<110>  ϴѧ
 
<120>  һ½ɫ֦˾ԴͪC27-øӦ

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  1275
<212>  DNA
<213>  ˹

<400>  1
atgaccgaca ccgcccacgc ccggcagccc aacattcctc ccggtttcga tttcaccgat     60
ccggacatct acgctcaccg gctgcccatc gaggaattcg ccgaaatgcg ccgggtggcg    120
cccatctggt ggaacgaaca accggcagaa aagggcggct tcggcgatgg cgggtactgg    180
gtcgtcacca agcacagaga cgtcaaggag gtttcgcggc gcagcgacgt cttctccagc    240
ctggccaaga ccgcgctgcc gcgttatgcc gacggcacgg tcaaggaaca gatcgacaca    300
ggcaagttcg tcctgctgaa catggacgcc ccgcatcaca cccacctgcg caagatcatc    360
tcccgcgcct tcactccgcg cgccatcgag ctgttgcgcg cagacctggc cgaacgggcc    420
cgcgagatcg ctgccagggc ggccgcggcc gggtcgggcg atttcgtcga acaggtgtcc    480
tgcgaattgc cgctgcaggc catcgccggg ctgatgggtg ttcctcagga agaccggatg    540
aagctgttcc actggtccaa ccagatggtc ggcgacatgg accccgagtt cgccggtaac    600
gacgccatca gcgcgtcggt cgagctgatc acctatggca tgaagctggc cgccgaacgc    660
gccgactccc ccggtgagga cctggtcacc aagctggtgc aggccgatgt cgaggggcac    720
aagctcaccg acgacgaact cgggttcttc gtggttctgc tcgccgttgc gggtaacgag    780
acgacgcgca actcgatcac ccaggggatg atggcgttca ccgacttccc ggatcagtgg    840
gagctgttca agcgggagcg gccgtcgacg acggccgacg agatcgtccg gtgggccaca    900
ccggtgacat cgtttcagcg caccgctctc gccgacaccg aactgtccgg ggtgtcgatc    960
aaaaagggtc agcgcgtggt gatgatgtac cgcgcagcca atttcgacga ggatgttttc   1020
gaggatccgt acacgttcga catcctgcgt gacccgaacc cccatgtcgg cttcggcggc   1080
accggggcgc attactgcat cggcaccagc ctcgcccgga tgaccatcga tctgatgttc   1140
aacgcgatcg ccgacgcgat gcccgacatc acctcgctgg cccagcccga acggttgcgg   1200
tccggctggc tcaatggcat caaacactgg caggtcgact acgtgggcgc gtcgaaacag   1260
gctgtgcacc actag                                                    1275


<210>  2
<211>  1236
<212>  DNA
<213>  ˹

<400>  2
atgacgacga tggatgcgtg tccgttcggt gcggggtacg acttcaccga ccccgaggtg     60
ctgctgcagg ggcttccggt cacggagttc gcccacctgc gcaagaccgc accgatctgg    120
tggaacgccc agggtgagtc gatcttcgat gacggcggct attgggtgat cagccggcac    180
gaagacgtca agaccatctc ccgcaactcc cgcgacatct ggtccaccaa tgccaaggga    240
gcggtcatgc ggctgcccga cggcatcacc gccgaccaac tcgatctgac caaggccctg    300
ctgatcaatc acgacgcccc ggagcacacc cggctgcgca agctggtctc gcgcctgttc    360
acgccgcgct cggtggccgc gctcgaggag aagctggcgg tggcggcacg cgagatcgtg    420
gcacgggccg ccgaacgcgg ctccggcaat ttcgtcgatg acgtggcgat gccgctgccg    480
ctacaggcca tcgccgacct gatcggggtg cccgaggcgg accgggagaa gatattccac    540
tggtcgaact gcatcatgaa caccgacgac cccgatttcg acagcgaccc gacgaccgcc    600
aacgcggagc tgatgggtta cgcctacaac atggccgaac aacgccggaa gtgcccggcc    660
gatgacatcg tcacccgcct ggtccaggcc gatctgggcg gagaagaggg catcaccgaa    720
gtggagttcg ccttcttcgt gatcctgctg gccgtggcag gcaatgagac cacccgcaat    780
acgatgaccc acgggatgaa cgccttcctc gaaaacccgg atcaatggga acttttcaag    840
cgtgagcgcc ccgataccgc catcgaggag atcatccggt gggccagccc ggtgcactgc    900
ttccagcgca cggcgctcca ggacaccgag atcggcgggg tcaccatcaa gcaaggccag    960
cgggtcgggc tgttctacag ctcggcaaac tacgacgaat ccgtgttcac cgacccgttc   1020
cggttcgaca tcctgcgcaa cccgaatccg catctggcct tcggtggcaa cggcgcacat   1080
ttctgcatcg gcgccaacct ggcccgcatg gagatcaagc tgatgttcaa cgagatcgcc   1140
aaccagatcc cggacatctc caaactggct gaaccgcagc gccttcgatc cggctggatc   1200
aacggcgtga aggaactgca ggtttcctac tcctga                             1236


<210>  3
<211>  1254
<212>  DNA
<213>  ˹

<400>  3
atgcccagcc ccaacctgcc caagggcttc gacccgctgg acgccagtct gaacctcgaa     60
cgcctgcccg tggaggagtt ggcggagatt cgccgcgccg agcccgtcca ctgggtggac    120
gtgccggaag ggaccggggg cttcggcgac aagggctact ggatcgtcac caagcatgcc    180
gacgtcaaag aggtctcgaa gcgaaacgac atcttcggca gctcacccga cggcgccatc    240
ccggtctggc cgcaggagat gacccgcgac gccatcgatc tgcagaaggc cgtcctgctc    300
aacatggacg cgccgcagca cacccggttg cgcaagatca tctcgcgcgg gttcaccccg    360
cgcgccatcg gacggctcga agacgagttg cgggcccgtg cccgcaagat cgccgaaacc    420
gcggcggcag ccggttcggg cgacttcgtc gagcaggtgt cctgcgaact gccgctgcag    480
gccatcgccg aactgctcgg tgtgccgcag gacgaccggg acaagatctt ccgctggtcc    540
aatgagatga ctgcgggcga ggaccccgag tacgccgatg tcgatccggc gatgtcctcc    600
ttcgagctca tcacctacgc catgaagatg gccgaggagc gggcgcagaa cccgaccgag    660
gacatcgtga ccaagctgat cgaggccgat atcgagggcg agaagctctc tgacgacgag    720
ttcggtttct tcgtggtcat gcttgccgtc gcaggcaacg agaccacccg caactcgatc    780
acccacggca tgatcgcctt cgccgacaat cccgaccagt gggagctcta caagaaggaa    840
cgcccgggca ccgccgccga cgagatcatc cgttgggcga caccggtgtc ggcgttccag    900
cgcacggcac tggaggacac cgagctcgcc ggggcgaaga tcaagaaggg cgatcgtgtg    960
gtgatgtcct accgcgccgc caacttcgac gacgaggcgt tcgacaaccc gcaccagttc   1020
aacatcctgc gtgatcccaa cccgcacgtc ggattcggtg gtaccggtgc gcactactgt   1080
atcggcgcaa acctggcccg catgaccatc aacctgatct tcaacgcgat cgccgacgtg   1140
atgcccgaca tcacaccgat cggcgagccg gagcggttga agtccggctg gctcaacgga   1200
atcaagcact ggcaggtcga ctacaccggc gcgggcgccg gcgcctcgag ctag         1254


<210>  4
<211>  424
<212>  PRT
<213>  ˹

<400>  4
Met Thr Asp Thr Ala His Ala Arg Gln Pro Asn Ile Pro Pro Gly Phe 
1               5                   10                  15      
Asp Phe Thr Asp Pro Asp Ile Tyr Ala His Arg Leu Pro Ile Glu Glu 
            20                  25                  30          
Phe Ala Glu Met Arg Arg Val Ala Pro Ile Trp Trp Asn Glu Gln Pro 
        35                  40                  45              
Ala Glu Lys Gly Gly Phe Gly Asp Gly Gly Tyr Trp Val Val Thr Lys 
    50                  55                  60                  
His Arg Asp Val Lys Glu Val Ser Arg Arg Ser Asp Val Phe Ser Ser 
65                  70                  75                  80  
Leu Ala Lys Thr Ala Leu Pro Arg Tyr Ala Asp Gly Thr Val Lys Glu 
                85                  90                  95      
Gln Ile Asp Thr Gly Lys Phe Val Leu Leu Asn Met Asp Ala Pro His 
            100                 105                 110         
His Thr His Leu Arg Lys Ile Ile Ser Arg Ala Phe Thr Pro Arg Ala 
        115                 120                 125             
Ile Glu Leu Leu Arg Ala Asp Leu Ala Glu Arg Ala Arg Glu Ile Ala 
    130                 135                 140                 
Ala Arg Ala Ala Ala Ala Gly Ser Gly Asp Phe Val Glu Gln Val Ser 
145                 150                 155                 160 
Cys Glu Leu Pro Leu Gln Ala Ile Ala Gly Leu Met Gly Val Pro Gln 
                165                 170                 175     
Glu Asp Arg Met Lys Leu Phe His Trp Ser Asn Gln Met Val Gly Asp 
            180                 185                 190         
Met Asp Pro Glu Phe Ala Gly Asn Asp Ala Ile Ser Ala Ser Val Glu 
        195                 200                 205             
Leu Ile Thr Tyr Gly Met Lys Leu Ala Ala Glu Arg Ala Asp Ser Pro 
    210                 215                 220                 
Gly Glu Asp Leu Val Thr Lys Leu Val Gln Ala Asp Val Glu Gly His 
225                 230                 235                 240 
Lys Leu Thr Asp Asp Glu Leu Gly Phe Phe Val Val Leu Leu Ala Val 
                245                 250                 255     
Ala Gly Asn Glu Thr Thr Arg Asn Ser Ile Thr Gln Gly Met Met Ala 
            260                 265                 270         
Phe Thr Asp Phe Pro Asp Gln Trp Glu Leu Phe Lys Arg Glu Arg Pro 
        275                 280                 285             
Ser Thr Thr Ala Asp Glu Ile Val Arg Trp Ala Thr Pro Val Thr Ser 
    290                 295                 300                 
Phe Gln Arg Thr Ala Leu Ala Asp Thr Glu Leu Ser Gly Val Ser Ile 
305                 310                 315                 320 
Lys Lys Gly Gln Arg Val Val Met Met Tyr Arg Ala Ala Asn Phe Asp 
                325                 330                 335     
Glu Asp Val Phe Glu Asp Pro Tyr Thr Phe Asp Ile Leu Arg Asp Pro 
            340                 345                 350         
Asn Pro His Val Gly Phe Gly Gly Thr Gly Ala His Tyr Cys Ile Gly 
        355                 360                 365             
Thr Ser Leu Ala Arg Met Thr Ile Asp Leu Met Phe Asn Ala Ile Ala 
    370                 375                 380                 
Asp Ala Met Pro Asp Ile Thr Ser Leu Ala Gln Pro Glu Arg Leu Arg 
385                 390                 395                 400 
Ser Gly Trp Leu Asn Gly Ile Lys His Trp Gln Val Asp Tyr Val Gly 
                405                 410                 415     
Ala Ser Lys Gln Ala Val His His 
            420                 


<210>  5
<211>  411
<212>  PRT
<213>  ˹

<400>  5
Met Thr Thr Met Asp Ala Cys Pro Phe Gly Ala Gly Tyr Asp Phe Thr 
1               5                   10                  15      
Asp Pro Glu Val Leu Leu Gln Gly Leu Pro Val Thr Glu Phe Ala His 
            20                  25                  30          
Leu Arg Lys Thr Ala Pro Ile Trp Trp Asn Ala Gln Gly Glu Ser Ile 
        35                  40                  45              
Phe Asp Asp Gly Gly Tyr Trp Val Ile Ser Arg His Glu Asp Val Lys 
    50                  55                  60                  
Thr Ile Ser Arg Asn Ser Arg Asp Ile Trp Ser Thr Asn Ala Lys Gly 
65                  70                  75                  80  
Ala Val Met Arg Leu Pro Asp Gly Ile Thr Ala Asp Gln Leu Asp Leu 
                85                  90                  95      
Thr Lys Ala Leu Leu Ile Asn His Asp Ala Pro Glu His Thr Arg Leu 
            100                 105                 110         
Arg Lys Leu Val Ser Arg Leu Phe Thr Pro Arg Ser Val Ala Ala Leu 
        115                 120                 125             
Glu Glu Lys Leu Ala Val Ala Ala Arg Glu Ile Val Ala Arg Ala Ala 
    130                 135                 140                 
Glu Arg Gly Ser Gly Asn Phe Val Asp Asp Val Ala Met Pro Leu Pro 
145                 150                 155                 160 
Leu Gln Ala Ile Ala Asp Leu Ile Gly Val Pro Glu Ala Asp Arg Glu 
                165                 170                 175     
Lys Ile Phe His Trp Ser Asn Cys Ile Met Asn Thr Asp Asp Pro Asp 
            180                 185                 190         
Phe Asp Ser Asp Pro Thr Thr Ala Asn Ala Glu Leu Met Gly Tyr Ala 
        195                 200                 205             
Tyr Asn Met Ala Glu Gln Arg Arg Lys Cys Pro Ala Asp Asp Ile Val 
    210                 215                 220                 
Thr Arg Leu Val Gln Ala Asp Leu Gly Gly Glu Glu Gly Ile Thr Glu 
225                 230                 235                 240 
Val Glu Phe Ala Phe Phe Val Ile Leu Leu Ala Val Ala Gly Asn Glu 
                245                 250                 255     
Thr Thr Arg Asn Thr Met Thr His Gly Met Asn Ala Phe Leu Glu Asn 
            260                 265                 270         
Pro Asp Gln Trp Glu Leu Phe Lys Arg Glu Arg Pro Asp Thr Ala Ile 
        275                 280                 285             
Glu Glu Ile Ile Arg Trp Ala Ser Pro Val His Cys Phe Gln Arg Thr 
    290                 295                 300                 
Ala Leu Gln Asp Thr Glu Ile Gly Gly Val Thr Ile Lys Gln Gly Gln 
305                 310                 315                 320 
Arg Val Gly Leu Phe Tyr Ser Ser Ala Asn Tyr Asp Glu Ser Val Phe 
                325                 330                 335     
Thr Asp Pro Phe Arg Phe Asp Ile Leu Arg Asn Pro Asn Pro His Leu 
            340                 345                 350         
Ala Phe Gly Gly Asn Gly Ala His Phe Cys Ile Gly Ala Asn Leu Ala 
        355                 360                 365             
Arg Met Glu Ile Lys Leu Met Phe Asn Glu Ile Ala Asn Gln Ile Pro 
    370                 375                 380                 
Asp Ile Ser Lys Leu Ala Glu Pro Gln Arg Leu Arg Ser Gly Trp Ile 
385                 390                 395                 400 
Asn Gly Val Lys Glu Leu Gln Val Ser Tyr Ser 
                405                 410     


<210>  6
<211>  417
<212>  PRT
<213>  ˹

<400>  6
Met Pro Ser Pro Asn Leu Pro Lys Gly Phe Asp Pro Leu Asp Ala Ser 
1               5                   10                  15      
Leu Asn Leu Glu Arg Leu Pro Val Glu Glu Leu Ala Glu Ile Arg Arg 
            20                  25                  30          
Ala Glu Pro Val His Trp Val Asp Val Pro Glu Gly Thr Gly Gly Phe 
        35                  40                  45              
Gly Asp Lys Gly Tyr Trp Ile Val Thr Lys His Ala Asp Val Lys Glu 
    50                  55                  60                  
Val Ser Lys Arg Asn Asp Ile Phe Gly Ser Ser Pro Asp Gly Ala Ile 
65                  70                  75                  80  
Pro Val Trp Pro Gln Glu Met Thr Arg Asp Ala Ile Asp Leu Gln Lys 
                85                  90                  95      
Ala Val Leu Leu Asn Met Asp Ala Pro Gln His Thr Arg Leu Arg Lys 
            100                 105                 110         
Ile Ile Ser Arg Gly Phe Thr Pro Arg Ala Ile Gly Arg Leu Glu Asp 
        115                 120                 125             
Glu Leu Arg Ala Arg Ala Arg Lys Ile Ala Glu Thr Ala Ala Ala Ala 
    130                 135                 140                 
Gly Ser Gly Asp Phe Val Glu Gln Val Ser Cys Glu Leu Pro Leu Gln 
145                 150                 155                 160 
Ala Ile Ala Glu Leu Leu Gly Val Pro Gln Asp Asp Arg Asp Lys Ile 
                165                 170                 175     
Phe Arg Trp Ser Asn Glu Met Thr Ala Gly Glu Asp Pro Glu Tyr Ala 
            180                 185                 190         
Asp Val Asp Pro Ala Met Ser Ser Phe Glu Leu Ile Thr Tyr Ala Met 
        195                 200                 205             
Lys Met Ala Glu Glu Arg Ala Gln Asn Pro Thr Glu Asp Ile Val Thr 
    210                 215                 220                 
Lys Leu Ile Glu Ala Asp Ile Glu Gly Glu Lys Leu Ser Asp Asp Glu 
225                 230                 235                 240 
Phe Gly Phe Phe Val Val Met Leu Ala Val Ala Gly Asn Glu Thr Thr 
                245                 250                 255     
Arg Asn Ser Ile Thr His Gly Met Ile Ala Phe Ala Asp Asn Pro Asp 
            260                 265                 270         
Gln Trp Glu Leu Tyr Lys Lys Glu Arg Pro Gly Thr Ala Ala Asp Glu 
        275                 280                 285             
Ile Ile Arg Trp Ala Thr Pro Val Ser Ala Phe Gln Arg Thr Ala Leu 
    290                 295                 300                 
Glu Asp Thr Glu Leu Ala Gly Ala Lys Ile Lys Lys Gly Asp Arg Val 
305                 310                 315                 320 
Val Met Ser Tyr Arg Ala Ala Asn Phe Asp Asp Glu Ala Phe Asp Asn 
                325                 330                 335     
Pro His Gln Phe Asn Ile Leu Arg Asp Pro Asn Pro His Val Gly Phe 
            340                 345                 350         
Gly Gly Thr Gly Ala His Tyr Cys Ile Gly Ala Asn Leu Ala Arg Met 
        355                 360                 365             
Thr Ile Asn Leu Ile Phe Asn Ala Ile Ala Asp Val Met Pro Asp Ile 
    370                 375                 380                 
Thr Pro Ile Gly Glu Pro Glu Arg Leu Lys Ser Gly Trp Leu Asn Gly 
385                 390                 395                 400 
Ile Lys His Trp Gln Val Asp Tyr Thr Gly Ala Gly Ala Gly Ala Ser 
                405                 410                 415     
Ser 