                         SEQUENCE LISTING

<110>  PROTAGONIST THERAPEUTICS, INC.
       Bhandari, Ashok
 
<120>  PEPTIDE INHIBITORS OF INTERLEUKIN-23 AND THEIR USE TO TREAT 
       INFLAMMATORY DISEASES

<130>  PRTH-003/01WO 321085-2162

<150>  US 62/367,549
<151>  2016-07-27

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  1

Tyr Met Gln Cys Ile Arg Arg Leu Ile Glu Ala Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Leu Glu Gln Arg Pro Ala Lys Ile Pro Ser Ile Thr Asp Asp 
            20                  25                  30          


Cys 
    


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  2

Phe Asn Met Val Cys Gln Asp Arg Phe Tyr Thr Ala Ala Ala Trp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Phe Arg Asn Ala Phe Ile Leu Ser Leu Arg Asp 
            20                  25                  30          


Phe Cys 
        


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  3

Phe Asn Met Phe Cys Gln Arg Leu Phe Tyr Trp Ala Ala Ala Asn Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Asp Arg Asn Ala Arg Ile Leu Ser Phe Arg Asp 
            20                  25                  30          


Gly Cys 
        


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  4

Phe Asn Met Val Cys Gln Arg Gly Phe Tyr Val Ala Ala Ala Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Phe Arg Asn Ala Leu Ile Leu Ser Leu Arg Asp 
            20                  25                  30          


Phe Cys 
        


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  5

Phe Asn Met Ile Cys Gln Glu Gly Phe Tyr Pro Ala Ala Ala Trp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Phe Arg Asn Ala Phe Ile Leu Ser Leu Arg Asp 
            20                  25                  30          


Phe Cys 
        


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  6

Phe Asn Met Ser Cys Gln Ile Arg Phe Tyr Leu Ala Ala Ala Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Glu Arg Asn Ala Leu Ile Lys Ser Leu Arg Asp 
            20                  25                  30          


Met Cys 
        


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  7

Phe Asn Met Leu Cys Gln Ile Arg Phe Tyr Ile Ala Ala Ala Leu Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Asn Arg Asn Ala Asn Ile Lys Ser Ile Arg Asp 
            20                  25                  30          


Arg Cys 
        


<210>  8
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  8

Phe Asn Met Gln Cys Leu Arg Arg Met Val Glu Ala Gly Ile Asp Pro 
1               5                   10                  15      


Asn Leu Asn Ser Gly Gln Arg Trp Ala Lys Ile Arg Ser Ile Phe Asp 
            20                  25                  30          


Asp Cys 
        


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  9

Phe Asn Met Phe Cys Gln Leu Ala Phe Tyr Ser Ala Ala Ala Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Lys Ile Lys Ser Phe Arg Asp 
            20                  25                  30          


Leu Cys 
        


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  10

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  11

Phe Asn Met Gln Cys Ala Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  12
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  12

Phe Asn Met Gln Cys Leu Arg Arg Ala Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  13
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  13

Phe Asn Met Gln Cys Leu Arg Arg Met Ala Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  14
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  14

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Ala Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  15
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  15

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Ala Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  16
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  16

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Ala 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  17
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  17

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Ala Gln Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  18
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  18

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Ala Glu Gln Arg Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  19

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Ala Trp Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  20
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  20

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Ala Ala Lys Ile Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  21
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  21

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ala Lys Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  22
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized peptide inhibitor of IL23

<400>  22

Phe Asn Met Gln Cys Leu Arg Arg Met Ser Glu Ala Gly Val Asp Pro 
1               5                   10                  15      


Asn Leu Asn Gln Glu Gln Arg Trp Ala Lys Ile Ala Ser Ile Met Asp 
            20                  25                  30          


Asp Cys 
        


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL23 peptide inhibitor amino acid formula


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is any amino acid or is absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa  is an amino acid, an aliphatic acid, an alicyclic acid, or a
       modified 2-methyl aromatic acid each having a side chain with one
       or two carbons and capable of forming a thioether bond with X34

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(12)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (21)..(33)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is Cys, D-Cys, Pen, N-Me-Cys, hCys, D-Pen, D-hCys or hSerCl

<220>
<221>  MISC_FEATURE
<222>  (35)..(39)
<223>  Xaa is any amino acid or is absent

<400>  23

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X30

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(29)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or hCys, hSer(Cl),  N-Me-Cys, 
       Pen(=O), or D-hCys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X29

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(28)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or hCys, hSer(Cl),  N-Me-Cys, 
       Pen(=O), or D-hCys

<400>  25

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  


<210>  26
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X28

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(27)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  26

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25              


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X27

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(26)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  27

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25          


<210>  28
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X26

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(25)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  28

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25      


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X25

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(24)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  29

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X24

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(23)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  30

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  31
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X23

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(22)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  31

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20              


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X22

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  32

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa 
            20          


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X21

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  33

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa 
            20      


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X20

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(19)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  34

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa 
            20  


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X19

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  35

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X18

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  36

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid having a side chain, each with 
       one or two carbons and capable of forming a thioether bond with 
       X18

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu, Ala, Val, Ile, hLeu, Cha, hCha, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Gln, Asn, Glu, Asp or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Cys, D-Cys, Pen, D-Pen or h-Cys, hSer(Cl),  N-Me-Cys or 
       D-hCys

<400>  37

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  38
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL23 peptide inhibitor amino acid formula


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid, an aliphatic acid, an alicyclic acid, or a 
       modified 2-methyl aromatic acid, each having a side chain with 
       one or two carbons and capable of forming a thioether bond with 
       X34

<220>
<221>  MISC_FEATURE
<222>  (6)..(33)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is Cys, D-Cys, Pen, N-Me-Cys, hCys, D-Pen, D-hCys or hSerCl

<220>
<221>  MISC_FEATURE
<222>  (35)..(39)
<223>  Xaa is any amino acid or absent

<400>  38

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


