                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Altieri, Dario C
 
<120>  METHODS OF DETECTING AND TREATING A TUMOR EXPRESSING PT346 PDK1

<130>  17643-5004WO

<140>  PCT/US17/45513
<141>  2017-08-04

<150>  62/400,314
<151>  2016-09-27

<150>  62/371,804
<151>  2016-08-07

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human PDK1

<400>  1

Met Arg Leu Ala Arg Leu Leu Arg Gly Ala Ala Leu Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Leu Arg Ala Ala Gly Phe Ser Arg Ser Phe Ser Ser Asp Ser 
            20                  25                  30          


Gly Ser Ser Pro Ala Ser Glu Arg Gly Val Pro Gly Gln Val Asp Phe 
        35                  40                  45              


Tyr Ala Arg Phe Ser Pro Ser Pro Leu Ser Met Lys Gln Phe Leu Asp 
    50                  55                  60                  


Phe Gly Ser Val Asn Ala Cys Glu Lys Thr Ser Phe Met Phe Leu Arg 
65                  70                  75                  80  


Gln Glu Leu Pro Val Arg Leu Ala Asn Ile Met Lys Glu Ile Ser Leu 
                85                  90                  95      


Leu Pro Asp Asn Leu Leu Arg Thr Pro Ser Val Gln Leu Val Gln Ser 
            100                 105                 110         


Trp Tyr Ile Gln Ser Leu Gln Glu Leu Leu Asp Phe Lys Asp Lys Ser 
        115                 120                 125             


Ala Glu Asp Ala Lys Ala Ile Tyr Asp Phe Thr Asp Thr Val Ile Arg 
    130                 135                 140                 


Ile Arg Asn Arg His Asn Asp Val Ile Pro Thr Met Ala Gln Gly Val 
145                 150                 155                 160 


Ile Glu Tyr Lys Glu Ser Phe Gly Val Asp Pro Val Thr Ser Gln Asn 
                165                 170                 175     


Val Gln Tyr Phe Leu Asp Arg Phe Tyr Met Ser Arg Ile Ser Ile Arg 
            180                 185                 190         


Met Leu Leu Asn Gln His Ser Leu Leu Phe Gly Gly Lys Gly Lys Gly 
        195                 200                 205             


Ser Pro Ser His Arg Lys His Ile Gly Ser Ile Asn Pro Asn Cys Asn 
    210                 215                 220                 


Val Leu Glu Val Ile Lys Asp Gly Tyr Glu Asn Ala Arg Arg Leu Cys 
225                 230                 235                 240 


Asp Leu Tyr Tyr Ile Asn Ser Pro Glu Leu Glu Leu Glu Glu Leu Asn 
                245                 250                 255     


Ala Lys Ser Pro Gly Gln Pro Ile Gln Val Val Tyr Val Pro Ser His 
            260                 265                 270         


Leu Tyr His Met Val Phe Glu Leu Phe Lys Asn Ala Met Arg Ala Thr 
        275                 280                 285             


Met Glu His His Ala Asn Arg Gly Val Tyr Pro Pro Ile Gln Val His 
    290                 295                 300                 


Val Thr Leu Gly Asn Glu Asp Leu Thr Val Lys Met Ser Asp Arg Gly 
305                 310                 315                 320 


Gly Gly Val Pro Leu Arg Lys Ile Asp Arg Leu Phe Asn Tyr Met Tyr 
                325                 330                 335     


Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
            340                 345                 350         


Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr Ala Gln Tyr 
        355                 360                 365             


Phe Gln Gly Asp Leu Lys Leu Tyr Ser Leu Glu Gly Tyr Gly Thr Asp 
    370                 375                 380                 


Ala Val Ile Tyr Ile Lys Ala Leu Ser Thr Asp Ser Ile Glu Arg Leu 
385                 390                 395                 400 


Pro Val Tyr Asn Lys Ala Ala Trp Lys His Tyr Asn Thr Asn His Glu 
                405                 410                 415     


Ala Asp Asp Trp Cys Val Pro Ser Arg Glu Pro Lys Asp Met Thr Thr 
            420                 425                 430         


Phe Arg Ser Ala 
        435     


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK1 phosphorylated T346 chymotryptic peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  phosphorylation

<400>  2

Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
1               5                   10                  15      


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK1 non-phosphorylated T346 chymotryptic peptide

<400>  3

Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
1               5                   10                  


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human PDK1

<400>  4
cgtgaatatg ttgaagtaga a                                                 21


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  phosphorylated PDK1 peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  phosphorylated

<400>  5

Cys Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu Ala 
1               5                   10                  15      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK1

<400>  6

Tyr Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro 
1               5                   10                  15      


Leu Ala Gly Phe Gly 
            20      


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK2

<400>  7

Tyr Ser Thr Ala Pro Thr Pro Gln Pro Gly Thr Gly Gly Thr Pro Leu 
1               5                   10                  15      


Ala Gly Phe Gly 
            20  


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK2

<400>  8

Tyr Ser Thr Ala Pro Arg Pro Ser Leu Glu Pro Thr Arg Ala Ala Pro 
1               5                   10                  15      


Leu Ala Gly Phe Gly 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK4

<400>  9

Tyr Ser Thr Ala Pro Thr Pro Val Met Asp Asn Ser Arg Asn Ala Pro 
1               5                   10                  15      


Leu Ala Gly Phe Gly 
            20      


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDK1

<400>  10

Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu Ala 
1               5                   10                  15  


