                         SEQUENCE LISTING

<110>  The Salk Institute for Biological Studies
 
<120>  FIBROBLAST GROWTH FACTOR (FGF) 1 PROTEINS WITH GLUCOSE LOWERING 
       ABILITY AND REDUCED MITOGENICITY

<130>  7158-97127-02

<150>  US 62/369,460
<151>  2016-08-01

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  468
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(468)

<400>  1
atg gct gaa ggg gaa atc acc acc ttc aca gcc ctg acc gag aag ttt         48
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe           
1               5                   10                  15                

aat ctg cct cca ggg aat tac aag aag ccc aaa ctc ctc tac tgt agc         96
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser           
            20                  25                  30                    

aac ggg ggc cac ttc ctg agg atc ctt ccg gat ggc aca gtg gat ggg        144
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly           
        35                  40                  45                        

aca agg gac agg agc gac cag cac att cag ctg cag ctc agt gcg gaa        192
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu           
    50                  55                  60                            

agc gtg ggg gag gtg tat ata aag agt acc gag act ggc cag tac ttg        240
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu           
65                  70                  75                  80            

gcc atg gac acc gac ggg ctt tta tac ggc tca cag aca cca aat gag        288
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu           
                85                  90                  95                

gaa tgt ttg ttc ctg gaa agg ctg gag gag aac cat tac aac acc tat        336
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr           
            100                 105                 110                   

ata tcc aag aag cat gca gag aag aat tgg ttt gtt ggc ctc aag aag        384
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys           
        115                 120                 125                       

aat ggg agc tgc aaa cgc ggt cct cgg act cac tat ggc cag aaa gca        432
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala           
    130                 135                 140                           

atc ttg ttt ctc ccc ctg cca gtc tct tct gat taa                        468
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp                               
145                 150                 155                               


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  3
<211>  468
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(468)

<400>  3
atg gct gaa ggg gag atc aca acc ttc gca gcc ctg acc gag agg ttc         48
Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe           
1               5                   10                  15                

aac ctg cct cta gga aac tac aaa aag ccc aaa ctg ctc tac tgc agc         96
Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser           
            20                  25                  30                    

aac ggg ggc cac ttc ttg agg atc ctt cct gat ggc acc gtg gat ggg        144
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly           
        35                  40                  45                        

aca agg gac agg agc gac cag cac att cag ctg cag ctc agt gcg gaa        192
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu           
    50                  55                  60                            

agt gcg ggc gaa gtg tat ata aag ggt acg gag acc ggc cag tac ttg        240
Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu           
65                  70                  75                  80            

gcc atg gac acc gaa ggg ctt tta tac ggc tcg cag aca cca aat gag        288
Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu           
                85                  90                  95                

gaa tgt ctg ttc ctg gaa agg ctg gaa gaa aac cat tat aac act tac        336
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr           
            100                 105                 110                   

acc tcc aag aag cat gcg gag aag aac tgg ttt gtg ggc ctc aag aag        384
Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys           
        115                 120                 125                       

aac ggg agc tgt aag cgc ggt cct cgg act cac tat ggc cag aaa gcc        432
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala           
    130                 135                 140                           

atc ttg ttt ctg ccc ctc ccg gtg tct tct gac tag                        468
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp                               
145                 150                 155                               


<210>  4
<211>  155
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  5
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  6
<211>  155
<212>  PRT
<213>  Gorilla gorilla

<400>  6

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  7
<211>  155
<212>  PRT
<213>  Pan troglodytes

<400>  7

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  8
<211>  155
<212>  PRT
<213>  Canis familiaris

<400>  8

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Met Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  9
<211>  155
<212>  PRT
<213>  Felis catus

<400>  9

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  10
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  10

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Val Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Cys Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Val Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Ser Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  11
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  11

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Trp Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu His Arg Leu Glu Glu Asn His Tyr Asn Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Arg Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  12
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  12

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Val Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Trp Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Val Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Arg Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  13
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  13

Met Arg Asp Ser Ser Pro Leu Pro Val Leu Leu Tyr Cys Ser Asn Gly 
1               5                   10                  15      


Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg 
            20                  25                  30          


Asp Arg Ser Asp Gln His Ile Gln Phe Gln Leu Ser Ala Glu Ser Val 
        35                  40                  45              


Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met 
    50                  55                  60                  


Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Thr 
65                  70                  75                  80  


Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Val Thr Tyr Ile Ser 
                85                  90                  95      


Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly 
            100                 105                 110         


Ser Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu 
        115                 120                 125             


Trp Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135         


<210>  14
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  14

Met Arg Asp Ser Ser Pro Leu Pro Val Leu Leu Tyr Cys Ser Asn Gly 
1               5                   10                  15      


Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg 
            20                  25                  30          


Asp Arg Ser Asp Gln His Ile Gln Phe Gln Leu Ser Ala Glu Ser Val 
        35                  40                  45              


Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met 
    50                  55                  60                  


Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys 
65                  70                  75                  80  


Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Val Thr Tyr Ile Ser 
                85                  90                  95      


Lys Lys Tyr Ala Glu Lys Asn Trp Tyr Val Gly Leu Lys Lys Asn Gly 
            100                 105                 110         


Ser Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu 
        115                 120                 125             


Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135         


<210>  15
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  15

Met Arg Asp Ser Ser Pro Leu Pro Val Leu Leu Tyr Cys Ser Asn Gly 
1               5                   10                  15      


Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg 
            20                  25                  30          


Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val 
        35                  40                  45              


Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met 
    50                  55                  60                  


Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys 
65                  70                  75                  80  


Leu Phe Leu Val Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser 
                85                  90                  95      


Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly 
            100                 105                 110         


Ser Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu 
        115                 120                 125             


Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135         


<210>  16
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  16

Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly 
1               5                   10                  15      


Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln 
            20                  25                  30          


Leu Ile Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        35                  40                  45              


Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    50                  55                  60                  


Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly 
65                  70                  75                  80  


Tyr Val Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val 
                85                  90                  95      


Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr 
            100                 105                 110         


Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
        115                 120                 125         


<210>  17
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  17

Leu Tyr Cys Ser Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly 
1               5                   10                  15      


Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Phe Gln 
            20                  25                  30          


Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        35                  40                  45              


Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    50                  55                  60                  


Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His 
65                  70                  75                  80  


Tyr Val Thr Tyr Ile Ser Lys Lys Tyr Ala Glu Lys Asn Trp Tyr Val 
                85                  90                  95      


Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr 
            100                 105                 110         


Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
        115                 120                 125         


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  18

Leu Tyr Cys Ser Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly 
1               5                   10                  15      


Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Phe Gln 
            20                  25                  30          


Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        35                  40                  45              


Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    50                  55                  60                  


Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His 
65                  70                  75                  80  


Tyr Val Thr Tyr Ile Ser Lys Lys Tyr Ala Glu Lys Asn Trp Tyr Val 
                85                  90                  95      


Gly Leu Lys Lys Asn Gly Ser Val Lys Arg Gly Pro Arg Thr His Tyr 
            100                 105                 110         


Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
        115                 120                 125         


<210>  19
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  19

Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly 
1               5                   10                  15      


Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Phe Gln 
            20                  25                  30          


Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        35                  40                  45              


Gly Gln Tyr Leu Cys Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    50                  55                  60                  


Thr Pro Asn Glu Glu Thr Leu Phe Leu Glu Arg Leu Glu Glu Asn His 
65                  70                  75                  80  


Tyr Val Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val 
                85                  90                  95      


Gly Leu Lys Lys Asn Gly Ser Val Lys Arg Gly Pro Arg Thr His Tyr 
            100                 105                 110         


Gly Gln Lys Ala Ile Leu Trp Leu Pro Leu Pro Val Ser Ser Asp 
        115                 120                 125         


<210>  20
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  20

Met Arg Asp Ser Ser Pro Leu Leu Tyr Cys Ser Asn Gly Gly Tyr Phe 
1               5                   10                  15      


Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser 
            20                  25                  30          


Asp Gln His Ile Gln Phe Gln Leu Ser Ala Glu Ser Val Gly Glu Val 
        35                  40                  45              


Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp 
    50                  55                  60                  


Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu 
65                  70                  75                  80  


Glu Arg Leu Glu Glu Asn His Tyr Val Thr Tyr Ile Ser Lys Lys Tyr 
                85                  90                  95      


Ala Glu Lys Asn Trp Tyr Val Gly Leu Lys Lys Asn Gly Ser Val Lys 
            100                 105                 110         


Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro 
        115                 120                 125             


Leu Pro Val Ser Ser Asp 
    130                 


<210>  21
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  21

Met Arg Asp Ser Ser Pro Leu Gly Gly Gln Val Leu Tyr Cys Ser Asn 
1               5                   10                  15      


Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr 
            20                  25                  30          


Arg Asp Arg Ser Asp Gln His Ile Gln Phe Gln Leu Ser Ala Glu Ser 
        35                  40                  45              


Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala 
    50                  55                  60                  


Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu 
65                  70                  75                  80  


Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Val Thr Tyr Ile 
                85                  90                  95      


Ser Lys Lys Tyr Ala Glu Lys Asn Trp Tyr Val Gly Leu Lys Lys Asn 
            100                 105                 110         


Gly Ser Val Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile 
        115                 120                 125             


Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135             


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  22

Val Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro 
1               5                   10                  15      


Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Pro His Ile Gln 
            20                  25                  30          


Leu Gln Leu Ile Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr 
        35                  40                  45              


Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly 
    50                  55                  60                  


Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu 
65                  70                  75                  80  


Asn Gly Tyr Val Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp 
                85                  90                  95      


Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr 
            100                 105                 110         


His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser 
        115                 120                 125             


Asp 
    


<210>  23
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  23

Val Leu Leu Tyr Cys Ser Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro 
1               5                   10                  15      


Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln 
            20                  25                  30          


Phe Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr 
        35                  40                  45              


Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly 
    50                  55                  60                  


Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu 
65                  70                  75                  80  


Asn His Tyr Val Thr Tyr Ile Ser Lys Lys Tyr Ala Glu Lys Asn Trp 
                85                  90                  95      


Tyr Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr 
            100                 105                 110         


His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser 
        115                 120                 125             


Asp 
    


<210>  24
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  24

Val Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro 
1               5                   10                  15      


Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln 
            20                  25                  30          


Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr 
        35                  40                  45              


Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly 
    50                  55                  60                  


Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu 
65                  70                  75                  80  


Asn His Tyr Val Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp 
                85                  90                  95      


Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr 
            100                 105                 110         


His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser 
        115                 120                 125             


Asp 
    


<210>  25
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FGF1

<400>  25

Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr 
                85                  90                  95      


Tyr Ile Ala Lys Glu Ala Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210>  26
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of FGF2

<400>  26

Pro Ala Leu Pro Glu Asp Gly Gly Ala Ala Phe Pro Pro Gly His Phe 
1               5                   10                  15      


Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg 
            20                  25                  30          


Ile His Pro Asp Gly Arg Val Arg Glu Lys Ser Asp Pro His Val Lys 
        35                  40                  45              


Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val 
    50                  55                  60                  


Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala 
65                  70                  75                  80  


Ser Lys Cys Val Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser 
                85                  90                  95      


Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val 
            100                 105                 110         


Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro 
        115                 120                 125             


Gly Gln Lys Ala Ile Leu Phe Leu Phe Met Ser Ala Lys Ser 
    130                 135                 140         


