                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev, LTD
 
<110>  B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY

<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF BONE ASSOCIATED 
       DISEASES

<130>  NIBN-P-016

<150>  IL247369
<151>  2016-08-18

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is any amino acid other than cysteine

<400>  1

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Xaa Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Glu Pro Val Arg Gly Asp Asn Ile Asn 
65                  70                  75                  80  


Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu 
                85                  90                  95      


Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val 
            100                 105                 110         


Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn 
        115                 120                 125             


Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe 
    130                 135                 140                 


Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser 
145                 150                 155         


<210>  2
<211>  158
<212>  PRT
<213>  Aritficial

<400>  2

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Ser Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
145                 150                 155             


<210>  3
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp 
            20                  


<210>  4
<211>  31
<212>  PRT
<213>  Aritficial

<400>  4

Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
1               5                   10                  15      


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
            20                  25                  30      


<210>  5
<211>  77
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu 
1               5                   10                  15      


Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val 
            20                  25                  30          


Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn 
        35                  40                  45              


Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe 
    50                  55                  60                  


Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser 
65                  70                  75          


<210>  6
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Arg Gly Asp 
1           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(9)
<223>  X is any amino acid

<400>  7

Xaa Xaa Xaa Arg Gly Asp Xaa Xaa Xaa 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Gln Thr Ser Arg Gly Asp Ser Pro Ser 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Thr Tyr Pro Arg Gly Asp Met Cys Ser 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Glu Pro Val Arg Gly Asp Asn Ile Asn 
1               5                   


<210>  11
<211>  157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is Arg, His or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is any amino acid other than Cysteine

<400>  11

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Xaa Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Glu Pro Val Arg Gly Asp Asn Ile Asn 
65                  70                  75                  80  


Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu 
                85                  90                  95      


Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val 
            100                 105                 110         


Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn 
        115                 120                 125             


Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe 
    130                 135                 140                 


Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser 
145                 150                 155         


<210>  12
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Gln Thr Pro Arg Gly Asp Ser Pro 
            20                  25                  30          


Ser Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                  40                  45              


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                  55                  60                  


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser 
145                 


<210>  13
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  13

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Thr Tyr Pro Arg Gly Asp Met Cys 
            20                  25                  30          


Ser Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                  40                  45              


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                  55                  60                  


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser 
145                 


<210>  14
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Ser Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Glu 
    50                  55                  60                  


Pro Val Arg Gly Asp Asn Ile Asn Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser 
145                 


<210>  15
<211>  157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  15

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Arg Glu Thr Ser Ser Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Glu Pro Val Arg Gly Asp Asn Ile Asn 
65                  70                  75                  80  


Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu 
                85                  90                  95      


Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val 
            100                 105                 110         


Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn 
        115                 120                 125             


Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe 
    130                 135                 140                 


Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser 
145                 150                 155         


<210>  16
<211>  457
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is Gln or Thr

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is Thr or Tyr

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is Seq or Met

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is Pro or Cys

<400>  16

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Xaa Xaa Xaa Arg Gly Asp Xaa Xaa 
            20                  25                  30          


Ser Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                  40                  45              


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                  55                  60                  


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys 
145                 150                 155                 160 


Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro 
                165                 170                 175     


His Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp 
            180                 185                 190         


Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln 
        195                 200                 205             


Pro Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg 
    210                 215                 220                 


Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp 
225                 230                 235                 240 


Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe 
                245                 250                 255     


Asn Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp 
            260                 265                 270         


Val Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln 
        275                 280                 285             


Gly Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr 
    290                 295                 300                 


Glu Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro 
305                 310                 315                 320 


Ala Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu 
                325                 330                 335     


Pro Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr 
            340                 345                 350         


Pro Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu 
        355                 360                 365             


Pro Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn 
    370                 375                 380                 


Pro Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser 
385                 390                 395                 400 


Gly Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg 
                405                 410                 415     


Asp Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly 
            420                 425                 430         


Ala Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr 
        435                 440                 445             


Gly His Glu Arg Gln Ser Glu Gly Ser 
    450                 455         


<210>  17
<211>  457
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  17

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Ser Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Glu 
    50                  55                  60                  


Pro Val Arg Gly Asp Asn Ile Asn Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys 
145                 150                 155                 160 


Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro 
                165                 170                 175     


His Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp 
            180                 185                 190         


Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln 
        195                 200                 205             


Pro Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg 
    210                 215                 220                 


Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp 
225                 230                 235                 240 


Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe 
                245                 250                 255     


Asn Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp 
            260                 265                 270         


Val Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln 
        275                 280                 285             


Gly Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr 
    290                 295                 300                 


Glu Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro 
305                 310                 315                 320 


Ala Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu 
                325                 330                 335     


Pro Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr 
            340                 345                 350         


Pro Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu 
        355                 360                 365             


Pro Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn 
    370                 375                 380                 


Pro Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser 
385                 390                 395                 400 


Gly Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg 
                405                 410                 415     


Asp Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly 
            420                 425                 430         


Ala Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr 
        435                 440                 445             


Gly His Glu Arg Gln Ser Glu Gly Ser 
    450                 455         


<210>  18
<211>  158
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
145                 150                 155             


<210>  19
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (25)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Xaa Xaa Xaa Arg Gly Asp Xaa Xaa 
            20                  25                  30          


Xaa Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                  40                  45              


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                  55                  60                  


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
145                 150                 155                 


