               SEQUENCE LISTING

<110> THERAVECTYS

<120> LENTIVIRAL VECTORS FOR EXPRESSION OF HEPATITIS B VIRUS (HBV) ANTIGENS

<130> PR78531

<150> EP16305976
<151> 2017-07-27

<160> 26

<170> BiSSAP 1.3.2

<210> 1
<211> 220
<212> DNA
<213> Homo sapiens


<400> 1
attggggagt cccagccttg gggattcccc aactccgcag tttcttttct ccctctccca     60

acctatgtag ggtccttctt cctggatact cacgacgcgg acccagttct cactcccatt    120

gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg gtcgcggttc taaagtccgc    180

acgcacccac cgggactcag attctcccca gacgccgagg                          220


<210> 2
<211> 197
<212> DNA
<213> Homo sapiens


<400> 2
ggggaggcgc agcgttgggg attccccact cccctgagtt tcacttcttc tcccaacttg     60

tgtcgggtcc ttcttccagg atactcgtga cgcgtcccca cttcccactc ccattgggta    120

ttggatatct agagaagcca atcagcgtcg ccgcggtccc agttctaaag tccccacgca    180

cccacccgga ctcagag                                                   197


<210> 3
<211> 216
<212> DNA
<213> Homo sapiens


<400> 3
cactggggag gcgccgcgtt gaggattctc cactcccctc agtttcactt cttctcccaa     60

cctgcgtcgg gtccttcttc ctgaatactc atgacgcgtc cccaattccc actcccattg    120

ggtgtcgggt tctagagaag ccaatcagcg tctccgcagt cccggtctaa agtccccagt    180

cacccacccg gactcagatt ctccccagac gccgag                              216


<210> 4
<211> 205
<212> DNA
<213> Homo sapiens


<400> 4
taagaactgc tgattgctgg gaaactctgc agtttcccgt tcctctcgta acctggtcat     60

gtgtccttct tcctggatac tcatgacgca gactcagttc tcattcccaa tgggtgtcgg    120

gtttctagag aagccaatca gcgtcgccac gactcccgac tataaagtcc ccatccggac    180

tcaagaagtt ctcaggactc agagg                                          205


<210> 5
<211> 252
<212> DNA
<213> Homo sapiens


<400> 5
aggccccgag gcggtgtctg gggttggaag gctcagtatt gagaattccc catctcccca     60

gagtttctct ttctctccca acccgtgtca ggtccttcat cctggatact cataacgcgg    120

ccccatttct cactcccatt gggcgtcgcg tttctagaga agccaatcag tgtcgccgca    180

gttcccaggt tctaaagtcc cacgcacccc gcgggactca tatttttccc agacgcggag    240

gttggggtca tg                                                        252


<210> 6
<211> 192
<212> DNA
<213> Homo sapiens


<400> 6
aacatcacga gactctaaga aaaggaaact gaaaacggga aagtccctct ctctaacctg     60

gcactgcgtc gctggcttgg agacaggtga cggtccctgc gggccttgtc ctgattggct    120

gggcacgcgt ttaatataag tggaggcgtc gcgctggcgg gcattcctga agctgacagc    180

attcgggccg ag                                                        192


<210> 7
<211> 33
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 7
cttactagtt ggaagggcta attcactccc aac                                  33


<210> 8
<211> 32
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 8
cattctagaa ctgctagaga ttttccacac tg                                   32


<210> 9
<211> 42
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 9
taccccgggc catggcctcc aaaaaagcct cctcactact tc                        42


<210> 10
<211> 44
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 10
actcccgggt aatttttttt atttatgcag aggccgaggc cgcc                      44


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 11
tacacgcgtg gagttccgcg ttacataact tacgg                                35


<210> 12
<211> 39
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 12
cgtggatccg atcgcggtgt cttctatgga ggtcaaaac                            39


<210> 13
<211> 34
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 13
gccggcgcgc cgagaaaccc tgcagggaat tccc                                 34


<210> 14
<211> 41
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 14
cgtggatccg atcgctcggc ccgaatgctg tcagcttcag g                         41


<210> 15
<211> 517
<212> DNA
<213> Artificial Sequence

<223> "Amplified B2m promoter sequence"
<223> "Amplified B2m promoter sequence"

<220> 
<223> Amplified B2m promoter sequence

<220> 
<223> Amplified B2m promoter sequence

<400> 15
gagaaaccct gcagggaatt ccccagctgt agttataaac agaagttctc cttctgctag      60

gtagcattca aagatcttaa tcttctgggt ttccgttttc tcgaatgaaa aatgcaggtc     120

cgagcagtta actggcgggg gcaccattag caagtcactt agcatctctg gggccagtct     180

gcaaagcgag ggggcagcct taatgtgcct ccagcctgaa gtcctagaat gagcgcccgg     240

tgtcccaagc tggggcgcgc accccagatc ggagggcgcc gatgtacaga cagcaaactc     300

acccagtcta gtgcatgcct tcttaaacat cacgagactc taagaaaagg aaactgaaaa     360

cgggaaagtc cctctctcta acctggcact gcgtcgctgg cttggagaca ggtgacggtc     420

cctgcgggcc ttgtcctgat tggctgggca cgcgtttaat ataagtggag gcgtcgcgct     480

ggcgggcatt cctgaagctg acagcattcg ggccgag                              517


<210> 16
<211> 47
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 16
atgcatgcgt cgacctcgag ttaatcctca tcctgtctac ttgccac                   47


<210> 17
<211> 65
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 17
gcatgcatcg gccggggcgg cgactggtga gaggccacca tgggtgcgag agcgtcagta     60

ttaag                                                                 65


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 18
cccaagaacc caaggaaca                                                 19


<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<223> "PCR primer"
<223> "PCR primer"

<220> 
<223> PCR primer

<220> 
<223> PCR primer

<400> 19
agacaagata gaggaagagc aaaac                                          25


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "Probe"
<223> "Probe"

<220> 
<223> Probe

<220> 
<223> Probe

<400> 20
aaccattagg agtagcaccc accaagg                                        27


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 21
cggtgaggat cttcatgagg tagt                                           24


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"
<223> "PCR Primer"

<220> 
<223> PCR Primer

<220> 
<223> PCR Primer

<400> 22
aacaccccag ccatgtacgt                                                20


<210> 23
<211> 22
<212> DNA
<213> Artificial Sequence

<223> "Probe"
<223> "Probe"

<220> 
<223> Probe

<220> 
<223> Probe

<400> 23
ccagccaggt ccagacgcag ga                                             22


<210> 24
<211> 1049
<212> PRT
<213> Hepatitis B virus


<400> 24
Met Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly 
1               5                   10                  15      
Leu Gly Ser Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln 
            20                  25                  30          
Asp Pro Arg Val Arg Gly Leu Gly Ser Ser Ile Ser Ala Arg Thr Gly 
        35                  40                  45              
Asp Pro Val Gly Ser Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 
    50                  55                  60                  
Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn 
65                  70                  75                  80  
Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro 
                85                  90                  95      
Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr 
            100                 105                 110         
Arg Trp Met Cys Leu Arg Arg Phe Gly Ser Ile Ile Phe Leu Phe Ile 
        115                 120                 125             
Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 
    130                 135                 140                 
Met Leu Gly Ser Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro 
145                 150                 155                 160 
Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Gly Ser Ile Pro Ser 
                165                 170                 175     
Ser Trp Ala Phe Ala Gly Ser Arg Phe Ser Trp Leu Ser Leu Leu Val 
            180                 185                 190         
Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 
        195                 200                 205             
Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val 
    210                 215                 220                 
Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 
225                 230                 235                 240 
Ile Gly Ser Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 
                245                 250                 255     
Thr Gly Leu Tyr Ser Ser Thr Val Pro Ile Gly Ser Val Gly Pro Leu 
            260                 265                 270         
Thr Val Asn Glu Lys Arg Arg Leu Lys Leu Ile Gly Ser Arg His Tyr 
        275                 280                 285             
Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Gly Ser Thr Pro 
    290                 295                 300                 
Ala Arg Val Thr Gly Gly Val Phe Gly Ser Glu Ser Arg Leu Val Val 
305                 310                 315                 320 
Asp Phe Ser Gln Phe Ser Arg Gly Ile Thr Arg Val Ser Trp Pro Lys 
                325                 330                 335     
Phe Ala Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn 
            340                 345                 350         
Leu Ser Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Ile Pro 
        355                 360                 365             
Leu His Pro Ala Ala Met Pro His Leu Leu Ile Gly Ser Ser Gly Leu 
    370                 375                 380                 
Ser Arg Tyr Val Ala Arg Leu Gly Ser Leu His Leu Tyr Ser His Pro 
385                 390                 395                 400 
Ile Val Leu Gly Phe Arg Lys Ile Gly Ser Ser Ala Ile Cys Ser Val 
                405                 410                 415     
Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp 
            420                 425                 430         
Val Val Leu Gly Ala Gly Ser Phe Leu Leu Ser Leu Gly Ile His Leu 
        435                 440                 445             
Gly Ser Lys His Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp 
    450                 455                 460                 
Trp Gly Ser Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ala 
465                 470                 475                 480 
Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Ser Gly 
                485                 490                 495     
Ser Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr Gly Trp Gly Leu 
            500                 505                 510         
Gly Ser Lys Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Thr Ala Asn 
        515                 520                 525             
Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Gly Ser Ser Leu 
    530                 535                 540                 
Tyr Ala Val Ser Pro Ser Val His Leu Ser Leu Arg Gly Leu Pro Val 
545                 550                 555                 560 
Gly Ser Val Leu His Lys Arg Thr Leu Gly Leu Pro Ala Met Ser Thr 
                565                 570                 575     
Thr Asp Leu Gly Ser Cys Val Phe Lys Asp Trp Glu Glu Leu Gly Glu 
            580                 585                 590         
Glu Ile Arg Leu Lys Val Leu Phe Val Leu Gly Gly Cys Arg His Lys 
        595                 600                 605             
Leu Gly Ser Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe Gly 
    610                 615                 620                 
Pro Gly Phe Gly Ser Met Gln Trp Asn Ser Thr Thr Phe His Gln Ala 
625                 630                 635                 640 
Leu Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser 
                645                 650                 655     
Ser Ser Gly Gly Ser Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr 
            660                 665                 670         
Cys Pro Gly Gln Gly Ser Cys Thr Ile Pro Ala Gln Gly Thr Ser Met 
        675                 680                 685             
Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys 
    690                 695                 700                 
Gly Ser Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met 
705                 710                 715                 720 
Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser Pro Phe Leu Pro 
                725                 730                 735     
Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile Gly Ser Asn Val 
            740                 745                 750         
Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
        755                 760                 765             
Ser Thr Val Pro Val Gly Ser Leu His Leu Tyr Ser His Pro Ile Ile 
    770                 775                 780                 
Leu Gly Phe Arg Lys Ile Gly Ser Lys Gln Cys Phe Arg Lys Leu Pro 
785                 790                 795                 800 
Val Asn Arg Pro Ile Asp Trp Gly Ser Lys Gln Ala Phe Thr Phe Ser 
                805                 810                 815     
Pro Thr Tyr Lys Ala Phe Leu Cys Gly Ser Leu Cys Gln Val Phe Ala 
            820                 825                 830         
Asp Ala Thr Pro Thr Gly Trp Gly Leu Gly Ser Ala Ala Asn Trp Ile 
        835                 840                 845             
Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Gly Ser Val Leu His Lys 
    850                 855                 860                 
Arg Thr Leu Gly Leu Ser Ala Met Ser Thr Thr Asp Leu Gly Ser Cys 
865                 870                 875                 880 
Leu Phe Lys Asp Trp Glu Glu Leu Gly Glu Glu Ile Arg Leu Met Ile 
                885                 890                 895     
Phe Val Leu Gly Gly Cys Arg His Lys Leu Gly Ser Met Asp Ile Asp 
            900                 905                 910         
Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro 
        915                 920                 925             
Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Gly Ser Ala Leu Glu Ser 
    930                 935                 940                 
Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu 
945                 950                 955                 960 
Gly Ser Glu Leu Met Thr Leu Ala Thr Trp Val Gly Ser Ser Arg Asp 
                965                 970                 975     
Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln 
            980                 985                 990         
Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 
        995                 1000                1005            
Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Gly 
    1010                1015                1020                
Ser Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg Asp 
1025                1030                1035                1040
Arg Gly Arg Ser Pro Arg Arg Arg Thr 
                1045                

<210> 25
<211> 468
<212> PRT
<213> Hepatitis B virus


<400> 25
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      
Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          
Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              
Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  
Leu Met Thr Leu Ala Thr Trp Val Gly Asn Asn Leu Glu Asp Gly Gly 
65                  70                  75                  80  
Gly Gly Ser Gly Gly Gly Gly Thr Pro Leu Gly Phe Phe Pro Asp His 
                85                  90                  95      
Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            100                 105                 110         
Phe Asn Gly Ser Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr 
        115                 120                 125             
Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Met Gln Trp Asn 
    130                 135                 140                 
Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu 
145                 150                 155                 160 
Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro 
                165                 170                 175     
Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Gly 
            180                 185                 190         
Ser Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro 
        195                 200                 205             
Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro 
    210                 215                 220                 
Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser 
225                 230                 235                 240 
Gly Ser Pro Phe Val Gln Trp Phe Val Gly Leu Ala Met Gln Trp Asn 
                245                 250                 255     
Ser Thr Thr Phe His Gln Ala Leu Leu Asp Pro Arg Val Arg Gly Leu 
            260                 265                 270         
Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Val Pro 
        275                 280                 285             
Thr Thr Ala Ser Pro Ile Ser Ser Ile Phe Ser Arg Thr Gly Asp Gly 
    290                 295                 300                 
Ser Cys Lys Thr Cys Thr Ile Pro Ala Gln Gly Thr Ser Met Phe Pro 
305                 310                 315                 320 
Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys Ile Pro 
                325                 330                 335     
Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe Leu Trp Glu Trp Ala Ser 
            340                 345                 350         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Asp Leu Val 
        355                 360                 365             
Val Asn Tyr Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu 
    370                 375                 380                 
Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu 
385                 390                 395                 400 
Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg 
                405                 410                 415     
Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 
            420                 425                 430         
Arg Arg Arg Asp Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro 
        435                 440                 445             
Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 
    450                 455                 460                 
Glu Ser Gln Cys 
465             

<210> 26
<211> 141
<212> PRT
<213> Artificial Sequence

<223> "HBV consensus core MHCI and MHCII epitopes of genotypes A and/or C antigen"
<223> HBV consensus core MHCI and MHCII epitopes of genotypes A and/or C antigen

<220> 
<223> HBV consensus core MHCI and MHCII epitopes of genotypes A and/or
      C antigen

<220> 
<223> HBV consensus core MHCI and MHCII epitopes of genotypes A and/or
      C antigen

<400> 26
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      
Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Gly Ser 
            20                  25                  30          
Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg 
        35                  40                  45              
Gln Ala Ile Leu Gly Ser Glu Leu Met Thr Leu Ala Thr Trp Val Gly 
    50                  55                  60                  
Ser Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu 
65                  70                  75                  80  
Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
                85                  90                  95      
Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
            100                 105                 110         
Thr Pro Pro Gly Ser Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val 
        115                 120                 125             
Arg Arg Arg Asp Arg Gly Arg Ser Pro Arg Arg Arg Thr 
    130                 135                 140     

