaag acagcaacag gtctactgta tattattgaa     1920

acacagaaag ttcttgatct caaaattaat ttgaaggctt catatattat tgtcccacaa     1980

gatggaattt ttagtcctac atcaaatctg cttcttttgg accttggtca tctaaaggtg     2040

acgagtaaaa gtcgttctga attaccagat gtgaaacaag gtgaggccaa tcttaaagag     2100

ataatggata gagcttatga ttcatttgat attcaactta caagtgtaca gctgctttac     2160

agtagagttg gtgataattg gagagaagca cgaaaactca gtgtatctac ccagcatatt     2220

ttggtaccca tgcacttcaa tttggaactg tctaaggcca tggttttcat ggatgtaagg     2280

atgcccaaat tcaagattta tggaaagtta cctcttattt ctttacgaat ctcagataaa     2340

aaactacaag ggattatgga attgattgaa agcattccaa aacctgaacc agtaactgaa     2400

gtatctgccc ctgtcaaatc attccagatt caaacatcta cttctttggg aacatcacag     2460

atttcacaga aaataattcc tctcttggaa cttccatctg tttctgaaga tgattcagag     2520

gaggaatttt ttgatgcacc atgtagtccc ttggaagaac ctcttcagtt tccaactgga     2580

gttaaaagta ttcgaaccag aaagttacaa aagcaggatt gttcagtaaa tatgactaca     2640

tttaaaataa gatttgaagt accaaaggtt ttgatcgagt tttatcacct tgttggagat     2700

tgtgaactat ctgtggtaga aattcttgtt ttaggattgg gtgcagaaat tgagattaga     2760

acatacgatt tgaaagcaaa tgcctttttg aaagagttct gcttaaaatg cccagaatac     2820

ttggatgaaa acaagaaacc agtttatttg gttacaaccc tggataacac aatggaagac     2880

ctgttaacgc tggaatatgt aaaggctgaa aagaatgtac ccgacttgaa aagtacctat     2940

aacaatgttt tacaattgat taaggtaaat ttttcctctt tggatattca tttacacact     3000

gaagcacttc tgaatacaat aaattatctt cataatatcc ttccgcaatc agaggaaaaa     3060

tcagccccag tgtccactac agagactgaa gacaaaggag atgtcattaa aaaattagct     3120

ttaaaactat ccacaaatga agatatcatt actttgcaga ttttagcaga attatcgtgt     3180

ttacagatct ttattcaaga tcagaaatgt aacatttctg aaattaagat tgaagggctt     3240

gattctgaga tgattatgag gccttcagaa actgaaataa acgcaaagct aaggaatata     3300

attgttttag attctgatat aacagctata tacaaaaagg ctgtttatat cactggaaaa     3360

gaagttttca gcttcaaaat ggtttcttac atggatgcaa ctgctggttc tgcatacaca     3420

gatatgaatg tggttgacat tcaggttaat ttaatagttg gttgcattga agtagttttt     3480

gtcacgaaat ttctatattc tatattggct tttatagata attttcaggc agctaaacaa     3540

gccttggctg aggcaactgt tcaggcagct ggaatggctg ctactggtgt aaaagaactc     3600

gcacaaagga gttccagaat ggcactggat attaacatca aagccccagt tgtggtcatc     3660

ccgcagtctc cagtttctga aaatgttttt gttgctgatt ttggactaat tacaatgaca     3720

aatacctttc atatgataac agagagccag agctctcccc cacctgttat tgatttgata     3780

acaataaagc tgagtgaaat gcgactatac agatctcgat ttattaatga tgcataccag     3840

gaagtactgg atctactcct gccattaaat cttgaggttg tggttgaacg aaatttatgc     3900

tgggagtggt accaggaagt tccttgtttt aatgtaaatg ctcagctgaa accaatggag     3960

ttcattctta gtcaagaaga tataacaact atttttaaaa cattgcatgg caatatatgg     4020

tatgaaaaag atggtagtgc ctcacctgct gtaacaaaag accaatacag tgccactagt     4080

ggagttacta ctaatgcttc acaccattca ggaggagcaa ctgtggtgac agctgctgtg     4140

gtagaagtac attcacgtgc cttactagtt aagacaacac taaacataag cttcaaaact     4200

gatgatctca ccatggtgct gtatagtcca ggtcctaaac aggcttcctt tacagatgtt     4260

cgtgatcctt ctctgaaact tgctgaattt aaattggaga atattataag tactttaaaa     4320

atgtatacag atggctcaac attttcttcc ttctcattaa aaaactgtat tttagatgat     4380

aaaagacctc atgtcaagaa agcaactcct cgaatgatag gactgacagt tggttttgac     4440

aaaaaagaca tgatggatat aaagtacagg aaagtcagag atggttgtgt gactgatgcg     4500

gtctttcaag aaatgtatat ttgtgcaagc gtagaatttc tgcagactgt tgcaaatgtc     4560

tttcttgagg cctacaccac aggcactgct gtagaaacca gtgtgcaaac atggactgct     4620

aaggaagaag tacctacaca ggaatcagtg aagtgggaaa ttaatgttat tattaaaaat     4680

cctgaaattg tgtttgtagc tgacatgaca aaaaatgatg ctcctgcttt agtcattaca     4740

acacaatgtg aaatttgcta taaaggtaac cttgaaaata gtacaatgac tgctgccatt     4800

aaagatctcc aagtgagagc ctgcccgttt cttccagtca agagaaaagg caaaatcact     4860

actgttttgc agccctgtga cttgttttat caaactactc agaaaggtac agatccacaa     4920

gtgatcgata tgtcagtaaa atccctgaca ctaaaggttt caccagttat tataaatact     4980

atgattacca taacttcagc actgtataca actaaggaaa ccatcccaga agaaacggct     5040

tcttctactg cacatttatg ggaaaagaag gatacaaaga ctttaaaaat gtggtttctt     5100

gaagaatcaa atgaaactga aaaaatagct cccacaactg aattggtacc caaaggcgag     5160

atgataaaaa tgaacattga ttctattttt atagttcttg aggctggaat tggtcataga     5220

acagtaccta tgcttctggc aaagtcacgt ttttcagggg aaggcaaaaa ctggagttcc     5280

ctaataaatc tgcactgtca gcttgagcta gaagtgcatt attataatga aatgtttggt     5340

gtatgggagc ctttgcttga acccttagaa attgatcaga ctgaggattt tagaccatgg     5400

aatcttggta tcaagatgaa aaagaaagca aaaatggcca ttgttgagtc agatcctgaa     5460

gaagaaaact acaaagtgcc agaatataaa actgtcatca gtttccattc aaaagaccaa     5520

ttaaacatta cattatccaa atgtggtctt gtaatgttaa acaatttagt caaggcattt     5580

acagaagctg ccactggatc ttcagctgac ttcgtaaagg atctagcacc atttatgatt     5640

ttaaattccc ttggacttac tatttctgtt tcgccaagtg attcttttag tgtactcaac     5700

attcctatgg caaaatcata tgtattgaaa aatggagaaa gtttaagtat ggattatatc     5760

cgaaccaagg acaatgatca tttcaatgca atgaccagcc taagcagcaa actcttcttc     5820

attcttctta cacctgttaa ccattctact gctgataaga ttcctttaac aaaagtggga     5880

cgacgtctgt acactgtaag acacagagag tctggcgttg aaagatctat tgtttgtcaa     5940

attgatacag tagaaggaag taagaaggtc acaattcgct ccccagtgca gataagaaat     6000

catttttcag tcccactgtc tgtttacgaa ggggatacct tattgggaac tgcctcacct     6060

gaaaatgaat tcaacatacc attaggatct taccgatcat tcatttttct gaagccagaa     6120

gatgagaact atcaaatgtg tgaaggaatt gactttgaag agattataaa aaatgatggt     6180

gctcttctaa agaagaaatg tagatctaaa aacccttcta aggaatcatt tctcattaat     6240

attgttccag aaaaagataa tttaacatct ctatcagtgt attcagaaga tggttgggat     6300

ttaccataca taatgcattt gtggccacct atcctgctcc gaaatcttct tccttacaaa     6360

attgcttatt atatagaggg aattgaaaat tcggttttta ctctaagtga aggacattca     6420

gcccagattt gtactgcaca gttgggtaaa gccaggctac atttaaaatt acttgactat     6480

ctcaatcacg attggaaaag tgaatatcac ataaagccta atcagcaaga cattagtttt     6540

gtcagtttta cttgtgttac agaaatggaa aagactgatt tagatattgc tgtccatatg     6600

acttacaata ctggtcagac agttgtggca tttcatagtc cttattggat ggtcaataaa     6660

actggccgca tgttacagta caaagcagac ggaattcatc gaaagcatcc acctaattat     6720

aaaaagccag ttctcttttc ttttcagcca aatcactttt ttaataacaa taaggttcaa     6780

cttatggtaa ctgatagtga gttgtccaat cagttttcaa ttgatactgt tggtagtcat     6840

ggagctgtta aatgtaaagg cctgaaaatg gactatcaag ttggtgtcac tatagacctg     6900

agcagtttta acattactag aattgtgaca tttacccctt tttatatgat taaaaacaaa     6960

agcaaatacc atatatcagt ggctgaagaa ggaaatgata aatggctctc tcttgatttg     7020

gagcagtgta tccccttttg gcctgagtat gcttctagta aacttcttat tcaagtcgaa     7080

aggagtgaag atcctcccaa aaggatatat tttaacaagc aggaaaattg tattctattg     7140

cgtctagata acgagcttgg aggtattata gcagaagtga atttggccga gcattctaca     7200

gttattacat ttttagatta tcatgatgga gcagctacat tcctcttaat aaatcacaca     7260

aagaatgaac ttgttcaata caatcaaagt tctctcagtg aaatagaaga ttccctccct     7320

cctggtaaag ccgtgtttta tacatgggct gatccggtgg gctctagaag gctgaagtgg     7380

agatgtagaa aaagccatgg tgaagtaaca cagaaggatg atatgatgat gcctatagat     7440

ttgggggaaa agacaatata tttagtttca ttctttgaag gtttacaacg cattatttta     7500

ttcactgaag atccaagggt atttaaagta acatatgaaa gtgagaaagc agagttagca     7560

gagcaagaaa ttgcagtggc attacaagat gttggaattt ctcttgtcaa caattacacg     7620

aagcaagaag tagcctatat aggcattaca agttctgatg tggtttggga aacaaagccc     7680

aagaagaagg caagatggaa gccaatgagt gtaaagcaca ctgagaagtt agagagagaa     7740

tttaaggaat atactgaatc ttctccttca gaagataagg ttattcagtt ggacactaat     7800

gttccggttc gcctaacccc tactggtcat aacatgaaaa ttctgcagcc gcatgtaata     7860

gctctacgaa gaaattatct tccagcatta aaagtggaat ataacacatc tgcacatcaa     7920

tcatcattta gaattcagat ttacagaata cagatccaaa atcagataca tggtgctgta     7980

tttccctttg tgttttatcc tgttaaacct ccaaagtcgg tcaccatgga ttcagcacca     8040

aagcccttta cagatgtcag tattgtcatg agatctgcag gacattccca gatatcacgt     8100

attaagtatt tcaaagtatt gattcaagaa atggatctca ggttagatct tgggtttatc     8160

tatgctttaa cagaccttat gacagaagct gaggtgactg aaaatacaga ggttgagctt     8220

tttcataaag atatagaagc tttcaaagaa gaatataaaa cagcctcatt agtagatcaa     8280

tcacaagtca gcctctatga atattttcat atatctccta tcaagttaca tttaagtgtt     8340

tcactgagtt ccggcagaga agaagctaaa gattcaaaac aaaatggagg actgattcca     8400

gttcattctt taaatctttt gctgaagagt attggtgcca cactgacaga tgtacaagat     8460

gtagttttta agcttgcatt ttttgaactc aactatcagt tccatacaac atccgatcta     8520

cagtctgaag tcataagaca ctattcaaaa caggccatta agcagatgta tgtactcatt     8580

cttggacttg atgttttggg aaatccattt ggcttaatta gagaattttc tgaaggtgta     8640

gaagcatttt tttatgaacc ttaccaggga gccatccagg gtcctgaaga gtttgtggaa     8700

ggaatggcac taggacttaa ggcactagtt ggtggagctg ttggtggatt ggctggtgct     8760

gcctccaaaa tcaccggtgc tatggctaag ggggtagcag ctatgaccat ggatgaagac     8820

taccaacaga agagaagaga agccatgaat aagcaaccag ctggttttag agaaggcatc     8880

actcgtggag gaaaaggctt agtttctgga tttgttagtg gcataacagg aattgttaca     8940

aaaccaatca aaggagctca aaaaggagga gcagctggtt tctttaaagg tgttgggaaa     9000

ggtttagtag gagcggtagc aaggccaact ggaggcatca tagacatggc tagcagtaca     9060

tttcagggaa taaaaagagc tacagagact tctgaagtgg agagtctgcg acctcctcgg     9120

ttcttcaatg aagatggagt tatcagaccg tacaggttga gggatgggac tggaaatcaa     9180

atgttacaga aaattcaatt ctacagggag tggattatga ctcacagtag cagtagtgat     9240

gatgatgatg atgatgatga tgatgatgag tcagatctaa accattaa                  9288


<210>  1416
<211>  2592
<212>  DNA
<213>  homo sapiens

<400>  1416
atgctggagt catatgtaac tccaatttta atgagctatg tgaatcgcta catcaagaac       60

ttaaagccgt cggatctaca gctttcacta tggggtggag acgtggtact cagcaagctc      120

gagttaaagt tggatgtgct ggaacaggaa ctgaaattac cattcacttt tttaagtgga      180

catattcatg aattgaggat tcatgtacca tggacaaaac tgggttcaga accagtggta      240

attaccatca atactatgga atgcattttg aaacttaagg atgggataca ggatgaccat      300

gaaagctgtg gttctaattc taccaaccgt agtactgctg agagcacaaa atcatcaatc      360

aaaccgcgga gaatgcagca ggctgctcct acagatcctg acttaccacc aggttatgtg      420

cagagtctga ttagacgagt tgtaaataat gtaaacattg tgataaataa tctcatacta      480

aaatatgttg aagatgatat cgtcctttcc gtcaatatca cttctgcaga atgttataca      540

gtaggtgaat tatgggatcg tgcattcatg gatatttctg caactgattt ggtgctgaga      600

aaggttatca atttttctga ctgtacagtt tgtcttgata aacggaatgc cagtggtaaa      660

atagaatttt accaggatcc tttattatac aaatgttcct tcagaactcg tcttcatttt      720

acatatgaaa acctaaattc caagatgcca tctgttatta aaattcatac tttagtggaa      780

agtttgaaac tttctatcac agatcaacaa ctgcctatgt ttattcgtat aatgcaactt      840

ggaattgctc tttactatgg agaaataggc aattttaaag aaggcgaaat agaggacctt      900

acttgtcata ataaagatat gctaggaaac attacaggtt ctgaagatga aacaagaata      960

gatatgcaat atcctgctca gcataaaggt caagagttat attcacagca agatgaggag     1020

cagccacagg gatgggtgtc atgggcctgg tcctttgtgc ctgcaattgt gagttatgac     1080

gatggcgagg aagactttgt tgggaacgat cctgcatcaa ccatgcatca acaaaaagca     1140

cagactttga aggatcctat tgtttctata ggattttatt gcacaaaggc aacggtgact     1200

ttcaaactca cagaaatgca agttgagagt agttattaca gtccacagaa agtaaaatct     1260

aaagaagtat tgtgttggga acaagaagga actacagttg aggcccttat gatgggagaa     1320

cctttctttg attgccagat tgggtttgtt ggttgcagag ccatgtgcct taaaggaatt     1380

atgggtgtta aagattttga agagaatatg aatagaagtg aaactgaagc ctgtttcttc     1440

atttgtggtg acaatttgag tacgaaaggt ttcacatacc ttacaaattc attgtttgat     1500

taccgaagcc cagaaaataa tggtactcgc gcagaattta tcttggattc aactcatcat     1560

aaggagacat acactgagat agctggaatg caacggtttg gggcttttta tatggattac     1620

ctgtatacaa tggagaacac tagtggcaaa ggttccacaa atcaacaaga cttttcttca     1680

gggaaaagtg aagatttggg aacagttcag gagaagtcca ccaaaagcct tgttataggt     1740

cctcttgatt ttcgtttgga tagcagtgcg gtgcatagga ttttgaaaat gattgtgtgt     1800

gccttggaac atgaatatga accatatagc aggctaaaat cagatattaa ggatgaaaat     1860

gaaacaatac tgaatcctga agaggtggct cttctggagg aatatattcc tactcgacat     1920

acaagtgtta ctctcctcaa atgtacctgc acaatttcca tggctgaatt caacttgctg     1980

gaccatttac tacctgtcat tatgggagaa aagaactcaa gtaacttcat gaatactaca     2040

aacttccagt ctcttcggcc tttgccatcc attcgaatat tggtggataa aattaatctg     2100

gaacattcag tgccaatgta tgctgaacag ttggtgcatg tggtcagcag ccttactcaa     2160

ccttctgata acctgcttca ttattgttat gtacactgct atcttaagat atttggtttc     2220

caggcaggac tgacgtcttt ggattgcagt ggatcttact gcttacctgt accagttatt     2280

ccctctttca gcactgctct ttatgggaaa cttctgaaac tccccacatg ctggaccaaa     2340

agatctcaga ttgctataac tgaaggtata tttgaacttc caaatctcac aattcaagct     2400

acaagagcac agacacttct cttgcaagca atatatcaaa gttggtctca tcttggaaat     2460

gtcagctctt ccgcagtgat tgaagctttg ataaatgaaa tcttcctaag tatagagatt     2520

gggtcttgct atgttgccca ggttgatctt gaactcctgg cctcaaatga tcctcccacc     2580

tcaacctcct ga                                                         2592


<210>  1417
<211>  11133
<212>  DNA
<213>  homo sapiens

<400>  1417
atggtgctgg agtcggtggt cgcggacttg ctgaaccgct tcctggggga ctatgtggag       60

aacctgaaca agtcccagct gaagctgggc atctggggcg gaaatgtggc tttagataat      120

ctacagataa aagaaaatgc cctgagtgaa ttggatgttc cttttaaagt caaggctggc      180

caaattgata aattaacttt gaagattcct tggaagaacc tttatggaga agcagttgtt      240

gcgaccctgg aaggattata cctgcttgtt gtccctggag caagtattaa gtatgatgct      300

gtaaaagaag aaaaatcctt gcaggatgtt aaacagaaag agctatcccg aattgaagaa      360

gcccttcaaa aagcagcaga aaaagataag ccaaaagaag ccaaaaagga tacatttgtg      420

gaaaaattgg caactcaagt aataaaaaat gtacaagtaa aaatcacaga tattcacatt      480

aaatatgaag atgatgtcac tgatccaaag cggcctcttt catttggtgt cacactggga      540

gagcttagtc tactgactgc aaatgaacac tggactccat gcatattaaa tgaagcagac      600

aaaattatat acaagcttat acgacttgat agtcttagcg cctactggaa tgtaaattgc      660

agcatgtctt accagagatc aagggaacag attttggatc agctgaaaaa tgaaattctt      720

acaagtggaa atataccccc aaattatcaa tacattttcc agccaatatc agcctctgca      780

aaactctaca tgaatcctta tgcagaatca gagctcaaaa cgcccaaact ggattgcaac      840

atagaaatac aaaatattgc cattgaactg accaaacctc agtacttaag tatgattgac      900

cttttggagt cagtggatta tatggttagg aatgcgcctt ataggaaata caagccttat      960

ttaccacttc ataccaatgg tcgacgatgg tggaaatatg caattgattc tgttcttgaa     1020

gttcatataa gaaggtatac acagatgtgg tcatggagta acataaaaaa gcacaggcag     1080

ttactcaaga gttataaaat tgcctacaaa aacaagttaa cacagtctaa agtctcagaa     1140

gaaatacaga aagaaattca ggacttggag aagactctag atgtttttaa cataatttta     1200

gcaaggcaac aagcacaagt tgaggtgatt cggtctgggc aaaaattaag gaaaaagtct     1260

gctgacacag gcgagaaacg tggaggctgg tttagtgggt tgtggggtaa gaaagagtct     1320

aagaaaaagg acgaagaatc attgattcct gaaactattg atgaccttat gactccagag     1380

gaaaaagata aactcttcac tgccattggt tatagtgaga gtacccacaa cctaacttta     1440

cctaagcagt atgttgccca tattatgacc ctgaagttag taagcacctc tgttacgata     1500

agagaaaaca agaatattcc agaaatacta aaaattcaga taattggcct gggcactcaa     1560

gtatctcagc gaccaggagc acaagcactt aaggtagaag cgaaattaga acactggtat     1620

ataacaggtt tgagacagca ggatattgtg ccatcacttg tggcttcaat tggtgacact     1680

acatcatcct tgcttaaaat taaatttgaa accaatccgg aggatagtcc tgctgaccag     1740

actctgattg ttcagtccca gcctgtggag gtcatctatg atgctaaaac tgtcaatgca     1800

gtggttgaat tctttcaatc aaataaggga ttggatcttg agcaaataac atcagcaaca     1860

ttgatgaagc tggaagaaat taaggagaga acagctacag gacttacaca tattattgaa     1920

actcgaaaag tccttgattt aaggataaat ctgaagcctt cttatctagt agttccacag     1980

acgggtttcc accatgaaaa gtcagatctt ctgattttag attttggtac atttcagctc     2040

aacagtaaag atcaaggttt acagaagact actaattcat ctctggaaga aataatggat     2100

aaggcatatg acaagtttga tgttgaaata aaaaatgtac aactactttt tgcaagagca     2160

gaggaaacct ggaaaaagtg tcgatttcag catccatcaa ctatgcatat attgcaaccc     2220

atggatattc atgttgagtt ggctaaggcc atggtagaaa aagacattag aatggccaga     2280

tttaaagtgt caggaggact tcctttgatg catgtgagaa tttctgacca gaagatgaaa     2340

gatgtgctat atttgatgaa cagtatacct ttgccacaga aatcatcagc ccagtctcca     2400

gagagacagg tatcctcaat tcctattatt tcaggtggta caaaaggtct acttggtact     2460

tcactattgc tagacactgt ggaatcagag tctgatgatg agtattttga tgctgaagat     2520

ggagaaccac agacttgtaa aagtatgaaa ggatcagaac ttaaaaaagc tgcagaggtc     2580

ccaaatgagg agctcatcaa tcttctactc aagtttgaaa ttaaagaagt gattttggaa     2640

tttactaaac agcagaaaga agaagataca attctagtat ttaatgttac tcagttagga     2700

acagaggcca caatgagaac atttgactta actgtggtat cttatttaaa gaaaatcagc     2760

ttggattatc atgaaattga aggatccaaa aggaagcccc ttcacttgat tagctcttct     2820

gacaaacctg gattagatct tttgaaagtg gagtatatta aggctgataa gaatggacct     2880

agttttcaaa ctgcttttgg aaaaactgaa caaacagtta aggtggcctt ttcatcttta     2940

aatctgttgc tgcaaacaca agctcttgtc gcttctatta attacctcac aaccattatt     3000

ccatctgatg atcaaagcat aagtgttgct aaggaggtac aaatttcaac tgaaaaacaa     3060

caaaaaaatt caactctgcc aaaagcgatt gtatcctcca gagatagtga cattattgat     3120

ttcaggctat ttgccaagtt gaatgctttc tgtgtcattg tttgcaacga aaagaacaat     3180

atcgccgaaa tcaagattca aggactggat tcctcccttt ctctccagtc aagaaagcag     3240

tcactttttg cccgactaga aaatattatt gtcacagatg ttgatccaaa gacagttcat     3300

aagaaagctg tgtcaataat gggaaatgaa gttttccgtt ttaatttgga tttgtatcca     3360

gatgctactg agggggattt gtatactgac atgtccaaag tggatggtgt gctgtctctg     3420

aatgttggct gtattcagat tgtctatctt cataaattcc ttatgtcact tctgaacttc     3480

ctgaataatt tccagacagc caaagagtct ctgagtgctg ccactgccca ggctgcagaa     3540

agggctgcca caagtgtgaa agatcttgcc cagaggagtt ttcgtgtttc catcaatatt     3600

gatttgaaag caccggttat agtcatccca cagtcttcta tttccaccaa tgcagtagtg     3660

gtagatcttg ggttaatcag agttcataat cagttcagtc tggtgtctga tgaagactac     3720

ttaaatcctc cagtaattga tagaatggat gtgcagctaa caaagcttac actttatagg     3780

acagtgatcc agccaggcat ctaccatcct gatattcagc tgttgcaccc aattaacttg     3840

gaatttcttg taaatcggaa tctagctgca tcttggtacc acaaggtgcc tgttgtggaa     3900

attaaaggac atcttgattc aatgaatgtt agtctaaatc aagaagatct taatctttta     3960

tttaggatac taacagaaaa tctctgtgag ggtactgaag acttggataa agtgaaacca     4020

agagtacaag agacaggtga aattaaagag ccccttgaaa tctctatatc acaagatgta     4080

catgattcaa aaaatacttt aacaactgga gtggaagaaa ttaggtctgt agacatcatt     4140

aatatgctgc tgaattttga aattaaagag gttgtggtta ctttgatgaa aaaatcagaa     4200

aagaaaggaa ggcctttaca tgagctaaat gtcctgcaac ttggaatgga agctaaagtt     4260

aaaacctatg acatgactgc taaagcttat ctaaaaaaaa ttagtatgca gtgctttgat     4320

ttcactgact ctaaagggga acctcttcac attattaact cttctaatgt gactgacgaa     4380

ccccttctga aaatgttact gacaaaggca gacagtgatg gaccagaatt taaaactatt     4440

catgacagta ccaaacagag actgaaggtt tcatttgcat ccttagactt agtacttcat     4500

ttggaagctt tactttcctt catggatttt ttatcatctg ctgctccatt ctctgagcct     4560

tcctcttctg agaaggaatc cgagctgaaa ccacttgtgg gggagtccag aagtatcgct     4620

gtcaaagctg tatccagcaa catttcccaa aaggatgtgt ttgatttaaa gatcacagct     4680

gaattaaatg catttaatgt ctttgtctgt gatcagaagt gtaacattgc agatattaaa     4740

atacatggaa tggatgcctc tatttctgtg aagcctaagc agactgatgt gtttgccaga     4800

cttaaagata ttatagttat gaatgtagat ttgcagtcca ttcacaaaaa ggctgtctct     4860

attttgggag atgaagtctt taggttccaa ctgactcttt atccagatgc cacagaagga     4920

gaggcctatg ctgatatgtc caaagtagac ggcaaactta gttttaaagt gggttgtatt     4980

cagattgttt atgttcataa attcttcatg tctcttttga acttcctcaa caatttccaa     5040

actgctaaag aagctttgag tacagccaca gtccaggctg cagaaagagc tgcttccagc     5100

atgaaagact tggctcaaaa gagtttccgc cttttgatgg atattaattt gaaagcacca     5160

gttattatta ttcctcagtc ttcagtatca cctaatgctg ttatagcaga tctgggttta     5220

atcagagttg aaaacaagtt tagcttggtt cctatggaac attattctct tcctccagtc     5280

attgataaaa tgaacatcga actcactcag ttgaagctgt caagaactat tttgcaggct     5340

agcttgccac aaaatgacat tgaaatttta aaaccagtca acatgctttt gtccatacag     5400

cgaaacttag cagcagcatg gtatgtgcaa attccaggga tggagataaa aggaaaacta     5460

aaacctatgc aggttgctct cagtgaagat gacttgacag ttttaatgaa aattttgcta     5520

gaaaatcttg gagaagcttc ctcacaacca agccctacac agtctgtgca ggagactgta     5580

agagtgagaa aagttgatgt ttcaagtgta cctgaccatc tcaaagaaca agaagattgg     5640

acagactcaa agctctctat gaaccagatt gtcagtctcc aatttgactt tcactttgaa     5700

tctctttcca ttatccttta taacaatgat atcaaccagg aatctggagt tgcatttcat     5760

aatgacagtt tccaacttgg tgaactcaga ctacatctta tggcctcctc agggaagatg     5820

tttaaggatg gctcaatgaa tgtcagcgtt aaacttaaga catgcaccct tgatgatctc     5880

agagaaggaa ttgagagagc aacatcgaga atgattgaca gaaagaatga ccaagataac     5940

aacagttcta tgattgatat aagttacaaa caagacaaaa atggaagtca aattgatgct     6000

gttcttgaca agctgtatgt atgtgccagt gtggaatttc tgatgactgt ggcagatttc     6060

tttatcaaag ctgtgcctca gagtccagaa aatgtggcaa aagaaacaca gattttacca     6120

agacagactg ccacagggaa ggtcaagata gagaaagatg actctgttag accaaatatg     6180

actttaaagg ccatgatcac agatccagaa gtggtatttg ttgccagcct gacaaaggct     6240

gatgctcctg ctctgacagc ctcgtttcag tgcaaccttt ctctgtcaac atccaaactc     6300

gaacagatga tggaagcttc tgtgagagat ctgaaagtgc tcgcttgccc ttttctcaga     6360

gaaaagagag ggaaaaacat taccacagtc ttgcagccct gttctttatt tatggaaaaa     6420

tgtacgtggg cttcaggaaa gcaaaatata aatattatgg ttaaagaatt tataattaag     6480

atttcaccca taattcttaa tactgtgttg acaatcatgg ctgcattgtc tccaaaaaca     6540

aaagaagatg gatccaaaga tacgtctaag gaaatggaaa atctttgggg tatcaaatcg     6600

attaatgatt ataacacttg gtttcttggt gttgacacgg caacagaaat aacggaaagc     6660

ttcaaaggca ttgaacattc actgatagag gaaaattgtg gtgttgttgt agaatccatt     6720

caagttacct tagaatgtgg ccttggacat cgaactgtac ctttattatt ggcagagtct     6780

aagttttcag gaaatattaa aaattggact tctctaatgg ctgctgttgc tgacgtgaca     6840

ctacaggtgc actattacaa tgagatccat gctgtctggg agccactgat tgagagagtg     6900

gaggggaaga gacaatggaa tttaaggctt gatgtaaaga agaacccagt tcaggataaa     6960

agtttgctgc caggagatga ttttattcct gagccacaaa tggcaattca tatttcttca     7020

ggaaatacaa tgaatataac aatatccaaa agttgtctta atgttttcaa caatttagca     7080

aaaggttttt cagagggcac tgcttctact tttgactact ctttaaagga cagagctcct     7140

tttacggtaa aaaatgctgt aggtgttccc attaaggtga agcccaattg taatctcaga     7200

gtaatgggct tccctgagaa aagtgatatt tttgatgttg atgctggcca gaatttggaa     7260

ctggagtatg ccagcatggt accttcaagt caagggaacc tatctatatt gagccgtcaa     7320

gaaagctcct tcttcactct gaccattgta cctcatggat atacagaagt tgcaaatatc     7380

cctgtggcca gacctggacg gcgattgtat aatgtacgga atcccaatgc cagtcattct     7440

gactctgtct tggtacaaat tgatgcaact gaagggaata aagtaattac ccttcgctct     7500

cctctacaga tcaaaaacca tttctccatt gcatttatca tctataaatt tgttaagaat     7560

gttaagctat tggagcgcat tgggatagcc agacctgaag aggagttcca tgttccttta     7620

gattcatata gatgtcaatt gtttatccag ccagctggaa tcttagagca tcagtacaaa     7680

gaatctacca cttatatttc ctggaaggaa gaacttcata ggagcaggga agtcagatgc     7740

atgttgcagt gtccatcagt agaagtcagc ttcttacctc tcatagtgaa tacagttgct     7800

ctgcctgatg aattgagcta catatgtaca catggggaag actgggatgt agcttacatt     7860

attcatcttt atccttctct cactttgcgg aatcttctcc catattccct aagatattta     7920

cttgagggaa cagcagaaac tcatgagctg gcagaaggca gtactgctga tgttctgcat     7980

tcgagaatca gtggtgaaat aatggaatta gtcctggtga aataccaggg caaaaactgg     8040

aatggacatt tccgcatacg tgatacacta ccagaattct ttcctgtgtg tttttcttct     8100

gactccacag aagtgacgac agtcgacctg tcagtccacg tcaggagaat tggcagccgg     8160

atggtgctgt ctgtctttag tccctattgg ttaatcaaca agactacccg ggttctccag     8220

tatcgttcag aagatattca tgtgaaacat ccagctgatt tcagggatat tattttattt     8280

tctttcaaga agaagaacat ttttactaaa aataaggtac aattaaaaat ttcaaccagt     8340

gcctggtcca gtagtttctc attggataca gtgggaagtt atgggtgtgt gaagtgtcct     8400

gccaacaata tggagtacct ggttggtgtt agcatcaaaa tgagcagttt caacctttca     8460

cgaatagtta ccctgactcc cttttgtacc attgcaaaca agtcatcatt agaactagaa     8520

gttggcgaga ttgcatctga tggctcaatg ccaactaata aatggaacta tattgcttct     8580

tcagagtgcc ttccattttg gccagaaagt ttgtcaggca aactttgtgt gagagtggtg     8640

ggctgtgaag gatcttccaa accattcttt tataaccgac aggataatgg cactttattg     8700

agcttagaag atctgaatgg gggtatcttg gtggatgtaa acactgccga acattcaact     8760

gtcataactt tttctgatta ccatgaggga tctgcacctg ccttgataat gaaccataca     8820

ccatgggaca tcctcacata caaacagagt gggtcaccag aagaaatggt cttgctgcca     8880

agacaggctc gactttttgc ctgggcagat cctactggta ccagaaaact tacatggaca     8940

tatgcagcaa atgttgggga acatgatctg ttaaaggatg gatgtggaca gtttccatat     9000

gatgcaaaca tccagataca ctgggtatca tttctggatg ggcgccagag agttttgctt     9060

ttcaccgatg atgttgcctt ggtttccaaa gcactgcagg cagaagaaat ggaacaggct     9120

gattatgaaa taaccttgtc tctccacagt cttgggcttt cactggttaa caatgaaagc     9180

aagcaggaag tttcctatat tgggataacc agttctggtg ttgtttggga ggtgaaacca     9240

aagcagaaat ggaagccatt tagtcaaaag cagataatct tattggaaca atcctatcag     9300

aaacatcaaa tatcaagaga ccatggctgg attaagctag ataataattt tgaggtcaat     9360

tttgataaag atccaatgga aatgcgcctc cctattcgta gccctattaa acgagacttt     9420

ttatcaggaa ttcagattga atttaagcag tcttctcacc agagaagttt aagggccagg     9480

ttgtactggc ttcaggttga taatcagtta ccaggtgcaa tgttccctgt tgtatttcat     9540

cctgttgccc ctccaaaatc tattgcttta gattcagagc ccaagccttt cattgatgtg     9600

agtgtcatca caagatttaa tgagtacagt aaagtcttac agttcaagta ttttatggtc     9660

ctcattcagg aaatggcctt aaaaattgat caagggtttc taggagctat tattgcactg     9720

tttaccccaa caacagaccc tgaagctgaa agaagacgga caaagttaat ccaacaagat     9780

attgatgctc taaatgcaga attaatggag acttcaatga ctgatatgtc aattcttagt     9840

ttctttgaac atttccatat ttctcctgtg aagttgcatt tgagtttgtc tttgggttcc     9900

ggaggtgaag aatcagacaa agaaaaacag gaaatgtttg cagttcattc tgtcaacttg     9960

ctgttgaaaa gcataggtgc tactctgact gatgtggatg accttatatt caaacttgct    10020

tattatgaaa ttcgatatca gttctacaag agagatcagc ttatatggag tgttgttagg    10080

cattacagtg aacagttctt gaaacagatg tatgtccttg tattggggtt agatgtactt    10140

ggaaacccat ttggattaat tagaggtctg tctgaaggag ttgaagcttt attctatgaa    10200

cccttccagg gtgctgttca aggccctgaa gaatttgcag aggggttagt gattggagtg    10260

agaagcctct ttggacacac agtaggtggt gcagcaggag ttgtatctcg aatcaccggt    10320

tctgttggga aaggtttggc agcaattaca atggacaagg aatatcagca aaaaagaaga    10380

gaagagttga gtcgacagcc cagagatttt ggagacagcc tggccagagg aggaaagggc    10440

tttctgcgag gagttgttgg tggagtgact ggaataataa caaaacctgt ggaaggtgcc    10500

aaaaaggaag gagctgctgg attctttaaa ggaattggaa aagggcttgt gggtgctgtg    10560

gcccgtccaa ctggtggaat cgtagatatg gccagtagta ccttccaagg cattcagagg    10620

gcagcagaat caactgagga agtatctagc ctccgtcccc ctcgcctgat ccatgaagat    10680

ggcatcattc gtccttatga cagacaggaa tctgagggct ctgacttact tgagaatcat    10740

atcaaaaagt tggaaggaga gacttaccga taccactgtg ctattcctgg aagcaagaag    10800

acaatcctta tggttacaaa taggcgagtg ttgtgtataa aggaagttga aatcctgggc    10860

cttatgtgtg tagactggca atgtccattt gaagattttg tatttcctcc tagtgtcagt    10920

gaaaatgtgc taaaaatttc agttaaggaa cagggtctgt tccacaaaaa agacagtgcc    10980

aatcaaggct gtgttcgaaa agtttacctg aaggacaccg ccacagcaga gagagcatgt    11040

aatgccattg aggatgcaca gtcaacgaga cagcagcaaa aattgatgaa gcagtcatca    11100

gtgagacttc tcagacccca attgccatct taa                                 11133


<210>  1418
<211>  1965
<212>  DNA
<213>  homo sapiens

<400>  1418
atggagcgct ctgggcccag cgaagtgaca ggctcagacg cgtcgggacc ggacccgcag       60

cttgcggtca ccatgggctt cacggggttc ggtaaaaaag ctcgcacatt tgacttggaa      120

gcaatgtttg aacaaactcg aaggacagct gtggaaagaa gtcgcaaaac actggaagca      180

agagaaaaag aggaagaaat gaacagagag aaagaattaa gaagacaaaa tgaagatatt      240

gagccaacat cctcaagatc aaatgtggtc agagattgct ccaaatcatc ttccagggat      300

acgagcagca gtgaaagtga acagagttct gactcttctg atgatgagtt aattggccct      360

cctttacccc ctaaaatggt aggaaaacca gttaatttta tggaggaaga tatcctcggt      420

cctttacctc cacctcttaa tgaagaagaa gaagaagcag aggaagaaga agaggaagag      480

gaggaagagg aaaatcctgt tcacaagatt cctgactcgc atgagataac gctgaagcat      540

ggcactaaaa cagtgtctgc tttgggtctg gatccctcag gtgcccgttt ggtgacagga      600

ggatatgact atgatgttaa gttttgggat tttgctggaa tggatgcttc ttttaaggca      660

tttcgatccc ttcagccctg tgagtgccat cagatcaagt cattacagta tagtaacaca      720

ggagacatga ttcttgttgt atctggaagc tctcaggcca aggtgattga cagagatggt      780

tttgaagtaa tggaatgtat aaaaggagac cagtatattg tggacatggc caacaccaag      840

ggtcatacag caatgcttca tactggctca tggcatccca aaataaaggg agaatttatg      900

acttgctcaa atgatgcgac tgtgaggacg tgggaagttg aaaatccaaa gaagcaaaaa      960

agtgtgttta aaccacggac gatgcaaggc aaaaaagtca ttcccactac gtgcacatat     1020

agtagagatg gaaacctcat agcagctgcc tgccagaatg gaagcataca gatctgggac     1080

cgaaatttga ctgttcatcc taagttccac tataaacagg ctcatgactc gggcacagac     1140

acttcttgcg tgactttttc ctatgatggt aatgtccttg cctctcgtgg aggtgacgat     1200

tcattaaaat tatgggacat ccgacaattt aataaaccac ttttttcagc ctcgggtctt     1260

cccaccatgt tcccaatgac tgactgctgt ttcagtccag atgataagct catagtcact     1320

ggtacatcta ttcaaagagg atgtggcagc ggcaaacttg ttttctttga gcgtaggact     1380

ttccaaaggg tgtatgaaat agacatcaca gatgcgagtg ttgttcgctg cctgtggcat     1440

ccaaagctga accagatcat ggttggaact ggaaatggat tggctaaagt ctattacgac     1500

cccaacaaga gtcagagggg agcaaaatta tgtgtggtta aaacccagcg gaaggcaaaa     1560

caagctgaga ctctaactca ggactacatc atcacccctc atgccttgcc tatgttccgt     1620

gagccccgcc aacggagtac aaggaaacag ctggagaagg acagactgga tcccctgaag     1680

tcgcataaac ctgaacctcc tgtagcaggc ccaggtcgtg gtggccgagt tggaacccac     1740

gggggcactc tctcttccta tattgtgaag aacattgctt tggacaagac cgatgacagt     1800

aatcctcggg aagccatttt gcgtcatgcc aaagcagcag aagacagccc atattgggtt     1860

tctccagcat attccaagac tcagcccaaa accatgtttg cccaagttga atctgatgat     1920

gaggaagcaa agaatgagcc agaatggaaa aaacgtaaaa tttga                     1965


<210>  1419
<211>  3456
<212>  DNA
<213>  homo sapiens

<400>  1419
atgatggcgg cggcgctggg gcccccagaa gtgatcgctc agctggagaa cgcggctaaa       60

gttctgatgg caccaccttc catggtcaat aatgaacaac gccagcatgc agagcacata      120

ttcttatcat ttaggaaatc aaaatcacca tttgcagttt gcaagcatat tttggaaact      180

agtaaagtgg actatgtcct ctttcaagct gccacagcca taatggaagc agttgtccga      240

gagtggattc tcttggaaaa aggtagcatc gagtctctgc gaacattcct tttaacctat      300

gtcttacaaa ggcccaacct tcaaaagtat gttcgggaac agattctact agcagtagca      360

gtaattgtaa aaagaggatc attagataaa tcaattgact gcaaaagcat ttttcatgaa      420

gtcagccagt tgattagtag tggcaatccc actgtgcaaa ctctggcctg ttctattctg      480

actgcgctat tgagtgaatt ttcaagttca agtaaaacta gcaacattgg attgagcatg      540

gaattccatg gtaactgcaa aagagttttt caggaagaag accttcgtca gatcttcatg      600

ttaactgttg aagttctgca ggagttcagc aggcgggaaa acctcaatgc tcagatgtct      660

tcagtatttc agcgttacct tgcactcgcc aatcaagtct tgagctggaa ctttcttcct      720

ccaaatttgg gcagacatta tatagctatg tttgaatcct cgcaaaatgt gctgttgaag      780

ccaacagagt cctggcggga gactcttctg gacagcagag ttatggagct tttcttcaca      840

gtacatcgaa aaatcagaga agattcagat atggcacaag attctctgca gtgccttgcc      900

cagttagctt ctcttcatgg acccatcttc ccagatgaag gatcacaagt tgattatcta      960

gcacacttca ttgagggatt actgaatact atcaatggaa ttgaaataga agattctgaa     1020

gctgtgggga tctccagcat tatcagcaac ctgataaccg tgttcccacg aaatgtttta     1080

actgccattc caagtgaact tttctcctcc tttgttaact gcctcacaca cctcacttgt     1140

tcttttgggc gaagtgctgc attggaagaa gtgcttgata aagatgacat ggtatacatg     1200

gaagcatatg ataaattgtt ggagtcctgg ttaactttgg ttcaagatga caaacatttc     1260

cataaaggct tttttaccca acatgcagtt caagttttca attcctatat tcagtgccac     1320

ctagctgctc cagatggcac aagaaatttg actgccaatg gtgtggcctc tcgtgaggag     1380

gaagaaataa gtgaacttca agaggatgat cgagaccagt tttctgatca actggccagt     1440

gtaggaatgc taggaagaat tgctgcagaa cactgtatac ctcttctgac aagtttatta     1500

gaagaaagag taacaagact ccatggtcag ttacaacgac atcagcaaca gttacttgct     1560

tcaccgggtt caagcactgt tgacaacaaa atgcttgatg atctctatga agatattcac     1620

tggcttattt tagttacagg ctacctctta gctgatgata ctcagggaga gactccgcta     1680

atacctccag aaataatgga atattccatt aagcattcat ctgaagttga cattaataca     1740

acacttcaaa ttttgggatc tccaggagaa aaggcttctt ccatcccagg gtacaacaga     1800

acagattctg tgattaggct gttgtctgcc attctcagag tttcagaagt tgaatctcga     1860

gcaataagag cagatctcac tcatctacta agtccccaga tgggcaaaga tattgtttgg     1920

tttttaaaac gctgggcaaa gacttatctc ctggtggatg aaaaactgta tgatcagata     1980

agtctgccat tcagtacagc gttcggagca gatacagagg gttctcagtg gataattggc     2040

tacctcttac aaaaagtcat cagtaacctc tcagtctgga gtagtgagca ggaccttgca     2100

aatgacactg tgcagctcct tgtcactttg gtggaaagaa gagaaagggc aaacttagta     2160

attcaatgtg agaactggtg gaatttagct aagcagtttg caagccgaag cccacctctt     2220

aatttcttgt caagtcctgt gcagaggaca ttgatgaagg ctctagtctt aggaggtttt     2280

gcacatatgg acacagaaac caaacagcag tattggacag aggttcttca gccacttcag     2340

cagcgattct taagagtgat aaaccaagaa aacttccagc agatgtgtca gcaagaggaa     2400

gtcaagcagg aaatcactgc cacactagag gccctgtgtg gcattgctga ggctacccag     2460

attgacaacg tagcaatcct gtttaatttt ttaatggact tccttaccaa ttgcattgga     2520

ttgatggaag tttacaagaa taccccagag actgtcaatc tcattataga agtttttgtt     2580

gaagttgcac ataaacagat atgctatctt ggagagtcca aagctatgaa cttatatgaa     2640

gcctgcctta ctttgttgca agtgtattct aagaataatt tagggcggca aagaatagat     2700

gttacagcag aagaagagca ataccaagac ctgcttctca ttatggaact tcttactaac     2760

ctgctgtcaa aagaattcat agatttcagt gatacagatg aagtgtttag aggacatgag     2820

ccaggtcaag cagcaaacag atctgtgtca gcagcggatg ttgtgttgta tggagtaaac     2880

ctaattctgc ccttgatgtc acaggatctc ttgaagtttc caaccctttg taatcagtac     2940

tacaaattaa tcacatttat ctgtgagatt tttcctgaaa aaataccaca gcttcctgag     3000

gatctgttta aaagtctgat gtactcccta gaattaggaa tgacatcaat gagttcggag     3060

gtttgccagc tttgcctgga ggccttgaca ccgttagctg aacagtgtgc aaaagcacaa     3120

gaaacagact caccactttt tctagcaaca cggcactttc ttaagctggt ttttgatatg     3180

ctggttttgc aaaagcacaa cacagagatg accactgcgg ctggcgaagc tttctacacg     3240

ttggtgtgtt tgcaccaggc tgaatattct gaactggtcg aaacattact atcaagtcag     3300

caagacccag ttatttacca gagattagca gatgccttca acaagctcac tgcaagcagc     3360

actcctccta cgctggatcg gaagcagaag atggccttct taaagagttt agaagaattt     3420

atggcaaatg ttggtggtct cctttgtgta aaataa                               3456


<210>  1420
<211>  684
<212>  DNA
<213>  homo sapiens

<400>  1420
atgttcaaga gaatggccga atttgggcct gactccggcg ggagagtaaa gggtgttact       60

atcgttaaac caatagttta cggtaatgtt gctcggtatt ttggaaagaa aagagaagaa      120

gatgggcaca ctcatcagtg gacagtatat gtgaaaccat atagaaatga ggatatgtca      180

gcatatgtga agaaaatcca gtttaaatta catgaaagct atggcaatcc tttaagagtt      240

gttactaaac ctccatatga aattactgaa acaggatggg gtgaattcga aataatcatc      300

aaaatatttt tcattgaccc taatgaaaga cctgtaaccc tgtatcattt gctaaagctg      360

tttcaatcag acaccaatgc aatgctgggg aaaaagacag tggtttcaga gttctatgat      420

gaaatgatat ttcaagaccc aacagcaatg atgcaacaat tattgacaac atctcgtcag      480

ctaacattag gagcctataa gcatgaaaca gaatttgcag agcttgaagt gaaaaccaga      540

gaaaaattag aagctgctaa gaaaaaaaca agctttgaga ttgcagagct taaggagaga      600

ttaaaagcaa gtcgtgaaac tataaattgt ttaaaaaatg aaatcagaaa acttgaagaa      660

gatgaccaag caaaagacat ataa                                             684


<210>  1421
<211>  4293
<212>  DNA
<213>  homo sapiens

<400>  1421
atgtccaggc cgagcagcgt ctccccgcgg cagccggctc ctggcggtgg cggaggcggc       60

ggcccctcgc cttgtggccc tgggggcggc ggccgggcca aggggctgaa ggacattcgc      120

attgatgagg aggtgaagat cgcagtcaat atcgcgctgg agcgcttccg atacggggac      180

cagagagaaa tggaatttcc ttcttctttg accagtactg aaagagcctt tattcatcga      240

ctcagtcagt ctcttggttt ggtctctaaa agtaaaggaa agggagcaaa tagataccta      300

actgtgaaga agaaagatgg atcagaaaca gctcatgcaa tgatgacctg taatttgact      360

cataatacaa aacatgctgt taggagccta attcaaagat ttcctgtcac caataaagag      420

cgtacagaac ttctgcctaa aacagaaaga ggaaatgtgt ttgcagttga agctgaaaac      480

cgggaaatga gcaagacaag tgggcgactc aacaatggca tacctcagat tccagtgaaa      540

agaggagaat ccgaatttga ttcttttagg cagtctttac cagtgtttga gaaacaggaa      600

gaaattgtta aaataattaa ggaaaataaa gtagttttga ttgtaggaga aactgggtct      660

ggaaagacca cacagattcc tcagttcctt ttagatgatt gctttaaaaa tggtatcccc      720

tgccgtatat tttgtactca accaagacga ttggcagcta tcgctgtggc tgaaagagtt      780

gccgcagaga gacgggaaag gattggtcaa acaattggtt atcagatccg attagaaagc      840

agggtttctc caaagacact tctgacattt tgtactaatg gggtattgct tcgtacattg      900

atggcaggag atagtacgtt gtcgactgtg acacatgtta tcgtggatga agtgcatgaa      960

agggatcgat ttagtgattt tttacttaca aagttaagag atttgttgca aaagcaccca     1020

actttgaaac taattctttc tagtgctgcc ttggatgtaa atctctttat aagatatttt     1080

ggaagttgtc cagtgatata tatacaggga agaccatttg aagtaaaaga aatgtttctg     1140

gaagatattt taagaacaac tggatataca aacaaagaaa tgttaaaata taaaaaggaa     1200

aaacagcaag aagagaaaca acaaaccaca cttacagaat ggtactcagc tcaagaaaat     1260

agtttcaagc ctgaatctca gaggcagaga actgttctaa atgtgactga tgagtatgac     1320

ttactggatg atggtggtga tgctgtcttc agtcagctga ctgaaaaaga tgtgaattgc     1380

cttgaaccat ggttaataaa ggaaatggat gcttgccttt ctgatatatg gctacataaa     1440

gatattgatg cctttgctca ggtctttcat ctcattttaa ctgaaaatgt tagtgttgat     1500

tacagacata gtgaaaccag tgcaacagct ctgatggttg ctgcaggacg tggctttgca     1560

agtcaagtag aacagttaat cagtatggga gccaatgtcc atagtaaagc atcaaatggc     1620

tggatggcat tggattgggc taaacacttt gggcagactg aaattgtgga tcttctagaa     1680

tcttacagtg ctacactgga atttggaaat ctagatgaaa gttctctggt tcaaacaaat     1740

ggaagtgacc tcagtgctga agacagagag ctcctgaaag cttatcatca tagtttcgat     1800

gatgaaaaag tagacttgga tttgatcatg catcttctat acaatatctg ccatagttgt     1860

gatgctggtg cagtactaat ttttctgcct ggatatgacg aaattgttgg actgagagat     1920

cgcatcctgt ttgatgacaa gcggtttgct gacagtacac atagatacca agtctttatg     1980

cttcattcaa atatgcaaac atccgatcaa aagaaagtat taaaaaaccc acctgcaggt     2040

gttcgaaaaa taattctttc caccaatatt gctgaaacca gcatcacagt caatgatgtt     2100

gtctttgtta ttgattctgg taaggtgaaa gagaaatcct ttgatgctct gaattttgtt     2160

acaatgttaa aaatggtatg gatttccaaa gctagtgcca tacagcggaa aggcagggca     2220

gggcgatgta gacctggaat ttgttttcgt ctgttcagta gactccgatt ccagaatatg     2280

ttggaatttc agactccgga acttttgaga atgccattac aggaactttg cttacatacc     2340

aagctgttag ccccagttaa ttgtcccatt gctgattttc ttatgaaagc tcctgaacct     2400

ccaccagctt taattgtaag aaatgctgta caaatgctta agacaataga tgcaatggat     2460

acatgggaag atctgactga acttgggtat catttggctg acttgccagt agaaccacat     2520

cttggtaaaa tggtcttgtg tgctgttgtt ttaaagtgtc tggaccccat ccttacaatt     2580

gcttgcacac tagcttatcg agatcctttt gtactaccta ctcaggcctc tcaaaaacgt     2640

gcagctatgc tttgtaggaa acgttttact gcaggagctt tcagtgacca tatggcactt     2700

ctcagagcat tccaggcctg gcaaaaagca cgaagtgatg ggtgggagcg agccttttgt     2760

gaaaagaatt ttctttcaca ggctactatg gaaataatca taggcatgag aacacagttg     2820

cttggtcaac ttagagcatc aggttttgtt agagcacgag gtggtggtga cattcgggac     2880

gttaacacaa actctgagaa ttgggctgtc gttaaagctg cattggtggc aggcatgtat     2940

cctaatttag tccacgtgga cagagagaat ctagtgttga cagggccaaa ggagaaaaaa     3000

gtacgatttc atcctgcttc agttctcagt cagcctcaat ataaaaagat tcctccagcc     3060

aatggtcaag ctgcagcaat taaggcactg cccacagatt ggcttattta tgatgaaatg     3120

accagagccc atagaatagc taatattaga tgttgttcag cagtgacgcc tgtcactata     3180

ttggtattct gtggaccagc tagattggca agtaatgctc ttcaggaacc ttcatccttt     3240

agagtggatg gcattcccaa tgacagtagt gatagtgaaa tggaggacaa aactacagct     3300

aatttggcag ccttgaaact tgatgagtgg ctccatttca cactggagcc agaggcagct     3360

agtttattgc tgcagctcag acagaagtgg catagcttat ttttacgccg aatgagagct     3420

ccatctaaac cttggtctca agttgatgaa gctaccataa gagcaattat agctgtttta     3480

agcactgaag aacagtctgc aggtttacaa caaccatctg ggattggcca aaggccaagg     3540

cctatgtctt cagaagagct tcctttggcc tcatcttgga ggtcaaataa tagtaggaaa     3600

agttcagcag atactgaatt ttctgatgag tgtactactg cagaaagagt actgatgaaa     3660

tctccatctc cagcattaca cccacctcag aagtacaaag atagaggaat tttacatcct     3720

aaacgaggta ctgaggaccg atcagatcag tcttctctga aatctacaga cagcagtagt     3780

tacccaagtc cttgtgctag tccttctcct ccatcctcag gaaagggctc aaaatctcct     3840

tcgccaagac caaacatgcc tgttcgatac ttcataatga agagtagcaa tttgagaaac     3900

cttgaaattt ctcaacagaa gggtatctgg tctacaactc ctagtaatga acggaagcta     3960

aatcgagcct tttgggaaag cagcatagtt tacttggtat tttctgttca aggatctgga     4020

catttccagg gattttctag gatgtcttct gagattggaa gggaaaagag tcaggactgg     4080

ggctctgctg gactaggagg agtatttaag gtggagtgga tacgaaaaga aagccttccc     4140

tttcaatttg cacaccattt actcaatcca tggaatgaca acaagaaagt gcagataagc     4200

agggatgggc aggaactaga acctctggtt ggtgaacagt tgctccagtt atgggaacgt     4260

cttcccttgg gagaaaaaaa cacaactgat tga                                  4293


<210>  1422
<211>  1809
<212>  DNA
<213>  homo sapiens

<400>  1422
atggcacgtt taacaaaaag acgacaggcg gatacaaaag ctatccagca tctttgggca       60

gccattgaga ttatacggaa ccagaagcag attgccaaca ttgaccgtat tacaaagtat      120

atgtctcgag tccacggtat gcaccctaaa gagaccaccc gtcagctgag cttagctgtg      180

aaagatggtc ttattgtcga aactctaaca gtgggctgca aaggttcaaa agctggtatt      240

gaacaagaag gatattggtt gccaggagat gagattgact gggaaacaga aaatcatgac      300

tggtattgtt ttgaatgcca tttgcctgga gaggtgttga tatgtgacct gtgttttcgt      360

gtgtatcatt ccaagtgttt gtctgatgag ttcaggctta gagacagcag tagtccctgg      420

cagtgcccag tttgcaggag cattaagaag aagaatacaa acaaacagga gatgggcaca      480

tacctcagat tcattgtctc ccgcatgaag gagagggcta tagatcttaa taaaaagggg      540

aaggacaata aacacccgat gtacaggagg ctggtgcact cagctgtgga cgttcccacc      600

attcaagaga aagtgaatga agggaaatac cgaagttatg aagagttcaa agctgatgcc      660

caattgcttc tccacaatac cgtgattttc tatggagcag acagtgagca agctgacatt      720

gcgaggatgc tatataaaga cacatgtcat gagctggatg aactgcagct ttgcaagaat      780

tgcttttact tgtcaaatgc tcgtcctgac aactggttct gttatccttg tatacctaat      840

catgagctgg tttgggctaa aatgaaaggt tttgggtttt ggccagccaa agtcatgcag      900

aaagaagaca atcaagtcga cgttcgcttc tttggccacc accaccagag ggcctggatt      960

ccttctgaaa acattcaaga tatcacagtc aacattcatc ggctgcacgt gaagcgcagt     1020

atgggttgga aaaaggcctg tgatgagctg gagctgcatc agcgtttcct acgagaaggg     1080

agattttgga aatctaagaa tgaggaccga ggtgaggaag aggcagaatc cagtatctcc     1140

tccaccagta atgagcagct aaaggtcact caagaaccaa gagcaaagaa aggacgacgt     1200

aatcaaagtg tggagcccaa aaaggaagaa ccagagcctg aaacagaagc agtaagttct     1260

agccaggaaa tacccacgat gcctcagccc atcgaaaaag tctccgtgtc aactcagaca     1320

aagaagttaa gtgcctcttc accaagaatg ctgcatcgga gcacccagac cacaaacgac     1380

ggcgtgtgtc agagcatgtg ccatgacaaa tacaccaaga tcttcaatga cttcaaagac     1440

cggatgaagt cggaccacaa gcgggagaca gagcgtgttg tccgagaagc tctggagaag     1500

ctgcgttctg aaatggaaga agaaaagaga caagctgtaa ataaagctgt agccaacatg     1560

cagggtgaga tggacagaaa atgtaagcaa gtaaaggaaa agtgtaagga agaatttgta     1620

gaagaaatca agaagctggc aacacagcac aagcaactga tttctcagac caagaagaag     1680

cagtggtgct acaactgtga ggaggaggcc atgtaccact gctgctggaa cacatcctac     1740

tgctccatca agtgccagca ggagcactgg cacgcggagc acaagcgcac ctgccgccgg     1800

aaaagatga                                                             1809


<210>  1423
<211>  2862
<212>  DNA
<213>  homo sapiens

<400>  1423
atggaagaaa gtagcagtgt tgccatgttg gtgccagata ttggggaaca ggaagctata       60

ctgactgctg aaagtatcat cagtccttca ttggaaattg atgaacaaag aaaaactaaa      120

ccagatccat taatccatgt tatccagaag ttaagcaaga tagtggaaaa tgaaaagtca      180

caaaaatgtc ttttaattgg gaagaaacgc ccacgttcaa gtgctgcaac acactctctt      240

gaaacccaag aactttgtga gattccggct aaagtaatcc agtcacctgc tgctgatact      300

agaagggctg agatgtcaca aacaaatttt acccctgaca ctcttgccca gaatgaaggg      360

aaggctatgt cttatcagtg tagcctttgt aagtttctat catcatcctt ttccgtgtta      420

aaagatcata ttaagcaaca tggtcagcaa aatgaagtga tactgatgtg ctcagagtgc      480

catattacat ctagaagcca ggaggaactt gaagcccacg tggtgaatga ccatgacaat      540

gatgccaata tccacaccca atccaaagcc caacagtgcg taagcccctc cagctctttg      600

tgtcggaaaa ccacagaaag aaatgaaacc attccagata tcccagtaag tgtggacaat      660

ctacagactc atactgtcca aactgcatct gtggcagaaa tgggtaggag gaaatggtat      720

gcatacgaac agtacggcat gtatcgatgc ttgttttgta gttatacttg tggccagcag      780

agaatgttga aaacacacgc ttggaaacat gctggggagg ttgattgctc ctatccaatc      840

tttgaaaatg aaaatgaacc cctaggcctg ctggattctt cagcagctgc tgcgcctggt      900

ggggtcgatg cagtcgtcat tgctattgga gagagtgaac tgagtatcca caatgggcca      960

tcagtgcaag tgcagatttg cagctcagaa cagttatcat cttcatctcc tttagaacag     1020

agtgcagaaa gaggagtaca cctaagtcag tcagttaccc tggaccccaa tgaggaagaa     1080

atgctagaag tgatttctga tgcagaggag aatctgattc ctgatagcct gcttacatca     1140

gcacagaaaa tcatcagcag cagccccaat aaaaaagggc atgttaacgt gatagtggag     1200

cgattgccaa gtgctgaaga aaccctttca cagaagcgct tcctcatgaa cactgaaatg     1260

gaagaaggga aggacctgag cctgacagaa gctcagattg ggcgcgaagg aatggatgat     1320

gtttatcgtg ctgataaatg tactgttgat attgggggat tgatcatagg ctggagcagt     1380

tcagagaaaa aagacgagtt aatgaataaa ggcctggcta ctgatgagaa tgccccacca     1440

ggccggagaa ggacaaattc tgagtctctt cgattacact cattagctgc agaagccctt     1500

gtcacaatgc ctataagagc tgcagagttg acaagagcca acctggggca ctatggagat     1560

ataaaccttt tagatccaga tactagtcaa aggcaagtag atagtacatt ggcagcgtac     1620

tcaaaaatga tgtcgccact taaaaactct tcagatggat taactagtct taaccaaagc     1680

aactccacct tggtagcact cccagagggt aggcaggaat tgtcagatgg gcaggttaag     1740

acaggcatca gcatgtcctt actcaccgtc attgaaaaat tgagagaaag gacagaccaa     1800

aacgcttcag acgatgacat tttgaaagag ttgcaggaca acgcccagtg ccaacccaac     1860

agcgatacaa gtttgtccgg aaacaatgtg gtggaataca tcccgaatgc tgaacgaccc     1920

taccgttgcc gcctgtgtca ctacacaagt ggcaacaagg gctacatcaa gcagcactta     1980

cgagtccatc gacagagaca gccttatcag tgtcctatct gcgagcacat agcggacaac     2040

agcaaagatt tggagagtca catgatccac cactgtaaga caagaatata ccagtgcaag     2100

cagtgtgaag aatccttcca ttataagagt caattgagga accatgagag agaacagcac     2160

agtcttccag ataccttgtc aatagcaact tctaatgagc caagaatttc cagtgataca     2220

gctgatggaa aatgtgtcca ggaagggaat aagtcttcag tccagaaaca atatagatgt     2280

gatgtgtgtg attatacaag tacaacatat gttggtgtca gaaaccacag gcgaatccat     2340

aactctgata agccgtacag atgctctctg tgtgggtatg tgtgtagcca tcctccttct     2400

ttgaagtctc atatgtggaa acatgcaagt gaccaaaatt acaactacga acaagtaaac     2460

aaggctatta acgacgcgat ttcacaaagt ggcagagttc tggggaaatc ccctggaaag     2520

actcaattaa agagcagtga agagagtgca gatcccgtca ctggaagttc agaaaatgca     2580

gtgtcatctt cagaactgat gtcccagact cccagtgaag ttctgggtac caacgagaat     2640

gagaaactga gccctacaag taatacctca tatagtttag aaaaaatctc cagtctggcc     2700

cctcctagca tggagtactg cgttttactc ttctgctgtt gtatttgtgg ttttgaatca     2760

accagcaaag aaaacctctt ggatcatatg aaagagcacg agggtgaaat tgtaaacatc     2820

atcctgaata aggaccacaa tacagctcta aacacaaatt ag                        2862


<210>  1424
<211>  1065
<212>  DNA
<213>  homo sapiens

<400>  1424
atgtcagcct ttgatatgtc ccatgatttc tttttctgct taacttcaga atgggaaata       60

caacctagaa ccaaacggtc atcacttcag cagggttttt tgaagaatca aatattcact      120

gggatacaaa tgcagacaag aagctacagt ggatggaaac tctgtgagaa ttgtggagag      180

gtcttcagtg aacagttttg ccttaagaca cacatgagag ctcagaatgg agggaacact      240

tttgagggta attgttatgg aaaagacagc atcagtgtgc acaaggaagc ctctattgga      300

caagaacttt ccaaatttaa tccatgtgga aaagtcttca ccttaactcc aggccttgct      360

gtgcatcttg aaattctcaa tggaagacaa ccctacaaat gtaaggaatg tggaaaaggc      420

tttaagtatt ttgcaagcct tgataatcac atgggaatcc acattggaga gaaactctgt      480

gaatttcagg aatgtgagag agccatcaca acttcctcac acttaaagca gtgtgtagca      540

gttcatactg gaaagaaatc cgaaaagact aagaactgtg ggaaatcctt cactaatttt      600

tctcaacttt ctgcacatgc aaaaactcat aaaggagaga agtcctttga atgtaaagaa      660

tgtggaagat cctttagaaa ttcctcatcc tttaatgttc acattcaaat tcacactgga      720

ataaaaccac acaaatgtac ggaatgtggg aaagccttca ctagatcaac tcaccttact      780

caacatgtaa gaactcacac tggaataaaa ccctatgaat gtaaggaatg tggccaagcc      840

ttcactcagt acacgggcct tgctatacac atacgaaatc acactggaga gaaaccctat      900

cagtgtaagg aatgtgggaa agccttcaat agatcttcaa cgcttactca acatagaaga      960

attcacacag gagagaagcc ttatgaatgt gttgaatgtg ggaagacctt cattacttct     1020

tcccatcgta gtaaacattt gaaaactcac agtggagaaa ggtaa                     1065


<210>  1425
<211>  918
<212>  PRT
<213>  homo sapiens

<400>  1425

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  1426
<211>  688
<212>  PRT
<213>  homo sapiens

<400>  1426

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Arg Ile 
            20                  25                  30          


Val Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Ala 
        35                  40                  45              


Glu Arg Asn Glu Ile Thr Phe Asp Lys Ile Phe Asn Gln Lys Ile Gly 
    50                  55                  60                  


Phe Leu Leu Phe Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val 
65                  70                  75                  80  


Pro Gln Val Lys Phe Tyr Glu Glu Ile Lys Glu Tyr Glu Lys Leu Asp 
                85                  90                  95      


Asn Glu Glu Asp Arg Leu Cys Arg Ser Arg Gln Ile Tyr Asp Ala Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ser Cys Ser His Pro Phe Ser Lys Gln Ala 
        115                 120                 125             


Val Glu His Val Gln Ser His Leu Ser Lys Lys Gln Val Thr Ser Thr 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Glu Ser Leu Arg Gly Asp 
145                 150                 155                 160 


Ile Phe Gln Lys Phe Met Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Glu Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Thr Tyr Ala Phe His Thr Pro Asp Lys Leu Cys Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Lys Glu Met Arg Phe Tyr Ala Thr Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Ala Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Thr Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Val Asn Val Glu Leu Pro Asp Thr 
                405                 410                 415     


Phe Ser Pro Glu Leu Lys Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Ser Lys Arg Leu Gly Cys His Gly Gly Gly Ser Gln Glu Val Lys 
        435                 440                 445             


Glu His Ser Phe Phe Lys Gly Val Asp Trp Gln His Val Tyr Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Cys Asp Gln Glu Leu Tyr Lys Asn Phe Pro Leu Val 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Thr Glu Thr Val Tyr Glu Ala 
        515                 520                 525             


Val Asn Ala Asp Thr Asp Lys Ile Glu Ala Arg Lys Arg Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Leu Lys Leu Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ser Arg Gln Asn Leu Leu Thr Met Glu Gln Ile Leu Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Asp Lys Lys Cys Ile Leu Phe Arg Ile 
    610                 615                 620                 


Lys Gly Gly Lys Gln Phe Val Leu Gln Cys Glu Ser Asp Pro Glu Phe 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Asn Glu Thr Phe Lys Glu Ala Gln Arg 
                645                 650                 655     


Leu Leu Arg Arg Ala Pro Lys Phe Leu Asn Lys Pro Arg Ser Gly Thr 
            660                 665                 670         


Val Glu Leu Pro Lys Pro Ser Leu Cys His Arg Asn Ser Asn Gly Leu 
        675                 680                 685             


<210>  1427
<211>  484
<212>  PRT
<213>  homo sapiens

<400>  1427

Met Ala Ala Gly Gly Asp His Gly Ser Pro Asp Ser Tyr Arg Ser Pro 
1               5                   10                  15      


Leu Ala Ser Arg Tyr Ala Ser Pro Glu Met Cys Phe Val Phe Ser Asp 
            20                  25                  30          


Arg Tyr Lys Phe Arg Thr Trp Arg Gln Leu Trp Leu Trp Leu Ala Glu 
        35                  40                  45              


Ala Glu Gln Thr Leu Gly Leu Pro Ile Thr Asp Glu Gln Ile Gln Glu 
    50                  55                  60                  


Met Lys Ser Asn Leu Glu Asn Ile Asp Phe Lys Met Ala Ala Glu Glu 
65                  70                  75                  80  


Glu Lys Arg Leu Arg His Asp Val Met Ala His Val His Thr Phe Gly 
                85                  90                  95      


His Cys Cys Pro Lys Ala Ala Gly Ile Ile His Leu Gly Ala Thr Ser 
            100                 105                 110         


Cys Tyr Val Gly Asp Asn Thr Asp Leu Ile Ile Leu Arg Asn Ala Leu 
        115                 120                 125             


Asp Leu Leu Leu Pro Lys Leu Ala Arg Val Ile Ser Arg Leu Ala Asp 
    130                 135                 140                 


Phe Ala Lys Glu Arg Ala Ser Leu Pro Thr Leu Gly Phe Thr His Phe 
145                 150                 155                 160 


Gln Pro Ala Gln Leu Thr Thr Val Gly Lys Arg Cys Cys Leu Trp Ile 
                165                 170                 175     


Gln Asp Leu Cys Met Asp Leu Gln Asn Leu Lys Arg Val Arg Asp Asp 
            180                 185                 190         


Leu Arg Phe Arg Gly Val Lys Gly Thr Thr Gly Thr Gln Ala Ser Phe 
        195                 200                 205             


Leu Gln Leu Phe Glu Gly Asp Asp His Lys Val Glu Gln Leu Asp Lys 
    210                 215                 220                 


Met Val Thr Glu Lys Ala Gly Phe Lys Arg Ala Phe Ile Ile Thr Gly 
225                 230                 235                 240 


Gln Thr Tyr Thr Arg Lys Val Asp Ile Glu Val Leu Ser Val Leu Ala 
                245                 250                 255     


Ser Leu Gly Ala Ser Val His Lys Ile Cys Thr Asp Ile Arg Leu Leu 
            260                 265                 270         


Ala Asn Leu Lys Glu Met Glu Glu Pro Phe Glu Lys Gln Gln Ile Gly 
        275                 280                 285             


Ser Ser Ala Met Pro Tyr Lys Arg Asn Pro Met Arg Ser Glu Arg Cys 
    290                 295                 300                 


Cys Ser Leu Ala Arg His Leu Met Thr Leu Val Met Asp Pro Leu Gln 
305                 310                 315                 320 


Thr Ala Ser Val Gln Trp Phe Glu Arg Thr Leu Asp Asp Ser Ala Asn 
                325                 330                 335     


Arg Arg Ile Cys Leu Ala Glu Ala Phe Leu Thr Ala Asp Thr Ile Leu 
            340                 345                 350         


Asn Thr Leu Gln Asn Ile Ser Glu Gly Leu Val Val Tyr Pro Lys Val 
        355                 360                 365             


Ile Glu Arg Arg Ile Arg Gln Glu Leu Pro Phe Met Ala Thr Glu Asn 
    370                 375                 380                 


Ile Ile Met Ala Met Val Lys Ala Gly Gly Ser Arg Gln Asp Cys His 
385                 390                 395                 400 


Glu Lys Ile Arg Val Leu Ser Gln Gln Ala Ala Ser Val Val Lys Gln 
                405                 410                 415     


Glu Gly Gly Asp Asn Asp Leu Ile Glu Arg Ile Gln Val Asp Ala Tyr 
            420                 425                 430         


Phe Ser Pro Ile His Ser Gln Leu Asp His Leu Leu Asp Pro Ser Ser 
        435                 440                 445             


Phe Thr Gly Arg Ala Ser Gln Gln Val Gln Arg Phe Leu Glu Glu Glu 
    450                 455                 460                 


Val Tyr Pro Leu Leu Lys Pro Tyr Glu Ser Val Met Lys Val Lys Ala 
465                 470                 475                 480 


Glu Leu Cys Leu 
                


<210>  1428
<211>  346
<212>  PRT
<213>  homo sapiens

<400>  1428

Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  1429
<211>  364
<212>  PRT
<213>  homo sapiens

<400>  1429

Met Leu Leu Ser Leu Val Leu His Thr Tyr Ser Met Arg Tyr Leu Leu 
1               5                   10                  15      


Pro Ser Val Val Leu Leu Gly Thr Ala Pro Thr Tyr Val Leu Ala Trp 
            20                  25                  30          


Gly Val Trp Arg Leu Leu Ser Ala Phe Leu Pro Ala Arg Phe Tyr Gln 
        35                  40                  45              


Ala Leu Asp Asp Arg Leu Tyr Cys Val Tyr Gln Ser Met Val Leu Phe 
    50                  55                  60                  


Phe Phe Glu Asn Tyr Thr Gly Val Gln Ile Leu Leu Tyr Gly Asp Leu 
65                  70                  75                  80  


Pro Lys Asn Lys Glu Asn Ile Ile Tyr Leu Ala Asn His Gln Ser Thr 
                85                  90                  95      


Val Asp Trp Ile Val Ala Asp Ile Leu Ala Ile Arg Gln Asn Ala Leu 
            100                 105                 110         


Gly His Val Arg Tyr Val Leu Lys Glu Gly Leu Lys Trp Leu Pro Leu 
        115                 120                 125             


Tyr Gly Cys Tyr Phe Ala Gln His Gly Gly Ile Tyr Val Lys Arg Ser 
    130                 135                 140                 


Ala Lys Phe Asn Glu Lys Glu Met Arg Asn Lys Leu Gln Ser Tyr Val 
145                 150                 155                 160 


Asp Ala Gly Thr Pro Met Tyr Leu Val Ile Phe Pro Glu Gly Thr Arg 
                165                 170                 175     


Tyr Asn Pro Glu Gln Thr Lys Val Leu Ser Ala Ser Gln Ala Phe Ala 
            180                 185                 190         


Ala Gln Arg Gly Leu Ala Val Leu Lys His Val Leu Thr Pro Arg Ile 
        195                 200                 205             


Lys Ala Thr His Val Ala Phe Asp Cys Met Lys Asn Tyr Leu Asp Ala 
    210                 215                 220                 


Ile Tyr Asp Val Thr Val Val Tyr Glu Gly Lys Asp Asp Gly Gly Gln 
225                 230                 235                 240 


Arg Arg Glu Ser Pro Thr Met Thr Glu Phe Leu Cys Lys Glu Cys Pro 
                245                 250                 255     


Lys Ile His Ile His Ile Asp Arg Ile Asp Lys Lys Asp Val Pro Glu 
            260                 265                 270         


Glu Gln Glu His Met Arg Arg Trp Leu His Glu Arg Phe Glu Ile Lys 
        275                 280                 285             


Asp Lys Met Leu Ile Glu Phe Tyr Glu Ser Pro Asp Pro Glu Arg Arg 
    290                 295                 300                 


Lys Arg Phe Pro Gly Lys Ser Val Asn Ser Lys Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Thr Leu Pro Ser Met Leu Ile Leu Ser Gly Leu Thr Ala Gly Met Leu 
                325                 330                 335     


Met Thr Asp Ala Gly Arg Lys Leu Tyr Val Asn Thr Trp Ile Tyr Gly 
            340                 345                 350         


Thr Leu Leu Gly Cys Leu Trp Val Thr Ile Lys Ala 
        355                 360                 


<210>  1430
<211>  1001
<212>  PRT
<213>  homo sapiens

<400>  1430

Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys 
1               5                   10                  15      


Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
            20                  25                  30          


Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
        35                  40                  45              


Arg Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr 
    50                  55                  60                  


Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
65                  70                  75                  80  


Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                85                  90                  95      


Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Ser Ser 
            100                 105                 110         


Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
        115                 120                 125             


Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
    130                 135                 140                 


Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys 
145                 150                 155                 160 


Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                165                 170                 175     


Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
            180                 185                 190         


Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
        195                 200                 205             


Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu 
    210                 215                 220                 


His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly 
225                 230                 235                 240 


Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                245                 250                 255     


Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
            260                 265                 270         


Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
        275                 280                 285             


Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
    290                 295                 300                 


Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
305                 310                 315                 320 


Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile 
                325                 330                 335     


Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met 
            340                 345                 350         


Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
        355                 360                 365             


Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly 
    370                 375                 380                 


Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu 
385                 390                 395                 400 


Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg 
                405                 410                 415     


Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala 
            420                 425                 430         


Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
        435                 440                 445             


Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
    450                 455                 460                 


Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu 
465                 470                 475                 480 


Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                485                 490                 495     


Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys 
            500                 505                 510         


Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
        515                 520                 525             


Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly 
    530                 535                 540                 


Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln 
545                 550                 555                 560 


Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile 
                565                 570                 575     


Glu Lys Thr Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
            580                 585                 590         


Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
        595                 600                 605             


Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
    610                 615                 620                 


Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
625                 630                 635                 640 


Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                645                 650                 655     


Met Leu Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr 
            660                 665                 670         


Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val 
        675                 680                 685             


Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr 
    690                 695                 700                 


Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
705                 710                 715                 720 


Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr 
                725                 730                 735     


Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
            740                 745                 750         


Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu 
        755                 760                 765             


Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
    770                 775                 780                 


Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
785                 790                 795                 800 


Val Pro Leu Thr Glu Met Pro Glu Ala Val Asp Val Asp Glu Ser Gln 
                805                 810                 815     


Leu Glu Asn Val Cys Leu Ser Trp Gln Asn Glu Thr Ser Ser Gly Asn 
            820                 825                 830         


Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Thr Gly Gly Leu Leu Asp 
        835                 840                 845             


Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr Ser Tyr 
    850                 855                 860                 


Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His Thr Glu 
865                 870                 875                 880 


Ile Thr Pro Glu Ala Lys Thr Lys Ser Tyr Phe Pro Glu Ser Gln Asn 
                885                 890                 895     


Asp Val Gly Lys Gln Ser Thr Lys Glu Thr Leu Lys Pro Lys Ile His 
            900                 905                 910         


Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln 
        915                 920                 925             


Lys Ser Leu Glu Glu Thr Ser Lys Leu Ile Ile Glu Glu Thr Lys Pro 
    930                 935                 940                 


Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Thr Ser Pro Ala Asp 
945                 950                 955                 960 


Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser 
                965                 970                 975     


Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Thr Lys Lys Glu Ile 
            980                 985                 990         


Arg His Val Glu Lys Lys Ser His  Ser 
        995                 1000     


<210>  1431
<211>  1501
<212>  PRT
<213>  homo sapiens

<400>  1431

Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Thr Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Thr Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Thr Ser Val Leu Ser Thr Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Thr 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Thr Phe Leu Pro His Arg Ser Thr Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Thr Asp Gln Leu Gly Leu Glu Gln Asp Phe 
    130                 135                 140                 


Glu Gln Lys Gln Met Pro Glu Gly Lys Leu Asn Val Asp Gly Phe Leu 
145                 150                 155                 160 


Leu Cys Ile Asp Val Ser Gln Gly Cys Asn Arg Lys Phe Asp Asp Gln 
                165                 170                 175     


Leu Lys Phe Val Asn Asn Leu Phe Val Gln Leu Ser Lys Ser Lys Lys 
            180                 185                 190         


Pro Val Ile Ile Ala Ala Thr Lys Cys Asp Glu Cys Val Asp His Tyr 
        195                 200                 205             


Leu Arg Glu Val Gln Ala Phe Ala Ser Asn Lys Lys Asn Leu Leu Val 
    210                 215                 220                 


Val Glu Thr Ser Ala Arg Phe Asn Val Asn Ile Glu Thr Cys Phe Thr 
225                 230                 235                 240 


Ala Leu Val Gln Met Leu Asp Lys Thr Arg Ser Lys Pro Lys Ile Ile 
                245                 250                 255     


Pro Tyr Leu Asp Ala Tyr Lys Thr Gln Arg Gln Leu Val Val Thr Ala 
            260                 265                 270         


Thr Asp Lys Phe Glu Lys Leu Val Gln Thr Val Arg Asp Tyr His Ala 
        275                 280                 285             


Thr Trp Lys Thr Val Ser Asn Lys Leu Lys Asn His Pro Asp Tyr Glu 
    290                 295                 300                 


Glu Tyr Ile Asn Leu Glu Gly Thr Arg Lys Ala Arg Asn Thr Phe Ser 
305                 310                 315                 320 


Lys His Ile Glu Gln Leu Lys Gln Glu His Ile Arg Lys Arg Arg Glu 
                325                 330                 335     


Glu Tyr Ile Asn Thr Leu Pro Arg Ala Phe Asn Thr Leu Leu Pro Asn 
            340                 345                 350         


Leu Glu Glu Ile Glu His Leu Asn Trp Ser Glu Ala Leu Lys Leu Met 
        355                 360                 365             


Glu Lys Arg Ala Asp Phe Gln Leu Cys Phe Val Val Leu Glu Lys Thr 
    370                 375                 380                 


Pro Trp Asp Glu Thr Asp His Ile Asp Lys Ile Asn Asp Arg Arg Ile 
385                 390                 395                 400 


Pro Phe Asp Leu Leu Ser Thr Leu Glu Ala Glu Lys Val Tyr Gln Asn 
                405                 410                 415     


His Val Gln His Leu Ile Ser Glu Lys Arg Arg Val Glu Met Lys Glu 
            420                 425                 430         


Lys Phe Lys Lys Thr Leu Glu Lys Ile Gln Phe Ile Ser Pro Gly Gln 
        435                 440                 445             


Pro Trp Glu Glu Val Met Cys Phe Val Met Glu Asp Glu Ala Tyr Lys 
    450                 455                 460                 


Tyr Ile Thr Glu Ala Asp Ser Lys Glu Val Tyr Gly Arg His Gln Arg 
465                 470                 475                 480 


Glu Ile Val Glu Lys Ala Lys Glu Glu Phe Gln Glu Met Leu Phe Glu 
                485                 490                 495     


His Ser Glu Leu Phe Tyr Asp Leu Asp Leu Asn Ala Thr Pro Ser Ser 
            500                 505                 510         


Asp Lys Met Ser Glu Ile His Thr Val Leu Ser Glu Glu Pro Arg Tyr 
        515                 520                 525             


Lys Ala Leu Gln Lys Leu Ala Pro Asp Arg Glu Ser Leu Leu Leu Lys 
    530                 535                 540                 


His Ile Gly Phe Val Tyr His Pro Thr Lys Glu Thr Cys Leu Ser Gly 
545                 550                 555                 560 


Gln Asn Cys Thr Asp Ile Lys Val Glu Gln Leu Leu Ala Ser Ser Leu 
                565                 570                 575     


Leu Gln Leu Asp His Gly Arg Leu Arg Leu Tyr His Asp Ser Thr Asn 
            580                 585                 590         


Ile Asp Lys Val Asn Leu Phe Ile Leu Gly Lys Asp Gly Leu Ala Gln 
        595                 600                 605             


Glu Leu Ala Asn Glu Ile Arg Thr Gln Ser Thr Asp Asp Glu Tyr Ala 
    610                 615                 620                 


Leu Asp Gly Lys Ile Tyr Glu Leu Asp Leu Arg Pro Val Asp Ala Lys 
625                 630                 635                 640 


Ser Pro Tyr Phe Leu Ser Gln Leu Trp Thr Ala Ala Phe Lys Pro His 
                645                 650                 655     


Gly Cys Phe Cys Val Phe Asn Ser Ile Glu Ser Leu Ser Phe Ile Gly 
            660                 665                 670         


Glu Phe Ile Gly Lys Ile Arg Thr Glu Ala Ser Gln Ile Arg Lys Asp 
        675                 680                 685             


Lys Tyr Met Ala Asn Leu Pro Phe Thr Leu Ile Leu Ala Asn Gln Arg 
    690                 695                 700                 


Asp Ser Ile Ser Lys Asn Leu Pro Ile Leu Arg His Gln Gly Gln Gln 
705                 710                 715                 720 


Leu Ala Asn Lys Leu Gln Cys Pro Phe Val Asp Val Pro Ala Gly Thr 
                725                 730                 735     


Tyr Pro Arg Lys Phe Asn Glu Thr Gln Ile Lys Gln Ala Leu Arg Gly 
            740                 745                 750         


Val Leu Glu Ser Val Lys His Asn Leu Asp Val Val Ser Pro Ile Pro 
        755                 760                 765             


Ala Asn Lys Asp Leu Ser Glu Ala Asp Leu Arg Ile Val Met Cys Ala 
    770                 775                 780                 


Met Cys Gly Asp Pro Phe Ser Val Asp Leu Ile Leu Ser Pro Phe Leu 
785                 790                 795                 800 


Asp Ser His Ser Cys Ser Ala Ala Gln Ala Gly Gln Asn Asn Ser Leu 
                805                 810                 815     


Met Leu Asp Lys Ile Ile Gly Glu Lys Arg Arg Arg Ile Gln Ile Thr 
            820                 825                 830         


Ile Leu Ser Tyr His Ser Ser Ile Gly Val Arg Lys Asp Glu Leu Val 
        835                 840                 845             


His Gly Tyr Ile Leu Val Tyr Ser Ala Lys Arg Lys Ala Ser Met Gly 
    850                 855                 860                 


Met Leu Arg Ala Phe Leu Ser Glu Val Gln Asp Thr Ile Pro Val Gln 
865                 870                 875                 880 


Leu Val Ala Val Thr Asp Ser Gln Ala Asp Phe Phe Glu Asn Glu Ala 
                885                 890                 895     


Ile Lys Glu Leu Met Thr Glu Gly Glu His Ile Ala Thr Glu Ile Thr 
            900                 905                 910         


Ala Lys Phe Thr Ala Leu Tyr Ser Leu Ser Gln Tyr His Arg Gln Thr 
        915                 920                 925             


Glu Val Phe Thr Leu Phe Phe Ser Asp Val Leu Glu Lys Lys Asn Met 
    930                 935                 940                 


Ile Glu Asn Ser Tyr Leu Ser Asp Asn Thr Arg Glu Ser Thr His Gln 
945                 950                 955                 960 


Ser Glu Asp Val Phe Leu Pro Ser Pro Arg Asp Cys Phe Pro Tyr Asn 
                965                 970                 975     


Asn Tyr Pro Asp Ser Asp Asp Asp Thr Glu Ala Pro Pro Pro Tyr Ser 
            980                 985                 990         


Pro Ile Gly Asp Asp Val Gln Leu  Leu Pro Thr Pro Ser  Asp Arg Ser 
        995                 1000                 1005             


Arg Tyr  Arg Leu Asp Leu Glu  Gly Asn Glu Tyr Pro  Ile His Ser 
    1010                 1015                 1020             


Thr Pro  Asn Cys His Asp His  Glu Arg Asn His Lys  Val Pro Pro 
    1025                 1030                 1035             


Pro Ile  Lys Pro Lys Pro Val  Val Pro Lys Thr Asn  Val Lys Lys 
    1040                 1045                 1050             


Leu Asp  Pro Asn Leu Leu Lys  Thr Ile Glu Ala Gly  Ile Gly Lys 
    1055                 1060                 1065             


Asn Pro  Arg Lys Gln Thr Ser  Arg Val Pro Leu Ala  His Pro Glu 
    1070                 1075                 1080             


Asp Met  Asp Pro Ser Asp Asn  Tyr Ala Glu Pro Ile  Asp Thr Ile 
    1085                 1090                 1095             


Phe Lys  Gln Lys Gly Tyr Ser  Asp Glu Ile Tyr Val  Val Pro Asp 
    1100                 1105                 1110             


Asp Ser  Gln Asn Arg Ile Lys  Ile Arg Asn Ser Phe  Val Asn Asn 
    1115                 1120                 1125             


Thr Gln  Gly Asp Glu Glu Asn  Gly Phe Ser Asp Arg  Thr Ser Lys 
    1130                 1135                 1140             


Ser His  Gly Glu Arg Arg Pro  Ser Lys Tyr Lys Tyr  Lys Ser Lys 
    1145                 1150                 1155             


Thr Leu  Phe Ser Lys Ala Lys  Ser Tyr Tyr Arg Arg  Thr His Ser 
    1160                 1165                 1170             


Asp Ala  Ser Asp Asp Glu Ala  Phe Thr Thr Ser Lys  Thr Lys Arg 
    1175                 1180                 1185             


Lys Gly  Arg His Arg Gly Ser  Glu Glu Asp Pro Leu  Leu Ser Pro 
    1190                 1195                 1200             


Val Glu  Thr Trp Lys Gly Gly  Ile Asp Asn Pro Ala  Ile Thr Ser 
    1205                 1210                 1215             


Asp Gln  Glu Leu Asp Asp Lys  Lys Met Lys Lys Lys  Thr His Lys 
    1220                 1225                 1230             


Val Lys  Glu Asp Lys Lys Lys  Lys Lys Thr Lys Asn  Phe Asn Pro 
    1235                 1240                 1245             


Pro Thr  Arg Arg Asn Trp Glu  Ser Asn Tyr Phe Gly  Met Pro Leu 
    1250                 1255                 1260             


Gln Asp  Leu Val Thr Ala Glu  Lys Pro Ile Pro Leu  Phe Val Glu 
    1265                 1270                 1275             


Lys Cys  Val Glu Phe Ile Glu  Asp Thr Gly Leu Cys  Thr Glu Gly 
    1280                 1285                 1290             


Leu Tyr  Arg Val Ser Gly Asn  Lys Thr Asp Gln Asp  Asn Ile Gln 
    1295                 1300                 1305             


Lys Gln  Phe Asp Gln Asp His  Asn Ile Asn Leu Val  Ser Met Glu 
    1310                 1315                 1320             


Val Thr  Val Asn Ala Val Ala  Gly Ala Leu Lys Ala  Phe Phe Ala 
    1325                 1330                 1335             


Asp Leu  Pro Asp Pro Leu Ile  Pro Tyr Ser Leu His  Pro Glu Leu 
    1340                 1345                 1350             


Leu Glu  Ala Ala Lys Ile Pro  Asp Lys Thr Glu Arg  Leu His Ala 
    1355                 1360                 1365             


Leu Lys  Glu Ile Val Lys Lys  Phe His Pro Val Asn  Tyr Asp Val 
    1370                 1375                 1380             


Phe Arg  Tyr Val Ile Thr His  Leu Asn Arg Val Ser  Gln Gln His 
    1385                 1390                 1395             


Lys Ile  Asn Leu Met Thr Ala  Asp Asn Leu Ser Ile  Cys Phe Trp 
    1400                 1405                 1410             


Pro Thr  Leu Met Arg Pro Asp  Phe Glu Asn Arg Glu  Phe Leu Ser 
    1415                 1420                 1425             


Thr Thr  Lys Ile His Gln Ser  Val Val Glu Thr Phe  Ile Gln Gln 
    1430                 1435                 1440             


Cys Gln  Phe Phe Phe Tyr Asn  Gly Glu Ile Val Glu  Thr Thr Asn 
    1445                 1450                 1455             


Ile Val  Ala Pro Pro Pro Pro  Ser Asn Pro Gly Gln  Leu Val Glu 
    1460                 1465                 1470             


Pro Met  Val Pro Leu Gln Leu  Pro Pro Pro Leu Gln  Pro Gln Leu 
    1475                 1480                 1485             


Ile Gln  Pro Gln Leu Gln Thr  Asp Pro Leu Gly Ile  Ile 
    1490                 1495                 1500     


<210>  1432
<211>  776
<212>  PRT
<213>  homo sapiens

<400>  1432

Met Asn Pro Glu Glu Gln Ile Val Thr Trp Leu Ile Ser Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Thr Ile Cys Asp Pro Glu Glu Phe Leu Lys 
            20                  25                  30          


Ser Ser Leu Lys Asn Gly Val Val Leu Cys Lys Leu Ile Asn Arg Leu 
        35                  40                  45              


Met Pro Gly Ser Val Glu Lys Phe Cys Leu Asp Pro Gln Thr Glu Ala 
    50                  55                  60                  


Asp Cys Ile Asn Asn Ile Asn Asp Phe Leu Lys Gly Cys Ala Thr Leu 
65                  70                  75                  80  


Gln Val Glu Ile Phe Asp Pro Asp Asp Leu Tyr Ser Gly Val Asn Phe 
                85                  90                  95      


Ser Lys Val Leu Ser Thr Leu Leu Ala Val Asn Lys Ala Thr Glu Asp 
            100                 105                 110         


Gln Leu Ser Glu Arg Pro Cys Gly Arg Ser Ser Ser Leu Ser Ala Ala 
        115                 120                 125             


Asn Thr Ser Gln Thr Asn Pro Gln Gly Ala Val Ser Ser Thr Val Ser 
    130                 135                 140                 


Gly Leu Gln Arg Gln Ser Lys Thr Val Glu Met Thr Glu Asn Gly Ser 
145                 150                 155                 160 


His Gln Leu Ile Val Lys Ala Arg Phe Asn Phe Lys Gln Thr Asn Glu 
                165                 170                 175     


Asp Glu Leu Ser Val Cys Lys Gly Asp Ile Ile Tyr Val Thr Arg Val 
            180                 185                 190         


Glu Glu Gly Gly Trp Trp Glu Gly Thr Leu Asn Gly Arg Thr Gly Trp 
        195                 200                 205             


Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys Ser Ser Glu Arg Pro Leu 
    210                 215                 220                 


Ser Pro Lys Ala Val Lys Gly Phe Glu Thr Ala Pro Leu Thr Lys Asn 
225                 230                 235                 240 


Tyr Tyr Thr Val Val Leu Gln Asn Ile Leu Asp Thr Glu Lys Glu Tyr 
                245                 250                 255     


Ala Lys Glu Leu Gln Ser Leu Leu Val Thr Tyr Leu Arg Pro Leu Gln 
            260                 265                 270         


Ser Asn Asn Asn Leu Ser Thr Val Glu Val Thr Ser Leu Leu Gly Asn 
        275                 280                 285             


Phe Glu Glu Val Cys Thr Phe Gln Gln Thr Leu Cys Gln Ala Leu Glu 
    290                 295                 300                 


Glu Cys Ser Lys Phe Pro Glu Asn Gln His Lys Val Gly Gly Cys Leu 
305                 310                 315                 320 


Leu Ser Leu Met Pro His Phe Lys Ser Met Tyr Leu Ala Tyr Cys Ala 
                325                 330                 335     


Asn His Pro Ser Ala Val Asn Val Leu Thr Gln His Ser Asp Glu Leu 
            340                 345                 350         


Glu Gln Phe Met Glu Asn Gln Gly Ala Ser Ser Pro Gly Ile Leu Ile 
        355                 360                 365             


Leu Thr Thr Asn Leu Ser Lys Pro Phe Met Arg Leu Glu Lys Tyr Val 
    370                 375                 380                 


Thr Leu Leu Gln Glu Leu Glu Arg His Met Glu Asp Thr His Pro Asp 
385                 390                 395                 400 


His Gln Asp Ile Leu Lys Ala Ile Val Ala Phe Lys Thr Leu Met Gly 
                405                 410                 415     


Gln Cys Gln Asp Leu Arg Lys Arg Lys Gln Leu Glu Leu Gln Ile Leu 
            420                 425                 430         


Ser Glu Pro Ile Gln Ala Trp Glu Gly Glu Asp Ile Lys Asn Leu Gly 
        435                 440                 445             


Asn Val Ile Phe Met Ser Gln Val Met Val Gln Tyr Gly Ala Cys Glu 
    450                 455                 460                 


Glu Lys Glu Glu Arg Tyr Leu Met Leu Phe Ser Asn Val Leu Ile Met 
465                 470                 475                 480 


Leu Ser Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Ile 
                485                 490                 495     


Pro Ile Ala Gly Thr Val Val Thr Arg Leu Asp Glu Ile Glu Gly Asn 
            500                 505                 510         


Asp Cys Thr Phe Glu Ile Thr Gly Asn Thr Val Glu Arg Ile Val Val 
        515                 520                 525             


His Cys Asn Asn Asn Gln Asp Phe Gln Glu Trp Leu Glu Gln Leu Asn 
    530                 535                 540                 


Arg Leu Ile Arg Gly Pro Ala Ser Cys Ser Ser Leu Ser Lys Thr Ser 
545                 550                 555                 560 


Ser Ser Ser Cys Ser Ala His Ser Ser Phe Ser Ser Thr Gly Gln Pro 
                565                 570                 575     


Arg Gly Pro Leu Glu Pro Pro Gln Ile Ile Lys Pro Trp Ser Leu Ser 
            580                 585                 590         


Cys Leu Arg Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Gly Tyr 
        595                 600                 605             


Lys Glu Arg Met Ser Tyr Ile Leu Lys Glu Ser Ser Lys Ser Pro Lys 
    610                 615                 620                 


Thr Met Lys Lys Phe Leu His Lys Arg Lys Thr Glu Arg Lys Pro Ser 
625                 630                 635                 640 


Glu Glu Glu Tyr Val Ile Arg Lys Ser Thr Ala Ala Leu Glu Glu Asp 
                645                 650                 655     


Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Thr Ser Ala Asn Phe 
            660                 665                 670         


Gln Gln Gly His Gly Ser Ser Thr Arg Lys Asp Ser Ile Pro Gln Val 
        675                 680                 685             


Leu Leu Pro Glu Glu Glu Lys Leu Ile Ile Glu Glu Thr Arg Ser Asn 
    690                 695                 700                 


Gly Gln Thr Ile Met Glu Glu Lys Ser Leu Val Asp Thr Val Tyr Ala 
705                 710                 715                 720 


Leu Lys Asp Glu Val Arg Glu Leu Lys Gln Glu Asn Lys Arg Met Lys 
                725                 730                 735     


Gln Cys Leu Glu Glu Glu Leu Lys Ser Arg Arg Asp Leu Glu Lys Leu 
            740                 745                 750         


Val Arg Arg Leu Leu Lys Gln Thr Asp Glu Cys Ile Arg Gly Glu Ser 
        755                 760                 765             


Ser Ser Lys Thr Ser Ile Leu Pro 
    770                 775     


<210>  1433
<211>  188
<212>  PRT
<213>  homo sapiens

<400>  1433

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Thr 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210>  1434
<211>  2202
<212>  PRT
<213>  homo sapiens

<400>  1434

Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Thr Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Thr Phe His Leu Lys Asp Ser Val Gly His Lys Glu Thr 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Thr 
        115                 120                 125             


Ala Ala Cys Asn Ala Thr Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Thr Ala Leu Val Gln Met Thr Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Thr Gln Lys Thr Ile 
            180                 185                 190         


Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys 
        195                 200                 205             


Thr Pro Glu Leu Lys Pro Val Glu Lys Thr Asn Gly Ser Phe Leu Trp 
    210                 215                 220                 


Cys Glu Val Glu Lys Tyr Leu Asn Ser Thr Leu Lys Glu Met Thr Glu 
225                 230                 235                 240 


Val Pro Arg Val Glu Asp Leu Cys Cys Thr Leu Tyr Asp Met Leu Ala 
                245                 250                 255     


Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile 
        275                 280                 285             


Thr Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln 
    290                 295                 300                 


Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro 
305                 310                 315                 320 


Asn Tyr Gly Cys Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu 
                325                 330                 335     


Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys 
            340                 345                 350         


Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp 
        355                 360                 365             


Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg 
    370                 375                 380                 


Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile 
385                 390                 395                 400 


His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser 
                405                 410                 415     


Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg 
            420                 425                 430         


Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro 
        435                 440                 445             


Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp 
    450                 455                 460                 


Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile 
465                 470                 475                 480 


Gln Ser Ile Val Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu 
                485                 490                 495     


Ile Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr 
            500                 505                 510         


Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys 
        515                 520                 525             


Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala 
    530                 535                 540                 


Glu Met Thr Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile 
545                 550                 555                 560 


Val Lys Glu Leu Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu 
                565                 570                 575     


Arg Thr Gln Met Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr 
            580                 585                 590         


Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu 
        595                 600                 605             


Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu 
    610                 615                 620                 


Glu Ser Ile Val Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser 
625                 630                 635                 640 


Met Ile Arg Ile Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp 
                645                 650                 655     


Val Ala Thr Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe 
            660                 665                 670         


Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile 
        675                 680                 685             


Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys 
    690                 695                 700                 


Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val 
705                 710                 715                 720 


Phe Val His Ala Arg Asn Ala Thr Val Arg Thr Ala Met Ser Leu Ile 
                725                 730                 735     


Glu Arg Ala Lys Asn Cys Gly His Ile Pro Phe Phe Phe Pro Thr Gln 
            740                 745                 750         


Gly His Asp Tyr Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn 
        755                 760                 765             


Lys Gln Val Arg Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala 
    770                 775                 780                 


Gly Met Leu Arg Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn 
785                 790                 795                 800 


Gly His Ile Lys Val Leu Val Cys Thr Ala Thr Leu Ala Trp Gly Val 
                805                 810                 815     


Asn Leu Pro Ala His Ala Val Ile Ile Lys Gly Thr Gln Ile Tyr Ala 
            820                 825                 830         


Ala Lys Arg Gly Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln 
        835                 840                 845             


Ile Phe Gly Arg Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly 
    850                 855                 860                 


Ile Ile Ile Thr Thr His Asp Lys Leu Ser His Tyr Leu Thr Leu Leu 
865                 870                 875                 880 


Thr Gln Arg Asn Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp 
                885                 890                 895     


Asn Leu Asn Ala Glu Ile Ala Leu Gly Thr Val Thr Asn Val Glu Glu 
            900                 905                 910         


Ala Val Lys Trp Ile Ser Tyr Thr Tyr Leu Tyr Val Arg Met Arg Ala 
        915                 920                 925             


Asn Pro Leu Ala Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro 
    930                 935                 940                 


Thr Leu Arg Lys His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys 
945                 950                 955                 960 


Leu Asp Lys Ala Gln Met Ile Arg Phe Glu Glu Arg Thr Gly Tyr Phe 
                965                 970                 975     


Ser Ser Thr Asp Leu Gly Arg Thr Ala Ser His Tyr Tyr Ile Lys Tyr 
            980                 985                 990         


Asn Thr Ile Glu Thr Phe Asn Glu  Leu Phe Asp Ala His  Lys Thr Glu 
        995                 1000                 1005             


Gly Asp  Ile Phe Ala Ile Val  Ser Lys Ala Glu Glu  Phe Asp Gln 
    1010                 1015                 1020             


Ile Lys  Val Arg Glu Glu Glu  Ile Glu Glu Leu Asp  Thr Leu Leu 
    1025                 1030                 1035             


Ser Asn  Phe Cys Glu Leu Ser  Thr Pro Gly Gly Val  Glu Asn Ser 
    1040                 1045                 1050             


Tyr Gly  Lys Ile Asn Ile Leu  Leu Gln Thr Tyr Ile  Ser Arg Gly 
    1055                 1060                 1065             


Glu Met  Asp Ser Phe Ser Leu  Ile Ser Asp Ser Ala  Tyr Val Ala 
    1070                 1075                 1080             


Gln Asn  Ala Ala Arg Ile Val  Arg Ala Leu Phe Glu  Ile Ala Leu 
    1085                 1090                 1095             


Arg Lys  Arg Trp Pro Thr Met  Thr Tyr Arg Leu Leu  Asn Leu Ser 
    1100                 1105                 1110             


Lys Val  Ile Asp Lys Arg Leu  Trp Gly Trp Ala Ser  Pro Leu Arg 
    1115                 1120                 1125             


Gln Phe  Ser Ile Leu Pro Pro  His Ile Leu Thr Arg  Leu Glu Glu 
    1130                 1135                 1140             


Lys Lys  Leu Thr Val Asp Lys  Leu Lys Asp Met Arg  Lys Asp Glu 
    1145                 1150                 1155             


Ile Gly  His Ile Leu His His  Val Asn Ile Gly Leu  Lys Val Lys 
    1160                 1165                 1170             


Gln Cys  Val His Gln Ile Pro  Ser Val Met Met Glu  Ala Ser Ile 
    1175                 1180                 1185             


Gln Pro  Ile Thr Arg Thr Val  Leu Arg Val Thr Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Ala Asp  Phe Thr Trp Asn Asp  Gln Val His Gly Thr  Val Gly Glu 
    1205                 1210                 1215             


Pro Trp  Trp Ile Trp Val Glu  Asp Pro Thr Asn Asp  His Ile Tyr 
    1220                 1225                 1230             


His Ser  Glu Tyr Phe Leu Ala  Leu Lys Lys Gln Val  Ile Ser Lys 
    1235                 1240                 1245             


Glu Ala  Gln Leu Leu Val Phe  Thr Ile Pro Ile Phe  Glu Pro Leu 
    1250                 1255                 1260             


Pro Ser  Gln Tyr Tyr Ile Arg  Ala Val Ser Asp Arg  Trp Leu Gly 
    1265                 1270                 1275             


Ala Glu  Ala Val Cys Ile Ile  Asn Phe Gln His Leu  Ile Leu Pro 
    1280                 1285                 1290             


Glu Arg  His Pro Pro His Thr  Glu Leu Leu Asp Leu  Gln Pro Leu 
    1295                 1300                 1305             


Pro Ile  Thr Ala Leu Gly Cys  Lys Ala Tyr Glu Ala  Leu Tyr Asn 
    1310                 1315                 1320             


Phe Ser  His Phe Asn Pro Val  Gln Thr Gln Ile Phe  His Thr Leu 
    1325                 1330                 1335             


Tyr His  Thr Asp Cys Asn Val  Leu Leu Gly Ala Pro  Thr Gly Ser 
    1340                 1345                 1350             


Gly Lys  Thr Val Ala Ala Glu  Leu Ala Ile Phe Arg  Val Phe Asn 
    1355                 1360                 1365             


Lys Tyr  Pro Thr Ser Lys Ala  Val Tyr Ile Ala Pro  Leu Lys Ala 
    1370                 1375                 1380             


Leu Val  Arg Glu Arg Met Asp  Asp Trp Lys Val Arg  Ile Glu Glu 
    1385                 1390                 1395             


Lys Leu  Gly Lys Lys Val Ile  Glu Leu Thr Gly Asp  Val Thr Pro 
    1400                 1405                 1410             


Asp Met  Lys Ser Ile Ala Lys  Ala Asp Leu Ile Val  Thr Thr Pro 
    1415                 1420                 1425             


Glu Lys  Trp Asp Gly Val Ser  Arg Ser Trp Gln Asn  Arg Asn Tyr 
    1430                 1435                 1440             


Val Gln  Gln Val Thr Ile Leu  Ile Ile Asp Glu Ile  His Leu Leu 
    1445                 1450                 1455             


Gly Glu  Glu Arg Gly Pro Val  Leu Glu Val Ile Val  Ser Arg Thr 
    1460                 1465                 1470             


Asn Phe  Ile Ser Ser His Thr  Glu Lys Pro Val Arg  Ile Val Gly 
    1475                 1480                 1485             


Leu Ser  Thr Ala Leu Ala Asn  Ala Arg Asp Leu Ala  Asp Trp Leu 
    1490                 1495                 1500             


Asn Ile  Lys Gln Met Gly Leu  Phe Asn Phe Arg Pro  Ser Val Arg 
    1505                 1510                 1515             


Pro Val  Pro Leu Glu Val His  Ile Gln Gly Phe Pro  Gly Gln His 
    1520                 1525                 1530             


Tyr Cys  Pro Arg Met Ala Ser  Met Asn Lys Pro Ala  Phe Gln Ala 
    1535                 1540                 1545             


Ile Arg  Ser His Ser Pro Ala  Lys Pro Val Leu Ile  Phe Val Ser 
    1550                 1555                 1560             


Ser Arg  Arg Gln Thr Arg Leu  Thr Ala Leu Glu Leu  Ile Ala Phe 
    1565                 1570                 1575             


Leu Ala  Thr Glu Glu Asp Pro  Lys Gln Trp Leu Asn  Met Asp Glu 
    1580                 1585                 1590             


Arg Glu  Met Glu Asn Ile Ile  Ala Thr Val Arg Asp  Ser Asn Leu 
    1595                 1600                 1605             


Lys Leu  Thr Leu Ala Phe Gly  Ile Gly Met His His  Ala Gly Leu 
    1610                 1615                 1620             


His Glu  Arg Asp Arg Lys Thr  Val Glu Glu Leu Phe  Val Asn Cys 
    1625                 1630                 1635             


Lys Val  Gln Val Leu Ile Ala  Thr Ser Thr Leu Ala  Trp Gly Val 
    1640                 1645                 1650             


Asn Phe  Pro Ala His Leu Val  Ile Ile Lys Gly Thr  Glu Tyr Tyr 
    1655                 1660                 1665             


Asp Gly  Lys Thr Arg Arg Tyr  Val Asp Phe Pro Ile  Thr Asp Val 
    1670                 1675                 1680             


Leu Gln  Met Met Gly Arg Ala  Gly Arg Pro Gln Phe  Asp Asp Gln 
    1685                 1690                 1695             


Gly Lys  Ala Val Ile Leu Val  His Asp Ile Lys Lys  Asp Phe Tyr 
    1700                 1705                 1710             


Lys Lys  Phe Leu Tyr Glu Pro  Phe Pro Val Glu Ser  Ser Leu Leu 
    1715                 1720                 1725             


Gly Val  Leu Ser Asp His Leu  Asn Ala Glu Ile Ala  Gly Gly Thr 
    1730                 1735                 1740             


Ile Thr  Ser Lys Gln Asp Ala  Leu Asp Tyr Ile Thr  Trp Thr Tyr 
    1745                 1750                 1755             


Phe Phe  Arg Arg Leu Ile Met  Asn Pro Ser Tyr Tyr  Asn Leu Gly 
    1760                 1765                 1770             


Asp Val  Ser His Asp Ser Val  Asn Lys Phe Leu Ser  His Leu Ile 
    1775                 1780                 1785             


Glu Lys  Ser Leu Ile Glu Leu  Glu Leu Ser Tyr Cys  Ile Glu Ile 
    1790                 1795                 1800             


Gly Glu  Asp Asn Arg Ser Ile  Glu Pro Leu Thr Tyr  Gly Arg Ile 
    1805                 1810                 1815             


Ala Ser  Tyr Tyr Tyr Leu Lys  His Gln Thr Val Lys  Met Phe Lys 
    1820                 1825                 1830             


Asp Arg  Leu Lys Pro Glu Cys  Ser Thr Glu Glu Leu  Leu Ser Ile 
    1835                 1840                 1845             


Leu Ser  Asp Ala Glu Glu Tyr  Thr Asp Leu Pro Val  Arg His Asn 
    1850                 1855                 1860             


Glu Asp  His Met Asn Ser Glu  Leu Ala Lys Cys Leu  Pro Ile Glu 
    1865                 1870                 1875             


Ser Asn  Pro His Ser Phe Asp  Ser Pro His Thr Lys  Ala His Leu 
    1880                 1885                 1890             


Leu Leu  Gln Ala His Leu Ser  Arg Ala Met Leu Pro  Cys Pro Asp 
    1895                 1900                 1905             


Tyr Asp  Thr Asp Thr Lys Thr  Val Leu Asp Gln Ala  Leu Arg Val 
    1910                 1915                 1920             


Cys Gln  Ala Met Leu Asp Val  Ala Ala Asn Gln Gly  Trp Leu Val 
    1925                 1930                 1935             


Thr Val  Leu Asn Ile Thr Asn  Leu Ile Gln Met Val  Ile Gln Gly 
    1940                 1945                 1950             


Arg Trp  Leu Lys Asp Ser Ser  Leu Leu Thr Leu Pro  Asn Ile Glu 
    1955                 1960                 1965             


Asn His  His Leu His Leu Phe  Lys Lys Trp Lys Pro  Ile Met Lys 
    1970                 1975                 1980             


Gly Pro  His Ala Arg Gly Arg  Thr Ser Ile Glu Ser  Leu Pro Glu 
    1985                 1990                 1995             


Leu Ile  His Ala Cys Gly Gly  Lys Asp His Val Phe  Ser Ser Met 
    2000                 2005                 2010             


Val Glu  Ser Glu Leu His Ala  Ala Lys Thr Lys Gln  Ala Trp Asn 
    2015                 2020                 2025             


Phe Leu  Ser His Leu Pro Val  Ile Asn Val Gly Ile  Ser Val Lys 
    2030                 2035                 2040             


Gly Ser  Trp Asp Asp Leu Val  Glu Gly His Asn Glu  Leu Ser Val 
    2045                 2050                 2055             


Ser Thr  Leu Thr Ala Asp Lys  Arg Asp Asp Asn Lys  Trp Ile Lys 
    2060                 2065                 2070             


Leu His  Ala Asp Gln Glu Tyr  Val Leu Gln Val Ser  Leu Gln Arg 
    2075                 2080                 2085             


Val His  Phe Gly Phe His Lys  Gly Lys Pro Glu Ser  Cys Ala Val 
    2090                 2095                 2100             


Thr Pro  Arg Phe Pro Lys Ser  Lys Asp Glu Gly Trp  Phe Leu Ile 
    2105                 2110                 2115             


Leu Gly  Glu Val Asp Lys Arg  Glu Leu Ile Ala Leu  Lys Arg Val 
    2120                 2125                 2130             


Gly Tyr  Ile Arg Asn His His  Val Ala Ser Leu Ser  Phe Tyr Thr 
    2135                 2140                 2145             


Pro Glu  Ile Pro Gly Arg Tyr  Ile Tyr Thr Leu Tyr  Phe Met Ser 
    2150                 2155                 2160             


Asp Cys  Tyr Leu Gly Leu Asp  Gln Gln Tyr Asp Ile  Tyr Leu Asn 
    2165                 2170                 2175             


Val Thr  Gln Ala Ser Leu Ser  Ala Gln Val Asn Thr  Lys Val Ser 
    2180                 2185                 2190             


Asp Ser  Leu Thr Asp Leu Ala  Leu Lys 
    2195                 2200         


<210>  1435
<211>  1164
<212>  PRT
<213>  homo sapiens

<400>  1435

Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu 
1               5                   10                  15      


Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp 
            20                  25                  30          


Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys 
        35                  40                  45              


Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe 
    50                  55                  60                  


Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe 
65                  70                  75                  80  


Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr 
                85                  90                  95      


Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala 
            100                 105                 110         


Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn 
        115                 120                 125             


Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu 
    130                 135                 140                 


Ile Val His Trp Glu Lys Val Ala Val Gly Glu Ile Val Lys Val Thr 
145                 150                 155                 160 


Asn Gly Glu His Leu Pro Ala Asp Leu Ile Ser Leu Ser Ser Ser Glu 
                165                 170                 175     


Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr 
            180                 185                 190         


Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp 
        195                 200                 205             


Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro 
    210                 215                 220                 


Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His 
225                 230                 235                 240 


Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln 
                245                 250                 255     


Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His 
            260                 265                 270         


Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser 
        275                 280                 285             


Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile 
    290                 295                 300                 


Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn 
305                 310                 315                 320 


Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly 
                325                 330                 335     


Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn 
            340                 345                 350         


Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe 
        355                 360                 365             


Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro 
    370                 375                 380                 


Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu 
385                 390                 395                 400 


Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys 
                405                 410                 415     


Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly 
            420                 425                 430         


His Val Pro Glu Pro Glu Asp Tyr Gly Cys Ser Pro Asp Glu Trp Gln 
        435                 440                 445             


Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu Leu 
    450                 455                 460                 


Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu Phe 
465                 470                 475                 480 


Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu Gly 
                485                 490                 495     


Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val 
            500                 505                 510         


Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro Asp 
        515                 520                 525             


Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu Leu 
    530                 535                 540                 


Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile Val 
545                 550                 555                 560 


Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp Thr 
                565                 570                 575     


Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile Thr 
            580                 585                 590         


Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu Cys 
        595                 600                 605             


Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg Ala 
    610                 615                 620                 


Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys Leu 
625                 630                 635                 640 


Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly Ala 
                645                 650                 655     


Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile Glu 
            660                 665                 670         


Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp Lys 
        675                 680                 685             


Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys Lys 
    690                 695                 700                 


Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr Arg 
705                 710                 715                 720 


Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg Lys 
                725                 730                 735     


Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr Ala 
            740                 745                 750         


Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser Cys 
        755                 760                 765             


Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu Val 
    770                 775                 780                 


Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile Gly 
785                 790                 795                 800 


Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly Val 
                805                 810                 815     


Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp Tyr 
            820                 825                 830         


Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His Gly 
        835                 840                 845             


Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe Tyr 
    850                 855                 860                 


Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val Asn 
865                 870                 875                 880 


Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu Tyr 
                885                 890                 895     


Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe Glu 
            900                 905                 910         


Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr Lys 
        915                 920                 925             


Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val His 
    930                 935                 940                 


Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro Leu 
945                 950                 955                 960 


Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser Asp 
                965                 970                 975     


Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr Val 
            980                 985                 990         


Cys Leu Lys Ala Gly Leu Glu Thr  Ser Tyr Trp Thr Trp  Phe Ser His 
        995                 1000                 1005             


Ile Ala  Ile Trp Gly Ser Ile  Ala Leu Trp Val Val  Phe Phe Gly 
    1010                 1015                 1020             


Ile Tyr  Ser Ser Leu Trp Pro  Ala Ile Pro Met Ala  Pro Asp Met 
    1025                 1030                 1035             


Ser Gly  Glu Ala Ala Met Leu  Phe Ser Ser Gly Val  Phe Trp Met 
    1040                 1045                 1050             


Gly Leu  Leu Phe Ile Pro Val  Ala Ser Leu Leu Leu  Asp Val Val 
    1055                 1060                 1065             


Tyr Lys  Val Ile Lys Arg Thr  Ala Phe Lys Thr Leu  Val Asp Glu 
    1070                 1075                 1080             


Val Gln  Glu Leu Glu Ala Lys  Ser Gln Asp Pro Gly  Ala Val Val 
    1085                 1090                 1095             


Leu Gly  Lys Ser Leu Thr Glu  Arg Ala Gln Leu Leu  Lys Asn Val 
    1100                 1105                 1110             


Phe Lys  Lys Asn His Val Asn  Leu Tyr Arg Ser Glu  Ser Leu Gln 
    1115                 1120                 1125             


Gln Asn  Leu Leu His Gly Tyr  Ala Phe Ser Gln Asp  Glu Asn Gly 
    1130                 1135                 1140             


Ile Val  Ser Gln Ser Glu Val  Ile Arg Ala Tyr Asp  Thr Thr Lys 
    1145                 1150                 1155             


Gln Arg  Pro Asp Glu Trp 
    1160                 


<210>  1436
<211>  361
<212>  PRT
<213>  homo sapiens

<400>  1436

Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser 
                85                  90                  95      


Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys 
        115                 120                 125             


Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr 
145                 150                 155                 160 


Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu Ile 
            180                 185                 190         


Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr Asp 
        195                 200                 205             


Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu Ile 
225                 230                 235                 240 


Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu Ser 
                245                 250                 255     


Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr Ser 
            260                 265                 270         


Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala Tyr 
        275                 280                 285             


Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gly Asp Leu Ser Gly Gln Ser Ser His Pro Cys Glu Arg Pro Ala 
305                 310                 315                 320 


Thr Ser Ser Gly Ala Leu Gly Ser Asp Leu Gly Asp Ala Met Ser Glu 
                325                 330                 335     


Glu Asp Met Leu Gln Ala Ala Val Thr Met Ser Leu Glu Thr Val Arg 
            340                 345                 350         


Asn Asp Leu Lys Thr Glu Gly Lys Lys 
        355                 360     


<210>  1437
<211>  392
<212>  PRT
<213>  homo sapiens

<400>  1437

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu 
    210                 215                 220                 


Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro 
225                 230                 235                 240 


Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr 
                245                 250                 255     


Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val 
            260                 265                 270         


Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala 
        275                 280                 285             


Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu 
    290                 295                 300                 


Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile 
305                 310                 315                 320 


Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly 
                325                 330                 335     


Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn 
            340                 345                 350         


Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro 
        355                 360                 365             


His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp 
    370                 375                 380                 


Ala Leu Arg Lys Met Ile Asn Tyr 
385                 390         


<210>  1438
<211>  316
<212>  PRT
<213>  homo sapiens

<400>  1438

Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser 
1               5                   10                  15      


Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu 
            20                  25                  30          


Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser 
        35                  40                  45              


Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu 
    50                  55                  60                  


Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu 
65                  70                  75                  80  


Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln 
                85                  90                  95      


Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly 
            100                 105                 110         


Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr 
        115                 120                 125             


Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met 
    130                 135                 140                 


Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile 
                165                 170                 175     


Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly Pro Arg Asp Phe Trp 
            180                 185                 190         


Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln Lys Glu Glu Glu Arg 
        195                 200                 205             


Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val Pro His Val Thr Ile 
    210                 215                 220                 


Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu Pro Lys Ile Leu Cys 
225                 230                 235                 240 


Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His Ser Leu Thr His Leu 
                245                 250                 255     


Asp Ser Val Thr Lys Ile His Asn Gly Ser Val Phe Thr Lys Asn Leu 
            260                 265                 270         


Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu Leu Gln Trp Leu Glu 
        275                 280                 285             


Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln Glu Leu Gln Gln Glu 
    290                 295                 300                 


Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu Glu 
305                 310                 315     


<210>  1439
<211>  527
<212>  PRT
<213>  homo sapiens

<400>  1439

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210>  1440
<211>  419
<212>  PRT
<213>  homo sapiens

<400>  1440

Met Asn Lys His Gln Lys Pro Val Leu Thr Gly Gln Arg Phe Lys Thr 
1               5                   10                  15      


Arg Lys Arg Asp Glu Lys Glu Lys Phe Glu Pro Thr Val Phe Arg Asp 
            20                  25                  30          


Thr Leu Val Gln Gly Leu Asn Glu Ala Gly Asp Asp Leu Glu Ala Val 
        35                  40                  45              


Ala Lys Phe Leu Asp Ser Thr Gly Ser Arg Leu Asp Tyr Arg Arg Tyr 
    50                  55                  60                  


Ala Asp Thr Leu Phe Asp Ile Leu Val Ala Gly Ser Met Leu Ala Pro 
65                  70                  75                  80  


Gly Gly Thr Arg Ile Asp Asp Gly Asp Lys Thr Lys Met Thr Asn His 
                85                  90                  95      


Cys Val Phe Ser Ala Asn Glu Asp His Glu Thr Ile Arg Asn Tyr Ala 
            100                 105                 110         


Gln Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Ala 
        115                 120                 125             


Phe Glu Asp Glu Met Lys Lys Leu Leu Leu Phe Leu Lys Ala Phe Ser 
    130                 135                 140                 


Glu Thr Glu Gln Thr Lys Leu Ala Met Leu Ser Gly Ile Leu Leu Gly 
145                 150                 155                 160 


Asn Gly Thr Leu Pro Ala Thr Ile Leu Thr Ser Leu Phe Thr Asp Ser 
                165                 170                 175     


Leu Val Lys Glu Gly Ile Ala Ala Ser Phe Ala Val Lys Leu Phe Lys 
            180                 185                 190         


Ala Trp Met Ala Glu Lys Asp Ala Asn Ser Val Thr Ser Ser Leu Arg 
        195                 200                 205             


Lys Ala Asn Leu Asp Lys Arg Leu Leu Glu Leu Phe Pro Val Asn Arg 
    210                 215                 220                 


Gln Ser Val Asp His Phe Ala Lys Tyr Phe Thr Asp Ala Gly Leu Lys 
225                 230                 235                 240 


Glu Leu Ser Asp Phe Leu Arg Val Gln Gln Ser Leu Gly Thr Arg Lys 
                245                 250                 255     


Glu Leu Gln Lys Glu Leu Gln Glu Arg Leu Ser Gln Glu Cys Pro Ile 
            260                 265                 270         


Lys Glu Val Val Leu Tyr Val Lys Glu Glu Met Lys Arg Asn Asp Leu 
        275                 280                 285             


Pro Glu Thr Ala Val Ile Gly Leu Leu Trp Thr Cys Ile Met Asn Ala 
    290                 295                 300                 


Val Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Leu Lys 
305                 310                 315                 320 


His Leu Lys Gln Tyr Ala Pro Leu Leu Ala Val Phe Ser Ser Gln Gly 
                325                 330                 335     


Gln Ser Glu Leu Ile Leu Leu Gln Lys Val Gln Glu Tyr Cys Tyr Asp 
            340                 345                 350         


Asn Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr 
        355                 360                 365             


Lys Ala Asp Val Leu Ser Glu Glu Ala Ile Leu Lys Trp Tyr Lys Glu 
    370                 375                 380                 


Ala His Val Ala Lys Gly Lys Ser Val Phe Leu Asp Gln Met Lys Lys 
385                 390                 395                 400 


Phe Val Glu Trp Leu Gln Asn Ala Glu Glu Glu Ser Glu Ser Glu Gly 
                405                 410                 415     


Glu Glu Asn 
            


<210>  1441
<211>  140
<212>  PRT
<213>  homo sapiens

<400>  1441

Met Ser Arg Phe Leu Asn Val Leu Arg Ser Trp Leu Val Met Val Ser 
1               5                   10                  15      


Ile Ile Ala Met Gly Asn Thr Leu Gln Ser Phe Arg Asp His Thr Phe 
            20                  25                  30          


Leu Tyr Glu Lys Leu Tyr Thr Gly Lys Pro Asn Leu Val Asn Gly Leu 
        35                  40                  45              


Gln Ala Arg Thr Phe Gly Ile Trp Thr Leu Leu Ser Ser Val Ile Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ile Asp Ile His Asn Lys Thr Leu Tyr His Ile Thr 
65                  70                  75                  80  


Leu Trp Thr Phe Leu Leu Ala Leu Gly His Phe Leu Ser Glu Leu Phe 
                85                  90                  95      


Val Tyr Gly Thr Ala Ala Pro Thr Ile Gly Val Leu Ala Pro Leu Met 
            100                 105                 110         


Val Ala Ser Phe Ser Ile Leu Gly Met Leu Val Gly Leu Arg Tyr Leu 
        115                 120                 125             


Glu Val Glu Pro Val Ser Arg Gln Lys Lys Arg Asn 
    130                 135                 140 


<210>  1442
<211>  220
<212>  PRT
<213>  homo sapiens

<400>  1442

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  1443
<211>  261
<212>  PRT
<213>  homo sapiens

<400>  1443

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  1444
<211>  328
<212>  PRT
<213>  homo sapiens

<400>  1444

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210>  1445
<211>  146
<212>  PRT
<213>  homo sapiens

<400>  1445

Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln 
145     


<210>  1446
<211>  326
<212>  PRT
<213>  homo sapiens

<400>  1446

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  1447
<211>  198
<212>  PRT
<213>  homo sapiens

<400>  1447

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  1448
<211>  682
<212>  PRT
<213>  homo sapiens

<400>  1448

Met Ser Thr Pro Ala Val Pro Gln Asp Leu Gln Leu Pro Pro Ser Gln 
1               5                   10                  15      


Arg Ala Gln Ser Ala Phe Lys Glu Gln Arg Arg Gln Lys Leu Lys Glu 
            20                  25                  30          


His Leu Leu Arg Arg Lys Thr Leu Phe Ala Tyr Lys Gln Glu Asn Glu 
        35                  40                  45              


Met Leu Ser Ser Arg Asp Gln Arg Val Val Thr Ser Glu Asp Gln Val 
    50                  55                  60                  


Gln Glu Gly Thr Lys Val Leu Lys Leu Lys Thr Lys Met Ala Asp Lys 
65                  70                  75                  80  


Glu Asn Met Lys Arg Pro Ala Glu Ser Lys Asn Asn Thr Val Val Gly 
                85                  90                  95      


Lys His Cys Ile Pro Leu Lys Pro Ser Asn Glu Leu Thr Asn Ser Thr 
            100                 105                 110         


Val Val Ile Asp Thr His Lys Pro Lys Asp Ser Asn Gln Thr Pro His 
        115                 120                 125             


Leu Leu Leu Thr Glu Asp Asp Pro Gln Ser Gln His Met Thr Leu Ser 
    130                 135                 140                 


Gln Ala Phe His Leu Lys Asn Asn Ser Lys Lys Lys Gln Met Thr Thr 
145                 150                 155                 160 


Glu Lys Gln Lys Gln Asp Ala Asn Met Pro Lys Lys Pro Val Leu Gly 
                165                 170                 175     


Ser Tyr Arg Gly Gln Ile Val Gln Ser Lys Ile Asn Ser Phe Arg Lys 
            180                 185                 190         


Pro Leu Gln Val Lys Asp Glu Ser Ser Ala Ala Thr Lys Lys Leu Ser 
        195                 200                 205             


Ala Thr Ile Pro Lys Ala Thr Lys Pro Gln Pro Val Asn Thr Ser Ser 
    210                 215                 220                 


Val Thr Val Lys Ser Asn Arg Ser Ser Asn Met Thr Ala Thr Thr Lys 
225                 230                 235                 240 


Phe Val Ser Thr Thr Ser Gln Asn Thr Gln Leu Val Arg Pro Pro Ile 
                245                 250                 255     


Arg Ser His His Ser Asn Thr Arg Asp Thr Val Lys Gln Gly Ile Ser 
            260                 265                 270         


Arg Thr Ser Ala Asn Val Thr Ile Arg Lys Gly Pro His Glu Lys Glu 
        275                 280                 285             


Leu Leu Gln Ser Lys Thr Ala Leu Ser Ser Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gln Gly Ile Ile Arg Asn Lys Thr Leu Ser Arg Ser Ile Ala Ser Glu 
305                 310                 315                 320 


Val Ile Ala Arg Pro Ala Ser Leu Ser Asn Asp Lys Leu Met Glu Lys 
                325                 330                 335     


Ser Glu Pro Val Asp Gln Arg Arg His Thr Ala Gly Lys Ala Ile Val 
            340                 345                 350         


Asp Ser Arg Ser Ala Gln Pro Lys Glu Thr Ser Glu Glu Arg Lys Ala 
        355                 360                 365             


Arg Leu Ser Glu Trp Lys Ala Gly Lys Gly Arg Val Leu Lys Arg Pro 
    370                 375                 380                 


Pro Asn Ser Val Val Thr Gln His Glu Pro Ala Gly Gln Asn Glu Lys 
385                 390                 395                 400 


Pro Val Gly Ser Phe Trp Thr Thr Met Ala Glu Glu Asp Glu Gln Arg 
                405                 410                 415     


Leu Phe Thr Glu Lys Val Asn Asn Thr Phe Ser Glu Cys Leu Asn Leu 
            420                 425                 430         


Ile Asn Glu Gly Cys Pro Lys Glu Asp Ile Leu Val Thr Leu Asn Asp 
        435                 440                 445             


Leu Ile Lys Asn Ile Pro Asp Ala Lys Lys Leu Val Lys Tyr Trp Ile 
    450                 455                 460                 


Cys Leu Ala Leu Ile Glu Pro Ile Thr Ser Pro Ile Glu Asn Ile Ile 
465                 470                 475                 480 


Ala Ile Tyr Glu Lys Ala Ile Leu Ala Gly Ala Gln Pro Ile Glu Glu 
                485                 490                 495     


Met Arg His Thr Ile Val Asp Ile Leu Thr Met Lys Ser Gln Glu Lys 
            500                 505                 510         


Ala Asn Leu Gly Glu Asn Met Glu Lys Ser Cys Ala Ser Lys Glu Glu 
        515                 520                 525             


Val Lys Glu Val Ser Ile Glu Asp Thr Gly Val Asp Val Asp Pro Glu 
    530                 535                 540                 


Lys Leu Glu Met Glu Ser Lys Leu His Arg Asn Leu Leu Phe Gln Asp 
545                 550                 555                 560 


Cys Glu Lys Glu Gln Asp Asn Lys Thr Lys Asp Pro Thr His Asp Val 
                565                 570                 575     


Lys Thr Pro Asn Thr Glu Thr Arg Thr Ser Cys Leu Ile Lys Tyr Asn 
            580                 585                 590         


Val Ser Thr Thr Pro Tyr Leu Gln Ser Val Lys Lys Lys Val Gln Phe 
        595                 600                 605             


Asp Gly Thr Asn Ser Ala Phe Lys Glu Leu Lys Phe Leu Thr Pro Val 
    610                 615                 620                 


Arg Arg Ser Arg Arg Leu Gln Glu Lys Thr Ser Lys Leu Pro Asp Met 
625                 630                 635                 640 


Leu Lys Asp His Tyr Pro Cys Val Ser Ser Leu Glu Gln Leu Thr Glu 
                645                 650                 655     


Leu Gly Arg Glu Thr Asp Ala Phe Val Cys Arg Pro Asn Ala Ala Leu 
            660                 665                 670         


Cys Arg Val Tyr Tyr Glu Ala Asp Thr Thr 
        675                 680         


<210>  1449
<211>  219
<212>  PRT
<213>  homo sapiens

<400>  1449

Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Thr Arg Cys Val Val Thr Phe Arg Ile 
        35                  40                  45              


Phe Gln Thr Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Thr 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Thr 
                85                  90                  95      


Asp Thr Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Thr Pro Leu Thr Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Thr Leu 
                165                 170                 175     


Glu Asp Cys Ala Thr Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Thr Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210>  1450
<211>  846
<212>  PRT
<213>  homo sapiens

<400>  1450

Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Thr Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Thr Gly His Ile Gly Thr Thr Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Thr Leu Gln Ser Thr Ser Thr Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Thr Ser Leu Pro Ser Gln Thr Gln Ser Thr 
                645                 650                 655     


Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln 
        675                 680                 685             


Ser Ala Ala Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr 
                725                 730                 735     


Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ser Gln Thr Leu Ser 
            740                 745                 750         


Val Thr Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Thr 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Thr Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser Thr Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Thr Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210>  1451
<211>  413
<212>  PRT
<213>  homo sapiens

<400>  1451

Met Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu 
        355                 360                 365             


Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu 
    370                 375                 380                 


Glu Asp Glu Ser Ile Ser Leu Ser Pro Thr Lys Pro Asn Arg Arg Val 
385                 390                 395                 400 


Arg Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
                405                 410             


<210>  1452
<211>  417
<212>  PRT
<213>  homo sapiens

<400>  1452

Met Arg Leu Ile Leu Pro Val Gly Leu Ile Ala Thr Thr Leu Ala Ile 
1               5                   10                  15      


Ala Pro Val Arg Phe Asp Arg Glu Lys Val Phe Arg Val Lys Pro Gln 
            20                  25                  30          


Asp Glu Lys Gln Ala Asp Ile Ile Lys Asp Leu Ala Lys Thr Asn Glu 
        35                  40                  45              


Leu Asp Phe Trp Tyr Pro Gly Ala Thr His His Val Ala Ala Asn Met 
    50                  55                  60                  


Met Val Asp Phe Arg Val Ser Glu Lys Glu Ser Gln Ala Ile Gln Ser 
65                  70                  75                  80  


Ala Leu Asp Gln Asn Lys Met His Tyr Glu Ile Leu Ile His Asp Leu 
                85                  90                  95      


Gln Glu Glu Ile Glu Lys Gln Phe Asp Val Lys Glu Asp Ile Pro Gly 
            100                 105                 110         


Arg His Ser Tyr Ala Lys Tyr Asn Asn Trp Glu Lys Ile Val Ala Trp 
        115                 120                 125             


Thr Glu Lys Met Met Asp Lys Tyr Pro Glu Met Val Ser Arg Ile Lys 
    130                 135                 140                 


Ile Gly Ser Thr Val Glu Asp Asn Pro Leu Tyr Val Leu Lys Ile Gly 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Arg Lys Ala Ile Phe Thr Asp Cys Gly Ile His 
                165                 170                 175     


Ala Arg Glu Trp Val Ser Pro Ala Phe Cys Gln Trp Phe Val Tyr Gln 
            180                 185                 190         


Ala Thr Lys Thr Tyr Gly Arg Asn Lys Ile Met Thr Lys Leu Leu Asp 
        195                 200                 205             


Arg Met Asn Phe Tyr Ile Leu Pro Val Phe Asn Val Asp Gly Tyr Ile 
    210                 215                 220                 


Trp Ser Trp Thr Lys Asn Arg Met Trp Arg Lys Asn Arg Ser Lys Asn 
225                 230                 235                 240 


Gln Asn Ser Lys Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala 
                245                 250                 255     


Ser Trp Asn Ser Ile Pro Asn Thr Asn Asp Pro Cys Ala Asp Asn Tyr 
            260                 265                 270         


Arg Gly Ser Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Val Thr Asn 
        275                 280                 285             


Phe Ile Arg Ser His Leu Asn Glu Ile Lys Val Tyr Ile Thr Phe His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Leu Leu Phe Pro Tyr Gly Tyr Thr Ser Lys Leu 
305                 310                 315                 320 


Pro Pro Asn His Glu Asp Leu Ala Lys Val Ala Lys Ile Gly Thr Asp 
                325                 330                 335     


Val Leu Ser Thr Arg Tyr Glu Thr Arg Tyr Ile Tyr Gly Pro Ile Glu 
            340                 345                 350         


Ser Thr Ile Tyr Pro Ile Ser Gly Ser Ser Leu Asp Trp Ala Tyr Asp 
        355                 360                 365             


Leu Gly Ile Lys His Thr Phe Ala Phe Glu Leu Arg Asp Lys Gly Lys 
    370                 375                 380                 


Phe Gly Phe Leu Leu Pro Glu Ser Arg Ile Lys Pro Thr Cys Arg Glu 
385                 390                 395                 400 


Thr Met Leu Ala Val Lys Phe Ile Ala Lys Tyr Ile Leu Lys His Thr 
                405                 410                 415     


Ser 
    


<210>  1453
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  1453

Met Thr Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Thr Glu Ala Glu Asn Gln Gln Met Thr Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Thr Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Thr Ser 
        35                  40                  45              


Ser Ala Pro Thr Val Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Thr Val Gln Ile Ser Thr Ile Ala Glu Ser Glu Asp 
                85                  90                  95      


Ser Gln Glu Ser Val Asp Ser Val Thr Asp Ser Gln Lys Arg Arg Glu 
            100                 105                 110         


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser 
        115                 120                 125             


Ser Asp Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu 
    130                 135                 140                 


Glu Thr Ser Ala Pro Ala Ile Thr Thr Val Thr Val Pro Thr Pro Ile 
145                 150                 155                 160 


Tyr Gln Thr Ser Ser Gly Gln Tyr Ile Ala Ile Thr Gln Gly Gly Ala 
                165                 170                 175     


Ile Gln Leu Ala Asn Asn Gly Thr Asp Gly Val Gln Gly Leu Gln Thr 
            180                 185                 190         


Leu Thr Met Thr Asn Ala Ala Ala Thr Gln Pro Gly Thr Thr Ile Leu 
        195                 200                 205             


Gln Tyr Ala Gln Thr Thr Asp Gly Gln Gln Ile Leu Val Pro Ser Asn 
    210                 215                 220                 


Gln Val Val Val Gln Ala Ala Ser Gly Asp Val Gln Thr Tyr Gln Ile 
225                 230                 235                 240 


Arg Thr Ala Pro Thr Ser Thr Ile Ala Pro Gly Val Val Met Ala Ser 
                245                 250                 255     


Ser Pro Ala Leu Pro Thr Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg 
            260                 265                 270         


Glu Val Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg 
        275                 280                 285             


Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu 
    290                 295                 300                 


Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp 
305                 310                 315                 320 


Leu Tyr Cys His Lys Ser Asp 
                325         


<210>  1454
<211>  520
<212>  PRT
<213>  homo sapiens

<400>  1454

Met Pro Gln Leu Ser Leu Ser Ser Leu Gly Leu Trp Pro Met Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Cys Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Cys Cys Trp Trp Val Gly Pro Trp His 
                85                  90                  95      


Ala Ile Val Arg Ile Phe His Pro Thr Tyr Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Val Pro Lys Asp Lys Val Phe Tyr Ser Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Glu Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Thr Lys Arg His Gln Gln Ile Leu 
225                 230                 235                 240 


Leu Tyr Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Ala Val Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Lys 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Gly Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  1455
<211>  337
<212>  PRT
<213>  homo sapiens

<400>  1455

Met Asp Glu Thr Gly Asn Leu Thr Val Ser Ser Ala Thr Cys His Asp 
1               5                   10                  15      


Thr Ile Asp Asp Phe Arg Asn Gln Val Tyr Ser Thr Leu Tyr Ser Met 
            20                  25                  30          


Ile Ser Val Val Gly Phe Phe Gly Asn Gly Phe Val Leu Tyr Val Leu 
        35                  40                  45              


Ile Lys Thr Tyr His Lys Lys Ser Ala Phe Gln Val Tyr Met Ile Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Leu Cys Val Cys Thr Leu Pro Leu Arg Val 
65                  70                  75                  80  


Val Tyr Tyr Val His Lys Gly Ile Trp Leu Phe Gly Asp Phe Leu Cys 
                85                  90                  95      


Arg Leu Ser Thr Tyr Ala Leu Tyr Val Asn Leu Tyr Cys Ser Ile Phe 
            100                 105                 110         


Phe Met Thr Ala Met Ser Phe Phe Arg Cys Ile Ala Ile Val Phe Pro 
        115                 120                 125             


Val Gln Asn Ile Asn Leu Val Thr Gln Lys Lys Ala Arg Phe Val Cys 
    130                 135                 140                 


Val Gly Ile Trp Ile Phe Val Ile Leu Thr Ser Ser Pro Phe Leu Met 
145                 150                 155                 160 


Ala Lys Pro Gln Lys Asp Glu Lys Asn Asn Thr Lys Cys Phe Glu Pro 
                165                 170                 175     


Pro Gln Asp Asn Gln Thr Lys Asn His Val Leu Val Leu His Tyr Val 
            180                 185                 190         


Ser Leu Phe Val Gly Phe Ile Ile Pro Phe Val Ile Ile Ile Val Cys 
        195                 200                 205             


Tyr Thr Met Ile Ile Leu Thr Leu Leu Lys Lys Ser Met Lys Lys Asn 
    210                 215                 220                 


Leu Ser Ser His Lys Lys Ala Ile Gly Met Ile Met Val Val Thr Ala 
225                 230                 235                 240 


Ala Phe Leu Val Ser Phe Met Pro Tyr His Ile Gln Arg Thr Ile His 
                245                 250                 255     


Leu His Phe Leu His Asn Glu Thr Lys Pro Cys Asp Ser Val Leu Arg 
            260                 265                 270         


Met Gln Lys Ser Val Val Ile Thr Leu Ser Leu Ala Ala Ser Asn Cys 
        275                 280                 285             


Cys Phe Asp Pro Leu Leu Tyr Phe Phe Ser Gly Gly Asn Phe Arg Lys 
    290                 295                 300                 


Arg Leu Ser Thr Phe Arg Lys His Ser Leu Ser Ser Val Thr Tyr Val 
305                 310                 315                 320 


Pro Arg Lys Lys Ala Ser Leu Pro Glu Lys Gly Glu Glu Ile Cys Lys 
                325                 330                 335     


Val 
    


<210>  1456
<211>  1101
<212>  PRT
<213>  homo sapiens

<400>  1456

Met Glu Gln Pro Gly Ala Ala Ala Ser Gly Ala Gly Gly Gly Ser Glu 
1               5                   10                  15      


Glu Pro Gly Gly Gly Arg Ser Asn Lys Arg Ser Ala Gly Asn Arg Ala 
            20                  25                  30          


Ala Asn Glu Glu Glu Thr Lys Asn Lys Pro Lys Leu Asn Ile Gln Ile 
        35                  40                  45              


Lys Thr Leu Ala Asp Asp Val Arg Asp Arg Ile Thr Ser Phe Arg Lys 
    50                  55                  60                  


Ser Thr Val Lys Lys Glu Lys Pro Leu Ile Gln His Pro Ile Asp Ser 
65                  70                  75                  80  


Gln Val Ala Met Ser Glu Phe Pro Ala Ala Gln Pro Leu Tyr Asp Glu 
                85                  90                  95      


Arg Ser Leu Asn Leu Ser Glu Lys Glu Val Leu Asp Leu Phe Glu Lys 
            100                 105                 110         


Met Met Glu Asp Met Asn Leu Asn Glu Glu Lys Lys Ala Pro Leu Arg 
        115                 120                 125             


Asn Lys Asp Phe Thr Thr Lys Arg Glu Met Val Val Gln Tyr Ile Ser 
    130                 135                 140                 


Ala Thr Ala Lys Ser Gly Gly Leu Lys Asn Ser Lys His Glu Cys Thr 
145                 150                 155                 160 


Leu Ser Ser Gln Glu Tyr Val His Glu Leu Arg Ser Gly Ile Ser Asp 
                165                 170                 175     


Glu Lys Leu Leu Asn Cys Leu Glu Ser Leu Arg Val Ser Leu Thr Ser 
            180                 185                 190         


Asn Pro Val Ser Trp Val Asn Asn Phe Gly His Glu Gly Leu Gly Leu 
        195                 200                 205             


Leu Leu Asp Glu Leu Glu Lys Leu Leu Asp Lys Lys Gln Gln Glu Asn 
    210                 215                 220                 


Ile Asp Lys Lys Asn Gln Tyr Lys Leu Ile Gln Cys Leu Lys Ala Phe 
225                 230                 235                 240 


Met Asn Asn Lys Phe Gly Leu Gln Arg Ile Leu Gly Asp Glu Arg Ser 
                245                 250                 255     


Leu Leu Leu Leu Ala Arg Ala Ile Asp Pro Lys Gln Pro Asn Met Met 
            260                 265                 270         


Thr Glu Ile Val Lys Ile Leu Ser Ala Ile Cys Ile Val Gly Glu Glu 
        275                 280                 285             


Asn Ile Leu Asp Lys Leu Leu Gly Ala Ile Thr Thr Ala Ala Glu Arg 
    290                 295                 300                 


Asn Asn Arg Glu Arg Phe Ser Pro Ile Val Glu Gly Leu Glu Asn Gln 
305                 310                 315                 320 


Glu Ala Leu Gln Leu Gln Val Ala Cys Met Gln Phe Ile Asn Ala Leu 
                325                 330                 335     


Val Thr Ser Pro Tyr Glu Leu Asp Phe Arg Ile His Leu Arg Asn Glu 
            340                 345                 350         


Phe Leu Arg Ser Gly Leu Lys Thr Met Leu Pro Asp Leu Lys Glu Lys 
        355                 360                 365             


Glu Asn Asp Glu Leu Asp Ile Gln Leu Lys Val Phe Asp Glu Asn Lys 
    370                 375                 380                 


Glu Asp Asp Leu Thr Glu Leu Ser His Arg Leu Asn Asp Ile Arg Ala 
385                 390                 395                 400 


Glu Met Asp Asp Met Asn Glu Val Tyr His Leu Leu Tyr Asn Met Leu 
                405                 410                 415     


Lys Asp Thr Ala Ala Glu Asn Tyr Phe Leu Ser Ile Leu Gln His Phe 
            420                 425                 430         


Leu Leu Ile Arg Asn Asp Tyr Tyr Ile Arg Pro Gln Tyr Tyr Lys Ile 
        435                 440                 445             


Ile Glu Glu Cys Val Ser Gln Ile Val Leu His Cys Ser Gly Met Asp 
    450                 455                 460                 


Pro Asp Phe Lys Tyr Arg Gln Arg Leu Asp Ile Asp Leu Thr His Leu 
465                 470                 475                 480 


Ile Asp Ser Cys Val Asn Lys Ala Lys Val Glu Glu Ser Glu Gln Lys 
                485                 490                 495     


Ala Ala Glu Phe Ser Lys Lys Phe Asp Glu Glu Phe Thr Ala Arg Gln 
            500                 505                 510         


Glu Ala Gln Ala Glu Leu Gln Lys Arg Asp Glu Lys Ile Lys Glu Leu 
        515                 520                 525             


Glu Ala Glu Ile Gln Gln Leu Arg Thr Gln Ala Gln Val Leu Ser Ser 
    530                 535                 540                 


Ser Ser Gly Ile Pro Gly Pro Pro Ala Ala Pro Pro Leu Pro Gly Val 
545                 550                 555                 560 


Gly Pro Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Gly Gly Ala Pro 
                565                 570                 575     


Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Met Gly Ile Pro Pro 
            580                 585                 590         


Pro Pro Pro Pro Pro Leu Leu Phe Gly Gly Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Leu Gly Gly Val Pro Pro Pro Pro Gly Ile Ser Leu Asn Leu Pro Tyr 
    610                 615                 620                 


Gly Met Lys Gln Lys Lys Met Tyr Lys Pro Glu Val Ser Met Lys Arg 
625                 630                 635                 640 


Ile Asn Trp Ser Lys Ile Glu Pro Thr Glu Leu Ser Glu Asn Cys Phe 
                645                 650                 655     


Trp Leu Arg Val Lys Glu Asp Lys Phe Glu Asn Pro Asp Leu Phe Ala 
            660                 665                 670         


Lys Leu Ala Leu Asn Phe Ala Thr Gln Ile Lys Val Gln Lys Asn Ala 
        675                 680                 685             


Glu Ala Leu Glu Glu Lys Lys Thr Gly Pro Thr Lys Lys Lys Val Lys 
    690                 695                 700                 


Glu Leu Arg Ile Leu Asp Pro Lys Thr Ala Gln Asn Leu Ser Ile Phe 
705                 710                 715                 720 


Leu Gly Ser Tyr Arg Met Pro Tyr Glu Asp Ile Arg Asn Val Ile Leu 
                725                 730                 735     


Glu Val Asn Glu Asp Met Leu Ser Glu Ala Leu Ile Gln Asn Leu Val 
            740                 745                 750         


Lys His Leu Pro Glu Gln Lys Ile Leu Asn Glu Leu Ala Glu Leu Lys 
        755                 760                 765             


Asn Glu Tyr Asp Asp Leu Cys Glu Pro Glu Gln Phe Gly Val Val Met 
    770                 775                 780                 


Ser Ser Val Lys Met Leu Gln Pro Arg Leu Ser Ser Ile Leu Phe Lys 
785                 790                 795                 800 


Leu Thr Phe Glu Glu His Ile Asn Asn Ile Lys Pro Ser Ile Ile Ala 
                805                 810                 815     


Val Thr Leu Ala Cys Glu Glu Leu Lys Lys Ser Glu Ser Phe Asn Arg 
            820                 825                 830         


Leu Leu Glu Leu Val Leu Leu Val Gly Asn Tyr Met Asn Ser Gly Ser 
        835                 840                 845             


Arg Asn Ala Gln Ser Leu Gly Phe Lys Ile Asn Phe Leu Cys Lys Ile 
    850                 855                 860                 


Arg Asp Thr Lys Ser Ala Asp Gln Lys Thr Thr Leu Leu His Phe Ile 
865                 870                 875                 880 


Ala Asp Ile Cys Glu Glu Lys Tyr Arg Asp Ile Leu Lys Phe Pro Glu 
                885                 890                 895     


Glu Leu Glu His Val Glu Ser Ala Ser Lys Val Ser Ala Gln Ile Leu 
            900                 905                 910         


Lys Ser Asn Leu Ala Ser Met Glu Gln Gln Ile Val His Leu Glu Arg 
        915                 920                 925             


Asp Ile Lys Lys Phe Pro Gln Ala Glu Asn Gln His Asp Lys Phe Val 
    930                 935                 940                 


Glu Lys Met Thr Ser Phe Thr Lys Thr Ala Arg Glu Gln Tyr Glu Lys 
945                 950                 955                 960 


Leu Ser Thr Met His Asn Asn Met Met Lys Leu Tyr Glu Asn Leu Gly 
                965                 970                 975     


Glu Tyr Phe Ile Phe Asp Ser Lys Thr Val Ser Ile Glu Glu Phe Phe 
            980                 985                 990         


Gly Asp Leu Asn Asn Phe Arg Thr  Leu Phe Leu Glu Ala  Val Arg Glu 
        995                 1000                 1005             


Asn Asn  Lys Arg Arg Glu Met  Glu Glu Lys Thr Arg  Arg Ala Lys 
    1010                 1015                 1020             


Leu Ala  Lys Glu Lys Ala Glu  Gln Glu Lys Leu Glu  Arg Gln Lys 
    1025                 1030                 1035             


Lys Lys  Lys Gln Leu Ile Asp  Ile Asn Lys Glu Gly  Asp Glu Thr 
    1040                 1045                 1050             


Gly Val  Met Asp Asn Leu Leu  Glu Ala Leu Gln Ser  Gly Ala Ala 
    1055                 1060                 1065             


Phe Arg  Asp Arg Arg Lys Arg  Ile Pro Arg Asn Pro  Asp Asn Arg 
    1070                 1075                 1080             


Arg Val  Pro Leu Glu Arg Ser  Arg Ser Arg His Asn  Gly Ala Ile 
    1085                 1090                 1095             


Ser Ser  Lys 
    1100     


<210>  1457
<211>  240
<212>  PRT
<213>  homo sapiens

<400>  1457

Met Ala Thr Asp Glu Leu Ala Thr Lys Leu Ser Arg Arg Leu Gln Met 
1               5                   10                  15      


Glu Gly Glu Gly Gly Gly Glu Thr Pro Glu Gln Pro Gly Leu Asn Gly 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Gly Ala Pro Asp Glu Ala Ala Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Asp Cys Glu Leu Ser Ala Lys Leu Leu Arg Arg Ala Asp 
    50                  55                  60                  


Leu Asn Gln Gly Ile Gly Glu Pro Gln Ser Pro Ser Arg Arg Val Phe 
65                  70                  75                  80  


Asn Pro Tyr Thr Glu Phe Lys Glu Phe Ser Arg Lys Gln Ile Lys Asp 
                85                  90                  95      


Met Glu Lys Met Phe Lys Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile 
            100                 105                 110         


Asp Leu Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln 
        115                 120                 125             


Thr His Leu Gly Leu Lys Asn Met Ile Lys Glu Val Asp Glu Asp Phe 
    130                 135                 140                 


Asp Ser Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe Arg Lys Ala 
145                 150                 155                 160 


Ala Ala Gly Glu Leu Gln Glu Asp Ser Gly Leu Cys Val Leu Ala Arg 
                165                 170                 175     


Leu Ser Glu Ile Asp Val Ser Ser Glu Gly Val Lys Gly Ala Lys Ser 
            180                 185                 190         


Phe Phe Glu Ala Lys Val Gln Ala Ile Asn Val Ser Ser Arg Phe Glu 
        195                 200                 205             


Glu Glu Ile Lys Ala Glu Gln Glu Glu Arg Lys Lys Gln Ala Glu Glu 
    210                 215                 220                 


Met Lys Gln Arg Lys Ala Ala Phe Lys Glu Leu Gln Ser Thr Phe Lys 
225                 230                 235                 240 


<210>  1458
<211>  1120
<212>  PRT
<213>  homo sapiens

<400>  1458

Met Val Leu Asn Ser Leu Asp Lys Met Ile Gln Leu Gln Lys Asn Thr 
1               5                   10                  15      


Ala Asn Ile Arg Asn Ile Cys Val Leu Ala His Val Asp His Gly Lys 
            20                  25                  30          


Thr Thr Leu Ala Asp Cys Leu Ile Ser Ser Asn Gly Ile Ile Ser Ser 
        35                  40                  45              


Arg Leu Ala Gly Lys Leu Arg Tyr Met Asp Ser Arg Glu Asp Glu Gln 
    50                  55                  60                  


Ile Arg Gly Ile Thr Met Lys Ser Ser Ala Ile Ser Leu His Tyr Ala 
65                  70                  75                  80  


Thr Gly Asn Glu Glu Tyr Leu Ile Asn Leu Ile Asp Ser Pro Gly His 
                85                  90                  95      


Val Asp Phe Ser Ser Glu Val Ser Thr Ala Val Arg Ile Cys Asp Gly 
            100                 105                 110         


Cys Ile Ile Val Val Asp Ala Val Glu Gly Val Cys Pro Gln Thr Gln 
        115                 120                 125             


Ala Val Leu Arg Gln Ala Trp Leu Glu Asn Ile Arg Pro Val Leu Val 
    130                 135                 140                 


Ile Asn Lys Ile Asp Arg Leu Ile Val Glu Leu Lys Phe Thr Pro Gln 
145                 150                 155                 160 


Glu Ala Tyr Ser His Leu Lys Asn Ile Leu Glu Gln Ile Asn Ala Leu 
                165                 170                 175     


Thr Gly Thr Leu Phe Thr Ser Lys Val Leu Glu Glu Arg Ala Glu Arg 
            180                 185                 190         


Glu Thr Glu Ser Gln Val Asn Pro Asn Ser Glu Gln Gly Glu Gln Val 
        195                 200                 205             


Tyr Asp Trp Ser Thr Gly Leu Glu Asp Thr Asp Asp Ser His Leu Tyr 
    210                 215                 220                 


Phe Ser Pro Glu Gln Gly Asn Val Val Phe Thr Ser Ala Ile Asp Gly 
225                 230                 235                 240 


Trp Gly Phe Gly Ile Glu His Phe Ala Arg Ile Tyr Ser Gln Lys Ile 
                245                 250                 255     


Gly Ile Lys Lys Glu Val Leu Met Lys Thr Leu Trp Gly Asp Tyr Tyr 
            260                 265                 270         


Ile Asn Met Lys Ala Lys Lys Ile Met Lys Gly Asp Gln Ala Lys Gly 
        275                 280                 285             


Lys Lys Pro Leu Phe Val Gln Leu Ile Leu Glu Asn Ile Trp Ser Leu 
    290                 295                 300                 


Tyr Asp Ala Val Leu Lys Lys Asp Lys Asp Lys Ile Asp Lys Ile Val 
305                 310                 315                 320 


Thr Ser Leu Gly Leu Lys Ile Gly Ala Arg Glu Ala Arg His Ser Asp 
                325                 330                 335     


Pro Lys Val Gln Ile Asn Ala Ile Cys Ser Gln Trp Leu Pro Ile Ser 
            340                 345                 350         


His Ala Val Leu Ala Met Val Cys Gln Lys Leu Pro Ser Pro Leu Asp 
        355                 360                 365             


Ile Thr Ala Glu Arg Val Glu Arg Leu Met Cys Thr Gly Ser Gln Thr 
    370                 375                 380                 


Phe Asp Ser Phe Pro Pro Glu Thr Gln Ala Leu Lys Ala Ala Phe Met 
385                 390                 395                 400 


Lys Cys Gly Ser Glu Asp Thr Ala Pro Val Ile Ile Phe Val Ser Lys 
                405                 410                 415     


Met Phe Ala Val Asp Ala Lys Ala Leu Pro Gln Asn Lys Pro Arg Pro 
            420                 425                 430         


Leu Thr Gln Glu Glu Ile Ala Gln Arg Arg Glu Arg Ala Arg Gln Arg 
        435                 440                 445             


His Ala Glu Lys Leu Ala Ala Ala Gln Gly Gln Ala Pro Leu Glu Pro 
    450                 455                 460                 


Thr Gln Asp Gly Ser Ala Ile Glu Thr Cys Pro Lys Gly Glu Glu Pro 
465                 470                 475                 480 


Arg Gly Asp Glu Gln Gln Val Glu Ser Met Thr Pro Lys Pro Val Leu 
                485                 490                 495     


Gln Glu Glu Asn Asn Gln Glu Ser Phe Ile Ala Phe Ala Arg Val Phe 
            500                 505                 510         


Ser Gly Val Ala Arg Arg Gly Lys Lys Ile Phe Val Leu Gly Pro Lys 
        515                 520                 525             


Tyr Ser Pro Leu Glu Phe Leu Arg Arg Val Pro Leu Gly Phe Ser Ala 
    530                 535                 540                 


Pro Pro Asp Gly Leu Pro Gln Val Pro His Met Ala Tyr Cys Ala Leu 
545                 550                 555                 560 


Glu Asn Leu Tyr Leu Leu Met Gly Arg Glu Leu Glu Tyr Leu Glu Glu 
                565                 570                 575     


Val Pro Pro Gly Asn Val Leu Gly Ile Gly Gly Leu Gln Asp Phe Val 
            580                 585                 590         


Leu Lys Ser Ala Thr Leu Cys Ser Leu Pro Ser Cys Pro Pro Phe Ile 
        595                 600                 605             


Pro Leu Asn Phe Glu Ala Thr Pro Ile Val Arg Val Ala Val Glu Pro 
    610                 615                 620                 


Lys His Pro Ser Glu Met Pro Gln Leu Val Lys Gly Met Lys Leu Leu 
625                 630                 635                 640 


Asn Gln Ala Asp Pro Cys Val Gln Ile Leu Ile Gln Glu Thr Gly Glu 
                645                 650                 655     


His Val Leu Val Thr Ala Gly Glu Val His Leu Gln Arg Cys Leu Asp 
            660                 665                 670         


Asp Leu Lys Glu Arg Phe Ala Lys Ile His Ile Ser Val Ser Glu Pro 
        675                 680                 685             


Ile Ile Pro Phe Arg Glu Thr Ile Thr Lys Pro Pro Lys Val Asp Met 
    690                 695                 700                 


Val Asn Glu Glu Ile Gly Lys Gln Gln Lys Val Ala Val Ile His Gln 
705                 710                 715                 720 


Met Lys Glu Asp Gln Ser Lys Ile Pro Glu Gly Ile Gln Val Asp Ser 
                725                 730                 735     


Asp Gly Leu Ile Thr Ile Thr Thr Pro Asn Lys Leu Ala Thr Leu Ser 
            740                 745                 750         


Val Arg Ala Met Pro Leu Pro Glu Glu Val Thr Gln Ile Leu Glu Glu 
        755                 760                 765             


Asn Ser Asp Leu Ile Arg Ser Met Glu Gln Leu Thr Ser Ser Leu Asn 
    770                 775                 780                 


Glu Gly Glu Asn Thr His Met Ile His Gln Lys Thr Gln Glu Lys Ile 
785                 790                 795                 800 


Trp Glu Phe Lys Gly Lys Leu Glu Gln His Leu Thr Gly Arg Arg Trp 
                805                 810                 815     


Arg Asn Ile Val Asp Gln Ile Trp Ser Phe Gly Pro Arg Lys Cys Gly 
            820                 825                 830         


Pro Asn Ile Leu Val Asn Lys Ser Glu Asp Phe Gln Asn Ser Val Trp 
        835                 840                 845             


Thr Gly Pro Ala Asp Lys Ala Ser Lys Glu Ala Ser Arg Tyr Arg Asp 
    850                 855                 860                 


Leu Gly Asn Ser Ile Val Ser Gly Phe Gln Leu Ala Thr Leu Ser Gly 
865                 870                 875                 880 


Pro Met Cys Glu Glu Pro Leu Met Gly Val Cys Phe Val Leu Glu Lys 
                885                 890                 895     


Trp Asp Leu Ser Lys Phe Glu Glu Gln Gly Ala Ser Asp Leu Ala Lys 
            900                 905                 910         


Glu Gly Gln Glu Glu Asn Glu Thr Cys Ser Gly Gly Asn Glu Asn Gln 
        915                 920                 925             


Glu Leu Gln Asp Gly Cys Ser Glu Ala Phe Glu Lys Arg Thr Ser Gln 
    930                 935                 940                 


Lys Gly Glu Ser Pro Leu Thr Asp Cys Tyr Gly Pro Phe Ser Gly Gln 
945                 950                 955                 960 


Leu Ile Ala Thr Met Lys Glu Ala Cys Arg Tyr Ala Leu Gln Val Lys 
                965                 970                 975     


Pro Gln Arg Leu Met Ala Ala Met Tyr Thr Cys Asp Ile Met Ala Thr 
            980                 985                 990         


Gly Asp Val Leu Gly Arg Val Tyr  Ala Val Leu Ser Lys  Arg Glu Gly 
        995                 1000                 1005             


Arg Val  Leu Gln Glu Glu Met  Lys Glu Gly Thr Asp  Met Phe Ile 
    1010                 1015                 1020             


Ile Lys  Ala Val Leu Pro Val  Ala Glu Ser Phe Gly  Phe Ala Asp 
    1025                 1030                 1035             


Glu Ile  Arg Lys Arg Thr Ser  Gly Leu Ala Ser Pro  Gln Leu Val 
    1040                 1045                 1050             


Phe Ser  His Trp Glu Ile Ile  Pro Ser Asp Pro Phe  Trp Val Pro 
    1055                 1060                 1065             


Thr Thr  Glu Glu Glu Tyr Leu  His Phe Gly Glu Lys  Ala Asp Ser 
    1070                 1075                 1080             


Glu Asn  Gln Ala Arg Lys Tyr  Met Asn Ala Val Arg  Lys Arg Lys 
    1085                 1090                 1095             


Gly Leu  Tyr Val Glu Glu Lys  Ile Val Glu His Ala  Glu Lys Gln 
    1100                 1105                 1110             


Arg Thr  Leu Ser Lys Asn Lys  
    1115                 1120 


<210>  1459
<211>  1220
<212>  PRT
<213>  homo sapiens

<400>  1459

Met Gly Lys Lys Gln Lys Asn Lys Ser Glu Asp Ser Thr Lys Asp Asp 
1               5                   10                  15      


Ile Asp Leu Asp Ala Leu Ala Ala Glu Ile Glu Gly Ala Gly Ala Ala 
            20                  25                  30          


Lys Glu Gln Glu Pro Gln Lys Ser Lys Gly Lys Lys Lys Lys Glu Lys 
        35                  40                  45              


Lys Lys Gln Asp Phe Asp Glu Asp Asp Ile Leu Lys Glu Leu Glu Glu 
    50                  55                  60                  


Leu Ser Leu Glu Ala Gln Gly Ile Lys Ala Asp Arg Glu Thr Val Ala 
65                  70                  75                  80  


Val Lys Pro Thr Glu Asn Asn Glu Glu Glu Phe Thr Ser Lys Asp Lys 
                85                  90                  95      


Lys Lys Lys Gly Gln Lys Gly Lys Lys Gln Ser Phe Asp Asp Asn Asp 
            100                 105                 110         


Ser Glu Glu Leu Glu Asp Lys Asp Ser Lys Ser Lys Lys Thr Ala Lys 
        115                 120                 125             


Pro Lys Val Glu Met Tyr Ser Gly Ser Asp Asp Asp Asp Asp Phe Asn 
    130                 135                 140                 


Lys Leu Pro Lys Lys Ala Lys Gly Lys Ala Gln Lys Ser Asn Lys Lys 
145                 150                 155                 160 


Trp Asp Gly Ser Glu Glu Asp Glu Asp Asn Ser Lys Lys Ile Lys Glu 
                165                 170                 175     


Arg Ser Arg Ile Asn Ser Ser Gly Glu Ser Gly Asp Glu Ser Asp Glu 
            180                 185                 190         


Phe Leu Gln Ser Arg Lys Gly Gln Lys Lys Asn Gln Lys Asn Lys Pro 
        195                 200                 205             


Gly Pro Asn Ile Glu Ser Gly Asn Glu Asp Asp Asp Ala Ser Phe Lys 
    210                 215                 220                 


Ile Lys Thr Val Ala Gln Lys Lys Ala Glu Lys Lys Glu Arg Glu Arg 
225                 230                 235                 240 


Lys Lys Arg Asp Glu Glu Lys Ala Lys Leu Arg Lys Leu Lys Glu Lys 
                245                 250                 255     


Glu Glu Leu Glu Thr Gly Lys Lys Asp Gln Ser Lys Gln Lys Glu Ser 
            260                 265                 270         


Gln Arg Lys Phe Glu Glu Glu Thr Val Lys Ser Lys Val Thr Val Asp 
        275                 280                 285             


Thr Gly Val Ile Pro Ala Ser Glu Glu Lys Ala Glu Thr Pro Thr Ala 
    290                 295                 300                 


Ala Glu Asp Asp Asn Glu Gly Asp Lys Lys Lys Lys Asp Lys Lys Lys 
305                 310                 315                 320 


Lys Lys Gly Glu Lys Glu Glu Lys Glu Lys Glu Lys Lys Lys Gly Pro 
                325                 330                 335     


Ser Lys Ala Thr Val Lys Ala Met Gln Glu Ala Leu Ala Lys Leu Lys 
            340                 345                 350         


Glu Glu Glu Glu Arg Gln Lys Arg Glu Glu Glu Glu Arg Ile Lys Arg 
        355                 360                 365             


Leu Glu Glu Leu Glu Ala Lys Arg Lys Glu Glu Glu Arg Leu Glu Gln 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Lys Gln Lys Glu Lys Glu Arg Lys Glu Arg 
385                 390                 395                 400 


Leu Lys Lys Glu Gly Lys Leu Leu Thr Lys Ser Gln Arg Glu Ala Arg 
                405                 410                 415     


Ala Arg Ala Glu Ala Thr Leu Lys Leu Leu Gln Ala Gln Gly Val Glu 
            420                 425                 430         


Val Pro Ser Lys Asp Ser Leu Pro Lys Lys Arg Pro Ile Tyr Glu Asp 
        435                 440                 445             


Lys Lys Arg Lys Lys Ile Pro Gln Gln Leu Glu Ser Lys Glu Val Ser 
    450                 455                 460                 


Glu Ser Met Glu Leu Cys Ala Ala Val Glu Val Met Glu Gln Gly Val 
465                 470                 475                 480 


Pro Glu Lys Glu Glu Thr Pro Pro Pro Val Glu Pro Glu Glu Glu Glu 
                485                 490                 495     


Asp Thr Glu Asp Ala Gly Leu Asp Asp Trp Glu Ala Met Ala Ser Asp 
            500                 505                 510         


Glu Glu Thr Glu Lys Val Glu Gly Asn Lys Val His Ile Glu Val Lys 
        515                 520                 525             


Glu Asn Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    530                 535                 540                 


Glu Glu Ser Glu Glu Glu Glu Glu Glu Glu Gly Glu Ser Glu Gly Ser 
545                 550                 555                 560 


Glu Gly Asp Glu Glu Asp Glu Lys Val Ser Asp Glu Lys Asp Ser Gly 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Pro Ser Lys Glu Met Ser Ser Asp Ser Glu 
            580                 585                 590         


Tyr Asp Ser Asp Asp Asp Arg Thr Lys Glu Glu Arg Ala Tyr Asp Lys 
        595                 600                 605             


Ala Lys Arg Arg Ile Glu Lys Arg Arg Leu Glu His Ser Lys Asn Val 
    610                 615                 620                 


Asn Thr Glu Lys Leu Arg Ala Pro Ile Ile Cys Val Leu Gly His Val 
625                 630                 635                 640 


Asp Thr Gly Lys Thr Lys Ile Leu Asp Lys Leu Arg His Thr His Val 
                645                 650                 655     


Gln Asp Gly Glu Ala Gly Gly Ile Thr Gln Gln Ile Gly Ala Thr Asn 
            660                 665                 670         


Val Pro Leu Glu Ala Ile Asn Glu Gln Thr Lys Met Ile Lys Asn Phe 
        675                 680                 685             


Asp Arg Glu Asn Val Arg Ile Pro Gly Met Leu Ile Ile Asp Thr Pro 
    690                 695                 700                 


Gly His Glu Ser Phe Ser Asn Leu Arg Asn Arg Gly Ser Ser Leu Cys 
705                 710                 715                 720 


Asp Ile Ala Ile Leu Val Val Asp Ile Met His Gly Leu Glu Pro Gln 
                725                 730                 735     


Thr Ile Glu Ser Ile Asn Leu Leu Lys Ser Lys Lys Cys Pro Phe Ile 
            740                 745                 750         


Val Ala Leu Asn Lys Ile Asp Arg Leu Tyr Asp Trp Lys Lys Ser Pro 
        755                 760                 765             


Asp Ser Asp Val Ala Ala Thr Leu Lys Lys Gln Lys Lys Asn Thr Lys 
    770                 775                 780                 


Asp Glu Phe Glu Glu Arg Ala Lys Ala Ile Ile Val Glu Phe Ala Gln 
785                 790                 795                 800 


Gln Gly Leu Asn Ala Ala Leu Phe Tyr Glu Asn Lys Asp Pro Arg Thr 
                805                 810                 815     


Phe Val Ser Leu Val Pro Thr Ser Ala His Thr Gly Asp Gly Met Gly 
            820                 825                 830         


Ser Leu Ile Tyr Leu Leu Val Glu Leu Thr Gln Thr Met Leu Ser Lys 
        835                 840                 845             


Arg Leu Ala His Cys Glu Glu Leu Arg Ala Gln Val Met Glu Val Lys 
    850                 855                 860                 


Ala Leu Pro Gly Met Gly Thr Thr Ile Asp Val Ile Leu Ile Asn Gly 
865                 870                 875                 880 


Arg Leu Lys Glu Gly Asp Thr Ile Ile Val Pro Gly Val Glu Gly Pro 
                885                 890                 895     


Ile Val Thr Gln Ile Arg Gly Leu Leu Leu Pro Pro Pro Met Lys Glu 
            900                 905                 910         


Leu Arg Val Lys Asn Gln Tyr Glu Lys His Lys Glu Val Glu Ala Ala 
        915                 920                 925             


Gln Gly Val Lys Ile Leu Gly Lys Asp Leu Glu Lys Thr Leu Ala Gly 
    930                 935                 940                 


Leu Pro Leu Leu Val Ala Tyr Lys Glu Asp Glu Ile Pro Val Leu Lys 
945                 950                 955                 960 


Asp Glu Leu Ile His Glu Leu Lys Gln Thr Leu Asn Ala Ile Lys Leu 
                965                 970                 975     


Glu Glu Lys Gly Val Tyr Val Gln Ala Ser Thr Leu Gly Ser Leu Glu 
            980                 985                 990         


Ala Leu Leu Glu Phe Leu Lys Thr  Ser Glu Val Pro Tyr  Ala Gly Ile 
        995                 1000                 1005             


Asn Ile  Gly Pro Val His Lys  Lys Asp Val Met Lys  Ala Ser Val 
    1010                 1015                 1020             


Met Leu  Glu His Asp Pro Gln  Tyr Ala Val Ile Leu  Ala Phe Asp 
    1025                 1030                 1035             


Val Arg  Ile Glu Arg Asp Ala  Gln Glu Met Ala Asp  Ser Leu Gly 
    1040                 1045                 1050             


Val Arg  Ile Phe Ser Ala Glu  Ile Ile Tyr His Leu  Phe Asp Ala 
    1055                 1060                 1065             


Phe Thr  Lys Tyr Arg Gln Asp  Tyr Lys Lys Gln Lys  Gln Glu Glu 
    1070                 1075                 1080             


Phe Lys  His Ile Ala Val Phe  Pro Cys Lys Ile Lys  Ile Leu Pro 
    1085                 1090                 1095             


Gln Tyr  Ile Phe Asn Ser Arg  Asp Pro Ile Val Met  Gly Val Thr 
    1100                 1105                 1110             


Val Glu  Ala Gly Gln Val Lys  Gln Gly Thr Pro Met  Cys Val Pro 
    1115                 1120                 1125             


Ser Lys  Asn Phe Val Asp Ile  Gly Ile Val Thr Ser  Ile Glu Ile 
    1130                 1135                 1140             


Asn His  Lys Gln Val Asp Val  Ala Lys Lys Gly Gln  Glu Val Cys 
    1145                 1150                 1155             


Val Lys  Ile Glu Pro Ile Pro  Gly Glu Ser Pro Lys  Met Phe Gly 
    1160                 1165                 1170             


Arg His  Phe Glu Ala Thr Asp  Ile Leu Val Ser Lys  Ile Ser Arg 
    1175                 1180                 1185             


Gln Ser  Ile Asp Ala Leu Lys  Asp Trp Phe Arg Asp  Glu Met Gln 
    1190                 1195                 1200             


Lys Ser  Asp Trp Gln Leu Ile  Val Glu Leu Lys Lys  Val Phe Glu 
    1205                 1210                 1215             


Ile Ile  
    1220 


<210>  1460
<211>  443
<212>  PRT
<213>  homo sapiens

<400>  1460

Met Val Arg Gly Arg Ile Ser Arg Leu Ser Val Arg Asp Val Arg Phe 
1               5                   10                  15      


Pro Thr Ser Leu Gly Gly His Gly Ala Asp Ala Met His Thr Asp Pro 
            20                  25                  30          


Asp Tyr Ser Ala Ala Tyr Val Val Ile Glu Thr Asp Ala Glu Asp Gly 
        35                  40                  45              


Ile Lys Gly Cys Gly Ile Thr Phe Thr Leu Gly Lys Gly Thr Glu Val 
    50                  55                  60                  


Val Val Cys Ala Val Asn Ala Leu Ala His His Val Leu Asn Lys Asp 
65                  70                  75                  80  


Leu Lys Asp Ile Val Gly Asp Phe Arg Gly Phe Tyr Arg Gln Leu Thr 
                85                  90                  95      


Ser Asp Gly Gln Leu Arg Trp Ile Gly Pro Glu Lys Gly Val Val His 
            100                 105                 110         


Leu Ala Thr Ala Ala Val Leu Asn Ala Val Trp Asp Leu Trp Ala Lys 
        115                 120                 125             


Gln Glu Gly Lys Pro Val Trp Lys Leu Leu Val Asp Met Asp Pro Arg 
    130                 135                 140                 


Met Leu Val Ser Cys Ile Asp Phe Arg Tyr Ile Thr Asp Val Leu Thr 
145                 150                 155                 160 


Glu Glu Asp Ala Leu Glu Ile Leu Gln Lys Gly Gln Ile Gly Lys Lys 
                165                 170                 175     


Glu Arg Glu Lys Gln Met Leu Ala Gln Gly Tyr Pro Ala Tyr Thr Thr 
            180                 185                 190         


Ser Cys Ala Trp Leu Gly Tyr Ser Asp Asp Thr Leu Lys Gln Leu Cys 
        195                 200                 205             


Ala Gln Ala Leu Lys Asp Gly Trp Thr Arg Phe Lys Val Lys Val Gly 
    210                 215                 220                 


Ala Asp Leu Gln Asp Asp Met Arg Arg Cys Gln Ile Ile Arg Asp Met 
225                 230                 235                 240 


Ile Gly Pro Glu Lys Thr Leu Met Met Asp Ala Asn Gln Arg Trp Asp 
                245                 250                 255     


Val Pro Glu Ala Val Glu Trp Met Ser Lys Leu Ala Lys Phe Lys Pro 
            260                 265                 270         


Leu Trp Ile Glu Glu Pro Thr Ser Pro Asp Asp Ile Leu Gly His Ala 
        275                 280                 285             


Thr Ile Ser Lys Ala Leu Val Pro Leu Gly Ile Gly Ile Ala Thr Gly 
    290                 295                 300                 


Glu Gln Cys His Asn Arg Val Ile Phe Lys Gln Leu Leu Gln Ala Lys 
305                 310                 315                 320 


Ala Leu Gln Phe Leu Gln Ile Asp Ser Cys Arg Leu Gly Ser Val Asn 
                325                 330                 335     


Glu Asn Leu Ser Val Leu Leu Met Ala Lys Lys Phe Glu Ile Pro Val 
            340                 345                 350         


Cys Pro His Ala Gly Gly Val Gly Leu Cys Glu Leu Val Gln His Leu 
        355                 360                 365             


Ile Ile Phe Asp Tyr Ile Ser Val Ser Ala Ser Leu Glu Asn Arg Val 
    370                 375                 380                 


Cys Glu Tyr Val Asp His Leu His Glu His Phe Lys Tyr Pro Val Met 
385                 390                 395                 400 


Ile Gln Arg Ala Ser Tyr Met Pro Pro Lys Asp Pro Gly Tyr Ser Thr 
                405                 410                 415     


Glu Met Lys Glu Glu Ser Val Lys Lys His Gln Tyr Pro Asp Gly Glu 
            420                 425                 430         


Val Trp Lys Lys Leu Leu Pro Ala Gln Glu Asn 
        435                 440             


<210>  1461
<211>  510
<212>  PRT
<213>  homo sapiens

<400>  1461

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  1462
<211>  916
<212>  PRT
<213>  homo sapiens

<400>  1462

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 
        355                 360                 365             


Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 
    370                 375                 380                 


Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 
385                 390                 395                 400 


Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 
                405                 410                 415     


Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 
            420                 425                 430         


Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 
        435                 440                 445             


Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 
    450                 455                 460                 


Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 
                485                 490                 495     


Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 
            500                 505                 510         


Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 
        515                 520                 525             


Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 
    530                 535                 540                 


Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 
545                 550                 555                 560 


Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 
                565                 570                 575     


Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 
            580                 585                 590         


Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 
        595                 600                 605             


Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 
625                 630                 635                 640 


Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 
                645                 650                 655     


Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 
            660                 665                 670         


Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 
        675                 680                 685             


Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 
    690                 695                 700                 


Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 
705                 710                 715                 720 


Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 
                725                 730                 735     


Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 
            740                 745                 750         


Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 
        755                 760                 765             


Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 
    770                 775                 780                 


Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 
785                 790                 795                 800 


Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 
                805                 810                 815     


Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 
            820                 825                 830         


Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 
        835                 840                 845             


Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 
    850                 855                 860                 


Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 
865                 870                 875                 880 


Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 
                885                 890                 895     


Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 
            900                 905                 910         


Lys Gly Lys Lys 
        915     


<210>  1463
<211>  851
<212>  PRT
<213>  homo sapiens

<400>  1463

Met Ser Ser Lys Gln Glu Ile Met Ser Asp Gln Arg Phe Arg Arg Val 
1               5                   10                  15      


Ala Lys Asp Pro Arg Phe Trp Glu Met Pro Glu Lys Asp Arg Lys Val 
            20                  25                  30          


Lys Ile Asp Lys Arg Phe Arg Ala Met Phe His Asp Lys Lys Phe Lys 
        35                  40                  45              


Leu Asn Tyr Ala Val Asp Lys Arg Gly Arg Pro Ile Ser His Ser Thr 
    50                  55                  60                  


Thr Glu Asp Leu Lys Arg Phe Tyr Asp Leu Ser Asp Ser Asp Ser Asn 
65                  70                  75                  80  


Leu Ser Gly Glu Asp Ser Lys Ala Leu Ser Gln Lys Lys Ile Lys Lys 
                85                  90                  95      


Lys Lys Thr Gln Thr Lys Lys Glu Ile Asp Ser Lys Asn Leu Val Glu 
            100                 105                 110         


Lys Lys Lys Glu Thr Lys Lys Ala Asn His Lys Gly Ser Glu Asn Lys 
        115                 120                 125             


Thr Asp Leu Asp Asn Ser Ile Gly Ile Lys Lys Met Lys Thr Ser Cys 
    130                 135                 140                 


Lys Phe Lys Ile Asp Ser Asn Ile Ser Pro Lys Lys Asp Ser Lys Glu 
145                 150                 155                 160 


Phe Thr Gln Lys Asn Lys Lys Glu Lys Lys Asn Ile Val Gln His Thr 
                165                 170                 175     


Thr Asp Ser Ser Leu Glu Glu Lys Gln Arg Thr Leu Asp Ser Gly Thr 
            180                 185                 190         


Ser Glu Ile Val Lys Ser Pro Arg Ile Glu Cys Ser Lys Thr Arg Arg 
        195                 200                 205             


Glu Met Gln Ser Val Val Gln Leu Ile Met Thr Arg Asp Ser Asp Gly 
    210                 215                 220                 


Tyr Glu Asn Ser Thr Asp Gly Glu Met Cys Asp Lys Asp Ala Leu Glu 
225                 230                 235                 240 


Glu Asp Ser Glu Ser Val Ser Glu Ile Gly Ser Asp Glu Glu Ser Glu 
                245                 250                 255     


Asn Glu Ile Thr Ser Val Gly Arg Ala Ser Gly Asp Asp Asp Gly Ser 
            260                 265                 270         


Glu Asp Asp Glu Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Asp Glu 
        275                 280                 285             


Asp Ser Glu Asp Asp Asp Lys Ser Asp Ser Gly Pro Asp Leu Ala Arg 
    290                 295                 300                 


Gly Lys Gly Asn Ile Glu Thr Ser Ser Glu Asp Glu Asp Asp Thr Ala 
305                 310                 315                 320 


Asp Leu Phe Pro Glu Glu Ser Gly Phe Glu His Ala Trp Arg Glu Leu 
                325                 330                 335     


Asp Lys Asp Ala Pro Arg Ala Asp Glu Ile Thr Arg Arg Leu Ala Val 
            340                 345                 350         


Cys Asn Met Asp Trp Asp Arg Leu Lys Ala Lys Asp Leu Leu Ala Leu 
        355                 360                 365             


Phe Asn Ser Phe Lys Pro Lys Gly Gly Val Ile Phe Ser Val Lys Ile 
    370                 375                 380                 


Tyr Pro Ser Glu Phe Gly Lys Glu Arg Met Lys Glu Glu Gln Val Gln 
385                 390                 395                 400 


Gly Pro Val Glu Leu Leu Ser Ile Pro Glu Asp Ala Pro Glu Lys Asp 
                405                 410                 415     


Trp Thr Ser Arg Glu Lys Leu Arg Asp Tyr Gln Phe Lys Arg Leu Lys 
            420                 425                 430         


Tyr Tyr Tyr Ala Val Val Asp Cys Asp Ser Pro Glu Thr Ala Ser Lys 
        435                 440                 445             


Ile Tyr Glu Asp Cys Asp Gly Leu Glu Phe Glu Ser Ser Cys Ser Phe 
    450                 455                 460                 


Ile Asp Leu Arg Phe Ile Pro Asp Asp Ile Thr Phe Asp Asp Glu Pro 
465                 470                 475                 480 


Lys Asp Val Ala Ser Glu Val Asn Leu Thr Ala Tyr Lys Pro Lys Tyr 
                485                 490                 495     


Phe Thr Ser Ala Ala Met Gly Thr Ser Thr Val Glu Ile Thr Trp Asp 
            500                 505                 510         


Glu Thr Asp His Glu Arg Ile Thr Met Leu Asn Arg Lys Phe Lys Lys 
        515                 520                 525             


Glu Glu Leu Leu Asp Met Asp Phe Gln Ala Tyr Leu Ala Ser Ser Ser 
    530                 535                 540                 


Glu Asp Glu Glu Glu Ile Glu Glu Glu Leu Gln Gly Asp Asp Gly Val 
545                 550                 555                 560 


Asn Val Glu Glu Asp Gly Lys Thr Lys Lys Ser Gln Lys Asp Asp Glu 
                565                 570                 575     


Glu Gln Ile Ala Lys Tyr Arg Gln Leu Leu Gln Val Ile Gln Glu Lys 
            580                 585                 590         


Glu Lys Lys Gly Lys Glu Asn Asp Met Glu Met Glu Ile Lys Trp Val 
        595                 600                 605             


Pro Gly Leu Lys Glu Ser Ala Glu Glu Met Val Lys Asn Lys Leu Glu 
    610                 615                 620                 


Gly Lys Asp Lys Leu Thr Pro Trp Glu Gln Phe Leu Glu Lys Lys Lys 
625                 630                 635                 640 


Glu Lys Lys Arg Leu Lys Arg Lys Gln Lys Ala Leu Ala Glu Glu Ala 
                645                 650                 655     


Ser Glu Glu Glu Leu Pro Ser Asp Val Asp Leu Asn Asp Pro Tyr Phe 
            660                 665                 670         


Ala Glu Glu Val Lys Gln Ile Gly Ile Asn Lys Lys Ser Val Lys Ser 
        675                 680                 685             


Ala Lys Asp Gly Thr Ser Pro Glu Glu Glu Ile Glu Ile Glu Arg Gln 
    690                 695                 700                 


Lys Ala Glu Met Ala Leu Leu Met Met Asp Glu Asp Glu Asp Ser Lys 
705                 710                 715                 720 


Lys His Phe Asn Tyr Asn Lys Ile Val Glu His Gln Asn Leu Ser Lys 
                725                 730                 735     


Lys Lys Lys Lys Gln Leu Met Lys Lys Lys Glu Leu Ile Glu Asp Asp 
            740                 745                 750         


Phe Glu Val Asn Val Asn Asp Ala Arg Phe Gln Ala Met Tyr Thr Ser 
        755                 760                 765             


His Leu Phe Asn Leu Asp Pro Ser Asp Pro Asn Phe Lys Lys Thr Lys 
    770                 775                 780                 


Ala Met Glu Lys Ile Leu Glu Glu Lys Ala Arg Gln Arg Glu Arg Lys 
785                 790                 795                 800 


Glu Gln Glu Leu Thr Gln Ala Ile Lys Lys Lys Glu Ser Glu Ile Glu 
                805                 810                 815     


Lys Glu Ser Gln Arg Lys Ser Ile Asp Pro Ala Leu Ser Met Leu Ile 
            820                 825                 830         


Lys Ser Ile Lys Thr Lys Thr Glu Gln Phe Gln Ala Arg Lys Lys Gln 
        835                 840                 845             


Lys Val Lys 
    850     


<210>  1464
<211>  653
<212>  PRT
<213>  homo sapiens

<400>  1464

Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Arg Asp 
            260                 265                 270         


Asp Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val Ser Ala 
        275                 280                 285             


Phe Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp Ile Ile 
    290                 295                 300                 


Pro Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln Asp Ala 
305                 310                 315                 320 


Leu Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala Ala Arg 
                325                 330                 335     


Lys Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val Phe Pro 
            340                 345                 350         


Ile Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln Val Leu 
        355                 360                 365             


Gln Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu Ile Thr 
    370                 375                 380                 


Ser Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala Asp Asn 
385                 390                 395                 400 


Ile Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp Gly Thr 
                405                 410                 415     


Val His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln Leu Leu 
            420                 425                 430         


Asp Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu Thr Ser 
        435                 440                 445             


Ser Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu Leu Ser 
    450                 455                 460                 


Thr Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His 
                485                 490                 495     


Asn Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile 
            500                 505                 510         


Gln Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu 
        515                 520                 525             


His Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val 
    530                 535                 540                 


Thr Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val 
545                 550                 555                 560 


Lys Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly 
                565                 570                 575     


Phe Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala 
            580                 585                 590         


Ile Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr 
        595                 600                 605             


Ile Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val 
    610                 615                 620                 


Pro Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln 
625                 630                 635                 640 


Val Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
                645                 650             


<210>  1465
<211>  919
<212>  PRT
<213>  homo sapiens

<400>  1465

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


<210>  1466
<211>  710
<212>  PRT
<213>  homo sapiens

<400>  1466

Met Leu Thr Thr Leu Lys Pro Phe Gly Ser Val Ser Val Glu Ser Lys 
1               5                   10                  15      


Met Asn Asn Lys Ala Gly Ser Phe Phe Trp Asn Leu Arg Gln Phe Ser 
            20                  25                  30          


Thr Leu Val Ser Thr Ser Arg Thr Met Arg Leu Cys Cys Leu Gly Leu 
        35                  40                  45              


Cys Lys Pro Lys Ile Val His Ser Asn Trp Asn Ile Leu Asn Asn Phe 
    50                  55                  60                  


His Asn Arg Met Gln Ser Thr Asp Ile Ile Arg Tyr Leu Phe Gln Asp 
65                  70                  75                  80  


Ala Phe Ile Phe Lys Ser Asp Val Gly Phe Gln Thr Lys Gly Ile Ser 
                85                  90                  95      


Thr Leu Thr Ala Leu Arg Ile Glu Arg Leu Leu Tyr Ala Lys Arg Leu 
            100                 105                 110         


Phe Phe Asp Ser Lys Gln Ser Leu Val Pro Val Asp Lys Ser Asp Asp 
        115                 120                 125             


Glu Leu Lys Lys Val Asn Leu Asn His Glu Val Ser Asn Glu Asp Val 
    130                 135                 140                 


Leu Thr Lys Glu Thr Lys Pro Asn Arg Ile Ser Ser Arg Lys Leu Ser 
145                 150                 155                 160 


Glu Glu Cys Asn Ser Leu Ser Asp Val Leu Asp Ala Phe Ser Lys Ala 
                165                 170                 175     


Pro Thr Phe Pro Ser Ser Asn Tyr Phe Thr Ala Met Trp Thr Ile Ala 
            180                 185                 190         


Lys Arg Leu Ser Asp Asp Gln Lys Arg Phe Glu Lys Arg Leu Met Phe 
        195                 200                 205             


Ser His Pro Ala Phe Asn Gln Leu Cys Glu His Met Met Arg Glu Ala 
    210                 215                 220                 


Lys Ile Met Gln Tyr Lys Tyr Leu Leu Phe Ser Leu His Ala Ile Val 
225                 230                 235                 240 


Lys Leu Gly Ile Pro Gln Asn Thr Ile Leu Val Gln Thr Leu Leu Arg 
                245                 250                 255     


Val Thr Gln Glu Arg Ile Asn Glu Cys Asp Glu Ile Cys Leu Ser Val 
            260                 265                 270         


Leu Ser Thr Val Leu Glu Ala Met Glu Pro Cys Lys Asn Val His Val 
        275                 280                 285             


Leu Arg Thr Gly Phe Arg Ile Leu Val Asp Gln Gln Val Trp Lys Ile 
    290                 295                 300                 


Glu Asp Val Phe Thr Leu Gln Val Val Met Lys Cys Ile Gly Lys Asp 
305                 310                 315                 320 


Ala Pro Ile Ala Leu Lys Arg Lys Leu Glu Met Lys Ala Leu Arg Glu 
                325                 330                 335     


Leu Asp Arg Phe Ser Val Leu Asn Ser Gln His Met Phe Glu Val Leu 
            340                 345                 350         


Ala Ala Met Asn His Arg Ser Leu Ile Leu Leu Asp Glu Cys Ser Lys 
        355                 360                 365             


Val Val Leu Asp Asn Ile His Gly Cys Pro Leu Arg Ile Met Ile Asn 
    370                 375                 380                 


Ile Leu Gln Ser Cys Lys Asp Leu Gln Tyr His Asn Leu Asp Leu Phe 
385                 390                 395                 400 


Lys Gly Leu Ala Asp Tyr Val Ala Ala Thr Phe Asp Ile Trp Lys Phe 
                405                 410                 415     


Arg Lys Val Leu Phe Ile Leu Ile Leu Phe Glu Asn Leu Gly Phe Arg 
            420                 425                 430         


Pro Val Gly Leu Met Asp Leu Phe Met Lys Arg Ile Val Glu Asp Pro 
        435                 440                 445             


Glu Ser Leu Asn Met Lys Asn Ile Leu Ser Ile Leu His Thr Tyr Ser 
    450                 455                 460                 


Ser Leu Asn His Val Tyr Lys Cys Gln Asn Lys Glu Gln Phe Val Glu 
465                 470                 475                 480 


Val Met Ala Ser Ala Leu Thr Gly Tyr Leu His Thr Ile Ser Ser Glu 
                485                 490                 495     


Asn Leu Leu Asp Ala Val Tyr Ser Phe Cys Leu Met Asn Tyr Phe Pro 
            500                 505                 510         


Leu Ala Pro Phe Asn Gln Leu Leu Gln Lys Asp Ile Ile Ser Glu Leu 
        515                 520                 525             


Leu Thr Ser Asp Asp Met Lys Asn Ala Tyr Lys Leu His Thr Leu Asp 
    530                 535                 540                 


Thr Cys Leu Lys Leu Asp Asp Thr Val Tyr Leu Arg Asp Ile Ala Leu 
545                 550                 555                 560 


Ser Leu Pro Gln Leu Pro Arg Glu Leu Pro Ser Ser His Thr Asn Ala 
                565                 570                 575     


Lys Val Ala Glu Val Leu Ser Ser Leu Leu Gly Gly Glu Gly His Phe 
            580                 585                 590         


Ser Lys Asp Val His Leu Pro His Asn Tyr His Ile Asp Phe Glu Ile 
        595                 600                 605             


Arg Met Asp Thr Asn Arg Asn Gln Val Leu Pro Leu Ser Asp Val Asp 
    610                 615                 620                 


Thr Thr Ser Ala Thr Asp Ile Gln Arg Val Ala Val Leu Cys Val Ser 
625                 630                 635                 640 


Arg Ser Ala Tyr Cys Leu Gly Ser Ser His Pro Arg Gly Phe Leu Ala 
                645                 650                 655     


Met Lys Met Arg His Leu Asn Ala Met Gly Phe His Val Ile Leu Val 
            660                 665                 670         


Asn Asn Trp Glu Met Asp Lys Leu Glu Met Glu Asp Ala Val Thr Phe 
        675                 680                 685             


Leu Lys Thr Lys Ile Tyr Ser Val Glu Ala Leu Pro Val Ala Ala Val 
    690                 695                 700                 


Asn Val Gln Ser Thr Gln 
705                 710 


<210>  1467
<211>  198
<212>  PRT
<213>  homo sapiens

<400>  1467

Met Gly Lys Gln Lys Lys Thr Arg Lys Tyr Ala Thr Met Lys Arg Met 
1               5                   10                  15      


Leu Ser Leu Arg Asp Gln Arg Leu Lys Glu Lys Asp Arg Leu Lys Pro 
            20                  25                  30          


Lys Lys Lys Glu Lys Lys Asp Pro Ser Ala Leu Lys Glu Arg Glu Val 
        35                  40                  45              


Pro Gln His Pro Ser Cys Leu Phe Phe Gln Tyr Asn Thr Gln Leu Gly 
    50                  55                  60                  


Pro Pro Tyr His Ile Leu Val Asp Thr Asn Phe Ile Asn Phe Ser Ile 
65                  70                  75                  80  


Lys Ala Lys Leu Asp Leu Val Gln Ser Met Met Asp Cys Leu Tyr Ala 
                85                  90                  95      


Lys Cys Ile Pro Cys Ile Thr Asp Cys Val Met Ala Glu Ile Glu Lys 
            100                 105                 110         


Leu Gly Gln Lys Tyr Arg Val Ala Leu Arg Ile Ala Lys Asp Pro Arg 
        115                 120                 125             


Phe Glu Arg Leu Pro Cys Thr His Lys Gly Thr Tyr Ala Asp Asp Cys 
    130                 135                 140                 


Leu Val Gln Arg Val Thr Gln His Lys Cys Tyr Ile Val Ala Thr Val 
145                 150                 155                 160 


Asp Arg Asp Leu Lys Arg Arg Ile Arg Lys Ile Pro Gly Val Pro Ile 
                165                 170                 175     


Met Tyr Ile Ser Asn His Arg Tyr Asn Ile Glu Arg Met Pro Asp Asp 
            180                 185                 190         


Tyr Gly Ala Pro Arg Phe 
        195             


<210>  1468
<211>  412
<212>  PRT
<213>  homo sapiens

<400>  1468

Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala Gly Asp Trp 
1               5                   10                  15      


Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln Arg Arg Ile 
            20                  25                  30          


Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys Lys Leu Val 
        35                  40                  45              


Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu His His Val 
    50                  55                  60                  


Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu Thr Val Phe 
                85                  90                  95      


Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile Ser Thr Gly 
            100                 105                 110         


His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val Val Glu Leu 
        115                 120                 125             


Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu Pro Leu Ala 
    130                 135                 140                 


Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His Gly Asp Pro 
145                 150                 155                 160 


Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile Arg Pro Gln 
                165                 170                 175     


Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys Leu Gly Phe 
            180                 185                 190         


Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp Lys Val Gly 
        195                 200                 205             


Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val His Val Glu 
    210                 215                 220                 


Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp Lys Lys Arg 
225                 230                 235                 240 


Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu Ala Lys Thr 
                245                 250                 255     


Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile Ser Trp Ser 
            260                 265                 270         


Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg Gly Val Ile 
        275                 280                 285             


Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val Cys Thr Phe 
    290                 295                 300                 


Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln Thr Leu His 
305                 310                 315                 320 


Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile Tyr Tyr Phe 
                325                 330                 335     


Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala His Gln Pro 
            340                 345                 350         


Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile Ile Gly Val 
        355                 360                 365             


Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn Arg Lys Leu 
    370                 375                 380                 


Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu Lys Ile Glu 
385                 390                 395                 400 


Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                405                 410         


<210>  1469
<211>  466
<212>  PRT
<213>  homo sapiens

<400>  1469

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln 
465     


<210>  1470
<211>  638
<212>  PRT
<213>  homo sapiens

<400>  1470

Met Ser Gly Asp Pro Asp Val Leu Glu Tyr Tyr Lys Asn Asp His Ser 
1               5                   10                  15      


Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn Phe Cys Glu Gln Val Asp 
            20                  25                  30          


Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu Gln Asp Ser Phe Val Phe 
        35                  40                  45              


Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr Leu Val Ala Glu Thr Glu 
    50                  55                  60                  


Glu Asp Met Asn Lys Trp Val Gln Ser Ile Cys Gln Ile Cys Gly Phe 
65                  70                  75                  80  


Asn Gln Ala Glu Glu Ser Thr Asp Ser Leu Arg Asn Val Ser Ser Ala 
                85                  90                  95      


Gly His Gly Pro Arg Ser Ser Pro Ala Glu Leu Ser Ser Ser Ser Gln 
            100                 105                 110         


His Leu Leu Arg Glu Arg Lys Ser Ser Ala Pro Ser His Ser Ser Gln 
        115                 120                 125             


Pro Thr Leu Phe Thr Phe Glu Pro Pro Val Ser Asn His Met Gln Pro 
    130                 135                 140                 


Thr Leu Ser Thr Ser Ala Pro Gln Glu Tyr Leu Tyr Leu His Gln Cys 
145                 150                 155                 160 


Ile Ser Arg Arg Ala Glu Asn Ala Arg Ser Ala Ser Phe Ser Gln Gly 
                165                 170                 175     


Thr Arg Ala Ser Phe Leu Met Arg Ser Asp Thr Ala Val Gln Lys Leu 
            180                 185                 190         


Ala Gln Gly Asn Gly His Cys Val Asn Gly Ile Ser Gly Gln Val His 
        195                 200                 205             


Gly Phe Tyr Ser Leu Pro Lys Pro Ser Arg His Asn Thr Glu Phe Arg 
    210                 215                 220                 


Asp Ser Thr Tyr Asp Leu Pro Arg Ser Leu Ala Ser His Gly His Thr 
225                 230                 235                 240 


Lys Gly Ser Leu Thr Gly Ser Glu Thr Asp Asn Glu Asp Val Tyr Thr 
                245                 250                 255     


Phe Lys Thr Pro Ser Asn Thr Leu Cys Arg Glu Phe Gly Asp Leu Leu 
            260                 265                 270         


Val Asp Asn Met Asp Val Pro Ala Thr Pro Leu Ser Ala Tyr Gln Ile 
        275                 280                 285             


Pro Arg Thr Phe Thr Leu Asp Lys Asn His Asn Ala Met Thr Val Ala 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ala Ile Ala Pro Pro Pro Arg Pro Pro Lys Pro 
305                 310                 315                 320 


Ser Gln Ala Glu Thr Pro Arg Trp Gly Ser Pro Gln Gln Arg Pro Pro 
                325                 330                 335     


Ile Ser Glu Asn Ser Arg Ser Val Ala Ala Thr Ile Pro Arg Arg Asn 
            340                 345                 350         


Thr Leu Pro Ala Met Asp Asn Ser Arg Leu His Arg Ala Ser Ser Cys 
        355                 360                 365             


Glu Thr Tyr Glu Tyr Pro Gln Arg Gly Gly Glu Ser Ala Gly Arg Ser 
    370                 375                 380                 


Ala Glu Ser Met Ser Asp Gly Val Gly Ser Phe Leu Pro Gly Lys Met 
385                 390                 395                 400 


Ile Val Gly Arg Ser Asp Ser Thr Asn Ser Glu Asp Asn Tyr Val Pro 
                405                 410                 415     


Met Asn Pro Gly Ser Ser Thr Leu Leu Ala Met Glu Arg Ala Gly Asp 
            420                 425                 430         


Asn Ser Gln Ser Val Tyr Ile Pro Met Ser Pro Gly Ala His His Phe 
        435                 440                 445             


Asp Ser Leu Gly Tyr Pro Ser Thr Thr Leu Pro Val His Arg Gly Pro 
    450                 455                 460                 


Ser Arg Gly Ser Glu Ile Gln Pro Pro Pro Val Asn Arg Asn Leu Lys 
465                 470                 475                 480 


Pro Asp Arg Lys Ala Lys Pro Thr Pro Leu Asp Leu Arg Asn Asn Thr 
                485                 490                 495     


Val Ile Asp Glu Leu Pro Phe Lys Ser Pro Ile Thr Lys Ser Trp Ser 
            500                 505                 510         


Arg Ala Asn His Thr Phe Asn Ser Ser Ser Ser Gln Tyr Cys Arg Pro 
        515                 520                 525             


Ile Ser Thr Gln Ser Ile Thr Ser Thr Asp Ser Gly Asp Ser Glu Glu 
    530                 535                 540                 


Asn Tyr Val Pro Met Gln Asn Pro Val Ser Ala Ser Pro Val Pro Ser 
545                 550                 555                 560 


Gly Thr Asn Ser Pro Ala Pro Lys Lys Ser Thr Gly Ser Val Asp Tyr 
                565                 570                 575     


Leu Ala Leu Asp Phe Gln Pro Ser Ser Pro Ser Pro His Arg Lys Pro 
            580                 585                 590         


Ser Thr Ser Ser Val Thr Ser Asp Glu Lys Val Asp Tyr Val Gln Val 
        595                 600                 605             


Asp Lys Glu Lys Thr Gln Ala Leu Gln Asn Thr Met Gln Glu Trp Thr 
    610                 615                 620                 


Asp Val Arg Gln Ser Ser Glu Pro Ser Lys Gly Ala Lys Leu 
625                 630                 635             


<210>  1471
<211>  300
<212>  PRT
<213>  homo sapiens

<400>  1471

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  1472
<211>  285
<212>  PRT
<213>  homo sapiens

<400>  1472

Met Thr Thr Leu Thr His Arg Ala Arg Arg Thr Glu Ile Ser Lys Asn 
1               5                   10                  15      


Ser Glu Lys Lys Met Glu Ser Glu Glu Asp Ser Asn Trp Glu Lys Ser 
            20                  25                  30          


Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys Asp Ile Arg Leu Thr Leu 
        35                  40                  45              


Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Lys Glu Gly Tyr Thr 
    50                  55                  60                  


Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Gly Ile Leu 
65                  70                  75                  80  


Ile Glu Leu Ala Met Arg Gly Arg Ile Tyr Leu Glu Pro Pro Thr Met 
                85                  90                  95      


Arg Lys Lys Arg Leu Leu Asp Arg Lys Val Leu Leu Lys Ser Asp Ser 
            100                 105                 110         


Pro Thr Gly Asp Val Leu Leu Asp Glu Thr Leu Lys His Ile Lys Ala 
        115                 120                 125             


Thr Glu Pro Thr Glu Thr Val Gln Thr Trp Ile Glu Leu Leu Thr Gly 
    130                 135                 140                 


Glu Thr Trp Asn Pro Phe Lys Leu Gln Tyr Gln Leu Arg Asn Val Arg 
145                 150                 155                 160 


Glu Arg Ile Ala Lys Asn Leu Val Glu Lys Gly Ile Leu Thr Thr Glu 
                165                 170                 175     


Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Val Thr Asn 
            180                 185                 190         


Thr Thr Glu Lys Gln Arg Leu Val Lys Lys Leu Gln Asp Ser Val Leu 
        195                 200                 205             


Glu Arg Trp Val Asn Asp Pro Gln Arg Met Asp Lys Arg Thr Leu Ala 
    210                 215                 220                 


Leu Leu Val Leu Ala His Ser Ser Asp Val Leu Glu Asn Val Phe Ser 
225                 230                 235                 240 


Ser Leu Thr Asp Asp Lys Tyr Asp Val Ala Met Asn Arg Ala Lys Asp 
                245                 250                 255     


Leu Val Glu Leu Asp Pro Glu Val Glu Gly Thr Lys Pro Ser Ala Thr 
            260                 265                 270         


Glu Met Ile Trp Ala Val Leu Ala Ala Phe Asn Lys Ser 
        275                 280                 285 


<210>  1473
<211>  657
<212>  PRT
<213>  homo sapiens

<400>  1473

Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro 
1               5                   10                  15      


Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val 
            20                  25                  30          


Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val 
        35                  40                  45              


Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu 
    50                  55                  60                  


Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val 
65                  70                  75                  80  


Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser 
                85                  90                  95      


Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys 
            100                 105                 110         


Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn 
        115                 120                 125             


Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys 
    130                 135                 140                 


Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys 
145                 150                 155                 160 


Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr 
                165                 170                 175     


Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg 
            180                 185                 190         


Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg 
        195                 200                 205             


Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
    210                 215                 220                 


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
225                 230                 235                 240 


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
                245                 250                 255     


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
            260                 265                 270         


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
        275                 280                 285             


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
    290                 295                 300                 


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
305                 310                 315                 320 


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
                325                 330                 335     


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
            340                 345                 350         


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
        355                 360                 365             


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
    370                 375                 380                 


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
385                 390                 395                 400 


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
                405                 410                 415     


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
            420                 425                 430         


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
        435                 440                 445             


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
    450                 455                 460                 


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
465                 470                 475                 480 


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
                485                 490                 495     


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
            500                 505                 510         


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
        515                 520                 525             


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
    530                 535                 540                 


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
545                 550                 555                 560 


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
                565                 570                 575     


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
            580                 585                 590         


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
        595                 600                 605             


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
    610                 615                 620                 


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
625                 630                 635                 640 


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
                645                 650                 655     


Leu 
    


<210>  1474
<211>  2144
<212>  PRT
<213>  homo sapiens

<400>  1474

Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln Ser 
1               5                   10                  15      


Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe Asp 
            20                  25                  30          


Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile Gly 
        35                  40                  45              


Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu Gln 
    50                  55                  60                  


Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg Ser 
65                  70                  75                  80  


Val Gln Thr Lys Ala Val Asn Lys Gln Leu Asp Glu Asn Ile Ser Leu 
                85                  90                  95      


Phe Leu Ile His Leu Ser Pro Tyr Phe Leu Leu Lys Pro Ala Gln Lys 
            100                 105                 110         


Cys Leu Glu Trp Leu Ile His Arg Phe His Ile His Leu Tyr Asn Gln 
        115                 120                 125             


Asp Ser Leu Ile Ala Cys Val Leu Pro Tyr His Glu Thr Arg Ile Phe 
    130                 135                 140                 


Val Arg Val Ile Gln Leu Leu Lys Ile Asn Asn Ser Lys His Arg Trp 
145                 150                 155                 160 


Phe Trp Leu Leu Pro Val Lys Gln Ser Gly Val Pro Leu Ala Lys Gly 
                165                 170                 175     


Thr Leu Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe Ile 
            180                 185                 190         


Cys Ser Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro Gly 
        195                 200                 205             


Ser Ser Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr Ile 
    210                 215                 220                 


Val Ser Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile Ala 
225                 230                 235                 240 


Lys Leu Phe Pro Tyr Ile Gln Lys Gly Leu Lys Ser Ser Leu Pro Asp 
                245                 250                 255     


Tyr Arg Ala Ala Thr Tyr Met Ile Ile Cys Gln Ile Ser Val Lys Val 
            260                 265                 270         


Thr Met Glu Asn Thr Phe Val Asn Ser Leu Ala Ser Gln Ile Ile Lys 
        275                 280                 285             


Thr Leu Thr Lys Ile Pro Ser Leu Ile Lys Asp Gly Leu Ser Cys Leu 
    290                 295                 300                 


Ile Val Leu Leu Gln Arg Gln Lys Pro Glu Ser Leu Gly Lys Lys Pro 
305                 310                 315                 320 


Phe Pro His Leu Cys Asn Val Pro Asp Leu Ile Thr Ile Leu His Gly 
                325                 330                 335     


Ile Ser Glu Thr Tyr Asp Val Ser Pro Leu Leu His Tyr Met Leu Pro 
            340                 345                 350         


His Leu Val Val Ser Ile Ile His His Val Thr Gly Glu Glu Thr Glu 
        355                 360                 365             


Gly Met Asp Gly Gln Ile Tyr Lys Arg His Leu Glu Ala Ile Leu Thr 
    370                 375                 380                 


Lys Ile Ser Leu Lys Asn Asn Leu Asp His Leu Leu Ala Ser Leu Leu 
385                 390                 395                 400 


Phe Glu Glu Tyr Ile Ser Tyr Ser Ser Gln Glu Glu Met Asp Ser Asn 
                405                 410                 415     


Lys Val Ser Leu Leu Asn Glu Gln Phe Leu Pro Leu Ile Arg Leu Leu 
            420                 425                 430         


Glu Ser Lys Tyr Pro Arg Thr Leu Asp Val Val Leu Glu Glu His Leu 
        435                 440                 445             


Lys Glu Ile Ala Asp Leu Lys Lys Gln Glu Leu Phe His Gln Phe Val 
    450                 455                 460                 


Ser Leu Ser Thr Ser Gly Gly Lys Tyr Gln Phe Leu Ala Asp Ser Asp 
465                 470                 475                 480 


Thr Ser Leu Met Leu Ser Leu Asn His Pro Leu Ala Pro Val Arg Ile 
                485                 490                 495     


Leu Ala Met Asn His Leu Lys Lys Ile Met Lys Thr Ser Lys Glu Gly 
            500                 505                 510         


Val Asp Glu Ser Phe Ile Lys Glu Ala Val Leu Ala Arg Leu Gly Asp 
        515                 520                 525             


Asp Asn Ile Asp Val Val Leu Ser Ala Ile Ser Ala Phe Glu Ile Phe 
    530                 535                 540                 


Lys Glu His Phe Ser Ser Glu Val Thr Ile Ser Asn Leu Leu Asn Leu 
545                 550                 555                 560 


Phe Gln Arg Ala Glu Leu Ser Lys Asn Gly Glu Trp Tyr Glu Val Leu 
                565                 570                 575     


Lys Ile Ala Ala Asp Ile Leu Ile Lys Glu Glu Ile Leu Ser Glu Asn 
            580                 585                 590         


Asp Gln Leu Ser Asn Gln Val Val Val Cys Leu Leu Pro Phe Met Val 
        595                 600                 605             


Ile Asn Asn Asp Asp Thr Glu Ser Ala Glu Met Lys Ile Ala Ile Tyr 
    610                 615                 620                 


Leu Ser Lys Ser Gly Ile Cys Ser Leu His Pro Leu Leu Arg Gly Trp 
625                 630                 635                 640 


Glu Glu Ala Leu Glu Asn Val Ile Lys Ser Thr Lys Pro Gly Lys Leu 
                645                 650                 655     


Ile Gly Val Ala Asn Gln Lys Met Ile Glu Leu Leu Ala Asp Asn Ile 
            660                 665                 670         


Asn Leu Gly Asp Pro Ser Ser Met Leu Lys Met Val Glu Asp Leu Ile 
        675                 680                 685             


Ser Val Gly Glu Glu Glu Ser Phe Asn Leu Lys Gln Lys Val Thr Phe 
    690                 695                 700                 


His Val Ile Leu Ser Val Leu Val Ser Cys Cys Ser Ser Leu Lys Glu 
705                 710                 715                 720 


Thr His Phe Pro Phe Ala Ile Arg Val Phe Ser Leu Leu Gln Lys Lys 
                725                 730                 735     


Ile Lys Lys Leu Glu Ser Val Ile Thr Ala Val Glu Ile Pro Ser Glu 
            740                 745                 750         


Trp His Ile Glu Leu Met Leu Asp Arg Gly Ile Pro Val Glu Leu Trp 
        755                 760                 765             


Ala His Tyr Val Glu Glu Leu Asn Ser Thr Gln Arg Val Ala Val Glu 
    770                 775                 780                 


Asp Ser Val Phe Leu Val Phe Ser Leu Lys Lys Phe Ile Tyr Ala Leu 
785                 790                 795                 800 


Lys Ala Pro Lys Ser Phe Pro Lys Gly Asp Ile Trp Trp Asn Pro Glu 
                805                 810                 815     


Gln Leu Lys Glu Asp Ser Arg Asp Tyr Leu His Leu Leu Ile Gly Leu 
            820                 825                 830         


Phe Glu Met Met Leu Asn Gly Ala Asp Ala Val His Phe Arg Val Leu 
        835                 840                 845             


Met Lys Leu Phe Ile Lys Val His Leu Glu Asp Val Phe Gln Leu Phe 
    850                 855                 860                 


Lys Phe Cys Ser Val Leu Trp Thr Tyr Gly Ser Ser Leu Ser Asn Pro 
865                 870                 875                 880 


Leu Asn Cys Ser Val Lys Thr Val Leu Gln Thr Gln Ala Leu Tyr Val 
                885                 890                 895     


Gly Cys Ala Met Leu Ser Ser Gln Lys Thr Gln Cys Lys His Gln Leu 
            900                 905                 910         


Ala Ser Ile Ser Ser Pro Val Val Thr Ser Leu Leu Ile Asn Leu Gly 
        915                 920                 925             


Ser Pro Val Lys Glu Val Arg Arg Ala Ala Ile Gln Cys Leu Gln Ala 
    930                 935                 940                 


Leu Ser Gly Val Ala Ser Pro Phe Tyr Leu Ile Ile Asp His Leu Ile 
945                 950                 955                 960 


Ser Lys Ala Glu Glu Ile Thr Ser Asp Ala Ala Tyr Val Ile Gln Asp 
                965                 970                 975     


Leu Ala Thr Leu Phe Glu Glu Leu Gln Arg Glu Lys Lys Leu Lys Ser 
            980                 985                 990         


His Gln Lys Leu Ser Glu Thr Leu  Lys Asn Leu Leu Ser  Cys Val Tyr 
        995                 1000                 1005             


Ser Cys  Pro Ser Tyr Ile Ala  Lys Asp Leu Met Lys  Val Leu Gln 
    1010                 1015                 1020             


Gly Val  Asn Gly Glu Met Val  Leu Ser Gln Leu Leu  Pro Met Ala 
    1025                 1030                 1035             


Glu Gln  Leu Leu Glu Lys Ile  Gln Lys Glu Pro Thr  Ala Val Leu 
    1040                 1045                 1050             


Lys Asp  Glu Ala Met Val Leu  His Leu Thr Leu Gly  Lys Tyr Asn 
    1055                 1060                 1065             


Glu Phe  Ser Val Ser Leu Leu  Asn Glu Asp Pro Lys  Ser Leu Asp 
    1070                 1075                 1080             


Ile Phe  Ile Lys Ala Val His  Thr Thr Lys Glu Leu  Tyr Ala Gly 
    1085                 1090                 1095             


Met Pro  Thr Ile Gln Ile Thr  Ala Leu Glu Lys Ile  Thr Lys Pro 
    1100                 1105                 1110             


Phe Phe  Ala Ala Ile Ser Asp  Glu Lys Val Gln Gln  Lys Leu Leu 
    1115                 1120                 1125             


Arg Met  Leu Phe Asp Leu Leu  Val Asn Cys Lys Asn  Ser His Cys 
    1130                 1135                 1140             


Ala Gln  Thr Val Ser Ser Val  Phe Lys Gly Ile Ser  Val Asn Ala 
    1145                 1150                 1155             


Glu Gln  Val Arg Ile Glu Leu  Glu Pro Pro Asp Lys  Ala Lys Pro 
    1160                 1165                 1170             


Leu Gly  Thr Val Gln Gln Lys  Arg Arg Gln Lys Met  Gln Gln Lys 
    1175                 1180                 1185             


Lys Ser  Gln Asp Leu Glu Ser  Val Gln Glu Val Gly  Gly Ser Tyr 
    1190                 1195                 1200             


Trp Gln  Arg Val Thr Leu Ile  Leu Glu Leu Leu Gln  His Lys Lys 
    1205                 1210                 1215             


Lys Leu  Arg Ser Pro Gln Ile  Leu Val Pro Thr Leu  Phe Asn Leu 
    1220                 1225                 1230             


Leu Ser  Arg Cys Leu Glu Pro  Leu Pro Gln Glu Gln  Gly Asn Met 
    1235                 1240                 1245             


Glu Tyr  Thr Lys Gln Leu Ile  Leu Ser Cys Leu Leu  Asn Ile Cys 
    1250                 1255                 1260             


Gln Lys  Leu Ser Pro Asp Gly  Gly Lys Ile Pro Lys  Asp Ile Leu 
    1265                 1270                 1275             


Asp Glu  Glu Lys Phe Asn Val  Glu Leu Ile Val Gln  Cys Ile Arg 
    1280                 1285                 1290             


Leu Ser  Glu Met Pro Gln Thr  His His His Ala Leu  Leu Leu Leu 
    1295                 1300                 1305             


Gly Thr  Val Ala Gly Ile Phe  Pro Asp Lys Val Leu  His Asn Ile 
    1310                 1315                 1320             


Met Ser  Ile Phe Thr Phe Met  Gly Ala Asn Val Met  Arg Leu Asp 
    1325                 1330                 1335             


Asp Thr  Tyr Ser Phe Gln Val  Ile Asn Lys Thr Val  Lys Met Val 
    1340                 1345                 1350             


Ile Pro  Ala Leu Ile Gln Ser  Asp Ser Gly Asp Ser  Ile Glu Val 
    1355                 1360                 1365             


Ser Arg  Asn Val Glu Glu Ile  Val Val Lys Ile Ile  Ser Val Phe 
    1370                 1375                 1380             


Val Asp  Ala Leu Pro His Val  Pro Glu His Arg Arg  Leu Pro Ile 
    1385                 1390                 1395             


Leu Val  Gln Leu Val Asp Thr  Leu Gly Ala Glu Lys  Phe Leu Trp 
    1400                 1405                 1410             


Ile Leu  Leu Ile Leu Leu Phe  Glu Gln Tyr Val Thr  Lys Thr Val 
    1415                 1420                 1425             


Leu Ala  Ala Ala Tyr Gly Glu  Lys Asp Ala Ile Leu  Glu Ala Asp 
    1430                 1435                 1440             


Thr Glu  Phe Trp Phe Ser Val  Cys Cys Glu Phe Ser  Val Gln His 
    1445                 1450                 1455             


Gln Ile  Gln Ser Leu Met Asn  Ile Leu Gln Tyr Leu  Leu Lys Leu 
    1460                 1465                 1470             


Pro Glu  Glu Lys Glu Glu Thr  Ile Pro Lys Ala Val  Ser Phe Asn 
    1475                 1480                 1485             


Lys Ser  Glu Ser Gln Glu Glu  Met Leu Gln Val Phe  Asn Val Glu 
    1490                 1495                 1500             


Thr His  Thr Ser Lys Gln Leu  Arg His Phe Lys Phe  Leu Ser Val 
    1505                 1510                 1515             


Ser Phe  Met Ser Gln Leu Leu  Ser Ser Asn Asn Phe  Leu Lys Lys 
    1520                 1525                 1530             


Val Val  Glu Ser Gly Gly Pro  Glu Ile Leu Lys Gly  Leu Glu Glu 
    1535                 1540                 1545             


Arg Leu  Leu Glu Thr Val Leu  Gly Tyr Ile Ser Ala  Val Ala Gln 
    1550                 1555                 1560             


Ser Met  Glu Arg Asn Ala Asp  Lys Leu Thr Val Lys  Phe Trp Arg 
    1565                 1570                 1575             


Ala Leu  Leu Ser Lys Ala Tyr  Asp Leu Leu Asp Lys  Val Asn Ala 
    1580                 1585                 1590             


Leu Leu  Pro Thr Glu Thr Phe  Ile Pro Val Ile Arg  Gly Leu Val 
    1595                 1600                 1605             


Gly Asn  Pro Leu Pro Ser Val  Arg Arg Lys Ala Leu  Asp Leu Leu 
    1610                 1615                 1620             


Asn Asn  Lys Leu Gln Gln Asn  Ile Ser Trp Lys Lys  Thr Ile Val 
    1625                 1630                 1635             


Thr Arg  Phe Leu Lys Leu Val  Pro Asp Leu Leu Ala  Ile Val Gln 
    1640                 1645                 1650             


Arg Lys  Lys Lys Glu Gly Glu  Glu Glu Gln Ala Ile  Asn Arg Gln 
    1655                 1660                 1665             


Thr Ala  Leu Tyr Thr Leu Lys  Leu Leu Cys Lys Asn  Phe Gly Ala 
    1670                 1675                 1680             


Glu Asn  Pro Asp Pro Phe Val  Pro Val Leu Asn Thr  Ala Val Lys 
    1685                 1690                 1695             


Leu Ile  Ala Pro Glu Arg Lys  Glu Glu Lys Asn Val  Leu Gly Ser 
    1700                 1705                 1710             


Ala Leu  Leu Cys Ile Ala Glu  Val Thr Ser Thr Leu  Glu Ala Leu 
    1715                 1720                 1725             


Ala Ile  Pro Gln Leu Pro Ser  Leu Met Pro Ser Leu  Leu Thr Thr 
    1730                 1735                 1740             


Met Lys  Asn Thr Ser Glu Leu  Val Ser Ser Glu Val  Tyr Leu Leu 
    1745                 1750                 1755             


Ser Ala  Leu Ala Ala Leu Gln  Lys Val Val Glu Thr  Leu Pro His 
    1760                 1765                 1770             


Phe Ile  Ser Pro Tyr Leu Glu  Gly Ile Leu Ser Gln  Val Ile His 
    1775                 1780                 1785             


Leu Glu  Lys Ile Thr Ser Glu  Met Gly Ser Ala Ser  Gln Ala Asn 
    1790                 1795                 1800             


Ile Arg  Leu Thr Ser Leu Lys  Lys Thr Leu Ala Thr  Thr Leu Ala 
    1805                 1810                 1815             


Pro Arg  Val Leu Leu Pro Ala  Ile Lys Lys Thr Tyr  Lys Gln Ile 
    1820                 1825                 1830             


Glu Lys  Asn Trp Lys Asn His  Met Gly Pro Phe Met  Ser Ile Leu 
    1835                 1840                 1845             


Gln Glu  His Ile Gly Val Met  Lys Lys Glu Glu Leu  Thr Ser His 
    1850                 1855                 1860             


Gln Ser  Gln Leu Thr Ala Phe  Phe Leu Glu Ala Leu  Asp Phe Arg 
    1865                 1870                 1875             


Ala Gln  His Ser Glu Asn Asp  Leu Glu Glu Val Gly  Lys Thr Glu 
    1880                 1885                 1890             


Asn Cys  Ile Ile Asp Cys Leu  Val Ala Met Val Val  Lys Leu Ser 
    1895                 1900                 1905             


Glu Val  Thr Phe Arg Pro Leu  Phe Phe Lys Leu Phe  Asp Trp Ala 
    1910                 1915                 1920             


Lys Thr  Glu Asp Ala Pro Lys  Asp Arg Leu Leu Thr  Phe Tyr Asn 
    1925                 1930                 1935             


Leu Ala  Asp Cys Ile Ala Glu  Lys Leu Lys Gly Leu  Phe Thr Leu 
    1940                 1945                 1950             


Phe Ala  Gly His Leu Val Lys  Pro Phe Ala Asp Thr  Leu Asn Gln 
    1955                 1960                 1965             


Val Asn  Ile Ser Lys Thr Asp  Glu Ala Phe Phe Asp  Ser Glu Asn 
    1970                 1975                 1980             


Asp Pro  Glu Lys Cys Cys Leu  Leu Leu Gln Phe Ile  Leu Asn Cys 
    1985                 1990                 1995             


Leu Tyr  Lys Ile Phe Leu Phe  Asp Thr Gln His Phe  Ile Ser Lys 
    2000                 2005                 2010             


Glu Arg  Ala Glu Ala Leu Met  Met Pro Leu Val Asp  Gln Leu Glu 
    2015                 2020                 2025             


Asn Arg  Leu Gly Gly Glu Glu  Lys Phe Gln Glu Arg  Val Thr Lys 
    2030                 2035                 2040             


His Leu  Ile Pro Cys Ile Ala  Gln Phe Ser Val Ala  Met Ala Asp 
    2045                 2050                 2055             


Asp Ser  Leu Trp Lys Pro Leu  Asn Tyr Gln Ile Leu  Leu Lys Thr 
    2060                 2065                 2070             


Arg Asp  Ser Ser Pro Lys Val  Arg Phe Ala Ala Leu  Ile Thr Val 
    2075                 2080                 2085             


Leu Ala  Leu Ala Glu Lys Leu  Lys Glu Asn Tyr Ile  Val Leu Leu 
    2090                 2095                 2100             


Pro Glu  Ser Ile Pro Phe Leu  Ala Glu Leu Met Glu  Asp Glu Cys 
    2105                 2110                 2115             


Glu Glu  Val Glu His Gln Cys  Gln Lys Thr Ile Gln  Gln Leu Glu 
    2120                 2125                 2130             


Thr Val  Leu Gly Glu Pro Leu  Gln Ser Tyr Phe 
    2135                 2140                 


<210>  1475
<211>  205
<212>  PRT
<213>  homo sapiens

<400>  1475

Met Ala Glu Pro Leu Gln Pro Asp Pro Gly Ala Ala Glu Asp Ala Ala 
1               5                   10                  15      


Ala Gln Ala Val Glu Thr Pro Gly Trp Lys Ala Pro Glu Asp Ala Gly 
            20                  25                  30          


Pro Gln Pro Gly Ser Tyr Glu Ile Arg His Tyr Gly Pro Ala Lys Trp 
        35                  40                  45              


Val Ser Thr Ser Val Glu Ser Met Asp Trp Asp Ser Ala Ile Gln Thr 
    50                  55                  60                  


Gly Phe Thr Lys Leu Asn Ser Tyr Ile Gln Gly Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Met Lys Ile Lys Met Thr Ala Pro Val Thr Ser Tyr Val Glu Pro Gly 
                85                  90                  95      


Ser Gly Pro Phe Ser Glu Ser Thr Ile Thr Ile Ser Leu Tyr Ile Pro 
            100                 105                 110         


Ser Glu Gln Gln Phe Asp Pro Pro Arg Pro Leu Glu Ser Asp Val Phe 
        115                 120                 125             


Ile Glu Asp Arg Ala Glu Met Thr Val Phe Val Arg Ser Phe Asp Gly 
    130                 135                 140                 


Phe Ser Ser Ala Gln Lys Asn Gln Glu Gln Leu Leu Thr Leu Ala Ser 
145                 150                 155                 160 


Ile Leu Arg Glu Asp Gly Lys Val Phe Asp Glu Lys Val Tyr Tyr Thr 
                165                 170                 175     


Ala Gly Tyr Asn Ser Pro Val Lys Leu Leu Asn Arg Asn Asn Glu Val 
            180                 185                 190         


Trp Leu Ile Gln Lys Asn Glu Pro Thr Lys Glu Asn Glu 
        195                 200                 205 


<210>  1476
<211>  386
<212>  PRT
<213>  homo sapiens

<400>  1476

Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe 
1               5                   10                  15      


Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr 
            20                  25                  30          


Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val 
        35                  40                  45              


Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met 
    50                  55                  60                  


Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu 
65                  70                  75                  80  


Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala 
                85                  90                  95      


Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys 
            100                 105                 110         


Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val 
        115                 120                 125             


Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met 
    130                 135                 140                 


Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr 
145                 150                 155                 160 


Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro 
                165                 170                 175     


Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly 
            180                 185                 190         


Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr 
        195                 200                 205             


Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met 
    210                 215                 220                 


Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile 
225                 230                 235                 240 


Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp 
                245                 250                 255     


Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe 
            260                 265                 270         


Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly 
        275                 280                 285             


Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro 
    290                 295                 300                 


Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys 
305                 310                 315                 320 


Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys 
                325                 330                 335     


Met Arg Gly His Asp Phe His Glu Gly Val Arg Ala Val Leu Ile Asp 
            340                 345                 350         


Lys Asp Gln Ser Pro Lys Trp Lys Pro Ala Asp Leu Lys Glu Val Thr 
        355                 360                 365             


Glu Glu Asp Leu Asn Asn His Phe Lys Ser Leu Gly Ser Ser Asp Leu 
    370                 375                 380                 


Lys Phe 
385     


<210>  1477
<211>  1009
<212>  PRT
<213>  homo sapiens

<400>  1477

Met Ser Trp Met Phe Lys Arg Asp Pro Val Trp Lys Tyr Leu Gln Thr 
1               5                   10                  15      


Val Gln Tyr Gly Val His Gly Asn Phe Pro Arg Leu Ser Tyr Pro Thr 
            20                  25                  30          


Phe Phe Pro Arg Phe Glu Phe Gln Asp Val Ile Pro Pro Asp Asp Phe 
        35                  40                  45              


Leu Thr Ser Asp Glu Glu Val Asp Ser Val Leu Phe Gly Ser Leu Arg 
    50                  55                  60                  


Gly His Val Val Gly Leu Arg Tyr Tyr Thr Gly Val Val Asn Asn Asn 
65                  70                  75                  80  


Glu Met Val Ala Leu Gln Arg Asp Pro Asn Asn Pro Tyr Asp Lys Asn 
                85                  90                  95      


Ala Ile Lys Val Asn Asn Val Asn Gly Asn Gln Val Gly His Leu Lys 
            100                 105                 110         


Lys Glu Leu Ala Gly Ala Leu Ala Tyr Ile Met Asp Asn Lys Leu Ala 
        115                 120                 125             


Gln Ile Glu Gly Val Val Pro Phe Gly Ala Asn Asn Ala Phe Thr Met 
    130                 135                 140                 


Pro Leu His Met Thr Phe Trp Gly Lys Glu Glu Asn Arg Lys Ala Val 
145                 150                 155                 160 


Ser Asp Gln Leu Lys Lys His Gly Phe Lys Leu Gly Pro Ala Pro Lys 
                165                 170                 175     


Thr Leu Gly Phe Asn Leu Glu Ser Gly Trp Gly Ser Gly Arg Ala Gly 
            180                 185                 190         


Pro Ser Tyr Ser Met Pro Val His Ala Ala Val Gln Met Thr Thr Glu 
        195                 200                 205             


Gln Leu Lys Thr Glu Phe Asp Lys Leu Phe Glu Asp Leu Lys Glu Asp 
    210                 215                 220                 


Asp Lys Thr His Glu Met Glu Pro Ala Glu Ala Ile Glu Thr Pro Leu 
225                 230                 235                 240 


Leu Pro His Gln Lys Gln Ala Leu Ala Trp Met Val Ser Arg Glu Asn 
                245                 250                 255     


Ser Lys Glu Leu Pro Pro Phe Trp Glu Gln Arg Asn Asp Leu Tyr Tyr 
            260                 265                 270         


Asn Thr Ile Thr Asn Phe Ser Glu Lys Asp Arg Pro Glu Asn Val His 
        275                 280                 285             


Gly Gly Ile Leu Ala Asp Asp Met Gly Leu Gly Lys Thr Leu Thr Ala 
    290                 295                 300                 


Ile Ala Val Ile Leu Thr Asn Phe His Asp Gly Arg Pro Leu Pro Ile 
305                 310                 315                 320 


Glu Arg Val Lys Lys Asn Leu Leu Lys Lys Glu Tyr Asn Val Asn Asp 
                325                 330                 335     


Asp Ser Met Lys Leu Gly Gly Asn Asn Thr Ser Glu Lys Ala Asp Gly 
            340                 345                 350         


Leu Ser Lys Asp Ala Ser Arg Cys Ser Glu Gln Pro Ser Ile Ser Asp 
        355                 360                 365             


Ile Lys Glu Lys Ser Lys Phe Arg Met Ser Glu Leu Ser Ser Ser Arg 
    370                 375                 380                 


Pro Lys Arg Arg Lys Thr Ala Val Gln Tyr Ile Glu Ser Ser Asp Ser 
385                 390                 395                 400 


Glu Glu Ile Glu Thr Ser Glu Leu Pro Gln Lys Met Lys Gly Lys Leu 
                405                 410                 415     


Lys Asn Val Gln Ser Glu Thr Lys Gly Arg Ala Lys Ala Gly Ser Ser 
            420                 425                 430         


Lys Val Ile Glu Asp Val Ala Phe Ala Cys Ala Leu Thr Ser Ser Val 
        435                 440                 445             


Pro Thr Thr Lys Lys Lys Met Leu Lys Lys Gly Ala Cys Ala Val Glu 
    450                 455                 460                 


Gly Ser Lys Lys Thr Asp Val Glu Glu Arg Pro Arg Thr Thr Leu Ile 
465                 470                 475                 480 


Ile Cys Pro Leu Ser Val Leu Ser Asn Trp Ile Asp Gln Phe Gly Gln 
                485                 490                 495     


His Ile Lys Ser Asp Val His Leu Asn Phe Tyr Val Tyr Tyr Gly Pro 
            500                 505                 510         


Asp Arg Ile Arg Glu Pro Ala Leu Leu Ser Lys Gln Asp Ile Val Leu 
        515                 520                 525             


Thr Thr Tyr Asn Ile Leu Thr His Asp Tyr Gly Thr Lys Gly Asp Ser 
    530                 535                 540                 


Pro Leu His Ser Ile Arg Trp Leu Arg Val Ile Leu Asp Glu Gly His 
545                 550                 555                 560 


Ala Ile Arg Asn Pro Asn Ala Gln Gln Thr Lys Ala Val Leu Asp Leu 
                565                 570                 575     


Glu Ser Glu Arg Arg Trp Val Leu Thr Gly Thr Pro Ile Gln Asn Ser 
            580                 585                 590         


Leu Lys Asp Leu Trp Ser Leu Leu Ser Phe Leu Lys Leu Lys Pro Phe 
        595                 600                 605             


Ile Asp Arg Glu Trp Trp His Arg Thr Ile Gln Arg Pro Val Thr Met 
    610                 615                 620                 


Gly Asp Glu Gly Gly Leu Arg Arg Leu Gln Ser Leu Ile Lys Asn Ile 
625                 630                 635                 640 


Thr Leu Arg Arg Thr Lys Thr Ser Lys Ile Lys Gly Lys Pro Val Leu 
                645                 650                 655     


Glu Leu Pro Glu Arg Lys Val Phe Ile Gln His Ile Thr Leu Ser Asp 
            660                 665                 670         


Glu Glu Arg Lys Ile Tyr Gln Ser Val Lys Asn Glu Gly Arg Ala Thr 
        675                 680                 685             


Ile Gly Arg Tyr Phe Asn Glu Gly Thr Val Leu Ala His Tyr Ala Asp 
    690                 695                 700                 


Val Leu Gly Leu Leu Leu Arg Leu Arg Gln Ile Cys Cys His Thr Tyr 
705                 710                 715                 720 


Leu Leu Thr Asn Ala Val Ser Ser Asn Gly Pro Ser Gly Asn Asp Thr 
                725                 730                 735     


Pro Glu Glu Leu Arg Lys Lys Leu Ile Arg Lys Met Lys Leu Ile Leu 
            740                 745                 750         


Ser Ser Gly Ser Asp Glu Glu Cys Ala Ile Cys Leu Asp Ser Leu Thr 
        755                 760                 765             


Val Pro Val Ile Thr His Cys Ala His Val Phe Cys Lys Pro Cys Ile 
    770                 775                 780                 


Cys Gln Val Ile Gln Asn Glu Gln Pro His Ala Lys Cys Pro Leu Cys 
785                 790                 795                 800 


Arg Asn Asp Ile His Glu Asp Asn Leu Leu Glu Cys Pro Pro Glu Glu 
                805                 810                 815     


Leu Ala Arg Asp Ser Glu Lys Lys Ser Asp Met Glu Trp Thr Ser Ser 
            820                 825                 830         


Ser Lys Ile Asn Ala Leu Met His Ala Leu Thr Asp Leu Arg Lys Lys 
        835                 840                 845             


Asn Pro Asn Ile Lys Ser Leu Val Val Ser Gln Phe Thr Thr Phe Leu 
    850                 855                 860                 


Ser Leu Ile Glu Ile Pro Leu Lys Ala Ser Gly Phe Val Phe Thr Arg 
865                 870                 875                 880 


Leu Asp Gly Ser Met Ala Gln Lys Lys Arg Val Glu Ser Ile Gln Cys 
                885                 890                 895     


Phe Gln Asn Thr Glu Ala Gly Ser Pro Thr Ile Met Leu Leu Ser Leu 
            900                 905                 910         


Lys Ala Gly Gly Val Gly Leu Asn Leu Ser Ala Ala Ser Arg Val Phe 
        915                 920                 925             


Leu Met Asp Pro Ala Trp Asn Pro Ala Ala Glu Asp Gln Cys Phe Asp 
    930                 935                 940                 


Arg Cys His Arg Leu Gly Gln Lys Gln Glu Val Ile Ile Thr Lys Phe 
945                 950                 955                 960 


Ile Val Lys Asp Ser Val Glu Glu Asn Met Leu Lys Ile Gln Asn Lys 
                965                 970                 975     


Lys Arg Glu Leu Ala Ala Gly Ala Phe Gly Thr Lys Lys Pro Asn Ala 
            980                 985                 990         


Asp Glu Met Lys Gln Ala Lys Ile  Asn Glu Ile Arg Thr  Leu Ile Asp 
        995                 1000                 1005             


Leu 
    


<210>  1478
<211>  390
<212>  PRT
<213>  homo sapiens

<400>  1478

Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val 
1               5                   10                  15      


Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met Leu Gly 
            20                  25                  30          


Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys Asn Leu Arg His 
        35                  40                  45              


Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala Ile Ser Asp Phe Phe Val 
    50                  55                  60                  


Gly Val Ile Ser Ile Pro Leu Tyr Ile Pro His Thr Leu Phe Glu Trp 
65                  70                  75                  80  


Asp Phe Gly Lys Glu Ile Cys Val Phe Trp Leu Thr Thr Asp Tyr Leu 
                85                  90                  95      


Leu Cys Thr Ala Ser Val Tyr Asn Ile Val Leu Ile Ser Tyr Asp Arg 
            100                 105                 110         


Tyr Leu Ser Val Ser Asn Ala Val Ser Tyr Arg Thr Gln His Thr Gly 
        115                 120                 125             


Val Leu Lys Ile Val Thr Leu Met Val Ala Val Trp Val Leu Ala Phe 
    130                 135                 140                 


Leu Val Asn Gly Pro Met Ile Leu Val Ser Glu Ser Trp Lys Asp Glu 
145                 150                 155                 160 


Gly Ser Glu Cys Glu Pro Gly Phe Phe Ser Glu Trp Tyr Ile Leu Ala 
                165                 170                 175     


Ile Thr Ser Phe Leu Glu Phe Val Ile Pro Val Ile Leu Val Ala Tyr 
            180                 185                 190         


Phe Asn Met Asn Ile Tyr Trp Ser Leu Trp Lys Arg Asp His Leu Ser 
        195                 200                 205             


Arg Cys Gln Ser His Pro Gly Leu Thr Ala Val Ser Ser Asn Ile Cys 
    210                 215                 220                 


Gly His Ser Phe Arg Gly Arg Leu Ser Ser Arg Arg Ser Leu Ser Ala 
225                 230                 235                 240 


Ser Thr Glu Val Pro Ala Ser Phe His Ser Glu Arg Gln Arg Arg Lys 
                245                 250                 255     


Ser Ser Leu Met Phe Ser Ser Arg Thr Lys Met Asn Ser Asn Thr Ile 
            260                 265                 270         


Ala Ser Lys Met Gly Ser Phe Ser Gln Ser Asp Ser Val Ala Leu His 
        275                 280                 285             


Gln Arg Glu His Val Glu Leu Leu Arg Ala Arg Arg Leu Ala Lys Ser 
    290                 295                 300                 


Leu Ala Ile Leu Leu Gly Val Phe Ala Val Cys Trp Ala Pro Tyr Ser 
305                 310                 315                 320 


Leu Phe Thr Ile Val Leu Ser Phe Tyr Ser Ser Ala Thr Gly Pro Lys 
                325                 330                 335     


Ser Val Trp Tyr Arg Ile Ala Phe Trp Leu Gln Trp Phe Asn Ser Phe 
            340                 345                 350         


Val Asn Pro Leu Leu Tyr Pro Leu Cys His Lys Arg Phe Gln Lys Ala 
        355                 360                 365             


Phe Leu Lys Ile Phe Cys Ile Lys Lys Gln Pro Leu Pro Ser Gln His 
    370                 375                 380                 


Ser Arg Ser Val Ser Ser 
385                 390 


<210>  1479
<211>  1019
<212>  PRT
<213>  homo sapiens

<400>  1479

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Ala Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser Leu Asn Glu Tyr Ala 
        595                 600                 605             


Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp Leu Gln Asn Thr Ile 
    610                 615                 620                 


Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Gly Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  1480
<211>  2491
<212>  PRT
<213>  homo sapiens

<400>  1480

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Arg Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210>  1481
<211>  1332
<212>  PRT
<213>  homo sapiens

<400>  1481

Met Arg Asn Leu Lys Leu Phe Arg Thr Leu Glu Phe Arg Asp Ile Gln 
1               5                   10                  15      


Gly Pro Gly Asn Pro Gln Cys Phe Ser Leu Arg Thr Glu Gln Gly Thr 
            20                  25                  30          


Val Leu Ile Gly Ser Glu His Gly Leu Ile Glu Val Asp Pro Val Ser 
        35                  40                  45              


Arg Glu Val Lys Asn Glu Val Ser Leu Val Ala Glu Gly Phe Leu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Gly Arg Ile Val Gly Val Gln Asp Leu Leu Asp Gln 
65                  70                  75                  80  


Glu Ser Val Cys Val Ala Thr Ala Ser Gly Asp Val Ile Leu Cys Ser 
                85                  90                  95      


Leu Ser Thr Gln Gln Leu Glu Cys Val Gly Ser Val Ala Ser Gly Ile 
            100                 105                 110         


Ser Val Met Ser Trp Ser Pro Asp Gln Glu Leu Val Leu Leu Ala Thr 
        115                 120                 125             


Gly Gln Gln Thr Leu Ile Met Met Thr Lys Asp Phe Glu Pro Ile Leu 
    130                 135                 140                 


Glu Gln Gln Ile His Gln Asp Asp Phe Gly Glu Ser Lys Phe Ile Thr 
145                 150                 155                 160 


Val Gly Trp Gly Arg Lys Glu Thr Gln Phe His Gly Ser Glu Gly Arg 
                165                 170                 175     


Gln Ala Ala Phe Gln Met Gln Met His Glu Ser Ala Leu Pro Trp Asp 
            180                 185                 190         


Asp His Arg Pro Gln Val Thr Trp Arg Gly Asp Gly Gln Phe Phe Ala 
        195                 200                 205             


Val Ser Val Val Cys Pro Glu Thr Gly Ala Arg Lys Val Arg Val Trp 
    210                 215                 220                 


Asn Arg Glu Phe Ala Leu Gln Ser Thr Ser Glu Pro Val Ala Gly Leu 
225                 230                 235                 240 


Gly Pro Ala Leu Ala Trp Lys Pro Ser Gly Ser Leu Ile Ala Ser Thr 
                245                 250                 255     


Gln Asp Lys Pro Asn Gln Gln Asp Ile Val Phe Phe Glu Lys Asn Gly 
            260                 265                 270         


Leu Leu His Gly His Phe Thr Leu Pro Phe Leu Lys Asp Glu Val Lys 
        275                 280                 285             


Val Asn Asp Leu Leu Trp Asn Ala Asp Ser Ser Val Leu Ala Val Trp 
    290                 295                 300                 


Leu Glu Asp Leu Gln Arg Glu Glu Ser Ser Ile Pro Lys Thr Cys Val 
305                 310                 315                 320 


Gln Leu Trp Thr Val Gly Asn Tyr His Trp Tyr Leu Lys Gln Ser Leu 
                325                 330                 335     


Ser Phe Ser Thr Cys Gly Lys Ser Lys Ile Val Ser Leu Met Trp Asp 
            340                 345                 350         


Pro Val Thr Pro Tyr Arg Leu His Val Leu Cys Gln Gly Trp His Tyr 
        355                 360                 365             


Leu Ala Tyr Asp Trp His Trp Thr Thr Asp Arg Ser Val Gly Asp Asn 
    370                 375                 380                 


Ser Ser Asp Leu Ser Asn Val Ala Val Ile Asp Gly Asn Arg Val Leu 
385                 390                 395                 400 


Val Thr Val Phe Arg Gln Thr Val Val Pro Pro Pro Met Cys Thr Tyr 
                405                 410                 415     


Gln Leu Leu Phe Pro His Pro Val Asn Gln Val Thr Phe Leu Ala His 
            420                 425                 430         


Pro Gln Lys Ser Asn Asp Leu Ala Val Leu Asp Ala Ser Asn Gln Ile 
        435                 440                 445             


Ser Val Tyr Lys Cys Gly Asp Cys Pro Ser Ala Asp Pro Thr Val Lys 
    450                 455                 460                 


Leu Gly Ala Val Gly Gly Ser Gly Phe Lys Val Cys Leu Arg Thr Pro 
465                 470                 475                 480 


His Leu Glu Lys Arg Tyr Lys Ile Gln Phe Glu Asn Asn Glu Asp Gln 
                485                 490                 495     


Asp Val Asn Pro Leu Lys Leu Gly Leu Leu Thr Trp Ile Glu Glu Asp 
            500                 505                 510         


Val Phe Leu Ala Val Ser His Ser Glu Phe Ser Pro Arg Ser Val Ile 
        515                 520                 525             


His His Leu Thr Ala Ala Ser Ser Glu Met Asp Glu Glu His Gly Gln 
    530                 535                 540                 


Leu Asn Val Ser Ser Ser Ala Ala Val Asp Gly Val Ile Ile Ser Leu 
545                 550                 555                 560 


Cys Cys Asn Ser Lys Thr Lys Ser Val Val Leu Gln Leu Ala Asp Gly 
                565                 570                 575     


Gln Ile Phe Lys Tyr Leu Trp Glu Ser Pro Ser Leu Ala Ile Lys Pro 
            580                 585                 590         


Trp Lys Asn Ser Gly Gly Phe Pro Val Arg Phe Pro Tyr Pro Cys Thr 
        595                 600                 605             


Gln Thr Glu Leu Ala Met Ile Gly Glu Glu Glu Cys Val Leu Gly Leu 
    610                 615                 620                 


Thr Asp Arg Cys Arg Phe Phe Ile Asn Asp Ile Glu Val Ala Ser Asn 
625                 630                 635                 640 


Ile Thr Ser Phe Ala Val Tyr Asp Glu Phe Leu Leu Leu Thr Thr His 
                645                 650                 655     


Ser His Thr Cys Gln Cys Phe Cys Leu Arg Asp Ala Ser Phe Lys Thr 
            660                 665                 670         


Leu Gln Ala Gly Leu Ser Ser Asn His Val Ser His Gly Glu Val Leu 
        675                 680                 685             


Arg Lys Val Glu Arg Gly Ser Arg Ile Val Thr Val Val Pro Gln Asp 
    690                 695                 700                 


Thr Lys Leu Val Leu Gln Met Pro Arg Gly Asn Leu Glu Val Val His 
705                 710                 715                 720 


His Arg Ala Leu Val Leu Ala Gln Ile Arg Lys Trp Leu Asp Lys Leu 
                725                 730                 735     


Met Phe Lys Glu Ala Phe Glu Cys Met Arg Lys Leu Arg Ile Asn Leu 
            740                 745                 750         


Asn Leu Ile Tyr Asp His Asn Pro Lys Val Phe Leu Gly Asn Val Glu 
        755                 760                 765             


Thr Phe Ile Lys Gln Ile Asp Ser Val Asn His Ile Asn Leu Phe Phe 
    770                 775                 780                 


Thr Glu Leu Lys Glu Glu Asp Val Thr Lys Thr Met Tyr Pro Ala Pro 
785                 790                 795                 800 


Val Thr Ser Ser Val Tyr Leu Ser Arg Asp Pro Asp Gly Asn Lys Ile 
                805                 810                 815     


Asp Leu Val Cys Asp Ala Met Arg Ala Val Met Glu Ser Ile Asn Pro 
            820                 825                 830         


His Lys Tyr Cys Leu Ser Ile Leu Thr Ser His Val Lys Lys Thr Thr 
        835                 840                 845             


Pro Glu Leu Glu Ile Val Leu Gln Lys Val His Glu Leu Gln Gly Asn 
    850                 855                 860                 


Ala Pro Ser Asp Pro Asp Ala Val Ser Ala Glu Glu Ala Leu Lys Tyr 
865                 870                 875                 880 


Leu Leu His Leu Val Asp Val Asn Glu Leu Tyr Asp His Ser Leu Gly 
                885                 890                 895     


Thr Tyr Asp Phe Asp Leu Val Leu Met Val Ala Glu Lys Ser Gln Lys 
            900                 905                 910         


Asp Pro Lys Glu Tyr Leu Pro Phe Leu Asn Thr Leu Lys Lys Met Glu 
        915                 920                 925             


Thr Asn Tyr Gln Arg Phe Thr Ile Asp Lys Tyr Leu Lys Arg Tyr Glu 
    930                 935                 940                 


Lys Ala Ile Gly His Leu Ser Lys Cys Gly Pro Glu Tyr Phe Pro Glu 
945                 950                 955                 960 


Cys Leu Asn Leu Ile Lys Asp Lys Asn Leu Tyr Asn Glu Ala Leu Lys 
                965                 970                 975     


Leu Tyr Ser Pro Ser Ser Gln Gln Tyr Gln Asp Ile Ser Ile Ala Tyr 
            980                 985                 990         


Gly Glu His Leu Met Gln Glu His  Met Tyr Glu Pro Ala  Gly Leu Met 
        995                 1000                 1005             


Phe Ala  Arg Cys Gly Ala His  Glu Lys Ala Leu Ser  Ala Phe Leu 
    1010                 1015                 1020             


Thr Cys  Gly Asn Trp Lys Gln  Ala Leu Cys Val Ala  Ala Gln Leu 
    1025                 1030                 1035             


Asn Phe  Thr Lys Asp Gln Leu  Val Gly Leu Gly Arg  Thr Leu Ala 
    1040                 1045                 1050             


Gly Lys  Leu Val Glu Gln Arg  Lys His Ile Asp Ala  Ala Met Val 
    1055                 1060                 1065             


Leu Glu  Glu Cys Ala Gln Asp  Tyr Glu Glu Ala Val  Leu Leu Leu 
    1070                 1075                 1080             


Leu Glu  Gly Ala Ala Trp Glu  Glu Ala Leu Arg Leu  Val Tyr Lys 
    1085                 1090                 1095             


Tyr Asn  Arg Leu Asp Ile Ile  Glu Thr Asn Val Lys  Pro Ser Ile 
    1100                 1105                 1110             


Leu Glu  Ala Gln Lys Asn Tyr  Met Ala Phe Leu Asp  Ser Gln Thr 
    1115                 1120                 1125             


Ala Thr  Phe Ser Arg His Lys  Lys Arg Leu Leu Val  Val Arg Glu 
    1130                 1135                 1140             


Leu Lys  Glu Gln Ala Gln Gln  Ala Gly Leu Asp Asp  Glu Val Pro 
    1145                 1150                 1155             


His Gly  Gln Glu Ser Asp Leu  Phe Ser Glu Thr Ser  Ser Val Val 
    1160                 1165                 1170             


Ser Gly  Ser Glu Met Ser Gly  Lys Tyr Ser His Ser  Asn Ser Arg 
    1175                 1180                 1185             


Ile Ser  Ala Arg Ser Ser Lys  Asn Arg Arg Lys Ala  Glu Arg Lys 
    1190                 1195                 1200             


Lys His  Ser Leu Lys Glu Gly  Ser Pro Leu Glu Asp  Leu Ala Leu 
    1205                 1210                 1215             


Leu Glu  Ala Leu Ser Glu Val  Val Gln Asn Thr Glu  Asn Leu Lys 
    1220                 1225                 1230             


Asp Glu  Val Tyr His Ile Leu  Lys Val Leu Phe Leu  Phe Glu Phe 
    1235                 1240                 1245             


Asp Glu  Gln Gly Arg Glu Leu  Gln Lys Ala Phe Glu  Asp Thr Leu 
    1250                 1255                 1260             


Gln Leu  Met Glu Arg Ser Leu  Pro Glu Ile Trp Thr  Leu Thr Tyr 
    1265                 1270                 1275             


Gln Gln  Asn Ser Ala Thr Pro  Val Leu Gly Pro Asn  Ser Thr Ala 
    1280                 1285                 1290             


Asn Ser  Ile Met Ala Ser Tyr  Gln Gln Gln Lys Thr  Ser Val Pro 
    1295                 1300                 1305             


Val Leu  Asp Ala Glu Leu Phe  Ile Pro Pro Lys Ile  Asn Arg Arg 
    1310                 1315                 1320             


Thr Gln  Trp Lys Leu Ser Leu  Leu Asp 
    1325                 1330         


<210>  1482
<211>  1038
<212>  PRT
<213>  homo sapiens

<400>  1482

Met Asp Pro Asn Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro 
1               5                   10                  15      


Ala Leu Arg Glu Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser 
            20                  25                  30          


Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu 
        35                  40                  45              


Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile 
    50                  55                  60                  


Thr Gln Tyr Trp Pro Asp Arg Glu Thr Ala Pro Gly Asp Ile Ser Pro 
65                  70                  75                  80  


Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val 
                85                  90                  95      


Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr 
            100                 105                 110         


Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala 
        115                 120                 125             


Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys 
    130                 135                 140                 


Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu 
145                 150                 155                 160 


Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His 
                165                 170                 175     


Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln 
            180                 185                 190         


Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr 
        195                 200                 205             


Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn 
    210                 215                 220                 


Leu Thr Glu Trp Ile Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val 
225                 230                 235                 240 


Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro 
                245                 250                 255     


Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe 
            260                 265                 270         


Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe 
        275                 280                 285             


Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu 
    290                 295                 300                 


Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg 
305                 310                 315                 320 


Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala 
                325                 330                 335     


Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp 
            340                 345                 350         


Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp 
        355                 360                 365             


Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu 
    370                 375                 380                 


Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala 
385                 390                 395                 400 


Cys Ser Lys Arg Lys Glu Val Leu Gln Lys Thr Met Gly Phe Cys Tyr 
                405                 410                 415     


Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly Ala 
            420                 425                 430         


Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys Ile 
        435                 440                 445             


Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His Val Phe Pro Leu 
    450                 455                 460                 


Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val Leu 
465                 470                 475                 480 


His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln Thr 
                485                 490                 495     


Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met Pro 
            500                 505                 510         


Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn Gln 
        515                 520                 525             


Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met Gln 
    530                 535                 540                 


Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr Asn 
545                 550                 555                 560 


Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro Ile 
                565                 570                 575     


Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val Ile 
            580                 585                 590         


Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr Ala 
        595                 600                 605             


Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu Asp 
    610                 615                 620                 


His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val Ile 
625                 630                 635                 640 


Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile Phe 
                645                 650                 655     


Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met Trp 
            660                 665                 670         


Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe Asp 
        675                 680                 685             


Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val Asp 
    690                 695                 700                 


Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr Ser 
705                 710                 715                 720 


Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu Cys 
                725                 730                 735     


His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly Arg 
            740                 745                 750         


Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu Arg 
        755                 760                 765             


Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr Met Cys Leu Gln 
    770                 775                 780                 


Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu Leu Leu Asn Thr 
785                 790                 795                 800 


Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro Val Thr Asn His 
                805                 810                 815     


Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu His 
            820                 825                 830         


Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu Ile Asp Met Glu 
        835                 840                 845             


Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln Ile Leu Pro Ala 
    850                 855                 860                 


Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His Ala 
865                 870                 875                 880 


Glu His Glu Asn Asp Ser Asp Asp Asp Asp Glu Ala Glu Asp Asp Asp 
                885                 890                 895     


Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp Gly 
            900                 905                 910         


Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly Asp 
        915                 920                 925             


Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu Gly 
    930                 935                 940                 


Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr Gln 
945                 950                 955                 960 


Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val Trp 
                965                 970                 975     


Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln Leu 
            980                 985                 990         


Gln Asp Ile Ala Thr Leu Ala Asp  Gln Arg Arg Ala Ala  His Glu Ser 
        995                 1000                 1005             


Lys Met  Ile Glu Lys His Gly  Gly Tyr Lys Phe Ser  Ala Pro Val 
    1010                 1015                 1020             


Val Pro  Ser Ser Phe Asn Phe  Gly Gly Pro Ala Pro  Gly Met Asn 
    1025                 1030                 1035             


<210>  1483
<211>  598
<212>  PRT
<213>  homo sapiens

<400>  1483

Met Lys Pro Thr Gly Thr Asp Pro Arg Ile Leu Ser Ile Ala Ala Glu 
1               5                   10                  15      


Val Ala Lys Ser Pro Glu Gln Asn Val Pro Val Ile Leu Leu Lys Leu 
            20                  25                  30          


Lys Glu Ile Ile Asn Ile Thr Pro Leu Gly Ser Ser Glu Leu Lys Lys 
        35                  40                  45              


Ile Lys Gln Asp Ile Tyr Cys Tyr Asp Leu Ile Gln Tyr Cys Leu Leu 
    50                  55                  60                  


Val Leu Ser Gln Asp Tyr Ser Arg Ile Gln Gly Gly Trp Thr Thr Ile 
65                  70                  75                  80  


Ser Gln Leu Thr Gln Ile Leu Ser His Cys Cys Val Gly Leu Glu Pro 
                85                  90                  95      


Gly Glu Asp Ala Glu Glu Phe Tyr Asn Glu Leu Leu Pro Ser Ala Ala 
            100                 105                 110         


Glu Asn Phe Leu Val Leu Gly Arg Gln Leu Gln Thr Cys Phe Ile Asn 
        115                 120                 125             


Ala Ala Lys Ala Glu Glu Lys Asp Glu Leu Leu His Phe Phe Gln Ile 
    130                 135                 140                 


Val Thr Asp Ser Leu Phe Trp Leu Leu Gly Gly His Val Glu Leu Ile 
145                 150                 155                 160 


Gln Asn Val Leu Gln Ser Asp His Phe Leu His Leu Leu Gln Ala Asp 
                165                 170                 175     


Asn Val Gln Ile Gly Ser Ala Val Met Met Met Leu Gln Asn Ile Leu 
            180                 185                 190         


Gln Ile Asn Ser Gly Asp Leu Leu Arg Ile Gly Arg Lys Ala Leu Tyr 
        195                 200                 205             


Ser Ile Leu Asp Glu Val Ile Phe Lys Leu Phe Ser Thr Pro Ser Pro 
    210                 215                 220                 


Val Ile Arg Ser Thr Ala Thr Lys Leu Leu Leu Leu Met Ala Glu Ser 
225                 230                 235                 240 


His Gln Glu Ile Leu Ile Leu Leu Arg Gln Ser Thr Cys Tyr Lys Gly 
                245                 250                 255     


Leu Arg Arg Leu Leu Ser Lys Gln Glu Thr Gly Thr Glu Phe Ser Gln 
            260                 265                 270         


Glu Leu Arg Gln Leu Val Gly Leu Leu Ser Pro Met Val Tyr Gln Glu 
        275                 280                 285             


Val Glu Glu Gln Lys Leu His Gln Ala Ala Cys Leu Ile Gln Ala Tyr 
    290                 295                 300                 


Trp Lys Gly Phe Gln Thr Arg Lys Arg Leu Lys Lys Leu Pro Ser Ala 
305                 310                 315                 320 


Val Ile Ala Leu Gln Arg Ser Phe Arg Ser Lys Arg Ser Lys Met Leu 
                325                 330                 335     


Leu Glu Ile Asn Arg Gln Lys Glu Glu Glu Asp Leu Lys Leu Gln Leu 
            340                 345                 350         


Gln Leu Gln Arg Gln Arg Ala Met Arg Leu Ser Arg Glu Leu Gln Leu 
        355                 360                 365             


Ser Met Leu Glu Ile Val His Pro Gly Gln Val Glu Lys His Tyr Arg 
    370                 375                 380                 


Glu Met Glu Glu Lys Ser Ala Leu Ile Ile Gln Lys His Trp Arg Gly 
385                 390                 395                 400 


Tyr Arg Glu Arg Lys Asn Phe His Gln Gln Arg Gln Ser Leu Ile Glu 
                405                 410                 415     


Tyr Lys Ala Ala Val Thr Leu Gln Arg Ala Ala Leu Lys Phe Leu Ala 
            420                 425                 430         


Lys Cys Arg Lys Lys Lys Lys Leu Phe Ala Pro Trp Arg Gly Leu Gln 
        435                 440                 445             


Glu Leu Thr Asp Ala Arg Arg Val Glu Leu Lys Lys Arg Val Asp Asp 
    450                 455                 460                 


Tyr Val Arg Arg His Leu Gly Ser Pro Met Ser Asp Val Val Ser Arg 
465                 470                 475                 480 


Glu Leu His Ala Gln Ala Gln Glu Arg Leu Gln His Tyr Phe Met Gly 
                485                 490                 495     


Arg Ala Leu Glu Glu Arg Ala Gln Gln His Arg Glu Ala Leu Ile Ala 
            500                 505                 510         


Gln Ile Ser Thr Asn Val Glu Gln Leu Met Lys Ala Pro Ser Leu Lys 
        515                 520                 525             


Glu Ala Glu Gly Lys Glu Pro Glu Leu Phe Leu Ser Arg Ser Arg Pro 
    530                 535                 540                 


Val Ala Ala Lys Ala Lys Gln Ala His Leu Thr Thr Leu Lys His Ile 
545                 550                 555                 560 


Gln Ala Pro Trp Trp Lys Lys Leu Gly Glu Glu Ser Gly Asp Glu Ile 
                565                 570                 575     


Asp Val Pro Lys Asp Glu Leu Ser Ile Glu Leu Glu Asn Leu Phe Ile 
            580                 585                 590         


Gly Gly Thr Lys Pro Pro 
        595             


<210>  1484
<211>  963
<212>  PRT
<213>  homo sapiens

<400>  1484

Met Trp Cys Leu His Cys Asn Ser Glu Arg Thr Gln Ser Leu Leu Glu 
1               5                   10                  15      


Leu Glu Leu Asp Ser Gly Val Glu Gly Glu Ala Pro Ser Ser Glu Thr 
            20                  25                  30          


Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro Leu Val 
        35                  40                  45              


Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser Val Gly 
    50                  55                  60                  


Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg Thr Arg 
65                  70                  75                  80  


Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln Ala Glu 
                85                  90                  95      


Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr Glu Leu 
            100                 105                 110         


Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg Lys Tyr 
        115                 120                 125             


Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln Thr Ala 
    130                 135                 140                 


Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg Ser Ser 
145                 150                 155                 160 


Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn Met Arg 
                165                 170                 175     


Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser Tyr Phe 
            180                 185                 190         


Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu Gly Ala 
        195                 200                 205             


Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr Leu Lys 
    210                 215                 220                 


Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Asp 
                245                 250                 255     


Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala Leu Asp 
            260                 265                 270         


Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His Gly Met 
        275                 280                 285             


Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp Val Thr 
    290                 295                 300                 


Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu Ser Gln 
305                 310                 315                 320 


Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu Arg Ala 
                325                 330                 335     


Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu Asp Lys 
            340                 345                 350         


Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu Arg Gln 
        355                 360                 365             


Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile Glu Pro 
    370                 375                 380                 


Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg Gly Ser 
385                 390                 395                 400 


Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln Gln Gly 
                405                 410                 415     


Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu Pro Arg 
            420                 425                 430         


Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp Ser His 
        435                 440                 445             


Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu Ser Asp 
    450                 455                 460                 


Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn Ser Asn 
465                 470                 475                 480 


Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser Leu Arg 
                485                 490                 495     


Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg Asn Ser 
            500                 505                 510         


Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg His Tyr 
        515                 520                 525             


Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly Val Gln 
    530                 535                 540                 


Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly Val Ala 
545                 550                 555                 560 


His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly Glu 
                565                 570                 575     


Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu Asp Cys 
            580                 585                 590         


Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu Ala Leu 
        595                 600                 605             


Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys Val 
    610                 615                 620                 


Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys Asn Pro 
625                 630                 635                 640 


Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile Leu Ala 
                645                 650                 655     


Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Val Lys 
            660                 665                 670         


Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu Arg Gly 
        675                 680                 685             


Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly Ile Tyr 
    690                 695                 700                 


Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His Val Ser 
705                 710                 715                 720 


Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro Ile Gly 
                725                 730                 735     


Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His Arg Arg 
            740                 745                 750         


Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn Lys Pro 
        755                 760                 765             


Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn Asp Leu 
    770                 775                 780                 


Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val Thr Tyr 
785                 790                 795                 800 


Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu Leu Phe 
                805                 810                 815     


Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser Val Pro 
            820                 825                 830         


Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn Pro Gln 
        835                 840                 845             


Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala Glu Val 
    850                 855                 860                 


Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys Gln Lys 
865                 870                 875                 880 


Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys Lys Glu 
                885                 890                 895     


Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser Tyr Ala 
            900                 905                 910         


Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu Arg Asp 
        915                 920                 925             


Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly Ser Leu 
    930                 935                 940                 


Glu Ser Asn Val Glu Phe Gln Pro Phe Glu Pro Leu Gln Pro Ser Val 
945                 950                 955                 960 


Leu Cys Ser 
            


<210>  1485
<211>  381
<212>  PRT
<213>  homo sapiens

<400>  1485

Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys Gly Asn 
1               5                   10                  15      


Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr Asp Leu 
            20                  25                  30          


Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His Thr Thr 
        35                  40                  45              


Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp Leu Tyr 
    50                  55                  60                  


Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe Thr Cys 
65                  70                  75                  80  


Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln Glu His 
                85                  90                  95      


Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys Pro Ile 
            100                 105                 110         


Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe 
        115                 120                 125             


Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu 
    130                 135                 140                 


Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly Arg Gly 
145                 150                 155                 160 


Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser 
                165                 170                 175     


Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro Ser Asn 
            180                 185                 190         


Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu Ser Gly 
        195                 200                 205             


Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro Ser Ala 
    210                 215                 220                 


Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg Gln His 
225                 230                 235                 240 


Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala Thr Arg 
                245                 250                 255     


Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser Thr Ala 
            260                 265                 270         


Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu Gln Asn 
        275                 280                 285             


Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr 
    290                 295                 300                 


Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val 
305                 310                 315                 320 


Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser 
                325                 330                 335     


Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys 
            340                 345                 350         


Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys 
        355                 360                 365             


Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu 
    370                 375                 380     


<210>  1486
<211>  583
<212>  PRT
<213>  homo sapiens

<400>  1486

Met Thr Phe Tyr Leu Phe Gly Ile Arg Ser Phe Pro Lys Leu Trp Lys 
1               5                   10                  15      


Ser Pro Tyr Leu Gly Leu Gly Pro Gly His Ser Tyr Val Ser Leu Phe 
            20                  25                  30          


Leu Ala Asp Arg Cys Gly Ile Arg Asn Gln Gln Arg Leu Phe Ser Leu 
        35                  40                  45              


Lys Thr Met Ser Pro Gln Asn Thr Lys Ala Thr Asn Leu Ile Ala Lys 
    50                  55                  60                  


Ala Arg Tyr Leu Arg Lys Asp Glu Gly Ser Asn Lys Gln Val Tyr Ser 
65                  70                  75                  80  


Val Pro His Phe Phe Leu Ala Gly Ala Ala Lys Glu Arg Ser Gln Met 
                85                  90                  95      


Asn Ser Gln Thr Glu Asp His Ala Leu Ala Pro Val Arg Asn Thr Ile 
            100                 105                 110         


Gln Leu Pro Thr Gln Pro Leu Asn Ser Glu Glu Trp Asp Lys Leu Lys 
        115                 120                 125             


Glu Asp Leu Lys Glu Asn Thr Gly Lys Thr Ser Phe Glu Ser Trp Ile 
    130                 135                 140                 


Ile Ser Gln Met Ala Gly Cys His Ser Ser Ile Asp Val Ala Lys Ser 
145                 150                 155                 160 


Leu Leu Ala Trp Val Ala Ala Lys Asn Asn Gly Ile Val Ser Tyr Asp 
                165                 170                 175     


Leu Leu Val Lys Tyr Leu Tyr Leu Cys Val Phe His Met Gln Thr Ser 
            180                 185                 190         


Glu Val Ile Asp Val Phe Glu Ile Met Lys Ala Arg Tyr Lys Thr Leu 
        195                 200                 205             


Glu Pro Arg Gly Tyr Ser Leu Leu Ile Arg Gly Leu Ile His Ser Asp 
    210                 215                 220                 


Arg Trp Arg Glu Ala Leu Leu Leu Leu Glu Asp Ile Lys Lys Val Ile 
225                 230                 235                 240 


Thr Pro Ser Lys Lys Asn Tyr Asn Asp Cys Ile Gln Gly Ala Leu Leu 
                245                 250                 255     


His Gln Asp Val Asn Thr Ala Trp Asn Leu Tyr Gln Glu Leu Leu Gly 
            260                 265                 270         


His Asp Ile Val Pro Met Leu Glu Thr Leu Lys Ala Phe Phe Asp Phe 
        275                 280                 285             


Gly Lys Asp Ile Lys Asp Asp Asn Tyr Ser Asn Lys Leu Leu Asp Ile 
    290                 295                 300                 


Leu Ser Tyr Leu Arg Asn Asn Gln Leu Tyr Pro Gly Glu Ser Phe Ala 
305                 310                 315                 320 


His Ser Ile Lys Thr Trp Phe Glu Ser Val Pro Gly Lys Gln Trp Lys 
                325                 330                 335     


Gly Gln Phe Thr Thr Val Arg Lys Ser Gly Gln Cys Ser Gly Cys Gly 
            340                 345                 350         


Lys Thr Ile Glu Ser Ile Gln Leu Ser Pro Glu Glu Tyr Glu Cys Leu 
        355                 360                 365             


Lys Gly Lys Ile Met Arg Asp Val Ile Asp Gly Gly Asp Gln Tyr Arg 
    370                 375                 380                 


Lys Thr Thr Pro Gln Glu Leu Lys Arg Phe Glu Asn Phe Ile Lys Ser 
385                 390                 395                 400 


Arg Pro Pro Phe Asp Val Val Ile Asp Gly Leu Asn Val Ala Lys Met 
                405                 410                 415     


Phe Pro Lys Val Arg Glu Ser Gln Leu Leu Leu Asn Val Val Ser Gln 
            420                 425                 430         


Leu Ala Lys Arg Asn Leu Arg Leu Leu Val Leu Gly Arg Lys His Met 
        435                 440                 445             


Leu Arg Arg Ser Ser Gln Trp Ser Arg Asp Glu Met Glu Glu Val Gln 
    450                 455                 460                 


Lys Gln Ala Ser Cys Phe Phe Ala Asp Asp Ile Ser Glu Asp Asp Pro 
465                 470                 475                 480 


Phe Leu Leu Tyr Ala Thr Leu His Ser Gly Asn His Cys Arg Phe Ile 
                485                 490                 495     


Thr Arg Asp Leu Met Arg Asp His Lys Ala Cys Leu Pro Asp Ala Lys 
            500                 505                 510         


Thr Gln Arg Leu Phe Phe Lys Trp Gln Gln Gly His Gln Leu Ala Ile 
        515                 520                 525             


Val Asn Arg Phe Pro Gly Ser Lys Leu Thr Phe Gln Arg Ile Leu Ser 
    530                 535                 540                 


Tyr Asp Thr Val Val Gln Thr Thr Gly Asp Ser Trp His Ile Pro Tyr 
545                 550                 555                 560 


Asp Glu Asp Leu Val Glu Arg Cys Ser Cys Glu Val Pro Thr Lys Trp 
                565                 570                 575     


Leu Cys Leu His Gln Lys Thr 
            580             


<210>  1487
<211>  609
<212>  PRT
<213>  homo sapiens

<400>  1487

Met Glu Gly Lys Pro Met Arg Arg Cys Thr Asn Ile Arg Pro Gly Glu 
1               5                   10                  15      


Thr Gly Met Asp Val Thr Ser Arg Cys Thr Leu Gly Asp Pro Asn Lys 
            20                  25                  30          


Leu Pro Glu Gly Val Pro Gln Pro Ala Arg Met Pro Tyr Ile Ser Asp 
        35                  40                  45              


Lys His Pro Arg Gln Thr Leu Glu Val Ile Asn Leu Leu Arg Lys His 
    50                  55                  60                  


Arg Glu Leu Cys Asp Val Val Leu Val Val Gly Ala Lys Lys Ile Tyr 
65                  70                  75                  80  


Ala His Arg Val Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Ala Met 
                85                  90                  95      


Phe Thr Gly Glu Leu Ala Glu Ser Arg Gln Thr Glu Val Val Ile Arg 
            100                 105                 110         


Asp Ile Asp Glu Arg Ala Met Glu Leu Leu Ile Asp Phe Ala Tyr Thr 
        115                 120                 125             


Ser Gln Ile Thr Val Glu Glu Gly Asn Val Gln Thr Leu Leu Pro Ala 
    130                 135                 140                 


Ala Cys Leu Leu Gln Leu Ala Glu Ile Gln Glu Ala Cys Cys Glu Phe 
145                 150                 155                 160 


Leu Lys Arg Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
                165                 170                 175     


Ala Asp Thr His Ser Cys Arg Glu Leu Leu Arg Ile Ala Asp Lys Phe 
            180                 185                 190         


Thr Gln His Asn Phe Gln Glu Val Met Glu Ser Glu Glu Phe Met Leu 
        195                 200                 205             


Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp Glu Leu Asn 
    210                 215                 220                 


Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala Trp Val Lys 
225                 230                 235                 240 


Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val Leu Gln His 
                245                 250                 255     


Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly Thr Val Gly 
            260                 265                 270         


Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp Leu Val Asp 
        275                 280                 285             


Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro Leu Met Gln 
    290                 295                 300                 


Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly Glu Val Leu 
305                 310                 315                 320 


Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser Ser Val Glu 
                325                 330                 335     


Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala Ser Met Ser 
            340                 345                 350         


Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp Leu Leu Tyr 
        355                 360                 365             


Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser Val Glu Arg 
    370                 375                 380                 


Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala Pro Thr Ser 
385                 390                 395                 400 


Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly Phe Leu Tyr 
                405                 410                 415     


Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile Val Glu Arg 
            420                 425                 430         


Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser Met Ser Thr 
        435                 440                 445             


Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe Leu Tyr Ala 
    450                 455                 460                 


Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val Glu Arg Tyr 
465                 470                 475                 480 


Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met Gly Thr Arg 
                485                 490                 495     


Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile Tyr Ala Val 
            500                 505                 510         


Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu Arg Tyr Asn 
        515                 520                 525             


Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr Ser Arg Arg 
    530                 535                 540                 


Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met Ala Val Gly 
545                 550                 555                 560 


Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val Phe Asp Pro 
                565                 570                 575     


Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr Arg Arg Leu 
            580                 585                 590         


Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu Ser His Ile 
        595                 600                 605             


Trp 
    


<210>  1488
<211>  600
<212>  PRT
<213>  homo sapiens

<400>  1488

Met Val Leu Ile Leu Gly Arg Arg Leu Asn Arg Glu Asp Leu Gly Val 
1               5                   10                  15      


Arg Asp Ser Pro Ala Thr Lys Arg Lys Val Phe Glu Met Asp Pro Lys 
            20                  25                  30          


Ser Leu Thr Gly His Glu Phe Phe Asp Phe Ser Ser Gly Ser Ser His 
        35                  40                  45              


Ala Glu Asn Ile Leu Gln Ile Phe Asn Glu Phe Arg Asp Ser Arg Leu 
    50                  55                  60                  


Phe Thr Asp Val Ile Ile Cys Val Glu Gly Lys Glu Phe Pro Cys His 
65                  70                  75                  80  


Arg Ala Val Leu Ser Ala Cys Ser Ser Tyr Phe Arg Ala Met Phe Cys 
                85                  90                  95      


Asn Asp His Arg Glu Ser Arg Glu Met Leu Val Glu Ile Asn Gly Ile 
            100                 105                 110         


Leu Ala Glu Ala Met Glu Cys Phe Leu Gln Tyr Val Tyr Thr Gly Lys 
        115                 120                 125             


Val Lys Ile Thr Thr Glu Asn Val Gln Tyr Leu Phe Glu Thr Ser Ser 
    130                 135                 140                 


Leu Phe Gln Ile Ser Val Leu Arg Asp Ala Cys Ala Lys Phe Leu Glu 
145                 150                 155                 160 


Glu Gln Leu Asp Pro Cys Asn Cys Leu Gly Ile Gln Arg Phe Ala Asp 
                165                 170                 175     


Thr His Ser Leu Lys Thr Leu Phe Thr Lys Cys Lys Asn Phe Ala Leu 
            180                 185                 190         


Gln Thr Phe Glu Asp Val Ser Gln His Glu Glu Phe Leu Glu Leu Asp 
        195                 200                 205             


Lys Asp Glu Leu Ile Asp Tyr Ile Cys Ser Asp Glu Leu Val Ile Gly 
    210                 215                 220                 


Lys Glu Glu Met Val Phe Glu Ala Val Met Arg Trp Val Tyr Arg Ala 
225                 230                 235                 240 


Val Asp Leu Arg Arg Pro Leu Leu His Glu Leu Leu Thr His Val Arg 
                245                 250                 255     


Leu Pro Leu Leu His Pro Asn Tyr Phe Val Gln Thr Val Glu Val Asp 
            260                 265                 270         


Gln Leu Ile Gln Asn Ser Pro Glu Cys Tyr Gln Leu Leu His Glu Ala 
        275                 280                 285             


Arg Arg Tyr His Ile Leu Gly Asn Glu Met Met Ser Pro Arg Thr Arg 
    290                 295                 300                 


Pro Arg Arg Ser Thr Gly Tyr Ser Glu Val Ile Val Val Val Gly Gly 
305                 310                 315                 320 


Cys Glu Arg Val Gly Gly Phe Asn Leu Pro Tyr Thr Glu Cys Tyr Asp 
                325                 330                 335     


Pro Val Thr Gly Glu Trp Lys Ser Leu Ala Lys Leu Pro Glu Phe Thr 
            340                 345                 350         


Lys Ser Glu Tyr Ala Val Cys Ala Leu Arg Asn Asp Ile Leu Val Ser 
        355                 360                 365             


Gly Gly Arg Ile Asn Ser Arg Asp Val Trp Ile Tyr Asn Ser Gln Leu 
    370                 375                 380                 


Asn Ile Trp Ile Arg Val Ala Ser Leu Asn Lys Gly Arg Trp Arg His 
385                 390                 395                 400 


Lys Met Ala Val Leu Leu Gly Lys Val Tyr Val Val Gly Gly Tyr Asp 
                405                 410                 415     


Gly Gln Asn Arg Leu Ser Ser Val Glu Cys Tyr Asp Ser Phe Ser Asn 
            420                 425                 430         


Arg Trp Thr Glu Val Ala Pro Leu Lys Glu Ala Val Ser Ser Pro Ala 
        435                 440                 445             


Val Thr Ser Cys Val Gly Lys Leu Phe Val Ile Gly Gly Gly Pro Asp 
    450                 455                 460                 


Asp Asn Thr Cys Ser Asp Lys Val Gln Ser Tyr Asp Pro Glu Thr Asn 
465                 470                 475                 480 


Ser Trp Leu Leu Arg Ala Ala Ile Pro Ile Ala Lys Arg Cys Ile Thr 
                485                 490                 495     


Ala Val Ser Leu Asn Asn Leu Ile Tyr Val Ala Gly Gly Leu Thr Lys 
            500                 505                 510         


Ala Ile Tyr Cys Tyr Asp Pro Val Glu Asp Tyr Trp Met His Val Gln 
        515                 520                 525             


Asn Thr Phe Ser Arg Gln Glu Asn Cys Gly Met Ser Val Cys Asn Gly 
    530                 535                 540                 


Lys Ile Tyr Ile Leu Gly Gly Arg Arg Glu Asn Gly Glu Ala Thr Asp 
545                 550                 555                 560 


Thr Ile Leu Cys Tyr Asp Pro Ala Thr Ser Ile Ile Thr Gly Val Ala 
                565                 570                 575     


Ala Met Pro Arg Pro Val Ser Tyr His Gly Cys Val Thr Ile His Arg 
            580                 585                 590         


Tyr Asn Glu Lys Cys Phe Lys Leu 
        595                 600 


<210>  1489
<211>  736
<212>  PRT
<213>  homo sapiens

<400>  1489

Met Gly Asn Pro Glu Asn Ile Glu Asp Ala Tyr Val Ala Val Ile Arg 
1               5                   10                  15      


Pro Lys Asn Thr Ala Ser Leu Asn Ser Arg Glu Tyr Arg Ala Lys Ser 
            20                  25                  30          


Tyr Glu Ile Leu Leu His Glu Val Pro Ile Glu Gly Gln Lys Lys Lys 
        35                  40                  45              


Arg Lys Lys Val Leu Leu Glu Thr Lys Leu Gln Gly Asn Ser Glu Ile 
    50                  55                  60                  


Thr Gln Gly Ile Leu Asp Tyr Val Val Glu Thr Thr Lys Pro Ile Ser 
65                  70                  75                  80  


Pro Ala Asn Gln Gly Ile Arg Gly Lys Arg Val Val Leu Met Lys Lys 
                85                  90                  95      


Phe Pro Leu Asp Gly Glu Lys Met Gly Arg Glu Ala Ser Leu Phe Ile 
            100                 105                 110         


Val Pro Ser Val Val Lys Asp Asn Thr Lys Tyr Thr Tyr Thr Pro Gly 
        115                 120                 125             


Cys Pro Ile Phe Tyr Cys Leu Gln Asp Ile Met Arg Val Cys Ser Glu 
    130                 135                 140                 


Ser Ser Thr His Phe Ala Thr Leu Thr Ala Arg Met Leu Ile Ala Leu 
145                 150                 155                 160 


Asp Lys Trp Leu Asp Glu Arg His Ala Gln Ser His Phe Ile Pro Ala 
                165                 170                 175     


Leu Phe Arg Pro Ser Pro Leu Glu Arg Ile Lys Thr Asn Val Ile Asn 
            180                 185                 190         


Pro Ala Tyr Ala Thr Glu Ser Gly Gln Thr Glu Asn Ser Leu His Met 
        195                 200                 205             


Gly Tyr Ser Ala Leu Glu Ile Lys Ser Lys Met Leu Ala Leu Glu Lys 
    210                 215                 220                 


Ala Asp Thr Cys Ile Tyr Asn Pro Leu Phe Gly Ser Asp Leu Gln Tyr 
225                 230                 235                 240 


Thr Asn Arg Val Asp Lys Val Val Ile Asn Pro Tyr Phe Gly Leu Gly 
                245                 250                 255     


Ala Pro Asp Tyr Ser Lys Ile Gln Ile Pro Lys Gln Glu Lys Trp Gln 
            260                 265                 270         


Arg Ser Met Ser Ser Val Thr Glu Asp Lys Glu Arg Gln Trp Val Asp 
        275                 280                 285             


Asp Phe Pro Leu His Arg Ser Ala Cys Glu Gly Asp Ser Glu Leu Leu 
    290                 295                 300                 


Ser Arg Leu Leu Ser Glu Arg Phe Ser Val Asn Gln Leu Asp Ser Asp 
305                 310                 315                 320 


His Trp Ala Pro Ile His Tyr Ala Cys Trp Tyr Gly Lys Val Glu Ala 
                325                 330                 335     


Thr Arg Ile Leu Leu Glu Lys Gly Lys Cys Asn Pro Asn Leu Leu Asn 
            340                 345                 350         


Gly Gln Leu Ser Ser Pro Leu His Phe Ala Ala Gly Gly Gly His Ala 
        355                 360                 365             


Glu Ile Val Gln Ile Leu Leu Asn His Pro Glu Thr Asp Arg His Ile 
    370                 375                 380                 


Thr Asp Gln Gln Gly Arg Ser Pro Leu Asn Ile Cys Glu Glu Asn Lys 
385                 390                 395                 400 


Gln Asn Asn Trp Glu Glu Ala Ala Lys Leu Leu Lys Glu Ala Ile Asn 
                405                 410                 415     


Lys Pro Tyr Glu Lys Val Arg Ile Tyr Arg Met Asp Gly Ser Tyr Arg 
            420                 425                 430         


Ser Val Glu Leu Lys His Gly Asn Asn Thr Thr Val Gln Gln Ile Met 
        435                 440                 445             


Glu Gly Met Arg Leu Ser Gln Glu Thr Gln Gln Tyr Phe Thr Ile Trp 
    450                 455                 460                 


Ile Cys Ser Glu Asn Leu Ser Leu Gln Leu Lys Pro Tyr His Lys Pro 
465                 470                 475                 480 


Leu Gln His Val Arg Asp Trp Pro Glu Ile Leu Ala Glu Leu Thr Asn 
                485                 490                 495     


Leu Asp Pro Gln Arg Glu Thr Pro Gln Leu Phe Leu Arg Arg Asp Val 
            500                 505                 510         


Arg Leu Pro Leu Glu Val Glu Lys Gln Ile Glu Asp Pro Leu Ala Ile 
        515                 520                 525             


Leu Ile Leu Phe Asp Glu Ala Arg Tyr Asn Leu Leu Lys Gly Phe Tyr 
    530                 535                 540                 


Thr Ala Pro Asp Ala Lys Leu Ile Thr Leu Ala Ser Leu Leu Leu Gln 
545                 550                 555                 560 


Ile Val Tyr Gly Asn Tyr Glu Ser Lys Lys His Lys Gln Gly Phe Leu 
                565                 570                 575     


Asn Glu Glu Asn Leu Lys Ser Ile Val Pro Val Thr Lys Leu Lys Ser 
            580                 585                 590         


Lys Ala Pro His Trp Thr Asn Arg Ile Leu His Glu Tyr Lys Asn Leu 
        595                 600                 605             


Ser Thr Ser Glu Gly Val Ser Lys Glu Met His His Leu Gln Arg Met 
    610                 615                 620                 


Phe Leu Gln Asn Cys Trp Glu Ile Pro Thr Tyr Gly Ala Ala Phe Phe 
625                 630                 635                 640 


Thr Gly Gln Ile Phe Thr Lys Ala Ser Pro Ser Asn His Lys Val Ile 
                645                 650                 655     


Pro Val Tyr Val Gly Val Asn Ile Lys Gly Leu His Leu Leu Asn Met 
            660                 665                 670         


Glu Thr Lys Ala Leu Leu Ile Ser Leu Lys Tyr Gly Cys Phe Met Trp 
        675                 680                 685             


Gln Leu Gly Asp Thr Asp Thr Cys Phe Gln Ile His Ser Met Glu Asn 
    690                 695                 700                 


Lys Met Ser Phe Ile Val His Thr Lys Gln Ala Gly Leu Val Val Lys 
705                 710                 715                 720 


Leu Leu Met Lys Leu Asn Gly Gln Leu Met Pro Thr Glu Arg Asn Ser 
                725                 730                 735     


<210>  1490
<211>  399
<212>  PRT
<213>  homo sapiens

<400>  1490

Met Ala Gln Arg Ala Phe Pro Asn Pro Tyr Ala Asp Tyr Asn Lys Ser 
1               5                   10                  15      


Leu Ala Glu Gly Tyr Phe Asp Ala Ala Gly Arg Leu Thr Pro Glu Phe 
            20                  25                  30          


Ser Gln Arg Leu Thr Asn Lys Ile Arg Glu Leu Leu Gln Gln Met Glu 
        35                  40                  45              


Arg Gly Leu Lys Ser Ala Asp Pro Arg Asp Gly Thr Gly Tyr Thr Gly 
    50                  55                  60                  


Trp Ala Gly Ile Ala Val Leu Tyr Leu His Leu Tyr Asp Val Phe Gly 
65                  70                  75                  80  


Asp Pro Ala Tyr Leu Gln Leu Ala His Gly Tyr Val Lys Gln Ser Leu 
                85                  90                  95      


Asn Cys Leu Thr Lys Arg Ser Ile Thr Phe Leu Cys Gly Asp Ala Gly 
            100                 105                 110         


Pro Leu Ala Val Ala Ala Val Leu Tyr His Lys Met Asn Asn Glu Lys 
        115                 120                 125             


Gln Ala Glu Asp Cys Ile Thr Arg Leu Ile His Leu Asn Lys Ile Asp 
    130                 135                 140                 


Pro His Ala Pro Asn Glu Met Leu Tyr Gly Arg Ile Gly Tyr Ile Tyr 
145                 150                 155                 160 


Ala Leu Leu Phe Val Asn Lys Asn Phe Gly Val Glu Lys Ile Pro Gln 
                165                 170                 175     


Ser His Ile Gln Gln Ile Cys Glu Thr Ile Leu Thr Ser Gly Glu Asn 
            180                 185                 190         


Leu Ala Arg Lys Arg Asn Phe Thr Ala Lys Ser Pro Leu Met Tyr Glu 
        195                 200                 205             


Trp Tyr Gln Glu Tyr Tyr Val Gly Ala Ala His Gly Leu Ala Gly Ile 
    210                 215                 220                 


Tyr Tyr Tyr Leu Met Gln Pro Ser Leu Gln Val Ser Gln Gly Lys Leu 
225                 230                 235                 240 


His Ser Leu Val Lys Pro Ser Val Asp Tyr Val Cys Gln Leu Lys Phe 
                245                 250                 255     


Pro Ser Gly Asn Tyr Pro Pro Cys Ile Gly Asp Asn Arg Asp Leu Leu 
            260                 265                 270         


Val His Trp Cys His Gly Ala Pro Gly Val Ile Tyr Met Leu Ile Gln 
        275                 280                 285             


Ala Tyr Lys Val Phe Arg Glu Glu Lys Tyr Leu Cys Asp Ala Tyr Gln 
    290                 295                 300                 


Cys Ala Asp Val Ile Trp Gln Tyr Gly Leu Leu Lys Lys Gly Tyr Gly 
305                 310                 315                 320 


Leu Cys His Gly Ser Ala Gly Asn Ala Tyr Ala Phe Leu Thr Leu Tyr 
                325                 330                 335     


Asn Leu Thr Gln Asp Met Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala 
            340                 345                 350         


Glu Trp Cys Leu Glu Tyr Gly Glu His Gly Cys Arg Thr Pro Asp Thr 
        355                 360                 365             


Pro Phe Ser Leu Phe Glu Gly Met Ala Gly Thr Ile Tyr Phe Leu Ala 
    370                 375                 380                 


Asp Leu Leu Val Pro Thr Lys Ala Arg Phe Pro Ala Phe Glu Leu 
385                 390                 395                 


<210>  1491
<211>  1019
<212>  PRT
<213>  homo sapiens

<400>  1491

Met Leu Trp Arg Val Leu Leu Ser Lys Arg Pro Pro Phe Pro His Pro 
1               5                   10                  15      


Glu Leu Asp Phe Gln Glu Ala Pro Ile Pro Ser Cys Pro Gly Arg Leu 
            20                  25                  30          


Pro Gly Arg Lys Asn Ser Val Ala Leu Ala Ala Ala Pro Arg Lys Glu 
        35                  40                  45              


Pro Thr Gly Asp Arg Glu Lys Pro Leu Pro Phe Pro Val Leu Ala Pro 
    50                  55                  60                  


Phe Ser Asn Pro Glu His Ser Ala Pro Ala Lys Val Val Arg Ala Ala 
65                  70                  75                  80  


Val Pro Lys Gln Arg Lys Gly Ser Lys Val Gly Asp Phe Gly Asp Ala 
                85                  90                  95      


Ile Asn Trp Pro Thr Pro Gly Glu Ile Ala His Lys Ser Val Gln Pro 
            100                 105                 110         


Gln Ser His Lys Pro Gln Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp 
        115                 120                 125             


Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
    130                 135                 140                 


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
145                 150                 155                 160 


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
                165                 170                 175     


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
            180                 185                 190         


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
        195                 200                 205             


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
    210                 215                 220                 


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
225                 230                 235                 240 


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
                245                 250                 255     


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
            260                 265                 270         


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
        275                 280                 285             


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
    290                 295                 300                 


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
305                 310                 315                 320 


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
                325                 330                 335     


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
            340                 345                 350         


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
        355                 360                 365             


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
    370                 375                 380                 


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
385                 390                 395                 400 


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
                405                 410                 415     


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
            420                 425                 430         


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
        435                 440                 445             


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
    450                 455                 460                 


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
465                 470                 475                 480 


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
                485                 490                 495     


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
            500                 505                 510         


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
        515                 520                 525             


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
    530                 535                 540                 


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
545                 550                 555                 560 


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
                565                 570                 575     


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
            580                 585                 590         


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
        595                 600                 605             


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
    610                 615                 620                 


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
625                 630                 635                 640 


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
                645                 650                 655     


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
            660                 665                 670         


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
        675                 680                 685             


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
    690                 695                 700                 


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
705                 710                 715                 720 


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
                725                 730                 735     


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
            740                 745                 750         


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
        755                 760                 765             


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
    770                 775                 780                 


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
785                 790                 795                 800 


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
                805                 810                 815     


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
            820                 825                 830         


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
        835                 840                 845             


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
    850                 855                 860                 


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
865                 870                 875                 880 


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
                885                 890                 895     


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
            900                 905                 910         


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
        915                 920                 925             


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
    930                 935                 940                 


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
945                 950                 955                 960 


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
                965                 970                 975     


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
            980                 985                 990         


Pro Thr Pro Pro Thr Gly Gln Pro  Val Arg Glu Asp Ala  Lys Trp Thr 
        995                 1000                 1005             


Ser Gln  His Ser Asn Thr Gln  Thr Leu Gly Lys 
    1010                 1015                 


<210>  1492
<211>  724
<212>  PRT
<213>  homo sapiens

<400>  1492

Met Leu Leu Phe Val Glu Gln Val Ala Ser Lys Gly Thr Gly Leu Asn 
1               5                   10                  15      


Pro Asn Ala Lys Val Trp Gln Glu Ile Ala Pro Gly Asn Thr Asp Ala 
            20                  25                  30          


Thr Pro Val Thr His Gly Thr Glu Ser Ser Trp His Glu Ile Ala Ala 
        35                  40                  45              


Thr Ser Gly Ala His Pro Glu Gly Asn Ala Glu Leu Ser Glu Asp Ile 
    50                  55                  60                  


Cys Lys Glu Tyr Glu Val Met Tyr Ser Ser Ser Cys Glu Thr Thr Arg 
65                  70                  75                  80  


Asn Thr Thr Gly Ile Glu Glu Ser Thr Asp Gly Met Ile Leu Gly Pro 
                85                  90                  95      


Glu Asp Leu Ser Tyr Gln Ile Tyr Asp Val Ser Gly Glu Ser Asn Ser 
            100                 105                 110         


Ala Val Ser Thr Glu Asp Leu Lys Glu Cys Leu Lys Lys Gln Leu Glu 
        115                 120                 125             


Phe Cys Phe Ser Arg Glu Asn Leu Ser Lys Asp Leu Tyr Leu Ile Ser 
    130                 135                 140                 


Gln Met Asp Ser Asp Gln Phe Ile Pro Ile Trp Thr Val Ala Asn Met 
145                 150                 155                 160 


Glu Glu Ile Lys Lys Leu Thr Thr Asp Pro Asp Leu Ile Leu Glu Val 
                165                 170                 175     


Leu Arg Ser Ser Pro Met Val Gln Val Asp Glu Lys Gly Glu Lys Val 
            180                 185                 190         


Arg Pro Ser His Lys Arg Cys Ile Val Ile Leu Arg Glu Ile Pro Glu 
        195                 200                 205             


Thr Thr Pro Ile Glu Glu Val Lys Gly Leu Phe Lys Ser Glu Asn Cys 
    210                 215                 220                 


Pro Lys Val Ile Ser Cys Glu Phe Ala His Asn Ser Asn Trp Tyr Ile 
225                 230                 235                 240 


Thr Phe Gln Ser Asp Thr Asp Ala Gln Gln Ala Phe Lys Tyr Leu Arg 
                245                 250                 255     


Glu Glu Val Lys Thr Phe Gln Gly Lys Pro Ile Met Ala Arg Ile Lys 
            260                 265                 270         


Ala Ile Asn Thr Phe Phe Ala Lys Asn Gly Tyr Arg Leu Met Asp Ser 
        275                 280                 285             


Ser Ile Tyr Ser His Pro Ile Gln Thr Gln Ala Gln Tyr Ala Ser Pro 
    290                 295                 300                 


Val Phe Met Gln Pro Val Tyr Asn Pro His Gln Gln Tyr Ser Val Tyr 
305                 310                 315                 320 


Ser Ile Val Pro Gln Ser Trp Ser Pro Asn Pro Thr Pro Tyr Phe Glu 
                325                 330                 335     


Thr Pro Leu Ala Pro Phe Pro Asn Gly Ser Phe Val Asn Gly Phe Asn 
            340                 345                 350         


Ser Pro Gly Ser Tyr Lys Thr Asn Ala Ala Ala Met Asn Met Gly Arg 
        355                 360                 365             


Pro Phe Gln Lys Asn Arg Val Lys Pro Gln Phe Arg Ser Ser Gly Gly 
    370                 375                 380                 


Ser Glu His Ser Thr Glu Gly Ser Val Ser Leu Gly Asp Gly Gln Leu 
385                 390                 395                 400 


Asn Arg Tyr Ser Ser Arg Asn Phe Pro Ala Glu Arg His Asn Pro Thr 
                405                 410                 415     


Val Thr Gly His Gln Glu Gln Thr Tyr Leu Gln Lys Glu Thr Ser Thr 
            420                 425                 430         


Leu Gln Val Glu Gln Asn Gly Asp Tyr Gly Arg Gly Arg Arg Thr Leu 
        435                 440                 445             


Phe Arg Gly Arg Arg Arg Arg Glu Asp Asp Arg Ile Ser Arg Pro His 
    450                 455                 460                 


Pro Ser Thr Ala Glu Ser Lys Ala Pro Thr Pro Lys Phe Asp Leu Leu 
465                 470                 475                 480 


Ala Ser Asn Phe Pro Pro Leu Pro Gly Ser Ser Ser Arg Met Pro Gly 
                485                 490                 495     


Glu Leu Val Leu Glu Asn Arg Met Ser Asp Val Val Lys Gly Val Tyr 
            500                 505                 510         


Lys Glu Lys Asp Asn Glu Glu Leu Thr Ile Ser Cys Pro Val Pro Ala 
        515                 520                 525             


Asp Glu Gln Thr Glu Cys Thr Ser Ala Gln Gln Leu Asn Met Ser Thr 
    530                 535                 540                 


Ser Ser Pro Cys Ala Ala Glu Leu Thr Ala Leu Ser Thr Thr Gln Gln 
545                 550                 555                 560 


Glu Lys Asp Leu Ile Glu Asp Ser Ser Val Gln Lys Asp Gly Leu Asn 
                565                 570                 575     


Gln Thr Thr Ile Pro Val Ser Pro Pro Ser Thr Thr Lys Pro Ser Arg 
            580                 585                 590         


Ala Ser Thr Ala Ser Pro Cys Asn Asn Asn Ile Asn Ala Ala Thr Ala 
        595                 600                 605             


Val Ala Leu Gln Glu Pro Arg Lys Leu Ser Tyr Ala Glu Val Cys Gln 
    610                 615                 620                 


Lys Pro Pro Lys Glu Pro Ser Ser Val Leu Val Gln Pro Leu Arg Glu 
625                 630                 635                 640 


Leu Arg Ser Asn Val Val Ser Pro Thr Lys Asn Glu Asp Asn Gly Ala 
                645                 650                 655     


Pro Glu Asn Ser Val Glu Lys Pro His Glu Lys Pro Glu Ala Arg Ala 
            660                 665                 670         


Ser Lys Asp Tyr Ser Gly Phe Arg Gly Asn Ile Ile Pro Arg Gly Ala 
        675                 680                 685             


Ala Gly Lys Ile Arg Glu Gln Arg Arg Gln Phe Ser His Arg Ala Ile 
    690                 695                 700                 


Pro Gln Gly Val Thr Arg Arg Asn Gly Lys Glu Gln Tyr Val Pro Pro 
705                 710                 715                 720 


Arg Ser Pro Lys 
                


<210>  1493
<211>  858
<212>  PRT
<213>  homo sapiens

<400>  1493

Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala 
            20                  25                  30          


Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr 
        35                  40                  45              


Lys Asp Gln Val Val Cys Leu Pro Val Leu Pro Ser Pro Val Asn Ser 
    50                  55                  60                  


Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro 
65                  70                  75                  80  


Lys Met Glu Ala Ala Thr Asn Gln Asp Gln Asp Gly Arg Thr Thr Asn 
                85                  90                  95      


Asp Ile Ser Phe Gly Thr Ser Ala Val Thr Pro Asp Ile Pro Leu Arg 
            100                 105                 110         


Ala Thr Tyr Pro Arg Thr Asp Phe Ala Leu Pro Asn Gln Glu Ala Lys 
        115                 120                 125             


Lys Glu Lys Lys Asp Pro Thr Gly Arg Lys Thr Asn Leu Asp Phe Gln 
    130                 135                 140                 


Gln Tyr Val Phe Ile Asn Gln Met Cys Tyr His Leu Ala Leu Pro Trp 
145                 150                 155                 160 


Tyr Ser Lys Tyr Phe Pro Tyr Leu Ala Leu Ile His Thr Ile Ile Leu 
                165                 170                 175     


Met Val Ser Ser Asn Phe Trp Phe Lys Tyr Pro Lys Thr Cys Ser Lys 
            180                 185                 190         


Val Glu His Phe Val Ser Ile Leu Gly Lys Cys Phe Glu Ser Pro Trp 
        195                 200                 205             


Thr Thr Lys Ala Leu Ser Glu Thr Ala Cys Glu Asp Ser Glu Glu Asn 
    210                 215                 220                 


Lys Gln Arg Ile Thr Gly Ala Gln Thr Leu Pro Lys His Val Ser Thr 
225                 230                 235                 240 


Ser Ser Asp Glu Gly Ser Pro Ser Ala Ser Thr Pro Met Ile Asn Lys 
                245                 250                 255     


Thr Gly Phe Lys Phe Ser Ala Glu Lys Pro Val Ile Glu Val Pro Ser 
            260                 265                 270         


Met Thr Ile Leu Asp Lys Lys Asp Gly Glu Gln Ala Lys Ala Leu Phe 
        275                 280                 285             


Glu Lys Val Arg Lys Phe Arg Ala His Val Glu Asp Ser Asp Leu Ile 
    290                 295                 300                 


Tyr Lys Leu Tyr Val Val Gln Thr Val Ile Lys Thr Ala Lys Phe Ile 
305                 310                 315                 320 


Phe Ile Leu Cys Tyr Thr Ala Asn Phe Val Asn Ala Ile Ser Phe Glu 
                325                 330                 335     


His Val Cys Lys Pro Lys Val Glu His Leu Ile Gly Tyr Glu Val Phe 
            340                 345                 350         


Glu Cys Thr His Asn Met Ala Tyr Met Leu Lys Lys Leu Leu Ile Ser 
        355                 360                 365             


Tyr Ile Ser Ile Ile Cys Val Tyr Gly Phe Ile Cys Leu Tyr Thr Leu 
    370                 375                 380                 


Phe Trp Leu Phe Arg Ile Pro Leu Lys Glu Tyr Ser Phe Glu Lys Val 
385                 390                 395                 400 


Arg Glu Glu Ser Ser Phe Ser Asp Ile Pro Asp Val Lys Asn Asp Phe 
                405                 410                 415     


Ala Phe Leu Leu His Met Val Asp Gln Tyr Asp Gln Leu Tyr Ser Lys 
            420                 425                 430         


Arg Phe Gly Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Glu 
        435                 440                 445             


Ile Ser Leu Asn His Glu Trp Thr Phe Glu Lys Leu Arg Gln His Ile 
    450                 455                 460                 


Ser Arg Asn Ala Gln Asp Lys Gln Glu Leu His Leu Phe Met Leu Ser 
465                 470                 475                 480 


Gly Val Pro Asp Ala Val Phe Asp Leu Thr Asp Leu Asp Val Leu Lys 
                485                 490                 495     


Leu Glu Leu Ile Pro Glu Ala Lys Ile Pro Ala Lys Ile Ser Gln Met 
            500                 505                 510         


Thr Asn Leu Gln Glu Leu His Leu Cys His Cys Pro Ala Lys Val Glu 
        515                 520                 525             


Gln Thr Ala Phe Ser Phe Leu Arg Asp His Leu Arg Cys Leu His Val 
    530                 535                 540                 


Lys Phe Thr Asp Val Ala Glu Ile Pro Ala Trp Val Tyr Leu Leu Lys 
545                 550                 555                 560 


Asn Leu Arg Glu Leu Tyr Leu Ile Gly Asn Leu Asn Ser Glu Asn Asn 
                565                 570                 575     


Lys Met Ile Gly Leu Glu Ser Leu Arg Glu Leu Arg His Leu Lys Ile 
            580                 585                 590         


Leu His Val Lys Ser Asn Leu Thr Lys Val Pro Ser Asn Ile Thr Asp 
        595                 600                 605             


Val Ala Pro His Leu Thr Lys Leu Val Ile His Asn Asp Gly Thr Lys 
    610                 615                 620                 


Leu Leu Val Leu Asn Ser Leu Lys Lys Met Met Asn Val Ala Glu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Cys Glu Leu Glu Arg Ile Pro His Ala Ile Phe Ser 
                645                 650                 655     


Leu Ser Asn Leu Gln Glu Leu Asp Leu Lys Ser Asn Asn Ile Arg Thr 
            660                 665                 670         


Ile Glu Glu Ile Ile Ser Phe Gln His Leu Lys Arg Leu Thr Cys Leu 
        675                 680                 685             


Lys Leu Trp His Asn Lys Ile Val Thr Ile Pro Pro Ser Ile Thr His 
    690                 695                 700                 


Val Lys Asn Leu Glu Ser Leu Tyr Phe Ser Asn Asn Lys Leu Glu Ser 
705                 710                 715                 720 


Leu Pro Val Ala Val Phe Ser Leu Gln Lys Leu Arg Cys Leu Asp Val 
                725                 730                 735     


Ser Tyr Asn Asn Ile Ser Met Ile Pro Ile Glu Ile Gly Leu Leu Gln 
            740                 745                 750         


Asn Leu Gln His Leu His Ile Thr Gly Asn Lys Val Asp Ile Leu Pro 
        755                 760                 765             


Lys Gln Leu Phe Lys Cys Ile Lys Leu Arg Thr Leu Asn Leu Gly Gln 
    770                 775                 780                 


Asn Cys Ile Thr Ser Leu Pro Glu Lys Val Gly Gln Leu Ser Gln Leu 
785                 790                 795                 800 


Thr Gln Leu Glu Leu Lys Gly Asn Cys Leu Asp Arg Leu Pro Ala Gln 
                805                 810                 815     


Leu Gly Gln Cys Arg Met Leu Lys Lys Ser Gly Leu Val Val Glu Asp 
            820                 825                 830         


His Leu Phe Asp Thr Leu Pro Leu Glu Val Lys Glu Ala Leu Asn Gln 
        835                 840                 845             


Asp Ile Asn Ile Pro Phe Ala Asn Gly Ile 
    850                 855             


<210>  1494
<211>  5430
<212>  PRT
<213>  homo sapiens

<400>  1494

Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210>  1495
<211>  462
<212>  PRT
<213>  homo sapiens

<400>  1495

Met Ala Lys Phe Arg Arg Arg Thr Cys Ile Ile Leu Ala Leu Phe Ile 
1               5                   10                  15      


Leu Phe Ile Phe Ser Leu Met Met Gly Leu Lys Met Leu Arg Pro Asn 
            20                  25                  30          


Thr Ala Thr Phe Gly Ala Pro Phe Gly Leu Asp Leu Leu Pro Glu Leu 
        35                  40                  45              


His Gln Arg Thr Ile His Leu Gly Lys Asn Phe Asp Phe Gln Lys Ser 
    50                  55                  60                  


Asp Arg Ile Asn Ser Glu Thr Asn Thr Lys Asn Leu Lys Ser Val Glu 
65                  70                  75                  80  


Ile Thr Met Lys Pro Ser Lys Ala Ser Glu Leu Asn Leu Asp Glu Leu 
                85                  90                  95      


Pro Pro Leu Asn Asn Tyr Leu His Val Phe Tyr Tyr Ser Trp Tyr Gly 
            100                 105                 110         


Asn Pro Gln Phe Asp Gly Lys Tyr Ile His Trp Asn His Pro Val Leu 
        115                 120                 125             


Glu His Trp Asp Pro Arg Ile Ala Lys Asn Tyr Pro Gln Gly Arg His 
    130                 135                 140                 


Asn Pro Pro Asp Asp Ile Gly Ser Ser Phe Tyr Pro Glu Leu Gly Ser 
145                 150                 155                 160 


Tyr Ser Ser Arg Asp Pro Ser Val Ile Glu Thr His Met Arg Gln Met 
                165                 170                 175     


Arg Ser Ala Ser Ile Gly Val Leu Ala Leu Ser Trp Tyr Pro Pro Asp 
            180                 185                 190         


Val Asn Asp Glu Asn Gly Glu Pro Thr Asp Asn Leu Val Pro Thr Ile 
        195                 200                 205             


Leu Asp Lys Ala His Lys Tyr Asn Leu Lys Val Thr Phe His Ile Glu 
    210                 215                 220                 


Pro Tyr Ser Asn Arg Asp Asp Gln Asn Met Tyr Lys Asn Val Lys Tyr 
225                 230                 235                 240 


Ile Ile Asp Lys Tyr Gly Asn His Pro Ala Phe Tyr Arg Tyr Lys Thr 
                245                 250                 255     


Lys Thr Gly Asn Ala Leu Pro Met Phe Tyr Val Tyr Asp Ser Tyr Ile 
            260                 265                 270         


Thr Lys Pro Glu Lys Trp Ala Asn Leu Leu Thr Thr Ser Gly Ser Arg 
        275                 280                 285             


Ser Ile Arg Asn Ser Pro Tyr Asp Gly Leu Phe Ile Ala Leu Leu Val 
    290                 295                 300                 


Glu Glu Lys His Lys Tyr Asp Ile Leu Gln Ser Gly Phe Asp Gly Ile 
305                 310                 315                 320 


Tyr Thr Tyr Phe Ala Thr Asn Gly Phe Thr Tyr Gly Ser Ser His Gln 
                325                 330                 335     


Asn Trp Ala Ser Leu Lys Leu Phe Cys Asp Lys Tyr Asn Leu Ile Phe 
            340                 345                 350         


Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp 
        355                 360                 365             


Asn Thr Gln Asn Thr Arg Asn Arg Ile Asn Gly Lys Tyr Tyr Glu Ile 
    370                 375                 380                 


Gly Leu Ser Ala Ala Leu Gln Thr Arg Pro Ser Leu Ile Ser Ile Thr 
385                 390                 395                 400 


Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Val Pro 
                405                 410                 415     


Lys Arg Thr Ser Asn Thr Val Tyr Leu Asp Tyr Arg Pro His Lys Pro 
            420                 425                 430         


Gly Leu Tyr Leu Glu Leu Thr Arg Lys Trp Ser Glu Lys Tyr Ser Lys 
        435                 440                 445             


Glu Arg Ala Thr Tyr Ala Leu Asp Arg Gln Leu Pro Val Ser 
    450                 455                 460         


<210>  1496
<211>  334
<212>  PRT
<213>  homo sapiens

<400>  1496

Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile 
1               5                   10                  15      


Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys 
            20                  25                  30          


Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly 
        35                  40                  45              


Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu 
    50                  55                  60                  


Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp 
65                  70                  75                  80  


Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met 
                85                  90                  95      


Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln 
            100                 105                 110         


Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val 
        115                 120                 125             


Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala 
    130                 135                 140                 


Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His 
145                 150                 155                 160 


Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn 
                165                 170                 175     


Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr 
            180                 185                 190         


Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly 
        195                 200                 205             


Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val 
    210                 215                 220                 


Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu 
225                 230                 235                 240 


Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp 
                245                 250                 255     


Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile 
            260                 265                 270         


Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe 
        275                 280                 285             


Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro 
    290                 295                 300                 


Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu 
305                 310                 315                 320 


Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala 
                325                 330                 


<210>  1497
<211>  209
<212>  PRT
<213>  homo sapiens

<400>  1497

Met Lys Lys Val Arg Leu Lys Glu Leu Glu Ser Arg Leu Gln Gln Val 
1               5                   10                  15      


Asp Gly Phe Glu Lys Pro Lys Leu Leu Leu Glu Gln Tyr Pro Thr Arg 
            20                  25                  30          


Pro His Ile Ala Ala Cys Met Leu Tyr Thr Ile His Asn Thr Tyr Asp 
        35                  40                  45              


Asp Ile Glu Asn Lys Val Val Ala Asp Leu Gly Cys Gly Cys Gly Val 
    50                  55                  60                  


Leu Ser Ile Gly Thr Ala Met Leu Gly Ala Gly Leu Cys Val Gly Phe 
65                  70                  75                  80  


Asp Ile Asp Glu Asp Ala Leu Glu Ile Phe Asn Arg Asn Ala Glu Glu 
                85                  90                  95      


Phe Glu Leu Thr Asn Ile Asp Met Val Gln Cys Asp Val Cys Leu Leu 
            100                 105                 110         


Ser Asn Arg Met Ser Lys Ser Phe Asp Thr Val Ile Met Asn Pro Pro 
        115                 120                 125             


Phe Gly Thr Lys Asn Asn Lys Gly Thr Asp Met Ala Phe Leu Lys Thr 
    130                 135                 140                 


Ala Leu Glu Met Ala Arg Thr Ala Val Tyr Ser Leu His Lys Ser Ser 
145                 150                 155                 160 


Thr Arg Glu His Val Gln Lys Lys Ala Ala Glu Trp Lys Ile Lys Ile 
                165                 170                 175     


Asp Ile Ile Ala Glu Leu Arg Tyr Asp Leu Pro Ala Ser Tyr Lys Phe 
            180                 185                 190         


His Lys Lys Lys Ser Val Asp Ile Glu Val Asp Leu Ile Arg Phe Ser 
        195                 200                 205             


Phe 
    


<210>  1498
<211>  1027
<212>  PRT
<213>  homo sapiens

<400>  1498

Met Val Ser Ser Asp Arg Pro Val Ser Leu Glu Asp Glu Val Ser His 
1               5                   10                  15      


Ser Met Lys Glu Met Ile Gly Gly Cys Cys Val Cys Ser Asp Glu Arg 
            20                  25                  30          


Gly Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Gly Cys Ser 
        35                  40                  45              


Val Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly 
    50                  55                  60                  


Pro Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val 
65                  70                  75                  80  


Arg Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp 
                85                  90                  95      


Asn Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val 
            100                 105                 110         


Gln Phe Ala Asn Val Ser Thr Met Glu Pro Ile Val Leu Gln Ser Val 
        115                 120                 125             


Pro His Asp Arg Tyr Asn Lys Thr Cys Tyr Ile Cys Asp Glu Gln Gly 
    130                 135                 140                 


Arg Glu Ser Lys Ala Ala Thr Gly Ala Cys Met Thr Cys Asn Lys His 
145                 150                 155                 160 


Gly Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Phe Ala Gly Leu 
                165                 170                 175     


Leu Cys Glu Glu Glu Gly Asn Gly Ala Asp Asn Val Gln Tyr Cys Gly 
            180                 185                 190         


Tyr Cys Lys Tyr His Phe Ser Lys Leu Lys Lys Ser Lys Arg Gly Ser 
        195                 200                 205             


Asn Arg Ser Tyr Asp Gln Ser Leu Ser Asp Ser Ser Ser His Ser Gln 
    210                 215                 220                 


Asp Lys His His Glu Lys Glu Lys Lys Lys Tyr Lys Glu Lys Asp Lys 
225                 230                 235                 240 


His Lys Gln Lys His Lys Lys Gln Pro Glu Pro Ser Pro Ala Leu Val 
                245                 250                 255     


Pro Ser Leu Thr Val Thr Thr Glu Lys Thr Tyr Thr Ser Thr Ser Asn 
            260                 265                 270         


Asn Ser Ile Ser Gly Ser Leu Lys Arg Leu Glu Asp Thr Thr Ala Arg 
        275                 280                 285             


Phe Thr Asn Ala Asn Phe Gln Glu Val Ser Ala His Thr Ser Ser Gly 
    290                 295                 300                 


Lys Asp Val Ser Glu Thr Arg Gly Ser Glu Gly Lys Gly Lys Lys Ser 
305                 310                 315                 320 


Ser Ala His Ser Ser Gly Gln Arg Gly Arg Lys Pro Gly Gly Gly Arg 
                325                 330                 335     


Asn Pro Gly Thr Thr Val Ser Ala Ala Ser Pro Phe Pro Gln Gly Ser 
            340                 345                 350         


Phe Ser Gly Thr Pro Gly Ser Val Lys Ser Ser Ser Gly Ser Ser Val 
        355                 360                 365             


Gln Ser Pro Gln Asp Phe Leu Ser Phe Thr Asp Ser Asp Leu Arg Asn 
    370                 375                 380                 


Asp Ser Tyr Ser His Ser Gln Gln Ser Ser Ala Thr Lys Asp Val His 
385                 390                 395                 400 


Lys Gly Glu Ser Gly Ser Gln Glu Gly Gly Val Asn Ser Phe Ser Thr 
                405                 410                 415     


Leu Ile Gly Leu Pro Ser Thr Ser Ala Val Thr Ser Gln Pro Lys Ser 
            420                 425                 430         


Phe Glu Asn Ser Pro Gly Asp Leu Gly Asn Ser Ser Leu Pro Thr Ala 
        435                 440                 445             


Gly Tyr Lys Arg Ala Gln Thr Ser Gly Ile Glu Glu Glu Thr Val Lys 
    450                 455                 460                 


Glu Lys Lys Arg Lys Gly Asn Lys Gln Ser Lys His Gly Pro Gly Arg 
465                 470                 475                 480 


Pro Lys Gly Asn Lys Asn Gln Glu Asn Val Ser His Leu Ser Val Ser 
                485                 490                 495     


Ser Ala Ser Pro Thr Ser Ser Val Ala Ser Ala Ala Gly Ser Ile Thr 
            500                 505                 510         


Ser Ser Ser Leu Gln Lys Ser Pro Thr Leu Leu Arg Asn Gly Ser Leu 
        515                 520                 525             


Gln Ser Leu Ser Val Gly Ser Ser Pro Val Gly Ser Glu Ile Ser Met 
    530                 535                 540                 


Gln Tyr Arg His Asp Gly Ala Cys Pro Thr Thr Thr Phe Ser Glu Leu 
545                 550                 555                 560 


Leu Asn Ala Ile His Asn Asp Arg Gly Asp Ser Ser Thr Leu Thr Lys 
                565                 570                 575     


Gln Glu Leu Lys Phe Ile Gly Ile Tyr Asn Ser Asn Asp Val Ala Val 
            580                 585                 590         


Ser Phe Pro Asn Val Val Ser Gly Ser Gly Ser Ser Thr Pro Val Ser 
        595                 600                 605             


Ser Ser His Leu Pro Gln Gln Ser Ser Gly His Leu Gln Gln Val Gly 
    610                 615                 620                 


Ala Leu Ser Pro Ser Ala Val Ser Ser Ala Ala Pro Ala Val Ala Thr 
625                 630                 635                 640 


Thr Gln Ala Asn Thr Leu Ser Gly Ser Ser Leu Ser Gln Ala Pro Ser 
                645                 650                 655     


His Met Tyr Gly Asn Arg Ser Asn Ser Ser Met Ala Ala Leu Ile Ala 
            660                 665                 670         


Gln Ser Glu Asn Asn Gln Thr Asp Gln Asp Leu Gly Asp Asn Ser Arg 
        675                 680                 685             


Asn Leu Val Gly Arg Gly Ser Ser Pro Arg Gly Ser Leu Ser Pro Arg 
    690                 695                 700                 


Ser Pro Val Ser Ser Leu Gln Ile Arg Tyr Asp Gln Pro Gly Asn Ser 
705                 710                 715                 720 


Ser Leu Glu Asn Leu Pro Pro Val Ala Ala Ser Ile Glu Gln Leu Leu 
                725                 730                 735     


Glu Arg Gln Trp Ser Glu Gly Gln Gln Phe Leu Leu Glu Gln Gly Thr 
            740                 745                 750         


Pro Ser Asp Ile Leu Gly Met Leu Lys Ser Leu His Gln Leu Gln Val 
        755                 760                 765             


Glu Asn Arg Arg Leu Glu Glu Gln Ile Lys Asn Leu Thr Ala Lys Lys 
    770                 775                 780                 


Glu Arg Leu Gln Leu Leu Asn Ala Gln Leu Ser Val Pro Phe Pro Thr 
785                 790                 795                 800 


Ile Thr Ala Asn Pro Ser Pro Ser His Gln Ile His Thr Phe Ser Ala 
                805                 810                 815     


Gln Thr Ala Pro Thr Thr Asp Ser Leu Asn Ser Ser Lys Ser Pro His 
            820                 825                 830         


Ile Gly Asn Ser Phe Leu Pro Asp Asn Ser Leu Pro Val Leu Asn Gln 
        835                 840                 845             


Asp Leu Thr Ser Ser Gly Gln Ser Thr Ser Ser Ser Ser Ala Leu Ser 
    850                 855                 860                 


Thr Pro Pro Pro Ala Gly Gln Ser Pro Ala Gln Gln Gly Ser Gly Val 
865                 870                 875                 880 


Ser Gly Val Gln Gln Val Asn Gly Val Thr Val Gly Ala Leu Ala Ser 
                885                 890                 895     


Gly Met Gln Pro Val Thr Ser Thr Ile Pro Ala Val Ser Ala Val Gly 
            900                 905                 910         


Gly Ile Ile Gly Ala Leu Pro Gly Asn Gln Leu Ala Ile Asn Gly Ile 
        915                 920                 925             


Val Gly Ala Leu Asn Gly Val Met Gln Thr Pro Val Thr Met Ser Gln 
    930                 935                 940                 


Asn Pro Thr Pro Leu Thr His Thr Thr Val Pro Pro Asn Ala Thr His 
945                 950                 955                 960 


Pro Met Pro Ala Thr Leu Thr Asn Ser Ala Ser Gly Leu Gly Leu Leu 
                965                 970                 975     


Ser Asp Gln Gln Arg Gln Ile Leu Ile His Gln Gln Gln Phe Gln Gln 
            980                 985                 990         


Leu Leu Asn Ser Gln Gln Leu Thr  Pro Val His Arg His  Pro His Phe 
        995                 1000                 1005             


Thr Gln  Leu Pro Pro Thr His  Phe Ser Pro Ser Met  Glu Ile Met 
    1010                 1015                 1020             


Gln Val  Arg Lys 
    1025         


<210>  1499
<211>  201
<212>  PRT
<213>  homo sapiens

<400>  1499

Met Ala Ala Arg Thr Ala Phe Gly Ala Val Cys Arg Arg Leu Trp Gln 
1               5                   10                  15      


Gly Leu Gly Asn Phe Ser Val Asn Thr Ser Lys Gly Asn Thr Ala Lys 
            20                  25                  30          


Asn Gly Gly Leu Leu Leu Ser Thr Asn Met Lys Trp Val Gln Phe Ser 
        35                  40                  45              


Asn Leu His Val Asp Val Pro Lys Asp Leu Thr Lys Pro Val Val Thr 
    50                  55                  60                  


Ile Ser Asp Glu Pro Asp Ile Leu Tyr Lys Arg Leu Ser Val Leu Val 
65                  70                  75                  80  


Lys Gly His Asp Lys Ala Val Leu Asp Ser Tyr Glu Tyr Phe Ala Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Leu Gly Ile Ser Ile Lys Val His Glu Pro Pro 
            100                 105                 110         


Arg Lys Ile Glu Arg Phe Thr Leu Leu Gln Ser Val His Ile Tyr Lys 
        115                 120                 125             


Lys His Arg Val Gln Tyr Glu Met Arg Thr Leu Tyr Arg Cys Leu Glu 
    130                 135                 140                 


Leu Glu His Leu Thr Gly Ser Thr Ala Asp Val Tyr Leu Glu Tyr Ile 
145                 150                 155                 160 


Gln Arg Asn Leu Pro Glu Gly Val Ala Met Glu Val Thr Lys Thr Gln 
                165                 170                 175     


Leu Glu Gln Leu Pro Glu His Ile Lys Glu Pro Ile Trp Glu Thr Leu 
            180                 185                 190         


Ser Glu Glu Lys Glu Glu Ser Lys Ser 
        195                 200     


<210>  1500
<211>  692
<212>  PRT
<213>  homo sapiens

<400>  1500

Met Phe Tyr Phe Arg Gly Cys Gly Arg Trp Val Ala Val Ser Phe Thr 
1               5                   10                  15      


Lys Gln Gln Phe Pro Leu Ala Arg Leu Ser Ser Asp Ser Ala Ala Pro 
            20                  25                  30          


Arg Thr Pro His Phe Asp Val Ile Val Ile Gly Gly Gly His Ala Gly 
        35                  40                  45              


Thr Glu Ala Ala Thr Ala Ala Ala Arg Cys Gly Ser Arg Thr Leu Leu 
    50                  55                  60                  


Leu Thr His Arg Val Asp Thr Ile Gly Gln Met Ser Cys Asn Pro Ser 
65                  70                  75                  80  


Phe Gly Gly Ile Gly Lys Gly His Leu Met Arg Glu Val Asp Ala Leu 
                85                  90                  95      


Asp Gly Leu Cys Ser Arg Ile Cys Asp Gln Ser Gly Val His Tyr Lys 
            100                 105                 110         


Val Leu Asn Arg Arg Lys Gly Pro Ala Val Trp Gly Leu Arg Ala Gln 
        115                 120                 125             


Ile Asp Arg Lys Leu Tyr Lys Gln Asn Met Gln Lys Glu Ile Leu Asn 
    130                 135                 140                 


Thr Pro Leu Leu Thr Val Gln Glu Gly Ala Val Glu Asp Leu Ile Leu 
145                 150                 155                 160 


Thr Glu Pro Glu Pro Glu His Thr Gly Lys Cys Arg Val Ser Gly Val 
                165                 170                 175     


Val Leu Val Asp Gly Ser Thr Val Tyr Ala Glu Ser Val Ile Leu Thr 
            180                 185                 190         


Thr Gly Thr Phe Leu Arg Gly Met Ile Val Ile Gly Leu Glu Thr His 
        195                 200                 205             


Pro Ala Gly Arg Leu Gly Asp Gln Pro Ser Ile Gly Leu Ala Gln Thr 
    210                 215                 220                 


Leu Glu Lys Leu Gly Phe Val Val Gly Arg Leu Lys Thr Gly Thr Pro 
225                 230                 235                 240 


Pro Arg Ile Ala Lys Glu Ser Ile Asn Phe Ser Ile Leu Asn Lys His 
                245                 250                 255     


Ile Pro Asp Asn Pro Ser Ile Pro Phe Ser Phe Thr Asn Glu Thr Val 
            260                 265                 270         


Trp Ile Lys Pro Glu Asp Gln Leu Pro Cys Tyr Leu Thr His Thr Asn 
        275                 280                 285             


Pro Arg Val Asp Glu Ile Val Leu Lys Asn Leu His Leu Asn Ser His 
    290                 295                 300                 


Val Lys Glu Thr Thr Arg Gly Pro Arg Tyr Cys Pro Ser Ile Glu Ser 
305                 310                 315                 320 


Lys Val Leu Arg Phe Pro Asn Arg Leu His Gln Val Trp Leu Glu Pro 
                325                 330                 335     


Glu Gly Met Asp Ser Asp Leu Ile Tyr Pro Gln Gly Leu Ser Met Thr 
            340                 345                 350         


Leu Pro Ala Glu Leu Gln Glu Lys Met Ile Thr Cys Ile Arg Gly Leu 
        355                 360                 365             


Glu Lys Ala Lys Val Ile Gln Pro Gly Tyr Gly Val Gln Tyr Asp Tyr 
    370                 375                 380                 


Leu Asp Pro Arg Gln Ile Thr Pro Ser Leu Glu Thr His Leu Val Gln 
385                 390                 395                 400 


Arg Leu Phe Phe Ala Gly Gln Ile Asn Gly Thr Thr Gly Tyr Glu Glu 
                405                 410                 415     


Ala Ala Ala Gln Gly Val Ile Ala Gly Ile Asn Ala Ser Leu Arg Val 
            420                 425                 430         


Ser Arg Lys Pro Pro Phe Val Val Ser Arg Thr Glu Gly Tyr Ile Gly 
        435                 440                 445             


Val Leu Ile Asp Asp Leu Thr Thr Leu Gly Thr Ser Glu Pro Tyr Arg 
    450                 455                 460                 


Met Phe Thr Ser Arg Val Glu Phe Arg Leu Ser Leu Arg Pro Asp Asn 
465                 470                 475                 480 


Ala Asp Ser Arg Leu Thr Leu Arg Gly Tyr Lys Asp Ala Gly Cys Val 
                485                 490                 495     


Ser Gln Gln Arg Tyr Glu Arg Ala Cys Trp Met Lys Ser Ser Leu Glu 
            500                 505                 510         


Glu Gly Ile Ser Val Leu Lys Ser Ile Glu Phe Leu Ser Ser Lys Trp 
        515                 520                 525             


Lys Lys Leu Ile Pro Glu Ala Ser Ile Ser Thr Ser Arg Ser Leu Pro 
    530                 535                 540                 


Val Arg Ala Leu Asp Val Leu Lys Tyr Glu Glu Val Asp Met Asp Ser 
545                 550                 555                 560 


Leu Ala Lys Ala Val Pro Glu Pro Leu Lys Lys Tyr Thr Lys Cys Arg 
                565                 570                 575     


Glu Leu Ala Glu Arg Leu Lys Ile Glu Ala Thr Tyr Glu Ser Val Leu 
            580                 585                 590         


Phe His Gln Leu Gln Glu Ile Lys Gly Val Gln Gln Asp Glu Ala Leu 
        595                 600                 605             


Gln Leu Pro Lys Asp Leu Asp Tyr Leu Thr Ile Arg Asp Val Ser Leu 
    610                 615                 620                 


Ser His Glu Val Arg Glu Lys Leu His Phe Ser Arg Pro Gln Thr Ile 
625                 630                 635                 640 


Gly Ala Ala Ser Arg Ile Pro Gly Val Thr Pro Ala Ala Ile Ile Asn 
                645                 650                 655     


Leu Leu Arg Phe Val Lys Thr Thr Gln Arg Arg Gln Ser Ala Met Asn 
            660                 665                 670         


Glu Ser Ser Lys Thr Asp Gln Tyr Leu Cys Asp Ala Asp Arg Leu Gln 
        675                 680                 685             


Glu Arg Glu Leu 
    690         


<210>  1501
<211>  698
<212>  PRT
<213>  homo sapiens

<400>  1501

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu 
                85                  90                  95      


Gly Asp Ser Glu Tyr Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp 
            100                 105                 110         


Lys Arg Leu Gln Glu Leu Gly Ala Arg His Phe Tyr Asp Thr Gly His 
        115                 120                 125             


Ala Asp Asp Cys Val Gly Leu Glu Leu Val Val Glu Pro Trp Ile Ala 
    130                 135                 140                 


Gly Leu Trp Pro Ala Leu Arg Lys His Phe Arg Ser Ser Arg Gly Gln 
145                 150                 155                 160 


Glu Glu Ile Ser Gly Ala Leu Pro Val Ala Ser Pro Ala Ser Ser Arg 
                165                 170                 175     


Thr Asp Leu Val Lys Ser Glu Leu Leu His Ile Glu Ser Gln Val Glu 
            180                 185                 190         


Leu Leu Arg Phe Asp Asp Ser Gly Arg Lys Asp Ser Glu Val Leu Lys 
        195                 200                 205             


Gln Asn Ala Val Asn Ser Asn Gln Ser Asn Val Val Ile Glu Asp Phe 
    210                 215                 220                 


Glu Ser Ser Leu Thr Arg Ser Val Pro Pro Leu Ser Gln Ala Ser Leu 
225                 230                 235                 240 


Asn Ile Pro Gly Leu Pro Pro Glu Tyr Leu Gln Val His Leu Gln Glu 
                245                 250                 255     


Ser Leu Gly Gln Glu Glu Ser Gln Val Ser Val Thr Ser Ala Asp Pro 
            260                 265                 270         


Val Phe Gln Val Pro Ile Ser Lys Ala Val Gln Leu Thr Thr Asn Asp 
        275                 280                 285             


Ala Ile Lys Thr Thr Leu Leu Val Glu Leu Asp Ile Ser Asn Thr Asp 
    290                 295                 300                 


Phe Ser Tyr Gln Pro Gly Asp Ala Phe Ser Val Ile Cys Pro Asn Ser 
305                 310                 315                 320 


Asp Ser Glu Val Gln Ser Leu Leu Gln Arg Leu Gln Leu Glu Asp Lys 
                325                 330                 335     


Arg Glu His Cys Val Leu Leu Lys Ile Lys Ala Asp Thr Lys Lys Lys 
            340                 345                 350         


Gly Ala Thr Leu Pro Gln His Ile Pro Ala Gly Cys Ser Leu Gln Phe 
        355                 360                 365             


Ile Phe Thr Trp Cys Leu Glu Ile Arg Ala Ile Pro Lys Lys Ala Phe 
    370                 375                 380                 


Leu Arg Ala Leu Val Asp Tyr Thr Ser Asp Ser Ala Glu Lys Arg Arg 
385                 390                 395                 400 


Leu Gln Glu Leu Cys Ser Lys Gln Gly Ala Ala Asp Tyr Ser Arg Phe 
                405                 410                 415     


Val Arg Asp Ala Cys Ala Cys Leu Leu Asp Leu Leu Leu Ala Phe Pro 
            420                 425                 430         


Ser Cys Gln Pro Pro Leu Ser Leu Leu Leu Glu His Leu Pro Lys Leu 
        435                 440                 445             


Gln Pro Arg Pro Tyr Ser Cys Ala Ser Ser Ser Leu Phe His Pro Gly 
    450                 455                 460                 


Lys Leu His Phe Val Phe Asn Ile Val Glu Phe Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Thr Glu Val Leu Arg Lys Gly Val Cys Thr Gly Trp Leu Ala Leu Leu 
                485                 490                 495     


Val Ala Ser Val Leu Gln Pro Asn Ile His Ala Ser His Glu Asp Ser 
            500                 505                 510         


Gly Lys Ala Leu Ala Pro Lys Ile Ser Ile Ser Pro Arg Thr Thr Asn 
        515                 520                 525             


Ser Phe His Leu Pro Asp Asp Pro Ser Ile Pro Ile Ile Met Val Gly 
    530                 535                 540                 


Pro Gly Thr Gly Ile Ala Pro Phe Ile Gly Phe Leu Gln His Arg Glu 
545                 550                 555                 560 


Lys Leu Gln Glu Gln His Pro Asp Gly Asn Phe Gly Ala Met Trp Leu 
                565                 570                 575     


Phe Phe Gly Cys Arg His Lys Asp Arg Asp Tyr Leu Phe Arg Lys Glu 
            580                 585                 590         


Leu Arg His Phe Leu Lys His Gly Ile Leu Thr His Leu Lys Val Ser 
        595                 600                 605             


Phe Ser Arg Asp Ala Pro Val Gly Glu Glu Glu Ala Pro Ala Lys Tyr 
    610                 615                 620                 


Val Gln Asp Asn Ile Gln Leu His Gly Gln Gln Val Ala Arg Ile Leu 
625                 630                 635                 640 


Leu Gln Glu Asn Gly His Ile Tyr Val Cys Gly Asp Ala Lys Asn Met 
                645                 650                 655     


Ala Lys Asp Val His Asp Ala Leu Val Gln Ile Ile Ser Lys Glu Val 
            660                 665                 670         


Gly Val Glu Lys Leu Glu Ala Met Lys Thr Leu Ala Thr Leu Lys Glu 
        675                 680                 685             


Glu Lys Arg Tyr Leu Gln Asp Ile Trp Ser 
    690                 695             


<210>  1502
<211>  221
<212>  PRT
<213>  homo sapiens

<400>  1502

Met Ala Ala Ala Val Arg Met Asn Ile Gln Met Leu Leu Glu Ala Ala 
1               5                   10                  15      


Asp Tyr Leu Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser 
            20                  25                  30          


Met Leu Pro Tyr Asn Asn Lys Asp Arg Asp Ala Leu Lys Arg Arg Asn 
        35                  40                  45              


Lys Ser Lys Lys Asn Asn Ser Ser Ser Arg Ser Thr His Asn Glu Met 
    50                  55                  60                  


Glu Lys Asn Arg Arg Ala His Leu Arg Leu Cys Leu Glu Lys Leu Lys 
65                  70                  75                  80  


Gly Leu Val Pro Leu Gly Pro Glu Ser Ser Arg His Thr Thr Leu Ser 
                85                  90                  95      


Leu Leu Thr Lys Ala Lys Leu His Ile Lys Lys Leu Glu Asp Cys Asp 
            100                 105                 110         


Arg Lys Ala Val His Gln Ile Asp Gln Leu Gln Arg Glu Gln Arg His 
        115                 120                 125             


Leu Lys Arg Gln Leu Glu Lys Leu Gly Ile Glu Arg Ile Arg Met Asp 
    130                 135                 140                 


Ser Ile Gly Ser Thr Val Ser Ser Glu Arg Ser Asp Ser Asp Arg Glu 
145                 150                 155                 160 


Glu Ile Asp Val Asp Val Glu Ser Thr Asp Tyr Leu Thr Gly Asp Leu 
                165                 170                 175     


Asp Trp Ser Ser Ser Ser Val Ser Asp Ser Asp Glu Arg Gly Ser Met 
            180                 185                 190         


Gln Ser Leu Gly Ser Asp Glu Gly Tyr Ser Ser Thr Ser Ile Lys Arg 
        195                 200                 205             


Ile Lys Leu Gln Asp Ser His Lys Ala Cys Leu Gly Leu 
    210                 215                 220     


<210>  1503
<211>  1960
<212>  PRT
<213>  homo sapiens

<400>  1503

Met Ala Gln Gln Ala Ala Asp Lys Tyr Leu Tyr Val Asp Lys Asn Phe 
1               5                   10                  15      


Ile Asn Asn Pro Leu Ala Gln Ala Asp Trp Ala Ala Lys Lys Leu Val 
            20                  25                  30          


Trp Val Pro Ser Asp Lys Ser Gly Phe Glu Pro Ala Ser Leu Lys Glu 
        35                  40                  45              


Glu Val Gly Glu Glu Ala Ile Val Glu Leu Val Glu Asn Gly Lys Lys 
    50                  55                  60                  


Val Lys Val Asn Lys Asp Asp Ile Gln Lys Met Asn Pro Pro Lys Phe 
65                  70                  75                  80  


Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu Asn Glu Ala Ser 
                85                  90                  95      


Val Leu His Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu Ile Tyr Thr 
            100                 105                 110         


Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr Lys Asn Leu Pro 
        115                 120                 125             


Ile Tyr Ser Glu Glu Ile Val Glu Met Tyr Lys Gly Lys Lys Arg His 
    130                 135                 140                 


Glu Met Pro Pro His Ile Tyr Ala Ile Thr Asp Thr Ala Tyr Arg Ser 
145                 150                 155                 160 


Met Met Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys Thr Gly Glu Ser 
                165                 170                 175     


Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile Gln Tyr Leu Ala 
            180                 185                 190         


Tyr Val Ala Ser Ser His Lys Ser Lys Lys Asp Gln Gly Glu Leu Glu 
        195                 200                 205             


Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala 
    210                 215                 220                 


Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg 
225                 230                 235                 240 


Ile Asn Phe Asp Val Asn Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr 
                245                 250                 255     


Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys Glu Glu Arg 
            260                 265                 270         


Thr Phe His Ile Phe Tyr Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 
        275                 280                 285             


Lys Thr Asp Leu Leu Leu Glu Pro Tyr Asn Lys Tyr Arg Phe Leu Ser 
    290                 295                 300                 


Asn Gly His Val Thr Ile Pro Gly Gln Gln Asp Lys Asp Met Phe Gln 
305                 310                 315                 320 


Glu Thr Met Glu Ala Met Arg Ile Met Gly Ile Pro Glu Glu Glu Gln 
                325                 330                 335     


Met Gly Leu Leu Arg Val Ile Ser Gly Val Leu Gln Leu Gly Asn Ile 
            340                 345                 350         


Val Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn 
        355                 360                 365             


Thr Ala Ala Gln Lys Val Ser His Leu Leu Gly Ile Asn Val Thr Asp 
    370                 375                 380                 


Phe Thr Arg Gly Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Tyr 
385                 390                 395                 400 


Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Ile Glu Ala 
                405                 410                 415     


Leu Ala Lys Ala Thr Tyr Glu Arg Met Phe Arg Trp Leu Val Leu Arg 
            420                 425                 430         


Ile Asn Lys Ala Leu Asp Lys Thr Lys Arg Gln Gly Ala Ser Phe Ile 
        435                 440                 445             


Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Asp Leu Asn Ser Phe 
    450                 455                 460                 


Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe 
465                 470                 475                 480 


Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly 
                485                 490                 495     


Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile 
            500                 505                 510         


Asp Leu Ile Glu Lys Pro Ala Gly Pro Pro Gly Ile Leu Ala Leu Leu 
        515                 520                 525             


Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu 
    530                 535                 540                 


Lys Val Met Gln Glu Gln Gly Thr His Pro Lys Phe Gln Lys Pro Lys 
545                 550                 555                 560 


Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly Lys 
                565                 570                 575     


Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro Leu 
            580                 585                 590         


Asn Asp Asn Ile Ala Thr Leu Leu His Gln Ser Ser Asp Lys Phe Val 
        595                 600                 605             


Ser Glu Leu Trp Lys Asp Val Asp Arg Ile Ile Gly Leu Asp Gln Val 
    610                 615                 620                 


Ala Gly Met Ser Glu Thr Ala Leu Pro Gly Ala Phe Lys Thr Arg Lys 
625                 630                 635                 640 


Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Ala Lys 
                645                 650                 655     


Leu Met Ala Thr Leu Arg Asn Thr Asn Pro Asn Phe Val Arg Cys Ile 
            660                 665                 670         


Ile Pro Asn His Glu Lys Lys Ala Gly Lys Leu Asp Pro His Leu Val 
        675                 680                 685             


Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys 
    690                 695                 700                 


Arg Gln Gly Phe Pro Asn Arg Val Val Phe Gln Glu Phe Arg Gln Arg 
705                 710                 715                 720 


Tyr Glu Ile Leu Thr Pro Asn Ser Ile Pro Lys Gly Phe Met Asp Gly 
                725                 730                 735     


Lys Gln Ala Cys Val Leu Met Ile Lys Ala Leu Glu Leu Asp Ser Asn 
            740                 745                 750         


Leu Tyr Arg Ile Gly Gln Ser Lys Val Phe Phe Arg Ala Gly Val Leu 
        755                 760                 765             


Ala His Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Ile 
    770                 775                 780                 


Gly Phe Gln Ala Cys Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala 
785                 790                 795                 800 


Lys Arg Gln Gln Gln Leu Thr Ala Met Lys Val Leu Gln Arg Asn Cys 
                805                 810                 815     


Ala Ala Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr 
            820                 825                 830         


Lys Val Lys Pro Leu Leu Gln Val Ser Arg Gln Glu Glu Glu Met Met 
        835                 840                 845             


Ala Lys Glu Glu Glu Leu Val Lys Val Arg Glu Lys Gln Leu Ala Ala 
    850                 855                 860                 


Glu Asn Arg Leu Thr Glu Met Glu Thr Leu Gln Ser Gln Leu Met Ala 
865                 870                 875                 880 


Glu Lys Leu Gln Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Cys 
                885                 890                 895     


Ala Glu Ala Glu Glu Leu Arg Ala Arg Leu Thr Ala Lys Lys Gln Glu 
            900                 905                 910         


Leu Glu Glu Ile Cys His Asp Leu Glu Ala Arg Val Glu Glu Glu Glu 
        915                 920                 925             


Glu Arg Cys Gln His Leu Gln Ala Glu Lys Lys Lys Met Gln Gln Asn 
    930                 935                 940                 


Ile Gln Glu Leu Glu Glu Gln Leu Glu Glu Glu Glu Ser Ala Arg Gln 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Val Thr Thr Glu Ala Lys Leu Lys Lys Leu 
                965                 970                 975     


Glu Glu Glu Gln Ile Ile Leu Glu Asp Gln Asn Cys Lys Leu Ala Lys 
            980                 985                 990         


Glu Lys Lys Leu Leu Glu Asp Arg  Ile Ala Glu Phe Thr  Thr Asn Leu 
        995                 1000                 1005             


Thr Glu  Glu Glu Glu Lys Ser  Lys Ser Leu Ala Lys  Leu Lys Asn 
    1010                 1015                 1020             


Lys His  Glu Ala Met Ile Thr  Asp Leu Glu Glu Arg  Leu Arg Arg 
    1025                 1030                 1035             


Glu Glu  Lys Gln Arg Gln Glu  Leu Glu Lys Thr Arg  Arg Lys Leu 
    1040                 1045                 1050             


Glu Gly  Asp Ser Thr Asp Leu  Ser Asp Gln Ile Ala  Glu Leu Gln 
    1055                 1060                 1065             


Ala Gln  Ile Ala Glu Leu Lys  Met Gln Leu Ala Lys  Lys Glu Glu 
    1070                 1075                 1080             


Glu Leu  Gln Ala Ala Leu Ala  Arg Val Glu Glu Glu  Ala Ala Gln 
    1085                 1090                 1095             


Lys Asn  Met Ala Leu Lys Lys  Ile Arg Glu Leu Glu  Ser Gln Ile 
    1100                 1105                 1110             


Ser Glu  Leu Gln Glu Asp Leu  Glu Ser Glu Arg Ala  Ser Arg Asn 
    1115                 1120                 1125             


Lys Ala  Glu Lys Gln Lys Arg  Asp Leu Gly Glu Glu  Leu Glu Ala 
    1130                 1135                 1140             


Leu Lys  Thr Glu Leu Glu Asp  Thr Leu Asp Ser Thr  Ala Ala Gln 
    1145                 1150                 1155             


Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu Val Asn  Ile Leu Lys 
    1160                 1165                 1170             


Lys Thr  Leu Glu Glu Glu Ala  Lys Thr His Glu Ala  Gln Ile Gln 
    1175                 1180                 1185             


Glu Met  Arg Gln Lys His Ser  Gln Ala Val Glu Glu  Leu Ala Glu 
    1190                 1195                 1200             


Gln Leu  Glu Gln Thr Lys Arg  Val Lys Ala Asn Leu  Glu Lys Ala 
    1205                 1210                 1215             


Lys Gln  Thr Leu Glu Asn Glu  Arg Gly Glu Leu Ala  Asn Glu Val 
    1220                 1225                 1230             


Lys Val  Leu Leu Gln Gly Lys  Gly Asp Ser Glu His  Lys Arg Lys 
    1235                 1240                 1245             


Lys Val  Glu Ala Gln Leu Gln  Glu Leu Gln Val Lys  Phe Asn Glu 
    1250                 1255                 1260             


Gly Glu  Arg Val Arg Thr Glu  Leu Ala Asp Lys Val  Thr Lys Leu 
    1265                 1270                 1275             


Gln Val  Glu Leu Asp Asn Val  Thr Gly Leu Leu Ser  Gln Ser Asp 
    1280                 1285                 1290             


Ser Lys  Ser Ser Lys Leu Thr  Lys Asp Phe Ser Ala  Leu Glu Ser 
    1295                 1300                 1305             


Gln Leu  Gln Asp Thr Gln Glu  Leu Leu Gln Glu Glu  Asn Arg Gln 
    1310                 1315                 1320             


Lys Leu  Ser Leu Ser Thr Lys  Leu Lys Gln Val Glu  Asp Glu Lys 
    1325                 1330                 1335             


Asn Ser  Phe Arg Glu Gln Leu  Glu Glu Glu Glu Glu  Ala Lys His 
    1340                 1345                 1350             


Asn Leu  Glu Lys Gln Ile Ala  Thr Leu His Ala Gln  Val Ala Asp 
    1355                 1360                 1365             


Met Lys  Lys Lys Met Glu Asp  Ser Val Gly Cys Leu  Glu Thr Ala 
    1370                 1375                 1380             


Glu Glu  Val Lys Arg Lys Leu  Gln Lys Asp Leu Glu  Gly Leu Ser 
    1385                 1390                 1395             


Gln Arg  His Glu Glu Lys Val  Ala Ala Tyr Asp Lys  Leu Glu Lys 
    1400                 1405                 1410             


Thr Lys  Thr Arg Leu Gln Gln  Glu Leu Asp Asp Leu  Leu Val Asp 
    1415                 1420                 1425             


Leu Asp  His Gln Arg Gln Ser  Ala Cys Asn Leu Glu  Lys Lys Gln 
    1430                 1435                 1440             


Lys Lys  Phe Asp Gln Leu Leu  Ala Glu Glu Lys Thr  Ile Ser Ala 
    1445                 1450                 1455             


Lys Tyr  Ala Glu Glu Arg Asp  Arg Ala Glu Ala Glu  Ala Arg Glu 
    1460                 1465                 1470             


Lys Glu  Thr Lys Ala Leu Ser  Leu Ala Arg Ala Leu  Glu Glu Ala 
    1475                 1480                 1485             


Met Glu  Gln Lys Ala Glu Leu  Glu Arg Leu Asn Lys  Gln Phe Arg 
    1490                 1495                 1500             


Thr Glu  Met Glu Asp Leu Met  Ser Ser Lys Asp Asp  Val Gly Lys 
    1505                 1510                 1515             


Ser Val  His Glu Leu Glu Lys  Ser Lys Arg Ala Leu  Glu Gln Gln 
    1520                 1525                 1530             


Val Glu  Glu Met Lys Thr Gln  Leu Glu Glu Leu Glu  Asp Glu Leu 
    1535                 1540                 1545             


Gln Ala  Thr Glu Asp Ala Lys  Leu Arg Leu Glu Val  Asn Leu Gln 
    1550                 1555                 1560             


Ala Met  Lys Ala Gln Phe Glu  Arg Asp Leu Gln Gly  Arg Asp Glu 
    1565                 1570                 1575             


Gln Ser  Glu Glu Lys Lys Lys  Gln Leu Val Arg Gln  Val Arg Glu 
    1580                 1585                 1590             


Met Glu  Ala Glu Leu Glu Asp  Glu Arg Lys Gln Arg  Ser Met Ala 
    1595                 1600                 1605             


Val Ala  Ala Arg Lys Lys Leu  Glu Met Asp Leu Lys  Asp Leu Glu 
    1610                 1615                 1620             


Ala His  Ile Asp Ser Ala Asn  Lys Asn Arg Asp Glu  Ala Ile Lys 
    1625                 1630                 1635             


Gln Leu  Arg Lys Leu Gln Ala  Gln Met Lys Asp Cys  Met Arg Glu 
    1640                 1645                 1650             


Leu Asp  Asp Thr Arg Ala Ser  Arg Glu Glu Ile Leu  Ala Gln Ala 
    1655                 1660                 1665             


Lys Glu  Asn Glu Lys Lys Leu  Lys Ser Met Glu Ala  Glu Met Ile 
    1670                 1675                 1680             


Gln Leu  Gln Glu Glu Leu Ala  Ala Ala Glu Arg Ala  Lys Arg Gln 
    1685                 1690                 1695             


Ala Gln  Gln Glu Arg Asp Glu  Leu Ala Asp Glu Ile  Ala Asn Ser 
    1700                 1705                 1710             


Ser Gly  Lys Gly Ala Leu Ala  Leu Glu Glu Lys Arg  Arg Leu Glu 
    1715                 1720                 1725             


Ala Arg  Ile Ala Gln Leu Glu  Glu Glu Leu Glu Glu  Glu Gln Gly 
    1730                 1735                 1740             


Asn Thr  Glu Leu Ile Asn Asp  Arg Leu Lys Lys Ala  Asn Leu Gln 
    1745                 1750                 1755             


Ile Asp  Gln Ile Asn Thr Asp  Leu Asn Leu Glu Arg  Ser His Ala 
    1760                 1765                 1770             


Gln Lys  Asn Glu Asn Ala Arg  Gln Gln Leu Glu Arg  Gln Asn Lys 
    1775                 1780                 1785             


Glu Leu  Lys Val Lys Leu Gln  Glu Met Glu Gly Thr  Val Lys Ser 
    1790                 1795                 1800             


Lys Tyr  Lys Ala Ser Ile Thr  Ala Leu Glu Ala Lys  Ile Ala Gln 
    1805                 1810                 1815             


Leu Glu  Glu Gln Leu Asp Asn  Glu Thr Lys Glu Arg  Gln Ala Ala 
    1820                 1825                 1830             


Cys Lys  Gln Val Arg Arg Thr  Glu Lys Lys Leu Lys  Asp Val Leu 
    1835                 1840                 1845             


Leu Gln  Val Asp Asp Glu Arg  Arg Asn Ala Glu Gln  Tyr Lys Asp 
    1850                 1855                 1860             


Gln Ala  Asp Lys Ala Ser Thr  Arg Leu Lys Gln Leu  Lys Arg Gln 
    1865                 1870                 1875             


Leu Glu  Glu Ala Glu Glu Glu  Ala Gln Arg Ala Asn  Ala Ser Arg 
    1880                 1885                 1890             


Arg Lys  Leu Gln Arg Glu Leu  Glu Asp Ala Thr Glu  Thr Ala Asp 
    1895                 1900                 1905             


Ala Met  Asn Arg Glu Val Ser  Ser Leu Lys Asn Lys  Leu Arg Arg 
    1910                 1915                 1920             


Gly Asp  Leu Pro Phe Val Val  Pro Arg Arg Met Ala  Arg Lys Gly 
    1925                 1930                 1935             


Ala Gly  Asp Gly Ser Asp Glu  Glu Val Asp Gly Lys  Ala Asp Gly 
    1940                 1945                 1950             


Ala Glu  Ala Lys Pro Ala Glu  
    1955                 1960 


<210>  1504
<211>  2548
<212>  PRT
<213>  homo sapiens

<400>  1504

Met Asn Ile Asn Asp Gly Gly Arg Arg Arg Phe Glu Asp Asn Glu His 
1               5                   10                  15      


Thr Leu Arg Ile Tyr Pro Gly Ala Ile Ser Glu Gly Thr Ile Tyr Cys 
            20                  25                  30          


Pro Ile Pro Ala Arg Lys Asn Ser Thr Ala Ala Glu Val Ile Glu Ser 
        35                  40                  45              


Leu Ile Asn Lys Leu His Leu Asp Lys Thr Lys Cys Tyr Val Leu Ala 
    50                  55                  60                  


Glu Val Lys Glu Phe Gly Gly Glu Glu Trp Ile Leu Asn Pro Thr Asp 
65                  70                  75                  80  


Cys Pro Val Gln Arg Met Met Leu Trp Pro Arg Met Ala Leu Glu Asn 
                85                  90                  95      


Arg Leu Ser Gly Glu Asp Tyr Arg Phe Leu Leu Arg Glu Lys Asn Leu 
            100                 105                 110         


Asp Gly Ser Ile His Tyr Gly Ser Leu Gln Ser Trp Leu Arg Val Thr 
        115                 120                 125             


Glu Glu Arg Arg Arg Met Met Glu Arg Gly Phe Leu Pro Gln Pro Gln 
    130                 135                 140                 


Gln Lys Asp Phe Asp Asp Leu Cys Ser Leu Pro Asp Leu Asn Glu Lys 
145                 150                 155                 160 


Thr Leu Leu Glu Asn Leu Arg Asn Arg Phe Lys His Glu Lys Ile Tyr 
                165                 170                 175     


Thr Tyr Val Gly Ser Ile Leu Ile Val Ile Asn Pro Phe Lys Phe Leu 
            180                 185                 190         


Pro Ile Tyr Asn Pro Lys Tyr Val Lys Met Tyr Asp Asn His Gln Leu 
        195                 200                 205             


Gly Lys Leu Glu Pro His Ile Tyr Ala Val Ala Asp Val Ala Tyr His 
    210                 215                 220                 


Ala Met Leu Gln Arg Lys Lys Asn Gln Cys Ile Val Ile Ser Gly Glu 
225                 230                 235                 240 


Ser Gly Ser Gly Lys Thr Gln Ser Thr Asn Phe Leu Ile His His Leu 
                245                 250                 255     


Thr Ala Leu Ser Gln Lys Gly Phe Ala Ser Gly Val Glu Gln Ile Ile 
            260                 265                 270         


Leu Gly Ala Gly Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ala 
        275                 280                 285             


His Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Val Asn Tyr 
    290                 295                 300                 


Gln Glu Thr Gly Thr Val Leu Gly Ala Tyr Val Glu Lys Tyr Leu Leu 
305                 310                 315                 320 


Glu Lys Ser Arg Leu Val Tyr Gln Glu His Asn Glu Arg Asn Tyr His 
                325                 330                 335     


Val Phe Tyr Tyr Leu Leu Ala Gly Ala Ser Glu Asp Glu Arg Ser Ala 
            340                 345                 350         


Phe His Leu Lys Gln Pro Glu Glu Tyr His Tyr Leu Asn Gln Ile Thr 
        355                 360                 365             


Lys Lys Pro Leu Arg Gln Ser Trp Asp Asp Tyr Cys Tyr Asp Ser Glu 
    370                 375                 380                 


Pro Asp Cys Phe Thr Val Glu Gly Glu Asp Leu Arg His Asp Phe Glu 
385                 390                 395                 400 


Arg Leu Gln Leu Ala Met Glu Met Val Gly Phe Leu Pro Lys Thr Arg 
                405                 410                 415     


Arg Gln Ile Phe Ser Leu Leu Ser Ala Ile Leu His Leu Gly Asn Ile 
            420                 425                 430         


Cys Tyr Lys Lys Lys Thr Tyr Arg Asp Asp Ser Ile Asp Ile Cys Asn 
        435                 440                 445             


Pro Glu Val Leu Pro Ile Val Ser Glu Leu Leu Glu Val Lys Glu Glu 
    450                 455                 460                 


Met Leu Phe Glu Ala Leu Val Thr Arg Lys Thr Val Thr Val Gly Glu 
465                 470                 475                 480 


Lys Leu Ile Leu Pro Tyr Lys Leu Ala Glu Ala Val Thr Val Arg Asn 
                485                 490                 495     


Ser Met Ala Lys Ser Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Phe 
            500                 505                 510         


Arg Ile Asn His Ala Leu Leu Asn Ser Lys Asp Leu Glu His Asn Thr 
        515                 520                 525             


Lys Thr Leu Ser Ile Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Tyr 
    530                 535                 540                 


Glu Asn Asn Ser Phe Glu Gln Phe Cys Ile Asn Phe Ala Asn Glu Arg 
545                 550                 555                 560 


Leu Gln His Tyr Phe Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu 
                565                 570                 575     


Tyr Arg Thr Glu Gly Ile Ser Trp His Asn Ile Asp Tyr Ile Asp Asn 
            580                 585                 590         


Thr Cys Cys Ile Asn Leu Ile Ser Lys Lys Pro Thr Gly Leu Leu His 
        595                 600                 605             


Leu Leu Asp Glu Glu Ser Asn Phe Pro Gln Ala Thr Asn Gln Thr Leu 
    610                 615                 620                 


Leu Asp Lys Phe Lys His Gln His Glu Asp Asn Ser Tyr Ile Glu Phe 
625                 630                 635                 640 


Pro Ala Val Met Glu Pro Ala Phe Ile Ile Lys His Tyr Ala Gly Lys 
                645                 650                 655     


Val Lys Tyr Gly Val Lys Asp Phe Arg Glu Lys Asn Thr Asp His Met 
            660                 665                 670         


Arg Pro Asp Ile Val Ala Leu Leu Arg Ser Ser Lys Asn Ala Phe Ile 
        675                 680                 685             


Ser Gly Met Ile Gly Ile Asp Pro Val Ala Val Phe Arg Trp Ala Ile 
    690                 695                 700                 


Leu Arg Ala Phe Phe Arg Ala Met Val Ala Phe Arg Glu Ala Gly Lys 
705                 710                 715                 720 


Arg Asn Ile His Arg Lys Thr Gly His Asp Asp Thr Ala Pro Cys Ala 
                725                 730                 735     


Ile Leu Lys Ser Met Asp Ser Phe Ser Phe Leu Gln His Pro Val His 
            740                 745                 750         


Gln Arg Ser Leu Glu Ile Leu Gln Arg Cys Lys Glu Glu Lys Tyr Ser 
        755                 760                 765             


Ile Thr Arg Lys Asn Pro Arg Thr Pro Leu Ser Asp Leu Gln Gly Met 
    770                 775                 780                 


Asn Ala Leu Asn Glu Lys Asn Gln His Asp Thr Phe Asp Ile Ala Trp 
785                 790                 795                 800 


Asn Gly Arg Thr Gly Ile Arg Gln Ser Arg Leu Ser Ser Gly Thr Ser 
                805                 810                 815     


Leu Leu Asp Lys Asp Gly Ile Phe Ala Asn Ser Thr Ser Ser Lys Leu 
            820                 825                 830         


Leu Glu Arg Ala His Gly Ile Leu Thr Arg Asn Lys Asn Phe Lys Ser 
        835                 840                 845             


Lys Pro Ala Leu Pro Lys His Leu Leu Glu Val Asn Ser Leu Lys His 
    850                 855                 860                 


Leu Thr Arg Leu Thr Leu Gln Asp Arg Ile Thr Lys Ser Leu Leu His 
865                 870                 875                 880 


Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala Gln Phe Gln Ala 
                885                 890                 895     


Ser Leu Ser Lys Leu Met Glu Thr Leu Gly Gln Ala Glu Pro Tyr Phe 
            900                 905                 910         


Val Lys Cys Ile Arg Ser Asn Ala Glu Lys Leu Pro Leu Arg Phe Ser 
        915                 920                 925             


Asp Val Leu Val Leu Arg Gln Leu Arg Tyr Thr Gly Met Leu Glu Thr 
    930                 935                 940                 


Val Arg Ile Arg Gln Ser Gly Tyr Ser Ser Lys Tyr Ser Phe Gln Asp 
945                 950                 955                 960 


Phe Val Ser His Phe His Val Leu Leu Pro Arg Asn Ile Ile Pro Ser 
                965                 970                 975     


Lys Phe Asn Ile Gln Asp Phe Phe Arg Lys Ile Asn Leu Asn Pro Asp 
            980                 985                 990         


Asn Tyr Gln Val Gly Lys Thr Met  Val Phe Leu Lys Glu  Gln Glu Arg 
        995                 1000                 1005             


Gln His  Leu Gln Asp Leu Leu  His Gln Glu Val Leu  Arg Arg Ile 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Trp Phe  Arg Val Leu Leu Cys  Arg Gln His 
    1025                 1030                 1035             


Phe Leu  His Leu Arg Gln Ala  Ser Val Ile Ile Gln  Arg Phe Trp 
    1040                 1045                 1050             


Arg Asn  Tyr Leu Asn Gln Lys  Gln Val Arg Asp Ala  Ala Val Gln 
    1055                 1060                 1065             


Lys Asp  Ala Phe Val Met Ala  Ser Ala Ala Ala Leu  Leu Gln Ala 
    1070                 1075                 1080             


Ser Trp  Arg Ala His Leu Glu  Arg Gln Arg Tyr Leu  Glu Leu Arg 
    1085                 1090                 1095             


Ala Ala  Ala Ile Val Ile Gln  Gln Lys Trp Arg Asp  Tyr Tyr Arg 
    1100                 1105                 1110             


Arg Arg  His Met Ala Ala Ile  Cys Ile Gln Ala Arg  Trp Lys Ala 
    1115                 1120                 1125             


Tyr Arg  Glu Ser Lys Arg Tyr  Gln Glu Gln Arg Lys  Lys Ile Ile 
    1130                 1135                 1140             


Leu Leu  Gln Ser Thr Cys Arg  Gly Phe Arg Ala Arg  Gln Arg Phe 
    1145                 1150                 1155             


Lys Ala  Leu Lys Glu Gln Arg  Leu Arg Glu Thr Lys  Pro Glu Val 
    1160                 1165                 1170             


Gly Leu  Val Asn Ile Lys Gly  Tyr Gly Ser Leu Glu  Ile Gln Gly 
    1175                 1180                 1185             


Ser Asp  Pro Ser Gly Trp Glu  Asp Cys Ser Phe Asp  Asn Arg Ile 
    1190                 1195                 1200             


Lys Ala  Ile Glu Glu Cys Lys  Ser Val Ile Glu Ser  Asn Arg Ile 
    1205                 1210                 1215             


Ser Arg  Glu Ser Ser Val Asp  Cys Leu Lys Glu Ser  Pro Asn Lys 
    1220                 1225                 1230             


Gln Gln  Glu Arg Ala Gln Ser  Gln Ser Gly Val Asp  Leu Gln Glu 
    1235                 1240                 1245             


Asp Val  Leu Val Arg Glu Arg  Pro Arg Ser Leu Glu  Asp Leu His 
    1250                 1255                 1260             


Gln Lys  Lys Val Gly Arg Ala  Lys Arg Glu Ser Arg  Arg Met Arg 
    1265                 1270                 1275             


Glu Leu  Glu Gln Ala Ile Phe  Ser Leu Glu Leu Leu  Lys Val Arg 
    1280                 1285                 1290             


Ser Leu  Gly Gly Ile Ser Pro  Ser Glu Asp Arg Arg  Trp Ser Thr 
    1295                 1300                 1305             


Glu Leu  Val Pro Glu Gly Leu  Gln Ser Pro Arg Gly  Thr Pro Asp 
    1310                 1315                 1320             


Ser Glu  Ser Ser Gln Gly Ser  Leu Glu Leu Leu Ser  Tyr Glu Glu 
    1325                 1330                 1335             


Ser Gln  Lys Ser Lys Leu Glu  Ser Val Ile Ser Asp  Glu Gly Asp 
    1340                 1345                 1350             


Leu Gln  Phe Pro Ser Pro Lys  Ile Ser Ser Ser Pro  Lys Phe Asp 
    1355                 1360                 1365             


Ser Arg  Asp Asn Ala Leu Ser  Ala Ser Asn Glu Thr  Ser Ser Ala 
    1370                 1375                 1380             


Glu His  Leu Lys Asp Gly Thr  Met Lys Glu Met Val  Val Cys Ser 
    1385                 1390                 1395             


Ser Glu  Ser Ile Thr Cys Lys  Pro Gln Leu Lys Asp  Ser Phe Ile 
    1400                 1405                 1410             


Ser Asn  Ser Leu Pro Thr Phe  Phe Tyr Ile Pro Gln  Gln Asp Pro 
    1415                 1420                 1425             


Leu Lys  Thr Asn Ser Gln Leu  Asp Thr Ser Ile Gln  Arg Asn Lys 
    1430                 1435                 1440             


Leu Leu  Glu Asn Glu Asp Thr  Ala Gly Glu Ala Leu  Thr Leu Asp 
    1445                 1450                 1455             


Ile Asn  Arg Glu Thr Arg Arg  Tyr His Cys Ser Gly  Lys Asp Gln 
    1460                 1465                 1470             


Ile Val  Pro Ser Leu Asn Thr  Glu Ser Ser Asn Pro  Val Leu Lys 
    1475                 1480                 1485             


Lys Leu  Glu Lys Leu Asn Thr  Glu Lys Glu Glu Arg  Gln Lys Gln 
    1490                 1495                 1500             


Leu Gln  Gln Gln Asn Glu Lys  Glu Met Met Glu Gln  Ile Arg Gln 
    1505                 1510                 1515             


Gln Thr  Asp Ile Leu Glu Lys  Glu Arg Lys Ala Phe  Lys Thr Ile 
    1520                 1525                 1530             


Glu Lys  Pro Arg Ile Gly Glu  Cys Leu Val Ala Pro  Ser Ser Tyr 
    1535                 1540                 1545             


Gln Ser  Lys Gln Arg Val Glu  Arg Pro Ser Ser Leu  Leu Ser Leu 
    1550                 1555                 1560             


Asn Thr  Ser Asn Lys Gly Glu  Leu Asn Val Leu Gly  Ser Leu Ser 
    1565                 1570                 1575             


Leu Lys  Asp Ala Ala Leu Ala  Gln Lys Asp Ser Ser  Ser Ala His 
    1580                 1585                 1590             


Leu Pro  Pro Lys Asp Arg Pro  Val Thr Val Phe Phe  Glu Arg Lys 
    1595                 1600                 1605             


Gly Ser  Pro Cys Gln Ser Ser  Thr Val Lys Glu Leu  Ser Lys Thr 
    1610                 1615                 1620             


Asp Arg  Met Gly Thr Gln Leu  Asn Val Ala Cys Lys  Leu Ser Asn 
    1625                 1630                 1635             


Asn Arg  Ile Ser Lys Arg Glu  His Phe Arg Pro Thr  Gln Ser Tyr 
    1640                 1645                 1650             


Ser His  Asn Ser Asp Asp Leu  Ser Arg Glu Gly Asn  Ala Arg Pro 
    1655                 1660                 1665             


Ile Phe  Phe Thr Pro Lys Asp  Asn Met Ser Ile Pro  Leu Val Ser 
    1670                 1675                 1680             


Lys Glu  Ala Leu Asn Ser Lys  Asn Pro Gln Leu His  Lys Glu Asp 
    1685                 1690                 1695             


Glu Pro  Ala Trp Lys Pro Val  Lys Leu Ala Gly Pro  Gly Gln Arg 
    1700                 1705                 1710             


Glu Thr  Ser Gln Arg Phe Ser  Ser Val Asp Glu Gln  Ala Lys Leu 
    1715                 1720                 1725             


His Lys  Thr Met Ser Gln Gly  Glu Ile Thr Lys Leu  Ala Val Arg 
    1730                 1735                 1740             


Gln Lys  Ala Ser Asp Ser Asp  Ile Arg Pro Gln Arg  Ala Lys Met 
    1745                 1750                 1755             


Arg Phe  Trp Ala Lys Gly Lys  Gln Gly Glu Lys Lys  Thr Thr Arg 
    1760                 1765                 1770             


Val Lys  Pro Thr Thr Gln Ser  Glu Val Ser Pro Leu  Phe Ala Gly 
    1775                 1780                 1785             


Thr Asp  Val Ile Pro Ala His  Gln Phe Pro Asp Glu  Leu Ala Ala 
    1790                 1795                 1800             


Tyr His  Pro Thr Pro Pro Leu  Ser Pro Glu Leu Pro  Gly Ser Cys 
    1805                 1810                 1815             


Arg Lys  Glu Phe Lys Glu Asn  Lys Glu Pro Ser Pro  Lys Ala Lys 
    1820                 1825                 1830             


Arg Lys  Arg Ser Val Lys Ile  Ser Asn Val Ala Leu  Asp Ser Met 
    1835                 1840                 1845             


His Trp  Gln Asn Asp Ser Val  Gln Ile Ile Ala Ser  Val Ser Asp 
    1850                 1855                 1860             


Leu Lys  Ser Met Asp Glu Phe  Leu Leu Lys Lys Val  Asn Asp Leu 
    1865                 1870                 1875             


Asp Asn  Glu Asp Ser Lys Lys  Asp Thr Leu Val Asp  Val Val Phe 
    1880                 1885                 1890             


Lys Lys  Ala Leu Lys Glu Phe  Arg Gln Asn Ile Phe  Ser Phe Tyr 
    1895                 1900                 1905             


Ser Ser  Ala Leu Ala Met Asp  Asp Gly Lys Ser Ile  Arg Tyr Lys 
    1910                 1915                 1920             


Asp Leu  Tyr Ala Leu Phe Glu  Gln Ile Leu Glu Lys  Thr Met Arg 
    1925                 1930                 1935             


Leu Glu  Gln Arg Asp Ser Leu  Gly Glu Ser Pro Val  Arg Val Trp 
    1940                 1945                 1950             


Val Asn  Thr Phe Lys Val Phe  Leu Asp Glu Tyr Met  Asn Glu Phe 
    1955                 1960                 1965             


Lys Thr  Ser Asp Cys Thr Ala  Thr Lys Val Pro Lys  Thr Glu Arg 
    1970                 1975                 1980             


Lys Lys  Arg Arg Lys Lys Glu  Thr Asp Leu Val Glu  Glu His Asn 
    1985                 1990                 1995             


Gly His  Ile Phe Lys Ala Thr  Gln Tyr Ser Ile Pro  Thr Tyr Cys 
    2000                 2005                 2010             


Glu Tyr  Cys Ser Ser Leu Ile  Trp Ile Met Asp Arg  Ala Ser Val 
    2015                 2020                 2025             


Cys Lys  Leu Cys Lys Tyr Ala  Cys His Lys Lys Cys  Cys Leu Lys 
    2030                 2035                 2040             


Thr Thr  Ala Lys Cys Ser Lys  Lys Tyr Asp Pro Glu  Leu Ser Ser 
    2045                 2050                 2055             


Arg Gln  Phe Gly Val Glu Leu  Ser Arg Leu Thr Ser  Glu Asp Arg 
    2060                 2065                 2070             


Thr Val  Pro Leu Val Val Glu  Lys Leu Ile Asn Tyr  Ile Glu Met 
    2075                 2080                 2085             


His Gly  Leu Tyr Thr Glu Gly  Ile Tyr Arg Lys Ser  Gly Ser Thr 
    2090                 2095                 2100             


Asn Lys  Ile Lys Glu Leu Arg  Gln Gly Leu Asp Thr  Asp Ala Glu 
    2105                 2110                 2115             


Ser Val  Asn Leu Asp Asp Tyr  Asn Ile His Val Ile  Ala Ser Val 
    2120                 2125                 2130             


Phe Lys  Gln Trp Leu Arg Asp  Leu Pro Asn Pro Leu  Met Thr Phe 
    2135                 2140                 2145             


Glu Leu  Tyr Glu Glu Phe Leu  Arg Ala Met Gly Leu  Gln Glu Arg 
    2150                 2155                 2160             


Lys Glu  Thr Ile Arg Gly Val  Tyr Ser Val Ile Asp  Gln Leu Ser 
    2165                 2170                 2175             


Arg Thr  His Leu Asn Thr Leu  Glu Arg Leu Ile Phe  His Leu Val 
    2180                 2185                 2190             


Arg Ile  Ala Leu Gln Glu Asp  Thr Asn Arg Met Ser  Ala Asn Ala 
    2195                 2200                 2205             


Leu Ala  Ile Val Phe Ala Pro  Cys Ile Leu Arg Cys  Pro Asp Thr 
    2210                 2215                 2220             


Thr Asp  Pro Leu Gln Ser Val  Gln Asp Ile Ser Lys  Thr Thr Thr 
    2225                 2230                 2235             


Cys Val  Glu Leu Ile Val Val  Glu Gln Met Asn Lys  Tyr Lys Ala 
    2240                 2245                 2250             


Arg Leu  Lys Asp Ile Ser Ser  Leu Glu Phe Ala Glu  Asn Lys Ala 
    2255                 2260                 2265             


Lys Thr  Arg Leu Ser Leu Ile  Arg Arg Ser Met Gly  Lys Gly Arg 
    2270                 2275                 2280             


Ile Arg  Arg Gly Asn Tyr Pro  Gly Pro Ser Ser Pro  Val Val Val 
    2285                 2290                 2295             


Arg Leu  Pro Ser Val Ser Asp  Val Ser Glu Glu Thr  Leu Thr Ser 
    2300                 2305                 2310             


Glu Ala  Ala Met Glu Thr Asp  Ile Thr Glu Gln Gln  Gln Ala Ala 
    2315                 2320                 2325             


Met Gln  Gln Glu Glu Arg Val  Leu Thr Glu Gln Ile  Glu Asn Leu 
    2330                 2335                 2340             


Gln Lys  Glu Lys Glu Glu Leu  Thr Phe Glu Met Leu  Val Leu Glu 
    2345                 2350                 2355             


Pro Arg  Ala Ser Asp Asp Glu  Thr Leu Glu Ser Glu  Ala Ser Ile 
    2360                 2365                 2370             


Gly Thr  Ala Asp Ser Ser Glu  Asn Leu Asn Met Glu  Ser Glu Tyr 
    2375                 2380                 2385             


Ala Ile  Ser Glu Lys Ser Glu  Arg Ser Leu Ala Leu  Ser Ser Leu 
    2390                 2395                 2400             


Lys Thr  Ala Gly Lys Ser Glu  Pro Ser Ser Lys Leu  Arg Lys Gln 
    2405                 2410                 2415             


Leu Lys  Lys Gln Gln Asp Ser  Leu Asp Val Val Asp  Ser Ser Val 
    2420                 2425                 2430             


Ser Ser  Leu Cys Leu Ser Asn  Thr Ala Ser Ser His  Gly Thr Arg 
    2435                 2440                 2445             


Lys Leu  Phe Gln Ile Tyr Ser  Lys Ser Pro Phe Tyr  Arg Ala Ala 
    2450                 2455                 2460             


Ser Gly  Asn Glu Ala Leu Gly  Met Glu Gly Pro Leu  Gly Gln Thr 
    2465                 2470                 2475             


Lys Phe  Leu Glu Asp Lys Pro  Gln Phe Ile Ser Arg  Gly Thr Phe 
    2480                 2485                 2490             


Asn Pro  Glu Lys Gly Lys Gln  Lys Leu Lys Asn Val  Lys Asn Ser 
    2495                 2500                 2505             


Pro Gln  Lys Thr Lys Glu Thr  Pro Glu Gly Thr Val  Met Ser Gly 
    2510                 2515                 2520             


Arg Arg  Lys Thr Val Asp Pro  Asp Cys Thr Ser Asn  Gln Gln Leu 
    2525                 2530                 2535             


Ala Leu  Phe Gly Asn Asn Glu  Phe Met Val 
    2540                 2545             


<210>  1505
<211>  790
<212>  PRT
<213>  homo sapiens

<400>  1505

Met Ser Arg Arg Arg His Ser Asp Glu Asn Asp Gly Gly Gln Pro His 
1               5                   10                  15      


Lys Arg Arg Lys Thr Ser Asp Ala Asn Glu Thr Glu Asp His Leu Glu 
            20                  25                  30          


Ser Leu Ile Cys Lys Val Gly Glu Lys Ser Ala Cys Ser Leu Glu Ser 
        35                  40                  45              


Asn Leu Glu Gly Leu Ala Gly Val Leu Glu Ala Asp Leu Pro Asn Tyr 
    50                  55                  60                  


Lys Ser Lys Ile Leu Arg Leu Leu Cys Thr Val Ala Arg Leu Leu Pro 
65                  70                  75                  80  


Glu Lys Leu Thr Ile Tyr Thr Thr Leu Val Gly Leu Leu Asn Ala Arg 
                85                  90                  95      


Asn Tyr Asn Phe Gly Gly Glu Phe Val Glu Ala Met Ile Arg Gln Leu 
            100                 105                 110         


Lys Glu Ser Leu Lys Ala Asn Asn Tyr Asn Glu Ala Val Tyr Leu Val 
        115                 120                 125             


Arg Phe Leu Ser Asp Leu Val Asn Cys His Val Ile Ala Ala Pro Ser 
    130                 135                 140                 


Met Val Ala Met Phe Glu Asn Phe Val Ser Val Thr Gln Glu Glu Asp 
145                 150                 155                 160 


Val Pro Gln Val Arg Arg Asp Trp Tyr Val Tyr Ala Phe Leu Ser Ser 
                165                 170                 175     


Leu Pro Trp Val Gly Lys Glu Leu Tyr Glu Lys Lys Asp Ala Glu Met 
            180                 185                 190         


Asp Arg Ile Phe Ala Asn Thr Glu Ser Tyr Leu Lys Arg Arg Gln Lys 
        195                 200                 205             


Thr His Val Pro Met Leu Gln Val Trp Thr Ala Asp Lys Pro His Pro 
    210                 215                 220                 


Gln Glu Glu Tyr Leu Asp Cys Leu Trp Ala Gln Ile Gln Lys Leu Lys 
225                 230                 235                 240 


Lys Asp Arg Trp Gln Glu Arg His Ile Leu Arg Pro Tyr Leu Ala Phe 
                245                 250                 255     


Asp Ser Ile Leu Cys Glu Ala Leu Gln His Asn Leu Pro Pro Phe Thr 
            260                 265                 270         


Pro Pro Pro His Thr Glu Asp Ser Val Tyr Pro Met Pro Arg Val Ile 
        275                 280                 285             


Phe Arg Met Phe Asp Tyr Thr Asp Asp Pro Glu Gly Pro Val Met Pro 
    290                 295                 300                 


Gly Ser His Ser Val Glu Arg Phe Val Ile Glu Glu Asn Leu His Cys 
305                 310                 315                 320 


Ile Ile Lys Ser His Trp Lys Glu Arg Lys Thr Cys Ala Ala Gln Leu 
                325                 330                 335     


Val Ser Tyr Pro Gly Lys Asn Lys Ile Pro Leu Asn Tyr His Ile Val 
            340                 345                 350         


Glu Val Ile Phe Ala Glu Leu Phe Gln Leu Pro Ala Pro Pro His Ile 
        355                 360                 365             


Asp Val Met Tyr Thr Thr Leu Leu Ile Glu Leu Cys Lys Leu Gln Pro 
    370                 375                 380                 


Gly Ser Leu Pro Gln Val Leu Ala Gln Ala Thr Glu Met Leu Tyr Met 
385                 390                 395                 400 


Arg Leu Asp Thr Met Asn Thr Thr Cys Val Asp Arg Phe Ile Asn Trp 
                405                 410                 415     


Phe Ser His His Leu Ser Asn Phe Gln Phe Arg Trp Ser Trp Glu Asp 
            420                 425                 430         


Trp Ser Asp Cys Leu Ser Gln Asp Pro Glu Ser Pro Lys Pro Lys Phe 
        435                 440                 445             


Val Arg Glu Val Leu Glu Lys Cys Met Arg Leu Ser Tyr His Gln Arg 
    450                 455                 460                 


Ile Leu Asp Ile Val Pro Pro Thr Phe Ser Ala Leu Cys Pro Ala Asn 
465                 470                 475                 480 


Pro Thr Cys Ile Tyr Lys Tyr Gly Asp Glu Ser Ser Asn Ser Leu Pro 
                485                 490                 495     


Gly His Ser Val Ala Leu Cys Leu Ala Val Ala Phe Lys Ser Lys Ala 
            500                 505                 510         


Thr Asn Asp Glu Ile Phe Ser Ile Leu Lys Asp Val Pro Asn Pro Asn 
        515                 520                 525             


Gln Asp Asp Asp Asp Asp Glu Gly Phe Ser Phe Asn Pro Leu Lys Ile 
    530                 535                 540                 


Glu Val Phe Val Gln Thr Leu Leu His Leu Ala Ala Lys Ser Phe Ser 
545                 550                 555                 560 


His Ser Phe Ser Ala Leu Ala Lys Phe His Glu Val Phe Lys Thr Leu 
                565                 570                 575     


Ala Glu Ser Asp Glu Gly Lys Leu His Val Leu Arg Val Met Phe Glu 
            580                 585                 590         


Val Trp Arg Asn His Pro Gln Met Ile Ala Val Leu Val Asp Lys Met 
        595                 600                 605             


Ile Arg Thr Gln Ile Val Asp Cys Ala Ala Val Ala Asn Trp Ile Phe 
    610                 615                 620                 


Ser Ser Glu Leu Ser Arg Asp Phe Thr Arg Leu Phe Val Trp Glu Ile 
625                 630                 635                 640 


Leu His Ser Thr Ile Arg Lys Met Asn Lys His Val Leu Lys Ile Gln 
                645                 650                 655     


Lys Glu Leu Glu Glu Ala Lys Glu Lys Leu Ala Arg Gln His Lys Arg 
            660                 665                 670         


Arg Ser Asp Asp Asp Asp Arg Ser Ser Asp Arg Lys Asp Gly Val Leu 
        675                 680                 685             


Glu Glu Gln Ile Glu Arg Leu Gln Glu Lys Val Glu Ser Ala Gln Ser 
    690                 695                 700                 


Glu Gln Lys Asn Leu Phe Leu Val Ile Phe Gln Arg Phe Ile Met Ile 
705                 710                 715                 720 


Leu Thr Glu His Leu Val Arg Cys Glu Thr Asp Gly Thr Ser Val Leu 
                725                 730                 735     


Thr Pro Trp Tyr Lys Asn Cys Ile Glu Arg Leu Gln Gln Ile Phe Leu 
            740                 745                 750         


Gln His His Gln Ile Ile Gln Gln Tyr Met Val Thr Leu Glu Asn Leu 
        755                 760                 765             


Leu Phe Thr Ala Glu Leu Asp Pro His Ile Leu Ala Val Phe Gln Gln 
    770                 775                 780                 


Phe Cys Ala Leu Gln Ala 
785                 790 


<210>  1506
<211>  1258
<212>  PRT
<213>  homo sapiens

<400>  1506

Met Glu Lys Tyr Val Arg Leu Gln Lys Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Lys Ala Ile Leu Val Lys Ser Thr Glu Asp Gly Arg Gln Tyr Val Ile 
            20                  25                  30          


Lys Glu Ile Asn Ile Ser Arg Met Ser Ser Lys Glu Arg Glu Glu Ser 
        35                  40                  45              


Arg Arg Glu Val Ala Val Leu Ala Asn Met Lys His Pro Asn Ile Val 
    50                  55                  60                  


Gln Tyr Arg Glu Ser Phe Glu Glu Asn Gly Ser Leu Tyr Ile Val Met 
65                  70                  75                  80  


Asp Tyr Cys Glu Gly Gly Asp Leu Phe Lys Arg Ile Asn Ala Gln Lys 
                85                  90                  95      


Gly Val Leu Phe Gln Glu Asp Gln Ile Leu Asp Trp Phe Val Gln Ile 
            100                 105                 110         


Cys Leu Ala Leu Lys His Val His Asp Arg Lys Ile Leu His Arg Asp 
        115                 120                 125             


Ile Lys Ser Gln Asn Ile Phe Leu Thr Lys Asp Gly Thr Val Gln Leu 
    130                 135                 140                 


Gly Asp Phe Gly Ile Ala Arg Val Leu Asn Ser Thr Val Glu Leu Ala 
145                 150                 155                 160 


Arg Thr Cys Ile Gly Thr Pro Tyr Tyr Leu Ser Pro Glu Ile Cys Glu 
                165                 170                 175     


Asn Lys Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ala Leu Gly Cys Val 
            180                 185                 190         


Leu Tyr Glu Leu Cys Thr Leu Lys His Ala Phe Glu Ala Gly Ser Met 
        195                 200                 205             


Lys Asn Leu Val Leu Lys Ile Ile Ser Gly Ser Phe Pro Pro Val Ser 
    210                 215                 220                 


Leu His Tyr Ser Tyr Asp Leu Arg Ser Leu Val Ser Gln Leu Phe Lys 
225                 230                 235                 240 


Arg Asn Pro Arg Asp Arg Pro Ser Val Asn Ser Ile Leu Glu Lys Gly 
                245                 250                 255     


Phe Ile Ala Lys Arg Ile Glu Lys Phe Leu Ser Pro Gln Leu Ile Ala 
            260                 265                 270         


Glu Glu Phe Cys Leu Lys Thr Phe Ser Lys Phe Gly Ser Gln Pro Ile 
        275                 280                 285             


Pro Ala Lys Arg Pro Ala Ser Gly Gln Asn Ser Ile Ser Val Met Pro 
    290                 295                 300                 


Ala Gln Lys Ile Thr Lys Pro Ala Ala Lys Tyr Gly Ile Pro Leu Ala 
305                 310                 315                 320 


Tyr Lys Lys Tyr Gly Asp Lys Lys Leu His Glu Lys Lys Pro Leu Gln 
                325                 330                 335     


Lys His Lys Gln Ala His Gln Thr Pro Glu Lys Arg Val Asn Thr Gly 
            340                 345                 350         


Glu Glu Arg Arg Lys Ile Ser Glu Glu Ala Ala Arg Lys Arg Arg Leu 
        355                 360                 365             


Glu Phe Ile Glu Lys Glu Lys Lys Gln Lys Asp Gln Ile Ile Ser Leu 
    370                 375                 380                 


Met Lys Ala Glu Gln Met Lys Arg Gln Glu Lys Glu Arg Leu Glu Arg 
385                 390                 395                 400 


Ile Asn Arg Ala Arg Glu Gln Gly Trp Arg Asn Val Leu Ser Ala Gly 
                405                 410                 415     


Gly Ser Gly Glu Val Lys Ala Pro Phe Leu Gly Ser Gly Gly Thr Ile 
            420                 425                 430         


Ala Pro Ser Ser Phe Ser Ser Arg Gly Gln Tyr Glu His Tyr His Ala 
        435                 440                 445             


Ile Phe Asp Gln Met Gln Gln Gln Arg Ala Glu Asp Asn Glu Ala Lys 
    450                 455                 460                 


Trp Lys Arg Glu Ile Tyr Gly Arg Gly Leu Pro Glu Arg Gly Ile Leu 
465                 470                 475                 480 


Pro Gly Val Arg Pro Gly Phe Pro Tyr Gly Ala Ala Gly His His His 
                485                 490                 495     


Phe Pro Asp Ala Asp Asp Ile Arg Lys Thr Leu Lys Arg Leu Lys Ala 
            500                 505                 510         


Val Ser Lys Gln Ala Asn Ala Asn Arg Gln Lys Gly Gln Leu Ala Val 
        515                 520                 525             


Glu Arg Ala Lys Gln Val Glu Glu Phe Leu Gln Arg Lys Arg Glu Ala 
    530                 535                 540                 


Met Gln Asn Lys Ala Arg Ala Glu Gly His Met Val Tyr Leu Ala Arg 
545                 550                 555                 560 


Leu Arg Gln Ile Arg Leu Gln Asn Phe Asn Glu Arg Gln Gln Ile Lys 
                565                 570                 575     


Ala Lys Leu Arg Gly Glu Lys Lys Glu Ala Asn His Ser Glu Gly Gln 
            580                 585                 590         


Glu Gly Ser Glu Glu Ala Asp Met Arg Arg Lys Lys Ile Glu Ser Leu 
        595                 600                 605             


Lys Ala His Ala Asn Ala Arg Ala Ala Val Leu Lys Glu Gln Leu Glu 
    610                 615                 620                 


Arg Lys Arg Lys Glu Ala Tyr Glu Arg Glu Lys Lys Val Trp Glu Glu 
625                 630                 635                 640 


His Leu Val Ala Lys Gly Val Lys Ser Ser Asp Val Ser Pro Pro Leu 
                645                 650                 655     


Gly Gln His Glu Thr Gly Gly Ser Pro Ser Lys Gln Gln Met Arg Ser 
            660                 665                 670         


Val Ile Ser Val Thr Ser Ala Leu Lys Glu Val Gly Val Asp Ser Ser 
        675                 680                 685             


Leu Thr Asp Thr Arg Glu Thr Ser Glu Glu Met Gln Lys Thr Asn Asn 
    690                 695                 700                 


Ala Ile Ser Ser Lys Arg Glu Ile Leu Arg Arg Leu Asn Glu Asn Leu 
705                 710                 715                 720 


Lys Ala Gln Glu Asp Glu Lys Gly Lys Gln Asn Leu Ser Asp Thr Phe 
                725                 730                 735     


Glu Ile Asn Val His Glu Asp Ala Lys Glu His Glu Lys Glu Lys Ser 
            740                 745                 750         


Val Ser Ser Asp Arg Lys Lys Trp Glu Ala Gly Gly Gln Leu Val Ile 
        755                 760                 765             


Pro Leu Asp Glu Leu Thr Leu Asp Thr Ser Phe Ser Thr Thr Glu Arg 
    770                 775                 780                 


His Thr Val Gly Glu Val Ile Lys Leu Gly Pro Asn Gly Ser Pro Arg 
785                 790                 795                 800 


Arg Ala Trp Gly Lys Ser Pro Thr Asp Ser Val Leu Lys Ile Leu Gly 
                805                 810                 815     


Glu Ala Glu Leu Gln Leu Gln Thr Glu Leu Leu Glu Asn Thr Thr Ile 
            820                 825                 830         


Arg Ser Glu Ile Ser Pro Glu Gly Glu Lys Tyr Lys Pro Leu Ile Thr 
        835                 840                 845             


Gly Glu Lys Lys Val Gln Cys Ile Ser His Glu Ile Asn Pro Ser Ala 
    850                 855                 860                 


Ile Val Asp Ser Pro Val Glu Thr Lys Ser Pro Glu Phe Ser Glu Ala 
865                 870                 875                 880 


Ser Pro Gln Met Ser Leu Lys Leu Glu Gly Asn Leu Glu Glu Pro Asp 
                885                 890                 895     


Asp Leu Glu Thr Glu Ile Leu Gln Glu Pro Ser Gly Thr Asn Lys Asp 
            900                 905                 910         


Glu Ser Leu Pro Cys Thr Ile Thr Asp Val Trp Ile Ser Glu Glu Lys 
        915                 920                 925             


Glu Thr Lys Glu Thr Gln Ser Ala Asp Arg Ile Thr Ile Gln Glu Asn 
    930                 935                 940                 


Glu Val Ser Glu Asp Gly Val Ser Ser Thr Val Asp Gln Leu Ser Asp 
945                 950                 955                 960 


Ile His Ile Glu Pro Gly Thr Asn Asp Ser Gln His Ser Lys Cys Asp 
                965                 970                 975     


Val Asp Lys Ser Val Gln Pro Glu Pro Phe Phe His Lys Val Val His 
            980                 985                 990         


Ser Glu His Leu Asn Leu Val Pro  Gln Val Gln Ser Val  Gln Cys Ser 
        995                 1000                 1005             


Pro Glu  Glu Ser Phe Ala Phe  Arg Ser His Ser His  Leu Pro Pro 
    1010                 1015                 1020             


Lys Asn  Lys Asn Lys Asn Ser  Leu Leu Ile Gly Leu  Ser Thr Gly 
    1025                 1030                 1035             


Leu Phe  Asp Ala Asn Asn Pro  Lys Met Leu Arg Thr  Cys Ser Leu 
    1040                 1045                 1050             


Pro Asp  Leu Ser Lys Leu Phe  Arg Thr Leu Met Asp  Val Pro Thr 
    1055                 1060                 1065             


Val Gly  Asp Val Arg Gln Asp  Asn Leu Glu Ile Asp  Glu Ile Glu 
    1070                 1075                 1080             


Asp Glu  Asn Ile Lys Glu Gly  Pro Ser Asp Ser Glu  Asp Ile Val 
    1085                 1090                 1095             


Phe Glu  Glu Thr Asp Thr Asp  Leu Gln Glu Leu Gln  Ala Ser Met 
    1100                 1105                 1110             


Glu Gln  Leu Leu Arg Glu Gln  Pro Gly Glu Glu Tyr  Ser Glu Glu 
    1115                 1120                 1125             


Glu Glu  Ser Val Leu Lys Asn  Ser Asp Val Glu Pro  Thr Ala Asn 
    1130                 1135                 1140             


Gly Thr  Asp Val Ala Asp Glu  Asp Asp Asn Pro Ser  Ser Glu Ser 
    1145                 1150                 1155             


Ala Leu  Asn Glu Glu Trp His  Ser Asp Asn Ser Asp  Gly Glu Ile 
    1160                 1165                 1170             


Ala Ser  Glu Cys Glu Cys Asp  Ser Val Phe Asn His  Leu Glu Glu 
    1175                 1180                 1185             


Leu Arg  Leu His Leu Glu Gln  Glu Met Gly Phe Glu  Lys Phe Phe 
    1190                 1195                 1200             


Glu Val  Tyr Glu Lys Ile Lys  Ala Ile His Glu Asp  Glu Asp Glu 
    1205                 1210                 1215             


Asn Ile  Glu Ile Cys Ser Lys  Ile Val Gln Asn Ile  Leu Gly Asn 
    1220                 1225                 1230             


Glu His  Gln His Leu Tyr Ala  Lys Ile Leu His Leu  Val Met Ala 
    1235                 1240                 1245             


Asp Gly  Ala Tyr Gln Glu Asp  Asn Asp Glu 
    1250                 1255             


<210>  1507
<211>  1120
<212>  PRT
<213>  homo sapiens

<400>  1507

Met Ala Glu Ala Pro Pro Val Ser Gly Thr Phe Lys Phe Asn Thr Asp 
1               5                   10                  15      


Ala Ala Glu Phe Ile Pro Gln Glu Lys Lys Asn Ser Gly Leu Asn Cys 
            20                  25                  30          


Gly Thr Gln Arg Arg Leu Asp Ser Asn Arg Ile Gly Arg Arg Asn Tyr 
        35                  40                  45              


Ser Ser Pro Pro Pro Cys His Leu Ser Arg Gln Val Pro Tyr Asp Glu 
    50                  55                  60                  


Ile Ser Ala Val His Gln His Ser Tyr His Pro Ser Gly Ser Lys Pro 
65                  70                  75                  80  


Lys Ser Gln Gln Thr Ser Phe Gln Ser Ser Pro Cys Asn Lys Ser Pro 
                85                  90                  95      


Lys Ser His Gly Leu Gln Asn Gln Pro Trp Gln Lys Leu Arg Asn Glu 
            100                 105                 110         


Lys His His Ile Arg Val Lys Lys Ala Gln Ser Leu Ala Glu Gln Thr 
        115                 120                 125             


Ser Asp Thr Ala Gly Leu Glu Ser Ser Thr Arg Ser Glu Ser Gly Thr 
    130                 135                 140                 


Asp Leu Arg Glu His Ser Pro Ser Glu Ser Glu Lys Glu Val Val Gly 
145                 150                 155                 160 


Ala Asp Pro Arg Gly Ala Lys Pro Lys Lys Ala Thr Gln Phe Val Tyr 
                165                 170                 175     


Ser Tyr Gly Arg Gly Pro Lys Val Lys Gly Lys Leu Lys Cys Glu Trp 
            180                 185                 190         


Ser Asn Arg Thr Thr Pro Lys Pro Glu Asp Ala Gly Pro Glu Ser Thr 
        195                 200                 205             


Lys Pro Val Gly Val Phe His Pro Asp Ser Ser Glu Ala Ser Ser Arg 
    210                 215                 220                 


Lys Gly Val Leu Asp Gly Tyr Gly Ala Arg Arg Asn Glu Gln Arg Arg 
225                 230                 235                 240 


Tyr Pro Gln Lys Arg Pro Pro Trp Glu Val Glu Gly Ala Arg Pro Arg 
                245                 250                 255     


Pro Gly Arg Asn Pro Pro Lys Gln Glu Gly His Arg His Thr Asn Ala 
            260                 265                 270         


Gly His Arg Asn Asn Met Gly Pro Ile Pro Lys Asp Asp Leu Asn Glu 
        275                 280                 285             


Arg Pro Ala Lys Ser Thr Cys Asp Ser Glu Asn Leu Ala Val Ile Asn 
    290                 295                 300                 


Lys Ser Ser Arg Arg Val Asp Gln Glu Lys Cys Thr Val Arg Arg Gln 
305                 310                 315                 320 


Asp Pro Gln Val Val Ser Pro Phe Ser Arg Gly Lys Gln Asn His Val 
                325                 330                 335     


Leu Lys Asn Val Glu Thr His Thr Gly Ser Leu Ile Glu Gln Leu Thr 
            340                 345                 350         


Thr Glu Lys Tyr Glu Cys Met Val Cys Cys Glu Leu Val Arg Val Thr 
        355                 360                 365             


Ala Pro Val Trp Ser Cys Gln Ser Cys Tyr His Val Phe His Leu Asn 
    370                 375                 380                 


Cys Ile Lys Lys Trp Ala Arg Ser Pro Ala Ser Gln Ala Asp Gly Gln 
385                 390                 395                 400 


Ser Gly Trp Arg Cys Pro Ala Cys Gln Asn Val Ser Ala His Val Pro 
                405                 410                 415     


Asn Thr Tyr Thr Cys Phe Cys Gly Lys Val Lys Asn Pro Glu Trp Ser 
            420                 425                 430         


Arg Asn Glu Ile Pro His Ser Cys Gly Glu Val Cys Arg Lys Lys Gln 
        435                 440                 445             


Pro Gly Gln Asp Cys Pro His Ser Cys Asn Leu Leu Cys His Pro Gly 
    450                 455                 460                 


Pro Cys Pro Pro Cys Pro Ala Phe Met Thr Lys Thr Cys Glu Cys Gly 
465                 470                 475                 480 


Arg Thr Arg His Thr Val Arg Cys Gly Gln Ala Val Ser Val His Cys 
                485                 490                 495     


Ser Asn Pro Cys Glu Asn Ile Leu Asn Cys Gly Gln His Gln Cys Ala 
            500                 505                 510         


Glu Leu Cys His Gly Gly Gln Cys Gln Pro Cys Gln Ile Ile Leu Asn 
        515                 520                 525             


Gln Val Cys Tyr Cys Gly Ser Thr Ser Arg Asp Val Leu Cys Gly Thr 
    530                 535                 540                 


Asp Val Gly Lys Ser Asp Gly Phe Gly Asp Phe Ser Cys Leu Lys Ile 
545                 550                 555                 560 


Cys Gly Lys Asp Leu Lys Cys Gly Asn His Thr Cys Ser Gln Val Cys 
                565                 570                 575     


His Pro Gln Pro Cys Gln Gln Cys Pro Arg Leu Pro Gln Leu Val Arg 
            580                 585                 590         


Cys Cys Pro Cys Gly Gln Thr Pro Leu Ser Gln Leu Leu Glu Leu Gly 
        595                 600                 605             


Ser Ser Ser Arg Lys Thr Cys Met Asp Pro Val Pro Ser Cys Gly Lys 
    610                 615                 620                 


Val Cys Gly Lys Pro Leu Pro Cys Gly Ser Leu Asp Phe Ile His Thr 
625                 630                 635                 640 


Cys Glu Lys Leu Cys His Glu Gly Asp Cys Gly Pro Cys Ser Arg Thr 
                645                 650                 655     


Ser Val Ile Ser Cys Arg Cys Ser Phe Arg Thr Lys Glu Leu Pro Cys 
            660                 665                 670         


Thr Ser Leu Lys Ser Glu Asp Ala Thr Phe Met Cys Asp Lys Arg Cys 
        675                 680                 685             


Asn Lys Lys Arg Leu Cys Gly Arg His Lys Cys Asn Glu Ile Cys Cys 
    690                 695                 700                 


Val Asp Lys Glu His Lys Cys Pro Leu Ile Cys Gly Arg Lys Leu Arg 
705                 710                 715                 720 


Cys Gly Leu His Arg Cys Glu Glu Pro Cys His Arg Gly Asn Cys Gln 
                725                 730                 735     


Thr Cys Trp Gln Ala Ser Phe Asp Glu Leu Thr Cys His Cys Gly Ala 
            740                 745                 750         


Ser Val Ile Tyr Pro Pro Val Pro Cys Gly Thr Arg Pro Pro Glu Cys 
        755                 760                 765             


Thr Gln Thr Cys Ala Arg Val His Glu Cys Asp His Pro Val Tyr His 
    770                 775                 780                 


Ser Cys His Ser Glu Glu Lys Cys Pro Pro Cys Thr Phe Leu Thr Gln 
785                 790                 795                 800 


Lys Trp Cys Met Gly Lys His Glu Phe Arg Ser Asn Ile Pro Cys His 
                805                 810                 815     


Leu Val Asp Ile Ser Cys Gly Leu Pro Cys Ser Ala Thr Leu Pro Cys 
            820                 825                 830         


Gly Met His Lys Cys Gln Arg Leu Cys His Lys Gly Glu Cys Leu Val 
        835                 840                 845             


Asp Glu Pro Cys Lys Gln Pro Cys Thr Thr Pro Arg Ala Asp Cys Gly 
    850                 855                 860                 


His Pro Cys Met Ala Pro Cys His Thr Ser Ser Pro Cys Pro Val Thr 
865                 870                 875                 880 


Ala Cys Lys Ala Lys Val Glu Leu Gln Cys Glu Cys Gly Arg Arg Lys 
                885                 890                 895     


Glu Met Val Ile Cys Ser Glu Ala Ser Ser Thr Tyr Gln Arg Ile Ala 
            900                 905                 910         


Ala Ile Ser Met Ala Ser Lys Ile Thr Asp Met Gln Leu Gly Gly Ser 
        915                 920                 925             


Val Glu Ile Ser Lys Leu Ile Thr Lys Lys Glu Val His Gln Ala Arg 
    930                 935                 940                 


Leu Glu Cys Asp Glu Glu Cys Ser Ala Leu Glu Arg Lys Lys Arg Leu 
945                 950                 955                 960 


Ala Glu Ala Phe His Ile Ser Glu Asp Ser Asp Pro Phe Asn Ile Arg 
                965                 970                 975     


Ser Ser Gly Ser Lys Phe Ser Asp Ser Leu Lys Glu Asp Ala Arg Lys 
            980                 985                 990         


Asp Leu Lys Phe Val Ser Asp Val  Glu Lys Glu Met Glu  Thr Leu Val 
        995                 1000                 1005             


Glu Ala  Val Asn Lys Gly Lys  Asn Ser Lys Lys Ser  His Ser Phe 
    1010                 1015                 1020             


Pro Pro  Met Asn Arg Asp His  Arg Arg Ile Ile His  Asp Leu Ala 
    1025                 1030                 1035             


Gln Val  Tyr Gly Leu Glu Ser  Val Ser Tyr Asp Ser  Glu Pro Lys 
    1040                 1045                 1050             


Arg Asn  Val Val Val Thr Ala  Ile Arg Gly Lys Ser  Val Cys Pro 
    1055                 1060                 1065             


Pro Thr  Thr Leu Thr Gly Val  Leu Glu Arg Glu Met  Gln Ala Arg 
    1070                 1075                 1080             


Pro Pro  Pro Pro Ile Pro His  His Arg His Gln Ser  Asp Lys Asn 
    1085                 1090                 1095             


Pro Gly  Ser Ser Asn Leu Gln  Lys Ile Thr Lys Glu  Pro Ile Ile 
    1100                 1105                 1110             


Asp Tyr  Phe Asp Val Gln Asp  
    1115                 1120 


<210>  1508
<211>  311
<212>  PRT
<213>  homo sapiens

<400>  1508

Met Ala Ala Leu Gly Val Leu Glu Ser Asp Leu Pro Ser Ala Val Thr 
1               5                   10                  15      


Leu Leu Lys Asn Leu Gln Glu Gln Val Met Ala Val Thr Ala Gln Val 
            20                  25                  30          


Lys Ser Leu Thr Gln Lys Val Gln Ala Gly Ala Tyr Pro Thr Glu Lys 
        35                  40                  45              


Gly Leu Ser Phe Leu Glu Val Lys Asp Gln Leu Leu Leu Met Tyr Leu 
    50                  55                  60                  


Met Asp Leu Thr His Leu Ile Leu Asp Lys Ala Ser Gly Gly Ser Leu 
65                  70                  75                  80  


Gln Gly His Asp Ala Val Leu Arg Leu Val Glu Ile Arg Thr Val Leu 
                85                  90                  95      


Glu Lys Leu Arg Pro Leu Asp Gln Lys Leu Lys Tyr Gln Ile Asp Lys 
            100                 105                 110         


Leu Ile Lys Thr Ala Val Thr Gly Ser Leu Ser Glu Asn Asp Pro Leu 
        115                 120                 125             


Arg Phe Lys Pro His Pro Ser Asn Met Met Ser Lys Leu Ser Ser Glu 
    130                 135                 140                 


Asp Glu Glu Glu Asp Glu Ala Glu Asp Asp Gln Ser Glu Ala Ser Gly 
145                 150                 155                 160 


Lys Lys Ser Val Lys Gly Val Ser Lys Lys Tyr Val Pro Pro Arg Leu 
                165                 170                 175     


Val Pro Val His Tyr Asp Glu Thr Glu Ala Glu Arg Glu Lys Lys Arg 
            180                 185                 190         


Leu Glu Arg Ala Lys Arg Arg Ala Leu Ser Ser Ser Val Ile Arg Glu 
        195                 200                 205             


Leu Lys Glu Gln Tyr Ser Asp Ala Pro Glu Glu Ile Arg Asp Ala Arg 
    210                 215                 220                 


His Pro His Val Thr Arg Gln Ser Gln Glu Asp Gln His Arg Ile Asn 
225                 230                 235                 240 


Tyr Glu Glu Ser Met Met Val Arg Leu Ser Val Ser Lys Arg Glu Lys 
                245                 250                 255     


Gly Arg Arg Lys Arg Ala Asn Val Met Ser Ser Gln Leu His Ser Leu 
            260                 265                 270         


Thr His Phe Ser Asp Ile Ser Ala Leu Thr Gly Gly Thr Val His Leu 
        275                 280                 285             


Asp Glu Asp Gln Asn Pro Ile Lys Lys Arg Lys Lys Ile Pro Gln Lys 
    290                 295                 300                 


Gly Arg Lys Lys Lys Gly Gln 
305                 310     


<210>  1509
<211>  180
<212>  PRT
<213>  homo sapiens

<400>  1509

Met Arg Pro Leu Thr Glu Glu Glu Thr Arg Val Met Phe Glu Lys Ile 
1               5                   10                  15      


Ala Lys Tyr Ile Gly Glu Asn Leu Gln Leu Leu Val Asp Arg Pro Asp 
            20                  25                  30          


Gly Thr Tyr Cys Phe Arg Leu His Asn Asp Arg Val Tyr Tyr Val Ser 
        35                  40                  45              


Glu Lys Ile Met Lys Leu Ala Ala Asn Ile Ser Gly Asp Lys Leu Val 
    50                  55                  60                  


Ser Leu Gly Thr Cys Phe Gly Lys Phe Thr Lys Thr His Lys Phe Arg 
65                  70                  75                  80  


Leu His Val Thr Ala Leu Asp Tyr Leu Ala Pro Tyr Ala Lys Tyr Lys 
                85                  90                  95      


Val Trp Ile Lys Pro Gly Ala Glu Gln Ser Phe Leu Tyr Gly Asn His 
            100                 105                 110         


Val Leu Lys Ser Gly Leu Gly Arg Ile Thr Glu Asn Thr Ser Gln Tyr 
        115                 120                 125             


Gln Gly Val Val Val Tyr Ser Met Ala Asp Ile Pro Leu Gly Phe Gly 
    130                 135                 140                 


Val Ala Ala Lys Ser Thr Gln Asp Cys Arg Lys Val Asp Pro Met Ala 
145                 150                 155                 160 


Ile Val Val Phe His Gln Ala Asp Ile Gly Glu Tyr Val Arg His Glu 
                165                 170                 175     


Glu Thr Leu Thr 
            180 


<210>  1510
<211>  688
<212>  PRT
<213>  homo sapiens

<400>  1510

Met Gln Val Ser Ser Leu Asn Glu Val Lys Ile Tyr Ser Leu Ser Cys 
1               5                   10                  15      


Gly Lys Ser Leu Pro Glu Trp Leu Ser Asp Arg Lys Lys Arg Ala Leu 
            20                  25                  30          


Gln Lys Lys Asp Val Asp Val Arg Arg Arg Ile Glu Leu Ile Gln Asp 
        35                  40                  45              


Phe Glu Met Pro Thr Val Cys Thr Thr Ile Lys Val Ser Lys Asp Gly 
    50                  55                  60                  


Gln Tyr Ile Leu Ala Thr Gly Thr Tyr Lys Pro Arg Val Arg Cys Tyr 
65                  70                  75                  80  


Asp Thr Tyr Gln Leu Ser Leu Lys Phe Glu Arg Cys Leu Asp Ser Glu 
                85                  90                  95      


Val Val Thr Phe Glu Ile Leu Ser Asp Asp Tyr Ser Lys Ile Val Phe 
            100                 105                 110         


Leu His Asn Asp Arg Tyr Ile Glu Phe His Ser Gln Ser Gly Phe Tyr 
        115                 120                 125             


Tyr Lys Thr Arg Ile Pro Lys Phe Gly Arg Asp Phe Ser Tyr His Tyr 
    130                 135                 140                 


Pro Ser Cys Asp Leu Tyr Phe Val Gly Ala Ser Ser Glu Val Tyr Arg 
145                 150                 155                 160 


Leu Asn Leu Glu Gln Gly Arg Tyr Leu Asn Pro Leu Gln Thr Asp Ala 
                165                 170                 175     


Ala Glu Asn Asn Val Cys Asp Ile Asn Ser Val His Gly Leu Phe Ala 
            180                 185                 190         


Thr Gly Thr Ile Glu Gly Arg Val Glu Cys Trp Asp Pro Arg Thr Arg 
        195                 200                 205             


Asn Arg Val Gly Leu Leu Asp Cys Ala Leu Asn Ser Val Thr Ala Asp 
    210                 215                 220                 


Ser Glu Ile Asn Ser Leu Pro Thr Ile Ser Ala Leu Lys Phe Asn Gly 
225                 230                 235                 240 


Ala Leu Thr Met Ala Val Gly Thr Thr Thr Gly Gln Val Leu Leu Tyr 
                245                 250                 255     


Asp Leu Arg Ser Asp Lys Pro Leu Leu Val Lys Asp His Gln Tyr Gly 
            260                 265                 270         


Leu Pro Ile Lys Ser Val His Phe Gln Asp Ser Leu Asp Leu Ile Leu 
        275                 280                 285             


Ser Ala Asp Ser Arg Ile Val Lys Met Trp Asn Lys Asn Ser Gly Lys 
    290                 295                 300                 


Ile Phe Thr Ser Leu Glu Pro Glu His Asp Leu Asn Asp Val Cys Leu 
305                 310                 315                 320 


Tyr Pro Asn Ser Gly Met Leu Leu Thr Ala Asn Glu Thr Pro Lys Met 
                325                 330                 335     


Gly Ile Tyr Tyr Ile Pro Val Leu Gly Pro Ala Pro Arg Trp Cys Ser 
            340                 345                 350         


Phe Leu Asp Asn Leu Thr Glu Glu Leu Glu Glu Asn Pro Glu Ser Thr 
        355                 360                 365             


Val Tyr Asp Asp Tyr Lys Phe Val Thr Lys Lys Asp Leu Glu Asn Leu 
    370                 375                 380                 


Gly Leu Thr His Leu Ile Gly Ser Pro Phe Leu Arg Ala Tyr Met His 
385                 390                 395                 400 


Gly Phe Phe Met Asp Ile Arg Leu Tyr His Lys Val Lys Leu Met Val 
                405                 410                 415     


Asn Pro Phe Ala Tyr Glu Glu Tyr Arg Lys Asp Lys Ile Arg Gln Lys 
            420                 425                 430         


Ile Glu Glu Thr Arg Ala Gln Arg Val Gln Leu Lys Lys Leu Pro Lys 
        435                 440                 445             


Val Asn Lys Glu Leu Ala Leu Lys Leu Ile Glu Glu Glu Glu Glu Lys 
    450                 455                 460                 


Gln Lys Ser Thr Trp Lys Lys Lys Val Lys Ser Leu Pro Asn Ile Leu 
465                 470                 475                 480 


Thr Asp Asp Arg Phe Lys Val Met Phe Glu Asn Pro Asp Phe Gln Val 
                485                 490                 495     


Asp Glu Glu Ser Glu Glu Phe Arg Leu Leu Asn Pro Leu Val Ser Lys 
            500                 505                 510         


Ile Ser Glu Lys Arg Lys Lys Lys Leu Arg Leu Leu Glu Gln Gln Glu 
        515                 520                 525             


Leu Arg Glu Lys Glu Glu Glu Glu Glu Pro Glu Gly Lys Pro Ser Asp 
    530                 535                 540                 


Ala Glu Ser Ser Glu Ser Ser Asp Asp Glu Lys Ala Trp Val Glu Glu 
545                 550                 555                 560 


Val Arg Lys Gln Arg Arg Leu Leu Gln Gln Glu Glu Lys Val Lys Arg 
                565                 570                 575     


Gln Glu Arg Leu Lys Glu Asp Gln Gln Thr Val Leu Lys Pro Gln Phe 
            580                 585                 590         


Tyr Glu Ile Lys Ala Gly Glu Glu Phe Arg Ser Phe Lys Asp Ser Ala 
        595                 600                 605             


Thr Lys Gln Lys Leu Met Asn Lys Thr Leu Glu Asp Arg Leu Lys Ile 
    610                 615                 620                 


Glu Ala Lys Asn Gly Thr Leu Ser Val Ser Asp Thr Thr Val Gly Ser 
625                 630                 635                 640 


Lys Gln Leu Thr Phe Thr Leu Lys Arg Ser Glu Gln Gln Lys Lys Gln 
                645                 650                 655     


Gln Glu Ala Glu Lys Leu His Arg Gln Glu Arg Lys Arg Leu Arg Arg 
            660                 665                 670         


Ser Ala Gly His Leu Lys Ser Arg His Lys Arg Gly Arg Ser Phe His 
        675                 680                 685             


<210>  1511
<211>  1167
<212>  PRT
<213>  homo sapiens

<400>  1511

Met Lys Val Asn Arg Glu Thr Lys Arg Leu Tyr Val Gly Gly Leu Ser 
1               5                   10                  15      


Gln Asp Ile Ser Glu Ala Asp Leu Gln Asn Gln Phe Ser Arg Phe Gly 
            20                  25                  30          


Glu Val Ser Asp Val Glu Ile Ile Thr Arg Lys Asp Asp Gln Gly Asn 
        35                  40                  45              


Pro Gln Lys Val Phe Ala Tyr Ile Asn Ile Ser Val Ala Glu Ala Asp 
    50                  55                  60                  


Leu Lys Lys Cys Met Ser Val Leu Asn Lys Thr Lys Trp Lys Gly Gly 
65                  70                  75                  80  


Thr Leu Gln Ile Gln Leu Ala Lys Glu Ser Phe Leu His Arg Leu Ala 
                85                  90                  95      


Gln Glu Arg Glu Ala Ala Lys Ala Lys Lys Glu Glu Ser Thr Thr Gly 
            100                 105                 110         


Asn Ala Asn Leu Leu Glu Lys Thr Gly Gly Val Asp Phe His Met Lys 
        115                 120                 125             


Ala Val Pro Gly Thr Glu Val Pro Gly His Lys Asn Trp Val Val Ser 
    130                 135                 140                 


Lys Phe Gly Arg Val Leu Pro Val Leu His Leu Lys Asn Gln His Lys 
145                 150                 155                 160 


Arg Lys Ile Ile Lys Tyr Asp Pro Ser Lys Tyr Cys His Asn Leu Lys 
                165                 170                 175     


Lys Ile Gly Glu Asp Phe Ser Asn Thr Ile Pro Ile Ser Ser Leu Thr 
            180                 185                 190         


Trp Glu Leu Glu Gly Gly Asn Asp Pro Met Ser Lys Lys Arg Arg Gly 
        195                 200                 205             


Glu Phe Ser Asp Phe His Gly Pro Pro Lys Lys Ile Ile Lys Val Gln 
    210                 215                 220                 


Lys Asp Glu Ser Ser Thr Gly Ser Leu Ala Met Ser Thr Arg Pro Arg 
225                 230                 235                 240 


Arg Val Ile Glu Arg Pro Pro Leu Thr Gln Gln Gln Ala Ala Gln Lys 
                245                 250                 255     


Arg Thr Cys Asp Ser Ile Thr Pro Ser Lys Ser Ser Pro Val Pro Val 
            260                 265                 270         


Ser Asp Thr Gln Lys Leu Lys Asn Leu Pro Phe Lys Thr Ser Gly Leu 
        275                 280                 285             


Glu Thr Ala Lys Lys Arg Asn Ser Ile Ser Asp Asp Asp Thr Asp Ser 
    290                 295                 300                 


Glu Asp Glu Leu Arg Met Met Ile Ala Lys Glu Glu Asn Leu Gln Arg 
305                 310                 315                 320 


Thr Thr Gln Pro Ser Ile Asn Glu Ser Glu Ser Asp Pro Phe Glu Val 
                325                 330                 335     


Val Arg Asp Asp Phe Lys Ser Gly Val His Lys Leu His Ser Leu Ile 
            340                 345                 350         


Gly Leu Gly Ile Lys Asn Arg Val Ser Cys His Asp Ser Asp Asp Asp 
        355                 360                 365             


Ile Met Arg Asn Asp Arg Glu Tyr Asp Ser Gly Asp Thr Asp Glu Ile 
    370                 375                 380                 


Ile Ala Met Lys Lys Asn Val Ala Lys Val Lys Asn Ser Thr Glu Phe 
385                 390                 395                 400 


Ser Gln Met Glu Lys Ser Thr Lys Lys Thr Ser Phe Lys Asn Arg Glu 
                405                 410                 415     


Asn Cys Glu Leu Ser Asp His Cys Ile Lys Leu Gln Lys Arg Lys Ser 
            420                 425                 430         


Asn Val Glu Ser Ala Leu Ser His Gly Leu Lys Ser Leu Asn Arg Lys 
        435                 440                 445             


Ser Pro Ser His Ser Ser Ser Ser Glu Asp Ala Asp Ser Ala Ser Glu 
    450                 455                 460                 


Leu Ala Asp Ser Glu Gly Gly Glu Glu Tyr Asn Ala Met Met Lys Asn 
465                 470                 475                 480 


Cys Leu Arg Val Asn Leu Thr Leu Ala Asp Leu Glu Gln Leu Ala Gly 
                485                 490                 495     


Ser Asp Leu Lys Val Pro Asn Glu Asp Thr Lys Ser Asp Gly Pro Glu 
            500                 505                 510         


Thr Thr Thr Gln Cys Lys Phe Asp Arg Gly Ser Lys Ser Pro Lys Thr 
        515                 520                 525             


Pro Thr Gly Leu Arg Arg Gly Arg Gln Cys Ile Arg Pro Ala Glu Ile 
    530                 535                 540                 


Val Ala Ser Leu Leu Glu Gly Glu Glu Asn Thr Cys Gly Lys Gln Lys 
545                 550                 555                 560 


Pro Lys Glu Asn Asn Leu Lys Pro Lys Phe Gln Ala Phe Lys Gly Val 
                565                 570                 575     


Gly Cys Leu Tyr Glu Lys Glu Ser Met Lys Lys Ser Leu Lys Asp Ser 
            580                 585                 590         


Val Ala Ser Asn Asn Lys Asp Gln Asn Ser Met Lys His Glu Asp Pro 
        595                 600                 605             


Ser Ile Ile Ser Met Glu Asp Gly Ser Pro Tyr Val Asn Gly Ser Leu 
    610                 615                 620                 


Gly Glu Val Thr Pro Cys Gln His Ala Lys Lys Ala Asn Gly Pro Asn 
625                 630                 635                 640 


Tyr Ile Gln Pro Gln Lys Arg Gln Thr Thr Phe Glu Ser Gln Asp Arg 
                645                 650                 655     


Lys Ala Val Ser Pro Ser Ser Ser Glu Lys Arg Ser Lys Asn Pro Ile 
            660                 665                 670         


Ser Arg Pro Leu Glu Gly Lys Lys Ser Leu Ser Leu Ser Ala Lys Thr 
        675                 680                 685             


His Asn Ile Gly Phe Asp Lys Asp Ser Cys His Ser Thr Thr Lys Thr 
    690                 695                 700                 


Glu Ala Ser Gln Glu Glu Arg Ser Asp Ser Ser Gly Leu Thr Ser Leu 
705                 710                 715                 720 


Lys Lys Ser Pro Lys Val Ser Ser Lys Asp Thr Arg Glu Ile Lys Thr 
                725                 730                 735     


Asp Phe Ser Leu Ser Ile Ser Asn Ser Ser Asp Val Ser Ala Lys Asp 
            740                 745                 750         


Lys His Ala Glu Asp Asn Glu Lys Arg Leu Ala Ala Leu Glu Ala Arg 
        755                 760                 765             


Gln Lys Ala Lys Glu Val Gln Lys Lys Leu Val His Asn Ala Leu Ala 
    770                 775                 780                 


Asn Leu Asp Gly His Pro Glu Asp Lys Pro Thr His Ile Ile Phe Gly 
785                 790                 795                 800 


Ser Asp Ser Glu Cys Glu Thr Glu Glu Thr Ser Thr Gln Glu Gln Ser 
                805                 810                 815     


His Pro Gly Glu Glu Trp Val Lys Glu Ser Met Gly Lys Thr Ser Gly 
            820                 825                 830         


Lys Leu Phe Asp Ser Ser Asp Asp Asp Glu Ser Asp Ser Glu Asp Asp 
        835                 840                 845             


Ser Asn Arg Phe Lys Ile Lys Pro Gln Phe Glu Gly Arg Ala Gly Gln 
    850                 855                 860                 


Lys Leu Met Asp Leu Gln Ser His Phe Gly Thr Asp Asp Arg Phe Arg 
865                 870                 875                 880 


Met Asp Ser Arg Phe Leu Glu Thr Asp Ser Glu Glu Glu Gln Glu Glu 
                885                 890                 895     


Val Asn Glu Lys Lys Thr Ala Glu Glu Glu Glu Leu Ala Glu Glu Lys 
            900                 905                 910         


Lys Lys Ala Leu Asn Val Val Gln Ser Val Leu Gln Ile Asn Leu Ser 
        915                 920                 925             


Asn Ser Thr Asn Arg Gly Ser Val Ala Ala Lys Lys Phe Lys Asp Ile 
    930                 935                 940                 


Ile His Tyr Asp Pro Thr Lys Gln Asp His Ala Thr Tyr Glu Arg Lys 
945                 950                 955                 960 


Arg Asp Asp Lys Pro Lys Glu Ser Lys Ala Lys Arg Lys Lys Lys Arg 
                965                 970                 975     


Glu Glu Ala Glu Lys Leu Pro Glu Val Ser Lys Glu Met Tyr Tyr Asn 
            980                 985                 990         


Ile Ala Met Asp Leu Lys Glu Ile  Phe Gln Thr Thr Lys  Tyr Thr Ser 
        995                 1000                 1005             


Glu Lys  Glu Glu Gly Thr Pro  Trp Asn Glu Asp Cys  Gly Lys Glu 
    1010                 1015                 1020             


Lys Pro  Glu Glu Ile Gln Asp  Pro Ala Ala Leu Thr  Ser Asp Ala 
    1025                 1030                 1035             


Glu Gln  Pro Ser Gly Phe Thr  Phe Ser Phe Phe Asp  Ser Asp Thr 
    1040                 1045                 1050             


Lys Asp  Ile Lys Glu Glu Thr  Tyr Arg Val Glu Thr  Val Lys Pro 
    1055                 1060                 1065             


Gly Lys  Ile Val Trp Gln Glu  Asp Pro Arg Leu Gln  Asp Ser Ser 
    1070                 1075                 1080             


Ser Glu  Glu Glu Asp Val Thr  Glu Glu Thr Asp His  Arg Asn Ser 
    1085                 1090                 1095             


Ser Pro  Gly Glu Ala Ser Leu  Leu Glu Lys Glu Thr  Thr Arg Phe 
    1100                 1105                 1110             


Phe Phe  Phe Ser Lys Asn Asp  Glu Arg Leu Gln Gly  Ser Asp Leu 
    1115                 1120                 1125             


Phe Trp  Arg Gly Val Gly Ser  Asn Met Ser Arg Asn  Ser Trp Glu 
    1130                 1135                 1140             


Ala Arg  Thr Thr Asn Leu Arg  Met Asp Cys Arg Lys  Lys His Lys 
    1145                 1150                 1155             


Asp Ala  Lys Arg Lys Met Lys  Pro Lys 
    1160                 1165         


<210>  1512
<211>  2471
<212>  PRT
<213>  homo sapiens

<400>  1512

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  1513
<211>  603
<212>  PRT
<213>  homo sapiens

<400>  1513

Met Ala Thr Ile Glu Glu Ile Ala His Gln Ile Ile Glu Gln Gln Met 
1               5                   10                  15      


Gly Glu Ile Val Thr Glu Gln Gln Thr Gly Gln Lys Ile Gln Ile Val 
            20                  25                  30          


Thr Ala Leu Asp His Asn Thr Gln Gly Lys Gln Phe Ile Leu Thr Asn 
        35                  40                  45              


His Asp Gly Ser Thr Pro Ser Lys Val Ile Leu Ala Arg Gln Asp Ser 
    50                  55                  60                  


Thr Pro Gly Lys Val Phe Leu Thr Thr Pro Asp Ala Ala Gly Val Asn 
65                  70                  75                  80  


Gln Leu Phe Phe Thr Thr Pro Asp Leu Ser Ala Gln His Leu Gln Leu 
                85                  90                  95      


Leu Thr Asp Asn Ser Pro Asp Gln Gly Pro Asn Lys Val Phe Asp Leu 
            100                 105                 110         


Cys Val Val Cys Gly Asp Lys Ala Ser Gly Arg His Tyr Gly Ala Val 
        115                 120                 125             


Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Ser Ile Arg Lys Asn 
    130                 135                 140                 


Leu Val Tyr Ser Cys Arg Gly Ser Lys Asp Cys Ile Ile Asn Lys His 
145                 150                 155                 160 


His Arg Asn Arg Cys Gln Tyr Cys Arg Leu Gln Arg Cys Ile Ala Phe 
                165                 170                 175     


Gly Met Lys Gln Asp Ser Val Gln Cys Glu Arg Lys Pro Ile Glu Val 
            180                 185                 190         


Ser Arg Glu Lys Ser Ser Asn Cys Ala Ala Ser Thr Glu Lys Ile Tyr 
        195                 200                 205             


Ile Arg Lys Asp Leu Arg Ser Pro Leu Thr Ala Thr Pro Thr Phe Val 
    210                 215                 220                 


Thr Asp Ser Glu Ser Thr Arg Ser Thr Gly Leu Leu Asp Ser Gly Met 
225                 230                 235                 240 


Phe Met Asn Ile His Pro Ser Gly Val Lys Thr Glu Ser Ala Val Leu 
                245                 250                 255     


Met Thr Ser Asp Lys Ala Glu Ser Cys Gln Gly Asp Leu Ser Thr Leu 
            260                 265                 270         


Ala Asn Val Val Thr Ser Leu Ala Asn Leu Gly Lys Thr Lys Asp Leu 
        275                 280                 285             


Ser Gln Asn Ser Asn Glu Met Ser Met Ile Glu Ser Leu Ser Asn Asp 
    290                 295                 300                 


Asp Thr Ser Leu Cys Glu Phe Gln Glu Met Gln Thr Asn Gly Asp Val 
305                 310                 315                 320 


Ser Arg Ala Phe Asp Thr Leu Ala Lys Ala Leu Asn Pro Gly Glu Ser 
                325                 330                 335     


Thr Ala Cys Gln Ser Ser Val Ala Gly Met Glu Gly Ser Val His Leu 
            340                 345                 350         


Ile Thr Gly Asp Ser Ser Ile Asn Tyr Thr Glu Lys Glu Gly Pro Leu 
        355                 360                 365             


Leu Ser Asp Ser His Val Ala Phe Arg Leu Thr Met Pro Ser Pro Met 
    370                 375                 380                 


Pro Glu Tyr Leu Asn Val His Tyr Ile Gly Glu Ser Ala Ser Arg Leu 
385                 390                 395                 400 


Leu Phe Leu Ser Met His Trp Ala Leu Ser Ile Pro Ser Phe Gln Ala 
                405                 410                 415     


Leu Gly Gln Glu Asn Ser Ile Ser Leu Val Lys Ala Tyr Trp Asn Glu 
            420                 425                 430         


Leu Phe Thr Leu Gly Leu Ala Gln Cys Trp Gln Val Met Asn Val Ala 
        435                 440                 445             


Thr Ile Leu Ala Thr Phe Val Asn Cys Leu His Asn Ser Leu Gln Gln 
    450                 455                 460                 


Asp Lys Met Ser Thr Glu Arg Arg Lys Leu Leu Met Glu His Ile Phe 
465                 470                 475                 480 


Lys Leu Gln Glu Phe Cys Asn Ser Met Val Lys Leu Cys Ile Asp Gly 
                485                 490                 495     


Tyr Glu Tyr Ala Tyr Leu Lys Ala Ile Val Leu Phe Ser Pro Asp His 
            500                 505                 510         


Pro Ser Leu Glu Asn Met Glu Gln Ile Glu Lys Phe Gln Glu Lys Ala 
        515                 520                 525             


Tyr Val Glu Phe Gln Asp Tyr Ile Thr Lys Thr Tyr Pro Asp Asp Thr 
    530                 535                 540                 


Tyr Arg Leu Ser Arg Leu Leu Leu Arg Leu Pro Ala Leu Arg Leu Met 
545                 550                 555                 560 


Asn Ala Thr Ile Thr Glu Glu Leu Phe Phe Lys Gly Leu Ile Gly Asn 
                565                 570                 575     


Ile Arg Ile Asp Ser Val Ile Pro His Ile Leu Lys Met Glu Pro Ala 
            580                 585                 590         


Asp Tyr Asn Ser Gln Ile Ile Gly His Ser Ile 
        595                 600             


<210>  1514
<211>  418
<212>  PRT
<213>  homo sapiens

<400>  1514

Met Phe Ser Pro Asp Gln Glu Asn His Pro Ser Lys Ala Pro Val Lys 
1               5                   10                  15      


Tyr Gly Glu Leu Ile Val Leu Gly Tyr Asn Gly Ser Leu Pro Asn Gly 
            20                  25                  30          


Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Phe Lys Arg Pro Lys 
        35                  40                  45              


Ala Asn Gly Val Lys Pro Ser Thr Val His Ile Ala Cys Thr Pro Gln 
    50                  55                  60                  


Ala Ala Lys Ala Ile Ser Asn Lys Asp Gln His Ser Ile Ser Tyr Thr 
65                  70                  75                  80  


Leu Ser Arg Ala Gln Thr Val Val Val Glu Tyr Thr His Asp Ser Asn 
                85                  90                  95      


Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Ser Pro Ile Asp Phe 
            100                 105                 110         


Val Val Thr Asp Thr Val Pro Gly Ser Gln Ser Asn Ser Asp Thr Gln 
        115                 120                 125             


Ser Val Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Ile Cys Glu 
    130                 135                 140                 


Arg Asn Pro Pro Phe Thr Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ser 
145                 150                 155                 160 


Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys Thr Ser 
                165                 170                 175     


Asp Gly Gln Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val Met His 
            180                 185                 190         


Pro Arg Asn Gly Phe Thr Glu Asp Ser Lys Pro Gly Ile Trp Arg Glu 
        195                 200                 205             


Ile Ser Val Cys Gly Asn Val Phe Ser Leu Arg Glu Thr Arg Ser Ala 
    210                 215                 220                 


Gln Gln Arg Gly Lys Met Val Glu Ile Glu Thr Asn Gln Leu Gln Asp 
225                 230                 235                 240 


Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg Thr Ala 
                245                 250                 255     


Glu Gly Leu Ser His Thr Pro Thr Val Lys His Leu Glu Ala Leu Arg 
            260                 265                 270         


Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Phe Asn Thr 
        275                 280                 285             


Leu Ala Phe Pro Ser Met Lys Arg Lys Asp Val Val Asp Glu Lys Gln 
    290                 295                 300                 


Pro Trp Val Tyr Leu Asn Cys Gly His Val His Gly Tyr His Asn Trp 
305                 310                 315                 320 


Gly Asn Lys Glu Glu Arg Asp Gly Lys Asp Arg Glu Cys Pro Met Cys 
                325                 330                 335     


Arg Ser Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu Ala Gly 
            340                 345                 350         


Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Ser Pro Cys Gly 
        355                 360                 365             


His Val Cys Ser Glu Lys Thr Thr Ala Tyr Trp Ser Gln Ile Pro Leu 
    370                 375                 380                 


Pro His Gly Thr His Thr Phe His Ala Ala Cys Pro Phe Cys Ala His 
385                 390                 395                 400 


Gln Leu Ala Gly Glu Gln Gly Tyr Ile Arg Leu Ile Phe Gln Gly Pro 
                405                 410                 415     


Leu Asp 
        


<210>  1515
<211>  1283
<212>  PRT
<213>  homo sapiens

<400>  1515

Met Trp Gly Ser Asp Arg Leu Ala Gly Ala Gly Gly Gly Gly Ala Ala 
1               5                   10                  15      


Val Thr Val Ala Phe Thr Asn Ala Arg Asp Cys Phe Leu His Leu Pro 
            20                  25                  30          


Arg Arg Leu Val Ala Gln Leu His Leu Leu Gln Asn Gln Ala Ile Glu 
        35                  40                  45              


Val Val Trp Ser His Gln Pro Ala Phe Leu Ser Trp Val Glu Gly Arg 
    50                  55                  60                  


His Phe Ser Asp Gln Gly Glu Asn Val Ala Glu Ile Asn Arg Gln Val 
65                  70                  75                  80  


Gly Gln Lys Leu Gly Leu Ser Asn Gly Gly Gln Val Phe Leu Lys Pro 
                85                  90                  95      


Cys Ser His Val Val Ser Cys Gln Gln Val Glu Val Glu Pro Leu Ser 
            100                 105                 110         


Ala Asp Asp Trp Glu Ile Leu Glu Leu His Ala Val Ser Leu Glu Gln 
        115                 120                 125             


His Leu Leu Asp Gln Ile Arg Ile Val Phe Pro Lys Ala Ile Phe Pro 
    130                 135                 140                 


Val Trp Val Asp Gln Gln Thr Tyr Ile Phe Ile Gln Ile Val Ala Leu 
145                 150                 155                 160 


Ile Pro Ala Ala Ser Tyr Gly Arg Leu Glu Thr Asp Thr Lys Leu Leu 
                165                 170                 175     


Ile Gln Pro Lys Thr Arg Arg Ala Lys Glu Asn Thr Phe Ser Lys Ala 
            180                 185                 190         


Asp Ala Glu Tyr Lys Lys Leu His Ser Tyr Gly Arg Asp Gln Lys Gly 
        195                 200                 205             


Met Met Lys Glu Leu Gln Thr Lys Gln Leu Gln Ser Asn Thr Val Gly 
    210                 215                 220                 


Ile Thr Glu Ser Asn Glu Asn Glu Ser Glu Ile Pro Val Asp Ser Ser 
225                 230                 235                 240 


Ser Val Ala Ser Leu Trp Thr Met Ile Gly Ser Ile Phe Ser Phe Gln 
                245                 250                 255     


Ser Glu Lys Lys Gln Glu Thr Ser Trp Gly Leu Thr Glu Ile Asn Ala 
            260                 265                 270         


Phe Lys Asn Met Gln Ser Lys Val Val Pro Leu Asp Asn Ile Phe Arg 
        275                 280                 285             


Val Cys Lys Ser Gln Pro Pro Ser Ile Tyr Asn Ala Ser Ala Thr Ser 
    290                 295                 300                 


Val Phe His Lys His Cys Ala Ile His Val Phe Pro Trp Asp Gln Glu 
305                 310                 315                 320 


Tyr Phe Asp Val Glu Pro Ser Phe Thr Val Thr Tyr Gly Lys Leu Val 
                325                 330                 335     


Lys Leu Leu Ser Pro Lys Gln Gln Gln Ser Lys Thr Lys Gln Asn Val 
            340                 345                 350         


Leu Ser Pro Glu Lys Glu Lys Gln Met Ser Glu Pro Leu Asp Gln Lys 
        355                 360                 365             


Lys Ile Arg Ser Asp His Asn Glu Glu Asp Glu Lys Ala Cys Val Leu 
    370                 375                 380                 


Gln Val Val Trp Asn Gly Leu Glu Glu Leu Asn Asn Ala Ile Lys Tyr 
385                 390                 395                 400 


Thr Lys Asn Val Glu Val Leu His Leu Gly Lys Val Trp Ile Pro Asp 
                405                 410                 415     


Asp Leu Arg Lys Arg Leu Asn Ile Glu Met His Ala Val Val Arg Ile 
            420                 425                 430         


Thr Pro Val Glu Val Thr Pro Lys Ile Pro Arg Ser Leu Lys Leu Gln 
        435                 440                 445             


Pro Arg Glu Asn Leu Pro Lys Asp Ile Ser Glu Glu Asp Ile Lys Thr 
    450                 455                 460                 


Val Phe Tyr Ser Trp Leu Gln Gln Ser Thr Thr Thr Met Leu Pro Leu 
465                 470                 475                 480 


Val Ile Ser Glu Glu Glu Phe Ile Lys Leu Glu Thr Lys Asp Gly Leu 
                485                 490                 495     


Lys Glu Phe Ser Leu Ser Ile Val His Ser Trp Glu Lys Glu Lys Asp 
            500                 505                 510         


Lys Asn Ile Phe Leu Leu Ser Pro Asn Leu Leu Gln Lys Thr Thr Ile 
        515                 520                 525             


Gln Val Leu Leu Asp Pro Met Val Lys Glu Glu Asn Ser Glu Glu Ile 
    530                 535                 540                 


Asp Phe Ile Leu Pro Phe Leu Lys Leu Ser Ser Leu Gly Gly Val Asn 
545                 550                 555                 560 


Ser Leu Gly Val Ser Ser Leu Glu His Ile Thr His Ser Leu Leu Gly 
                565                 570                 575     


Arg Pro Leu Ser Arg Gln Leu Met Ser Leu Val Ala Gly Leu Arg Asn 
            580                 585                 590         


Gly Ala Leu Leu Leu Thr Gly Gly Lys Gly Ser Gly Lys Ser Thr Leu 
        595                 600                 605             


Ala Lys Ala Ile Cys Lys Glu Ala Phe Asp Lys Leu Asp Ala His Val 
    610                 615                 620                 


Glu Arg Val Asp Cys Lys Ala Leu Arg Gly Lys Arg Leu Glu Asn Ile 
625                 630                 635                 640 


Gln Lys Thr Leu Glu Val Ala Phe Ser Glu Ala Val Trp Met Gln Pro 
                645                 650                 655     


Ser Val Val Leu Leu Asp Asp Leu Asp Leu Ile Ala Gly Leu Pro Ala 
            660                 665                 670         


Val Pro Glu His Glu His Ser Pro Asp Ala Val Gln Ser Gln Arg Leu 
        675                 680                 685             


Ala His Ala Leu Asn Asp Met Ile Lys Glu Phe Ile Ser Met Gly Ser 
    690                 695                 700                 


Leu Val Ala Leu Ile Ala Thr Ser Gln Ser Gln Gln Ser Leu His Pro 
705                 710                 715                 720 


Leu Leu Val Ser Ala Gln Gly Val His Ile Phe Gln Cys Val Gln His 
                725                 730                 735     


Ile Gln Pro Pro Asn Gln Glu Gln Arg Cys Glu Ile Leu Cys Asn Val 
            740                 745                 750         


Ile Lys Asn Lys Leu Asp Cys Asp Ile Asn Lys Phe Thr Asp Leu Asp 
        755                 760                 765             


Leu Gln His Val Ala Lys Glu Thr Gly Gly Phe Val Ala Arg Asp Phe 
    770                 775                 780                 


Thr Val Leu Val Asp Arg Ala Ile His Ser Arg Leu Ser Arg Gln Ser 
785                 790                 795                 800 


Ile Ser Thr Arg Glu Lys Leu Val Leu Thr Thr Leu Asp Phe Gln Lys 
                805                 810                 815     


Ala Leu Arg Gly Phe Leu Pro Ala Ser Leu Arg Ser Val Asn Leu His 
            820                 825                 830         


Lys Pro Arg Asp Leu Gly Trp Asp Lys Ile Gly Gly Leu His Glu Val 
        835                 840                 845             


Arg Gln Ile Leu Met Asp Thr Ile Gln Leu Pro Ala Lys Tyr Pro Glu 
    850                 855                 860                 


Leu Phe Ala Asn Leu Pro Ile Arg Gln Arg Thr Gly Ile Leu Leu Tyr 
865                 870                 875                 880 


Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Gly Val Ile Ala Arg 
                885                 890                 895     


Glu Ser Arg Met Asn Phe Ile Ser Val Lys Gly Pro Glu Leu Leu Ser 
            900                 905                 910         


Lys Tyr Ile Gly Ala Ser Glu Gln Ala Val Arg Asp Ile Phe Ile Arg 
        915                 920                 925             


Ala Gln Ala Ala Lys Pro Cys Ile Leu Phe Phe Asp Glu Phe Glu Ser 
    930                 935                 940                 


Ile Ala Pro Arg Arg Gly His Asp Asn Thr Gly Val Thr Asp Arg Val 
945                 950                 955                 960 


Val Asn Gln Leu Leu Thr Gln Leu Asp Gly Val Glu Gly Leu Gln Gly 
                965                 970                 975     


Val Tyr Val Leu Ala Ala Thr Ser Arg Pro Asp Leu Ile Asp Pro Ala 
            980                 985                 990         


Leu Leu Arg Pro Gly Arg Leu Asp  Lys Cys Val Tyr Cys  Pro Pro Pro 
        995                 1000                 1005             


Asp Gln  Val Ser Arg Leu Glu  Ile Leu Asn Val Leu  Ser Asp Ser 
    1010                 1015                 1020             


Leu Pro  Leu Ala Asp Asp Val  Asp Leu Gln His Val  Ala Ser Val 
    1025                 1030                 1035             


Thr Asp  Ser Phe Thr Gly Ala  Asp Leu Lys Ala Leu  Leu Tyr Asn 
    1040                 1045                 1050             


Ala Gln  Leu Glu Ala Leu His  Gly Met Leu Leu Ser  Ser Gly Leu 
    1055                 1060                 1065             


Gln Asp  Gly Ser Ser Ser Ser  Asp Ser Asp Leu Ser  Leu Ser Ser 
    1070                 1075                 1080             


Met Val  Phe Leu Asn His Ser  Ser Gly Ser Asp Asp  Ser Ala Gly 
    1085                 1090                 1095             


Asp Gly  Glu Cys Gly Leu Asp  Gln Ser Leu Val Ser  Leu Glu Met 
    1100                 1105                 1110             


Ser Glu  Ile Leu Pro Asp Glu  Ser Lys Phe Asn Met  Tyr Arg Leu 
    1115                 1120                 1125             


Tyr Phe  Gly Ser Ser Tyr Glu  Ser Glu Leu Gly Asn  Gly Thr Ser 
    1130                 1135                 1140             


Ser Asp  Leu Ser Ser Gln Cys  Leu Ser Ala Pro Ser  Ser Met Thr 
    1145                 1150                 1155             


Gln Asp  Leu Pro Gly Val Pro  Gly Lys Asp Gln Leu  Phe Ser Gln 
    1160                 1165                 1170             


Pro Pro  Val Leu Arg Thr Ala  Ser Gln Glu Gly Cys  Gln Glu Leu 
    1175                 1180                 1185             


Thr Gln  Glu Gln Arg Asp Gln  Leu Arg Ala Asp Ile  Ser Ile Ile 
    1190                 1195                 1200             


Lys Gly  Arg Tyr Arg Ser Gln  Ser Gly Glu Asp Glu  Ser Met Asn 
    1205                 1210                 1215             


Gln Pro  Gly Pro Ile Lys Thr  Arg Leu Ala Ile Ser  Gln Ser His 
    1220                 1225                 1230             


Leu Met  Thr Ala Leu Gly His  Thr Arg Pro Ser Ile  Ser Glu Asp 
    1235                 1240                 1245             


Asp Trp  Lys Asn Phe Ala Glu  Leu Tyr Glu Ser Phe  Gln Asn Pro 
    1250                 1255                 1260             


Lys Arg  Arg Lys Asn Gln Ser  Gly Thr Met Phe Arg  Pro Gly Gln 
    1265                 1270                 1275             


Lys Val  Thr Leu Ala 
    1280             


<210>  1516
<211>  995
<212>  PRT
<213>  homo sapiens

<400>  1516

Met Ala Glu Ala Glu Phe Lys Asp His Ser Thr Ala Met Asp Thr Glu 
1               5                   10                  15      


Pro Asn Pro Gly Thr Ser Ser Val Ser Thr Thr Thr Ser Ser Thr Thr 
            20                  25                  30          


Thr Thr Thr Ile Thr Thr Ser Ser Ser Arg Met Gln Gln Pro Gln Ile 
        35                  40                  45              


Ser Val Tyr Ser Gly Ser Asp Arg His Ala Val Gln Val Ile Gln Gln 
    50                  55                  60                  


Ala Leu His Arg Pro Pro Ser Ser Ala Ala Gln Tyr Leu Gln Gln Met 
65                  70                  75                  80  


Tyr Ala Ala Gln Gln Gln His Leu Met Leu His Thr Ala Ala Leu Gln 
                85                  90                  95      


Gln Gln His Leu Ser Ser Ser Gln Leu Gln Ser Leu Ala Ala Val Gln 
            100                 105                 110         


Ala Ser Leu Ser Ser Gly Arg Pro Ser Thr Ser Pro Thr Gly Ser Val 
        115                 120                 125             


Thr Gln Gln Ser Ser Met Ser Gln Thr Ser Ile Asn Leu Ser Thr Ser 
    130                 135                 140                 


Pro Thr Pro Ala Gln Leu Ile Ser Arg Ser Gln Ala Ser Ser Ser Thr 
145                 150                 155                 160 


Ser Gly Ser Ile Thr Gln Gln Thr Met Leu Leu Gly Ser Thr Ser Pro 
                165                 170                 175     


Thr Leu Thr Ala Ser Gln Ala Gln Met Tyr Leu Arg Ala Gln Met Leu 
            180                 185                 190         


Ile Phe Thr Pro Ala Thr Thr Val Ala Ala Val Gln Ser Asp Ile Pro 
        195                 200                 205             


Val Val Ser Ser Ser Ser Ser Ser Ser Cys Gln Ser Ala Ala Thr Gln 
    210                 215                 220                 


Val Gln Asn Leu Thr Leu Arg Ser Gln Lys Leu Gly Val Leu Ser Ser 
225                 230                 235                 240 


Ser Gln Asn Gly Pro Pro Lys Ser Thr Ser Gln Thr Gln Ser Leu Thr 
                245                 250                 255     


Ile Cys His Asn Lys Thr Thr Val Thr Ser Ser Lys Ile Ser Gln Arg 
            260                 265                 270         


Asp Pro Ser Pro Glu Ser Asn Lys Lys Gly Glu Ser Pro Ser Leu Glu 
        275                 280                 285             


Ser Arg Ser Thr Ala Val Thr Arg Thr Ser Ser Ile His Gln Leu Ile 
    290                 295                 300                 


Ala Pro Ala Ser Tyr Ser Pro Ile Gln Pro His Ser Leu Ile Lys His 
305                 310                 315                 320 


Gln Gln Ile Pro Leu His Ser Pro Pro Ser Lys Val Ser His His Gln 
                325                 330                 335     


Leu Ile Leu Gln Gln Gln Gln Gln Gln Ile Gln Pro Ile Thr Leu Gln 
            340                 345                 350         


Asn Ser Thr Gln Asp Pro Pro Pro Ser Gln His Cys Ile Pro Leu Gln 
        355                 360                 365             


Asn His Gly Leu Pro Pro Ala Pro Ser Asn Ala Gln Ser Gln His Cys 
    370                 375                 380                 


Ser Pro Ile Gln Ser His Pro Ser Pro Leu Thr Val Ser Pro Asn Gln 
385                 390                 395                 400 


Ser Gln Ser Ala Gln Gln Ser Val Val Val Ser Pro Pro Pro Pro His 
                405                 410                 415     


Ser Pro Ser Gln Ser Pro Thr Ile Ile Ile His Pro Gln Ala Leu Ile 
            420                 425                 430         


Gln Pro His Pro Leu Val Ser Ser Ala Leu Gln Pro Gly Pro Asn Leu 
        435                 440                 445             


Gln Gln Ser Thr Ala Asn Gln Val Gln Ala Thr Ala Gln Leu Asn Leu 
    450                 455                 460                 


Pro Ser His Leu Pro Leu Pro Ala Ser Pro Val Val His Ile Gly Pro 
465                 470                 475                 480 


Val Gln Gln Ser Ala Leu Val Ser Pro Gly Gln Gln Ile Val Ser Pro 
                485                 490                 495     


Ser His Gln Gln Tyr Ser Ser Leu Gln Ser Ser Pro Ile Pro Ile Ala 
            500                 505                 510         


Ser Pro Pro Gln Met Ser Thr Ser Pro Pro Ala Gln Ile Pro Pro Leu 
        515                 520                 525             


Pro Leu Gln Ser Met Gln Ser Leu Gln Val Gln Pro Glu Ile Leu Ser 
    530                 535                 540                 


Gln Gly Gln Val Leu Val Gln Asn Ala Leu Val Ser Glu Glu Glu Leu 
545                 550                 555                 560 


Pro Ala Ala Glu Ala Leu Val Gln Leu Pro Phe Gln Thr Leu Pro Pro 
                565                 570                 575     


Pro Gln Thr Val Ala Val Asn Leu Gln Val Gln Pro Pro Ala Pro Val 
            580                 585                 590         


Asp Pro Pro Val Val Tyr Gln Val Glu Asp Val Cys Glu Glu Glu Met 
        595                 600                 605             


Pro Glu Glu Ser Asp Glu Cys Val Arg Met Asp Arg Thr Pro Pro Pro 
    610                 615                 620                 


Pro Thr Leu Ser Pro Ala Ala Ile Thr Val Gly Arg Gly Glu Asp Leu 
625                 630                 635                 640 


Thr Ser Glu His Pro Leu Leu Glu Gln Val Glu Leu Pro Ala Val Ala 
                645                 650                 655     


Ser Val Ser Ala Ser Val Ile Lys Ser Pro Ser Asp Pro Ser His Val 
            660                 665                 670         


Ser Val Pro Pro Pro Pro Leu Leu Leu Pro Ala Ala Thr Thr Arg Ser 
        675                 680                 685             


Asn Ser Thr Ser Met His Ser Ser Ile Pro Ser Ile Glu Asn Lys Pro 
    690                 695                 700                 


Pro Gln Ala Ile Val Lys Pro Gln Ile Leu Thr His Val Ile Glu Gly 
705                 710                 715                 720 


Phe Val Ile Gln Glu Gly Leu Glu Pro Phe Pro Val Ser Arg Ser Ser 
                725                 730                 735     


Leu Leu Ile Glu Gln Pro Val Lys Lys Arg Pro Leu Leu Asp Asn Gln 
            740                 745                 750         


Val Ile Asn Ser Val Cys Val Gln Pro Glu Leu Gln Asn Asn Thr Lys 
        755                 760                 765             


His Ala Asp Asn Ser Ser Asp Thr Glu Met Glu Asp Met Ile Ala Glu 
    770                 775                 780                 


Glu Thr Leu Glu Glu Met Asp Ser Glu Leu Leu Lys Cys Glu Phe Cys 
785                 790                 795                 800 


Gly Lys Met Gly Tyr Ala Asn Glu Phe Leu Arg Ser Lys Arg Phe Cys 
                805                 810                 815     


Thr Met Ser Cys Ala Lys Arg Tyr Asn Val Ser Cys Ser Lys Lys Phe 
            820                 825                 830         


Ala Leu Ser Arg Trp Asn Arg Lys Pro Asp Asn Gln Ser Leu Gly His 
        835                 840                 845             


Arg Gly Arg Arg Pro Ser Gly Pro Asp Gly Ala Ala Arg Glu His Ile 
    850                 855                 860                 


Leu Arg Gln Leu Pro Ile Thr Tyr Pro Ser Ala Glu Glu Asp Leu Ala 
865                 870                 875                 880 


Ser His Glu Asp Ser Val Pro Ser Ala Met Thr Thr Arg Leu Arg Arg 
                885                 890                 895     


Gln Ser Glu Arg Glu Arg Glu Arg Glu Leu Arg Asp Val Arg Ile Arg 
            900                 905                 910         


Lys Met Pro Glu Asn Ser Asp Leu Leu Pro Val Ala Gln Thr Glu Pro 
        915                 920                 925             


Ser Ile Trp Thr Val Asp Asp Val Trp Ala Phe Ile His Ser Leu Pro 
    930                 935                 940                 


Gly Cys Gln Asp Ile Ala Asp Glu Phe Arg Ala Gln Glu Ile Asp Gly 
945                 950                 955                 960 


Gln Ala Leu Leu Leu Leu Lys Glu Asp His Leu Met Ser Ala Met Asn 
                965                 970                 975     


Ile Lys Leu Gly Pro Ala Leu Lys Ile Cys Ala Arg Ile Asn Ser Leu 
            980                 985                 990         


Lys Glu Ser 
        995 


<210>  1517
<211>  1001
<212>  PRT
<213>  homo sapiens

<400>  1517

Met Pro Thr Glu Lys Lys Ile Ser Ser Ala Ser Asp Cys Ile Asn Ser 
1               5                   10                  15      


Met Val Glu Gly Ser Glu Leu Lys Lys Val Arg Ser Asn Ser Arg Ile 
            20                  25                  30          


Tyr His Arg Tyr Phe Leu Leu Asp Ala Asp Met Gln Ser Leu Arg Trp 
        35                  40                  45              


Glu Pro Ser Lys Lys Asp Ser Glu Lys Ala Lys Ile Asp Ile Lys Ser 
    50                  55                  60                  


Ile Lys Glu Val Arg Thr Gly Lys Asn Thr Asp Ile Phe Arg Ser Asn 
65                  70                  75                  80  


Gly Ile Ser Asp Gln Ile Ser Glu Asp Cys Ala Phe Ser Val Ile Tyr 
                85                  90                  95      


Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
            100                 105                 110         


Ala Asn Ile Trp Val Thr Gly Leu Arg Tyr Leu Ile Ser Tyr Gly Lys 
        115                 120                 125             


His Thr Leu Asp Met Leu Glu Ser Ser Gln Asp Asn Met Arg Thr Ser 
    130                 135                 140                 


Trp Val Ser Gln Met Phe Ser Glu Ile Asp Val Asp Asn Leu Gly His 
145                 150                 155                 160 


Ile Thr Leu Cys Asn Ala Val Gln Cys Ile Arg Asn Leu Asn Pro Gly 
                165                 170                 175     


Leu Lys Thr Ser Lys Ile Glu Leu Lys Phe Lys Glu Leu His Lys Ser 
            180                 185                 190         


Lys Asp Lys Ala Gly Thr Glu Val Thr Lys Glu Glu Phe Ile Glu Val 
        195                 200                 205             


Phe His Glu Leu Cys Thr Arg Pro Glu Ile Tyr Phe Leu Leu Val Gln 
    210                 215                 220                 


Phe Ser Ser Asn Lys Glu Phe Leu Asp Thr Lys Asp Leu Met Met Phe 
225                 230                 235                 240 


Leu Glu Ala Glu Gln Gly Val Ala His Ile Asn Glu Glu Ile Ser Leu 
                245                 250                 255     


Glu Ile Ile His Lys Tyr Glu Pro Ser Lys Glu Gly Gln Glu Lys Gly 
            260                 265                 270         


Trp Leu Ser Ile Asp Gly Phe Thr Asn Tyr Leu Met Ser Pro Asp Cys 
        275                 280                 285             


Tyr Ile Phe Asp Pro Glu His Lys Lys Val Cys Gln Asp Met Lys Gln 
    290                 295                 300                 


Pro Leu Ser His Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Ile 
305                 310                 315                 320 


Glu Asp Gln Phe Arg Gly Pro Ser Asp Ile Thr Gly Tyr Ile Arg Ala 
                325                 330                 335     


Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Trp Asp Gly Pro 
            340                 345                 350         


Asp Asn Glu Pro Val Ile Tyr Thr Gly His Thr Met Thr Ser Gln Ile 
        355                 360                 365             


Val Phe Arg Ser Val Ile Asp Ile Ile Asn Lys Tyr Ala Phe Phe Ala 
    370                 375                 380                 


Ser Glu Tyr Pro Leu Ile Leu Cys Leu Glu Asn His Cys Ser Ile Lys 
385                 390                 395                 400 


Gln Gln Lys Val Met Val Gln His Met Lys Lys Leu Leu Gly Asp Lys 
                405                 410                 415     


Leu Tyr Thr Thr Ser Pro Asn Val Glu Glu Ser Tyr Leu Pro Ser Pro 
            420                 425                 430         


Asp Val Leu Lys Gly Lys Ile Leu Ile Lys Ala Lys Lys Leu Ser Ser 
        435                 440                 445             


Asn Cys Ser Gly Val Glu Gly Asp Val Thr Asp Glu Asp Glu Gly Ala 
    450                 455                 460                 


Glu Met Ser Gln Arg Met Gly Lys Glu Asn Met Glu Gln Pro Asn Asn 
465                 470                 475                 480 


Val Pro Val Lys Arg Phe Gln Leu Cys Lys Glu Leu Ser Glu Leu Val 
                485                 490                 495     


Ser Ile Cys Lys Ser Val Gln Phe Lys Glu Phe Gln Val Ser Phe Gln 
            500                 505                 510         


Val Gln Lys Tyr Trp Glu Val Cys Ser Phe Asn Glu Val Leu Ala Ser 
        515                 520                 525             


Lys Tyr Ala Asn Glu Asn Pro Gly Asp Phe Val Asn Tyr Asn Lys Arg 
    530                 535                 540                 


Phe Leu Ala Arg Val Phe Pro Ser Pro Met Arg Ile Asp Ser Ser Asn 
545                 550                 555                 560 


Met Asn Pro Gln Asp Phe Trp Lys Cys Gly Cys Gln Ile Val Ala Met 
                565                 570                 575     


Asn Phe Gln Thr Pro Gly Leu Met Met Asp Leu Asn Ile Gly Trp Phe 
            580                 585                 590         


Arg Gln Asn Gly Asn Cys Gly Tyr Val Leu Arg Pro Ala Ile Met Arg 
        595                 600                 605             


Glu Glu Val Ser Phe Phe Ser Ala Asn Thr Lys Asp Ser Val Pro Gly 
    610                 615                 620                 


Val Ser Pro Gln Leu Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe 
625                 630                 635                 640 


Pro Lys Pro Lys Gly Ser Gly Ala Lys Gly Asp Val Val Asp Pro Tyr 
                645                 650                 655     


Val Tyr Val Glu Ile His Gly Ile Pro Ala Asp Cys Ala Glu Gln Arg 
            660                 665                 670         


Thr Lys Thr Val His Gln Asn Gly Asp Ala Pro Ile Phe Asp Glu Ser 
        675                 680                 685             


Phe Glu Phe Gln Ile Asn Leu Pro Glu Leu Ala Met Val Arg Phe Val 
    690                 695                 700                 


Val Leu Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr 
705                 710                 715                 720 


Ile Pro Phe Glu Cys Leu Gln Thr Gly Tyr Arg His Val Pro Leu Gln 
                725                 730                 735     


Ser Leu Thr Gly Glu Val Leu Ala His Ala Ser Leu Phe Val His Val 
            740                 745                 750         


Ala Ile Thr Asn Arg Arg Gly Gly Gly Lys Pro His Lys Arg Gly Leu 
        755                 760                 765             


Ser Val Arg Lys Gly Lys Lys Ser Arg Glu Tyr Ala Ser Leu Arg Thr 
    770                 775                 780                 


Leu Trp Ile Lys Thr Val Asp Glu Val Phe Lys Asn Ala Gln Pro Pro 
785                 790                 795                 800 


Ile Arg Asp Ala Thr Asp Leu Arg Glu Asn Met Gln Asn Ala Val Val 
                805                 810                 815     


Ser Phe Lys Glu Leu Cys Gly Leu Ser Ser Val Ala Asn Leu Met Gln 
            820                 825                 830         


Cys Met Leu Ala Val Ser Pro Arg Phe Leu Gly Pro Asp Asn Thr Pro 
        835                 840                 845             


Leu Val Val Leu Asn Leu Ser Glu Gln Tyr Pro Thr Met Glu Leu Gln 
    850                 855                 860                 


Gly Ile Val Pro Glu Val Leu Lys Lys Ile Val Thr Thr Tyr Asp Met 
865                 870                 875                 880 


Met Ile Gln Ser Leu Lys Ala Leu Ile Glu Asn Ala Asp Ala Val Tyr 
                885                 890                 895     


Glu Lys Ile Val His Cys Gln Lys Ala Ala Met Glu Phe His Glu His 
            900                 905                 910         


Leu His Ser Ile Gly Thr Lys Glu Gly Leu Lys Glu Arg Lys Leu Gln 
        915                 920                 925             


Lys Ala Val Glu Ser Phe Thr Trp Asn Ile Thr Ile Leu Lys Gly Gln 
    930                 935                 940                 


Ala Asp Leu Leu Lys Tyr Ala Lys Asn Glu Thr Leu Glu Asn Leu Lys 
945                 950                 955                 960 


Gln Ile His Phe Ala Ala Val Ser Cys Gly Leu Asn Lys Pro Gly Thr 
                965                 970                 975     


Glu Asn Ala Asp Val Gln Lys Pro Arg Arg Ser Leu Glu Val Ile Pro 
            980                 985                 990         


Glu Lys Ala Asn Asp Glu Thr Gly  Glu 
        995                 1000     


<210>  1518
<211>  1970
<212>  PRT
<213>  homo sapiens

<400>  1518

Met His Gly Gly Gly Pro Pro Ser Gly Asp Ser Ala Cys Pro Leu Arg 
1               5                   10                  15      


Thr Ile Lys Arg Val Gln Phe Gly Val Leu Ser Pro Asp Glu Leu Lys 
            20                  25                  30          


Arg Met Ser Val Thr Glu Gly Gly Ile Lys Tyr Pro Glu Thr Thr Glu 
        35                  40                  45              


Gly Gly Arg Pro Lys Leu Gly Gly Leu Met Asp Pro Arg Gln Gly Val 
    50                  55                  60                  


Ile Glu Arg Thr Gly Arg Cys Gln Thr Cys Ala Gly Asn Met Thr Glu 
65                  70                  75                  80  


Cys Pro Gly His Phe Gly His Ile Glu Leu Ala Lys Pro Val Phe His 
                85                  90                  95      


Val Gly Phe Leu Val Lys Thr Met Lys Val Leu Arg Cys Val Cys Phe 
            100                 105                 110         


Phe Cys Ser Lys Leu Leu Val Asp Ser Asn Asn Pro Lys Ile Lys Asp 
        115                 120                 125             


Ile Leu Ala Lys Ser Lys Gly Gln Pro Lys Lys Arg Leu Thr His Val 
    130                 135                 140                 


Tyr Asp Leu Cys Lys Gly Lys Asn Ile Cys Glu Gly Gly Glu Glu Met 
145                 150                 155                 160 


Asp Asn Lys Phe Gly Val Glu Gln Pro Glu Gly Asp Glu Asp Leu Thr 
                165                 170                 175     


Lys Glu Lys Gly His Gly Gly Cys Gly Arg Tyr Gln Pro Arg Ile Arg 
            180                 185                 190         


Arg Ser Gly Leu Glu Leu Tyr Ala Glu Trp Lys His Val Asn Glu Asp 
        195                 200                 205             


Ser Gln Glu Lys Lys Ile Leu Leu Ser Pro Glu Arg Val His Glu Ile 
    210                 215                 220                 


Phe Lys Arg Ile Ser Asp Glu Glu Cys Phe Val Leu Gly Met Glu Pro 
225                 230                 235                 240 


Arg Tyr Ala Arg Pro Glu Trp Met Ile Val Thr Val Leu Pro Val Pro 
                245                 250                 255     


Pro Leu Ser Val Arg Pro Ala Val Val Met Gln Gly Ser Ala Arg Asn 
            260                 265                 270         


Gln Asp Asp Leu Thr His Lys Leu Ala Asp Ile Val Lys Ile Asn Asn 
        275                 280                 285             


Gln Leu Arg Arg Asn Glu Gln Asn Gly Ala Ala Ala His Val Ile Ala 
    290                 295                 300                 


Glu Asp Val Lys Leu Leu Gln Phe His Val Ala Thr Met Val Asp Asn 
305                 310                 315                 320 


Glu Leu Pro Gly Leu Pro Arg Ala Met Gln Lys Ser Gly Arg Pro Leu 
                325                 330                 335     


Lys Ser Leu Lys Gln Arg Leu Lys Gly Lys Glu Gly Arg Val Arg Gly 
            340                 345                 350         


Asn Leu Met Gly Lys Arg Val Asp Phe Ser Ala Arg Thr Val Ile Thr 
        355                 360                 365             


Pro Asp Pro Asn Leu Ser Ile Asp Gln Val Gly Val Pro Arg Ser Ile 
    370                 375                 380                 


Ala Ala Asn Met Thr Phe Ala Glu Ile Val Thr Pro Phe Asn Ile Asp 
385                 390                 395                 400 


Arg Leu Gln Glu Leu Val Arg Arg Gly Asn Ser Gln Tyr Pro Gly Ala 
                405                 410                 415     


Lys Tyr Ile Ile Arg Asp Asn Gly Asp Arg Ile Asp Leu Arg Phe His 
            420                 425                 430         


Pro Lys Pro Ser Asp Leu His Leu Gln Thr Gly Tyr Lys Val Glu Arg 
        435                 440                 445             


His Met Cys Asp Gly Asp Ile Val Ile Phe Asn Arg Gln Pro Thr Leu 
    450                 455                 460                 


His Lys Met Ser Met Met Gly His Arg Val Arg Ile Leu Pro Trp Ser 
465                 470                 475                 480 


Thr Phe Arg Leu Asn Leu Ser Val Thr Thr Pro Tyr Asn Ala Asp Phe 
                485                 490                 495     


Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Ser Leu Glu Thr Arg 
            500                 505                 510         


Ala Glu Ile Gln Glu Leu Ala Met Val Pro Arg Met Ile Val Thr Pro 
        515                 520                 525             


Gln Ser Asn Arg Pro Val Met Gly Ile Val Gln Asp Thr Leu Thr Ala 
    530                 535                 540                 


Val Arg Lys Phe Thr Lys Arg Asp Val Phe Leu Glu Arg Gly Glu Val 
545                 550                 555                 560 


Met Asn Leu Leu Met Phe Leu Ser Thr Trp Asp Gly Lys Val Pro Gln 
                565                 570                 575     


Pro Ala Ile Leu Lys Pro Arg Pro Leu Trp Thr Gly Lys Gln Ile Phe 
            580                 585                 590         


Ser Leu Ile Ile Pro Gly His Ile Asn Cys Ile Arg Thr His Ser Thr 
        595                 600                 605             


His Pro Asp Asp Glu Asp Ser Gly Pro Tyr Lys His Ile Ser Pro Gly 
    610                 615                 620                 


Asp Thr Lys Val Val Val Glu Asn Gly Glu Leu Ile Met Gly Ile Leu 
625                 630                 635                 640 


Cys Lys Lys Ser Leu Gly Thr Ser Ala Gly Ser Leu Val His Ile Ser 
                645                 650                 655     


Tyr Leu Glu Met Gly His Asp Ile Thr Arg Leu Phe Tyr Ser Asn Ile 
            660                 665                 670         


Gln Thr Val Ile Asn Asn Trp Leu Leu Ile Glu Gly His Thr Ile Gly 
        675                 680                 685             


Ile Gly Asp Ser Ile Ala Asp Ser Lys Thr Tyr Gln Asp Ile Gln Asn 
    690                 695                 700                 


Thr Ile Lys Lys Ala Lys Gln Asp Val Ile Glu Val Ile Glu Lys Ala 
705                 710                 715                 720 


His Asn Asn Glu Leu Glu Pro Thr Pro Gly Asn Thr Leu Arg Gln Thr 
                725                 730                 735     


Phe Glu Asn Gln Val Asn Arg Ile Leu Asn Asp Ala Arg Asp Lys Thr 
            740                 745                 750         


Gly Ser Ser Ala Gln Lys Ser Leu Ser Glu Tyr Asn Asn Phe Lys Ser 
        755                 760                 765             


Met Val Val Ser Gly Ala Lys Gly Ser Lys Ile Asn Ile Ser Gln Val 
    770                 775                 780                 


Ile Ala Val Val Gly Gln Gln Asn Val Glu Gly Lys Arg Ile Pro Phe 
785                 790                 795                 800 


Gly Phe Lys His Arg Thr Leu Pro His Phe Ile Lys Asp Asp Tyr Gly 
                805                 810                 815     


Pro Glu Ser Arg Gly Phe Val Glu Asn Ser Tyr Leu Ala Gly Leu Thr 
            820                 825                 830         


Pro Thr Glu Phe Phe Phe His Ala Met Gly Gly Arg Glu Gly Leu Ile 
        835                 840                 845             


Asp Thr Ala Val Lys Thr Ala Glu Thr Gly Tyr Ile Gln Arg Arg Leu 
    850                 855                 860                 


Ile Lys Ser Met Glu Ser Val Met Val Lys Tyr Asp Ala Thr Val Arg 
865                 870                 875                 880 


Asn Ser Ile Asn Gln Val Val Gln Leu Arg Tyr Gly Glu Asp Gly Leu 
                885                 890                 895     


Ala Gly Glu Ser Val Glu Phe Gln Asn Leu Ala Thr Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Ala Phe Glu Lys Lys Phe Arg Phe Asp Tyr Thr Asn Glu Arg 
        915                 920                 925             


Ala Leu Arg Arg Thr Leu Gln Glu Asp Leu Val Lys Asp Val Leu Ser 
    930                 935                 940                 


Asn Ala His Ile Gln Asn Glu Leu Glu Arg Glu Phe Glu Arg Met Arg 
945                 950                 955                 960 


Glu Asp Arg Glu Val Leu Arg Val Ile Phe Pro Thr Gly Asp Ser Lys 
                965                 970                 975     


Val Val Leu Pro Cys Asn Leu Leu Arg Met Ile Trp Asn Ala Gln Lys 
            980                 985                 990         


Ile Phe His Ile Asn Pro Arg Leu  Pro Ser Asp Leu His  Pro Ile Lys 
        995                 1000                 1005             


Val Val  Glu Gly Val Lys Glu  Leu Ser Lys Lys Leu  Val Ile Val 
    1010                 1015                 1020             


Asn Gly  Asp Asp Pro Leu Ser  Arg Gln Ala Gln Glu  Asn Ala Thr 
    1025                 1030                 1035             


Leu Leu  Phe Asn Ile His Leu  Arg Ser Thr Leu Cys  Ser Arg Arg 
    1040                 1045                 1050             


Met Ala  Glu Glu Phe Arg Leu  Ser Gly Glu Ala Phe  Asp Trp Leu 
    1055                 1060                 1065             


Leu Gly  Glu Ile Glu Ser Lys  Phe Asn Gln Ala Ile  Ala His Pro 
    1070                 1075                 1080             


Gly Glu  Met Val Gly Ala Leu  Ala Ala Gln Ser Leu  Gly Glu Pro 
    1085                 1090                 1095             


Ala Thr  Gln Met Thr Leu Asn  Thr Phe His Tyr Ala  Gly Val Ser 
    1100                 1105                 1110             


Ala Lys  Asn Val Thr Leu Gly  Val Pro Arg Leu Lys  Glu Leu Ile 
    1115                 1120                 1125             


Asn Ile  Ser Lys Lys Pro Lys  Thr Pro Ser Leu Thr  Val Phe Leu 
    1130                 1135                 1140             


Leu Gly  Gln Ser Ala Arg Asp  Ala Glu Arg Ala Lys  Asp Ile Leu 
    1145                 1150                 1155             


Cys Arg  Leu Glu His Thr Thr  Leu Arg Lys Val Thr  Ala Asn Thr 
    1160                 1165                 1170             


Ala Ile  Tyr Tyr Asp Pro Asn  Pro Gln Ser Thr Val  Val Ala Glu 
    1175                 1180                 1185             


Asp Gln  Glu Trp Val Asn Val  Tyr Tyr Glu Met Pro  Asp Phe Asp 
    1190                 1195                 1200             


Val Ala  Arg Ile Ser Pro Trp  Leu Leu Arg Val Glu  Leu Asp Arg 
    1205                 1210                 1215             


Lys His  Met Thr Asp Arg Lys  Leu Thr Met Glu Gln  Ile Ala Glu 
    1220                 1225                 1230             


Lys Ile  Asn Ala Gly Phe Gly  Asp Asp Leu Asn Cys  Ile Phe Asn 
    1235                 1240                 1245             


Asp Asp  Asn Ala Glu Lys Leu  Val Leu Arg Ile Arg  Ile Met Asn 
    1250                 1255                 1260             


Ser Asp  Glu Asn Lys Met Gln  Glu Glu Glu Glu Val  Val Asp Lys 
    1265                 1270                 1275             


Met Asp  Asp Asp Val Phe Leu  Arg Cys Ile Glu Ser  Asn Met Leu 
    1280                 1285                 1290             


Thr Asp  Met Thr Leu Gln Gly  Ile Glu Gln Ile Ser  Lys Val Tyr 
    1295                 1300                 1305             


Met His  Leu Pro Gln Thr Asp  Asn Lys Lys Lys Ile  Ile Ile Thr 
    1310                 1315                 1320             


Glu Asp  Gly Glu Phe Lys Ala  Leu Gln Glu Trp Ile  Leu Glu Thr 
    1325                 1330                 1335             


Asp Gly  Val Ser Leu Met Arg  Val Leu Ser Glu Lys  Asp Val Asp 
    1340                 1345                 1350             


Pro Val  Arg Thr Thr Ser Asn  Asp Ile Val Glu Ile  Phe Thr Val 
    1355                 1360                 1365             


Leu Gly  Ile Glu Ala Val Arg  Lys Ala Leu Glu Arg  Glu Leu Tyr 
    1370                 1375                 1380             


His Val  Ile Ser Phe Asp Gly  Ser Tyr Val Asn Tyr  Arg His Leu 
    1385                 1390                 1395             


Ala Leu  Leu Cys Asp Thr Met  Thr Cys Arg Gly His  Leu Met Ala 
    1400                 1405                 1410             


Ile Thr  Arg His Gly Val Asn  Arg Gln Asp Thr Gly  Pro Leu Met 
    1415                 1420                 1425             


Lys Cys  Ser Phe Glu Glu Thr  Val Asp Val Leu Met  Glu Ala Ala 
    1430                 1435                 1440             


Ala His  Gly Glu Ser Asp Pro  Met Lys Gly Val Ser  Glu Asn Ile 
    1445                 1450                 1455             


Met Leu  Gly Gln Leu Ala Pro  Ala Gly Thr Gly Cys  Phe Asp Leu 
    1460                 1465                 1470             


Leu Leu  Asp Ala Glu Lys Cys  Lys Tyr Gly Met Glu  Ile Pro Thr 
    1475                 1480                 1485             


Asn Ile  Pro Gly Leu Gly Ala  Ala Gly Pro Thr Gly  Met Phe Phe 
    1490                 1495                 1500             


Gly Ser  Ala Pro Ser Pro Met  Gly Gly Ile Ser Pro  Ala Met Thr 
    1505                 1510                 1515             


Pro Trp  Asn Gln Gly Ala Thr  Pro Ala Tyr Gly Ala  Trp Ser Pro 
    1520                 1525                 1530             


Ser Val  Gly Ser Gly Met Thr  Pro Gly Ala Ala Gly  Phe Ser Pro 
    1535                 1540                 1545             


Ser Ala  Ala Ser Asp Ala Ser  Gly Phe Ser Pro Gly  Tyr Ser Pro 
    1550                 1555                 1560             


Ala Trp  Ser Pro Thr Pro Gly  Ser Pro Gly Ser Pro  Gly Pro Ser 
    1565                 1570                 1575             


Ser Pro  Tyr Ile Pro Ser Pro  Gly Gly Ala Met Ser  Pro Ser Tyr 
    1580                 1585                 1590             


Ser Pro  Thr Ser Pro Ala Tyr  Glu Pro Arg Ser Pro  Gly Gly Tyr 
    1595                 1600                 1605             


Thr Pro  Gln Ser Pro Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser 
    1610                 1615                 1620             


Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser Pro Asn  Tyr Ser Pro 
    1625                 1630                 1635             


Thr Ser  Pro Ser Tyr Ser Pro  Thr Ser Pro Ser Tyr  Ser Pro Thr 
    1640                 1645                 1650             


Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser 
    1655                 1660                 1665             


Pro Ser  Tyr Ser Pro Thr Ser  Pro Ser Tyr Ser Pro  Thr Ser Pro 
    1670                 1675                 1680             


Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser 
    1685                 1690                 1695             


Tyr Ser  Pro Thr Ser Pro Ser  Tyr Ser Pro Thr Ser  Pro Ser Tyr 
    1700                 1705                 1710             


Ser Pro  Thr Ser Pro Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser 
    1715                 1720                 1725             


Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser Pro Ser  Tyr Ser Pro 
    1730                 1735                 1740             


Thr Ser  Pro Asn Tyr Ser Pro  Thr Ser Pro Asn Tyr  Thr Pro Thr 
    1745                 1750                 1755             


Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser 
    1760                 1765                 1770             


Pro Asn  Tyr Thr Pro Thr Ser  Pro Asn Tyr Ser Pro  Thr Ser Pro 
    1775                 1780                 1785             


Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser 
    1790                 1795                 1800             


Tyr Ser  Pro Ser Ser Pro Arg  Tyr Thr Pro Gln Ser  Pro Thr Tyr 
    1805                 1810                 1815             


Thr Pro  Ser Ser Pro Ser Tyr  Ser Pro Ser Ser Pro  Ser Tyr Ser 
    1820                 1825                 1830             


Pro Thr  Ser Pro Lys Tyr Thr  Pro Thr Ser Pro Ser  Tyr Ser Pro 
    1835                 1840                 1845             


Ser Ser  Pro Glu Tyr Thr Pro  Thr Ser Pro Lys Tyr  Ser Pro Thr 
    1850                 1855                 1860             


Ser Pro  Lys Tyr Ser Pro Thr  Ser Pro Lys Tyr Ser  Pro Thr Ser 
    1865                 1870                 1875             


Pro Thr  Tyr Ser Pro Thr Thr  Pro Lys Tyr Ser Pro  Thr Ser Pro 
    1880                 1885                 1890             


Thr Tyr  Ser Pro Thr Ser Pro  Val Tyr Thr Pro Thr  Ser Pro Lys 
    1895                 1900                 1905             


Tyr Ser  Pro Thr Ser Pro Thr  Tyr Ser Pro Thr Ser  Pro Lys Tyr 
    1910                 1915                 1920             


Ser Pro  Thr Ser Pro Thr Tyr  Ser Pro Thr Ser Pro  Lys Gly Ser 
    1925                 1930                 1935             


Thr Tyr  Ser Pro Thr Ser Pro  Gly Tyr Ser Pro Thr  Ser Pro Thr 
    1940                 1945                 1950             


Tyr Ser  Leu Thr Ser Pro Ala  Ile Ser Pro Asp Asp  Ser Asp Glu 
    1955                 1960                 1965             


Glu Asn  
    1970 


<210>  1519
<211>  272
<212>  PRT
<213>  homo sapiens

<400>  1519

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Thr Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270         


<210>  1520
<211>  669
<212>  PRT
<213>  homo sapiens

<400>  1520

Met Gln Asn Ser His Met Asp Glu Tyr Arg Asn Ser Ser Asn Gly Ser 
1               5                   10                  15      


Thr Gly Asn Ser Ser Glu Val Val Val Glu His Pro Thr Asp Phe Ser 
            20                  25                  30          


Thr Glu Ile Met Asn Val Thr Glu Met Glu Gln Ser Pro Asp Asp Ser 
        35                  40                  45              


Pro Asn Val Asn Ala Ser Thr Glu Glu Thr Glu Met Ala Ser Ala Val 
    50                  55                  60                  


Asp Leu Pro Val Thr Leu Thr Glu Thr Glu Ala Asn Phe Pro Pro Glu 
65                  70                  75                  80  


Tyr Glu Lys Phe Trp Lys Thr Val Glu Asn Asn Pro Gln Asp Phe Thr 
                85                  90                  95      


Gly Trp Val Tyr Leu Leu Gln Tyr Val Glu Gln Glu Asn His Leu Met 
            100                 105                 110         


Ala Ala Arg Lys Ala Phe Asp Arg Phe Phe Ile His Tyr Pro Tyr Cys 
        115                 120                 125             


Tyr Gly Tyr Trp Lys Lys Tyr Ala Asp Leu Glu Lys Arg His Asp Asn 
    130                 135                 140                 


Ile Lys Pro Ser Asp Glu Val Tyr Arg Arg Gly Leu Gln Ala Ile Pro 
145                 150                 155                 160 


Leu Ser Val Asp Leu Trp Ile His Tyr Ile Asn Phe Leu Lys Glu Thr 
                165                 170                 175     


Leu Asp Pro Gly Asp Pro Glu Thr Asn Asn Thr Ile Arg Gly Thr Phe 
            180                 185                 190         


Glu His Ala Val Leu Ala Ala Gly Thr Asp Phe Arg Ser Asp Arg Leu 
        195                 200                 205             


Trp Glu Met Tyr Ile Asn Trp Glu Asn Glu Gln Gly Asn Leu Arg Glu 
    210                 215                 220                 


Val Thr Ala Ile Tyr Asp Arg Ile Leu Gly Ile Pro Thr Gln Leu Tyr 
225                 230                 235                 240 


Ser His His Phe Gln Arg Phe Lys Glu His Val Gln Asn Asn Leu Pro 
                245                 250                 255     


Arg Asp Leu Leu Thr Gly Glu Gln Phe Ile Gln Leu Arg Arg Glu Leu 
            260                 265                 270         


Ala Ser Val Asn Gly His Ser Gly Asp Asp Gly Pro Pro Gly Asp Asp 
        275                 280                 285             


Leu Pro Ser Gly Ile Glu Asp Ile Thr Asp Pro Ala Lys Leu Ile Thr 
    290                 295                 300                 


Glu Ile Glu Asn Met Arg His Arg Ile Ile Glu Ile His Gln Glu Met 
305                 310                 315                 320 


Phe Asn Tyr Asn Glu His Glu Val Ser Lys Arg Trp Thr Phe Glu Glu 
                325                 330                 335     


Gly Ile Lys Arg Pro Tyr Phe His Val Lys Pro Leu Glu Lys Ala Gln 
            340                 345                 350         


Leu Lys Asn Trp Lys Glu Tyr Leu Glu Phe Glu Ile Glu Asn Gly Thr 
        355                 360                 365             


His Glu Arg Val Val Val Leu Phe Glu Arg Cys Val Ile Ser Cys Ala 
    370                 375                 380                 


Leu Tyr Glu Glu Phe Trp Ile Lys Tyr Ala Lys Tyr Met Glu Asn His 
385                 390                 395                 400 


Ser Ile Glu Gly Val Arg His Val Phe Ser Arg Ala Cys Thr Ile His 
                405                 410                 415     


Leu Pro Lys Lys Pro Met Val His Met Leu Trp Ala Ala Phe Glu Glu 
            420                 425                 430         


Gln Gln Gly Asn Ile Asn Glu Ala Arg Asn Ile Leu Lys Thr Phe Glu 
        435                 440                 445             


Glu Cys Val Leu Gly Leu Ala Met Val Arg Leu Arg Arg Val Ser Leu 
    450                 455                 460                 


Glu Arg Arg His Gly Asn Leu Glu Glu Ala Glu His Leu Leu Gln Asp 
465                 470                 475                 480 


Ala Ile Lys Asn Ala Lys Ser Asn Asn Glu Ser Ser Phe Tyr Ala Val 
                485                 490                 495     


Lys Leu Ala Arg His Leu Phe Lys Ile Gln Lys Asn Leu Pro Lys Ser 
            500                 505                 510         


Arg Lys Val Leu Leu Glu Ala Ile Glu Arg Asp Lys Glu Asn Thr Lys 
        515                 520                 525             


Leu Tyr Leu Asn Leu Leu Glu Met Glu Tyr Ser Gly Asp Leu Lys Gln 
    530                 535                 540                 


Asn Glu Glu Asn Ile Leu Asn Cys Phe Asp Lys Ala Val His Gly Ser 
545                 550                 555                 560 


Leu Pro Ile Lys Met Arg Ile Thr Phe Ser Gln Arg Lys Val Glu Phe 
                565                 570                 575     


Leu Glu Asp Phe Gly Ser Asp Val Asn Lys Leu Leu Asn Ala Tyr Asp 
            580                 585                 590         


Glu His Gln Thr Leu Leu Lys Glu Gln Asp Ser Leu Lys Arg Lys Ala 
        595                 600                 605             


Glu Asn Gly Ser Glu Glu Pro Glu Glu Lys Lys Ala His Thr Glu Asp 
    610                 615                 620                 


Thr Thr Ser Ser Ser Thr Gln Met Ile Asp Gly Asp Leu Gln Ala Asn 
625                 630                 635                 640 


Gln Ala Val Tyr Asn Tyr Ser Ala Trp Tyr Gln Tyr Asn Tyr Gln Asn 
                645                 650                 655     


Pro Trp Asn Tyr Gly Gln Tyr Tyr Pro Pro Pro Pro Thr 
            660                 665                 


<210>  1521
<211>  453
<212>  PRT
<213>  homo sapiens

<400>  1521

Met Glu Asp Tyr Leu Gln Gly Cys Arg Ala Ala Leu Gln Glu Ser Arg 
1               5                   10                  15      


Pro Leu His Val Val Leu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr 
            20                  25                  30          


Val Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala 
        35                  40                  45              


Glu Glu Val Phe Val Pro Val Leu Asn Ile Lys Arg Ser Glu Leu Pro 
    50                  55                  60                  


Leu Arg Gly Asp Ile Val Phe Phe Leu Gln Lys Val His Ile Pro Glu 
65                  70                  75                  80  


Ser Ile Leu Ile Phe Arg Asp Glu Ile Asp Leu His Ala Leu Tyr Gln 
                85                  90                  95      


Ala Gly Gln Leu Thr Leu Ile Leu Val Asp His His Ile Leu Ser Lys 
            100                 105                 110         


Ser Asp Thr Ala Leu Glu Glu Ala Val Ala Glu Val Leu Asp His Arg 
        115                 120                 125             


Pro Ile Glu Pro Lys His Cys Pro Pro Cys His Val Ser Val Glu Leu 
    130                 135                 140                 


Val Gly Ser Cys Ala Thr Leu Val Thr Glu Arg Ile Leu Gln Gly Ala 
145                 150                 155                 160 


Pro Glu Ile Leu Asp Arg Gln Thr Ala Ala Leu Leu His Gly Thr Ile 
                165                 170                 175     


Ile Leu Asp Cys Val Asn Met Asp Leu Lys Ile Gly Lys Ala Thr Pro 
            180                 185                 190         


Lys Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu 
        195                 200                 205             


Pro Lys Arg Asn Asp Ile Phe Asp Ser Leu Gln Lys Ala Lys Phe Asp 
    210                 215                 220                 


Val Ser Gly Leu Thr Thr Glu Gln Met Leu Arg Lys Asp Gln Lys Thr 
225                 230                 235                 240 


Ile Tyr Arg Gln Gly Val Lys Val Ala Ile Ser Ala Ile Tyr Met Asp 
                245                 250                 255     


Leu Glu Ala Phe Leu Gln Arg Ser Asn Leu Leu Ala Asp Leu His Ala 
            260                 265                 270         


Phe Cys Gln Ala His Ser Tyr Asp Val Leu Val Ala Met Thr Ile Phe 
        275                 280                 285             


Phe Asn Thr His Asn Glu Pro Val Arg Gln Leu Ala Ile Phe Cys Pro 
    290                 295                 300                 


His Val Ala Leu Gln Thr Thr Ile Cys Glu Val Leu Glu Arg Ser His 
305                 310                 315                 320 


Ser Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu 
                325                 330                 335     


His Ala Tyr Leu Gln Gly Asn Thr Gln Val Ser Arg Lys Lys Leu Leu 
            340                 345                 350         


Pro Leu Leu Gln Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys Ile 
        355                 360                 365             


Pro Ser Gly Gln Pro Glu Thr Ala Asp Val Ser Arg Glu Gln Val Asp 
    370                 375                 380                 


Lys Glu Leu Asp Arg Ala Ser Asn Ser Leu Ile Ser Gly Leu Ser Gln 
385                 390                 395                 400 


Asp Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val 
                405                 410                 415     


Asp Glu Cys Pro Leu Asp Gln Gly Leu Pro Lys Leu Ser Ala Glu Ala 
            420                 425                 430         


Val Phe Glu Lys Cys Ser Gln Ile Ser Leu Ser Gln Ser Thr Thr Ala 
        435                 440                 445             


Ser Leu Ser Lys Lys 
    450             


<210>  1522
<211>  504
<212>  PRT
<213>  homo sapiens

<400>  1522

Met Ala Ala Gln Ala Leu Ala Leu Leu Arg Glu Val Ala Arg Leu Glu 
1               5                   10                  15      


Ala Pro Leu Glu Glu Leu Arg Ala Leu His Ser Val Leu Gln Ala Val 
            20                  25                  30          


Pro Leu Asn Glu Leu Arg Gln Gln Ala Ala Glu Leu Arg Leu Gly Pro 
        35                  40                  45              


Leu Phe Ser Leu Leu Asn Glu Asn His Arg Glu Lys Thr Thr Leu Cys 
    50                  55                  60                  


Val Ser Ile Leu Glu Arg Leu Leu Gln Ala Met Glu Pro Val His Val 
65                  70                  75                  80  


Ala Arg Asn Leu Arg Val Asp Leu Gln Arg Gly Leu Ile His Pro Asp 
                85                  90                  95      


Asp Ser Val Lys Ile Leu Thr Leu Ser Gln Ile Gly Arg Ile Val Glu 
            100                 105                 110         


Asn Ser Asp Ala Val Thr Glu Ile Leu Asn Asn Ala Glu Leu Leu Lys 
        115                 120                 125             


Gln Ile Val Tyr Cys Ile Gly Gly Glu Asn Leu Ser Val Ala Lys Ala 
    130                 135                 140                 


Ala Ile Lys Ser Leu Ser Arg Ile Ser Leu Thr Gln Ala Gly Leu Glu 
145                 150                 155                 160 


Ala Leu Phe Glu Ser Asn Leu Leu Asp Asp Leu Lys Ser Val Met Lys 
                165                 170                 175     


Thr Asn Asp Ile Val Arg Tyr Arg Val Tyr Glu Leu Ile Ile Glu Ile 
            180                 185                 190         


Ser Ser Val Ser Pro Glu Ser Leu Asn Tyr Cys Thr Thr Ser Gly Leu 
        195                 200                 205             


Val Thr Gln Leu Leu Arg Glu Leu Thr Gly Glu Asp Val Leu Val Arg 
    210                 215                 220                 


Ala Thr Cys Ile Glu Met Val Thr Ser Leu Ala Tyr Thr His His Gly 
225                 230                 235                 240 


Arg Gln Tyr Leu Ala Gln Glu Gly Val Ile Asp Gln Ile Ser Asn Ile 
                245                 250                 255     


Ile Val Gly Ala Asp Ser Asp Pro Phe Ser Ser Phe Tyr Leu Pro Gly 
            260                 265                 270         


Phe Val Lys Phe Phe Gly Asn Leu Ala Val Met Asp Ser Pro Gln Gln 
        275                 280                 285             


Ile Cys Glu Arg Tyr Pro Ile Phe Val Glu Lys Val Phe Glu Met Ile 
    290                 295                 300                 


Glu Ser Gln Asp Pro Thr Met Ile Gly Val Ala Val Asp Thr Val Gly 
305                 310                 315                 320 


Ile Leu Gly Ser Asn Val Glu Gly Lys Gln Val Leu Gln Lys Thr Gly 
                325                 330                 335     


Thr Arg Phe Glu Arg Leu Leu Met Arg Ile Gly His Gln Ser Lys Asn 
            340                 345                 350         


Ala Pro Val Glu Leu Lys Ile Arg Cys Leu Asp Ala Ile Ser Ser Leu 
        355                 360                 365             


Leu Tyr Leu Pro Pro Glu Gln Gln Thr Asp Asp Leu Leu Arg Met Thr 
    370                 375                 380                 


Glu Ser Trp Phe Ser Ser Leu Ser Arg Asp Pro Leu Glu Leu Phe Arg 
385                 390                 395                 400 


Gly Ile Ser Ser Gln Pro Phe Pro Glu Leu His Cys Ala Ala Leu Lys 
                405                 410                 415     


Val Phe Thr Ala Ile Ala Asn Gln Pro Trp Ala Gln Lys Leu Met Phe 
            420                 425                 430         


Asn Ser Pro Gly Phe Val Glu Tyr Val Val Asp Arg Ser Val Glu His 
        435                 440                 445             


Asp Lys Ala Ser Lys Asp Ala Lys Tyr Glu Leu Val Lys Ala Leu Ala 
    450                 455                 460                 


Asn Ser Lys Thr Ile Ala Glu Ile Phe Gly Asn Pro Asn Tyr Leu Arg 
465                 470                 475                 480 


Leu Arg Thr Tyr Leu Ser Glu Gly Pro Tyr Tyr Val Lys Pro Val Ser 
                485                 490                 495     


Thr Thr Ala Val Glu Gly Ala Glu 
            500                 


<210>  1523
<211>  599
<212>  PRT
<213>  homo sapiens

<400>  1523

Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 
            20                  25                  30          


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 
        35                  40                  45              


Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
    50                  55                  60                  


Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 
65                  70                  75                  80  


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 
                85                  90                  95      


Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 
            100                 105                 110         


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
        115                 120                 125             


Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
    130                 135                 140                 


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
145                 150                 155                 160 


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 
                165                 170                 175     


Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 
            180                 185                 190         


Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
        195                 200                 205             


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
    210                 215                 220                 


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 
225                 230                 235                 240 


Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
                245                 250                 255     


Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 
            260                 265                 270         


His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 
        275                 280                 285             


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 
    290                 295                 300                 


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 
305                 310                 315                 320 


Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
                325                 330                 335     


Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 
            340                 345                 350         


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 
        355                 360                 365             


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 
    370                 375                 380                 


His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu 
385                 390                 395                 400 


Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 
                405                 410                 415     


Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg 
            420                 425                 430         


Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val 
        435                 440                 445             


Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu 
    450                 455                 460                 


Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu 
465                 470                 475                 480 


Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 
                485                 490                 495     


Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His 
            500                 505                 510         


Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe 
        515                 520                 525             


Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 
    530                 535                 540                 


Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr 
545                 550                 555                 560 


Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 
                565                 570                 575     


Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val 
            580                 585                 590         


Glu Arg Pro Ser Thr Glu Leu 
        595                 


<210>  1524
<211>  501
<212>  PRT
<213>  homo sapiens

<400>  1524

Met Asn Arg Ser Arg Gln Val Thr Cys Val Ala Trp Val Arg Cys Gly 
1               5                   10                  15      


Val Ala Lys Glu Thr Pro Asp Lys Val Glu Leu Ser Lys Glu Glu Val 
            20                  25                  30          


Lys Arg Leu Ile Ala Glu Ala Lys Glu Lys Leu Gln Glu Glu Gly Gly 
        35                  40                  45              


Gly Ser Asp Glu Glu Glu Thr Gly Ser Pro Ser Glu Asp Gly Met Gln 
    50                  55                  60                  


Ser Ala Arg Thr Gln Ala Arg Pro Arg Glu Pro Leu Glu Asp Gly Asp 
65                  70                  75                  80  


Pro Glu Asp Asp Arg Thr Leu Asp Asp Asp Glu Leu Ala Glu Tyr Asp 
                85                  90                  95      


Leu Asp Lys Tyr Asp Glu Glu Gly Asp Pro Asp Ala Glu Thr Leu Gly 
            100                 105                 110         


Glu Ser Leu Leu Gly Leu Thr Val Tyr Gly Ser Asn Asp Gln Asp Pro 
        115                 120                 125             


Tyr Val Thr Leu Lys Asp Thr Glu Gln Tyr Glu Arg Glu Asp Phe Leu 
    130                 135                 140                 


Ile Lys Pro Ser Asp Asn Leu Ile Val Cys Gly Arg Ala Glu Gln Asp 
145                 150                 155                 160 


Gln Cys Asn Leu Glu Val His Val Tyr Asn Gln Glu Glu Asp Ser Phe 
                165                 170                 175     


Tyr Val His His Asp Ile Leu Leu Ser Ala Tyr Pro Leu Ser Val Glu 
            180                 185                 190         


Trp Leu Asn Phe Asp Pro Ser Pro Asp Asp Ser Thr Gly Asn Tyr Ile 
        195                 200                 205             


Ala Val Gly Asn Met Thr Pro Val Ile Glu Val Trp Asp Leu Asp Ile 
    210                 215                 220                 


Val Asp Ser Leu Glu Pro Val Phe Thr Leu Gly Ser Lys Leu Ser Lys 
225                 230                 235                 240 


Lys Lys Lys Lys Lys Gly Lys Lys Ser Ser Ser Ala Glu Gly His Thr 
                245                 250                 255     


Asp Ala Val Leu Asp Leu Ser Trp Asn Lys Leu Ile Arg Asn Val Leu 
            260                 265                 270         


Ala Ser Ala Ser Ala Asp Asn Thr Val Ile Leu Trp Asp Met Ser Leu 
        275                 280                 285             


Gly Lys Pro Ala Ala Ser Leu Ala Val His Thr Asp Lys Val Gln Thr 
    290                 295                 300                 


Leu Gln Phe His Pro Phe Glu Ala Gln Thr Leu Ile Ser Gly Ser Tyr 
305                 310                 315                 320 


Asp Lys Ser Val Ala Leu Tyr Asp Cys Arg Ser Pro Asp Glu Ser His 
                325                 330                 335     


Arg Met Trp Arg Phe Ser Gly Gln Ile Glu Arg Val Thr Trp Asn His 
            340                 345                 350         


Phe Ser Pro Cys His Phe Leu Ala Ser Thr Asp Asp Gly Phe Val Tyr 
        355                 360                 365             


Asn Leu Asp Ala Arg Ser Asp Lys Pro Ile Phe Thr Leu Asn Ala His 
    370                 375                 380                 


Asn Asp Glu Ile Ser Gly Leu Asp Leu Ser Ser Gln Ile Lys Gly Cys 
385                 390                 395                 400 


Leu Val Thr Ala Ser Ala Asp Lys Tyr Val Lys Ile Trp Asp Ile Leu 
                405                 410                 415     


Gly Asp Arg Pro Ser Leu Val His Ser Arg Asp Met Lys Met Gly Val 
            420                 425                 430         


Leu Phe Cys Ser Ser Cys Cys Pro Asp Leu Pro Phe Ile Tyr Ala Phe 
        435                 440                 445             


Gly Gly Gln Lys Glu Gly Leu Arg Val Trp Asp Ile Ser Thr Val Ser 
    450                 455                 460                 


Ser Val Asn Glu Ala Phe Gly Arg Arg Glu Arg Leu Val Leu Gly Ser 
465                 470                 475                 480 


Ala Arg Asn Ser Ser Ile Ser Gly Pro Phe Gly Ser Arg Ser Ser Asp 
                485                 490                 495     


Thr Pro Met Glu Ser 
            500     


<210>  1525
<211>  512
<212>  PRT
<213>  homo sapiens

<400>  1525

Met Met Leu Ser Glu Gln Ala Gln Lys Trp Phe Pro Thr His Val Gln 
1               5                   10                  15      


Val Thr Val Leu Gln Ala Lys Asp Leu Lys Pro Lys Gly Lys Ser Gly 
            20                  25                  30          


Thr Asn Asp Thr Tyr Thr Ile Ile Gln Leu Gly Lys Glu Lys Tyr Ser 
        35                  40                  45              


Thr Ser Val Ala Glu Lys Thr Leu Glu Pro Val Trp Lys Glu Glu Ala 
    50                  55                  60                  


Ser Phe Glu Leu Pro Gly Leu Leu Ile Gln Gly Ser Pro Glu Lys Tyr 
65                  70                  75                  80  


Ile Leu Phe Leu Ile Val Met His Arg Ser Leu Val Gly Leu Asp Lys 
                85                  90                  95      


Phe Leu Gly Gln Val Ala Ile Asn Leu Asn Asp Ile Phe Glu Asp Lys 
            100                 105                 110         


Gln Arg Arg Lys Thr Glu Trp Phe Arg Leu Glu Ser Lys Gln Gly Lys 
        115                 120                 125             


Arg Ile Lys Asn Arg Gly Glu Ile Lys Val Asn Ile Gln Phe Met Arg 
    130                 135                 140                 


Asn Asn Met Thr Ala Ser Met Phe Asp Leu Ser Met Lys Asp Lys Thr 
145                 150                 155                 160 


Arg Ser Pro Phe Ala Lys Leu Lys Asp Lys Met Lys Gly Arg Lys Asn 
                165                 170                 175     


Asp Gly Thr Phe Ser Asp Thr Ser Ser Ala Ile Ile Pro Ser Thr His 
            180                 185                 190         


Met Pro Asp Ala Asn Ser Glu Phe Ser Ser Gly Glu Ile Gln Met Lys 
        195                 200                 205             


Ser Lys Pro Lys Lys Pro Phe Leu Leu Gly Pro Gln Arg Leu Ser Ser 
    210                 215                 220                 


Ala His Ser Met Ser Asp Leu Ser Gly Ser His Met Ser Ser Glu Lys 
225                 230                 235                 240 


Leu Lys Ala Gly Thr Ile Gly Gln Thr His Leu Leu Gly His Gln Leu 
                245                 250                 255     


Asp Ser Phe Gly Thr Val Pro Glu Ser Gly Ser Leu Lys Ser Pro His 
            260                 265                 270         


Arg Arg Thr Leu Ser Phe Asp Thr Ser Lys Met Asn Gln Pro Asp Ser 
        275                 280                 285             


Ile Val Asp Glu Gly Glu Leu Cys Phe Gly Arg Gln Asn Asp Pro Phe 
    290                 295                 300                 


Thr Asn Val Thr Ala Ser Leu Pro Gln Lys Phe Ala Thr Leu Pro Arg 
305                 310                 315                 320 


Lys Lys Asn Pro Phe Glu Glu Ser Ser Glu Thr Trp Asp Ser Ser Met 
                325                 330                 335     


Asn Leu Phe Ser Lys Pro Ile Glu Ile Arg Lys Glu Asn Lys Arg Glu 
            340                 345                 350         


Lys Arg Glu Lys Val Ser Leu Phe Glu Arg Val Thr Gly Lys Lys Asp 
        355                 360                 365             


Ser Arg Arg Ser Asp Lys Leu Asn Asn Gly Gly Ser Asp Ser Pro Cys 
    370                 375                 380                 


Asp Leu Lys Ser Pro Asn Ala Phe Ser Glu Asn Arg Gln Asp Tyr Phe 
385                 390                 395                 400 


Asp Tyr Glu Ser Thr Asn Pro Phe Thr Ala Lys Phe Arg Ala Ser Asn 
                405                 410                 415     


Ile Met Pro Ser Ser Ser Phe His Met Ser Pro Thr Ser Asn Glu Asp 
            420                 425                 430         


Leu Arg Lys Ile Pro Asp Ser Asn Pro Phe Asp Ala Thr Ala Gly Tyr 
        435                 440                 445             


Arg Ser Leu Thr Tyr Glu Glu Val Leu Gln Glu Leu Val Lys His Lys 
    450                 455                 460                 


Glu Leu Leu Arg Arg Lys Asp Thr His Ile Arg Glu Leu Glu Asp Tyr 
465                 470                 475                 480 


Ile Asp Asn Leu Leu Val Arg Val Met Glu Glu Thr Pro Ser Ile Leu 
                485                 490                 495     


Arg Val Pro Tyr Glu Pro Ser Arg Lys Ala Gly Lys Phe Ser Asn Ser 
            500                 505                 510         


<210>  1526
<211>  815
<212>  PRT
<213>  homo sapiens

<400>  1526

Met Glu Val Arg Ala Ser Leu Gln Lys Val Ser Gly Ser Ser Asp Ser 
1               5                   10                  15      


Val Ala Thr Met Asn Ser Glu Glu Phe Val Leu Val Pro Gln Tyr Ala 
            20                  25                  30          


Asp Asp Asn Ser Thr Lys His Glu Glu Lys Pro Gln Leu Lys Ile Val 
        35                  40                  45              


Ser Asn Gly Asp Glu Gln Leu Glu Lys Ala Met Glu Glu Ile Leu Arg 
    50                  55                  60                  


Asp Ser Glu Lys Arg Pro Ser Ser Leu Leu Val Asp Cys Gln Ser Ser 
65                  70                  75                  80  


Ser Glu Ile Ser Asp His Ser Phe Gly Asp Ile Pro Ala Ser Gln Thr 
                85                  90                  95      


Asn Lys Pro Ser Leu Gln Leu Ile Leu Asp Pro Ser Asn Thr Glu Ile 
            100                 105                 110         


Ser Thr Pro Arg Pro Ser Ser Pro Gly Gly Leu Pro Glu Glu Asp Ser 
        115                 120                 125             


Val Leu Phe Asn Lys Leu Thr Tyr Leu Gly Cys Met Lys Val Ser Ser 
    130                 135                 140                 


Pro Arg Asn Glu Val Glu Ala Leu Arg Ala Met Ala Thr Met Lys Ser 
145                 150                 155                 160 


Ser Ser Gln Tyr Pro Phe Pro Val Thr Leu Tyr Val Pro Asn Val Pro 
                165                 170                 175     


Glu Gly Ser Val Arg Ile Ile Asp Gln Ser Ser Asn Val Glu Ile Ala 
            180                 185                 190         


Ser Phe Pro Ile Tyr Lys Val Leu Phe Cys Ala Arg Gly His Asp Gly 
        195                 200                 205             


Thr Thr Glu Ser Asn Cys Phe Ala Phe Thr Glu Ser Ser His Gly Ser 
    210                 215                 220                 


Glu Glu Phe Gln Ile His Val Phe Ser Cys Glu Ile Lys Glu Ala Val 
225                 230                 235                 240 


Ser Arg Ile Leu Tyr Ser Phe Cys Thr Ala Phe Lys Arg Ser Ser Arg 
                245                 250                 255     


Gln Val Ser Asp Val Lys Asp Ser Val Ile Pro Thr Pro Asp Ser Asp 
            260                 265                 270         


Val Phe Thr Phe Ser Val Ser Leu Glu Val Lys Glu Asp Asp Gly Lys 
        275                 280                 285             


Gly Asn Phe Ser Pro Val Pro Lys Asp Arg Asp Lys Phe Tyr Phe Lys 
    290                 295                 300                 


Leu Lys Gln Gly Ile Glu Lys Lys Val Val Ile Thr Val Gln Gln Leu 
305                 310                 315                 320 


Ser Asn Lys Glu Leu Ala Ile Glu Arg Cys Phe Gly Met Leu Leu Ser 
                325                 330                 335     


Pro Gly Arg Asn Val Lys Asn Ser Asp Met His Leu Leu Asp Met Glu 
            340                 345                 350         


Ser Met Gly Lys Ser Tyr Asp Gly Arg Ala Tyr Val Ile Thr Gly Met 
        355                 360                 365             


Trp Asn Pro Asn Ala Pro Val Phe Leu Ala Leu Asn Glu Glu Thr Pro 
    370                 375                 380                 


Lys Asp Lys Gln Val Tyr Met Thr Val Ala Val Asp Met Val Val Thr 
385                 390                 395                 400 


Glu Val Val Glu Pro Val Arg Phe Leu Leu Glu Thr Val Val Arg Val 
                405                 410                 415     


Tyr Pro Ala Asn Glu Arg Phe Trp Tyr Phe Ser Arg Lys Thr Phe Thr 
            420                 425                 430         


Glu Thr Phe Phe Met Arg Leu Lys Gln Ser Glu Gly Lys Gly His Thr 
        435                 440                 445             


Asn Ala Gly Asp Ala Ile Tyr Glu Val Val Ser Leu Gln Arg Glu Ser 
    450                 455                 460                 


Asp Lys Glu Glu Pro Val Thr Pro Thr Ser Gly Gly Gly Pro Met Ser 
465                 470                 475                 480 


Pro Gln Asp Asp Glu Ala Glu Glu Glu Ser Asp Asn Glu Leu Ser Ser 
                485                 490                 495     


Gly Thr Gly Asp Val Ser Lys Asp Cys Pro Glu Lys Ile Leu Tyr Ser 
            500                 505                 510         


Trp Gly Glu Leu Leu Gly Lys Trp His Ser Asn Leu Gly Ala Arg Pro 
        515                 520                 525             


Lys Gly Leu Ser Thr Leu Val Lys Ser Gly Val Pro Glu Ala Leu Arg 
    530                 535                 540                 


Ala Glu Val Trp Gln Leu Leu Ala Gly Cys His Asp Asn Gln Ala Met 
545                 550                 555                 560 


Leu Asp Arg Tyr Arg Ile Leu Ile Thr Lys Asp Ser Ala Gln Glu Ser 
                565                 570                 575     


Val Ile Thr Arg Asp Ile His Arg Thr Phe Pro Ala His Asp Tyr Phe 
            580                 585                 590         


Lys Asp Thr Gly Gly Asp Gly Gln Glu Ser Leu Tyr Lys Ile Cys Lys 
        595                 600                 605             


Ala Tyr Ser Val Tyr Asp Glu Asp Ile Gly Tyr Cys Gln Gly Gln Ser 
    610                 615                 620                 


Phe Leu Ala Ala Val Leu Leu Leu His Met Pro Glu Glu Gln Ala Phe 
625                 630                 635                 640 


Cys Val Leu Val Lys Ile Met Tyr Asp Tyr Gly Leu Arg Asp Leu Tyr 
                645                 650                 655     


Arg Asn Asn Phe Glu Asp Leu His Cys Lys Phe Tyr Gln Leu Glu Arg 
            660                 665                 670         


Leu Met Gln Glu Gln Leu Pro Asp Leu His Ser His Phe Ser Asp Leu 
        675                 680                 685             


Asn Leu Glu Ala His Met Tyr Ala Ser Gln Trp Phe Leu Thr Leu Phe 
    690                 695                 700                 


Thr Ala Lys Phe Pro Leu Cys Met Val Phe His Ile Ile Asp Leu Leu 
705                 710                 715                 720 


Leu Cys Glu Gly Leu Asn Ile Ile Phe His Val Ala Leu Ala Leu Leu 
                725                 730                 735     


Lys Thr Ser Lys Glu Asp Leu Leu Gln Ala Asp Phe Glu Gly Ala Leu 
            740                 745                 750         


Lys Phe Phe Arg Val Gln Leu Pro Lys Arg Tyr Arg Ala Glu Glu Asn 
        755                 760                 765             


Ala Arg Arg Leu Met Glu Gln Ala Cys Asn Ile Lys Val Pro Thr Lys 
    770                 775                 780                 


Lys Leu Lys Lys Tyr Glu Lys Glu Tyr Gln Thr Met Arg Glu Ser Gln 
785                 790                 795                 800 


Leu Gln Gln Glu Asp Pro Met Asp Arg Tyr Lys Phe Val Tyr Leu 
                805                 810                 815 


<210>  1527
<211>  1312
<212>  PRT
<213>  homo sapiens

<400>  1527

Met Ser Arg Ile Glu Lys Met Ser Ile Leu Gly Val Arg Ser Phe Gly 
1               5                   10                  15      


Ile Glu Asp Lys Asp Lys Gln Ile Ile Thr Phe Phe Ser Pro Leu Thr 
            20                  25                  30          


Ile Leu Val Gly Pro Asn Gly Ala Gly Lys Thr Thr Ile Ile Glu Cys 
        35                  40                  45              


Leu Lys Tyr Ile Cys Thr Gly Asp Phe Pro Pro Gly Thr Lys Gly Asn 
    50                  55                  60                  


Thr Phe Val His Asp Pro Lys Val Ala Gln Glu Thr Asp Val Arg Ala 
65                  70                  75                  80  


Gln Ile Arg Leu Gln Phe Arg Asp Val Asn Gly Glu Leu Ile Ala Val 
                85                  90                  95      


Gln Arg Ser Met Val Cys Thr Gln Lys Ser Lys Lys Thr Glu Phe Lys 
            100                 105                 110         


Thr Leu Glu Gly Val Ile Thr Arg Thr Lys His Gly Glu Lys Val Ser 
        115                 120                 125             


Leu Ser Ser Lys Cys Ala Glu Ile Asp Arg Glu Met Ile Ser Ser Leu 
    130                 135                 140                 


Gly Val Ser Lys Ala Val Leu Asn Asn Val Ile Phe Cys His Gln Glu 
145                 150                 155                 160 


Asp Ser Asn Trp Pro Leu Ser Glu Gly Lys Ala Leu Lys Gln Lys Phe 
                165                 170                 175     


Asp Glu Ile Phe Ser Ala Thr Arg Tyr Ile Lys Ala Leu Glu Thr Leu 
            180                 185                 190         


Arg Gln Val Arg Gln Thr Gln Gly Gln Lys Val Lys Glu Tyr Gln Met 
        195                 200                 205             


Glu Leu Lys Tyr Leu Lys Gln Tyr Lys Glu Lys Ala Cys Glu Ile Arg 
    210                 215                 220                 


Asp Gln Ile Thr Ser Lys Glu Ala Gln Leu Thr Ser Ser Lys Glu Ile 
225                 230                 235                 240 


Val Lys Ser Tyr Glu Asn Glu Leu Asp Pro Leu Lys Asn Arg Leu Lys 
                245                 250                 255     


Glu Ile Glu His Asn Leu Ser Lys Ile Met Lys Leu Asp Asn Glu Ile 
            260                 265                 270         


Lys Ala Leu Asp Ser Arg Lys Lys Gln Met Glu Lys Asp Asn Ser Glu 
        275                 280                 285             


Leu Glu Glu Lys Met Glu Lys Val Phe Gln Gly Thr Asp Glu Gln Leu 
    290                 295                 300                 


Asn Asp Leu Tyr His Asn His Gln Arg Thr Val Arg Glu Lys Glu Arg 
305                 310                 315                 320 


Lys Leu Val Asp Cys His Arg Glu Leu Glu Lys Leu Asn Lys Glu Ser 
                325                 330                 335     


Arg Leu Leu Asn Gln Glu Lys Ser Glu Leu Leu Val Glu Gln Gly Arg 
            340                 345                 350         


Leu Gln Leu Gln Ala Asp Arg His Gln Glu His Ile Arg Ala Arg Asp 
        355                 360                 365             


Ser Leu Ile Gln Ser Leu Ala Thr Gln Leu Glu Leu Asp Gly Phe Glu 
    370                 375                 380                 


Arg Gly Pro Phe Ser Glu Arg Gln Ile Lys Asn Phe His Lys Leu Val 
385                 390                 395                 400 


Arg Glu Arg Gln Glu Gly Glu Ala Lys Thr Ala Asn Gln Leu Met Asn 
                405                 410                 415     


Asp Phe Ala Glu Lys Glu Thr Leu Lys Gln Lys Gln Ile Asp Glu Ile 
            420                 425                 430         


Arg Asp Lys Lys Thr Gly Leu Gly Arg Ile Ile Glu Leu Lys Ser Glu 
        435                 440                 445             


Ile Leu Ser Lys Lys Gln Asn Glu Leu Lys Asn Val Lys Tyr Glu Leu 
    450                 455                 460                 


Gln Gln Leu Glu Gly Ser Ser Asp Arg Ile Leu Glu Leu Asp Gln Glu 
465                 470                 475                 480 


Leu Ile Lys Ala Glu Arg Glu Leu Ser Lys Ala Glu Lys Asn Ser Asn 
                485                 490                 495     


Val Glu Thr Leu Lys Met Glu Val Ile Ser Leu Gln Asn Glu Lys Ala 
            500                 505                 510         


Asp Leu Asp Arg Thr Leu Arg Lys Leu Asp Gln Glu Met Glu Gln Leu 
        515                 520                 525             


Asn His His Thr Thr Thr Arg Thr Gln Met Glu Met Leu Thr Lys Asp 
    530                 535                 540                 


Lys Ala Asp Lys Asp Glu Gln Ile Arg Lys Ile Lys Ser Arg His Ser 
545                 550                 555                 560 


Asp Glu Leu Thr Ser Leu Leu Gly Tyr Phe Pro Asn Lys Lys Gln Leu 
                565                 570                 575     


Glu Asp Trp Leu His Ser Lys Ser Lys Glu Ile Asn Gln Thr Arg Asp 
            580                 585                 590         


Arg Leu Ala Lys Leu Asn Lys Glu Leu Ala Ser Ser Glu Gln Asn Lys 
        595                 600                 605             


Asn His Ile Asn Asn Glu Leu Lys Arg Lys Glu Glu Gln Leu Ser Ser 
    610                 615                 620                 


Tyr Glu Asp Lys Leu Phe Asp Val Cys Gly Ser Gln Asp Phe Glu Ser 
625                 630                 635                 640 


Asp Leu Asp Arg Leu Lys Glu Glu Ile Glu Lys Ser Ser Lys Gln Arg 
                645                 650                 655     


Ala Met Leu Ala Gly Ala Thr Ala Val Tyr Ser Gln Phe Ile Thr Gln 
            660                 665                 670         


Leu Thr Asp Glu Asn Gln Ser Cys Cys Pro Val Cys Gln Arg Val Phe 
        675                 680                 685             


Gln Thr Glu Ala Glu Leu Gln Glu Val Ile Ser Asp Leu Gln Ser Lys 
    690                 695                 700                 


Leu Arg Leu Ala Pro Asp Lys Leu Lys Ser Thr Glu Ser Glu Leu Lys 
705                 710                 715                 720 


Lys Lys Glu Lys Arg Arg Asp Glu Met Leu Gly Leu Val Pro Met Arg 
                725                 730                 735     


Gln Ser Ile Ile Asp Leu Lys Glu Lys Glu Ile Pro Glu Leu Arg Asn 
            740                 745                 750         


Lys Leu Gln Asn Val Asn Arg Asp Ile Gln Arg Leu Lys Asn Asp Ile 
        755                 760                 765             


Glu Glu Gln Glu Thr Leu Leu Gly Thr Ile Met Pro Glu Glu Glu Ser 
    770                 775                 780                 


Ala Lys Val Cys Leu Thr Asp Val Thr Ile Met Glu Arg Phe Gln Met 
785                 790                 795                 800 


Glu Leu Lys Asp Val Glu Arg Lys Ile Ala Gln Gln Ala Ala Lys Leu 
                805                 810                 815     


Gln Gly Ile Asp Leu Asp Arg Thr Val Gln Gln Val Asn Gln Glu Lys 
            820                 825                 830         


Gln Glu Lys Gln His Lys Leu Asp Thr Val Ser Ser Lys Ile Glu Leu 
        835                 840                 845             


Asn Arg Lys Leu Ile Gln Asp Gln Gln Glu Gln Ile Gln His Leu Lys 
    850                 855                 860                 


Ser Thr Thr Asn Glu Leu Lys Ser Glu Lys Leu Gln Ile Ser Thr Asn 
865                 870                 875                 880 


Leu Gln Arg Arg Gln Gln Leu Glu Glu Gln Thr Val Glu Leu Ser Thr 
                885                 890                 895     


Glu Val Gln Ser Leu Tyr Arg Glu Ile Lys Asp Ala Lys Glu Gln Val 
            900                 905                 910         


Ser Pro Leu Glu Thr Thr Leu Glu Lys Phe Gln Gln Glu Lys Glu Glu 
        915                 920                 925             


Leu Ile Asn Lys Lys Asn Thr Ser Asn Lys Ile Ala Gln Asp Lys Leu 
    930                 935                 940                 


Asn Asp Ile Lys Glu Lys Val Lys Asn Ile His Gly Tyr Met Lys Asp 
945                 950                 955                 960 


Ile Glu Asn Tyr Ile Gln Asp Gly Lys Asp Asp Tyr Lys Lys Gln Lys 
                965                 970                 975     


Glu Thr Glu Leu Asn Lys Val Ile Ala Gln Leu Ser Glu Cys Glu Lys 
            980                 985                 990         


His Lys Glu Lys Ile Asn Glu Asp  Met Arg Leu Met Arg  Gln Asp Ile 
        995                 1000                 1005             


Asp Thr  Gln Lys Ile Gln Glu  Arg Trp Leu Gln Asp  Asn Leu Thr 
    1010                 1015                 1020             


Leu Arg  Lys Arg Asn Glu Glu  Leu Lys Glu Val Glu  Glu Glu Arg 
    1025                 1030                 1035             


Lys Gln  His Leu Lys Glu Met  Gly Gln Met Gln Val  Leu Gln Met 
    1040                 1045                 1050             


Lys Ser  Glu His Gln Lys Leu  Glu Glu Asn Ile Asp  Asn Ile Lys 
    1055                 1060                 1065             


Arg Asn  His Asn Leu Ala Leu  Gly Arg Gln Lys Gly  Tyr Glu Glu 
    1070                 1075                 1080             


Glu Ile  Ile His Phe Lys Lys  Glu Leu Arg Glu Pro  Gln Phe Arg 
    1085                 1090                 1095             


Asp Ala  Glu Glu Lys Tyr Arg  Glu Met Met Ile Val  Met Arg Thr 
    1100                 1105                 1110             


Thr Glu  Leu Val Asn Lys Asp  Leu Asp Ile Tyr Tyr  Lys Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ala Ile Met Lys Phe  His Ser Met Lys Met  Glu Glu Ile 
    1130                 1135                 1140             


Asn Lys  Ile Ile Arg Asp Leu  Trp Arg Ser Thr Tyr  Arg Gly Gln 
    1145                 1150                 1155             


Asp Ile  Glu Tyr Ile Glu Ile  Arg Ser Asp Ala Asp  Glu Asn Val 
    1160                 1165                 1170             


Ser Ala  Ser Asp Lys Arg Arg  Asn Tyr Asn Tyr Arg  Val Val Met 
    1175                 1180                 1185             


Leu Lys  Gly Asp Thr Ala Leu  Asp Met Arg Gly Arg  Cys Ser Ala 
    1190                 1195                 1200             


Gly Gln  Lys Val Leu Ala Ser  Leu Ile Ile Arg Leu  Ala Leu Ala 
    1205                 1210                 1215             


Glu Thr  Phe Cys Leu Asn Cys  Gly Ile Ile Ala Leu  Asp Glu Pro 
    1220                 1225                 1230             


Thr Thr  Asn Leu Asp Arg Glu  Asn Ile Glu Ser Leu  Ala His Ala 
    1235                 1240                 1245             


Leu Val  Glu Ile Ile Lys Ser  Arg Ser Gln Gln Arg  Asn Phe Gln 
    1250                 1255                 1260             


Leu Leu  Val Ile Thr His Asp  Glu Asp Phe Val Glu  Leu Leu Gly 
    1265                 1270                 1275             


Arg Ser  Glu Tyr Val Glu Lys  Phe Tyr Arg Ile Lys  Lys Asn Ile 
    1280                 1285                 1290             


Asp Gln  Cys Ser Glu Ile Val  Lys Cys Ser Val Ser  Ser Leu Gly 
    1295                 1300                 1305             


Phe Asn  Val His 
    1310         


<210>  1528
<211>  980
<212>  PRT
<213>  homo sapiens

<400>  1528

Met Val Ser Lys Met Ile Ile Glu Asn Phe Glu Ala Leu Lys Ser Trp 
1               5                   10                  15      


Leu Ser Lys Thr Leu Glu Pro Ile Cys Asp Ala Asp Pro Ser Ala Leu 
            20                  25                  30          


Ala Lys Tyr Val Leu Ala Leu Val Lys Lys Asp Lys Ser Glu Lys Glu 
        35                  40                  45              


Leu Lys Ala Leu Cys Ile Asp Gln Leu Asp Val Phe Leu Gln Lys Glu 
    50                  55                  60                  


Thr Gln Ile Phe Val Glu Lys Leu Phe Asp Ala Val Asn Thr Lys Ser 
65                  70                  75                  80  


Tyr Leu Pro Pro Pro Glu Gln Pro Ser Ser Gly Ser Leu Lys Val Glu 
                85                  90                  95      


Phe Phe Pro His Gln Glu Lys Asp Ile Lys Lys Glu Glu Ile Thr Lys 
            100                 105                 110         


Glu Glu Glu Arg Glu Lys Lys Phe Ser Arg Arg Leu Asn His Ser Pro 
        115                 120                 125             


Pro Gln Ser Ser Ser Arg Tyr Arg Glu Asn Arg Ser Arg Asp Glu Arg 
    130                 135                 140                 


Lys Lys Asp Asp Arg Ser Arg Lys Arg Asp Tyr Asp Arg Asn Pro Pro 
145                 150                 155                 160 


Arg Arg Asp Ser Tyr Arg Asp Arg Tyr Asn Arg Arg Arg Gly Arg Ser 
                165                 170                 175     


Arg Ser Tyr Ser Arg Ser Arg Ser Arg Ser Trp Ser Lys Glu Arg Leu 
            180                 185                 190         


Arg Glu Arg Asp Arg Asp Arg Ser Arg Thr Arg Ser Arg Ser Arg Thr 
        195                 200                 205             


Arg Ser Arg Glu Arg Asp Leu Val Lys Pro Lys Tyr Asp Leu Asp Arg 
    210                 215                 220                 


Thr Asp Pro Leu Glu Asn Asn Tyr Thr Pro Val Ser Ser Val Pro Ser 
225                 230                 235                 240 


Ile Ser Ser Gly His Tyr Pro Val Pro Thr Leu Ser Ser Thr Ile Thr 
                245                 250                 255     


Val Ile Ala Pro Thr His His Gly Asn Asn Thr Thr Glu Ser Trp Ser 
            260                 265                 270         


Glu Phe His Glu Asp Gln Val Asp His Asn Ser Tyr Val Arg Pro Pro 
        275                 280                 285             


Met Pro Lys Lys Arg Cys Arg Asp Tyr Asp Glu Lys Gly Phe Cys Met 
    290                 295                 300                 


Arg Gly Asp Met Cys Pro Phe Asp His Gly Ser Asp Pro Val Val Val 
305                 310                 315                 320 


Glu Asp Val Asn Leu Pro Gly Met Leu Pro Phe Pro Ala Gln Pro Pro 
                325                 330                 335     


Val Val Glu Gly Pro Pro Pro Pro Gly Leu Pro Pro Pro Pro Pro Ile 
            340                 345                 350         


Leu Thr Pro Pro Pro Val Asn Leu Arg Pro Pro Val Pro Pro Pro Gly 
        355                 360                 365             


Pro Leu Pro Pro Ser Leu Pro Pro Val Thr Gly Pro Pro Pro Pro Leu 
    370                 375                 380                 


Pro Pro Leu Gln Pro Ser Gly Met Asp Ala Pro Pro Asn Ser Ala Thr 
385                 390                 395                 400 


Ser Ser Val Pro Thr Val Val Thr Thr Gly Ile His His Gln Pro Pro 
                405                 410                 415     


Pro Ala Pro Pro Ser Leu Phe Thr Ala Asp Thr Tyr Asp Thr Asp Gly 
            420                 425                 430         


Tyr Asn Pro Glu Ala Pro Ser Ile Thr Asn Thr Ser Arg Pro Met Tyr 
        435                 440                 445             


Arg His Arg Val His Ala Gln Arg Pro Asn Leu Ile Gly Leu Thr Ser 
    450                 455                 460                 


Gly Asp Met Asp Leu Pro Pro Arg Glu Lys Pro Pro Asn Lys Ser Ser 
465                 470                 475                 480 


Met Arg Ile Val Val Asp Ser Glu Ser Arg Lys Arg Thr Ile Gly Ser 
                485                 490                 495     


Gly Glu Pro Gly Val Pro Thr Lys Lys Thr Trp Phe Asp Lys Pro Asn 
            500                 505                 510         


Phe Asn Arg Thr Asn Ser Pro Gly Phe Gln Lys Lys Val Gln Phe Gly 
        515                 520                 525             


Asn Glu Asn Thr Lys Leu Glu Leu Arg Lys Val Pro Pro Glu Leu Asn 
    530                 535                 540                 


Asn Ile Ser Lys Leu Asn Glu His Phe Ser Arg Phe Gly Thr Leu Val 
545                 550                 555                 560 


Asn Leu Gln Val Ala Tyr Asn Gly Asp Pro Glu Gly Ala Leu Ile Gln 
                565                 570                 575     


Phe Ala Thr Tyr Glu Glu Ala Lys Lys Ala Ile Ser Ser Thr Glu Ala 
            580                 585                 590         


Val Leu Asn Asn Arg Phe Ile Lys Val Tyr Trp His Arg Glu Gly Ser 
        595                 600                 605             


Thr Gln Gln Leu Gln Thr Thr Ser Pro Lys Pro Leu Val Gln Gln Pro 
    610                 615                 620                 


Ile Leu Pro Val Val Lys Gln Ser Val Lys Glu Arg Leu Gly Pro Val 
625                 630                 635                 640 


Pro Ser Ser Thr Ile Glu Pro Ala Glu Ala Gln Ser Ala Ser Ser Asp 
                645                 650                 655     


Leu Pro Gln Val Leu Ser Thr Ser Thr Gly Leu Thr Lys Thr Val Tyr 
            660                 665                 670         


Asn Pro Ala Ala Leu Lys Ala Ala Gln Lys Thr Leu Leu Val Ser Thr 
        675                 680                 685             


Ser Ala Val Asp Asn Asn Glu Ala Gln Lys Lys Lys Gln Glu Ala Leu 
    690                 695                 700                 


Lys Leu Gln Gln Asp Val Arg Lys Arg Lys Gln Glu Ile Leu Glu Lys 
705                 710                 715                 720 


His Ile Glu Thr Gln Lys Met Leu Ile Ser Lys Leu Glu Lys Asn Lys 
                725                 730                 735     


Thr Met Lys Ser Glu Asp Lys Ala Glu Ile Met Lys Thr Leu Glu Val 
            740                 745                 750         


Leu Thr Lys Asn Ile Thr Lys Leu Lys Asp Glu Val Lys Ala Ala Ser 
        755                 760                 765             


Pro Gly Arg Cys Leu Pro Lys Ser Ile Lys Thr Lys Thr Gln Met Gln 
    770                 775                 780                 


Lys Glu Leu Leu Asp Thr Glu Leu Asp Leu Tyr Lys Lys Met Gln Ala 
785                 790                 795                 800 


Gly Glu Glu Val Thr Glu Leu Arg Arg Lys Tyr Thr Glu Leu Gln Leu 
                805                 810                 815     


Glu Ala Ala Lys Arg Gly Ile Leu Ser Ser Gly Arg Gly Arg Gly Ile 
            820                 825                 830         


His Ser Arg Gly Arg Gly Ala Val His Gly Arg Gly Arg Gly Arg Gly 
        835                 840                 845             


Arg Gly Arg Gly Val Pro Gly His Ala Val Val Asp His Arg Pro Arg 
    850                 855                 860                 


Ala Leu Glu Ile Ser Ala Phe Thr Glu Ser Asp Arg Glu Asp Leu Leu 
865                 870                 875                 880 


Pro His Phe Ala Gln Tyr Gly Glu Ile Glu Asp Cys Gln Ile Asp Asp 
                885                 890                 895     


Ser Ser Leu His Ala Val Ile Thr Phe Lys Thr Arg Ala Glu Ala Glu 
            900                 905                 910         


Ala Ala Ala Val His Gly Ala Arg Phe Lys Gly Gln Asp Leu Lys Leu 
        915                 920                 925             


Ala Trp Asn Lys Pro Val Thr Asn Ile Ser Ala Val Glu Thr Glu Glu 
    930                 935                 940                 


Val Glu Pro Asp Glu Glu Glu Phe Gln Glu Glu Ser Leu Val Asp Asp 
945                 950                 955                 960 


Ser Leu Leu Gln Asp Asp Asp Glu Glu Glu Glu Asp Asn Glu Ser Arg 
                965                 970                 975     


Ser Trp Arg Arg 
            980 


<210>  1529
<211>  551
<212>  PRT
<213>  homo sapiens

<400>  1529

Met Glu Glu Glu Leu Pro Leu Phe Ser Gly Asp Ser Gly Lys Pro Val 
1               5                   10                  15      


Gln Ala Thr Leu Ser Ser Leu Lys Met Leu Asp Val Gly Lys Trp Pro 
            20                  25                  30          


Ile Phe Ser Leu Cys Ser Glu Glu Glu Leu Gln Leu Ile Arg Gln Ala 
        35                  40                  45              


Cys Val Phe Gly Ser Ala Gly Asn Glu Val Leu Tyr Thr Thr Val Asn 
    50                  55                  60                  


Asp Glu Ile Phe Val Leu Gly Thr Asn Cys Cys Gly Cys Leu Gly Leu 
65                  70                  75                  80  


Gly Asp Val Gln Ser Thr Ile Glu Pro Arg Arg Leu Asp Ser Leu Asn 
                85                  90                  95      


Gly Lys Lys Ile Ala Cys Leu Ser Tyr Gly Ser Gly Pro His Ile Val 
            100                 105                 110         


Leu Ala Thr Thr Glu Gly Glu Val Phe Thr Trp Gly His Asn Ala Tyr 
        115                 120                 125             


Ser Gln Leu Gly Asn Gly Thr Thr Asn His Gly Leu Val Pro Cys His 
    130                 135                 140                 


Ile Ser Thr Asn Leu Ser Asn Lys Gln Val Ile Glu Val Ala Cys Gly 
145                 150                 155                 160 


Ser Tyr His Ser Leu Val Leu Thr Ser Asp Gly Glu Val Phe Ala Trp 
                165                 170                 175     


Gly Tyr Asn Asn Ser Gly Gln Val Gly Ser Gly Ser Thr Val Asn Gln 
            180                 185                 190         


Pro Ile Pro Arg Arg Val Thr Gly Cys Leu Gln Asn Lys Val Val Val 
        195                 200                 205             


Thr Ile Ala Cys Gly Gln Met Cys Cys Met Ala Val Val Asp Thr Gly 
    210                 215                 220                 


Glu Val Tyr Val Trp Gly Tyr Asn Gly Asn Gly Gln Leu Gly Leu Gly 
225                 230                 235                 240 


Asn Ser Gly Asn Gln Pro Thr Pro Cys Arg Val Ala Ala Leu Gln Gly 
                245                 250                 255     


Ile Arg Val Gln Arg Val Ala Cys Gly Tyr Ala His Thr Leu Val Leu 
            260                 265                 270         


Thr Asp Glu Gly Gln Val Tyr Ala Trp Gly Ala Asn Ser Tyr Gly Gln 
        275                 280                 285             


Leu Gly Thr Gly Asn Lys Ser Asn Gln Ser Tyr Pro Thr Pro Val Thr 
    290                 295                 300                 


Val Glu Lys Asp Arg Ile Ile Glu Ile Ala Ala Cys His Ser Thr His 
305                 310                 315                 320 


Thr Ser Ala Ala Lys Thr Gln Gly Gly His Val Tyr Met Trp Gly Gln 
                325                 330                 335     


Cys Arg Gly Gln Ser Val Ile Leu Pro His Leu Thr His Phe Ser Cys 
            340                 345                 350         


Thr Asp Asp Val Phe Ala Cys Phe Ala Thr Pro Ala Val Thr Trp Arg 
        355                 360                 365             


Leu Leu Ser Val Glu Pro Asp Asp His Leu Thr Val Ala Glu Ser Leu 
    370                 375                 380                 


Lys Arg Glu Phe Asp Asn Pro Asp Thr Ala Asp Leu Lys Phe Leu Val 
385                 390                 395                 400 


Asp Gly Lys Tyr Ile Tyr Ala His Lys Val Leu Leu Lys Ile Arg Cys 
                405                 410                 415     


Glu His Phe Arg Ser Ser Leu Glu Asp Asn Glu Asp Asp Ile Val Glu 
            420                 425                 430         


Met Ser Glu Phe Ser Tyr Pro Val Tyr Arg Ala Phe Leu Glu Tyr Leu 
        435                 440                 445             


Tyr Thr Asp Ser Ile Ser Leu Ser Pro Glu Glu Ala Val Gly Leu Leu 
    450                 455                 460                 


Asp Leu Ala Thr Phe Tyr Arg Glu Asn Arg Leu Lys Lys Leu Cys Gln 
465                 470                 475                 480 


Gln Thr Ile Lys Gln Gly Ile Cys Glu Glu Asn Ala Ile Ala Leu Leu 
                485                 490                 495     


Ser Ala Ala Val Lys Tyr Asp Ala Gln Asp Leu Glu Glu Phe Cys Phe 
            500                 505                 510         


Arg Phe Cys Ile Asn His Leu Thr Val Val Thr Gln Thr Ser Gly Phe 
        515                 520                 525             


Ala Glu Met Asp His Asp Leu Leu Lys Asn Phe Ile Ser Lys Ala Ser 
    530                 535                 540                 


Arg Val Gly Ala Phe Lys Asn 
545                 550     


<210>  1530
<211>  583
<212>  PRT
<213>  homo sapiens

<400>  1530

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Val Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Val Asp Ser Lys Gly Tyr Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Gln Gln Asp Val Lys Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Phe Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Glu 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Ala Ile Leu Asn 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asn Lys Glu Ile His Lys Pro 
    130                 135                 140                 


Gly Tyr Leu Ala Asn Asp Arg Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Thr Lys Glu Gln Trp Glu Glu Arg Ile Gln Asn Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ser Met Met Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu His Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Ala Gln Leu Glu Asn Glu Lys Lys Lys Arg Glu Ile Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Arg Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Ile Lys Ala Gln Lys Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Lys Ala Leu Glu Leu Asp Gln Glu Arg Lys Arg Ala Lys Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Lys Glu Arg Arg Ala Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Ser Ala Ile Ala Lys Gln Ala Ala Asp Gln Met Lys Asn Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Phe Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Lys Lys Lys Lys Glu Glu Glu Ala Thr Glu Trp Gln His Lys 
        435                 440                 445             


Ala Phe Ala Ala Gln Glu Asp Leu Glu Lys Thr Lys Glu Glu Leu Lys 
    450                 455                 460                 


Thr Val Met Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Val Ile Pro 
465                 470                 475                 480 


Pro Thr Glu Asn Glu His Asp Glu His Asp Glu Asn Asn Ala Glu Ala 
                485                 490                 495     


Ser Ala Glu Leu Ser Asn Glu Gly Val Met Asn His Arg Ser Glu Glu 
            500                 505                 510         


Glu Arg Val Thr Glu Thr Gln Lys Asn Glu Arg Val Lys Lys Gln Leu 
        515                 520                 525             


Gln Ala Leu Ser Ser Glu Leu Ala Gln Ala Arg Asp Glu Thr Lys Lys 
    530                 535                 540                 


Thr Gln Asn Asp Val Leu His Ala Glu Asn Val Lys Ala Gly Arg Asp 
545                 550                 555                 560 


Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg 
                565                 570                 575     


Ile Asp Glu Phe Glu Ala Met 
            580             


<210>  1531
<211>  795
<212>  PRT
<213>  homo sapiens

<400>  1531

Met Glu Gly Leu Thr Leu Ser Asp Ala Glu Gln Lys Tyr Tyr Ser Asp 
1               5                   10                  15      


Leu Phe Ser Tyr Cys Asp Ile Glu Ser Thr Lys Lys Val Val Val Asn 
            20                  25                  30          


Gly Arg Val Leu Glu Leu Phe Arg Ala Ala Gln Leu Pro Asn Asp Val 
        35                  40                  45              


Val Leu Gln Ile Met Glu Leu Cys Gly Ala Thr Arg Leu Gly Tyr Phe 
    50                  55                  60                  


Gly Arg Ser Gln Phe Tyr Ile Ala Leu Lys Leu Val Ala Val Ala Gln 
65                  70                  75                  80  


Ser Gly Phe Pro Leu Arg Val Glu Ser Ile Asn Thr Val Lys Asp Leu 
                85                  90                  95      


Pro Leu Pro Arg Phe Val Ala Ser Lys Asn Glu Gln Glu Ser Arg His 
            100                 105                 110         


Ala Ala Ser Tyr Ser Ser Asp Ser Glu Asn Gln Gly Ser Tyr Ser Gly 
        115                 120                 125             


Val Ile Pro Pro Pro Pro Gly Arg Gly Gln Val Lys Lys Gly Ser Val 
    130                 135                 140                 


Ser His Asp Thr Val Gln Pro Arg Thr Ser Ala Asp Ala Gln Glu Pro 
145                 150                 155                 160 


Ala Ser Pro Val Val Ser Pro Gln Gln Ser Pro Pro Thr Ser Pro His 
                165                 170                 175     


Thr Trp Arg Lys His Ser Arg His Pro Ser Gly Gly Asn Ser Glu Arg 
            180                 185                 190         


Pro Leu Ala Gly Pro Gly Pro Phe Trp Ser Pro Phe Gly Glu Ala Gln 
        195                 200                 205             


Ser Gly Ser Ser Ala Gly Asp Ala Val Trp Ser Gly His Ser Pro Pro 
    210                 215                 220                 


Pro Pro Gln Glu Asn Trp Val Ser Phe Ala Asp Thr Pro Pro Thr Ser 
225                 230                 235                 240 


Thr Leu Leu Thr Met His Pro Ala Ser Val Gln Asp Gln Thr Thr Val 
                245                 250                 255     


Arg Thr Val Ala Ser Ala Thr Thr Ala Ile Glu Ile Arg Arg Gln Ser 
            260                 265                 270         


Ser Ser Tyr Asp Asp Pro Trp Lys Ile Thr Asp Glu Gln Arg Gln Tyr 
        275                 280                 285             


Tyr Val Asn Gln Phe Lys Thr Ile Gln Pro Asp Leu Asn Gly Phe Ile 
    290                 295                 300                 


Pro Gly Ser Ala Ala Lys Glu Phe Phe Thr Lys Ser Lys Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Leu Ser His Ile Trp Glu Leu Ser Asp Phe Asp Lys Asp Gly 
                325                 330                 335     


Ala Leu Thr Leu Asp Glu Phe Cys Ala Ala Phe His Leu Val Val Ala 
            340                 345                 350         


Arg Lys Asn Gly Tyr Asp Leu Pro Glu Lys Leu Pro Glu Ser Leu Met 
        355                 360                 365             


Pro Lys Leu Ile Asp Leu Glu Asp Ser Ala Asp Val Gly Asp Gln Pro 
    370                 375                 380                 


Gly Glu Val Gly Tyr Ser Gly Ser Pro Ala Glu Ala Pro Pro Ser Lys 
385                 390                 395                 400 


Ser Pro Ser Met Pro Ser Leu Asn Gln Thr Trp Pro Glu Leu Asn Gln 
                405                 410                 415     


Ser Ser Glu Gln Trp Glu Thr Phe Ser Glu Arg Ser Ser Ser Ser Gln 
            420                 425                 430         


Thr Leu Thr Gln Phe Asp Ser Asn Ile Ala Pro Ala Asp Pro Asp Thr 
        435                 440                 445             


Ala Ile Val His Pro Val Pro Ile Arg Met Thr Pro Ser Lys Ile His 
    450                 455                 460                 


Met Gln Glu Met Glu Leu Lys Arg Thr Gly Ser Asp His Thr Asn Pro 
465                 470                 475                 480 


Thr Ser Pro Leu Leu Val Lys Pro Ser Asp Leu Leu Glu Glu Asn Lys 
                485                 490                 495     


Ile Asn Ser Ser Val Lys Phe Ala Ser Gly Asn Thr Val Asp Gly Tyr 
            500                 505                 510         


Ser Ser Ser Asp Ser Phe Thr Ser Asp Pro Glu Gln Ile Gly Ser Asn 
        515                 520                 525             


Val Thr Arg Gln Arg Ser His Ser Gly Thr Ser Pro Asp Asn Thr Ala 
    530                 535                 540                 


Pro Pro Pro Pro Pro Pro Arg Pro Gln Pro Ser His Ser Arg Ser Ser 
545                 550                 555                 560 


Ser Leu Asp Met Asn Arg Thr Phe Thr Val Thr Thr Gly Gln Gln Gln 
                565                 570                 575     


Ala Gly Val Val Ala His Pro Pro Ala Val Pro Pro Arg Pro Gln Pro 
            580                 585                 590         


Ser Gln Ala Pro Gly Pro Ala Val His Arg Pro Val Asp Ala Asp Gly 
        595                 600                 605             


Leu Ile Thr His Thr Ser Thr Ser Pro Gln Gln Ile Pro Glu Gln Pro 
    610                 615                 620                 


Asn Phe Ala Asp Phe Ser Gln Phe Glu Val Phe Ala Ala Ser Asn Val 
625                 630                 635                 640 


Asn Asp Glu Gln Asp Asp Glu Ala Glu Lys His Pro Glu Val Leu Pro 
                645                 650                 655     


Ala Glu Lys Ala Ser Asp Pro Ala Ser Ser Leu Arg Val Ala Lys Thr 
            660                 665                 670         


Asp Ser Lys Thr Glu Glu Lys Thr Ala Ala Ser Ala Pro Ala Asn Val 
        675                 680                 685             


Ser Lys Gly Thr Thr Pro Leu Ala Pro Pro Pro Lys Pro Val Arg Arg 
    690                 695                 700                 


Arg Leu Lys Ser Glu Asp Glu Leu Arg Pro Glu Val Asp Glu His Thr 
705                 710                 715                 720 


Gln Lys Thr Gly Val Leu Ala Ala Val Leu Ala Ser Gln Pro Ser Ile 
                725                 730                 735     


Pro Arg Ser Val Gly Lys Asp Lys Lys Ala Ile Gln Ala Ser Ile Arg 
            740                 745                 750         


Arg Asn Lys Glu Thr Asn Thr Val Leu Ala Arg Leu Asn Ser Glu Leu 
        755                 760                 765             


Gln Gln Gln Leu Lys Asp Val Leu Glu Glu Arg Ile Ser Leu Glu Val 
    770                 775                 780                 


Gln Leu Glu Gln Leu Arg Pro Phe Ser His Leu 
785                 790                 795 


<210>  1532
<211>  1147
<212>  PRT
<213>  homo sapiens

<400>  1532

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
1               5                   10                  15      


Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
            20                  25                  30          


Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
        35                  40                  45              


Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
    50                  55                  60                  


Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
65                  70                  75                  80  


Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                85                  90                  95      


Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
            100                 105                 110         


Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
        115                 120                 125             


Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
    130                 135                 140                 


Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
145                 150                 155                 160 


Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                165                 170                 175     


Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
            180                 185                 190         


Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
        195                 200                 205             


Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
    210                 215                 220                 


Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
225                 230                 235                 240 


Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                245                 250                 255     


Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
            260                 265                 270         


Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
        275                 280                 285             


Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
    290                 295                 300                 


Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
305                 310                 315                 320 


Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                325                 330                 335     


Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
            340                 345                 350         


Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
        355                 360                 365             


Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
    370                 375                 380                 


Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
385                 390                 395                 400 


Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                405                 410                 415     


Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
            420                 425                 430         


Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
        435                 440                 445             


Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
    450                 455                 460                 


Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
465                 470                 475                 480 


Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                485                 490                 495     


Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
            500                 505                 510         


Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
        515                 520                 525             


Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
    530                 535                 540                 


Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
545                 550                 555                 560 


Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                565                 570                 575     


Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
            580                 585                 590         


Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
        595                 600                 605             


Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
    610                 615                 620                 


Asp Lys Lys His Ala Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp Gly 
625                 630                 635                 640 


Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
                645                 650                 655     


Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
            660                 665                 670         


Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala Ile 
        675                 680                 685             


Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser Asn 
    690                 695                 700                 


Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp Glu 
705                 710                 715                 720 


Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
                725                 730                 735     


Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
            740                 745                 750         


Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
        755                 760                 765             


Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met Met 
    770                 775                 780                 


Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
785                 790                 795                 800 


Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His Asn 
                805                 810                 815     


Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln Ala 
            820                 825                 830         


Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro Phe 
        835                 840                 845             


Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His Met 
    850                 855                 860                 


Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
865                 870                 875                 880 


Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala Ala 
                885                 890                 895     


Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
            900                 905                 910         


Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys Gln 
        915                 920                 925             


Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu Pro 
    930                 935                 940                 


Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro Ser 
945                 950                 955                 960 


Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val Gln 
                965                 970                 975     


Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
            980                 985                 990         


Val Asn Met Asp Tyr Leu Ser Leu  Leu Arg Asp Ala Leu  Val Gln Pro 
        995                 1000                 1005             


Leu Thr  Ser Gln Gly Val Asp  Gly Val Gln Asp Val  Val Ala Leu 
    1010                 1015                 1020             


Met Asp  Thr Tyr Tyr Leu Met  Lys Glu Asp Phe Glu  Asn Ile Met 
    1025                 1030                 1035             


Glu Ile  Ser Ser Trp Gly Gly  Lys Pro Ser Pro Phe  Ser Lys Leu 
    1040                 1045                 1050             


Asp Pro  Lys Val Lys Ala Ala  Phe Thr Arg Ala Tyr  Asn Lys Glu 
    1055                 1060                 1065             


Ala His  Leu Thr Pro Tyr Ser  Leu Gln Ala Ile Lys  Ala Ser Arg 
    1070                 1075                 1080             


His Ser  Thr Ser Pro Ser Leu  Asp Ser Glu Tyr Asn  Glu Glu Leu 
    1085                 1090                 1095             


Asn Glu  Asp Asp Ser Gln Ser  Asp Glu Lys Asp Gln  Asp Ala Ile 
    1100                 1105                 1110             


Glu Thr  Asp Ala Met Ile Lys  Lys Lys Thr Lys Ser  Ser Lys Pro 
    1115                 1120                 1125             


Ser Lys  Pro Glu Lys Asp Lys  Glu Pro Arg Lys Gly  Lys Gly Lys 
    1130                 1135                 1140             


Ser Ser  Lys Lys 
    1145         


<210>  1533
<211>  211
<212>  PRT
<213>  homo sapiens

<400>  1533

Met Gln Ser Ala Met Phe Leu Ala Val Gln His Asp Cys Arg Pro Met 
1               5                   10                  15      


Asp Lys Ser Ala Gly Ser Gly His Lys Ser Glu Glu Lys Arg Glu Lys 
            20                  25                  30          


Met Lys Arg Thr Leu Leu Lys Asp Trp Lys Thr Arg Leu Ser Tyr Phe 
        35                  40                  45              


Leu Gln Asn Ser Ser Thr Pro Gly Lys Pro Lys Thr Gly Lys Lys Ser 
    50                  55                  60                  


Lys Gln Gln Ala Phe Ile Lys Pro Ser Pro Glu Glu Ala Gln Leu Trp 
65                  70                  75                  80  


Ser Glu Ala Phe Asp Glu Leu Leu Ala Ser Lys Tyr Gly Leu Ala Ala 
                85                  90                  95      


Phe Arg Ala Phe Leu Lys Ser Glu Phe Cys Glu Glu Asn Ile Glu Phe 
            100                 105                 110         


Trp Leu Ala Cys Glu Asp Phe Lys Lys Thr Lys Ser Pro Gln Lys Leu 
        115                 120                 125             


Ser Ser Lys Ala Arg Lys Ile Tyr Thr Asp Phe Ile Glu Lys Glu Ala 
    130                 135                 140                 


Pro Lys Glu Ile Asn Ile Asp Phe Gln Thr Lys Thr Leu Ile Ala Gln 
145                 150                 155                 160 


Asn Ile Gln Glu Ala Thr Ser Gly Cys Phe Thr Thr Ala Gln Lys Arg 
                165                 170                 175     


Val Tyr Ser Leu Met Glu Asn Asn Ser Tyr Pro Arg Phe Leu Glu Ser 
            180                 185                 190         


Glu Phe Tyr Gln Asp Leu Cys Lys Lys Pro Gln Ile Thr Thr Glu Pro 
        195                 200                 205             


His Ala Thr 
    210     


<210>  1534
<211>  552
<212>  PRT
<213>  homo sapiens

<400>  1534

Met Gly Lys Val Asn Val Ala Lys Leu Arg Tyr Met Ser Arg Asp Asp 
1               5                   10                  15      


Phe Arg Val Leu Thr Ala Val Glu Met Gly Met Lys Asn His Glu Ile 
            20                  25                  30          


Val Pro Gly Ser Leu Ile Ala Ser Ile Ala Ser Leu Lys His Gly Gly 
        35                  40                  45              


Cys Asn Lys Val Leu Arg Glu Leu Val Lys His Lys Leu Ile Ala Trp 
    50                  55                  60                  


Glu Arg Thr Lys Thr Val Gln Gly Tyr Arg Leu Thr Asn Ala Gly Tyr 
65                  70                  75                  80  


Asp Tyr Leu Ala Leu Lys Thr Leu Ser Ser Arg Gln Val Val Glu Ser 
                85                  90                  95      


Val Gly Asn Gln Met Gly Val Gly Lys Glu Ser Asp Ile Tyr Ile Val 
            100                 105                 110         


Ala Asn Glu Glu Gly Gln Gln Phe Ala Leu Lys Leu His Arg Leu Gly 
        115                 120                 125             


Arg Thr Ser Phe Arg Asn Leu Lys Asn Lys Arg Asp Tyr His Lys His 
    130                 135                 140                 


Arg His Asn Val Ser Trp Leu Tyr Leu Ser Arg Leu Ser Ala Met Lys 
145                 150                 155                 160 


Glu Phe Ala Tyr Met Lys Ala Leu Tyr Glu Arg Lys Phe Pro Val Pro 
                165                 170                 175     


Lys Pro Ile Asp Tyr Asn Arg His Ala Val Val Met Glu Leu Ile Asn 
            180                 185                 190         


Gly Tyr Pro Leu Cys Gln Ile His His Val Glu Asp Pro Ala Ser Val 
        195                 200                 205             


Tyr Asp Glu Ala Met Glu Leu Ile Val Lys Leu Ala Asn His Gly Leu 
    210                 215                 220                 


Ile His Gly Asp Phe Asn Glu Phe Asn Leu Ile Leu Asp Glu Ser Asp 
225                 230                 235                 240 


His Ile Thr Met Ile Asp Phe Pro Gln Met Val Ser Thr Ser His Pro 
                245                 250                 255     


Asn Ala Glu Trp Tyr Phe Asp Arg Asp Val Lys Cys Ile Lys Asp Phe 
            260                 265                 270         


Phe Met Lys Arg Phe Ser Tyr Glu Ser Glu Leu Phe Pro Thr Phe Lys 
        275                 280                 285             


Asp Ile Arg Arg Glu Asp Thr Leu Asp Val Glu Val Ser Ala Ser Gly 
    290                 295                 300                 


Tyr Thr Lys Glu Met Gln Ala Asp Asp Glu Leu Leu His Pro Leu Gly 
305                 310                 315                 320 


Pro Asp Asp Lys Asn Ile Glu Thr Lys Glu Gly Ser Glu Phe Ser Phe 
                325                 330                 335     


Ser Asp Gly Glu Val Ala Glu Lys Ala Glu Val Tyr Gly Ser Glu Asn 
            340                 345                 350         


Glu Ser Glu Arg Asn Cys Leu Glu Glu Ser Glu Gly Cys Tyr Cys Arg 
        355                 360                 365             


Ser Ser Gly Asp Pro Glu Gln Ile Lys Glu Asp Ser Leu Ser Glu Glu 
    370                 375                 380                 


Ser Ala Asp Ala Arg Ser Phe Glu Met Thr Glu Phe Asn Gln Ala Leu 
385                 390                 395                 400 


Glu Glu Ile Lys Gly Gln Val Val Glu Asn Asn Ser Val Thr Glu Phe 
                405                 410                 415     


Ser Glu Glu Lys Asn Arg Thr Glu Asn Tyr Asn Arg Gln Asp Gly Gln 
            420                 425                 430         


Arg Val Gln Gly Gly Val Pro Ala Gly Ser Asp Glu Tyr Glu Asp Glu 
        435                 440                 445             


Cys Pro His Leu Ile Ala Leu Ser Ser Leu Asn Arg Glu Phe Arg Pro 
    450                 455                 460                 


Phe Arg Asp Glu Glu Asn Val Gly Ala Met Asn Gln Tyr Arg Thr Arg 
465                 470                 475                 480 


Thr Leu Ser Ile Thr Ser Ser Gly Ser Ala Val Ser Cys Ser Thr Ile 
                485                 490                 495     


Pro Pro Glu Leu Val Lys Gln Lys Val Lys Arg Gln Leu Thr Lys Gln 
            500                 505                 510         


Gln Lys Ser Ala Val Arg Arg Arg Leu Gln Lys Gly Glu Ala Asn Ile 
        515                 520                 525             


Phe Thr Lys Gln Arg Arg Glu Asn Met Gln Asn Ile Lys Ser Ser Leu 
    530                 535                 540                 


Glu Ala Ala Ser Phe Trp Gly Glu 
545                 550         


<210>  1535
<211>  449
<212>  PRT
<213>  homo sapiens

<400>  1535

Met Pro Ala Thr Leu Leu Arg Ala Val Ala Arg Ser His His Ile Leu 
1               5                   10                  15      


Ser Lys Ala His Gln Cys Arg Arg Ile Gly His Leu Met Leu Lys Pro 
            20                  25                  30          


Leu Lys Glu Phe Glu Asn Thr Thr Cys Ser Thr Leu Thr Ile Arg Gln 
        35                  40                  45              


Ser Leu Asp Leu Phe Leu Pro Asp Lys Thr Ala Ser Gly Leu Asn Lys 
    50                  55                  60                  


Ser Gln Ile Leu Glu Met Asn Gln Lys Lys Ser Asp Thr Ser Met Leu 
65                  70                  75                  80  


Ser Pro Leu Asn Ala Ala Arg Cys Gln Asp Glu Lys Ala His Leu Pro 
                85                  90                  95      


Thr Met Lys Ser Phe Gly Thr His Arg Arg Val Thr His Lys Pro Asn 
            100                 105                 110         


Leu Leu Gly Ser Lys Trp Phe Ile Lys Ile Leu Lys Arg His Phe Ser 
        115                 120                 125             


Ser Val Ser Thr Glu Thr Phe Val Pro Lys Gln Asp Phe Pro Gln Val 
    130                 135                 140                 


Lys Arg Pro Leu Lys Ala Ser Arg Thr Arg Gln Pro Ser Arg Thr Asn 
145                 150                 155                 160 


Leu Pro Val Leu Ser Val Asn Glu Asp Leu Met His Cys Thr Ala Phe 
                165                 170                 175     


Ala Thr Ala Asp Glu Tyr His Leu Gly Asn Leu Ser Gln Asp Leu Ala 
            180                 185                 190         


Ser His Gly Tyr Val Glu Val Thr Ser Leu Pro Arg Asp Ala Ala Asn 
        195                 200                 205             


Ile Leu Val Met Gly Val Glu Asn Ser Ala Lys Glu Gly Asp Pro Gly 
    210                 215                 220                 


Thr Ile Phe Phe Phe Arg Glu Gly Ala Ala Val Phe Trp Asn Val Lys 
225                 230                 235                 240 


Asp Lys Thr Met Lys His Val Met Lys Val Leu Glu Lys His Glu Ile 
                245                 250                 255     


Gln Pro Tyr Glu Ile Ala Leu Val His Trp Glu Asn Glu Glu Leu Asn 
            260                 265                 270         


Tyr Ile Lys Ile Glu Gly Gln Ser Lys Leu His Arg Gly Glu Ile Lys 
        275                 280                 285             


Leu Asn Ser Glu Leu Asp Leu Asp Asp Ala Ile Leu Glu Lys Phe Ala 
    290                 295                 300                 


Phe Ser Asn Ala Leu Cys Leu Ser Val Lys Leu Ala Ile Trp Glu Ala 
305                 310                 315                 320 


Ser Leu Asp Lys Phe Ile Glu Ser Ile Gln Ser Ile Pro Glu Ala Leu 
                325                 330                 335     


Lys Ala Gly Lys Lys Val Lys Leu Ser His Glu Glu Val Met Gln Lys 
            340                 345                 350         


Ile Gly Glu Leu Phe Ala Leu Arg His Arg Ile Asn Leu Ser Ser Asp 
        355                 360                 365             


Phe Leu Ile Thr Pro Asp Phe Tyr Trp Asp Arg Glu Asn Leu Glu Gly 
    370                 375                 380                 


Leu Tyr Asp Lys Thr Cys Gln Phe Leu Ser Ile Gly Arg Arg Val Lys 
385                 390                 395                 400 


Val Met Asn Glu Lys Leu Gln His Cys Met Glu Leu Thr Asp Leu Met 
                405                 410                 415     


Arg Asn His Leu Asn Glu Lys Arg Ala Leu Arg Leu Glu Trp Met Ile 
            420                 425                 430         


Val Ile Leu Ile Thr Ile Glu Val Met Phe Glu Leu Gly Arg Val Phe 
        435                 440                 445             


Phe 
    


<210>  1536
<211>  258
<212>  PRT
<213>  homo sapiens

<400>  1536

Met Ala Lys Tyr Gln Gly Glu Val Gln Ser Leu Lys Leu Asp Asp Asp 
1               5                   10                  15      


Ser Val Ile Glu Gly Val Ser Asp Gln Val Leu Val Ala Val Val Val 
            20                  25                  30          


Ser Phe Ala Leu Ile Ala Thr Leu Val Tyr Ala Leu Phe Arg Asn Val 
        35                  40                  45              


His Gln Asn Ile His Pro Glu Asn Gln Glu Leu Val Arg Val Leu Arg 
    50                  55                  60                  


Glu Gln Leu Gln Thr Glu Gln Asp Ala Pro Ala Ala Thr Arg Gln Gln 
65                  70                  75                  80  


Phe Tyr Thr Asp Met Tyr Cys Pro Ile Cys Leu His Gln Ala Ser Phe 
                85                  90                  95      


Pro Val Glu Thr Asn Cys Gly His Leu Phe Cys Gly Ala Cys Ile Ile 
            100                 105                 110         


Ala Tyr Trp Arg Tyr Gly Ser Trp Leu Gly Ala Ile Ser Cys Pro Ile 
        115                 120                 125             


Cys Arg Gln Thr Val Thr Leu Leu Leu Thr Val Phe Gly Glu Asp Asp 
    130                 135                 140                 


Gln Ser Gln Asp Val Leu Arg Leu His Gln Asp Ile Asn Asp Tyr Asn 
145                 150                 155                 160 


Arg Arg Phe Ser Gly Gln Pro Arg Ser Ile Met Glu Arg Ile Met Asp 
                165                 170                 175     


Leu Pro Thr Leu Leu Arg His Ala Phe Arg Glu Met Phe Ser Val Gly 
            180                 185                 190         


Gly Leu Phe Trp Met Phe Arg Ile Arg Ile Ile Leu Cys Leu Met Gly 
        195                 200                 205             


Ala Phe Phe Tyr Leu Ile Ser Pro Leu Asp Phe Val Pro Glu Ala Leu 
    210                 215                 220                 


Phe Gly Ile Leu Gly Phe Leu Asp Asp Phe Phe Val Ile Phe Leu Leu 
225                 230                 235                 240 


Leu Ile Tyr Ile Ser Ile Met Tyr Arg Glu Val Ile Thr Gln Arg Leu 
                245                 250                 255     


Thr Arg 
        


<210>  1537
<211>  476
<212>  PRT
<213>  homo sapiens

<400>  1537

Met Ala Asn Ser Ala Lys Ala Glu Glu Tyr Glu Lys Met Ser Leu Glu 
1               5                   10                  15      


Gln Ala Lys Ala Ser Val Asn Ser Glu Thr Glu Ser Ser Phe Asn Ile 
            20                  25                  30          


Asn Glu Asn Thr Thr Ala Ser Gly Thr Gly Leu Ser Glu Lys Thr Ser 
        35                  40                  45              


Val Cys Arg Gln Val Asp Ile Ala Arg Lys Arg Lys Glu Phe Glu Asp 
    50                  55                  60                  


Asp Leu Val Lys Glu Ser Ser Ser Cys Gly Lys Asp Thr Pro Ser Lys 
65                  70                  75                  80  


Lys Arg Lys Leu Asp Pro Glu Ile Val Pro Glu Glu Lys Asp Cys Gly 
                85                  90                  95      


Asp Ala Glu Gly Asn Ser Lys Lys Arg Lys Arg Glu Thr Glu Asp Val 
            100                 105                 110         


Pro Lys Asp Lys Ser Ser Thr Gly Asp Gly Thr Gln Asn Lys Arg Lys 
        115                 120                 125             


Ile Ala Leu Glu Asp Val Pro Glu Lys Gln Lys Asn Leu Glu Glu Gly 
    130                 135                 140                 


His Ser Ser Thr Val Ala Ala His Tyr Asn Glu Leu Gln Glu Val Gly 
145                 150                 155                 160 


Leu Glu Lys Arg Ser Gln Ser Arg Ile Phe Tyr Leu Arg Asn Phe Asn 
                165                 170                 175     


Asn Trp Met Lys Ser Val Leu Ile Gly Glu Phe Leu Glu Lys Val Arg 
            180                 185                 190         


Gln Lys Lys Lys Arg Asp Ile Thr Val Leu Asp Leu Gly Cys Gly Lys 
        195                 200                 205             


Gly Gly Asp Leu Leu Lys Trp Lys Lys Gly Arg Ile Asn Lys Leu Val 
    210                 215                 220                 


Cys Thr Asp Ile Ala Asp Val Ser Val Lys Gln Cys Gln Gln Arg Tyr 
225                 230                 235                 240 


Glu Asp Met Lys Asn Arg Arg Asp Ser Glu Tyr Ile Phe Ser Ala Glu 
                245                 250                 255     


Phe Ile Thr Ala Asp Ser Ser Lys Glu Leu Leu Ile Asp Lys Phe Arg 
            260                 265                 270         


Asp Pro Gln Met Cys Phe Asp Ile Cys Ser Cys Gln Phe Val Cys His 
        275                 280                 285             


Tyr Ser Phe Glu Ser Tyr Glu Gln Ala Asp Met Met Leu Arg Asn Ala 
    290                 295                 300                 


Cys Glu Arg Leu Ser Pro Gly Gly Tyr Phe Ile Gly Thr Thr Pro Asn 
305                 310                 315                 320 


Ser Phe Glu Leu Ile Arg Arg Leu Glu Ala Ser Glu Thr Glu Ser Phe 
                325                 330                 335     


Gly Asn Glu Ile Tyr Thr Val Lys Phe Gln Lys Lys Gly Asp Tyr Pro 
            340                 345                 350         


Leu Phe Gly Cys Lys Tyr Asp Phe Asn Leu Glu Gly Val Val Asp Val 
        355                 360                 365             


Pro Glu Phe Leu Val Tyr Phe Pro Leu Leu Asn Glu Met Ala Lys Lys 
    370                 375                 380                 


Tyr Asn Met Lys Leu Val Tyr Lys Lys Thr Phe Leu Glu Phe Tyr Glu 
385                 390                 395                 400 


Glu Lys Ile Lys Asn Asn Glu Asn Lys Met Leu Leu Lys Arg Met Gln 
                405                 410                 415     


Ala Leu Glu Pro Tyr Pro Ala Asn Glu Ser Ser Lys Leu Val Ser Glu 
            420                 425                 430         


Lys Val Asp Asp Tyr Glu His Ala Ala Lys Tyr Met Lys Asn Ser Gln 
        435                 440                 445             


Val Arg Leu Pro Leu Gly Thr Leu Ser Lys Ser Glu Trp Glu Ala Thr 
    450                 455                 460                 


Ser Ile Tyr Leu Val Phe Ala Phe Glu Lys Gln Gln 
465                 470                 475     


<210>  1538
<211>  399
<212>  PRT
<213>  homo sapiens

<400>  1538

Met Ser Leu Gln Tyr Gly Ala Glu Glu Thr Pro Leu Ala Gly Ser Tyr 
1               5                   10                  15      


Gly Ala Ala Asp Ser Phe Pro Lys Asp Phe Gly Tyr Gly Val Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Ala Ala Ala Ala Gly Gly Gly Val Gly Ala Gly Ala 
        35                  40                  45              


Gly Gly Gly Cys Gly Pro Gly Gly Ala Asp Ser Ser Lys Pro Arg Ile 
    50                  55                  60                  


Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys Val 
65                  70                  75                  80  


Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser Thr 
                85                  90                  95      


Asn Lys Ile Tyr Lys Asp Asp Ile Ser Asn Ser Ser Phe Val Asn Phe 
            100                 105                 110         


Gln Ile Trp Asp Phe Pro Gly Gln Met Asp Phe Phe Asp Pro Thr Phe 
        115                 120                 125             


Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Tyr Val Ile 
    130                 135                 140                 


Asp Ala Gln Asp Asp Tyr Met Glu Ala Leu Thr Arg Leu His Ile Thr 
145                 150                 155                 160 


Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn Phe Glu Val Phe 
                165                 170                 175     


Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr Gln 
            180                 185                 190         


Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly Leu 
        195                 200                 205             


Glu Lys Leu His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His Ser 
    210                 215                 220                 


Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln Leu 
225                 230                 235                 240 


Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly Ile 
                245                 250                 255     


Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala Thr 
            260                 265                 270         


Asp Ser Ser Pro Val Asp Met Gln Ser Tyr Glu Leu Cys Cys Asp Met 
        275                 280                 285             


Ile Asp Val Val Ile Asp Val Ser Cys Ile Tyr Gly Leu Lys Glu Asp 
    290                 295                 300                 


Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile Ile Lys Leu 
305                 310                 315                 320 


Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu Ala 
                325                 330                 335     


Leu Val Cys Ile Leu Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu Ile 
            340                 345                 350         


Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe Glu 
        355                 360                 365             


Val Gly Val Thr Ser His Arg Ser Cys Gly His Gln Thr Ser Ala Ser 
    370                 375                 380                 


Ser Leu Lys Ala Leu Thr His Asn Gly Thr Pro Arg Asn Ala Ile 
385                 390                 395                 


<210>  1539
<211>  408
<212>  PRT
<213>  homo sapiens

<400>  1539

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15      


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30          


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45              


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60                  


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80  


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95      


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110         


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125             


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140                 


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175     


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190         


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205             


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220                 


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240 


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255     


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270         


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285             


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300                 


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320 


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335     


Glu Asp Thr Asn Gln Gly Ile Ser Gly Glu Leu Cys Ala Leu Met Asp 
            340                 345                 350         


Gln Val His His Met Gln His Ser Lys Trp Gln His Pro Ser Asp Leu 
        355                 360                 365             


Thr Thr Arg Asn Tyr Ala Arg Arg Gln Lys His Leu Gln Arg Tyr Ser 
    370                 375                 380                 


Leu Thr Gln Trp Val Asp Arg Asn Met Arg Ser His His Arg Phe Gln 
385                 390                 395                 400 


Arg Leu Pro Asp Phe Ser Tyr Ser 
                405             


<210>  1540
<211>  832
<212>  PRT
<213>  homo sapiens

<400>  1540

Met Phe Ala Leu Gly Leu Pro Phe Leu Val Leu Leu Val Ala Ser Val 
1               5                   10                  15      


Glu Ser His Leu Gly Val Leu Gly Pro Lys Asn Val Ser Gln Lys Asp 
            20                  25                  30          


Ala Glu Phe Glu Arg Thr Tyr Val Asp Glu Val Asn Ser Glu Leu Val 
        35                  40                  45              


Asn Ile Tyr Thr Phe Asn His Thr Val Thr Arg Asn Arg Thr Glu Gly 
    50                  55                  60                  


Val Arg Val Ser Val Asn Val Leu Asn Lys Gln Lys Gly Ala Pro Leu 
65                  70                  75                  80  


Leu Phe Val Val Arg Gln Lys Glu Ala Val Val Ser Phe Gln Val Pro 
                85                  90                  95      


Leu Ile Leu Arg Gly Met Phe Gln Arg Lys Tyr Leu Tyr Gln Lys Val 
            100                 105                 110         


Glu Arg Thr Leu Cys Gln Pro Pro Thr Lys Asn Glu Ser Glu Ile Gln 
        115                 120                 125             


Phe Phe Tyr Val Asp Val Ser Thr Leu Ser Pro Val Asn Thr Thr Tyr 
    130                 135                 140                 


Gln Leu Arg Val Ser Arg Met Asp Asp Phe Val Leu Arg Thr Gly Glu 
145                 150                 155                 160 


Gln Phe Ser Phe Asn Thr Thr Ala Ala Gln Pro Gln Tyr Phe Lys Tyr 
                165                 170                 175     


Glu Phe Pro Glu Gly Val Asp Ser Val Ile Val Lys Val Thr Ser Asn 
            180                 185                 190         


Lys Ala Phe Pro Cys Ser Val Ile Ser Ile Gln Asp Val Leu Cys Pro 
        195                 200                 205             


Val Tyr Asp Leu Asp Asn Asn Val Ala Phe Ile Gly Met Tyr Gln Thr 
    210                 215                 220                 


Met Thr Lys Lys Ala Ala Ile Thr Val Gln Arg Lys Asp Phe Pro Ser 
225                 230                 235                 240 


Asn Ser Phe Tyr Val Val Val Val Val Lys Thr Glu Asp Gln Ala Cys 
                245                 250                 255     


Gly Gly Ser Leu Pro Phe Tyr Pro Phe Ala Glu Asp Glu Pro Val Asp 
            260                 265                 270         


Gln Gly His Arg Gln Lys Thr Leu Ser Val Leu Val Ser Gln Ala Val 
        275                 280                 285             


Thr Ser Glu Ala Tyr Val Ser Gly Met Leu Phe Cys Leu Gly Ile Phe 
    290                 295                 300                 


Leu Ser Phe Tyr Leu Leu Thr Val Leu Leu Ala Cys Trp Glu Asn Trp 
305                 310                 315                 320 


Arg Gln Lys Lys Lys Thr Leu Leu Val Ala Ile Asp Arg Ala Cys Pro 
                325                 330                 335     


Glu Ser Gly His Pro Arg Val Leu Ala Asp Ser Phe Pro Gly Ser Ser 
            340                 345                 350         


Pro Tyr Glu Gly Tyr Asn Tyr Gly Ser Phe Glu Asn Val Ser Gly Ser 
        355                 360                 365             


Thr Asp Gly Leu Val Asp Ser Ala Gly Thr Gly Asp Leu Ser Tyr Gly 
    370                 375                 380                 


Tyr Gln Gly Arg Ser Phe Glu Pro Val Gly Thr Arg Pro Arg Val Asp 
385                 390                 395                 400 


Ser Met Ser Ser Val Glu Glu Asp Asp Tyr Asp Thr Leu Thr Asp Ile 
                405                 410                 415     


Asp Ser Asp Lys Asn Val Ile Arg Thr Lys Gln Tyr Leu Tyr Val Ala 
            420                 425                 430         


Asp Leu Ala Arg Lys Asp Lys Arg Val Leu Arg Lys Lys Tyr Gln Ile 
        435                 440                 445             


Tyr Phe Trp Asn Ile Ala Thr Ile Ala Val Phe Tyr Ala Leu Pro Val 
    450                 455                 460                 


Val Gln Leu Val Ile Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn 
465                 470                 475                 480 


Gln Asp Ile Cys Tyr Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Asn 
                485                 490                 495     


Leu Ser Ala Phe Asn Asn Ile Leu Ser Asn Leu Gly Tyr Ile Leu Leu 
            500                 505                 510         


Gly Leu Leu Phe Leu Leu Ile Ile Leu Gln Arg Glu Ile Asn His Asn 
        515                 520                 525             


Arg Ala Leu Leu Arg Asn Asp Leu Cys Ala Leu Glu Cys Gly Ile Pro 
    530                 535                 540                 


Lys His Phe Gly Leu Phe Tyr Ala Met Gly Thr Ala Leu Met Met Glu 
545                 550                 555                 560 


Gly Leu Leu Ser Ala Cys Tyr His Val Cys Pro Asn Tyr Thr Asn Phe 
                565                 570                 575     


Gln Phe Asp Thr Ser Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu 
            580                 585                 590         


Lys Leu Tyr Gln Lys Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser 
        595                 600                 605             


Ala Tyr Ala Cys Leu Ala Ile Val Ile Phe Phe Ser Val Leu Gly Val 
    610                 615                 620                 


Val Phe Gly Lys Gly Asn Thr Ala Phe Trp Ile Val Phe Ser Ile Ile 
625                 630                 635                 640 


His Ile Ile Ala Thr Leu Leu Leu Ser Thr Gln Leu Tyr Tyr Met Gly 
                645                 650                 655     


Arg Trp Lys Leu Asp Ser Gly Ile Phe Arg Arg Ile Leu His Val Leu 
            660                 665                 670         


Tyr Thr Asp Cys Ile Arg Gln Cys Ser Gly Pro Leu Tyr Val Asp Arg 
        675                 680                 685             


Met Val Leu Leu Val Met Gly Asn Val Ile Asn Trp Ser Leu Ala Ala 
    690                 695                 700                 


Tyr Gly Leu Ile Met Arg Pro Asn Asp Phe Ala Ser Tyr Leu Leu Ala 
705                 710                 715                 720 


Ile Gly Ile Cys Asn Leu Leu Leu Tyr Phe Ala Phe Tyr Ile Ile Met 
                725                 730                 735     


Lys Leu Arg Ser Gly Glu Arg Ile Lys Leu Ile Pro Leu Leu Cys Ile 
            740                 745                 750         


Val Cys Thr Ser Val Val Trp Gly Phe Ala Leu Phe Phe Phe Phe Gln 
        755                 760                 765             


Gly Leu Ser Thr Trp Gln Lys Thr Pro Ala Glu Ser Arg Glu His Asn 
    770                 775                 780                 


Arg Asp Cys Ile Leu Leu Asp Phe Phe Asp Asp His Asp Ile Trp His 
785                 790                 795                 800 


Phe Leu Ser Ser Ile Ala Met Phe Gly Ser Phe Leu Val Leu Leu Thr 
                805                 810                 815     


Leu Asp Asp Asp Leu Asp Thr Val Gln Arg Asp Lys Ile Tyr Val Phe 
            820                 825                 830         


<210>  1541
<211>  325
<212>  PRT
<213>  homo sapiens

<400>  1541

Met Phe Ala Asn Leu Lys Tyr Val Ser Leu Gly Ile Leu Val Phe Gln 
1               5                   10                  15      


Thr Thr Ser Leu Val Leu Thr Met Arg Tyr Ser Arg Thr Leu Lys Glu 
            20                  25                  30          


Glu Gly Pro Arg Tyr Leu Ser Ser Thr Ala Val Val Val Ala Glu Leu 
        35                  40                  45              


Leu Lys Ile Met Ala Cys Ile Leu Leu Val Tyr Lys Asp Ser Lys Cys 
    50                  55                  60                  


Ser Leu Arg Ala Leu Asn Arg Val Leu His Asp Glu Ile Leu Asn Lys 
65                  70                  75                  80  


Pro Met Glu Thr Leu Lys Leu Ala Ile Pro Ser Gly Ile Tyr Thr Leu 
                85                  90                  95      


Gln Asn Asn Leu Leu Tyr Val Ala Leu Ser Asn Leu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Gln Val Thr Tyr Gln Leu Lys Ile Leu Thr Thr Ala Leu Phe Ser 
        115                 120                 125             


Val Ser Met Leu Ser Lys Lys Leu Gly Val Tyr Gln Trp Leu Ser Leu 
    130                 135                 140                 


Val Ile Leu Met Thr Gly Val Ala Phe Val Gln Trp Pro Ser Asp Ser 
145                 150                 155                 160 


Gln Leu Asp Ser Lys Glu Leu Ser Ala Gly Ser Gln Phe Val Gly Leu 
                165                 170                 175     


Met Ala Val Leu Thr Ala Cys Phe Ser Ser Gly Phe Ala Gly Val Tyr 
            180                 185                 190         


Phe Glu Lys Ile Leu Lys Glu Thr Lys Gln Ser Val Trp Ile Arg Asn 
        195                 200                 205             


Ile Gln Leu Gly Phe Phe Gly Ser Ile Phe Gly Leu Met Gly Val Tyr 
    210                 215                 220                 


Ile Tyr Asp Gly Glu Leu Val Ser Lys Asn Gly Phe Phe Gln Gly Tyr 
225                 230                 235                 240 


Asn Arg Leu Thr Trp Ile Val Val Val Leu Gln Ala Leu Gly Gly Leu 
                245                 250                 255     


Val Ile Ala Ala Val Ile Lys Tyr Ala Asp Asn Ile Leu Lys Gly Phe 
            260                 265                 270         


Ala Thr Ser Leu Ser Ile Ile Leu Ser Thr Leu Ile Ser Tyr Phe Trp 
        275                 280                 285             


Leu Gln Asp Phe Val Pro Thr Ser Val Phe Phe Leu Gly Ala Ile Leu 
    290                 295                 300                 


Val Ile Thr Ala Thr Phe Leu Tyr Gly Tyr Asp Pro Lys Pro Ala Gly 
305                 310                 315                 320 


Asn Pro Thr Lys Ala 
                325 


<210>  1542
<211>  355
<212>  PRT
<213>  homo sapiens

<400>  1542

Met Ala Glu Val His Arg Arg Gln His Ala Arg Val Lys Gly Glu Ala 
1               5                   10                  15      


Pro Ala Lys Ser Ser Thr Leu Arg Asp Glu Glu Glu Leu Gly Met Ala 
            20                  25                  30          


Ser Ala Glu Thr Leu Thr Val Phe Leu Lys Leu Leu Ala Ala Gly Phe 
        35                  40                  45              


Tyr Gly Val Ser Ser Phe Leu Ile Val Val Val Asn Lys Ser Val Leu 
    50                  55                  60                  


Thr Asn Tyr Arg Phe Pro Ser Ser Leu Cys Val Gly Leu Gly Gln Met 
65                  70                  75                  80  


Val Ala Thr Val Ala Val Leu Trp Val Gly Lys Ala Leu Arg Val Val 
                85                  90                  95      


Lys Phe Pro Asp Leu Asp Arg Asn Val Pro Arg Lys Thr Phe Pro Leu 
            100                 105                 110         


Pro Leu Leu Tyr Phe Gly Asn Gln Ile Thr Gly Leu Phe Ser Thr Lys 
        115                 120                 125             


Lys Leu Asn Leu Pro Met Phe Thr Val Leu Arg Arg Phe Ser Ile Leu 
    130                 135                 140                 


Phe Thr Met Phe Ala Glu Gly Val Leu Leu Lys Lys Thr Phe Ser Trp 
145                 150                 155                 160 


Gly Ile Lys Met Thr Val Phe Ala Met Ile Ile Gly Ala Phe Val Ala 
                165                 170                 175     


Ala Ser Ser Asp Leu Ala Phe Asp Leu Glu Gly Tyr Ala Phe Ile Leu 
            180                 185                 190         


Ile Asn Asp Val Leu Thr Ala Ala Asn Gly Ala Tyr Val Lys Gln Lys 
        195                 200                 205             


Leu Asp Ser Lys Glu Leu Gly Lys Tyr Gly Leu Leu Tyr Tyr Asn Ala 
    210                 215                 220                 


Leu Phe Met Ile Leu Pro Thr Leu Ala Ile Ala Tyr Phe Thr Gly Asp 
225                 230                 235                 240 


Ala Gln Lys Ala Val Glu Phe Glu Gly Trp Ala Asp Thr Leu Phe Leu 
                245                 250                 255     


Leu Gln Phe Thr Leu Ser Cys Val Met Gly Phe Ile Leu Met Tyr Ala 
            260                 265                 270         


Thr Val Leu Cys Thr Gln Tyr Asn Ser Ala Leu Thr Thr Thr Ile Val 
        275                 280                 285             


Gly Cys Ile Lys Asn Ile Leu Ile Thr Tyr Ile Gly Met Val Phe Gly 
    290                 295                 300                 


Gly Asp Tyr Ile Phe Thr Trp Thr Asn Phe Ile Gly Leu Asn Ile Ser 
305                 310                 315                 320 


Ile Ala Gly Ser Leu Val Tyr Ser Tyr Ile Thr Phe Thr Glu Glu Gln 
                325                 330                 335     


Leu Ser Lys Gln Ser Glu Ala Asn Asn Lys Leu Asp Ile Lys Gly Lys 
            340                 345                 350         


Gly Ala Val 
        355 


<210>  1543
<211>  710
<212>  PRT
<213>  homo sapiens

<400>  1543

Met Gln Gly Lys Lys Pro Gly Gly Ser Ser Gly Gly Gly Arg Ser Gly 
1               5                   10                  15      


Glu Leu Gln Gly Asp Glu Ala Gln Arg Asn Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Val Ser Cys Phe Ser Asn Ile Lys Ile Phe Leu Val Ser Glu Cys Ala 
        35                  40                  45              


Leu Met Leu Ala Gln Gly Thr Val Gly Ala Tyr Leu Val Ser Val Leu 
    50                  55                  60                  


Thr Thr Leu Glu Arg Arg Phe Asn Leu Gln Ser Ala Asp Val Gly Val 
65                  70                  75                  80  


Ile Ala Ser Ser Phe Glu Ile Gly Asn Leu Ala Leu Ile Leu Phe Val 
                85                  90                  95      


Ser Tyr Phe Gly Ala Arg Gly His Arg Pro Arg Leu Ile Gly Cys Gly 
            100                 105                 110         


Gly Ile Val Met Ala Leu Gly Ala Leu Leu Ser Ala Leu Pro Glu Phe 
        115                 120                 125             


Leu Thr His Gln Tyr Lys Tyr Glu Ala Gly Glu Ile Arg Trp Gly Ala 
    130                 135                 140                 


Glu Gly Arg Asp Val Cys Ala Ala Asn Gly Ser Gly Gly Asp Glu Gly 
145                 150                 155                 160 


Pro Asp Pro Asp Leu Ile Cys Arg Asn Arg Thr Ala Thr Asn Met Met 
                165                 170                 175     


Tyr Leu Leu Leu Ile Gly Ala Gln Val Leu Leu Gly Ile Gly Ala Thr 
            180                 185                 190         


Pro Val Gln Pro Leu Gly Val Ser Tyr Ile Asp Asp His Val Arg Arg 
        195                 200                 205             


Lys Asp Ser Ser Leu Tyr Ile Gly Ile Leu Phe Thr Met Leu Val Phe 
    210                 215                 220                 


Gly Pro Ala Cys Gly Phe Ile Leu Gly Ser Phe Cys Thr Lys Ile Tyr 
225                 230                 235                 240 


Val Asp Ala Val Phe Ile Asp Thr Ser Asn Leu Asp Ile Thr Pro Asp 
                245                 250                 255     


Asp Pro Arg Trp Ile Gly Ala Trp Trp Gly Gly Phe Leu Leu Cys Gly 
            260                 265                 270         


Ala Leu Leu Phe Phe Ser Ser Leu Leu Met Phe Gly Phe Pro Gln Ser 
        275                 280                 285             


Leu Pro Pro His Ser Glu Pro Ala Met Glu Ser Glu Gln Ala Met Leu 
    290                 295                 300                 


Ser Glu Arg Glu Tyr Glu Arg Pro Lys Pro Ser Asn Gly Val Leu Arg 
305                 310                 315                 320 


His Pro Leu Glu Pro Asp Ser Ser Ala Ser Cys Phe Gln Gln Leu Arg 
                325                 330                 335     


Val Ile Pro Lys Val Thr Lys His Leu Leu Ser Asn Pro Val Phe Thr 
            340                 345                 350         


Cys Ile Ile Leu Ala Ala Cys Met Glu Ile Ala Val Val Ala Gly Phe 
        355                 360                 365             


Ala Ala Phe Leu Gly Lys Tyr Leu Glu Gln Gln Phe Asn Leu Thr Thr 
    370                 375                 380                 


Ser Ser Ala Asn Gln Leu Leu Gly Met Thr Ala Ile Pro Cys Ala Cys 
385                 390                 395                 400 


Leu Gly Ile Phe Leu Gly Gly Leu Leu Val Lys Lys Leu Ser Leu Ser 
                405                 410                 415     


Ala Leu Gly Ala Ile Arg Met Ala Met Leu Val Asn Leu Val Ser Thr 
            420                 425                 430         


Ala Cys Tyr Val Ser Phe Leu Phe Leu Gly Cys Asp Thr Gly Pro Val 
        435                 440                 445             


Ala Gly Val Thr Val Pro Tyr Gly Asn Ser Thr Ala Pro Gly Ser Ala 
    450                 455                 460                 


Leu Asp Pro Tyr Ser Pro Cys Asn Asn Asn Cys Glu Cys Gln Thr Asp 
465                 470                 475                 480 


Ser Phe Thr Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr Leu Ser Ala 
                485                 490                 495     


Cys Phe Ala Gly Cys Asn Ser Thr Asn Leu Thr Gly Cys Ala Cys Leu 
            500                 505                 510         


Thr Thr Val Pro Ala Glu Asn Ala Thr Val Val Pro Gly Lys Cys Pro 
        515                 520                 525             


Ser Pro Gly Cys Gln Glu Ala Phe Leu Thr Phe Leu Cys Val Met Cys 
    530                 535                 540                 


Ile Cys Ser Leu Ile Gly Ala Met Ala Gln Thr Pro Ser Val Ile Ile 
545                 550                 555                 560 


Leu Ile Arg Thr Val Ser Pro Glu Leu Lys Ser Tyr Ala Leu Gly Val 
                565                 570                 575     


Leu Phe Leu Leu Leu Arg Leu Leu Gly Phe Ile Pro Pro Pro Leu Ile 
            580                 585                 590         


Phe Gly Ala Gly Ile Asp Ser Thr Cys Leu Phe Trp Ser Thr Phe Cys 
        595                 600                 605             


Gly Glu Gln Gly Ala Cys Val Leu Tyr Asp Asn Val Val Tyr Arg Tyr 
    610                 615                 620                 


Leu Tyr Val Ser Ile Ala Ile Ala Leu Lys Ser Phe Ala Phe Ile Leu 
625                 630                 635                 640 


Tyr Thr Thr Thr Trp Gln Cys Leu Arg Lys Asn Tyr Lys Arg Tyr Ile 
                645                 650                 655     


Lys Asn His Glu Gly Gly Leu Ser Thr Ser Glu Phe Phe Ala Ser Thr 
            660                 665                 670         


Leu Thr Leu Asp Asn Leu Gly Arg Asp Pro Val Pro Ala Asn Gln Thr 
        675                 680                 685             


His Arg Thr Lys Phe Ile Tyr Asn Leu Glu Asp His Glu Trp Cys Glu 
    690                 695                 700                 


Asn Met Glu Ser Val Leu 
705                 710 


<210>  1544
<211>  1217
<212>  PRT
<213>  homo sapiens

<400>  1544

Met Tyr Ile Lys Gln Val Ile Ile Gln Gly Phe Arg Ser Tyr Arg Asp 
1               5                   10                  15      


Gln Thr Ile Val Asp Pro Phe Ser Ser Lys His Asn Val Ile Val Gly 
            20                  25                  30          


Arg Asn Gly Ser Gly Lys Ser Asn Phe Phe Tyr Ala Ile Gln Phe Val 
        35                  40                  45              


Leu Ser Asp Glu Phe Ser His Leu Arg Pro Glu Gln Arg Leu Ala Leu 
    50                  55                  60                  


Leu His Glu Gly Thr Gly Pro Arg Val Ile Ser Ala Phe Val Glu Ile 
65                  70                  75                  80  


Ile Phe Asp Asn Ser Asp Asn Arg Leu Pro Ile Asp Lys Glu Glu Val 
                85                  90                  95      


Ser Leu Arg Arg Val Ile Gly Ala Lys Lys Asp Gln Tyr Phe Leu Asp 
            100                 105                 110         


Lys Lys Met Val Thr Lys Asn Asp Val Met Asn Leu Leu Glu Ser Ala 
        115                 120                 125             


Gly Phe Ser Arg Ser Asn Pro Tyr Tyr Ile Val Lys Gln Gly Lys Ile 
    130                 135                 140                 


Asn Gln Met Ala Thr Ala Pro Asp Ser Gln Arg Leu Lys Leu Leu Arg 
145                 150                 155                 160 


Glu Val Ala Gly Thr Arg Val Tyr Asp Glu Arg Lys Glu Glu Ser Ile 
                165                 170                 175     


Ser Leu Met Lys Glu Thr Glu Gly Lys Arg Glu Lys Ile Asn Glu Leu 
            180                 185                 190         


Leu Lys Tyr Ile Glu Glu Arg Leu His Thr Leu Glu Glu Glu Lys Glu 
        195                 200                 205             


Glu Leu Ala Gln Tyr Gln Lys Trp Asp Lys Met Arg Arg Ala Leu Glu 
    210                 215                 220                 


Tyr Thr Ile Tyr Asn Gln Glu Leu Asn Glu Thr Arg Ala Lys Leu Asp 
225                 230                 235                 240 


Glu Leu Ser Ala Lys Arg Glu Thr Ser Gly Glu Lys Ser Arg Gln Leu 
                245                 250                 255     


Arg Asp Ala Gln Gln Asp Ala Arg Asp Lys Met Glu Asp Ile Glu Arg 
            260                 265                 270         


Gln Val Arg Glu Leu Lys Thr Lys Ile Ser Ala Met Lys Glu Glu Lys 
        275                 280                 285             


Glu Gln Leu Ser Ala Glu Arg Gln Glu Gln Ile Lys Gln Arg Thr Lys 
    290                 295                 300                 


Leu Glu Leu Lys Ala Lys Asp Leu Gln Asp Glu Leu Ala Gly Asn Ser 
305                 310                 315                 320 


Glu Gln Arg Lys Arg Leu Leu Lys Glu Arg Gln Lys Leu Leu Glu Lys 
                325                 330                 335     


Ile Glu Glu Lys Gln Lys Glu Leu Ala Glu Thr Glu Pro Lys Phe Asn 
            340                 345                 350         


Ser Val Lys Glu Lys Glu Glu Arg Gly Ile Ala Arg Leu Ala Gln Ala 
        355                 360                 365             


Thr Gln Glu Arg Thr Asp Leu Tyr Ala Lys Gln Gly Arg Gly Ser Gln 
    370                 375                 380                 


Phe Thr Ser Lys Glu Glu Arg Asp Lys Trp Ile Lys Lys Glu Leu Lys 
385                 390                 395                 400 


Ser Leu Asp Gln Ala Ile Asn Asp Lys Lys Arg Gln Ile Ala Ala Ile 
                405                 410                 415     


His Lys Asp Leu Glu Asp Thr Glu Ala Asn Lys Glu Lys Asn Leu Glu 
            420                 425                 430         


Gln Tyr Asn Lys Leu Asp Gln Asp Leu Asn Glu Val Lys Ala Arg Val 
        435                 440                 445             


Glu Glu Leu Asp Arg Lys Tyr Tyr Glu Val Lys Asn Lys Lys Asp Glu 
    450                 455                 460                 


Leu Gln Ser Glu Arg Asn Tyr Leu Trp Arg Glu Glu Asn Ala Glu Gln 
465                 470                 475                 480 


Gln Ala Leu Ala Ala Lys Arg Glu Asp Leu Glu Lys Lys Gln Gln Leu 
                485                 490                 495     


Leu Arg Ala Ala Thr Gly Lys Ala Ile Leu Asn Gly Ile Asp Ser Ile 
            500                 505                 510         


Asn Lys Val Leu Asp His Phe Arg Arg Lys Gly Ile Asn Gln His Val 
        515                 520                 525             


Gln Asn Gly Tyr His Gly Ile Val Met Asn Asn Phe Glu Cys Glu Pro 
    530                 535                 540                 


Ala Phe Tyr Thr Cys Val Glu Val Thr Ala Gly Asn Arg Leu Phe Tyr 
545                 550                 555                 560 


His Ile Val Asp Ser Asp Glu Val Ser Thr Lys Ile Leu Met Glu Phe 
                565                 570                 575     


Asn Lys Met Asn Leu Pro Gly Glu Val Thr Phe Leu Pro Leu Asn Lys 
            580                 585                 590         


Leu Asp Val Arg Asp Thr Ala Tyr Pro Glu Thr Asn Asp Ala Ile Pro 
        595                 600                 605             


Met Ile Ser Lys Leu Arg Tyr Asn Pro Arg Phe Asp Lys Ala Phe Lys 
    610                 615                 620                 


His Val Phe Gly Lys Thr Leu Ile Cys Arg Ser Met Glu Val Ser Thr 
625                 630                 635                 640 


Gln Leu Ala Arg Ala Phe Thr Met Asp Cys Ile Thr Leu Glu Gly Asp 
                645                 650                 655     


Gln Val Ser His Arg Gly Ala Leu Thr Gly Gly Tyr Tyr Asp Thr Arg 
            660                 665                 670         


Lys Ser Arg Leu Glu Leu Gln Lys Asp Val Arg Lys Ala Glu Glu Glu 
        675                 680                 685             


Leu Gly Glu Leu Glu Ala Lys Leu Asn Glu Asn Leu Arg Arg Asn Ile 
    690                 695                 700                 


Glu Arg Ile Asn Asn Glu Ile Asp Gln Leu Met Asn Gln Met Gln Gln 
705                 710                 715                 720 


Ile Glu Thr Gln Gln Arg Lys Phe Lys Ala Ser Arg Asp Ser Ile Leu 
                725                 730                 735     


Ser Glu Met Lys Met Leu Lys Glu Lys Arg Gln Gln Ser Glu Lys Thr 
            740                 745                 750         


Phe Met Pro Lys Gln Arg Ser Leu Gln Ser Leu Glu Ala Ser Leu His 
        755                 760                 765             


Ala Met Glu Ser Thr Arg Glu Ser Leu Lys Ala Glu Leu Gly Thr Asp 
    770                 775                 780                 


Leu Leu Ser Gln Leu Ser Leu Glu Asp Gln Lys Arg Val Asp Ala Leu 
785                 790                 795                 800 


Asn Asp Glu Ile Arg Gln Leu Gln Gln Glu Asn Arg Gln Leu Leu Asn 
                805                 810                 815     


Glu Arg Ile Lys Leu Glu Gly Ile Ile Thr Arg Val Glu Thr Tyr Leu 
            820                 825                 830         


Asn Glu Asn Leu Arg Lys Arg Leu Asp Gln Val Glu Gln Glu Leu Asn 
        835                 840                 845             


Glu Leu Arg Glu Thr Glu Gly Gly Thr Val Leu Thr Ala Thr Thr Ser 
    850                 855                 860                 


Glu Leu Glu Ala Ile Asn Lys Arg Val Lys Asp Thr Met Ala Arg Ser 
865                 870                 875                 880 


Glu Asp Leu Asp Asn Ser Ile Asp Lys Thr Glu Ala Gly Ile Lys Glu 
                885                 890                 895     


Leu Gln Lys Ser Met Glu Arg Trp Lys Asn Met Glu Lys Glu His Met 
            900                 905                 910         


Asp Ala Ile Asn His Asp Thr Lys Glu Leu Glu Lys Met Thr Asn Arg 
        915                 920                 925             


Gln Gly Met Leu Leu Lys Lys Lys Glu Glu Cys Met Lys Lys Ile Arg 
    930                 935                 940                 


Glu Leu Gly Ser Leu Pro Gln Glu Ala Phe Glu Lys Tyr Gln Thr Leu 
945                 950                 955                 960 


Ser Leu Lys Gln Leu Phe Arg Lys Leu Glu Gln Cys Asn Thr Glu Leu 
                965                 970                 975     


Lys Lys Tyr Ser His Val Asn Lys Lys Ala Leu Asp Gln Phe Val Asn 
            980                 985                 990         


Phe Ser Glu Gln Lys Glu Lys Leu  Ile Lys Arg Gln Glu  Glu Leu Asp 
        995                 1000                 1005             


Arg Gly  Tyr Lys Ser Ile Met  Glu Leu Met Asn Val  Leu Glu Leu 
    1010                 1015                 1020             


Arg Lys  Tyr Glu Ala Ile Gln  Leu Thr Phe Lys Gln  Val Ser Lys 
    1025                 1030                 1035             


Asn Phe  Ser Glu Val Phe Gln  Lys Leu Val Pro Gly  Gly Lys Ala 
    1040                 1045                 1050             


Thr Leu  Val Met Lys Lys Gly  Asp Val Glu Gly Ser  Gln Ser Gln 
    1055                 1060                 1065             


Asp Glu  Gly Glu Gly Ser Gly  Glu Ser Glu Arg Gly  Ser Gly Ser 
    1070                 1075                 1080             


Gln Ser  Ser Val Pro Ser Val  Asp Gln Phe Thr Gly  Val Gly Ile 
    1085                 1090                 1095             


Arg Val  Ser Phe Thr Gly Lys  Gln Gly Glu Met Arg  Glu Met Gln 
    1100                 1105                 1110             


Gln Leu  Ser Gly Gly Gln Lys  Ser Leu Val Ala Leu  Ala Leu Ile 
    1115                 1120                 1125             


Phe Ala  Ile Gln Lys Cys Asp  Pro Ala Pro Phe Tyr  Leu Phe Asp 
    1130                 1135                 1140             


Glu Ile  Asp Gln Ala Leu Asp  Ala Gln His Arg Lys  Ala Val Ser 
    1145                 1150                 1155             


Asp Met  Ile Met Glu Leu Ala  Val His Ala Gln Phe  Ile Thr Thr 
    1160                 1165                 1170             


Thr Phe  Arg Pro Glu Leu Leu  Glu Ser Ala Asp Lys  Phe Tyr Gly 
    1175                 1180                 1185             


Val Lys  Phe Arg Asn Lys Val  Ser His Ile Asp Val  Ile Thr Ala 
    1190                 1195                 1200             


Glu Met  Ala Lys Asp Phe Val  Glu Asp Asp Thr Thr  His Gly 
    1205                 1210                 1215         


<210>  1545
<211>  1091
<212>  PRT
<213>  homo sapiens

<400>  1545

Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys 
1               5                   10                  15      


Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu 
            20                  25                  30          


Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile 
        35                  40                  45              


Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro 
    50                  55                  60                  


Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg 
                85                  90                  95      


Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp 
            100                 105                 110         


Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp 
        115                 120                 125             


Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln 
    130                 135                 140                 


His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr 
145                 150                 155                 160 


Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp 
                165                 170                 175     


His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu 
            180                 185                 190         


Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys 
        195                 200                 205             


Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser 
    210                 215                 220                 


Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly 
225                 230                 235                 240 


Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu 
                245                 250                 255     


Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu 
            260                 265                 270         


Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys 
        275                 280                 285             


Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala 
    290                 295                 300                 


Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu 
305                 310                 315                 320 


Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser 
                325                 330                 335     


Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp 
            340                 345                 350         


Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn 
        355                 360                 365             


Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu 
    370                 375                 380                 


Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu 
385                 390                 395                 400 


Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg 
                405                 410                 415     


Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu 
            420                 425                 430         


Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile 
        435                 440                 445             


Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Arg 
    450                 455                 460                 


Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe 
465                 470                 475                 480 


Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg 
                485                 490                 495     


Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile 
            500                 505                 510         


His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys 
        515                 520                 525             


Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val 
    530                 535                 540                 


Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro 
545                 550                 555                 560 


Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His 
                565                 570                 575     


Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu 
            580                 585                 590         


Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile 
        595                 600                 605             


Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met 
    610                 615                 620                 


Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp 
625                 630                 635                 640 


Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg 
                645                 650                 655     


Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu 
            660                 665                 670         


Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His 
        675                 680                 685             


Leu Ser Ala Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys 
    690                 695                 700                 


Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn 
705                 710                 715                 720 


Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val 
                725                 730                 735     


Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met 
            740                 745                 750         


Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His 
        755                 760                 765             


Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys 
    770                 775                 780                 


Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu 
785                 790                 795                 800 


Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg 
                805                 810                 815     


His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys 
            820                 825                 830         


Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser 
        835                 840                 845             


Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala 
    850                 855                 860                 


Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala 
865                 870                 875                 880 


Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln 
                885                 890                 895     


Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu 
            900                 905                 910         


Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys 
        915                 920                 925             


Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr 
    930                 935                 940                 


Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe 
945                 950                 955                 960 


Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly 
                965                 970                 975     


Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg 
            980                 985                 990         


Ser Phe Ser Thr Val Cys Phe Ile  Leu Ser Leu Trp Ser  Ile Ala Glu 
        995                 1000                 1005             


Ser Pro  Phe Arg Cys Leu Asp  Glu Phe Asp Val Tyr  Met Asp Met 
    1010                 1015                 1020             


Val Asn  Arg Arg Ile Ala Met  Asp Leu Ile Leu Lys  Met Ala Asp 
    1025                 1030                 1035             


Ser Gln  Arg Phe Arg Gln Phe  Ile Leu Leu Thr Pro  Gln Ser Met 
    1040                 1045                 1050             


Ser Ser  Leu Pro Ser Ser Lys  Leu Ile Arg Ile Leu  Arg Met Ser 
    1055                 1060                 1065             


Asp Pro  Glu Arg Gly Gln Thr  Thr Leu Pro Phe Arg  Pro Val Thr 
    1070                 1075                 1080             


Gln Glu  Glu Asp Asp Asp Gln  Arg 
    1085                 1090     


<210>  1546
<211>  372
<212>  PRT
<213>  homo sapiens

<400>  1546

Met Ser Arg Arg Arg Phe Asp Cys Arg Ser Ile Ser Gly Leu Leu Thr 
1               5                   10                  15      


Thr Thr Pro Gln Ile Pro Ile Lys Met Glu Asn Phe Asn Asn Phe Tyr 
            20                  25                  30          


Ile Leu Thr Ser Lys Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg 
        35                  40                  45              


Gln Cys Ile Ser Lys Ser Thr Gly Gln Glu Tyr Ala Ala Lys Phe Leu 
    50                  55                  60                  


Lys Lys Arg Arg Arg Gly Gln Asp Cys Arg Ala Glu Ile Leu His Glu 
65                  70                  75                  80  


Ile Ala Val Leu Glu Leu Ala Lys Ser Cys Pro Arg Val Ile Asn Leu 
                85                  90                  95      


His Glu Val Tyr Glu Asn Thr Ser Glu Ile Ile Leu Ile Leu Glu Tyr 
            100                 105                 110         


Ala Ala Gly Gly Glu Ile Phe Ser Leu Cys Leu Pro Glu Leu Ala Glu 
        115                 120                 125             


Met Val Ser Glu Asn Asp Val Ile Arg Leu Ile Lys Gln Ile Leu Glu 
    130                 135                 140                 


Gly Val Tyr Tyr Leu His Gln Asn Asn Ile Val His Leu Asp Leu Lys 
145                 150                 155                 160 


Pro Gln Asn Ile Leu Leu Ser Ser Ile Tyr Pro Leu Gly Asp Ile Lys 
                165                 170                 175     


Ile Val Asp Phe Gly Met Ser Arg Lys Ile Gly His Ala Cys Glu Leu 
            180                 185                 190         


Arg Glu Ile Met Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Leu Asn 
        195                 200                 205             


Tyr Asp Pro Ile Thr Thr Ala Thr Asp Met Trp Asn Ile Gly Ile Ile 
    210                 215                 220                 


Ala Tyr Met Leu Leu Thr His Thr Ser Pro Phe Val Gly Glu Asp Asn 
225                 230                 235                 240 


Gln Glu Thr Tyr Leu Asn Ile Ser Gln Val Asn Val Asp Tyr Ser Glu 
                245                 250                 255     


Glu Thr Phe Ser Ser Val Ser Gln Leu Ala Thr Asp Phe Ile Gln Ser 
            260                 265                 270         


Leu Leu Val Lys Asn Pro Glu Lys Arg Pro Thr Ala Glu Ile Cys Leu 
        275                 280                 285             


Ser His Ser Trp Leu Gln Gln Trp Asp Phe Glu Asn Leu Phe His Pro 
    290                 295                 300                 


Glu Glu Thr Ser Ser Ser Ser Gln Thr Gln Asp His Ser Val Arg Ser 
305                 310                 315                 320 


Ser Glu Asp Lys Thr Ser Lys Ser Ser Cys Asn Gly Thr Cys Gly Asp 
                325                 330                 335     


Arg Glu Asp Lys Glu Asn Ile Pro Glu Asp Ser Ser Met Val Ser Lys 
            340                 345                 350         


Arg Phe Arg Phe Asp Asp Ser Leu Pro Asn Pro His Glu Leu Val Ser 
        355                 360                 365             


Asp Leu Leu Cys 
    370         


<210>  1547
<211>  414
<212>  PRT
<213>  homo sapiens

<400>  1547

Met Asn Leu Gln Arg Tyr Trp Gly Glu Ile Pro Ile Ser Ser Ser Gln 
1               5                   10                  15      


Thr Asn Arg Ser Ser Phe Asp Leu Leu Pro Arg Glu Phe Arg Leu Val 
            20                  25                  30          


Glu Val His Asp Pro Pro Leu His Gln Pro Ser Ala Asn Lys Pro Lys 
        35                  40                  45              


Pro Pro Thr Met Leu Asp Ile Pro Ser Glu Pro Cys Ser Leu Thr Ile 
    50                  55                  60                  


His Thr Ile Gln Leu Ile Gln His Asn Arg Arg Leu Arg Asn Leu Ile 
65                  70                  75                  80  


Ala Thr Ala Gln Ala Gln Asn Gln Gln Gln Thr Glu Gly Val Lys Thr 
                85                  90                  95      


Glu Glu Ser Glu Pro Leu Pro Ser Cys Pro Gly Ser Pro Pro Leu Pro 
            100                 105                 110         


Asp Asp Leu Leu Pro Leu Asp Cys Lys Asn Pro Asn Ala Pro Phe Gln 
        115                 120                 125             


Ile Arg His Ser Asp Pro Glu Ser Asp Phe Tyr Arg Gly Lys Gly Glu 
    130                 135                 140                 


Pro Val Thr Glu Leu Ser Trp His Ser Cys Arg Gln Leu Leu Tyr Gln 
145                 150                 155                 160 


Ala Val Ala Thr Ile Leu Ala His Ala Gly Phe Asp Cys Ala Asn Glu 
                165                 170                 175     


Ser Val Leu Glu Thr Leu Thr Asp Val Ala His Glu Tyr Cys Leu Lys 
            180                 185                 190         


Phe Thr Lys Leu Leu Arg Phe Ala Val Asp Arg Glu Ala Arg Leu Gly 
        195                 200                 205             


Gln Thr Pro Phe Pro Asp Val Met Glu Gln Val Phe His Glu Val Gly 
    210                 215                 220                 


Ile Gly Ser Val Leu Ser Leu Gln Lys Phe Trp Gln His Arg Ile Lys 
225                 230                 235                 240 


Asp Tyr His Ser Tyr Met Leu Gln Ile Ser Lys Gln Leu Ser Glu Glu 
                245                 250                 255     


Tyr Glu Arg Ile Val Asn Pro Glu Lys Ala Thr Glu Asp Ala Lys Pro 
            260                 265                 270         


Val Lys Ile Lys Glu Glu Pro Val Ser Asp Ile Thr Phe Pro Val Ser 
        275                 280                 285             


Glu Glu Leu Glu Ala Asp Leu Ala Ser Gly Asp Gln Ser Leu Pro Met 
    290                 295                 300                 


Gly Val Leu Gly Ala Gln Ser Glu Arg Phe Pro Ser Asn Leu Glu Val 
305                 310                 315                 320 


Glu Ala Ser Pro Gln Ala Ser Ser Ala Glu Val Asn Ala Ser Pro Leu 
                325                 330                 335     


Trp Asn Leu Ala His Val Lys Met Glu Pro Gln Glu Ser Glu Glu Gly 
            340                 345                 350         


Asn Val Ser Gly His Gly Val Leu Gly Ser Asp Val Phe Glu Glu Pro 
        355                 360                 365             


Met Ser Gly Met Ser Glu Ala Gly Ile Pro Gln Ser Pro Asp Asp Ser 
    370                 375                 380                 


Asp Ser Ser Tyr Gly Ser His Ser Thr Asp Ser Leu Met Gly Ser Ser 
385                 390                 395                 400 


Pro Val Phe Asn Gln Arg Cys Lys Lys Arg Met Arg Lys Ile 
                405                 410                 


<210>  1548
<211>  6885
<212>  PRT
<213>  homo sapiens

<400>  1548

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala 
        275                 280                 285             


Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly 
    290                 295                 300                 


Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser 
305                 310                 315                 320 


Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met 
                325                 330                 335     


Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile 
            340                 345                 350         


Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu 
        355                 360                 365             


Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu 
    370                 375                 380                 


Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln 
385                 390                 395                 400 


Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His 
                405                 410                 415     


Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser 
            420                 425                 430         


Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu 
        435                 440                 445             


Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu 
    450                 455                 460                 


Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu 
465                 470                 475                 480 


Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp 
                485                 490                 495     


Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg 
            500                 505                 510         


Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu 
        515                 520                 525             


Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu 
    530                 535                 540                 


Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr 
545                 550                 555                 560 


Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn 
                565                 570                 575     


Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val 
            580                 585                 590         


Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu 
        595                 600                 605             


Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu 
    610                 615                 620                 


His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn 
625                 630                 635                 640 


Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys 
                645                 650                 655     


Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro 
            660                 665                 670         


Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn 
        675                 680                 685             


Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met 
    690                 695                 700                 


Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu 
705                 710                 715                 720 


Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala 
                725                 730                 735     


Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu 
            740                 745                 750         


Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu 
        755                 760                 765             


Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met 
    770                 775                 780                 


Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser 
785                 790                 795                 800 


Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile 
                805                 810                 815     


Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala 
            820                 825                 830         


Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu 
        835                 840                 845             


Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala 
    850                 855                 860                 


Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys 
865                 870                 875                 880 


His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr 
                885                 890                 895     


Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys 
            900                 905                 910         


Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser 
        915                 920                 925             


Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile 
    930                 935                 940                 


Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile 
945                 950                 955                 960 


Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile 
                965                 970                 975     


Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu 
            980                 985                 990         


Asn His His Met Glu Val Leu Arg  Glu Leu Cys Glu Glu  Leu Pro Ser 
        995                 1000                 1005             


Gln Lys  Ser Gln Gln Glu Val  Lys Arg Leu Leu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Arg Leu Leu  Lys Cys Ala Ser Glu  Ile His Met 
    1025                 1030                 1035             


Thr Leu  Gln Pro Thr Ala Gly  Gly Thr Ser Lys Asn  Glu Gly Thr 
    1040                 1045                 1050             


Ile Thr  Thr Ser Glu Asn Arg  Gly Gly Asp Pro His  Ser Glu Ala 
    1055                 1060                 1065             


Pro Phe  Ala Lys Ser Asp Asn  Gln Pro Ser Thr Glu  Lys Ala Met 
    1070                 1075                 1080             


Glu Pro  Thr Met Lys Phe Ser  Leu Ala Ser Val Leu  Arg Pro Leu 
    1085                 1090                 1095             


Gln Glu  Glu Ser Ile Met Glu  Lys Asp Tyr Ser Ala  Ser Ile Asn 
    1100                 1105                 1110             


Ser Leu  Leu Glu Arg Tyr Asp  Thr Tyr Arg Asp Ile  Leu Glu His 
    1115                 1120                 1125             


His Leu  Gln Asn Asn Lys Phe  Arg Ile Thr Ser Asp  Phe Ser Ser 
    1130                 1135                 1140             


Glu Glu  Asp Arg Ser Ser Ser  Cys Leu Gln Ala Lys  Leu Thr Asp 
    1145                 1150                 1155             


Leu Gln  Val Ile Lys Asn Glu  Thr Asp Ala Arg Trp  Lys Glu Phe 
    1160                 1165                 1170             


Glu Ile  Ile Ser Leu Lys Leu  Glu Asn His Val Asn  Asp Ile Lys 
    1175                 1180                 1185             


Lys Pro  Phe Val Ile Lys Glu  Arg Asp Thr Leu Lys  Glu Arg Glu 
    1190                 1195                 1200             


Arg Glu  Leu Gln Met Thr Leu  Asn Thr Arg Met Glu  Ser Leu Glu 
    1205                 1210                 1215             


Thr Ala  Leu Arg Leu Val Leu  Pro Val Glu Lys Ala  Ser Leu Leu 
    1220                 1225                 1230             


Leu Cys  Gly Ser Asp Leu Pro  Leu His Lys Met Ala  Ile Gln Gly 
    1235                 1240                 1245             


Phe His  Leu Ile Asp Ala Asp  Arg Ile Tyr Gln His  Leu Arg Asn 
    1250                 1255                 1260             


Ile Gln  Asp Ser Ile Ala Lys  Gln Ile Glu Ile Cys  Asn Arg Leu 
    1265                 1270                 1275             


Glu Glu  Pro Gly Asn Phe Val  Leu Lys Glu Leu His  Pro Phe Asp 
    1280                 1285                 1290             


Leu His  Ala Met Gln Asn Ile  Ile Leu Lys Tyr Lys  Thr Gln Phe 
    1295                 1300                 1305             


Glu Gly  Met Asn His Arg Val  Gln Arg Ser Glu Asp  Thr Leu Lys 
    1310                 1315                 1320             


Ala Leu  Glu Asp Phe Leu Ala  Ser Leu Arg Thr Ala  Lys Leu Ser 
    1325                 1330                 1335             


Ala Glu  Pro Val Thr Asp Leu  Ser Ala Ser Asp Thr  Gln Val Ala 
    1340                 1345                 1350             


Gln Glu  Asn Thr Leu Thr Val  Lys Asn Lys Glu Gly  Glu Ile His 
    1355                 1360                 1365             


Leu Met  Lys Asp Lys Ala Lys  His Leu Asp Lys Cys  Leu Lys Met 
    1370                 1375                 1380             


Leu Asp  Met Ser Phe Lys Asp  Ala Glu Arg Gly Asp  Asp Thr Ser 
    1385                 1390                 1395             


Cys Glu  Asn Leu Leu Asp Ala  Phe Ser Ile Lys Leu  Ser Glu Thr 
    1400                 1405                 1410             


His Gly  Tyr Gly Val Gln Glu  Glu Phe Thr Glu Glu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Glu  Ala Cys Ile Phe Lys  Asn Asn Glu Leu Leu  Lys Asn Ile 
    1430                 1435                 1440             


Gln Asp  Val Gln Ser Gln Ile  Ser Lys Ile Gly Leu  Lys Asp Pro 
    1445                 1450                 1455             


Thr Val  Pro Ala Val Lys His  Arg Lys Lys Ser Leu  Ile Arg Leu 
    1460                 1465                 1470             


Asp Lys  Val Leu Asp Glu Tyr  Glu Glu Glu Lys Arg  His Leu Gln 
    1475                 1480                 1485             


Glu Met  Ala Asn Ser Leu Pro  His Phe Lys Asp Gly  Arg Glu Lys 
    1490                 1495                 1500             


Thr Val  Asn Gln Gln Cys Gln  Asn Thr Val Val Leu  Trp Glu Asn 
    1505                 1510                 1515             


Thr Lys  Ala Leu Val Thr Glu  Cys Leu Glu Gln Cys  Gly Arg Val 
    1520                 1525                 1530             


Leu Glu  Leu Leu Lys Gln Tyr  Gln Asn Phe Lys Ser  Ile Leu Thr 
    1535                 1540                 1545             


Thr Leu  Ile Gln Lys Glu Glu  Ser Val Ile Ser Leu  Gln Ala Ser 
    1550                 1555                 1560             


Tyr Met  Gly Lys Glu Asn Leu  Lys Lys Arg Ile Ala  Glu Ile Glu 
    1565                 1570                 1575             


Ile Val  Lys Glu Glu Phe Asn  Glu His Leu Glu Val  Val Asp Lys 
    1580                 1585                 1590             


Ile Asn  Gln Val Cys Lys Asn  Leu Gln Phe Tyr Leu  Asn Lys Met 
    1595                 1600                 1605             


Lys Thr  Phe Glu Glu Pro Pro  Phe Glu Lys Glu Ala  Asn Ile Ile 
    1610                 1615                 1620             


Val Asp  Arg Trp Leu Asp Ile  Asn Glu Lys Thr Glu  Asp Tyr Tyr 
    1625                 1630                 1635             


Glu Asn  Leu Gly Arg Ala Leu  Ala Leu Trp Asp Lys  Leu Phe Asn 
    1640                 1645                 1650             


Leu Lys  Asn Val Ile Asp Glu  Trp Thr Glu Lys Ala  Leu Gln Lys 
    1655                 1660                 1665             


Met Glu  Leu His Gln Leu Thr  Glu Glu Asp Arg Glu  Arg Leu Lys 
    1670                 1675                 1680             


Glu Glu  Leu Gln Val His Glu  Gln Lys Thr Ser Glu  Phe Ser Arg 
    1685                 1690                 1695             


Arg Val  Ala Glu Ile Gln Phe  Leu Leu Gln Ser Ser  Glu Ile Pro 
    1700                 1705                 1710             


Leu Glu  Leu Gln Val Met Glu  Ser Ser Ile Leu Asn  Lys Met Glu 
    1715                 1720                 1725             


His Val  Gln Lys Cys Leu Thr  Gly Glu Ser Asn Cys  His Ala Leu 
    1730                 1735                 1740             


Ser Gly  Ser Thr Ala Glu Leu  Arg Glu Asp Leu Asp  Gln Ala Lys 
    1745                 1750                 1755             


Thr Gln  Ile Gly Met Thr Glu  Ser Leu Leu Lys Ala  Leu Ser Pro 
    1760                 1765                 1770             


Ser Asp  Ser Leu Glu Ile Phe  Thr Lys Leu Glu Glu  Ile Gln Gln 
    1775                 1780                 1785             


Gln Ile  Leu Gln Gln Lys His  Ser Met Ile Leu Leu  Glu Asn Gln 
    1790                 1795                 1800             


Ile Gly  Cys Leu Thr Pro Glu  Leu Ser Glu Leu Lys  Lys Gln Tyr 
    1805                 1810                 1815             


Glu Ser  Val Ser Asp Leu Phe  Asn Thr Lys Lys Ser  Val Leu Gln 
    1820                 1825                 1830             


Asp His  Phe Ser Lys Leu Leu  Asn Asp Gln Cys Lys  Asn Phe Asn 
    1835                 1840                 1845             


Asp Trp  Phe Ser Asn Ile Lys  Val Asn Leu Lys Glu  Cys Phe Glu 
    1850                 1855                 1860             


Ser Ser  Glu Thr Lys Lys Ser  Val Glu Gln Lys Leu  Gln Lys Leu 
    1865                 1870                 1875             


Ser Asp  Phe Leu Thr Leu Glu  Gly Arg Asn Ser Lys  Ile Lys Gln 
    1880                 1885                 1890             


Val Asp  Ser Val Leu Lys His  Val Lys Lys His Leu  Pro Lys Ala 
    1895                 1900                 1905             


His Val  Lys Glu Leu Ile Ser  Trp Leu Val Gly Gln  Glu Phe Glu 
    1910                 1915                 1920             


Leu Glu  Lys Met Glu Ser Ile  Cys Gln Ala Arg Ala  Lys Glu Leu 
    1925                 1930                 1935             


Glu Asp  Ser Leu Gln Gln Leu  Leu Arg Leu Gln Asp  Asp His Arg 
    1940                 1945                 1950             


Asn Leu  Arg Lys Trp Leu Thr  Asn Gln Glu Glu Lys  Trp Lys Gly 
    1955                 1960                 1965             


Met Glu  Glu Pro Gly Glu Lys  Thr Glu Leu Phe Cys  Gln Ala Leu 
    1970                 1975                 1980             


Ala Arg  Lys Arg Glu Gln Phe  Glu Ser Val Ala Gln  Leu Asn Asn 
    1985                 1990                 1995             


Ser Leu  Lys Glu Tyr Gly Phe  Thr Glu Glu Glu Glu  Ile Ile Met 
    2000                 2005                 2010             


Glu Ala  Thr Cys Leu Met Asp  Arg Tyr Gln Thr Leu  Leu Arg Gln 
    2015                 2020                 2025             


Leu Ser  Glu Ile Glu Glu Glu  Asp Lys Leu Leu Pro  Thr Glu Asp 
    2030                 2035                 2040             


Gln Ser  Phe Asn Asp Leu Ala  His Asp Val Ile His  Trp Ile Lys 
    2045                 2050                 2055             


Glu Ile  Lys Glu Ser Leu Met  Val Leu Asn Ser Ser  Glu Gly Lys 
    2060                 2065                 2070             


Met Pro  Leu Glu Glu Arg Ile  Gln Lys Ile Lys Glu  Ile Ile Leu 
    2075                 2080                 2085             


Leu Lys  Pro Glu Gly Asp Ala  Arg Ile Glu Thr Ile  Met Lys Gln 
    2090                 2095                 2100             


Ala Glu  Ser Ser Glu Ala Pro  Leu Val Gln Lys Thr  Leu Thr Asp 
    2105                 2110                 2115             


Ile Ser  Asn Gln Trp Asp Asn  Thr Leu His Leu Ala  Ser Thr Tyr 
    2120                 2125                 2130             


Leu Ser  His Gln Glu Lys Leu  Leu Leu Glu Gly Glu  Lys Tyr Leu 
    2135                 2140                 2145             


Gln Ser  Lys Glu Asp Leu Arg  Leu Met Leu Ile Glu  Leu Lys Lys 
    2150                 2155                 2160             


Lys Gln  Glu Ala Gly Phe Ala  Leu Gln His Gly Leu  Gln Glu Lys 
    2165                 2170                 2175             


Lys Ala  Gln Leu Lys Ile Tyr  Lys Lys Phe Leu Lys  Lys Ala Gln 
    2180                 2185                 2190             


Asp Leu  Thr Ser Leu Leu Lys  Glu Leu Lys Ser Gln  Gly Asn Tyr 
    2195                 2200                 2205             


Leu Leu  Glu Cys Thr Lys Asn  Pro Ser Phe Ser Glu  Glu Pro Trp 
    2210                 2215                 2220             


Leu Glu  Ile Lys His Leu His  Glu Ser Leu Leu Gln  Gln Leu Gln 
    2225                 2230                 2235             


Asp Ser  Val Gln Asn Leu Asp  Gly His Val Arg Glu  His Asp Ser 
    2240                 2245                 2250             


Tyr Gln  Val Cys Val Thr Asp  Leu Asn Thr Thr Leu  Asp Asn Phe 
    2255                 2260                 2265             


Ser Lys  Glu Phe Val Ser Phe  Ser Asp Lys Pro Val  Asp Gln Ile 
    2270                 2275                 2280             


Ala Val  Glu Glu Lys Leu Gln  Lys Leu Gln Glu Leu  Glu Asn Arg 
    2285                 2290                 2295             


Leu Ser  Leu Gln Asp Gly Thr  Leu Lys Lys Ile Leu  Ala Leu Ala 
    2300                 2305                 2310             


Lys Ser  Val Lys Gln Asn Thr  Ser Ser Val Gly Gln  Lys Ile Ile 
    2315                 2320                 2325             


Lys Asp  Asp Ile Lys Ser Leu  Gln Cys Lys Gln Lys  Asp Leu Glu 
    2330                 2335                 2340             


Asn Arg  Leu Ala Ser Ala Lys  Gln Glu Met Glu Cys  Cys Leu Asn 
    2345                 2350                 2355             


Ser Ile  Leu Lys Ser Lys Arg  Ser Thr Glu Lys Lys  Gly Lys Phe 
    2360                 2365                 2370             


Thr Leu  Pro Gly Arg Glu Lys  Gln Ala Thr Ser Asp  Val Gln Glu 
    2375                 2380                 2385             


Ser Thr  Gln Glu Ser Ala Ala  Val Glu Lys Leu Glu  Glu Asp Trp 
    2390                 2395                 2400             


Glu Ile  Asn Lys Asp Ser Ala  Val Glu Met Ala Met  Ser Lys Gln 
    2405                 2410                 2415             


Leu Ser  Leu Asn Ala Gln Glu  Ser Met Lys Asn Thr  Glu Asp Glu 
    2420                 2425                 2430             


Arg Lys  Val Asn Glu Leu Gln  Asn Gln Pro Leu Glu  Leu Asp Thr 
    2435                 2440                 2445             


Met Leu  Arg Asn Glu Gln Leu  Glu Glu Ile Glu Lys  Leu Tyr Thr 
    2450                 2455                 2460             


Gln Leu  Glu Ala Lys Lys Ala  Ala Ile Lys Pro Leu  Glu Gln Thr 
    2465                 2470                 2475             


Glu Cys  Leu Asn Lys Thr Glu  Thr Gly Ala Leu Val  Leu His Asn 
    2480                 2485                 2490             


Ile Gly  Tyr Ser Ala Gln His  Leu Asp Asn Leu Leu  Gln Ala Leu 
    2495                 2500                 2505             


Ile Thr  Leu Lys Lys Asn Lys  Glu Ser Gln Tyr Cys  Val Leu Arg 
    2510                 2515                 2520             


Asp Phe  Gln Glu Tyr Leu Ala  Ala Val Glu Ser Ser  Met Lys Ala 
    2525                 2530                 2535             


Leu Leu  Thr Asp Lys Glu Ser  Leu Lys Val Gly Pro  Leu Asp Ser 
    2540                 2545                 2550             


Val Thr  Tyr Leu Asp Lys Ile  Lys Lys Phe Ile Ala  Ser Ile Glu 
    2555                 2560                 2565             


Lys Glu  Lys Asp Ser Leu Gly  Asn Leu Lys Ile Lys  Trp Glu Asn 
    2570                 2575                 2580             


Leu Ser  Asn His Val Thr Asp  Met Asp Lys Lys Leu  Leu Glu Ser 
    2585                 2590                 2595             


Gln Ile  Lys Gln Leu Glu His  Gly Trp Glu Gln Val  Glu Gln Gln 
    2600                 2605                 2610             


Ile Gln  Lys Lys Tyr Ser Gln  Gln Val Val Glu Tyr  Asp Glu Phe 
    2615                 2620                 2625             


Thr Thr  Leu Met Asn Lys Val  Gln Asp Thr Glu Ile  Ser Leu Gln 
    2630                 2635                 2640             


Gln Gln  Gln Gln His Leu Gln  Leu Arg Leu Lys Ser  Pro Glu Glu 
    2645                 2650                 2655             


Arg Ala  Gly Asn Gln Ser Met  Ile Ala Leu Thr Thr  Asp Leu Gln 
    2660                 2665                 2670             


Ala Thr  Lys His Gly Phe Ser  Val Leu Lys Gly Gln  Ala Glu Leu 
    2675                 2680                 2685             


Gln Met  Lys Arg Ile Trp Gly  Glu Lys Glu Lys Lys  Asn Leu Glu 
    2690                 2695                 2700             


Asp Gly  Ile Asn Asn Leu Lys  Lys Gln Trp Glu Thr  Leu Glu Pro 
    2705                 2710                 2715             


Leu His  Leu Glu Ala Glu Asn  Gln Ile Lys Lys Cys  Asp Ile Arg 
    2720                 2725                 2730             


Asn Lys  Met Lys Glu Thr Ile  Leu Trp Ala Lys Asn  Leu Leu Gly 
    2735                 2740                 2745             


Glu Leu  Asn Pro Ser Ile Pro  Leu Leu Pro Asp Asp  Ile Leu Ser 
    2750                 2755                 2760             


Gln Ile  Arg Lys Cys Lys Val  Thr His Asp Gly Ile  Leu Ala Arg 
    2765                 2770                 2775             


Gln Gln  Ser Val Glu Ser Leu  Ala Glu Glu Val Lys  Asp Lys Val 
    2780                 2785                 2790             


Pro Ser  Leu Thr Thr Tyr Glu  Gly Ser Asp Leu Asn  Asn Thr Leu 
    2795                 2800                 2805             


Glu Asp  Leu Arg Asn Gln Tyr  Gln Met Leu Val Leu  Lys Ser Thr 
    2810                 2815                 2820             


Gln Arg  Ser Gln Gln Leu Glu  Phe Lys Leu Glu Glu  Arg Ser Asn 
    2825                 2830                 2835             


Phe Phe  Ala Ile Ile Arg Lys  Phe Gln Leu Met Val  Gln Glu Ser 
    2840                 2845                 2850             


Glu Thr  Leu Ile Ile Pro Arg  Val Glu Thr Ala Ala  Thr Glu Ala 
    2855                 2860                 2865             


Glu Leu  Lys His His His Val  Thr Leu Glu Ala Ser  Gln Lys Glu 
    2870                 2875                 2880             


Leu Gln  Glu Ile Asp Ser Gly  Ile Ser Thr His Leu  Gln Glu Leu 
    2885                 2890                 2895             


Thr Asn  Ile Tyr Glu Glu Leu  Asn Val Phe Glu Arg  Leu Phe Leu 
    2900                 2905                 2910             


Glu Asp  Gln Leu Lys Asn Leu  Lys Ile Arg Thr Asn  Arg Ile Gln 
    2915                 2920                 2925             


Arg Phe  Ile Gln Asn Thr Cys  Asn Glu Val Glu His  Lys Ile Lys 
    2930                 2935                 2940             


Phe Cys  Arg Gln Phe His Glu  Lys Thr Ser Ala Leu  Gln Glu Glu 
    2945                 2950                 2955             


Ala Asp  Ser Ile Gln Arg Asn  Glu Leu Leu Leu Asn  Gln Glu Val 
    2960                 2965                 2970             


Asn Lys  Gly Val Lys Glu Glu  Ile Tyr Asn Leu Lys  Asp Arg Leu 
    2975                 2980                 2985             


Thr Ala  Ile Lys Cys Cys Ile  Leu Gln Val Leu Lys  Leu Lys Lys 
    2990                 2995                 3000             


Val Phe  Asp Tyr Ile Gly Leu  Asn Trp Asp Phe Ser  Gln Leu Asp 
    3005                 3010                 3015             


Gln Leu  Gln Thr Gln Val Phe  Glu Lys Glu Lys Glu  Leu Glu Glu 
    3020                 3025                 3030             


Lys Ile  Lys Gln Leu Asp Thr  Phe Glu Glu Glu His  Gly Lys Tyr 
    3035                 3040                 3045             


Gln Ala  Leu Leu Ser Lys Met  Arg Ala Ile Asp Leu  Gln Ile Lys 
    3050                 3055                 3060             


Lys Met  Thr Glu Val Val Leu  Lys Ala Pro Asp Ser  Ser Pro Glu 
    3065                 3070                 3075             


Ser Arg  Arg Leu Asn Ala Gln  Ile Leu Ser Gln Arg  Ile Glu Lys 
    3080                 3085                 3090             


Ala Lys  Cys Leu Cys Asp Glu  Ile Ile Lys Lys Leu  Asn Glu Asn 
    3095                 3100                 3105             


Lys Thr  Phe Asp Asp Ser Phe  Lys Glu Lys Glu Ile  Leu Gln Ile 
    3110                 3115                 3120             


Lys Leu  Asn Ala Glu Glu Asn  Asp Lys Leu Tyr Lys  Val Leu Gln 
    3125                 3130                 3135             


Asn Met  Val Leu Glu Leu Ser  Pro Lys Glu Leu Asp  Glu Lys Asn 
    3140                 3145                 3150             


Cys Gln  Asp Lys Leu Glu Thr  Ser Leu His Val Leu  Asn Gln Ile 
    3155                 3160                 3165             


Lys Ser  Gln Leu Gln Gln Pro  Leu Leu Ile Asn Leu  Glu Ile Lys 
    3170                 3175                 3180             


His Ile  Gln Asn Glu Lys Asp  Asn Cys Glu Ala Phe  Gln Glu Gln 
    3185                 3190                 3195             


Val Trp  Ala Glu Met Cys Ser  Ile Lys Ala Val Thr  Ala Ile Glu 
    3200                 3205                 3210             


Lys Gln  Arg Glu Glu Asn Ser  Ser Glu Ala Ser Asp  Val Glu Thr 
    3215                 3220                 3225             


Lys Leu  Arg Glu Phe Glu Asp  Leu Gln Met Gln Leu  Asn Thr Ser 
    3230                 3235                 3240             


Ile Asp  Leu Arg Thr Asn Val  Leu Asn Asp Ala Tyr  Glu Asn Leu 
    3245                 3250                 3255             


Thr Arg  Tyr Lys Glu Ala Val  Thr Arg Ala Val Glu  Ser Ile Thr 
    3260                 3265                 3270             


Ser Leu  Glu Ala Ile Ile Ile  Pro Tyr Arg Val Asp  Val Gly Asn 
    3275                 3280                 3285             


Pro Glu  Glu Ser Leu Glu Met  Pro Leu Arg Lys Gln  Glu Glu Leu 
    3290                 3295                 3300             


Glu Ser  Thr Val Ala His Ile  Gln Asp Leu Thr Glu  Lys Leu Gly 
    3305                 3310                 3315             


Met Ile  Ser Ser Pro Glu Ala  Lys Leu Gln Leu Gln  Tyr Thr Leu 
    3320                 3325                 3330             


Gln Glu  Leu Val Ser Lys Asn  Ser Ala Met Lys Glu  Ala Phe Lys 
    3335                 3340                 3345             


Ala Gln  Glu Thr Glu Ala Glu  Arg Tyr Leu Glu Asn  Tyr Lys Cys 
    3350                 3355                 3360             


Tyr Arg  Lys Met Glu Glu Asp  Ile Tyr Thr Asn Leu  Ser Lys Met 
    3365                 3370                 3375             


Glu Thr  Val Leu Gly Gln Ser  Met Ser Ser Leu Pro  Leu Ser Tyr 
    3380                 3385                 3390             


Arg Glu  Ala Leu Glu Arg Leu  Glu Gln Ser Lys Ala  Leu Val Ser 
    3395                 3400                 3405             


Asn Leu  Ile Ser Thr Lys Glu  Glu Leu Met Lys Leu  Arg Gln Ile 
    3410                 3415                 3420             


Leu Arg  Leu Leu Arg Leu Arg  Cys Thr Glu Asn Asp  Gly Ile Cys 
    3425                 3430                 3435             


Leu Leu  Lys Ile Val Ser Ala  Leu Trp Glu Lys Trp  Leu Ser Leu 
    3440                 3445                 3450             


Leu Glu  Ala Ala Lys Glu Trp  Glu Met Trp Cys Glu  Glu Leu Lys 
    3455                 3460                 3465             


Gln Glu  Trp Lys Phe Val Ser  Glu Glu Ile Glu Arg  Glu Ala Ile 
    3470                 3475                 3480             


Ile Leu  Asp Asn Leu Gln Glu  Glu Leu Pro Glu Ile  Ser Lys Thr 
    3485                 3490                 3495             


Lys Glu  Ala Ala Thr Thr Glu  Glu Leu Ser Glu Leu  Leu Asp Cys 
    3500                 3505                 3510             


Leu Cys  Gln Tyr Gly Glu Asn  Val Glu Lys Gln Gln  Leu Leu Leu 
    3515                 3520                 3525             


Thr Leu  Leu Leu Gln Arg Ile  Arg Ser Ile Gln Asn  Val Pro Glu 
    3530                 3535                 3540             


Ser Ser  Gly Ala Val Glu Thr  Val Pro Ala Phe Gln  Glu Ile Thr 
    3545                 3550                 3555             


Ser Met  Lys Glu Arg Cys Asn  Lys Leu Leu Gln Lys  Val Gln Lys 
    3560                 3565                 3570             


Asn Lys  Glu Leu Val Gln Thr  Glu Ile Gln Glu Arg  His Ser Phe 
    3575                 3580                 3585             


Thr Lys  Glu Ile Ile Ala Leu  Lys Asn Phe Phe Gln  Gln Thr Thr 
    3590                 3595                 3600             


Thr Ser  Phe Gln Asn Met Ala  Phe Gln Asp His Pro  Glu Lys Ser 
    3605                 3610                 3615             


Glu Gln  Phe Glu Glu Leu Gln  Ser Ile Leu Lys Lys  Gly Lys Leu 
    3620                 3625                 3630             


Thr Phe  Glu Asn Ile Met Glu  Lys Leu Arg Ile Lys  Tyr Ser Glu 
    3635                 3640                 3645             


Met Tyr  Thr Ile Val Pro Ala  Glu Ile Glu Ser Gln  Val Glu Glu 
    3650                 3655                 3660             


Cys Arg  Lys Ala Leu Glu Asp  Ile Asp Glu Lys Ile  Ser Asn Glu 
    3665                 3670                 3675             


Val Leu  Lys Ser Ser Pro Ser  Tyr Ala Met Arg Arg  Lys Ile Glu 
    3680                 3685                 3690             


Glu Ile  Asn Asn Gly Leu His  Asn Val Glu Lys Met  Leu Gln Gln 
    3695                 3700                 3705             


Lys Ser  Lys Asn Ile Glu Lys  Ala Gln Glu Ile Gln  Lys Lys Met 
    3710                 3715                 3720             


Trp Asp  Glu Leu Asp Leu Trp  His Ser Lys Leu Asn  Glu Leu Asp 
    3725                 3730                 3735             


Ser Glu  Val Gln Asp Ile Val  Glu Gln Asp Pro Gly  Gln Ala Gln 
    3740                 3745                 3750             


Glu Trp  Met Asp Asn Leu Met  Ile Pro Phe Gln Gln  Tyr Gln Gln 
    3755                 3760                 3765             


Val Ser  Gln Arg Ala Glu Cys  Arg Thr Ser Gln Leu  Asn Lys Ala 
    3770                 3775                 3780             


Thr Val  Lys Met Glu Glu Tyr  Ser Asp Leu Leu Lys  Ser Thr Glu 
    3785                 3790                 3795             


Ala Trp  Ile Glu Asn Thr Ser  His Leu Leu Ala Asn  Pro Ala Asp 
    3800                 3805                 3810             


Tyr Asp  Ser Leu Arg Thr Leu  Ser His His Ala Ser  Thr Val Gln 
    3815                 3820                 3825             


Met Ala  Leu Glu Asp Ser Glu  Gln Lys His Asn Leu  Leu His Ser 
    3830                 3835                 3840             


Ile Phe  Met Asp Leu Glu Asp  Leu Ser Ile Ile Phe  Glu Thr Asp 
    3845                 3850                 3855             


Glu Leu  Thr Gln Ser Ile Gln  Glu Leu Ser Asn Gln  Val Thr Ala 
    3860                 3865                 3870             


Leu Gln  Gln Lys Ile Met Glu  Ser Leu Pro Gln Ile  Gln Arg Met 
    3875                 3880                 3885             


Ala Asp  Asp Val Val Ala Ile  Glu Ser Glu Val Lys  Ser Met Glu 
    3890                 3895                 3900             


Lys Arg  Val Ser Lys Ile Lys  Thr Ile Leu Leu Ser  Lys Glu Ile 
    3905                 3910                 3915             


Phe Asp  Phe Ser Pro Glu Glu  His Leu Lys His Gly  Glu Val Ile 
    3920                 3925                 3930             


Leu Glu  Asn Ile Arg Pro Met  Lys Lys Thr Ile Ala  Glu Ile Val 
    3935                 3940                 3945             


Ser Tyr  Gln Val Glu Leu Arg  Leu Pro Gln Thr Gly  Met Lys Pro 
    3950                 3955                 3960             


Leu Pro  Val Phe Gln Arg Thr  Asn Gln Leu Leu Gln  Asp Ile Lys 
    3965                 3970                 3975             


Leu Leu  Glu Asn Val Thr Gln  Glu Gln Asn Glu Leu  Leu Lys Val 
    3980                 3985                 3990             


Val Ile  Lys Gln Thr Asn Glu  Trp Asp Glu Glu Ile  Glu Asn Leu 
    3995                 4000                 4005             


Lys Gln  Ile Leu Asn Asn Tyr  Ser Ala Gln Phe Ser  Leu Glu His 
    4010                 4015                 4020             


Met Ser  Pro Asp Gln Ala Asp  Lys Leu Pro Gln Leu  Gln Gly Glu 
    4025                 4030                 4035             


Ile Glu  Arg Met Glu Lys Gln  Ile Leu Ser Leu Asn  Gln Arg Lys 
    4040                 4045                 4050             


Glu Asp  Leu Leu Val Asp Leu  Lys Ala Thr Val Leu  Asn Leu His 
    4055                 4060                 4065             


Gln His  Leu Lys Gln Glu Gln  Glu Gly Val Glu Arg  Asp Arg Leu 
    4070                 4075                 4080             


Pro Ala  Val Thr Ser Glu Glu  Gly Gly Val Ala Glu  Arg Asp Ala 
    4085                 4090                 4095             


Ser Glu  Arg Lys Leu Asn Arg  Arg Gly Ser Met Ser  Tyr Leu Ala 
    4100                 4105                 4110             


Ala Val  Glu Glu Glu Val Glu  Glu Ser Ser Val Lys  Ser Asp Asn 
    4115                 4120                 4125             


Gly Asp  Glu Lys Ala Glu Pro  Ser Pro Gln Ser Trp  Ser Ser Leu 
    4130                 4135                 4140             


Trp Lys  His Asp Lys Asp Met  Glu Glu Asp Arg Ala  Ser Ser Ser 
    4145                 4150                 4155             


Ser Gly  Thr Ile Val Gln Glu  Ala Tyr Gly Lys Ile  Ser Thr Ser 
    4160                 4165                 4170             


Asp Asn  Ser Met Ala Gln Ile  Leu Thr Pro Asp Ser  Leu Asn Thr 
    4175                 4180                 4185             


Glu Gln  Gly Pro Glu Cys Ser  Leu Arg Pro Asn Gln  Thr Glu Glu 
    4190                 4195                 4200             


Gly Thr  Thr Pro Pro Ile Glu  Ala Asp Thr Leu Asp  Ser Ser Asp 
    4205                 4210                 4215             


Ala Gln  Gly Gly Leu Glu Pro  Arg Val Glu Lys Thr  Arg Pro Glu 
    4220                 4225                 4230             


Pro Thr  Glu Val Leu His Ala  Cys Lys Thr Gln Val  Ala Glu Leu 
    4235                 4240                 4245             


Glu Leu  Trp Leu Gln Gln Ala  Asn Val Ala Val Glu  Pro Glu Thr 
    4250                 4255                 4260             


Leu Asn  Ala Asp Met Gln Gln  Val Leu Glu Gln Gln  Leu Val Gly 
    4265                 4270                 4275             


Cys Gln  Ala Met Leu Thr Glu  Ile Glu His Lys Val  Ala Phe Leu 
    4280                 4285                 4290             


Leu Glu  Thr Cys Lys Asp Gln  Gly Leu Gly Asp Asn  Gly Ala Thr 
    4295                 4300                 4305             


Gln His  Glu Ala Glu Ala Leu  Ser Leu Lys Leu Lys  Thr Val Lys 
    4310                 4315                 4320             


Cys Asn  Leu Glu Lys Val Gln  Met Met Leu Gln Glu  Lys His Ser 
    4325                 4330                 4335             


Glu Asp  Gln His Pro Thr Ile  Leu Lys Lys Ser Ser  Glu Pro Glu 
    4340                 4345                 4350             


His Gln  Glu Ala Leu Gln Pro  Val Asn Leu Ser Glu  Leu Glu Ser 
    4355                 4360                 4365             


Ile Val  Thr Glu Arg Pro Gln  Phe Ser Arg Gln Lys  Asp Phe Gln 
    4370                 4375                 4380             


Gln Gln  Gln Val Leu Glu Leu  Lys Pro Met Glu Gln  Lys Asp Phe 
    4385                 4390                 4395             


Ile Lys  Phe Ile Glu Phe Asn  Ala Lys Lys Met Trp  Pro Gln Tyr 
    4400                 4405                 4410             


Cys Gln  His Asp Asn Asp Thr  Thr Gln Glu Ser Ser  Ala Ser Asn 
    4415                 4420                 4425             


Gln Ala  Ser Ser Pro Glu Asn  Asp Val Pro Asp Ser  Ile Leu Ser 
    4430                 4435                 4440             


Pro Gln  Gly Gln Asn Gly Asp  Lys Trp Gln Tyr Leu  His His Glu 
    4445                 4450                 4455             


Leu Ser  Ser Lys Ile Lys Leu  Pro Leu Pro Gln Leu  Val Glu Pro 
    4460                 4465                 4470             


Gln Val  Ser Thr Asn Met Gly  Ile Leu Pro Ser Val  Thr Met Tyr 
    4475                 4480                 4485             


Asn Phe  Arg Tyr Pro Thr Thr  Glu Glu Leu Lys Thr  Tyr Thr Thr 
    4490                 4495                 4500             


Gln Leu  Glu Asp Leu Arg Gln  Glu Ala Ser Asn Leu  Gln Thr Gln 
    4505                 4510                 4515             


Glu Asn  Met Thr Glu Glu Ala  Tyr Ile Asn Leu Asp  Lys Lys Leu 
    4520                 4525                 4530             


Phe Glu  Leu Phe Leu Thr Leu  Ser Gln Cys Leu Ser  Ser Val Glu 
    4535                 4540                 4545             


Glu Met  Leu Glu Met Pro Arg  Leu Tyr Arg Glu Asp  Gly Ser Gly 
    4550                 4555                 4560             


Gln Gln  Val His Tyr Glu Thr  Leu Ala Leu Glu Leu  Lys Lys Leu 
    4565                 4570                 4575             


Tyr Leu  Ala Leu Ser Asp Lys  Lys Gly Asp Leu Leu  Lys Ala Met 
    4580                 4585                 4590             


Thr Trp  Pro Gly Glu Asn Thr  Asn Leu Leu Leu Glu  Cys Phe Asp 
    4595                 4600                 4605             


Asn Leu  Gln Val Cys Leu Glu  His Thr Gln Ala Ala  Ala Val Cys 
    4610                 4615                 4620             


Arg Ser  Lys Ser Leu Lys Ala  Gly Leu Asp Tyr Asn  Arg Ser Tyr 
    4625                 4630                 4635             


Gln Asn  Glu Ile Lys Arg Leu  Tyr His Gln Leu Ile  Lys Ser Lys 
    4640                 4645                 4650             


Thr Ser  Leu Gln Gln Ser Leu  Asn Glu Ile Ser Gly  Gln Ser Val 
    4655                 4660                 4665             


Ala Glu  Gln Leu Gln Lys Ala  Asp Ala Tyr Thr Val  Glu Leu Glu 
    4670                 4675                 4680             


Asn Ala  Glu Ser Arg Val Ala  Lys Leu Arg Asp Glu  Gly Glu Arg 
    4685                 4690                 4695             


Leu His  Leu Pro Tyr Ala Leu  Leu Gln Glu Val Tyr  Lys Leu Glu 
    4700                 4705                 4710             


Asp Val  Leu Asp Ser Met Trp  Gly Met Leu Arg Ala  Arg Tyr Thr 
    4715                 4720                 4725             


Glu Leu  Ser Ser Pro Phe Val  Thr Glu Ser Gln Gln  Asp Ala Leu 
    4730                 4735                 4740             


Leu Gln  Gly Met Val Glu Leu  Val Lys Ile Gly Lys  Glu Lys Leu 
    4745                 4750                 4755             


Ala His  Gly His Leu Lys Gln  Thr Lys Ser Lys Val  Ala Leu Gln 
    4760                 4765                 4770             


Ala Gln  Ile Glu Asn His Lys  Val Phe Phe Gln Lys  Leu Val Ala 
    4775                 4780                 4785             


Asp Met  Leu Leu Ile Gln Ala  Tyr Ser Ala Lys Ile  Leu Pro Ser 
    4790                 4795                 4800             


Leu Leu  Gln Asn Arg Glu Thr  Phe Trp Ala Glu Gln  Val Thr Glu 
    4805                 4810                 4815             


Val Lys  Ile Leu Glu Glu Lys  Ser Arg Gln Cys Gly  Met Lys Leu 
    4820                 4825                 4830             


Gln Ser  Leu Leu Gln Lys Trp  Glu Glu Phe Asp Glu  Asn Tyr Ala 
    4835                 4840                 4845             


Ser Leu  Glu Lys Asp Leu Glu  Ile Leu Ile Ser Thr  Leu Pro Ser 
    4850                 4855                 4860             


Val Ser  Leu Val Glu Glu Thr  Glu Glu Arg Leu Val  Glu Arg Ile 
    4865                 4870                 4875             


Ser Phe  Tyr Gln Gln Ile Lys  Arg Asn Ile Gly Gly  Lys His Ala 
    4880                 4885                 4890             


Arg Leu  Tyr Gln Thr Leu Asn  Glu Gly Lys Gln Leu  Val Ala Ser 
    4895                 4900                 4905             


Val Ser  Cys Pro Glu Leu Glu  Gly Gln Ile Ala Lys  Leu Glu Glu 
    4910                 4915                 4920             


Gln Trp  Leu Ser Leu Asn Lys  Lys Ile Asp His Glu  Leu His Arg 
    4925                 4930                 4935             


Leu Gln  Ala Leu Leu Lys His  Leu Leu Ser Tyr Asn  Arg Asp Ser 
    4940                 4945                 4950             


Asp Gln  Leu Thr Lys Trp Leu  Glu Ser Ser Gln His  Thr Leu Asn 
    4955                 4960                 4965             


Tyr Trp  Lys Glu Gln Ser Leu  Asn Val Ser Gln Asp  Leu Asp Thr 
    4970                 4975                 4980             


Ile Arg  Ser Asn Ile Asn Asn  Phe Phe Glu Phe Ser  Lys Glu Val 
    4985                 4990                 4995             


Asp Glu  Lys Ser Ser Leu Lys  Thr Ala Val Ile Ser  Ile Gly Asn 
    5000                 5005                 5010             


Gln Leu  Leu His Leu Lys Glu  Thr Asp Thr Ala Thr  Leu Arg Ala 
    5015                 5020                 5025             


Ser Leu  Ala Gln Phe Glu Gln  Lys Trp Thr Met Leu  Ile Thr Gln 
    5030                 5035                 5040             


Leu Pro  Asp Ile Gln Glu Lys  Leu His Gln Leu Gln  Met Glu Lys 
    5045                 5050                 5055             


Leu Pro  Ser Arg Lys Ala Ile  Thr Glu Met Ile Ser  Trp Met Asn 
    5060                 5065                 5070             


Asn Val  Glu His Gln Thr Ser  Asp Glu Asp Ser Val  His Ser Pro 
    5075                 5080                 5085             


Ser Ser  Ala Ser Gln Val Lys  His Leu Leu Gln Lys  His Lys Glu 
    5090                 5095                 5100             


Phe Arg  Met Glu Met Asp Tyr  Lys Gln Trp Ile Val  Asp Phe Val 
    5105                 5110                 5115             


Asn Gln  Ser Leu Leu Gln Leu  Ser Thr Cys Asp Val  Glu Ser Lys 
    5120                 5125                 5130             


Arg Tyr  Glu Arg Thr Glu Phe  Ala Glu His Leu Gly  Glu Met Asn 
    5135                 5140                 5145             


Arg Gln  Trp His Arg Val His  Gly Met Leu Asn Arg  Lys Ile Gln 
    5150                 5155                 5160             


His Leu  Glu Gln Leu Leu Glu  Ser Ile Thr Glu Ser  Glu Asn Lys 
    5165                 5170                 5175             


Ile Gln  Ile Leu Asn Asn Trp  Leu Glu Ala Gln Glu  Glu Arg Leu 
    5180                 5185                 5190             


Lys Thr  Leu Gln Lys Pro Glu  Ser Val Ile Ser Val  Gln Lys Leu 
    5195                 5200                 5205             


Leu Leu  Asp Cys Gln Asp Ile  Glu Asn Gln Leu Ala  Ile Lys Ser 
    5210                 5215                 5220             


Lys Ala  Leu Asp Glu Leu Lys  Gln Ser Tyr Leu Thr  Leu Glu Ser 
    5225                 5230                 5235             


Gly Ala  Val Pro Leu Leu Glu  Asp Thr Ala Ser Arg  Ile Asp Glu 
    5240                 5245                 5250             


Leu Phe  Gln Lys Arg Ser Ser  Val Leu Thr Gln Val  Asn Gln Leu 
    5255                 5260                 5265             


Lys Thr  Ser Met Gln Ser Val  Leu Gln Glu Trp Lys  Ile Tyr Asp 
    5270                 5275                 5280             


Gln Leu  Tyr Asp Glu Val Asn  Met Met Thr Ile Arg  Phe Trp Tyr 
    5285                 5290                 5295             


Cys Met  Glu His Ser Lys Pro  Val Val Leu Ser Leu  Glu Thr Leu 
    5300                 5305                 5310             


Arg Cys  Gln Val Glu Asn Leu  Gln Ser Leu Gln Asp  Glu Ala Glu 
    5315                 5320                 5325             


Ser Ser  Glu Gly Ser Trp Glu  Lys Leu Gln Glu Val  Ile Gly Lys 
    5330                 5335                 5340             


Leu Lys  Gly Leu Cys Pro Ser  Val Ala Glu Ile Ile  Glu Glu Lys 
    5345                 5350                 5355             


Cys Gln  Asn Thr His Lys Arg  Trp Thr Gln Val Asn  Gln Ala Ile 
    5360                 5365                 5370             


Ala Asp  Gln Leu Gln Lys Ala  Gln Ser Leu Leu Gln  Leu Trp Lys 
    5375                 5380                 5385             


Ala Tyr  Ser Asn Ala His Gly  Glu Ala Ala Ala Arg  Leu Lys Gln 
    5390                 5395                 5400             


Gln Glu  Ala Lys Phe Gln Gln  Leu Ala Asn Ile Ser  Met Ser Gly 
    5405                 5410                 5415             


Asn Asn  Leu Ala Glu Ile Leu  Pro Pro Ala Leu Gln  Asp Ile Lys 
    5420                 5425                 5430             


Glu Leu  Gln His Asp Val Gln  Lys Thr Lys Glu Ala  Phe Leu Gln 
    5435                 5440                 5445             


Asn Ser  Ser Val Leu Asp Arg  Leu Pro Gln Pro Ala  Glu Ser Ser 
    5450                 5455                 5460             


Thr His  Met Leu Leu Pro Gly  Pro Leu His Ser Leu  Gln Arg Ala 
    5465                 5470                 5475             


Ala Tyr  Leu Glu Lys Met Leu  Leu Val Lys Ala Asn  Glu Phe Glu 
    5480                 5485                 5490             


Phe Val  Leu Ser Gln Phe Lys  Asp Phe Gly Val Arg  Leu Glu Ser 
    5495                 5500                 5505             


Leu Lys  Gly Leu Ile Met His  Glu Glu Glu Asn Leu  Asp Arg Leu 
    5510                 5515                 5520             


His Gln  Gln Glu Lys Glu Asn  Pro Asp Ser Phe Leu  Asn His Val 
    5525                 5530                 5535             


Leu Ala  Leu Thr Ala Gln Ser  Pro Asp Ile Glu His  Leu Asn Glu 
    5540                 5545                 5550             


Val Ser  Leu Lys Leu Pro Leu  Ser Asp Val Ala Val  Lys Thr Leu 
    5555                 5560                 5565             


Gln Asn  Met Asn Arg Gln Trp  Ile Arg Ala Thr Ala  Thr Ala Leu 
    5570                 5575                 5580             


Glu Arg  Cys Ser Glu Leu Gln  Gly Ile Gly Leu Asn  Glu Lys Phe 
    5585                 5590                 5595             


Leu Tyr  Cys Cys Glu Lys Trp  Ile Gln Leu Leu Glu  Lys Ile Glu 
    5600                 5605                 5610             


Glu Ala  Leu Lys Val Asp Val  Ala Asn Ser Leu Pro  Glu Leu Leu 
    5615                 5620                 5625             


Glu Gln  Gln Lys Thr Tyr Lys  Met Leu Glu Ala Glu  Val Ser Ile 
    5630                 5635                 5640             


Asn Gln  Thr Ile Ala Asp Ser  Tyr Val Thr Gln Ser  Leu Gln Leu 
    5645                 5650                 5655             


Leu Asp  Thr Thr Glu Ile Glu  Asn Arg Pro Glu Phe  Ile Thr Glu 
    5660                 5665                 5670             


Phe Ser  Lys Leu Thr Asp Arg  Trp Gln Asn Ala Val  Gln Gly Val 
    5675                 5680                 5685             


Arg Gln  Arg Lys Gly Asp Val  Asp Gly Leu Val Arg  Gln Trp Gln 
    5690                 5695                 5700             


Asp Phe  Thr Thr Ser Val Glu  Asn Leu Phe Arg Phe  Leu Thr Asp 
    5705                 5710                 5715             


Thr Ser  His Leu Leu Ser Ala  Val Lys Gly Gln Glu  Arg Phe Ser 
    5720                 5725                 5730             


Leu Tyr  Gln Thr Arg Ser Leu  Ile His Glu Leu Lys  Asn Lys Glu 
    5735                 5740                 5745             


Ile His  Phe Gln Arg Arg Arg  Thr Thr Cys Ala Leu  Thr Leu Glu 
    5750                 5755                 5760             


Ala Gly  Glu Lys Leu Leu Leu  Thr Thr Asp Leu Lys  Thr Lys Glu 
    5765                 5770                 5775             


Ser Val  Gly Arg Arg Ile Ser  Gln Leu Gln Asp Ser  Trp Lys Asp 
    5780                 5785                 5790             


Met Glu  Pro Gln Leu Ala Glu  Met Ile Lys Gln Phe  Gln Ser Thr 
    5795                 5800                 5805             


Val Glu  Thr Trp Asp Gln Cys  Glu Lys Lys Ile Lys  Glu Leu Lys 
    5810                 5815                 5820             


Ser Arg  Leu Gln Val Leu Lys  Ala Gln Ser Glu Asp  Pro Leu Pro 
    5825                 5830                 5835             


Glu Leu  His Glu Asp Leu His  Asn Glu Lys Glu Leu  Ile Lys Glu 
    5840                 5845                 5850             


Leu Glu  Gln Ser Leu Ala Ser  Trp Thr Gln Asn Leu  Lys Glu Leu 
    5855                 5860                 5865             


Gln Thr  Met Lys Ala Asp Leu  Thr Arg His Val Leu  Val Glu Asp 
    5870                 5875                 5880             


Val Met  Val Leu Lys Glu Gln  Ile Glu His Leu His  Arg Gln Trp 
    5885                 5890                 5895             


Glu Asp  Leu Cys Leu Arg Val  Ala Ile Arg Lys Gln  Glu Ile Glu 
    5900                 5905                 5910             


Asp Arg  Leu Asn Thr Trp Val  Val Phe Asn Glu Lys  Asn Lys Glu 
    5915                 5920                 5925             


Leu Cys  Ala Trp Leu Val Gln  Met Glu Asn Lys Val  Leu Gln Thr 
    5930                 5935                 5940             


Ala Asp  Ile Ser Ile Glu Glu  Met Ile Glu Lys Leu  Gln Lys Asp 
    5945                 5950                 5955             


Cys Met  Glu Glu Ile Asn Leu  Phe Ser Glu Asn Lys  Leu Gln Leu 
    5960                 5965                 5970             


Lys Gln  Met Gly Asp Gln Leu  Ile Lys Ala Ser Asn  Lys Ser Arg 
    5975                 5980                 5985             


Ala Ala  Glu Ile Asp Asp Lys  Leu Asn Lys Ile Asn  Asp Arg Trp 
    5990                 5995                 6000             


Gln His  Leu Phe Asp Val Ile  Gly Ser Arg Val Lys  Lys Leu Lys 
    6005                 6010                 6015             


Glu Thr  Phe Ala Phe Ile Gln  Gln Leu Asp Lys Asn  Met Ser Asn 
    6020                 6025                 6030             


Leu Arg  Thr Trp Leu Ala Arg  Ile Glu Ser Glu Leu  Ser Lys Pro 
    6035                 6040                 6045             


Val Val  Tyr Asp Val Cys Asp  Asp Gln Glu Ile Gln  Lys Arg Leu 
    6050                 6055                 6060             


Ala Glu  Gln Gln Asp Leu Gln  Arg Asp Ile Glu Gln  His Ser Ala 
    6065                 6070                 6075             


Gly Val  Glu Ser Val Phe Asn  Ile Cys Asp Val Leu  Leu His Asp 
    6080                 6085                 6090             


Ser Asp  Ala Cys Ala Asn Glu  Thr Glu Cys Asp Ser  Ile Gln Gln 
    6095                 6100                 6105             


Thr Thr  Arg Ser Leu Asp Arg  Arg Trp Arg Asn Ile  Cys Ala Met 
    6110                 6115                 6120             


Ser Met  Glu Arg Arg Met Lys  Ile Glu Glu Thr Trp  Arg Leu Trp 
    6125                 6130                 6135             


Gln Lys  Phe Leu Asp Asp Tyr  Ser Arg Phe Glu Asp  Trp Leu Lys 
    6140                 6145                 6150             


Ser Ala  Glu Arg Thr Ala Ala  Cys Pro Asn Ser Ser  Glu Val Leu 
    6155                 6160                 6165             


Tyr Thr  Ser Ala Lys Glu Glu  Leu Lys Arg Phe Glu  Ala Phe Gln 
    6170                 6175                 6180             


Arg Gln  Ile His Glu Arg Leu  Thr Gln Leu Glu Leu  Ile Asn Lys 
    6185                 6190                 6195             


Gln Tyr  Arg Arg Leu Ala Arg  Glu Asn Arg Thr Asp  Thr Ala Ser 
    6200                 6205                 6210             


Arg Leu  Lys Gln Met Val His  Glu Gly Asn Gln Arg  Trp Asp Asn 
    6215                 6220                 6225             


Leu Gln  Arg Arg Val Thr Ala  Val Leu Arg Arg Leu  Arg His Phe 
    6230                 6235                 6240             


Thr Asn  Gln Arg Glu Glu Phe  Glu Gly Thr Arg Glu  Ser Ile Leu 
    6245                 6250                 6255             


Val Trp  Leu Thr Glu Met Asp  Leu Gln Leu Thr Asn  Val Glu His 
    6260                 6265                 6270             


Phe Ser  Glu Ser Asp Ala Asp  Asp Lys Met Arg Gln  Leu Asn Gly 
    6275                 6280                 6285             


Phe Gln  Gln Glu Ile Thr Leu  Asn Thr Asn Lys Ile  Asp Gln Leu 
    6290                 6295                 6300             


Ile Val  Phe Gly Glu Gln Leu  Ile Gln Lys Ser Glu  Pro Leu Asp 
    6305                 6310                 6315             


Ala Val  Leu Ile Glu Asp Glu  Leu Glu Glu Leu His  Arg Tyr Cys 
    6320                 6325                 6330             


Gln Glu  Val Phe Gly Arg Val  Ser Arg Phe His Arg  Arg Leu Thr 
    6335                 6340                 6345             


Ser Cys  Thr Pro Gly Leu Glu  Asp Glu Lys Glu Ala  Ser Glu Asn 
    6350                 6355                 6360             


Glu Thr  Asp Met Glu Asp Pro  Arg Glu Ile Gln Thr  Asp Ser Trp 
    6365                 6370                 6375             


Arg Lys  Arg Gly Glu Ser Glu  Glu Pro Ser Ser Pro  Gln Ser Leu 
    6380                 6385                 6390             


Cys His  Leu Val Ala Pro Gly  His Glu Arg Ser Gly  Cys Glu Thr 
    6395                 6400                 6405             


Pro Val  Ser Val Asp Ser Ile  Pro Leu Glu Trp Asp  His Thr Gly 
    6410                 6415                 6420             


Asp Val  Gly Gly Ser Ser Ser  His Glu Glu Asp Glu  Glu Gly Pro 
    6425                 6430                 6435             


Tyr Tyr  Ser Ala Leu Ser Gly  Lys Ser Ile Ser Asp  Gly His Ser 
    6440                 6445                 6450             


Trp His  Val Pro Asp Ser Pro  Ser Cys Pro Glu His  His Tyr Lys 
    6455                 6460                 6465             


Gln Met  Glu Gly Asp Arg Asn  Val Pro Pro Val Pro  Pro Ala Ser 
    6470                 6475                 6480             


Ser Thr  Pro Tyr Lys Pro Pro  Tyr Gly Lys Leu Leu  Leu Pro Pro 
    6485                 6490                 6495             


Gly Thr  Asp Gly Gly Lys Glu  Gly Pro Arg Val Leu  Asn Gly Asn 
    6500                 6505                 6510             


Pro Gln  Gln Glu Asp Gly Gly  Leu Ala Gly Ile Thr  Glu Gln Gln 
    6515                 6520                 6525             


Ser Gly  Ala Phe Asp Arg Trp  Glu Met Ile Gln Ala  Gln Glu Leu 
    6530                 6535                 6540             


His Asn  Lys Leu Lys Ile Lys  Gln Asn Leu Gln Gln  Leu Asn Ser 
    6545                 6550                 6555             


Asp Ile  Ser Ala Ile Thr Thr  Trp Leu Lys Lys Thr  Glu Ala Glu 
    6560                 6565                 6570             


Leu Glu  Met Leu Lys Met Ala  Lys Pro Pro Ser Asp  Ile Gln Glu 
    6575                 6580                 6585             


Ile Glu  Leu Arg Val Lys Arg  Leu Gln Glu Ile Leu  Lys Ala Phe 
    6590                 6595                 6600             


Asp Thr  Tyr Lys Ala Leu Val  Val Ser Val Asn Val  Ser Ser Lys 
    6605                 6610                 6615             


Glu Phe  Leu Gln Thr Glu Ser  Pro Glu Ser Thr Glu  Leu Gln Ser 
    6620                 6625                 6630             


Arg Leu  Arg Gln Leu Ser Leu  Leu Trp Glu Ala Ala  Gln Gly Ala 
    6635                 6640                 6645             


Val Asp  Ser Trp Arg Gly Gly  Leu Arg Gln Ser Leu  Met Gln Cys 
    6650                 6655                 6660             


Gln Asp  Phe His Gln Leu Ser  Gln Asn Leu Leu Leu  Trp Leu Ala 
    6665                 6670                 6675             


Ser Ala  Lys Asn Arg Arg Gln  Lys Ala His Val Thr  Asp Pro Lys 
    6680                 6685                 6690             


Ala Asp  Pro Arg Ala Leu Leu  Glu Cys Arg Arg Glu  Leu Met Gln 
    6695                 6700                 6705             


Leu Glu  Lys Glu Leu Val Glu  Arg Gln Pro Gln Val  Asp Met Leu 
    6710                 6715                 6720             


Gln Glu  Ile Ser Asn Ser Leu  Leu Ile Lys Gly His  Gly Glu Asp 
    6725                 6730                 6735             


Cys Ile  Glu Ala Glu Glu Lys  Val His Val Ile Glu  Lys Lys Leu 
    6740                 6745                 6750             


Lys Gln  Leu Arg Glu Gln Val  Ser Gln Asp Leu Met  Ala Leu Gln 
    6755                 6760                 6765             


Gly Thr  Gln Asn Pro Ala Ser  Pro Leu Pro Ser Phe  Asp Glu Val 
    6770                 6775                 6780             


Asp Ser  Gly Asp Gln Pro Pro  Ala Thr Ser Val Pro  Ala Pro Arg 
    6785                 6790                 6795             


Ala Lys  Gln Phe Arg Ala Val  Arg Thr Thr Glu Gly  Glu Glu Glu 
    6800                 6805                 6810             


Thr Glu  Ser Arg Val Pro Gly  Ser Thr Arg Pro Gln  Arg Ser Phe 
    6815                 6820                 6825             


Leu Ser  Arg Val Val Arg Ala  Ala Leu Pro Leu Gln  Leu Leu Leu 
    6830                 6835                 6840             


Leu Leu  Leu Leu Leu Leu Ala  Cys Leu Leu Pro Ser  Ser Glu Glu 
    6845                 6850                 6855             


Asp Tyr  Ser Cys Thr Gln Ala  Asn Asn Phe Ala Arg  Ser Phe Tyr 
    6860                 6865                 6870             


Pro Met  Leu Arg Tyr Thr Asn  Gly Pro Pro Pro Thr  
    6875                 6880                 6885 


<210>  1549
<211>  431
<212>  PRT
<213>  homo sapiens

<400>  1549

Met Ala Glu Ile Thr Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val 
1               5                   10                  15      


Val Ala Gly Leu Ile Gly Ala Ser Val Leu Val Val Cys Val Ser Val 
            20                  25                  30          


Thr Val Phe Val Trp Ser Cys Cys His Gln Gln Ala Glu Lys Lys Gln 
        35                  40                  45              


Lys Asn Pro Pro Tyr Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile 
    50                  55                  60                  


Tyr Pro Glu Thr Leu Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg 
65                  70                  75                  80  


Asp Lys Asp Gly Pro Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val 
                85                  90                  95      


Asp Ala Ala Glu Ala Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly 
            100                 105                 110         


Pro Ser Ser Gly Ser Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr 
        115                 120                 125             


Gly Glu Glu Leu Arg Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser 
    130                 135                 140                 


Lys Thr Thr Ser Pro Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser 
145                 150                 155                 160 


Leu Thr Phe Ser Val Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val 
                165                 170                 175     


Thr Ile Gln Glu Ala His Gly Leu Pro Val Met Asp Asp Gln Thr Gln 
            180                 185                 190         


Gly Ser Asp Pro Tyr Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His 
        195                 200                 205             


Arg Val Lys Thr Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp 
    210                 215                 220                 


Glu Thr Phe Thr Phe Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu 
225                 230                 235                 240 


Val Leu His Phe Leu Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp 
                245                 250                 255     


Val Ile Gly Glu Val Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr 
            260                 265                 270         


Gly Lys Val Gln Leu Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys 
        275                 280                 285             


Cys Ile Ser Arg Gly Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val 
    290                 295                 300                 


Ala Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys 
305                 310                 315                 320 


Met Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn Val 
                325                 330                 335     


Tyr Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys Lys 
            340                 345                 350         


Cys Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro 
        355                 360                 365             


Thr Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp Phe 
    370                 375                 380                 


Asp Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly Ala 
385                 390                 395                 400 


His Ser Val Thr Ala Ser Gly Ala Glu His Trp Arg Glu Val Cys Glu 
                405                 410                 415     


Ser Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr 
            420                 425                 430     


<210>  1550
<211>  527
<212>  PRT
<213>  homo sapiens

<400>  1550

Met Ser Asp Thr Leu Thr Ala Asp Val Ile Gly Arg Arg Val Glu Val 
1               5                   10                  15      


Asn Gly Glu His Ala Thr Val Arg Phe Ala Gly Val Val Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Trp Leu Gly Val Glu Trp Asp Asn Pro Glu Arg Gly Lys 
        35                  40                  45              


His Asp Gly Ser His Glu Gly Thr Val Tyr Phe Lys Cys Arg His Pro 
    50                  55                  60                  


Thr Gly Gly Ser Phe Ile Arg Pro Asn Lys Val Asn Phe Gly Thr Asp 
65                  70                  75                  80  


Phe Leu Thr Ala Ile Lys Asn Arg Tyr Val Leu Glu Asp Gly Pro Glu 
                85                  90                  95      


Glu Asp Arg Lys Glu Gln Ile Val Thr Ile Gly Asn Lys Pro Val Glu 
            100                 105                 110         


Thr Ile Gly Phe Asp Ser Ile Met Lys Gln Gln Ser Gln Leu Ser Lys 
        115                 120                 125             


Leu Gln Glu Val Ser Leu Arg Asn Cys Ala Val Ser Cys Ala Gly Glu 
    130                 135                 140                 


Lys Gly Gly Val Ala Glu Ala Cys Pro Asn Ile Arg Lys Val Asp Leu 
145                 150                 155                 160 


Ser Lys Asn Leu Leu Ser Ser Trp Asp Glu Val Ile His Ile Ala Asp 
                165                 170                 175     


Gln Leu Arg His Leu Glu Val Leu Asn Val Ser Glu Asn Lys Leu Lys 
            180                 185                 190         


Phe Pro Ser Gly Ser Val Leu Thr Gly Thr Leu Ser Val Leu Lys Val 
        195                 200                 205             


Leu Val Leu Asn Gln Thr Gly Ile Thr Trp Ala Glu Val Leu Arg Cys 
    210                 215                 220                 


Val Ala Gly Cys Pro Gly Leu Glu Glu Leu Tyr Leu Glu Ser Asn Asn 
225                 230                 235                 240 


Ile Phe Ile Ser Glu Arg Pro Thr Asp Val Leu Gln Thr Val Lys Leu 
                245                 250                 255     


Leu Asp Leu Ser Ser Asn Gln Leu Ile Asp Glu Asn Gln Leu Tyr Leu 
            260                 265                 270         


Ile Ala His Leu Pro Arg Leu Glu Gln Leu Ile Leu Ser Asp Thr Gly 
        275                 280                 285             


Ile Ser Ser Leu His Phe Pro Asp Ala Gly Ile Gly Cys Lys Thr Ser 
    290                 295                 300                 


Met Phe Pro Ser Leu Lys Tyr Leu Val Val Asn Asp Asn Gln Ile Ser 
305                 310                 315                 320 


Gln Trp Ser Phe Phe Asn Glu Leu Glu Lys Leu Pro Ser Leu Arg Ala 
                325                 330                 335     


Leu Ser Cys Leu Arg Asn Pro Leu Thr Lys Glu Asp Lys Glu Ala Glu 
            340                 345                 350         


Thr Ala Arg Leu Leu Ile Ile Ala Ser Ile Gly Gln Leu Lys Thr Leu 
        355                 360                 365             


Asn Lys Cys Glu Ile Leu Pro Glu Glu Arg Arg Arg Ala Glu Leu Asp 
    370                 375                 380                 


Tyr Arg Lys Ala Phe Gly Asn Glu Trp Lys Gln Ala Gly Gly His Lys 
385                 390                 395                 400 


Asp Pro Glu Lys Asn Arg Leu Ser Glu Glu Phe Leu Thr Ala His Pro 
                405                 410                 415     


Arg Tyr Gln Phe Leu Cys Leu Lys Tyr Gly Ala Pro Glu Asp Trp Glu 
            420                 425                 430         


Leu Lys Thr Gln Gln Pro Leu Met Leu Lys Asn Gln Leu Leu Thr Leu 
        435                 440                 445             


Lys Ile Lys Tyr Pro His Gln Leu Asp Gln Lys Val Leu Glu Lys Gln 
    450                 455                 460                 


Leu Pro Gly Ser Met Thr Ile Gln Lys Val Lys Gly Leu Leu Ser Arg 
465                 470                 475                 480 


Leu Leu Lys Val Pro Val Ser Asp Leu Leu Leu Ser Tyr Glu Ser Pro 
                485                 490                 495     


Lys Lys Pro Gly Arg Glu Ile Glu Leu Glu Asn Asp Leu Lys Ser Leu 
            500                 505                 510         


Gln Phe Tyr Ser Val Glu Asn Gly Asp Cys Leu Leu Val Arg Trp 
        515                 520                 525         


<210>  1551
<211>  682
<212>  PRT
<213>  homo sapiens

<400>  1551

Met Asn Pro Gln Gln Gln Arg Met Ala Ala Ile Gly Thr Asp Lys Glu 
1               5                   10                  15      


Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Asn 
            20                  25                  30          


Ser Gly Lys Thr Arg Pro Thr Thr Leu Gly Ser Ser Gln Phe Ser Gly 
        35                  40                  45              


Ser Gly Ile Asp Glu Arg Gly Gly Thr Thr Ser Trp Gly Thr Ser Gly 
    50                  55                  60                  


Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe Thr Asp Ser Pro 
65                  70                  75                  80  


His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Ala His Glu Gly 
                85                  90                  95      


Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Met Gly Lys Thr Ser 
            100                 105                 110         


Glu Arg Gly Ser Phe Ser Leu Tyr Ser Arg Asp Thr Gly Leu Pro Gly 
        115                 120                 125             


Cys Gln Ser Ser Leu Leu Arg Gln Asp Leu Gly Leu Gly Ser Pro Ala 
    130                 135                 140                 


Gln Leu Ser Ser Ser Gly Lys Pro Gly Thr Ala Tyr Tyr Ser Phe Ser 
145                 150                 155                 160 


Ala Thr Ser Ser Arg Arg Arg Pro Leu His Asp Ser Ala Ala Leu Asp 
                165                 170                 175     


Pro Leu Gln Ala Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser 
            180                 185                 190         


Ser Val Tyr Ala Pro Ser Pro Asn Ser Asp Asp Phe Asn Arg Glu Ser 
        195                 200                 205             


Pro Ser Tyr Pro Ser Pro Lys Pro Pro Thr Ser Met Phe Ala Ser Thr 
    210                 215                 220                 


Phe Phe Met Gln Asp Gly Thr His Asn Ser Ser Asp Leu Trp Ser Ser 
225                 230                 235                 240 


Ser Asn Gly Met Ser Gln Pro Gly Phe Gly Gly Ile Leu Gly Thr Ser 
                245                 250                 255     


Thr Ser His Met Ser Gln Ser Ser Ser Tyr Gly Asn Leu His Ser His 
            260                 265                 270         


Asp Arg Leu Ser Tyr Pro Pro His Ser Val Ser Pro Thr Asp Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Pro Met Ser Ser Phe His Arg Gly Ser Thr Ser Ser 
    290                 295                 300                 


Ser Pro Tyr Val Ala Ala Ser His Thr Pro Pro Ile Asn Gly Ser Asp 
305                 310                 315                 320 


Ser Ile Leu Gly Thr Arg Gly Asn Ala Ala Gly Ser Ser Gln Thr Gly 
                325                 330                 335     


Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr 
            340                 345                 350         


Ser Ser Ser Phe Pro Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Ser 
        355                 360                 365             


Pro Leu Thr Gly Thr Ser Gln Trp Pro Arg Pro Gly Gly Gln Ala Pro 
    370                 375                 380                 


Ser Ser Pro Ser Tyr Glu Asn Ser Leu His Ser Leu Gln Ser Arg Met 
385                 390                 395                 400 


Glu Asp Arg Leu Asp Arg Leu Asp Asp Ala Ile His Val Leu Arg Asn 
                405                 410                 415     


His Ala Val Gly Pro Ser Thr Ser Leu Pro Ala Gly His Ser Asp Ile 
            420                 425                 430         


His Ser Leu Leu Gly Pro Ser His Asn Ala Pro Ile Gly Ser Leu Asn 
        435                 440                 445             


Ser Asn Tyr Gly Gly Ser Ser Leu Val Ala Ser Ser Arg Ser Ala Ser 
    450                 455                 460                 


Met Val Gly Thr His Arg Glu Asp Ser Val Ser Leu Asn Gly Asn His 
465                 470                 475                 480 


Ser Val Leu Ser Ser Thr Val Thr Thr Ser Ser Thr Asp Leu Asn His 
                485                 490                 495     


Lys Thr Gln Glu Asn Tyr Arg Gly Gly Leu Gln Ser Gln Ser Gly Thr 
            500                 505                 510         


Val Val Thr Thr Glu Ile Lys Thr Glu Asn Lys Glu Lys Asp Glu Asn 
        515                 520                 525             


Leu His Glu Pro Pro Ser Ser Asp Asp Met Lys Ser Asp Asp Glu Ser 
    530                 535                 540                 


Ser Gln Lys Asp Ile Lys Val Ser Ser Arg Gly Arg Thr Ser Ser Thr 
545                 550                 555                 560 


Asn Glu Asp Glu Asp Leu Asn Pro Glu Gln Lys Ile Glu Arg Glu Lys 
                565                 570                 575     


Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg Val Arg Asp 
            580                 585                 590         


Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys Gln Leu His Leu 
        595                 600                 605             


Lys Ser Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu His Gln Ala Val 
    610                 615                 620                 


Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg Asn Leu Asn 
625                 630                 635                 640 


Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys Val Ser Ala 
                645                 650                 655     


Val Ser Ala Glu Pro Pro Thr Thr Leu Pro Gly Thr His Pro Gly Leu 
            660                 665                 670         


Ser Glu Thr Thr Asn Pro Met Gly His Met 
        675                 680         


<210>  1552
<211>  596
<212>  PRT
<213>  homo sapiens

<400>  1552

Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 
1               5                   10                  15      


Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 
            20                  25                  30          


Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 
        35                  40                  45              


Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 
    50                  55                  60                  


Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 
65                  70                  75                  80  


Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 
                85                  90                  95      


Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 
            100                 105                 110         


Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr 
        115                 120                 125             


Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln 
    130                 135                 140                 


Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile 
145                 150                 155                 160 


Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro 
                165                 170                 175     


Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn 
            180                 185                 190         


Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro 
        195                 200                 205             


Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro 
    210                 215                 220                 


Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Leu Val Pro Gln 
225                 230                 235                 240 


Gln Gly Gln Pro Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro 
                245                 250                 255     


Tyr Pro Thr Ala Leu Thr Val Asn Ala Ser Met Ser Arg Phe Pro Pro 
            260                 265                 270         


His Met Val Pro Pro His His Thr Leu His Thr Thr Gly Ile Pro His 
        275                 280                 285             


Pro Ala Ile Val Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp 
    290                 295                 300                 


Val Gly Ser Leu His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu 
305                 310                 315                 320 


Glu Lys Lys Lys Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu 
                325                 330                 335     


Tyr Met Lys Glu Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys 
            340                 345                 350         


Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu 
        355                 360                 365             


Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg 
    370                 375                 380                 


Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr 
385                 390                 395                 400 


Gly Lys Lys Lys Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn 
                405                 410                 415     


Glu His Ser Glu Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile 
            420                 425                 430         


Thr Asp Leu Ser Ala Pro Lys Lys Cys Arg Ala Arg Phe Gly Leu Asp 
        435                 440                 445             


Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys Cys Val 
    450                 455                 460                 


Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu Ser Pro Pro Ser Ser Asp 
465                 470                 475                 480 


Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser Pro Asn Leu Leu Gly Ser 
                485                 490                 495     


Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu Gln Thr Gln Pro Leu Ser 
            500                 505                 510         


Leu Ser Leu Lys Pro Asp Pro Leu Ala His Leu Ser Met Met Pro Pro 
        515                 520                 525             


Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr His Lys Ala Ser Ala Leu 
    530                 535                 540                 


Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro Ala Ala Leu Gln Pro Ala 
545                 550                 555                 560 


Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser Thr Ser Ser Leu His Ser 
                565                 570                 575     


His Ser Ser Leu Ala Gly Thr Gln Pro Gln Pro Leu Ser Leu Val Thr 
            580                 585                 590         


Lys Ser Leu Glu 
        595     


<210>  1553
<211>  837
<212>  PRT
<213>  homo sapiens

<400>  1553

Met Ser Leu Ser His Leu Tyr Arg Asp Gly Glu Gly Arg Ile Asp Asp 
1               5                   10                  15      


Asp Asp Asp Glu Arg Glu Asn Phe Glu Ile Thr Asp Trp Asp Leu Gln 
            20                  25                  30          


Asn Glu Phe Asn Pro Asn Arg Gln Arg His Trp Gln Thr Lys Glu Glu 
        35                  40                  45              


Ala Thr Tyr Gly Val Trp Ala Glu Arg Asp Ser Asp Asp Glu Arg Pro 
    50                  55                  60                  


Ser Phe Gly Gly Lys Arg Ala Arg Asp Tyr Ser Ala Pro Val Asn Phe 
65                  70                  75                  80  


Ile Ser Ala Gly Leu Lys Lys Gly Ala Ala Glu Glu Ala Glu Leu Glu 
                85                  90                  95      


Asp Ser Asp Asp Glu Glu Lys Pro Val Lys Gln Asp Asp Phe Pro Lys 
            100                 105                 110         


Asp Phe Gly Pro Arg Lys Leu Lys Thr Gly Gly Asn Phe Lys Pro Ser 
        115                 120                 125             


Gln Lys Gly Phe Ala Gly Gly Thr Lys Ser Phe Met Asp Phe Gly Ser 
    130                 135                 140                 


Trp Glu Arg His Thr Lys Gly Ile Gly Gln Lys Leu Leu Gln Lys Met 
145                 150                 155                 160 


Gly Tyr Val Pro Gly Arg Gly Leu Gly Lys Asn Ala Gln Gly Ile Ile 
                165                 170                 175     


Asn Pro Ile Glu Ala Lys Gln Arg Lys Gly Lys Gly Ala Val Gly Ala 
            180                 185                 190         


Tyr Gly Ser Glu Arg Thr Thr Gln Ser Met Gln Asp Phe Pro Val Val 
        195                 200                 205             


Asp Ser Glu Glu Glu Ala Glu Glu Glu Phe Gln Lys Glu Leu Ser Gln 
    210                 215                 220                 


Trp Arg Lys Asp Pro Ser Gly Ser Lys Lys Lys Pro Lys Tyr Ser Tyr 
225                 230                 235                 240 


Lys Thr Val Glu Glu Leu Lys Ala Lys Gly Arg Ile Ser Lys Lys Leu 
                245                 250                 255     


Thr Ala Pro Gln Lys Glu Leu Ser Gln Val Lys Val Ile Asp Met Thr 
            260                 265                 270         


Gly Arg Glu Gln Lys Val Tyr Tyr Ser Tyr Ser Gln Ile Ser His Lys 
        275                 280                 285             


His Asn Val Pro Asp Asp Gly Leu Pro Leu Gln Ser Gln Gln Leu Pro 
    290                 295                 300                 


Gln Ser Gly Lys Glu Ala Lys Ala Pro Gly Phe Ala Leu Pro Glu Leu 
305                 310                 315                 320 


Glu His Asn Leu Gln Leu Leu Ile Asp Leu Thr Glu Gln Glu Ile Ile 
                325                 330                 335     


Gln Asn Asp Arg Gln Leu Gln Tyr Glu Arg Asp Met Val Val Asn Leu 
            340                 345                 350         


Phe His Glu Leu Glu Lys Met Thr Glu Val Leu Asp His Glu Glu Arg 
        355                 360                 365             


Val Ile Ser Asn Leu Ser Lys Val Leu Glu Met Val Glu Glu Cys Glu 
    370                 375                 380                 


Arg Arg Met Gln Pro Asp Cys Ser Asn Pro Leu Thr Leu Asp Glu Cys 
385                 390                 395                 400 


Ala Arg Ile Phe Glu Thr Leu Gln Asp Lys Tyr Tyr Glu Glu Tyr Arg 
                405                 410                 415     


Met Ser Asp Arg Val Asp Leu Ala Val Ala Ile Val Tyr Pro Leu Met 
            420                 425                 430         


Lys Glu Tyr Phe Lys Glu Trp Asp Pro Leu Lys Asp Cys Thr Tyr Gly 
        435                 440                 445             


Thr Glu Ile Ile Ser Lys Trp Lys Ser Leu Leu Glu Asn Asp Gln Leu 
    450                 455                 460                 


Leu Ser His Gly Gly Gln Asp Leu Ser Ala Asp Ala Phe His Arg Leu 
465                 470                 475                 480 


Ile Trp Glu Val Trp Met Pro Phe Val Arg Asn Ile Val Thr Gln Trp 
                485                 490                 495     


Gln Pro Arg Asn Cys Asp Pro Met Val Asp Phe Leu Asp Ser Trp Val 
            500                 505                 510         


His Ile Ile Pro Val Trp Ile Leu Asp Asn Ile Leu Asp Gln Leu Ile 
        515                 520                 525             


Phe Pro Lys Leu Gln Lys Glu Val Glu Asn Trp Asn Pro Leu Thr Asp 
    530                 535                 540                 


Thr Val Pro Ile His Ser Trp Ile His Pro Trp Leu Pro Leu Met Gln 
545                 550                 555                 560 


Ala Arg Leu Glu Pro Leu Tyr Ser Pro Ile Arg Ser Lys Leu Ser Ser 
                565                 570                 575     


Ala Leu Gln Lys Trp His Pro Ser Asp Ser Ser Ala Lys Leu Ile Leu 
            580                 585                 590         


Gln Pro Trp Lys Asp Val Phe Thr Pro Gly Ser Trp Glu Ala Phe Met 
        595                 600                 605             


Val Lys Asn Ile Val Pro Lys Leu Gly Met Cys Leu Gly Glu Leu Val 
    610                 615                 620                 


Ile Asn Pro His Gln Gln His Met Asp Ala Phe Tyr Trp Val Ile Asp 
625                 630                 635                 640 


Trp Glu Gly Met Ile Ser Val Ser Ser Leu Val Gly Leu Leu Glu Lys 
                645                 650                 655     


His Phe Phe Pro Lys Trp Leu Gln Val Leu Cys Ser Trp Leu Ser Asn 
            660                 665                 670         


Ser Pro Asn Tyr Glu Glu Ile Thr Lys Trp Tyr Leu Gly Trp Lys Ser 
        675                 680                 685             


Met Phe Ser Asp Gln Val Leu Ala His Pro Ser Val Lys Asp Lys Phe 
    690                 695                 700                 


Asn Glu Ala Leu Asp Ile Met Asn Arg Ala Val Ser Ser Asn Val Gly 
705                 710                 715                 720 


Ala Tyr Met Gln Pro Gly Ala Arg Glu Asn Ile Ala Tyr Leu Thr His 
                725                 730                 735     


Thr Glu Arg Arg Lys Asp Phe Gln Tyr Glu Ala Met Gln Glu Arg Arg 
            740                 745                 750         


Glu Ala Glu Asn Met Ala Gln Arg Gly Ile Gly Val Ala Ala Ser Ser 
        755                 760                 765             


Val Pro Met Asn Phe Lys Asp Leu Ile Glu Thr Lys Ala Glu Glu His 
    770                 775                 780                 


Asn Ile Val Phe Met Pro Val Ile Gly Lys Arg His Glu Gly Lys Gln 
785                 790                 795                 800 


Leu Tyr Thr Phe Gly Arg Ile Val Ile Tyr Ile Asp Arg Gly Val Val 
                805                 810                 815     


Phe Val Gln Gly Glu Lys Thr Trp Val Pro Thr Ser Leu Gln Ser Leu 
            820                 825                 830         


Ile Asp Met Ala Lys 
        835         


<210>  1554
<211>  853
<212>  PRT
<213>  homo sapiens

<400>  1554

Met Cys Cys Glu Lys Trp Ser Arg Val Ala Glu Met Phe Leu Phe Ile 
1               5                   10                  15      


Glu Glu Arg Glu Asp Cys Lys Ile Leu Cys Leu Cys Ser Arg Ala Phe 
            20                  25                  30          


Val Glu Asp Arg Lys Leu Tyr Asn Leu Gly Leu Lys Gly Tyr Tyr Ile 
        35                  40                  45              


Arg Asp Ser Gly Asn Asn Ser Gly Asp Gln Ala Thr Glu Glu Glu Glu 
    50                  55                  60                  


Gly Gly Tyr Ser Cys Gly Thr Ala Glu Ser His Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Gly Leu Asp Glu Ser Glu Leu Asp Ser Glu Ala Glu Leu Met Arg Ser 
                85                  90                  95      


Met Gly Leu Pro Leu Gln Phe Gly Arg Ile Thr Ala His Lys Asp Phe 
            100                 105                 110         


Glu Val Ser Met Asn Thr Arg Asn Lys Val Lys Ile Lys Lys Lys Lys 
        115                 120                 125             


His Gln Lys Lys Tyr Leu Asp Glu Ile Val Gln Glu Ser Trp Arg Lys 
    130                 135                 140                 


Glu Tyr Glu Glu Asp Asp Ile Leu Ala Ser Asp Asp Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Gln Tyr Glu Asn Thr Arg Thr Tyr Glu Leu Gln Ser Lys Lys Asp 
                165                 170                 175     


Thr Glu Thr Glu Asn Pro Pro Val Glu Asn Thr Leu Ser Pro Lys Leu 
            180                 185                 190         


Glu Ile Thr Glu Lys Trp Glu Lys Tyr Trp Asn Glu Tyr Gly Gly Gly 
        195                 200                 205             


Leu Leu Trp Gln Ser Trp Gln Glu Lys His Pro Gly Gln Ala Leu Ser 
    210                 215                 220                 


Ser Glu Pro Trp Asn Phe Pro Asp Thr Lys Glu Glu Trp Glu Gln His 
225                 230                 235                 240 


Tyr Ser Gln Leu Tyr Trp Tyr Tyr Leu Glu Gln Phe Gln Tyr Trp Glu 
                245                 250                 255     


Ala Gln Gly Trp Thr Phe Asp Ala Ser Gln Ser Cys Asp Thr Asp Thr 
            260                 265                 270         


Tyr Thr Ser Lys Thr Glu Ala Asp Asp Lys Asn Asp Glu Lys Cys Met 
        275                 280                 285             


Lys Val Asp Leu Val Ser Phe Pro Ser Ser Pro Ile Met Val Asp Asn 
    290                 295                 300                 


Asp Ser Ser Gly Thr Ser Asp Lys Asp His Ser Glu Ile Leu Asp Gly 
305                 310                 315                 320 


Ile Ser Asn Ile Lys Leu Asn Ser Glu Glu Val Thr Gln Ser Gln Leu 
                325                 330                 335     


Asp Ser Cys Thr Ser His Asp Gly His Gln Gln Leu Ser Glu Val Ser 
            340                 345                 350         


Ser Lys Arg Glu Cys Pro Ala Ser Gly Gln Ser Glu Pro Arg Asn Gly 
        355                 360                 365             


Gly Thr Asn Glu Glu Ser Asn Ser Ser Gly Asn Thr Asn Thr Asp Pro 
    370                 375                 380                 


Pro Ala Glu Asp Ser Gln Lys Ser Ser Gly Ala Asn Thr Ser Lys Asp 
385                 390                 395                 400 


Arg Pro His Ala Ser Gly Thr Asp Gly Asp Glu Ser Glu Glu Asp Pro 
                405                 410                 415     


Pro Glu His Lys Pro Ser Lys Leu Lys Arg Ser His Glu Leu Asp Ile 
            420                 425                 430         


Asp Glu Asn Pro Ala Ser Asp Phe Asp Asp Ser Gly Ser Leu Leu Gly 
        435                 440                 445             


Phe Lys Tyr Gly Ser Gly Gln Lys Tyr Gly Gly Ile Pro Asn Phe Ser 
    450                 455                 460                 


His Arg Gln Val Arg Tyr Leu Glu Lys Asn Val Lys Leu Lys Ser Lys 
465                 470                 475                 480 


Tyr Leu Asp Met Arg Arg Gln Ile Lys Met Lys Asn Lys His Ile Phe 
                485                 490                 495     


Phe Thr Lys Glu Ser Glu Lys Pro Phe Phe Lys Lys Ser Lys Ile Leu 
            500                 505                 510         


Ser Lys Val Glu Lys Phe Leu Thr Trp Val Asn Lys Pro Met Asp Glu 
        515                 520                 525             


Glu Ala Ser Gln Glu Ser Ser Ser His Asp Asn Val His Asp Ala Ser 
    530                 535                 540                 


Thr Ser Ser Asp Ser Glu Glu Gln Asp Met Ser Val Lys Lys Gly Asp 
545                 550                 555                 560 


Asp Leu Leu Glu Thr Asn Asn Pro Glu Pro Glu Lys Cys Gln Ser Val 
                565                 570                 575     


Ser Ser Ala Gly Glu Leu Glu Thr Glu Asn Tyr Glu Arg Asp Ser Leu 
            580                 585                 590         


Leu Ala Thr Val Pro Asp Glu Gln Asp Cys Val Thr Gln Glu Val Pro 
        595                 600                 605             


Asp Ser Arg Gln Ala Glu Thr Glu Ala Glu Val Lys Lys Lys Lys Asn 
    610                 615                 620                 


Lys Lys Lys Asn Lys Lys Val Asn Gly Leu Pro Pro Glu Ile Ala Ala 
625                 630                 635                 640 


Val Pro Glu Leu Ala Lys Tyr Trp Ala Gln Arg Tyr Arg Leu Phe Ser 
                645                 650                 655     


Arg Phe Asp Asp Gly Ile Lys Leu Asp Arg Glu Gly Trp Phe Ser Val 
            660                 665                 670         


Thr Pro Glu Lys Ile Ala Glu His Ile Ala Gly Arg Val Ser Gln Ser 
        675                 680                 685             


Phe Lys Cys Asp Val Val Val Asp Ala Phe Cys Gly Val Gly Gly Asn 
    690                 695                 700                 


Thr Ile Gln Phe Ala Leu Thr Gly Met Arg Val Ile Ala Ile Asp Ile 
705                 710                 715                 720 


Asp Pro Val Lys Ile Ala Leu Ala Arg Asn Asn Ala Glu Val Tyr Gly 
                725                 730                 735     


Ile Ala Asp Lys Ile Glu Phe Ile Cys Gly Asp Phe Leu Leu Leu Ala 
            740                 745                 750         


Ser Phe Leu Lys Ala Asp Val Val Phe Leu Ser Pro Pro Trp Gly Gly 
        755                 760                 765             


Pro Asp Tyr Ala Thr Ala Glu Thr Phe Asp Ile Arg Thr Met Met Ser 
    770                 775                 780                 


Pro Asp Gly Phe Glu Ile Phe Arg Leu Ser Lys Lys Ile Thr Asn Asn 
785                 790                 795                 800 


Ile Val Tyr Phe Leu Pro Arg Asn Ala Asp Ile Asp Gln Val Ala Ser 
                805                 810                 815     


Leu Ala Gly Pro Gly Gly Gln Val Glu Ile Glu Gln Asn Phe Leu Asn 
            820                 825                 830         


Asn Lys Leu Lys Thr Ile Thr Ala Tyr Phe Gly Asp Leu Ile Arg Arg 
        835                 840                 845             


Pro Ala Ser Glu Thr 
    850             


<210>  1555
<211>  1593
<212>  PRT
<213>  homo sapiens

<400>  1555

Met Ala Ala Ala Ala Val Val Val Pro Ala Glu Trp Ile Lys Asn Trp 
1               5                   10                  15      


Glu Lys Ser Gly Arg Gly Glu Phe Leu His Leu Cys Arg Ile Leu Ser 
            20                  25                  30          


Glu Asn Lys Ser His Asp Ser Ser Thr Tyr Arg Asp Phe Gln Gln Ala 
        35                  40                  45              


Leu Tyr Glu Leu Ser Tyr His Val Ile Lys Gly Asn Leu Lys His Glu 
    50                  55                  60                  


Gln Ala Ser Asn Val Leu Ser Asp Ile Ser Glu Phe Arg Glu Asp Met 
65                  70                  75                  80  


Pro Ser Ile Leu Ala Asp Val Phe Cys Ile Leu Asp Ile Glu Thr Asn 
                85                  90                  95      


Cys Leu Glu Glu Lys Ser Lys Arg Asp Tyr Phe Thr Gln Leu Val Leu 
            100                 105                 110         


Ala Cys Leu Tyr Leu Val Ser Asp Thr Val Leu Lys Glu Arg Leu Asp 
        115                 120                 125             


Pro Glu Thr Leu Glu Ser Leu Gly Leu Ile Lys Gln Ser Gln Gln Phe 
    130                 135                 140                 


Asn Gln Lys Ser Val Lys Ile Lys Thr Lys Leu Phe Tyr Lys Gln Gln 
145                 150                 155                 160 


Lys Phe Asn Leu Leu Arg Glu Glu Asn Glu Gly Tyr Ala Lys Leu Ile 
                165                 170                 175     


Ala Glu Leu Gly Gln Asp Leu Ser Gly Ser Ile Thr Ser Asp Leu Ile 
            180                 185                 190         


Leu Glu Asn Ile Lys Ser Leu Ile Gly Cys Phe Asn Leu Asp Pro Asn 
        195                 200                 205             


Arg Val Leu Asp Val Ile Leu Glu Val Phe Glu Cys Arg Pro Glu His 
    210                 215                 220                 


Asp Asp Phe Phe Ile Ser Leu Leu Glu Ser Tyr Met Ser Met Cys Glu 
225                 230                 235                 240 


Pro Gln Thr Leu Cys His Ile Leu Gly Phe Lys Phe Lys Phe Tyr Gln 
                245                 250                 255     


Glu Pro Asn Gly Glu Thr Pro Ser Ser Leu Tyr Arg Val Ala Ala Val 
            260                 265                 270         


Leu Leu Gln Phe Asn Leu Ile Asp Leu Asp Asp Leu Tyr Val His Leu 
        275                 280                 285             


Leu Pro Ala Asp Asn Cys Ile Met Asp Glu His Lys Arg Glu Ile Ala 
    290                 295                 300                 


Glu Ala Lys Gln Ile Val Arg Lys Leu Thr Met Val Val Leu Ser Ser 
305                 310                 315                 320 


Glu Lys Met Asp Glu Arg Glu Lys Glu Lys Glu Lys Glu Glu Glu Lys 
                325                 330                 335     


Val Glu Lys Pro Pro Asp Asn Gln Lys Leu Gly Leu Leu Glu Ala Leu 
            340                 345                 350         


Leu Lys Ile Gly Asp Trp Gln His Ala Gln Asn Ile Met Asp Gln Met 
        355                 360                 365             


Pro Pro Tyr Tyr Ala Ala Ser His Lys Leu Ile Ala Leu Ala Ile Cys 
    370                 375                 380                 


Lys Leu Ile His Ile Thr Ile Glu Pro Leu Tyr Arg Arg Val Gly Val 
385                 390                 395                 400 


Pro Lys Gly Ala Lys Gly Ser Pro Val Asn Ala Leu Gln Asn Lys Arg 
                405                 410                 415     


Ala Pro Lys Gln Ala Glu Ser Phe Glu Asp Leu Arg Arg Asp Val Phe 
            420                 425                 430         


Asn Met Phe Cys Tyr Leu Gly Pro His Leu Ser His Asp Pro Ile Leu 
        435                 440                 445             


Phe Ala Lys Val Val Arg Ile Gly Lys Ser Phe Met Lys Glu Phe Gln 
    450                 455                 460                 


Ser Asp Gly Ser Lys Gln Glu Asp Lys Glu Lys Thr Glu Val Ile Leu 
465                 470                 475                 480 


Ser Cys Leu Leu Ser Ile Thr Asp Gln Val Leu Leu Pro Ser Leu Ser 
                485                 490                 495     


Leu Met Asp Cys Asn Ala Cys Met Ser Glu Glu Leu Trp Gly Met Phe 
            500                 505                 510         


Lys Thr Phe Pro Tyr Gln His Arg Tyr Arg Leu Tyr Gly Gln Trp Lys 
        515                 520                 525             


Asn Glu Thr Tyr Asn Ser His Pro Leu Leu Val Lys Val Lys Ala Gln 
    530                 535                 540                 


Thr Ile Asp Arg Ala Lys Tyr Ile Met Lys Arg Leu Thr Lys Glu Asn 
545                 550                 555                 560 


Val Lys Pro Ser Gly Arg Gln Ile Gly Lys Leu Ser His Ser Asn Pro 
                565                 570                 575     


Thr Ile Leu Phe Asp Tyr Ile Leu Ser Gln Ile Gln Lys Tyr Asp Asn 
            580                 585                 590         


Leu Ile Thr Pro Val Val Asp Ser Leu Lys Tyr Leu Thr Ser Leu Asn 
        595                 600                 605             


Tyr Asp Val Leu Ala Tyr Cys Ile Ile Glu Ala Leu Ala Asn Pro Glu 
    610                 615                 620                 


Lys Glu Arg Met Lys His Asp Asp Thr Thr Ile Ser Ser Trp Leu Gln 
625                 630                 635                 640 


Ser Leu Ala Ser Phe Cys Gly Ala Val Phe Arg Lys Tyr Pro Ile Asp 
                645                 650                 655     


Leu Ala Gly Leu Leu Gln Tyr Val Ala Asn Gln Leu Lys Ala Gly Lys 
            660                 665                 670         


Ser Phe Asp Leu Leu Ile Leu Lys Glu Val Val Gln Lys Met Ala Gly 
        675                 680                 685             


Ile Glu Ile Thr Glu Glu Met Thr Met Glu Gln Leu Glu Ala Met Thr 
    690                 695                 700                 


Gly Gly Glu Gln Leu Lys Ala Glu Gly Gly Tyr Phe Gly Gln Ile Arg 
705                 710                 715                 720 


Asn Thr Lys Lys Ser Ser Gln Arg Leu Lys Asp Ala Leu Leu Asp His 
                725                 730                 735     


Asp Leu Ala Leu Pro Leu Cys Leu Leu Met Ala Gln Gln Arg Asn Gly 
            740                 745                 750         


Val Ile Phe Gln Glu Gly Gly Glu Lys His Leu Lys Leu Val Gly Lys 
        755                 760                 765             


Leu Tyr Asp Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe Leu 
    770                 775                 780                 


Ala Ser Asn Leu Ser Thr Glu Asp Tyr Ile Lys Arg Val Pro Ser Ile 
785                 790                 795                 800 


Asp Val Leu Cys Asn Glu Phe His Thr Pro His Asp Ala Ala Phe Phe 
                805                 810                 815     


Leu Ser Arg Pro Met Tyr Ala His His Ile Ser Ser Lys Tyr Asp Glu 
            820                 825                 830         


Leu Lys Lys Ser Glu Lys Gly Ser Lys Gln Gln His Lys Val His Lys 
        835                 840                 845             


Tyr Ile Thr Ser Cys Glu Met Val Met Ala Pro Val His Glu Ala Val 
    850                 855                 860                 


Val Ser Leu His Val Ser Lys Val Trp Asp Asp Ile Ser Pro Gln Phe 
865                 870                 875                 880 


Tyr Ala Thr Phe Trp Ser Leu Thr Met Tyr Asp Leu Ala Val Pro His 
                885                 890                 895     


Thr Ser Tyr Glu Arg Glu Val Asn Lys Leu Lys Val Gln Met Lys Ala 
            900                 905                 910         


Ile Asp Asp Asn Gln Glu Met Pro Pro Asn Lys Lys Lys Lys Glu Lys 
        915                 920                 925             


Glu Arg Cys Thr Ala Leu Gln Asp Lys Leu Leu Glu Glu Glu Lys Lys 
    930                 935                 940                 


Gln Met Glu His Val Gln Arg Val Leu Gln Arg Leu Lys Leu Glu Lys 
945                 950                 955                 960 


Asp Asn Trp Leu Leu Ala Lys Ser Thr Lys Asn Glu Thr Ile Thr Lys 
                965                 970                 975     


Phe Leu Gln Leu Cys Ile Phe Pro Arg Cys Ile Phe Ser Ala Ile Asp 
            980                 985                 990         


Ala Val Tyr Cys Ala Arg Phe Val  Glu Leu Val His Gln  Gln Lys Thr 
        995                 1000                 1005             


Pro Asn  Phe Ser Thr Leu Leu  Cys Tyr Asp Arg Val  Phe Ser Asp 
    1010                 1015                 1020             


Ile Ile  Tyr Thr Val Ala Ser  Cys Thr Glu Asn Glu  Ala Ser Arg 
    1025                 1030                 1035             


Tyr Gly  Arg Phe Leu Cys Cys  Met Leu Glu Thr Val  Thr Arg Trp 
    1040                 1045                 1050             


His Ser  Asp Arg Ala Thr Tyr  Glu Lys Glu Cys Gly  Asn Tyr Pro 
    1055                 1060                 1065             


Gly Phe  Leu Thr Ile Leu Arg  Ala Thr Gly Phe Asp  Gly Gly Asn 
    1070                 1075                 1080             


Lys Ala  Asp Gln Leu Asp Tyr  Glu Asn Phe Arg His  Val Val His 
    1085                 1090                 1095             


Lys Trp  His Tyr Lys Leu Thr  Lys Ala Ser Val His  Cys Leu Glu 
    1100                 1105                 1110             


Thr Gly  Glu Tyr Thr His Ile  Arg Asn Ile Leu Ile  Val Leu Thr 
    1115                 1120                 1125             


Lys Ile  Leu Pro Trp Tyr Pro  Lys Val Leu Asn Leu  Gly Gln Ala 
    1130                 1135                 1140             


Leu Glu  Arg Arg Val His Lys  Ile Cys Gln Glu Glu  Lys Glu Lys 
    1145                 1150                 1155             


Arg Pro  Asp Leu Tyr Ala Leu  Ala Met Gly Tyr Ser  Gly Gln Leu 
    1160                 1165                 1170             


Lys Ser  Arg Lys Ser Tyr Met  Ile Pro Glu Asn Glu  Phe His His 
    1175                 1180                 1185             


Lys Asp  Pro Pro Pro Arg Asn  Ala Val Ala Ser Val  Gln Asn Gly 
    1190                 1195                 1200             


Pro Gly  Gly Gly Pro Ser Ser  Ser Ser Ile Gly Ser  Ala Ser Lys 
    1205                 1210                 1215             


Ser Asp  Glu Ser Ser Thr Glu  Glu Thr Asp Lys Ser  Arg Glu Arg 
    1220                 1225                 1230             


Ser Gln  Cys Gly Val Lys Ala  Val Asn Lys Ala Ser  Ser Thr Thr 
    1235                 1240                 1245             


Pro Lys  Gly Asn Ser Ser Asn  Gly Asn Ser Gly Ser  Asn Ser Asn 
    1250                 1255                 1260             


Lys Ala  Val Lys Glu Asn Asp  Lys Glu Lys Gly Lys  Glu Lys Glu 
    1265                 1270                 1275             


Lys Glu  Lys Lys Glu Lys Thr  Pro Ala Thr Thr Pro  Glu Ala Arg 
    1280                 1285                 1290             


Val Leu  Gly Lys Asp Gly Lys  Glu Lys Pro Lys Glu  Glu Arg Pro 
    1295                 1300                 1305             


Asn Lys  Asp Glu Lys Ala Arg  Glu Thr Lys Glu Arg  Thr Pro Lys 
    1310                 1315                 1320             


Ser Asp  Lys Glu Lys Glu Lys  Phe Lys Lys Glu Glu  Lys Ala Lys 
    1325                 1330                 1335             


Asp Glu  Lys Phe Lys Thr Thr  Val Pro Asn Ala Glu  Ser Lys Ser 
    1340                 1345                 1350             


Thr Gln  Glu Arg Glu Arg Glu  Lys Glu Pro Ser Arg  Glu Arg Asp 
    1355                 1360                 1365             


Ile Ala  Lys Glu Met Lys Ser  Lys Glu Asn Val Lys  Gly Gly Glu 
    1370                 1375                 1380             


Lys Thr  Pro Val Ser Gly Ser  Leu Lys Ser Pro Val  Pro Arg Ser 
    1385                 1390                 1395             


Asp Ile  Pro Glu Pro Glu Arg  Glu Gln Lys Arg Arg  Lys Ile Asp 
    1400                 1405                 1410             


Thr His  Pro Ser Pro Ser His  Ser Ser Thr Val Lys  Asp Ser Leu 
    1415                 1420                 1425             


Ile Glu  Leu Lys Glu Ser Ser  Ala Lys Leu Tyr Ile  Asn His Thr 
    1430                 1435                 1440             


Pro Pro  Pro Leu Ser Lys Ser  Lys Glu Arg Glu Met  Asp Lys Lys 
    1445                 1450                 1455             


Asp Leu  Asp Lys Ser Arg Glu  Arg Ser Arg Glu Arg  Glu Lys Lys 
    1460                 1465                 1470             


Asp Glu  Lys Asp Arg Lys Glu  Arg Lys Arg Asp His  Ser Asn Asn 
    1475                 1480                 1485             


Asp Arg  Glu Val Pro Pro Asp  Leu Thr Lys Arg Arg  Lys Glu Glu 
    1490                 1495                 1500             


Asn Gly  Thr Met Gly Val Ser  Lys His Lys Ser Glu  Ser Pro Cys 
    1505                 1510                 1515             


Glu Ser  Pro Tyr Pro Asn Glu  Lys Asp Lys Glu Lys  Asn Lys Ser 
    1520                 1525                 1530             


Lys Ser  Ser Gly Lys Glu Lys  Gly Ser Asp Ser Phe  Lys Ser Glu 
    1535                 1540                 1545             


Lys Met  Asp Lys Ile Ser Ser  Gly Gly Lys Lys Glu  Ser Arg His 
    1550                 1555                 1560             


Asp Lys  Glu Lys Ile Glu Lys  Lys Glu Lys Arg Asp  Ser Ser Gly 
    1565                 1570                 1575             


Gly Lys  Glu Glu Lys Lys His  His Lys Ser Ser Asp  Lys His Arg 
    1580                 1585                 1590             


<210>  1556
<211>  375
<212>  PRT
<213>  homo sapiens

<400>  1556

Met Glu Asp Glu Met Pro Lys Thr Leu Tyr Val Gly Asn Leu Ser Arg 
1               5                   10                  15      


Asp Val Thr Glu Ala Leu Ile Leu Gln Leu Phe Ser Gln Ile Gly Pro 
            20                  25                  30          


Cys Lys Asn Cys Lys Met Ile Met Asp Thr Ala Gly Asn Asp Pro Tyr 
        35                  40                  45              


Cys Phe Val Glu Phe His Glu His Arg His Ala Ala Ala Ala Leu Ala 
    50                  55                  60                  


Ala Met Asn Gly Arg Lys Ile Met Gly Lys Glu Val Lys Val Asn Trp 
65                  70                  75                  80  


Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Asn His Phe His 
                85                  90                  95      


Val Phe Val Gly Asp Leu Ser Pro Glu Ile Thr Thr Glu Asp Ile Lys 
            100                 105                 110         


Ala Ala Phe Ala Pro Phe Gly Arg Ile Ser Asp Ala Arg Val Val Lys 
        115                 120                 125             


Asp Met Ala Thr Gly Lys Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe 
    130                 135                 140                 


Asn Lys Trp Asp Ala Glu Asn Ala Ile Gln Gln Met Gly Gly Gln Trp 
145                 150                 155                 160 


Leu Gly Gly Arg Gln Ile Arg Thr Asn Trp Ala Thr Arg Lys Pro Pro 
                165                 170                 175     


Ala Pro Lys Ser Thr Tyr Glu Ser Asn Thr Lys Gln Leu Ser Tyr Asp 
            180                 185                 190         


Glu Val Val Asn Gln Ser Ser Pro Ser Asn Cys Thr Val Tyr Cys Gly 
        195                 200                 205             


Gly Val Thr Ser Gly Leu Thr Glu Gln Leu Met Arg Gln Thr Phe Ser 
    210                 215                 220                 


Pro Phe Gly Gln Ile Met Glu Ile Arg Val Phe Pro Asp Lys Gly Tyr 
225                 230                 235                 240 


Ser Phe Val Arg Phe Asn Ser His Glu Ser Ala Ala His Ala Ile Val 
                245                 250                 255     


Ser Val Asn Gly Thr Thr Ile Glu Gly His Val Val Lys Cys Tyr Trp 
            260                 265                 270         


Gly Lys Glu Thr Leu Asp Met Ile Asn Pro Val Gln Gln Gln Asn Gln 
        275                 280                 285             


Ile Gly Tyr Pro Gln Pro Tyr Gly Gln Trp Gly Gln Trp Tyr Gly Asn 
    290                 295                 300                 


Ala Gln Gln Ile Gly Gln Tyr Met Pro Asn Gly Trp Gln Val Pro Ala 
305                 310                 315                 320 


Tyr Gly Met Tyr Gly Gln Ala Trp Asn Gln Gln Gly Phe Asn Gln Thr 
                325                 330                 335     


Gln Ser Ser Ala Pro Trp Met Gly Pro Asn Tyr Gly Val Gln Pro Pro 
            340                 345                 350         


Gln Gly Gln Asn Gly Ser Met Leu Pro Asn Gln Pro Ser Gly Tyr Arg 
        355                 360                 365             


Val Ala Gly Tyr Glu Thr Gln 
    370                 375 


<210>  1557
<211>  766
<212>  PRT
<213>  homo sapiens

<400>  1557

Met Ser Val Gln Ser Ser Ser Gly Ser Leu Glu Gly Pro Pro Ser Trp 
1               5                   10                  15      


Ser Gln Leu Ser Thr Ser Pro Thr Pro Gly Ser Ala Ala Ala Ala Arg 
            20                  25                  30          


Ser Leu Leu Asn His Thr Pro Pro Ser Gly Arg Pro Arg Glu Gly Ala 
        35                  40                  45              


Met Asp Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu Glu 
    50                  55                  60                  


Ala Arg Phe Thr Gly Val Ala Ser Gly Ser Thr Gly Ser Thr Gly Ser 
65                  70                  75                  80  


Cys Ser Val Gly Ala Lys Ala Ser Thr Asn Asn Glu Ser Ser Asn His 
                85                  90                  95      


Ser Phe Gly Ser Leu Gly Ser Leu Ser Asp Lys Glu Ser Glu Thr Pro 
            100                 105                 110         


Glu Lys Lys Gln Ser Glu Ser Ser Arg Gly Arg Lys Arg Lys Ala Glu 
        115                 120                 125             


Asn Gln Asn Glu Ser Ser Gln Gly Lys Ser Ile Gly Gly Arg Gly His 
    130                 135                 140                 


Lys Ile Ser Asp Tyr Phe Glu Tyr Gln Gly Gly Asn Gly Ser Ser Pro 
145                 150                 155                 160 


Val Arg Gly Ile Pro Pro Ala Ile Arg Ser Pro Gln Asn Ser His Ser 
                165                 170                 175     


His Ser Thr Pro Ser Ser Ser Val Arg Pro Asn Ser Pro Ser Pro Thr 
            180                 185                 190         


Ala Leu Ala Phe Gly Asp His Pro Ile Val Gln Pro Lys Gln Leu Ser 
        195                 200                 205             


Phe Lys Ile Ile Gln Thr Asp Leu Thr Met Leu Lys Leu Ala Ala Leu 
    210                 215                 220                 


Glu Ser Asn Lys Ile Gln Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp 
225                 230                 235                 240 


Asp Leu Leu Arg Ala Asn Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln 
                245                 250                 255     


Gln Lys Leu Leu Glu Lys Tyr Lys Glu Arg Leu Asn Lys Cys Ile Ser 
            260                 265                 270         


Met Ser Lys Lys Leu Leu Ile Glu Lys Ser Thr Gln Glu Lys Leu Ser 
        275                 280                 285             


Ser Arg Glu Lys Ser Met Gln Asp Arg Leu Arg Leu Gly His Phe Thr 
    290                 295                 300                 


Thr Val Arg His Gly Ala Ser Phe Thr Glu Gln Trp Thr Asp Gly Phe 
305                 310                 315                 320 


Ala Phe Gln Asn Leu Val Lys Gln Gln Glu Trp Val Asn Gln Gln Arg 
                325                 330                 335     


Glu Asp Ile Glu Arg Gln Arg Lys Leu Leu Ala Lys Arg Lys Pro Pro 
            340                 345                 350         


Thr Ala Asn Asn Ser Gln Ala Pro Ser Thr Asn Ser Glu Pro Lys Gln 
        355                 360                 365             


Arg Lys Asn Lys Ala Val Asn Gly Ala Glu Asn Asp Pro Phe Val Arg 
    370                 375                 380                 


Pro Asn Leu Pro Gln Leu Leu Thr Leu Ala Glu Tyr His Glu Gln Glu 
385                 390                 395                 400 


Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys Lys Glu Glu Ala Glu 
                405                 410                 415     


Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val Arg Asn Leu His Ile 
            420                 425                 430         


Arg Glu Leu Lys Arg Ile Asn Asn Glu Asp Asn Ser Gln Phe Lys Asp 
        435                 440                 445             


His Pro Thr Leu Asn Glu Arg Tyr Leu Leu Leu His Leu Leu Gly Arg 
    450                 455                 460                 


Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp Leu Tyr Glu Gln Arg 
465                 470                 475                 480 


Tyr Ala Ala Val Lys Ile His Gln Leu Asn Lys Ser Trp Arg Asp Glu 
                485                 490                 495     


Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg Glu Tyr Arg Ile His 
            500                 505                 510         


Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu Tyr Asp Tyr Phe Ser 
        515                 520                 525             


Leu Asp Thr Asp Thr Phe Cys Thr Val Leu Glu Tyr Cys Glu Gly Asn 
    530                 535                 540                 


Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu Met Ser Glu Lys Glu 
545                 550                 555                 560 


Ala Arg Ser Ile Val Met Gln Ile Val Asn Ala Leu Arg Tyr Leu Asn 
                565                 570                 575     


Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu Lys Pro Gly Asn Ile 
            580                 585                 590         


Leu Leu Val Asp Gly Thr Ala Cys Gly Glu Ile Lys Ile Thr Asp Phe 
        595                 600                 605             


Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr Gly Val Asp Gly Met 
    610                 615                 620                 


Asp Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp Tyr Leu Pro Pro Glu 
625                 630                 635                 640 


Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile Ser Asn Lys Val Asp 
                645                 650                 655     


Val Trp Ser Val Gly Val Ile Phe Phe Gln Cys Leu Tyr Gly Arg Lys 
            660                 665                 670         


Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile Leu Gln Glu Asn Thr 
        675                 680                 685             


Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Val Lys Pro Val Val Ser 
    690                 695                 700                 


Ser Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu Ala Tyr Arg Lys Glu 
705                 710                 715                 720 


Asp Arg Phe Asp Val His Gln Leu Ala Asn Asp Pro Tyr Leu Leu Pro 
                725                 730                 735     


His Met Arg Arg Ser Asn Ser Ser Gly Asn Leu His Met Ala Gly Leu 
            740                 745                 750         


Thr Ala Ser Pro Thr Pro Pro Ser Ser Ser Ile Ile Thr Tyr 
        755                 760                 765     


<210>  1558
<211>  555
<212>  PRT
<213>  homo sapiens

<400>  1558

Met Ala Ala Ala Ala Trp Leu Gln Val Leu Pro Val Ile Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ala His Pro Ser Pro Leu Ser Phe Phe Ser Ala Gly Pro Ala 
            20                  25                  30          


Thr Val Ala Ala Ala Asp Arg Ser Lys Trp His Ile Pro Ile Pro Ser 
        35                  40                  45              


Gly Lys Asn Tyr Phe Ser Phe Gly Lys Ile Leu Phe Arg Asn Thr Thr 
    50                  55                  60                  


Ile Phe Leu Lys Phe Asp Gly Glu Pro Cys Asp Leu Ser Leu Asn Ile 
65                  70                  75                  80  


Thr Trp Tyr Leu Lys Ser Ala Asp Cys Tyr Asn Glu Ile Tyr Asn Phe 
                85                  90                  95      


Lys Ala Glu Glu Val Glu Leu Tyr Leu Glu Lys Leu Lys Glu Lys Arg 
            100                 105                 110         


Gly Leu Ser Gly Lys Tyr Gln Thr Ser Ser Lys Leu Phe Gln Asn Cys 
        115                 120                 125             


Ser Glu Leu Phe Lys Thr Gln Thr Phe Ser Gly Asp Phe Met His Arg 
    130                 135                 140                 


Leu Pro Leu Leu Gly Glu Lys Gln Glu Ala Lys Glu Asn Gly Thr Asn 
145                 150                 155                 160 


Leu Thr Phe Ile Gly Asp Lys Thr Ala Met His Glu Pro Leu Gln Thr 
                165                 170                 175     


Trp Gln Asp Ala Pro Tyr Ile Phe Ile Val His Ile Gly Ile Ser Ser 
            180                 185                 190         


Ser Lys Glu Ser Ser Lys Glu Asn Ser Leu Ser Asn Leu Phe Thr Met 
        195                 200                 205             


Thr Val Glu Val Lys Gly Pro Tyr Glu Tyr Leu Thr Leu Glu Asp Tyr 
    210                 215                 220                 


Pro Leu Met Ile Phe Phe Met Val Met Cys Ile Val Tyr Val Leu Phe 
225                 230                 235                 240 


Gly Val Leu Trp Leu Ala Trp Ser Ala Cys Tyr Trp Arg Asp Leu Leu 
                245                 250                 255     


Arg Ile Gln Phe Trp Ile Gly Ala Val Ile Phe Leu Gly Met Leu Glu 
            260                 265                 270         


Lys Ala Val Phe Tyr Ala Glu Phe Gln Asn Ile Arg Tyr Lys Gly Glu 
        275                 280                 285             


Ser Val Gln Gly Ala Leu Ile Leu Ala Glu Leu Leu Ser Ala Val Lys 
    290                 295                 300                 


Arg Ser Leu Ala Arg Thr Leu Val Ile Ile Val Ser Leu Gly Tyr Gly 
305                 310                 315                 320 


Ile Val Lys Pro Arg Leu Gly Val Thr Leu His Lys Val Val Val Ala 
                325                 330                 335     


Gly Ala Leu Tyr Leu Leu Phe Ser Gly Met Glu Gly Val Leu Arg Val 
            340                 345                 350         


Thr Gly Ala Gln Thr Asp Leu Ala Ser Leu Ala Phe Ile Pro Leu Ala 
        355                 360                 365             


Phe Leu Asp Thr Ala Leu Cys Trp Trp Ile Phe Ile Ser Leu Thr Gln 
    370                 375                 380                 


Thr Met Lys Leu Leu Lys Leu Arg Arg Asn Ile Val Lys Leu Ser Leu 
385                 390                 395                 400 


Tyr Arg His Phe Thr Asn Thr Leu Ile Leu Ala Val Ala Ala Ser Ile 
                405                 410                 415     


Val Phe Ile Ile Trp Thr Thr Met Lys Phe Arg Ile Val Thr Cys Gln 
            420                 425                 430         


Ser Asp Trp Arg Glu Leu Trp Val Asp Asp Ala Ile Trp Arg Leu Leu 
        435                 440                 445             


Phe Ser Met Ile Leu Phe Val Ile Met Val Leu Trp Arg Pro Ser Ala 
    450                 455                 460                 


Asn Asn Gln Arg Phe Ala Phe Ser Pro Leu Ser Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Gln Lys Glu Pro Met Leu Lys Glu Ser Phe Glu Gly Met Lys 
                485                 490                 495     


Met Arg Ser Thr Lys Gln Glu Pro Asn Gly Asn Ser Lys Val Asn Lys 
            500                 505                 510         


Ala Gln Glu Asp Asp Leu Lys Trp Val Glu Glu Asn Val Pro Ser Ser 
        515                 520                 525             


Val Thr Asp Val Ala Leu Pro Ala Leu Leu Asp Ser Asp Glu Glu Arg 
    530                 535                 540                 


Met Ile Thr His Phe Glu Arg Ser Lys Met Glu 
545                 550                 555 


<210>  1559
<211>  234
<212>  PRT
<213>  homo sapiens

<400>  1559

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  1560
<211>  140
<212>  PRT
<213>  homo sapiens

<400>  1560

Met Ser Gly Ser Phe Tyr Phe Val Ile Val Gly His His Asp Asn Pro 
1               5                   10                  15      


Val Phe Glu Met Glu Phe Leu Pro Ala Gly Lys Ala Glu Ser Lys Asp 
            20                  25                  30          


Asp His Arg His Leu Asn Gln Phe Ile Ala His Ala Ala Leu Asp Leu 
        35                  40                  45              


Val Asp Glu Asn Met Trp Leu Ser Asn Asn Met Tyr Leu Lys Thr Val 
    50                  55                  60                  


Asp Lys Phe Asn Glu Trp Phe Val Ser Ala Phe Val Thr Ala Gly His 
65                  70                  75                  80  


Met Arg Phe Ile Met Leu His Asp Ile Arg Gln Glu Asp Gly Ile Lys 
                85                  90                  95      


Asn Phe Phe Thr Asp Val Tyr Asp Leu Tyr Ile Lys Phe Ser Met Asn 
            100                 105                 110         


Pro Phe Tyr Glu Pro Asn Ser Pro Ile Arg Ser Ser Ala Phe Asp Arg 
        115                 120                 125             


Lys Val Gln Phe Leu Gly Lys Lys His Leu Leu Ser 
    130                 135                 140 


<210>  1561
<211>  1979
<212>  PRT
<213>  homo sapiens

<400>  1561

Met Ser Ser Trp Leu Gly Gly Leu Gly Ser Gly Leu Gly Gln Ser Leu 
1               5                   10                  15      


Gly Gln Val Gly Gly Ser Leu Ala Ser Leu Thr Gly Gln Ile Ser Asn 
            20                  25                  30          


Phe Thr Lys Asp Met Leu Met Glu Gly Thr Glu Glu Val Glu Ala Glu 
        35                  40                  45              


Leu Pro Asp Ser Arg Thr Lys Glu Ile Glu Ala Ile His Ala Ile Leu 
    50                  55                  60                  


Arg Ser Glu Asn Glu Arg Leu Lys Lys Leu Cys Thr Asp Leu Glu Glu 
65                  70                  75                  80  


Lys His Glu Ala Ser Glu Ile Gln Ile Lys Gln Gln Ser Thr Ser Tyr 
                85                  90                  95      


Arg Asn Gln Leu Gln Gln Lys Glu Val Glu Ile Ser His Leu Lys Ala 
            100                 105                 110         


Arg Gln Ile Ala Leu Gln Asp Gln Leu Leu Lys Leu Gln Ser Ala Ala 
        115                 120                 125             


Gln Ser Val Pro Ser Gly Ala Gly Val Pro Ala Thr Thr Ala Ser Ser 
    130                 135                 140                 


Ser Phe Ala Tyr Gly Ile Ser His His Pro Ser Ala Phe His Asp Asp 
145                 150                 155                 160 


Asp Met Asp Phe Gly Asp Ile Ile Ser Ser Gln Gln Glu Ile Asn Arg 
                165                 170                 175     


Leu Ser Asn Glu Val Ser Arg Leu Glu Ser Glu Val Gly His Trp Arg 
            180                 185                 190         


His Ile Ala Gln Thr Ser Lys Ala Gln Gly Thr Asp Asn Ser Asp Gln 
        195                 200                 205             


Ser Glu Ile Cys Lys Leu Gln Asn Ile Ile Lys Glu Leu Lys Gln Asn 
    210                 215                 220                 


Arg Ser Gln Glu Ile Asp Asp His Gln His Glu Met Ser Val Leu Gln 
225                 230                 235                 240 


Asn Ala His Gln Gln Lys Leu Thr Glu Ile Ser Arg Arg His Arg Glu 
                245                 250                 255     


Glu Leu Ser Asp Tyr Glu Glu Arg Ile Glu Glu Leu Glu Asn Leu Leu 
            260                 265                 270         


Gln Gln Gly Gly Ser Gly Val Ile Glu Thr Asp Leu Ser Lys Ile Tyr 
        275                 280                 285             


Glu Met Gln Lys Thr Ile Gln Val Leu Gln Ile Glu Lys Val Glu Ser 
    290                 295                 300                 


Thr Lys Lys Met Glu Gln Leu Glu Asp Lys Ile Lys Asp Ile Asn Lys 
305                 310                 315                 320 


Lys Leu Ser Ser Ala Glu Asn Asp Arg Asp Ile Leu Arg Arg Glu Gln 
                325                 330                 335     


Glu Gln Leu Asn Val Glu Lys Arg Gln Ile Met Glu Glu Cys Glu Asn 
            340                 345                 350         


Leu Lys Leu Glu Cys Ser Lys Leu Gln Pro Ser Ala Val Lys Gln Ser 
        355                 360                 365             


Asp Thr Met Thr Glu Lys Glu Arg Ile Leu Ala Gln Ser Ala Ser Val 
    370                 375                 380                 


Glu Glu Val Phe Arg Leu Gln Gln Ala Leu Ser Asp Ala Glu Asn Glu 
385                 390                 395                 400 


Ile Met Arg Leu Ser Ser Leu Asn Gln Asp Asn Ser Leu Ala Glu Asp 
                405                 410                 415     


Asn Leu Lys Leu Lys Met Arg Ile Glu Val Leu Glu Lys Glu Lys Ser 
            420                 425                 430         


Leu Leu Ser Gln Glu Lys Glu Glu Leu Gln Met Ser Leu Leu Lys Leu 
        435                 440                 445             


Asn Asn Glu Tyr Glu Val Ile Lys Ser Thr Ala Thr Arg Asp Ile Ser 
    450                 455                 460                 


Leu Asp Ser Glu Leu His Asp Leu Arg Leu Asn Leu Glu Ala Lys Glu 
465                 470                 475                 480 


Gln Glu Leu Asn Gln Ser Ile Ser Glu Lys Glu Thr Leu Ile Ala Glu 
                485                 490                 495     


Ile Glu Glu Leu Asp Arg Gln Asn Gln Glu Ala Thr Lys His Met Ile 
            500                 505                 510         


Leu Ile Lys Asp Gln Leu Ser Lys Gln Gln Asn Glu Gly Asp Ser Ile 
        515                 520                 525             


Ile Ser Lys Leu Lys Gln Asp Leu Asn Asp Glu Lys Lys Arg Val His 
    530                 535                 540                 


Gln Leu Glu Asp Asp Lys Met Asp Ile Thr Lys Glu Leu Asp Val Gln 
545                 550                 555                 560 


Lys Glu Lys Leu Ile Gln Ser Glu Val Ala Leu Asn Asp Leu His Leu 
                565                 570                 575     


Thr Lys Gln Lys Leu Glu Asp Lys Val Glu Asn Leu Val Asp Gln Leu 
            580                 585                 590         


Asn Lys Ser Gln Glu Ser Asn Val Ser Ile Gln Lys Glu Asn Leu Glu 
        595                 600                 605             


Leu Lys Glu His Ile Arg Gln Asn Glu Glu Glu Leu Ser Arg Ile Arg 
    610                 615                 620                 


Asn Glu Leu Met Gln Ser Leu Asn Gln Asp Ser Asn Ser Asn Phe Lys 
625                 630                 635                 640 


Asp Thr Leu Leu Lys Glu Arg Glu Ala Glu Val Arg Asn Leu Lys Gln 
                645                 650                 655     


Asn Leu Ser Glu Leu Glu Gln Leu Asn Glu Asn Leu Lys Lys Val Ala 
            660                 665                 670         


Phe Asp Val Lys Met Glu Asn Glu Lys Leu Val Leu Ala Cys Glu Asp 
        675                 680                 685             


Val Arg His Gln Leu Glu Glu Cys Leu Ala Gly Asn Asn Gln Leu Ser 
    690                 695                 700                 


Leu Glu Lys Asn Thr Ile Val Glu Thr Leu Lys Met Glu Lys Gly Glu 
705                 710                 715                 720 


Ile Glu Ala Glu Leu Cys Trp Ala Lys Lys Arg Leu Leu Glu Glu Ala 
                725                 730                 735     


Asn Lys Tyr Glu Lys Thr Ile Glu Glu Leu Ser Asn Ala Arg Asn Leu 
            740                 745                 750         


Asn Thr Ser Ala Leu Gln Leu Glu His Glu His Leu Ile Lys Leu Asn 
        755                 760                 765             


Gln Lys Lys Asp Met Glu Ile Ala Glu Leu Lys Lys Asn Ile Glu Gln 
    770                 775                 780                 


Met Asp Thr Asp His Lys Glu Thr Lys Asp Val Leu Ser Ser Ser Leu 
785                 790                 795                 800 


Glu Glu Gln Lys Gln Leu Thr Gln Leu Ile Asn Lys Lys Glu Ile Phe 
                805                 810                 815     


Ile Glu Lys Leu Lys Glu Arg Ser Ser Lys Leu Gln Glu Glu Leu Asp 
            820                 825                 830         


Lys Tyr Ser Gln Ala Leu Arg Lys Asn Glu Ile Leu Arg Gln Thr Ile 
        835                 840                 845             


Glu Glu Lys Asp Arg Ser Leu Gly Ser Met Lys Glu Glu Asn Asn His 
    850                 855                 860                 


Leu Gln Glu Glu Leu Glu Arg Leu Arg Glu Glu Gln Ser Arg Thr Ala 
865                 870                 875                 880 


Pro Val Ala Asp Pro Lys Thr Leu Asp Ser Val Thr Glu Leu Ala Ser 
                885                 890                 895     


Glu Val Ser Gln Leu Asn Thr Ile Lys Glu His Leu Glu Glu Glu Ile 
            900                 905                 910         


Lys His His Gln Lys Ile Ile Glu Asp Gln Asn Gln Ser Lys Met Gln 
        915                 920                 925             


Leu Leu Gln Ser Leu Gln Glu Gln Lys Lys Glu Met Asp Glu Phe Arg 
    930                 935                 940                 


Tyr Gln His Glu Gln Met Asn Ala Thr His Thr Gln Leu Phe Leu Glu 
945                 950                 955                 960 


Lys Asp Glu Glu Ile Lys Ser Leu Gln Lys Thr Ile Glu Gln Ile Lys 
                965                 970                 975     


Thr Gln Leu His Glu Glu Arg Gln Asp Ile Gln Thr Asp Asn Ser Asp 
            980                 985                 990         


Ile Phe Gln Glu Thr Lys Val Gln  Ser Leu Asn Ile Glu  Asn Gly Ser 
        995                 1000                 1005             


Glu Lys  His Asp Leu Ser Lys  Ala Glu Thr Glu Arg  Leu Val Lys 
    1010                 1015                 1020             


Gly Ile  Lys Glu Arg Glu Leu  Glu Ile Lys Leu Leu  Asn Glu Lys 
    1025                 1030                 1035             


Asn Ile  Ser Leu Thr Lys Gln  Ile Asp Gln Leu Ser  Lys Asp Glu 
    1040                 1045                 1050             


Val Gly  Lys Leu Thr Gln Ile  Ile Gln Gln Lys Asp  Leu Glu Ile 
    1055                 1060                 1065             


Gln Ala  Leu His Ala Arg Ile  Ser Ser Thr Ser His  Thr Gln Asp 
    1070                 1075                 1080             


Val Val  Tyr Leu Gln Gln Gln  Leu Gln Ala Tyr Ala  Met Glu Arg 
    1085                 1090                 1095             


Glu Lys  Val Phe Ala Val Leu  Asn Glu Lys Thr Arg  Glu Asn Ser 
    1100                 1105                 1110             


His Leu  Lys Thr Glu Tyr His  Lys Met Met Asp Ile  Val Ala Ala 
    1115                 1120                 1125             


Lys Glu  Ala Ala Leu Ile Lys  Leu Gln Asp Glu Asn  Lys Lys Leu 
    1130                 1135                 1140             


Ser Thr  Arg Phe Glu Ser Ser  Gly Gln Asp Met Phe  Arg Glu Thr 
    1145                 1150                 1155             


Ile Gln  Asn Leu Ser Arg Ile  Ile Arg Glu Lys Asp  Ile Glu Ile 
    1160                 1165                 1170             


Asp Ala  Leu Ser Gln Lys Cys  Gln Thr Leu Leu Ala  Val Leu Gln 
    1175                 1180                 1185             


Thr Ser  Ser Thr Gly Asn Glu  Ala Gly Gly Val Asn  Ser Asn Gln 
    1190                 1195                 1200             


Phe Glu  Glu Leu Leu Gln Glu  Arg Asp Lys Leu Lys  Gln Gln Val 
    1205                 1210                 1215             


Lys Lys  Met Glu Glu Trp Lys  Gln Gln Val Met Thr  Thr Val Gln 
    1220                 1225                 1230             


Asn Met  Gln His Glu Ser Ala  Gln Leu Gln Glu Glu  Leu His Gln 
    1235                 1240                 1245             


Leu Gln  Ala Gln Val Leu Val  Asp Ser Asp Asn Asn  Ser Lys Leu 
    1250                 1255                 1260             


Gln Val  Asp Tyr Thr Gly Leu  Ile Gln Ser Tyr Glu  Gln Asn Glu 
    1265                 1270                 1275             


Thr Lys  Leu Lys Asn Phe Gly  Gln Glu Leu Ala Gln  Val Gln His 
    1280                 1285                 1290             


Ser Ile  Gly Gln Leu Cys Asn  Thr Lys Asp Leu Leu  Leu Gly Lys 
    1295                 1300                 1305             


Leu Asp  Ile Ile Ser Pro Gln  Leu Ser Ser Ala Ser  Leu Leu Thr 
    1310                 1315                 1320             


Pro Gln  Ser Ala Glu Cys Leu  Arg Ala Ser Lys Ser  Glu Val Leu 
    1325                 1330                 1335             


Ser Glu  Ser Ser Glu Leu Leu  Gln Gln Glu Leu Glu  Glu Leu Arg 
    1340                 1345                 1350             


Lys Ser  Leu Gln Glu Lys Asp  Ala Thr Ile Arg Thr  Leu Gln Glu 
    1355                 1360                 1365             


Asn Asn  His Arg Leu Ser Asp  Ser Ile Ala Ala Thr  Ser Glu Leu 
    1370                 1375                 1380             


Glu Arg  Lys Glu His Glu Gln  Thr Asp Ser Glu Ile  Lys Gln Leu 
    1385                 1390                 1395             


Lys Glu  Lys Gln Asp Val Leu  Gln Lys Leu Leu Lys  Glu Lys Asp 
    1400                 1405                 1410             


Leu Leu  Ile Lys Ala Lys Ser  Asp Gln Leu Leu Ser  Ser Asn Glu 
    1415                 1420                 1425             


Asn Phe  Thr Asn Lys Val Asn  Glu Asn Glu Leu Leu  Arg Gln Ala 
    1430                 1435                 1440             


Val Thr  Asn Leu Lys Glu Arg  Ile Leu Ile Leu Glu  Met Asp Ile 
    1445                 1450                 1455             


Gly Lys  Leu Lys Gly Glu Asn  Glu Lys Ile Val Glu  Thr Tyr Arg 
    1460                 1465                 1470             


Gly Lys  Glu Thr Glu Tyr Gln  Ala Leu Gln Glu Thr  Asn Met Lys 
    1475                 1480                 1485             


Phe Ser  Met Met Leu Arg Glu  Lys Glu Phe Glu Cys  His Ser Met 
    1490                 1495                 1500             


Lys Glu  Lys Ala Leu Ala Phe  Glu Gln Leu Leu Lys  Glu Lys Glu 
    1505                 1510                 1515             


Gln Gly  Lys Thr Gly Glu Leu  Asn Gln Leu Leu Asn  Ala Val Lys 
    1520                 1525                 1530             


Ser Met  Gln Glu Lys Thr Val  Val Phe Gln Gln Glu  Arg Asp Gln 
    1535                 1540                 1545             


Val Met  Leu Ala Leu Lys Gln  Lys Gln Met Glu Asn  Thr Ala Leu 
    1550                 1555                 1560             


Gln Asn  Glu Val Gln Arg Leu  Arg Asp Lys Glu Phe  Arg Ser Asn 
    1565                 1570                 1575             


Gln Glu  Leu Glu Arg Leu Arg  Asn His Leu Leu Glu  Ser Glu Asp 
    1580                 1585                 1590             


Ser Tyr  Thr Arg Glu Ala Leu  Ala Ala Glu Asp Arg  Glu Ala Lys 
    1595                 1600                 1605             


Leu Arg  Lys Lys Val Thr Val  Leu Glu Glu Lys Leu  Val Ser Ser 
    1610                 1615                 1620             


Ser Asn  Ala Met Glu Asn Ala  Ser His Gln Ala Ser  Val Gln Val 
    1625                 1630                 1635             


Glu Ser  Leu Gln Glu Gln Leu  Asn Val Val Ser Lys  Gln Arg Asp 
    1640                 1645                 1650             


Glu Thr  Ala Leu Gln Leu Ser  Val Ser Gln Glu Gln  Val Lys Gln 
    1655                 1660                 1665             


Tyr Ala  Leu Ser Leu Ala Asn  Leu Gln Met Val Leu  Glu His Phe 
    1670                 1675                 1680             


Gln Gln  Glu Glu Lys Ala Met  Tyr Ser Ala Glu Leu  Glu Lys Gln 
    1685                 1690                 1695             


Lys Gln  Leu Ile Ala Glu Trp  Lys Lys Asn Ala Glu  Asn Leu Glu 
    1700                 1705                 1710             


Gly Lys  Val Ile Ser Leu Gln  Glu Cys Leu Asp Glu  Ala Asn Ala 
    1715                 1720                 1725             


Ala Leu  Asp Ser Ala Ser Arg  Leu Thr Glu Gln Leu  Asp Val Lys 
    1730                 1735                 1740             


Glu Glu  Gln Ile Glu Glu Leu  Lys Arg Gln Asn Glu  Leu Arg Gln 
    1745                 1750                 1755             


Glu Met  Leu Asp Asp Val Gln  Lys Lys Leu Met Ser  Leu Ala Asn 
    1760                 1765                 1770             


Ser Ser  Glu Gly Lys Val Asp  Lys Val Leu Met Arg  Asn Leu Phe 
    1775                 1780                 1785             


Ile Gly  His Phe His Thr Pro  Lys Asn Gln Arg His  Glu Val Leu 
    1790                 1795                 1800             


Arg Leu  Met Gly Ser Ile Leu  Gly Val Arg Arg Glu  Glu Met Glu 
    1805                 1810                 1815             


Gln Leu  Phe His Asp Asp Gln  Gly Gly Val Thr Arg  Trp Met Thr 
    1820                 1825                 1830             


Gly Trp  Leu Gly Gly Gly Ser  Lys Ser Val Pro Asn  Thr Pro Leu 
    1835                 1840                 1845             


Arg Pro  Asn Gln Gln Ser Val  Val Asn Ser Ser Phe  Ser Glu Leu 
    1850                 1855                 1860             


Phe Val  Lys Phe Leu Glu Thr  Glu Ser His Pro Ser  Ile Pro Pro 
    1865                 1870                 1875             


Pro Lys  Leu Ser Val His Asp  Met Lys Pro Leu Asp  Ser Pro Gly 
    1880                 1885                 1890             


Arg Arg  Lys Arg Asp Thr Asn  Ala Pro Glu Ser Phe  Lys Asp Thr 
    1895                 1900                 1905             


Ala Glu  Ser Arg Ser Gly Arg  Arg Thr Asp Val Asn  Pro Phe Leu 
    1910                 1915                 1920             


Ala Pro  Arg Ser Ala Ala Val  Pro Leu Ile Asn Pro  Ala Gly Leu 
    1925                 1930                 1935             


Gly Pro  Gly Gly Pro Gly His  Leu Leu Leu Lys Pro  Ile Ser Asp 
    1940                 1945                 1950             


Val Leu  Pro Thr Phe Thr Pro  Leu Pro Ala Leu Pro  Asp Asn Ser 
    1955                 1960                 1965             


Ala Gly  Val Val Leu Lys Asp  Leu Leu Lys Gln 
    1970                 1975                 


<210>  1562
<211>  1141
<212>  PRT
<213>  homo sapiens

<400>  1562

Met Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys 
1               5                   10                  15      


Ser Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala 
            20                  25                  30          


Ala Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly 
        35                  40                  45              


Lys Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His 
    50                  55                  60                  


Asp Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn 
                85                  90                  95      


Glu Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro 
            100                 105                 110         


Asp Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp 
        115                 120                 125             


Gly Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr 
    130                 135                 140                 


Ile Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys 
145                 150                 155                 160 


Thr Lys Ile Leu Glu Leu Pro Tyr Ser Ile His Ala Phe Gln His Leu 
                165                 170                 175     


Arg Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys 
            180                 185                 190         


Glu Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile 
        195                 200                 205             


Asp Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser 
    210                 215                 220                 


Ser Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn 
225                 230                 235                 240 


Glu Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser 
                245                 250                 255     


Ser Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu 
            260                 265                 270         


His Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala 
        275                 280                 285             


Leu Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile 
    290                 295                 300                 


Tyr Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His 
305                 310                 315                 320 


Ala Leu Gln Ala Arg Pro Gly Phe Glu Gln Ala Ile Lys Arg Lys His 
                325                 330                 335     


Ala Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His 
            340                 345                 350         


Arg Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln 
        355                 360                 365             


His Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu 
    370                 375                 380                 


Ile Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met 
385                 390                 395                 400 


Ala Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn 
                405                 410                 415     


Gln Gln His Ser Leu His Cys Gln Trp Asp Gln Pro Val Arg Tyr His 
            420                 425                 430         


Arg Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp 
        435                 440                 445             


Ser Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn 
    450                 455                 460                 


Gln Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser 
465                 470                 475                 480 


Ile Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln 
                485                 490                 495     


His Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg 
            500                 505                 510         


Val Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn 
        515                 520                 525             


Lys Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu 
    530                 535                 540                 


Glu Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser 
545                 550                 555                 560 


His Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu 
                565                 570                 575     


Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg 
            580                 585                 590         


Ile Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe 
        595                 600                 605             


His Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu 
    610                 615                 620                 


Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala 
625                 630                 635                 640 


Cys Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val 
                645                 650                 655     


Pro Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu 
            660                 665                 670         


Asp Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu 
        675                 680                 685             


Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn 
    690                 695                 700                 


Ile Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr 
705                 710                 715                 720 


Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln 
                725                 730                 735     


Phe Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Thr 
            740                 745                 750         


Val Val Glu Glu Ser Asn Gly Ser Asp Glu Met Glu Asn Ser Asp Glu 
        755                 760                 765             


Thr Lys Met Ser Glu Glu Ile Leu Ala Leu Val Asp Glu Phe Gln Gln 
    770                 775                 780                 


Ala Trp Pro Leu Glu Gly Phe Gly Gly Ala Leu Glu Met Lys Gly Arg 
785                 790                 795                 800 


Arg Leu Asp Leu Gln Gly Ile Arg Val Leu Lys Lys Gly Pro Gln Asp 
                805                 810                 815     


Gly Val Ala Arg Ser Ser Cys Tyr Gly Asp Cys Arg Ser Glu Asp Asp 
            820                 825                 830         


Glu Ala Thr Glu Trp Ile Thr Phe Gln Val Lys Arg Val Lys Lys Pro 
        835                 840                 845             


Lys Gly Asp His Lys Lys Thr Pro Gly Lys Lys Val Glu Thr Gly Gln 
    850                 855                 860                 


Ile Glu Asn Gly His Arg Tyr Gln Ala Asn Leu Glu Ile Thr Gly Pro 
865                 870                 875                 880 


Lys Val Ala Ser Pro Gly Pro Gln Gly Lys Lys Arg Asp Tyr Gln Arg 
                885                 890                 895     


Leu Gly Trp Pro Ser Pro Asp Glu Cys Leu Lys Leu Arg Trp Val Glu 
            900                 905                 910         


Leu Thr Ala Ile Val Ser Thr Trp Leu Ala Val Ser Ser Lys Asn Ile 
        915                 920                 925             


Asp Ile Thr Glu His Ile Asp Phe Ala Thr Pro Ile Gln Gln Pro Ala 
    930                 935                 940                 


Met Glu Pro Leu Cys Asn Gly Asn Leu Pro Thr Ser Met His Thr Leu 
945                 950                 955                 960 


Asp His Leu His Gly Val Ser Asn Arg Ala Ser Leu His Tyr Thr Gly 
                965                 970                 975     


Glu Ser Gln Leu Thr Glu Val Leu Gln Asn Leu Gly Lys Asp Gln Tyr 
            980                 985                 990         


Pro Gln Gln Ser Leu Glu Gln Ile  Gly Thr Arg Ile Ala  Lys Val Leu 
        995                 1000                 1005             


Glu Lys  Asn Gln Thr Ser Trp  Val Leu Ser Ser Met  Ala Ala Leu 
    1010                 1015                 1020             


Tyr Trp  Arg Val Lys Gly Gln  Gly Lys Lys Ala Ile  Asp Cys Leu 
    1025                 1030                 1035             


Arg Gln  Ala Leu His Tyr Ala  Pro His Gln Met Lys  Asp Val Pro 
    1040                 1045                 1050             


Leu Ile  Ser Leu Ala Asn Ile  Leu His Asn Ala Lys  Leu Trp Asn 
    1055                 1060                 1065             


Asp Ala  Val Ile Val Ala Thr  Met Ala Val Glu Ile  Ala Pro His 
    1070                 1075                 1080             


Phe Ala  Val Asn His Phe Thr  Leu Gly Asn Val Tyr  Val Ala Met 
    1085                 1090                 1095             


Glu Glu  Phe Glu Lys Ala Leu  Val Trp Tyr Glu Ser  Thr Leu Lys 
    1100                 1105                 1110             


Leu Gln  Pro Glu Phe Val Pro  Ala Lys Asn Arg Ile  Gln Thr Ile 
    1115                 1120                 1125             


Gln Cys  His Leu Met Leu Lys  Lys Gly Arg Arg Ser  Pro 
    1130                 1135                 1140     


<210>  1563
<211>  843
<212>  PRT
<213>  homo sapiens

<400>  1563

Met Trp Thr Pro Glu Leu Ala Ile Leu Arg Gly Phe Pro Thr Glu Ala 
1               5                   10                  15      


Glu Arg Gln Gln Trp Lys Gln Glu Gly Val Val Gly Ser Glu Ser Gly 
            20                  25                  30          


Ser Phe Leu Gln Leu Leu Leu Glu Gly Asn Tyr Glu Ala Ile Phe Leu 
        35                  40                  45              


Asn Ser Met Thr Gln Asn Ile Phe Asn Ser Thr Thr Thr Ala Glu Glu 
    50                  55                  60                  


Lys Ile Asp Ser Tyr Leu Glu Lys Gln Val Val Thr Phe Leu Asp Tyr 
65                  70                  75                  80  


Ser Thr Asp Leu Asp Thr Thr Glu Arg Gln Gln Leu Ile Phe Leu Leu 
                85                  90                  95      


Gly Val Ser Ser Leu Gln Leu Phe Val Gln Ser Asn Trp Thr Gly Pro 
            100                 105                 110         


Pro Val Asp Leu His Pro Gln Asp Phe Leu Ser Ser Val Leu Phe Gln 
        115                 120                 125             


Gln Phe Ser Glu Val Lys Gly Leu Asp Ala Phe Val Leu Ser Leu Leu 
    130                 135                 140                 


Thr Leu Asp Gly Glu Ser Ile Tyr Ser Leu Thr Ser Lys Pro Ile Leu 
145                 150                 155                 160 


Leu Leu Leu Ala Arg Ile Ile Leu Val Asn Val Arg His Lys Leu Thr 
                165                 170                 175     


Ala Ile Gln Ser Leu Pro Trp Trp Thr Leu Arg Cys Val Asn Ile His 
            180                 185                 190         


Gln His Leu Leu Glu Glu Arg Ser Pro Leu Leu Phe Thr Leu Ala Glu 
        195                 200                 205             


Asn Cys Ile Asp Gln Val Met Lys Leu Gln Asn Leu Phe Val Asp Asp 
    210                 215                 220                 


Ser Gly Arg Tyr Leu Ala Ile Gln Phe His Leu Glu Cys Ala Tyr Val 
225                 230                 235                 240 


Phe Leu Tyr Tyr Tyr Glu Tyr Arg Lys Ala Lys Asp Gln Leu Asp Ile 
                245                 250                 255     


Ala Lys Asp Ile Ser Gln Leu Gln Ile Asp Leu Thr Gly Ala Leu Gly 
            260                 265                 270         


Lys Arg Thr Arg Phe Gln Glu Asn Tyr Val Ala Gln Leu Ile Leu Asp 
        275                 280                 285             


Val Arg Arg Glu Gly Asp Val Leu Ser Asn Cys Glu Phe Thr Pro Ala 
    290                 295                 300                 


Pro Thr Pro Gln Glu His Leu Thr Lys Asn Leu Glu Leu Asn Asp Asp 
305                 310                 315                 320 


Thr Ile Leu Asn Asp Ile Lys Leu Ala Asp Cys Glu Gln Phe Gln Met 
                325                 330                 335     


Pro Asp Leu Cys Ala Glu Glu Ile Ala Ile Ile Leu Gly Ile Cys Thr 
            340                 345                 350         


Asn Phe Gln Lys Asn Asn Pro Val His Thr Leu Thr Glu Val Glu Leu 
        355                 360                 365             


Leu Ala Phe Thr Ser Cys Leu Leu Ser Gln Pro Lys Phe Trp Ala Ile 
    370                 375                 380                 


Gln Thr Ser Ala Leu Ile Leu Arg Thr Lys Leu Glu Lys Gly Ser Thr 
385                 390                 395                 400 


Arg Arg Val Glu Arg Ala Met Arg Gln Thr Gln Ala Leu Ala Asp Gln 
                405                 410                 415     


Phe Glu Asp Lys Thr Thr Ser Val Leu Glu Arg Leu Lys Ile Phe Tyr 
            420                 425                 430         


Cys Cys Gln Val Pro Pro His Trp Ala Ile Gln Arg Gln Leu Ala Ser 
        435                 440                 445             


Leu Leu Phe Glu Leu Gly Cys Thr Ser Ser Ala Leu Gln Ile Phe Glu 
    450                 455                 460                 


Lys Leu Glu Met Trp Glu Asp Val Val Ile Cys Tyr Glu Arg Ala Gly 
465                 470                 475                 480 


Gln His Gly Lys Ala Glu Glu Ile Leu Arg Gln Glu Leu Glu Lys Lys 
                485                 490                 495     


Glu Thr Pro Ser Leu Tyr Cys Leu Leu Gly Asp Val Leu Gly Asp His 
            500                 505                 510         


Ser Cys Tyr Asp Lys Ala Trp Glu Leu Ser Arg Tyr Arg Ser Ala Arg 
        515                 520                 525             


Ala Gln Arg Ser Lys Ala Leu Leu His Leu Arg Asn Lys Glu Phe Gln 
    530                 535                 540                 


Glu Cys Val Glu Cys Phe Glu Arg Ser Val Lys Ile Asn Pro Met Gln 
545                 550                 555                 560 


Leu Gly Val Trp Phe Ser Leu Gly Cys Ala Tyr Leu Ala Leu Glu Asp 
                565                 570                 575     


Tyr Gln Gly Ser Ala Lys Ala Phe Gln Arg Cys Val Thr Leu Glu Pro 
            580                 585                 590         


Asp Asn Ala Glu Ala Trp Asn Asn Leu Ser Thr Ser Tyr Ile Arg Leu 
        595                 600                 605             


Lys Gln Lys Val Lys Ala Phe Arg Thr Leu Gln Glu Ala Leu Lys Cys 
    610                 615                 620                 


Asn Tyr Glu His Trp Gln Ile Trp Glu Asn Tyr Ile Leu Thr Ser Thr 
625                 630                 635                 640 


Asp Val Gly Glu Phe Ser Glu Ala Ile Lys Ala Tyr His Arg Leu Leu 
                645                 650                 655     


Asp Leu Arg Asp Lys Tyr Lys Asp Val Gln Val Leu Lys Ile Leu Val 
            660                 665                 670         


Arg Ala Val Ile Asp Gly Met Thr Asp Arg Ser Gly Asp Val Ala Thr 
        675                 680                 685             


Gly Leu Lys Gly Lys Leu Gln Glu Leu Phe Gly Arg Val Thr Ser Arg 
    690                 695                 700                 


Val Thr Asn Asp Gly Glu Ile Trp Arg Leu Tyr Ala His Val Tyr Gly 
705                 710                 715                 720 


Asn Gly Gln Ser Glu Lys Pro Asp Glu Asn Glu Lys Ala Phe Gln Cys 
                725                 730                 735     


Leu Ser Lys Ala Tyr Lys Cys Asp Thr Gln Ser Asn Cys Trp Glu Lys 
            740                 745                 750         


Asp Ile Thr Ser Phe Lys Glu Val Val Gln Arg Ala Leu Gly Leu Ala 
        755                 760                 765             


His Val Ala Ile Lys Cys Ser Lys Asn Lys Ser Ser Ser Gln Glu Ala 
    770                 775                 780                 


Val Gln Met Leu Ser Ser Val Arg Leu Asn Leu Arg Gly Leu Leu Ser 
785                 790                 795                 800 


Lys Ala Lys Gln Leu Phe Thr Asp Val Ala Thr Gly Glu Met Ser Arg 
                805                 810                 815     


Glu Leu Ala Asp Asp Ile Thr Ala Met Asp Thr Leu Val Thr Glu Leu 
            820                 825                 830         


Gln Asp Leu Ser Asn Gln Phe Arg Asn Gln Tyr 
        835                 840             


<210>  1564
<211>  779
<212>  PRT
<213>  homo sapiens

<400>  1564

Met Thr Pro Glu Phe Asp Glu Glu Val Val Phe Glu Asn Ser Pro Leu 
1               5                   10                  15      


Tyr Gln Tyr Leu Gln Asp Leu Gly His Thr Asp Phe Glu Ile Cys Ser 
            20                  25                  30          


Ser Leu Ser Pro Lys Thr Glu Lys Cys Thr Thr Glu Gly Gln Gln Lys 
        35                  40                  45              


Pro Pro Thr Arg Val Leu Pro Lys Gln Gly Ile Leu Leu Lys Val Ala 
    50                  55                  60                  


Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys Asp 
65                  70                  75                  80  


Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu His 
                85                  90                  95      


Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu Ile 
            100                 105                 110         


Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln Gln 
        115                 120                 125             


Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn Ile 
    130                 135                 140                 


Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met Leu 
145                 150                 155                 160 


Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile Leu 
                165                 170                 175     


Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala Lys 
            180                 185                 190         


Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met Ala 
        195                 200                 205             


Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg Leu 
    210                 215                 220                 


Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser Ala 
225                 230                 235                 240 


Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu Ile 
                245                 250                 255     


Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln Ala 
            260                 265                 270         


Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn Ser 
        275                 280                 285             


Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys Glu 
    290                 295                 300                 


Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala His 
305                 310                 315                 320 


Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe Gln 
                325                 330                 335     


Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Leu Ala Leu Leu 
            340                 345                 350         


Leu Ser Thr Ala Asn Ser Pro Pro Gly Pro Leu Leu Thr Pro Ala Leu 
        355                 360                 365             


Leu Pro His Arg Ile Leu Ser Asp Val Thr Gln Gly Leu Pro His Ala 
    370                 375                 380                 


His Ser Ala Cys Leu Glu Glu Leu Lys Arg Ser Tyr Glu Phe Tyr Arg 
385                 390                 395                 400 


Tyr Phe Glu Thr Gln His Gln Ser Val Pro Gln Cys Leu Ser Lys Thr 
                405                 410                 415     


Gln Gln Lys Ser Arg Glu Leu Asn Asn Val His Thr Ala Val Arg Ser 
            420                 425                 430         


Leu Gln Leu His Leu Lys Ala Leu Leu Asn Glu Val Ile Ile Leu Glu 
        435                 440                 445             


Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu Val 
    450                 455                 460                 


Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln Pro 
465                 470                 475                 480 


His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln Val 
                485                 490                 495     


Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu Ile 
            500                 505                 510         


Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro Thr 
        515                 520                 525             


Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu Glu 
    530                 535                 540                 


Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp Asp 
545                 550                 555                 560 


Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu His 
                565                 570                 575     


Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly Phe 
            580                 585                 590         


Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe Ser 
        595                 600                 605             


Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu Pro 
    610                 615                 620                 


Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val Ser 
625                 630                 635                 640 


Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp Asn 
                645                 650                 655     


Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly Lys 
            660                 665                 670         


Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu Glu 
        675                 680                 685             


Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp Gly 
    690                 695                 700                 


Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln Pro 
705                 710                 715                 720 


Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe Thr 
                725                 730                 735     


Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser Phe 
            740                 745                 750         


Thr Thr Met Gln Glu Gln Thr Phe Gly Gly Glu Glu Glu Glu Gln Ile 
        755                 760                 765             


Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys 
    770                 775                 


<210>  1565
<211>  500
<212>  PRT
<213>  homo sapiens

<400>  1565

Met Ile Ile Ser His Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu 
1               5                   10                  15      


Ala Leu Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu 
            20                  25                  30          


His Ala Val Ile Leu Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu 
        35                  40                  45              


Glu Ala Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala 
    50                  55                  60                  


Val Lys Leu Ala Ala Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu 
65                  70                  75                  80  


Asp Gly Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr 
                85                  90                  95      


Leu Glu Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp 
            100                 105                 110         


Pro Trp Arg Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu 
        115                 120                 125             


Ala Lys Asp Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys 
    130                 135                 140                 


Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln 
145                 150                 155                 160 


Tyr Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg 
                165                 170                 175     


Tyr His Lys Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro 
            180                 185                 190         


Lys Asp Ser Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly 
        195                 200                 205             


Ile Phe Thr Cys Phe Asp Ile Phe Ser His Asp Pro Ala Val Val Val 
    210                 215                 220                 


Val Asp Glu Ser Ile Asp Ser Ile Leu Tyr Pro Thr Ala Trp Tyr Asn 
225                 230                 235                 240 


Thr Leu Pro Leu Leu Ser Ala Val Pro Phe His Ser Ala Trp Ala Lys 
                245                 250                 255     


Ala Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr Ser Met 
            260                 265                 270         


His Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys Val Tyr 
        275                 280                 285             


His Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser Glu Leu 
    290                 295                 300                 


Lys Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val Asp Trp 
305                 310                 315                 320 


His Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln Ser Asp 
                325                 330                 335     


Phe Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys Leu Lys 
            340                 345                 350         


Arg Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys His 
        355                 360                 365             


Leu Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr Ala Leu 
    370                 375                 380                 


Gly Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Ile Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr Cys Gly 
                405                 410                 415     


Glu Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser Leu Ser 
            420                 425                 430         


Gly Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu Ser Gly 
        435                 440                 445             


Ser Gln Leu Ala Pro Glu Arg His Tyr Glu Ile Ser Arg Asp Gly Arg 
    450                 455                 460                 


Leu Arg Ser Arg Ser Gly Ala Pro Leu Pro Val Leu Val Met Ala Leu 
465                 470                 475                 480 


Tyr Gly Arg Val Phe Glu Lys Asp Pro Pro Arg Leu Gly Gln Gly Ser 
                485                 490                 495     


Gly Lys Phe Gln 
            500 


<210>  1566
<211>  3095
<212>  PRT
<213>  homo sapiens

<400>  1566

Met Val Phe Glu Ser Val Val Val Asp Val Leu Asn Arg Phe Leu Gly 
1               5                   10                  15      


Asp Tyr Val Val Asp Leu Asp Thr Ser Gln Leu Ser Leu Gly Ile Trp 
            20                  25                  30          


Lys Gly Ala Val Ala Leu Lys Asn Leu Gln Ile Lys Glu Asn Ala Leu 
        35                  40                  45              


Ser Gln Leu Asp Val Pro Phe Lys Val Lys Val Gly His Ile Gly Asn 
    50                  55                  60                  


Leu Lys Leu Ile Ile Pro Trp Lys Asn Leu Tyr Thr Gln Pro Val Glu 
65                  70                  75                  80  


Ala Val Leu Glu Glu Ile Tyr Leu Leu Ile Val Pro Ser Ser Arg Ile 
                85                  90                  95      


Lys Tyr Asp Pro Leu Lys Glu Glu Lys Gln Leu Met Glu Ala Lys Gln 
            100                 105                 110         


Gln Glu Leu Lys Arg Ile Glu Glu Ala Lys Gln Lys Val Val Asp Gln 
        115                 120                 125             


Glu Gln His Leu Pro Glu Lys Gln Asp Thr Phe Ala Glu Lys Leu Val 
    130                 135                 140                 


Thr Gln Ile Ile Lys Asn Leu Gln Val Lys Ile Ser Ser Ile His Ile 
145                 150                 155                 160 


Arg Tyr Glu Asp Asp Ile Thr Asn Arg Asp Lys Pro Leu Ser Phe Gly 
                165                 170                 175     


Ile Ser Leu Gln Asn Leu Ser Met Gln Thr Thr Asp Gln Tyr Trp Val 
            180                 185                 190         


Pro Cys Leu His Asp Glu Thr Glu Lys Leu Val Arg Lys Leu Ile Arg 
        195                 200                 205             


Leu Asp Asn Leu Phe Ala Tyr Trp Asn Val Lys Ser Gln Met Phe Tyr 
    210                 215                 220                 


Leu Ser Asp Tyr Asp Asn Ser Leu Asp Asp Leu Lys Asn Gly Ile Val 
225                 230                 235                 240 


Asn Glu Asn Ile Val Pro Glu Gly Tyr Asp Phe Val Phe Arg Pro Ile 
                245                 250                 255     


Ser Ala Asn Ala Lys Leu Val Met Asn Arg Arg Ser Asp Phe Asp Phe 
            260                 265                 270         


Ser Ala Pro Lys Ile Asn Leu Glu Ile Glu Leu His Asn Ile Ala Ile 
        275                 280                 285             


Glu Phe Asn Lys Pro Gln Tyr Phe Ser Ile Met Glu Leu Leu Glu Ser 
    290                 295                 300                 


Val Asp Met Met Ala Gln Asn Leu Pro Tyr Arg Lys Phe Lys Pro Asp 
305                 310                 315                 320 


Val Pro Leu His His His Ala Arg Glu Trp Trp Ala Tyr Ala Ile His 
                325                 330                 335     


Gly Val Leu Glu Val Asn Val Cys Pro Arg Leu Trp Met Trp Ser Trp 
            340                 345                 350         


Lys His Ile Arg Lys His Arg Gln Lys Val Lys Gln Tyr Lys Glu Leu 
        355                 360                 365             


Tyr Lys Lys Lys Leu Thr Ser Lys Lys Pro Pro Gly Glu Leu Leu Val 
    370                 375                 380                 


Ser Leu Glu Glu Leu Glu Lys Thr Leu Asp Val Phe Asn Ile Thr Ile 
385                 390                 395                 400 


Ala Arg Gln Thr Ala Glu Val Glu Val Lys Lys Ala Gly Tyr Lys Ile 
                405                 410                 415     


Tyr Lys Glu Gly Val Lys Asp Pro Glu Asp Asn Lys Gly Trp Phe Ser 
            420                 425                 430         


Trp Leu Trp Ser Trp Ser Glu Gln Asn Thr Asn Glu Gln Gln Pro Asp 
        435                 440                 445             


Val Gln Pro Glu Thr Leu Glu Glu Met Leu Thr Pro Glu Glu Lys Ala 
    450                 455                 460                 


Leu Leu Tyr Glu Ala Ile Gly Tyr Ser Glu Thr Ala Val Asp Pro Thr 
465                 470                 475                 480 


Leu Leu Lys Thr Phe Glu Ala Leu Lys Phe Phe Val His Leu Lys Ser 
                485                 490                 495     


Met Ser Ile Val Leu Arg Glu Asn His Gln Lys Pro Glu Leu Val Asp 
            500                 505                 510         


Ile Val Ile Glu Glu Phe Ser Thr Leu Ile Val Gln Arg Pro Gly Ala 
        515                 520                 525             


Gln Ala Ile Lys Phe Glu Thr Lys Ile Asp Ser Phe His Ile Thr Gly 
    530                 535                 540                 


Leu Pro Asp Asn Ser Glu Lys Pro Arg Leu Leu Ser Ser Leu Asp Asp 
545                 550                 555                 560 


Ala Met Ser Leu Phe Gln Ile Thr Phe Glu Ile Asn Pro Leu Asp Glu 
                565                 570                 575     


Thr Val Ser Gln Arg Cys Ile Ile Glu Ala Glu Pro Leu Glu Ile Ile 
            580                 585                 590         


Tyr Asp Ala Arg Thr Val Asn Ser Ile Val Glu Phe Phe Arg Pro Pro 
        595                 600                 605             


Lys Glu Val His Leu Ala Gln Leu Thr Ala Ala Thr Leu Thr Lys Leu 
    610                 615                 620                 


Glu Glu Phe Arg Ser Lys Thr Ala Thr Gly Leu Leu Tyr Ile Ile Glu 
625                 630                 635                 640 


Thr Gln Lys Val Leu Asp Leu Lys Ile Asn Leu Lys Ala Ser Tyr Ile 
                645                 650                 655     


Ile Val Pro Gln Asp Gly Ile Phe Ser Pro Thr Ser Asn Leu Leu Leu 
            660                 665                 670         


Leu Asp Leu Gly His Leu Lys Val Thr Ser Lys Ser Arg Ser Glu Leu 
        675                 680                 685             


Pro Asp Val Lys Gln Gly Glu Ala Asn Leu Lys Glu Ile Met Asp Arg 
    690                 695                 700                 


Ala Tyr Asp Ser Phe Asp Ile Gln Leu Thr Ser Val Gln Leu Leu Tyr 
705                 710                 715                 720 


Ser Arg Val Gly Asp Asn Trp Arg Glu Ala Arg Lys Leu Ser Val Ser 
                725                 730                 735     


Thr Gln His Ile Leu Val Pro Met His Phe Asn Leu Glu Leu Ser Lys 
            740                 745                 750         


Ala Met Val Phe Met Asp Val Arg Met Pro Lys Phe Lys Ile Tyr Gly 
        755                 760                 765             


Lys Leu Pro Leu Ile Ser Leu Arg Ile Ser Asp Lys Lys Leu Gln Gly 
    770                 775                 780                 


Ile Met Glu Leu Ile Glu Ser Ile Pro Lys Pro Glu Pro Val Thr Glu 
785                 790                 795                 800 


Val Ser Ala Pro Val Lys Ser Phe Gln Ile Gln Thr Ser Thr Ser Leu 
                805                 810                 815     


Gly Thr Ser Gln Ile Ser Gln Lys Ile Ile Pro Leu Leu Glu Leu Pro 
            820                 825                 830         


Ser Val Ser Glu Asp Asp Ser Glu Glu Glu Phe Phe Asp Ala Pro Cys 
        835                 840                 845             


Ser Pro Leu Glu Glu Pro Leu Gln Phe Pro Thr Gly Val Lys Ser Ile 
    850                 855                 860                 


Arg Thr Arg Lys Leu Gln Lys Gln Asp Cys Ser Val Asn Met Thr Thr 
865                 870                 875                 880 


Phe Lys Ile Arg Phe Glu Val Pro Lys Val Leu Ile Glu Phe Tyr His 
                885                 890                 895     


Leu Val Gly Asp Cys Glu Leu Ser Val Val Glu Ile Leu Val Leu Gly 
            900                 905                 910         


Leu Gly Ala Glu Ile Glu Ile Arg Thr Tyr Asp Leu Lys Ala Asn Ala 
        915                 920                 925             


Phe Leu Lys Glu Phe Cys Leu Lys Cys Pro Glu Tyr Leu Asp Glu Asn 
    930                 935                 940                 


Lys Lys Pro Val Tyr Leu Val Thr Thr Leu Asp Asn Thr Met Glu Asp 
945                 950                 955                 960 


Leu Leu Thr Leu Glu Tyr Val Lys Ala Glu Lys Asn Val Pro Asp Leu 
                965                 970                 975     


Lys Ser Thr Tyr Asn Asn Val Leu Gln Leu Ile Lys Val Asn Phe Ser 
            980                 985                 990         


Ser Leu Asp Ile His Leu His Thr  Glu Ala Leu Leu Asn  Thr Ile Asn 
        995                 1000                 1005             


Tyr Leu  His Asn Ile Leu Pro  Gln Ser Glu Glu Lys  Ser Ala Pro 
    1010                 1015                 1020             


Val Ser  Thr Thr Glu Thr Glu  Asp Lys Gly Asp Val  Ile Lys Lys 
    1025                 1030                 1035             


Leu Ala  Leu Lys Leu Ser Thr  Asn Glu Asp Ile Ile  Thr Leu Gln 
    1040                 1045                 1050             


Ile Leu  Ala Glu Leu Ser Cys  Leu Gln Ile Phe Ile  Gln Asp Gln 
    1055                 1060                 1065             


Lys Cys  Asn Ile Ser Glu Ile  Lys Ile Glu Gly Leu  Asp Ser Glu 
    1070                 1075                 1080             


Met Ile  Met Arg Pro Ser Glu  Thr Glu Ile Asn Ala  Lys Leu Arg 
    1085                 1090                 1095             


Asn Ile  Ile Val Leu Asp Ser  Asp Ile Thr Ala Ile  Tyr Lys Lys 
    1100                 1105                 1110             


Ala Val  Tyr Ile Thr Gly Lys  Glu Val Phe Ser Phe  Lys Met Val 
    1115                 1120                 1125             


Ser Tyr  Met Asp Ala Thr Ala  Gly Ser Ala Tyr Thr  Asp Met Asn 
    1130                 1135                 1140             


Val Val  Asp Ile Gln Val Asn  Leu Ile Val Gly Cys  Ile Glu Val 
    1145                 1150                 1155             


Val Phe  Val Thr Lys Phe Leu  Tyr Ser Ile Leu Ala  Phe Ile Asp 
    1160                 1165                 1170             


Asn Phe  Gln Ala Ala Lys Gln  Ala Leu Ala Glu Ala  Thr Val Gln 
    1175                 1180                 1185             


Ala Ala  Gly Met Ala Ala Thr  Gly Val Lys Glu Leu  Ala Gln Arg 
    1190                 1195                 1200             


Ser Ser  Arg Met Ala Leu Asp  Ile Asn Ile Lys Ala  Pro Val Val 
    1205                 1210                 1215             


Val Ile  Pro Gln Ser Pro Val  Ser Glu Asn Val Phe  Val Ala Asp 
    1220                 1225                 1230             


Phe Gly  Leu Ile Thr Met Thr  Asn Thr Phe His Met  Ile Thr Glu 
    1235                 1240                 1245             


Ser Gln  Ser Ser Pro Pro Pro  Val Ile Asp Leu Ile  Thr Ile Lys 
    1250                 1255                 1260             


Leu Ser  Glu Met Arg Leu Tyr  Arg Ser Arg Phe Ile  Asn Asp Ala 
    1265                 1270                 1275             


Tyr Gln  Glu Val Leu Asp Leu  Leu Leu Pro Leu Asn  Leu Glu Val 
    1280                 1285                 1290             


Val Val  Glu Arg Asn Leu Cys  Trp Glu Trp Tyr Gln  Glu Val Pro 
    1295                 1300                 1305             


Cys Phe  Asn Val Asn Ala Gln  Leu Lys Pro Met Glu  Phe Ile Leu 
    1310                 1315                 1320             


Ser Gln  Glu Asp Ile Thr Thr  Ile Phe Lys Thr Leu  His Gly Asn 
    1325                 1330                 1335             


Ile Trp  Tyr Glu Lys Asp Gly  Ser Ala Ser Pro Ala  Val Thr Lys 
    1340                 1345                 1350             


Asp Gln  Tyr Ser Ala Thr Ser  Gly Val Thr Thr Asn  Ala Ser His 
    1355                 1360                 1365             


His Ser  Gly Gly Ala Thr Val  Val Thr Ala Ala Val  Val Glu Val 
    1370                 1375                 1380             


His Ser  Arg Ala Leu Leu Val  Lys Thr Thr Leu Asn  Ile Ser Phe 
    1385                 1390                 1395             


Lys Thr  Asp Asp Leu Thr Met  Val Leu Tyr Ser Pro  Gly Pro Lys 
    1400                 1405                 1410             


Gln Ala  Ser Phe Thr Asp Val  Arg Asp Pro Ser Leu  Lys Leu Ala 
    1415                 1420                 1425             


Glu Phe  Lys Leu Glu Asn Ile  Ile Ser Thr Leu Lys  Met Tyr Thr 
    1430                 1435                 1440             


Asp Gly  Ser Thr Phe Ser Ser  Phe Ser Leu Lys Asn  Cys Ile Leu 
    1445                 1450                 1455             


Asp Asp  Lys Arg Pro His Val  Lys Lys Ala Thr Pro  Arg Met Ile 
    1460                 1465                 1470             


Gly Leu  Thr Val Gly Phe Asp  Lys Lys Asp Met Met  Asp Ile Lys 
    1475                 1480                 1485             


Tyr Arg  Lys Val Arg Asp Gly  Cys Val Thr Asp Ala  Val Phe Gln 
    1490                 1495                 1500             


Glu Met  Tyr Ile Cys Ala Ser  Val Glu Phe Leu Gln  Thr Val Ala 
    1505                 1510                 1515             


Asn Val  Phe Leu Glu Ala Tyr  Thr Thr Gly Thr Ala  Val Glu Thr 
    1520                 1525                 1530             


Ser Val  Gln Thr Trp Thr Ala  Lys Glu Glu Val Pro  Thr Gln Glu 
    1535                 1540                 1545             


Ser Val  Lys Trp Glu Ile Asn  Val Ile Ile Lys Asn  Pro Glu Ile 
    1550                 1555                 1560             


Val Phe  Val Ala Asp Met Thr  Lys Asn Asp Ala Pro  Ala Leu Val 
    1565                 1570                 1575             


Ile Thr  Thr Gln Cys Glu Ile  Cys Tyr Lys Gly Asn  Leu Glu Asn 
    1580                 1585                 1590             


Ser Thr  Met Thr Ala Ala Ile  Lys Asp Leu Gln Val  Arg Ala Cys 
    1595                 1600                 1605             


Pro Phe  Leu Pro Val Lys Arg  Lys Gly Lys Ile Thr  Thr Val Leu 
    1610                 1615                 1620             


Gln Pro  Cys Asp Leu Phe Tyr  Gln Thr Thr Gln Lys  Gly Thr Asp 
    1625                 1630                 1635             


Pro Gln  Val Ile Asp Met Ser  Val Lys Ser Leu Thr  Leu Lys Val 
    1640                 1645                 1650             


Ser Pro  Val Ile Ile Asn Thr  Met Ile Thr Ile Thr  Ser Ala Leu 
    1655                 1660                 1665             


Tyr Thr  Thr Lys Glu Thr Ile  Pro Glu Glu Thr Ala  Ser Ser Thr 
    1670                 1675                 1680             


Ala His  Leu Trp Glu Lys Lys  Asp Thr Lys Thr Leu  Lys Met Trp 
    1685                 1690                 1695             


Phe Leu  Glu Glu Ser Asn Glu  Thr Glu Lys Ile Ala  Pro Thr Thr 
    1700                 1705                 1710             


Glu Leu  Val Pro Lys Gly Glu  Met Ile Lys Met Asn  Ile Asp Ser 
    1715                 1720                 1725             


Ile Phe  Ile Val Leu Glu Ala  Gly Ile Gly His Arg  Thr Val Pro 
    1730                 1735                 1740             


Met Leu  Leu Ala Lys Ser Arg  Phe Ser Gly Glu Gly  Lys Asn Trp 
    1745                 1750                 1755             


Ser Ser  Leu Ile Asn Leu His  Cys Gln Leu Glu Leu  Glu Val His 
    1760                 1765                 1770             


Tyr Tyr  Asn Glu Met Phe Gly  Val Trp Glu Pro Leu  Leu Glu Pro 
    1775                 1780                 1785             


Leu Glu  Ile Asp Gln Thr Glu  Asp Phe Arg Pro Trp  Asn Leu Gly 
    1790                 1795                 1800             


Ile Lys  Met Lys Lys Lys Ala  Lys Met Ala Ile Val  Glu Ser Asp 
    1805                 1810                 1815             


Pro Glu  Glu Glu Asn Tyr Lys  Val Pro Glu Tyr Lys  Thr Val Ile 
    1820                 1825                 1830             


Ser Phe  His Ser Lys Asp Gln  Leu Asn Ile Thr Leu  Ser Lys Cys 
    1835                 1840                 1845             


Gly Leu  Val Met Leu Asn Asn  Leu Val Lys Ala Phe  Thr Glu Ala 
    1850                 1855                 1860             


Ala Thr  Gly Ser Ser Ala Asp  Phe Val Lys Asp Leu  Ala Pro Phe 
    1865                 1870                 1875             


Met Ile  Leu Asn Ser Leu Gly  Leu Thr Ile Ser Val  Ser Pro Ser 
    1880                 1885                 1890             


Asp Ser  Phe Ser Val Leu Asn  Ile Pro Met Ala Lys  Ser Tyr Val 
    1895                 1900                 1905             


Leu Lys  Asn Gly Glu Ser Leu  Ser Met Asp Tyr Ile  Arg Thr Lys 
    1910                 1915                 1920             


Asp Asn  Asp His Phe Asn Ala  Met Thr Ser Leu Ser  Ser Lys Leu 
    1925                 1930                 1935             


Phe Phe  Ile Leu Leu Thr Pro  Val Asn His Ser Thr  Ala Asp Lys 
    1940                 1945                 1950             


Ile Pro  Leu Thr Lys Val Gly  Arg Arg Leu Tyr Thr  Val Arg His 
    1955                 1960                 1965             


Arg Glu  Ser Gly Val Glu Arg  Ser Ile Val Cys Gln  Ile Asp Thr 
    1970                 1975                 1980             


Val Glu  Gly Ser Lys Lys Val  Thr Ile Arg Ser Pro  Val Gln Ile 
    1985                 1990                 1995             


Arg Asn  His Phe Ser Val Pro  Leu Ser Val Tyr Glu  Gly Asp Thr 
    2000                 2005                 2010             


Leu Leu  Gly Thr Ala Ser Pro  Glu Asn Glu Phe Asn  Ile Pro Leu 
    2015                 2020                 2025             


Gly Ser  Tyr Arg Ser Phe Ile  Phe Leu Lys Pro Glu  Asp Glu Asn 
    2030                 2035                 2040             


Tyr Gln  Met Cys Glu Gly Ile  Asp Phe Glu Glu Ile  Ile Lys Asn 
    2045                 2050                 2055             


Asp Gly  Ala Leu Leu Lys Lys  Lys Cys Arg Ser Lys  Asn Pro Ser 
    2060                 2065                 2070             


Lys Glu  Ser Phe Leu Ile Asn  Ile Val Pro Glu Lys  Asp Asn Leu 
    2075                 2080                 2085             


Thr Ser  Leu Ser Val Tyr Ser  Glu Asp Gly Trp Asp  Leu Pro Tyr 
    2090                 2095                 2100             


Ile Met  His Leu Trp Pro Pro  Ile Leu Leu Arg Asn  Leu Leu Pro 
    2105                 2110                 2115             


Tyr Lys  Ile Ala Tyr Tyr Ile  Glu Gly Ile Glu Asn  Ser Val Phe 
    2120                 2125                 2130             


Thr Leu  Ser Glu Gly His Ser  Ala Gln Ile Cys Thr  Ala Gln Leu 
    2135                 2140                 2145             


Gly Lys  Ala Arg Leu His Leu  Lys Leu Leu Asp Tyr  Leu Asn His 
    2150                 2155                 2160             


Asp Trp  Lys Ser Glu Tyr His  Ile Lys Pro Asn Gln  Gln Asp Ile 
    2165                 2170                 2175             


Ser Phe  Val Ser Phe Thr Cys  Val Thr Glu Met Glu  Lys Thr Asp 
    2180                 2185                 2190             


Leu Asp  Ile Ala Val His Met  Thr Tyr Asn Thr Gly  Gln Thr Val 
    2195                 2200                 2205             


Val Ala  Phe His Ser Pro Tyr  Trp Met Val Asn Lys  Thr Gly Arg 
    2210                 2215                 2220             


Met Leu  Gln Tyr Lys Ala Asp  Gly Ile His Arg Lys  His Pro Pro 
    2225                 2230                 2235             


Asn Tyr  Lys Lys Pro Val Leu  Phe Ser Phe Gln Pro  Asn His Phe 
    2240                 2245                 2250             


Phe Asn  Asn Asn Lys Val Gln  Leu Met Val Thr Asp  Ser Glu Leu 
    2255                 2260                 2265             


Ser Asn  Gln Phe Ser Ile Asp  Thr Val Gly Ser His  Gly Ala Val 
    2270                 2275                 2280             


Lys Cys  Lys Gly Leu Lys Met  Asp Tyr Gln Val Gly  Val Thr Ile 
    2285                 2290                 2295             


Asp Leu  Ser Ser Phe Asn Ile  Thr Arg Ile Val Thr  Phe Thr Pro 
    2300                 2305                 2310             


Phe Tyr  Met Ile Lys Asn Lys  Ser Lys Tyr His Ile  Ser Val Ala 
    2315                 2320                 2325             


Glu Glu  Gly Asn Asp Lys Trp  Leu Ser Leu Asp Leu  Glu Gln Cys 
    2330                 2335                 2340             


Ile Pro  Phe Trp Pro Glu Tyr  Ala Ser Ser Lys Leu  Leu Ile Gln 
    2345                 2350                 2355             


Val Glu  Arg Ser Glu Asp Pro  Pro Lys Arg Ile Tyr  Phe Asn Lys 
    2360                 2365                 2370             


Gln Glu  Asn Cys Ile Leu Leu  Arg Leu Asp Asn Glu  Leu Gly Gly 
    2375                 2380                 2385             


Ile Ile  Ala Glu Val Asn Leu  Ala Glu His Ser Thr  Val Ile Thr 
    2390                 2395                 2400             


Phe Leu  Asp Tyr His Asp Gly  Ala Ala Thr Phe Leu  Leu Ile Asn 
    2405                 2410                 2415             


His Thr  Lys Asn Glu Leu Val  Gln Tyr Asn Gln Ser  Ser Leu Ser 
    2420                 2425                 2430             


Glu Ile  Glu Asp Ser Leu Pro  Pro Gly Lys Ala Val  Phe Tyr Thr 
    2435                 2440                 2445             


Trp Ala  Asp Pro Val Gly Ser  Arg Arg Leu Lys Trp  Arg Cys Arg 
    2450                 2455                 2460             


Lys Ser  His Gly Glu Val Thr  Gln Lys Asp Asp Met  Met Met Pro 
    2465                 2470                 2475             


Ile Asp  Leu Gly Glu Lys Thr  Ile Tyr Leu Val Ser  Phe Phe Glu 
    2480                 2485                 2490             


Gly Leu  Gln Arg Ile Ile Leu  Phe Thr Glu Asp Pro  Arg Val Phe 
    2495                 2500                 2505             


Lys Val  Thr Tyr Glu Ser Glu  Lys Ala Glu Leu Ala  Glu Gln Glu 
    2510                 2515                 2520             


Ile Ala  Val Ala Leu Gln Asp  Val Gly Ile Ser Leu  Val Asn Asn 
    2525                 2530                 2535             


Tyr Thr  Lys Gln Glu Val Ala  Tyr Ile Gly Ile Thr  Ser Ser Asp 
    2540                 2545                 2550             


Val Val  Trp Glu Thr Lys Pro  Lys Lys Lys Ala Arg  Trp Lys Pro 
    2555                 2560                 2565             


Met Ser  Val Lys His Thr Glu  Lys Leu Glu Arg Glu  Phe Lys Glu 
    2570                 2575                 2580             


Tyr Thr  Glu Ser Ser Pro Ser  Glu Asp Lys Val Ile  Gln Leu Asp 
    2585                 2590                 2595             


Thr Asn  Val Pro Val Arg Leu  Thr Pro Thr Gly His  Asn Met Lys 
    2600                 2605                 2610             


Ile Leu  Gln Pro His Val Ile  Ala Leu Arg Arg Asn  Tyr Leu Pro 
    2615                 2620                 2625             


Ala Leu  Lys Val Glu Tyr Asn  Thr Ser Ala His Gln  Ser Ser Phe 
    2630                 2635                 2640             


Arg Ile  Gln Ile Tyr Arg Ile  Gln Ile Gln Asn Gln  Ile His Gly 
    2645                 2650                 2655             


Ala Val  Phe Pro Phe Val Phe  Tyr Pro Val Lys Pro  Pro Lys Ser 
    2660                 2665                 2670             


Val Thr  Met Asp Ser Ala Pro  Lys Pro Phe Thr Asp  Val Ser Ile 
    2675                 2680                 2685             


Val Met  Arg Ser Ala Gly His  Ser Gln Ile Ser Arg  Ile Lys Tyr 
    2690                 2695                 2700             


Phe Lys  Val Leu Ile Gln Glu  Met Asp Leu Arg Leu  Asp Leu Gly 
    2705                 2710                 2715             


Phe Ile  Tyr Ala Leu Thr Asp  Leu Met Thr Glu Ala  Glu Val Thr 
    2720                 2725                 2730             


Glu Asn  Thr Glu Val Glu Leu  Phe His Lys Asp Ile  Glu Ala Phe 
    2735                 2740                 2745             


Lys Glu  Glu Tyr Lys Thr Ala  Ser Leu Val Asp Gln  Ser Gln Val 
    2750                 2755                 2760             


Ser Leu  Tyr Glu Tyr Phe His  Ile Ser Pro Ile Lys  Leu His Leu 
    2765                 2770                 2775             


Ser Val  Ser Leu Ser Ser Gly  Arg Glu Glu Ala Lys  Asp Ser Lys 
    2780                 2785                 2790             


Gln Asn  Gly Gly Leu Ile Pro  Val His Ser Leu Asn  Leu Leu Leu 
    2795                 2800                 2805             


Lys Ser  Ile Gly Ala Thr Leu  Thr Asp Val Gln Asp  Val Val Phe 
    2810                 2815                 2820             


Lys Leu  Ala Phe Phe Glu Leu  Asn Tyr Gln Phe His  Thr Thr Ser 
    2825                 2830                 2835             


Asp Leu  Gln Ser Glu Val Ile  Arg His Tyr Ser Lys  Gln Ala Ile 
    2840                 2845                 2850             


Lys Gln  Met Tyr Val Leu Ile  Leu Gly Leu Asp Val  Leu Gly Asn 
    2855                 2860                 2865             


Pro Phe  Gly Leu Ile Arg Glu  Phe Ser Glu Gly Val  Glu Ala Phe 
    2870                 2875                 2880             


Phe Tyr  Glu Pro Tyr Gln Gly  Ala Ile Gln Gly Pro  Glu Glu Phe 
    2885                 2890                 2895             


Val Glu  Gly Met Ala Leu Gly  Leu Lys Ala Leu Val  Gly Gly Ala 
    2900                 2905                 2910             


Val Gly  Gly Leu Ala Gly Ala  Ala Ser Lys Ile Thr  Gly Ala Met 
    2915                 2920                 2925             


Ala Lys  Gly Val Ala Ala Met  Thr Met Asp Glu Asp  Tyr Gln Gln 
    2930                 2935                 2940             


Lys Arg  Arg Glu Ala Met Asn  Lys Gln Pro Ala Gly  Phe Arg Glu 
    2945                 2950                 2955             


Gly Ile  Thr Arg Gly Gly Lys  Gly Leu Val Ser Gly  Phe Val Ser 
    2960                 2965                 2970             


Gly Ile  Thr Gly Ile Val Thr  Lys Pro Ile Lys Gly  Ala Gln Lys 
    2975                 2980                 2985             


Gly Gly  Ala Ala Gly Phe Phe  Lys Gly Val Gly Lys  Gly Leu Val 
    2990                 2995                 3000             


Gly Ala  Val Ala Arg Pro Thr  Gly Gly Ile Ile Asp  Met Ala Ser 
    3005                 3010                 3015             


Ser Thr  Phe Gln Gly Ile Lys  Arg Ala Thr Glu Thr  Ser Glu Val 
    3020                 3025                 3030             


Glu Ser  Leu Arg Pro Pro Arg  Phe Phe Asn Glu Asp  Gly Val Ile 
    3035                 3040                 3045             


Arg Pro  Tyr Arg Leu Arg Asp  Gly Thr Gly Asn Gln  Met Leu Gln 
    3050                 3055                 3060             


Lys Ile  Gln Phe Tyr Arg Glu  Trp Ile Met Thr His  Ser Ser Ser 
    3065                 3070                 3075             


Ser Asp  Asp Asp Asp Asp Asp  Asp Asp Asp Asp Glu  Ser Asp Leu 
    3080                 3085                 3090             


Asn His  
    3095 


<210>  1567
<211>  863
<212>  PRT
<213>  homo sapiens

<400>  1567

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln 
                405                 410                 415     


Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr 
            420                 425                 430         


Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly 
        435                 440                 445             


Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys 
    450                 455                 460                 


Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe 
465                 470                 475                 480 


Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn 
                485                 490                 495     


Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu 
            500                 505                 510         


Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala 
        515                 520                 525             


Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Met 
    530                 535                 540                 


Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser 
545                 550                 555                 560 


Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser 
                565                 570                 575     


Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His 
            580                 585                 590         


Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro 
        595                 600                 605             


Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asp Glu Asn Glu Thr Ile Leu 
    610                 615                 620                 


Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His 
625                 630                 635                 640 


Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu 
                645                 650                 655     


Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn 
            660                 665                 670         


Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu 
        675                 680                 685             


Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val 
    690                 695                 700                 


Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln 
705                 710                 715                 720 


Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys 
                725                 730                 735     


Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser 
            740                 745                 750         


Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr 
        755                 760                 765             


Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile 
    770                 775                 780                 


Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala 
785                 790                 795                 800 


Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser 
                805                 810                 815     


His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn 
            820                 825                 830         


Glu Ile Phe Leu Ser Ile Glu Ile Gly Ser Cys Tyr Val Ala Gln Val 
        835                 840                 845             


Asp Leu Glu Leu Leu Ala Ser Asn Asp Pro Pro Thr Ser Thr Ser 
    850                 855                 860             


<210>  1568
<211>  3710
<212>  PRT
<213>  homo sapiens

<400>  1568

Met Val Leu Glu Ser Val Val Ala Asp Leu Leu Asn Arg Phe Leu Gly 
1               5                   10                  15      


Asp Tyr Val Glu Asn Leu Asn Lys Ser Gln Leu Lys Leu Gly Ile Trp 
            20                  25                  30          


Gly Gly Asn Val Ala Leu Asp Asn Leu Gln Ile Lys Glu Asn Ala Leu 
        35                  40                  45              


Ser Glu Leu Asp Val Pro Phe Lys Val Lys Ala Gly Gln Ile Asp Lys 
    50                  55                  60                  


Leu Thr Leu Lys Ile Pro Trp Lys Asn Leu Tyr Gly Glu Ala Val Val 
65                  70                  75                  80  


Ala Thr Leu Glu Gly Leu Tyr Leu Leu Val Val Pro Gly Ala Ser Ile 
                85                  90                  95      


Lys Tyr Asp Ala Val Lys Glu Glu Lys Ser Leu Gln Asp Val Lys Gln 
            100                 105                 110         


Lys Glu Leu Ser Arg Ile Glu Glu Ala Leu Gln Lys Ala Ala Glu Lys 
        115                 120                 125             


Asp Lys Pro Lys Glu Ala Lys Lys Asp Thr Phe Val Glu Lys Leu Ala 
    130                 135                 140                 


Thr Gln Val Ile Lys Asn Val Gln Val Lys Ile Thr Asp Ile His Ile 
145                 150                 155                 160 


Lys Tyr Glu Asp Asp Val Thr Asp Pro Lys Arg Pro Leu Ser Phe Gly 
                165                 170                 175     


Val Thr Leu Gly Glu Leu Ser Leu Leu Thr Ala Asn Glu His Trp Thr 
            180                 185                 190         


Pro Cys Ile Leu Asn Glu Ala Asp Lys Ile Ile Tyr Lys Leu Ile Arg 
        195                 200                 205             


Leu Asp Ser Leu Ser Ala Tyr Trp Asn Val Asn Cys Ser Met Ser Tyr 
    210                 215                 220                 


Gln Arg Ser Arg Glu Gln Ile Leu Asp Gln Leu Lys Asn Glu Ile Leu 
225                 230                 235                 240 


Thr Ser Gly Asn Ile Pro Pro Asn Tyr Gln Tyr Ile Phe Gln Pro Ile 
                245                 250                 255     


Ser Ala Ser Ala Lys Leu Tyr Met Asn Pro Tyr Ala Glu Ser Glu Leu 
            260                 265                 270         


Lys Thr Pro Lys Leu Asp Cys Asn Ile Glu Ile Gln Asn Ile Ala Ile 
        275                 280                 285             


Glu Leu Thr Lys Pro Gln Tyr Leu Ser Met Ile Asp Leu Leu Glu Ser 
    290                 295                 300                 


Val Asp Tyr Met Val Arg Asn Ala Pro Tyr Arg Lys Tyr Lys Pro Tyr 
305                 310                 315                 320 


Leu Pro Leu His Thr Asn Gly Arg Arg Trp Trp Lys Tyr Ala Ile Asp 
                325                 330                 335     


Ser Val Leu Glu Val His Ile Arg Arg Tyr Thr Gln Met Trp Ser Trp 
            340                 345                 350         


Ser Asn Ile Lys Lys His Arg Gln Leu Leu Lys Ser Tyr Lys Ile Ala 
        355                 360                 365             


Tyr Lys Asn Lys Leu Thr Gln Ser Lys Val Ser Glu Glu Ile Gln Lys 
    370                 375                 380                 


Glu Ile Gln Asp Leu Glu Lys Thr Leu Asp Val Phe Asn Ile Ile Leu 
385                 390                 395                 400 


Ala Arg Gln Gln Ala Gln Val Glu Val Ile Arg Ser Gly Gln Lys Leu 
                405                 410                 415     


Arg Lys Lys Ser Ala Asp Thr Gly Glu Lys Arg Gly Gly Trp Phe Ser 
            420                 425                 430         


Gly Leu Trp Gly Lys Lys Glu Ser Lys Lys Lys Asp Glu Glu Ser Leu 
        435                 440                 445             


Ile Pro Glu Thr Ile Asp Asp Leu Met Thr Pro Glu Glu Lys Asp Lys 
    450                 455                 460                 


Leu Phe Thr Ala Ile Gly Tyr Ser Glu Ser Thr His Asn Leu Thr Leu 
465                 470                 475                 480 


Pro Lys Gln Tyr Val Ala His Ile Met Thr Leu Lys Leu Val Ser Thr 
                485                 490                 495     


Ser Val Thr Ile Arg Glu Asn Lys Asn Ile Pro Glu Ile Leu Lys Ile 
            500                 505                 510         


Gln Ile Ile Gly Leu Gly Thr Gln Val Ser Gln Arg Pro Gly Ala Gln 
        515                 520                 525             


Ala Leu Lys Val Glu Ala Lys Leu Glu His Trp Tyr Ile Thr Gly Leu 
    530                 535                 540                 


Arg Gln Gln Asp Ile Val Pro Ser Leu Val Ala Ser Ile Gly Asp Thr 
545                 550                 555                 560 


Thr Ser Ser Leu Leu Lys Ile Lys Phe Glu Thr Asn Pro Glu Asp Ser 
                565                 570                 575     


Pro Ala Asp Gln Thr Leu Ile Val Gln Ser Gln Pro Val Glu Val Ile 
            580                 585                 590         


Tyr Asp Ala Lys Thr Val Asn Ala Val Val Glu Phe Phe Gln Ser Asn 
        595                 600                 605             


Lys Gly Leu Asp Leu Glu Gln Ile Thr Ser Ala Thr Leu Met Lys Leu 
    610                 615                 620                 


Glu Glu Ile Lys Glu Arg Thr Ala Thr Gly Leu Thr His Ile Ile Glu 
625                 630                 635                 640 


Thr Arg Lys Val Leu Asp Leu Arg Ile Asn Leu Lys Pro Ser Tyr Leu 
                645                 650                 655     


Val Val Pro Gln Thr Gly Phe His His Glu Lys Ser Asp Leu Leu Ile 
            660                 665                 670         


Leu Asp Phe Gly Thr Phe Gln Leu Asn Ser Lys Asp Gln Gly Leu Gln 
        675                 680                 685             


Lys Thr Thr Asn Ser Ser Leu Glu Glu Ile Met Asp Lys Ala Tyr Asp 
    690                 695                 700                 


Lys Phe Asp Val Glu Ile Lys Asn Val Gln Leu Leu Phe Ala Arg Ala 
705                 710                 715                 720 


Glu Glu Thr Trp Lys Lys Cys Arg Phe Gln His Pro Ser Thr Met His 
                725                 730                 735     


Ile Leu Gln Pro Met Asp Ile His Val Glu Leu Ala Lys Ala Met Val 
            740                 745                 750         


Glu Lys Asp Ile Arg Met Ala Arg Phe Lys Val Ser Gly Gly Leu Pro 
        755                 760                 765             


Leu Met His Val Arg Ile Ser Asp Gln Lys Met Lys Asp Val Leu Tyr 
    770                 775                 780                 


Leu Met Asn Ser Ile Pro Leu Pro Gln Lys Ser Ser Ala Gln Ser Pro 
785                 790                 795                 800 


Glu Arg Gln Val Ser Ser Ile Pro Ile Ile Ser Gly Gly Thr Lys Gly 
                805                 810                 815     


Leu Leu Gly Thr Ser Leu Leu Leu Asp Thr Val Glu Ser Glu Ser Asp 
            820                 825                 830         


Asp Glu Tyr Phe Asp Ala Glu Asp Gly Glu Pro Gln Thr Cys Lys Ser 
        835                 840                 845             


Met Lys Gly Ser Glu Leu Lys Lys Ala Ala Glu Val Pro Asn Glu Glu 
    850                 855                 860                 


Leu Ile Asn Leu Leu Leu Lys Phe Glu Ile Lys Glu Val Ile Leu Glu 
865                 870                 875                 880 


Phe Thr Lys Gln Gln Lys Glu Glu Asp Thr Ile Leu Val Phe Asn Val 
                885                 890                 895     


Thr Gln Leu Gly Thr Glu Ala Thr Met Arg Thr Phe Asp Leu Thr Val 
            900                 905                 910         


Val Ser Tyr Leu Lys Lys Ile Ser Leu Asp Tyr His Glu Ile Glu Gly 
        915                 920                 925             


Ser Lys Arg Lys Pro Leu His Leu Ile Ser Ser Ser Asp Lys Pro Gly 
    930                 935                 940                 


Leu Asp Leu Leu Lys Val Glu Tyr Ile Lys Ala Asp Lys Asn Gly Pro 
945                 950                 955                 960 


Ser Phe Gln Thr Ala Phe Gly Lys Thr Glu Gln Thr Val Lys Val Ala 
                965                 970                 975     


Phe Ser Ser Leu Asn Leu Leu Leu Gln Thr Gln Ala Leu Val Ala Ser 
            980                 985                 990         


Ile Asn Tyr Leu Thr Thr Ile Ile  Pro Ser Asp Asp Gln  Ser Ile Ser 
        995                 1000                 1005             


Val Ala  Lys Glu Val Gln Ile  Ser Thr Glu Lys Gln  Gln Lys Asn 
    1010                 1015                 1020             


Ser Thr  Leu Pro Lys Ala Ile  Val Ser Ser Arg Asp  Ser Asp Ile 
    1025                 1030                 1035             


Ile Asp  Phe Arg Leu Phe Ala  Lys Leu Asn Ala Phe  Cys Val Ile 
    1040                 1045                 1050             


Val Cys  Asn Glu Lys Asn Asn  Ile Ala Glu Ile Lys  Ile Gln Gly 
    1055                 1060                 1065             


Leu Asp  Ser Ser Leu Ser Leu  Gln Ser Arg Lys Gln  Ser Leu Phe 
    1070                 1075                 1080             


Ala Arg  Leu Glu Asn Ile Ile  Val Thr Asp Val Asp  Pro Lys Thr 
    1085                 1090                 1095             


Val His  Lys Lys Ala Val Ser  Ile Met Gly Asn Glu  Val Phe Arg 
    1100                 1105                 1110             


Phe Asn  Leu Asp Leu Tyr Pro  Asp Ala Thr Glu Gly  Asp Leu Tyr 
    1115                 1120                 1125             


Thr Asp  Met Ser Lys Val Asp  Gly Val Leu Ser Leu  Asn Val Gly 
    1130                 1135                 1140             


Cys Ile  Gln Ile Val Tyr Leu  His Lys Phe Leu Met  Ser Leu Leu 
    1145                 1150                 1155             


Asn Phe  Leu Asn Asn Phe Gln  Thr Ala Lys Glu Ser  Leu Ser Ala 
    1160                 1165                 1170             


Ala Thr  Ala Gln Ala Ala Glu  Arg Ala Ala Thr Ser  Val Lys Asp 
    1175                 1180                 1185             


Leu Ala  Gln Arg Ser Phe Arg  Val Ser Ile Asn Ile  Asp Leu Lys 
    1190                 1195                 1200             


Ala Pro  Val Ile Val Ile Pro  Gln Ser Ser Ile Ser  Thr Asn Ala 
    1205                 1210                 1215             


Val Val  Val Asp Leu Gly Leu  Ile Arg Val His Asn  Gln Phe Ser 
    1220                 1225                 1230             


Leu Val  Ser Asp Glu Asp Tyr  Leu Asn Pro Pro Val  Ile Asp Arg 
    1235                 1240                 1245             


Met Asp  Val Gln Leu Thr Lys  Leu Thr Leu Tyr Arg  Thr Val Ile 
    1250                 1255                 1260             


Gln Pro  Gly Ile Tyr His Pro  Asp Ile Gln Leu Leu  His Pro Ile 
    1265                 1270                 1275             


Asn Leu  Glu Phe Leu Val Asn  Arg Asn Leu Ala Ala  Ser Trp Tyr 
    1280                 1285                 1290             


His Lys  Val Pro Val Val Glu  Ile Lys Gly His Leu  Asp Ser Met 
    1295                 1300                 1305             


Asn Val  Ser Leu Asn Gln Glu  Asp Leu Asn Leu Leu  Phe Arg Ile 
    1310                 1315                 1320             


Leu Thr  Glu Asn Leu Cys Glu  Gly Thr Glu Asp Leu  Asp Lys Val 
    1325                 1330                 1335             


Lys Pro  Arg Val Gln Glu Thr  Gly Glu Ile Lys Glu  Pro Leu Glu 
    1340                 1345                 1350             


Ile Ser  Ile Ser Gln Asp Val  His Asp Ser Lys Asn  Thr Leu Thr 
    1355                 1360                 1365             


Thr Gly  Val Glu Glu Ile Arg  Ser Val Asp Ile Ile  Asn Met Leu 
    1370                 1375                 1380             


Leu Asn  Phe Glu Ile Lys Glu  Val Val Val Thr Leu  Met Lys Lys 
    1385                 1390                 1395             


Ser Glu  Lys Lys Gly Arg Pro  Leu His Glu Leu Asn  Val Leu Gln 
    1400                 1405                 1410             


Leu Gly  Met Glu Ala Lys Val  Lys Thr Tyr Asp Met  Thr Ala Lys 
    1415                 1420                 1425             


Ala Tyr  Leu Lys Lys Ile Ser  Met Gln Cys Phe Asp  Phe Thr Asp 
    1430                 1435                 1440             


Ser Lys  Gly Glu Pro Leu His  Ile Ile Asn Ser Ser  Asn Val Thr 
    1445                 1450                 1455             


Asp Glu  Pro Leu Leu Lys Met  Leu Leu Thr Lys Ala  Asp Ser Asp 
    1460                 1465                 1470             


Gly Pro  Glu Phe Lys Thr Ile  His Asp Ser Thr Lys  Gln Arg Leu 
    1475                 1480                 1485             


Lys Val  Ser Phe Ala Ser Leu  Asp Leu Val Leu His  Leu Glu Ala 
    1490                 1495                 1500             


Leu Leu  Ser Phe Met Asp Phe  Leu Ser Ser Ala Ala  Pro Phe Ser 
    1505                 1510                 1515             


Glu Pro  Ser Ser Ser Glu Lys  Glu Ser Glu Leu Lys  Pro Leu Val 
    1520                 1525                 1530             


Gly Glu  Ser Arg Ser Ile Ala  Val Lys Ala Val Ser  Ser Asn Ile 
    1535                 1540                 1545             


Ser Gln  Lys Asp Val Phe Asp  Leu Lys Ile Thr Ala  Glu Leu Asn 
    1550                 1555                 1560             


Ala Phe  Asn Val Phe Val Cys  Asp Gln Lys Cys Asn  Ile Ala Asp 
    1565                 1570                 1575             


Ile Lys  Ile His Gly Met Asp  Ala Ser Ile Ser Val  Lys Pro Lys 
    1580                 1585                 1590             


Gln Thr  Asp Val Phe Ala Arg  Leu Lys Asp Ile Ile  Val Met Asn 
    1595                 1600                 1605             


Val Asp  Leu Gln Ser Ile His  Lys Lys Ala Val Ser  Ile Leu Gly 
    1610                 1615                 1620             


Asp Glu  Val Phe Arg Phe Gln  Leu Thr Leu Tyr Pro  Asp Ala Thr 
    1625                 1630                 1635             


Glu Gly  Glu Ala Tyr Ala Asp  Met Ser Lys Val Asp  Gly Lys Leu 
    1640                 1645                 1650             


Ser Phe  Lys Val Gly Cys Ile  Gln Ile Val Tyr Val  His Lys Phe 
    1655                 1660                 1665             


Phe Met  Ser Leu Leu Asn Phe  Leu Asn Asn Phe Gln  Thr Ala Lys 
    1670                 1675                 1680             


Glu Ala  Leu Ser Thr Ala Thr  Val Gln Ala Ala Glu  Arg Ala Ala 
    1685                 1690                 1695             


Ser Ser  Met Lys Asp Leu Ala  Gln Lys Ser Phe Arg  Leu Leu Met 
    1700                 1705                 1710             


Asp Ile  Asn Leu Lys Ala Pro  Val Ile Ile Ile Pro  Gln Ser Ser 
    1715                 1720                 1725             


Val Ser  Pro Asn Ala Val Ile  Ala Asp Leu Gly Leu  Ile Arg Val 
    1730                 1735                 1740             


Glu Asn  Lys Phe Ser Leu Val  Pro Met Glu His Tyr  Ser Leu Pro 
    1745                 1750                 1755             


Pro Val  Ile Asp Lys Met Asn  Ile Glu Leu Thr Gln  Leu Lys Leu 
    1760                 1765                 1770             


Ser Arg  Thr Ile Leu Gln Ala  Ser Leu Pro Gln Asn  Asp Ile Glu 
    1775                 1780                 1785             


Ile Leu  Lys Pro Val Asn Met  Leu Leu Ser Ile Gln  Arg Asn Leu 
    1790                 1795                 1800             


Ala Ala  Ala Trp Tyr Val Gln  Ile Pro Gly Met Glu  Ile Lys Gly 
    1805                 1810                 1815             


Lys Leu  Lys Pro Met Gln Val  Ala Leu Ser Glu Asp  Asp Leu Thr 
    1820                 1825                 1830             


Val Leu  Met Lys Ile Leu Leu  Glu Asn Leu Gly Glu  Ala Ser Ser 
    1835                 1840                 1845             


Gln Pro  Ser Pro Thr Gln Ser  Val Gln Glu Thr Val  Arg Val Arg 
    1850                 1855                 1860             


Lys Val  Asp Val Ser Ser Val  Pro Asp His Leu Lys  Glu Gln Glu 
    1865                 1870                 1875             


Asp Trp  Thr Asp Ser Lys Leu  Ser Met Asn Gln Ile  Val Ser Leu 
    1880                 1885                 1890             


Gln Phe  Asp Phe His Phe Glu  Ser Leu Ser Ile Ile  Leu Tyr Asn 
    1895                 1900                 1905             


Asn Asp  Ile Asn Gln Glu Ser  Gly Val Ala Phe His  Asn Asp Ser 
    1910                 1915                 1920             


Phe Gln  Leu Gly Glu Leu Arg  Leu His Leu Met Ala  Ser Ser Gly 
    1925                 1930                 1935             


Lys Met  Phe Lys Asp Gly Ser  Met Asn Val Ser Val  Lys Leu Lys 
    1940                 1945                 1950             


Thr Cys  Thr Leu Asp Asp Leu  Arg Glu Gly Ile Glu  Arg Ala Thr 
    1955                 1960                 1965             


Ser Arg  Met Ile Asp Arg Lys  Asn Asp Gln Asp Asn  Asn Ser Ser 
    1970                 1975                 1980             


Met Ile  Asp Ile Ser Tyr Lys  Gln Asp Lys Asn Gly  Ser Gln Ile 
    1985                 1990                 1995             


Asp Ala  Val Leu Asp Lys Leu  Tyr Val Cys Ala Ser  Val Glu Phe 
    2000                 2005                 2010             


Leu Met  Thr Val Ala Asp Phe  Phe Ile Lys Ala Val  Pro Gln Ser 
    2015                 2020                 2025             


Pro Glu  Asn Val Ala Lys Glu  Thr Gln Ile Leu Pro  Arg Gln Thr 
    2030                 2035                 2040             


Ala Thr  Gly Lys Val Lys Ile  Glu Lys Asp Asp Ser  Val Arg Pro 
    2045                 2050                 2055             


Asn Met  Thr Leu Lys Ala Met  Ile Thr Asp Pro Glu  Val Val Phe 
    2060                 2065                 2070             


Val Ala  Ser Leu Thr Lys Ala  Asp Ala Pro Ala Leu  Thr Ala Ser 
    2075                 2080                 2085             


Phe Gln  Cys Asn Leu Ser Leu  Ser Thr Ser Lys Leu  Glu Gln Met 
    2090                 2095                 2100             


Met Glu  Ala Ser Val Arg Asp  Leu Lys Val Leu Ala  Cys Pro Phe 
    2105                 2110                 2115             


Leu Arg  Glu Lys Arg Gly Lys  Asn Ile Thr Thr Val  Leu Gln Pro 
    2120                 2125                 2130             


Cys Ser  Leu Phe Met Glu Lys  Cys Thr Trp Ala Ser  Gly Lys Gln 
    2135                 2140                 2145             


Asn Ile  Asn Ile Met Val Lys  Glu Phe Ile Ile Lys  Ile Ser Pro 
    2150                 2155                 2160             


Ile Ile  Leu Asn Thr Val Leu  Thr Ile Met Ala Ala  Leu Ser Pro 
    2165                 2170                 2175             


Lys Thr  Lys Glu Asp Gly Ser  Lys Asp Thr Ser Lys  Glu Met Glu 
    2180                 2185                 2190             


Asn Leu  Trp Gly Ile Lys Ser  Ile Asn Asp Tyr Asn  Thr Trp Phe 
    2195                 2200                 2205             


Leu Gly  Val Asp Thr Ala Thr  Glu Ile Thr Glu Ser  Phe Lys Gly 
    2210                 2215                 2220             


Ile Glu  His Ser Leu Ile Glu  Glu Asn Cys Gly Val  Val Val Glu 
    2225                 2230                 2235             


Ser Ile  Gln Val Thr Leu Glu  Cys Gly Leu Gly His  Arg Thr Val 
    2240                 2245                 2250             


Pro Leu  Leu Leu Ala Glu Ser  Lys Phe Ser Gly Asn  Ile Lys Asn 
    2255                 2260                 2265             


Trp Thr  Ser Leu Met Ala Ala  Val Ala Asp Val Thr  Leu Gln Val 
    2270                 2275                 2280             


His Tyr  Tyr Asn Glu Ile His  Ala Val Trp Glu Pro  Leu Ile Glu 
    2285                 2290                 2295             


Arg Val  Glu Gly Lys Arg Gln  Trp Asn Leu Arg Leu  Asp Val Lys 
    2300                 2305                 2310             


Lys Asn  Pro Val Gln Asp Lys  Ser Leu Leu Pro Gly  Asp Asp Phe 
    2315                 2320                 2325             


Ile Pro  Glu Pro Gln Met Ala  Ile His Ile Ser Ser  Gly Asn Thr 
    2330                 2335                 2340             


Met Asn  Ile Thr Ile Ser Lys  Ser Cys Leu Asn Val  Phe Asn Asn 
    2345                 2350                 2355             


Leu Ala  Lys Gly Phe Ser Glu  Gly Thr Ala Ser Thr  Phe Asp Tyr 
    2360                 2365                 2370             


Ser Leu  Lys Asp Arg Ala Pro  Phe Thr Val Lys Asn  Ala Val Gly 
    2375                 2380                 2385             


Val Pro  Ile Lys Val Lys Pro  Asn Cys Asn Leu Arg  Val Met Gly 
    2390                 2395                 2400             


Phe Pro  Glu Lys Ser Asp Ile  Phe Asp Val Asp Ala  Gly Gln Asn 
    2405                 2410                 2415             


Leu Glu  Leu Glu Tyr Ala Ser  Met Val Pro Ser Ser  Gln Gly Asn 
    2420                 2425                 2430             


Leu Ser  Ile Leu Ser Arg Gln  Glu Ser Ser Phe Phe  Thr Leu Thr 
    2435                 2440                 2445             


Ile Val  Pro His Gly Tyr Thr  Glu Val Ala Asn Ile  Pro Val Ala 
    2450                 2455                 2460             


Arg Pro  Gly Arg Arg Leu Tyr  Asn Val Arg Asn Pro  Asn Ala Ser 
    2465                 2470                 2475             


His Ser  Asp Ser Val Leu Val  Gln Ile Asp Ala Thr  Glu Gly Asn 
    2480                 2485                 2490             


Lys Val  Ile Thr Leu Arg Ser  Pro Leu Gln Ile Lys  Asn His Phe 
    2495                 2500                 2505             


Ser Ile  Ala Phe Ile Ile Tyr  Lys Phe Val Lys Asn  Val Lys Leu 
    2510                 2515                 2520             


Leu Glu  Arg Ile Gly Ile Ala  Arg Pro Glu Glu Glu  Phe His Val 
    2525                 2530                 2535             


Pro Leu  Asp Ser Tyr Arg Cys  Gln Leu Phe Ile Gln  Pro Ala Gly 
    2540                 2545                 2550             


Ile Leu  Glu His Gln Tyr Lys  Glu Ser Thr Thr Tyr  Ile Ser Trp 
    2555                 2560                 2565             


Lys Glu  Glu Leu His Arg Ser  Arg Glu Val Arg Cys  Met Leu Gln 
    2570                 2575                 2580             


Cys Pro  Ser Val Glu Val Ser  Phe Leu Pro Leu Ile  Val Asn Thr 
    2585                 2590                 2595             


Val Ala  Leu Pro Asp Glu Leu  Ser Tyr Ile Cys Thr  His Gly Glu 
    2600                 2605                 2610             


Asp Trp  Asp Val Ala Tyr Ile  Ile His Leu Tyr Pro  Ser Leu Thr 
    2615                 2620                 2625             


Leu Arg  Asn Leu Leu Pro Tyr  Ser Leu Arg Tyr Leu  Leu Glu Gly 
    2630                 2635                 2640             


Thr Ala  Glu Thr His Glu Leu  Ala Glu Gly Ser Thr  Ala Asp Val 
    2645                 2650                 2655             


Leu His  Ser Arg Ile Ser Gly  Glu Ile Met Glu Leu  Val Leu Val 
    2660                 2665                 2670             


Lys Tyr  Gln Gly Lys Asn Trp  Asn Gly His Phe Arg  Ile Arg Asp 
    2675                 2680                 2685             


Thr Leu  Pro Glu Phe Phe Pro  Val Cys Phe Ser Ser  Asp Ser Thr 
    2690                 2695                 2700             


Glu Val  Thr Thr Val Asp Leu  Ser Val His Val Arg  Arg Ile Gly 
    2705                 2710                 2715             


Ser Arg  Met Val Leu Ser Val  Phe Ser Pro Tyr Trp  Leu Ile Asn 
    2720                 2725                 2730             


Lys Thr  Thr Arg Val Leu Gln  Tyr Arg Ser Glu Asp  Ile His Val 
    2735                 2740                 2745             


Lys His  Pro Ala Asp Phe Arg  Asp Ile Ile Leu Phe  Ser Phe Lys 
    2750                 2755                 2760             


Lys Lys  Asn Ile Phe Thr Lys  Asn Lys Val Gln Leu  Lys Ile Ser 
    2765                 2770                 2775             


Thr Ser  Ala Trp Ser Ser Ser  Phe Ser Leu Asp Thr  Val Gly Ser 
    2780                 2785                 2790             


Tyr Gly  Cys Val Lys Cys Pro  Ala Asn Asn Met Glu  Tyr Leu Val 
    2795                 2800                 2805             


Gly Val  Ser Ile Lys Met Ser  Ser Phe Asn Leu Ser  Arg Ile Val 
    2810                 2815                 2820             


Thr Leu  Thr Pro Phe Cys Thr  Ile Ala Asn Lys Ser  Ser Leu Glu 
    2825                 2830                 2835             


Leu Glu  Val Gly Glu Ile Ala  Ser Asp Gly Ser Met  Pro Thr Asn 
    2840                 2845                 2850             


Lys Trp  Asn Tyr Ile Ala Ser  Ser Glu Cys Leu Pro  Phe Trp Pro 
    2855                 2860                 2865             


Glu Ser  Leu Ser Gly Lys Leu  Cys Val Arg Val Val  Gly Cys Glu 
    2870                 2875                 2880             


Gly Ser  Ser Lys Pro Phe Phe  Tyr Asn Arg Gln Asp  Asn Gly Thr 
    2885                 2890                 2895             


Leu Leu  Ser Leu Glu Asp Leu  Asn Gly Gly Ile Leu  Val Asp Val 
    2900                 2905                 2910             


Asn Thr  Ala Glu His Ser Thr  Val Ile Thr Phe Ser  Asp Tyr His 
    2915                 2920                 2925             


Glu Gly  Ser Ala Pro Ala Leu  Ile Met Asn His Thr  Pro Trp Asp 
    2930                 2935                 2940             


Ile Leu  Thr Tyr Lys Gln Ser  Gly Ser Pro Glu Glu  Met Val Leu 
    2945                 2950                 2955             


Leu Pro  Arg Gln Ala Arg Leu  Phe Ala Trp Ala Asp  Pro Thr Gly 
    2960                 2965                 2970             


Thr Arg  Lys Leu Thr Trp Thr  Tyr Ala Ala Asn Val  Gly Glu His 
    2975                 2980                 2985             


Asp Leu  Leu Lys Asp Gly Cys  Gly Gln Phe Pro Tyr  Asp Ala Asn 
    2990                 2995                 3000             


Ile Gln  Ile His Trp Val Ser  Phe Leu Asp Gly Arg  Gln Arg Val 
    3005                 3010                 3015             


Leu Leu  Phe Thr Asp Asp Val  Ala Leu Val Ser Lys  Ala Leu Gln 
    3020                 3025                 3030             


Ala Glu  Glu Met Glu Gln Ala  Asp Tyr Glu Ile Thr  Leu Ser Leu 
    3035                 3040                 3045             


His Ser  Leu Gly Leu Ser Leu  Val Asn Asn Glu Ser  Lys Gln Glu 
    3050                 3055                 3060             


Val Ser  Tyr Ile Gly Ile Thr  Ser Ser Gly Val Val  Trp Glu Val 
    3065                 3070                 3075             


Lys Pro  Lys Gln Lys Trp Lys  Pro Phe Ser Gln Lys  Gln Ile Ile 
    3080                 3085                 3090             


Leu Leu  Glu Gln Ser Tyr Gln  Lys His Gln Ile Ser  Arg Asp His 
    3095                 3100                 3105             


Gly Trp  Ile Lys Leu Asp Asn  Asn Phe Glu Val Asn  Phe Asp Lys 
    3110                 3115                 3120             


Asp Pro  Met Glu Met Arg Leu  Pro Ile Arg Ser Pro  Ile Lys Arg 
    3125                 3130                 3135             


Asp Phe  Leu Ser Gly Ile Gln  Ile Glu Phe Lys Gln  Ser Ser His 
    3140                 3145                 3150             


Gln Arg  Ser Leu Arg Ala Arg  Leu Tyr Trp Leu Gln  Val Asp Asn 
    3155                 3160                 3165             


Gln Leu  Pro Gly Ala Met Phe  Pro Val Val Phe His  Pro Val Ala 
    3170                 3175                 3180             


Pro Pro  Lys Ser Ile Ala Leu  Asp Ser Glu Pro Lys  Pro Phe Ile 
    3185                 3190                 3195             


Asp Val  Ser Val Ile Thr Arg  Phe Asn Glu Tyr Ser  Lys Val Leu 
    3200                 3205                 3210             


Gln Phe  Lys Tyr Phe Met Val  Leu Ile Gln Glu Met  Ala Leu Lys 
    3215                 3220                 3225             


Ile Asp  Gln Gly Phe Leu Gly  Ala Ile Ile Ala Leu  Phe Thr Pro 
    3230                 3235                 3240             


Thr Thr  Asp Pro Glu Ala Glu  Arg Arg Arg Thr Lys  Leu Ile Gln 
    3245                 3250                 3255             


Gln Asp  Ile Asp Ala Leu Asn  Ala Glu Leu Met Glu  Thr Ser Met 
    3260                 3265                 3270             


Thr Asp  Met Ser Ile Leu Ser  Phe Phe Glu His Phe  His Ile Ser 
    3275                 3280                 3285             


Pro Val  Lys Leu His Leu Ser  Leu Ser Leu Gly Ser  Gly Gly Glu 
    3290                 3295                 3300             


Glu Ser  Asp Lys Glu Lys Gln  Glu Met Phe Ala Val  His Ser Val 
    3305                 3310                 3315             


Asn Leu  Leu Leu Lys Ser Ile  Gly Ala Thr Leu Thr  Asp Val Asp 
    3320                 3325                 3330             


Asp Leu  Ile Phe Lys Leu Ala  Tyr Tyr Glu Ile Arg  Tyr Gln Phe 
    3335                 3340                 3345             


Tyr Lys  Arg Asp Gln Leu Ile  Trp Ser Val Val Arg  His Tyr Ser 
    3350                 3355                 3360             


Glu Gln  Phe Leu Lys Gln Met  Tyr Val Leu Val Leu  Gly Leu Asp 
    3365                 3370                 3375             


Val Leu  Gly Asn Pro Phe Gly  Leu Ile Arg Gly Leu  Ser Glu Gly 
    3380                 3385                 3390             


Val Glu  Ala Leu Phe Tyr Glu  Pro Phe Gln Gly Ala  Val Gln Gly 
    3395                 3400                 3405             


Pro Glu  Glu Phe Ala Glu Gly  Leu Val Ile Gly Val  Arg Ser Leu 
    3410                 3415                 3420             


Phe Gly  His Thr Val Gly Gly  Ala Ala Gly Val Val  Ser Arg Ile 
    3425                 3430                 3435             


Thr Gly  Ser Val Gly Lys Gly  Leu Ala Ala Ile Thr  Met Asp Lys 
    3440                 3445                 3450             


Glu Tyr  Gln Gln Lys Arg Arg  Glu Glu Leu Ser Arg  Gln Pro Arg 
    3455                 3460                 3465             


Asp Phe  Gly Asp Ser Leu Ala  Arg Gly Gly Lys Gly  Phe Leu Arg 
    3470                 3475                 3480             


Gly Val  Val Gly Gly Val Thr  Gly Ile Ile Thr Lys  Pro Val Glu 
    3485                 3490                 3495             


Gly Ala  Lys Lys Glu Gly Ala  Ala Gly Phe Phe Lys  Gly Ile Gly 
    3500                 3505                 3510             


Lys Gly  Leu Val Gly Ala Val  Ala Arg Pro Thr Gly  Gly Ile Val 
    3515                 3520                 3525             


Asp Met  Ala Ser Ser Thr Phe  Gln Gly Ile Gln Arg  Ala Ala Glu 
    3530                 3535                 3540             


Ser Thr  Glu Glu Val Ser Ser  Leu Arg Pro Pro Arg  Leu Ile His 
    3545                 3550                 3555             


Glu Asp  Gly Ile Ile Arg Pro  Tyr Asp Arg Gln Glu  Ser Glu Gly 
    3560                 3565                 3570             


Ser Asp  Leu Leu Glu Asn His  Ile Lys Lys Leu Glu  Gly Glu Thr 
    3575                 3580                 3585             


Tyr Arg  Tyr His Cys Ala Ile  Pro Gly Ser Lys Lys  Thr Ile Leu 
    3590                 3595                 3600             


Met Val  Thr Asn Arg Arg Val  Leu Cys Ile Lys Glu  Val Glu Ile 
    3605                 3610                 3615             


Leu Gly  Leu Met Cys Val Asp  Trp Gln Cys Pro Phe  Glu Asp Phe 
    3620                 3625                 3630             


Val Phe  Pro Pro Ser Val Ser  Glu Asn Val Leu Lys  Ile Ser Val 
    3635                 3640                 3645             


Lys Glu  Gln Gly Leu Phe His  Lys Lys Asp Ser Ala  Asn Gln Gly 
    3650                 3655                 3660             


Cys Val  Arg Lys Val Tyr Leu  Lys Asp Thr Ala Thr  Ala Glu Arg 
    3665                 3670                 3675             


Ala Cys  Asn Ala Ile Glu Asp  Ala Gln Ser Thr Arg  Gln Gln Gln 
    3680                 3685                 3690             


Lys Leu  Met Lys Gln Ser Ser  Val Arg Leu Leu Arg  Pro Gln Leu 
    3695                 3700                 3705             


Pro Ser  
    3710 


<210>  1569
<211>  654
<212>  PRT
<213>  homo sapiens

<400>  1569

Met Glu Arg Ser Gly Pro Ser Glu Val Thr Gly Ser Asp Ala Ser Gly 
1               5                   10                  15      


Pro Asp Pro Gln Leu Ala Val Thr Met Gly Phe Thr Gly Phe Gly Lys 
            20                  25                  30          


Lys Ala Arg Thr Phe Asp Leu Glu Ala Met Phe Glu Gln Thr Arg Arg 
        35                  40                  45              


Thr Ala Val Glu Arg Ser Arg Lys Thr Leu Glu Ala Arg Glu Lys Glu 
    50                  55                  60                  


Glu Glu Met Asn Arg Glu Lys Glu Leu Arg Arg Gln Asn Glu Asp Ile 
65                  70                  75                  80  


Glu Pro Thr Ser Ser Arg Ser Asn Val Val Arg Asp Cys Ser Lys Ser 
                85                  90                  95      


Ser Ser Arg Asp Thr Ser Ser Ser Glu Ser Glu Gln Ser Ser Asp Ser 
            100                 105                 110         


Ser Asp Asp Glu Leu Ile Gly Pro Pro Leu Pro Pro Lys Met Val Gly 
        115                 120                 125             


Lys Pro Val Asn Phe Met Glu Glu Asp Ile Leu Gly Pro Leu Pro Pro 
    130                 135                 140                 


Pro Leu Asn Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Asn Pro Val His Lys Ile Pro Asp Ser His Glu Ile 
                165                 170                 175     


Thr Leu Lys His Gly Thr Lys Thr Val Ser Ala Leu Gly Leu Asp Pro 
            180                 185                 190         


Ser Gly Ala Arg Leu Val Thr Gly Gly Tyr Asp Tyr Asp Val Lys Phe 
        195                 200                 205             


Trp Asp Phe Ala Gly Met Asp Ala Ser Phe Lys Ala Phe Arg Ser Leu 
    210                 215                 220                 


Gln Pro Cys Glu Cys His Gln Ile Lys Ser Leu Gln Tyr Ser Asn Thr 
225                 230                 235                 240 


Gly Asp Met Ile Leu Val Val Ser Gly Ser Ser Gln Ala Lys Val Ile 
                245                 250                 255     


Asp Arg Asp Gly Phe Glu Val Met Glu Cys Ile Lys Gly Asp Gln Tyr 
            260                 265                 270         


Ile Val Asp Met Ala Asn Thr Lys Gly His Thr Ala Met Leu His Thr 
        275                 280                 285             


Gly Ser Trp His Pro Lys Ile Lys Gly Glu Phe Met Thr Cys Ser Asn 
    290                 295                 300                 


Asp Ala Thr Val Arg Thr Trp Glu Val Glu Asn Pro Lys Lys Gln Lys 
305                 310                 315                 320 


Ser Val Phe Lys Pro Arg Thr Met Gln Gly Lys Lys Val Ile Pro Thr 
                325                 330                 335     


Thr Cys Thr Tyr Ser Arg Asp Gly Asn Leu Ile Ala Ala Ala Cys Gln 
            340                 345                 350         


Asn Gly Ser Ile Gln Ile Trp Asp Arg Asn Leu Thr Val His Pro Lys 
        355                 360                 365             


Phe His Tyr Lys Gln Ala His Asp Ser Gly Thr Asp Thr Ser Cys Val 
    370                 375                 380                 


Thr Phe Ser Tyr Asp Gly Asn Val Leu Ala Ser Arg Gly Gly Asp Asp 
385                 390                 395                 400 


Ser Leu Lys Leu Trp Asp Ile Arg Gln Phe Asn Lys Pro Leu Phe Ser 
                405                 410                 415     


Ala Ser Gly Leu Pro Thr Met Phe Pro Met Thr Asp Cys Cys Phe Ser 
            420                 425                 430         


Pro Asp Asp Lys Leu Ile Val Thr Gly Thr Ser Ile Gln Arg Gly Cys 
        435                 440                 445             


Gly Ser Gly Lys Leu Val Phe Phe Glu Arg Arg Thr Phe Gln Arg Val 
    450                 455                 460                 


Tyr Glu Ile Asp Ile Thr Asp Ala Ser Val Val Arg Cys Leu Trp His 
465                 470                 475                 480 


Pro Lys Leu Asn Gln Ile Met Val Gly Thr Gly Asn Gly Leu Ala Lys 
                485                 490                 495     


Val Tyr Tyr Asp Pro Asn Lys Ser Gln Arg Gly Ala Lys Leu Cys Val 
            500                 505                 510         


Val Lys Thr Gln Arg Lys Ala Lys Gln Ala Glu Thr Leu Thr Gln Asp 
        515                 520                 525             


Tyr Ile Ile Thr Pro His Ala Leu Pro Met Phe Arg Glu Pro Arg Gln 
    530                 535                 540                 


Arg Ser Thr Arg Lys Gln Leu Glu Lys Asp Arg Leu Asp Pro Leu Lys 
545                 550                 555                 560 


Ser His Lys Pro Glu Pro Pro Val Ala Gly Pro Gly Arg Gly Gly Arg 
                565                 570                 575     


Val Gly Thr His Gly Gly Thr Leu Ser Ser Tyr Ile Val Lys Asn Ile 
            580                 585                 590         


Ala Leu Asp Lys Thr Asp Asp Ser Asn Pro Arg Glu Ala Ile Leu Arg 
        595                 600                 605             


His Ala Lys Ala Ala Glu Asp Ser Pro Tyr Trp Val Ser Pro Ala Tyr 
    610                 615                 620                 


Ser Lys Thr Gln Pro Lys Thr Met Phe Ala Gln Val Glu Ser Asp Asp 
625                 630                 635                 640 


Glu Glu Ala Lys Asn Glu Pro Glu Trp Lys Lys Arg Lys Ile 
                645                 650                 


<210>  1570
<211>  1151
<212>  PRT
<213>  homo sapiens

<400>  1570

Met Met Ala Ala Ala Leu Gly Pro Pro Glu Val Ile Ala Gln Leu Glu 
1               5                   10                  15      


Asn Ala Ala Lys Val Leu Met Ala Pro Pro Ser Met Val Asn Asn Glu 
            20                  25                  30          


Gln Arg Gln His Ala Glu His Ile Phe Leu Ser Phe Arg Lys Ser Lys 
        35                  40                  45              


Ser Pro Phe Ala Val Cys Lys His Ile Leu Glu Thr Ser Lys Val Asp 
    50                  55                  60                  


Tyr Val Leu Phe Gln Ala Ala Thr Ala Ile Met Glu Ala Val Val Arg 
65                  70                  75                  80  


Glu Trp Ile Leu Leu Glu Lys Gly Ser Ile Glu Ser Leu Arg Thr Phe 
                85                  90                  95      


Leu Leu Thr Tyr Val Leu Gln Arg Pro Asn Leu Gln Lys Tyr Val Arg 
            100                 105                 110         


Glu Gln Ile Leu Leu Ala Val Ala Val Ile Val Lys Arg Gly Ser Leu 
        115                 120                 125             


Asp Lys Ser Ile Asp Cys Lys Ser Ile Phe His Glu Val Ser Gln Leu 
    130                 135                 140                 


Ile Ser Ser Gly Asn Pro Thr Val Gln Thr Leu Ala Cys Ser Ile Leu 
145                 150                 155                 160 


Thr Ala Leu Leu Ser Glu Phe Ser Ser Ser Ser Lys Thr Ser Asn Ile 
                165                 170                 175     


Gly Leu Ser Met Glu Phe His Gly Asn Cys Lys Arg Val Phe Gln Glu 
            180                 185                 190         


Glu Asp Leu Arg Gln Ile Phe Met Leu Thr Val Glu Val Leu Gln Glu 
        195                 200                 205             


Phe Ser Arg Arg Glu Asn Leu Asn Ala Gln Met Ser Ser Val Phe Gln 
    210                 215                 220                 


Arg Tyr Leu Ala Leu Ala Asn Gln Val Leu Ser Trp Asn Phe Leu Pro 
225                 230                 235                 240 


Pro Asn Leu Gly Arg His Tyr Ile Ala Met Phe Glu Ser Ser Gln Asn 
                245                 250                 255     


Val Leu Leu Lys Pro Thr Glu Ser Trp Arg Glu Thr Leu Leu Asp Ser 
            260                 265                 270         


Arg Val Met Glu Leu Phe Phe Thr Val His Arg Lys Ile Arg Glu Asp 
        275                 280                 285             


Ser Asp Met Ala Gln Asp Ser Leu Gln Cys Leu Ala Gln Leu Ala Ser 
    290                 295                 300                 


Leu His Gly Pro Ile Phe Pro Asp Glu Gly Ser Gln Val Asp Tyr Leu 
305                 310                 315                 320 


Ala His Phe Ile Glu Gly Leu Leu Asn Thr Ile Asn Gly Ile Glu Ile 
                325                 330                 335     


Glu Asp Ser Glu Ala Val Gly Ile Ser Ser Ile Ile Ser Asn Leu Ile 
            340                 345                 350         


Thr Val Phe Pro Arg Asn Val Leu Thr Ala Ile Pro Ser Glu Leu Phe 
        355                 360                 365             


Ser Ser Phe Val Asn Cys Leu Thr His Leu Thr Cys Ser Phe Gly Arg 
    370                 375                 380                 


Ser Ala Ala Leu Glu Glu Val Leu Asp Lys Asp Asp Met Val Tyr Met 
385                 390                 395                 400 


Glu Ala Tyr Asp Lys Leu Leu Glu Ser Trp Leu Thr Leu Val Gln Asp 
                405                 410                 415     


Asp Lys His Phe His Lys Gly Phe Phe Thr Gln His Ala Val Gln Val 
            420                 425                 430         


Phe Asn Ser Tyr Ile Gln Cys His Leu Ala Ala Pro Asp Gly Thr Arg 
        435                 440                 445             


Asn Leu Thr Ala Asn Gly Val Ala Ser Arg Glu Glu Glu Glu Ile Ser 
    450                 455                 460                 


Glu Leu Gln Glu Asp Asp Arg Asp Gln Phe Ser Asp Gln Leu Ala Ser 
465                 470                 475                 480 


Val Gly Met Leu Gly Arg Ile Ala Ala Glu His Cys Ile Pro Leu Leu 
                485                 490                 495     


Thr Ser Leu Leu Glu Glu Arg Val Thr Arg Leu His Gly Gln Leu Gln 
            500                 505                 510         


Arg His Gln Gln Gln Leu Leu Ala Ser Pro Gly Ser Ser Thr Val Asp 
        515                 520                 525             


Asn Lys Met Leu Asp Asp Leu Tyr Glu Asp Ile His Trp Leu Ile Leu 
    530                 535                 540                 


Val Thr Gly Tyr Leu Leu Ala Asp Asp Thr Gln Gly Glu Thr Pro Leu 
545                 550                 555                 560 


Ile Pro Pro Glu Ile Met Glu Tyr Ser Ile Lys His Ser Ser Glu Val 
                565                 570                 575     


Asp Ile Asn Thr Thr Leu Gln Ile Leu Gly Ser Pro Gly Glu Lys Ala 
            580                 585                 590         


Ser Ser Ile Pro Gly Tyr Asn Arg Thr Asp Ser Val Ile Arg Leu Leu 
        595                 600                 605             


Ser Ala Ile Leu Arg Val Ser Glu Val Glu Ser Arg Ala Ile Arg Ala 
    610                 615                 620                 


Asp Leu Thr His Leu Leu Ser Pro Gln Met Gly Lys Asp Ile Val Trp 
625                 630                 635                 640 


Phe Leu Lys Arg Trp Ala Lys Thr Tyr Leu Leu Val Asp Glu Lys Leu 
                645                 650                 655     


Tyr Asp Gln Ile Ser Leu Pro Phe Ser Thr Ala Phe Gly Ala Asp Thr 
            660                 665                 670         


Glu Gly Ser Gln Trp Ile Ile Gly Tyr Leu Leu Gln Lys Val Ile Ser 
        675                 680                 685             


Asn Leu Ser Val Trp Ser Ser Glu Gln Asp Leu Ala Asn Asp Thr Val 
    690                 695                 700                 


Gln Leu Leu Val Thr Leu Val Glu Arg Arg Glu Arg Ala Asn Leu Val 
705                 710                 715                 720 


Ile Gln Cys Glu Asn Trp Trp Asn Leu Ala Lys Gln Phe Ala Ser Arg 
                725                 730                 735     


Ser Pro Pro Leu Asn Phe Leu Ser Ser Pro Val Gln Arg Thr Leu Met 
            740                 745                 750         


Lys Ala Leu Val Leu Gly Gly Phe Ala His Met Asp Thr Glu Thr Lys 
        755                 760                 765             


Gln Gln Tyr Trp Thr Glu Val Leu Gln Pro Leu Gln Gln Arg Phe Leu 
    770                 775                 780                 


Arg Val Ile Asn Gln Glu Asn Phe Gln Gln Met Cys Gln Gln Glu Glu 
785                 790                 795                 800 


Val Lys Gln Glu Ile Thr Ala Thr Leu Glu Ala Leu Cys Gly Ile Ala 
                805                 810                 815     


Glu Ala Thr Gln Ile Asp Asn Val Ala Ile Leu Phe Asn Phe Leu Met 
            820                 825                 830         


Asp Phe Leu Thr Asn Cys Ile Gly Leu Met Glu Val Tyr Lys Asn Thr 
        835                 840                 845             


Pro Glu Thr Val Asn Leu Ile Ile Glu Val Phe Val Glu Val Ala His 
    850                 855                 860                 


Lys Gln Ile Cys Tyr Leu Gly Glu Ser Lys Ala Met Asn Leu Tyr Glu 
865                 870                 875                 880 


Ala Cys Leu Thr Leu Leu Gln Val Tyr Ser Lys Asn Asn Leu Gly Arg 
                885                 890                 895     


Gln Arg Ile Asp Val Thr Ala Glu Glu Glu Gln Tyr Gln Asp Leu Leu 
            900                 905                 910         


Leu Ile Met Glu Leu Leu Thr Asn Leu Leu Ser Lys Glu Phe Ile Asp 
        915                 920                 925             


Phe Ser Asp Thr Asp Glu Val Phe Arg Gly His Glu Pro Gly Gln Ala 
    930                 935                 940                 


Ala Asn Arg Ser Val Ser Ala Ala Asp Val Val Leu Tyr Gly Val Asn 
945                 950                 955                 960 


Leu Ile Leu Pro Leu Met Ser Gln Asp Leu Leu Lys Phe Pro Thr Leu 
                965                 970                 975     


Cys Asn Gln Tyr Tyr Lys Leu Ile Thr Phe Ile Cys Glu Ile Phe Pro 
            980                 985                 990         


Glu Lys Ile Pro Gln Leu Pro Glu  Asp Leu Phe Lys Ser  Leu Met Tyr 
        995                 1000                 1005             


Ser Leu  Glu Leu Gly Met Thr  Ser Met Ser Ser Glu  Val Cys Gln 
    1010                 1015                 1020             


Leu Cys  Leu Glu Ala Leu Thr  Pro Leu Ala Glu Gln  Cys Ala Lys 
    1025                 1030                 1035             


Ala Gln  Glu Thr Asp Ser Pro  Leu Phe Leu Ala Thr  Arg His Phe 
    1040                 1045                 1050             


Leu Lys  Leu Val Phe Asp Met  Leu Val Leu Gln Lys  His Asn Thr 
    1055                 1060                 1065             


Glu Met  Thr Thr Ala Ala Gly  Glu Ala Phe Tyr Thr  Leu Val Cys 
    1070                 1075                 1080             


Leu His  Gln Ala Glu Tyr Ser  Glu Leu Val Glu Thr  Leu Leu Ser 
    1085                 1090                 1095             


Ser Gln  Gln Asp Pro Val Ile  Tyr Gln Arg Leu Ala  Asp Ala Phe 
    1100                 1105                 1110             


Asn Lys  Leu Thr Ala Ser Ser  Thr Pro Pro Thr Leu  Asp Arg Lys 
    1115                 1120                 1125             


Gln Lys  Met Ala Phe Leu Lys  Ser Leu Glu Glu Phe  Met Ala Asn 
    1130                 1135                 1140             


Val Gly  Gly Leu Leu Cys Val  Lys 
    1145                 1150     


<210>  1571
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  1571

Met Phe Lys Arg Met Ala Glu Phe Gly Pro Asp Ser Gly Gly Arg Val 
1               5                   10                  15      


Lys Gly Val Thr Ile Val Lys Pro Ile Val Tyr Gly Asn Val Ala Arg 
            20                  25                  30          


Tyr Phe Gly Lys Lys Arg Glu Glu Asp Gly His Thr His Gln Trp Thr 
        35                  40                  45              


Val Tyr Val Lys Pro Tyr Arg Asn Glu Asp Met Ser Ala Tyr Val Lys 
    50                  55                  60                  


Lys Ile Gln Phe Lys Leu His Glu Ser Tyr Gly Asn Pro Leu Arg Val 
65                  70                  75                  80  


Val Thr Lys Pro Pro Tyr Glu Ile Thr Glu Thr Gly Trp Gly Glu Phe 
                85                  90                  95      


Glu Ile Ile Ile Lys Ile Phe Phe Ile Asp Pro Asn Glu Arg Pro Val 
            100                 105                 110         


Thr Leu Tyr His Leu Leu Lys Leu Phe Gln Ser Asp Thr Asn Ala Met 
        115                 120                 125             


Leu Gly Lys Lys Thr Val Val Ser Glu Phe Tyr Asp Glu Met Ile Phe 
    130                 135                 140                 


Gln Asp Pro Thr Ala Met Met Gln Gln Leu Leu Thr Thr Ser Arg Gln 
145                 150                 155                 160 


Leu Thr Leu Gly Ala Tyr Lys His Glu Thr Glu Phe Ala Glu Leu Glu 
                165                 170                 175     


Val Lys Thr Arg Glu Lys Leu Glu Ala Ala Lys Lys Lys Thr Ser Phe 
            180                 185                 190         


Glu Ile Ala Glu Leu Lys Glu Arg Leu Lys Ala Ser Arg Glu Thr Ile 
        195                 200                 205             


Asn Cys Leu Lys Asn Glu Ile Arg Lys Leu Glu Glu Asp Asp Gln Ala 
    210                 215                 220                 


Lys Asp Ile 
225         


<210>  1572
<211>  1430
<212>  PRT
<213>  homo sapiens

<400>  1572

Met Ser Arg Pro Ser Ser Val Ser Pro Arg Gln Pro Ala Pro Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Pro Ser Pro Cys Gly Pro Gly Gly Gly Gly Arg 
            20                  25                  30          


Ala Lys Gly Leu Lys Asp Ile Arg Ile Asp Glu Glu Val Lys Ile Ala 
        35                  40                  45              


Val Asn Ile Ala Leu Glu Arg Phe Arg Tyr Gly Asp Gln Arg Glu Met 
    50                  55                  60                  


Glu Phe Pro Ser Ser Leu Thr Ser Thr Glu Arg Ala Phe Ile His Arg 
65                  70                  75                  80  


Leu Ser Gln Ser Leu Gly Leu Val Ser Lys Ser Lys Gly Lys Gly Ala 
                85                  90                  95      


Asn Arg Tyr Leu Thr Val Lys Lys Lys Asp Gly Ser Glu Thr Ala His 
            100                 105                 110         


Ala Met Met Thr Cys Asn Leu Thr His Asn Thr Lys His Ala Val Arg 
        115                 120                 125             


Ser Leu Ile Gln Arg Phe Pro Val Thr Asn Lys Glu Arg Thr Glu Leu 
    130                 135                 140                 


Leu Pro Lys Thr Glu Arg Gly Asn Val Phe Ala Val Glu Ala Glu Asn 
145                 150                 155                 160 


Arg Glu Met Ser Lys Thr Ser Gly Arg Leu Asn Asn Gly Ile Pro Gln 
                165                 170                 175     


Ile Pro Val Lys Arg Gly Glu Ser Glu Phe Asp Ser Phe Arg Gln Ser 
            180                 185                 190         


Leu Pro Val Phe Glu Lys Gln Glu Glu Ile Val Lys Ile Ile Lys Glu 
        195                 200                 205             


Asn Lys Val Val Leu Ile Val Gly Glu Thr Gly Ser Gly Lys Thr Thr 
    210                 215                 220                 


Gln Ile Pro Gln Phe Leu Leu Asp Asp Cys Phe Lys Asn Gly Ile Pro 
225                 230                 235                 240 


Cys Arg Ile Phe Cys Thr Gln Pro Arg Arg Leu Ala Ala Ile Ala Val 
                245                 250                 255     


Ala Glu Arg Val Ala Ala Glu Arg Arg Glu Arg Ile Gly Gln Thr Ile 
            260                 265                 270         


Gly Tyr Gln Ile Arg Leu Glu Ser Arg Val Ser Pro Lys Thr Leu Leu 
        275                 280                 285             


Thr Phe Cys Thr Asn Gly Val Leu Leu Arg Thr Leu Met Ala Gly Asp 
    290                 295                 300                 


Ser Thr Leu Ser Thr Val Thr His Val Ile Val Asp Glu Val His Glu 
305                 310                 315                 320 


Arg Asp Arg Phe Ser Asp Phe Leu Leu Thr Lys Leu Arg Asp Leu Leu 
                325                 330                 335     


Gln Lys His Pro Thr Leu Lys Leu Ile Leu Ser Ser Ala Ala Leu Asp 
            340                 345                 350         


Val Asn Leu Phe Ile Arg Tyr Phe Gly Ser Cys Pro Val Ile Tyr Ile 
        355                 360                 365             


Gln Gly Arg Pro Phe Glu Val Lys Glu Met Phe Leu Glu Asp Ile Leu 
    370                 375                 380                 


Arg Thr Thr Gly Tyr Thr Asn Lys Glu Met Leu Lys Tyr Lys Lys Glu 
385                 390                 395                 400 


Lys Gln Gln Glu Glu Lys Gln Gln Thr Thr Leu Thr Glu Trp Tyr Ser 
                405                 410                 415     


Ala Gln Glu Asn Ser Phe Lys Pro Glu Ser Gln Arg Gln Arg Thr Val 
            420                 425                 430         


Leu Asn Val Thr Asp Glu Tyr Asp Leu Leu Asp Asp Gly Gly Asp Ala 
        435                 440                 445             


Val Phe Ser Gln Leu Thr Glu Lys Asp Val Asn Cys Leu Glu Pro Trp 
    450                 455                 460                 


Leu Ile Lys Glu Met Asp Ala Cys Leu Ser Asp Ile Trp Leu His Lys 
465                 470                 475                 480 


Asp Ile Asp Ala Phe Ala Gln Val Phe His Leu Ile Leu Thr Glu Asn 
                485                 490                 495     


Val Ser Val Asp Tyr Arg His Ser Glu Thr Ser Ala Thr Ala Leu Met 
            500                 505                 510         


Val Ala Ala Gly Arg Gly Phe Ala Ser Gln Val Glu Gln Leu Ile Ser 
        515                 520                 525             


Met Gly Ala Asn Val His Ser Lys Ala Ser Asn Gly Trp Met Ala Leu 
    530                 535                 540                 


Asp Trp Ala Lys His Phe Gly Gln Thr Glu Ile Val Asp Leu Leu Glu 
545                 550                 555                 560 


Ser Tyr Ser Ala Thr Leu Glu Phe Gly Asn Leu Asp Glu Ser Ser Leu 
                565                 570                 575     


Val Gln Thr Asn Gly Ser Asp Leu Ser Ala Glu Asp Arg Glu Leu Leu 
            580                 585                 590         


Lys Ala Tyr His His Ser Phe Asp Asp Glu Lys Val Asp Leu Asp Leu 
        595                 600                 605             


Ile Met His Leu Leu Tyr Asn Ile Cys His Ser Cys Asp Ala Gly Ala 
    610                 615                 620                 


Val Leu Ile Phe Leu Pro Gly Tyr Asp Glu Ile Val Gly Leu Arg Asp 
625                 630                 635                 640 


Arg Ile Leu Phe Asp Asp Lys Arg Phe Ala Asp Ser Thr His Arg Tyr 
                645                 650                 655     


Gln Val Phe Met Leu His Ser Asn Met Gln Thr Ser Asp Gln Lys Lys 
            660                 665                 670         


Val Leu Lys Asn Pro Pro Ala Gly Val Arg Lys Ile Ile Leu Ser Thr 
        675                 680                 685             


Asn Ile Ala Glu Thr Ser Ile Thr Val Asn Asp Val Val Phe Val Ile 
    690                 695                 700                 


Asp Ser Gly Lys Val Lys Glu Lys Ser Phe Asp Ala Leu Asn Phe Val 
705                 710                 715                 720 


Thr Met Leu Lys Met Val Trp Ile Ser Lys Ala Ser Ala Ile Gln Arg 
                725                 730                 735     


Lys Gly Arg Ala Gly Arg Cys Arg Pro Gly Ile Cys Phe Arg Leu Phe 
            740                 745                 750         


Ser Arg Leu Arg Phe Gln Asn Met Leu Glu Phe Gln Thr Pro Glu Leu 
        755                 760                 765             


Leu Arg Met Pro Leu Gln Glu Leu Cys Leu His Thr Lys Leu Leu Ala 
    770                 775                 780                 


Pro Val Asn Cys Pro Ile Ala Asp Phe Leu Met Lys Ala Pro Glu Pro 
785                 790                 795                 800 


Pro Pro Ala Leu Ile Val Arg Asn Ala Val Gln Met Leu Lys Thr Ile 
                805                 810                 815     


Asp Ala Met Asp Thr Trp Glu Asp Leu Thr Glu Leu Gly Tyr His Leu 
            820                 825                 830         


Ala Asp Leu Pro Val Glu Pro His Leu Gly Lys Met Val Leu Cys Ala 
        835                 840                 845             


Val Val Leu Lys Cys Leu Asp Pro Ile Leu Thr Ile Ala Cys Thr Leu 
    850                 855                 860                 


Ala Tyr Arg Asp Pro Phe Val Leu Pro Thr Gln Ala Ser Gln Lys Arg 
865                 870                 875                 880 


Ala Ala Met Leu Cys Arg Lys Arg Phe Thr Ala Gly Ala Phe Ser Asp 
                885                 890                 895     


His Met Ala Leu Leu Arg Ala Phe Gln Ala Trp Gln Lys Ala Arg Ser 
            900                 905                 910         


Asp Gly Trp Glu Arg Ala Phe Cys Glu Lys Asn Phe Leu Ser Gln Ala 
        915                 920                 925             


Thr Met Glu Ile Ile Ile Gly Met Arg Thr Gln Leu Leu Gly Gln Leu 
    930                 935                 940                 


Arg Ala Ser Gly Phe Val Arg Ala Arg Gly Gly Gly Asp Ile Arg Asp 
945                 950                 955                 960 


Val Asn Thr Asn Ser Glu Asn Trp Ala Val Val Lys Ala Ala Leu Val 
                965                 970                 975     


Ala Gly Met Tyr Pro Asn Leu Val His Val Asp Arg Glu Asn Leu Val 
            980                 985                 990         


Leu Thr Gly Pro Lys Glu Lys Lys  Val Arg Phe His Pro  Ala Ser Val 
        995                 1000                 1005             


Leu Ser  Gln Pro Gln Tyr Lys  Lys Ile Pro Pro Ala  Asn Gly Gln 
    1010                 1015                 1020             


Ala Ala  Ala Ile Lys Ala Leu  Pro Thr Asp Trp Leu  Ile Tyr Asp 
    1025                 1030                 1035             


Glu Met  Thr Arg Ala His Arg  Ile Ala Asn Ile Arg  Cys Cys Ser 
    1040                 1045                 1050             


Ala Val  Thr Pro Val Thr Ile  Leu Val Phe Cys Gly  Pro Ala Arg 
    1055                 1060                 1065             


Leu Ala  Ser Asn Ala Leu Gln  Glu Pro Ser Ser Phe  Arg Val Asp 
    1070                 1075                 1080             


Gly Ile  Pro Asn Asp Ser Ser  Asp Ser Glu Met Glu  Asp Lys Thr 
    1085                 1090                 1095             


Thr Ala  Asn Leu Ala Ala Leu  Lys Leu Asp Glu Trp  Leu His Phe 
    1100                 1105                 1110             


Thr Leu  Glu Pro Glu Ala Ala  Ser Leu Leu Leu Gln  Leu Arg Gln 
    1115                 1120                 1125             


Lys Trp  His Ser Leu Phe Leu  Arg Arg Met Arg Ala  Pro Ser Lys 
    1130                 1135                 1140             


Pro Trp  Ser Gln Val Asp Glu  Ala Thr Ile Arg Ala  Ile Ile Ala 
    1145                 1150                 1155             


Val Leu  Ser Thr Glu Glu Gln  Ser Ala Gly Leu Gln  Gln Pro Ser 
    1160                 1165                 1170             


Gly Ile  Gly Gln Arg Pro Arg  Pro Met Ser Ser Glu  Glu Leu Pro 
    1175                 1180                 1185             


Leu Ala  Ser Ser Trp Arg Ser  Asn Asn Ser Arg Lys  Ser Ser Ala 
    1190                 1195                 1200             


Asp Thr  Glu Phe Ser Asp Glu  Cys Thr Thr Ala Glu  Arg Val Leu 
    1205                 1210                 1215             


Met Lys  Ser Pro Ser Pro Ala  Leu His Pro Pro Gln  Lys Tyr Lys 
    1220                 1225                 1230             


Asp Arg  Gly Ile Leu His Pro  Lys Arg Gly Thr Glu  Asp Arg Ser 
    1235                 1240                 1245             


Asp Gln  Ser Ser Leu Lys Ser  Thr Asp Ser Ser Ser  Tyr Pro Ser 
    1250                 1255                 1260             


Pro Cys  Ala Ser Pro Ser Pro  Pro Ser Ser Gly Lys  Gly Ser Lys 
    1265                 1270                 1275             


Ser Pro  Ser Pro Arg Pro Asn  Met Pro Val Arg Tyr  Phe Ile Met 
    1280                 1285                 1290             


Lys Ser  Ser Asn Leu Arg Asn  Leu Glu Ile Ser Gln  Gln Lys Gly 
    1295                 1300                 1305             


Ile Trp  Ser Thr Thr Pro Ser  Asn Glu Arg Lys Leu  Asn Arg Ala 
    1310                 1315                 1320             


Phe Trp  Glu Ser Ser Ile Val  Tyr Leu Val Phe Ser  Val Gln Gly 
    1325                 1330                 1335             


Ser Gly  His Phe Gln Gly Phe  Ser Arg Met Ser Ser  Glu Ile Gly 
    1340                 1345                 1350             


Arg Glu  Lys Ser Gln Asp Trp  Gly Ser Ala Gly Leu  Gly Gly Val 
    1355                 1360                 1365             


Phe Lys  Val Glu Trp Ile Arg  Lys Glu Ser Leu Pro  Phe Gln Phe 
    1370                 1375                 1380             


Ala His  His Leu Leu Asn Pro  Trp Asn Asp Asn Lys  Lys Val Gln 
    1385                 1390                 1395             


Ile Ser  Arg Asp Gly Gln Glu  Leu Glu Pro Leu Val  Gly Glu Gln 
    1400                 1405                 1410             


Leu Leu  Gln Leu Trp Glu Arg  Leu Pro Leu Gly Glu  Lys Asn Thr 
    1415                 1420                 1425             


Thr Asp  
    1430 


<210>  1573
<211>  602
<212>  PRT
<213>  homo sapiens

<400>  1573

Met Ala Arg Leu Thr Lys Arg Arg Gln Ala Asp Thr Lys Ala Ile Gln 
1               5                   10                  15      


His Leu Trp Ala Ala Ile Glu Ile Ile Arg Asn Gln Lys Gln Ile Ala 
            20                  25                  30          


Asn Ile Asp Arg Ile Thr Lys Tyr Met Ser Arg Val His Gly Met His 
        35                  40                  45              


Pro Lys Glu Thr Thr Arg Gln Leu Ser Leu Ala Val Lys Asp Gly Leu 
    50                  55                  60                  


Ile Val Glu Thr Leu Thr Val Gly Cys Lys Gly Ser Lys Ala Gly Ile 
65                  70                  75                  80  


Glu Gln Glu Gly Tyr Trp Leu Pro Gly Asp Glu Ile Asp Trp Glu Thr 
                85                  90                  95      


Glu Asn His Asp Trp Tyr Cys Phe Glu Cys His Leu Pro Gly Glu Val 
            100                 105                 110         


Leu Ile Cys Asp Leu Cys Phe Arg Val Tyr His Ser Lys Cys Leu Ser 
        115                 120                 125             


Asp Glu Phe Arg Leu Arg Asp Ser Ser Ser Pro Trp Gln Cys Pro Val 
    130                 135                 140                 


Cys Arg Ser Ile Lys Lys Lys Asn Thr Asn Lys Gln Glu Met Gly Thr 
145                 150                 155                 160 


Tyr Leu Arg Phe Ile Val Ser Arg Met Lys Glu Arg Ala Ile Asp Leu 
                165                 170                 175     


Asn Lys Lys Gly Lys Asp Asn Lys His Pro Met Tyr Arg Arg Leu Val 
            180                 185                 190         


His Ser Ala Val Asp Val Pro Thr Ile Gln Glu Lys Val Asn Glu Gly 
        195                 200                 205             


Lys Tyr Arg Ser Tyr Glu Glu Phe Lys Ala Asp Ala Gln Leu Leu Leu 
    210                 215                 220                 


His Asn Thr Val Ile Phe Tyr Gly Ala Asp Ser Glu Gln Ala Asp Ile 
225                 230                 235                 240 


Ala Arg Met Leu Tyr Lys Asp Thr Cys His Glu Leu Asp Glu Leu Gln 
                245                 250                 255     


Leu Cys Lys Asn Cys Phe Tyr Leu Ser Asn Ala Arg Pro Asp Asn Trp 
            260                 265                 270         


Phe Cys Tyr Pro Cys Ile Pro Asn His Glu Leu Val Trp Ala Lys Met 
        275                 280                 285             


Lys Gly Phe Gly Phe Trp Pro Ala Lys Val Met Gln Lys Glu Asp Asn 
    290                 295                 300                 


Gln Val Asp Val Arg Phe Phe Gly His His His Gln Arg Ala Trp Ile 
305                 310                 315                 320 


Pro Ser Glu Asn Ile Gln Asp Ile Thr Val Asn Ile His Arg Leu His 
                325                 330                 335     


Val Lys Arg Ser Met Gly Trp Lys Lys Ala Cys Asp Glu Leu Glu Leu 
            340                 345                 350         


His Gln Arg Phe Leu Arg Glu Gly Arg Phe Trp Lys Ser Lys Asn Glu 
        355                 360                 365             


Asp Arg Gly Glu Glu Glu Ala Glu Ser Ser Ile Ser Ser Thr Ser Asn 
    370                 375                 380                 


Glu Gln Leu Lys Val Thr Gln Glu Pro Arg Ala Lys Lys Gly Arg Arg 
385                 390                 395                 400 


Asn Gln Ser Val Glu Pro Lys Lys Glu Glu Pro Glu Pro Glu Thr Glu 
                405                 410                 415     


Ala Val Ser Ser Ser Gln Glu Ile Pro Thr Met Pro Gln Pro Ile Glu 
            420                 425                 430         


Lys Val Ser Val Ser Thr Gln Thr Lys Lys Leu Ser Ala Ser Ser Pro 
        435                 440                 445             


Arg Met Leu His Arg Ser Thr Gln Thr Thr Asn Asp Gly Val Cys Gln 
    450                 455                 460                 


Ser Met Cys His Asp Lys Tyr Thr Lys Ile Phe Asn Asp Phe Lys Asp 
465                 470                 475                 480 


Arg Met Lys Ser Asp His Lys Arg Glu Thr Glu Arg Val Val Arg Glu 
                485                 490                 495     


Ala Leu Glu Lys Leu Arg Ser Glu Met Glu Glu Glu Lys Arg Gln Ala 
            500                 505                 510         


Val Asn Lys Ala Val Ala Asn Met Gln Gly Glu Met Asp Arg Lys Cys 
        515                 520                 525             


Lys Gln Val Lys Glu Lys Cys Lys Glu Glu Phe Val Glu Glu Ile Lys 
    530                 535                 540                 


Lys Leu Ala Thr Gln His Lys Gln Leu Ile Ser Gln Thr Lys Lys Lys 
545                 550                 555                 560 


Gln Trp Cys Tyr Asn Cys Glu Glu Glu Ala Met Tyr His Cys Cys Trp 
                565                 570                 575     


Asn Thr Ser Tyr Cys Ser Ile Lys Cys Gln Gln Glu His Trp His Ala 
            580                 585                 590         


Glu His Lys Arg Thr Cys Arg Arg Lys Arg 
        595                 600         


<210>  1574
<211>  953
<212>  PRT
<213>  homo sapiens

<400>  1574

Met Glu Glu Ser Ser Ser Val Ala Met Leu Val Pro Asp Ile Gly Glu 
1               5                   10                  15      


Gln Glu Ala Ile Leu Thr Ala Glu Ser Ile Ile Ser Pro Ser Leu Glu 
            20                  25                  30          


Ile Asp Glu Gln Arg Lys Thr Lys Pro Asp Pro Leu Ile His Val Ile 
        35                  40                  45              


Gln Lys Leu Ser Lys Ile Val Glu Asn Glu Lys Ser Gln Lys Cys Leu 
    50                  55                  60                  


Leu Ile Gly Lys Lys Arg Pro Arg Ser Ser Ala Ala Thr His Ser Leu 
65                  70                  75                  80  


Glu Thr Gln Glu Leu Cys Glu Ile Pro Ala Lys Val Ile Gln Ser Pro 
                85                  90                  95      


Ala Ala Asp Thr Arg Arg Ala Glu Met Ser Gln Thr Asn Phe Thr Pro 
            100                 105                 110         


Asp Thr Leu Ala Gln Asn Glu Gly Lys Ala Met Ser Tyr Gln Cys Ser 
        115                 120                 125             


Leu Cys Lys Phe Leu Ser Ser Ser Phe Ser Val Leu Lys Asp His Ile 
    130                 135                 140                 


Lys Gln His Gly Gln Gln Asn Glu Val Ile Leu Met Cys Ser Glu Cys 
145                 150                 155                 160 


His Ile Thr Ser Arg Ser Gln Glu Glu Leu Glu Ala His Val Val Asn 
                165                 170                 175     


Asp His Asp Asn Asp Ala Asn Ile His Thr Gln Ser Lys Ala Gln Gln 
            180                 185                 190         


Cys Val Ser Pro Ser Ser Ser Leu Cys Arg Lys Thr Thr Glu Arg Asn 
        195                 200                 205             


Glu Thr Ile Pro Asp Ile Pro Val Ser Val Asp Asn Leu Gln Thr His 
    210                 215                 220                 


Thr Val Gln Thr Ala Ser Val Ala Glu Met Gly Arg Arg Lys Trp Tyr 
225                 230                 235                 240 


Ala Tyr Glu Gln Tyr Gly Met Tyr Arg Cys Leu Phe Cys Ser Tyr Thr 
                245                 250                 255     


Cys Gly Gln Gln Arg Met Leu Lys Thr His Ala Trp Lys His Ala Gly 
            260                 265                 270         


Glu Val Asp Cys Ser Tyr Pro Ile Phe Glu Asn Glu Asn Glu Pro Leu 
        275                 280                 285             


Gly Leu Leu Asp Ser Ser Ala Ala Ala Ala Pro Gly Gly Val Asp Ala 
    290                 295                 300                 


Val Val Ile Ala Ile Gly Glu Ser Glu Leu Ser Ile His Asn Gly Pro 
305                 310                 315                 320 


Ser Val Gln Val Gln Ile Cys Ser Ser Glu Gln Leu Ser Ser Ser Ser 
                325                 330                 335     


Pro Leu Glu Gln Ser Ala Glu Arg Gly Val His Leu Ser Gln Ser Val 
            340                 345                 350         


Thr Leu Asp Pro Asn Glu Glu Glu Met Leu Glu Val Ile Ser Asp Ala 
        355                 360                 365             


Glu Glu Asn Leu Ile Pro Asp Ser Leu Leu Thr Ser Ala Gln Lys Ile 
    370                 375                 380                 


Ile Ser Ser Ser Pro Asn Lys Lys Gly His Val Asn Val Ile Val Glu 
385                 390                 395                 400 


Arg Leu Pro Ser Ala Glu Glu Thr Leu Ser Gln Lys Arg Phe Leu Met 
                405                 410                 415     


Asn Thr Glu Met Glu Glu Gly Lys Asp Leu Ser Leu Thr Glu Ala Gln 
            420                 425                 430         


Ile Gly Arg Glu Gly Met Asp Asp Val Tyr Arg Ala Asp Lys Cys Thr 
        435                 440                 445             


Val Asp Ile Gly Gly Leu Ile Ile Gly Trp Ser Ser Ser Glu Lys Lys 
    450                 455                 460                 


Asp Glu Leu Met Asn Lys Gly Leu Ala Thr Asp Glu Asn Ala Pro Pro 
465                 470                 475                 480 


Gly Arg Arg Arg Thr Asn Ser Glu Ser Leu Arg Leu His Ser Leu Ala 
                485                 490                 495     


Ala Glu Ala Leu Val Thr Met Pro Ile Arg Ala Ala Glu Leu Thr Arg 
            500                 505                 510         


Ala Asn Leu Gly His Tyr Gly Asp Ile Asn Leu Leu Asp Pro Asp Thr 
        515                 520                 525             


Ser Gln Arg Gln Val Asp Ser Thr Leu Ala Ala Tyr Ser Lys Met Met 
    530                 535                 540                 


Ser Pro Leu Lys Asn Ser Ser Asp Gly Leu Thr Ser Leu Asn Gln Ser 
545                 550                 555                 560 


Asn Ser Thr Leu Val Ala Leu Pro Glu Gly Arg Gln Glu Leu Ser Asp 
                565                 570                 575     


Gly Gln Val Lys Thr Gly Ile Ser Met Ser Leu Leu Thr Val Ile Glu 
            580                 585                 590         


Lys Leu Arg Glu Arg Thr Asp Gln Asn Ala Ser Asp Asp Asp Ile Leu 
        595                 600                 605             


Lys Glu Leu Gln Asp Asn Ala Gln Cys Gln Pro Asn Ser Asp Thr Ser 
    610                 615                 620                 


Leu Ser Gly Asn Asn Val Val Glu Tyr Ile Pro Asn Ala Glu Arg Pro 
625                 630                 635                 640 


Tyr Arg Cys Arg Leu Cys His Tyr Thr Ser Gly Asn Lys Gly Tyr Ile 
                645                 650                 655     


Lys Gln His Leu Arg Val His Arg Gln Arg Gln Pro Tyr Gln Cys Pro 
            660                 665                 670         


Ile Cys Glu His Ile Ala Asp Asn Ser Lys Asp Leu Glu Ser His Met 
        675                 680                 685             


Ile His His Cys Lys Thr Arg Ile Tyr Gln Cys Lys Gln Cys Glu Glu 
    690                 695                 700                 


Ser Phe His Tyr Lys Ser Gln Leu Arg Asn His Glu Arg Glu Gln His 
705                 710                 715                 720 


Ser Leu Pro Asp Thr Leu Ser Ile Ala Thr Ser Asn Glu Pro Arg Ile 
                725                 730                 735     


Ser Ser Asp Thr Ala Asp Gly Lys Cys Val Gln Glu Gly Asn Lys Ser 
            740                 745                 750         


Ser Val Gln Lys Gln Tyr Arg Cys Asp Val Cys Asp Tyr Thr Ser Thr 
        755                 760                 765             


Thr Tyr Val Gly Val Arg Asn His Arg Arg Ile His Asn Ser Asp Lys 
    770                 775                 780                 


Pro Tyr Arg Cys Ser Leu Cys Gly Tyr Val Cys Ser His Pro Pro Ser 
785                 790                 795                 800 


Leu Lys Ser His Met Trp Lys His Ala Ser Asp Gln Asn Tyr Asn Tyr 
                805                 810                 815     


Glu Gln Val Asn Lys Ala Ile Asn Asp Ala Ile Ser Gln Ser Gly Arg 
            820                 825                 830         


Val Leu Gly Lys Ser Pro Gly Lys Thr Gln Leu Lys Ser Ser Glu Glu 
        835                 840                 845             


Ser Ala Asp Pro Val Thr Gly Ser Ser Glu Asn Ala Val Ser Ser Ser 
    850                 855                 860                 


Glu Leu Met Ser Gln Thr Pro Ser Glu Val Leu Gly Thr Asn Glu Asn 
865                 870                 875                 880 


Glu Lys Leu Ser Pro Thr Ser Asn Thr Ser Tyr Ser Leu Glu Lys Ile 
                885                 890                 895     


Ser Ser Leu Ala Pro Pro Ser Met Glu Tyr Cys Val Leu Leu Phe Cys 
            900                 905                 910         


Cys Cys Ile Cys Gly Phe Glu Ser Thr Ser Lys Glu Asn Leu Leu Asp 
        915                 920                 925             


His Met Lys Glu His Glu Gly Glu Ile Val Asn Ile Ile Leu Asn Lys 
    930                 935                 940                 


Asp His Asn Thr Ala Leu Asn Thr Asn 
945                 950             


<210>  1575
<211>  354
<212>  PRT
<213>  homo sapiens

<400>  1575

Met Ser Ala Phe Asp Met Ser His Asp Phe Phe Phe Cys Leu Thr Ser 
1               5                   10                  15      


Glu Trp Glu Ile Gln Pro Arg Thr Lys Arg Ser Ser Leu Gln Gln Gly 
            20                  25                  30          


Phe Leu Lys Asn Gln Ile Phe Thr Gly Ile Gln Met Gln Thr Arg Ser 
        35                  40                  45              


Tyr Ser Gly Trp Lys Leu Cys Glu Asn Cys Gly Glu Val Phe Ser Glu 
    50                  55                  60                  


Gln Phe Cys Leu Lys Thr His Met Arg Ala Gln Asn Gly Gly Asn Thr 
65                  70                  75                  80  


Phe Glu Gly Asn Cys Tyr Gly Lys Asp Ser Ile Ser Val His Lys Glu 
                85                  90                  95      


Ala Ser Ile Gly Gln Glu Leu Ser Lys Phe Asn Pro Cys Gly Lys Val 
            100                 105                 110         


Phe Thr Leu Thr Pro Gly Leu Ala Val His Leu Glu Ile Leu Asn Gly 
        115                 120                 125             


Arg Gln Pro Tyr Lys Cys Lys Glu Cys Gly Lys Gly Phe Lys Tyr Phe 
    130                 135                 140                 


Ala Ser Leu Asp Asn His Met Gly Ile His Ile Gly Glu Lys Leu Cys 
145                 150                 155                 160 


Glu Phe Gln Glu Cys Glu Arg Ala Ile Thr Thr Ser Ser His Leu Lys 
                165                 170                 175     


Gln Cys Val Ala Val His Thr Gly Lys Lys Ser Glu Lys Thr Lys Asn 
            180                 185                 190         


Cys Gly Lys Ser Phe Thr Asn Phe Ser Gln Leu Ser Ala His Ala Lys 
        195                 200                 205             


Thr His Lys Gly Glu Lys Ser Phe Glu Cys Lys Glu Cys Gly Arg Ser 
    210                 215                 220                 


Phe Arg Asn Ser Ser Ser Phe Asn Val His Ile Gln Ile His Thr Gly 
225                 230                 235                 240 


Ile Lys Pro His Lys Cys Thr Glu Cys Gly Lys Ala Phe Thr Arg Ser 
                245                 250                 255     


Thr His Leu Thr Gln His Val Arg Thr His Thr Gly Ile Lys Pro Tyr 
            260                 265                 270         


Glu Cys Lys Glu Cys Gly Gln Ala Phe Thr Gln Tyr Thr Gly Leu Ala 
        275                 280                 285             


Ile His Ile Arg Asn His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu 
    290                 295                 300                 


Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Thr Gln His Arg Arg 
305                 310                 315                 320 


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Val Glu Cys Gly Lys Thr 
                325                 330                 335     


Phe Ile Thr Ser Ser His Arg Ser Lys His Leu Lys Thr His Ser Gly 
            340                 345                 350         


Glu Arg 
        


<210>  1576
<211>  1542
<212>  DNA
<213>  Escherichia coli

<400>  1576
aaattgaaga gtttgatcat ggctcagatt gaacgctggc ggcaggccta acacatgcaa       60

gtcgaacggt aacaggaaga agcttgcttc tttgctgacg agtggcggac gggtgagtaa      120

tgtctgggaa actgcctgat ggagagggat aactactgga aacggtagct aataccgcat      180

aacgtcgcaa gaccaaagag ggggaccttc gggcctcttg ccatcggatg tgcccagatg      240

ggattagcta gtaggtgggg taacggctca cctaggcgac gatccctagc tggtctgaga      300

ggatgaccag ccacactgga actgagacac ggtccagact cctacgggag gcagcagtgg      360

ggaatattgc acaatgggcg caagcctgat gcagccatgc cgcgtgtatg aagaaggcct      420

tcgggttgta aagtactttc agcggggagg aagggagtaa agttaatacc tttgctcatt      480

gacgttaccc gcagaagaag caccggctaa ctccgtgcca gcagccgcgg taatacggag      540

ggtgcaagcg ttaatcggaa ttactgggcg taaagcgcac gcaggcggtt tgttaagtca      600

gatgtgaaat ccccgggctc aacctgggaa ctgcatctga tactggcaag cttgagtctc      660

gtagaggggg gtagaattcc aggtgtagcg gtgaaatgcg tagagatctg gaggaatacc      720

ggtggcgaag gcggccccct ggacgaagac tgacgctcag gtgcgaaagc gtggggagca      780

aacaggatta gataccctgg tagtccacgc cgtaaacgat gtcgacttgg aggttgtgcc      840

cttgaggcgt ggcttccgga gctaacgcgt taagtcgacc gcctggggag tacggccgca      900

aggttaaaac tcaaatgaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat      960

tcgatgcaac gcgaagaacc ttacctggtc ttgacatcca cagaactttc cagagatgga     1020

ttggtgcctt cgggaactgt gagacaggtg ctgcatggct gtcgtcagct cgtgttgtga     1080

aatgttgggt taagtcccgc aacgagcgca acccttatcc tttgttgcca gcggtccggc     1140

cgggaactca aaggagactg ccagtgataa actggaggaa ggtggggatg acgtcaagtc     1200

atcatggccc ttacgaccag ggctacacac gtgctacaat ggcgcataca aagagaagcg     1260

acctcgcgag agcaagcgga cctcataaag tgcgtcgtag tccggattgg agtctgcaac     1320

tcgactccat gaagtcggaa tcgctagtaa tcgtggatca gaatgccacg gtgaatacgt     1380

tcccgggcct tgtacacacc gcccgtcaca ccatgggagt gggttgcaaa agaagtaggt     1440

agcttaacct tcgggagggc gcttaccact ttgtgattca tgactggggt gaagtcgtaa     1500

caaggtaacc gtaggggaac ctgcggttgg atcacctcct ta                        1542


