                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
       RACIOPPI, Luigi
       NELSON, Erik
       HUANG, Wei
       CHAO, Nelson
       MCDONNELL, Donald
 
<120>  CAMKK2 INHIBITOR COMPOSITIONS AND METHODS OF USING THE SAME

<130>  5667-00411 PCT

<150>  US 62/371,309
<151>  2016-08-05

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  588
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(588)
<223>  Human CaMKK2 (Calcium-Calmodulin kinase kinase 2) Protein

<400>  1

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210>  2
<211>  588
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(588)
<223>  Mouse CaMKK2 Protein

<400>  2

Met Ser Ser Cys Val Ser Ser Gln Pro Thr Ser Asp Arg Val Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Ser Gly Gly Gly Ser Arg Glu Gly Gln Lys Pro 
            20                  25                  30          


Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly Met 
        35                  40                  45              


Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Arg Gly Val Asp 
    50                  55                  60                  


Leu Asn Leu Ala Arg Asp Gln Pro Pro Glu Ala Asp Gly Gln Glu Leu 
65                  70                  75                  80  


Pro Leu Glu Ala Ser Asp Pro Glu Ser Arg Ser Pro Leu Ser Gly Arg 
                85                  90                  95      


Lys Met Ser Leu Gln Glu Pro Ser Gln Gly Gly Pro Ala Ser Ser Ser 
            100                 105                 110         


Asn Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Ser Tyr 
        115                 120                 125             


Ser Pro Ala Ser Ser Pro Gln Ser Ser Pro Arg Met Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Leu Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Ala Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Trp Glu Pro Leu 
        515                 520                 525             


Ser Glu Pro Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly Pro Arg 
    530                 535                 540                 


Ala Gly Pro Cys Gly Gly Gly Gly Ser Ala Leu Val Lys Gly Gly Pro 
545                 550                 555                 560 


Cys Val Glu Ser Trp Gly Ala Pro Ala Pro Gly Ser Pro Pro Arg Met 
                565                 570                 575     


Pro Pro Leu Gln Pro Glu Glu Val Met Glu Pro Glu 
            580                 585             


<210>  3
<211>  587
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(587)
<223>  Rat CaMKK2 Protein

<400>  3

Met Ser Ser Cys Val Ser Ser Gln Pro Thr Ser Asp Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Ser Gly Gly Val Ser Arg Glu Ser Gln Lys Pro 
            20                  25                  30          


Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly Met 
        35                  40                  45              


Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Arg Gly Val Asp 
    50                  55                  60                  


Leu Ser Leu Ala Arg Asp Gln Pro Leu Glu Ala Asp Gly Gln Glu Leu 
65                  70                  75                  80  


Pro Leu Asp Ala Ser Glu Pro Glu Ser Arg Ser Leu Leu Ser Gly Gly 
                85                  90                  95      


Lys Met Ser Leu Gln Glu Arg Ser Gln Gly Gly Pro Ala Ser Ser Ser 
            100                 105                 110         


Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Ser Tyr Ser 
        115                 120                 125             


Pro Ala Ser Ser Pro Gln Ser Ser Pro Arg Met Pro Arg Arg Pro Thr 
    130                 135                 140                 


Val Glu Ser His His Val Ser Ile Thr Gly Leu Gln Asp Cys Val Gln 
145                 150                 155                 160 


Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr Gly 
                165                 170                 175     


Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala Met 
            180                 185                 190         


Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro Arg 
        195                 200                 205             


Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile Gln 
    210                 215                 220                 


Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu Lys 
225                 230                 235                 240 


Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp Asp 
                245                 250                 255     


Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln Gly 
            260                 265                 270         


Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln Ala 
        275                 280                 285             


Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His Tyr 
    290                 295                 300                 


Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val Gly 
305                 310                 315                 320 


Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu Phe 
                325                 330                 335     


Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala Phe 
            340                 345                 350         


Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly Lys 
        355                 360                 365             


Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val Phe 
    370                 375                 380                 


Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser Lys 
385                 390                 395                 400 


Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala Glu 
                405                 410                 415     


Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu Ser 
            420                 425                 430         


Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg His 
        435                 440                 445             


Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val Glu 
    450                 455                 460                 


Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser Leu 
465                 470                 475                 480 


Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe Gly 
                485                 490                 495     


Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala Pro 
            500                 505                 510         


Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Trp Glu Pro Leu Ser 
        515                 520                 525             


Glu Pro Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly Pro Arg Ala 
    530                 535                 540                 


Ser Pro Cys Gly Gly Gly Gly Ser Ala Leu Val Lys Gly Gly Pro Cys 
545                 550                 555                 560 


Val Glu Ser Cys Gly Ala Pro Ala Pro Gly Ser Pro Pro Arg Thr Pro 
                565                 570                 575     


Pro Gln Gln Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585         


<210>  4
<211>  578
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(578)
<223>  Dog CaMKK2 Protein

<400>  4

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asp Pro Ala Ala Leu 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Gly Ser Gly Ser Glu Gly Gln Lys Pro Cys 
            20                  25                  30          


Glu Ala Leu Gln Gly Leu Ser Ser Leu Ser Ile Arg Leu Gly Met Glu 
        35                  40                  45              


Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val Asp Arg 
    50                  55                  60                  


Gly Leu Ser Arg Asp Arg Pro Arg Glu Ala Glu Gly Arg Lys Val Pro 
65                  70                  75                  80  


Leu Asp Ala Ser Ala Ser Gly Ser Gln Ala Arg Pro Gln Leu Cys Ser 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Leu Asp Ala Asn Gly Arg 
            100                 105                 110         


Cys Val His Pro Val Leu Pro His Ser Pro Val Gly Ser Pro Gln Ser 
        115                 120                 125             


Ser Pro Arg Leu Pro Arg Arg Pro Thr Val Glu Ser His His Val Ser 
    130                 135                 140                 


Ile Thr Gly Met Gln Asp Cys Val Gln Leu Asn Gln Tyr Thr Leu Lys 
145                 150                 155                 160 


Asp Glu Ile Gly Lys Gly Ser Tyr Gly Val Val Lys Leu Ala Tyr Asn 
                165                 170                 175     


Glu Asn Asp Asn Thr Tyr Tyr Ala Met Lys Val Leu Ser Lys Lys Lys 
            180                 185                 190         


Leu Ile Arg Gln Ala Gly Phe Pro Arg Arg Pro Pro Pro Arg Gly Thr 
        195                 200                 205             


Arg Leu Ala Pro Gly Gly Cys Ile Gln Pro Arg Gly Pro Ile Glu Gln 
    210                 215                 220                 


Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His Pro Asn Val 
225                 230                 235                 240 


Val Lys Leu Val Glu Val Leu Asp Asp Pro Asn Glu Asp His Leu Tyr 
                245                 250                 255     


Met Val Phe Glu Leu Val Asn Gln Gly Pro Val Met Glu Val Pro Thr 
            260                 265                 270         


Leu Lys Pro Leu Ser Glu Asp Gln Ala Arg Phe Tyr Phe Gln Asp Leu 
        275                 280                 285             


Ile Lys Gly Ile Glu Tyr Leu His Tyr Gln Lys Ile Ile His Arg Asp 
    290                 295                 300                 


Ile Lys Pro Ser Asn Leu Leu Val Gly Glu Asp Gly His Ile Lys Ile 
305                 310                 315                 320 


Ala Asp Phe Gly Val Ser Asn Glu Phe Lys Gly Ser Asp Ala Leu Leu 
                325                 330                 335     


Ser Asn Thr Val Gly Thr Pro Ala Phe Met Ala Pro Glu Ser Leu Ser 
            340                 345                 350         


Glu Thr Arg Lys Ile Phe Ser Gly Lys Ala Leu Asp Val Trp Ala Met 
        355                 360                 365             


Gly Val Thr Leu Tyr Cys Phe Val Phe Gly Gln Cys Pro Phe Met Asp 
    370                 375                 380                 


Glu Arg Ile Met Cys Leu His Ser Lys Ile Lys Ser Gln Ala Leu Glu 
385                 390                 395                 400 


Phe Pro Asp Gln Pro Asp Ile Ala Glu Asp Leu Lys Asp Leu Ile Thr 
                405                 410                 415     


Arg Met Leu Asp Lys Asn Pro Glu Ser Arg Ile Val Val Pro Glu Ile 
            420                 425                 430         


Lys Leu His Pro Trp Val Thr Arg His Gly Ala Glu Pro Leu Pro Ser 
        435                 440                 445             


Glu Asp Glu Asn Cys Thr Leu Val Glu Val Thr Glu Glu Glu Val Glu 
    450                 455                 460                 


Asn Ser Val Lys His Ile Pro Ser Leu Ala Thr Val Ile Leu Val Lys 
465                 470                 475                 480 


Thr Met Ile Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg 
                485                 490                 495     


Arg Glu Glu Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys Lys 
            500                 505                 510         


Pro Thr Arg Glu Cys Glu Pro Leu Ser Glu Pro Lys Glu Ala Arg Gln 
        515                 520                 525             


Arg Arg Gln Pro Pro Gly Pro Arg Pro Gly Pro Arg Gly Gly Gly Gly 
    530                 535                 540                 


Ser Ala Leu Val Lys Gly Gly Pro Cys Thr Glu Ser Trp Gly Ala Pro 
545                 550                 555                 560 


Ala Pro Gly Pro Arg Ala Arg Met His Pro Leu Arg Pro Asp Glu Ala 
                565                 570                 575     


Met Glu 
        


<210>  5
<211>  578
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(578)
<223>  Cat CaMKK2 Protein

<400>  5

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asp Arg Ala Ala Leu 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Gly Ala Ser Ser Glu Gly Gln Lys Pro Cys 
            20                  25                  30          


Glu Ala Leu Gln Gly Leu Ser Ser Leu Ser Ile Arg Leu Gly Met Glu 
        35                  40                  45              


Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val Asp Arg 
    50                  55                  60                  


Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu Val Pro 
65                  70                  75                  80  


Leu His Ala Ser Ala Ser Gly Ser Gln Val Arg Pro Gln Leu Cys Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Leu Asp Ala Asn Gly Arg 
            100                 105                 110         


Cys Val His Pro Ala Leu Ser His Ser Pro Val Gly Ser Pro Gln Ser 
        115                 120                 125             


Ser Pro Arg Leu Pro Arg Arg Pro Thr Val Glu Ser His His Val Ser 
    130                 135                 140                 


Ile Thr Gly Met Gln Asp Cys Val Gln Leu Asn Gln Tyr Thr Leu Lys 
145                 150                 155                 160 


Asp Glu Ile Gly Lys Gly Ser Tyr Gly Val Val Lys Leu Ala Tyr Asn 
                165                 170                 175     


Glu Asn Asp Asn Thr Tyr Tyr Ala Met Lys Val Leu Ser Lys Lys Lys 
            180                 185                 190         


Leu Ile Arg Gln Ala Gly Phe Pro Arg Arg Pro Pro Pro Arg Gly Thr 
        195                 200                 205             


Arg Pro Ala Pro Gly Gly Cys Ile Gln Pro Arg Gly Pro Ile Glu Gln 
    210                 215                 220                 


Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His Pro Asn Val 
225                 230                 235                 240 


Val Lys Leu Val Glu Val Leu Asp Asp Pro Asn Glu Asp His Leu Tyr 
                245                 250                 255     


Met Val Phe Glu Leu Val Asn Gln Gly Pro Val Met Glu Val Pro Thr 
            260                 265                 270         


Leu Lys Pro Leu Ser Glu Asp Gln Ala Arg Phe Tyr Phe Gln Asp Leu 
        275                 280                 285             


Ile Lys Gly Ile Glu Tyr Leu His Tyr Gln Lys Ile Ile His Arg Asp 
    290                 295                 300                 


Ile Lys Pro Ser Asn Leu Leu Val Gly Glu Asp Gly His Ile Lys Ile 
305                 310                 315                 320 


Ala Asp Phe Gly Val Ser Asn Glu Phe Lys Gly Ser Asp Ala Leu Leu 
                325                 330                 335     


Ser Asn Thr Val Gly Thr Pro Ala Phe Met Ala Pro Glu Ser Leu Ser 
            340                 345                 350         


Glu Thr Arg Lys Ile Phe Ser Gly Lys Ala Leu Asp Val Trp Ala Met 
        355                 360                 365             


Gly Val Thr Leu Tyr Cys Phe Val Phe Gly Gln Cys Pro Phe Met Asp 
    370                 375                 380                 


Glu Arg Ile Met Cys Leu His Ser Lys Ile Lys Ser Gln Ala Leu Glu 
385                 390                 395                 400 


Phe Pro Asp Gln Pro Asp Ile Ala Glu Asp Leu Lys Asp Leu Ile Thr 
                405                 410                 415     


Arg Met Leu Asp Lys Asn Pro Glu Ser Arg Ile Val Val Pro Glu Ile 
            420                 425                 430         


Lys Leu His Pro Trp Val Thr Arg His Gly Ala Glu Pro Leu Pro Ser 
        435                 440                 445             


Glu Asp Glu Asn Cys Thr Leu Val Glu Val Thr Glu Glu Glu Val Glu 
    450                 455                 460                 


Asn Ser Val Lys His Ile Pro Ser Leu Ala Thr Val Ile Leu Val Lys 
465                 470                 475                 480 


Thr Met Ile Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg 
                485                 490                 495     


Arg Glu Glu Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys Lys 
            500                 505                 510         


Pro Thr Arg Glu Cys Glu Pro Leu Ser Glu Pro Lys Glu Ala Arg Gln 
        515                 520                 525             


Arg Arg Gln Pro Pro Gly Pro Arg Pro Ala Pro Arg Gly Gly Gly Gly 
    530                 535                 540                 


Ser Ala Leu Val Lys Gly Gly Pro Arg Ala Glu Ser Trp Gly Ala Pro 
545                 550                 555                 560 


Ala Pro Gly Pro Arg Ala Arg Met His Pro Leu Arg Pro Asp Glu Ala 
                565                 570                 575     


Met Glu 
        


<210>  6
<211>  583
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (1)..(583)
<223>  Rabbit CaMKK2 Protein

<400>  6

Met Ser Ser Cys Ile Ser Ser Gln Pro Ser Gly Asp Pro Ala Ala Pro 
1               5                   10                  15      


Gln Asp Asp Leu Gly Gly Gly Gly Ser Ser Ile Glu Gly Gln Lys Ser 
            20                  25                  30          


Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile Arg Leu Gly Met 
        35                  40                  45              


Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Arg Ala Val Asp 
    50                  55                  60                  


Leu Ser Leu Ala Gln Asp Gln Gly Pro Leu Glu Ala Asp Gly Pro Glu 
65                  70                  75                  80  


Val Pro Leu Asp Ala Ser Ala Ser Gln Ala Arg Pro His Leu Cys Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Arg Leu Ala Ala Ser 
            100                 105                 110         


Ser Ser Leu Asp Met Asn Gly Arg Cys Ile His Pro Ser Val Pro Tyr 
        115                 120                 125             


Ser Pro Ala Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Pro Leu 
        515                 520                 525             


Ser Glu Pro Lys Glu Ala Arg Gln Arg Arg Arg Gln Pro Pro Gly His 
    530                 535                 540                 


Arg Pro His Pro Arg Ile Val Lys Gly Gly Pro Arg Ala Gly Ser Trp 
545                 550                 555                 560 


Gly Ala Ala Ala Pro Gly Gly Pro Ala His Met His Pro Leu Trp Pro 
                565                 570                 575     


Glu Glu Ala Thr Glu Pro Gln 
            580             


<210>  7
<211>  565
<212>  PRT
<213>  Cavia porcellus


<220>
<221>  misc_feature
<222>  (1)..(565)
<223>  Cavia CaMKK2 Protein

<400>  7

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asp Arg Ala Thr Pro 
1               5                   10                  15      


Gln Asp Gly Ser His Glu Gly Pro Lys Pro Cys Glu Ala Leu Gln Gly 
            20                  25                  30          


Leu Ser Ser Leu Ser Leu Arg Leu Gly Met Glu Ser Phe Ile Val Val 
        35                  40                  45              


Thr Glu Cys Glu Pro Asn His Ala Gly Asp Leu Ser Leu Ala Arg Asp 
    50                  55                  60                  


His Pro Leu Asp Ala Ser Arg Ser His Leu Ser Gly Arg Lys Leu Ser 
65                  70                  75                  80  


Leu Gln Glu Arg Ser Ser Gly Ala Pro Val Val Gly Ser Ser Pro Glu 
                85                  90                  95      


Thr Asp Gly His Cys Ile His Pro Ala Leu Pro Cys Ser Pro Val Gly 
            100                 105                 110         


Ser Pro Gln Leu Ser Pro Arg Leu Pro Arg Arg Pro Thr Val Glu Ser 
        115                 120                 125             


His His Val Ser Ile Thr Gly Leu Gln Asp Cys Val Gln Leu Asn Gln 
    130                 135                 140                 


Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr Gly Val Val Lys 
145                 150                 155                 160 


Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala Met Lys Val Leu 
                165                 170                 175     


Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro Arg Glu Cys Gly 
            180                 185                 190         


Pro Ala Gly Trp Asn Ser Gly Gln Lys Glu Pro Phe Ser Pro Ser Gly 
        195                 200                 205             


Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp 
    210                 215                 220                 


His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp Asp Pro Asn Glu 
225                 230                 235                 240 


Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln Gly Pro Val Met 
                245                 250                 255     


Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln Ala Arg Phe Tyr 
            260                 265                 270         


Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His Phe Gln Lys Ile 
        275                 280                 285             


Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val Gly Asp Asp Gly 
    290                 295                 300                 


His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu Phe Lys Gly Ser 
305                 310                 315                 320 


Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala Phe Met Ala Pro 
                325                 330                 335     


Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly Lys Ala Leu Asp 
            340                 345                 350         


Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val Phe Gly Gln Cys 
        355                 360                 365             


Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser Lys Ile Lys Ser 
    370                 375                 380                 


Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala Glu Asp Leu Lys 
385                 390                 395                 400 


Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu Ser Arg Ile Val 
                405                 410                 415     


Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg His Gly Ala Glu 
            420                 425                 430         


Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val Glu Val Thr Glu 
        435                 440                 445             


Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser Leu Ala Thr Val 
    450                 455                 460                 


Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe Gly Asn Pro Phe 
465                 470                 475                 480 


Asp Gly Ser Arg Arg Glu Glu Arg Ala Leu Ser Ala Pro Gly Asn Leu 
                485                 490                 495     


Leu Thr Lys Lys Pro Pro Arg Glu Trp Glu Pro Leu Ser Glu Pro Lys 
            500                 505                 510         


Glu Ala Lys Gln Arg Arg Gln Pro Ala Gly Ser Arg Pro Cys Pro Arg 
        515                 520                 525             


Gly Gly Gly Gly Gly Ser Ala Leu Leu Lys Gly Gly Pro Cys Thr Glu 
    530                 535                 540                 


Ser Trp Gly Ala Ala Arg Thr His Arg Pro Gln Pro Gln Gly Glu Glu 
545                 550                 555                 560 


Ala Met Glu Pro Gln 
                565 


<210>  8
<211>  570
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<222>  (1)..(570)
<223>  Sheep CaMKK2 Protein

<400>  8

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asp Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Gly Gly Gly Ser Ser Ser Ser Glu Gly Gln 
            20                  25                  30          


Lys Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile Arg Leu 
        35                  40                  45              


Gly Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Ala Cys Ala 
    50                  55                  60                  


Val Asp His Gly Leu Thr Arg Asp Arg Pro Leu Glu Ala His Gly Gly 
65                  70                  75                  80  


Glu Ile Thr Leu Asp Ala Ser Gly Ser Gln Ala Arg Pro His Leu Ser 
                85                  90                  95      


Ser Arg Lys Leu Ser Leu Gln Glu Arg Ser Leu Leu Asp Ala Asn Gly 
            100                 105                 110         


Arg Cys Val Tyr Pro Ala Leu Pro His Ser Pro Val Gly Ser Pro Gln 
        115                 120                 125             


Ser Ser Pro Arg Leu His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
    130                 135                 140                 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
145                 150                 155                 160 


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
                165                 170                 175     


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
            180                 185                 190         


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
        195                 200                 205             


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
    210                 215                 220                 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
225                 230                 235                 240 


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
                245                 250                 255     


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
            260                 265                 270         


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
        275                 280                 285             


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
    290                 295                 300                 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
305                 310                 315                 320 


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
                325                 330                 335     


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
            340                 345                 350         


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
        355                 360                 365             


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
    370                 375                 380                 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
385                 390                 395                 400 


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
                405                 410                 415     


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
            420                 425                 430         


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
        435                 440                 445             


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
    450                 455                 460                 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
465                 470                 475                 480 


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
                485                 490                 495     


Pro Gly Asn Leu Leu Ser Lys Lys Pro Thr Arg Glu Cys Glu Pro Leu 
            500                 505                 510         


Ser Glu Pro Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly Pro Arg 
        515                 520                 525             


Thr Gly Pro Arg Arg Gly Gly Gly Ser Ala Leu Met Lys Gly Gly Pro 
    530                 535                 540                 


Gly Val Glu Ser Trp Gly Val Pro Gly Pro Ser Ser Leu Glu His Thr 
545                 550                 555                 560 


His Pro Ala Arg Pro Asp Glu Val Met Glu 
                565                 570 


<210>  9
<211>  525
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<222>  (1)..(525)
<223>  Sheep CaMKK2 Protein

<400>  9

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asp Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Gly Gly Gly Ser Ser Ser Ser Glu Gly Gln 
            20                  25                  30          


Lys Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile Arg Leu 
        35                  40                  45              


Gly Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Ala Cys Ala 
    50                  55                  60                  


Val Asp His Gly Leu Thr Arg Asp Arg Pro Leu Glu Ala His Gly Gly 
65                  70                  75                  80  


Glu Ile Thr Leu Asp Ala Ser Gly Ser Gln Ala Arg Pro His Leu Ser 
                85                  90                  95      


Ser Arg Lys Leu Ser Leu Gln Glu Arg Ser Leu Leu Asp Ala Asn Gly 
            100                 105                 110         


Arg Cys Val Tyr Pro Ala Leu Pro His Ser Pro Val Gly Ser Pro Gln 
        115                 120                 125             


Ser Ser Pro Arg Leu His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
    130                 135                 140                 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
145                 150                 155                 160 


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
                165                 170                 175     


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
            180                 185                 190         


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
        195                 200                 205             


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
    210                 215                 220                 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
225                 230                 235                 240 


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
                245                 250                 255     


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
            260                 265                 270         


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
        275                 280                 285             


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
    290                 295                 300                 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
305                 310                 315                 320 


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
                325                 330                 335     


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
            340                 345                 350         


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
        355                 360                 365             


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
    370                 375                 380                 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
385                 390                 395                 400 


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
                405                 410                 415     


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
            420                 425                 430         


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
        435                 440                 445             


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
    450                 455                 460                 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
465                 470                 475                 480 


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
                485                 490                 495     


Pro Gly Asn Leu Leu Arg Lys Gln Gly Ser Glu Asp Ser Leu Gln Gly 
            500                 505                 510         


Pro Glu Pro Ala Pro Val Gly Glu Glu Glu Val Leu Ser 
        515                 520                 525 


<210>  10
<211>  579
<212>  PRT
<213>  Bos taurus


<220>
<221>  misc_feature
<222>  (1)..(579)
<223>  Bovine CaMKK2 Protein

<400>  10

Met Ser Ser Cys Ile Ser Ser Gln Pro Ser Ser Asp Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Gly Gly Gly Ser Ser Ser Ser Glu Gly Gln 
            20                  25                  30          


Lys Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile Arg Leu 
        35                  40                  45              


Gly Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Val Cys Ala 
    50                  55                  60                  


Val Asp His Gly Leu Thr Arg Asp Arg Pro Leu Glu Ala His Gly Gly 
65                  70                  75                  80  


Glu Ile Thr Leu Asp Ala Ser Gly Ser Gln Ala Arg Pro His Leu Ser 
                85                  90                  95      


Gly Arg Lys Leu Ser Leu Gln Glu Arg Ser Leu Leu Asp Ala Asn Gly 
            100                 105                 110         


Arg Cys Val Tyr Pro Ala Leu Pro His Ser Pro Val Gly Ser Pro Gln 
        115                 120                 125             


Ser Ser Pro Arg Leu Pro Arg Arg Pro Thr Val Glu Ser His His Val 
    130                 135                 140                 


Ser Ile Thr Gly Met Gln Asp Cys Val Gln Leu Asn Gln Tyr Thr Leu 
145                 150                 155                 160 


Lys Asp Glu Ile Gly Lys Gly Ser Tyr Gly Val Val Lys Leu Ala Tyr 
                165                 170                 175     


Asn Glu Asn Asp Asn Thr Tyr Tyr Ala Met Lys Val Leu Ser Lys Lys 
            180                 185                 190         


Lys Leu Ile Arg Gln Ala Gly Phe Pro Arg Arg Pro Pro Pro Arg Gly 
        195                 200                 205             


Thr Arg Pro Ala Pro Gly Gly Cys Ile Gln Pro Arg Gly Pro Ile Glu 
    210                 215                 220                 


Gln Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His Pro Asn 
225                 230                 235                 240 


Val Val Lys Leu Val Glu Val Leu Asp Asp Pro Asn Glu Asp His Leu 
                245                 250                 255     


Tyr Met Val Phe Glu Leu Val Asn Gln Gly Pro Val Met Glu Val Pro 
            260                 265                 270         


Thr Leu Lys Pro Leu Ser Glu Asp Gln Ala Arg Phe Tyr Phe Gln Asp 
        275                 280                 285             


Leu Ile Lys Gly Ile Glu Tyr Leu His Tyr Gln Lys Ile Ile His Arg 
    290                 295                 300                 


Asp Ile Lys Pro Ser Asn Leu Leu Val Gly Glu Asp Gly His Ile Lys 
305                 310                 315                 320 


Ile Ala Asp Phe Gly Val Ser Asn Glu Phe Lys Gly Ser Asp Ala Leu 
                325                 330                 335     


Leu Ser Asn Thr Val Gly Thr Pro Ala Phe Met Ala Pro Glu Ser Leu 
            340                 345                 350         


Ser Glu Thr Arg Lys Ile Phe Ser Gly Lys Ala Leu Asp Val Trp Ala 
        355                 360                 365             


Met Gly Val Thr Leu Tyr Cys Phe Val Phe Gly Gln Cys Pro Phe Met 
    370                 375                 380                 


Asp Glu Arg Ile Met Cys Leu His Ser Lys Ile Lys Ser Gln Ala Leu 
385                 390                 395                 400 


Glu Phe Pro Asp Gln Pro Asp Ile Ala Glu Asp Leu Lys Asp Leu Ile 
                405                 410                 415     


Thr Arg Met Leu Asp Lys Asn Pro Glu Ser Arg Ile Val Val Pro Glu 
            420                 425                 430         


Ile Lys Leu His Pro Trp Val Thr Arg His Gly Ala Glu Pro Leu Pro 
        435                 440                 445             


Ser Glu Asp Glu Asn Cys Thr Leu Val Glu Val Thr Glu Glu Glu Val 
    450                 455                 460                 


Glu Asn Ser Val Lys His Ile Pro Ser Leu Ala Thr Val Ile Leu Val 
465                 470                 475                 480 


Lys Thr Met Ile Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser 
                485                 490                 495     


Arg Arg Glu Glu Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Gly Lys 
            500                 505                 510         


Lys Pro Thr Arg Glu Cys Glu Pro Leu Ser Glu Pro Lys Glu Ala Arg 
        515                 520                 525             


Gln Arg Arg Gln Pro Pro Gly Pro Arg Thr Gly Pro Arg Arg Gly Arg 
    530                 535                 540                 


Gly Ser Ala Leu Met Lys Gly Gly Pro Gly Val Glu Ser Trp Gly Val 
545                 550                 555                 560 


Pro Gly Pro Cys Ser Leu Glu His Thr His Pro Ala Arg Pro Asp Glu 
                565                 570                 575     


Val Met Glu 
            


<210>  11
<211>  423
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(423)
<223>  Horse CaMKK2 Protein

<400>  11

Pro Val Arg Pro His Phe Ser Gly Arg Lys Leu Ser Leu Gln Glu Arg 
1               5                   10                  15      


Ser Gln Leu Asp Ala Asn Gly Arg Cys Leu Ser Pro Arg Leu Pro Arg 
            20                  25                  30          


Arg Pro Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp 
        35                  40                  45              


Cys Val Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly 
    50                  55                  60                  


Ser Tyr Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly 
                85                  90                  95      


Phe Pro Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly 
            100                 105                 110         


Cys Ile Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala 
        115                 120                 125             


Ile Leu Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val 
    130                 135                 140                 


Leu Asp Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val 
145                 150                 155                 160 


Asn Gln Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu 
                165                 170                 175     


Asp Gln Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr 
            180                 185                 190         


Leu His Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu 
        195                 200                 205             


Leu Val Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser 
    210                 215                 220                 


Asn Glu Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr 
225                 230                 235                 240 


Pro Ala Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe 
                245                 250                 255     


Ser Gly Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys 
            260                 265                 270         


Phe Val Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu 
        275                 280                 285             


His Ser Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp 
    290                 295                 300                 


Ile Ala Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn 
305                 310                 315                 320 


Pro Glu Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val 
                325                 330                 335     


Thr Arg His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr 
            340                 345                 350         


Leu Val Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile 
        355                 360                 365             


Pro Ser Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg 
    370                 375                 380                 


Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu 
385                 390                 395                 400 


Ser Ala Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu 
                405                 410                 415     


Pro Leu Ser Glu Pro Lys Thr 
            420             


<210>  12
<211>  8
<212>  PRT
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Ovalbumin peptide 257-264

<400>  12

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDH-F

<400>  13
cctggagaaa cctgccaagt atg                                               23


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDG-R

<400>  14
agagtgggag ttgctgttga agtc                                              24


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mARG1-F

<400>  15
gcaaggtgat ggaagagac                                                    19


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mARG1-R

<400>  16
catcgacatc aaagctcagg                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mNOS2-F

<400>  17
gcaaacatca cattcagatc cc                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mNOS2-R

<400>  18
tcagcctcat ggtaaacacg                                                   20


<210>  19
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mCAMKK2-F

<400>  19
catgaatgga cgctgc                                                       16


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mCAMKK2-R

<400>  20
tgacaacgcc ataggagcc                                                    19


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mCAT-F

<400>  21
cggcacatga atggctatgg atc                                               23


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mCAT-R

<400>  22
aagccttcct gcctctccaa ca                                                22


