
                                SEQUENCE LISTING

<110> Juno Therapeutics, Inc.
      HAUSKINS, Colin
      HEIPEL, Mark D.
      SUTHERLAND, Claire L.
      SATHALIYA, Taher
      SMITH, Jeff

<120> ANTI-IDIOTYPIC ANTIBODIES AND RELATED
  METHODS

<130> 735042006540

<140> Not Yet Assigned    
<141> Concurrently Herewith           

<150> 62/369,008          
<151> 2016-07-29  

<160> 164

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID VH

<400> 1
Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe
    50                  55                  60                  
Lys Arg Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120         


<210> 2
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID CH

<400> 2
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
 1               5                  10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His
305                 310                 315                 320 
Ser Pro Gly Lys
                


<210> 3
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID heavy chain

<400> 3
Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe
    50                  55                  60                  
Lys Arg Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro
        115                 120                 125             
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met
    130                 135                 140                 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val
            180                 185                 190         
Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His
        195                 200                 205             
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys
    210                 215                 220                 
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe
225                 230                 235                 240 
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro
                245                 250                 255     
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val
            260                 265                 270         
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr
        275                 280                 285             
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu
    290                 295                 300                 
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys
305                 310                 315                 320 
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro
            340                 345                 350         
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile
        355                 360                 365             
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly
    370                 375                 380                 
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp
385                 390                 395                 400 
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp
                405                 410                 415     
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His
            420                 425                 430         
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys
        435                 440                 445     


<210> 4
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC signal sequence

<400> 4
Met Gly Trp Ser Ser Ile Ile Leu Phe Leu Val Ala Thr Ala Ser Gly
 1               5                  10                  15      
Val His Ser
            


<210> 5
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID VL

<400> 5
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Val Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID CL

<400> 6
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu
 1               5                  10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu
65                  70                  75                  80  
Arg His Asn Asn Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
            100                 105         


<210> 7
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID light chain

<400> 7
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Val Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Asn Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys
    210                 


<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC signal sequence

<400> 8
Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln
 1               5                  10                  15      
Gly Thr Arg Cys
            20  


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR1

<400> 9
Ser Tyr Trp Met His
 1               5  


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR2

<400> 10
Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe Lys
 1               5                  10                  15      
Arg
    


<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR3

<400> 11
Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr
 1               5                  10              


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR1

<400> 12
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
 1               5                  10      


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR2

<400> 13
Tyr Thr Ser Arg Leu His Ser
 1               5          


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR3

<400> 14
Gln Gln Gly Lys Thr Val Pro Phe Thr
 1               5                  


<210> 15
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID VH

<400> 15
caggtccaac tgcaacaacc tgggtctgag ctggtgaggc ctggaggttc agtgaagctg 60
tcctgcaagg cttctgacta cactttcacc agctactgga tgcactgggt gaggcagagg 120
cctggacaag gccttgagtg gattggaaat atttatcctg gtagtggtgg tactaactac 180
gatgagaagt tcaagaggaa ggccacactg actgtagaca catcctccag cacagcctac 240
atgcagctcc gcagcctgac atctgaggac tctgcggtct attactgtac aagagaggtt 300
actacagtag cttattacta ttctatggac tactggggtc aaggaacctc agtcaccgtc 360
tcctca                                                            366

<210> 16
<211> 975
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID CH

<400> 16
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac 60
tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc 120
tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac 180
ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc 240
acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg 300
gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc 360
cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg 420
gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag 480
gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc 540
agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc 600
aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg 660
aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc 720
agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg 780
aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct 840
tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc 900
acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac 960
tctcctggta aatga                                                  975

<210> 17
<211> 1341
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID heavy chain

<400> 17
caggtccaac tgcaacaacc tgggtctgag ctggtgaggc ctggaggttc agtgaagctg 60
tcctgcaagg cttctgacta cactttcacc agctactgga tgcactgggt gaggcagagg 120
cctggacaag gccttgagtg gattggaaat atttatcctg gtagtggtgg tactaactac 180
gatgagaagt tcaagaggaa ggccacactg actgtagaca catcctccag cacagcctac 240
atgcagctcc gcagcctgac atctgaggac tctgcggtct attactgtac aagagaggtt 300
actacagtag cttattacta ttctatggac tactggggtc aaggaacctc agtcaccgtc 360
tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa 420
actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca 480
gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag 540
tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag 600
accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg 660
cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc 720
atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt 780
gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat 840
gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc 900
tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc 960
agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc 1020
agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat 1080
aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg 1140
cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat 1200
ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat 1260
actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc 1320
tcccactctc ctggtaaatg a                                           1341

<210> 18
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID HC signal sequence

<400> 18
atgggatgga gctctatcat cctcttcttg gtagcaacag cctcaggtgt ccactcc    57

<210> 19
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID VL

<400> 19
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc 60
atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca 120
gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca 180
aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa 240
gaagatattg ccacttactt ttgtcagcag ggtaaaacgg ttccattcac gttcggctcg 300
gggacaaagt tggaaataaa a                                           321

<210> 20
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID CL

<400> 20
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct 60
ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag 120
tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac 180
agcaaagaca gcacctacag catgagcagc accctcacgt tgaccaagga cgagtatgaa 240
cgacataaca actatacctg tgaggccact cacaagacat caacttcacc cattgtcaag 300
agcttcaaca ggaatgagtg ttag                                        324

<210> 21
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID light chain

<400> 21
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc 60
atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca 120
gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca 180
aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa 240
gaagatattg ccacttactt ttgtcagcag ggtaaaacgg ttccattcac gttcggctcg 300
gggacaaagt tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca 360
tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac 420
cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg 480
aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg 540
ttgaccaagg acgagtatga acgacataac aactatacct gtgaggccac tcacaagaca 600
tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                 645

<210> 22
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID LC signal sequence

<400> 22
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt 60


<210> 23
<211> 122
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 VH

<400> 23
Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
    50                  55                  60                  
Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 24
<211> 108
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 VL

<400> 24
Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile
        35                  40                  45              
Tyr Ser Ala Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser
65                  70                  75                  80  
Lys Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr
                85                  90                  95      
Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 25
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4GS linker

<400> 26
Gly Gly Gly Gly Ser
 1               5  


<210> 27
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> An extracellular portion of CD28

<400> 27
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro
        35                  


<210> 28
<211> 245
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 scFv

<400> 28
Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
    50                  55                  60                  
Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser
    130                 135                 140                 
Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys
145                 150                 155                 160 
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys
                165                 170                 175     
Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe
        195                 200                 205             
Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe
    210                 215                 220                 
Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys
225                 230                 235                 240 
Leu Glu Ile Lys Arg
                245 


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3GS linker

<400> 29
Gly Gly Gly Ser
 1              


<210> 30
<211> 120
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 VH

<400> 30
Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr
            20                  25                  30          
Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 31
<211> 107
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 VL

<400> 31
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
            100                 105         


<210> 32
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 Fc lacking hinge

<400> 32
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
 1               5                  10                  15      
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
            20                  25                  30          
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
        35                  40                  45              
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
    50                  55                  60                  
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
65                  70                  75                  80  
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
                85                  90                  95      
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
            100                 105                 110         
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
        115                 120                 125             
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
    130                 135                 140                 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
145                 150                 155                 160 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
                165                 170                 175     
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
            180                 185                 190         
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
        195                 200                 205             
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215                 220 


<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 33
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr
 1               5                  10                  15      
Lys Gly
        


<210> 34
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> FMC63 scFv

<400> 34
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225                 230                 235                 240 
Val Thr Val Ser Ser
                245 


<210> 35
<211> 465
<212> PRT
<213> Artificial Sequence

<220> 
<223> FMC63 reagent

<400> 35
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225                 230                 235                 240 
Val Thr Val Ser Ser Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
                245                 250                 255     
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
            260                 265                 270         
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
        275                 280                 285             
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
    290                 295                 300                 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
305                 310                 315                 320 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
                325                 330                 335     
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
            340                 345                 350         
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
        355                 360                 365             
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
    370                 375                 380                 
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
385                 390                 395                 400 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
                405                 410                 415     
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
            420                 425                 430         
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
        435                 440                 445             
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
    450                 455                 460                 
Lys
465 


<210> 36
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 VH

<400> 36
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Met Lys Trp Val Lys Gln Cys His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120         


<210> 37
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 CH

<400> 37
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly
 1               5                  10                  15      
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
    50                  55                  60                  
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
                85                  90                  95      
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys
            100                 105                 110         
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro
        115                 120                 125             
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp
145                 150                 155                 160 
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg
                165                 170                 175     
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln
            180                 185                 190         
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn
        195                 200                 205             
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly
    210                 215                 220                 
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu
225                 230                 235                 240 
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met
                245                 250                 255     
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu
            260                 265                 270         
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe
        275                 280                 285             
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn
    290                 295                 300                 
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr
305                 310                 315                 320 
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
                325                 330 


<210> 38
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 heavy chain

<400> 38
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Met Lys Trp Val Lys Gln Cys His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro
        115                 120                 125             
Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser
    130                 135                 140                 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val
            180                 185                 190         
Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His
        195                 200                 205             
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro
    210                 215                 220                 
Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu
                245                 250                 255     
Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu
        275                 280                 285             
Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr
    290                 295                 300                 
Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser
305                 310                 315                 320 
Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln
            340                 345                 350         
Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val
        355                 360                 365             
Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val
    370                 375                 380                 
Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg
                405                 410                 415     
Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val
            420                 425                 430         
Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg
        435                 440                 445             
Thr Pro Gly Lys
    450         


<210> 39
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC signal sequence

<400> 39
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val Leu Ser
            


<210> 40
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 VL

<400> 40
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Ile Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
        35                  40                  45              
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105     


<210> 41
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 CL

<400> 41
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu
 1               5                  10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu
65                  70                  75                  80  
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
            100                 105         


<210> 42
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 light chain

<400> 42
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Ile Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
        35                  40                  45              
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro
            100                 105                 110         
Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125             
Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140                 
Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 
Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190         
Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205             
Asn Arg Asn Glu Cys
    210             


<210> 43
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC signal sequence

<400> 43
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Met Ser Ala Ser
 1               5                  10                  15      
Val Ile Met Ser Arg Gly
            20          


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR1

<400> 44
Asp Tyr Tyr Met Lys
 1               5  


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR2

<400> 45
Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Asn Phe Lys
 1               5                  10                  15      
Gly
    


<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR3

<400> 46
Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr
 1               5                  10              


<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR1

<400> 47
Ser Ala Ser Ser Gly Val Ile Tyr Met Tyr
 1               5                  10  


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR2

<400> 48
Leu Thr Ser Asn Leu Ala Ser
 1               5          


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR3

<400> 49
Gln Gln Trp Ser Ser Asn Pro Leu Thr
 1               5                  


<210> 50
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 VH

<400> 50
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagatg 60
tcctgtaagg cttctggata cacattcact gactactaca tgaagtgggt gaagcagtgt 120
catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactgactac 180
aaccagaact ttaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac 240
atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagagagggg 300
aataactacg gtagtagaga tgctatggac tactggggtc aaggaacgtc agtcaccgtc 360
tcctca                                                            366

<210> 51
<211> 990
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 CH

<400> 51
gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaactggc 60
tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc 120
tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctgtcct gcagtctgac 180
ctctacaccc tcagcagctc agtgactgta acctcgagca cctggcccag ccagtccatc 240
acctgcaatg tggcccaccc ggcaagcagc accaaggtgg acaagaaaat tgagcccaga 300
gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga 360
ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc 420
atagtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg 480
tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac 540
agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag 600
gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca 660
aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag 720
atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt 780
tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc 840
ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg 900
gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg 960
actaagagct tctcccggac tccgggtaaa                                  990

<210> 52
<211> 1356
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 heavy chain

<400> 52
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagatg 60
tcctgtaagg cttctggata cacattcact gactactaca tgaagtgggt gaagcagtgt 120
catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactgactac 180
aaccagaact ttaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac 240
atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagagagggg 300
aataactacg gtagtagaga tgctatggac tactggggtc aaggaacgtc agtcaccgtc 360
tcctcagcca aaacaacagc cccatcggtc tatccactgg cccctgtgtg tggagataca 420
actggctcct cggtgactct aggatgcctg gtcaagggtt atttccctga gccagtgacc 480
ttgacctgga actctggatc cctgtccagt ggtgtgcaca ccttcccagc tgtcctgcag 540
tctgacctct acaccctcag cagctcagtg actgtaacct cgagcacctg gcccagccag 600
tccatcacct gcaatgtggc ccacccggca agcagcacca aggtggacaa gaaaattgag 660
cccagagggc ccacaatcaa gccctgtcct ccatgcaaat gcccagcacc taacctcttg 720
ggtggaccat ccgtcttcat cttccctcca aagatcaagg atgtactcat gatctccctg 780
agccccatag tcacatgtgt ggtggtggat gtgagcgagg atgacccaga tgtccagatc 840
agctggtttg tgaacaacgt ggaagtacac acagctcaga cacaaaccca tagagaggat 900
tacaacagta ctctccgggt ggtcagtgcc ctccccatcc agcaccagga ctggatgagt 960
ggcaaggagt tcaaatgcaa ggtcaacaac aaagacctcc cagcgcccat cgagagaacc 1020
atctcaaaac ccaaagggtc agtaagagct ccacaggtat atgtcttgcc tccaccagaa 1080
gaagagatga ctaagaaaca ggtcactctg acctgcatgg tcacagactt catgcctgaa 1140
gacatttacg tggagtggac caacaacggg aaaacagagc taaactacaa gaacactgaa 1200
ccagtcctgg actctgatgg ttcttacttc atgtacagca agctgagagt ggaaaagaag 1260
aactgggtgg aaagaaatag ctactcctgt tcagtggtcc acgagggtct gcacaatcac 1320
cacacgacta agagcttctc ccggactccg ggtaaa                           1356

<210> 53
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC signal sequence

<400> 53
atgggatgga gctggatctt tctcttcctc ttgtcaggaa ctgcaggtgt cctctct    57

<210> 54
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 VL

<400> 54
caaattgttc tcacccagtc tccagcactc atgtctgcat ctccagggga gaaggtcacc 60
atgacctgca gtgccagctc aggtgtaatt tacatgtact ggtaccaaca gaagccaaga 120
tcctccccca aaccctggat ttatctcaca tccaacctgg cttctggagt ccctgctcgc 180
ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa 240
gatgctgcca cttattactg ccagcagtgg agtagtaacc cgctcacgtt cggtgctggc 300
accaagctgg agctgaaa                                               318

<210> 55
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 CL

<400> 55
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct 60
ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag 120
tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac 180
agcaaagaca gcacctacag catgagcagc accctcacgt tgaccaagga cgagtatgaa 240
cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc cattgtcaag 300
agcttcaaca ggaatgagtg t                                           321

<210> 56
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 light chain

<400> 56
caaattgttc tcacccagtc tccagcactc atgtctgcat ctccagggga gaaggtcacc 60
atgacctgca gtgccagctc aggtgtaatt tacatgtact ggtaccaaca gaagccaaga 120
tcctccccca aaccctggat ttatctcaca tccaacctgg cttctggagt ccctgctcgc 180
ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa 240
gatgctgcca cttattactg ccagcagtgg agtagtaacc cgctcacgtt cggtgctggc 300
accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc 360
agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc 420
aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac 480
agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg 540
accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca 600
acttcaccca ttgtcaagag cttcaacagg aatgagtgt                        639

<210> 57
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC signal sequence

<400> 57
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc 60
agggga                                                            66

<210> 58
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 VH

<400> 58
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Arg Tyr
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ser Ile Tyr Tyr Glu Glu Ala Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 59
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 CH

<400> 59
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala
 1               5                  10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His
305                 310                 315                 320 
Ser Pro Gly Lys
                


<210> 60
<211> 439
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 heavy chain

<400> 60
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Arg Tyr
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ser Ile Tyr Tyr Glu Glu Ala Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro
        115                 120                 125             
Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser
145                 150                 155                 160 
Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu
                165                 170                 175     
Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser
            180                 185                 190         
Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val
        195                 200                 205             
Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys
    210                 215                 220                 
Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys
225                 230                 235                 240 
Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val
                245                 250                 255     
Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp
            260                 265                 270         
Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe
        275                 280                 285             
Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp
    290                 295                 300                 
Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe
305                 310                 315                 320 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys
                325                 330                 335     
Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys
            340                 345                 350         
Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp
        355                 360                 365             
Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys
    370                 375                 380                 
Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser
385                 390                 395                 400 
Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr
                405                 410                 415     
Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser
            420                 425                 430         
Leu Ser His Ser Pro Gly Lys
        435                 


<210> 61
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC signal sequence

<400> 61
Met Gly Trp Ser Ser Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 62
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 VL

<400> 62
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Asp Ser Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 63
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 light chain

<400> 63
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Asp Ser Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys
    210                 


<210> 64
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC signal sequence

<400> 64
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Gly Ala Arg Cys
            20  


<210> 65
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR1

<400> 65
Arg Tyr Trp Met Asn
 1               5  


<210> 66
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR2

<400> 66
Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 67
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR3

<400> 67
Ile Tyr Tyr Glu Glu Ala
 1               5      


<210> 68
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR1

<400> 68
Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala
 1               5                  10      


<210> 69
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR2

<400> 69
Asn Ala Lys Thr Leu Ala Asp
 1               5          


<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR3

<400> 70
Gln His Phe Trp Ser Thr Pro Tyr Thr
 1               5                  


<210> 71
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 VH

<400> 71
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggagcttc agtgaagctg 60
tcctgcaaga cttctggcta ctccttcacc aggtactgga tgaactgggt gaagcagagg 120
cctggacaag gccttgagtg gattggcatg attcatcctt ccgatagtga aactaggtta 180
aatcagaagt tcaaggacaa ggccacattg actgtagaca attcctccag cacagcctac 240
atgcaactca gcagcccgac atctgaggac tctgcggtct attactgtgc aagcatctac 300
tatgaagagg cctggggcca agggactctg gtcactgtct ctgca                 345

<210> 72
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 CH

<400> 72
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac 60
tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc 120
tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac 180
ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc 240
acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg 300
gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc 360
cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg 420
gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag 480
gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc 540
agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc 600
aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg 660
aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc 720
agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg 780
aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct 840
tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc 900
acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac 960
tctcctggta aa                                                     972

<210> 73
<211> 1317
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 heavy chain

<400> 73
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggagcttc agtgaagctg 60
tcctgcaaga cttctggcta ctccttcacc aggtactgga tgaactgggt gaagcagagg 120
cctggacaag gccttgagtg gattggcatg attcatcctt ccgatagtga aactaggtta 180
aatcagaagt tcaaggacaa ggccacattg actgtagaca attcctccag cacagcctac 240
atgcaactca gcagcccgac atctgaggac tctgcggtct attactgtgc aagcatctac 300
tatgaagagg cctggggcca agggactctg gtcactgtct ctgcagccaa aacgacaccc 360
ccatctgtct atccactggc ccctggatct gctgcccaaa ctaactccat ggtgaccctg 420
ggatgcctgg tcaagggcta tttccctgag ccagtgacag tgacctggaa ctctggatcc 480
ctgtccagcg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta cactctgagc 540
agctcagtga ctgtcccctc cagcacctgg cccagcgaga ccgtcacctg caacgttgcc 600
cacccggcca gcagcaccaa ggtggacaag aaaattgtgc ccagggattg tggttgtaag 660
ccttgcatat gtacagtccc agaagtatca tctgtcttca tcttcccccc aaagcccaag 720
gatgtgctca ccattactct gactcctaag gtcacgtgtg ttgtggtaga catcagcaag 780
gatgatcccg aggtccagtt cagctggttt gtagatgatg tggaggtgca cacagctcag 840
acgcaacccc gggaggagca gttcaacagc actttccgct cagtcagtga acttcccatc 900
atgcaccagg actggctcaa tggcaaggag ttcaaatgca gggtcaacag tgcagctttc 960
cctgccccca tcgagaaaac catctccaaa accaaaggca gaccgaaggc tccacaggtg 1020
tacaccattc cacctcccaa ggagcagatg gccaaggata aagtcagtct gacctgcatg 1080
ataacagact tcttccctga agacattact gtggagtggc agtggaatgg gcagccagcg 1140
gagaactaca agaacactca gcccatcatg gacacagatg gctcttactt cgtctacagc 1200
aagctcaatg tgcagaagag caactgggag gcaggaaata ctttcacctg ctctgtgtta 1260
catgagggcc tgcacaacca ccatactgag aagagcctct cccactctcc tggtaaa    1317

<210> 74
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC signal sequence

<400> 74
atgggatgga gctctatcat cctcttcttg gtagcaacag ctacaggtgt ccactcc    57

<210> 75
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 VL

<400> 75
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc 60
atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatag tgtgccatca 180
aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct 240
gaagattttg ggagttatta ctgtcaacat ttttggagta ctccgtacac gttcggaggg 300
gggaccaagc tggaaataaa a                                           321

<210> 76
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 light chain

<400> 76
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc 60
atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatag tgtgccatca 180
aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct 240
gaagattttg ggagttatta ctgtcaacat ttttggagta ctccgtacac gttcggaggg 300
gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca 360
tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac 420
cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg 480
aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg 540
ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca 600
tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                    642

<210> 77
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC signal sequence

<400> 77
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt 60


<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR1

<400> 78
Asp Tyr Thr Phe Thr Ser Tyr
 1               5          


<210> 79
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR1

<400> 79
Asp Tyr Thr Phe Thr Ser Tyr Trp Met His
 1               5                  10  


<210> 80
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR1

<400> 80
Thr Ser Tyr Trp Met His
 1               5      


<210> 81
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR2

<400> 81
Tyr Pro Gly Ser Gly Gly
 1               5      


<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR2

<400> 82
Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn
 1               5                  10  


<210> 83
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR2

<400> 83
Trp Ile Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn
 1               5                  10              


<210> 84
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID HC-CDR3

<400> 84
Thr Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp
 1               5                  10                  


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR1

<400> 85
Ser Asn Tyr Leu Asn Trp Tyr
 1               5          


<210> 86
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR2

<400> 86
Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His
 1               5                  10  


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID LC-CDR3

<400> 87
Gln Gln Gly Lys Thr Val Pro Phe
 1               5              


<210> 88
<211> 7
<212> PRT
<213> anti-ID B-1 HC-CDR1

<400> 88
Gly Tyr Thr Phe Thr Asp Tyr
 1               5          


<210> 89
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR1

<400> 89
Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Lys
 1               5                  10  


<210> 90
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR1

<400> 90
Thr Asp Tyr Tyr Met Lys
 1               5      


<210> 91
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR2

<400> 91
Asn Pro Asn Asn Gly Gly
 1               5      


<210> 92
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR2

<400> 92
Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp
 1               5                  10  


<210> 93
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR2

<400> 93
Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp
 1               5                  10              


<210> 94
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 HC-CDR3

<400> 94
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp
 1               5                  10                  


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR1

<400> 95
Ile Tyr Met Tyr Trp Tyr
 1               5      


<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR2

<400> 96
Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala
 1               5                  10  


<210> 97
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-1 LC-CDR3

<400> 97
Gln Gln Trp Ser Ser Asn Pro Leu
 1               5              


<210> 98
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR1

<400> 98
Gly Tyr Ser Phe Thr Arg Tyr
 1               5          


<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR1

<400> 99
Gly Tyr Ser Phe Thr Arg Tyr Trp Met Asn
 1               5                  10  


<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR1

<400> 100
Thr Arg Tyr Trp Met Asn
 1               5      


<210> 101
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR2

<400> 101
His Pro Ser Asp Ser Glu
 1               5      


<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR2

<400> 102
Met Ile His Pro Ser Asp Ser Glu Thr Arg
 1               5                  10  


<210> 103
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR2

<400> 103
Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg
 1               5                  10              


<210> 104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 HC-CDR3

<400> 104
Ala Ser Ile Tyr Tyr Glu Glu
 1               5          


<210> 105
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR1

<400> 105
His Asn Tyr Leu Ala Trp Tyr
 1               5          


<210> 106
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR2

<400> 106
Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala
 1               5                  10  


<210> 107
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-ID B-2 LC-CDR3

<400> 107
Gln His Phe Trp Ser Thr Pro Tyr
 1               5              


<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 Consensus

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = T or S

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = T or S

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = D or R

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Y or W


<220> 
<221> VARIANT        
<222> 10
<223> Xaa = K or N

<400> 108
Gly Tyr Xaa Phe Xaa Xaa Tyr Xaa Met Xaa
 1               5                  10  


<210> 109
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 Consensus

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = D or M

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = N or H

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = N or S

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = N or D


<220> 
<221> VARIANT        
<222> 10
<223> Xaa = G or S


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = G or E


<220> 
<221> VARIANT        
<222> (13)...(13)
<223> Xaa = D or R


<220> 
<221> VARIANT        
<222> (14)...(14)
<223> Xaa = Y or L


<220> 
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = N or K


<220> 
<221> VARIANT        
<222> (20)...(20)
<223> Xaa = G or D

<400> 109
Trp Ile Gly Xaa Ile Xaa Pro Xaa Xaa Xaa Xaa Thr Xaa Xaa Asn Gln
 1               5                  10                  15      
Xaa Phe Lys Xaa
            20  


<210> 110
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 Consensus

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = R or S

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = E or I

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = G or Y

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = N or Y


<220> 
<221> VARIANT        
<222> 6
<223> Xaa = N or E


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Y or nul


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = G or null


<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = S or null


<220> 
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = R or null


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = D or null


<220> 
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = A or null


<220> 
<221> VARIANT        
<222> (13)...(13)
<223> X13 = M or null


<220> 
<221> VARIANT        
<222> (14)...(14)
<223> X14 = D or E


<220> 
<221> VARIANT        
<222> (15)...(15)
<223> X15 = Y or A

<400> 110
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15  


<210> 111
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 Consensus

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = S or R

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = S or R

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = S or G

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = G or N


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = V or I


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = I or H


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = N or null


<220> 
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = M or L


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Y or A

<400> 111
Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Trp Tyr
 1               5                  10              


<210> 112
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 Consensus

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = P or L

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = W or L

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = I or V

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = L or N


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = T or A


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = S or K


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = N or T


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = S or D

<400> 112
Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Leu Ala Xaa
 1               5                  10      


<210> 113
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 Consensus

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Q or H

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa =W or F

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = S or W

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = S or W


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = N or T


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = L or Y

<400> 113
Gln Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr
 1               5                  


<210> 114
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 HC-CDR1

<400> 114
Ser Tyr Trp Met Asn
 1               5  


<210> 115
<211> 17
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 HC-CDR2

<400> 115
Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 116
<211> 13
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 HC-CDR3

<400> 116
Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr
 1               5                  10              


<210> 117
<211> 11
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 LC-CDR1

<400> 117
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala
 1               5                  10      


<210> 118
<211> 7
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 LC-CDR2

<400> 118
Ser Ala Thr Tyr Arg Asn Ser
 1               5          


<210> 119
<211> 9
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 LC-CDR3

<400> 119
Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr
 1               5                  


<210> 120
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> SJ25C1 LC-CDR3

<400> 120
Asp Tyr Gly Val Ser
 1               5  


<210> 121
<211> 16
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 HC-CDR2

<400> 121
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
 1               5                  10                  15      


<210> 122
<211> 12
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 HC-CDR3

<400> 122
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
 1               5                  10          


<210> 123
<211> 11
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 LC-CDR1

<400> 123
Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn
 1               5                  10      


<210> 124
<211> 7
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 LC-CDR2

<400> 124
His Thr Ser Arg Leu His Ser
 1               5          


<210> 125
<211> 9
<212> PRT
<213> Mus musculus

<220> 
<223> FMC63 LC-CDR3

<400> 125
Gln Gln Gly Asn Thr Leu Pro Tyr Thr
 1               5                  


<210> 126
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A

<400> 126
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp
 1               5                  10                  15      
Val Glu Glu Asn Pro Gly Pro Arg
            20                  


<210> 127
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A

<400> 127
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
 1               5                  10                  15      
Gly Pro
        


<210> 128
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A

<400> 128
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15      
Glu Glu Asn Pro Gly Pro
            20          


<210> 129
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A

<400> 129
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
 1               5                  10                  15      
Pro Gly Pro
            


<210> 130
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A

<400> 130
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
 1               5                  10                  15      
Asn Pro Gly Pro
            20  


<210> 131
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A

<400> 131
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
 1               5                  10                  15      
Glu Ser Asn Pro Gly Pro
            20          


<210> 132
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 heavy chain

<400> 132
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Asp Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Tyr Pro Gly Ser Gly Gly Thr Asp Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 133
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 light chain

<400> 133
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Thr Ser Arg Leu His Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Gly Lys Thr Val Pro Phe
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 134
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 heavy chain

<400> 134
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Thr Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 135
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 light chain

<400> 135
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Gly Lys Thr Val Pro Phe
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 136
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 heavy chain

<400> 136
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe
    50                  55                  60                  
Lys Arg Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Val Thr Thr Val Ala Tyr Tyr Tyr Ser Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 137
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-SJ25C1 light chain

<400> 137
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Thr Ser Arg Leu His Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Gly Lys Thr Val Pro Phe
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 138
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 138
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 139
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 139
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Ser Ala Ser Ser Gly Val Ile Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys
        35                  40                  45              
Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu
65                  70                  75                  80  
Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 140
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 140
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
            20                  25                  30          
Tyr Met Lys Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 141
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 141
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Ser Ala Ser Ser Gly Val Ile Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys
        35                  40                  45              
Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu
65                  70                  75                  80  
Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 142
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 142
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
            20                  25                  30          
Tyr Met Lys Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Asn Asn Tyr Gly Ser Arg Asp Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Leu Val Thr Val Ser
        115                 120                 125             
Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220                 
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365             
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 


<210> 143
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 143
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Ile Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Pro Trp Ile Tyr
        35                  40                  45              
Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu
65                  70                  75                  80  
Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 144
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 144
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Tyr Ser Phe Thr Arg Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile His Pro Ser Asp Ser Glu Thr Asp Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Tyr Tyr Glu Glu Ala Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 145
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 145
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Asn Ala Lys Thr Leu Ala Asp Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 146
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 146
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Tyr
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Tyr Tyr Glu Glu Ala Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 147
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 147
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Asn Ala Lys Thr Leu Ala Asp Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 148
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 heavy chain

<400> 148
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Tyr
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Tyr Asn Thr Pro Phe
    50                  55                  60                  
Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe
65                  70                  75                  80  
Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Ser Ile Tyr Tyr Glu Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 149
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary humanized anti-FMC63 light chain

<400> 149
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 150
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> spacer (IgG4hinge) (aa)

<400> 150
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 151
<211> 36
<212> DNA
<213> Homo sapiens

<220> 
<223> spacer (IgG4hinge) (nt)

<400> 151
gaatctaagt acggaccgcc ctgcccccct tgccct                           36

<210> 152
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Hinge-CH3 spacer

<400> 152
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115                 


<210> 153
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Hinge-CH2-CH3

<400> 153
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 


<210> 154
<211> 282
<212> PRT
<213> Homo sapiens

<220> 
<223> IgD-hinge-Fc

<400> 154
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala
 1               5                  10                  15      
Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala
            20                  25                  30          
Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys
        35                  40                  45              
Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro
    50                  55                  60                  
Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln
65                  70                  75                  80  
Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly
                85                  90                  95      
Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val
            100                 105                 110         
Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly
        115                 120                 125             
Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn
    130                 135                 140                 
Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro
145                 150                 155                 160 
Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys
                165                 170                 175     
Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser
            180                 185                 190         
Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu
        195                 200                 205             
Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro
    210                 215                 220                 
Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser
225                 230                 235                 240 
Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr
                245                 250                 255     
Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg
            260                 265                 270         
Ser Leu Glu Val Ser Tyr Val Thr Asp His
        275                 280         


<210> 155
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> tEGFR

<400> 155
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu
 1               5                  10                  15      
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile
            20                  25                  30          
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe
        35                  40                  45              
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr
    50                  55                  60                  
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
65                  70                  75                  80  
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg
                85                  90                  95      
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile
            100                 105                 110         
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
        115                 120                 125             
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp
    130                 135                 140                 
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
145                 150                 155                 160 
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
                165                 170                 175     
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser
            180                 185                 190         
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
        195                 200                 205             
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln
    210                 215                 220                 
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly
225                 230                 235                 240 
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro
                245                 250                 255     
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr
            260                 265                 270         
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
        275                 280                 285             
Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro
    290                 295                 300                 
Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala
305                 310                 315                 320 
Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
                325                 330                 335 


<210> 156
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> tEGFR

<400> 156
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         


<210> 157
<211> 27
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 (amino acids 153-179 of Accession No. P10747)

<400> 157
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
 1               5                  10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25          


<210> 158
<211> 66
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 (amino acids 114-179 of Accession No. P10747)

<400> 158
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
        35                  40                  45              
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
    50                  55                  60                  
Trp Val
65      


<210> 159
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 (amino acids 180-220 of P10747)

<400> 159
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 160
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 (LL to GG)

<400> 160
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 161
<211> 42
<212> PRT
<213> Homo sapiens

<220> 
<223> 4-1BB (amino acids 214-255 of Q07011.1)

<400> 161
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 162
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 162
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 163
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 163
Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 164
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 164
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         

