                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> METHODS FOR INDUCING STEREOCILIA ON HAIR CELLS

<130> UCSDP046WO

<140> PCT/US2017/043075
<141> 2017-07-20

<150> 62/365,189
<151> 2016-07-21

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 3531
<212> DNA
<213> Homo sapiens

<400> 1
agcggagcgc caggcagcgc ggagcggagg ccaggcccac agccgctccg cctcccggcc       60

cgcagatccc cgacggccgc accgcgggct cctctggccc gcaagaacac gtgcatggcg      120

tcctggggaa ggcgctgagt gcggagtcgc ggcgccgcac gcggcaccat ggccctggag      180

caggcgctgc aggcggcgcg gcagggcgag ctggacgtgc tgaggtcgct gcacgccgca      240

ggcctcctgg ggccctcgct gcgcgacccg ctggacgcgc tgcccgtgca ccacgcggcc      300

cgcgctggga agctgcactg tctgcgcttc ctggtggagg aagccgccct ccccgccgcg      360

gcccgcgccc gcaacggcgc cacaccggcc cacgacgcct ccgccaccgg ccacctcgcc      420

tgcctgcagt ggctgctgtc gcagggcggc tgcagagtgc aggacaaaga caattctggt      480

gccacagtct tgcatctggc tgcccgcttc ggccaccccg aggtggtgaa ctggctcttg      540

catcatggcg gtggggaccc caccgcggcc acagacatgg gcgccctgcc tatccactac      600

gctgccgcca aaggagactt cccctccctg aggcttctcg tcgagcacta ccctgaggga      660

gtgaatgccc aaaccaagaa cggtgccacg cccctgtacc tggcgtgcca ggagggccac      720

ctggaggtga cccagtacct ggtgcaggaa tgcggcgcag acccgcacgc gcgcgcccac      780

gacggcatga ccccgctgca cgccgcggcg cagatgggcc acagcccagt catcgtgtgg      840

ttggtgagct gcaccgacgt gagcctgtcc gagcaggaca aagacggcgc caccgccatg      900

cacttcgcgg cgagccgcgg ccacaccaag gtgctcagct ggctgctgct gcacggcggg      960

gagatctcgg ctgacctgtg gggcgggacc ccgctgcacg acgccgccga gaacggggag     1020

ctagagtgct gccagatcct ggtagtgaac ggcgcggagc tggacgtccg cgaccgcgac     1080

gggtacacgg ccgccgacct gtcggacttc aacggccaca gccactgcac ccgctacctg     1140

cgcacggtgg agaacctgag cgtggagcac cgcgtgcttt cccgggatcc atccgcagag     1200

ctggaggcta agcagccgga ttcaggcatg tcctcaccca ataccacggt gtcggtccag     1260

ccgctgaact ttgacctcag ctcgcctacc agcaccctct ccaactacga ctcctgctcc     1320

tccagccact ccagcatcaa gggccagcac cctccatgtg ggctttccag cgctagagct     1380

gcagacatac agagctacat ggacatgctg aacccggagc tgggcctgcc tcggggcacg     1440

attgggaagc ccacaccccc accaccccca cccagcttcc ccccgccacc cccgccccca     1500

ggcacccaac tgcccccacc cccacctggc tacccagctc ccaagcctcc tgtaggacca     1560

caggcagctg acatctacat gcagaccaag aacaaactcc gccacgtgga gacagaggcc     1620

ctcaagaagg agctgagctc ctgtgacggc cacgacgggc tgcggaggca ggactccagc     1680

cgcaagcccc gcgccttcag caagcagccc agcacggggg actactaccg gcagctgggc     1740

cgctgccccg gcgagacgct ggccgcacgc ccgggcatgg cgcacagcga ggaggtgcgt     1800

gcccgccagc ccgcgcgcgc cggctgcccg cgcctcggcc ctgccgcccg cggctcactc     1860

gaaggcccct ccgctccccc gcaggcggcg ctgcttcctg ggaaccatgt tcctaacggc     1920

tgcgccgcgg accccaaggc gtccagggag ctgccaccgc cgcccccacc gccgccgccg     1980

cccctgccgg aggccgcgag ttcgccaccg ccggccccgc ctctgcccct cgagagcgct     2040

ggccctggct gcgggcagcg ccgctcctcc tcgtccaccg gcagcaccaa gtctttcaac     2100

atgatgtccc cgacgggcga caactcggag ctactggctg agattaaggc aggcaagagc     2160

ctgaagccga cgccccagag caaggggctg accacagtgt tctcaggcat cgggcagccg     2220

gccttccagc ccgattcgcc gctgccttct gtgtcacctg cactgtcacc agtccggagc     2280

cccacaccgc cagctgcggg gtttcagccg ctgctcaatg gaagcttggt tcccgtgccg     2340

cccactactc ctgcgccggg agtgcagctg gacgtggagg ctctcatccc cacgcacgat     2400

gagcagggcc ggcccatccc cgagtggaag cgccaggtga tggtgcgcaa gatgcagctg     2460

aagatgcagg aggaggagga gcagaggcgg aaggaggagg aggaggaggc ccggctggcc     2520

agcatgcccg cctggaggcg ggacctcctg cggaagaagc tggaagaaga gagggagcag     2580

aagcggaaag aggaggagcg acagaagcag gaggagctgc ggcgggagaa ggaacagtca     2640

gagaagctgc ggacgctggg ctacgatgag agcaagctgg cgccctggca gcgacaggtc     2700

atcctgaaga agggggacat cgctaagtac tagaggccgc agactcctgt ccgcagcctc     2760

gcagctccgt ggggccctcc gccccagccc cagccagcca ggccctggtg gaaaggctgg     2820

gagccgcaca gccctcccct cctgcgctgg aaaccctccc tgacccccac cctggccccc     2880

cgtatcccca gcccttggca acactggagt gcacacgccg ccacggttgc ccagaaaaag     2940

tgcccaagct gctgacgcaa acaacaacaa atgctgctta tttgcatgcc gacttacata     3000

tatttgcatg ttcgttgact atcaaagagt gcagagctct ccccagcccc gtgggtggtg     3060

actttgtttt cctgcggggc tcagccccct ccaggatgca gccccctccc ccgcaccccg     3120

gaaccggcgt cgctggcgca tcctgggtgg aggcaggccc cgagctcggg gaaggggttt     3180

tcccttcctc tctgacccag atctgcgcgc ggcctagccc gggcctcatt tcttatcccc     3240

gccaagggtt tcctctcagt catttgttta ccagaaacat gaaaactgcc tgtctggccg     3300

ggccgcactt gtggcccccg ggaccccacc tctggcccca cctccctcaa gtctgcgccc     3360

cgtccccagc cagacccact cgctgccggg accctttcac tgccccggtg gagtgaatag     3420

aggatgaggg gccctgaccc tgtgtctcca actgctgcac cccatcccga ccctgtctcc     3480

gccacctcgc agccccatta aagcgctctc atctgggctc cggttcactc a              3531


<210> 2
<211> 854
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp 
1               5                   10                  15      


Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg 
            20                  25                  30          


Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys 
        35                  40                  45              


Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala 
    50                  55                  60                  


Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr 
65                  70                  75                  80  


Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg 
                85                  90                  95      


Val Gln Asp Lys Asp Asn Ser Gly Ala Thr Val Leu His Leu Ala Ala 
            100                 105                 110         


Arg Phe Gly His Pro Glu Val Val Asn Trp Leu Leu His His Gly Gly 
        115                 120                 125             


Gly Asp Pro Thr Ala Ala Thr Asp Met Gly Ala Leu Pro Ile His Tyr 
    130                 135                 140                 


Ala Ala Ala Lys Gly Asp Phe Pro Ser Leu Arg Leu Leu Val Glu His 
145                 150                 155                 160 


Tyr Pro Glu Gly Val Asn Ala Gln Thr Lys Asn Gly Ala Thr Pro Leu 
                165                 170                 175     


Tyr Leu Ala Cys Gln Glu Gly His Leu Glu Val Thr Gln Tyr Leu Val 
            180                 185                 190         


Gln Glu Cys Gly Ala Asp Pro His Ala Arg Ala His Asp Gly Met Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Gln Met Gly His Ser Pro Val Ile Val Trp 
    210                 215                 220                 


Leu Val Ser Cys Thr Asp Val Ser Leu Ser Glu Gln Asp Lys Asp Gly 
225                 230                 235                 240 


Ala Thr Ala Met His Phe Ala Ala Ser Arg Gly His Thr Lys Val Leu 
                245                 250                 255     


Ser Trp Leu Leu Leu His Gly Gly Glu Ile Ser Ala Asp Leu Trp Gly 
            260                 265                 270         


Gly Thr Pro Leu His Asp Ala Ala Glu Asn Gly Glu Leu Glu Cys Cys 
        275                 280                 285             


Gln Ile Leu Val Val Asn Gly Ala Glu Leu Asp Val Arg Asp Arg Asp 
    290                 295                 300                 


Gly Tyr Thr Ala Ala Asp Leu Ser Asp Phe Asn Gly His Ser His Cys 
305                 310                 315                 320 


Thr Arg Tyr Leu Arg Thr Val Glu Asn Leu Ser Val Glu His Arg Val 
                325                 330                 335     


Leu Ser Arg Asp Pro Ser Ala Glu Leu Glu Ala Lys Gln Pro Asp Ser 
            340                 345                 350         


Gly Met Ser Ser Pro Asn Thr Thr Val Ser Val Gln Pro Leu Asn Phe 
        355                 360                 365             


Asp Leu Ser Ser Pro Thr Ser Thr Leu Ser Asn Tyr Asp Ser Cys Ser 
    370                 375                 380                 


Ser Ser His Ser Ser Ile Lys Gly Gln His Pro Pro Cys Gly Leu Ser 
385                 390                 395                 400 


Ser Ala Arg Ala Ala Asp Ile Gln Ser Tyr Met Asp Met Leu Asn Pro 
                405                 410                 415     


Glu Leu Gly Leu Pro Arg Gly Thr Ile Gly Lys Pro Thr Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro Pro Gly Thr Gln Leu 
        435                 440                 445             


Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Lys Pro Pro Val Gly Pro 
    450                 455                 460                 


Gln Ala Ala Asp Ile Tyr Met Gln Thr Lys Asn Lys Leu Arg His Val 
465                 470                 475                 480 


Glu Thr Glu Ala Leu Lys Lys Glu Leu Ser Ser Cys Asp Gly His Asp 
                485                 490                 495     


Gly Leu Arg Arg Gln Asp Ser Ser Arg Lys Pro Arg Ala Phe Ser Lys 
            500                 505                 510         


Gln Pro Ser Thr Gly Asp Tyr Tyr Arg Gln Leu Gly Arg Cys Pro Gly 
        515                 520                 525             


Glu Thr Leu Ala Ala Arg Pro Gly Met Ala His Ser Glu Glu Val Arg 
    530                 535                 540                 


Ala Arg Gln Pro Ala Arg Ala Gly Cys Pro Arg Leu Gly Pro Ala Ala 
545                 550                 555                 560 


Arg Gly Ser Leu Glu Gly Pro Ser Ala Pro Pro Gln Ala Ala Leu Leu 
                565                 570                 575     


Pro Gly Asn His Val Pro Asn Gly Cys Ala Ala Asp Pro Lys Ala Ser 
            580                 585                 590         


Arg Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu 
        595                 600                 605             


Ala Ala Ser Ser Pro Pro Pro Ala Pro Pro Leu Pro Leu Glu Ser Ala 
    610                 615                 620                 


Gly Pro Gly Cys Gly Gln Arg Arg Ser Ser Ser Ser Thr Gly Ser Thr 
625                 630                 635                 640 


Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser Glu Leu Leu 
                645                 650                 655     


Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro Gln Ser Lys 
            660                 665                 670         


Gly Leu Thr Thr Val Phe Ser Gly Ile Gly Gln Pro Ala Phe Gln Pro 
        675                 680                 685             


Asp Ser Pro Leu Pro Ser Val Ser Pro Ala Leu Ser Pro Val Arg Ser 
    690                 695                 700                 


Pro Thr Pro Pro Ala Ala Gly Phe Gln Pro Leu Leu Asn Gly Ser Leu 
705                 710                 715                 720 


Val Pro Val Pro Pro Thr Thr Pro Ala Pro Gly Val Gln Leu Asp Val 
                725                 730                 735     


Glu Ala Leu Ile Pro Thr His Asp Glu Gln Gly Arg Pro Ile Pro Glu 
            740                 745                 750         


Trp Lys Arg Gln Val Met Val Arg Lys Met Gln Leu Lys Met Gln Glu 
        755                 760                 765             


Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala Arg Leu Ala 
    770                 775                 780                 


Ser Met Pro Ala Trp Arg Arg Asp Leu Leu Arg Lys Lys Leu Glu Glu 
785                 790                 795                 800 


Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys Gln Glu Glu 
                805                 810                 815     


Leu Arg Arg Glu Lys Glu Gln Ser Glu Lys Leu Arg Thr Leu Gly Tyr 
            820                 825                 830         


Asp Glu Ser Lys Leu Ala Pro Trp Gln Arg Gln Val Ile Leu Lys Lys 
        835                 840                 845             


Gly Asp Ile Ala Lys Tyr 
    850                 


<210> 3
<211> 2861
<212> DNA
<213> Mus musculus

<400> 3
atggccctgg agcaggcgct gcaggcggca cggcggggcg acctggacgt gctgaggtcc       60

ctgcacgccg ccggcctgct ggggccttct ctgcgcgact cgctagacgc cctgccggtg      120

caccatgcgg cccgctcagg caagctgcac tgtctgcgct acttggtgga ggaggttgcc      180

ctcccagccg tgtcccgcgc gcgcaacggc gccacaccag cccatgacgc cgccgccaca      240

ggctacctct cttgcctgca gtggctgctc acacagggtg gctgcagggt gcaggaaaaa      300

gataactctg gtgccacagt cctgcatctg gctgcccgct ttggccaccc ggatgtggtg      360

aagtggctgc tgtaccaggg cggtgcaaat tcggccatca ccacagacac gggcgccctg      420

cctatccact acgctgccgc caaaggagac ctcccctcgc tgaagcttct ggtcgggcat      480

taccctgagg gagtgaatgc ccaaaccaac aacggtgcca cgcccctgta cctggcgtgc      540

caggagggcc acctggaagt gacgaagtac cttgtgcagg agtgcagtgc agatccgcac      600

ctgcgcgccc aagacggcat gacaccccta catgccgcag cacagatggg ccacaaccca      660

gtcttggtgt ggctggtgag ctttgcagac gttagctttt cagagcagga ccacgacggc      720

gccacggcca tgcactttgc tgccagtcgc ggccacacca aagtgctcag ctggctcctg      780

ctgcacgggg cagagatctc gcaggacctg tggggcggaa ccccgctgca tgacgctgct      840

gagaacgggg aactggagtg ctgccagatc ctcgcggtga acggcgctgg gctggacgtc      900

cgcgaccacg atgggtacac cgctgccgac ctggcagagt tcaatggcca cacccactgt      960

tcccgctacc tacgtacggt gcaaaccctg agcttggaac accgagtctt gtcccgggat     1020

caatccatgg acctggaggc aaagcagctg gactcgggta tgtcctcgcc caacaccacc     1080

atgtcggtcc agccaatgac ctttgacctg ggctcgccta ctagcacgtt ctccaactat     1140

gactcctgct cctccagtca ctccagcagc aaggggcagc gatcgaatcg agggattcca     1200

ggtgcaagag ctgcagactt acagagctac atggacatgc tgaacccaga gaagagcttg     1260

cctcggggca agctagggaa gccttccccg ccaccacctc caccaccacc accaccaagc     1320

ttcccgccac ccccaccacc cacaggcacc cagccgcccc cacctccacc aggctaccca     1380

gctcccaatc cccctgtggg actgcatctg aataacattt acatgcagac caagaacaag     1440

cttcgccatg tggaggtgga ctcgctcaag gagcccaagg tggagctgaa cgatcagttt     1500

gcacagccga gctcgggcga cggccactcg gggctacaca ggcaggactc cgggctgctc     1560

aggcaggatt cggagctgct gcacaggcag gagctgctca ggcacagcac cggactgcgc     1620

aggcaggact ccgaccgcaa acagcgctcg ttcagtaaac agcccagcac gggggactac     1680

taccgccagc tgggccgcag cccgggggag ccgctggccg cacgcccggg catggcccac     1740

agcgaggagg cggcgctgct ccccgggaac cacgtgcaca acggctgctc agcggactcc     1800

aaagcgtcca gggagctgcc gccgccaccg ccgccgccgc cgctgcccga ggccctgagt     1860

tcgccgccgc ccgccccacc tctgcccatc gagggcgcgg gcgcagcctg cgggcagcgt     1920

cgttcctcgt cttctactgg caaagtgaga gtcctgagac acaggaagag caccaaatct     1980

ttcaacatga tgtccccaac gggtgataac tcagagcttc tggctgagat aaaggcgggc     2040

aagagcctga agccgacacc gcagagcaag gggctgacaa ccgtgttctc aggcagtggg     2100

cagccagcct cccagcctga gtcaccgcag cctctggtgt cacctgcgcc atctcggact     2160

cggagcccca ccccgccagc ctctgggtct cagccactgc tcaatggcag tgtggtgccg     2220

gcaccacctg ccaccccggc acctggagtc catctggatg tggaggccct cattcccact     2280

cttgatgagc agggccggcc catcccggag tggaagcgcc aggtgatggt ccgcaagctg     2340

cagcagaaga tgcaggagga agaggagcag cggaggaagg aggaagagga ggaggcccgg     2400

ctcgccagcc tgcctgcctg gagacgagac attcttcgga agaagctgga ggaggagagg     2460

gagcagaagc gaaaagagga ggagcggcaa aagctggagg aaatacagag ggcgaaagaa     2520

cagtcggaga agctgcggac actaggctac gacgaagcca agctcgcgcc ctggcagcga     2580

caggtcatct tgaagaaggg ggagatccct aagtaatagg agtctctcgg cttcttgcgt     2640

gtagcctcac aagttctgag agatggggag cggcccccag cccccgcccc atcctgtcag     2700

gttggtgcgg aagggctagg atccttgccg cccttccctt cggtgccgga accctcccaa     2760

ttcccctccc tggccccaca tccccaaccc tgctgctgga gtgctctcgc aaacccctgc     2820

tgtcgcctgg aaaaaagtgc ccaagctgct gacgcaaaaa g                         2861


<210> 4
<211> 871
<212> PRT
<213> Mus musculus

<400> 4
Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Arg Gly Asp Leu Asp 
1               5                   10                  15      


Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg 
            20                  25                  30          


Asp Ser Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ser Gly Lys 
        35                  40                  45              


Leu His Cys Leu Arg Tyr Leu Val Glu Glu Val Ala Leu Pro Ala Val 
    50                  55                  60                  


Ser Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ala Ala Thr 
65                  70                  75                  80  


Gly Tyr Leu Ser Cys Leu Gln Trp Leu Leu Thr Gln Gly Gly Cys Arg 
                85                  90                  95      


Val Gln Glu Lys Asp Asn Ser Gly Ala Thr Val Leu His Leu Ala Ala 
            100                 105                 110         


Arg Phe Gly His Pro Asp Val Val Lys Trp Leu Leu Tyr Gln Gly Gly 
        115                 120                 125             


Ala Asn Ser Ala Ile Thr Thr Asp Thr Gly Ala Leu Pro Ile His Tyr 
    130                 135                 140                 


Ala Ala Ala Lys Gly Asp Leu Pro Ser Leu Lys Leu Leu Val Gly His 
145                 150                 155                 160 


Tyr Pro Glu Gly Val Asn Ala Gln Thr Asn Asn Gly Ala Thr Pro Leu 
                165                 170                 175     


Tyr Leu Ala Cys Gln Glu Gly His Leu Glu Val Thr Lys Tyr Leu Val 
            180                 185                 190         


Gln Glu Cys Ser Ala Asp Pro His Leu Arg Ala Gln Asp Gly Met Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Gln Met Gly His Asn Pro Val Leu Val Trp 
    210                 215                 220                 


Leu Val Ser Phe Ala Asp Val Ser Phe Ser Glu Gln Asp His Asp Gly 
225                 230                 235                 240 


Ala Thr Ala Met His Phe Ala Ala Ser Arg Gly His Thr Lys Val Leu 
                245                 250                 255     


Ser Trp Leu Leu Leu His Gly Ala Glu Ile Ser Gln Asp Leu Trp Gly 
            260                 265                 270         


Gly Thr Pro Leu His Asp Ala Ala Glu Asn Gly Glu Leu Glu Cys Cys 
        275                 280                 285             


Gln Ile Leu Ala Val Asn Gly Ala Gly Leu Asp Val Arg Asp His Asp 
    290                 295                 300                 


Gly Tyr Thr Ala Ala Asp Leu Ala Glu Phe Asn Gly His Thr His Cys 
305                 310                 315                 320 


Ser Arg Tyr Leu Arg Thr Val Gln Thr Leu Ser Leu Glu His Arg Val 
                325                 330                 335     


Leu Ser Arg Asp Gln Ser Met Asp Leu Glu Ala Lys Gln Leu Asp Ser 
            340                 345                 350         


Gly Met Ser Ser Pro Asn Thr Thr Met Ser Val Gln Pro Met Thr Phe 
        355                 360                 365             


Asp Leu Gly Ser Pro Thr Ser Thr Phe Ser Asn Tyr Asp Ser Cys Ser 
    370                 375                 380                 


Ser Ser His Ser Ser Ser Lys Gly Gln Arg Ser Asn Arg Gly Ile Pro 
385                 390                 395                 400 


Gly Ala Arg Ala Ala Asp Leu Gln Ser Tyr Met Asp Met Leu Asn Pro 
                405                 410                 415     


Glu Lys Ser Leu Pro Arg Gly Lys Leu Gly Lys Pro Ser Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro Thr 
        435                 440                 445             


Gly Thr Gln Pro Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Asn Pro 
    450                 455                 460                 


Pro Val Gly Leu His Leu Asn Asn Ile Tyr Met Gln Thr Lys Asn Lys 
465                 470                 475                 480 


Leu Arg His Val Glu Val Asp Ser Leu Lys Glu Pro Lys Val Glu Leu 
                485                 490                 495     


Asn Asp Gln Phe Ala Gln Pro Ser Ser Gly Asp Gly His Ser Gly Leu 
            500                 505                 510         


His Arg Gln Asp Ser Gly Leu Leu Arg Gln Asp Ser Glu Leu Leu His 
        515                 520                 525             


Arg Gln Glu Leu Leu Arg His Ser Thr Gly Leu Arg Arg Gln Asp Ser 
    530                 535                 540                 


Asp Arg Lys Gln Arg Ser Phe Ser Lys Gln Pro Ser Thr Gly Asp Tyr 
545                 550                 555                 560 


Tyr Arg Gln Leu Gly Arg Ser Pro Gly Glu Pro Leu Ala Ala Arg Pro 
                565                 570                 575     


Gly Met Ala His Ser Glu Glu Ala Ala Leu Leu Pro Gly Asn His Val 
            580                 585                 590         


His Asn Gly Cys Ser Ala Asp Ser Lys Ala Ser Arg Glu Leu Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Pro Pro Leu Pro Glu Ala Leu Ser Ser Pro Pro Pro 
    610                 615                 620                 


Ala Pro Pro Leu Pro Ile Glu Gly Ala Gly Ala Ala Cys Gly Gln Arg 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Thr Gly Lys Val Arg Val Leu Arg His Arg Lys 
                645                 650                 655     


Ser Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser Glu 
            660                 665                 670         


Leu Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro Gln 
        675                 680                 685             


Ser Lys Gly Leu Thr Thr Val Phe Ser Gly Ser Gly Gln Pro Ala Ser 
    690                 695                 700                 


Gln Pro Glu Ser Pro Gln Pro Leu Val Ser Pro Ala Pro Ser Arg Thr 
705                 710                 715                 720 


Arg Ser Pro Thr Pro Pro Ala Ser Gly Ser Gln Pro Leu Leu Asn Gly 
                725                 730                 735     


Ser Val Val Pro Ala Pro Pro Ala Thr Pro Ala Pro Gly Val His Leu 
            740                 745                 750         


Asp Val Glu Ala Leu Ile Pro Thr Leu Asp Glu Gln Gly Arg Pro Ile 
        755                 760                 765             


Pro Glu Trp Lys Arg Gln Val Met Val Arg Lys Leu Gln Gln Lys Met 
    770                 775                 780                 


Gln Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala Arg 
785                 790                 795                 800 


Leu Ala Ser Leu Pro Ala Trp Arg Arg Asp Ile Leu Arg Lys Lys Leu 
                805                 810                 815     


Glu Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys Leu 
            820                 825                 830         


Glu Glu Ile Gln Arg Ala Lys Glu Gln Ser Glu Lys Leu Arg Thr Leu 
        835                 840                 845             


Gly Tyr Asp Glu Ala Lys Leu Ala Pro Trp Gln Arg Gln Val Ile Leu 
    850                 855                 860                 


Lys Lys Gly Glu Ile Pro Lys 
865                 870     


<210> 5
<211> 1647
<212> DNA
<213> Mus musculus

<400> 5
agagaggagg aggaggagca ggcttgccgg tagcagggac agcatgggca atagcttgga       60

acaccgagtc ttgtcccggg atcaatccat ggacctggag gcaaagcagc tggactcggg      120

tatgtcctcg cccaacacca ccatgtcggt ccagccaatg acctttgacc tgggctcgcc      180

tactagcacg ttctccaact atgactcctg ctcctccagt cactccagca gcaaggggca      240

gcgatcgaat cgagggattc caggtgcaag agctgcagac ttacagagct acatggacat      300

gctgaaccca gagaagagct tgcctcgggg caagctaggg aagccttccc cgccaccacc      360

tccaccacca ccaccaccaa gcttcccgcc acccccacca cccacaggca cccagccgcc      420

cccacctcca ccaggctacc cagctcccaa tccccctgtg ggactgcatc tgaataacat      480

ttacatgcag accaagaaca agcttcgcca tgtggaggtg gactcgctca aggaggcggc      540

gctgctcccc gggaaccacg tgcacaacgg ctgctcagcg gactccaaag cgtccaggga      600

gctgccgccg ccaccgccgc cgccgccgct gcccgaggcc ctgagttcgc cgccgcccgc      660

cccacctctg cccatcgagg gcgcgggcgc agcctgcggg cagcgtcgtt cctcgtcttc      720

tactggcaaa gtgagagtcc tgagacacag gaagagcacc aaatctttca acatgatgtc      780

cccaacgggt gataactcag agcttctggc tgagataaag gcgggcaaga gcctgaagcc      840

gacaccgcag agcaaggggc tgacaaccgt gttctcaggc agtgggcagc cagcctccca      900

gcctgagtca ccgcagcctc tggtgtcacc tgcgccatct cggactcgga gccccacccc      960

gccagcctct gggtctcagc cactgctcaa tggcagtgtg gtgccggcac cacctgccac     1020

cccggcacct ggagtccatc tggatgtgga ggccctcatt cccactcttg atgagcaggg     1080

ccggcccatc ccggagtgga agcgccaggt gatggtccgc aagctgcagc agaagatgca     1140

ggaggaagag gagcagcgga ggaaggagga agaggaggag gcccggctcg ccagcctgcc     1200

tgcctggaga cgagacattc ttcggaagaa gctggaggag gagagggagc agaagcgaaa     1260

agaggaggag cggcaaaagc tggaggaaat acagagggcg aaagaacagt cggagaagct     1320

gcggacacta ggctacgacg aagccaagct cgcgccctgg cagcgacagg tcatcttgaa     1380

gaagggggag atccctaagt aataggagtc tctcggcttc ttgcgtgtag cctcacaagt     1440

tctgagagat ggggagcggc ccccagcccc cgccccatcc tgtcaggttg gtgcggaagg     1500

gctaggatcc ttgccgccct tcccttcggt gccggaaccc tcccaattcc cctccctggc     1560

cccacatccc caaccctgct gctggagtgc tctcgcaaac ccctgctgtc gcctggaaaa     1620

aagtgcccaa gctgctgacg caaaaag                                         1647


<210> 6
<211> 452
<212> PRT
<213> Mus musculus

<400> 6
Met Gly Asn Ser Leu Glu His Arg Val Leu Ser Arg Asp Gln Ser Met 
1               5                   10                  15      


Asp Leu Glu Ala Lys Gln Leu Asp Ser Gly Met Ser Ser Pro Asn Thr 
            20                  25                  30          


Thr Met Ser Val Gln Pro Met Thr Phe Asp Leu Gly Ser Pro Thr Ser 
        35                  40                  45              


Thr Phe Ser Asn Tyr Asp Ser Cys Ser Ser Ser His Ser Ser Ser Lys 
    50                  55                  60                  


Gly Gln Arg Ser Asn Arg Gly Ile Pro Gly Ala Arg Ala Ala Asp Leu 
65                  70                  75                  80  


Gln Ser Tyr Met Asp Met Leu Asn Pro Glu Lys Ser Leu Pro Arg Gly 
                85                  90                  95      


Lys Leu Gly Lys Pro Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Ser Phe Pro Pro Pro Pro Pro Pro Thr Gly Thr Gln Pro Pro Pro Pro 
        115                 120                 125             


Pro Pro Gly Tyr Pro Ala Pro Asn Pro Pro Val Gly Leu His Leu Asn 
    130                 135                 140                 


Asn Ile Tyr Met Gln Thr Lys Asn Lys Leu Arg His Val Glu Val Asp 
145                 150                 155                 160 


Ser Leu Lys Glu Ala Ala Leu Leu Pro Gly Asn His Val His Asn Gly 
                165                 170                 175     


Cys Ser Ala Asp Ser Lys Ala Ser Arg Glu Leu Pro Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Pro Leu Pro Glu Ala Leu Ser Ser Pro Pro Pro Ala Pro Pro 
        195                 200                 205             


Leu Pro Ile Glu Gly Ala Gly Ala Ala Cys Gly Gln Arg Arg Ser Ser 
    210                 215                 220                 


Ser Ser Thr Gly Lys Val Arg Val Leu Arg His Arg Lys Ser Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser Glu Leu Leu Ala 
                245                 250                 255     


Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro Gln Ser Lys Gly 
            260                 265                 270         


Leu Thr Thr Val Phe Ser Gly Ser Gly Gln Pro Ala Ser Gln Pro Glu 
        275                 280                 285             


Ser Pro Gln Pro Leu Val Ser Pro Ala Pro Ser Arg Thr Arg Ser Pro 
    290                 295                 300                 


Thr Pro Pro Ala Ser Gly Ser Gln Pro Leu Leu Asn Gly Ser Val Val 
305                 310                 315                 320 


Pro Ala Pro Pro Ala Thr Pro Ala Pro Gly Val His Leu Asp Val Glu 
                325                 330                 335     


Ala Leu Ile Pro Thr Leu Asp Glu Gln Gly Arg Pro Ile Pro Glu Trp 
            340                 345                 350         


Lys Arg Gln Val Met Val Arg Lys Leu Gln Gln Lys Met Gln Glu Glu 
        355                 360                 365             


Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala Arg Leu Ala Ser 
    370                 375                 380                 


Leu Pro Ala Trp Arg Arg Asp Ile Leu Arg Lys Lys Leu Glu Glu Glu 
385                 390                 395                 400 


Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys Leu Glu Glu Ile 
                405                 410                 415     


Gln Arg Ala Lys Glu Gln Ser Glu Lys Leu Arg Thr Leu Gly Tyr Asp 
            420                 425                 430         


Glu Ala Lys Leu Ala Pro Trp Gln Arg Gln Val Ile Leu Lys Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys 
    450         


<210> 7
<211> 3322
<212> DNA
<213> Rattus norvegicus

<400> 7
gccgagggtg acaccatggc cctggaacag gcgatgcagg cggcacggcg gggcgacctg       60

gacgtgctga ggtccctgca cgccgccggc ctgctggggc cttctctgcg cgacccgcta      120

gacgccctgc cggtgcacca tgcggcccgc tcaggcaagc tgcactgttt gcgctacttg      180

gtggaggagg ttgccctccc agctgtgtcc cgcgcgcgca acggcgccac accagcccat      240

gatgccgctg ccacgggcta cctctcttgc ctgcagtggc tgctcacaca gggtggctgc      300

agggtgcagg aaaaagataa ctctggtgcc acggtcctgc acctggctgc ccgctttggc      360

cacccggacg tggtgaactg gctgctgtac cagggcggtg cgaactctgc catcaccaca      420

gacacgggcg ccctgcctat ccactatgct gccgccaaag gagatctccc ctccatgaag      480

cttcttgtcg ggcactaccc tgagggagtg aatgcccaaa ccaacaacgg tgccacgccc      540

ctgtacctgg cgtgccagga gggccacctg gaagtgacga agtaccttgt gcaggagtgc      600

agtgcagatc cgcacctgcg cgcccaagac ggcatgaccc ccctgcatgc cgcggcgcag      660

atgggccaca acccagtcct ggtgtggctg gtgagctttg cggacgtgag cttttcggag      720

caggaccacg acggcgccac agccatgcac tttgcagcca gccgcggcca caccaaagtg      780

ctcagctggc tcctgctgca cggcgcagag atctcccagg acctgtgggg cgggaccccg      840

ctgcatgatg ctgctgagaa cggggaactg gagtgctgcc agatcctcgc ggtgaatggt      900

gcggggctgg acgtccgcga ccacgatggg tatacggctg cggacctggc tgatttcaat      960

ggccacaccc actgctcccg ctacctacgt acggtgcaaa ccctgagctt ggaacaccga     1020

gtcctgtccc gggatccatc catggacctg gaggcaaagc agccggactc aggcatgtct     1080

tcacccaaca ccaccatgtc ggtccagccg ccgaactttg accttggctc acccaccagc     1140

accctctcca actatgactc ctgctcctcc agccattcca gcagcaaggg tcagcgctct     1200

actcgaggtg ccagatcctc agacttacag agctacatgg acatgctgaa cccagagcct     1260

cggagcaagc aagggaagcc ttcatctcta ccaccaccgc caccaccaag cttccctcca     1320

ccaccacccc caggcacaca gctgccccca cctccaccag gctacccagc tcccaatccc     1380

cctgtggggc tgcatttgga taacatttac atgcagacca agaacaaact ccgccacgtg     1440

gaggtggact ccctcaagaa ggagccgagc tccggcgacg gctactcggg gctacgcagg     1500

caggattccg ggctgctcag gcaggattcg gagctgctgc tcaggcacaa caccggactg     1560

cgcaggcagg actccgaccg caaacagcgt tcattcagta aacagcccag cacgggggac     1620

tactaccgcc agctgggccg cagcccgggg gagccgctgg ccgcacgccc gggcatggcc     1680

cacagcgagg aggcggcgct gctccccggg aaccacgtgc acaacggctg ctccgcggac     1740

tccaaagcgt ccagggagct gccgccgcca ccgccgccgc cgcccctgcc cgaggccctg     1800

agttcgccgc cacccgcccc acctctgccc atcgagggcg cgggcgcagc ctgcggacag     1860

cggcgttcct catcttctac tggcagcacc aaatctttca acatgatgtc cccaacgggt     1920

gacaactcgg agttgctggc tgaaataaaa gcaggcaaga gtctgaaacc aacaccgcag     1980

agcaaggggc tgacaacagt gttctcaggc agcgggcagc cagcctccca gcctgagtca     2040

ccacagcctg cggtgtcacc tgggccatct cgggcccgga gccccacccc accagcctct     2100

gggcctcagc cactgctcaa tggcagcata gtaccggcac cacctgccac cctagcacca     2160

ggagtgcatc tggatgtgga ggccctcatc cccacacttg atgagcaggg ccggcccatc     2220

ccggagtgga agcgccaggt gatggtccgg aagctgcagc agaaaatgca ggaggaagag     2280

gagcagcgga ggaaggaaga agaggaggag gcccggctgg ccagcctgcc cgcctggaga     2340

cgagacattc ttaggaagaa gctggaggag gagagggagc agaagcgaaa agaggaggag     2400

cggcagaagc tggaggaaat ccagagggcg aaagaacagt cggagaagct gcggacacta     2460

ggatacgacg aggccaagct cgcgccctgg cagcgacagg tcatcttgaa gaagggggag     2520

atccctaagt aataggagtc tcggcctctt gcgtgtagcc tcacgagctc tgagaaatgg     2580

ggagcggccc ccagcccccg ccccatcctg tcaggttggt gcggaagggt gggagccttg     2640

agcccttccc ttcggtgcct gccggaatct tccctattcc cctccctggc cccacatccc     2700

caaccctgct gctggagtgc tctcgcgaac ccctgctgtc gcctggaaaa aaaaagtgcc     2760

caggctgctg acgcaaaaag aaaaaaagag aaagaaaaaa gatgctcatt tgcatgctca     2820

cttacatata tttgcatgtt caccgaccca gccggagctc gccccagcct cgtgggtggt     2880

gacttttcct gcagggcgca cgccctgctg cagccccctc ccccgcagcc cggaacccac     2940

attgctggcg catcctgggt ggaggcagac cccgagctcg gggaaggggt tttcctccct     3000

ccacgaccca gatctgtgct ggccaaagtt gctgcgtttc ttatcccctg cgagggtttc     3060

ctctcagtca tttgtttacc agaaaggatg aaacttgcct gtaggggcgg agctgtcgct     3120

cctgaggggc cccaccttta cacgtaccac cccctccccc cgccccagtt acgccttcca     3180

agttcccagt caggccctta gcttccctga ccctttcact gcctcaatgg tataagtgga     3240

gggccaggga tcccgcaatt gtacctgctc ctcaccctat cccccacccc cttccttccc     3300

ccattaaacc tctatccgcc aa                                              3322


<210> 8
<211> 838
<212> PRT
<213> Rattus norvegicus

<400> 8
Met Ala Leu Glu Gln Ala Met Gln Ala Ala Arg Arg Gly Asp Leu Asp 
1               5                   10                  15      


Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg 
            20                  25                  30          


Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ser Gly Lys 
        35                  40                  45              


Leu His Cys Leu Arg Tyr Leu Val Glu Glu Val Ala Leu Pro Ala Val 
    50                  55                  60                  


Ser Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ala Ala Thr 
65                  70                  75                  80  


Gly Tyr Leu Ser Cys Leu Gln Trp Leu Leu Thr Gln Gly Gly Cys Arg 
                85                  90                  95      


Val Gln Glu Lys Asp Asn Ser Gly Ala Thr Val Leu His Leu Ala Ala 
            100                 105                 110         


Arg Phe Gly His Pro Asp Val Val Asn Trp Leu Leu Tyr Gln Gly Gly 
        115                 120                 125             


Ala Asn Ser Ala Ile Thr Thr Asp Thr Gly Ala Leu Pro Ile His Tyr 
    130                 135                 140                 


Ala Ala Ala Lys Gly Asp Leu Pro Ser Met Lys Leu Leu Val Gly His 
145                 150                 155                 160 


Tyr Pro Glu Gly Val Asn Ala Gln Thr Asn Asn Gly Ala Thr Pro Leu 
                165                 170                 175     


Tyr Leu Ala Cys Gln Glu Gly His Leu Glu Val Thr Lys Tyr Leu Val 
            180                 185                 190         


Gln Glu Cys Ser Ala Asp Pro His Leu Arg Ala Gln Asp Gly Met Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Gln Met Gly His Asn Pro Val Leu Val Trp 
    210                 215                 220                 


Leu Val Ser Phe Ala Asp Val Ser Phe Ser Glu Gln Asp His Asp Gly 
225                 230                 235                 240 


Ala Thr Ala Met His Phe Ala Ala Ser Arg Gly His Thr Lys Val Leu 
                245                 250                 255     


Ser Trp Leu Leu Leu His Gly Ala Glu Ile Ser Gln Asp Leu Trp Gly 
            260                 265                 270         


Gly Thr Pro Leu His Asp Ala Ala Glu Asn Gly Glu Leu Glu Cys Cys 
        275                 280                 285             


Gln Ile Leu Ala Val Asn Gly Ala Gly Leu Asp Val Arg Asp His Asp 
    290                 295                 300                 


Gly Tyr Thr Ala Ala Asp Leu Ala Asp Phe Asn Gly His Thr His Cys 
305                 310                 315                 320 


Ser Arg Tyr Leu Arg Thr Val Gln Thr Leu Ser Leu Glu His Arg Val 
                325                 330                 335     


Leu Ser Arg Asp Pro Ser Met Asp Leu Glu Ala Lys Gln Pro Asp Ser 
            340                 345                 350         


Gly Met Ser Ser Pro Asn Thr Thr Met Ser Val Gln Pro Pro Asn Phe 
        355                 360                 365             


Asp Leu Gly Ser Pro Thr Ser Thr Leu Ser Asn Tyr Asp Ser Cys Ser 
    370                 375                 380                 


Ser Ser His Ser Ser Ser Lys Gly Gln Arg Ser Thr Arg Gly Ala Arg 
385                 390                 395                 400 


Ser Ser Asp Leu Gln Ser Tyr Met Asp Met Leu Asn Pro Glu Pro Arg 
                405                 410                 415     


Ser Lys Gln Gly Lys Pro Ser Ser Leu Pro Pro Pro Pro Pro Pro Ser 
            420                 425                 430         


Phe Pro Pro Pro Pro Pro Pro Gly Thr Gln Leu Pro Pro Pro Pro Pro 
        435                 440                 445             


Gly Tyr Pro Ala Pro Asn Pro Pro Val Gly Leu His Leu Asp Asn Ile 
    450                 455                 460                 


Tyr Met Gln Thr Lys Asn Lys Leu Arg His Val Glu Val Asp Ser Leu 
465                 470                 475                 480 


Lys Lys Glu Pro Ser Ser Gly Asp Gly Tyr Ser Gly Leu Arg Arg Gln 
                485                 490                 495     


Asp Ser Gly Leu Leu Arg Gln Asp Ser Glu Leu Leu Leu Arg His Asn 
            500                 505                 510         


Thr Gly Leu Arg Arg Gln Asp Ser Asp Arg Lys Gln Arg Ser Phe Ser 
        515                 520                 525             


Lys Gln Pro Ser Thr Gly Asp Tyr Tyr Arg Gln Leu Gly Arg Ser Pro 
    530                 535                 540                 


Gly Glu Pro Leu Ala Ala Arg Pro Gly Met Ala His Ser Glu Glu Ala 
545                 550                 555                 560 


Ala Leu Leu Pro Gly Asn His Val His Asn Gly Cys Ser Ala Asp Ser 
                565                 570                 575     


Lys Ala Ser Arg Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
            580                 585                 590         


Glu Ala Leu Ser Ser Pro Pro Pro Ala Pro Pro Leu Pro Ile Glu Gly 
        595                 600                 605             


Ala Gly Ala Ala Cys Gly Gln Arg Arg Ser Ser Ser Ser Thr Gly Ser 
    610                 615                 620                 


Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser Glu Leu 
625                 630                 635                 640 


Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro Gln Ser 
                645                 650                 655     


Lys Gly Leu Thr Thr Val Phe Ser Gly Ser Gly Gln Pro Ala Ser Gln 
            660                 665                 670         


Pro Glu Ser Pro Gln Pro Ala Val Ser Pro Gly Pro Ser Arg Ala Arg 
        675                 680                 685             


Ser Pro Thr Pro Pro Ala Ser Gly Pro Gln Pro Leu Leu Asn Gly Ser 
    690                 695                 700                 


Ile Val Pro Ala Pro Pro Ala Thr Leu Ala Pro Gly Val His Leu Asp 
705                 710                 715                 720 


Val Glu Ala Leu Ile Pro Thr Leu Asp Glu Gln Gly Arg Pro Ile Pro 
                725                 730                 735     


Glu Trp Lys Arg Gln Val Met Val Arg Lys Leu Gln Gln Lys Met Gln 
            740                 745                 750         


Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala Arg Leu 
        755                 760                 765             


Ala Ser Leu Pro Ala Trp Arg Arg Asp Ile Leu Arg Lys Lys Leu Glu 
    770                 775                 780                 


Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys Leu Glu 
785                 790                 795                 800 


Glu Ile Gln Arg Ala Lys Glu Gln Ser Glu Lys Leu Arg Thr Leu Gly 
                805                 810                 815     


Tyr Asp Glu Ala Lys Leu Ala Pro Trp Gln Arg Gln Val Ile Leu Lys 
            820                 825                 830         


Lys Gly Glu Ile Pro Lys 
        835             


<210> 9
<211> 1563
<212> DNA
<213> Rattus norvegicus

<400> 9
atgggtgata gcttggaaca ccgagtcctg tcccgggatc catccatgga cctggaggca       60

aagcagccgg actcaggcat gtcttcaccc aacaccacca tgtcggtcca gccgccgaac      120

tttgaccttg gctcacccac cagcaccctc tccaactatg actcctgctc ctccagccat      180

tccagcagca agggtcagcg ctctactcga ggtgccagat cctcagactt acagagctac      240

atggacatgc tgaacccaga gcctcggagc aagcaaggga agccttcatc tctaccacca      300

ccgccaccac caagcttccc tccaccacca cccccaggca cacagctgcc cccacctcca      360

ccaggctacc cagctcccaa tccccctgtg gggctgcatt tggataacat ttacatgcag      420

accaagaaca aactccgcca cgtggaggtg gactccctca agaaggagcc gagctccggc      480

gacggctact cggggctacg caggcaggat tccgggctgc tcaggcagga ttcggagctg      540

ctgctcaggc acaacaccgg actgcgcagg caggactccg accgcaaaca gcgttcattc      600

agtaaacagc ccagcacggg ggactactac cgccagctgg gccgcagccc gggggagccg      660

ctggccgcac gcccgggcat ggcccacagc gaggaggcgg cgctgctccc cgggaaccac      720

gtgcacaacg gctgctccgc ggactccaaa gcgtccaggg agctgccgcc gccaccgccg      780

ccgccgcccc tgcccgaggc cctgagttcg ccgccacccg ccccacctct gcccatcgag      840

ggcgcgggcg cagcctgcgg acagcggcgt tcctcatctt ctactggcaa agtgagaatc      900

ctgagacaca ggaagagcac caaatctttc aacatgatgt ccccaacggg tgacaactcg      960

gagttgctgg ctgaaataaa agcaggcaag agtctgaaac caacaccgca gagcaagggg     1020

ctgacaacag tgttctcagg cagcgggcag ccagcctccc agcctgagtc accacagcct     1080

gcggtgtcac ctgggccatc tcgggcccgg agccccaccc caccagcctc tgggcctcag     1140

ccactgctca atggcagcat agtaccggca ccacctgcca ccctagcacc aggagtgcat     1200

ctggatgtgg aggccctcat ccccacactt gatgagcagg gccggcccat cccggagtgg     1260

aagcgccagg tgatggtccg gaagctgcag cagaaaatgc aggaggaaga ggagcagcgg     1320

aggaaggaag aagaggagga ggcccggctg gccagcctgc ccgcctggag acgagacatt     1380

cttaggaaga agctggagga ggagagggag cagaagcgaa aagaggagga gcggcagaag     1440

ctggaggaaa tccagagggc gaaagaacag tcggagaagc tgcggacact aggatacgac     1500

gaggccaagc tcgcgccctg gcagcgacag gtcatcttga agaaggggga gatccctaag     1560

taa                                                                   1563


<210> 10
<211> 520
<212> PRT
<213> Rattus norvegicus

<400> 10
Met Gly Asp Ser Leu Glu His Arg Val Leu Ser Arg Asp Pro Ser Met 
1               5                   10                  15      


Asp Leu Glu Ala Lys Gln Pro Asp Ser Gly Met Ser Ser Pro Asn Thr 
            20                  25                  30          


Thr Met Ser Val Gln Pro Pro Asn Phe Asp Leu Gly Ser Pro Thr Ser 
        35                  40                  45              


Thr Leu Ser Asn Tyr Asp Ser Cys Ser Ser Ser His Ser Ser Ser Lys 
    50                  55                  60                  


Gly Gln Arg Ser Thr Arg Gly Ala Arg Ser Ser Asp Leu Gln Ser Tyr 
65                  70                  75                  80  


Met Asp Met Leu Asn Pro Glu Pro Arg Ser Lys Gln Gly Lys Pro Ser 
                85                  90                  95      


Ser Leu Pro Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Gly Thr Gln Leu Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Asn Pro 
        115                 120                 125             


Pro Val Gly Leu His Leu Asp Asn Ile Tyr Met Gln Thr Lys Asn Lys 
    130                 135                 140                 


Leu Arg His Val Glu Val Asp Ser Leu Lys Lys Glu Pro Ser Ser Gly 
145                 150                 155                 160 


Asp Gly Tyr Ser Gly Leu Arg Arg Gln Asp Ser Gly Leu Leu Arg Gln 
                165                 170                 175     


Asp Ser Glu Leu Leu Leu Arg His Asn Thr Gly Leu Arg Arg Gln Asp 
            180                 185                 190         


Ser Asp Arg Lys Gln Arg Ser Phe Ser Lys Gln Pro Ser Thr Gly Asp 
        195                 200                 205             


Tyr Tyr Arg Gln Leu Gly Arg Ser Pro Gly Glu Pro Leu Ala Ala Arg 
    210                 215                 220                 


Pro Gly Met Ala His Ser Glu Glu Ala Ala Leu Leu Pro Gly Asn His 
225                 230                 235                 240 


Val His Asn Gly Cys Ser Ala Asp Ser Lys Ala Ser Arg Glu Leu Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu Ala Leu Ser Ser Pro Pro 
            260                 265                 270         


Pro Ala Pro Pro Leu Pro Ile Glu Gly Ala Gly Ala Ala Cys Gly Gln 
        275                 280                 285             


Arg Arg Ser Ser Ser Ser Thr Gly Lys Val Arg Ile Leu Arg His Arg 
    290                 295                 300                 


Lys Ser Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser 
305                 310                 315                 320 


Glu Leu Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro 
                325                 330                 335     


Gln Ser Lys Gly Leu Thr Thr Val Phe Ser Gly Ser Gly Gln Pro Ala 
            340                 345                 350         


Ser Gln Pro Glu Ser Pro Gln Pro Ala Val Ser Pro Gly Pro Ser Arg 
        355                 360                 365             


Ala Arg Ser Pro Thr Pro Pro Ala Ser Gly Pro Gln Pro Leu Leu Asn 
    370                 375                 380                 


Gly Ser Ile Val Pro Ala Pro Pro Ala Thr Leu Ala Pro Gly Val His 
385                 390                 395                 400 


Leu Asp Val Glu Ala Leu Ile Pro Thr Leu Asp Glu Gln Gly Arg Pro 
                405                 410                 415     


Ile Pro Glu Trp Lys Arg Gln Val Met Val Arg Lys Leu Gln Gln Lys 
            420                 425                 430         


Met Gln Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala 
        435                 440                 445             


Arg Leu Ala Ser Leu Pro Ala Trp Arg Arg Asp Ile Leu Arg Lys Lys 
    450                 455                 460                 


Leu Glu Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys 
465                 470                 475                 480 


Leu Glu Glu Ile Gln Arg Ala Lys Glu Gln Ser Glu Lys Leu Arg Thr 
                485                 490                 495     


Leu Gly Tyr Asp Glu Ala Lys Leu Ala Pro Trp Gln Arg Gln Val Ile 
            500                 505                 510         


Leu Lys Lys Gly Glu Ile Pro Lys 
        515                 520 


