                         SEQUENCE LISTING

<110>  POLICHEM S.A.
 
<120>  ANTI-HSV SYNERGISTIC ACTIVITY OF ANTIBODIES AND ANTIVIRAL AGENTS

<130>  N411421WO

<150>  EP16181160.9  
<151>  2016-07-26

<160>  13   

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Homo sapiens
<220> 
<223> VH1

<400> 1
Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
1               5                   10                  15      
Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Phe Ala Met His Trp 
            20                  25                  30          
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Ala Phe Ile Ser 
        35                  40                  45              
Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
65                  70                  75                  80  
Ser Leu Arg Ala Glu Asp Thr Ser Ile Tyr Tyr Cys Ala Arg Glu Val 
                85                  90                  95      
Trp Asn Tyr Ala Asp Tyr Trp Gly Gln Gly Ala Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 2
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> VL1

<400> 2
Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Ser Ser Pro Gly His Arg 
1               5                   10                  15      
Ala Thr Leu Ser Cys Lys Ala Ser Ala Pro Leu Gly Ser Asn His Met 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              
Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Arg Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 3
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> VH1 CDR

<400> 3
Glu Val Trp Asn Tyr Ala Asp Tyr 
1               5               

<210> 4
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> VH51

<400> 4
Leu Glu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Arg 
1               5                   10                  15      
Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Ile His 
            20                  25                  30          
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
        35                  40                  45              
Asn Pro Thr Gly Gly Ser Thr Arg Ile Ala Gln Lys Phe Gln Gly Arg 
    50                  55                  60                  
Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ile Phe Met Glu Val 
65                  70                  75                  80  
Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Asp 
                85                  90                  95      
Glu Tyr Lys Ser His His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 5
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> VL3

<400> 5
Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
1               5                   10                  15      
Ala Thr Leu Ser Cys Arg Ala Asn Glu Ser Val Ser Arg Ser Tyr Leu 
            20                  25                  30          
Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              
Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln His Phe Gly Ser Ser Thr Gly Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105         

<210> 6
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> VH51 CDR Fab

<400> 6
Asp Glu Tyr Lys Ser His His Tyr Gly Met Asp Val 
1               5                   10          

<210> 7
<211> 120
<212> PRT
<213> Homo sapiens

<220> 
<223> VH5 Fab C

<400> 7
Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      
Ser Cys Ala Ala Ser Gly Leu Pro Phe Asn Tyr Tyr Ala Met Asn Trp 
            20                  25                  30          
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
        35                  40                  45              
Ala Asn Gly Leu Asn Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe 
    50                  55                  60                  
Thr Ile Ser Arg Glu Asn Ser Gln Asn Thr Leu Tyr Leu Gln Met Asn 
65                  70                  75                  80  
Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Leu 
                85                  90                  95      
Val Ala Ala Thr His Tyr Tyr Tyr Asn Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 8
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> VL5 Fab C

<400> 8
Glu Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly Glu Arg 
1               5                   10                  15      
Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Ser Ser Ser Asn Leu 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              
Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     

<210> 9
<211> 15
<212> PRT
<213> Homo sapiens


<400> 9
Val Leu Val Ala Ala Thr His Tyr Tyr Tyr Asn Gly Met Asp Val 
1               5                   10                  15  

<210> 10
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<223> VH47

<400> 10
Leu Glu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Arg 
1               5                   10                  15      
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Phe Ile His 
            20                  25                  30          
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
        35                  40                  45              
Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala Pro Lys Phe Gln Gly Arg 
    50                  55                  60                  
Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Gln Leu 
65                  70                  75                  80  
Ser Ser Val Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
                85                  90                  95      
Glu Ile Pro Leu Tyr Tyr Asp Ser Gly Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210> 11
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> VL47 Fab H

<400> 11
Glu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
1               5                   10                  15      
Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              
Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Arg Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 12
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> VH47 CDR

<400> 12
Glu Glu Ile Pro Leu Tyr Tyr Asp Ser Gly Tyr Gly Met Asp Val 
1               5                   10                  15  

<210> 13
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> VL51

<400> 13
Glu Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly Glu Arg 
1               5                   10                  15      
Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Ser Ser Ser Asn Leu 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              
Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     

