                         SEQUENCE LISTING

<110>  JOSLIN DIABETES CENTER, INC.
        
<120>  METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIA

<130>  123968-03020

<140>  
<141>  2017-08-02

<150>  US 62/370,532
<151>  2016-08-03

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  2157
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2157)
<223>  Homo sapiens fibroblast growth factor 19 (FGF19), mRNA

<400>  1
gctcccagcc aagaacctcg gggccgctgc gcggtgggga ggagttcccc gaaacccggc       60

cgctaagcga ggcctcctcc tcccgcagat ccgaacggcc tgggcggggt caccccggct      120

gggacaagaa gccgccgcct gcctgcccgg gcccggggag ggggctgggg ctggggccgg      180

aggcggggtg tgagtgggtg tgtgcggggg gcggaggctt gatgcaatcc cgataagaaa      240

tgctcgggtg tcttgggcac ctacccgtgg ggcccgtaag gcgctactat ataaggctgc      300

cggcccggag ccgccgcgcc gtcagagcag gagcgctgcg tccaggatct agggccacga      360

ccatcccaac ccggcactca cagccccgca gcgcatcccg gtcgccgccc agcctcccgc      420

acccccatcg ccggagctgc gccgagagcc ccagggaggt gccatgcgga gcgggtgtgt      480

ggtggtccac gtatggatcc tggccggcct ctggctggcc gtggccgggc gccccctcgc      540

cttctcggac gcggggcccc acgtgcacta cggctggggc gaccccatcc gcctgcggca      600

cctgtacacc tccggccccc acgggctctc cagctgcttc ctgcgcatcc gtgccgacgg      660

cgtcgtggac tgcgcgcggg gccagagcgc gcacagtttg ctggagatca aggcagtcgc      720

tctgcggacc gtggccatca agggcgtgca cagcgtgcgg tacctctgca tgggcgccga      780

cggcaagatg caggggctgc ttcagtactc ggaggaagac tgtgctttcg aggaggagat      840

ccgcccagat ggctacaatg tgtaccgatc cgagaagcac cgcctcccgg tctccctgag      900

cagtgccaaa cagcggcagc tgtacaagaa cagaggcttt cttccactct ctcatttcct      960

gcccatgctg cccatggtcc cagaggagcc tgaggacctc aggggccact tggaatctga     1020

catgttctct tcgcccctgg agaccgacag catggaccca tttgggcttg tcaccggact     1080

ggaggccgtg aggagtccca gctttgagaa gtaactgaga ccatgcccgg gcctcttcac     1140

tgctgccagg ggctgtggta cctgcagcgt gggggacgtg cttctacaag aacagtcctg     1200

agtccacgtt ctgtttagct ttaggaagaa acatctagaa gttgtacata ttcagagttt     1260

tccattggca gtgccagttt ctagccaata gacttgtctg atcataacat tgtaagcctg     1320

tagcttgccc agctgctgcc tgggccccca ttctgctccc tcgaggttgc tggacaagct     1380

gctgcactgt ctcagttctg cttgaatacc tccatcgatg gggaactcac ttcctttgga     1440

aaaattctta tgtcaagctg aaattctcta attttttctc atcacttccc caggagcagc     1500

cagaagacag gcagtagttt taatttcagg aacaggtgat ccactctgta aaacagcagg     1560

taaatttcac tcaaccccat gtgggaattg atctatatct ctacttccag ggaccatttg     1620

cccttcccaa atccctccag gccagaactg actggagcag gcatggccca ccaggcttca     1680

ggagtagggg aagcctggag ccccactcca gccctgggac aacttgagaa ttccccctga     1740

ggccagttct gtcatggatg ctgtcctgag aataacttgc tgtcccggtg tcacctgctt     1800

ccatctccca gcccaccagc cctctgccca cctcacatgc ctccccatgg attggggcct     1860

cccaggcccc ccaccttatg tcaacctgca cttcttgttc aaaaatcagg aaaagaaaag     1920

atttgaagac cccaagtctt gtcaataact tgctgtgtgg aagcagcggg ggaagaccta     1980

gaaccctttc cccagcactt ggttttccaa catgatattt atgagtaatt tattttgata     2040

tgtacatctc ttattttctt acattattta tgcccccaaa ttatatttat gtatgtaagt     2100

gaggtttgtt ttgtatatta aaatggagtt tgtttgtaaa aaaaaaaaaa aaaaaaa        2157


<210>  2
<211>  216
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(216)
<223>  fibroblast growth factor 19 precursor

<400>  2

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  3
<211>  3115
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3115)
<223>  Homo sapiens fibroblast growth factor receptor 4 (FGFR4), 
       transcript variant 1, mRNA

<400>  3
gacaggaggt gggccgctcg cggccacgcc gccgtcgcgg gtacattcct cgctcccggc       60

cgaggagcgc tcgggctgtc tgcggaccct gccgcgtgca ggggtcgcgg ccggctggag      120

ctgggagtga ggcggcggag gagccaggtg aggaggagcc aggaaggcag ttggtgggaa      180

gtccagcttg ggtccctgag agctgtgaga aggagatgcg gctgctgctg gccctgttgg      240

gggtcctgct gagtgtgcct gggcctccag tcttgtccct ggaggcctct gaggaagtgg      300

agcttgagcc ctgcctggct cccagcctgg agcagcaaga gcaggagctg acagtagccc      360

ttgggcagcc tgtgcgtctg tgctgtgggc gggctgagcg tggtggccac tggtacaagg      420

agggcagtcg cctggcacct gctggccgtg tacggggctg gaggggccgc ctagagattg      480

ccagcttcct acctgaggat gctggccgct acctctgcct ggcacgaggc tccatgatcg      540

tcctgcagaa tctcaccttg attacaggtg actccttgac ctccagcaac gatgatgagg      600

accccaagtc ccatagggac ccctcgaata ggcacagtta cccccagcaa gcaccctact      660

ggacacaccc ccagcgcatg gagaagaaac tgcatgcagt acctgcgggg aacaccgtca      720

agttccgctg tccagctgca ggcaacccca cgcccaccat ccgctggctt aaggatggac      780

aggcctttca tggggagaac cgcattggag gcattcggct gcgccatcag cactggagtc      840

tcgtgatgga gagcgtggtg ccctcggacc gcggcacata cacctgcctg gtagagaacg      900

ctgtgggcag catccgctat aactacctgc tagatgtgct ggagcggtcc ccgcaccggc      960

ccatcctgca ggccgggctc ccggccaaca ccacagccgt ggtgggcagc gacgtggagc     1020

tgctgtgcaa ggtgtacagc gatgcccagc cccacatcca gtggctgaag cacatcgtca     1080

tcaacggcag cagcttcgga gccgacggtt tcccctatgt gcaagtccta aagactgcag     1140

acatcaatag ctcagaggtg gaggtcctgt acctgcggaa cgtgtcagcc gaggacgcag     1200

gcgagtacac ctgcctcgca ggcaattcca tcggcctctc ctaccagtct gcctggctca     1260

cggtgctgcc agaggaggac cccacatgga ccgcagcagc gcccgaggcc aggtatacgg     1320

acatcatcct gtacgcgtcg ggctccctgg ccttggctgt gctcctgctg ctggccgggc     1380

tgtatcgagg gcaggcgctc cacggccggc acccccgccc gcccgccact gtgcagaagc     1440

tctcccgctt ccctctggcc cgacagttct ccctggagtc aggctcttcc ggcaagtcaa     1500

gctcatccct ggtacgaggc gtgcgtctct cctccagcgg ccccgccttg ctcgccggcc     1560

tcgtgagtct agatctacct ctcgacccac tatgggagtt cccccgggac aggctggtgc     1620

ttgggaagcc cctaggcgag ggctgctttg gccaggtagt acgtgcagag gcctttggca     1680

tggaccctgc ccggcctgac caagccagca ctgtggccgt caagatgctc aaagacaacg     1740

cctctgacaa ggacctggcc gacctggtct cggagatgga ggtgatgaag ctgatcggcc     1800

gacacaagaa catcatcaac ctgcttggtg tctgcaccca ggaagggccc ctgtacgtga     1860

tcgtggagtg cgccgccaag ggaaacctgc gggagttcct gcgggcccgg cgccccccag     1920

gccccgacct cagccccgac ggtcctcgga gcagtgaggg gccgctctcc ttcccagtcc     1980

tggtctcctg cgcctaccag gtggcccgag gcatgcagta tctggagtcc cggaagtgta     2040

tccaccggga cctggctgcc cgcaatgtgc tggtgactga ggacaatgtg atgaagattg     2100

ctgactttgg gctggcccgc ggcgtccacc acattgacta ctataagaaa accagcaacg     2160

gccgcctgcc tgtgaagtgg atggcgcccg aggccttgtt tgaccgggtg tacacacacc     2220

agagtgacgt gtggtctttt gggatcctgc tatgggagat cttcaccctc gggggctccc     2280

cgtatcctgg catcccggtg gaggagctgt tctcgctgct gcgggaggga catcggatgg     2340

accgaccccc acactgcccc ccagagctgt acgggctgat gcgtgagtgc tggcacgcag     2400

cgccctccca gaggcctacc ttcaagcagc tggtggaggc gctggacaag gtcctgctgg     2460

ccgtctctga ggagtacctc gacctccgcc tgaccttcgg accctattcc ccctctggtg     2520

gggacgccag cagcacctgc tcctccagcg attctgtctt cagccacgac cccctgccat     2580

tgggatccag ctccttcccc ttcgggtctg gggtgcagac atgagcaagg ctcaaggctg     2640

tgcaggcaca taggctggtg gccttgggcc ttggggctca gccacagcct gacacagtgc     2700

tcgaccttga tagcatgggg cccctggccc agagttgctg tgccgtgtcc aagggccgtg     2760

cccttgccct tggagctgcc gtgcctgtgt cctgatggcc caaatgtcag ggttctgctc     2820

ggcttcttgg accttggcgc ttagtcccca tcccgggttt ggctgagcct ggctggagag     2880

ctgctatgct aaacctcctg cctcccaata ccagcaggag gttctgggcc tctgaacccc     2940

ctttccccac acctccccct gctgctgctg ccccagcgtc ttgacgggag cattggcccc     3000

tgagcccaga gaagctggaa gcctgccgaa aacaggagca aatggcgttt tataaattat     3060

ttttttgaaa taaagctctg tgtgcctggg aaaaaaaaaa aaaaaaaaaa aaaaa          3115


<210>  4
<211>  802
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(802)
<223>  fibroblast growth factor receptor 4 isoform 1 precursor

<400>  4

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  5
<211>  6079
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6079)
<223>  Homo sapiens klotho beta (KLB), mRNA

<400>  5
atcctcagtc tcccagttca agctaatcat tgacagagct ttacaatcac aagcttttac       60

tgaagctttg ataagacagt ccagcagttg gtggcaaatg aagccaggct gtgcggcagg      120

atctccaggg aatgaatgga ttttcttcag cactgatgaa ataaccacac gctataggaa      180

tacaatgtcc aacgggggat tgcaaagatc tgtcatcctg tcagcactta ttctgctacg      240

agctgttact ggattctctg gagatggaag agctatatgg tctaaaaatc ctaattttac      300

tccggtaaat gaaagtcagc tgtttctcta tgacactttc cctaaaaact ttttctgggg      360

tattgggact ggagcattgc aagtggaagg gagttggaag aaggatggaa aaggaccttc      420

tatatgggat catttcatcc acacacacct taaaaatgtc agcagcacga atggttccag      480

tgacagttat atttttctgg aaaaagactt atcagccctg gattttatag gagtttcttt      540

ttatcaattt tcaatttcct ggccaaggct tttccccgat ggaatagtaa cagttgccaa      600

cgcaaaaggt ctgcagtact acagtactct tctggacgct ctagtgctta gaaacattga      660

acctatagtt actttatacc actgggattt gcctttggca ctacaagaaa aatatggggg      720

gtggaaaaat gataccataa tagatatctt caatgactat gccacatact gtttccagat      780

gtttggggac cgtgtcaaat attggattac aattcacaac ccatatctag tggcttggca      840

tgggtatggg acaggtatgc atgcccctgg agagaaggga aatttagcag ctgtctacac      900

tgtgggacac aacttgatca aggctcactc gaaagtttgg cataactaca acacacattt      960

ccgcccacat cagaagggtt ggttatcgat cacgttggga tctcattgga tcgagccaaa     1020

ccggtcggaa aacacgatgg atatattcaa atgtcaacaa tccatggttt ctgtgcttgg     1080

atggtttgcc aaccctatcc atggggatgg cgactatcca gaggggatga gaaagaagtt     1140

gttctccgtt ctacccattt tctctgaagc agagaagcat gagatgagag gcacagctga     1200

tttctttgcc ttttcttttg gacccaacaa cttcaagccc ctaaacacca tggctaaaat     1260

gggacaaaat gtttcactta atttaagaga agcgctgaac tggattaaac tggaatacaa     1320

caaccctcga atcttgattg ctgagaatgg ctggttcaca gacagtcgtg tgaaaacaga     1380

agacaccacg gccatctaca tgatgaagaa tttcctcagc caggtgcttc aagcaataag     1440

gttagatgaa atacgagtgt ttggttatac tgcctggtct ctcctggatg gctttgaatg     1500

gcaggatgct tacaccatcc gccgaggatt attttatgtg gattttaaca gtaaacagaa     1560

agagcggaaa cctaagtctt cagcacacta ctacaaacag atcatacgag aaaatggttt     1620

ttctttaaaa gagtccacgc cagatgtgca gggccagttt ccctgtgact tctcctgggg     1680

tgtcactgaa tctgttctta agcccgagtc tgtggcttcg tccccacagt tcagcgatcc     1740

tcatctgtac gtgtggaacg ccactggcaa cagactgttg caccgagtgg aaggggtgag     1800

gctgaaaaca cgacccgctc aatgcacaga ttttgtaaac atcaaaaaac aacttgagat     1860

gttggcaaga atgaaagtca cccactaccg gtttgctctg gattgggcct cggtccttcc     1920

cactggcaac ctgtccgcgg tgaaccgaca ggccctgagg tactacaggt gcgtggtcag     1980

tgaggggctg aagcttggca tctccgcgat ggtcaccctg tattatccga cccacgccca     2040

cctaggcctc cccgagcctc tgttgcatgc cgacgggtgg ctgaacccat cgacggccga     2100

ggccttccag gcctacgctg ggctgtgctt ccaggagctg ggggacctgg tgaagctctg     2160

gatcaccatc aacgagccta accggctaag tgacatctac aaccgctctg gcaacgacac     2220

ctacggggcg gcgcacaacc tgctggtggc ccacgccctg gcctggcgcc tctacgaccg     2280

gcagttcagg ccctcacagc gcggggccgt gtcgctgtcg ctgcacgcgg actgggcgga     2340

acccgccaac ccctatgctg actcgcactg gagggcggcc gagcgcttcc tgcagttcga     2400

gatcgcctgg ttcgccgagc cgctcttcaa gaccggggac taccccgcgg ccatgaggga     2460

atacattgcc tccaagcacc gacgggggct ttccagctcg gccctgccgc gcctcaccga     2520

ggccgaaagg aggctgctca agggcacggt cgacttctgc gcgctcaacc acttcaccac     2580

taggttcgtg atgcacgagc agctggccgg cagccgctac gactcggaca gggacatcca     2640

gtttctgcag gacatcaccc gcctgagctc ccccacgcgc ctggctgtga ttccctgggg     2700

ggtgcgcaag ctgctgcggt gggtccggag gaactacggc gacatggaca tttacatcac     2760

cgccagtggc atcgacgacc aggctctgga ggatgaccgg ctccggaagt actacctagg     2820

gaagtacctt caggaggtgc tgaaagcata cctgattgat aaagtcagaa tcaaaggcta     2880

ttatgcattc aaactggctg aagagaaatc taaacccaga tttggattct tcacatctga     2940

ttttaaagct aaatcctcaa tacaatttta caacaaagtg atcagcagca ggggcttccc     3000

ttttgagaac agtagttcta gatgcagtca gacccaagaa aatacagagt gcactgtctg     3060

cttattcctt gtgcagaaga aaccactgat attcctgggt tgttgcttct tctccaccct     3120

ggttctactc ttatcaattg ccatttttca aaggcagaag agaagaaagt tttggaaagc     3180

aaaaaactta caacacatac cattaaagaa aggcaagaga gttgttagct aaactgatct     3240

gtctgcatga tagacagttt aaaaattcat cccagttcca tatgctggta acttacagga     3300

gatatacctg tattatagaa agacaatctg agatacagct gtaaccaagg tgatgacaat     3360

tgtctctgct gtgtggttca aagaacattc ccttaggtgt tgacatcagt gaactcagtt     3420

cttggatgta aacataaagg cttcatcctg acagtaagct atgaggatta catgctacat     3480

tgcttcttaa agtttcatca actgtattcc atcattctgc tttagctttc atctctacca     3540

atagctactt gtggtacaat aaattatttt taagaagtaa aactctgggg ctggacgctg     3600

tggctcacac ctgtaatctc agcactttgg gaggccgagg cggggagatc acctgaggtg     3660

aggagttcga gaccagcctg gccaacatgg tgaaaccatg tctctactaa aaatacaaaa     3720

aattagccag gcgtggtgac agtggcacct gtaatcccag ctacttggga ggctgaggca     3780

gaagtttgaa cccaggaaac aggttacagt aggccaaaat tgcgccactg cactccagcc     3840

taggcgacaa cagcaagact gtgtccaaaa aaaaaaaaaa aagcaaaagc aaaactttgt     3900

tttgttagac tctacagcag agatttaaca cccttcttta aactgggtag tcagtgatag     3960

ataatatata ttctgtcact tctaataagg tgccttctcc tttaggtcag ggtggttcta     4020

aaatggaaag aaaacacaat agggtaagta gtgcttgtct aagccagtta caacacagac     4080

tcttaaagag gatcaagccc ttcatttttc taacaacaaa aaatcaccta tagaatatct     4140

aatttgtgat cttttactag atctgatttt ttaaaataat gtaatttccg gccaggcacg     4200

gtggcaccgc ctgtaatccc agcactttgg gaggccaagg caggtggatc acctgaggtt     4260

aggagttcga gactagcctg gccaacatgg caaaacccca tctctactaa aaatacaaaa     4320

gttagccggg catggtggtg ggcacctgta atcccagcta ctcaggaggc cgaggcagga     4380

gaatcgcttg aacccgagag gcagaggttg caatgagcca agatcgtgcc attgcactcc     4440

agcctggggg acagggcaag actgtctctc aaaataaaaa aaaataataa aaataaaaat     4500

aaaagtaatt tccaaaacct catctcatgg aaagatcaca ggatgaagga aagctagact     4560

caactctgtg aatagaagtt gctatactgt aagtaaagca acaattcaga atactgaatg     4620

agtttaaatt gttttatata gcaccctttt gggctagggt taattactag atctgacttg     4680

gataatttga cactttggga aatgaactct gttcttgaga cttgttcagt gtattttaaa     4740

catctgagga agaaaactta aatatgcacc tatttatacc tattctttct ttaggtcaac     4800

atttaacacc cactgcatac attaatttgt ccttgtctgc tcactccagc aatttagacc     4860

ttaacagtca caagagacgt tcttctgtta caaagcctta gtaaattaag gcagttttga     4920

ttatattcta ggtccaccta tgtctgaagc taaattcagt atctaactgc taatgaacaa     4980

gtttccaaaa tactgtaaaa atacaattag tcaatttgag taaatgcaaa tatgatgaga     5040

aatcaatttg ctatttggcc tggcaaatgg gaacagtaaa attctgcttt actcttctct     5100

agtctccttg ccccagctgc acccactacc ccaaagttgg cagttttgag gtatgatttt     5160

caaggaattt ttttagtatt aacatctccc tctgagaact atgtacctaa ggtcacgcat     5220

acaactagtc aattctgttt ttattactct aactatgtag aaacagtaag tcacttaaaa     5280

caatcacttg gctgggtttt ttcccctttg tgccacattg attcaccctg acccaagaac     5340

tccagggaaa attctttaat gtcaactggg caactcatta acctctcttt aacatcaagg     5400

gcttgggaaa aaaaaaaaaa aggttagcca caggaataac aaaaacctgg aatttatctt     5460

tcaggttttg ctttctcttt ctcactttgt ttaaagtatc tcgtactcac agttcacaaa     5520

ttaaccttca ctgtctcttt cacattaaga gcttatgctt aaagcatgcc ccccttttct     5580

aacttgctgg tttaccataa actcccctaa gtaataaaat tcctaaccca gtactgagag     5640

tcctccttct ctgccacttg ggcattattt tactagtttt taagccatca tcgcacaaga     5700

atccaaaaac ccttaaattt tttaaccact ggcaaatatg tacagcaaat taggttaagc     5760

atttaatctg gctcatgctc tatcatacta aatattcagg tttatcataa actccttaaa     5820

aaccatcaaa ggtcaaccag aaactgataa ctcttgaaag gagcaaacag gtaagatctt     5880

tggagtttaa gcttttctga gatgtgttgt gaaaaatcta acgtgtttat cgtatattca     5940

atgtaacaac ctggagaatc acaactatat ttaaagagcc tctggaaaat gaggccagta     6000

cagtgtgact acatgtttaa ttttcaatgt aatttattcc aaataaactg gttcatgctg     6060

accacttgta ttcaactaa                                                  6079


<210>  6
<211>  1044
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1044)
<223>  beta-klotho

<400>  6

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Cys Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Cys Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  7
<211>  1660
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1660)
<223>  Homo sapiens insulin-like growth factor binding protein 1 
       (IGFBP1), mRNA

<400>  7
ggtgcactag caaaacaaac ttattttgaa cactcagctc ctagcgtgcg gcgctgccaa       60

tcattaacct cctggtgcaa gtggcgcggc ctgtgccctt tataaggtgc gcgctgtgtc      120

cagcgagcat cggccaccgc catcccatcc agcgagcatc tgccgccgcg ccgccgccac      180

cctcccagag agcactggcc accgctccac catcacttgc ccagagtttg ggccaccgcc      240

cgccgccacc agcccagaga gcatcggccc ctgtctgctg ctcgcgcctg gagatgtcag      300

aggtccccgt tgctcgcgtc tggctggtac tgctcctgct gactgtccag gtcggcgtga      360

cagccggcgc tccgtggcag tgcgcgccct gctccgccga gaagctcgcg ctctgcccgc      420

cggtgtccgc ctcgtgctcg gaggtcaccc ggtccgccgg ctgcggctgt tgcccgatgt      480

gcgccctgcc tctgggcgcc gcgtgcggcg tggcgactgc acgctgcgcc cggggactca      540

gttgccgcgc gctgccgggg gagcagcaac ctctgcacgc cctcacccgc ggccaaggcg      600

cctgcgtgca ggagtctgac gcctccgctc cccatgctgc agaggcaggg agccctgaaa      660

gcccagagag cacggagata actgaggagg agctcctgga taatttccat ctgatggccc      720

cttctgaaga ggatcattcc atcctttggg acgccatcag tacctatgat ggctcgaagg      780

ctctccatgt caccaacatc aaaaaatgga aggagccctg ccgaatagaa ctctacagag      840

tcgtagagag tttagccaag gcacaggaga catcaggaga agaaatttcc aaattttacc      900

tgccaaactg caacaagaat ggattttatc acagcagaca gtgtgagaca tccatggatg      960

gagaggcggg actctgctgg tgcgtctacc cttggaatgg gaagaggatc cctgggtctc     1020

cagagatcag gggagacccc aactgccaga tatattttaa tgtacaaaac tgaaaccaga     1080

tgaaataatg ttctgtcacg tgaaatattt aagtatatag tatatttata ctctagaaca     1140

tgcacattta tatatatatg tatatgtata tatatatagt aactactttt tatactccat     1200

acataacttg atatagaaag ctgtttattt attcactgta agtttatttt ttctacacag     1260

taaaaacttg tactatgtta ataacttgtc ctatgtcaat ttgtatatca tgaaacactt     1320

ctcatcatat tgtatgtaag taattgcatt tctgctcttc caaagctcct gcgtctgttt     1380

ttaaagagca tggaaaaata ctgcctagaa aatgcaaaat gaaataagag agagtagttt     1440

ttcagctagt ttgaaggagg acggttaact tgtatattcc accattcaca tttgatgtac     1500

atgtgtaggg aaagttaaaa gtgttgatta cataatcaaa gctacctgtg gtgatgttgc     1560

cacctgttaa aatgtacact ggatatgttg ttaaacacgt gtctataatg gaaacattta     1620

caataaatat tctgcatgga aatactgtta aaaaaaaaaa                           1660


<210>  8
<211>  259
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(259)
<223>  insulin-like growth factor-binding protein 1 precursor

<400>  8

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  9
<211>  4629
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4629)
<223>  Homo sapiens adiponectin, C1Q and collagen domain containing 
       (ADIPOQ), transcript variant 1, mRNA

<400>  9
aggctgttga ggctgggcca tctcctcctc acttccattc tgactgcagt ctgtggttct       60

gattccatac cagaggagac gggatttcac catgttgtcc aggctggtct gaaactcctg      120

acatcagggc tcaggatgct gttgctggga gctgttctac tgctattagc tctgcccggt      180

catgaccagg aaaccacgac tcaagggccc ggagtcctgc ttcccctgcc caagggggcc      240

tgcacaggtt ggatggcggg catcccaggg catccgggcc ataatggggc cccaggccgt      300

gatggcagag atggcacccc tggtgagaag ggtgagaaag gagatccagg tcttattggt      360

cctaagggag acatcggtga aaccggagta cccggggctg aaggtccccg aggctttccg      420

ggaatccaag gcaggaaagg agaacctgga gaaggtgcct atgtataccg ctcagcattc      480

agtgtgggat tggagactta cgttactatc cccaacatgc ccattcgctt taccaagatc      540

ttctacaatc agcaaaacca ctatgatggc tccactggta aattccactg caacattcct      600

gggctgtact actttgccta ccacatcaca gtctatatga aggatgtgaa ggtcagcctc      660

ttcaagaagg acaaggctat gctcttcacc tatgatcagt accaggaaaa taatgtggac      720

caggcctccg gctctgtgct cctgcatctg gaggtgggcg accaagtctg gctccaggtg      780

tatggggaag gagagcgtaa tggactctat gctgataatg acaatgactc caccttcaca      840

ggctttcttc tctaccatga caccaactga tcaccactaa ctcagagcct cctccaggcc      900

aaacagcccc aaagtcaatt aaaggctttc agtacggtta ggaagttgat tattatttag      960

ttggaggcct ttagatatta ttcattcatt tactcattca tttattcatt cattcatcga     1020

gtaactttaa aaaaatcata tgctatgttc ccagtcctgg ggagcttcac aaacatgacc     1080

agataactga ctagaaagaa gtagttgaca gtgctatttt gtgcccactg tctctcctga     1140

tgctcatatc aatcctataa ggcacaggga acaagcattc tcctgttttt acagattgta     1200

tcctgaggct gagagagtta agtgaatgtc taaggtcaca cagtattaag tgacagtgct     1260

agaaatcaaa cccagagctg tggactttgt tcactagact gtgccctttt atagaggtac     1320

atgttctctt tggagtgttg gtaggtgtct gtttcccacc tcacctgaga gccattgaat     1380

ttgccttcct catgaattaa aacctccccc aagcagagct tcctcagaga aagtggttct     1440

atgatgacgt cctgtcttgg aaggactact actcaatggc ccctgcacta ctctacttcc     1500

tcttacctat gtcccttctc atgcctttcc ctccaacggg gaaagccaac tccatctcta     1560

agtgccgaac tcatccctgt tcctcaaggc cacctggcca ggagcttctc tgatgtgata     1620

tccacttttt ttttttttga gatggagtct cactctgtca cccaggctgg agtacagtga     1680

cacgacctcg gctcactgca gcctccttct cctgggtcca agcaattatt gtgcctcagc     1740

ctcccgagta gctgagactt caggtgcatt ccaccacaca tggctaattt ttgtattttt     1800

agtagaaatg gggtttcgtc atgttggcca ggctggtctc gaactcctgg cctaggtgat     1860

ccacccgcct cgacctccca aagtgctggg attacaggca tgagccacca tgcccagtcg     1920

atatctcact ttttattttg ccatggatga gagtcctggg tgtgaggaac acctcccacc     1980

aggctagagg caactgccca ggaaggactg tgcttccgtc acctctaaat cccttgcaga     2040

tccttgataa atgcctcatg aagaccaatc tcttgaatcc catatctacc cagaattaac     2100

tccattccag tctctgcatg taatcagttt tatccacaga aacattttca ttttaggaaa     2160

tccctggttt taagtatcaa tccttgttca gctggacaat atgaatcttt tccactgaag     2220

ttagggatga ctgtgatttt cagaacacgt ccagaatttt tcatcaagaa ggtagcttga     2280

gcctgaaatg caaaacccat ggaggaattc tgaagccatt gtctccttga gtaccaacag     2340

ggtcagggaa gactgggcct cctgaattta ttattgttct ttaagaatta caggttgagg     2400

tagttgatgg tggtaaacat tctctcagga gacaataact ccagtgatgt tcttcaaaga     2460

ttttagcaaa aacagagtaa atagcattct ctatcaatat ataaatttaa aaaactatct     2520

ttttgcttac agttttaaat tctgaacaat tctctcttat atgtgtattg ctaatcatta     2580

aggtattatt ttttccacat ataaagcttt gtctttttgt tgttgttgtt gtttttaaga     2640

tggagtttcc ctctgttgcc aggctagagt gcagtggcat gatctcggct tactgcaacc     2700

tttgcctccc aggttcaagc gattcttctg cctcagcctc ccgagtagct gggaccacag     2760

gtgcctacca ccatgccagg ctaatttttg tatttttagt aaagacaggg tttcaccata     2820

ttggccaggc tggtctcgaa ctcctgacct tgtgatctgc ccgcctccat ttttgttgtt     2880

attttttgag aaagatagat atgaggttta gagagggatg aagaggtgag agtaagcctt     2940

gtgttagtca gaactctgtg ttgtgaatgt cattcacaac agaaaaccca aaatattatg     3000

caaactactg taagcaagaa aaataaagga aaaatggaaa catttattcc tttgcataat     3060

agaaattacc agagttgttc tgtctttaga taaggtttga accaaagctc aaaacaatca     3120

agaccctttt ctgtatgtcc ttctgttctg ccttccgcag tgtaggcttt accctcaggt     3180

gctacacagt atagttctag ggtttccctc ccgatatcaa aaagactgtg gcctgcccag     3240

ctctcgtatc cccaagccac accatctggc taaatggaca tcatgttttc tggtgatgcc     3300

caaagaggag agaggaagct ctctttccca gatgccccag caagtgtaac cttgcatctc     3360

attgctctgg ctgagttgtg tgcctgtttc tgaccaatca ctgagtcagg aggatgaaat     3420

attcatattg acttaattgc agcttaagtt aggggtatgt agaggtattt tccctaaagc     3480

aaaattggga cactgttatc agaaatagga gagtggatga tagatgcaaa ataatacctg     3540

tccacaacaa actcttaatg ctgtgtttga gctttcatga gtttcccaga gagacatagc     3600

tggaaaattc ctattgattt tctctaaaat ttcaacaagt agctaaagtc tggctatgct     3660

cacagtctca catctggttg gggtgggctc cttacagaac acgctttcac agttacccta     3720

aactctctgg ggcagggtta ttcctttgtg gaaccagagg cacagagaga gtcaactgag     3780

gccaaaagag gcctgagaga aactgaggtc aagatttcag gattaatggt cctgtgatgc     3840

tttgaagtac aattgtggat ttgtccaatt ctctttagtt ctgtcagctt ttgcttcata     3900

tattttagcg ctctattatt agatatatac atgtttagta ttatgtctta ttggtgcatt     3960

tactctctta tcattatgta atgtccttct ttatctgtga taattttctg tgttctgaag     4020

tctactttgt ctaaaaataa catacgcact caacttcctt ttctttcttc cttcctttct     4080

ttcttccttc ctttctttct ctctctctct ctttccttcc ttccttcctc cttttctttc     4140

tctctctctc tctctctctt tttttgacag actctcgttc tgtggccctg gctggagttc     4200

agtggtgtga tcttggctca ctgctacctc taccatgagc aattctcctg cctcagcctc     4260

ccaagtagct ggaactacag gctcatgcca ctgcgcccag ctaatttttg tatttttcgt     4320

agagacgggg tttcaccaca ttcgtcaggt tggtttcaaa ctcctgactt tgtgatccac     4380

ccgcctcggc ctcccaaagt gctgggatta caggcatgag ccatcacacc tggtcaactt     4440

tcttttgatt agtgtttttg tggtatatct ttttccatca tgttacttta aatatatcta     4500

tattattgta tttaaaatgt gtttcttaca gactgcatgt agttgggtat aatttttatc     4560

cagtctaaaa atatctgtct tttaattggt gtttagacaa tttatattta ataaaattgt     4620

tgaatttaa                                                             4629


<210>  10
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(244)
<223>  adiponectin precursor

<400>  10

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  11
<211>  1294
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1294)
<223>  Homo sapiens glucagon (GCG), mRNA

<400>  11
gcatagaatg cagatgagca aagtgagtgg gagagggaag tcatttgtaa caaaaactca       60

ttatttacag atgagaaatt tatattgtca gcgtaatatc tgtgaggcta aacagagctg      120

gagagtatat aaaagcagtg cgccttggtg cagaagtaca gagcttagga cacagagcac      180

atcaaaagtt cccaaagagg gcttgctctc tcttcacctg ctctgttcta cagcacacta      240

ccagaagaca gcagaaatga aaagcattta ctttgtggct ggattatttg taatgctggt      300

acaaggcagc tggcaacgtt cccttcaaga cacagaggag aaatccagat cattctcagc      360

ttcccaggca gacccactca gtgatcctga tcagatgaac gaggacaagc gccattcaca      420

gggcacattc accagtgact acagcaagta tctggactcc aggcgtgccc aagattttgt      480

gcagtggttg atgaatacca agaggaacag gaataacatt gccaaacgtc acgatgaatt      540

tgagagacat gctgaaggga cctttaccag tgatgtaagt tcttatttgg aaggccaagc      600

tgccaaggaa ttcattgctt ggctggtgaa aggccgagga aggcgagatt tcccagaaga      660

ggtcgccatt gttgaagaac ttggccgcag acatgctgat ggttctttct ctgatgagat      720

gaacaccatt cttgataatc ttgccgccag ggactttata aactggttga ttcagaccaa      780

aatcactgac aggaaataac tatatcacta ttcaagatca tcttcacaac atcacctgct      840

agccacgtgg gatgtttgaa atgttaagtc ctgtaaattt aagaggtgta ttctgaggcc      900

acattgcttt gcatgccaat aaataaattt tcttttagtg ttgtgtagcc aaaaattaca      960

aatggaataa agttttatca aaatattgct aaaatatcag ctttaaaata tgaaagtgct     1020

agattctgtt attttcttct tattttggat gaagtacccc aacctgttta catttagcga     1080

taaaattatt tttctatgat ataatttgta aatgtaaatt attccgatct gacatatctg     1140

cattataata ataggagaat agaagaactg gtagccacag tggtgaaatt ggaaagagaa     1200

ctttcttcct gaaacctttg tcttaaaaat actcagcttt caatgtatca aagatacaat     1260

taaataaaat tttcaagctt ctttaccatt gtct                                 1294


<210>  12
<211>  180
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(180)
<223>  glucagon preproprotein

<400>  12

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  13
<211>  1333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1333)
<223>  Homo sapiens sex hormone-binding globulin (SHBG), transcript 
       variant 1, mRNA

<400>  13
accgcccaca cgcaaggctg cctgcctcta cacattctcc caagagttgt ctgagccgcc       60

gagtggacag tggctgatta tggagagcag aggcccactg gctacctcgc gcctgctgct      120

gttgctgctg ttgctactac tgcgtcacac ccgccaggga tgggccctga gacctgttct      180

ccccacccag agtgcccacg accctccggc tgtccacctc agcaatggcc caggacaaga      240

gcctatcgct gtcatgacct ttgacctcac caagatcaca aaaacctcct cctcctttga      300

ggttcgaacc tgggacccag agggagtgat tttttatggg gataccaacc ctaaggatga      360

ctggtttatg ctgggacttc gagacggcag gcctgagatc caactgcaca atcactgggc      420

ccagcttacg gtgggtgctg gaccacggct ggatgatggg agatggcacc aggtggaagt      480

caagatggag ggggactctg tgctgctgga ggtggatggg gaggaggtgc tgcgcctgag      540

acaggtctct gggcccctga ccagcaaacg ccatcccatc atgaggattg cgcttggggg      600

gctgctcttc cccgcttcca accttcggtt gccgctggtt cctgccctgg atggctgcct      660

gcgccgggat tcctggctgg acaaacaggc cgagatctca gcatctgccc ccactagcct      720

cagaagctgt gatgtagaat caaatcccgg gatatttctc cctccaggga ctcaggcaga      780

attcaatctc cgagacattc cccagcctca tgcagagccc tgggccttct ctttggacct      840

gggactcaag caggcagcag gctcaggcca cctccttgct cttgggacac cagagaaccc      900

atcttggctc agtctccacc tccaagatca aaaggtggtg ttgtcttctg ggtcggggcc      960

agggctggat ctgcccctgg tcttgggact ccctcttcag ctgaagctga gtatgtccag     1020

ggtggtcttg agccaagggt cgaagatgaa ggcccttgcc ctgcctccct taggcctggc     1080

tcccctcctt aacctctggg ccaagcctca agggcgtctc ttcctggggg ctttaccagg     1140

agaagactct tccacctctt tttgcctgaa tggcctttgg gcacaaggtc agaggctgga     1200

tgtggaccag gccctgaaca gaagccatga gatctggact cacagctgcc cccagagccc     1260

aggcaatggc actgacgctt cccattaaag ctccacctaa gaaccccctt tgaaagttaa     1320

aaaaaaaaaa aaa                                                        1333


<210>  14
<211>  402
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(402)
<223>  sex hormone-binding globulin isoform 1 precursor

<400>  14

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly 
            180                 185                 190         


Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 
        195                 200                 205             


Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 
    210                 215                 220                 


Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile 
225                 230                 235                 240 


Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu 
                245                 250                 255     


Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu 
            260                 265                 270         


Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys Val Val Leu 
        275                 280                 285             


Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val Leu Gly Leu 
    290                 295                 300                 


Pro Leu Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu Ser Gln Gly 
305                 310                 315                 320 


Ser Lys Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu 
                325                 330                 335     


Leu Asn Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu 
            340                 345                 350         


Pro Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala 
        355                 360                 365             


Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu 
    370                 375                 380                 


Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala 
385                 390                 395                 400 


Ser His 
        


<210>  15
<211>  1166
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1166)
<223>  Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA

<400>  15
gctccgggaa tttccctggc ccggccgctc cgggctttcc agtctcaacc atgcataaaa       60

agggttcgcc gatcttgggg agccacacag cccgggtcgc aggcacctcc ccgccagctc      120

tcccgcttct cgcacagctt cccgacgcgt ctgctgagcc ccatggccca cgccacgctc      180

tccgccgccc ccagcaatcc ccggctcctg cgggtggcgc tgctgctcct gctcctggtg      240

gccgccagcc ggcgcgcagc aggagcgtcc gtggtcactg aactgcgctg ccagtgcttg      300

cagacactgc agggaattca cctcaagaac atccaaagtg tgaatgtaag gtcccccgga      360

ccccactgcg cccaaaccga agtcatagcc acactcaaga atgggaagaa agcttgtctc      420

aaccccgcat cccccatggt tcagaaaatc atcgaaaaga tactgaacaa ggggagcacc      480

aactgacagg agagaagtaa gaagcttatc agcgtatcat tgacacttcc tgcagggtgg      540

tccctgccct taccagagct gaaaatgaaa aagagaacag cagctttcta gggacagctg      600

gaaaggactt aatgtgtttg actatttctt acgagggttc tacttattta tgtatttatt      660

tttgaaagct tgtattttaa tattttacat gctgttattt aaagatgtga gtgtgtttca      720

tcaaacatag ctcagtcctg attatttaat tggaatatga tgggttttaa atgtgtcatt      780

aaactaatat ttagtgggag accataatgt gtcagccacc ttgataaatg acagggtggg      840

gaactggagg gtggggggat tgaaatgcaa gcaattagtg gatcactgtt agggtaaggg      900

aatgtatgta cacatctatt ttttatactt tttttttaaa aaaagaatgt cagttgttat      960

ttattcaaat tatctcacat tatgtgttca acatttttat gctgaagttt cccttagaca     1020

ttttatgtct tgcttgtagg gcataatgcc ttgtttaatg tccattctgc agcgtttctc     1080

tttcccttgg aaaagagaat ttatcattac tgttacattt gtacaaatga catgataata     1140

aaagttttat gaaaaaaaaa aaaaaa                                          1166


<210>  16
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  C-X-C motif chemokine 3 precursor

<400>  16

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  17
<211>  1234
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1234)
<223>  Homo sapiens chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA

<400>  17
gagctccggg aatttccctg gcccgggact ccgggctttc cagccccaac catgcataaa       60

aggggttcgc cgttctcgga gagccacaga gcccgggcca caggcagctc cttgccagct      120

ctcctcctcg cacagccgct cgaaccgcct gctgagcccc atggcccgcg ccacgctctc      180

cgccgccccc agcaatcccc ggctcctgcg ggtggcgctg ctgctcctgc tcctggtggc      240

cgccagccgg cgcgcagcag gagcgcccct ggccactgaa ctgcgctgcc agtgcttgca      300

gaccctgcag ggaattcacc tcaagaacat ccaaagtgtg aaggtgaagt cccccggacc      360

ccactgcgcc caaaccgaag tcatagccac actcaagaat gggcagaaag cttgtctcaa      420

ccccgcatcg cccatggtta agaaaatcat cgaaaagatg ctgaaaaatg gcaaatccaa      480

ctgaccagaa ggaaggagga agcttattgg tggctgttcc tgaaggaggc cctgccctta      540

caggaacaga agaggaaaga gagacacagc tgcagaggcc acctggattg cgcctaatgt      600

gtttgagcat cacttaggag aagtcttcta tttatttatt tatttattta tttgtttgtt      660

ttagaagatt ctatgttaat attttatgtg taaaataagg ttatgattga atctacttgc      720

acactctccc attatattta ttgtttattt taggtcaaac ccaagttagt tcaatcctga      780

ttcatattta atttgaagat agaaggtttg cagatattct ctagtcattt gttaatattt      840

cttcgtgatg acatatcaca tgtcagccac tgtgatagag gctgaggaat ccaagaaaat      900

ggccagtgag atcaatgtga cggcagggaa atgtatgtgt gtctattttg taactgtaaa      960

gatgaatgtc agttgttatt tattgaaatg atttcacagt gtgtggtcaa catttctcat     1020

gttgaagctt taagaactaa aatgttctaa atatcccttg gacattttat gtctttcttg     1080

taaggcatac tgccttgttt aatgttaatt atgcagtgtt tccctctgtg ttagagcaga     1140

gaggtttcga tatttattga tgttttcaca aagaacagga aaataaaata tttaaaaata     1200

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1234


<210>  18
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  C-X-C motif chemokine 2 precursor

<400>  18

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  19
<211>  994
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(994)
<223>  Homo sapiens tumor necrosis factor receptor superfamily, member 
       17 (TNFRSF17), Mrna

<400>  19
aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag       60

acacagacag cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct      120

agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc      180

tgttctttct gtagctccct tgttttcttt ttgtgatcat gttgcagatg gctgggcagt      240

gctcccaaaa tgaatatttt gacagtttgt tgcatgcttg cataccttgt caacttcgat      300

gttcttctaa tactcctcct ctaacatgtc agcgttattg taatgcaagt gtgaccaatt      360

cagtgaaagg aacgaatgcg attctctgga cctgtttggg actgagctta ataatttctt      420

tggcagtttt cgtgctaatg tttttgctaa ggaagataaa ctctgaacca ttaaaggacg      480

agtttaaaaa cacaggatca ggtctcctgg gcatggctaa cattgacctg gaaaagagca      540

ggactggtga tgaaattatt cttccgagag gcctcgagta cacggtggaa gaatgcacct      600

gtgaagactg catcaagagc aaaccgaagg tcgactctga ccattgcttt ccactcccag      660

ctatggagga aggcgcaacc attcttgtca ccacgaaaac gaatgactat tgcaagagcc      720

tgccagctgc tttgagtgct acggagatag agaaatcaat ttctgctagg taattaacca      780

tttcgactcg agcagtgcca ctttaaaaat cttttgtcag aatagatgat gtgtcagatc      840

tctttaggat gactgtattt ttcagttgcc gatacagctt tttgtcctct aactgtggaa      900

actctttatg ttagatatat ttctctaggt tactgttggg agcttaatgg tagaaacttc      960

cttggtttca tgattaaact cttttttttc ctga                                  994


<210>  20
<211>  184
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(184)
<223>  tumor necrosis factor receptor superfamily member 17

<400>  20

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  21
<211>  1957
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1957)
<223>  Homo sapiens adhesion molecule, interacts with CXADR antigen 1 
       (AMICA1), transcript variant 1, Mrna

<400>  21
ctgtttgcat ctctgcaacc acttcagaag gcacgtgttt ggtttgctct gagcctaacc       60

tagagtgctc gcagcagtct ttcagttgag cttggggact gcagctgtgg ggagatttca      120

gtgcattgcc tcccctgggt gctcttcatc ttggatttga aagttgagag cagcatgttt      180

tgcccactga aactcatcct gctgccagtg ttactggatt attccttggg cctgaatgac      240

ttgaatgttt ccccgcctga gctaacagtc catgtgggtg attcagctct gatgggatgt      300

gttttccaga gcacagaaga caaatgtata ttcaagatag actggactct gtcaccagga      360

gagcacgcca aggacgaata tgtgctatac tattactcca atctcagtgt gcctattggg      420

cgcttccaga accgcgtaca cttgatgggg gacatcttat gcaatgatgg ctctctcctg      480

ctccaagatg tgcaagaggc tgaccaggga acctatatct gtgaaatccg cctcaaaggg      540

gagagccagg tgttcaagaa ggcggtggta ctgcatgtgc ttccagagga gcccaaagag      600

ctcatggtcc atgtgggtgg attgattcag atgggatgtg ttttccagag cacagaagtg      660

aaacacgtga ccaaggtaga atggatattt tcaggacggc gcgcaaagga ggagattgta      720

tttcgttact accacaaact caggatgtct gtggagtact cccagagctg gggccacttc      780

cagaatcgtg tgaacctggt gggggacatt ttccgcaatg acggttccat catgcttcaa      840

ggagtgaggg agtcagatgg aggaaactac acctgcagta tccacctagg gaacctggtg      900

ttcaagaaaa ccattgtgct gcatgtcagc ccggaagagc ctcgaacact ggtgaccccg      960

gcagccctga ggcctctggt cttgggtggt aatcagttgg tgatcattgt gggaattgtc     1020

tgtgccacaa tcctgctgct ccctgttctg atattgatcg tgaagaagac ctgtggaaat     1080

aagagttcag tgaattctac agtcttggtg aagaacacga agaagactaa tccagagata     1140

aaagaaaaac cctgccattt tgaaagatgt gaaggggaga aacacattta ctccccaata     1200

attgtacggg aggtgatcga ggaagaagaa ccaagtgaaa aatcagaggc cacctacatg     1260

accatgcacc cagtttggcc ttctctgagg tcagatcgga acaactcact tgaaaaaaag     1320

tcaggtgggg gaatgccaaa aacacagcaa gccttttgag aagaatggag agtcccttca     1380

tctcagcagc ggtggagact ctctcctgtg tgtgtcctgg gccactctac cagtgatttc     1440

agactcccgc tctcccagct gtcctcctgt ctcattgttt ggtcaataca ctgaagatgg     1500

agaatttgga gcctggcaga gagactggac agctctggag gaacaggcct gctgagggga     1560

ggggagcatg gacttggcct ctggagtggg acactggccc tgggaaccag gctgagctga     1620

gtggcctcaa accccccgtt ggatcagacc ctcctgtggg cagggttctt agtggatgag     1680

ttactgggaa gaatcagaga taaaaaccaa cccaaatcat tcctctggca cattatttct     1740

aaataagtgt tgtttgtgga aatcgtccta tttttatgcc tcggttgagg gggcaagtaa     1800

agtcctggtg aggaatttac agttagaaac ttttggaaaa actgaagttc ctggaggaaa     1860

gccaaaccgt gctaacacac tagaggctgg ttttggtcct gggaaaggtt tggggtgaat     1920

gggttggaag tagggtatga atacagtttt gggattt                              1957


<210>  22
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(394)
<223>  junctional adhesion molecule-like isoform 1 precursor

<400>  22

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  23
<211>  1054
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1054)
<223>  Homo sapiens trefoil factor 3 (intestinal) (TFF3), mRNA

<400>  23
gccaaaacag tgggggctga actgacctct cccctttggg agagaaaaac tgtctgggag       60

cttgacaaag gcatgcagga gagaacagga gcagccacag ccaggaggga gagccttccc      120

caagcaaaca atccagagca gctgtgcaaa caacggtgca taaatgaggc ctcctggacc      180

atgaagcgag tcctgagctg cgtcccggag cccacggtgg tcatggctgc cagagcgctc      240

tgcatgctgg ggctggtcct ggccttgctg tcctccagct ctgctgagga gtacgtgggc      300

ctgtctgcaa accagtgtgc cgtgccagcc aaggacaggg tggactgcgg ctacccccat      360

gtcaccccca aggagtgcaa caaccggggc tgctgctttg actccaggat ccctggagtg      420

ccttggtgtt tcaagcccct gcaggaagca gaatgcacct tctgaggcac ctccagctgc      480

ccccggccgg gggatgcgag gctcggagca cccttgcccg gctgtgattg ctgccaggca      540

ctgttcatct cagcttttct gtccctttgc tcccggcaag cgcttctgct gaaagttcat      600

atctggagcc tgatgtctta acgaataaag gtcccatgct ccacccgagg acagttcttc      660

gtgcctgaga ctttctgagg ttgtgcttta tttctgctgc gtcgtgggag agggcgggag      720

ggtgtcaggg gagagtctgc ccaggcctca agggcaggaa aagactccct aaggagctgc      780

agtgcatgca aggatatttt gaatccagac tggcacccac gtcacaggaa agcctaggaa      840

cactgtaagt gccgcttcct cgggaaagca gaaaaaatac atttcaggta gaagttttca      900

aaaatcacaa gtctttcttg gtgaagacag caagccaata aaactgtctt ccaaagtggt      960

cctttatttc acaaccactc tcgctactgt tcaatacttg tactattcct gggttttgtt     1020

tctttgtaca gtaaacatta tgaacaaaca ggca                                 1054


<210>  24
<211>  94
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(94)
<223>  trefoil factor 3 precursor

<400>  24

Met Lys Arg Val Leu Ser Cys Val Pro Glu Pro Thr Val Val Met Ala 
1               5                   10                  15      


Ala Arg Ala Leu Cys Met Leu Gly Leu Val Leu Ala Leu Leu Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Glu Tyr Val Gly Leu Ser Ala Asn Gln Cys Ala Val 
        35                  40                  45              


Pro Ala Lys Asp Arg Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys 
    50                  55                  60                  


Glu Cys Asn Asn Arg Gly Cys Cys Phe Asp Ser Arg Ile Pro Gly Val 
65                  70                  75                  80  


Pro Trp Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys Thr Phe 
                85                  90                  


<210>  25
<211>  3236
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3236)
<223>  Homo sapiens ephrin-B3 (EFNB3), Mrna

<400>  25
ggtttcctcc cttagcccgc tgccctcaat cccagcgagg ctggggctcc ggctcggcgc       60

ccccttcctc gctccctggt ccggcgcccc atgccgcccc cgcccggtcc ccggctcccc      120

cagtccccca cttaggcggg ctcacagatc ccggggtgct ggcgcgtggg ccgggggcgc      180

gtagggcgcc tgcagacggc ccctggaagg gctctggtgg ggctgagcgc tctgccgcgg      240

gggcgcgggc acagcaggaa gcaggtccgc gtgggcgctg ggggcatcag ctaccggggt      300

ggtccgggct gaagagccag gcagccaagg cagccacccc ggggggtggg cgactttggg      360

ggagttggtg ccccgccccc caggccttgg cggggtcatg gggccccccc attctgggcc      420

ggggggcgtg cgagtcgggg ccctgctgct gctgggggtt ttggggctgg tgtctgggct      480

cagcctggag cctgtctact ggaactcggc gaataagagg ttccaggcag agggtggtta      540

tgtgctgtac cctcagatcg gggaccggct agacctgctc tgcccccggg cccggcctcc      600

tggccctcac tcctctccta attatgagtt ctacaagctg tacctggtag ggggtgctca      660

gggccggcgc tgtgaggcac cccctgcccc aaacctcctt ctcacttgtg atcgcccaga      720

cctggatctc cgcttcacca tcaagttcca ggagtatagc cctaatctct ggggccacga      780

gttccgctcg caccacgatt actacatcat tgccacatcg gatgggaccc gggagggcct      840

ggagagcctg cagggaggtg tgtgcctaac cagaggcatg aaggtgcttc tccgagtggg      900

acaaagtccc cgaggagggg ctgtcccccg aaaacctgtg tctgaaatgc ccatggaaag      960

agaccgaggg gcagcccaca gcctggagcc tgggaaggag aacctgccag gtgaccccac     1020

cagcaatgca acctcccggg gtgctgaagg ccccctgccc cctcccagca tgcctgcagt     1080

ggctggggca gcaggggggc tggcgctgct cttgctgggc gtggcagggg ctgggggtgc     1140

catgtgttgg cggagacggc gggccaagcc ttcggagagt cgccaccctg gtcctggctc     1200

cttcgggagg ggagggtctc tgggcctggg gggtggaggt gggatgggac ctcgggaggc     1260

tgagcctggg gagctaggga tagctctgcg gggtggcggg gctgcagatc cccccttctg     1320

cccccactat gagaaggtga gtggtgacta tgggcatcct gtgtatatcg tgcaggatgg     1380

gcccccccag agccctccaa acatctacta caaggtatga gggctcctct cacgtggcta     1440

tcctgaatcc agcccttctt ggggtgctcc tccagtttaa ttcctggttt gagggacacc     1500

tctaacatct cggccccctg tgccccccca gccccttcac tcctcccggc tgctgtcctc     1560

gtctccactt ttaggattcc ttaggattcc cactgcccca cttcctgccc tcccgtttgg     1620

ccatgggtgc ccccctctgt ctcagtgtcc ctggatcctt tttccttggg gaggggcaca     1680

ggctcagcct cctctctgac catgacccag gcatccttgt ccccctcacc cacccagagc     1740

taggggcggg aacagcccac cttttggttg gcaccgcctt ctttctgcct ctcactggtt     1800

ttctcttctc tatctcttat tctttccctc tcttccgtct ctaggtctgt tcttcttccc     1860

tagcatcctc ctccccacat ctcctttcac cctcttggct tcttatcctg tgcctctccc     1920

atctcctggg tgggggcatc aaagcatttc tccccttagc tttcagcccc ccttctgacc     1980

tctcatacca accactcccc tcagtctgcc aaaaatgggg gccttatggg gaaggctctg     2040

acactccacc ccagctcagg ccatgggcag cagggctcca ttctctggcc tggcccaggc     2100

ctctacatac ttactccagc catttggggt ggttgggtca tgacagctac catgagaaga     2160

agtgtcccgt tttgtccagt ggccaatagc aagatatgaa ccggtcggga catgtatgga     2220

cttggtctga tgctgaatgg gccacttggg accggaagtg acttgctcca gacaagaggt     2280

gaccaggccc ggacagaaat ggcctgggaa gtagcagaag cagtgcagca ggaactggaa     2340

gtgccttcat ccaggacagg aagtagcact tctgaaacag gaagtggtct ggctggaact     2400

ccaagtggct tagtctgggg gatcaggagg tgggaggtgg atggttctta ttctgtggag     2460

aagaagggcg ggaagaactt cctttcagga ggaagctgga acttactgac tgtaagaggt     2520

tagaggtgga ccgagaagga cttttcccag tcttcagtgg cacttcccaa gatctccctt     2580

cccttgtgct ctgtgctgat tttaggacag ctaagatgac tgccatgtgc tgtggcaggc     2640

ctaatttgtc ttgttctttc ctttccatat cccagtataa tctctgttaa tcaacaggac     2700

taccccaaga acccatgtgc tctcccgagt aacccagatg gctgtcttgt tcattccatc     2760

ctacatttct gactcctttc agactcaaca cagttccctt cttagtgacc aaaatggtgg     2820

cctactggct ggtctagctg acagtggtac ttagcaaagg ccactgtttc catagtgacc     2880

agctgatacc tcttcctgcc ctctagtgtg caattgggtg ttgcctcagt ttcctcccag     2940

ctcagtttta ttagatcaaa gctgttgttg ggcaccaggt tggccacctc aatcaccagc     3000

caagatggtt gctttgtcca ccagaggtca agttcacctc tctggtgctg tagttcccag     3060

ctccttcctg atttttctaa tcgctccttc tggggaacag gaagttgata ttgccatggt     3120

ggcggggtat gccgtcacct cagtagtttt actgtaaaag ggaaatttga acaacaaaaa     3180

ccaaaaaaaa taaaaataaa aaacttcaaa agttgacaaa aaaaaaaaaa aaaaaa         3236


<210>  26
<211>  340
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(340)
<223>  ephrin-B3 precursor

<400>  26

Met Gly Pro Pro His Ser Gly Pro Gly Gly Val Arg Val Gly Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Val Leu Gly Leu Val Ser Gly Leu Ser Leu Glu Pro 
            20                  25                  30          


Val Tyr Trp Asn Ser Ala Asn Lys Arg Phe Gln Ala Glu Gly Gly Tyr 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Arg Leu Asp Leu Leu Cys Pro Arg 
    50                  55                  60                  


Ala Arg Pro Pro Gly Pro His Ser Ser Pro Asn Tyr Glu Phe Tyr Lys 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Gly Ala Gln Gly Arg Arg Cys Glu Ala Pro Pro 
                85                  90                  95      


Ala Pro Asn Leu Leu Leu Thr Cys Asp Arg Pro Asp Leu Asp Leu Arg 
            100                 105                 110         


Phe Thr Ile Lys Phe Gln Glu Tyr Ser Pro Asn Leu Trp Gly His Glu 
        115                 120                 125             


Phe Arg Ser His His Asp Tyr Tyr Ile Ile Ala Thr Ser Asp Gly Thr 
    130                 135                 140                 


Arg Glu Gly Leu Glu Ser Leu Gln Gly Gly Val Cys Leu Thr Arg Gly 
145                 150                 155                 160 


Met Lys Val Leu Leu Arg Val Gly Gln Ser Pro Arg Gly Gly Ala Val 
                165                 170                 175     


Pro Arg Lys Pro Val Ser Glu Met Pro Met Glu Arg Asp Arg Gly Ala 
            180                 185                 190         


Ala His Ser Leu Glu Pro Gly Lys Glu Asn Leu Pro Gly Asp Pro Thr 
        195                 200                 205             


Ser Asn Ala Thr Ser Arg Gly Ala Glu Gly Pro Leu Pro Pro Pro Ser 
    210                 215                 220                 


Met Pro Ala Val Ala Gly Ala Ala Gly Gly Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Gly Val Ala Gly Ala Gly Gly Ala Met Cys Trp Arg Arg Arg Arg Ala 
                245                 250                 255     


Lys Pro Ser Glu Ser Arg His Pro Gly Pro Gly Ser Phe Gly Arg Gly 
            260                 265                 270         


Gly Ser Leu Gly Leu Gly Gly Gly Gly Gly Met Gly Pro Arg Glu Ala 
        275                 280                 285             


Glu Pro Gly Glu Leu Gly Ile Ala Leu Arg Gly Gly Gly Ala Ala Asp 
    290                 295                 300                 


Pro Pro Phe Cys Pro His Tyr Glu Lys Val Ser Gly Asp Tyr Gly His 
305                 310                 315                 320 


Pro Val Tyr Ile Val Gln Asp Gly Pro Pro Gln Ser Pro Pro Asn Ile 
                325                 330                 335     


Tyr Tyr Lys Val 
            340 


<210>  27
<211>  9478
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9478)
<223>  Homo sapiens limbic system-associated membrane protein (LSAMP), 
       mRNA

<400>  27
ggaggagggg gagagaggct ctgggttgct gctgcttctg ctgctgctgc tgctgtgtgg       60

ctgtttctgt acactcactg gcaggcttgg tgccggctcc ctcgcccgcc cgcccgccag      120

cctgggaaag tgggttacag agcgaaggag ctcagctcag acactggcag aggagcatcc      180

agtcacagag agaccaaaca agaacccttt cctttggctt cctcttcagc tcttccagag      240

ggcttgctat ttgcactctc tcttttgaaa ttgtgttgct tttacttttc acccttctgc      300

ttgggtttta tgagggcttt gttaagtctt agagggaaaa gagactgagc gagggaaaga      360

gagaggcaaa gtggaaagga ccataaactg gcaaagcccg ctctgcgctc gctgtggatg      420

aaagccccgt gttggtgaag cctctcctcg cgagcagcgc gcacccctcc agagcacccc      480

gcggacccgc acctcggcgt ggccaccatg gtcaggagag ttcagccgga tcggaaacag      540

ttgccactgg tcctactgag attgctctgc cttcttccca caggactgcc tgttcgcagc      600

gtggatttta accgaggcac ggacaacatc accgtgaggc agggggacac agccatcctc      660

aggtgcgttg tagaagacaa gaactcaaag gtggcctggt tgaaccgttc tggcatcatt      720

tttgctggac atgacaagtg gtctctggac ccacgggttg agctggagaa acgccattct      780

ctggaataca gcctccgaat ccagaaggtg gatgtctatg atgagggttc ctacacttgc      840

tcagttcaga cacagcatga gcccaagacc tcccaagttt acttgatcgt acaagtccca      900

ccaaagatct ccaatatctc ctcggatgtc actgtgaatg agggcagcaa cgtgactctg      960

gtctgcatgg ccaatggccg tcctgaacct gttatcacct ggagacacct tacaccaact     1020

ggaagggaat ttgaaggaga agaagaatat ctggagatcc ttggcatcac cagggagcag     1080

tcaggcaaat atgagtgcaa agctgccaac gaggtctcct cggcggatgt caaacaagtc     1140

aaggtcactg tgaactatcc tcccactatc acagaatcca agagcaatga agccaccaca     1200

ggacgacaag cttcactcaa atgtgaggcc tcggcagtgc ctgcacctga ctttgagtgg     1260

taccgggatg acactaggat aaatagtgcc aatggccttg agattaagag cacggagggc     1320

cagtcttccc tgacggtgac caacgtcact gaggagcact acggcaacta cacctgtgtg     1380

gctgccaaca agctgggggt caccaatgcc agcctagtcc ttttcagacc tgggtcggtg     1440

agaggaataa atggatccat cagtctggcc gtaccactgt ggctgctggc agcatctctg     1500

ctctgccttc tcagcaaatg ttaatagaat aaaaatttaa aaataattta aaaaacacac     1560

aaaaatgcgt cacacagaat acagagagag agagacagag agagagagag agagagagat     1620

gggggagacc gtttatttca caactttgtg tgtttataca tgaaggggga aataagaaag     1680

tgaagaagaa aatacaacat ttaaaacaat tttacagtcc atcattaaaa atttatgtat     1740

cattcaggat ggagaaggtt ctactgggat atgtttatat ctactaagca aatgtatgct     1800

gtgtaaagac tacaccacac taaggacatc tggatgctgt aaaaataaga gaagaaccag     1860

atggatatta agccccccaa cacacacttt atccttcctt ccttcatctt ttttcatctg     1920

tggggaagaa aataaggtct tgcctttggt gtttatattt ccataacctt ttaattctat     1980

ttttcatttg agctgacttg tagccacttc agactatcaa tggaatctta tgttgagcct     2040

ttctctggct ttccttcctc cactatctct ccaactttag agatcatccc ctctccctcc     2100

agtgcgttct atctccccca cacccaccct agatactccc ttttcaccca cctttcctcc     2160

ctcacctctc ctcacctcca ccccctcccc agagcactag tcatgccgca aatgctagga     2220

agtgccattt tcattttctc cactgtgcgt gtgtgctcaa gtctttcgct ctcacgtggg     2280

tgtacatgtg tgtgagcgtg tgtgtgtctc tctctaaagc atgccaaggg aatggtccat     2340

gtgtacatag actcattgtg ctgtagatac tgtcctgcat tgtaattgtg agatgcggct     2400

gtaacaagtt gctgggggag atggcgggga aagaggcaag gagcagagtc ctccctacat     2460

ccatggctgt cacatggcat cagtgtgtat tcaaaccaag ctatgctcct tccaagggca     2520

ggaccccata ttcctcctag tcccatcatc agaaccgagt ggggagtcac tcagaatatc     2580

actgtaaatg aaagtgccta ctatcgatgg ggtaagcaaa cagcataagg aattatgacg     2640

tggacgaggt gacctaggag agaaaatttc agattttact ctcatttcat gagtctgagg     2700

gattcttata tttcctggca tttaacaggg taggccctgc tccactgtga aaatgagcag     2760

catgtgttga gtaaatcccc agaaacagga aggtctccaa gtgtcaactc ccagtgaaag     2820

aatgatgaac cacttggaga tcctaagcag ccctgtttta cctcctccct aatcttaaat     2880

aacatttgtc ccatgaattc ccctgagcag agattgtttc ctatttcaga taaaatacag     2940

tgaaagtgag caaggcagaa aaagtcaaca gatgcccagg ctcctactgt attctggaga     3000

tactgtcaga gctctaatac agagcactgg ccataatgaa aagcagttca ctccttgtgc     3060

tcctctgcag atgtttttcc cagtgttcta ggttaatgtt ttatttggtt gcctgcataa     3120

tccctgttct gtttcactga tggtgtttgc agcaccactg ttcatggtgg tccactgtta     3180

tcctatgcca gggtgctaag aattgcatga tattcatctt ccctgctcta tttaaattta     3240

catctataag agtcatcttg acattaacac tgaaatgtga tctaggtcct taaccaaaat     3300

tgctgggcaa cttgtaataa atttagacag aaattttatg agtaccacaa agcttggtgt     3360

taccacatca ccagaaggat ttcttaggaa atgtcttgcc gagagagctg gctctctgca     3420

tatagatgtc tttgtcagaa aaccaaccct tgctctcact tacacagtag taagcactga     3480

aagtggttca gttcatgaga ggacagagaa ttattttgag attatatttg aatgtaatct     3540

tgcagagcca aatatggtat gtcattaagt tggaaccttg taaatagctg ttccatgtta     3600

taaaatgaga aactttgtaa ctggaaaaaa agaaaggaaa gaaggaagga aggaaggaag     3660

gaaggcaggg agggggggac ggggaagggg gggagggagg gagggaggga gggagggagg     3720

gagggaggga ggaaggaagg aaggaaggaa ggaaggagaa aggaaaggaa ggcaggaggg     3780

agaaagatct aagtagcatt gttaatttct tcaatttctt ctaagggatt ttattgtttg     3840

ttttagaagc ttatcacagc cttctttcat gattttgcag tttagacttg atacaaggaa     3900

aaattcagct tggggatggt taagagtgtt tatagcagat tctgacatag gagagaaaac     3960

aaattctcat ccaagaaggt agctagtaaa atatagggaa ggtgagccat attcctatgc     4020

agcatcaatt tattgacaat caggtatttc tcttaacagt ttggtcttct tagttcaaga     4080

ataaagggta tcatctttaa taataagcat tccccaaaaa ttgaagaggc agtcacacac     4140

ttaagtgtgt ggctttagaa aagcgcatgc taatttaaag atatacagga agagaaaagt     4200

aggagttaag ttggatgttg ttagaagttg gatgttagta ttaccttcag gaacagatcc     4260

ccatggcatg tcacaggcct taattatata cctggctttc ttattgtctc cactttatca     4320

tgaggacaag gtcttggttt catgggagga acttctccat tgaaataaat gtctgccatg     4380

tcagcaccgt ttgttccctc agttttaata taatggacca tatattaaac ataattaaac     4440

atatatttaa atgtggtgtt tgcctgtgtc tctagcagga tcttgaaatt ttaaaaattt     4500

gcttctggtt cctgtttcag agaaaacatt gtccccagaa atttcatagg attgaaagtg     4560

ttccctaagc agtgtgaaca atggaggaaa atatagttta gagaaaagtc agggaaaggt     4620

agggccagag gactgacacc aagaaatcat tgaatctcaa cataagactt cttggaattt     4680

agttaatcat attggaataa attccttcaa gaatcttgtc ccttggtaat caaagtttga     4740

aaccccgcac tgaaaagcac caactggttg gaaataatat actgagagga gtgaaattca     4800

tcaattaatc tgagtggcta atatatttaa tatcctttgt atacaaagta aaactccacc     4860

attcgtaaaa ggaaatcctt agacccaact ttcagttaac aaaaacagaa atgactttga     4920

cccagggtgc ttcctgaaga atgagaacta tccagggctt tacaactgca gaattgtaat     4980

tatgctctgt gcaattgttg agcaaaggtt ttgccttgct ggataaaaag tcttgtttgt     5040

ttcgagacat gaaatcccca tgtcttaaaa gaactaaggc ttatagaaaa gcagatgggt     5100

tttctctcag gaaggactgc cccattgacc tttgccttct cttccaagtc agacagactt     5160

ctcgcttgcc atgggcattt ttttactaca tagtcagact actggggcta cttatagaga     5220

ccttgtaaaa gtactcgtga ttttcacgtt cttggaggac caaacaaaaa tctgtttctc     5280

ctccaaaaat ggacttacct cctttgcaca caaaagctaa actcctcagc atgaaattgt     5340

ttgagttatt actttaccaa gttgtgagct tcttgaatcc tccagagtcg cagattccat     5400

ccctgagttg gttgtggttt cactgtttct attggctatt ctccctgaat ttttcatttt     5460

gttctttgca gggctcgaat tatttgtgga aaacaataat atatatgtgt gtgtattttt     5520

tatctttata gatgctatat ttacaataat gtatgtatta taagacaaat taagaataat     5580

gttttgatct taaaaggaag aaaagtactg aatttggttg tttagaaaga aaatctatgc     5640

tcacgtagaa agacatagag ccccactttt tccgttttgt aattatttgg cgaaaagaaa     5700

tttgcttata gactatgttt aatgggatta accatgtcct catttttctt ttcatcctca     5760

tacactttta gcctgcattt agtcttggtt accaatatca ttttttaaga gaaatgtaag     5820

tacagtgcta tatcttacct acataaacta ttaatatttt gaagacaaat gtgaaacaca     5880

ccacaaaaat ggtgagataa gaaacaaaaa tgcagtttag gaagcctcct ccttgcttaa     5940

atgtttagaa tatttcttct ccaaagactg catttgcctc agtgatgtaa attttccatc     6000

atggttggca taatatctgt aaacatctca ctaaatgcaa aatggagttt acatttatgt     6060

gcatactagc agaaaagaag taaactattc tcatttgcat gtagctatgc tgttcaaatg     6120

tcgccaacca aaatttagga aagaatttgt tttcacccag catgtacatc tcacttttct     6180

cttggcaagg aagctggtgt taacgttggg tttaggttta acatttacac cagcgaaaat     6240

gtttatgaat attatggaaa acttatttta aaccttgatt tcttttgagc acatttacat     6300

gctgcgtgct gattaataaa ttaggcacca atcatgtgta aatcaatgta aatcactagt     6360

ttatgtacat aatataaact atgtaaactt catttttcat gcagtgccca actactgcta     6420

aggtttacta tgattcttaa ggaaaaaaaa atcaaataaa aataaataaa aactgaaacg     6480

tttcacagtt cagaatcgga agaattacga ctaaagctcc aaatatgagg ttgccttagc     6540

caaaggaagc agacccacag gaacagttca aggtttatat cctgctcaag tcacctcttt     6600

ggtctttcag gatctaagtg gagattgtcc caactgttgc tgtagttgtc tcacccgacc     6660

ccaaagcaag ggaaatagag ggaaaggttt taagggctat atgtctgctg tatccactcc     6720

cagctatctt ctttttactc ctttctcacc atctaagatg tcttatttaa atagctccaa     6780

ggaagtgacc taaaccttga tgagcaaaat attactcagt ttttattttc cattcaacaa     6840

aagcagtggg aaagcttgcc atctggattc taagaaattg tgcaatataa aaaatgttat     6900

atcctcgaga aatatcttgc tgagtcaccc taggaaataa ctacctttta tttatctggt     6960

agcctaatgt ttccacacat ttatcctgaa tattgcaagt gagggactga atcattttta     7020

attgggagtt atctttctca ggcatgttct cttggagtct ttttgaagtg cctgacacgt     7080

gtaacaggat gacatatata tcattcctac aatatgaaca actgttacat aaaaaattat     7140

caaggagatg atttcaggaa acaagtgaac tttctgcaaa gacttataaa aattttaggt     7200

caaattaact tcaggcttta aatgcactaa tctacctaag agaaaaaaaa agaaaaaaaa     7260

caggaaggag ttttaagggc tcatgtgcct gttgtatcaa cccccaagtg tcttcttggt     7320

actgcttcct catcatctaa gataaactga caactttaaa gtgaggtaga aggtgtattg     7380

aattgggagt caggagaatt gggttctaac cccaagttca gccacaaata aagctgtgag     7440

acattggcaa gtcatttaac tttcctgagt cttggttttc tcatcctgaa agtgagggat     7500

tcggctgacg tctctaaaat ctctttcaac tctaaccttt attctgaata agaatttaat     7560

attcacttag tgctgtgccc agcactgttt gtaaacagca gctgtttgtt atctctagtt     7620

tggtctctgt attctcatca cttctcagaa ctatcattct accgtcttca tttctaaacc     7680

caaaactgct agaatacagg gactctggac tgggtctgta aattttttct gatcaaaact     7740

ttatagcagt gtagagaagg gacacattca aattacacta aggacattga catagctggg     7800

gttgtttcct tgtttatatt ataaaaccta aatgtggaac tatattctaa taatctttca     7860

taggaaggaa aatagccaga ctgggtatta tgcatgtaac aaatgaggac attgtgcata     7920

agaaaggaaa cattagtttt ctgtcatcct gggccaagta cctcattaca gtaaatgtgt     7980

gtctttggaa actctttgct tgtgctgatg gcggtaagca tggggtccca ggcaggttca     8040

aaggctgaac tgtaagaaat gggcaagaca atacattttg ttttggaagg aatttctcat     8100

gggataagtt tcccaaagct tgaattatag gctatgaaat aaagcaaata gatggagaga     8160

aaacaagtat tgttttcaaa aagtacaagt caattctatt taaagaagac aagctgaaaa     8220

taaaacaaaa ataaacacaa tttaggaggt tacagagttg aagacagtat gaattgttgt     8280

gaaggccaaa atcaaatgtg aaagttaggt tctctgagaa aagggtaagc agaaaggatg     8340

atttctcaag caattaataa ggaattattt tcttgtgcca tgttctagat gcattgagca     8400

cagatcctct tgtcctaagc tgtcctagag gctcaggtta gcatctatcc aaagttgtcc     8460

tttgatttta ttgtctgaaa gaacagaagg catcagagtt tccagtcact gaagagtagg     8520

gtttgttcat cacttcccag caatcacatc actttgtgta ggtaaggata tatgatgtgc     8580

ttagattact tatgaagctc tctctaagtg ggagaatgac ctgtccatgg gacaactccc     8640

cgttttcatg gtcatttcag aagtacctct ttttgggcag tgctcctgga tctacttcta     8700

cagccacatt ctactctgca caatcctccc tatgtaaagc caggcacagt acaaatatgc     8760

ttcttgcaag tgaagaaaac ccatggaagt cctagcttca tggcacgctg cagcaatccc     8820

aagctaccag gagcctcttt tgaacccact tccctaagtc tttgctcttc accagagaat     8880

ggaaattgtt catcctggtg aactgtggcc aagttctgct ccctaagtat ttacttggag     8940

tagggaggtt aaagggaaga aattcagggg gagagaagca aaagagaaca cttccaactc     9000

cctcccccat ctcccaatgc tccccacctt ccttatcact gctctactga agggtgtata     9060

aatcctgctc ttggttagaa ttctccttat taacagtgtt atatacatat aaatatatat     9120

ataaatatat tccttttttc agccctgtag acatgaactg atcttccctt gaagatacaa     9180

acacatggcc attttttgtt tgggattttt tgtttttcaa ggtttttcat ttttgtttat     9240

taggtggatt tttttccctg ggtactagct ctgtgaagga gataaaaagc gcaatgtgtg     9300

ttaaaaaaaa aaaattaaaa ttaaaatgaa aaaaagcttt ttttcttttc tttttaaatg     9360

tatttaaatt ctgtttctct cttctgttac tttacacgta tgaatgctct gctcttctgt     9420

gatcttaaaa caaaatgaaa taaacgtgaa aaggagatgt gtcttcattg acctgtca       9478


<210>  28
<211>  338
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(338)
<223>  limbic system-associated membrane protein preproprotein

<400>  28

Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: hypervariable region (HVR)-L1, sequence A1-A11

<400>  29

Lys Ala Ser Gln Asp Ile Asn Ser Phe Leu Ala 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-L2, sequence B1-B7

<400>  30

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-L2, sequence B1-B7

<400>  31

Arg Ala Asn Arg Leu Val Ser 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-L2, sequence B1-B7

<400>  32

Arg Ala Asn Arg Leu Val Glu 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-L3, sequence C1-C9

<400>  33

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-H1, sequence D1-D10

<400>  34

Gly Phe Ser Leu Thr Thr Tyr Gly Val His 
1               5                   10  


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-H2, sequence E1-E17

<400>  35

Gly Val Ile Trp Pro Gly Gly Gly Thr Asp Tyr Asn Ala Ala Phe Ile 
1               5                   10                  15      


Ser 
    


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: HVR-H3, sequence F1-F13

<400>  36

Val Arg Lys Glu Tyr Ala Asn Leu Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  37
<211>  2134
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2134)
<223>  Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA

<400>  37
gccttgaccc cacctgcctt ggccgctctg ctcccgcctc ccactgcccc tcaggccagc       60

tcaggagcca tggggcgctg ggcctgggtc cccagcccct ggcccccacc ggggctgggc      120

cccttcctcc tcctcctcct gctgctgctg ctgctgccac gggggttcca gccccagcct      180

ggcgggaacc gtacggagtc cccagaacct aatgccacag cgacccctgc gatccccact      240

atcctggtga cctctgtgac ctctgagacc ccagcaacaa gtgctccaga ggcagaggga      300

ccccaaagtg gggggctccc gcccccgccc agggcagttc cctcgagcag tagcccccag      360

gcccaagcac tcaccgagga cgggaggccc tgcaggttcc ccttccgcta cgggggccgc      420

atgctgcatg cctgcacttc ggagggcagt gcacacagga agtggtgtgc cacaactcac      480

aactacgacc gggacagggc ctggggctac tgtgtggagg ccaccccgcc tccagggggc      540

ccagctgccc tggatccctg tgcctccggc ccctgcctca atggaggctc ctgctccaat      600

acccaggacc cccagtccta tcactgcagc tgcccccggg ccttcaccgg caaggactgc      660

ggcacagaga aatgctttga tgagacccgc tacgagtacc tggagggggg cgaccgctgg      720

gcccgcgtgc gccagggcca cgtggaacag tgcgagtgct tcgggggccg gacctggtgc      780

gaaggcaccc gacatacagc ttgtctgagc agcccttgcc tgaacggggg cacctgccac      840

ctgatcgtgg ccaccgggac caccgtgtgt gcctgcccac caggcttcgc tggacggctc      900

tgcaacatcg agcctgatga gcgctgcttc ttggggaacg gcactgggta ccgtggcgtg      960

gccagcacct cagcctcggg cctcagctgc ctggcctgga actccgatct gctctaccag     1020

gagctgcacg tggactccgt gggcgccgcg gccctgctgg gcctgggccc ccatgcctac     1080

tgccggaatc cggacaatga cgagaggccc tggtgctacg tggtgaagga cagcgcgctc     1140

tcctgggagt actgccgcct ggaggcctgc gatttggaaa ctgagggcag agaatccctc     1200

accagagtcc aactgtcacc ggatctcctg gcgaccctgc ctgagccagc ctccccgggg     1260

cgccaggcct gcggcaggag gcacaagaag aggacgttcc tgcggccacg tatcatcggc     1320

ggctcctcct cgctgcccgg ctcgcacccc tggctggccg ccatctacat cggggacagc     1380

ttctgcgccg ggagcctggt ccacacctgc tgggtggtgt cggccgccca ctgcttctcc     1440

cacagccccc ccagggacag cgtctccgtg gtgctgggcc agcacttctt caaccgcacg     1500

acggacgtga cgcagacctt cggcatcgag aagtacatcc cgtacaccct gtactcggtg     1560

ttcaacccca gcgaccacga cctcgtcctg atccggctga agaagaaagg ggaccgctgt     1620

gccacacgct cgcagttcgt gcagcccatc tgcctgcccg agcccggcag caccttcccc     1680

gcaggacaca agtgccagat tgcgggctgg ggccacttgg atgagaacgt gagcggctac     1740

tccagctccc tgcgggaggc cctggtcccc ctggtcgccg accacaagtg cagcagccct     1800

gaggtctacg gcgccgacat cagccccaac atgctctgtg ccggctactt cgactgcaag     1860

tccgacgcct gccaggggga ctcagggggg cccctggcct gcgagaagaa cggcgtggct     1920

tacctctacg gcatcatcag ctggggtgac ggctgcgggc ggctccacaa gccgggggtc     1980

tacacccgcg tggccaacta tgtggactgg atcaacgacc ggatacggcc tcccaggcgg     2040

cttgtggctc cctcctgacc ctccagcggg acaccctggt tcccaccatt ccctgccttg     2100

ctgacaataa agatatttcc aagaacccgg ccca                                 2134


<210>  38
<211>  662
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(662)
<223>  hepatocyte growth factor activator isoform 1 preproprotein

<400>  38

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Asp 
        355                 360                 365             


Leu Glu Thr Glu Gly Arg Glu Ser Leu Thr Arg Val Gln Leu Ser Pro 
    370                 375                 380                 


Asp Leu Leu Ala Thr Leu Pro Glu Pro Ala Ser Pro Gly Arg Gln Ala 
385                 390                 395                 400 


Cys Gly Arg Arg His Lys Lys Arg Thr Phe Leu Arg Pro Arg Ile Ile 
                405                 410                 415     


Gly Gly Ser Ser Ser Leu Pro Gly Ser His Pro Trp Leu Ala Ala Ile 
            420                 425                 430         


Tyr Ile Gly Asp Ser Phe Cys Ala Gly Ser Leu Val His Thr Cys Trp 
        435                 440                 445             


Val Val Ser Ala Ala His Cys Phe Ser His Ser Pro Pro Arg Asp Ser 
    450                 455                 460                 


Val Ser Val Val Leu Gly Gln His Phe Phe Asn Arg Thr Thr Asp Val 
465                 470                 475                 480 


Thr Gln Thr Phe Gly Ile Glu Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser 
                485                 490                 495     


Val Phe Asn Pro Ser Asp His Asp Leu Val Leu Ile Arg Leu Lys Lys 
            500                 505                 510         


Lys Gly Asp Arg Cys Ala Thr Arg Ser Gln Phe Val Gln Pro Ile Cys 
        515                 520                 525             


Leu Pro Glu Pro Gly Ser Thr Phe Pro Ala Gly His Lys Cys Gln Ile 
    530                 535                 540                 


Ala Gly Trp Gly His Leu Asp Glu Asn Val Ser Gly Tyr Ser Ser Ser 
545                 550                 555                 560 


Leu Arg Glu Ala Leu Val Pro Leu Val Ala Asp His Lys Cys Ser Ser 
                565                 570                 575     


Pro Glu Val Tyr Gly Ala Asp Ile Ser Pro Asn Met Leu Cys Ala Gly 
            580                 585                 590         


Tyr Phe Asp Cys Lys Ser Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        595                 600                 605             


Leu Ala Cys Glu Lys Asn Gly Val Ala Tyr Leu Tyr Gly Ile Ile Ser 
    610                 615                 620                 


Trp Gly Asp Gly Cys Gly Arg Leu His Lys Pro Gly Val Tyr Thr Arg 
625                 630                 635                 640 


Val Ala Asn Tyr Val Asp Trp Ile Asn Asp Arg Ile Arg Pro Pro Arg 
                645                 650                 655     


Arg Leu Val Ala Pro Ser 
            660         


<210>  39
<211>  12086
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(12086)
<223>  Homo sapiens bone morphogenetic protein receptor, type II 
       (serine/threonine kinase) (BMPR2), mRNA

<400>  39
gactcccccc tttgtgtctg gtctgctcgg agccactgga agtgcctccc ggagggacgc       60

agggtgtctc gccgcctccc tgcccacccc cttccccggc taccttcatc cgccctcccg      120

ccgccccccg ccctcggtcc gcgacgcccg agttccgtca ggagcccaga gctgcgggag      180

aacgaggcgg cggcggcggc ggcggcggcg gcggcggcgg cagcagcagc ggcttcctcg      240

gggggttgtg attcgctcac aggagccatt gacgggagaa gaggaggctt tcttggtgga      300

atttacctca ggcaagatcg agccgcagga ataaaaagcg aggaagggaa gggagcgccg      360

ccgggaggac tagaaggggc agcctctcac acccactccg cctgccgtct cggggagccc      420

ggaccggggc cgcgaccgcg acccctcccc tcccccgctc ctacctctcc tcagccttcg      480

ccagggcctc cccaaccctc tcacggttgt tctgcgaagg cgtggggact gtgagcttgt      540

ccatggaggc aggcaccttt tttgatccag tcaaggaaga ggatttgttg ttttcgaaat      600

cagagtgaag gaagcaccga agcgaaactt aaggaatcct gccttcccgg agccgcgggc      660

gatgcgacta gggctgccgg gcgccgccgc cgcccgtccg gcttcgtcct tcccggcagt      720

cgggaactag ttctgaccct cgccccccga ccccggatcg aatccccgcc ctccgcaccc      780

tggatatgtt ttctcccaga cctggatatt tttttgatat cgtgaaacta cgagggaaat      840

aatttggggg atttcttctt ggctccctgc tttccccaca gacatgcctt ccgtttggag      900

ggccgcggca ccccgtccga ggcgaaggaa cccccccagc cgcgagggag agaaatgaag      960

ggaatttctg cagcggcatg aaagctctgc agctaggtcc tctcatcagc catttgtcct     1020

ttcaaactgt attgtgatac gggcaggatc agtccacggg agagaagacg agcctcccgg     1080

ctgtttctcc gccggtctac ttcccatatt tcttttcttt gccctcctga ttcttggctg     1140

gcccagggat gacttcctcg ctgcagcggc cctggcgggt gccctggcta ccatggacca     1200

tcctgctggt cagcactgcg gctgcttcgc agaatcaaga acggctatgt gcgtttaaag     1260

atccgtatca gcaagacctt gggataggtg agagtagaat ctctcatgaa aatgggacaa     1320

tattatgctc gaaaggtagc acctgctatg gcctttggga gaaatcaaaa ggggacataa     1380

atcttgtaaa acaaggatgt tggtctcaca ttggagatcc ccaagagtgt cactatgaag     1440

aatgtgtagt aactaccact cctccctcaa ttcagaatgg aacataccgt ttctgctgtt     1500

gtagcacaga tttatgtaat gtcaacttta ctgagaattt tccacctcct gacacaacac     1560

cactcagtcc acctcattca tttaaccgag atgagacaat aatcattgct ttggcatcag     1620

tctctgtatt agctgttttg atagttgcct tatgctttgg atacagaatg ttgacaggag     1680

accgtaaaca aggtcttcac agtatgaaca tgatggaggc agcagcatcc gaaccctctc     1740

ttgatctaga taatctgaaa ctgttggagc tgattggccg aggtcgatat ggagcagtat     1800

ataaaggctc cttggatgag cgtccagttg ctgtaaaagt gttttccttt gcaaaccgtc     1860

agaattttat caacgaaaag aacatttaca gagtgccttt gatggaacat gacaacattg     1920

cccgctttat agttggagat gagagagtca ctgcagatgg acgcatggaa tatttgcttg     1980

tgatggagta ctatcccaat ggatctttat gcaagtattt aagtctccac acaagtgact     2040

gggtaagctc ttgccgtctt gctcattctg ttactagagg actggcttat cttcacacag     2100

aattaccacg aggagatcat tataaacctg caatttccca tcgagattta aacagcagaa     2160

atgtcctagt gaaaaatgat ggaacctgtg ttattagtga ctttggactg tccatgaggc     2220

tgactggaaa tagactggtg cgcccagggg aggaagataa tgcagccata agcgaggttg     2280

gcactatcag atatatggca ccagaagtgc tagaaggagc tgtgaacttg agggactgtg     2340

aatcagcttt gaaacaagta gacatgtatg ctcttggact aatctattgg gagatattta     2400

tgagatgtac agacctcttc ccaggggaat ccgtaccaga gtaccagatg gcttttcaga     2460

cagaggttgg aaaccatccc acttttgagg atatgcaggt tctcgtgtct agggaaaaac     2520

agagacccaa gttcccagaa gcctggaaag aaaatagcct ggcagtgagg tcactcaagg     2580

agacaatcga agactgttgg gaccaggatg cagaggctcg gcttactgca cagtgtgctg     2640

aggaaaggat ggctgaactt atgatgattt gggaaagaaa caaatctgtg agcccaacag     2700

tcaatccaat gtctactgct atgcagaatg aacgcaacct gtcacataat aggcgtgtgc     2760

caaaaattgg tccttatcca gattattctt cctcctcata cattgaagac tctatccatc     2820

atactgacag catcgtgaag aatatttcct ctgagcattc tatgtccagc acacctttga     2880

ctatagggga aaaaaaccga aattcaatta actatgaacg acagcaagca caagctcgaa     2940

tccccagccc tgaaacaagt gtcaccagcc tctccaccaa cacaacaacc acaaacacca     3000

caggactcac gccaagtact ggcatgacta ctatatctga gatgccatac ccagatgaaa     3060

caaatctgca taccacaaat gttgcacagt caattgggcc aacccctgtc tgcttacagc     3120

tgacagaaga agacttggaa accaacaagc tagacccaaa agaagttgat aagaacctca     3180

aggaaagctc tgatgagaat ctcatggagc actctcttaa acagttcagt ggcccagacc     3240

cactgagcag tactagttct agcttgcttt acccactcat aaaacttgca gtagaagcaa     3300

ctggacagca ggacttcaca cagactgcaa atggccaagc atgtttgatt cctgatgttc     3360

tgcctactca gatctatcct ctccccaagc agcagaacct tcccaagaga cctactagtt     3420

tgcctttgaa caccaaaaat tcaacaaaag agccccggct aaaatttggc agcaagcaca     3480

aatcaaactt gaaacaagtc gaaactggag ttgccaagat gaatacaatc aatgcagcag     3540

aacctcatgt ggtgacagtc accatgaatg gtgtggcagg tagaaaccac agtgttaact     3600

cccatgctgc cacaacccaa tatgccaatg ggacagtact atctggccaa acaaccaaca     3660

tagtgacaca tagggcccaa gaaatgttgc agaatcagtt tattggtgag gacacccggc     3720

tgaatattaa ttccagtcct gatgagcatg agcctttact gagacgagag caacaagctg     3780

gccatgatga aggtgttctg gatcgtcttg tggacaggag ggaacggcca ctagaaggtg     3840

gccgaactaa ttccaataac aacaacagca atccatgttc agaacaagat gttcttgcac     3900

agggtgttcc aagcacagca gcagatcctg ggccatcaaa gcccagaaga gcacagaggc     3960

ctaattctct ggatctttca gccacaaatg tcctggatgg cagcagtata cagataggtg     4020

agtcaacaca agatggcaaa tcaggatcag gtgaaaagat caagaaacgt gtgaaaactc     4080

cctattctct taagcggtgg cgcccctcca cctgggtcat ctccactgaa tcgctggact     4140

gtgaagtcaa caataatggc agtaacaggg cagttcattc caaatccagc actgctgttt     4200

accttgcaga aggaggcact gctacaacca tggtgtctaa agatatagga atgaactgtc     4260

tgtgaaatgt tttcaagcct atggagtgaa attatttttt gcatcattta aacatgcaga     4320

agatgtttaa aaataaaaaa aaaactgctt tatcctcctg tcagcacccc ctcccacccc     4380

tgcaacaaag acttgcttta aatagatttc agctatgcag aaaaatttag cttatgcttc     4440

catattttta aattttgttt tttaagtttt gcacttttgt ttagtctcgc taaagttata     4500

tttgtctgtt atgaccacag agttatatgt gtgtgtatca aaagtggtct caaaatattt     4560

ttttaagaaa aaaagcaaaa acaatgtatt gctgataatc agtttggacc agtttcttaa     4620

ggtcattaaa acagaagcaa attaagacag gtttgactgc agtggtgtct ggtatccatg     4680

ttttatttct gggcacaagc tagtttttat gttgatacgt tcctgaacat attatcttgt     4740

tggacatctt ttctcttgtg ttttgtttga atgtgcaata gtttataggc cacaaataag     4800

ctttcttgta agctctcttc ctaacagggc acatattctt ccataatata aacacttttc     4860

tgccccatct cccatacttt tgaaggtcag ttctatgaca gtgaattttg cacaggagaa     4920

gcagctacct gatttcttac tttctctctc cttatcatgg agaatacaga aacattgtct     4980

gaaagggctc taaagaagga actaccaaaa cctgacttga aatgccattt cttttaacct     5040

tccaaatcct aaatgtttcc ttcaaggcat cttaataaac ttatttgctt ctggttttgg     5100

gagttcataa gagagaatag aacaaaatac aggacatcaa atattagcca tttcccattt     5160

tattttattt ttctatgtag gttcatgttc catgttcatt tatttaagaa atacattttt     5220

attggtaagc ttatagagct acacttatgg aatttttaag taggtaaata aatggttaag     5280

acaaaatagt gttatagcct tcattctctg aataggccat ctttgactca taaaattacc     5340

cttactgttt attataactt cagaagtaat ttatagttct gaacctatag tatcttttac     5400

cctgttccca agcaaagact ggtgacttta tctgaaaatg attcctcttc ccatgaccta     5460

aaacactgtg aggaaaaatc attcaagtgg catgccaagt ccctatgaag gaagggctgc     5520

tatcaaacct accttttttg agcaaactga gactaaactt ctctcttttc aaaattgtgt     5580

tatcttcctt aatcctattt tcataatttt tccttttgcc agtttttcac attatctttg     5640

atatgtgagc aacatttatt atttacatta gagtatacct tttagtaata aaatgacttg     5700

aaatcatatt atttttaaaa gccctttgct tctttcatta cttataatct cctctaaaac     5760

aacctctgca tgtttttttt aaataaagca ctttctgtca aataatggac ttttttctaa     5820

acagaaatta ttttctatta atttgcaaac tgatgatttc actttttttt actttttttt     5880

cgattatcag agtacttagt aaatgttata tagtttagtt ctaagatagt tccagggatt     5940

aaaaggttaa gaggaaaaca caaatcacca aatttctgat ttatgttttt atctcctgaa     6000

caatattttc tcactcatat tcctctatct tatcacttag ctaaagacag cctaaatttc     6060

ccaattttct gtccaaaata tttgtgattt acttgtatat aagccttctc atttgccatg     6120

tgctgtgatc ttacaagtta gatgttacta tacctaccat ttattcagct ggattgctga     6180

acacagttct ggattcatag aattaagaat atcttgttag tgcccaggat ttccacgttt     6240

tgtgttttat tggccctttt ctttattcag ccccttaatc tattttcagt cttctggcac     6300

gtaatttttt tcacagttat tattcttcta ttaacaaatt atttttatct ttcctagtac     6360

attttcactt agttctcttg cccttaaata tctttcacat gcattttagg atattctttt     6420

caaatatttg taggacaact ttgaatcaaa ataaattatg ttccttctcc aatttgaagc     6480

attgaggata aatgaccatt tgaggtctaa ctgatctttt cctgccagaa gagttatctt     6540

acgttctgct atatttgtat ttgggccagt tgattgtagg ttgtccaaca ttttttaata     6600

ttgggaaaat tatgataaaa tgctttaaaa attaatatgc cagattaaaa taactgaata     6660

gtttactatt tcattcaagc atgtttaaaa caaataattt cctttcacca gtttttctta     6720

gtaaactcct gaaaaagtag gaaaggtgga aagtatatat catttttata aattttaaat     6780

tgtacatcag acttttaaaa tctgtaatat acaagcaagc aaaattattt taaatgactt     6840

aattgtatgc taatactcat ctgataataa atgcttctta aagttgacat ttaactgcta     6900

tcacaaagtt ttatatgtag aaaagtgggg tccttttgaa taaaagatca ttcaactaaa     6960

aatattaaaa tttatttcac tggatggtaa tgtaacctta aaagcatcat aataggtaaa     7020

gtctaatatt agttccctta acaaaatcct aactgtatac cagaattagg tcactgaaag     7080

aacttgattt gaattacgtt tagacaaaaa tgatttaatt gtaaattctt aaaactttct     7140

aaatgcataa ttggcaaaaa aaaaaaccca ctgttaccag tgtaggaagt tacaagaagg     7200

cacatactga atgctgaagt atacatatgc tatttctctt aaacctcaga gcaaccatat     7260

gagcattgta attaatattc ccattttaca gatgaggaaa ctgaagctaa gagaagctaa     7320

gtaatatgcc caaggtccac atctagtaac agacaaagct gggatttcag tctatgtctg     7380

cctctctcca catctctttc atccatacca cactgcctac atgccatatg acaggatgtg     7440

taatgggcta acgtttattt aaaaagttca ggccaggtgc agtggcttat gcctataatc     7500

cccgcacttt gggaggccga gccgggtgga tcatgaggtc agacgttcaa caccagcctg     7560

gccaagatgg tgaaaccccg tctctattaa aaatattttt taaaaattaa ctgagcgtgg     7620

tggtgggcgc ctgtagtccc agctactcag gaggctaagg caggagaatc tcttgaaccc     7680

gagaggtgga ggttgcagtg agctgagatc gcgccactgc actgcagcct aggcgacaga     7740

gcaagactgc ctcaaaaaaa aaacataaaa attcagtcac tatactctgg cacaattttc     7800

atttgtatat gagccaaacc acatacctta atgatttggg aagttaggca aatatgagat     7860

atgtagacat atctatgctg attgttgctt gagaaataat tactaattct agacaaaact     7920

caatcctgta tcttccatca tgaatcttaa aatcatttca cttcactcct aacatttctt     7980

acattgcaga actaatggta aagtaaattt tacggaaaaa gttaagatag ctttgggaac     8040

agagaccttt ccctaaattg attccatagc agatttgggg gaattaacaa agaatttcag     8100

tctcatcaat cctttgaatc catcttcaaa acttctgctt ttaataactt tagaaaattt     8160

actaatctat agaactaatt gagtaggata taggaaggat acaaggatat aatgtccttt     8220

ttataaaagt ttagtatagc ttctttacat gtatccactt gttccagaaa atgtgcattg     8280

gttctgaatg tgaaaatatt taaagagaga aaggaacact caagtaagtg tgggcttcag     8340

tgggaattat cacaaaacat tggcaagtat ttttatttaa attattttca aatttgactt     8400

ctacagccaa gtggaattgg taggctgtag ctgttacact gaaatttcta gtctttgtaa     8460

gtgcctcctg aaagtcattt aaaatggaaa aatatttcaa tgagcttttc cttttttcat     8520

atttatggac atgaatattt tattggagat cattaactcc tagaatttga gattatattt     8580

ccatacaaca ttttataaag ttatgttgaa cttactacct gttatgtgca ggttattatg     8640

taactattca cagattgctt catatattgc tttatcttcc catctaactt cttaaagtta     8700

aaatccggac acacatgttg attatctaga ccagtcattc tggaaattgt aacactccca     8760

cataaacccc aggagacttt ttcagaatgc aatgtttcta aatgtactgt tactggcagt     8820

ttactctcca gcatataagg ttgcatttta acttttagat tatgaactgt gcaaacttta     8880

cccaaaacta tcttgcatga ttccctccta aatatattcc ttgattaagt aaatctggca     8940

aatcactgtt tgagctagtt acataaaatt tgttatcaag agaaggcttt tctacaagtt     9000

tccagattaa cataaagaaa agagggaatc acagggcatt taagtgcacc ttcccattac     9060

tttccttaaa tcacctcata gttaggctgg gcgcggtggc tcacgcctgt aatcccagca     9120

ctttgggagg ccgagacggt ggatcacgag gtcaggggac tgagatcatc ctggctaaca     9180

cgatgaaacc tcatctctac taaaaataca aataattagc caggcatggt ggcacgcgcc     9240

tgtagtccca gctactcggg aggcagagac aggagaatcg tttgcacccg ggaggcggag     9300

gttgttgcag tgagccgaga tcgcgccaat gcactccagc ctgggctaca gagtgagact     9360

ccatctcaaa aaaaaacaaa aaaaatcacc tcatagttta tgtctgactt actccaaacc     9420

tcagttatct gatttgtagt ctgtgtcagg aaagttttct tcatatctat tctgtctccc     9480

tcctctttga ttttaaattt ttttctttta cccagtagga caaaaaagag cagttggtca     9540

tcatccccaa tattcttagt cttcagtatg cttcaggcct ctcaatgaac acttaagtct     9600

caattcttca gacaaaattg cttaagctct tctcctcagt cctattttaa tgactttata     9660

tttaagaata tagaattata ttttctttta tattcaaatt cattactcca gttaagtaat     9720

agtttgatag tttgatagaa tcgagagtta agatgtttct atttgaaagt ggattcaacc     9780

atcagaccac cagcaaatcg gcacttaatt tttgtgttat ctaacatttt ctattgtgga     9840

attttatgat tttatattct cattagttat aactaaaaag ccatgcacac agaattgtat     9900

atcattttgc cattaaaatt ttttaacata ttgcagcaag cttagtttta tgattgagcc     9960

acaacctttt acatattttt tgtatgaaat attaaacact aaatgcaaga ttaactttca    10020

aaagcaaacc ctacattaat caggtattat ctatggacat ttttgtagac cacttttgaa    10080

atacttatta ttttgcaaca tagactggac tatacaactt tcatttaact tttaggtgac    10140

tgatttaagt tgagtgtgca tatagagaaa aacctagaaa tttatctcat ggcagataca    10200

tttgaaagta cttcagaaga atttatgctg tatattaaaa ctaggctcaa aataaatcta    10260

tcgtatcttt aaaagtccaa ttctgttatt actgtgatgt ttgtagtgtt actattaaac    10320

attgtgaaca tacacatttt taaaacaact tgaaacccat tttaaaatct gggtaagaga    10380

gaaggaatct tcagaacaaa atcacatcat tagggtgtcc agtttatgat tgaattttta    10440

agcaaattac tgtatttgaa actacaactt gatttggttt tcagttttaa aaggcaacat    10500

gtgggtttta tccattttat ttataccttt agatttcaga aacatcttca tgttttagat    10560

gcattctaca gacatcatgt tacttaaaaa ctcagggccc ctttcatccc tttgtacact    10620

gaaaaagttc aattgttagc aagtaagcaa ttagatccag ttgaatattt aaagtgtttg    10680

ttgcacagtt catttaatgt ttcatcttat ttgacttttt cacatagata taatatcaga    10740

tttcattaat tataaaaagt tgcccagttc tgtaattact gaacagaggg aatgactcaa    10800

ctaattggct acatgttgca acaaatttag gcctttagag ttgaagcact gacttaaaac    10860

gacttacatt tctgttcttt ggtcaaatga ccatacatga tatgggacaa attgtttcat    10920

tttgtttgtt ttttaataag ggaacttggt aaagtagttc ctgtcagata ggattttctc    10980

aagagacaat ttaacgttat aaagccttct aaaagtgaac taaatatttt ataactttag    11040

taatagcttg gatggttttg agaaaataac ctgtatttat cacattgtca aacagaattt    11100

ttctttgaat cagacaagtt caagctctaa attgatgtgc tatatactta aaatcctagg    11160

aagttatctg taaccagtct cttgtctcag gctcttcacc ttgttaccaa tcctcgtaag    11220

tatgtaaagg aaacatattt ttaaagaagc ttaacagtaa gaaaaaatta ctaaaagatg    11280

caattcaaag ataggtccca gtttaacact gaattgcttg acttctgtgg cttttctttt    11340

tctggccaca tttatttatt taagcaattt ttgtatgcct tgttatttca tttccataga    11400

gattatattg tatcagtgtt tatgtaagct ggaatcatcc tcagtttttt gctgataatt    11460

tttcaaataa agatacatgg ataattgtaa aatacactaa ctcttagggt gttgtagtag    11520

ctgaaacatg gagatgcgta gctgtcatgc tttttctgaa tggacaggag aaacataagc    11580

tacggagtat tcacttctga ggatgctttt ccggaaaaag aaaggctaga aaatactcgc    11640

acttcctcag aaccctcttt cttgttaacg ggtatctttt gttggtgtgt tttgctctta    11700

cattacagat agactatcat atatgacttt atgaataatt tcagttattt tgcttttgta    11760

taagctgtct gaagccttgc tatgctgtat aagttgtgtt tgatggatca gtgtgagtat    11820

aaaataaagc aaatcacttt tcttttgtat tatctatgga tgccactatg aaagctgaca    11880

ttaagccact aaagagtttt ctatgaataa gtgtaagtaa atgctttgat atatataaac    11940

ctaaataaaa agattgtatt gatacagaga cattggagaa ggagatttta aggcagttct    12000

ttaggtttaa aaaggcttgc tgtaaaatgg tgcgttattc cgtttattaa agatcatatt    12060

aatgacaata aaaaaaaaaa aaaaaa                                         12086


<210>  40
<211>  1038
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1038)
<223>  bone morphogenetic protein receptor type-2 precursor

<400>  40

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro 
                565                 570                 575     


Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu 
        595                 600                 605             


Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr 
    610                 615                 620                 


Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu 
625                 630                 635                 640 


His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser 
            820                 825                 830         


Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser 
            980                 985                 990         


Thr Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Thr  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Thr Ala  Thr Thr Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210>  41
<211>  4260
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4260)
<223>  Homo sapiens growth differentiation factor 11 (GDF11), mRNA

<400>  41
tccccgcccc ccagtcctcc ctcccctccc ctccagcatg gtgctcgcgg ccccgctgct       60

gctgggcttc ctgctcctcg ccctggagct gcggccccgg ggggaggcgg ccgagggccc      120

cgcggcggcg gcggcggcgg cggcggcggc ggcagcggcg ggggtcgggg gggagcgctc      180

cagccggcca gccccgtccg tggcgcccga gccggacggc tgccccgtgt gcgtttggcg      240

gcagcacagc cgcgagctgc gcctagagag catcaagtcg cagatcttga gcaaactgcg      300

gctcaaggag gcgcccaaca tcagccgcga ggtggtgaag cagctgctgc ccaaggcgcc      360

gccgctgcag cagatcctgg acctacacga cttccagggc gacgcgctgc agcccgagga      420

cttcctggag gaggacgagt accacgccac caccgagacc gtcattagca tggcccagga      480

gacggaccca gcagtacaga cagatggcag ccctctctgc tgccattttc acttcagccc      540

caaggtgatg ttcacaaagg tactgaaggc ccagctgtgg gtgtacctac ggcctgtacc      600

ccgcccagcc acagtctacc tgcagatctt gcgactaaaa cccctaactg gggaagggac      660

cgcaggggga gggggcggag gccggcgtca catccgtatc cgctcactga agattgagct      720

gcactcacgc tcaggccatt ggcagagcat cgacttcaag caagtgctac acagctggtt      780

ccgccagcca cagagcaact ggggcatcga gatcaacgcc tttgatccca gtggcacaga      840

cctggctgtc acctccctgg ggccgggagc cgaggggctg catccattca tggagcttcg      900

agtcctagag aacacaaaac gttcccggcg gaacctgggt ctggactgcg acgagcactc      960

aagcgagtcc cgctgctgcc gatatcccct cacagtggac tttgaggctt tcggctggga     1020

ctggatcatc gcacctaagc gctacaaggc caactactgc tccggccagt gcgagtacat     1080

gttcatgcaa aaatatccgc atacccattt ggtgcagcag gccaatccaa gaggctctgc     1140

tgggccctgt tgtaccccca ccaagatgtc cccaatcaac atgctctact tcaatgacaa     1200

gcagcagatt atctacggca agatccctgg catggtggtg gatcgctgtg gctgctctta     1260

aggtggggga tagaggatgc ctcccccaca gaccctaccc caagacccct agccctgccc     1320

ccatcccccc aagccctaga gctccctcca ctcttcccgc gaacatcaca ccgttccccg     1380

accaagccgt gtgcaataca acagagggag gcaggtggga attgagggtg aggggtttgg     1440

gggaaagggg aagcaggggc atagtcaggg tggggagtgt ttgaagtttg cagatgagaa     1500

ggtttgacaa aaagacagag agatgtagag acagtgatag agacagagga acaaaaagag     1560

cagcagtgag aaggcaaaga gagaggcaga agagacagac gaggcagaga caaaacactg     1620

agaaagagac tgaaatggag taataaatga aagccccaca ccaagcctcc tttcttccac     1680

tggcaaggtg aggggcttgg tatagtttgg ggagatcccc tgactattca gtaggagaag     1740

aaatcaaaaa tccattcttt tctccttctc tccctccaac agtggccagg ggaaggggaa     1800

gtgagggcag gggcaaaaag atttgggaat ttttatttat ttatttattg tgacttttca     1860

tttttttggt atttggcttt actggaatag gagggcccct gcccactgtg ccccgtttat     1920

cccttattcc ccaaaccctg ctctccccaa cacctactca cttaagcact tgtataaagc     1980

ctccagggtt gggaatggga gtaaagggca agagggcgga cacatgaagt ttagtttcta     2040

acccatcatc accctaactc aaccttttct gagccaaatg gcttgaattg aagccagttg     2100

tcatggaaat agtaagaggt tagggtttaa gagctgggga tgcgggggtg ggagagagaa     2160

ccctcaacat ccaggatcta tataatgaga gctactttaa accctcaggt ccaccctcat     2220

gatgctgagt tatttagcca gagggtgcag cctgcttatg cccaaattcc ctcagccaag     2280

agagagacca aagagcctct ggaatggccc tgctcccagc ctctatcttc aggtcaatta     2340

gagagagtat agagacccca gagtcccctg ggtctggaaa gcgttaggag aggtcaagaa     2400

aggagcagta aggaggctga aggttacagg gcatttgaat ccaaatcact gctctgggct     2460

agggaataga gccagcagac caaggtggga aggattctgg aagggggaca ttttagtctc     2520

ctaaccccaa agctcagggt ggaagagggg agaacaagga agcagagtgt ataattattt     2580

tttcctttta tttttggaat ctaacagtac ctggcagcag ggaggggaaa gtacagtggg     2640

gaaaagcatc tgacaaggcc agttagaaca gaggatggga aggatggaga ctcccgggct     2700

tggaaggcta ggaagcaggc agagactggt tgccatttca agtcactagc taggcccatt     2760

cattcctccc acaaccctga cccattctcc tctggactca ctgtgcctca gtttcttccc     2820

ctcaatggaa tgagaaatga cagcacccgc cacagccaag agatgaattc tgagcactta     2880

ccacgggcac tttatggaca taaaatacct ctcgctgtgg gacagataac cagggcacca     2940

gagtagtggt gaagagatgt gaggcttaag aggagtcaca ggcttcagag tacaagttcc     3000

cctctgcctc ccagctggac agtgcctaga agccaaggag ttgagaatct cctgatccac     3060

accctatcct tacttcacca ccaggcctct tggctccagg caagagctta gaggatgtca     3120

ggagaggtgg gggtaagaat cttcagcaaa actgtcactc taagtagagc cagcagttac     3180

gggtctgata aaaacagtac tgaactaaag taaagcccaa gctggtgagc aaaactggat     3240

ggctcattct tcccaagagc atgactctcc cccttggcca gttggtggaa ggggcaaagg     3300

tatgtgacca cccttgagaa ggtgatgttg gtgagcttta acatcttatt cctattctta     3360

tagtgagaaa gtgaaacaag atctttcagt agaggaatgg gcagggctgt taggctcttc     3420

agcttgcctt cacccatata gcagctatgc taaccccaag cctctctggc cctgttcttc     3480

atccttcctt ctgccccaat cctgaaggac aagacacacc cggccatcaa caccactcac     3540

atttccttgg tggaaggaaa ggaacagaga agtgaagaac agatacctcc ctccaaggtc     3600

aaatgcctcg tgatcttggc agagtaggga ttgggcaata agcatcaggt atcttccctc     3660

tacagattct agagagctgg ggcattaaat atgggggaca cttagaatac agctccttaa     3720

ataccaccaa ataaagacct ttgtgtgtgt gtggtgggtg gggggggggc aggggtcttt     3780

ctcttatgaa cataaatctg tgagctgaag tctcattccc ctgttcctcc ctacccccaa     3840

agaggcacag agtgaaggga cttggggggc acagctcagc aacccagtgg gagttagcac     3900

cccctcccac cttatgatgt gtgtggacct ggccagtgcc cctctgaaca tatcattatt     3960

agtgtaatta tcatttattt tgtgtatttg tcacattgtg tgcatgacag cctttgttaa     4020

gggtgtctga ggagtatgga gctgacaggg gcattggaat gccaggaaag aacttcttca     4080

actgagatca aggcttcctg gagggaacca ctgcaaaaag gccatcaggc agttttcaag     4140

ttatgtgaca gagggcaaag acggccatag ggtgctctga gttttgggat ggtcacatga     4200

cacaatccag cacttgaacc tgaaaaaaaa aataaaagcg gtcaaagagt ttagaattca     4260


<210>  42
<211>  407
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(407)
<223>  growth/differentiation factor 11 precursor

<400>  42

Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210>  43
<211>  1051
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1051)
<223>  Homo sapiens insulin-like growth factor binding protein 7 
       (IGFBP7), transcript variant 2, mRNA

<400>  43
actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct       60

gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc      120

ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct      180

gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga      240

gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa      300

gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg      360

cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag      420

cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac      480

ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat      540

ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc      600

tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct      660

gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt      720

aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca      780

tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt      840

acatgaaata ccagtgaaaa aaggtacaca ataaatctca cagccattta aaaatgacta      900

gtacatttgc tttaaaaaga acagaactaa gtatgaaagt atcagacgta gctattgatg      960

aaattctgta gttagcaacc cataagggca ttaagtatgc cattaaaatg tacagcatga     1020

gactccaaaa gattatctgg atgggtgact g                                    1051


<210>  44
<211>  279
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(279)
<223>  insulin-like growth factor-binding protein 7 isoform 2 precursor

<400>  44

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210>  45
<211>  980
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(980)
<223>  Homo sapiens insulin-like growth factor binding protein 6 
       (IGFBP6), mRNA

<400>  45
gcggcggcgg gcagcagctg cgctgcgact gctctggaag gagaggacgg ggcacaaacc       60

ctgaccatga ccccccacag gctgctgcca ccgctgctgc tgctgctagc tctgctgctc      120

gctgccagcc caggaggcgc cttggcgcgg tgcccaggct gcgggcaagg ggtgcaggcg      180

ggttgtccag ggggctgcgt ggaggaggag gatggggggt cgccagccga gggctgcgcg      240

gaagctgagg gctgtctcag gagggagggg caggagtgcg gggtctacac ccctaactgc      300

gccccaggac tgcagtgcca tccgcccaag gacgacgagg cgcctttgcg ggcgctgctg      360

ctcggccgag gccgctgcct tccggcccgc gcgcctgctg ttgcagagga gaatcctaag      420

gagagtaaac cccaagcagg cactgcccgc ccacaggatg tgaaccgcag agaccaacag      480

aggaatccag gcacctctac cacgccctcc cagcccaatt ctgcgggtgt ccaagacact      540

gagatgggcc catgccgtag acatctggac tcagtgctgc agcaactcca gactgaggtc      600

taccgagggg ctcaaacact ctacgtgccc aattgtgacc atcgaggctt ctaccggaag      660

cggcagtgcc gctcctccca ggggcagcgc cgaggtccct gctggtgtgt ggatcggatg      720

ggcaagtccc tgccagggtc tccagatggc aatggaagct cctcctgccc cactgggagt      780

agcggctaaa gctgggggat agaggggctg cagggccact ggaaggaaca tggagctgtc      840

atcactcaac aaaaaaccga ggccctcaat ccaccttcag gccccgcccc atgggcccct      900

caccgctggt tggaaagagt gttggtgttg gctggggtgt caataaagct gtgcttgggg      960

tcgctgaaaa aaaaaaaaaa                                                  980


<210>  46
<211>  240
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(240)
<223>  insulin-like growth factor-binding protein 6 precursor

<400>  46

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  47
<211>  1234
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1234)
<223>  Homo sapiens apolipoprotein E (APOE), transcript variant 2, mRNA

<400>  47
gggacagggg gagccctata attggacaag tctgggatcc ttgagtccta ctcagcccca       60

gcggaggtga aggacgtcct tccccaggag ccgactggcc aatcacaggc aggaagatga      120

aggttctgtg ggctgcgttg ctggtcacat tcctggcagg atgccaggcc aaggtggagc      180

aagcggtgga gacagagccg gagcccgagc tgcgccagca gaccgagtgg cagagcggcc      240

agcgctggga actggcactg ggtcgctttt gggattacct gcgctgggtg cagacactgt      300

ctgagcaggt gcaggaggag ctgctcagct cccaggtcac ccaggaactg agggcgctga      360

tggacgagac catgaaggag ttgaaggcct acaaatcgga actggaggaa caactgaccc      420

cggtggcgga ggagacgcgg gcacggctgt ccaaggagct gcaggcggcg caggcccggc      480

tgggcgcgga catggaggac gtgtgcggcc gcctggtgca gtaccgcggc gaggtgcagg      540

ccatgctcgg ccagagcacc gaggagctgc gggtgcgcct cgcctcccac ctgcgcaagc      600

tgcgtaagcg gctcctccgc gatgccgatg acctgcagaa gcgcctggca gtgtaccagg      660

ccggggcccg cgagggcgcc gagcgcggcc tcagcgccat ccgcgagcgc ctggggcccc      720

tggtggaaca gggccgcgtg cgggccgcca ctgtgggctc cctggccggc cagccgctac      780

aggagcgggc ccaggcctgg ggcgagcggc tgcgcgcgcg gatggaggag atgggcagcc      840

ggacccgcga ccgcctggac gaggtgaagg agcaggtggc ggaggtgcgc gccaagctgg      900

aggagcaggc ccagcagata cgcctgcagg ccgaggcctt ccaggcccgc ctcaagagct      960

ggttcgagcc cctggtggaa gacatgcagc gccagtgggc cgggctggtg gagaaggtgc     1020

aggctgccgt gggcaccagc gccgcccctg tgcccagcga caatcactga acgccgaagc     1080

ctgcagccat gcgaccccac gccaccccgt gcctcctgcc tccgcgcagc ctgcagcggg     1140

agaccctgtc cccgccccag ccgtcctcct ggggtggacc ctagtttaat aaagattcac     1200

caagtttcac gcatcaaaaa aaaaaaaaaa aaaa                                 1234


<210>  48
<211>  317
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(317)
<223>  apolipoprotein E isoform b precursor

<400>  48

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  49
<211>  1789
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1789)
<223>  Homo sapiens phospholipase A2, group VII (platelet-activating 
       factor acetylhydrolase, plasma) (PLA2G7), transcript variant 2, 
       mRNA

<400>  49
ggaaaaccgg cctgactggg gggtgaattc agcagggagt aaatctgatc ggcatcaggt       60

ctgcggaaag gagctggtga gcacgacacc acccaggcat tgcctggctc tctccgcggc      120

gggctaagtt aaccgcgggt ccaggagact aagctgaaac tgctgctcag ctcccaagat      180

ggtgccaccc aaattgcatg tgcttttctg cctctgcggc tgcctggctg tggtttatcc      240

ttttgactgg caatacataa atcctgttgc ccatatgaaa tcatcagcat gggtcaacaa      300

aatacaagta ctgatggctg ctgcaagctt tggccaaact aaaatccccc ggggaaatgg      360

gccttattcc gttggttgta cagacttaat gtttgatcac actaataagg gcaccttctt      420

gcgtttatat tatccatccc aagataatga tcgccttgac accctttgga tcccaaataa      480

agaatatttt tggggtctta gcaaatttct tggaacacac tggcttatgg gcaacatttt      540

gaggttactc tttggttcaa tgacaactcc tgcaaactgg aattcccctc tgaggcctgg      600

tgaaaaatat ccacttgttg ttttttctca tggtcttggg gcattcagga cactttattc      660

tgctattggc attgacctgg catctcatgg gtttatagtt gctgctgtag aacacagaga      720

tagatctgca tctgcaactt actatttcaa ggaccaatct gctgcagaaa taggggacaa      780

gtcttggctc taccttagaa ccctgaaaca agaggaggag acacatatac gaaatgagca      840

ggtacggcaa agagcaaaag aatgttccca agctctcagt ctgattcttg acattgatca      900

tggaaagcca gtgaagaatg cattagattt aaagtttgat atggaacaac tgaaggactc      960

tattgatagg gaaaaaatag cagtaattgg acattctttt ggtggagcaa cggttattca     1020

gactcttagt gaagatcaga gattcagatg tggtattgcc ctggatgcat ggatgtttcc     1080

actgggtgat gaagtatatt ccagaattcc tcagcccctc ttttttatca actctgaata     1140

tttccaatat cctgctaata tcataaaaat gaaaaaatgc tactcacctg ataaagaaag     1200

aaagatgatt acaatcaggg gttcagtcca ccagaatttt gctgacttca cttttgcaac     1260

tggcaaaata attggacaca tgctcaaatt aaagggagac atagattcaa atgtagctat     1320

tgatcttagc aacaaagctt cattagcatt cttacaaaag catttaggac ttcataaaga     1380

ttttgatcag tgggactgct tgattgaagg agatgatgag aatcttattc cagggaccaa     1440

cattaacaca accaatcaac acatcatgtt acagaactct tcaggaatag agaaatacaa     1500

ttaggattaa aataggtttt ttaaaagtct tgtttcaaaa ctgtctaaaa ttatgtgtgt     1560

gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga gagagagaga gagagagaga     1620

gaattttaat gtattttccc aaaggactca tattttaaaa tgtaggctat actgtaatcg     1680

tgattgaagc ttggactaag aattttttcc ctttagatgt aaagaaagaa tacagtatac     1740

aatattcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1789


<210>  50
<211>  441
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(441)
<223>  platelet-activating factor acetylhydrolase precursor

<400>  50

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  51
<211>  2121
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2121)
<223>  Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant
       3, mRNA

<400>  51
aacgcgggaa gcaggggcgg ggcctctggt ggcggtcggg aactcggtgg gaggcggcaa       60

cattgtttca agttggccaa attgacaaga gcgagaggta tactgcgttc catcccgacc      120

cggggccacg gtactgggcc ctgtttcccc ctcctcggcc cccgagagcc agggtccgcc      180

ttctgcaggg ttcccaggcc cccgctccag ggccgggctg acccgactcg ctggcgcttc      240

atggagaact tccaaaaggt ggaaaagatc ggagagggca cgtacggagt tgtgtacaaa      300

gccagaaaca agttgacggg agaggtggtg gcgcttaaga aaatccgcct ggacacgctg      360

ctggatgtca ttcacacaga aaataaactc tacctggttt ttgaatttct gcaccaagat      420

ctcaagaaat tcatggatgc ctctgctctc actggcattc ctcttcccct catcaagagc      480

tatctgttcc agctgctcca gggcctagct ttctgccatt ctcatcgggt cctccaccga      540

gaccttaaac ctcagaatct gcttattaac acagaggggg ccatcaagct agcagacttt      600

ggactagcca gagcttttgg agtccctgtt cgtacttaca cccatgaggt gactcgccgg      660

gccctattcc ctggagattc tgagattgac cagctcttcc ggatctttcg gactctgggg      720

accccagatg aggtggtgtg gccaggagtt acttctatgc ctgattacaa gccaagtttc      780

cccaagtggg cccggcaaga ttttagtaaa gttgtacctc ccctggatga agatggacgg      840

agcttgttat cgcaaatgct gcactacgac cctaacaagc ggatttcggc caaggcagcc      900

ctggctcacc ctttcttcca ggatgtgacc aagccagtac cccatcttcg actctgatag      960

ccttcttgaa gcccccagcc ctaatctcac cctctcctcc agtgtgggct tgaccaggct     1020

tggccttggg ctatttggac tcaggtgggc cctctgaact tgccttaaac actcaccttc     1080

tagtcttggc cagccaactc tgggaataca ggggtgaaag gggggaacca gtgaaaatga     1140

aaggaagttt cagtattaga tgcacttaag ttagcctcca ccaccctttc ccccttctct     1200

tagttattgc tgaagagggt tggtataaaa ataattttaa aaaagccttc ctacacgtta     1260

gatttgccgt accaatctct gaatgcccca taattattat ttccagtgtt tgggatgacc     1320

aggatcccaa gcctcctgct gccacaatgt ttataaaggc caaatgatag cgggggctaa     1380

gttggtgctt ttgagaacca agtaaaacaa aaccactggg aggagtctat tttaaagaat     1440

tcggttgaaa aaatagatcc aatcagttta taccctagtt agtgttttgc ctcacctaat     1500

aggctgggag actgaagact cagcccgggt ggggctgcag aaaaatgatt ggccccagtc     1560

cccttgtttg tcccttctac aggcatgagg aatctgggag gccctgagac agggattgtg     1620

cttcattcca atctattgct tcaccatggc cttatgaggc aggtgagaga tgtttgaatt     1680

tttctcttcc ttttagtatt cttagttgtt cagttgccaa ggatccctga tcccattttc     1740

ctctgacgtc cacctcctac cccataggag ttagaagtta gggtttaggc atcattttga     1800

gaatgctgac actttttcag ggctgtgatt gagtgagggc atgggtaaaa atatttcttt     1860

aaaagaagga tgaacaatta tatttatatt tcaggttata tccaatagta gagttggctt     1920

tttttttttt tttttggtca tagtgggtgg atttgttgcc atgtgcacct tggggttttg     1980

taatgacagt gctaaaaaaa aaaagcattt tttttttatg atttgtctct gtcacccttg     2040

tccttgagtg ctcttgctat taacgttatt tgtaatttag tttgtagctc attaaaaaaa     2100

tgtgcctagt tttatagttc a                                               2121


<210>  52
<211>  238
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(238)
<223>  cyclin-dependent kinase 2 isoform 3

<400>  52

Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Thr Leu Leu Asp Val Ile His Thr Glu Asn 
        35                  40                  45              


Lys Leu Tyr Leu Val Phe Glu Phe Leu His Gln Asp Leu Lys Lys Phe 
    50                  55                  60                  


Met Asp Ala Ser Ala Leu Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser 
65                  70                  75                  80  


Tyr Leu Phe Gln Leu Leu Gln Gly Leu Ala Phe Cys His Ser His Arg 
                85                  90                  95      


Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu 
            100                 105                 110         


Gly Ala Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Val 
        115                 120                 125             


Pro Val Arg Thr Tyr Thr His Glu Val Thr Arg Arg Ala Leu Phe Pro 
    130                 135                 140                 


Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly 
145                 150                 155                 160 


Thr Pro Asp Glu Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr 
                165                 170                 175     


Lys Pro Ser Phe Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val 
            180                 185                 190         


Pro Pro Leu Asp Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His 
        195                 200                 205             


Tyr Asp Pro Asn Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro 
    210                 215                 220                 


Phe Phe Gln Asp Val Thr Lys Pro Val Pro His Leu Arg Leu 
225                 230                 235             


<210>  53
<211>  2811
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2811)
<223>  Homo sapiens cyclin A2 (CCNA2), mRNA

<400>  53
ccatttcaat agtcgcggga tacttgaact gcaagaacag ccgccgctcc ggcgggctgc       60

tcgctgcatc tctgggcgtc tttggctcgc cacgctgggc agtgcctgcc tgcgcctttc      120

gcaacctcct cggccctgcg tggtctcgag ctgggtgagc gagcgggcgg gctggtaggc      180

tggcctgggc tgcgaccggc ggctacgact attctttggc cgggtcggtg cgagtggtcg      240

gctgggcaga gtgcacgctg cttggcgccg caggctgatc ccgccgtcca ctcccgggag      300

cagtgatgtt gggcaactct gcgccggggc ctgcgacccg cgaggcgggc tcggcgctgc      360

tagcattgca gcagacggcg ctccaagagg accaggagaa tatcaacccg gaaaaggcag      420

cgcccgtcca acaaccgcgg acccgggccg cgctggcggt actgaagtcc gggaacccgc      480

ggggtctagc gcagcagcag aggccgaaga cgagacgggt tgcacccctt aaggatcttc      540

ctgtaaatga tgagcatgtc accgttcctc cttggaaagc aaacagtaaa cagcctgcgt      600

tcaccattca tgtggatgaa gcagaaaaag aagctcagaa gaagccagct gaatctcaaa      660

aaatagagcg tgaagatgcc ctggctttta attcagccat tagtttacct ggacccagaa      720

aaccattggt ccctcttgat tatccaatgg atggtagttt tgagtcacca catactatgg      780

acatgtcaat tgtattagaa gatgaaaagc cagtgagtgt taatgaagta ccagactacc      840

atgaggatat tcacacatac cttagggaaa tggaggttaa atgtaaacct aaagtgggtt      900

acatgaagaa acagccagac atcactaaca gtatgagagc tatcctcgtg gactggttag      960

ttgaagtagg agaagaatat aaactacaga atgagaccct gcatttggct gtgaactaca     1020

ttgataggtt cctgtcttcc atgtcagtgc tgagaggaaa acttcagctt gtgggcactg     1080

ctgctatgct gttagcctca aagtttgaag aaatataccc cccagaagta gcagagtttg     1140

tgtacattac agatgatacc tacaccaaga aacaagttct gagaatggag catctagttt     1200

tgaaagtcct tacttttgac ttagctgctc caacagtaaa tcagtttctt acccaatact     1260

ttctgcatca gcagcctgca aactgcaaag ttgaaagttt agcaatgttt ttgggagaat     1320

taagtttgat agatgctgac ccatacctca agtatttgcc atcagttatt gctggagctg     1380

cctttcattt agcactctac acagtcacgg gacaaagctg gcctgaatca ttaatacgaa     1440

agactggata taccctggaa agtcttaagc cttgtctcat ggaccttcac cagacctacc     1500

tcaaagcacc acagcatgca caacagtcaa taagagaaaa gtacaaaaat tcaaagtatc     1560

atggtgtttc tctcctcaac ccaccagaga cactaaatct gtaacaatga aagactgcct     1620

ttgttttcta agatgtaaat cactcaaagt atatggtgta cagtttttaa cttaggtttt     1680

aattttacaa tcatttctga atacagaagt tgtggccaag tacaaattat ggtatctatt     1740

actttttaaa tggttttaat ttgtatatct tttgtatatg tatctgtctt agatatttgg     1800

ctaattttaa gtggttttgt taaagtatta atgatgccag ctgtcaggat aataaattga     1860

tttggaaaac tttgcaagtc aaatttaact tcttcaggat tttgcttagt aaagaagttt     1920

acttggttta ctatataatg ggaagtgaaa agccttcctc taaaattaaa gtaggtttag     1980

gaaaacagac cctcaaattc tgacattcat tttcctaagc aactggatca atttgctgac     2040

ttgggcataa tctaatctaa gcatatctga atacagtatt cagagataga tacagtagag     2100

attccccaga ctttttcgct ctttgtaaaa cctgtttgtt taggttttgc gaggtaaact     2160

caacagaggt tgggagtgga agagggtggg aagcttatat gcaaattaac agacgagaaa     2220

tgctccagaa ggtttattat tttaaagcac attaaaaaca aaaaactatt tttaaaatcc     2280

tgctagattt tataatggat ttgtgaataa aaaataccca gggttctcag aatggaataa     2340

atatcccttt taatagttat atatacagat atacaactgt tagctttaat tggcagctct     2400

cttctttttt cttcttttca ctggcttttt acttggtgct ttttcttgtt ttgcactggt     2460

ggtctgtgtt ctgtgaataa agcaaagtaa gaatttacta agagtatgtt aagttttgga     2520

ttattgaaat aagaggcatt tcttagtttt ccagtaggat ctaaaatgtg tcagctatga     2580

gtaagactgg catccaagaa gtttatatta tagatttagg tcctaatttt tataaatcac     2640

aaggtaaaaa aatcacagaa cagatggatc tctaatgaaa aagggatgtc tttttgttta     2700

tagtcatgtg gcaagatgag agtaaaacca gagagcaaac ctctataagt gttgagtata     2760

tgtatacatt tgaaataaac cagaaatttg ttaccttaaa aaaaaaaaaa a              2811


<210>  54
<211>  432
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(432)
<223>  cyclin-A2

<400>  54

Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 
145                 150                 155                 160 


Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 
            420                 425                 430         


<210>  55
<211>  2568
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2568)
<223>  Homo sapiens mitogen-activated protein kinase-activated protein 
       kinase 3 (MAPKAPK3), transcript variant 2, mRNA

<400>  55
acgtgggcgc cggcagcgcg actctcggcc ctgggatttc tgcggccgcc agctcccgcg       60

accgcctctc ctgcccctcg ccggtacctc agcaaggtgc gttgccgcca ggtgccacta      120

gaagcgccag gctggggccg cctctgagcg ccccgcgggg gccatggatg gtgaaacagc      180

agaggagcag gggggccctg tgcccccgcc agttgcaccc ggcggacccg gcttgggcgg      240

tgctccgggg gggcggcggg agcccaagaa gtacgcagtg accgacgact accagttgtc      300

caagcaggtg ctgggcctgg gtgtgaacgg caaagtgctg gagtgcttcc atcggcgcac      360

tggacagaag tgtgccctga agctcctgta tgacagcccc aaggcccggc aggaggtaga      420

ccatcactgg caggcttctg gcggccccca tattgtctgc atcctggatg tgtatgagaa      480

catgcaccat ggcaagcgct gtctcctcat catcatggaa tgcatggaag gtggtgagtt      540

gttcagcagg attcaggagc gtggcgacca ggctttcact gagagagaag ctgcagagat      600

aatgcgggat attggcactg ccatccagtt tctgcacagc cataacattg cccaccgaga      660

tgtcaagcct gaaaacctac tctacacatc taaggagaaa gacgcagtgc ttaagctcac      720

cgattttggc tttgctaagg agaccaccca aaatgccctg cagacaccct gctatactcc      780

ctattatgtg gcccctgagg tcctgggtcc agagaagtat gacaagtcat gtgacatgtg      840

gtccctgggt gtcatcatgt acatcctcct ttgtggcttc ccacccttct actccaacac      900

gggccaggcc atctccccgg ggatgaagag gaggattcgc ctgggccagt acggcttccc      960

caatcctgag tggtcagaag tctctgagga tgccaagcag ctgatccgcc tcctgttgaa     1020

gacagacccc acagagaggc tgaccatcac tcagttcatg aaccacccct ggatcaacca     1080

atcgatggta gtgccacaga ccccactcca cacggcccga gtgctgcagg aggacaaaga     1140

ccactgggac gaagtcaagg aggagatgac cagtgccttg gccactatgc gggtagacta     1200

cgaccaggtg aagatcaagg acctgaagac ctctaacaac cggctcctca acaagaggag     1260

aaaaaagcag gcaggcagct cctctgcctc acagggctgc aacaaccagt agctcatggg     1320

gccttggagg agcctggcct ctcagcctgc ataacagact gaaatgtgct caggccctgg     1380

ccaggagggc ccagggtcat tcttttaaca aaaggattat tttgttgtgt tttaatttgt     1440

cactcggaac ttcaggatgg aggaccctga ccctaaacct ccttcagatc tctggcccag     1500

gctcaagccc tagagatggg cagggcctag gggctgggag ctgcctgctg ccatagcagc     1560

acctttagct aggttggccc gagtgaggcc tctgtgctgt cctgccctgg tgcatggcct     1620

tagctttcta ggccactggg agttgtggct gggcttccca tcttccacag agacatctcc     1680

ctgtgggatg ggcagatggg cctggccttg agaaaggcat tggccattgg ttgccatggt     1740

gaccagggac cacgttgctg cctgtgaatg ctgagtgagc gagtaaggga ggaggggcga     1800

ttgagggttc acctctgcct tggggaggct gatttctcac acactggctg gccctctcat     1860

tctcactcct ccttgggccc tgaggctgct ggatccggtc tgcctgcctc cctgtgcagt     1920

ccagccctgc cttgctgcag ccccagccca gatggcactc agcgctctcc cctgagggag     1980

tccctgggcc tagccatccc ctcactattc ccgacccaaa gggtgacttt tcatctgaac     2040

ttaaggtggg agatattttt aacttttttc cactttggaa aatgtcactg tgacaaaagc     2100

cagcatactt tccctgcacc catctgctca ccagatctca ggcaggaaag cccctctctg     2160

ttgaagtcag gggctatctt ttggtatact tgtgtgaaag tggctggttg ggagcagagc     2220

taagtggctt cccattaacc tgaggtctct ttctttactc tgggtcagac ctgaggttgg     2280

ggaaggcgac tgagccatgc tcagaatgtc tggtcctggc ttgggcctga gtagggcaga     2340

gagggccttt cctggctgat cagagcttac cagccccacc ccaccatggt agccttaggg     2400

tgctgagtgc ctgatactgc ctgacaagtg cctgacacgc agcctagttc cttcctggcc     2460

cctctctcac tggctgggaa accctagacc atgtcagata ggacaacact gctgggtttt     2520

acatccagat agtaataaac accatttcat cattttctct tggaaaaa                  2568


<210>  56
<211>  382
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(382)
<223>  MAP kinase-activated protein kinase 3

<400>  56

Met Asp Gly Glu Thr Ala Glu Glu Gln Gly Gly Pro Val Pro Pro Pro 
1               5                   10                  15      


Val Ala Pro Gly Gly Pro Gly Leu Gly Gly Ala Pro Gly Gly Arg Arg 
            20                  25                  30          


Glu Pro Lys Lys Tyr Ala Val Thr Asp Asp Tyr Gln Leu Ser Lys Gln 
        35                  40                  45              


Val Leu Gly Leu Gly Val Asn Gly Lys Val Leu Glu Cys Phe His Arg 
    50                  55                  60                  


Arg Thr Gly Gln Lys Cys Ala Leu Lys Leu Leu Tyr Asp Ser Pro Lys 
65                  70                  75                  80  


Ala Arg Gln Glu Val Asp His His Trp Gln Ala Ser Gly Gly Pro His 
                85                  90                  95      


Ile Val Cys Ile Leu Asp Val Tyr Glu Asn Met His His Gly Lys Arg 
            100                 105                 110         


Cys Leu Leu Ile Ile Met Glu Cys Met Glu Gly Gly Glu Leu Phe Ser 
        115                 120                 125             


Arg Ile Gln Glu Arg Gly Asp Gln Ala Phe Thr Glu Arg Glu Ala Ala 
    130                 135                 140                 


Glu Ile Met Arg Asp Ile Gly Thr Ala Ile Gln Phe Leu His Ser His 
145                 150                 155                 160 


Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu Leu Tyr Thr Ser 
                165                 170                 175     


Lys Glu Lys Asp Ala Val Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys 
            180                 185                 190         


Glu Thr Thr Gln Asn Ala Leu Gln Thr Pro Cys Tyr Thr Pro Tyr Tyr 
        195                 200                 205             


Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr Asp Lys Ser Cys Asp 
    210                 215                 220                 


Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu Leu Cys Gly Phe Pro 
225                 230                 235                 240 


Pro Phe Tyr Ser Asn Thr Gly Gln Ala Ile Ser Pro Gly Met Lys Arg 
                245                 250                 255     


Arg Ile Arg Leu Gly Gln Tyr Gly Phe Pro Asn Pro Glu Trp Ser Glu 
            260                 265                 270         


Val Ser Glu Asp Ala Lys Gln Leu Ile Arg Leu Leu Leu Lys Thr Asp 
        275                 280                 285             


Pro Thr Glu Arg Leu Thr Ile Thr Gln Phe Met Asn His Pro Trp Ile 
    290                 295                 300                 


Asn Gln Ser Met Val Val Pro Gln Thr Pro Leu His Thr Ala Arg Val 
305                 310                 315                 320 


Leu Gln Glu Asp Lys Asp His Trp Asp Glu Val Lys Glu Glu Met Thr 
                325                 330                 335     


Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Asp Gln Val Lys Ile Lys 
            340                 345                 350         


Asp Leu Lys Thr Ser Asn Asn Arg Leu Leu Asn Lys Arg Arg Lys Lys 
        355                 360                 365             


Gln Ala Gly Ser Ser Ser Ala Ser Gln Gly Cys Asn Asn Gln 
    370                 375                 380         


<210>  57
<211>  1906
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1906)
<223>  Homo sapiens kallikrein-related peptidase 3 (KLK3), transcript 
       variant 3, mRNA

<400>  57
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gtgggtcatt ctgatcaccg aactgaccat gccagccctg ccgatggtcc      720

tccatggctc cctagtgccc tggagaggag gtgtctagtc agagagtagt cctggaaggt      780

ggcctctgtg aggagccacg gggacagcat cctgcagatg gtcctggccc ttgtcccacc      840

gacctgtcta caaggactgt cctcgtggac cctcccctct gcacaggagc tggaccctga      900

agtcccttcc ccaccggcca ggactggagc ccctacccct ctgttggaat ccctgcccac      960

cttcttctgg aagtcggctc tggagacatt tctctcttct tccaaagctg ggaactgcta     1020

tctgttatct gcctgtccag gtctgaaaga taggattgcc caggcagaaa ctgggactga     1080

cctatctcac tctctccctg cttttaccct tagggtgatt ctgggggccc acttgtctgt     1140

aatggtgtgc ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg     1200

ccttccctgt acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc     1260

aacccctgag cacccctatc aaccccctat tgtagtaaac ttggaacctt ggaaatgacc     1320

aggccaagac tcaagcctcc ccagttctac tgacctttgt ccttaggtgt gaggtccagg     1380

gttgctagga aaagaaatca gcagacacag gtgtagacca gagtgtttct taaatggtgt     1440

aattttgtcc tctctgtgtc ctggggaata ctggccatgc ctggagacat atcactcaat     1500

ttctctgagg acacagatag gatggggtgt ctgtgttatt tgtggggtac agagatgaaa     1560

gaggggtggg atccacactg agagagtgga gagtgacatg tgctggacac tgtccatgaa     1620

gcactgagca gaagctggag gcacaacgca ccagacactc acagcaagga tggagctgaa     1680

aacataaccc actctgtcct ggaggcactg ggaagcctag agaaggctgt gagccaagga     1740

gggagggtct tcctttggca tgggatgggg atgaagtaag gagagggact ggaccccctg     1800

gaagctgatt cactatgggg ggaggtgtat tgaagtcctc cagacaaccc tcagatttga     1860

tgatttccta gtagaactca cagaaataaa gagctgttat actgtg                    1906


<210>  58
<211>  238
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(238)
<223>  prostate-specific antigen isoform 3 preproprotein

<400>  58

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  59
<211>  3173
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3173)
<223>  Homo sapiens plasminogen activator, tissue (PLAT), transcript 
       variant 1, mRNA

<400>  59
atggccctgt ccactgagca tcctcccgcc acacagaaac ccgcccagcc ggggccaccg       60

accccacccc ctgcctggaa acttaaagga ggccggagct gtggggagct cagagctgag      120

atcctacagg agtccagggc tggagagaaa acctctgcga ggaaagggaa ggagcaagcc      180

gtgaatttaa gggacgctgt gaagcaatca tggatgcaat gaagagaggg ctctgctgtg      240

tgctgctgct gtgtggagca gtcttcgttt cgcccagcca ggaaatccat gcccgattca      300

gaagaggagc cagatcttac caagtgatct gcagagatga aaaaacgcag atgatatacc      360

agcaacatca gtcatggctg cgccctgtgc tcagaagcaa ccgggtggaa tattgctggt      420

gcaacagtgg cagggcacag tgccactcag tgcctgtcaa aagttgcagc gagccaaggt      480

gtttcaacgg gggcacctgc cagcaggccc tgtacttctc agatttcgtg tgccagtgcc      540

ccgaaggatt tgctgggaag tgctgtgaaa tagataccag ggccacgtgc tacgaggacc      600

agggcatcag ctacaggggc acgtggagca cagcggagag tggcgccgag tgcaccaact      660

ggaacagcag cgcgttggcc cagaagccct acagcgggcg gaggccagac gccatcaggc      720

tgggcctggg gaaccacaac tactgcagaa acccagatcg agactcaaag ccctggtgct      780

acgtctttaa ggcggggaag tacagctcag agttctgcag cacccctgcc tgctctgagg      840

gaaacagtga ctgctacttt gggaatgggt cagcctaccg tggcacgcac agcctcaccg      900

agtcgggtgc ctcctgcctc ccgtggaatt ccatgatcct gataggcaag gtttacacag      960

cacagaaccc cagtgcccag gcactgggcc tgggcaaaca taattactgc cggaatcctg     1020

atggggatgc caagccctgg tgccacgtgc tgaagaaccg caggctgacg tgggagtact     1080

gtgatgtgcc ctcctgctcc acctgcggcc tgagacagta cagccagcct cagtttcgca     1140

tcaaaggagg gctcttcgcc gacatcgcct cccacccctg gcaggctgcc atctttgcca     1200

agcacaggag gtcgcccgga gagcggttcc tgtgcggggg catactcatc agctcctgct     1260

ggattctctc tgccgcccac tgcttccagg agaggtttcc gccccaccac ctgacggtga     1320

tcttgggcag aacataccgg gtggtccctg gcgaggagga gcagaaattt gaagtcgaaa     1380

aatacattgt ccataaggaa ttcgatgatg acacttacga caatgacatt gcgctgctgc     1440

agctgaaatc ggattcgtcc cgctgtgccc aggagagcag cgtggtccgc actgtgtgcc     1500

ttcccccggc ggacctgcag ctgccggact ggacggagtg tgagctctcc ggctacggca     1560

agcatgaggc cttgtctcct ttctattcgg agcggctgaa ggaggctcat gtcagactgt     1620

acccatccag ccgctgcaca tcacaacatt tacttaacag aacagtcacc gacaacatgc     1680

tgtgtgctgg agacactcgg agcggcgggc cccaggcaaa cttgcacgac gcctgccagg     1740

gcgattcggg aggccccctg gtgtgtctga acgatggccg catgactttg gtgggcatca     1800

tcagctgggg cctgggctgt ggacagaagg atgtcccggg tgtgtacacc aaggttacca     1860

actacctaga ctggattcgt gacaacatgc gaccgtgacc aggaacaccc gactcctcaa     1920

aagcaaatga gatcccgcct cttcttcttc agaagacact gcaaaggcgc agtgcttctc     1980

tacagacttc tccagaccca ccacaccgca gaagcgggac gagaccctac aggagaggga     2040

agagtgcatt ttcccagata cttcccattt tggaagtttt caggacttgg tctgatttca     2100

ggatactctg tcagatggga agacatgaat gcacactagc ctctccagga atgcctcctc     2160

cctgggcaga aagtggccat gccaccctgt tttcagctaa agcccaacct cctgacctgt     2220

caccgtgagc agctttggaa acaggaccac aaaaatgaaa gcatgtctca atagtaaaag     2280

ataacaagat ctttcaggaa agacggattg cattagaaat agacagtata tttatagtca     2340

caagagccca gcagggcctc aaagttgggg caggctggct ggcccgtcat gttcctcaaa     2400

agcacccttg acgtcaagtc tccttcccct ttccccactc cctggctctc agaaggtatt     2460

ccttttgtgt acagtgtgta aagtgtaaat cctttttctt tataaacttt agagtagcat     2520

gagagaattg tatcatttga acaactaggc ttcagcatat ttatagcaat ccatgttagt     2580

ttttactttc tgttgccaca accctgtttt atactgtact taataaattc agatatattt     2640

ttcacagttt ttccaaaatc agagtggaat ggttttgtta tagatgctgt atcccactct     2700

ttattcatgt tcacatttta aaatcatttg gaattctgct tcactcgctt aacatataca     2760

caacacctgt aacatacaag gcaatgggct aggtgctcca gaccgggaaa aggagggaca     2820

ggaatgcttg gtctgatggg ctaatatggc atttagagaa gtaccaaggt acagtggagc     2880

cggtcacaaa agggcagact tgtagtagaa ttcagttgca agagggattg gggaatctta     2940

aggaaaaaat agaatcttaa ggaaaaaata actgggtgag acgtggactg tggacaggtg     3000

tggaaaaggc actctccatg gaggtatgaa tatgtagagg gccaagagag gggagtacag     3060

ggagaaatga gttgagcttg tctgaagtga acttcaggaa gaggaacata ggctggaatt     3120

tagattatgg gggctctgaa caccaaactg agtttggact taattgactt ctg            3173


<210>  60
<211>  562
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(562)
<223>  tissue-type plasminogen activator isoform 1 preproprotein

<400>  60

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  61
<211>  805
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(805)
<223>  Homo sapiens chemokine (C-C motif) ligand 3-like 1 (CCL3L1), 
       transcript variant 1, mRNA

<400>  61
agaaggacgc aggcagcaaa gagtagtcag tcccttcttg gctctgctga cactcgagcc       60

cacattccat cacctgctcc caatcatgca ggtctccact gctgcccttg ccgtcctcct      120

ctgcaccatg gctctctgca accaggtcct ctctgcacca cttgctgctg acacgccgac      180

cgcctgctgc ttcagctaca cctcccgaca gattccacag aatttcatag ctgactactt      240

tgagacgagc agccagtgct ccaagcccag tgtcatcttc ctaaccaaga gaggccggca      300

ggtctgtgct gaccccagtg aggagtgggt ccagaaatac gtcagtgacc tggagctgag      360

tgcctgaggg gtccagaagc ttcgaggccc agcgacctca gtgggcccag tggggaggag      420

caggagcctg agccttggga acatgcgtgt gacctctaca gctacctctt ctatggactg      480

gttattgcca aacagccaca ctgtgggact cttcttaact taaattttaa tttatttata      540

ctatttagtt tttataattt atttttgatt tcacagtgtg tttgtgattg tttgctctga      600

gagttccccc tgtcccctcc accttccctc acagtgtgtc tggtgacaac cgagtggctg      660

tcatcggcct gtgtaggcag tcatggcacc aaagccacca gactgacaaa tgtgtatcag      720

atgcttttgt tcagggctgt gatcggcctg gggaaataat aaagatgttc ttttaaacgg      780

taaaaaaaaa aaaaaaaaaa aaaaa                                            805


<210>  62
<211>  93
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  C-C motif chemokine 3-like 1 precursor

<400>  62

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  63
<211>  475
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(475)
<223>  Homo sapiens chemokine (C-C motif) ligand 27 (CCL27), mRNA

<400>  63
cccagataaa aggtagggga ggaggagaga gagagaagga agagtctagg ctgagcaaca       60

tgaaggggcc cccaaccttc tgcagcctcc tgctgctgtc attgctcctg agcccagacc      120

ctacagcagc attcctactg ccacccagca ctgcctgctg tactcagctc taccgaaagc      180

cactctcaga caagctactg aggaaggtca tccaggtgga actgcaggag gctgacgggg      240

actgtcacct ccaggctttc gtgcttcacc tggctcaacg cagcatctgc atccaccccc      300

agaaccccag cctgtcacag tggtttgagc accaagagag aaagctccat gggactctgc      360

ccaagctgaa ttttgggatg ctaaggaaaa tgggctgaag cccccaatag ccaaataata      420

aagcagcatt ggataataat ttctgagtat aatctccaaa aaaaaaaaaa aaaaa           475


<210>  64
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  C-C motif chemokine 27 precursor

<400>  64

Met Lys Gly Pro Pro Thr Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ser Pro Asp Pro Thr Ala Ala Phe Leu Leu Pro Pro Ser Thr Ala 
            20                  25                  30          


Cys Cys Thr Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 
        35                  40                  45              


Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 
    50                  55                  60                  


Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 
65                  70                  75                  80  


Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 
                85                  90                  95      


His Gly Thr Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 
            100                 105                 110         


<210>  65
<211>  3353
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3353)
<223>  Homo sapiens adhesion G protein-coupled receptor E5 (ADGRE5), 
       transcript variant 3, mRNA

<400>  65
caccttcccc tcagagcagc cagccccaac acagaggcca aagggttcgt cagagccaca       60

tggtggaaac tctagcagag ggtttttgaa agcaggttgc acttcattct tactgagtgc      120

acgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgcagcg cccctgggtc      180

tgtgttttta ttgcactttc ctgctggctt ccagctgcac cgccagttcc ggggagggcc      240

ctgggccagc ggctgtccgc cccccctcct tcataaagtc ctggcctcgg gacagcctgc      300

acagctgcct agcctgtgga gacgggacag ccctgtccca ctcactcttt cccctgccgc      360

tcctgccggc agctccaacc atgggaggcc gcgtctttct cgcattctgt gtctggctga      420

ctctgccggg agctgaaacc caggactcca ggggctgtgc ccggtggtgc cctcagaact      480

cctcgtgtgt caatgccacc gcctgtcgct gcaatccagg gttcagctct ttttctgaga      540

tcatcaccac cccgacggag acttgtgacg acatcaacga gtgtgcaaca ccgtcgaaag      600

tgtcatgcgg aaaattctcg gactgctgga acacagaggg gagctacgac tgcgtgtgca      660

gcccgggata tgagcctgtt tctggggcaa aaacattcaa gaatgagagc gagaacacct      720

gtcaagatgt ggacgaatgt cagcagaacc caaggctctg taaaagctac ggcacctgcg      780

tcaacaccct tggcagctat acctgccagt gcctgcctgg cttcaagttc atacctgagg      840

atccgaaggt ctgcacagat gtggacgagt gcagctccgg gcagcatcag tgtgacagct      900

ccaccgtctg cttcaacacc gtgggttcat acagctgccg ctgccgccca ggctggaagc      960

ccagacacgg aatcccgaat aaccaaaagg acactgtctg tgaagatatg actttctcca     1020

cctggacccc gccccctgga gtccacagcc agacgctttc ccgattcttc gacaaagtcc     1080

aggacctggg cagagactcc aagacaagct cagccgaggt caccatccag aatgtcatca     1140

aattggtgga tgaactgatg gaagctcctg gagacgtaga ggccctggcg ccacctgtcc     1200

ggcacctcat agccacccag ctgctctcaa accttgaaga tatcatgagg atcctggcca     1260

agagcctgcc taaaggcccc ttcacctaca tttccccttc gaacacagag ctgaccctga     1320

tgatccagga gcggggggac aagaacgtca ctatgggtca gagcagcgca cgcatgaagc     1380

tgaattgggc tgtggcagct ggagccgagg atccaggccc cgccgtggcg ggcatcctct     1440

ccatccagaa catgacgaca ttgctggcca atgcctcctt gaacctgcat tccaagaagc     1500

aagccgaact ggaggagata tatgaaagca gcatccgtgg tgtccaactc agacgcctct     1560

ctgccgtcaa ctccatcttt ctgagccaca acaacaccaa ggaactcaac tcccccatcc     1620

ttttcgcctt ctcccacctt gagtcctccg atggggaggc gggaagagac cctcctgcca     1680

aggacgtgat gcctgggcca cggcaggagc tgctctgtgc cttctggaag agtgacagcg     1740

acaggggagg gcactgggcc accgagggct gccaggtgct gggcagcaag aacggcagca     1800

ccacctgcca atgcagccac ctgagcagct ttgcgatcct tatggctcat tatgacgtgg     1860

aggactggaa gctgaccctg atcaccaggg tgggactggc gctgtcactc ttctgcctgc     1920

tgctgtgcat cctcactttc ctgctggtgc ggcccatcca gggctcgcgc accaccatac     1980

acctgcacct ctgcatctgc ctcttcgtgg gctccaccat cttcctggcc ggcatcgaga     2040

acgaaggcgg ccaggtgggg ctgcgctgcc gcctggtggc cgggctgctg cactactgtt     2100

tcctggccgc cttctgctgg atgagcctcg aaggcctgga gctctacttt cttgtggtgc     2160

gcgtgttcca aggccagggc ctgagtacgc gctggctctg cctgatcggc tatggcgtgc     2220

ccctgctcat cgtgggcgtc tcggctgcca tctacagcaa gggctacggc cgccccagat     2280

actgctggtt ggactttgag cagggcttcc tctggagctt cttgggacct gtgaccttca     2340

tcattttgtg caatgctgtc attttcgtga ctaccgtctg gaagctcact cagaagtttt     2400

ctgaaatcaa tccagacatg aagaaattaa agaaggcgag ggcgctgacc atcacggcca     2460

tcgcgcagct cttcctgttg ggctgcacct gggtctttgg cctgttcatc ttcgacgatc     2520

ggagcttggt gctgacctat gtgtttacca tcctcaactg cctgcagggc gccttcctct     2580

acctgctgca ctgcctgctc aacaagaagg ttcgggaaga ataccggaag tgggcctgcc     2640

tagttgctgg ggggagcaag tactcagaat tcacctccac cacgtctggc actggccaca     2700

atcagacccg ggccctcagg gcatcagagt ccggcatatg aaggcgcatg gttctggacg     2760

gcccagcagc tcctgtggcc acagcagctt tgtacacgaa gaccatccat cctcccttcg     2820

tccaccactc tactccctcc accctccctc cctgatcccg tgtgccacca ggagggagtg     2880

gcagctatag tctggcacca aagtccagga cacccagtgg ggtggagtcg gagccactgg     2940

tcctgctgct ggctgcctct ctgctccacc ttgtgaccca gggtggggac aggggctggc     3000

ccagggctgc aatgcagcat gttgccctgg cacctgtggc cagtactcgg gacagactaa     3060

gggcgcttgt cccatcctgg acttttcctc tcatgtcttt gctgcagaac tgaagagact     3120

aggcgctggg gctcagcttc cctcttaagc taagactgat gtcagaggcc ccatggcgag     3180

gccccttggg gccactgcct gaggctcacg gtacagaggc ctgccctgcc tggccgggca     3240

ggaggttctc actgttgtga aggttgtaga cgttgtgtaa tgtgttttta tctgttaaaa     3300

tttttcagtg ttgacactta aaattaaaca catgcataca gaagaaaaaa aaa            3353


<210>  66
<211>  786
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(786)
<223>  CD97 antigen isoform 3 preproprotein

<400>  66

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr Val 
                165                 170                 175     


Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys Glu 
        195                 200                 205             


Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln 
    210                 215                 220                 


Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Ser 
225                 230                 235                 240 


Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu Val 
                245                 250                 255     


Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro Pro 
            260                 265                 270         


Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp Ile 
        275                 280                 285             


Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr Ile 
    290                 295                 300                 


Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly Asp 
305                 310                 315                 320 


Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn Trp 
                325                 330                 335     


Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly Ile 
            340                 345                 350         


Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu Asn 
        355                 360                 365             


Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser Ser 
    370                 375                 380                 


Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile Phe 
385                 390                 395                 400 


Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe Ala 
                405                 410                 415     


Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro Pro 
            420                 425                 430         


Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala Phe 
        435                 440                 445             


Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly Cys 
    450                 455                 460                 


Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser His 
465                 470                 475                 480 


Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp Trp 
                485                 490                 495     


Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe Cys 
            500                 505                 510         


Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln Gly 
        515                 520                 525             


Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly 
    530                 535                 540                 


Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly 
545                 550                 555                 560 


Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala 
                565                 570                 575     


Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val 
            580                 585                 590         


Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys Leu 
        595                 600                 605             


Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile 
    610                 615                 620                 


Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu 
625                 630                 635                 640 


Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile Leu 
                645                 650                 655     


Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln Lys 
            660                 665                 670         


Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala 
        675                 680                 685             


Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr Trp 
    690                 695                 700                 


Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr Tyr 
705                 710                 715                 720 


Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu 
                725                 730                 735     


His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala 
            740                 745                 750         


Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr Thr 
        755                 760                 765             


Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu Ser 
    770                 775                 780                 


Gly Ile 
785     


<210>  67
<211>  1997
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1997)
<223>  Homo sapiens afamin (AFM), mRNA

<400>  67
actttctttt gtaaatgtgg tttctacaaa gatgaaacta ctaaaactta caggttttat       60

ttttttcttg ttttttttga ctgaatccct aaccctgccc acacaacctc gggatataga      120

gaacttcaat agtactcaaa aatttataga agataatatt gaatacatca ccatcattgc      180

atttgctcag tatgttcagg aagcaacctt tgaagaaatg gaaaagctgg tgaaagacat      240

ggtagaatac aaagacagat gtatggctga caagacgctc ccagagtgtt caaaattacc      300

taataatgtt ttacaggaaa aaatatgtgc tatggagggg ctgccacaaa agcataattt      360

ctcacactgc tgcagtaagg ttgatgctca aagaagactc tgtttcttct ataacaagaa      420

atctgatgtg ggatttctgc ctcctttccc taccctggat cccgaagaga aatgccaggc      480

ttatgaaagt aacagagaat cccttttaaa tcacttttta tatgaagttg ccagaaggaa      540

cccatttgtc ttcgccccta cacttctaac tgttgctgtt cattttgagg aggtggccaa      600

atcatgttgt gaagaacaaa acaaagtcaa ctgccttcaa acaagggcaa tacctgtcac      660

acaatattta aaagcatttt cttcttatca aaaacatgtc tgtggggcac ttttgaaatt      720

tggaaccaaa gttgtacact ttatatatat tgcgatactc agtcaaaaat tccccaagat      780

tgaatttaag gagcttattt ctcttgtaga agatgtttct tccaactatg atggatgctg      840

tgaaggggat gttgtgcagt gcatccgtga cacgagcaag gttatgaacc atatttgttc      900

aaaacaagat tctatctcca gcaaaatcaa agagtgctgt gaaaagaaaa taccagagcg      960

cggccagtgc ataattaact caaacaaaga tgatagacca aaggatttat ctctaagaga     1020

aggaaaattt actgacagtg aaaatgtgtg tcaagaacga gatgctgacc cagacacctt     1080

ctttgcgaag tttacttttg aatactcaag gagacatcca gacctgtcta taccagagct     1140

tttaagaatt gttcaaatat acaaagatct cctgagaaat tgctgcaaca cagaaaaccc     1200

tccaggttgt taccgttacg cggaagacaa attcaatgag acaactgaga aaagcctcaa     1260

gatggtacaa caagaatgta aacatttcca gaatttgggg aaggatggtt tgaaatacca     1320

ttacctcatc aggctcacga agatagctcc ccaactctcc actgaagaac tggtgtctct     1380

tggcgagaaa atggtgacag ctttcactac ttgctgtacg ctaagtgaag agtttgcctg     1440

tgttgataat ttggcagatt tagtttttgg agagttatgt ggagtaaatg aaaatcgaac     1500

tatcaaccct gctgtggacc actgctgtaa aacaaacttt gccttcagaa ggccctgctt     1560

tgagagtttg aaagctgata aaacatatgt gcctccacct ttctctcaag atttatttac     1620

ctttcacgca gacatgtgtc aatctcagaa tgaggagctt cagaggaaga cagacaggtt     1680

tcttgtcaac ttagtgaagc tgaagcatga actcacagat gaagagctgc agtctttgtt     1740

tacaaatttc gcaaatgtag tggataagtg ctgcaaagca gagagtcctg aagtctgctt     1800

taatgaagag agtccaaaaa ttggcaactg aagccagctg ctggagatat gtaaagaaaa     1860

aagcaccaaa gggaaggctt cctatctgtg tggtgatgaa tcgcatttcc tgagaacaaa     1920

ataaaaggat ttttctgtaa ctgtcacctg aaataataca ttgcagcaag caataaacac     1980

aacattttgt aaagtta                                                    1997


<210>  68
<211>  599
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(599)
<223>  afamin precursor

<400>  68

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  69
<211>  1924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1924)
<223>  Homo sapiens reticulon 4 receptor (RTN4R), mRNA

<400>  69
ctgtgcgccc tgcgcgccct gcgcacccgc ggcccgagcc cagccagagc cgggcggagc       60

ggagcgcgcc gagcctcgtc ccgcggccgg gccggggccg ggccgtagcg gcggcgcctg      120

gatgcggacc cggccgcggg gagacgggcg cccgccccga aacgactttc agtccccgac      180

gcgccccgcc caacccctac gatgaagagg gcgtccgctg gagggagccg gctgctggca      240

tgggtgctgt ggctgcaggc ctggcaggtg gcagccccat gcccaggtgc ctgcgtatgc      300

tacaatgagc ccaaggtgac gacaagctgc ccccagcagg gcctgcaggc tgtgcccgtg      360

ggcatccctg ctgccagcca gcgcatcttc ctgcacggca accgcatctc gcatgtgcca      420

gctgccagct tccgtgcctg ccgcaacctc accatcctgt ggctgcactc gaatgtgctg      480

gcccgaattg atgcggctgc cttcactggc ctggccctcc tggagcagct ggacctcagc      540

gataatgcac agctccggtc tgtggaccct gccacattcc acggcctggg ccgcctacac      600

acgctgcacc tggaccgctg cggcctgcag gagctgggcc cggggctgtt ccgcggcctg      660

gctgccctgc agtacctcta cctgcaggac aacgcgctgc aggcactgcc tgatgacacc      720

ttccgcgacc tgggcaacct cacacacctc ttcctgcacg gcaaccgcat ctccagcgtg      780

cccgagcgcg ccttccgtgg gctgcacagc ctcgaccgtc tcctactgca ccagaaccgc      840

gtggcccatg tgcacccgca tgccttccgt gaccttggcc gcctcatgac actctatctg      900

tttgccaaca atctatcagc gctgcccact gaggccctgg cccccctgcg tgccctgcag      960

tacctgaggc tcaacgacaa cccctgggtg tgtgactgcc gggcacgccc actctgggcc     1020

tggctgcaga agttccgcgg ctcctcctcc gaggtgccct gcagcctccc gcaacgcctg     1080

gctggccgtg acctcaaacg cctagctgcc aatgacctgc agggctgcgc tgtggccacc     1140

ggcccttacc atcccatctg gaccggcagg gccaccgatg aggagccgct ggggcttccc     1200

aagtgctgcc agccagatgc cgctgacaag gcctcagtac tggagcctgg aagaccagct     1260

tcggcaggca atgcgctgaa gggacgcgtg ccgcccggtg acagcccgcc gggcaacggc     1320

tctggcccac ggcacatcaa tgactcaccc tttgggactc tgcctggctc tgctgagccc     1380

ccgctcactg cagtgcggcc cgagggctcc gagccaccag ggttccccac ctcgggccct     1440

cgccggaggc caggctgttc acgcaagaac cgcacccgca gccactgccg tctgggccag     1500

gcaggcagcg ggggtggcgg gactggtgac tcagaaggct caggtgccct acccagcctc     1560

acctgcagcc tcacccccct gggcctggcg ctggtgctgt ggacagtgct tgggccctgc     1620

tgacccccag cggacacaag agcgtgctca gcagccaggt gtgtgtacat acggggtctc     1680

tctccacgcc gccaagccag ccgggcggcc gacccgtggg gcaggccagg ccaggtcctc     1740

cctgatggac gcctgccgcc cgccaccccc atctccaccc catcatgttt acagggttcg     1800

gcggcagcgt ttgttccaga acgccgcctc ccacccagat cgcggtatat agagatatgc     1860

attttatttt acttgtgtaa aaatatcgga cgacgtggaa taaagagctc ttttcttaaa     1920

aaaa                                                                  1924


<210>  70
<211>  473
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(473)
<223>  reticulon-4 receptor precursor

<400>  70

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp 
305                 310                 315                 320 


Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro 
            340                 345                 350         


Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Ser 
        355                 360                 365             


Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe 
    370                 375                 380                 


Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Val Arg Pro 
385                 390                 395                 400 


Glu Gly Ser Glu Pro Pro Gly Phe Pro Thr Ser Gly Pro Arg Arg Arg 
                405                 410                 415     


Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly 
            420                 425                 430         


Gln Ala Gly Ser Gly Gly Gly Gly Thr Gly Asp Ser Glu Gly Ser Gly 
        435                 440                 445             


Ala Leu Pro Ser Leu Thr Cys Ser Leu Thr Pro Leu Gly Leu Ala Leu 
    450                 455                 460                 


Val Leu Trp Thr Val Leu Gly Pro Cys 
465                 470             


<210>  71
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(924)
<223>  Homo sapiens granulysin (GNLY), transcript variant 1, mRNA

<400>  71
gtatctgtgg taaacccagt gacacggggg agatgacata caaaaagggc aggacctgag       60

aaagattaag ctgcaggctc cctgcccata aaacagggtg tgaaaggcat ctcagcggct      120

gccccaccat ggctacctgg gccctcctgc tccttgcagc catgctcctg ggcaacccag      180

gccttgaggt cagtgtgagc cccaagggca agaacacttc tggaagggag agtggatttg      240

gctgggccat ctggatggaa ggtctggtct tctctcgtct gagccctgag tactacgacc      300

tggcaagagc ccacctgcgt gatgaggaga aatcctgccc gtgcctggcc caggagggcc      360

cccagggtga cctgttgacc aaaacacagg agctgggccg tgactacagg acctgtctga      420

cgatagtcca aaaactgaag aagatggtgg ataagcccac ccagagaagt gtttccaatg      480

ctgcgacccg ggtgtgtagg acggggaggt cacgatggcg cgacgtctgc agaaatttca      540

tgaggaggta tcagtctaga gttacccagg gcctcgtggc cggagaaact gcccagcaga      600

tctgtgagga cctcaggttg tgtatacctt ctacaggtcc cctctgagcc ctctcacctt      660

gtcctgtgga agaagcacag gctcctgtcc tcagatcccg ggaacctcag caacctctgc      720

cggctcctcg cttcctcgat ccagaatcca ctctccagtc tccctcccct gactccctct      780

gctgtcctcc cctctcacga gaataaagtg tcaagcaaga ttttagccgc agctgcttct      840

tctttggtgg atttgagggg tgggtgtcag tggcatgctg gggtgagctg tgtagtcctt      900

caataaatgt ctgtcgtgtg tccc                                             924


<210>  72
<211>  172
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(172)
<223>  granulysin isoform 1 precursor

<400>  72

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Glu Val Ser Val Ser Pro Lys Gly Lys Asn Thr Ser Gly 
            20                  25                  30          


Arg Glu Ser Gly Phe Gly Trp Ala Ile Trp Met Glu Gly Leu Val Phe 
        35                  40                  45              


Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala Arg Ala His Leu Arg 
    50                  55                  60                  


Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln Glu Gly Pro Gln Gly 
65                  70                  75                  80  


Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg Asp Tyr Arg Thr Cys 
                85                  90                  95      


Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val Asp Lys Pro Thr Gln 
            100                 105                 110         


Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys Arg Thr Gly Arg Ser 
        115                 120                 125             


Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg 
    130                 135                 140                 


Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu 
145                 150                 155                 160 


Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro Leu 
                165                 170         


<210>  73
<211>  743
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(743)
<223>  Homo sapiens prefoldin subunit 5 (PFDN5), transcript variant 1, 
       mRNA

<400>  73
gaggatcata gagctgtctg gcgcagcgag gcctcccggc gccaccgaga cgcgcagagg       60

acggctagag cgttgctcgc cgagagactt cctcttcgtt aagtcggcct tcccaacatg      120

gcgcagtcta ttaacatcac ggagctgaat ctgccgcagc tagaaatgct caagaaccag      180

ctggaccagg aagtggagtt cttgtccacg tccattgctc agctcaaagt ggtacagacc      240

aagtatgtgg aagccaagga ctgtctgaac gtgctgaaca agagcaacga ggggaaagaa      300

ttactcgtcc cactgacgag ttctatgtat gtccctggga agctgcatga tgtggaacac      360

gtgctcatcg atgtgggaac tgggtactat gtagagaaga cagctgagga tgccaaggac      420

ttcttcaaga ggaagataga ttttctaacc aagcagatgg agaaaatcca accagctctt      480

caggagaagc acgccatgaa acaggccgtc atggaaatga tgagtcagaa gattcagcag      540

ctcacagccc tgggggcagc tcaggctact gctaaggcct gagagttttt gcagaaatgg      600

ggcagaggga caccctttgg gcgtggcttc ctggtgatgg gaagggtctt gtgttttaat      660

gccaataaat gtgccagctg ggcagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaa                                              743


<210>  74
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(154)
<223>  prefoldin subunit 5 isoform alpha

<400>  74

Met Ala Gln Ser Ile Asn Ile Thr Glu Leu Asn Leu Pro Gln Leu Glu 
1               5                   10                  15      


Met Leu Lys Asn Gln Leu Asp Gln Glu Val Glu Phe Leu Ser Thr Ser 
            20                  25                  30          


Ile Ala Gln Leu Lys Val Val Gln Thr Lys Tyr Val Glu Ala Lys Asp 
        35                  40                  45              


Cys Leu Asn Val Leu Asn Lys Ser Asn Glu Gly Lys Glu Leu Leu Val 
    50                  55                  60                  


Pro Leu Thr Ser Ser Met Tyr Val Pro Gly Lys Leu His Asp Val Glu 
65                  70                  75                  80  


His Val Leu Ile Asp Val Gly Thr Gly Tyr Tyr Val Glu Lys Thr Ala 
                85                  90                  95      


Glu Asp Ala Lys Asp Phe Phe Lys Arg Lys Ile Asp Phe Leu Thr Lys 
            100                 105                 110         


Gln Met Glu Lys Ile Gln Pro Ala Leu Gln Glu Lys His Ala Met Lys 
        115                 120                 125             


Gln Ala Val Met Glu Met Met Ser Gln Lys Ile Gln Gln Leu Thr Ala 
    130                 135                 140                 


Leu Gly Ala Ala Gln Ala Thr Ala Lys Ala 
145                 150                 


<210>  75
<211>  1078
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1078)
<223>  Homo sapiens myoglobin (MB), transcript variant 1, mRNA

<400>  75
gcagcctcaa accccagctg ttggggccag gacacccagt gagcccatac ttgctctttt       60

tgtcttcttc agactgcgcc atggggctca gcgacgggga atggcagttg gtgctgaacg      120

tctgggggaa ggtggaggct gacatcccag gccatgggca ggaagtcctc atcaggctct      180

ttaagggtca cccagagact ctggagaagt ttgacaagtt caagcacctg aagtcagagg      240

acgagatgaa ggcgtctgag gacttaaaga agcatggtgc caccgtgctc accgccctgg      300

gtggcatcct taagaagaag gggcatcatg aggcagagat taagcccctg gcacagtcgc      360

atgccaccaa gcacaagatc cccgtgaagt acctggagtt catctcggaa tgcatcatcc      420

aggttctgca gagcaagcat cccggggact ttggtgctga tgcccagggg gccatgaaca      480

aggccctgga gctgttccgg aaggacatgg cctccaacta caaggagctg ggcttccagg      540

gctaggcccc tgccgctccc acccccaccc atctgggccc cgggttcaag agagagcggg      600

gtctgatctc gtgtagccat atagagtttg cttctgagtg tctgctttgt ttagtagagg      660

tgggcaggag gagctgaggg gctggggctg gggtgttgaa gttggctttg catgcccagc      720

gatgcgcctc cctgtgggat gtcatcaccc tgggaaccgg gagtggccct tggctcactg      780

tgttctgcat ggtttggatc tgaattaatt gtcctttctt ctaaatccca accgaacttc      840

ttccaacctc caaactggct gtaaccccaa atccaagcca ttaactacac ctgacagtag      900

caattgtctg attaatcact ggccccttga agacagcaga atgtcccttt gcaatgagga      960

ggagatctgg gctgggcggg ccagctgggg aagcatttga ctatctggaa cttgtgtgtg     1020

cctcctcagg tatggcagtg actcacctgg ttttaataaa acaacctgca acatctca       1078


<210>  76
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(154)
<223>  myoglobin

<400>  76

Met Gly Leu Ser Asp Gly Glu Trp Gln Leu Val Leu Asn Val Trp Gly 
1               5                   10                  15      


Lys Val Glu Ala Asp Ile Pro Gly His Gly Gln Glu Val Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Gly His Pro Glu Thr Leu Glu Lys Phe Asp Lys Phe Lys 
        35                  40                  45              


His Leu Lys Ser Glu Asp Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Ala Thr Val Leu Thr Ala Leu Gly Gly Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Ile Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Val Lys Tyr Leu Glu Phe Ile Ser Glu Cys Ile 
            100                 105                 110         


Ile Gln Val Leu Gln Ser Lys His Pro Gly Asp Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Met Ala 
    130                 135                 140                 


Ser Asn Tyr Lys Glu Leu Gly Phe Gln Gly 
145                 150                 


<210>  77
<211>  2966
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2966)
<223>  Homo sapiens glypican 5 (GPC5), mRNA

<400>  77
acatcccagg ttagctgctg cgagccgagc cgggcggcgg aggcggcggc ggcggcggca       60

gtggcggcag tggcggcagt ggcggcagcg gcagcagttg cagcagtggt ggccagagcg      120

gatgcttgcg ggctccctgc ggctccacta gttttcttcg ccccgcccag ccgcccactc      180

ttctcggcta gggaagaaga ccagagggtg ctcagctgga aaactctggt gtctcagctt      240

agggcctcct ccgggaagag ctaactgctc ccaggtgaag ccggtgcccg cgggcggtcc      300

gtacaccccg cagccggctc gcaccgctcg agagcctcgg ccgctgtgtc ttccacgtct      360

gcagctcagc cagggcgcgc agggcgagtg gggtccactg gcgggtaaag gggaccagga      420

cggcgaggat ggacgcacag acctggcccg tgggctttcg ctgcctcctc cttctggccc      480

tggttgggtc cgcccgcagc gagggcgtgc agacctgcga agaagttcgg aaacttttcc      540

agtggcggct gctgggagct gtcagggggc tgccggattc gccgcgggca ggacctgatc      600

ttcaggtttg catatccaaa aagcctacat gttgcaccag gaagatggag gagagatatc      660

agattgcggc tcgccaggat atgcagcagt ttcttcaaac gtccagctct acattaaagt      720

ttctaatatc tcgaaatgcg gctgcttttc aagaaaccct tgaaactctc atcaaacaag      780

cagaaaatta caccagtata cttttttgca gtacctacag gaacatggcc ttggaggctg      840

ctgcttcggt tcaggagttc ttcactgatg tggggctgta tttatttggt gcggatgtta      900

atcctgaaga atttgtaaac agattttttg acagtctttt tcctctggtc tacaaccacc      960

tcattaaccc tggtgtgact gacagttccc tggaatactc agaatgcatc cggatggctc     1020

gccgggatgt gagtccattt ggtaatattc cccaaagagt aatgggacag atggggaggt     1080

ccctgctgcc cagccgcact tttctgcagg cactcaatct gggcattgaa gtcatcaaca     1140

ccacagacta tctgcacttc tccaaagagt gcagcagagc cctcctgaag atgcaatact     1200

gcccgcactg ccaaggcctg gcgctcacta agccttgtat gggatactgc ctcaatgtca     1260

tgcgaggctg cctggcgcac atggcggagc ttaatccaca ctggcatgca tatatccggt     1320

cgttggaaga actctcggat gcaatgcatg gaacatacga cattggacac gtgctgctga     1380

actttcactt gcttgttaat gatgctgtgt tacaggctca cctcaatgga caaaaattat     1440

tggaacaggt aaataggatt tgtggccgcc ctgtaagaac acccacacaa agcccccgtt     1500

gttcttttga tcagagcaaa gagaagcatg gaatgaagac caccacaagg aacagtgaag     1560

agacgcttgc caacagaaga aaagaattta tcaacagcct tcgactgtac aggtcattct     1620

atggaggtct agctgatcag ctttgtgcta atgaattagc tgctgcagat ggacttccct     1680

gctggaatgg agaagatata gtaaaaagtt atactcagcg tgtggttgga aatggaatca     1740

aagcccagtc tggaaatcct gaagtcaaag tcaaaggaat tgatcctgtg ataaatcaga     1800

ttattgataa actgaagcat gttgttcagt tgttacaggg tagatcaccc aaacctgaca     1860

agtgggaact tcttcagctg ggcagtggtg gaggcatggt tgaacaagtc agtggggact     1920

gtgatgatga agatggttgc gggggatcag gaagtggaga agtcaagagg acactgaaga     1980

tcacagactg gatgccagat gatatgaact tcagtgatgt aaagcaaatc catcaaacag     2040

acactggcag tactttagac acaacaggag caggatgtgc agtggcgact gaatctatga     2100

cattcactct gataagtgtg gtgatgttac ttcccgggat ttggtaactg aactcttctg     2160

tcctgacata ccttactgaa gtctcgattt cttctctctc tgcatatgcc tggaataaga     2220

gatccttttt caatgtaaca attatattta tgaaaagata tgttacacta acttctcaga     2280

agccaagctg aaatattcat aaagtcccta aaactcaacg tttaaatgac acactttaaa     2340

aatatgtctt ttttcaatct aactgaaaac cttcttaact tctaatatat taaatctgaa     2400

gatgtgaagg gcacagaagt gactttgaat aagaagaatt tagtgtatct gtaattttat     2460

tatcaattcc aagccccttc ctttctaaat taaaaatgtt ttcatttgaa agtgtatttg     2520

ccagacaatg aaaacagtat gcagtatttc ttaaagtatt gaaattagaa tatcatgaaa     2580

taaatcaaaa catacaatgg caagtagtat gcatgcatat tcaagagact cttccatttt     2640

tgcaagctgt agaaggaaat gtctgaatgt ctataagtta tggggtagat tcttgagaag     2700

catttcatat aatttcactg aagaaccttg ataattttga cccactgtaa cttagccact     2760

gatgaacctt aaagctgagt attttattaa cacctgattt gtattccatt atattcaaaa     2820

tgcatctttg gtattgtgcc tctgctccca tctctctctt tgcctcatag atttagctat     2880

gttgggaagc acatgcttgc tctaggaata tctccaataa agctgttaac tatttggtgg     2940

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          2966


<210>  78
<211>  572
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(572)
<223>  glypican-5 precursor

<400>  78

Met Asp Ala Gln Thr Trp Pro Val Gly Phe Arg Cys Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Val Gly Ser Ala Arg Ser Glu Gly Val Gln Thr Cys Glu Glu 
            20                  25                  30          


Val Arg Lys Leu Phe Gln Trp Arg Leu Leu Gly Ala Val Arg Gly Leu 
        35                  40                  45              


Pro Asp Ser Pro Arg Ala Gly Pro Asp Leu Gln Val Cys Ile Ser Lys 
    50                  55                  60                  


Lys Pro Thr Cys Cys Thr Arg Lys Met Glu Glu Arg Tyr Gln Ile Ala 
65                  70                  75                  80  


Ala Arg Gln Asp Met Gln Gln Phe Leu Gln Thr Ser Ser Ser Thr Leu 
                85                  90                  95      


Lys Phe Leu Ile Ser Arg Asn Ala Ala Ala Phe Gln Glu Thr Leu Glu 
            100                 105                 110         


Thr Leu Ile Lys Gln Ala Glu Asn Tyr Thr Ser Ile Leu Phe Cys Ser 
        115                 120                 125             


Thr Tyr Arg Asn Met Ala Leu Glu Ala Ala Ala Ser Val Gln Glu Phe 
    130                 135                 140                 


Phe Thr Asp Val Gly Leu Tyr Leu Phe Gly Ala Asp Val Asn Pro Glu 
145                 150                 155                 160 


Glu Phe Val Asn Arg Phe Phe Asp Ser Leu Phe Pro Leu Val Tyr Asn 
                165                 170                 175     


His Leu Ile Asn Pro Gly Val Thr Asp Ser Ser Leu Glu Tyr Ser Glu 
            180                 185                 190         


Cys Ile Arg Met Ala Arg Arg Asp Val Ser Pro Phe Gly Asn Ile Pro 
        195                 200                 205             


Gln Arg Val Met Gly Gln Met Gly Arg Ser Leu Leu Pro Ser Arg Thr 
    210                 215                 220                 


Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp 
225                 230                 235                 240 


Tyr Leu His Phe Ser Lys Glu Cys Ser Arg Ala Leu Leu Lys Met Gln 
                245                 250                 255     


Tyr Cys Pro His Cys Gln Gly Leu Ala Leu Thr Lys Pro Cys Met Gly 
            260                 265                 270         


Tyr Cys Leu Asn Val Met Arg Gly Cys Leu Ala His Met Ala Glu Leu 
        275                 280                 285             


Asn Pro His Trp His Ala Tyr Ile Arg Ser Leu Glu Glu Leu Ser Asp 
    290                 295                 300                 


Ala Met His Gly Thr Tyr Asp Ile Gly His Val Leu Leu Asn Phe His 
305                 310                 315                 320 


Leu Leu Val Asn Asp Ala Val Leu Gln Ala His Leu Asn Gly Gln Lys 
                325                 330                 335     


Leu Leu Glu Gln Val Asn Arg Ile Cys Gly Arg Pro Val Arg Thr Pro 
            340                 345                 350         


Thr Gln Ser Pro Arg Cys Ser Phe Asp Gln Ser Lys Glu Lys His Gly 
        355                 360                 365             


Met Lys Thr Thr Thr Arg Asn Ser Glu Glu Thr Leu Ala Asn Arg Arg 
    370                 375                 380                 


Lys Glu Phe Ile Asn Ser Leu Arg Leu Tyr Arg Ser Phe Tyr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Gln Leu Cys Ala Asn Glu Leu Ala Ala Ala Asp Gly Leu 
                405                 410                 415     


Pro Cys Trp Asn Gly Glu Asp Ile Val Lys Ser Tyr Thr Gln Arg Val 
            420                 425                 430         


Val Gly Asn Gly Ile Lys Ala Gln Ser Gly Asn Pro Glu Val Lys Val 
        435                 440                 445             


Lys Gly Ile Asp Pro Val Ile Asn Gln Ile Ile Asp Lys Leu Lys His 
    450                 455                 460                 


Val Val Gln Leu Leu Gln Gly Arg Ser Pro Lys Pro Asp Lys Trp Glu 
465                 470                 475                 480 


Leu Leu Gln Leu Gly Ser Gly Gly Gly Met Val Glu Gln Val Ser Gly 
                485                 490                 495     


Asp Cys Asp Asp Glu Asp Gly Cys Gly Gly Ser Gly Ser Gly Glu Val 
            500                 505                 510         


Lys Arg Thr Leu Lys Ile Thr Asp Trp Met Pro Asp Asp Met Asn Phe 
        515                 520                 525             


Ser Asp Val Lys Gln Ile His Gln Thr Asp Thr Gly Ser Thr Leu Asp 
    530                 535                 540                 


Thr Thr Gly Ala Gly Cys Ala Val Ala Thr Glu Ser Met Thr Phe Thr 
545                 550                 555                 560 


Leu Ile Ser Val Val Met Leu Leu Pro Gly Ile Trp 
                565                 570         


<210>  79
<211>  6076
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6076)
<223>  Homo sapiens arylsulfatase B (ARSB), transcript variant 1, mRNA

<400>  79
aaaagtgaat acatgatttt atttaactca ttaataagga aattggtaag gtgttaaaac       60

caattcaaag gacaatccaa agaacagatc aggaatacta aaataaatat gcaagcggag      120

gtgaaactgt tttccttggt agtggtggag gggaaggatt gctactccgc tggataaagt      180

tcatttgtgt atatataaat aagaattatt ttccattgtt atttatctat aacttataaa      240

gttgtaaaca acttccacgg aatcagactc aacctggaag ggtatggtct ctaggcaatg      300

caaaaatttt cccctacacc tgttaacaac tataatatct ccagacagag tagacagaaa      360

gtctggatgg caacgggaat ctactggtca tacggctaac ttcctaattc aataagcacg      420

tgactaaagg attttttcct tccactcaga tatttcaggc taactagata ctgtgtgctt      480

cttagtgtca ctgcttagtg ggggagccag ctctgagtgg ggtcatatcc ggacaagcga      540

atgagctatt tattcaatga ccacgcaaca ctccaaatcc tcccagggca acttgaaagt      600

aaccgcacct tccaaagggc accgtgcaat cagactgtgt gtttggcctc ctgtttgcta      660

gtggggagga agcggcttca tgggtgtaca ctacgcataa atgaatgtga aaggctattt      720

agacctctgc cttttcaccg tcctcccacc tgccacaggc tgggctcttg tgctagaaat      780

gacttgctag ctagacatca tggttcagga tctgagtcag aggtttaacc atttataagc      840

ttttttctta tgaaaaattg gcactaatta taatgtctaa ctgtcagagt tgttgcaggc      900

tttacaggag acgcgggctg tgaagatgct ttgtaaattg tgaagcgtta ttaaagaaca      960

catctttttt ttttaggaaa ccacagtgca aatttaattg ccggggaaga taacgggcct     1020

tggtgccctc caagcgtcag ctgagtttcc aagaagccgg gcagcgggcg cccgcgggtt     1080

cgtctctggc tcctcctccg ccacagcagc cgggggcccg ggtcggaggc ggcgggggcc     1140

gagcgcccgg cctcgcaagc ccacggcccg ctgggggtgc cgtcccgcgc cggggcggag     1200

caggccccgg cagcccagtt cctcattcta tcagcggtac aaggggctgg tggcgccaca     1260

ggcgctggga ccgcgggcgg acaaggatgg gtccgcgcgg cgcggcgagc ttgccccgag     1320

gccccggacc tcggcggctg ctcctccccg tcgtcctccc gctgctgctg ctgctgttgt     1380

tggcgccgcc gggctcgggc gccggggcca gccggccgcc ccacctggtc ttcttgctgg     1440

cagacgacct aggctggaac gacgtcggct tccacggctc ccgcatccgc acgccgcacc     1500

tggacgcgct ggcggccggc ggggtgctcc tggacaacta ctacacgcag ccgctgtgca     1560

cgccgtcgcg gagccagctg ctcactggcc gctaccagat ccgtacaggt ttacagcacc     1620

aaataatctg gccctgtcag cccagctgtg ttcctctgga tgaaaaactc ctgccccagc     1680

tcctaaaaga agcaggttat actacccata tggtcggaaa atggcacctg ggaatgtacc     1740

ggaaagaatg ccttccaacc cgccgaggat ttgataccta ctttggatat ctcctgggta     1800

gtgaagatta ttattcccat gaacgctgta cattaattga cgctctgaat gtcacacgat     1860

gtgctcttga ttttcgagat ggcgaagaag ttgcaacagg atataaaaat atgtattcaa     1920

caaacatatt caccaaaagg gctatagccc tcataactaa ccatccacca gagaagcctc     1980

tgtttctcta ccttgctctc cagtctgtgc atgagcccct tcaggtccct gaggaatact     2040

tgaagccata tgactttatc caagacaaga acaggcatca ctatgcagga atggtgtccc     2100

ttatggatga agcagtagga aatgtcactg cagctttaaa aagcagtggg ctctggaaca     2160

acacggtgtt catcttttct acagataacg gagggcagac tttggcaggg ggtaataact     2220

ggccccttcg aggaagaaaa tggagcctgt gggaaggagg cgtccgaggg gtgggctttg     2280

tggcaagccc cttgctgaag cagaagggcg tgaagaaccg ggagctcatc cacatctctg     2340

actggctgcc aacactcgtg aagctggcca ggggacacac caatggcaca aagcctctgg     2400

atggcttcga cgtgtggaaa accatcagtg aaggaagccc atcccccaga attgagctgc     2460

tgcataatat tgacccgaac ttcgtggact cttcaccgtg tcccaggaac agcatggctc     2520

cagcaaagga tgactcttct cttccagaat attcagcctt taacacatct gtccatgctg     2580

caattagaca tggaaattgg aaactcctca cgggctaccc aggctgtggt tactggttcc     2640

ctccaccgtc tcaatacaat gtttctgaga taccctcatc agacccacca accaagaccc     2700

tctggctctt tgatattgat cgggaccctg aagaaagaca tgacctgtcc agagaatatc     2760

ctcacatcgt cacaaagctc ctgtcccgcc tacagttcta ccataaacac tcagtccccg     2820

tgtacttccc tgcacaggac ccccgctgtg atcccaaggc cactggggtg tggggccctt     2880

ggatgtagga tttcagggag gctagaaaac ctttcaattg gaagttggac ctcaggcctt     2940

ttctcacgac tcttgtctca tttgttatcc caacctgggt tcacttggcc cttctcttgc     3000

tcttaaacca caccgaggtg tctaatttca acccctaatg catttaagaa gctgataaaa     3060

tctgcaacac tcctgctgtt ggctggagca tgtgtctaga ggtgggggtg gctgggttta     3120

tccccctttc ctaagccttg ggacagctgg gaacttaact tgaaatagga agttctcact     3180

gaatcctgga ggctggaaca gctggctctt ttagactcac aagtcagacg ttcgattccc     3240

ctctgccaat agccagtttt attggagtga atcacatttc ttacgcaaat gaagggagca     3300

gacagtgatt aatggttctg ttggccaagg cttctccctg tcggtgaagg atcatgttca     3360

ggcactccaa gtgaaccacc cctcttggtt caccccttac tcacttatct catcacagag     3420

cataaggccc attttgttgt tcaggtcaac agcaaaatgc ctgcaccatg actgtggctt     3480

ttaaaataaa gaaatgtgtt tttatcgtaa tttatttccc cccagccatt gctcactctg     3540

tctagacttc ctgccacttc caattcttct gtggcttttc ctgcctttcc ttttgacctc     3600

agtagtccta tccctgggaa ggccactttg cttctctacc tgagcacccc tgatttctgg     3660

aacgctgctg agccctgcct tacttttgcc cctagggctg aagctagagg cctccccgta     3720

ataggcggtg gagttgctct gtgaggatgt tcatggtaga cactaagagg gctgggtggg     3780

agatgcttgg ctctgtggca tctgttcagc gaggcttttc ctatattgca tggagttagt     3840

cattgtgatt gtagctttat ttcataatat attaagactt gcactgctat ttactagcag     3900

tgagaagaaa cctcaggaaa ggatatgaaa aagcaagtgg ccagtgtctg ggatactggg     3960

ccttggtaaa gcagaggagg gcacacccac agtcctctta ttctctgttt tactgcttgt     4020

tttgaggttc tggggtctgg caaagaggat gcagtttgac acctgcagcc ctttctcaat     4080

cccactaatg tcttactaat gtggaacagt ccatattagc tccagagagt gtcaaaccca     4140

gagaaatgtg tgcaaaaatg atactctttt ctgcattagc cccaccattg tgttcaccaa     4200

tgcttggaac actgcctgaa ggcactcatt ttttaatttt tattttattt ttaatttttt     4260

atatctttat gagacgatct cactctgtca ccaggttgga gtacagtggt acaatcacaa     4320

ctcaccgtag cctcaaactc ctgggctcaa gtgattctcc cacctcaggc acccaaatag     4380

ctggaactac aggcatatac cgccacaccc agctaatttt attttttgaa aagacaaggt     4440

tccctatgtt gcccagctgg tcttaaactc ctgggctcca gcaattatcc cagcttgggc     4500

tccaaaagtg ctgggattac aggcatgagt caccatgcct ggcctcattt tttaaaacaa     4560

atgaataaat ggacaaatga gtaaatgaga aagtctcaca ccatgaaaga tgctagtcca     4620

atgagctgaa tacagaggta atataaatgt cttccagctg ttgcttttct gttctcaagc     4680

tgcccctcct ggggtaggag cataatctac atcactgggc agtcacagga cactctatag     4740

caaggttgta gcgtcctctc cagtgggggg agaaaaggaa ctgtgcctac caaaggtact     4800

ctcttgtcag caatttccat ttctatactt tatgggacac tagaaactaa aagcaacaaa     4860

taatctgata taagtccttg tatagtcatc cttcaattca gtagcaatat tttctggtca     4920

ctactaacct gtattgtatt aaaatgagac tattggaagg aaatggtgct aaaactaata     4980

acatctctta ccaaccttta cccaactcct gggttggcaa acagctgacc aaactgccat     5040

cacctcccac ttggaagtgt atggccgaca gcatgaaata gctgagccca gatgttcctt     5100

ctgcatcctc cgaatcccag ggctgggtgt aggtagccgt tggaggccat cgctacaggg     5160

cacctatctg ttatcgctgc tgtcctccca acagctgtct ccagttctag ttccttggtt     5220

ttcaggcaca gtgggggatg ttctgcaccc agtggacttc aaaagagttt tgaagactta     5280

attttttgta aaacaagtac ttgagatttt ggtttatcca taatagaatg tatttcatta     5340

gattctctga ttctatataa gaatgtgaaa agattgatat attgttgtta gaaataatgt     5400

tatttctttc caattttttt tttttttttt tttgagatgg agtctcgctc tgtcacccag     5460

gctggagtgc agtggtgtga tctcggctca ctgcagcctc taactcccag gttcaagcta     5520

ttctcctgcc tcagcctccc aagtagctgg attacaggca tacaccacca cgcctggcta     5580

tgttttgtat ttttcgtaga gatagggttt caccatgttg gccaggctgg tctcaaactc     5640

ctgacctcaa gtgatccacc cacttcagct tcccaaagca ctgggattac aggtgtgagc     5700

cactgtgccc ggcaaatttt tttaccttta cagaaggttt tgcttattta attgtgagct     5760

catttttctt tgttactttt gtccccccag atttggggga caaaataaaa ttaatctttt     5820

aaaatgtgtc agccatatgt atggggcttc catttggggt gaggagaaag ttctggaact     5880

agatagtggt catggttata caacatcata aatgcaatta ctgccactga attgtatgtt     5940

ttaaagtggt taaaatgtta agttttatgt tttattacaa tttttaaatg tgtcaaccaa     6000

ctttatagta cataaattat atctcagtaa agctgttaaa taaataaata tagtaaaaat     6060

tttagaacta aaaaaa                                                     6076


<210>  80
<211>  533
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(533)
<223>  arylsulfatase B isoform 1 precursor

<400>  80

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  81
<211>  6061
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6061)
<223>  Homo sapiens sortilin-related VPS10 domain containing receptor 2 
       (SORCS2), mRNA

<400>  81
atggcgcacc gggggccctc gcgcgcctcg aagggccccg gccccaccgc ccgagccccg       60

agccccgggg ctccgccgcc gccgcgctcg ccgcgctcgc ggccgctcct gctgctgctg      120

ctgctgctgg gcgcctgcgg ggcggcgggg cgctcccctg agcccgggcg cctgggtcct      180

cacgcccaac tgacccgggt gccgcggagc cctcccgcgg ggcgcgcgga gcccggtggc      240

ggcgaggacc ggcaggcgcg cggcacggag ccaggcgccc cgggtccgag tcccggtccc      300

gctcctggtc ccggcgagga cggcgccccc gccgcgggct accggcgctg ggagcgggcg      360

gcgccgctgg ccggagtggc ttcgcgggcg caggtctcgc tcatcagcac gtcgttcgtg      420

ctcaaggggg acgcgacgca caaccaggcg atggtgcact ggacgggcga gaacagcagc      480

gtgatcttga tcctgacgaa gtactaccac gcagacatgg ggaaggttct ggaaagttct      540

ctgtggcggt catcagattt cgggacgtcc tacaccaagc tcaccctcca gcctggtgtc      600

accaccgtca tcgacaattt ctacatctgc ccgaccaaca agaggaaggt catccttgtc      660

agctcctcac tcagtgaccg ggaccagagc ctattcctca gcgcagacga aggcgccacc      720

tttcagaagc agcccattcc cttcttcgtg gaaactctga ttttccaccc taaggaggag      780

gacaaggtcc tcgcctacac aaaggagagc aagctctacg tgtcatctga cttggggaaa      840

aagtggacac ttctgcaaga gcgagtgacc aaagaccacg tgttctggtc tgtgtctggg      900

gtggacgctg accctgactt ggtccacgtg gaagcccaag acctcggtgg agattttcgg      960

tacgtcacct gcgcaatcca caattgctcc gagaagatgc tgacagcccc attcgcaggc     1020

cccattgacc acgggtctct gaccgtgcag gacgattaca tcttctttaa ggcaacatca     1080

gcaaaccaga caaaatacta cgtctcttat cgtcgaaatg aatttgtcct gatgaagctg     1140

ccgaagtatg cattgccaaa ggatctgcag atcatcagca cggacgagag tcaggtgttc     1200

gtggcggtgc aggagtggta ccagatggac acctacaacc tgtaccagtc ggacccacgg     1260

ggcgtgcgct acgcgctggt gctgcaggac gtgcgcagct cacggcaggc ggaggagagc     1320

gtgctcatcg acatcctgga ggtcagaggg gtgaaaggag tcttcctggc aaaccaaaaa     1380

attgatggga aagtgatgac gcttataacc tacaacaagg gccgcgactg ggattacctg     1440

aggccaccca gcatggacat gaatggaaaa ccaaccaact gcaagcctcc agactgccac     1500

ctgcacctgc acctgcgctg ggcagacaac ccctacgtat caggcaccgt gcacaccaag     1560

gacaccgccc caggcctcat catgggtgca ggtaacctgg gctcacagct ggtggaatat     1620

aaagaagaaa tgtacatcac gtcagactgt ggtcacacct ggcggcaggt gtttgaggaa     1680

gagcatcaca tcctgtacct ggaccacggc ggcgtgatcg tggccatcaa agacacctcc     1740

atccctttga agatcctcaa gttcagtgtg gacgagggcc tcacctggag cacgcacaac     1800

ttcaccagca cctcggtgtt tgtggacggg ctgctgagtg agccagggga cgagacgctg     1860

gtcatgacgg tctttggcca catcagcttc cgctccgatt gggagctggt caaggtggac     1920

ttccggccct cattctccag gcagtgcggc gaggaggact acagctcctg ggagctctcc     1980

aacctgcagg gcgaccgctg tatcatgggc cagcagagaa gtttccggaa aagaaagtcc     2040

acgtcctggt gcatcaaggg gaggagcttc acgtcggcgc tcacgtcccg cgtgtgcgag     2100

tgccgggact cggacttcct gtgcgactac ggatttgagc gctcctcctc ctcagagtcc     2160

agcaccaaca agtgctctgc caacttctgg tttaacccat tgtccccgcc tgacgactgt     2220

gccctgggcc agacctacac cagcagcctt gggtaccgga aagtggtgtc caacgtgtgt     2280

gagggtgggg tggacatgca gcagagtcag gtgcagctgc agtgccccct cacgccgccc     2340

cggggcctgc aggtcagcat tcaaggcgag gcggtggccg tgcggcctgg agaggacgtc     2400

ctgtttgtgg tgcggcagga gcagggtgat gtcctgacta ccaagtacca ggtagacctt     2460

ggggacggct tcaaggccat gtacgtgaac cttacactga ccggggagcc catccggcac     2520

cgctacgaga gccccggcat ctaccgcgtg tccgtcaggg cagagaacac ggcaggccac     2580

gatgaggcgg tgctctttgt ccaggtcaac tcccccctgc aggccctcta cctggaggtg     2640

gttcctgtca ttggcctcaa ccaggaggtg aacctcacag ctgtgctgct tcccttgaac     2700

cctaacctca ccgtcttcta ctggtggatc ggccacagcc tgcagcccct cctttccctg     2760

gataattctg tgacaacgcg gttttcggac acgggcgacg tgcgtgtgac ggtgcaggcc     2820

gcctgtggga actcggtgct gcaggactcc agggtcctcc gtgtgctgga tcaatttcaa     2880

gtcatgcctc tgcagttttc caaggagctg gatgcctaca accccaacac ccctgagtgg     2940

agggaagacg tgggcctggt ggtcacccgg ctgctctcca aggagaccag cgtccctcag     3000

gagcttctgg tgactgtggt gaagccgggg ctgcccactt tggccgatct gtacgtgctc     3060

ctgccccctc ccaggcccac aaggaagagg agcctctcga gtgataagag gctcgccgcc     3120

atccagcagg tgctgaacgc acagaagatc agcttcctcc tgcgaggcgg agtccgggtc     3180

ctggtggccc tgcgggacac aggcacaggt gctgagcagc tgggcggcgg tggcggctac     3240

tgggcggtag tggtgctgtt tgtcatcggg ctcttcgcag cgggagcctt catcctctac     3300

aagttcaaaa ggaaacggcc aggcaggacc gtgtacgccc aaatgcacaa cgagaaggag     3360

caggagatga ccagccctgt gagtcacagt gaggacgtcc agggcgctgt ccagggcaac     3420

cactcaggcg tggtcctgag catcaactcc cgagagatgc acagctacct ggtgagctga     3480

tgccacccca gcatctgtct tttcacccac ggagggcaca gaaccaccag caaagccggc     3540

ggctggactg gcgcccctca gagacctgcg gaaagccccc tccctgagtc gtcgccacac     3600

caggcgacag gcaccacccc ctctgataaa tccaagcccg cccaggccca cggggggccc     3660

acgggacccc ccgggactcc ccggacatgg ccctgcccct atgggacacc aggcctgact     3720

caggcaggtt ctgcccccca gaccccacac acggccgccc cacgtgctgt cgctcagccc     3780

gaggcctgac ttctctgggc tgaggctggt cgtcctggag ccctcccagt acctcgggct     3840

gcaagagctg cagacccgtt cagacactgc gttgcgggct ccttccccgc agaggccggg     3900

gcctccctga ctttgcttct tcactcccac ctgtgcggcc acccagtccc tctgtgggag     3960

cccgggtgcc aggccctccc aacaccacac caccctccag gcccccctgc cctccggctg     4020

gaaactgcag ctctgtaaat gcctctctag gtagctgctg gcggtggtgg gggtgtctca     4080

ctctctgtct ttatagccgg cggtagccac cggggtggct ctgtcagagt tccgtactcg     4140

ggagcccctt tccctgagtg cccagggtgt ctcctctgcc cagaggggca gcagctctcc     4200

ctggttctcc ccagggcaga cggggtaggg cgggctcagg acccagtgcc catggttcct     4260

cactcctacc agcaagcagc accatcccgc aggcttctcc cacctgatgg ctgttctccc     4320

accgggtctg ggctctggaa ggagccagat gcccccagaa aggtgggtgg tggagacggc     4380

accagatgta ccagttttct gcagttcctt ataggcgaag ggaaccgggt ggaaaccaag     4440

ctgggagagg ctgaggatgg cagggctgga agggccatca gcgtgaccct cattttcaag     4500

aaggggaaac tgaggcccag ggaggagagt aactgaaggt cacagcacgg tcacagcaga     4560

ggtggccgaa cccagccctc tgcgcgccag tgctgtgcgg tctccacacc cttacggttt     4620

cctagaatca gggatgttag tgtaagtcta taggaatata ggggggtggg ggggtcacct     4680

tttgccttga aatgggaagt cagtagcccc ttcctcctcc tccctcctcc ccctcctctc     4740

tggcagggat ctcagatgac cgtggcctcc ctctcagagg gggagaacgc cagagccctg     4800

gctggtgatg tgctggctgg gggtgaatcc caatgagggt ccctctcaga gcgggagaac     4860

gccagagccc tggatggtga tgcgctggct gggggtgaat cccaatgagg gtccctctca     4920

gaaagggaga acgccagagc cctggctggt gacatgctgg ctgggggtga atccgaatga     4980

cagtgcagac gttctcccat ccaccatgtc tgagcttggg ggaattgcct catttcccct     5040

ggaaaagaaa catggtccat tagaggggaa agcccagggg tgaatcttca cgccccaaac     5100

agtgcccggt ggggaggagg cacccgctcc ttgttgagta aaaccaccca tggagactgg     5160

aacctcatct ccctgggtcg gggggtgttc aaggccacag gacaagggga gcaccctggg     5220

ccacacaggc gtggaggtgt ccccacccct tccacctgtc ccccagaccc aaagctctct     5280

ccccacccta cctgcccacc tggggctcct gtgccccctc cccactccag aggccaccct     5340

acaagttgtc ctcaaggtca tcctggagat gggatccagg acgtggggcc atgactctct     5400

gggaccttgc cacagccccc attcccctgc ttgcagtctg caaggacacc tttgcaggga     5460

ttcttgtcct gctggccacc ccacccacac ctgtccctgg ccagcaggcc gcctgcaagc     5520

gtcaggcaca cagggacaga catggcgagc acagtgcagg cccggggccc acgggcaaca     5580

tggaaccctg ggaactgccc tcccccttag ctcacagtgc ctgcggtagc cactctaggt     5640

cgttggcctt ccttgaccac tccatttaat tctctctgct gtttgggttg ggtttttccc     5700

cttagttatc tgtgggtttc ctgtatttta tgttaatatt tctattaaga acatgttggg     5760

catgtggacc caagcacctg ggaaggaggt ggcatctgag acagcctgat acgttcccgt     5820

ctgtgcaccc atggagatcc aggcgtgggc ccgtgtctgt ccctggttgt aaattcgagg     5880

gtctgcatat ctgatgttca ggtagacctg ggcgcctggg aacgaggcca tcagctgcca     5940

tgcacataac aaagagacaa tgcattcctt cttatttttc ctttttaaaa atcgatgaat     6000

catttgtgat gcttttaaca aagattaaat gaatttgatc agcttttgcc ttaaaaaaaa     6060

a                                                                     6061


<210>  82
<211>  1159
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1159)
<223>  VPS10 domain-containing receptor SorCS2 precursor

<400>  82

Met Ala His Arg Gly Pro Ser Arg Ala Ser Lys Gly Pro Gly Pro Thr 
1               5                   10                  15      


Ala Arg Ala Pro Ser Pro Gly Ala Pro Pro Pro Pro Arg Ser Pro Arg 
            20                  25                  30          


Ser Arg Pro Leu Leu Leu Leu Leu Leu Leu Leu Gly Ala Cys Gly Ala 
        35                  40                  45              


Ala Gly Arg Ser Pro Glu Pro Gly Arg Leu Gly Pro His Ala Gln Leu 
    50                  55                  60                  


Thr Arg Val Pro Arg Ser Pro Pro Ala Gly Arg Ala Glu Pro Gly Gly 
65                  70                  75                  80  


Gly Glu Asp Arg Gln Ala Arg Gly Thr Glu Pro Gly Ala Pro Gly Pro 
                85                  90                  95      


Ser Pro Gly Pro Ala Pro Gly Pro Gly Glu Asp Gly Ala Pro Ala Ala 
            100                 105                 110         


Gly Tyr Arg Arg Trp Glu Arg Ala Ala Pro Leu Ala Gly Val Ala Ser 
        115                 120                 125             


Arg Ala Gln Val Ser Leu Ile Ser Thr Ser Phe Val Leu Lys Gly Asp 
    130                 135                 140                 


Ala Thr His Asn Gln Ala Met Val His Trp Thr Gly Glu Asn Ser Ser 
145                 150                 155                 160 


Val Ile Leu Ile Leu Thr Lys Tyr Tyr His Ala Asp Met Gly Lys Val 
                165                 170                 175     


Leu Glu Ser Ser Leu Trp Arg Ser Ser Asp Phe Gly Thr Ser Tyr Thr 
            180                 185                 190         


Lys Leu Thr Leu Gln Pro Gly Val Thr Thr Val Ile Asp Asn Phe Tyr 
        195                 200                 205             


Ile Cys Pro Thr Asn Lys Arg Lys Val Ile Leu Val Ser Ser Ser Leu 
    210                 215                 220                 


Ser Asp Arg Asp Gln Ser Leu Phe Leu Ser Ala Asp Glu Gly Ala Thr 
225                 230                 235                 240 


Phe Gln Lys Gln Pro Ile Pro Phe Phe Val Glu Thr Leu Ile Phe His 
                245                 250                 255     


Pro Lys Glu Glu Asp Lys Val Leu Ala Tyr Thr Lys Glu Ser Lys Leu 
            260                 265                 270         


Tyr Val Ser Ser Asp Leu Gly Lys Lys Trp Thr Leu Leu Gln Glu Arg 
        275                 280                 285             


Val Thr Lys Asp His Val Phe Trp Ser Val Ser Gly Val Asp Ala Asp 
    290                 295                 300                 


Pro Asp Leu Val His Val Glu Ala Gln Asp Leu Gly Gly Asp Phe Arg 
305                 310                 315                 320 


Tyr Val Thr Cys Ala Ile His Asn Cys Ser Glu Lys Met Leu Thr Ala 
                325                 330                 335     


Pro Phe Ala Gly Pro Ile Asp His Gly Ser Leu Thr Val Gln Asp Asp 
            340                 345                 350         


Tyr Ile Phe Phe Lys Ala Thr Ser Ala Asn Gln Thr Lys Tyr Tyr Val 
        355                 360                 365             


Ser Tyr Arg Arg Asn Glu Phe Val Leu Met Lys Leu Pro Lys Tyr Ala 
    370                 375                 380                 


Leu Pro Lys Asp Leu Gln Ile Ile Ser Thr Asp Glu Ser Gln Val Phe 
385                 390                 395                 400 


Val Ala Val Gln Glu Trp Tyr Gln Met Asp Thr Tyr Asn Leu Tyr Gln 
                405                 410                 415     


Ser Asp Pro Arg Gly Val Arg Tyr Ala Leu Val Leu Gln Asp Val Arg 
            420                 425                 430         


Ser Ser Arg Gln Ala Glu Glu Ser Val Leu Ile Asp Ile Leu Glu Val 
        435                 440                 445             


Arg Gly Val Lys Gly Val Phe Leu Ala Asn Gln Lys Ile Asp Gly Lys 
    450                 455                 460                 


Val Met Thr Leu Ile Thr Tyr Asn Lys Gly Arg Asp Trp Asp Tyr Leu 
465                 470                 475                 480 


Arg Pro Pro Ser Met Asp Met Asn Gly Lys Pro Thr Asn Cys Lys Pro 
                485                 490                 495     


Pro Asp Cys His Leu His Leu His Leu Arg Trp Ala Asp Asn Pro Tyr 
            500                 505                 510         


Val Ser Gly Thr Val His Thr Lys Asp Thr Ala Pro Gly Leu Ile Met 
        515                 520                 525             


Gly Ala Gly Asn Leu Gly Ser Gln Leu Val Glu Tyr Lys Glu Glu Met 
    530                 535                 540                 


Tyr Ile Thr Ser Asp Cys Gly His Thr Trp Arg Gln Val Phe Glu Glu 
545                 550                 555                 560 


Glu His His Ile Leu Tyr Leu Asp His Gly Gly Val Ile Val Ala Ile 
                565                 570                 575     


Lys Asp Thr Ser Ile Pro Leu Lys Ile Leu Lys Phe Ser Val Asp Glu 
            580                 585                 590         


Gly Leu Thr Trp Ser Thr His Asn Phe Thr Ser Thr Ser Val Phe Val 
        595                 600                 605             


Asp Gly Leu Leu Ser Glu Pro Gly Asp Glu Thr Leu Val Met Thr Val 
    610                 615                 620                 


Phe Gly His Ile Ser Phe Arg Ser Asp Trp Glu Leu Val Lys Val Asp 
625                 630                 635                 640 


Phe Arg Pro Ser Phe Ser Arg Gln Cys Gly Glu Glu Asp Tyr Ser Ser 
                645                 650                 655     


Trp Glu Leu Ser Asn Leu Gln Gly Asp Arg Cys Ile Met Gly Gln Gln 
            660                 665                 670         


Arg Ser Phe Arg Lys Arg Lys Ser Thr Ser Trp Cys Ile Lys Gly Arg 
        675                 680                 685             


Ser Phe Thr Ser Ala Leu Thr Ser Arg Val Cys Glu Cys Arg Asp Ser 
    690                 695                 700                 


Asp Phe Leu Cys Asp Tyr Gly Phe Glu Arg Ser Ser Ser Ser Glu Ser 
705                 710                 715                 720 


Ser Thr Asn Lys Cys Ser Ala Asn Phe Trp Phe Asn Pro Leu Ser Pro 
                725                 730                 735     


Pro Asp Asp Cys Ala Leu Gly Gln Thr Tyr Thr Ser Ser Leu Gly Tyr 
            740                 745                 750         


Arg Lys Val Val Ser Asn Val Cys Glu Gly Gly Val Asp Met Gln Gln 
        755                 760                 765             


Ser Gln Val Gln Leu Gln Cys Pro Leu Thr Pro Pro Arg Gly Leu Gln 
    770                 775                 780                 


Val Ser Ile Gln Gly Glu Ala Val Ala Val Arg Pro Gly Glu Asp Val 
785                 790                 795                 800 


Leu Phe Val Val Arg Gln Glu Gln Gly Asp Val Leu Thr Thr Lys Tyr 
                805                 810                 815     


Gln Val Asp Leu Gly Asp Gly Phe Lys Ala Met Tyr Val Asn Leu Thr 
            820                 825                 830         


Leu Thr Gly Glu Pro Ile Arg His Arg Tyr Glu Ser Pro Gly Ile Tyr 
        835                 840                 845             


Arg Val Ser Val Arg Ala Glu Asn Thr Ala Gly His Asp Glu Ala Val 
    850                 855                 860                 


Leu Phe Val Gln Val Asn Ser Pro Leu Gln Ala Leu Tyr Leu Glu Val 
865                 870                 875                 880 


Val Pro Val Ile Gly Leu Asn Gln Glu Val Asn Leu Thr Ala Val Leu 
                885                 890                 895     


Leu Pro Leu Asn Pro Asn Leu Thr Val Phe Tyr Trp Trp Ile Gly His 
            900                 905                 910         


Ser Leu Gln Pro Leu Leu Ser Leu Asp Asn Ser Val Thr Thr Arg Phe 
        915                 920                 925             


Ser Asp Thr Gly Asp Val Arg Val Thr Val Gln Ala Ala Cys Gly Asn 
    930                 935                 940                 


Ser Val Leu Gln Asp Ser Arg Val Leu Arg Val Leu Asp Gln Phe Gln 
945                 950                 955                 960 


Val Met Pro Leu Gln Phe Ser Lys Glu Leu Asp Ala Tyr Asn Pro Asn 
                965                 970                 975     


Thr Pro Glu Trp Arg Glu Asp Val Gly Leu Val Val Thr Arg Leu Leu 
            980                 985                 990         


Ser Lys Glu Thr Ser Val Pro Gln  Glu Leu Leu Val Thr  Val Val Lys 
        995                 1000                 1005             


Pro Gly  Leu Pro Thr Leu Ala  Asp Leu Tyr Val Leu  Leu Pro Pro 
    1010                 1015                 1020             


Pro Arg  Pro Thr Arg Lys Arg  Ser Leu Ser Ser Asp  Lys Arg Leu 
    1025                 1030                 1035             


Ala Ala  Ile Gln Gln Val Leu  Asn Ala Gln Lys Ile  Ser Phe Leu 
    1040                 1045                 1050             


Leu Arg  Gly Gly Val Arg Val  Leu Val Ala Leu Arg  Asp Thr Gly 
    1055                 1060                 1065             


Thr Gly  Ala Glu Gln Leu Gly  Gly Gly Gly Gly Tyr  Trp Ala Val 
    1070                 1075                 1080             


Val Val  Leu Phe Val Ile Gly  Leu Phe Ala Ala Gly  Ala Phe Ile 
    1085                 1090                 1095             


Leu Tyr  Lys Phe Lys Arg Lys  Arg Pro Gly Arg Thr  Val Tyr Ala 
    1100                 1105                 1110             


Gln Met  His Asn Glu Lys Glu  Gln Glu Met Thr Ser  Pro Val Ser 
    1115                 1120                 1125             


His Ser  Glu Asp Val Gln Gly  Ala Val Gln Gly Asn  His Ser Gly 
    1130                 1135                 1140             


Val Val  Leu Ser Ile Asn Ser  Arg Glu Met His Ser  Tyr Leu Val 
    1145                 1150                 1155             


Ser 
    


