                               SEQUENCE LISTING

<110> UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
      HIGHER EDUCATION
 
<120> ONCOLYTIC VIRUSES TARGETING STAT3

<130> 072396.0680

<140> PCT/US2017/042910
<141> 2017-07-19

<150> 62/364,095
<151> 2016-07-19

<160> 43    

<170> PatentIn version 3.5

<210> 1
<211> 628
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro 
            420                 425                 430         


Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro Pro Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Ile 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210> 2
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2
Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro Thr Thr Leu Ala 
1               5                   10                  15      


Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe Thr Phe Ala Leu 
            20                  25                  30          


Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg Glu Val Leu Pro 
        35                  40                  45              


Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu Arg Phe Cys Leu 
    50                  55                  60                  


Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro Pro Asn Leu Phe 
65                  70                  75                  80  


Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly Tyr Leu Pro Pro 
                85                  90                  95      


Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile 
            100                 105                 110         


Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn Thr Ile Val Val 
        115                 120                 125             


Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu Ser Val Tyr Leu 
    130                 135                 140                 


Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys Leu Arg Ala Lys 
145                 150                 155                 160 


Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu 
                165                 170                 175     


Thr Ala Asp Pro Asp Ser Glu Val 
            180                 


<210> 3
<211> 46
<212> PRT
<213> Homo sapiens

<400> 3
Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro Thr Thr Leu 
1               5                   10                  15      


Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe Thr Phe Ala 
            20                  25                  30          


Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg Glu 
        35                  40                  45      


<210> 4
<211> 51
<212> PRT
<213> Homo sapiens

<400> 4
Asp Val Thr Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu 
1               5                   10                  15      


Ile Arg Pro Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu 
            20                  25                  30          


Ala His Phe Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu 
        35                  40                  45              


Thr Ser Arg 
    50      


<210> 5
<211> 188
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
1               5                   10                  15      


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
            20                  25                  30          


Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg 
        35                  40                  45              


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
    50                  55                  60                  


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
65                  70                  75                  80  


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
                85                  90                  95      


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
            100                 105                 110         


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
        115                 120                 125             


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
    130                 135                 140                 


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
145                 150                 155                 160 


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
                165                 170                 175     


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val 
            180                 185             


<210> 6
<211> 628
<212> PRT
<213> Mus musculus

<400> 6
Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Thr Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Leu Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Asn Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Ala 
            420                 425                 430         


Val Gln Glu Gly Ile Gln Pro Glu Ser Lys Lys Arg Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Pro Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Ala Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Ser Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Thr Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Arg Ser Ser Thr Pro Ala Pro Pro Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Ser Ser Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Val 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210> 7
<211> 628
<212> PRT
<213> Rattus norvegicus

<400> 7
Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Ser Pro Leu Ala Ser Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Thr Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Leu Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Asn Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro 
            420                 425                 430         


Val Gln Glu Gly Asn Gln Ser Glu Asn Lys Lys Arg Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Pro Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Ala Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Ser Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Ser Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Thr Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Phe Arg Gly Thr Pro Pro His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Arg Ser Ala Thr Pro Ala Pro Ala Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Ser Ser Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Val 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210> 8
<211> 1887
<212> DNA
<213> Homo sapiens

<400> 8
atggcggagc tgggcgaatt aaagcacatg gtgatgagtt tccgggtgtc tgagctccag       60

gtgcttcttg gctttgctgg ccggaacaag agtggacgga agcacgagct cctggccaag      120

gctctgcacc tcctgaagtc cagctgtgcc cctagtgtcc agatgaagat caaagagctt      180

taccgacgac gctttccccg gaagaccctg gggccctctg atctctccct tctctctttg      240

ccccctggca cctctcctgt aggctcccct ggtcctctag ctcccattcc cccaacgctg      300

ttggcccctg gcaccctgct gggccccaag cgtgaggtgg acatgcaccc ccctctgccc      360

cagcctgtgc accctgatgt caccatgaaa ccattgccct tctatgaagt ctatggggag      420

ctcatccggc ccaccaccct tgcatccact tctagccagc ggtttgagga agcgcacttt      480

acctttgccc tcacacccca gcaagtgcag cagattctta catccagaga ggttctgcca      540

ggagccaaat gtgattatac catacaggtg cagctaaggt tctgtctctg tgagaccagc      600

tgcccccagg aagattattt tccccccaac ctctttgtca aggtcaatgg gaaactgtgc      660

cccctgccgg gttaccttcc cccaaccaag aatggggccg agcccaagag gcccagccgc      720

cccatcaaca tcacacccct ggctcgactc tcagccactg ttcccaacac cattgtggtc      780

aattggtcat ctgagttcgg acggaattac tccttgtctg tgtacctggt gaggcagttg      840

actgcaggaa cccttctaca aaaactcaga gcaaagggta tccggaaccc agaccactcg      900

cgggcactga tcaaggagaa attgactgct gaccctgaca gtgaggtggc cactacaagt      960

ctccgggtgt cactcatgtg cccgctaggg aagatgcgcc tgactgtccc ttgtcgtgcc     1020

ctcacctgcg cccacctgca gagcttcgat gctgcccttt atctacagat gaatgagaag     1080

aagcctacat ggacatgtcc tgtgtgtgac aagaaggctc cctatgaatc tcttatcatt     1140

gatggtttat ttatggagat tcttagttcc tgttcagatt gtgatgagat ccaattcatg     1200

gaagatggat cctggtgccc aatgaaaccc aagaaggagg catctgaggt ttgccccccg     1260

ccagggtatg ggctggatgg cctccagtac agcccagtcc aggggggaga tccatcagag     1320

aataagaaga aggtcgaagt tattgacttg acaatagaaa gctcatcaga tgaggaggat     1380

ctgcccccta ccaagaagca ctgttctgtc acctcagctg ccatcccggc cctacctgga     1440

agcaaaggag tcctgacatc tggccaccag ccatcctcgg tgctaaggag ccctgctatg     1500

ggcacgttgg gtggggattt cctgtccagt ctcccactac atgagtaccc acctgccttc     1560

ccactgggag ccgacatcca aggtttagat ttattttcat ttcttcagac agagagtcag     1620

cactatggcc cctctgtcat cacctcacta gatgaacagg atgcccttgg ccacttcttc     1680

cagtaccgag ggaccccttc tcactttctg ggcccactgg cccccacgct ggggagctcc     1740

cactgcagcg ccactccggc gccccctcct ggccgtgtca gcagcattgt ggcccctggg     1800

ggggccttga gggaggggca tggaggaccc ctgccctcag gtccctcttt gactggctgt     1860

cggtcagaca tcatttccct ggactga                                         1887


<210> 9
<211> 552
<212> DNA
<213> Homo sapiens

<400> 9
cccttctatg aagtctatgg ggagctcatc cggcccacca cccttgcatc cacttctagc       60

cagcggtttg aggaagcgca ctttaccttt gccctcacac cccagcaagt gcagcagatt      120

cttacatcca gagaggttct gccaggagcc aaatgtgatt ataccataca ggtgcagcta      180

aggttctgtc tctgtgagac cagctgcccc caggaagatt attttccccc caacctcttt      240

gtcaaggtca atgggaaact gtgccccctg ccgggttacc ttcccccaac caagaatggg      300

gccgagccca agaggcccag ccgccccatc aacatcacac ccctggctcg actctcagcc      360

actgttccca acaccattgt ggtcaattgg tcatctgagt tcggacggaa ttactccttg      420

tctgtgtacc tggtgaggca gttgactgca ggaacccttc tacaaaaact cagagcaaag      480

ggtatccgga acccagacca ctcgcgggca ctgatcaagg agaaattgac tgctgaccct      540

gacagtgagg tg                                                          552


<210> 10
<211> 138
<212> DNA
<213> Homo sapiens

<400> 10
ttgcccttct atgaagtcta tggggagctc atccggccca ccacccttgc atccacttct       60

agccagcggt ttgaggaagc gcactttacc tttgccctca caccccagca agtgcagcag      120

attcttacat ccagagag                                                    138


<210> 11
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1

<400> 11
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210> 12
<211> 33
<212> DNA
<213> Human immunodeficiency virus 1

<400> 12
tatggcagga agaagcggag acagcgacga aga                                    33


<210> 13
<211> 33
<212> DNA
<213> Human immunodeficiency virus 1

<400> 13
tatggacgaa aaaaacgacg acaacgacga cga                                    33


<210> 14
<211> 24
<212> DNA
<213> Human immunodeficiency virus 1

<400> 14
cgacaacgac gaaagaagcg aggt                                              24


<210> 15
<211> 8
<212> PRT
<213> Human immunodeficiency virus 1

<400> 15
Arg Gln Arg Arg Lys Lys Arg Gly 
1               5               


<210> 16
<211> 40
<212> PRT
<213> Yersinia pestis

<400> 16
Lys Ser Lys Thr Glu Tyr Tyr Asn Ala Trp Ser Glu Trp Glu Arg Asn 
1               5                   10                  15      


Ala Pro Pro Gly Asn Gly Glu Gln Arg Glu Met Ala Val Ser Arg Leu 
            20                  25                  30          


Arg Asp Cys Leu Asp Arg Gln Ala 
        35                  40  


<210> 17
<211> 120
<212> DNA
<213> Yersinia pestis

<400> 17
aagagtaaga cggagtatta caatgcttgg tcagagtggg agcgaaacgc ccctccaggc       60

aatggggagc agcgagagat ggcggtgagt cggttgaggg actgtctcga caggcaggca      120


<210> 18
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Transportan sequence

<400> 18
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 19
<211> 81
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Transportan sequence

<400> 19
ggctggacac ttaacagcgc aggatatttg cttggcaaaa tcaatttgaa ggccttggct       60

gcgcttgcaa aaaaaattct c                                                 81


<210> 20
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Penetratin sequence

<400> 20
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 21
<211> 48
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Penetratin sequence

<400> 21
cggcagataa aaatctggtt ccagaatcgg cgcatgaaat ggaagaaa                    48


<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Arg Arg Arg Arg Arg Arg Arg Arg Arg His His His His His His 
1               5                   10                  15  


<210> 23
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
aggcggcgaa gacgccgcag gagacggcac caccatcacc atcac                       45


<210> 24
<211> 124
<212> PRT
<213> Homo sapiens

<400> 24
Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser 
1               5                   10                  15      


Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser 
            20                  25                  30          


Pro Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val 
        35                  40                  45              


Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro 
65                  70                  75                  80  


Gly Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu 
                85                  90                  95      


Arg Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu 
            100                 105                 110         


Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly 
        115                 120                 


<210> 25
<211> 139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser 
1               5                   10                  15      


Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser 
            20                  25                  30          


Pro Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val 
        35                  40                  45              


Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro 
65                  70                  75                  80  


Gly Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu 
                85                  90                  95      


Arg Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu 
            100                 105                 110         


Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Arg Arg Arg Arg 
        115                 120                 125             


Arg Arg Arg Arg Arg His His His His His His 
    130                 135                 


<210> 26
<211> 124
<212> PRT
<213> Mus musculus

<400> 26
Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser 
1               5                   10                  15      


Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser 
            20                  25                  30          


Ala Val Gln Glu Gly Ile Gln Pro Glu Ser Lys Lys Arg Val Glu Val 
        35                  40                  45              


Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Lys Lys His Cys Pro Val Thr Ser Ala Ala Ile Pro Ala Leu Pro 
65                  70                  75                  80  


Gly Ser Lys Gly Ala Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu 
                85                  90                  95      


Arg Ser Pro Ala Met Gly Thr Leu Gly Ser Asp Phe Leu Ser Ser Leu 
            100                 105                 110         


Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly 
        115                 120                 


<210> 27
<211> 139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser 
1               5                   10                  15      


Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser 
            20                  25                  30          


Ala Val Gln Glu Gly Ile Gln Pro Glu Ser Lys Lys Arg Val Glu Val 
        35                  40                  45              


Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Lys Lys His Cys Pro Val Thr Ser Ala Ala Ile Pro Ala Leu Pro 
65                  70                  75                  80  


Gly Ser Lys Gly Ala Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu 
                85                  90                  95      


Arg Ser Pro Ala Met Gly Thr Leu Gly Ser Asp Phe Leu Ser Ser Leu 
            100                 105                 110         


Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Arg Arg Arg Arg 
        115                 120                 125             


Arg Arg Arg Arg Arg His His His His His His 
    130                 135                 


<210> 28
<211> 225
<212> PRT
<213> Homo sapiens

<400> 28
Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210> 29
<211> 675
<212> DNA
<213> Homo sapiens

<400> 29
atggtcaccc acagcaagtt tcccgccgcc gggatgagcc gccccctgga caccagcctg       60

cgcctcaaga ccttcagctc caagagcgag taccagctgg tggtgaacgc agtgcgcaag      120

ctgcaggaga gcggcttcta ctggagcgca gtgaccggcg gcgaggcgaa cctgctgctc      180

agtgccgagc ccgccggcac ctttctgatc cgcgacagct cggaccagcg ccacttcttc      240

acgctcagcg tcaagaccca gtctgggacc aagaacctgc gcatccagtg tgaggggggc      300

agcttctctc tgcagagcga tccccggagc acgcagcccg tgccccgctt cgactgcgtg      360

ctcaagctgg tgcaccacta catgccgccc cctggagccc cctccttccc ctcgccacct      420

actgaaccct cctccgaggt gcccgagcag ccgtctgccc agccactccc tgggagtccc      480

cccagaagag cctattacat ctactccggg ggcgagaaga tccccctggt gttgagccgg      540

cccctctcct ccaacgtggc cactcttcag catctctgtc ggaagaccgt caacggccac      600

ctggactcct atgagaaagt cacccagctg ccggggccca ttcgggagtt cctggaccag      660

tacgatgccc cgctt                                                       675


<210> 30
<211> 225
<212> PRT
<213> Mus musculus

<400> 30
Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Thr Pro Ser Phe Ser Leu Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Pro Ala Gln Ala Leu Pro Gly Ser Thr 
145                 150                 155                 160 


Pro Lys Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210> 31
<211> 678
<212> DNA
<213> Mus musculus

<400> 31
atggtcaccc acagcaagtt tcccgccgcc gggatgagcc gccccctgga caccagcctg       60

cgcctcaaga ccttcagctc caaaagcgag taccagctgg tggtgaacgc cgtgcgcaag      120

ctgcaggaga gcggattcta ctggagcgcc gtgaccggcg gcgaggcgaa cctgctgctc      180

agcgccgagc ccgcgggcac ctttcttatc cgcgacagct cggaccagcg ccacttcttc      240

acgttgagcg tcaagaccca gtcggggacc aagaacctac gcatccagtg tgaggggggc      300

agcttttcgc tgcagagtga cccccgaagc acgcagccag ttccccgctt cgactgtgta      360

ctcaagctgg tgcaccacta catgccgcct ccagggaccc cctccttttc tttgccaccc      420

acggaaccct cgtccgaagt tccggagcag ccacctgccc aggcactccc cgggagtacc      480

cccaagagag cttactacat ctattctggg ggcgagaaga ttccgctggt actgagccga      540

cctctctcct ccaacgtggc caccctccag catctttgtc ggaagactgt caacggccac      600

ctggactcct atgagaaagt gacccagctg cctggaccca ttcgggagtt cctggatcag      660

tatgatgctc cactttaa                                                    678


<210> 32
<211> 387
<212> PRT
<213> Homo sapiens

<400> 32
Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg 
            340                 345                 350         


Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met 
        355                 360                 365             


Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Pro Arg Leu 
    370                 375                 380                 


Thr Asp Thr 
385         


<210> 33
<211> 1721
<212> DNA
<213> Homo sapiens

<400> 33
gctcgggcgc cgagtctgcg cgctgacgtc cgacgctcca ggtactttcc ccacggccga       60

cagggcttgg cgtgggggcg gggcgcggcg cgcagcgcgc atgcgccgca gcgccagcgc      120

tctccccgga tcgtgcgggg cctgagcctc tccgccggcg caggctctgc tcgcgccagc      180

tcgctcccgc agccatgccc accaccatcg agcgggagtt cgaagagttg gatactcagc      240

gtcgctggca gccgctgtac ttggaaattc gaaatgagtc ccatgactat cctcatagag      300

tggccaagtt tccagaaaac agaaatcgaa acagatacag agatgtaagc ccatatgatc      360

acagtcgtgt taaactgcaa aatgctgaga atgattatat taatgccagt ttagttgaca      420

tagaagaggc acaaaggagt tacatcttaa cacagggtcc acttcctaac acatgctgcc      480

atttctggct tatggtttgg cagcagaaga ccaaagcagt tgtcatgctg aaccgcattg      540

tggagaaaga atcggttaaa tgtgcacagt actggccaac agatgaccaa gagatgctgt      600

ttaaagaaac aggattcagt gtgaagctct tgtcagaaga tgtgaagtcg tattatacag      660

tacatctact acaattagaa aatatcaata gtggtgaaac cagaacaata tctcactttc      720

attatactac ctggccagat tttggagtcc ctgaatcacc agcttcattt ctcaatttct      780

tgtttaaagt gagagaatct ggctccttga accctgacca tgggcctgcg gtgatccact      840

gtagtgcagg cattgggcgc tctggcacct tctctctggt agacacttgt cttgttttga      900

tggaaaaagg agatgatatt aacataaaac aagtgttact gaacatgaga aaataccgaa      960

tgggtcttat tcagacccca gatcaactga gattctcata catggctata atagaaggag     1020

caaaatgtat aaagggagat tctagtatac agaaacgatg gaaagaactt tctaaggaag     1080

acttatctcc tgcctttgat cattcaccaa acaaaataat gactgaaaaa tacaatggga     1140

acagaatagg tctagaagaa gaaaaactga caggtgaccg atgtacagga ctttcctcta     1200

aaatgcaaga tacaatggag gagaacagtg agagtgctct acggaaacgt attcgagagg     1260

acagaaaggc caccacagct cagaaggtgc agcagatgaa acagaggcta aatgagaatg     1320

aacgaaaaag aaaaaggcca agattgacag acacctaata ttcatgactt gagaatattc     1380

tgcagctata aattttgaac cattgatgtg caaagcaaga cctgaagccc actccggaaa     1440

ctaaagtgag gctcgctaac cctctagatt gcctcacagt tgtttgttta caaagtaaac     1500

tttacatcca ggggatgaag agcacccacc agcagaagac tttgcagaac ctttaattgg     1560

atgtgttaag tgtttttaat gagtgtatga aatgtagaaa gatgtacaag aaataaatta     1620

ggggagatta ctttgtattg tactgccatt cctactgtat ttttatactt tttggcagca     1680

ttaaatattt ttgttaaata gtcaaaaaaa aaaaaaaaaa a                         1721


<210> 34
<211> 382
<212> PRT
<213> Mus musculus

<400> 34
Met Ser Ala Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Ala Gln Cys 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Ser Thr 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Thr Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Arg Glu Met Val Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Thr Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Cys Leu Thr Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Glu 
225                 230                 235                 240 


Asp Val Asn Val Lys Gln Leu Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Tyr Thr Lys Gly Asp Ser Asn Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ile Cys Asp His Ser 
    290                 295                 300                 


Gln Asn Arg Val Met Val Glu Lys Tyr Asn Gly Lys Arg Ile Gly Ser 
305                 310                 315                 320 


Glu Asp Glu Lys Leu Thr Gly Leu Pro Ser Lys Val Gln Asp Thr Val 
                325                 330                 335     


Glu Glu Ser Ser Glu Ser Ile Leu Arg Lys Arg Ile Arg Glu Asp Arg 
            340                 345                 350         


Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met Lys Gln Arg Leu Asn 
        355                 360                 365             


Glu Thr Glu Arg Lys Arg Lys Arg Pro Arg Leu Thr Asp Thr 
    370                 375                 380         


<210> 35
<211> 1149
<212> DNA
<213> Mus musculus

<400> 35
atgagcgcca ctattgagcg ggagttcgag gaactggacg cccagtgtag atggcagccc       60

ctttatcttg agatacgcaa cgaaagtcac gattaccctc atagggtagc taaattccct      120

gagaacagaa acagaaaccg ctaccgcgat gtgtcaccct acgatcactc cagagtgaaa      180

cttcaaagta ccgaaaatga ttatataaat gccagcttgg tggacataga ggaagcccaa      240

agatcataca tacttactca agggcctctc ccaaacactt gttgccattt ctggctcatg      300

gtgtggcaac agaagaccaa ggctgtggta atgctcaatc ggactgtgga aaaagagtca      360

gtaaagtgtg ctcaatattg gccaactgat gatagggaga tggtctttaa ggaaacaggt      420

ttctccgtta agttgctcag tgaggatgtg aagtcctatt acacagtaca tcttctccaa      480

ttggagaaca tcaacaccgg tgaaacccga acaatatccc actttcatta taccacttgg      540

cctgacttcg gtgttcctga aagccccgct tcttttctca atttcctgtt taaggtgcgg      600

gagtcaggct gtctcacccc agatcatggg cctgctgtaa tacattgtag cgctgggatc      660

gggcgatccg ggacattctc tttggtagac acttgcctgg tcctgatgga gaagggagag      720

gacgtaaacg ttaagcagtt gctcctgaat atgagaaaat atcgaatggg gttgattcag      780

actcccgatc aacttagatt ctcttatatg gctataatcg agggcgcaaa atataccaag      840

ggggactcca acattcaaaa aagatggaag gagctctcta aggaagatct gtctccaatc      900

tgtgaccaca gtcagaaccg agttatggta gagaaataca acggtaaaag aattggctca      960

gaagacgaaa aactgaccgg actcccctcc aaagtgcaag atacagtcga agaatcatcc     1020

gagtcaatct tgaggaaaag aatcagggaa gatcggaagg ccactacagc ccaaaaagtg     1080

caacaaatga aacagcgact caacgaaaca gagcggaaac gaaaacggcc aagactgaca     1140

gacacctaa                                                             1149


<210> 36
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Phe 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210> 37
<211> 2310
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag       60

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      120

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      180

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      240

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      300

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      360

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      420

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      480

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      540

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      600

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      660

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      720

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta      780

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa      840

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag      900

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc      960

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1020

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1080

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1140

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1200

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1260

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc     1320

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1380

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1440

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1500

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1560

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1620

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1680

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1740

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     1800

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     1860

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     1920

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     1980

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2040

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggc     2100

gctgccccat tcctgaagac caagtttatc tgtgtgacac caacgacctg cagcaatacc     2160

attgacctgc cgatgtcccc ccgcacttta gattcattga tgcagtttgg aaataatggt     2220

gaaggtgctg aaccctcagc aggagggcag tttgagtccc tcacctttga catggagttg     2280

acctcggagt gcgctacctc ccccatgtga                                      2310


<210> 38
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Ala Ala Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210> 39
<211> 2310
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag       60

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      120

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      180

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      240

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      300

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      360

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      420

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      480

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      540

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      600

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      660

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      720

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta      780

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa      840

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag      900

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc      960

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1020

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1080

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1140

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1200

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1260

gggggccgag ccaattgtga tgcttccctg attgtgactg cggcgctgca cctgatcacc     1320

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1380

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1440

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1500

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1560

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1620

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1680

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1740

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     1800

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     1860

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     1920

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     1980

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2040

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggc     2100

gctgccccat acctgaagac caagtttatc tgtgtgacac caacgacctg cagcaatacc     2160

attgacctgc cgatgtcccc ccgcacttta gattcattga tgcagtttgg aaataatggt     2220

gaaggtgctg aaccctcagc aggagggcag tttgagtccc tcacctttga catggagttg     2280

acctcggagt gcgctacctc ccccatgtga                                      2310


<210> 40
<211> 372
<212> DNA
<213> Homo sapiens

<400> 40
atggaagatg gatcctggtg cccaatgaaa cccaagaagg aggcatctga ggtttgcccc       60

ccgccagggt atgggctgga tggcctccag tacagcccag tccagggggg agatccatca      120

gagaataaga agaaggtcga agttattgac ttgacaatag aaagctcatc agatgaggag      180

gatctgcccc ctaccaagaa gcactgttct gtcacctcag ctgccatccc ggccctacct      240

ggaagcaaag gagtcctgac atctggccac cagccatcct cggtgctaag gagccctgct      300

atgggcacgt tgggtgggga tttcctgtcc agtctcccac tacatgagta cccacctgcc      360

ttcccactgg ga                                                          372


<210> 41
<211> 420
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atggaagatg gatcctggtg cccaatgaaa cccaagaagg aggcatctga ggtttgcccc       60

ccgccagggt atgggctgga tggcctccag tacagcccag tccagggggg agatccatca      120

gagaataaga agaaggtcga agttattgac ttgacaatag aaagctcatc agatgaggag      180

gatctgcccc ctaccaagaa gcactgttct gtcacctcag ctgccatccc ggccctacct      240

ggaagcaaag gagtcctgac atctggccac cagccatcct cggtgctaag gagccctgct      300

atgggcacgt tgggtgggga tttcctgtcc agtctcccac tacatgagta cccacctgcc      360

ttcccactgg gaaggcggcg aagacgccgc aggagacggc accaccatca ccatcactaa      420


<210> 42
<211> 378
<212> DNA
<213> Mus musculus

<400> 42
atggaagatg gatcctggtg tccgatgaaa cccaagaagg aggcatcaga ggtttgcccc       60

ccgccagggt atgggctgga tggtctccag tacagcgcag tccaggaggg aattcagcca      120

gagagtaaga agagggtcga agtcattgac ttgaccatcg aaagctcatc agatgaggag      180

gatttgcccc ccaccaagaa gcactgccct gtcacctcag cggccattcc agcccttcct      240

ggaagcaaag gagccctgac ctctggtcac cagccatcct cggtgctgcg gagccctgca      300

atgggcacac tgggcagtga cttcctgtct agtctcccgc tacatgagta cccacctgcc      360

ttcccactgg ggcgacga                                                    378


<210> 43
<211> 420
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
atggaagatg gatcctggtg tccgatgaaa cccaagaagg aggcatcaga ggtttgcccc       60

ccgccagggt atgggctgga tggtctccag tacagcgcag tccaggaggg aattcagcca      120

gagagtaaga agagggtcga agtcattgac ttgaccatcg aaagctcatc agatgaggag      180

gatttgcccc ccaccaagaa gcactgccct gtcacctcag cggccattcc agcccttcct      240

ggaagcaaag gagccctgac ctctggtcac cagccatcct cggtgctgcg gagccctgca      300

atgggcacac tgggcagtga cttcctgtct agtctcccgc tacatgagta cccacctgcc      360

ttcccactgg ggcgacgaag gcggcgaaga cggaggcggc atcaccatca tcaccactaa      420


