                               SEQUENCE LISTING

<110> JANSSEN PHARMACEUTICA NV

<120> ANTI- GPRC5D ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES 
      THAT BIND GPRC5D AND CD3, AND USES THEREOF

<130> PRD3422WOPCT

<140>
<141>

<150> 62/364,811
<151> 2016-07-20

<160> 100   

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Homo sapiens

<400> 1
Ser Tyr Ala Ile Ser 
1               5   


<210> 2
<211> 5
<212> PRT
<213> Homo sapiens

<400> 2
Asn Tyr Trp Met Ser 
1               5   


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens

<400> 3
Ser Tyr Phe Ile Gly 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Homo sapiens

<400> 4
Gly Tyr Thr Met Asn 
1               5   


<210> 5
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 17
<212> PRT
<213> Homo sapiens

<400> 6
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Ser Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 7
<211> 17
<212> PRT
<213> Homo sapiens

<400> 7
Ile Ile Tyr Pro Gly Lys Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 8
<211> 17
<212> PRT
<213> Homo sapiens

<400> 8
Leu Ile Asn Pro Tyr Asn Ser Asp Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 9
<211> 10
<212> PRT
<213> Homo sapiens

<400> 9
Glu Ser Arg Trp Arg Gly Tyr Lys Leu Asp 
1               5                   10  


<210> 10
<211> 13
<212> PRT
<213> Homo sapiens

<400> 10
Ala Ala Phe Asp Phe Gly Arg Arg Ala Val Arg Leu Asp 
1               5                   10              


<210> 11
<211> 14
<212> PRT
<213> Homo sapiens

<400> 11
Val Tyr Ser Phe Gly Gly Arg His Lys Ala Leu Phe Asp Tyr 
1               5                   10                  


<210> 12
<211> 9
<212> PRT
<213> Homo sapiens

<400> 12
Val Ala Leu Arg Val Ala Leu Asp Tyr 
1               5                   


<210> 13
<211> 11
<212> PRT
<213> Homo sapiens

<400> 13
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 14
<211> 11
<212> PRT
<213> Homo sapiens

<400> 14
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 15
<211> 11
<212> PRT
<213> Homo sapiens

<400> 15
Lys Ala Ser Gln Asn Val Ala Thr His Val Gly 
1               5                   10      


<210> 16
<211> 7
<212> PRT
<213> Homo sapiens

<400> 16
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 17
<211> 7
<212> PRT
<213> Homo sapiens

<400> 17
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 18
<211> 7
<212> PRT
<213> Homo sapiens

<400> 18
Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210> 19
<211> 9
<212> PRT
<213> Homo sapiens

<400> 19
Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210> 20
<211> 9
<212> PRT
<213> Homo sapiens

<400> 20
Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210> 21
<211> 9
<212> PRT
<213> Homo sapiens

<400> 21
Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr 
1               5                   


<210> 22
<211> 345
<212> PRT
<213> Homo sapiens

<400> 22
Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 
1               5                   10                  15      


Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 
    50                  55                  60                  


Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 
        115                 120                 125             


Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 
    130                 135                 140                 


Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 
145                 150                 155                 160 


Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 
        195                 200                 205             


Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 
225                 230                 235                 240 


Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 
                245                 250                 255     


Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 
        275                 280                 285             


Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr Pro Ile Gln Pro 
305                 310                 315                 320 


Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Gly Val 
            340                 345 


<210> 23
<211> 344
<212> PRT
<213> Macaca fascicularis

<400> 23
Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Pro Cys 
1               5                   10                  15      


Asp Ser Glu Gly Pro Trp Gly Ile Val Leu Glu Ser Leu Ala Ile Leu 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 
    50                  55                  60                  


Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Gln Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Arg Val Ser Phe Ser Trp Thr Thr 
        115                 120                 125             


Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Val Ile Ile Ala 
    130                 135                 140                 


Ile Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val His 
145                 150                 155                 160 


Met Thr Pro Tyr Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 
        195                 200                 205             


Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 
225                 230                 235                 240 


Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 
                245                 250                 255     


Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Ser Gln Gly His Ala Cys Pro Val Thr Ala Tyr Gln Arg Ser 
        275                 280                 285             


Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Glu Glu Asp Val Ala Leu Thr Ser Phe Gly Thr Pro Ile Gln Pro 
305                 310                 315                 320 


Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Arg Ala Lys Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Val 
            340                 


<210> 24
<211> 344
<212> PRT
<213> Mus sp.

<400> 24
Met Tyr Glu Asp Cys Val Lys Ser Thr Glu Asp Tyr Tyr Leu Phe Cys 
1               5                   10                  15      


Asp Asn Glu Gly Pro Trp Ala Ile Val Leu Glu Ser Leu Ala Val Ile 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Val Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Phe 
    50                  55                  60                  


Leu Phe Leu Leu Ala Val Leu Gly Leu Phe Gly Leu Thr Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Gln Leu Asn His Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Ile Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Arg Val Ser Phe Cys Trp Thr Thr 
        115                 120                 125             


Ile Leu Phe Ile Ala Ile Gly Val Ser Leu Leu Gln Thr Ile Ile Ala 
    130                 135                 140                 


Ile Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Leu Met Phe Glu His 
145                 150                 155                 160 


Met Thr Pro Tyr Gln Leu Asn Val Asp Phe Val Cys Leu Leu Ile Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ala 
        195                 200                 205             


Thr Val Leu Val Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Leu Gln Arg Gln Pro His Trp Asp Asp Ala 
225                 230                 235                 240 


Val Ile Cys Ile Gly Leu Val Thr Asn Ala Trp Val Phe Leu Leu Ile 
                245                 250                 255     


Tyr Ile Ile Pro Glu Leu Ser Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Thr Gln Gly Asn Val Cys Gln Val Pro Val Tyr Gln Arg Ser 
        275                 280                 285             


Phe Arg Met Asp Thr Gln Glu Pro Thr Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Gln Glu Asp Val Ala Leu Thr Ala Tyr Gly Thr Pro Ile Gln Leu 
305                 310                 315                 320 


Gln Ser Ala Asp Pro Ser Arg Glu Tyr Leu Ile Pro Ser Ala Thr Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Leu 
            340                 


<210> 25
<211> 125
<212> PRT
<213> Homo sapiens

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 26
<211> 109
<212> PRT
<213> Homo sapiens

<400> 26
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 27
<211> 5
<212> PRT
<213> Homo sapiens

<400> 27
Ser Tyr Trp Ile Gly 
1               5   


<210> 28
<211> 17
<212> PRT
<213> Homo sapiens

<400> 28
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 29
<211> 17
<212> PRT
<213> Homo sapiens

<400> 29
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 30
<211> 14
<212> PRT
<213> Homo sapiens

<400> 30
Ala Ala Trp Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 31
<211> 11
<212> PRT
<213> Homo sapiens

<400> 31
Glu Ser Arg Tyr Arg Gly Tyr Lys Leu Asp Tyr 
1               5                   10      


<210> 32
<211> 11
<212> PRT
<213> Homo sapiens

<400> 32
Glu Ser Arg Val Arg Gly Tyr Lys Leu Asp Tyr 
1               5                   10      


<210> 33
<211> 11
<212> PRT
<213> Homo sapiens

<400> 33
Glu Ser Arg Gly Arg Gly Tyr Lys Leu Asp Tyr 
1               5                   10      


<210> 34
<211> 11
<212> PRT
<213> Homo sapiens

<400> 34
Glu Ser Arg Ala Arg Gly Tyr Lys Leu Asp Tyr 
1               5                   10      


<210> 35
<211> 11
<212> PRT
<213> Homo sapiens

<400> 35
Glu Ser Arg Phe Arg Gly Tyr Lys Leu Asp Tyr 
1               5                   10      


<210> 36
<211> 5
<212> PRT
<213> Homo sapiens

<400> 36
Ser Tyr Tyr Ile Gly 
1               5   


<210> 37
<211> 5
<212> PRT
<213> Homo sapiens

<400> 37
Ser Tyr Val Ile Gly 
1               5   


<210> 38
<211> 5
<212> PRT
<213> Homo sapiens

<400> 38
Ser Tyr Gly Ile Gly 
1               5   


<210> 39
<211> 5
<212> PRT
<213> Homo sapiens

<400> 39
Ser Tyr Ala Ile Gly 
1               5   


<210> 40
<211> 17
<212> PRT
<213> Homo sapiens

<400> 40
Ile Ile Tyr Pro Gly Ala Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 41
<211> 17
<212> PRT
<213> Homo sapiens

<400> 41
Ile Ile Tyr Pro Gly Ser Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 42
<211> 17
<212> PRT
<213> Homo sapiens

<400> 42
Ile Ile Tyr Pro Gly Glu Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 43
<211> 17
<212> PRT
<213> Homo sapiens

<400> 43
Ile Ile Tyr Pro Gly Tyr Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 44
<211> 17
<212> PRT
<213> Homo sapiens

<400> 44
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 45
<211> 17
<212> PRT
<213> Homo sapiens

<400> 45
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Lys Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 46
<211> 17
<212> PRT
<213> Homo sapiens

<400> 46
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 47
<211> 17
<212> PRT
<213> Homo sapiens

<400> 47
Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Tyr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 48
<211> 14
<212> PRT
<213> Homo sapiens

<400> 48
Ala Ala Tyr Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 49
<211> 14
<212> PRT
<213> Homo sapiens

<400> 49
Ala Ala Val Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 50
<211> 14
<212> PRT
<213> Homo sapiens

<400> 50
Ala Ala Gly Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 51
<211> 14
<212> PRT
<213> Homo sapiens

<400> 51
Ala Ala Ala Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 52
<211> 120
<212> PRT
<213> Homo sapiens

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Arg Trp Arg Gly Tyr Lys Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 53
<211> 123
<212> PRT
<213> Homo sapiens

<400> 53
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Phe Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 54
<211> 123
<212> PRT
<213> Homo sapiens

<400> 54
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Lys Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr Ser Phe Gly Gly Arg His Lys Ala Leu Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 55
<211> 118
<212> PRT
<213> Homo sapiens

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ser Asp Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Leu Arg Val Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 56
<211> 107
<212> PRT
<213> Homo sapiens

<400> 56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 57
<211> 107
<212> PRT
<213> Homo sapiens

<400> 57
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 58
<211> 107
<212> PRT
<213> Homo sapiens

<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Ala Thr His 
            20                  25                  30          


Val Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 59
<211> 327
<212> PRT
<213> Homo sapiens

<400> 59
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 60
<211> 330
<212> PRT
<213> Homo sapiens

<400> 60
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 61
<211> 5
<212> PRT
<213> Homo sapiens

<400> 61
Asp Tyr Gly Met His 
1               5   


<210> 62
<211> 5
<212> PRT
<213> Homo sapiens

<400> 62
Gly Tyr Ala Met Ser 
1               5   


<210> 63
<211> 5
<212> PRT
<213> Homo sapiens

<400> 63
Ser Tyr Gly Ile Ser 
1               5   


<210> 64
<211> 10
<212> PRT
<213> Homo sapiens

<400> 64
Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210> 65
<211> 5
<212> PRT
<213> Homo sapiens

<400> 65
Ser Tyr Ala Met Ser 
1               5   


<210> 66
<211> 10
<212> PRT
<213> Homo sapiens

<400> 66
Gly Phe Ser Leu Thr Ser Tyr Asn Val His 
1               5                   10  


<210> 67
<211> 17
<212> PRT
<213> Homo sapiens

<400> 67
Ala Ile Lys Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 68
<211> 17
<212> PRT
<213> Homo sapiens

<400> 68
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 69
<211> 17
<212> PRT
<213> Homo sapiens

<400> 69
Gly Ile Ile Pro Ile Phe Gly Asn Ile Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 70
<211> 10
<212> PRT
<213> Homo sapiens

<400> 70
Leu Ile Asn Pro Tyr Asn Gly Asp Thr Asn 
1               5                   10  


<210> 71
<211> 16
<212> PRT
<213> Homo sapiens

<400> 71
Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210> 72
<211> 10
<212> PRT
<213> Homo sapiens

<400> 72
Arg Ala Glu Ser Gly Pro Gly Leu Asp Tyr 
1               5                   10  


<210> 73
<211> 13
<212> PRT
<213> Homo sapiens

<400> 73
Ile Gly Phe Tyr Gly Arg Ser Phe Arg Ile Phe Asp Tyr 
1               5                   10              


<210> 74
<211> 14
<212> PRT
<213> Homo sapiens

<400> 74
Val Asp Arg Ser Phe Gly Arg Ser Arg Tyr Thr Leu Asp Tyr 
1               5                   10                  


<210> 75
<211> 14
<212> PRT
<213> Homo sapiens

<400> 75
Val Ser Arg Arg Phe Lys Arg Phe Ala Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210> 76
<211> 10
<212> PRT
<213> Homo sapiens

<400> 76
Ser Asn Phe Leu Pro Val Val Phe Asp Tyr 
1               5                   10  


<210> 77
<211> 9
<212> PRT
<213> Homo sapiens

<400> 77
Asp Gly Ile Arg Leu Arg Phe Ala Tyr 
1               5                   


<210> 78
<211> 7
<212> PRT
<213> Homo sapiens

<400> 78
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 79
<211> 7
<212> PRT
<213> Homo sapiens

<400> 79
Thr Ala Ser Asn Arg Ala Thr 
1               5           


<210> 80
<211> 9
<212> PRT
<213> Homo sapiens

<400> 80
Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210> 81
<211> 9
<212> PRT
<213> Homo sapiens

<400> 81
Gln Gln Tyr Phe Arg Ala Pro Ile Thr 
1               5                   


<210> 82
<211> 119
<212> PRT
<213> Homo sapiens

<400> 82
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ala Glu Ser Gly Pro Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 83
<211> 123
<212> PRT
<213> Homo sapiens

<400> 83
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Trp Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 84
<211> 122
<212> PRT
<213> Homo sapiens

<400> 84
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Gly Phe Tyr Gly Arg Ser Phe Arg Ile Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 85
<211> 123
<212> PRT
<213> Homo sapiens

<400> 85
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr Ser Phe Gly Gly Arg His Lys Ala Leu Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 86
<211> 123
<212> PRT
<213> Homo sapiens

<400> 86
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Arg Ser Phe Gly Arg Ser Arg Tyr Thr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 87
<211> 123
<212> PRT
<213> Homo sapiens

<400> 87
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Asn Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Arg Arg Phe Lys Arg Phe Ala Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 88
<211> 118
<212> PRT
<213> Homo sapiens

<400> 88
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Leu Arg Val Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 89
<211> 119
<212> PRT
<213> Homo sapiens

<400> 89
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Phe Leu Pro Val Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 90
<211> 705
<212> DNA
<213> Homo sapiens

<400> 90
atgcgggtgc tggcccagct gctgggactg ctgctgctgt gcttccctgg cgccagatgc       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgca aggccagcca gaacgtggcc acccacgtgg gctggtacca gcagaagccc      180

ggcaaggccc ccaagcggct gatctacagc gccagctacc ggtacagcgg cgtgcccagc      240

cggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcaa cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tacaaccggt acccctacac cttcggccag      360

ggcaccaagc tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210> 91
<211> 117
<212> PRT
<213> Homo sapiens

<400> 91
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Ile Arg Leu Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 92
<211> 113
<212> PRT
<213> Homo sapiens

<400> 92
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 93
<211> 108
<212> PRT
<213> Homo sapiens

<400> 93
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Lys Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Phe Arg Ala Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Lys 
            100                 105             


<210> 94
<211> 107
<212> PRT
<213> Homo sapiens

<400> 94
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Ala Thr His 
            20                  25                  30          


Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 95
<211> 11
<212> PRT
<213> Homo sapiens

<400> 95
Arg Ala Ser Gln Ser Val Arg Lys Ser Leu Ala 
1               5                   10      


<210> 96
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 96
atggcctggg tctggaccct gctgttcctg atggccgctg cccagagcat ccaggcccag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgccagcgt gaaggtgagc      120

tgcaaggcca gcggctacag cttcaccggc tacaccatga actgggtgcg gcaggccccc      180

ggccagggcc tggagtggat gggcctgatc aacccctaca acagcgacac caactacgcc      240

cagaagctgc agggccgggt gaccatgacc accgacacca gcaccagcac cgcctacatg      300

gagctgcgga gcctgcggag cgacgacacc gccgtgtact actgcgcccg ggtggccctg      360

cgggtggccc tggactactg gggccagggc accctggtga ccgtgagcag cgcctccacc      420

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaaaac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      720

cccccatgcc caccatgccc agcacctgag gccgccgggg gaccatcagt cttcctgttc      780

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      840

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     1020

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1380

tctctgggta aatga                                                      1395


<210> 97
<211> 14
<212> PRT
<213> Homo sapiens

<400> 97
Ala Ala Phe Asp Phe Gly Arg Arg Ala Val Arg Leu Asp Tyr 
1               5                   10                  


<210> 98
<211> 17
<212> PRT
<213> Homo sapiens

<400> 98
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 99
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 99
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly Lys 
    450         


<210> 100
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 100
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


