                               SEQUENCE LISTING

<110> MASSACHUSETTS INSTITUTE OF TECHNOLOGY
 
<120> SELECTIVE BFL-1 PEPTIDES

<130> 39076-0006WO1

<140> PCT/US2017/043219
<141> 2017-07-21

<150> 62/517,146
<151> 2017-06-08

<150> 62/365,484
<151> 2016-07-22

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Q or a conservative substitution, or not present 

<220>
<221> MOD_RES
<222> (2)..(2)
<223> W or a conservative substitution, G or a conservative 
      substitution, 4, 4-biphenylalanine, azidoalanine, 
      or not present 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> A or a conservative substitution, V or a conservative  
      substitution, or I or a conservative substitution 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> R or a conservative substitution 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> E or a conservative substitution, H or a conservative  
      substitution, or 2,3-diaminopropanoic acid 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> I or a conservative substitution, norleucine, homoleucine, 
      cyclohexylalanine, 2-aminoheptanoic acid, or  
      2,4-diaminobutyric acid 

<220>
<221> MOD_RES
<222> (7)..(7)
<223> G or a conservative substitution, or A or a conservative 
      substitution 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> A or a conservative substitution, or Y or a conservative  
      substitution 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Q or a conservative substitution, G or a conservative  
      substitution, D or a conservative substitution, or E or a  
      conservative substitution 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> L or a conservative substitution, cyclohexylalanine, or  
      homoleucine 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> R or a conservative substitution 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> R or a conservative substitution, or L or a conservative  
      substitution 

<220>
<221> MOD_RES
<222> (13)..(13)
<223> M or a conservative substitution, A or a conservative  
      substitution, F or a conservative substitution, 
      d-phenylglycine, d-histidine, d-leucine, alpha-aminoisobutyric 
      acid, or cyclohexanecarboxylic acid 

<220>
<221> MOD_RES
<222> (14)..(14)
<223> A or a conservative substitution, ornithine, 2,4-diaminobutyric  
      acid, or 2,3-diaminopropanoic acid 

<220>
<221> MOD_RES
<222> (15)..(15)
<223> D or a conservative substitution, or homoglutamate 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> D or a conservative substitution, N or a conservative  
      substitution, or I or a conservative substitution 

<220>
<221> MOD_RES
<222> (17)..(17)
<223> L or a conservative substitution, V or a conservative  
      substitution, or d-cyclohexylalanine 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> N or a conservative substitution 

<220>
<221> MOD_RES
<222> (19)..(19)
<223> A or a conservative substitution 

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Q or a conservative substitution 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Y or a conservative substitution, L or a conservative  
      substitution, or V or a conservative substitution 

<220>
<221> MOD_RES
<222> (22)..(22)
<223> E or a conservative substitution 

<220>
<221> MOD_RES
<222> (23)..(23)
<223> R or a conservative substitution 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 1
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20              


<210> 2
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gln Trp Val Arg Glu Ile Ala Ala Gly Leu Arg Leu Ala Ala Asp Asn 
1               5                   10                  15      


Val Asn Ala Gln Leu Glu Arg 
            20              


<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gln Trp Val Arg Glu Ile Ala Ala Gly Leu Arg Arg Ala Ala Asp Asp 
1               5                   10                  15      


Val Asn Ala Gln Val Glu Arg 
            20              


<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gln Trp Ile Arg Glu Ile Ala Ala Gly Leu Arg Arg Phe Ala Asp Ile 
1               5                   10                  15      


Leu Asn Ala Gln Val Glu Arg 
            20              


<210> 5
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Val Arg Glu Ile Ala Tyr Gly Leu Arg Arg Ala Ala Asp Asp Val Asn 
1               5                   10                  15      


Ala Gln Val Glu Arg 
            20      


<210> 6
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met Ala Asp Asp 
1               5                   10                  15      


Leu Asn Ala Gln Val Glu Arg 
            20              


<210> 7
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gln Trp Val Arg Glu Ile Ala Ala Gly Leu Arg Arg Ala Ala Asp Asp 
1               5                   10                  15      


Val Asn Ala Gln Tyr Glu Arg 
            20              


<210> 8
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gln Trp Val Arg Glu Ile Ala Ala Gln Leu Arg Arg Met Ala Asp Asp 
1               5                   10                  15      


Leu Asn Ala Gln Tyr Glu Arg 
            20              


<210> 9
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gln Trp Ala Arg Glu Ile Gly Ala Gly Leu Arg Arg Ala Ala Asp Asp 
1               5                   10                  15      


Val Asn Ala Gln Val Glu Arg 
            20              


<210> 10
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Val Arg Glu Ile Ala Tyr Gly Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 11
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Val Arg His Ile Ala Tyr Gly Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 12
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Val Arg His Ile Ala Tyr Asp Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 13
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Val Arg His Ile Ala Tyr Glu Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 14
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2,3-diaminopropanoic acid 

<400> 14
Gly Val Arg Xaa Ile Ala Tyr Gly Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 15
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> 2,4-diaminobutyric acid 

<400> 15
Gly Val Arg Glu Xaa Ala Tyr Gly Leu Arg Arg Ala Ala Asp Asp Val 
1               5                   10                  15      


Asn Ala Gln Val Glu Arg 
            20          


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 17
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(11)
<223> This sequence may encompass 7 to 11 residues 

<400> 20
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210> 21
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 22
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Cys Tyr Gly Gly Arg Gly Asp Thr Pro 
1               5                   


<210> 26
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
1               5                   10                  15      


Tyr Tyr 
        


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 28
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (38)..(38)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (50)..(50)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (62)..(62)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (74)..(74)
<223> a, c, t, g, unknown or other

<400> 28
cggatccggt ggccaatggv hacgtgaaat tkvtgccndc ctgcgtcgcn bcgcggatvw       60

knhtaatgcc caanytgaac gtcgtcgcca ggaggaac                               98


<210> 29
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cgccttgttc ctcctggcga cgacgttcat attgggc                                37


<210> 30
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> A, E, I, K, L, P, Q, T or V

<220>
<221> MOD_RES
<222> (6)..(6)
<223> G, A, C, D, S or Y

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Q, C, D, F, G, H, I, L, N, R, S, V or Y

<220>
<221> MOD_RES
<222> (12)..(12)
<223> M, A, C, F, G, I, L, P, R, S, T or V

<220>
<221> MOD_RES
<222> (15)..(15)
<223> D, E, H, I, K, L, M, N, Q or V

<220>
<221> MOD_RES
<222> (16)..(16)
<223> L, A, D, F, H, I, N, P, S, T, V or Y

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Y, A, F, I, L, P, S, T or V

<400> 30
Trp Xaa Arg Glu Ile Xaa Ala Xaa Leu Arg Arg Xaa Ala Asp Xaa Xaa 
1               5                   10                  15      


Asn Ala Gln Xaa Glu Arg 
            20          


<210> 31
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met Ala Asp Asp 
1               5                   10                  15      


Leu Asn Ala Gln Tyr Glu Arg 
            20              


<210> 32
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met Ala Asp Asp 
1               5                   10                  15      


Leu Asn Ala Gln Tyr Glu 
            20          


<210> 33
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Gln Trp Val Arg Glu Ile Ala Ala Gly Leu Arg Arg Ala Ala Asp Asp 
1               5                   10                  15      


Val Asn Ala Gln Val Glu 
            20          


<210> 34
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Val Arg Glu Ile Ala Ala Gly Leu Arg Arg Ala Ala Asp Asp Val Asn 
1               5                   10                  15      


Ala Gln Val Glu Arg 
            20      


