
                                SEQUENCE LISTING

<110> The Scripps Research Institute
      Xianglei Yang
      Yi Shi
      Ze Liu  

<120> Control Angiogenesis by Regulating
  Phosphorylation of Seryl-tRNA Synthetase (SerRS)
  

<130> AARS.004WO

<150> 62/375592
<151> 2017-08-16

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 514
<212> PRT
<213> Homo Sapiens

<400> 1
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Ser Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 2
<211> 514
<212> PRT
<213> Homo sapiens

<400> 2
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Ala Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 3
<211> 514
<212> PRT
<213> Homo sapiens

<400> 3
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Ser Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ala Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 4
<211> 514
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Ala Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ala Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 5
<211> 514
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Asp Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Asp Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 6
<211> 514
<212> PRT
<213> Homo sapiens

<400> 6
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Asn Leu Lys Val Glu Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Glu Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys
        435                 440                 445             
Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala
                485                 490                 495     
Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr
            500                 505                 510         
Asp Ala
        


<210> 7
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 7
gaaagtcgca caaatcaaaa aagtccgact cctcattg                         38

<210> 8
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 8
tgatttgtgc gactttcagg ttagctaaag cgtc                             34

<210> 9
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 9
gaaagtcgac caaatcaaaa aagtccgact cctcattg                         38

<210> 10
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
tgatttggtc gactttcagg ttagctaaag cgtc                             34

<210> 11
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 11
agctcgcaca gtttgatgaa gaactttata agg                              33

<210> 12
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 12
aactgtgcga gctgtgccac ctcctgcatg acctcc                           36

<210> 13
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 13
agctcgacca gtttgatgaa gaactttata agg                              33

<210> 14
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 14
aactggtcga gctgtgccac ctcctgcatg acctcc                           36

<210> 15
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 15
gaaagtcgca cagattaaaa aagtccgact cctcattg                         38

<210> 16
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 16
taatctgtgc gactttcagg gcagctagcg cgtc                             34

<210> 17
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
gaaagtcgac cagattaaaa aagtccgact cctcattg                         38

<210> 18
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
taatctggtc gactttcagg gcagctagcg cgtc                             34

<210> 19
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
cagctcgccc agtttgatga agaactttat aaggtg                           36

<210> 20
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 20
caaactgggc gagctgggcc acttcctgca tg                               32

<210> 21
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 21
cagctcgacc agtttgatga agaactttat aaggtg                           36

<210> 22
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 22
caaactggtc gagctgggcc acttcctgca tg                               32

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 23
ggcataggga cccatcattg a                                           21

<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 24
gcatggagta tctcacaaag t                                           21

<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 25
taaggctatg aagagatac                                              19

<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 26
gagggcagaa tcatcacgaa g                                           21

<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 27
tgtgctgtag gaagctcatc tctc                                        24

<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 28
cgtcaccaac tgggacga                                               18

<210> 29
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 29
atgggggagg gcatacc                                                17

<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 30
ggctctcctc catctgtctg c                                           21

<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 31
cagtggtttt ctttctttgc tttg                                        24

<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 32
tcaccaccac agccgaaaga g                                           21

<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 33
gtcagcaatg ccagggtaca t                                           21

<210> 34
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 34
aggagaatgt gaacaaacct gacac                                       25

<210> 35
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 35
cctcttacct cagttacaat ttata                                       25

<210> 36
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 36
ggcggggcgg agccatgcgc ccccccc                                     27

<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 37
gggcggatgg gtaattttca                                             20

<210> 38
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 38
ctgcggacgc ccagtgaa                                               18

<210> 39
<211> 1545
<212> DNA
<213> Homo sapiens

<400> 39
atggtgctgg atctggattt gtttcgggtg gataaaggag gggacccagc cctcatccga 60
gagacgcagg agaagcgctt caaggacccg ggactagtgg accagctggt gaaggcagac 120
agcgagtggc gacgatgtag atttcgggca gacaacttga acaagctgaa gaacctatgc 180
agcaagacaa tcggagagaa aatgaagaaa aaagagccag tgggagatga tgagtctgtc 240
ccagagaatg tgctgagttt cgatgacctt actgcagacg ctttagctaa cctgaaagtc 300
tcacaaatca aaaaagtccg actcctcatt gatgaagcca tcctgaagtg tgacgcggag 360
cggataaagt tggaagcaga gcggtttgag aacctccgag agattgggaa ccttctgcac 420
ccttctgtac ccatcagtaa cgatgaggat gtggacaaca aagtagagag gatttggggt 480
gattgtacag tcaggaagaa gtactctcat gtggacctgg tggtgatggt agatggcttt 540
gaaggcgaaa agggggccgt ggtggctggg agtcgagggt acttcttgaa gggggtcctg 600
gtgttcctgg aacaggctct catccagtat gcccttcgca ccttgggaag tcggggctac 660
attcccattt ataccccctt tttcatgagg aaggaggtca tgcaggaggt ggcacagctc 720
agccagtttg atgaagaact ttataaggtg attggcaaag gcagtgaaaa gtctgatgac 780
aactcctatg atgagaagta cctgattgcc acctcagagc agcccattgc tgccctgcac 840
cgggatgagt ggctccggcc ggaggacctg cccatcaagt atgctggcct gtctacctgc 900
ttccgtcagg aggtgggctc ccatggccgt gacacccgtg gcatcttccg agtccatcag 960
tttgagaaga ttgaacagtt tgtgtactca tcaccccatg acaacaagtc atgggagatg 1020
tttgaagaga tgattaccac cgcagaggag ttctaccagt ccctggggat tccttaccac 1080
attgtgaata ttgtctcagg ttctttgaat catgctgcca gtaagaagct tgacctggag 1140
gcctggtttc cgggctcagg agccttccgt gagttggtct cctgttctaa ttgcacggat 1200
taccaggctc gccggcttcg aatccgatat gggcaaacca agaagatgat ggacaaggtg 1260
gagtttgtcc atatgctcaa tgctaccatg tgcgccacta cccgtaccat ctgcgccatc 1320
ctggagaact accagacaga gaagggcatc actgtgcctg agaaattgaa ggagttcatg 1380
ccgccaggac tgcaagaact gatccccttt gtgaagcctg cgcccattga gcaggagcca 1440
tcaaagaagc agaagaagca acatgagggc agcaaaaaga aagcagcagc aagagacgtc 1500
accctagaaa acaggctgca gaacatggag gtcaccgatg cttga                 1545

<210> 40
<211> 1545
<212> DNA
<213> Homo sapiens

<400> 40
atggtgctgg atctggattt gtttcgggtg gataaaggag gggacccagc cctcatccga 60
gagacgcagg agaagcgctt caaggacccg ggactagtgg accagctggt gaaggcagac 120
agcgagtggc gacgatgtag atttcgggca gacaacttga acaagctgaa gaacctatgc 180
agcaagacaa tcggagagaa aatgaagaaa aaagagccag tgggagatga tgagtctgtc 240
ccagagaatg tgctgagttt cgatgacctt actgcagacg ctttagctaa cctgaaagtc 300
gcvcaaatca aaaaagtccg actcctcatt gatgaagcca tcctgaagtg tgacgcggag 360
cggataaagt tggaagcaga gcggtttgag aacctccgag agattgggaa ccttctgcac 420
ccttctgtac ccatcagtaa cgatgaggat gtggacaaca aagtagagag gatttggggt 480
gattgtacag tcaggaagaa gtactctcat gtggacctgg tggtgatggt agatggcttt 540
gaaggcgaaa agggggccgt ggtggctggg agtcgagggt acttcttgaa gggggtcctg 600
gtgttcctgg aacaggctct catccagtat gcccttcgca ccttgggaag tcggggctac 660
attcccattt ataccccctt tttcatgagg aaggaggtca tgcaggaggt ggcacagctc 720
gcvcagtttg atgaagaact ttataaggtg attggcaaag gcagtgaaaa gtctgatgac 780
aactcctatg atgagaagta cctgattgcc acctcagagc agcccattgc tgccctgcac 840
cgggatgagt ggctccggcc ggaggacctg cccatcaagt atgctggcct gtctacctgc 900
ttccgtcagg aggtgggctc ccatggccgt gacacccgtg gcatcttccg agtccatcag 960
tttgagaaga ttgaacagtt tgtgtactca tcaccccatg acaacaagtc atgggagatg 1020
tttgaagaga tgattaccac cgcagaggag ttctaccagt ccctggggat tccttaccac 1080
attgtgaata ttgtctcagg ttctttgaat catgctgcca gtaagaagct tgacctggag 1140
gcctggtttc cgggctcagg agccttccgt gagttggtct cctgttctaa ttgcacggat 1200
taccaggctc gccggcttcg aatccgatat gggcaaacca agaagatgat ggacaaggtg 1260
gagtttgtcc atatgctcaa tgctaccatg tgcgccacta cccgtaccat ctgcgccatc 1320
ctggagaact accagacaga gaagggcatc actgtgcctg agaaattgaa ggagttcatg 1380
ccgccaggac tgcaagaact gatccccttt gtgaagcctg cgcccattga gcaggagcca 1440
tcaaagaagc agaagaagca acatgagggc agcaaaaaga aagcagcagc aagagacgtc 1500
accctagaaa acaggctgca gaacatggag gtcaccgatg cttga                 1545

<210> 41
<211> 1539
<212> DNA
<213> Mus musculus

<400> 41
atggtgctgg acctggattt gtttcgggtg gataaaggag gggacccagc cctcattcga 60
gagacgcagg agaagcgctt caaggacccg gggctggtgg accagctggt gaaagcagac 120
agtgagtggc gacgatgcag atttcgggca gacaacttga acaagctgaa gaatttatgc 180
agcaaaacta ttggggagaa aatgaagaaa aaggaagcag tgggagacga cgagtccgtc 240
ccagagaacg tgctgaattt cgatgacctc actgcagacg cgctagctgc cctgaaagtc 300
tcacagatta aaaaagtccg actcctcatt gatgaagcca tccagaagtg tgatggggag 360
cgggtaaagc tggaagcaga gcgatttgag aacctccgcg agattgggaa ccttctgcac 420
ccctctgtgc ccattagtaa tgatgaggac gcagacaaca aagtagaacg tatttgggga 480
gattgtacag tcaggaagaa gtattcccat gtggacctgg tggtgatggt agatggcttt 540
gaaggcgaaa agggagccgt ggtggctggt agtcgggggt acttcctgaa ggggcccctg 600
gtgttcctgg agcaggcgct tatccaatat gcactgcgta ccttggggag tcggggctac 660
actccaatct acaccccctt cttcatgagg aaagaggtca tgcaggaagt ggcccagctc 720
agccagtttg atgaagaact ttataaggtg attggcaaag gcagcgaaaa gtcagatgac 780
aactcctatg acgagaaata cttgattgcc acctcagagc agcccatcgc ggctctgcac 840
cgggacgagt ggctgcggcc agaggatctg cccatcaagt acgctggcct ctccacctgc 900
tttcgtcagg aagtgggctc gcatggccgt gacacccgtg gtatcttccg agtccatcag 960
tttgagaaga ttgagcagtt tgtgtactca tcgccccatg acaataagtc gtgggagatg 1020
tttgatgaga tgatcgccac cgcagaagaa ttctaccagt ctttggggat cccttaccac 1080
attgtgaata ttgtctcagg ctccttgaat cacgctgcca gtaagaagct cgacctggag 1140
gcctggttcc caggctcggg tgccttccgt gagttggtgt cctgttctaa ttgcacggat 1200
taccaagctc gccgcctgag aatccgatat gggcagacca agaagatgat ggacaaggtg 1260
gagtttgtcc atatgcttaa tgctacaatg tgtgctacca cccggaccat ctgcgccatc 1320
ctggagaact accaggcaga gaagggcatc gctgtgccag agaagttgag ggagttcatg 1380
ccgccagggc tccaagagct gatcccgttt gtgaagcctg cacccattga ccaggagcca 1440
tctaagaagc agaagaagca acatgaaggc agcaaaaaga aagcgaaaga ggtccccctg 1500
gagaaccagc tgcagagcat ggaggtcact gaggcctga                        1539

<210> 42
<211> 512
<212> PRT
<213> Mus musculus

<400> 42
Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe
        35                  40                  45              
Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Ala Val Gly Asp Asp Glu Ser Val
65                  70                  75                  80  
Pro Glu Asn Val Leu Asn Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala
                85                  90                  95      
Ala Leu Lys Val Ser Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu
            100                 105                 110         
Ala Ile Gln Lys Cys Asp Gly Glu Arg Val Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Ala Asp Asn Lys Val Glu Arg Ile Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Pro Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Thr Pro Ile Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu
        275                 280                 285             
Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys
                325                 330                 335     
Ser Trp Glu Met Phe Asp Glu Met Ile Ala Thr Ala Glu Glu Phe Tyr
            340                 345                 350         
Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Ala Glu Lys
        435                 440                 445             
Gly Ile Ala Val Pro Glu Lys Leu Arg Glu Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Asp Gln Glu Pro
465                 470                 475                 480 
Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Lys
                485                 490                 495     
Glu Val Pro Leu Glu Asn Gln Leu Gln Ser Met Glu Val Thr Glu Ala
            500                 505                 510         


<210> 43
<211> 1548
<212> DNA
<213> Danio rerio

<400> 43
atggtgctcg atttagacct gtttcgcacc gacaaaggcg gcgatcctga aattatccgg 60
gaaactcaga ggaaacggtt caaagatgtg tctctggtgg ataaactggt ccaggcggac 120
acagaatgga gaaaatgtcg tttcacagca gataacctta acaaggccaa gaatctctgc 180
agcaaatcca tcggtgaaaa gatgaagaag aaagagccag taggggatga tgacactctt 240
ccagaagagg ctcagaatct ggaagccctc actgcagaaa cgttatcgcc gcttactgtg 300
actcagataa agaaagtgcg ggttctggtg gatgaggctg tgcagaagac agacagtgac 360
cggctgaagc tggaggcaga gcgctttgag tatctgcgag agatcggcaa cctcctacat 420
ccctctgtgc ccatcagcaa cgatgaggat gctgataata aagtggagcg cacctggggt 480
gactgcacgg tgcagaagaa gtactctcat gtggacctgg tcgtcatggt tgatggatat 540
gagggggaaa aaggagccat tgttgctgga agcagaggat actttctcaa ggggccttta 600
gtgttcttgg agcaagcttt gattaactat gcgctgcgga tcctgtacag caagaactac 660
aacctcctgt acacaccctt cttcatgagg aaagaagtca tgcaggaggt cgctcagctc 720
agccagtttg acgaggagct ctacaaggtg atcgggaaag gaagtgagaa gtctgatgat 780
aacacagtgg acgagaagta cttgattgcc acatcagagc agccaatcgc agccttcctg 840
agagatgagt ggctgaagcc agaagaactt cctatccgct acgctggcct ctccacctgc 900
ttcagacagg aagtgggctc tcatggcaga gacacgcgcg ggatcttcag ggtccatcag 960
tttgagaaga ttgagcagtt tgtgtacgcc tctcctcatg atggcaaatc ctgggagatg 1020
tttgatgaaa tgattggaac cgctgaatcc ttttatcaaa cattaggaat tccttatcga 1080
attgtcaaca tcgtgtcagg tgctttgaac cacgcagcta gtaaaaagct ggatttagag 1140
gcttggtttc ctggttccca ggcttttaga gagcttgtgt catgctcaaa ctgtacagac 1200
tatcaggctc gtcgcttgcg gattcgatac gggcaaacta agaaaatgat ggacaaggct 1260
gagtttgtgc acatgctcaa tgccaccatg tgtgcgacca ctcgtgtcat ctgtgccatc 1320
ctggagaact tccaaacaga ggaaggcatc attgttccag aacccctcaa ggcattcatg 1380
cctccaggtt taacagaaat aattaagttt gtgaagccag cccccattga ccaggaaacc 1440
acaaagaagc agaagaaaca gcaggaagga ggaaagaaga agaaacatca gggcggcgat 1500
gctgatctag agaacaaagt ggagaacatg tctgtcaatg actcttag              1548

<210> 44
<211> 515
<212> PRT
<213> Danio rerio

<400> 44
Met Val Leu Asp Leu Asp Leu Phe Arg Thr Asp Lys Gly Gly Asp Pro
 1               5                  10                  15      
Glu Ile Ile Arg Glu Thr Gln Arg Lys Arg Phe Lys Asp Val Ser Leu
            20                  25                  30          
Val Asp Lys Leu Val Gln Ala Asp Thr Glu Trp Arg Lys Cys Arg Phe
        35                  40                  45              
Thr Ala Asp Asn Leu Asn Lys Ala Lys Asn Leu Cys Ser Lys Ser Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Asp Thr Leu
65                  70                  75                  80  
Pro Glu Glu Ala Gln Asn Leu Glu Ala Leu Thr Ala Glu Thr Leu Ser
                85                  90                  95      
Pro Leu Thr Val Thr Gln Ile Lys Lys Val Arg Val Leu Val Asp Glu
            100                 105                 110         
Ala Val Gln Lys Thr Asp Ser Asp Arg Leu Lys Leu Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Tyr Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro
    130                 135                 140                 
Ile Ser Asn Asp Glu Asp Ala Asp Asn Lys Val Glu Arg Thr Trp Gly
145                 150                 155                 160 
Asp Cys Thr Val Gln Lys Lys Tyr Ser His Val Asp Leu Val Val Met
                165                 170                 175     
Val Asp Gly Tyr Glu Gly Glu Lys Gly Ala Ile Val Ala Gly Ser Arg
            180                 185                 190         
Gly Tyr Phe Leu Lys Gly Pro Leu Val Phe Leu Glu Gln Ala Leu Ile
        195                 200                 205             
Asn Tyr Ala Leu Arg Ile Leu Tyr Ser Lys Asn Tyr Asn Leu Leu Tyr
    210                 215                 220                 
Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu
225                 230                 235                 240 
Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu
                245                 250                 255     
Lys Ser Asp Asp Asn Thr Val Asp Glu Lys Tyr Leu Ile Ala Thr Ser
            260                 265                 270         
Glu Gln Pro Ile Ala Ala Phe Leu Arg Asp Glu Trp Leu Lys Pro Glu
        275                 280                 285             
Glu Leu Pro Ile Arg Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu
    290                 295                 300                 
Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln
305                 310                 315                 320 
Phe Glu Lys Ile Glu Gln Phe Val Tyr Ala Ser Pro His Asp Gly Lys
                325                 330                 335     
Ser Trp Glu Met Phe Asp Glu Met Ile Gly Thr Ala Glu Ser Phe Tyr
            340                 345                 350         
Gln Thr Leu Gly Ile Pro Tyr Arg Ile Val Asn Ile Val Ser Gly Ala
        355                 360                 365             
Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro
    370                 375                 380                 
Gly Ser Gln Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp
385                 390                 395                 400 
Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met
                405                 410                 415     
Met Asp Lys Ala Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala
            420                 425                 430         
Thr Thr Arg Val Ile Cys Ala Ile Leu Glu Asn Phe Gln Thr Glu Glu
        435                 440                 445             
Gly Ile Ile Val Pro Glu Pro Leu Lys Ala Phe Met Pro Pro Gly Leu
    450                 455                 460                 
Thr Glu Ile Ile Lys Phe Val Lys Pro Ala Pro Ile Asp Gln Glu Thr
465                 470                 475                 480 
Thr Lys Lys Gln Lys Lys Gln Gln Glu Gly Gly Lys Lys Lys Lys His
                485                 490                 495     
Gln Gly Gly Asp Ala Asp Leu Glu Asn Lys Val Glu Asn Met Ser Val
            500                 505                 510         
Asn Asp Ser
        515 


<210> 45
<211> 1536
<212> DNA
<213> Xenopus tropicalis

<400> 45
atggttctag atttggatct tttccgggag gacaagggag gaaacccgga gctcatcaga 60
gagactcaga gaaagagatt taaggacccg gggctggtgg atgcattgct gaactcagac 120
acggcctgga gaaagtgcag gtttcaggca gacaatctta ataaacagaa aaatctttgc 180
agcaaaatca tcggggagaa aatgaagaaa aaggagccgt tgggagacag tgatgttctt 240
cctgaaaata tccagcttga ccagctaact gctgaagttc ttagtgctct gtcagttaca 300
cagataaaaa gactccgggt cttaatagat gaagccatag cagcaactga cacagaacgt 360
atcaagctgg aggctgagag gtttgaaagt ttacgtgaga ttggaaacct gcttcaccca 420
acagtgccta tcagtaacga tgaggacaat gataataagg tggaacgcac ttggggagac 480
tgtgaagttc gaaagagata ctcacatgtg gaccttgtgg ttatggtgga tggctttgag 540
ggggaaaaag gagctgtagt agctggtagc agaggatatt tcttaaaggg tcctctggtg 600
tttctagagc aggccctcat acagtttgct ttgcataccc tggcagaaaa gcaatacacc 660
cccatatata ccccattttt catgagaaaa gaggtcatgc aggaggtggc tcagctcagt 720
caatttgatg aagaactgta caaggtgata ggtaaaggta gtgagaaatc tgatgataac 780
tccatagatg agaagtacct aatagccact tcagaacagc caatagctgc attacatcgg 840
gatgagtggc tgaagcctga agagttgcct ctacgatatg ctggcatatc aacttgtttc 900
cgtcaggaag tgggctccca tggaagagac acaagaggca tatttagagt acaccagttt 960
gagaagattg agcagtttat ttatgcctca cctaatgata acaagtcctg ggaattgttt 1020
gaagaaatga ttatgacagc tgaatcattt taccagaagc ttggcattcc ctatcgtatt 1080
gtgaatattg tttcaggctc cttgaaccac gctgccagta aaaagctgga tttagaggcc 1140
tggtttcctg gctcaggtgc attcagagag ctggtctctt gttcaaactg cactgactac 1200
caagcccggc ggctacggat ccgatatggg cagacaaaga agatgatgga caaggtagag 1260
tttgtacaca tgttaaatgc caccatgtgt gccacgaccc gtgcaatttg tgcaattcta 1320
gagaactatc aaaccgagga agggataatt ataccagaga aactcaggga ctttatgcct 1380
ccaggtctga attatataat aaagtttgta aaaccagctc caattgacca ggaactcacc 1440
aaaaaacaga agaagcagca gcaggaaaaa ggaaagaaaa cagaaaattg tggtttagat 1500
aatcaaatgg agaacatgaa agttaattca gcttaa                           1536

<210> 46
<211> 511
<212> PRT
<213> Xenopus tropicalis

<400> 46
Met Val Leu Asp Leu Asp Leu Phe Arg Glu Asp Lys Gly Gly Asn Pro
 1               5                  10                  15      
Glu Leu Ile Arg Glu Thr Gln Arg Lys Arg Phe Lys Asp Pro Gly Leu
            20                  25                  30          
Val Asp Ala Leu Leu Asn Ser Asp Thr Ala Trp Arg Lys Cys Arg Phe
        35                  40                  45              
Gln Ala Asp Asn Leu Asn Lys Gln Lys Asn Leu Cys Ser Lys Ile Ile
    50                  55                  60                  
Gly Glu Lys Met Lys Lys Lys Glu Pro Leu Gly Asp Ser Asp Val Leu
65                  70                  75                  80  
Pro Glu Asn Ile Gln Leu Asp Gln Leu Thr Ala Glu Val Leu Ser Ala
                85                  90                  95      
Leu Ser Val Thr Gln Ile Lys Arg Leu Arg Val Leu Ile Asp Glu Ala
            100                 105                 110         
Ile Ala Ala Thr Asp Thr Glu Arg Ile Lys Leu Glu Ala Glu Arg Phe
        115                 120                 125             
Glu Ser Leu Arg Glu Ile Gly Asn Leu Leu His Pro Thr Val Pro Ile
    130                 135                 140                 
Ser Asn Asp Glu Asp Asn Asp Asn Lys Val Glu Arg Thr Trp Gly Asp
145                 150                 155                 160 
Cys Glu Val Arg Lys Arg Tyr Ser His Val Asp Leu Val Val Met Val
                165                 170                 175     
Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg Gly
            180                 185                 190         
Tyr Phe Leu Lys Gly Pro Leu Val Phe Leu Glu Gln Ala Leu Ile Gln
        195                 200                 205             
Phe Ala Leu His Thr Leu Ala Glu Lys Gln Tyr Thr Pro Ile Tyr Thr
    210                 215                 220                 
Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu Ser
225                 230                 235                 240 
Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu Lys
                245                 250                 255     
Ser Asp Asp Asn Ser Ile Asp Glu Lys Tyr Leu Ile Ala Thr Ser Glu
            260                 265                 270         
Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Lys Pro Glu Glu
        275                 280                 285             
Leu Pro Leu Arg Tyr Ala Gly Ile Ser Thr Cys Phe Arg Gln Glu Val
    290                 295                 300                 
Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln Phe
305                 310                 315                 320 
Glu Lys Ile Glu Gln Phe Ile Tyr Ala Ser Pro Asn Asp Asn Lys Ser
                325                 330                 335     
Trp Glu Leu Phe Glu Glu Met Ile Met Thr Ala Glu Ser Phe Tyr Gln
            340                 345                 350         
Lys Leu Gly Ile Pro Tyr Arg Ile Val Asn Ile Val Ser Gly Ser Leu
        355                 360                 365             
Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro Gly
    370                 375                 380                 
Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp Tyr
385                 390                 395                 400 
Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met Met
                405                 410                 415     
Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala Thr
            420                 425                 430         
Thr Arg Ala Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Glu Gly
        435                 440                 445             
Ile Ile Ile Pro Glu Lys Leu Arg Asp Phe Met Pro Pro Gly Leu Asn
    450                 455                 460                 
Tyr Ile Ile Lys Phe Val Lys Pro Ala Pro Ile Asp Gln Glu Leu Thr
465                 470                 475                 480 
Lys Lys Gln Lys Lys Gln Gln Gln Glu Lys Gly Lys Lys Thr Glu Asn
                485                 490                 495     
Cys Gly Leu Asp Asn Gln Met Glu Asn Met Lys Val Asn Ser Ala
            500                 505                 510     

