                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  Methods for decoupling cell growth from production of 
       biochemicals and recombinant polypeptides

<130>  P81602617PCT00

<150>  EP16182046
<151>  2016-07-29

<160>  240   

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  DNA
<213>  Escherichia coli

<400>  1
atgacgttaa ctgcttcatc ttcttcccgc gctgttacga attctcctgt ggttgttgcc       60

cttgattatc ataatcgtga tgacgcgctg gcctttgtcg acaagatcga cccacgcgat      120

tgtcgtctga aggtcggcaa agagatgttt acattgtttg ggccacagtt tgtgcgcgaa      180

cttcaacagc gtggttttga tatctttctt gacctgaaat tccacgatat ccccaacact      240

gcagcgcacg ctgtcgctgc tgcagctgac ttaggcgtgt ggatggtgaa tgttcatgcc      300

tctggtgggg cgcgtatgat gaccgcagcg cgtgaggcac tggttccgtt tggcaaagat      360

gcaccgcttt tgattgctgt gacagtgttg accagcatgg aagccagcga cctggtcgat      420

cttggcatga cactgtcacc tgcagattat gcagaacgtc tggcggcact gacgcaaaaa      480

tgtggccttg atggtgtggt gtgttctgct caggaagctg tgcgctttaa acaggtattc      540

ggtcaggagt tcaaactggt tacgccgggc attcgtccgc aggggagtga agctggtgac      600

cagcgccgca ttatgacgcc agaacaggcg ttgtcggctg gtgttgatta tatggtgatt      660

ggtcgcccgg taacgcaatc ggtagatcca gcgcagacgc tgaaagcgat caacgcctct      720

ttacagcgga gtgcatga                                                    738


<210>  2
<211>  804
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  2
atgtcgaaag ctacatataa ggaacgtgct gctactcatc ctagtcctgt tgctgccaag       60

ctatttaata tcatgcacga aaagcaaaca aacttgtgtg cttcattgga tgttcgtacc      120

accaaggaat tactggagtt agttgaagca ttaggtccca aaatttgttt actaaaaaca      180

catgtggata tcttgactga tttttccatg gagggcacag ttaagccgct aaaggcatta      240

tccgccaagt acaatttttt actcttcgaa gacagaaaat ttgctgacat tggtaataca      300

gtcaaattgc agtactctgc gggtgtatac agaatagcag aatgggcaga cattacgaat      360

gcacacggtg tggtgggccc aggtattgtt agcggtttga agcaggcggc ggaagaagta      420

acaaaggaac ctagaggcct tttgatgtta gcagaattgt catgcaaggg ctccctagct      480

actggagaat atactaaggg tactgttgac attgcgaaga gcgacaaaga ttttgttatc      540

ggctttattg ctcaaagaga catgggtgga agagatgaag gttacgattg gttgattatg      600

acacccggtg tgggtttaga tgacaaggga gacgcattgg gtcaacagta tagaaccgtg      660

gatgatgtgg tctctacagg atctgacatt attattgttg gaagaggact atttgcaaag      720

ggaagggatg ctaaggtaga gggtgaacgt tacagaaaag caggctggga agcatatttg      780

agaagatgcg gccagcaaaa ctaa                                             804


<210>  3
<211>  201
<212>  DNA
<213>  Escherichia coli

<400>  3
atggcaatcc gaaaacgttt tattgcgggc gcaaaatgcc cggcctgtca ggcgcaggat       60

tcaatggcga tgtggcgcga aaataatatt gatattgttg aatgtgttaa gtgcggacat      120

cagatgcgag aagcagacaa agaagcccgc gatcacgttc gcaaagatga gcaagtgatc      180

gggatttttc atccggacta g                                                201


<210>  4
<211>  136
<212>  DNA
<213>  Escherichia coli

<400>  4
gagggtagag cggggtttcc cccgccctgg tagtcttagt aagcggggaa gcttatgact       60

aagagcacca cgatgatgag tagcttcatc atgacccttt ccttatttat ggccccttcc      120

tcgggagggg ctttcc                                                      136


<210>  5
<211>  136
<212>  RNA
<213>  Escherichia coli

<400>  5
gaggguagag cgggguuucc cccgcccugg uagucuuagu aagcggggaa gcuuaugacu       60

aagagcacca cgaugaugag uagcuucauc augacccuuu ccuuauuuau ggccccuucc      120

ucgggagggg cuuucc                                                      136


<210>  6
<211>  18
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Met Lys Leu Leu Ile Ile Val Val Leu Leu Val Ile Ser Phe Pro 
1               5                   10                  15      


Ala Tyr 
        


<210>  7
<211>  506
<212>  PRT
<213>  Flavobacterium johnsoniae

<400>  7

Met Asn Thr Ile Asn Glu Tyr Leu Ser Leu Glu Glu Phe Glu Ala Ile 
1               5                   10                  15      


Ile Phe Gly Asn Gln Lys Val Thr Ile Ser Asp Val Val Val Asn Arg 
            20                  25                  30          


Val Asn Glu Ser Phe Asn Phe Leu Lys Glu Phe Ser Gly Asn Lys Val 
        35                  40                  45              


Ile Tyr Gly Val Asn Thr Gly Phe Gly Pro Met Ala Gln Tyr Arg Ile 
    50                  55                  60                  


Lys Glu Ser Asp Gln Ile Gln Leu Gln Tyr Asn Leu Ile Arg Ser His 
65                  70                  75                  80  


Ser Ser Gly Thr Gly Lys Pro Leu Ser Pro Val Cys Ala Lys Ala Ala 
                85                  90                  95      


Ile Leu Ala Arg Leu Asn Thr Leu Ser Leu Gly Asn Ser Gly Val His 
            100                 105                 110         


Pro Ser Val Ile Asn Leu Met Ser Glu Leu Ile Asn Lys Asp Ile Thr 
        115                 120                 125             


Pro Leu Ile Phe Glu His Gly Gly Val Gly Ala Ser Gly Asp Leu Val 
    130                 135                 140                 


Gln Leu Ser His Leu Ala Leu Val Leu Ile Gly Glu Gly Glu Val Phe 
145                 150                 155                 160 


Tyr Lys Gly Glu Arg Arg Pro Thr Pro Glu Val Phe Glu Ile Glu Gly 
                165                 170                 175     


Leu Lys Pro Ile Gln Val Glu Ile Arg Glu Gly Leu Ala Leu Ile Asn 
            180                 185                 190         


Gly Thr Ser Val Met Thr Gly Ile Gly Val Val Asn Val Tyr His Ala 
        195                 200                 205             


Lys Lys Leu Leu Asp Trp Ser Leu Lys Ser Ser Cys Ala Ile Asn Glu 
    210                 215                 220                 


Leu Val Gln Ala Tyr Asp Asp His Phe Ser Ala Glu Leu Asn Gln Thr 
225                 230                 235                 240 


Lys Arg His Lys Gly Gln Gln Glu Ile Ala Leu Lys Met Arg Gln Asn 
                245                 250                 255     


Leu Ser Asp Ser Thr Leu Ile Arg Lys Arg Glu Asp His Leu Tyr Ser 
            260                 265                 270         


Gly Glu Asn Thr Glu Glu Ile Phe Lys Glu Lys Val Gln Glu Tyr Tyr 
        275                 280                 285             


Ser Leu Arg Cys Val Pro Gln Ile Leu Gly Pro Val Leu Glu Thr Ile 
    290                 295                 300                 


Asn Asn Val Ala Ser Ile Leu Glu Asp Glu Phe Asn Ser Ala Asn Asp 
305                 310                 315                 320 


Asn Pro Ile Ile Asp Val Lys Asn Gln His Val Tyr His Gly Gly Asn 
                325                 330                 335     


Phe His Gly Asp Tyr Ile Ser Leu Glu Met Asp Lys Leu Lys Ile Val 
            340                 345                 350         


Ile Thr Lys Leu Thr Met Leu Ala Glu Arg Gln Leu Asn Tyr Leu Leu 
        355                 360                 365             


Asn Ser Lys Ile Asn Glu Leu Leu Pro Pro Phe Val Asn Leu Gly Thr 
    370                 375                 380                 


Leu Gly Phe Asn Phe Gly Met Gln Gly Val Gln Phe Thr Ala Thr Ser 
385                 390                 395                 400 


Thr Thr Ala Glu Ser Gln Met Leu Ser Asn Pro Met Tyr Val His Ser 
                405                 410                 415     


Ile Pro Asn Asn Asn Asp Asn Gln Asp Ile Val Ser Met Gly Thr Asn 
            420                 425                 430         


Ser Ala Val Ile Thr Ser Lys Val Ile Glu Asn Ala Phe Glu Val Leu 
        435                 440                 445             


Ala Ile Glu Met Ile Thr Ile Val Gln Ala Ile Asp Tyr Leu Gly Gln 
    450                 455                 460                 


Lys Asp Lys Ile Ser Ser Val Ser Lys Lys Trp Tyr Asp Glu Ile Arg 
465                 470                 475                 480 


Asn Ile Ile Pro Thr Phe Lys Glu Asp Gln Val Met Tyr Pro Phe Val 
                485                 490                 495     


Gln Lys Val Lys Asp His Leu Ile Asn Asn 
            500                 505     


<210>  8
<211>  552
<212>  PRT
<213>  Herpetosiphon aurantiacus

<400>  8

Met Ser Thr Thr Leu Ile Leu Thr Gly Glu Gly Leu Gly Ile Asp Asp 
1               5                   10                  15      


Val Val Arg Val Ala Arg His Gln Asp Arg Val Glu Leu Thr Thr Asp 
            20                  25                  30          


Pro Ala Ile Leu Ala Gln Ile Glu Ala Ser Cys Ala Tyr Ile Asn Gln 
        35                  40                  45              


Ala Val Lys Glu His Gln Pro Val Tyr Gly Val Thr Thr Gly Phe Gly 
    50                  55                  60                  


Gly Met Ala Asn Val Ile Ile Ser Pro Glu Glu Ala Ala Glu Leu Gln 
65                  70                  75                  80  


Asn Asn Ala Ile Trp Tyr His Lys Thr Gly Ala Gly Lys Leu Leu Pro 
                85                  90                  95      


Phe Thr Asp Val Arg Ala Ala Met Leu Leu Arg Ala Asn Ser His Met 
            100                 105                 110         


Arg Gly Ala Ser Gly Ile Arg Leu Glu Ile Ile Gln Arg Met Val Thr 
        115                 120                 125             


Phe Leu Asn Ala Asn Val Thr Pro His Val Arg Glu Phe Gly Ser Ile 
    130                 135                 140                 


Gly Ala Ser Gly Asp Leu Val Pro Leu Ile Ser Ile Thr Gly Ala Leu 
145                 150                 155                 160 


Leu Gly Thr Asp Gln Ala Phe Met Val Asp Phe Asn Gly Glu Thr Leu 
                165                 170                 175     


Asp Cys Ile Ser Ala Leu Glu Arg Leu Gly Leu Pro Arg Leu Arg Leu 
            180                 185                 190         


Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly Thr Ser Val Met Thr 
        195                 200                 205             


Gly Ile Ala Ala Asn Cys Val His Asp Ala Arg Ile Leu Leu Ala Leu 
    210                 215                 220                 


Ala Leu Glu Ala His Ala Leu Met Ile Gln Gly Leu Gln Gly Thr Asn 
225                 230                 235                 240 


Gln Ser Phe His Pro Phe Ile His Arg His Lys Pro His Thr Gly Gln 
                245                 250                 255     


Val Trp Ala Ala Asp His Met Leu Glu Leu Leu Gln Gly Ser Gln Leu 
            260                 265                 270         


Ser Arg Asn Glu Leu Asp Gly Ser His Asp Tyr Arg Asp Gly Asp Leu 
        275                 280                 285             


Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro Gln Phe Leu Gly Pro 
    290                 295                 300                 


Ile Ile Asp Gly Met Ala Phe Ile Ser His His Leu Arg Val Glu Ile 
305                 310                 315                 320 


Asn Ser Ala Asn Asp Asn Pro Leu Ile Asp Thr Ala Ser Ala Ala Ser 
                325                 330                 335     


Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Ile Gly Val Gly Met Asp 
            340                 345                 350         


Gln Leu Arg Tyr Tyr Met Gly Leu Met Ala Lys His Leu Asp Val Gln 
        355                 360                 365             


Ile Ala Leu Leu Val Ser Pro Gln Phe Asn Asn Gly Leu Pro Ala Ser 
    370                 375                 380                 


Leu Val Gly Asn Ile Gln Arg Lys Val Asn Met Gly Leu Lys Gly Leu 
385                 390                 395                 400 


Gln Leu Thr Ala Asn Ser Ile Met Pro Ile Leu Thr Phe Leu Gly Asn 
                405                 410                 415     


Ser Leu Ala Asp Arg Phe Pro Thr His Ala Glu Gln Phe Asn Gln Asn 
            420                 425                 430         


Ile Asn Ser Gln Gly Phe Gly Ser Ala Asn Leu Ala Arg Gln Thr Ile 
        435                 440                 445             


Gln Thr Leu Gln Gln Tyr Ile Ala Ile Thr Leu Met Phe Gly Val Gln 
    450                 455                 460                 


Ala Val Asp Leu Arg Thr His Lys Leu Ala Gly His Tyr Asn Ala Ala 
465                 470                 475                 480 


Glu Leu Leu Ser Pro Leu Thr Ala Lys Ile Tyr His Ala Val Arg Ser 
                485                 490                 495     


Ile Val Lys His Pro Pro Ser Pro Glu Arg Pro Tyr Ile Trp Asn Asp 
            500                 505                 510         


Asp Glu Gln Val Leu Glu Ala His Ile Ser Ala Leu Ala His Asp Ile 
        515                 520                 525             


Ala Asn Asp Gly Ser Leu Val Ser Ala Val Glu Gln Thr Leu Ser Gly 
    530                 535                 540                 


Leu Arg Ser Ile Ile Leu Phe Arg 
545                 550         


<210>  9
<211>  552
<212>  PRT
<213>  Herpetosiphon aurantiacus

<400>  9

Met Arg His Gln Val Thr Leu Thr Gly Ala Gly Leu Thr Ile Glu Asp 
1               5                   10                  15      


Val Val Arg Val Ala Arg His His Gln Pro Val Gly Leu Thr Asp Asn 
            20                  25                  30          


Pro Glu Ile Leu Gln Arg Ile Glu Asp Ser Cys Ala Tyr Ile Asn Asp 
        35                  40                  45              


Ala Val Lys Ala Ser Lys Pro Val Tyr Gly Val Thr Thr Gly Phe Gly 
    50                  55                  60                  


Gly Met Ala Asp Val Val Ile Ser Ser Glu Glu Ala Ala Asp Leu Gln 
65                  70                  75                  80  


Asn Asn Ala Ile Trp Tyr His Lys Thr Gly Ala Gly Lys Leu Leu Pro 
                85                  90                  95      


Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg Ala Asn Ser His Met 
            100                 105                 110         


Arg Gly Val Ser Gly Ile Arg Leu Glu Ile Ile Gln Arg Met Met Thr 
        115                 120                 125             


Phe Leu Asn Ala Asn Val Thr Pro His Val Arg Glu Phe Gly Ser Ile 
    130                 135                 140                 


Gly Ala Ser Gly Asp Leu Val Pro Leu Ile Ser Ile Thr Gly Ala Leu 
145                 150                 155                 160 


Leu Gly Thr Asp Pro Ala Phe Arg Val Asp Phe Asp Gly Glu Asn Ile 
                165                 170                 175     


Asp Cys Leu Glu Ala Leu Glu Arg Leu Asn Leu Pro Arg Leu Glu Leu 
            180                 185                 190         


Leu Pro Lys Glu Gly Leu Ala Met Met Asn Gly Thr Ser Val Met Thr 
        195                 200                 205             


Gly Ile Ala Ser Asn Val Leu His Asp Ala Arg Ile Leu Leu Gly Leu 
    210                 215                 220                 


Ala Leu Asn Ile His Gly Leu Met Ile Gln Gly Leu Gln Gly Thr Asn 
225                 230                 235                 240 


Gln Ser Phe His Pro Phe Ile His Gln His Lys Ala His Thr Gly Gln 
                245                 250                 255     


Val Trp Ala Ala Asp His Met Leu Gln Ile Leu Glu Gly Ser Ala Leu 
            260                 265                 270         


Ser Arg Asp Glu Leu Asp Gly Arg His Glu Tyr Arg Glu Gly Asp Leu 
        275                 280                 285             


Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro Gln Phe Leu Gly Pro 
    290                 295                 300                 


Ile Ile Asp Gly Met Ala Tyr Ile Thr His His Leu Arg Val Glu Ile 
305                 310                 315                 320 


Asn Ser Ala Asn Asp Asn Pro Leu Ile Asn Thr Glu Ala Gly Ala Ser 
                325                 330                 335     


Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Ile Gly Val Gly Met Asp 
            340                 345                 350         


Gln Leu Arg Tyr Tyr Met Gly Leu Met Ala Lys His Leu Asp Val Gln 
        355                 360                 365             


Ile Ala Leu Leu Val Ser Pro Gln Phe Asn Asn Gly Leu Ser Ala Ser 
    370                 375                 380                 


Leu Val Gly Asn Thr Asp Arg Lys Val Asn Met Gly Leu Lys Gly Leu 
385                 390                 395                 400 


Gln Ile Ser Gly Asn Ser Ile Met Pro Ile Leu Gly Phe Leu Gly Asn 
                405                 410                 415     


Ser Leu Ala Asp Arg Phe Pro Thr His Ala Glu Gln Phe Asn Gln Asn 
            420                 425                 430         


Ile Asn Ser Gln Gly Phe Gly Ser Ala Asn Leu Ala Arg Gln Thr Ile 
        435                 440                 445             


Glu Thr Leu Gln Gln Tyr Ile Ala Ile Ala Leu Ile Phe Gly Val Gln 
    450                 455                 460                 


Ala Val Asp Leu Arg Thr Phe Lys Arg Thr Gly His Tyr Asn Ala Val 
465                 470                 475                 480 


Glu Thr Leu Ser Pro Met Thr Ala Lys Leu Tyr Ser Ala Met Arg Glu 
                485                 490                 495     


Val Val Gly Lys Pro Ile Ser His Glu Arg Pro Tyr Ile Trp Asn Asp 
            500                 505                 510         


Asn Glu Gln Ala Leu Glu Gln His Ile Ser Ala Ile Val Ser Asp Ile 
        515                 520                 525             


Thr Asn Asp Gly Ile Ile Pro Gln Ala Ile Gln Glu Thr Leu Asp Ser 
    530                 535                 540                 


Leu Arg Ser Ile Ile Leu Phe Ala 
545                 550         


<210>  10
<211>  523
<212>  PRT
<213>  Rhodobacter sphaeroides

<400>  10

Met Leu Ala Met Ser Pro Pro Lys Pro Ala Val Glu Leu Asp Arg His 
1               5                   10                  15      


Ile Asp Leu Asp Glu Ala His Ser Val Ala Ser Gly Gly Ala Arg Ile 
            20                  25                  30          


Val Leu Ala Pro Pro Ala Arg Asp Arg Cys Arg Ala Ser Glu Ala Arg 
        35                  40                  45              


Leu Gly Ala Val Ile Arg Glu Ala Arg His Val Tyr Gly Leu Thr Thr 
    50                  55                  60                  


Gly Phe Gly Pro Leu Ala Asn Arg Leu Val Ser Gly Glu Asn Val Arg 
65                  70                  75                  80  


Thr Leu Gln Ala Asn Leu Val His His Leu Ala Ser Gly Val Gly Pro 
                85                  90                  95      


Val Leu Asp Trp Thr Thr Ala Arg Ala Met Val Leu Ala Arg Leu Val 
            100                 105                 110         


Ala Ile Ala Gln Gly Ala Ser Gly Ala Ser Glu Gly Thr Ile Ala Arg 
        115                 120                 125             


Leu Ile Asp Leu Leu Asn Ser Glu Leu Ala Pro Ala Val Pro Met Arg 
    130                 135                 140                 


Gly Thr Val Gly Ala Ser Gly Asp Leu Thr Pro Leu Ala His Met Val 
145                 150                 155                 160 


Leu Cys Leu Gln Gly Arg Gly Asp Phe Leu Asp Arg Asp Gly Thr Arg 
                165                 170                 175     


Leu Asp Gly Ala Glu Gly Leu Arg Arg Gly Arg Leu Gln Pro Leu Asp 
            180                 185                 190         


Leu Ser His Arg Asp Ala Leu Ala Leu Val Asn Gly Thr Ser Ala Met 
        195                 200                 205             


Thr Gly Ile Ala Leu Val Asn Ala His Ala Cys Arg His Leu Gly Asn 
    210                 215                 220                 


Trp Ala Val Ala Leu Thr Ala Leu Leu Ala Glu Cys Leu Gly Gly Arg 
225                 230                 235                 240 


Thr Glu Ala Trp Ala Ala Ala Leu Ser Asp Leu Arg Pro His Pro Gly 
                245                 250                 255     


Gln Lys Asp Ala Ala Ala Arg Leu Arg Ala Arg Val Asp Gly Ser Ala 
            260                 265                 270         


Arg Val Val Arg His Val Ile Ala Glu Arg Arg Leu Gly Ala Ser Asp 
        275                 280                 285             


Ile Gly Thr Glu Pro Glu Ala Gly Gln Asp Ala Tyr Ser Leu Arg Cys 
    290                 295                 300                 


Ala Pro Gln Val Leu Gly Ala Gly Phe Asp Thr Leu Ala Trp His Asp 
305                 310                 315                 320 


Arg Val Leu Thr Ile Glu Leu Asn Ala Val Thr Asp Asn Pro Val Phe 
                325                 330                 335     


Pro Pro Asp Gly Ser Val Pro Ala Leu His Gly Gly Asn Phe Met Gly 
            340                 345                 350         


Gln His Val Ala Leu Thr Ser Asp Ala Leu Ala Thr Ala Val Thr Val 
        355                 360                 365             


Leu Ala Gly Leu Ala Glu Arg Gln Ile Ala Arg Leu Thr Asp Glu Arg 
    370                 375                 380                 


Leu Asn Arg Gly Leu Pro Pro Phe Leu His Arg Gly Pro Ala Gly Leu 
385                 390                 395                 400 


Asn Ser Gly Phe Met Gly Ala Gln Val Thr Ala Thr Ala Leu Leu Ala 
                405                 410                 415     


Glu Met Arg Ala Thr Gly Pro Ala Ser Ile His Ser Ile Ser Thr Asn 
            420                 425                 430         


Ala Ala Asn Gln Asp Val Val Ser Leu Gly Thr Ile Ala Ala Arg Leu 
        435                 440                 445             


Cys Arg Glu Lys Ile Asp Arg Trp Ala Glu Ile Leu Ala Ile Leu Ala 
    450                 455                 460                 


Leu Cys Leu Ala Gln Ala Ala Glu Leu Arg Cys Gly Ser Gly Leu Asp 
465                 470                 475                 480 


Gly Val Ser Pro Ala Gly Lys Lys Leu Val Gln Ala Leu Arg Glu Gln 
                485                 490                 495     


Phe Pro Pro Leu Glu Thr Asp Arg Pro Leu Gly Gln Glu Ile Ala Ala 
            500                 505                 510         


Leu Ala Thr His Leu Leu Gln Gln Ser Pro Val 
        515                 520             


<210>  11
<211>  510
<212>  PRT
<213>  Saccharothrix espanaensis

<400>  11

Met Thr Gln Val Val Glu Arg Gln Ala Asp Arg Leu Ser Ser Arg Glu 
1               5                   10                  15      


Tyr Leu Ala Arg Val Val Arg Ser Ala Gly Trp Asp Ala Gly Leu Thr 
            20                  25                  30          


Ser Cys Thr Asp Glu Glu Ile Val Arg Met Gly Ala Ser Ala Arg Thr 
        35                  40                  45              


Ile Glu Glu Tyr Leu Lys Ser Asp Lys Pro Ile Tyr Gly Leu Thr Gln 
    50                  55                  60                  


Gly Phe Gly Pro Leu Val Leu Phe Asp Ala Asp Ser Glu Leu Glu Gln 
65                  70                  75                  80  


Gly Gly Ser Leu Ile Ser His Leu Gly Thr Gly Gln Gly Ala Pro Leu 
                85                  90                  95      


Ala Pro Glu Val Ser Arg Leu Ile Leu Trp Leu Arg Ile Gln Asn Met 
            100                 105                 110         


Arg Lys Gly Tyr Ser Ala Val Ser Pro Val Phe Trp Gln Lys Leu Ala 
        115                 120                 125             


Asp Leu Trp Asn Lys Gly Phe Thr Pro Ala Ile Pro Arg His Gly Thr 
    130                 135                 140                 


Val Ser Ala Ser Gly Asp Leu Gln Pro Leu Ala His Ala Ala Leu Ala 
145                 150                 155                 160 


Phe Thr Gly Val Gly Glu Ala Trp Thr Arg Asp Ala Asp Gly Arg Trp 
                165                 170                 175     


Ser Thr Val Pro Ala Val Asp Ala Leu Ala Ala Leu Gly Ala Glu Pro 
            180                 185                 190         


Phe Asp Trp Pro Val Arg Glu Ala Leu Ala Phe Val Asn Gly Thr Gly 
        195                 200                 205             


Ala Ser Leu Ala Val Ala Val Leu Asn His Arg Ser Ala Leu Arg Leu 
    210                 215                 220                 


Val Arg Ala Cys Ala Val Leu Ser Ala Arg Leu Ala Thr Leu Leu Gly 
225                 230                 235                 240 


Ala Asn Pro Glu His Tyr Asp Val Gly His Gly Val Ala Arg Gly Gln 
                245                 250                 255     


Val Gly Gln Leu Thr Ala Ala Glu Trp Ile Arg Gln Gly Leu Pro Arg 
            260                 265                 270         


Gly Met Val Arg Asp Gly Ser Arg Pro Leu Gln Glu Pro Tyr Ser Leu 
        275                 280                 285             


Arg Cys Ala Pro Gln Val Leu Gly Ala Val Leu Asp Gln Leu Asp Gly 
    290                 295                 300                 


Ala Gly Asp Val Leu Ala Arg Glu Val Asp Gly Cys Gln Asp Asn Pro 
305                 310                 315                 320 


Ile Thr Tyr Glu Gly Glu Leu Leu His Gly Gly Asn Phe His Ala Met 
                325                 330                 335     


Pro Val Gly Phe Ala Ser Asp Gln Ile Gly Leu Ala Met His Met Ala 
            340                 345                 350         


Ala Tyr Leu Ala Glu Arg Gln Leu Gly Leu Leu Val Ser Pro Val Thr 
        355                 360                 365             


Asn Gly Asp Leu Pro Pro Met Leu Thr Pro Arg Ala Gly Arg Gly Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Gln Ile Ser Ala Thr Ser Phe Val Ser Arg Ile 
385                 390                 395                 400 


Arg Gln Leu Val Phe Pro Ala Ser Leu Thr Thr Leu Pro Thr Asn Gly 
                405                 410                 415     


Trp Asn Gln Asp His Val Pro Met Ala Leu Asn Gly Ala Asn Ser Val 
            420                 425                 430         


Phe Glu Ala Leu Glu Leu Gly Trp Leu Thr Val Gly Ser Leu Ala Val 
        435                 440                 445             


Gly Val Ala Gln Leu Ala Ala Met Thr Gly His Ala Ala Glu Gly Val 
    450                 455                 460                 


Trp Ala Glu Leu Ala Gly Ile Cys Pro Pro Leu Asp Ala Asp Arg Pro 
465                 470                 475                 480 


Leu Gly Ala Glu Val Arg Ala Ala Arg Asp Leu Leu Ser Ala His Ala 
                485                 490                 495     


Asp Gln Leu Leu Val Asp Glu Ala Asp Gly Lys Asp Phe Gly 
            500                 505                 510 


<210>  12
<211>  519
<212>  PRT
<213>  Rheinheimera sp. A13L

<400>  12

Met Arg Ser Glu Gln Leu Thr Leu Glu Asp Val Glu Ala Ile Ala Leu 
1               5                   10                  15      


Gly Arg Gln Thr Leu Val Val Thr Glu Lys Gln Met His Ala Val Glu 
            20                  25                  30          


Asn Ala His Lys Phe Leu Cys Arg Ala Ile Ser Asp Arg Lys Arg Ile 
        35                  40                  45              


Tyr Gly Val Thr Thr Gly Tyr Gly Pro Leu Ala Thr Thr Glu Val Asp 
    50                  55                  60                  


Pro Arg Gln Ser Ala Leu Leu Gln Gln Asn Leu Val His His Leu Cys 
65                  70                  75                  80  


Ser Gly Val Gly Asp Pro Leu Thr His Pro Gln Val Arg Ala Met Met 
                85                  90                  95      


Val Ala Arg Leu Ile Ser Leu Leu Ser Gly His Ser Gly Ala Asn Pro 
            100                 105                 110         


Leu Leu Ile Lys Arg Met Gln Glu Trp Leu Asp Ala Asp Ile Val Pro 
        115                 120                 125             


Phe Ile Pro Cys Arg Gly Thr Val Gly Ala Ser Gly Asp Leu Thr Pro 
    130                 135                 140                 


Leu Ala His Leu Ala Arg Ala Leu Ser Gly Gly Gly Lys Val Ser Ile 
145                 150                 155                 160 


Lys Gly Gly Leu Trp Ile Glu Ser Arg Asp Ala His Gln Gln Leu Gly 
                165                 170                 175     


Trp Gln Pro Leu Val Leu Lys Gly Lys Asp Ala Ile Ser Leu Val Asn 
            180                 185                 190         


Gly Thr Ser Ala Thr Val Gly Ile Ala Ala Leu Asn Ala Thr Ala Ala 
        195                 200                 205             


Glu Arg Ala Leu Lys Leu Ser Thr Leu Leu Val Leu Leu Tyr Ala Glu 
    210                 215                 220                 


Leu Leu Asn Gly His Arg Glu Ala Phe His Pro Ala Ile Gly Gln Leu 
225                 230                 235                 240 


Arg Pro His Pro Gly Gln Gln Lys Leu His Ser Trp Leu Trp Ser Leu 
                245                 250                 255     


Ser Ala Ser Ser Asp Ala Leu Val Pro Trp Cys Ala Glu Ser Arg Asn 
            260                 265                 270         


Leu Asn Leu Met Gly Glu Asp Ile Gln Gln Asn Gln Pro Leu Leu Gln 
        275                 280                 285             


Asp Ala Tyr Thr Leu Arg Cys Ala Pro Gln Ala Leu Gly Ala Ala Leu 
    290                 295                 300                 


Asp Val Ile Ser Gln His Ala Thr Thr Val Lys Ile Glu Leu Ser Ala 
305                 310                 315                 320 


Val Thr Asp Asn Pro Leu Leu Phe Ala Glu Asp Glu Leu Ile Leu His 
                325                 330                 335     


Gly Gly Asn Phe Phe Gly Gln His Leu Ala Phe Ala Ser Asp His Leu 
            340                 345                 350         


Asn Asn Ala Leu Ile Gln Met Ala Leu Tyr Ser Glu Arg Arg Ile Ala 
        355                 360                 365             


Arg Ile Thr Asp Pro Leu Arg Asn Lys Gly Leu Pro Ala Phe Met Gln 
    370                 375                 380                 


Pro Leu Asp Thr Gly Leu His Ser Gly Phe Met Gly Ala Gln Val Cys 
385                 390                 395                 400 


Ala Thr Ser Leu Val Ala Glu Leu Arg Ser Gln Ala Met Pro Ala Ser 
                405                 410                 415     


Ile Gln Ser Ile Pro Thr Asn Ala Asp Asn Gln Asp Ile Val Pro Leu 
            420                 425                 430         


Gly Thr Ile Ala Ala Arg Arg Ala Ser Thr Ser Leu Thr Gln Leu Tyr 
        435                 440                 445             


Gln Ile Leu Ala Ile Glu Ala Leu Val Leu Val Gln Gly Ala Glu Leu 
    450                 455                 460                 


Lys Asn Thr His Ser Phe Ser His Ser Ser Gln Val Val Cys Ala Trp 
465                 470                 475                 480 


Leu Arg Gln Tyr Ala Leu Pro Leu Lys Glu Asp Arg Ala Leu Ser Glu 
                485                 490                 495     


Asp Ile Thr Arg Val Ala Glu Ala Leu Ile Asp Pro Asp Lys Val Lys 
            500                 505                 510         


Ser Leu Ile Glu Leu Leu Ala 
        515                 


<210>  13
<211>  713
<212>  PRT
<213>  Rhodotorula mucilaginosa

<400>  13

Met Ala Pro Ser Val Asp Ser Ile Ala Thr Ser Val Ala Asn Ser Leu 
1               5                   10                  15      


Ser Asn Gly Leu His Ala Ala Ala Ala Ala Asn Gly Gly Asp Val His 
            20                  25                  30          


Lys Lys Thr Ala Gly Ala Gly Ser Leu Leu Pro Thr Thr Glu Thr Thr 
        35                  40                  45              


Gln Leu Asp Ile Val Glu Arg Ile Leu Ala Asp Ala Gly Ala Thr Asp 
    50                  55                  60                  


Gln Ile Lys Leu Asp Gly Tyr Thr Leu Thr Leu Gly Asp Val Val Gly 
65                  70                  75                  80  


Ala Ala Arg Arg Gly Arg Ser Val Lys Val Ala Asp Ser Pro His Ile 
                85                  90                  95      


Arg Glu Lys Ile Asp Ala Ser Val Glu Phe Leu Arg Thr Gln Leu Asp 
            100                 105                 110         


Asn Ser Val Tyr Gly Val Thr Thr Gly Phe Gly Gly Ser Ala Asp Thr 
        115                 120                 125             


Arg Thr Glu Asp Ala Ile Ser Leu Gln Lys Ala Leu Leu Glu His Gln 
    130                 135                 140                 


Leu Cys Gly Val Leu Pro Thr Ser Met Asp Gly Phe Ala Leu Gly Arg 
145                 150                 155                 160 


Gly Leu Glu Asn Ser Leu Pro Leu Glu Val Val Arg Gly Ala Met Thr 
                165                 170                 175     


Ile Arg Val Asn Ser Leu Thr Arg Gly His Ser Ala Val Arg Ile Val 
            180                 185                 190         


Val Leu Glu Ala Leu Thr Asn Phe Leu Asn His Gly Ile Thr Pro Ile 
        195                 200                 205             


Val Pro Leu Arg Gly Thr Ile Ser Ala Ser Gly Asp Leu Ser Pro Leu 
    210                 215                 220                 


Ser Tyr Ile Ala Ala Ser Ile Thr Gly His Pro Asp Ser Lys Val His 
225                 230                 235                 240 


Val Asp Gly Lys Ile Met Ser Ala Gln Glu Ala Ile Ala Leu Lys Gly 
                245                 250                 255     


Leu Gln Pro Val Val Leu Gly Pro Lys Glu Gly Leu Gly Leu Val Asn 
            260                 265                 270         


Gly Thr Ala Val Ser Ala Ser Met Ala Thr Leu Ala Leu Thr Asp Ala 
        275                 280                 285             


His Val Leu Ser Leu Leu Ala Gln Ala Leu Thr Ala Leu Thr Val Glu 
    290                 295                 300                 


Ala Met Val Gly His Ala Gly Ser Phe His Pro Phe Leu His Asp Val 
305                 310                 315                 320 


Thr Arg Pro His Pro Thr Gln Ile Glu Val Ala Arg Asn Ile Arg Thr 
                325                 330                 335     


Leu Leu Glu Gly Ser Lys Tyr Ala Val His His Glu Thr Glu Val Lys 
            340                 345                 350         


Val Lys Asp Asp Glu Gly Ile Leu Arg Gln Asp Arg Tyr Pro Leu Arg 
        355                 360                 365             


Cys Ser Pro Gln Trp Leu Gly Pro Leu Val Ser Asp Met Ile His Ala 
    370                 375                 380                 


His Ala Val Leu Ser Leu Glu Ala Gly Gln Ser Thr Thr Asp Asn Pro 
385                 390                 395                 400 


Leu Ile Asp Leu Glu Asn Lys Met Thr His His Gly Gly Ala Phe Met 
                405                 410                 415     


Ala Ser Ser Val Gly Asn Thr Met Glu Lys Thr Arg Leu Ala Val Ala 
            420                 425                 430         


Leu Met Gly Lys Val Ser Phe Thr Gln Leu Thr Glu Met Leu Asn Ala 
        435                 440                 445             


Gly Met Asn Arg Ala Leu Pro Ser Cys Leu Ala Ala Glu Asp Pro Ser 
    450                 455                 460                 


Leu Ser Tyr His Cys Lys Gly Leu Asp Ile Ala Ala Ala Ala Tyr Thr 
465                 470                 475                 480 


Ser Glu Leu Gly His Leu Ala Asn Pro Val Ser Thr His Val Gln Pro 
                485                 490                 495     


Ala Glu Met Gly Asn Gln Ala Ile Asn Ser Leu Ala Leu Ile Ser Ala 
            500                 505                 510         


Arg Arg Thr Ala Glu Ala Asn Asp Val Leu Ser Leu Leu Leu Ala Thr 
        515                 520                 525             


His Leu Tyr Cys Val Leu Gln Ala Val Asp Leu Arg Ala Met Glu Phe 
    530                 535                 540                 


Glu His Thr Lys Ala Phe Glu Pro Met Val Thr Glu Leu Leu Lys Gln 
545                 550                 555                 560 


His Phe Gly Ala Leu Ala Thr Ala Glu Val Glu Asp Lys Val Arg Lys 
                565                 570                 575     


Ser Ile Tyr Lys Arg Leu Gln Gln Asn Asn Ser Tyr Asp Leu Glu Gln 
            580                 585                 590         


Arg Trp His Asp Thr Phe Ser Val Ala Thr Gly Ala Val Val Glu Ala 
        595                 600                 605             


Leu Ala Gly Gln Glu Val Ser Leu Ala Ser Leu Asn Ala Trp Lys Val 
    610                 615                 620                 


Ala Cys Ala Glu Lys Ala Ile Ala Leu Thr Arg Ser Val Arg Asp Ser 
625                 630                 635                 640 


Phe Trp Ala Ala Pro Ser Ser Ser Ser Pro Ala Leu Lys Tyr Leu Ser 
                645                 650                 655     


Pro Arg Thr Arg Val Leu Tyr Ser Phe Val Arg Glu Glu Val Gly Val 
            660                 665                 670         


Lys Ala Arg Arg Gly Asp Val Tyr Leu Gly Lys Gln Glu Val Thr Ile 
        675                 680                 685             


Gly Thr Asn Val Ser Arg Ile Tyr Glu Ala Ile Lys Ser Gly Cys Ile 
    690                 695                 700                 


Ala Pro Val Leu Val Lys Met Met Ala 
705                 710             


<210>  14
<211>  689
<212>  PRT
<213>  Trichosporon cutaneum

<400>  14

Met Phe Ile Glu Thr Asn Val Ala Lys Pro Ala Ser Thr Lys Ala Met 
1               5                   10                  15      


Asn Ala Gly Ser Ala Lys Ala Ala Pro Val Glu Pro Phe Ala Thr Tyr 
            20                  25                  30          


Ala His Ser Gln Ala Thr Lys Thr Val Ser Ile Asp Gly His Thr Met 
        35                  40                  45              


Lys Val Gly Asp Val Val Ala Val Ala Arg His Gly Ala Lys Val Glu 
    50                  55                  60                  


Leu Ala Ala Ser Val Ala Gly Pro Val Arg Ala Ser Val Asp Phe Lys 
65                  70                  75                  80  


Glu Ser Lys Lys His Thr Ser Ile Tyr Gly Val Thr Thr Gly Phe Gly 
                85                  90                  95      


Gly Ser Ala Asp Thr Arg Thr Ser Asp Thr Glu Ala Leu Gln Ile Ser 
            100                 105                 110         


Leu Leu Glu His Gln Leu Cys Gly Phe Leu Pro Thr Asp Ala Thr Tyr 
        115                 120                 125             


Glu Gly Met Leu Leu Ala Ala Met Pro Ile Pro Ile Val Arg Gly Ala 
    130                 135                 140                 


Met Ala Val Arg Val Asn Ser Cys Val Arg Gly His Ser Gly Val Arg 
145                 150                 155                 160 


Leu Glu Val Leu Gln Ser Phe Ala Asp Phe Ile Asn Arg Gly Leu Val 
                165                 170                 175     


Pro Cys Val Pro Leu Arg Gly Thr Ile Ser Ala Ser Gly Asp Leu Ser 
            180                 185                 190         


Pro Leu Ser Tyr Ile Ala Gly Ala Ile Cys Gly His Pro Asp Val Lys 
        195                 200                 205             


Val Phe Asp Thr Ala Ala Ser Pro Pro Thr Val Leu Thr Ser Pro Glu 
    210                 215                 220                 


Ala Ile Ala Lys Tyr Gly Leu Lys Thr Val Lys Leu Ala Ser Lys Glu 
225                 230                 235                 240 


Gly Leu Gly Leu Val Asn Gly Thr Ala Val Ser Ala Ala Ala Gly Ala 
                245                 250                 255     


Leu Ala Leu Tyr Asp Ala Glu Cys Leu Ala Ile Met Ser Gln Thr Asn 
            260                 265                 270         


Thr Val Leu Thr Val Glu Ala Leu Asp Gly His Val Gly Ser Phe Ala 
        275                 280                 285             


Pro Phe Ile Gln Glu Ile Arg Pro His Ala Gly Gln Ile Glu Ala Ala 
    290                 295                 300                 


Arg Asn Ile Arg His Met Leu Gly Gly Ser Lys Leu Ala Val His Glu 
305                 310                 315                 320 


Glu Ser Glu Leu Leu Ala Asp Gln Asp Ala Gly Ile Leu Arg Gln Asp 
                325                 330                 335     


Arg Tyr Ala Leu Arg Thr Ser Ala Gln Trp Ile Gly Pro Gln Leu Glu 
            340                 345                 350         


Ala Leu Gly Leu Ala Arg Gln Gln Ile Glu Thr Glu Leu Asn Ser Thr 
        355                 360                 365             


Thr Asp Asn Pro Leu Ile Asp Val Glu Gly Gly Met Phe His His Gly 
    370                 375                 380                 


Gly Asn Phe Gln Ala Met Ala Val Thr Ser Ala Met Asp Ser Ala Arg 
385                 390                 395                 400 


Ile Val Leu Gln Asn Leu Gly Lys Leu Ser Phe Ala Gln Val Thr Glu 
                405                 410                 415     


Leu Ile Asn Cys Glu Met Asn His Gly Leu Pro Ser Asn Leu Ala Gly 
            420                 425                 430         


Ser Glu Pro Ser Thr Asn Tyr His Cys Lys Gly Leu Asp Ile His Cys 
        435                 440                 445             


Gly Ala Tyr Cys Ala Glu Leu Gly Phe Leu Ala Asn Pro Met Ser Asn 
    450                 455                 460                 


His Val Gln Ser Thr Glu Met His Asn Gln Ser Val Asn Ser Met Ala 
465                 470                 475                 480 


Phe Ala Ser Ala Arg Arg Thr Met Glu Ala Asn Glu Val Leu Ser Leu 
                485                 490                 495     


Leu Leu Gly Ser Gln Met Tyr Cys Ala Thr Gln Ala Leu Asp Leu Arg 
            500                 505                 510         


Val Met Glu Val Lys Phe Lys Met Ala Ile Val Lys Leu Leu Asn Glu 
        515                 520                 525             


Thr Leu Thr Lys His Phe Ala Ala Phe Leu Thr Pro Glu Gln Leu Ala 
    530                 535                 540                 


Lys Leu Asn Thr His Ala Ala Ile Thr Leu Tyr Lys Arg Leu Asn Gln 
545                 550                 555                 560 


Thr Pro Ser Trp Asp Ser Ala Pro Arg Phe Glu Asp Ala Ala Lys His 
                565                 570                 575     


Leu Val Gly Val Ile Met Asp Ala Leu Met Val Asn Asp Asp Ile Thr 
            580                 585                 590         


Asp Leu Thr Asn Leu Pro Lys Trp Lys Lys Glu Phe Ala Lys Glu Ala 
        595                 600                 605             


Gly Asn Leu Tyr Arg Ser Ile Leu Val Ala Thr Thr Ala Asp Gly Arg 
    610                 615                 620                 


Asn Asp Leu Glu Pro Ala Glu Tyr Leu Gly Gln Thr Arg Ala Val Tyr 
625                 630                 635                 640 


Glu Ala Val Arg Ser Glu Leu Gly Val Lys Val Arg Arg Gly Asp Val 
                645                 650                 655     


Ala Glu Gly Lys Ser Gly Lys Ser Ile Gly Ser Ser Val Ala Lys Ile 
            660                 665                 670         


Val Glu Ala Met Arg Asp Gly Arg Leu Met Gly Ala Val Gly Lys Met 
        675                 680                 685             


Phe 
    


<210>  15
<211>  716
<212>  PRT
<213>  Rhodosporidium toruloides

<400>  15

Met Ala Pro Ser Leu Asp Ser Ile Ser His Ser Phe Ala Asn Gly Val 
1               5                   10                  15      


Ala Ser Ala Lys Gln Ala Val Asn Gly Ala Ser Thr Asn Leu Ala Val 
            20                  25                  30          


Ala Gly Ser His Leu Pro Thr Thr Gln Val Thr Gln Val Asp Ile Val 
        35                  40                  45              


Glu Lys Met Leu Ala Ala Pro Thr Asp Ser Thr Leu Glu Leu Asp Gly 
    50                  55                  60                  


Tyr Ser Leu Asn Leu Gly Asp Val Val Ser Ala Ala Arg Lys Gly Arg 
65                  70                  75                  80  


Pro Val Arg Val Lys Asp Ser Asp Glu Ile Arg Ser Lys Ile Asp Lys 
                85                  90                  95      


Ser Val Glu Phe Leu Arg Ser Gln Leu Ser Met Ser Val Tyr Gly Val 
            100                 105                 110         


Thr Thr Gly Phe Gly Gly Ser Ala Asp Thr Arg Thr Glu Asp Ala Ile 
        115                 120                 125             


Ser Leu Gln Lys Ala Leu Leu Glu His Gln Leu Cys Gly Val Leu Pro 
    130                 135                 140                 


Ser Ser Phe Asp Ser Phe Arg Leu Gly Arg Gly Leu Glu Asn Ser Leu 
145                 150                 155                 160 


Pro Leu Glu Val Val Arg Gly Ala Met Thr Ile Arg Val Asn Ser Leu 
                165                 170                 175     


Thr Arg Gly His Ser Ala Val Arg Leu Val Val Leu Glu Ala Leu Thr 
            180                 185                 190         


Asn Phe Leu Asn His Gly Ile Thr Pro Ile Val Pro Leu Arg Gly Thr 
        195                 200                 205             


Ile Ser Ala Ser Gly Asp Leu Ser Pro Leu Ser Tyr Ile Ala Ala Ala 
    210                 215                 220                 


Ile Ser Gly His Pro Asp Ser Lys Val His Val Val His Glu Gly Lys 
225                 230                 235                 240 


Glu Lys Ile Leu Tyr Ala Arg Glu Ala Met Ala Leu Phe Asn Leu Glu 
                245                 250                 255     


Pro Val Val Leu Gly Pro Lys Glu Gly Leu Gly Leu Val Asn Gly Thr 
            260                 265                 270         


Ala Val Ser Ala Ser Met Ala Thr Leu Ala Leu His Asp Ala His Met 
        275                 280                 285             


Leu Ser Leu Leu Ser Gln Ser Leu Thr Ala Met Thr Val Glu Ala Met 
    290                 295                 300                 


Val Gly His Ala Gly Ser Phe His Pro Phe Leu His Asp Val Thr Arg 
305                 310                 315                 320 


Pro His Pro Thr Gln Ile Glu Val Ala Gly Asn Ile Arg Lys Leu Leu 
                325                 330                 335     


Glu Gly Ser Arg Phe Ala Val His His Glu Glu Glu Val Lys Val Lys 
            340                 345                 350         


Asp Asp Glu Gly Ile Leu Arg Gln Asp Arg Tyr Pro Leu Arg Thr Ser 
        355                 360                 365             


Pro Gln Trp Leu Gly Pro Leu Val Ser Asp Leu Ile His Ala His Ala 
    370                 375                 380                 


Val Leu Thr Ile Glu Ala Gly Gln Ser Thr Thr Asp Asn Pro Leu Ile 
385                 390                 395                 400 


Asp Val Glu Asn Lys Thr Ser His His Gly Gly Asn Phe Gln Ala Ala 
                405                 410                 415     


Ala Val Ala Asn Thr Met Glu Lys Thr Arg Leu Gly Leu Ala Gln Ile 
            420                 425                 430         


Gly Lys Leu Asn Phe Thr Gln Leu Thr Glu Met Leu Asn Ala Gly Met 
        435                 440                 445             


Asn Arg Gly Leu Pro Ser Cys Leu Ala Ala Glu Asp Pro Ser Leu Ser 
    450                 455                 460                 


Tyr His Cys Lys Gly Leu Asp Ile Ala Ala Ala Ala Tyr Thr Ser Glu 
465                 470                 475                 480 


Leu Gly His Leu Ala Asn Pro Val Thr Thr His Val Gln Pro Ala Glu 
                485                 490                 495     


Met Ala Asn Gln Ala Val Asn Ser Leu Ala Leu Ile Ser Ala Arg Arg 
            500                 505                 510         


Thr Thr Glu Ser Asn Asp Val Leu Ser Leu Leu Leu Ala Thr His Leu 
        515                 520                 525             


Tyr Cys Val Leu Gln Ala Ile Asp Leu Arg Ala Ile Glu Phe Glu Phe 
    530                 535                 540                 


Lys Lys Gln Phe Gly Pro Ala Ile Val Ser Leu Ile Asp Gln His Phe 
545                 550                 555                 560 


Gly Ser Ala Met Thr Gly Ser Asn Leu Arg Asp Glu Leu Val Glu Lys 
                565                 570                 575     


Val Asn Lys Thr Leu Ala Lys Arg Leu Glu Gln Thr Asn Ser Tyr Asp 
            580                 585                 590         


Leu Val Pro Arg Trp His Asp Ala Phe Ser Phe Ala Ala Gly Thr Val 
        595                 600                 605             


Val Glu Val Leu Ser Ser Thr Ser Leu Ser Leu Ala Ala Val Asn Ala 
    610                 615                 620                 


Trp Lys Val Ala Ala Ala Glu Ser Ala Ile Ser Leu Thr Arg Gln Val 
625                 630                 635                 640 


Arg Glu Thr Phe Trp Ser Ala Ala Ser Thr Ser Ser Pro Ala Leu Ser 
                645                 650                 655     


Tyr Leu Ser Pro Arg Thr Gln Ile Leu Tyr Ala Phe Val Arg Glu Glu 
            660                 665                 670         


Leu Gly Val Lys Ala Arg Arg Gly Asp Val Phe Leu Gly Lys Gln Glu 
        675                 680                 685             


Val Thr Ile Gly Ser Asn Val Ser Lys Ile Tyr Glu Ala Ile Lys Ser 
    690                 695                 700                 


Gly Arg Ile Asn Asn Val Leu Leu Lys Met Leu Ala 
705                 710                 715     


<210>  16
<211>  737
<212>  PRT
<213>  Phanerochaete chrysosporium

<400>  16

Met Pro Ser Arg Ile Asp Tyr Tyr Thr Ser Ser Gly Asn Gly Tyr Ala 
1               5                   10                  15      


Gln Ser Arg Lys Ser Ser Ala Ile Tyr Pro Ala Ser Ala Ser Thr Gly 
            20                  25                  30          


His Ala Ala Pro Ser Thr Glu Arg Lys Pro Glu Leu Leu Asp Lys Phe 
        35                  40                  45              


Val Glu Ala Tyr Asp Glu Leu Gln Ser Tyr Arg Glu Gly Lys Pro Val 
    50                  55                  60                  


Ile Val Asp Gly His Asn Leu Ser Ile Pro Ala Val Ala Ala Thr Ala 
65                  70                  75                  80  


Arg Phe Gly Ala Ala Val Val Leu Asp Glu Asn Pro Glu Thr His Glu 
                85                  90                  95      


Arg Val Leu Gln Ser Arg Arg Val Ile Val Asp Lys Val Ser Thr Gln 
            100                 105                 110         


Arg Ser Val Tyr Gly Val Ser Thr Gly Phe Gly Gly Ser Ala Asp Thr 
        115                 120                 125             


Arg Thr Ser Asp Pro Leu Gln Leu Gly His Ala Leu Leu Gln His Gln 
    130                 135                 140                 


His Val Gly Val Leu Pro Thr Gln Thr Glu Ser Pro Leu Pro Ala Leu 
145                 150                 155                 160 


Pro Leu Gly Asp Pro Leu Ala Thr Thr Ser Met Pro Glu Ala Trp Val 
                165                 170                 175     


Arg Gly Ala Ile Leu Ile Arg Met Asn Ser Leu Ile Arg Gly His Ser 
            180                 185                 190         


Gly Val Arg Trp Glu Leu Ile Glu Lys Met Gly Glu Leu Leu Arg Glu 
        195                 200                 205             


Asn Ile Thr Pro Leu Val Pro Leu Arg Gly Ser Ile Ser Ala Ser Gly 
    210                 215                 220                 


Asp Leu Ser Pro Leu Ser Tyr Ile Ala Gly Thr Leu Ile Gly Ser Pro 
225                 230                 235                 240 


Ala Ile Arg Val Phe Asp Gly Pro Ala Ser Tyr Gly Ala Arg Arg Ile 
                245                 250                 255     


Leu Pro Ser Asn Ile Ala Leu Ala Asn His Gly Val Ala Pro Ile Pro 
            260                 265                 270         


Leu Ser Ser Lys Glu His Leu Gly Ile Leu Asn Gly Thr Ala Phe Ser 
        275                 280                 285             


Ala Ser Val Gly Ala Leu Ala Leu Asn Glu Ala Val His Leu Ser Leu 
    290                 295                 300                 


Leu Ala Gln Val Cys Thr Ala Met Gly Thr Glu Ala Met Ile Gly Ala 
305                 310                 315                 320 


Val Gly Ser Phe Asp Ala Phe Ile His Asp Thr Ala Arg Pro His Pro 
                325                 330                 335     


Gly Gln Val Glu Val Ala Arg Asn Val Arg Thr Leu Leu Glu Asp Ser 
            340                 345                 350         


Gln Met Ala Val Lys Ala Glu Asp Glu Val His Ile Ala Glu Asp Glu 
        355                 360                 365             


Gly Glu Leu Arg Gln Asp Arg Tyr Pro Leu Arg Thr Ala Ala Gln Phe 
    370                 375                 380                 


Leu Gly Pro Gln Ile Glu Asp Ile Leu Ser Ala His Glu Thr Val Thr 
385                 390                 395                 400 


Leu Glu Cys Asn Ser Thr Thr Asp Asn Pro Leu Ile Asp Gly Glu Thr 
                405                 410                 415     


Gly Thr Val His His Gly Gly Asn Phe Gln Ala Met Ala Val Thr Asn 
            420                 425                 430         


Ala Met Glu Lys Thr Arg Leu Ala Ile His His Ile Gly Lys Leu Leu 
        435                 440                 445             


Phe Ala Gln Ala Thr Glu Leu Ile Asn Pro Met Met Asn Arg Gly Leu 
    450                 455                 460                 


Pro Pro Asn Leu Ala Ala Thr Asp Pro Ser His Asn Tyr Phe Ala Lys 
465                 470                 475                 480 


Gly Val Asp Ile His Leu Ala Ala Tyr Val Gly Glu Leu Gly Phe Leu 
                485                 490                 495     


Ala Ser Pro Val Ser Ser His Ile Gln Ser Ala Glu Met His Asn Gln 
            500                 505                 510         


Ala Val Asn Ser Leu Ala Leu Val Ser Ala Arg Tyr Thr Ile Ser Ala 
        515                 520                 525             


Leu Asp Val Leu Ser Leu Leu Thr Ala Ala Tyr Leu Tyr Val Leu Cys 
    530                 535                 540                 


Gln Ala Leu Asp Leu Arg Ala Met His Asn Asp Leu Gln Ser Ser Leu 
545                 550                 555                 560 


Ser Ala Ile Val Arg Glu Leu Leu Pro Lys His Phe Pro Ser Ala Ala 
                565                 570                 575     


Lys Arg Ala Asp Ala Leu Leu Pro Ile Leu Glu Arg Thr Ile Phe Arg 
            580                 585                 590         


Ala Leu Asn Ser Ser Ser Ser Ala Asp Cys Lys Ala Arg Met Val Ser 
        595                 600                 605             


Val Ala Ala Ser Thr Thr Thr Pro Leu Val Asp Phe Leu Ser Ala Asp 
    610                 615                 620                 


Ala Ala Leu Ala Ser Glu Leu Ala Asn Ile Thr Ala Phe Arg Thr Glu 
625                 630                 635                 640 


Leu Ala Thr Arg Ala Ala Asp Ala Leu Thr Thr Leu Arg Thr Gln Tyr 
                645                 650                 655     


Leu Glu Gly Ala Arg Gly Ala Ala Pro Ala Ser Lys Tyr Leu Gly Lys 
            660                 665                 670         


Thr Arg Pro Val Tyr Glu Phe Val Arg Val Thr Leu Asn Val Pro Met 
        675                 680                 685             


His Gly Arg Glu Asn Leu His Asn Phe Glu Met Gly Pro Gly Val Glu 
    690                 695                 700                 


Asp Gly Ile Ile Gly Asn Asn Ile Ser Thr Ile Tyr Glu Ala Ile Arg 
705                 710                 715                 720 


Asp Gly Lys Met Gln Asn Val Val Met Gln Leu Val Lys Ser Ile Lys 
                725                 730                 735     


Ala 
    


<210>  17
<211>  540
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  17

Met Leu Asp Ala Thr Ile Gly Arg Lys Arg Met Thr Leu Gln Ser Gln 
1               5                   10                  15      


Thr Ala Lys Asp Cys Leu Ala Leu Asp Gly Ala Leu Thr Leu Val Gln 
            20                  25                  30          


Cys Glu Ala Ile Ala Thr His Arg Ser Arg Ile Ser Val Thr Pro Ala 
        35                  40                  45              


Leu Arg Glu Arg Cys Ala Arg Ala His Ala Arg Leu Glu His Ala Ile 
    50                  55                  60                  


Ala Glu Gln Arg His Ile Tyr Gly Ile Thr Thr Gly Phe Gly Pro Leu 
65                  70                  75                  80  


Ala Asn Arg Leu Ile Gly Ala Asp Gln Gly Ala Glu Leu Gln Gln Asn 
                85                  90                  95      


Leu Ile Tyr His Leu Ala Thr Gly Val Gly Pro Lys Leu Ser Trp Ala 
            100                 105                 110         


Glu Ala Arg Ala Leu Met Leu Ala Arg Leu Asn Ser Ile Leu Gln Gly 
        115                 120                 125             


Ala Ser Gly Ala Ser Pro Glu Thr Ile Asp Arg Ile Val Ala Val Leu 
    130                 135                 140                 


Asn Ala Gly Phe Ala Pro Glu Val Pro Ala Gln Gly Thr Val Gly Ala 
145                 150                 155                 160 


Ser Gly Asp Leu Thr Pro Leu Ala His Met Val Leu Ala Leu Gln Gly 
                165                 170                 175     


Arg Gly Arg Met Ile Asp Pro Ser Gly Arg Val Gln Glu Ala Gly Ala 
            180                 185                 190         


Val Met Asp Arg Leu Cys Gly Gly Pro Leu Thr Leu Ala Ala Arg Asp 
        195                 200                 205             


Gly Leu Ala Leu Val Asn Gly Thr Ser Ala Met Thr Ala Ile Ala Ala 
    210                 215                 220                 


Leu Thr Gly Val Glu Ala Ala Arg Ala Ile Asp Ala Ala Leu Arg His 
225                 230                 235                 240 


Ser Ala Val Leu Met Glu Val Leu Ser Gly His Ala Glu Ala Trp His 
                245                 250                 255     


Pro Ala Phe Ala Glu Leu Arg Pro His Pro Gly Gln Leu Arg Ala Thr 
            260                 265                 270         


Glu Arg Leu Ala Gln Ala Leu Asp Gly Ala Gly Arg Val Cys Arg Thr 
        275                 280                 285             


Leu Thr Ala Ala Arg Arg Leu Thr Ala Ala Asp Leu Arg Pro Glu Asp 
    290                 295                 300                 


His Pro Ala Gln Asp Ala Tyr Ser Leu Arg Val Val Pro Gln Leu Val 
305                 310                 315                 320 


Gly Ala Val Trp Asp Thr Leu Asp Trp His Asp Arg Val Val Thr Cys 
                325                 330                 335     


Glu Leu Asn Ser Val Thr Asp Asn Pro Ile Phe Pro Glu Gly Cys Ala 
            340                 345                 350         


Val Pro Ala Leu His Gly Gly Asn Phe Met Gly Val His Val Ala Leu 
        355                 360                 365             


Ala Ser Asp Ala Leu Asn Ala Ala Leu Val Thr Leu Ala Gly Leu Val 
    370                 375                 380                 


Glu Arg Gln Ile Ala Arg Leu Thr Asp Glu Lys Leu Asn Lys Gly Leu 
385                 390                 395                 400 


Pro Ala Phe Leu His Gly Gly Gln Ala Gly Leu Gln Ser Gly Phe Met 
                405                 410                 415     


Gly Ala Gln Val Thr Ala Thr Ala Leu Leu Ala Glu Met Arg Ala Asn 
            420                 425                 430         


Ala Thr Pro Val Ser Val Gln Ser Leu Ser Thr Asn Gly Ala Asn Gln 
        435                 440                 445             


Asp Val Val Ser Met Gly Thr Ile Ala Ala Arg Arg Ala Arg Ala Gln 
    450                 455                 460                 


Leu Leu Pro Leu Ser Gln Ile Gln Ala Ile Leu Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Gln Ala Met Asp Leu Leu Asp Asp Pro Glu Gly Gln Ala Gly Trp Ser 
                485                 490                 495     


Leu Thr Ala Arg Asp Leu Arg Asp Arg Ile Arg Ala Val Ser Pro Gly 
            500                 505                 510         


Leu Arg Ala Asp Arg Pro Leu Ala Gly Asp Ile Glu Ala Val Ala Gln 
        515                 520                 525             


Gly Leu Arg His Pro Ser Ala Ala Asp Pro Pro Ala 
    530                 535                 540 


<210>  18
<211>  291
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Glu Phe Ser Arg Pro Pro Leu Val His Val Lys Gly Ile Pro Leu 
1               5                   10                  15      


Ile Lys Tyr Phe Ala Glu Thr Ile Gly Pro Leu Gln Asn Phe Thr Ala 
            20                  25                  30          


Trp Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys Ser Gly Thr Thr 
        35                  40                  45              


Trp Met Ser Glu Ile Leu Asp Met Ile Tyr Gln Gly Gly Lys Leu Glu 
    50                  55                  60                  


Lys Cys Gly Arg Ala Pro Ile Tyr Ala Arg Val Pro Phe Leu Glu Phe 
65                  70                  75                  80  


Lys Cys Pro Gly Val Pro Ser Gly Leu Glu Thr Leu Glu Glu Thr Pro 
                85                  90                  95      


Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser Leu Leu Pro Gln 
            100                 105                 110         


Ser Leu Leu Asp Gln Lys Val Lys Val Ile Tyr Ile Ala Arg Asn Ala 
        115                 120                 125             


Lys Asp Val Val Val Ser Tyr Tyr Asn Phe Tyr Asn Met Ala Lys Leu 
    130                 135                 140                 


His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu Asn Phe Met Asp 
145                 150                 155                 160 


Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val Lys Glu Trp Trp 
                165                 170                 175     


Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe Tyr Glu Asp Ile 
            180                 185                 190         


Lys Glu Asn Pro Lys Arg Glu Ile Lys Lys Ile Leu Glu Phe Leu Gly 
        195                 200                 205             


Arg Ser Leu Pro Glu Glu Thr Val Asp Ser Ile Val His His Thr Ser 
    210                 215                 220                 


Phe Lys Lys Met Lys Glu Asn Cys Met Thr Asn Tyr Thr Thr Ile Pro 
225                 230                 235                 240 


Thr Glu Ile Met Asp His Asn Val Ser Pro Phe Met Arg Lys Gly Thr 
                245                 250                 255     


Thr Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln Asn Glu Arg Phe 
            260                 265                 270         


Asp Ala His Tyr Ala Lys Thr Met Thr Asp Cys Asp Phe Lys Phe Arg 
        275                 280                 285             


Cys Glu Leu 
    290     


<210>  19
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
    130                 135                 140                 


Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Met Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210>  20
<211>  295
<212>  PRT
<213>  Equus caballus

<400>  20

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Lys Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Glu Ile Leu Asp Met Ile Tyr His Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys Arg Arg Ala Pro Ile Phe Ile Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Ala Pro Glu Ile Pro Ser Gly Val Glu Val Leu 
                85                  90                  95      


Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Leu 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr Arg 
    130                 135                 140                 


Met Ala Lys Val His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Lys His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser His Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Lys Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Leu Asp Arg Ile Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Ala Asn Tyr 
225                 230                 235                 240 


Ser Thr Ile Pro Cys Asp Ile Met Asp His Asn Ile Ser Ala Phe Met 
                245                 250                 255     


Arg Lys Gly Ile Ala Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu His Phe Asp Thr Asp Tyr Ala Glu Lys Met Ala Gly Cys Lys 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Val 
    290                 295 


<210>  21
<211>  295
<212>  PRT
<213>  Sus scrofa

<400>  21

Met Glu Pro Val Gln Asp Thr Tyr Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Glu 
            20                  25                  30          


Ser Phe Gln Ala Trp Pro Asp Asp Val Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Glu Ile Leu Asp Leu Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Gln Lys Cys Gln Arg Ala Pro Ile Phe Val Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Ile Pro Gly Cys Pro Thr Gly Phe Glu Leu Leu 
                85                  90                  95      


Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr Arg 
    130                 135                 140                 


Met Ala Lys Val His Pro Asn Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Asp Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Glu Asp Ile Val 
    210                 215                 220                 


Gln His Thr Ser Phe Gln Glu Met Lys Asn Asn Ala Met Thr Asn Tyr 
225                 230                 235                 240 


Arg Thr Leu Pro Ser Asp Leu Leu Asp His Ser Ile Ser Ala Phe Met 
                245                 250                 255     


Arg Lys Gly Ile Thr Gly Asp Trp Lys Ser Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Glu Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Asn 
        275                 280                 285             


Leu Arg Phe Arg Ser Glu Leu 
    290                 295 


<210>  22
<211>  295
<212>  PRT
<213>  Canis lupus

<400>  22

Met Glu Asp Ile Pro Asp Thr Ser Arg Pro Pro Leu Lys Tyr Val Lys 
1               5                   10                  15      


Gly Ile Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Glu Ser Leu Gln 
            20                  25                  30          


Asp Phe Gln Ala Gln Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Glu Ile Leu Asp Met Ile Tyr Gln Asp 
    50                  55                  60                  


Gly Asp Val Glu Lys Cys Arg Arg Ala Pro Val Phe Ile Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Thr Gly Leu Glu Val Leu 
                85                  90                  95      


Lys Asp Thr Pro Ala Pro Arg Leu Ile Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr Arg 
    130                 135                 140                 


Met Ala Lys Val His Pro Asp Pro Asp Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser His Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Lys Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Leu Ile Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Asn Asn Ser Met Ala Asn Tyr 
225                 230                 235                 240 


Thr Thr Leu Ser Pro Asp Ile Met Asp His Ser Ile Ser Ala Phe Met 
                245                 250                 255     


Arg Lys Gly Ile Ser Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Lys Lys Met Glu Gly Cys Gly 
        275                 280                 285             


Leu Ser Phe Arg Thr Gln Leu 
    290                 295 


<210>  23
<211>  294
<212>  PRT
<213>  Gallus gallus

<400>  23

Met Gly Asn Asp Glu Val Ile Arg Gln Asp Leu Gly Cys Leu Tyr Asp 
1               5                   10                  15      


Ile Pro Leu Tyr Lys Cys Phe Val Ala Gly Trp Pro Gln Val Glu Ala 
            20                  25                  30          


Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ala Thr Tyr Pro Lys Ser 
        35                  40                  45              


Gly Thr Thr Trp Leu Ser Glu Ile Leu Asp Ala Ile Tyr His Asp Gly 
    50                  55                  60                  


Asp Leu Glu Lys Cys Arg Arg Asp Ala Ile Tyr Asn Arg Val Pro Phe 
65                  70                  75                  80  


Leu Glu Met Lys Ala Pro Gly Ile Leu Ser Gly Val Glu Gln Leu Glu 
                85                  90                  95      


Lys Ile Pro Ser Pro Arg Leu Val Lys Thr His Leu Pro Val His Leu 
            100                 105                 110         


Leu Pro Ala Ser Phe Gln Glu Lys Asp Cys Lys Val Ile Tyr Met Ala 
        115                 120                 125             


Arg Asn Ala Lys Asp Val Val Ile Ser Tyr Tyr Tyr Phe Tyr Gln Met 
    130                 135                 140                 


Ala Lys Ile His Pro Asp Pro Gly Thr Leu Ser Glu Phe Leu Gln Ala 
145                 150                 155                 160 


Phe Met Asp Gly Lys Val Ala Tyr Gly Ser Trp Tyr Lys His Val Lys 
                165                 170                 175     


Gly Trp Trp Glu Lys Arg His Glu Lys Arg Leu Leu Tyr Leu Phe Tyr 
            180                 185                 190         


Glu Asp Met Lys Lys Asp Pro Arg Arg Glu Ile Gln Lys Ile Leu Gln 
        195                 200                 205             


Phe Leu Gly Lys Glu Val Ala Glu Glu Thr Val Ala Arg Ile Leu His 
    210                 215                 220                 


His Thr Ser Phe Gln Glu Met Lys Lys Asn Pro Ala Thr Asn Tyr Glu 
225                 230                 235                 240 


Thr Met Pro Thr Glu Leu Met Asp His Ser Leu Ser Pro Phe Met Arg 
                245                 250                 255     


Lys Gly Ile Ser Gly Asp Trp Ala Asn His Phe Thr Val Ala Gln Asn 
            260                 265                 270         


Glu Arg Phe Asp Gln His Tyr Gln Gln Gln Met Ala Gly Ser Asp Leu 
        275                 280                 285             


Cys Phe Gln Met Glu Ala 
    290                 


<210>  24
<211>  307
<212>  PRT
<213>  Gallus gallus

<400>  24

Met Ala Leu Asp Lys Met Glu Asn Leu Ser Leu Glu Glu Asn Met Leu 
1               5                   10                  15      


Arg Ser Glu Met Gly Glu Val Gln Gly Ile Pro Val Thr Lys Pro Thr 
            20                  25                  30          


Cys Asp Ile Trp Asp Gln Val Trp Asn Phe Lys Ala Arg Pro Asp Asp 
        35                  40                  45              


Leu Leu Val Ala Thr Tyr Ala Lys Ala Gly Thr Thr Trp Thr Gln Glu 
    50                  55                  60                  


Ile Val Asp Met Ile Gln Gln Asn Gly Asp Ile Glu Lys Cys Arg Arg 
65                  70                  75                  80  


Ala Ser Thr Tyr Lys Arg His Pro Phe Leu Glu Trp Tyr Ile Pro Asp 
                85                  90                  95      


Ser Ser Pro Leu Gly Tyr Ser Gly Leu Lys Leu Ala Glu Ala Met Pro 
            100                 105                 110         


Ser Pro Arg Thr Met Lys Thr His Leu Pro Val Gln Leu Val Pro Pro 
        115                 120                 125             


Ser Phe Trp Glu Gln Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Ala 
    130                 135                 140                 


Lys Asp Asn Leu Val Ser Tyr Tyr His Phe His Arg Met Asn Lys Val 
145                 150                 155                 160 


Leu Pro Asp Pro Gly Thr Ile Glu Glu Phe Thr Glu Lys Phe Met Asn 
                165                 170                 175     


Gly Glu Val Leu Trp Gly Ser Trp Tyr Asp His Val Lys Gly Trp Trp 
            180                 185                 190         


Lys Ala Lys Asp Lys His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met 
        195                 200                 205             


Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Met Lys Phe Leu Glu 
    210                 215                 220                 


Lys Asp Leu Asp Glu Glu Val Leu Asn Lys Ile Ile Tyr Asn Thr Ser 
225                 230                 235                 240 


Phe Glu Ile Met Lys Asp Asn Pro Met Thr Asn Tyr Thr Lys Asp Phe 
                245                 250                 255     


Val Gly Val Met Asp His Ser Val Ser Pro Phe Met Arg Lys Gly Ser 
            260                 265                 270         


Val Gly Asp Trp Lys Asn Tyr Phe Thr Val Ala Leu Asn Lys Lys Phe 
        275                 280                 285             


Asp Gln Asp Tyr Lys Lys Lys Met Ala Asp Thr Ser Leu Val Phe Arg 
    290                 295                 300                 


Met Glu Leu 
305         


<210>  25
<211>  301
<212>  PRT
<213>  Danio rerio

<400>  25

Met Asp Leu Pro Asp Ile Ser Ser Ile Lys Leu Pro Ser Arg Pro Lys 
1               5                   10                  15      


Ile Phe Glu Phe Glu Gly Ile Ser Met Ile Ser Tyr Phe Thr Asp Asn 
            20                  25                  30          


Trp Glu Lys Leu Lys Asn Phe Gln Ala Arg Pro Asp Asp Ile Leu Ile 
        35                  40                  45              


Ala Thr Tyr Pro Lys Ala Gly Thr Thr Trp Val Ser Tyr Ile Leu Asp 
    50                  55                  60                  


Leu Leu Tyr Phe Gly Lys Val Glu Pro Asn Gly Gln Ser Ser Leu Pro 
65                  70                  75                  80  


Ile Tyr Met Arg Val Pro Phe Leu Glu Ser Cys Phe Pro Gly Met Pro 
                85                  90                  95      


Ser Gly Thr Glu Leu Ala Asp Asn Leu Pro Asn Ser Pro Arg Leu Ile 
            100                 105                 110         


Lys Thr His Leu Pro Val Gln Leu Val Pro Lys Ser Phe Trp Gly Gln 
        115                 120                 125             


Asn Ser Lys Val Val Tyr Val Ala Arg Asn Ala Lys Asp Asn Val Val 
    130                 135                 140                 


Ser Phe Phe His Phe Asp Arg Met Asn His Gly Gln Pro Glu Pro Gly 
145                 150                 155                 160 


Asp Trp Asp Thr Phe Leu Gln Ala Phe Ile Lys Gly Glu Arg Val Phe 
                165                 170                 175     


Gly Ser Trp Phe Asp His Val Cys Gly Trp Trp Glu Lys Lys Lys Thr 
            180                 185                 190         


Tyr Pro Asn Leu His Tyr Met Phe Tyr Glu Asp Ile Ala Lys Asp Ile 
        195                 200                 205             


Asn Gly Glu Val Glu Ser Leu Cys Thr Phe Leu Lys Leu Ser Arg Ser 
    210                 215                 220                 


Asp Glu Glu Lys Glu Lys Ile Ile Asn Gly Val Gln Phe Asp Ala Met 
225                 230                 235                 240 


Lys Gln Asn Val Met Thr Asn Tyr Ser Thr Ile Pro Thr Met Asp Phe 
                245                 250                 255     


Thr Ile Ser Pro Phe Met Arg Lys Gly Lys Val Gly Asp Trp Lys Asn 
            260                 265                 270         


His Phe Thr Val Ala Gln Asn Glu Gln Phe Asp Glu Asp Tyr Lys Glu 
        275                 280                 285             


Lys Met Lys Asn Thr Thr Leu Asn Phe Arg Thr Lys Ile 
    290                 295                 300     


<210>  26
<211>  300
<212>  PRT
<213>  Danio rerio

<400>  26

Met Glu Ile Gln Gly Lys Ser Ser Thr Asp Leu Pro Asp Arg Pro Glu 
1               5                   10                  15      


Ile Phe Glu Phe Glu Gly Ile Ser Met Val Glu His Phe Thr Lys Asn 
            20                  25                  30          


Trp Glu Asn Val Lys Asn Phe Gln Ala Arg Pro Asp Asp Ile Leu Ile 
        35                  40                  45              


Ala Thr Tyr Pro Lys Ala Gly Thr Thr Trp Val Ser Asn Ile Leu Asp 
    50                  55                  60                  


Leu Leu Tyr Phe Gly Lys Glu Asp Pro Lys Arg Gln Thr Thr Lys Pro 
65                  70                  75                  80  


Ile Tyr Lys Arg Val Pro Phe Leu Glu Ser Cys Phe Pro Glu Met Gln 
                85                  90                  95      


Ser Gly Thr Glu Leu Ala Asn Asn Leu Pro Thr Ser Pro Arg Leu Ile 
            100                 105                 110         


Lys Thr His Leu Pro Val Gln Leu Val Pro Gln Ser Phe Trp Glu Lys 
        115                 120                 125             


Asn Ser Arg Val Ala Tyr Val Ala Arg Asn Ala Lys Asp Asn Ala Val 
    130                 135                 140                 


Ser Tyr Phe His Phe Asn Arg Met Asn Lys Ala Gln Pro Glu Pro Gly 
145                 150                 155                 160 


Asp Trp Asn Thr Phe Leu Glu Glu Phe Met Lys Gly Lys Met Val Phe 
                165                 170                 175     


Gly Ser Trp Phe Asp His Val Cys Gly Trp Trp Glu Lys Lys Lys Thr 
            180                 185                 190         


Tyr Pro Asn Leu His Tyr Met Leu Tyr Glu Asp Met Ala Lys Asp Ile 
        195                 200                 205             


Lys Gly Glu Val Glu Ser Leu Cys Thr Phe Leu Lys Leu Ser Arg Ser 
    210                 215                 220                 


Asp Glu Glu Lys Glu Lys Ile Ile Asn Gly Ile Gln Phe Asp Ala Met 
225                 230                 235                 240 


Lys Gln Asn Lys Met Thr Asn Tyr Ser Thr Val Leu Val Met Asp Phe 
                245                 250                 255     


Thr Ile Ser Pro Phe Met Arg Lys Gly Lys Val Gly Asp Trp Lys Asn 
            260                 265                 270         


His Phe Thr Val Ala Gln Asn Glu Gln Phe Asn Glu Asp Tyr Lys Gln 
        275                 280                 285             


Lys Met Lys Asn Ser Thr Leu Lys Phe Pro Thr Glu 
    290                 295                 300 


<210>  27
<211>  338
<212>  PRT
<213>  Drosophila melanogaster

<400>  27

Met Pro Gln Ser Ser Phe Phe Ala Lys Ser Val Pro Phe Glu Gln Ile 
1               5                   10                  15      


Asp Lys Leu Ala Ile Ser Gly Gly Tyr Ser Ser Ile Phe Ala Ser Ser 
            20                  25                  30          


Lys Pro Ser Val Pro Val Val Gly Asn Trp Glu Gln Arg Phe Cys Arg 
        35                  40                  45              


Leu Ala Asp Thr Phe Gln Pro Val Leu Asp Arg Val Tyr Asp Phe Glu 
    50                  55                  60                  


Val Arg Asp Asp Asp Val Trp Ile Val Thr Leu Pro Lys Cys Gly Thr 
65                  70                  75                  80  


Thr Trp Met Gln Glu Leu Ala Trp Leu Val Ile Asn Glu Cys Asp Phe 
                85                  90                  95      


Glu Thr Ala Lys Ser Val Asp Leu Thr His Arg Ser Pro Phe Leu Glu 
            100                 105                 110         


Phe Asn Gly Val Val Pro Asn Val Pro His Asp Thr Ile Ala Ala Ala 
        115                 120                 125             


Asn Ala Leu Pro Ser Pro Arg Leu Ile Lys Ser His Leu Pro Ala Trp 
    130                 135                 140                 


Met Leu Pro Arg Gln Ile Trp Ser Lys Arg Pro Lys Ile Ile Tyr Val 
145                 150                 155                 160 


Tyr Arg Asn Pro Lys Asp Ala Ala Ile Ser Tyr Phe His His Trp Arg 
                165                 170                 175     


Gly Met Val Gly Tyr Gln Gly Thr Lys Ser Asp Phe Met His Ser Phe 
            180                 185                 190         


Ile Asp Gly Tyr Val Asn Phe Thr Pro Cys Trp Pro His Ile Leu Asp 
        195                 200                 205             


Phe Trp Gln Leu Arg His Glu Pro Asn Ile Phe Phe Thr Ser Tyr Glu 
    210                 215                 220                 


Arg Met Lys Gly Gln Leu Gly Gln Val Ile Ser Glu Val Ala Gln Phe 
225                 230                 235                 240 


Leu Glu Arg Ser Val Ser Gln Glu Gln Met Gln Gln Met Gln Arg His 
                245                 250                 255     


Leu Ser Phe Glu Ser Met Arg Asp Asn Pro Ala Cys Asn His Val Lys 
            260                 265                 270         


Glu Phe Glu Ser Met Lys Ala Ala Ala Gly Arg Glu Val Glu Glu Phe 
        275                 280                 285             


Arg Phe Val Arg Arg Gly Val Val Gly Ser His Lys Asp Glu Leu Thr 
    290                 295                 300                 


Ala Asp Ile Ile Arg Glu Phe Asp Leu Trp Ser Asp Ser Asn Leu Arg 
305                 310                 315                 320 


Asp Phe Lys Leu Asn Met Asp Asp Phe Ala Asn Tyr Ser Lys Phe Ala 
                325                 330                 335     


Ser Thr 
        


<210>  28
<211>  313
<212>  PRT
<213>  Drosophila melanogaster

<400>  28

Met Asn Arg Val Gln Val Thr Pro Arg Ser Tyr Pro Thr Asn Leu Ile 
1               5                   10                  15      


Asp Lys Asp Trp Gly Asn Arg Lys Leu Phe Tyr Thr Lys Asp Ser Glu 
            20                  25                  30          


Asn Phe Leu Arg Leu Val His Asp Met Lys Leu Arg Asp Asp Asp Val 
        35                  40                  45              


Trp Ile Val Thr Leu Pro Lys Cys Gly Thr Thr Trp Met Gln Glu Leu 
    50                  55                  60                  


Leu Trp Leu Leu Leu Asn Asn Cys Asp Phe Glu Gly Ala Leu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Leu Arg Thr Pro Phe Leu Glu Phe Gly Tyr Ser Val Phe 
                85                  90                  95      


His Asp Pro Asn Arg Ser Phe Gly Pro Ile Glu Asp Leu Lys Ser Pro 
            100                 105                 110         


Arg Leu Ile Lys Ser His Leu Ser Leu Ala Leu Leu Pro Ser Lys Leu 
        115                 120                 125             


Trp Glu Gly Lys Asn Lys Val Ile Tyr Val Ser Arg Asn Pro Leu Asp 
    130                 135                 140                 


Ser Tyr Val Ser Arg Tyr Tyr His Gly Val Ser Phe Gly Phe Asn Tyr 
145                 150                 155                 160 


Gly Lys Ser Leu His Gln Tyr Phe Asp Glu Val Leu Ala Ser Asp Asp 
                165                 170                 175     


Phe Pro Thr Glu Phe Ile Glu His Ala His Glu Phe Tyr Gln Leu Arg 
            180                 185                 190         


Asn Glu Pro Trp Val Phe Tyr Thr Ser Phe Glu Met Met Lys Lys Asp 
        195                 200                 205             


Leu Arg Gly Val Ile Asn Asp Val Ser Arg Phe Leu Asn Lys Pro Ile 
    210                 215                 220                 


Asn Asp Gln Gln Met Glu Lys Leu Leu Lys His Leu Ser Phe Ala Glu 
225                 230                 235                 240 


Met Lys Lys Asn Pro Thr Thr Asn His Leu Trp Glu Leu Ala Gln Val 
                245                 250                 255     


Gln His Glu Asn Ala Gly Lys Glu Met His Pro Phe Val Arg Arg Gly 
            260                 265                 270         


Asp Val Asn Gly Tyr Lys Asp Glu Leu Lys Pro Glu Gln Ile Glu Lys 
        275                 280                 285             


Ala Asn Val Arg Ile Gln Glu Val Leu Ala Lys Asn Gly Val Thr Leu 
    290                 295                 300                 


Asp Glu Leu Leu Leu Leu Lys Asp Gln 
305                 310             


<210>  29
<211>  346
<212>  PRT
<213>  Drosophila melanogaster

<400>  29

Met Glu Asn Thr Pro Leu Lys Phe Pro His Glu Ile Arg Asp Val Glu 
1               5                   10                  15      


Glu Ser Thr Asn Ala Glu Leu Leu Asp His Phe His Gly Glu Arg Thr 
            20                  25                  30          


Gly Phe Val Gln Val Gly Ser Glu Gly Tyr Phe Phe Pro His Lys Tyr 
        35                  40                  45              


Lys Asp Glu Ala Glu Arg Tyr Tyr Asn Phe Glu Ala Arg Pro Asp Asp 
    50                  55                  60                  


Val Trp Ile Ala Thr Val Pro Arg Ser Gly Thr Thr Trp Thr Gln Glu 
65                  70                  75                  80  


Leu Ile Trp Leu Val Ala Asn Gly Leu Asp Phe Glu His Ala Gln Glu 
                85                  90                  95      


Arg Pro Leu Thr Glu Arg Phe Pro Phe Phe Glu Phe Pro Leu Phe Val 
            100                 105                 110         


His Pro Lys Ile Lys Glu Glu Leu Gln Glu Glu Asn Arg Asp Ser Ala 
        115                 120                 125             


Glu Ala Leu Glu Phe Ile Glu Lys Ile Ala Arg Pro Gly Tyr Glu Ala 
    130                 135                 140                 


Leu Ser Glu Ile Pro Arg Ser Gln Arg Arg Phe Ile Lys Thr His Phe 
145                 150                 155                 160 


Pro Phe Ser Leu Met Pro Pro Ser Val Leu Glu Lys Lys Cys Lys Val 
                165                 170                 175     


Ile Tyr Val Val Arg Asp Pro Lys Asp Val Ala Val Ser Tyr Tyr His 
            180                 185                 190         


Leu Asn Arg Leu Phe Arg Thr Gln Gly Tyr Val Gly Asp Phe Glu Arg 
        195                 200                 205             


Tyr Trp His Tyr Phe Gln Asn Gly Leu Asn Pro Trp Leu Pro Tyr Tyr 
    210                 215                 220                 


Ser His Val Lys Glu Ala Arg Glu His Ala His Leu Ser Asn Val Leu 
225                 230                 235                 240 


Phe Leu Arg Tyr Glu Asp Met Leu Ala Asp Leu Pro Gly Ala Ile Asn 
                245                 250                 255     


Ser Ile Ala Ser Phe Leu Glu Cys Pro Pro Lys Pro Glu Asp Met Asp 
            260                 265                 270         


Arg Leu Leu Asp His Leu Ser Ile Arg Ser Phe Arg Glu Asn Lys Ser 
        275                 280                 285             


Val Asn Met His Glu Met Ala Ser Val Gly Val Leu Asn Lys Gly Glu 
    290                 295                 300                 


Ala Gly Phe Val Arg Ser Gly Ala Lys Thr Ala Tyr Gln Pro Gln Gln 
305                 310                 315                 320 


Glu Phe Val Glu Asn Pro Lys Leu Leu Lys Ser Ala Asn Glu Trp Val 
                325                 330                 335     


Glu Gln Asn Ile Lys Ser Phe Lys Thr Ile 
            340                 345     


<210>  30
<211>  323
<212>  PRT
<213>  Arabidopsis thaliana

<400>  30

Met Glu Met Asn Leu Arg Ile Glu Asp Leu Asn Glu Glu Thr Lys Thr 
1               5                   10                  15      


Leu Ile Ser Ser Leu Pro Ser Asp Lys Asp Phe Thr Gly Lys Thr Ile 
            20                  25                  30          


Cys Lys Tyr Gln Gly Cys Trp Tyr Thr His Asn Val Leu Gln Ala Val 
        35                  40                  45              


Leu Asn Phe Gln Lys Ser Phe Lys Pro Gln Asp Thr Asp Ile Ile Val 
    50                  55                  60                  


Ala Ser Phe Pro Lys Cys Gly Thr Thr Trp Leu Lys Ala Leu Thr Phe 
65                  70                  75                  80  


Ala Leu Leu His Arg Ser Lys Gln Pro Ser His Asp Asp Asp His Pro 
                85                  90                  95      


Leu Leu Ser Asn Asn Pro His Val Leu Val Pro Tyr Phe Glu Ile Asp 
            100                 105                 110         


Leu Tyr Leu Arg Ser Glu Asn Pro Asp Leu Thr Lys Phe Ser Ser Ser 
        115                 120                 125             


Pro Arg Leu Phe Ser Thr His Val Pro Ser His Thr Leu Gln Glu Gly 
    130                 135                 140                 


Leu Lys Gly Ser Thr Cys Lys Ile Val Tyr Ile Ser Arg Asn Val Lys 
145                 150                 155                 160 


Asp Thr Leu Val Ser Tyr Trp His Phe Phe Thr Lys Lys Gln Thr Asp 
                165                 170                 175     


Glu Lys Ile Ile Ser Ser Phe Glu Asp Thr Phe Glu Met Phe Cys Arg 
            180                 185                 190         


Gly Val Ser Ile Phe Gly Pro Phe Trp Asp His Val Leu Ser Tyr Trp 
        195                 200                 205             


Arg Gly Ser Leu Glu Asp Pro Asn His Val Leu Phe Met Lys Phe Glu 
    210                 215                 220                 


Glu Met Lys Ala Glu Pro Arg Asp Gln Ile Lys Lys Phe Ala Glu Phe 
225                 230                 235                 240 


Leu Gly Cys Pro Phe Thr Lys Glu Glu Glu Glu Ser Gly Ser Val Asp 
                245                 250                 255     


Glu Ile Ile Asp Leu Cys Ser Leu Arg Asn Leu Ser Ser Leu Glu Ile 
            260                 265                 270         


Asn Lys Thr Gly Lys Leu Asn Ser Gly Arg Glu Asn Lys Met Phe Phe 
        275                 280                 285             


Arg Lys Gly Glu Val Gly Asp Trp Lys Asn Tyr Leu Thr Pro Glu Met 
    290                 295                 300                 


Glu Asn Lys Ile Asp Met Ile Ile Gln Glu Lys Leu Gln Asn Ser Gly 
305                 310                 315                 320 


Leu Lys Phe 
            


<210>  31
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA body sequence

<400>  31
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  32
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purF (E. coli)

<400>  32
tcataaatcg actggttaac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  33
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purD (E. coli)

<400>  33
cggcgactgg gccgctttcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  34
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purN (E. coli)

<400>  34
ctgtaaatta cttccgttgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  35
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purL (E. coli)

<400>  35
attcggaatg ccgacagtgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  36
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purM (E. coli)

<400>  36
ggcatctttg tagctaagag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  37
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purK (E. coli)

<400>  37
ggcctaactg cccgttaccg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  38
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purE (E. coli)

<400>  38
gacacgcgcc ggattattgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  39
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purC (E. coli)

<400>  39
attcgagcac caacaggtcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  40
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purB (E. coli)

<400>  40
tccatcgaca ggggaaacgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  41
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purH (E. coli)

<400>  41
aaacactgag cagagcgcgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  42
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purA (E. coli)

<400>  42
tttaccttcg tcaccccatt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  43
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting guaA (E. coli)

<400>  43
gagaaccgaa gtccagaatg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  44
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting guaB (E. coli)

<400>  44
cggtagagtg agcaggaacg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  45
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting adk (E. coli)

<400>  45
tgagtccctt tccccgcgcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  46
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting gmk (E. coli)

<400>  46
tggatttacc cgcgccactg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  47
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pykA (E. coli)

<400>  47
atctgttgct gggcctaacg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  48
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting guaC (E. coli)

<400>  48
taagagtgga gcgtttaggg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  49
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting dgt (E. coli)

<400>  49
ttttaacgcc ctgcggtgaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  50
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting carA (E. coli)

<400>  50
tatggcccga ccgtgaaact gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  51
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting carB (E. coli)

<400>  51
tcgggcccgc acccagaatc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  52
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrB (E. coli)

<400>  52
atgatatgtt tctgatatag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  53
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrC (E. coli)

<400>  53
cggatcttta atacctggga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  54
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrD (E. coli)

<400>  54
aaaagggctt tacgaacgaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  55
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrE (E. coli)

<400>  55
taagcgcaaa ttcaataaac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  56
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrF (E. coli)

<400>  56
caggagaatt cgtaacagcg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  57
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrG (E. coli)

<400>  57
ggcaatgcct ttacccagag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  58
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrH (E. coli)

<400>  58
tttatagacg ggttttgcat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  59
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting ndk (E. coli)

<400>  59
acgttttttg ctaccgcgtt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  60
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting cmk (E. coli)

<400>  60
ggccatcaat ggtaataacc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  61
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting nrdA (E. coli)

<400>  61
gtgggagcgc agctcgacct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  62
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting nrdB (E. coli)

<400>  62
atttttcgtc tgtgaaaagg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  63
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting nrdD (E. coli)

<400>  63
ccgtctcgtt tcatcacatg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  64
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting tmk (E. coli)

<400>  64
ctcaaccacc acattacgcg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  65
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting dut (E. coli)

<400>  65
gaaattcctt cccaacgcgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  66
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting thyA (E. coli)

<400>  66
aatggaaagc gttccggttc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  67
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting dcd (E. coli)

<400>  67
caagccaggc ttcaatatct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  68
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting cdd (E. coli)

<400>  68
atccgcaagt tgggcaaaag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  69
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting codA (E. coli)

<400>  69
cccctcttcg cctggtaacc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  70
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting udk (E. coli)

<400>  70
caattcacga taaagggtac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  71
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting tdk (E. coli)

<400>  71
cagtgcgcat gccgcgttcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  72
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting udp (E. coli)

<400>  72
gagatgaaaa acatcagact gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  73
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting deoA (E. coli)

<400>  73
gaaaatggtc atcgcgaggg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  74
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpB (E. coli)

<400>  74
tggtgtccta tgtaatcctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  75
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpF (E. coli)

<400>  75
acaggacaaa cgcgatggcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  76
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpE (E. coli)

<400>  76
tgtacagcag atccatattc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  77
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpD (E. coli)

<400>  77
agggaattcg acgtcaacta gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  78
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpG (E. coli)

<400>  78
tagtgatctt ttgcgtgttc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  79
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpA (E. coli)

<400>  79
gatcagttcg ctgatttcgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  80
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpH (E. coli)

<400>  80
caaaagctgc tttggcgtag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  81
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting atpC (E. coli)

<400>  81
gctctgcgct gacgacgtcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  82
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  82
aatggaaagc gttccggttc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  83
aggagaattc gtaacagcgc                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  84
ctgccaaagc gaaagtgaca                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  85
gatcattaac tgtgaatgat                                                   20


<210>  86
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting thyA (E. coli)

<400>  86
aatggaaagc gttccggttc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  87
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrF (E. coli)

<400>  87
aggagaattc gtaacagcgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  88
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting dnaA (E. coli)

<400>  88
ctgccaaagc gaaagtgaca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  89
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting oriC (E. coli)

<400>  89
gatcattaac tgtgaatgat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  90
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nc (blank)

<400>  90
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  91
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
catctaattc aacaagaatt gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  92
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
aattcttgtt gaattagatg actagtatta tacctaggac tgagctagc                   49


<210>  93
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
aatggaaagc gttccggttc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  94
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
gaaccggaac gctttccatt actagtatta tacctaggac tgagctagc                   49


<210>  95
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
aggagaattc gtaacagcgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  96
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
gcgctgttac gaattctcct actagtatta tacctaggac tgagctagc                   49


<210>  97
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
gttttagagc tagaaatagc aagttaaaat aaggc                                  35


<210>  98
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  98
gctatttcta gctctaaaac actagtatta tacctaggac tgagctagc                   49


<210>  99
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
gctatttcta gctctaaaac actagtcttt tctctatcac tgataggga                   49


<210>  100
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
actttaataa ggagatatac ggttacggtt gagtaataaa tgga                        44


<210>  101
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
tggcagcagc ctaggttaat cgaaccgaac aggcttatgt c                           41


<210>  102
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
agatgcaugg cgcctaac                                                     18


<210>  103
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
agccctcuag aggatccccg ggta                                              24


<210>  104
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
agagggcuca acgtctcatt ttcgccag                                          28


<210>  105
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
atgcatcuat ccttactcga gttagtcacc                                        30


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106
agtcggugct ttttttgaag                                                   20


<210>  107
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
accgacuact agtcttttct ctatcactg                                         29


<210>  108
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
ctccctatca gtgatagaga aaagact                                           27


<210>  109
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  109
cgggcccaag cttcaaaaaa agcaccgact cggtgccact ttttcaagtt gataacggac       60


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  110
agtcggtgct ttttttgaag                                                   20


<210>  111
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  111
actagtcttt tctctatcac tgatagggag                                        30


<210>  112
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  112
acttcaatta acaccagcgg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  113
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  113
ccgctggtgt taattgaagt actagtcttt tctctatcac tgataggga                   49


<210>  114
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  114
agacgcgtta gtgtcttatc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  115
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  115
gataagacac taacgcgtct actagtcttt tctctatcac tgataggga                   49


<210>  116
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  116
agctcttcct caatgttgac gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  117
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  117
gtcaacattg aggaagagct actagtcttt tctctatcac tgataggga                   49


<210>  118
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  118
attacctttt gtgaaggcag gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  119
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  119
ctgccttcac aaaaggtaat actagtcttt tctctatcac tgataggga                   49


<210>  120
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  120
cgtcagggtg actttcttgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  121
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  121
gcaagaaagt caccctgacg actagtcttt tctctatcac tgataggga                   49


<210>  122
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  122
cgtcgcggtt cagacatgaa gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  123
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  123
ttcatgtctg aaccgcgacg actagtcttt tctctatcac tgataggga                   49


<210>  124
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  124
gagaagcaga tgacttccgg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  125
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  125
ccggaagtca tctgcttctc actagtcttt tctctatcac tgataggga                   49


<210>  126
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  126
gttgaatgtc cagaacgggt gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  127
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  127
acccgttctg gacattcaac actagtcttt tctctatcac tgataggga                   49


<210>  128
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  128
taaactgtgg cggataggat gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  129
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  129
atcctatccg ccacagttta actagtcttt tctctatcac tgataggga                   49


<210>  130
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  130
tactaagact accagggcgg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  131
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  131
ccgccctggt agtcttagta actagtcttt tctctatcac tgataggga                   49


<210>  132
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  132
aatcctgcgc ctgacaggcc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  133
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  133
ggcctgtcag gcgcaggatt actagtcttt tctctatcac tgataggga                   49


<210>  134
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  134
ataggtaaat ttctgggtcc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  135
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  135
ggacccagaa atttacctat actagtcttt tctctatcac tgataggga                   49


<210>  136
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  136
cggcatatac atttgggtcc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  137
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  137
ggacccaaat gtatatgccg actagtcttt tctctatcac tgataggga                   49


<210>  138
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  138
cttcggttat tgccgggtcc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  139
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  139
ggacccggca ataaccgaag actagtcttt tctctatcac tgataggga                   49


<210>  140
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  140
tgtttaacaa atgggggcac gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  141
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  141
gtgcccccat ttgttaaaca actagtcttt tctctatcac tgataggga                   49


<210>  142
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  142
tcgtcggcag cgtcagatgt gtataagaga cagcactccc tatcagtgat agagaaaag        59


<210>  143
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  143
gtctcgtggg ctcggagatg tgtataagag acagattcag atcctcttct gagatgag         58


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  144
acctgtttcg cgccacttcc                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  145
gtagaccaga cggctgttgg                                                   20


<210>  146
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  146
agctgaaaua gctgcgcttt tttgtgtcat aactaataac gtaacgtgac tggc             54


<210>  147
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  147
aatcttttcu ccctgataat ttaacacact ttcaaaagag tgtcaacgtg tattgacgca       60

gtcgaacgaa aatcgccatt cgc                                               83


<210>  148
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  148
aaacatgagt aaaggcgaag agctg                                             25


<210>  149
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  149
atttcagcug cgcttttttt atttgtacag ttcatccata ccatgcg                     47


<210>  150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  150
gtgtagaagg gaacggttgg                                                   20


<210>  151
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  151
ttgtattcca gcttatggcc c                                                 21


<210>  152
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  152
cgtgcggaag tgaaatttga agg                                               23


<210>  153
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  153
tttaccttcg tcaccccatt                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  154
tccatcgaca ggggaaacgg                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  155
cgggttttcc gtgctgtata                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  156
cggcgactgg gccgctttcc                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  157
gacacgcgcc ggattattgc                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  158
tcataaatcg actggttaac                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  159
aaacactgag cagagcgcgg                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  160
ggcctaactg cccgttaccg                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  161
attcggaatg ccgacagtgc                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  162
ggcatctttg tagctaagag                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  163
ctgtaaatta cttccgttgc                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  164
gagaaccgaa gtccagaatg                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  165
cggtagagtg agcaggaacg                                                   20


<210>  166
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  166
atgatatgtt tctgatatag                                                   20


<210>  167
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  167
aaaagggctt tacgaacgaa                                                   20


<210>  168
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  168
taagcgcaaa ttcaataaac                                                   20


<210>  169
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  169
aggagaattc gtaacagcgc                                                   20


<210>  170
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  170
ggcaatgcct ttacccagag                                                   20


<210>  171
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  171
tttatagacg ggttttgcat                                                   20


<210>  172
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  172
ggccatcaat ggtaataacc                                                   20


<210>  173
<211>  20
<212>  DNA
<213>  Escherichia coli

<400>  173
acgttttttg ctaccgcgtt                                                   20


<210>  174
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purA (E. coli)

<400>  174
tttaccttcg tcaccccatt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  175
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purB (E. coli)

<400>  175
tccatcgaca ggggaaacgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  176
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purC (E. coli)

<400>  176
cgggttttcc gtgctgtata gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  177
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purD (E. coli)

<400>  177
cggcgactgg gccgctttcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  178
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purE (E. coli)

<400>  178
gacacgcgcc ggattattgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  179
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purF  (E. coli)

<400>  179
tcataaatcg actggttaac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  180
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purH (E. coli)

<400>  180
aaacactgag cagagcgcgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  181
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purK (E. coli)

<400>  181
ggcctaactg cccgttaccg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  182
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purL (E. coli)

<400>  182
attcggaatg ccgacagtgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  183
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purM (E. coli)

<400>  183
ggcatctttg tagctaagag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  184
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting purN (E. coli)

<400>  184
ctgtaaatta cttccgttgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  185
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting guaA (E. coli)

<400>  185
gagaaccgaa gtccagaatg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  186
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting guaB (E. coli)

<400>  186
cggtagagtg agcaggaacg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  187
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrB (E. coli)

<400>  187
atgatatgtt tctgatatag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  188
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrD (E. coli)

<400>  188
aaaagggctt tacgaacgaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  189
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrE (E. coli)

<400>  189
taagcgcaaa ttcaataaac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  190
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrF (E. coli)

<400>  190
aggagaattc gtaacagcgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  191
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrG (E. coli)

<400>  191
ggcaatgcct ttacccagag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  192
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting pyrH (E. coli)

<400>  192
tttatagacg ggttttgcat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  193
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting cmk (E. coli)

<400>  193
ggccatcaat ggtaataacc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  194
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full sequence of sgRNA targeting ndk (E. coli)

<400>  194
acgttttttg ctaccgcgtt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210>  195
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  195
tttaccttcg tcaccccatt gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  196
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  196
aatggggtga cgaaggtaaa actagtcttt tctctatcac tgataggga                   49


<210>  197
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  197
tccatcgaca ggggaaacgg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  198
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  198
ccgtttcccc tgtcgatgga actagtcttt tctctatcac tgataggga                   49


<210>  199
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  199
cgggttttcc gtgctgtata gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  200
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  200
tatacagcac ggaaaacccg actagtcttt tctctatcac tgataggga                   49


<210>  201
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  201
cggcgactgg gccgctttcc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  202
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  202
ggaaagcggc ccagtcgccg actagtcttt tctctatcac tgataggga                   49


<210>  203
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  203
gacacgcgcc ggattattgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  204
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  204
gcaataatcc ggcgcgtgtc actagtcttt tctctatcac tgataggga                   49


<210>  205
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  205
tcataaatcg actggttaac gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  206
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  206
gttaaccagt cgatttatga actagtcttt tctctatcac tgataggga                   49


<210>  207
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  207
aaacactgag cagagcgcgg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  208
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  208
ccgcgctctg ctcagtgttt actagtcttt tctctatcac tgataggga                   49


<210>  209
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  209
ggcctaactg cccgttaccg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  210
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  210
cggtaacggg cagttaggcc actagtcttt tctctatcac tgataggga                   49


<210>  211
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  211
attcggaatg ccgacagtgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  212
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  212
gcactgtcgg cattccgaat actagtcttt tctctatcac tgataggga                   49


<210>  213
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  213
ggcatctttg tagctaagag gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  214
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  214
ctcttagcta caaagatgcc actagtcttt tctctatcac tgataggga                   49


<210>  215
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  215
ctgtaaatta cttccgttgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  216
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  216
gcaacggaag taatttacag actagtcttt tctctatcac tgataggga                   49


<210>  217
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  217
gagaaccgaa gtccagaatg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  218
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  218
cattctggac ttcggttctc actagtcttt tctctatcac tgataggga                   49


<210>  219
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  219
cggtagagtg agcaggaacg gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  220
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  220
cgttcctgct cactctaccg actagtcttt tctctatcac tgataggga                   49


<210>  221
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  221
atgatatgtt tctgatatag gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  222
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  222
ctatatcaga aacatatcat actagtcttt tctctatcac tgataggga                   49


<210>  223
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  223
aaaagggctt tacgaacgaa gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  224
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  224
ttcgttcgta aagccctttt actagtcttt tctctatcac tgataggga                   49


<210>  225
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  225
taagcgcaaa ttcaataaac gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  226
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  226
gtttattgaa tttgcgctta actagtcttt tctctatcac tgataggga                   49


<210>  227
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  227
aggagaattc gtaacagcgc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  228
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  228
gcgctgttac gaattctcct actagtcttt tctctatcac tgataggga                   49


<210>  229
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  229
ggcaatgcct ttacccagag gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  230
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  230
ctctgggtaa aggcattgcc actagtcttt tctctatcac tgataggga                   49


<210>  231
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  231
tttatagacg ggttttgcat gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  232
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  232
atgcaaaacc cgtctataaa actagtcttt tctctatcac tgataggga                   49


<210>  233
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  233
ggccatcaat ggtaataacc gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  234
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  234
ggttattacc attgatggcc actagtcttt tctctatcac tgataggga                   49


<210>  235
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  235
acgttttttg ctaccgcgtt gttttagagc tagaaatagc aagttaaaat aaggc            55


<210>  236
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  236
aacgcggtag caaaaaacgt actagtcttt tctctatcac tgataggga                   49


<210>  237
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  237
accgcctutg agtgagctga tacc                                              24


<210>  238
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  238
aaggcgguaa acgaccgggt catcgt                                            26


<210>  239
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  239
aaccgtucaa gatctttaag acccac                                            26


<210>  240
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  240
aacggtucag ggcagggtcg ttaaatag                                          28


