                         SEQUENCE LISTING

<110>  SOLSTICE BIOLOGICS, LTD.
 
<120>  POLYNUCLEOTIDE CONSTRUCTS

<130>  50925-023WO2

<140>  PCT/US2017/047447
<141>  2017-08-17

<150>  US 62/376,182
<151>  2016-08-17

<160>  250   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  1
gguuaacacc auuuacuuca a                                                 21


<210>  2
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  2
uugaaguaaa ugguguuaac cag                                               23


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  3
gguuaacacc auuuacuuca a                                                 21


<210>  4
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  4
uugaaguaaa ugguguuaac cag                                               23


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  5
aacaguguuc uugcucuaua a                                                 21


<210>  6
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  6
uuauagagca agaacacugu uuu                                               23


<210>  7
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  7
uuauagagca agaacacugu uuu                                               23


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  8
aacaguguuc uugcucuaua a                                                 21


<210>  9
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X1 in figure 8B

<400>  9
aacaguguuc uugcucuaua an                                                22


<210>  10
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-n-butyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X1 in Figure 8B

<400>  10
aacaguguuc uugcucuaua ann                                               23


<210>  11
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X1 in Figure 8B

<400>  11
aacaguguuc uugcucuaua ann                                               23


<210>  12
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X1 in Figure 8B

<400>  12
aacaguguuc uugcucuaua an                                                22


<210>  13
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  13
aacaguguuc uugcucuaua ann                                               23


<210>  14
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X1 in Figure 8B

<400>  14
gguuaacacc auuuacuuca an                                                22


<210>  15
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-n-butyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X1 in Figure 8B

<400>  15
gguuaacacc auuuacuuca ann                                               23


<210>  16
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X1 in Figure 8B

<400>  16
gguuaacacc auuuacuuca ann                                               23


<210>  17
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X1 in Figure 8B

<400>  17
gguuaacacc auuuacuuca an                                                22


<210>  18
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  18
gguuaacacc auuuacuuca ann                                               23


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(24)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<400>  19
aacaguguuc uugcucuaua attt                                              24


<210>  20
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  20
uuuucuagac cuguuuugcu unn                                               23


<210>  21
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  21
aagcaaaaca ggucuagaaa agu                                               23


<210>  22
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  22
caagcagaca uuuaucuuuu unn                                               23


<210>  23
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  23
aaaaagauaa augucugcuu gcu                                               23


<210>  24
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  24
cuagaccugu uuugcuuuug unn                                               23


<210>  25
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  25
acaaaagcaa aacaggucua gaa                                               23


<210>  26
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  26
cuagaccugu uuugcuuuug unn                                               23


<210>  27
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  27
acaaaagcaa aacaggucua gaa                                               23


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(24)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<400>  28
gguuaacacc auuuacuuca attt                                              24


<210>  29
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  n is X3 in Figure 8B

<400>  29
gguuaacacc auuuacuuca annn                                              24


<210>  30
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  30
gguuaacacc auuuacuuca ann                                               23


<210>  31
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<400>  31
gguuaacacc auuuacuuca an                                                22


<210>  32
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X4 in Figure 8B

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is 3 C3-OH group

<400>  32
gguuaacacc auuuacuuca annn                                              24


<210>  33
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X4 in Figure 8B

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is 3 C3-OH group

<400>  33
gguuaacacc auuuacuuca annn                                              24


<210>  34
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X4 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  34
gguuaacacc auuuacuuca ann                                               23


<210>  35
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-phenethyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  35
uugaaguaaa ugguguuaac cag                                               23


<210>  36
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-n-butyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  36
uugaaguaaa ugguguuaac cag                                               23


<210>  37
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  37
uuauagagca agaacacugu uuu                                               23


<210>  38
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-phenethyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  38
uuauagagca agaacacugu uuu                                               23


<210>  39
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-uridine having a 3-carbon bonded to 
       2-(t-butyl-dithio)phenyl-ethyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  39
uuauagagca agaacacugu uuu                                               23


<210>  40
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-n-butyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  40
uuauagagca agaacacugu uuu                                               23


<210>  41
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-2-aminoethyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X5 in Figure 8B

<400>  41
gguuaacacc auuuacuuca ann                                               23


<210>  42
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-2-aminoethyl-diethylene glycol 
       phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X5 in Figure 8B

<400>  42
gguuaacacc auuuacuuca ann                                               23


<210>  43
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-2-aminopropyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X5 in Figure 8B

<400>  43
gguuaacacc auuuacuuca ann                                               23


<210>  44
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  44
gguuaacacc auuuacuuca ann                                               23


<210>  45
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  45
uugaaguaaa ugguguuaac cag                                               23


<210>  46
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  46
gguuaacacc auuuacuuca ann                                               23


<210>  47
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  47
uugaaguaaa ugguguuaac cag                                               23


<210>  48
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  48
gguuaacacc auuuacuuca ann                                               23


<210>  49
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  49
uugaaguaaa ugguguuaac cag                                               23


<210>  50
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  50
gguuaacacc auuuacuuca ann                                               23


<210>  51
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  51
uugaaguaaa ugguguuaac cag                                               23


<210>  52
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  52
gguuaacacc auuuacuuca ann                                               23


<210>  53
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  53
uugaaguaaa ugguguuaac cag                                               23


<210>  54
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  54
uugaaguaaa ugguguuaac cag                                               23


<210>  55
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  55
uugaaguaaa ugguguuaac cag                                               23


<210>  56
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  56
uugaaguaaa ugguguuaac cag                                               23


<210>  57
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  57
uugaaguaaa ugguguuaac cag                                               23


<210>  58
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  58
gguuaacacc auuuacuuca cnn                                               23


<210>  59
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  59
gguuaacacc auuuacuuca gnn                                               23


<210>  60
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  60
gguuaacacc auuuacuuca unn                                               23


<210>  61
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is 5'-terminal 2-(t-butyl-dithio)phenylethyl phosphodiester 
       (PO)

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  61
nuugaaguaa augguguuaa ccag                                              24


<210>  62
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is 5'-terminal 2-(t-butyl-dithio)phenylethyl phosphodiester 
       (PS)

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  62
nuugaaguaa augguguuaa ccag                                              24


<210>  63
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is 5'-terminal phosphate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  63
nuugaaguaa augguguuaa ccag                                              24


<210>  64
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is 5'-terminal phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  64
nuugaaguaa augguguuaa ccag                                              24


<210>  65
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  65
uugaaguaaa ugguguuaac cag                                               23


<210>  66
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  66
uuganaguaa augguguuaa ccag                                              24


<210>  67
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  67
uugaanguaa augguguuaa ccag                                              24


<210>  68
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  68
uugaagnuaa augguguuaa ccag                                              24


<210>  69
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is 3 C3-OH group

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2-methoxy-2-deoxyribose

<400>  69
uugaagnuaa augguguuaa ccag                                              24


<210>  70
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  3'-RP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3'-SP chiral phosphorothioate

<400>  70
gguuaacacc auuuacuuca ann                                               23


<210>  71
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  3'-SP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3'-SP chiral phosphorothioate

<400>  71
gguuaacacc auuuacuuca ann                                               23


<210>  72
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  3'-SP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3'-RP chiral phosphorothioate

<400>  72
gguuaacacc auuuacuuca ann                                               23


<210>  73
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3'-RP chiral phosphorothioate

<400>  73
gguuaacacc auuuacuuca ann                                               23


<210>  74
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3'-SP chiral phosphorothioate

<400>  74
gguuaacacc auuuacuuca ann                                               23


<210>  75
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  3'-RP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<400>  75
gguuaacacc auuuacuuca ann                                               23


<210>  76
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  3'-SP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is X3 in Figure 8B

<400>  76
gguuaacacc auuuacuuca ann                                               23


<210>  77
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  77
uugaaguaaa ugguguuaac cag                                               23


<210>  78
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  78
uugaaguaaa ugguguuaac cag                                               23


<210>  79
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  79
uugaaguaaa ugguguuaac cag                                               23


<210>  80
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  80
uugaaguaaa ugguguuaac cag                                               23


<210>  81
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  81
gguuaacacc auuuacuuca ann                                               23


<210>  82
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  82
gguuaacacc auuuacuuca ann                                               23


<210>  83
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  83
uugaaguaaa ugguguuaac cag                                               23


<210>  84
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2-NH2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  84
gguuaacacc auuuacuuca ann                                               23


<210>  85
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2-NH2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  85
gguuaacacc auuuacuuca ann                                               23


<210>  86
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  86
uugaaguaaa ugguguuaac cuc                                               23


<210>  87
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  87
cguuaacacc auuuacuuca ann                                               23


<210>  88
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  88
uugaaguaaa ugguguuaac guc                                               23


<210>  89
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  89
ccuuaacacc auuuacuuca ann                                               23


<210>  90
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  90
uugaaguaaa ugguguuaag guc                                               23


<210>  91
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  91
ccauaacacc auuuacuuca ann                                               23


<210>  92
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  92
uugaaguaaa ugguguuaug guc                                               23


<210>  93
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  93
ccaaaacacc auuuacuuca ann                                               23


<210>  94
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  94
uugaaguaaa ugguguuuug guc                                               23


<210>  95
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  95
gguuaacacc auuuacuuca ann                                               23


<210>  96
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  96
gguuaacacc auuuacuuca ann                                               23


<210>  97
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  97
gguuaacacc auuuacuuca ann                                               23


<210>  98
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  98
uugaaguaaa ugguguuaac cag                                               23


<210>  99
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  99
uugaaguaaa ugguguuaac cag                                               23


<210>  100
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  100
uugaaguaaa ugguguuaac cag                                               23


<210>  101
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  101
gguuaacacc auuuacuuca ann                                               23


<210>  102
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  102
gguuaacacc auuuacuuca ann                                               23


<210>  103
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  103
gguuaacacc auuuacuuca ann                                               23


<210>  104
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  104
gguuaacacc auuuacuuca ann                                               23


<210>  105
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  105
gguuaacacc auuuacuuca ann                                               23


<210>  106
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  106
uugaaguaaa ugguguuaac cag                                               23


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  107
gguucugguu aacaccauun n                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  108
aaugguguua accagaacca g                                                 21


<210>  109
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  109
cugguucugg uuaacaccau unn                                               23


<210>  110
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  110
aaugguguua accagaacca ggg                                               23


<210>  111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  111
uucugguuaa caccauuuan n                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  112
uaaauggugu uaaccagaac c                                                 21


<210>  113
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  113
gguucugguu aacaccauuu ann                                               23


<210>  114
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  114
uaaauggugu uaaccagaac cag                                               23


<210>  115
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  115
ucugguuaac accauuuaan n                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  116
uuaaauggug uuaaccagaa c                                                 21


<210>  117
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  117
guucugguua acaccauuua ann                                               23


<210>  118
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  118
uuaaauggug uuaaccagaa cca                                               23


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  119
ugguuaacac cauuuacuun n                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  120
aaguaaaugg uguuaaccag a                                                 21


<210>  121
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  121
ucugguuaac accauuuacu unn                                               23


<210>  122
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  122
aaguaaaugg uguuaaccag aac                                               23


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  123
gguuaacacc auuuacuuan n                                                 21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  124
uaaguaaaug guguuaacca g                                                 21


<210>  125
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  125
cugguuaaca ccauuuacuu ann                                               23


<210>  126
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  126
uaaguaaaug guguuaacca gaa                                               23


<210>  127
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  127
uuaacaccau uuacuucaan n                                                 21


<210>  128
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  128
uugaaguaaa ugguguuaac c                                                 21


<210>  129
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  129
uaacaccauu uacuucaaan n                                                 21


<210>  130
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  130
uuugaaguaa augguguuaa c                                                 21


<210>  131
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  131
guuaacacca uuuacuucaa ann                                               23


<210>  132
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  132
uuugaaguaa augguguuaa cca                                               23


<210>  133
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  133
acaccauuua cuucaaggan n                                                 21


<210>  134
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  134
uccuugaagu aaaugguguu a                                                 21


<210>  135
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  135
uaacaccauu uacuucaagg ann                                               23


<210>  136
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  136
uccuugaagu aaaugguguu aac                                               23


<210>  137
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  137
ccauuuacuu caagggccun n                                                 21


<210>  138
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  138
aggcccuuga aguaaauggu g                                                 21


<210>  139
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  139
cauuuacuuc aagggccuan n                                                 21


<210>  140
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  140
uaggcccuug aaguaaaugg u                                                 21


<210>  141
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  141
auuuacuuca agggccugun n                                                 21


<210>  142
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  142
acaggcccuu gaaguaaaug g                                                 21


<210>  143
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  143
uuaaauggug uuaaccagaa c                                                 21


<210>  144
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  144
uuaaauggug uuaaccagaa c                                                 21


<210>  145
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  145
aaguaaaugg uguuaaccag a                                                 21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  146
aaguaaaugg uguuaaccag a                                                 21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  147
ugguuaacac cauuuacuun n                                                 21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  148
ugguuaacac cauuuacuun n                                                 21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is 3 C3-OH group

<400>  149
ugguuaacac cauuuacuun n                                                 21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  150
aaguaaaugg uguuaaccag a                                                 21


<210>  151
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  151
ucugguuaac accauuuacu unn                                               23


<210>  152
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  152
aaguaaaugg uguuaaccag aac                                               23


<210>  153
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  153
uugaaguaaa ugguguuaac cag                                               23


<210>  154
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  154
uugaaguaaa ugguguuaac cag                                               23


<210>  155
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  155
uugaaguaaa ugguguuaac cag                                               23


<210>  156
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  156
uugaaguaaa ugguguuaac cag                                               23


<210>  157
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  157
uugaaguaaa ugguguuaac cag                                               23


<210>  158
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  158
uugaaguaaa ugguguuaac cag                                               23


<210>  159
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  159
uugaaguaaa ugguguuaac cag                                               23


<210>  160
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  160
uugaaguaaa ugguguuaac cag                                               23


<210>  161
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  161
uugaaguaaa ugguguuaac cag                                               23


<210>  162
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  162
uugaaguaaa ugguguuaac cag                                               23


<210>  163
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  163
uugaaguaaa ugguguuaac cag                                               23


<210>  164
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  164
uugaaguaaa ugguguuaac cag                                               23


<210>  165
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  165
uugaaguaaa ugguguuaac cag                                               23


<210>  166
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  166
uugaaguaaa ugguguuaac cag                                               23


<210>  167
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  167
uugaaguaaa ugguguuaac cag                                               23


<210>  168
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  168
uugaaguaaa ugguguuaac cag                                               23


<210>  169
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  169
uugaaguaaa ugguguuaac cag                                               23


<210>  170
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  170
uugaaguaaa ugguguuaac cag                                               23


<210>  171
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  171
uugaaguaaa ugguguuaac cag                                               23


<210>  172
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  172
uugaaguaaa ugguguuaac cag                                               23


<210>  173
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  173
uugaaguaaa ugguguuaac cag                                               23


<210>  174
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  174
uugaaguaaa ugguguuaac cag                                               23


<210>  175
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  175
uugaaguaaa ugguguuaac cag                                               23


<210>  176
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  176
uugaaguaaa ugguguuaac cag                                               23


<210>  177
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  177
gguuaacacc auuuacuuca ann                                               23


<210>  178
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  178
gguuaacacc auuuacuuca ann                                               23


<210>  179
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  179
gguuaacacc auuuacuuca ann                                               23


<210>  180
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  180
gguuaacacc auuuacuuca ann                                               23


<210>  181
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  181
uugaaguaaa ugguguuaac cag                                               23


<210>  182
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  182
uugaaguaaa ugguguuaac cag                                               23


<210>  183
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  183
uugaaguaaa ugguguuaac cag                                               23


<210>  184
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  184
uugaaguaaa ugguguuaac cac                                               23


<210>  185
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  185
uuuugcuuuu guaacuugaa ann                                               23


<210>  186
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  186
uuucaaguua caaaagcaaa aca                                               23


<210>  187
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  187
uuuugcuuuu guaacuugaa ann                                               23


<210>  188
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  188
uuucaaguua caaaagcaaa aca                                               23


<210>  189
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  189
guuuuguagc auuuuuauua ann                                               23


<210>  190
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  190
uuaauaaaaa ugcuacaaaa ccc                                               23


<210>  191
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  191
guuuuguagc auuuuuauua ann                                               23


<210>  192
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  192
guuuuguagc auuuuuauua ann                                               23


<210>  193
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  193
uuaauaaaaa ugcuacaaaa ccc                                               23


<210>  194
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-methoxy-2-deoxyribose-3'-RP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2-methoxy-2-deoxyribose-3'-SP chiral phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  194
uuaauaaaaa ugcuacaaaa ccc                                               23


<210>  195
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  195
uuganguaaa ugguguuaac cag                                               23


<210>  196
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  196
uugaanuaaa ugguguuaac cag                                               23


<210>  197
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  197
uugaagnaaa ugguguuaac cag                                               23


<210>  198
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  198
aacaguguuc uugcucuaua a                                                 21


<210>  199
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  199
uuaungagca agaacacugu uuu                                               23


<210>  200
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  200
uuauagngca agaacacugu uuu                                               23


<210>  201
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  201
uugcuuuugu aacuugaaga u                                                 21


<210>  202
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  202
aucuncaagu uacaaaagca aaa                                               23


<210>  203
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  203
aucuucnagu uacaaaagca aaa                                               23


<210>  204
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  204
gcuuuuguaa cuugaagaua u                                                 21


<210>  205
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  205
auaunuucaa guuacaaaag caa                                               23


<210>  206
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  206
auaucuncaa guuacaaaag caa                                               23


<210>  207
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  207
uaacuugaag auauuuauuc u                                                 21


<210>  208
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  208
agaanaaaua ucuucaaguu aca                                               23


<210>  209
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  209
agaauanaua ucuucaaguu aca                                               23


<210>  210
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  210
guuuuguagc auuuuuauua a                                                 21


<210>  211
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  211
uuaanaaaaa ugcuacaaaa ccc                                               23


<210>  212
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  212
uuaauanaaa ugcuacaaaa ccc                                               23


<210>  213
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2-fluoro-2-deoxyribose

<400>  213
uuguagcauu uuuauuaaua u                                                 21


<210>  214
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  214
auaunaauaa aaaugcuaca aaa                                               23


<210>  215
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  215
auauuanuaa aaaugcuaca aaa                                               23


<210>  216
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  216
uuganguaaa ugguguuaac cag                                               23


<210>  217
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  217
uuganguaaa ugguguuaac cag                                               23


<210>  218
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  218
uuganguaaa ugguguuaac cag                                               23


<210>  219
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  219
uuganguaaa ugguguuaac cag                                               23


<210>  220
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  3'-phosphorothioate

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  220
uugaagnaaa ugguguuaac cag                                               23


<210>  221
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  221
uugaagnaaa ugguguuaac cag                                               23


<210>  222
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  3'-phosphorothioate

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  222
uugaagnaaa ugguguuaac cag                                               23


<210>  223
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  223
uuganguaaa ugguguuaac cag                                               23


<210>  224
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X4 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  224
uuganguaaa ugguguuaac cag                                               23


<210>  225
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is X4 in Figure 8B

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  225
uuganguaaa ugguguuaac cag                                               23


<210>  226
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X3 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  226
uugaagnaaa ugguguuaac cag                                               23


<210>  227
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X4 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  227
uugaagnaaa ugguguuaac cag                                               23


<210>  228
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-homopropargyl phosphotriester

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is X4 in Figure 8B

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  228
uugaagnaaa ugguguuaac cag                                               23


<210>  229
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  229
uugnaguaaa ugguguuaac cag                                               23


<210>  230
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  230
uuganguaaa ugguguuaac cag                                               23


<210>  231
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  231
uugaanuaaa ugguguuaac cag                                               23


<210>  232
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  232
uugnaguaaa ugguguuaac cag                                               23


<210>  233
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  233
uuganguaaa ugguguuaac cag                                               23


<210>  234
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  234
uugaanuaaa ugguguuaac cag                                               23


<210>  235
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  235
uugnaguaaa ugguguuaac cag                                               23


<210>  236
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (5)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  236
uugnaguaaa ugguguuaac cag                                               23


<210>  237
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (5)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  237
uugnaguaaa ugguguuaac cag                                               23


<210>  238
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is X2 in Figure 8B

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is 3 C3-OH group

<400>  238
gguuaacacc auuuacuuca ann                                               23


<210>  239
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  239
uuganguaaa ugguguuaac cag                                               23


<210>  240
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  240
uuganguaaa ugguguuaac cag                                               23


<210>  241
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  241
uuganguaaa ugguguuaac cag                                               23


<210>  242
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  242
uugaanuaaa ugguguuaac cag                                               23


<210>  243
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  243
uugaanuaaa ugguguuaac cag                                               23


<210>  244
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is inosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  244
uugaanuaaa ugguguuaac cag                                               23


<210>  245
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  245

Arg Gly Asp 
1           


<210>  246
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  246

Tyr Ile Gly Ser Arg 
1               5   


<210>  247
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tic(psi)(CH2NH)

<400>  247

Thr Xaa Pro Pro 
1               


<210>  248
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(21)
<223>  2-methoxy-2-deoxyribose

<400>  248
gguuaacacc auuuacuuca a                                                 21


<210>  249
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2-fluoro-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2-methoxy-2-deoxyribose

<400>  249
uugaaguaaa ugguguuaac cag                                               23


<210>  250
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2-methoxy-2-deoxyribose-3'-phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2-fluoro-2-deoxyribose

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2-methoxy-2-deoxyribose

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is X3 in Figure 8B

<400>  250
gguuaacacc auuuacuuca ann                                               23


