                         SEQUENCE LISTING

<110>  Efranat Ltd.
 
<120>  ENRICHED MODIFIED VITAMIN D BINDING PROTEIN COMPOSITIONS AND USE 
       THEREOF

<130>  EFNT-P-10-PC

<150>  62/371069
<151>  2016-08-04

<150>  62/443837
<151>  2017-01-09

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be Asp (D) or Glu (E)

<400>  1

Leu Lys Ala Lys Leu Pro Xaa Ala Thr Pro Thr Glu Leu Ala Lys Leu 
1               5                   10                  15      


Val Asn Lys Arg 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Lys Ala Lys Leu Pro Asp Ala Thr Pro Thr Glu Leu Ala Lys Leu 
1               5                   10                  15      


Val Asn Lys Arg 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Lys Ala Lys Leu Pro Glu Ala Thr Pro Thr Glu Leu Ala Lys Leu 
1               5                   10                  15      


Val Asn Lys Arg 
            20  


<210>  4
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
1               5                   10                  15      


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
            20                  25                  30          


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
        35                  40                  45              


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
    50                  55                  60                  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
65                  70                  75                  80  


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
                85                  90                  95      


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
            100                 105                 110         


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
        115                 120                 125             


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
    130                 135                 140                 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
145                 150                 155                 160 


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
                165                 170                 175     


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
            180                 185                 190         


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
        195                 200                 205             


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
    210                 215                 220                 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
225                 230                 235                 240 


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
                245                 250                 255     


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
            260                 265                 270         


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
        275                 280                 285             


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
    290                 295                 300                 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
305                 310                 315                 320 


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
                325                 330                 335     


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
            340                 345                 350         


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
        355                 360                 365             


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
    370                 375                 380                 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
385                 390                 395                 400 


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
                405                 410                 415     


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
            420                 425                 430         


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
        435                 440                 445             


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
    450                 455             


<210>  5
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
1               5                   10                  15      


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
            20                  25                  30          


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
        35                  40                  45              


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
    50                  55                  60                  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
65                  70                  75                  80  


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
                85                  90                  95      


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
            100                 105                 110         


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
        115                 120                 125             


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
    130                 135                 140                 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
145                 150                 155                 160 


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
                165                 170                 175     


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
            180                 185                 190         


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
        195                 200                 205             


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
    210                 215                 220                 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
225                 230                 235                 240 


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
                245                 250                 255     


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
            260                 265                 270         


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
        275                 280                 285             


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
    290                 295                 300                 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
305                 310                 315                 320 


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
                325                 330                 335     


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
            340                 345                 350         


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
        355                 360                 365             


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
    370                 375                 380                 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
385                 390                 395                 400 


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Glu 
                405                 410                 415     


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
            420                 425                 430         


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
        435                 440                 445             


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
    450                 455             


