                               SEQUENCE LISTING

<110> AERPIO THERAPEUTICS, INC.
 
<120> HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-BETA)

<130> 45725-724.601

<140> PCT/US2017/042855
<141> 2017-07-19

<150> 62/377,072
<151> 2016-08-19

<150> 62/364,381
<151> 2016-07-20

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Asp Phe Gly Leu Ser Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                85                  90                  95      


Gln Asn Met Leu Tyr Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210> 2
<211> 100
<212> PRT
<213> Homo sapiens

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg 
            100 


<210> 3
<211> 100
<212> PRT
<213> Homo sapiens

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Thr Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg 
            100 


<210> 4
<211> 98
<212> PRT
<213> Homo sapiens

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210> 5
<211> 122
<212> PRT
<213> Homo sapiens

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ile Arg Asp Tyr Tyr Gly Ala Thr Arg Gly Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 6
<211> 120
<212> PRT
<213> Homo sapiens

<400> 6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Thr Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Val Val Gly Ala Thr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 7
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Pro Ala Asp Phe Tyr Tyr Tyr Ser Ser Gly Gln 
            100                 105                 110         


Thr Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 8
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Ser Ser Trp Tyr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 9
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 10
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 11
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 12
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val His 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 13
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro 
    50                  55                  60                  


Lys Gln Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210> 14
<211> 95
<212> PRT
<213> Homo sapiens

<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95  


<210> 15
<211> 101
<212> PRT
<213> Homo sapiens

<400> 15
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro 
            100     


<210> 16
<211> 107
<212> PRT
<213> Homo sapiens

<400> 16
Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Leu Gly Gly Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 17
<211> 113
<212> PRT
<213> Homo sapiens

<400> 17
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 18
<211> 107
<212> PRT
<213> Homo sapiens

<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His His Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 19
<211> 113
<212> PRT
<213> Homo sapiens

<400> 19
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Glu Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 20
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 21
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 22
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 23
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 24
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210> 26
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 27
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 28
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                85                  90                  95      


Gln Asn Met Leu Tyr Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210> 29
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Ala Tyr Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210> 30
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210> 31
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210> 32
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ala Asn Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val His Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210> 33
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro 
    50                  55                  60                  


Lys Gln Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 34
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 35
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 36
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 37
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln His 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Glu Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 38
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala Glu Ser Lys 
            20                  25                  30          


Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu Gly Ser Pro 
        35                  40                  45              


Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly Ala Ala Leu 
    50                  55                  60                  


Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys Asn Leu Gln 
65                  70                  75                  80  


Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Lys Ile Ile Ser Leu Asp 
                85                  90                  95      


Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro Pro Ala Arg 
            100                 105                 110         


Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Gly Leu His Val Trp 
        115                 120                 125             


Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val Gln Leu Phe 
    130                 135                 140                 


Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln Glu Ser Thr 
145                 150                 155                 160 


Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly Ser Lys Tyr 
                165                 170                 175     


Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser Phe Ser Val 
            180                 185                 190         


Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp Ile Gly Ile 
        195                 200                 205             


Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His Gly Ser Gly 
    210                 215                 220                 


Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly Ile Leu Val 
225                 230                 235                 240 


His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala Phe His Gly 
                245                 250                 255     


Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr Glu Ala Ala 
            260                 265                 270         


Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala Pro Met Glu 
        275                 280                 285             


Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr Ser Leu Lys 
    290                 295                 300                 


Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr Asn Ile Thr 
305                 310                 315                 320 


Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu Ala Pro Trp 
                325                 330                 335     


Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg Leu Tyr Gln 
            340                 345                 350         


Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln Lys Met Ala 
        355                 360                 365             


Val Gly Arg Thr Phe Pro Leu Ala Val Leu Gln Leu Arg Val Lys His 
    370                 375                 380                 


Ala Asn Glu Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu 
385                 390                 395                 400 


Trp Glu Lys Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile 
                405                 410                 415     


His Lys Ser Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu 
            420                 425                 430         


Val Pro Gly Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp 
        435                 440                 445             


Leu Lys Asn Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val 
    450                 455                 460                 


Thr Asp Leu His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr 
465                 470                 475                 480 


Asn Trp Thr Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu 
                485                 490                 495     


Ile His Glu Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr 
            500                 505                 510         


Ser Arg Tyr Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val 
        515                 520                 525             


Val Val Thr Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val 
    530                 535                 540                 


Glu Gly Arg Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn 
545                 550                 555                 560 


Ser Gly Arg Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly 
                565                 570                 575     


Asp Val Asp Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val 
            580                 585                 590         


Gln Ser Leu Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser 
        595                 600                 605             


Leu Thr Pro Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly 
    610                 615                 620                 


Lys Tyr Glu Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys 
625                 630                 635                 640 


Val Gln Gly Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg 
                645                 650                 655     


Val Ser Trp Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr 
            660                 665                 670         


Ile Lys Asn Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser 
        675                 680                 685             


Glu Asn Glu Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser 
    690                 695                 700                 


Val Thr Val Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly 
705                 710                 715                 720 


Asn Gly Arg Thr Ile Pro Glu Lys Gly Asn Ser Ala Asp Ile Gln His 
                725                 730                 735     


Ser Gly Gly Arg Ser Ser Leu Glu Gly Pro Arg Phe Glu Arg Thr Gly 
            740                 745                 750         


Gly Gly His His His His His His 
        755                 760 


<210> 39
<211> 1997
<212> PRT
<213> Homo sapiens

<400> 39
Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu 
1               5                   10                  15      


Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala 
            20                  25                  30          


Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu 
        35                  40                  45              


Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly 
    50                  55                  60                  


Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile 
                85                  90                  95      


Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro 
            100                 105                 110         


Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu 
        115                 120                 125             


His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val 
    130                 135                 140                 


Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly 
                165                 170                 175     


Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser 
            180                 185                 190         


Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp 
        195                 200                 205             


Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His 
    210                 215                 220                 


Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly 
225                 230                 235                 240 


Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala 
                245                 250                 255     


Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr 
            260                 265                 270         


Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala 
        275                 280                 285             


Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr 
    290                 295                 300                 


Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr 
305                 310                 315                 320 


Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu 
                325                 330                 335     


Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg 
            340                 345                 350         


Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln 
        355                 360                 365             


Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu 
    370                 375                 380                 


Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro 
385                 390                 395                 400 


Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser 
                405                 410                 415     


Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val 
            420                 425                 430         


Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val 
        435                 440                 445             


Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg 
    450                 455                 460                 


Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu 
465                 470                 475                 480 


Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys 
                485                 490                 495     


Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser 
            500                 505                 510         


Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly 
        515                 520                 525             


Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn 
    530                 535                 540                 


Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu 
545                 550                 555                 560 


His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr 
                565                 570                 575     


Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu 
            580                 585                 590         


Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr 
        595                 600                 605             


Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr 
    610                 615                 620                 


Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg 
625                 630                 635                 640 


Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg 
                645                 650                 655     


Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp 
            660                 665                 670         


Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu 
        675                 680                 685             


Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro 
    690                 695                 700                 


Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu 
705                 710                 715                 720 


Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly 
                725                 730                 735     


Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp 
            740                 745                 750         


Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn 
        755                 760                 765             


Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu 
    770                 775                 780                 


Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val 
785                 790                 795                 800 


Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg 
                805                 810                 815     


Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr 
            820                 825                 830         


Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln 
        835                 840                 845             


Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe 
    850                 855                 860                 


His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro 
865                 870                 875                 880 


Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln 
                885                 890                 895     


Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn 
            900                 905                 910         


Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp 
        915                 920                 925             


Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg 
    930                 935                 940                 


His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu 
945                 950                 955                 960 


His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile 
                965                 970                 975     


Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg 
            980                 985                 990         


Thr Val Pro Ala Ser Val Gln Gly  Val Ile Ala Asp Asn  Ala Tyr Ser 
        995                 1000                 1005             


Ser Tyr  Ser Leu Ile Val Ser  Trp Gln Lys Ala Ala  Gly Val Ala 
    1010                 1015                 1020             


Glu Arg  Tyr Asp Ile Leu Leu  Leu Thr Glu Asn Gly  Ile Leu Leu 
    1025                 1030                 1035             


Arg Asn  Thr Ser Glu Pro Ala  Thr Thr Lys Gln His  Lys Phe Glu 
    1040                 1045                 1050             


Asp Leu  Thr Pro Gly Lys Lys  Tyr Lys Ile Gln Ile  Leu Thr Val 
    1055                 1060                 1065             


Ser Gly  Gly Leu Phe Ser Lys  Glu Ala Gln Thr Glu  Gly Arg Thr 
    1070                 1075                 1080             


Val Pro  Ala Ala Val Thr Asp  Leu Arg Ile Thr Glu  Asn Ser Thr 
    1085                 1090                 1095             


Arg His  Leu Ser Phe Arg Trp  Thr Ala Ser Glu Gly  Glu Leu Ser 
    1100                 1105                 1110             


Trp Tyr  Asn Ile Phe Leu Tyr  Asn Pro Asp Gly Asn  Leu Gln Glu 
    1115                 1120                 1125             


Arg Ala  Gln Val Asp Pro Leu  Val Gln Ser Phe Ser  Phe Gln Asn 
    1130                 1135                 1140             


Leu Leu  Gln Gly Arg Met Tyr  Lys Met Val Ile Val  Thr His Ser 
    1145                 1150                 1155             


Gly Glu  Leu Ser Asn Glu Ser  Phe Ile Phe Gly Arg  Thr Val Pro 
    1160                 1165                 1170             


Ala Ser  Val Ser His Leu Arg  Gly Ser Asn Arg Asn  Thr Thr Asp 
    1175                 1180                 1185             


Ser Leu  Trp Phe Asn Trp Ser  Pro Ala Ser Gly Asp  Phe Asp Phe 
    1190                 1195                 1200             


Tyr Glu  Leu Ile Leu Tyr Asn  Pro Asn Gly Thr Lys  Lys Glu Asn 
    1205                 1210                 1215             


Trp Lys  Asp Lys Asp Leu Thr  Glu Trp Arg Phe Gln  Gly Leu Val 
    1220                 1225                 1230             


Pro Gly  Arg Lys Tyr Val Leu  Trp Val Val Thr His  Ser Gly Asp 
    1235                 1240                 1245             


Leu Ser  Asn Lys Val Thr Ala  Glu Ser Arg Thr Ala  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Leu Met Ser Phe Ala  Asp Ile Ala Asn Thr  Ser Leu Ala 
    1265                 1270                 1275             


Ile Thr  Trp Lys Gly Pro Pro  Asp Trp Thr Asp Tyr  Asn Asp Phe 
    1280                 1285                 1290             


Glu Leu  Gln Trp Leu Pro Arg  Asp Ala Leu Thr Val  Phe Asn Pro 
    1295                 1300                 1305             


Tyr Asn  Asn Arg Lys Ser Glu  Gly Arg Ile Val Tyr  Gly Leu Arg 
    1310                 1315                 1320             


Pro Gly  Arg Ser Tyr Gln Phe  Asn Val Lys Thr Val  Ser Gly Asp 
    1325                 1330                 1335             


Ser Trp  Lys Thr Tyr Ser Lys  Pro Ile Phe Gly Ser  Val Arg Thr 
    1340                 1345                 1350             


Lys Pro  Asp Lys Ile Gln Asn  Leu His Cys Arg Pro  Gln Asn Ser 
    1355                 1360                 1365             


Thr Ala  Ile Ala Cys Ser Trp  Ile Pro Pro Asp Ser  Asp Phe Asp 
    1370                 1375                 1380             


Gly Tyr  Ser Ile Glu Cys Arg  Lys Met Asp Thr Gln  Glu Val Glu 
    1385                 1390                 1395             


Phe Ser  Arg Lys Leu Glu Lys  Glu Lys Ser Leu Leu  Asn Ile Met 
    1400                 1405                 1410             


Met Leu  Val Pro His Lys Arg  Tyr Leu Val Ser Ile  Lys Val Gln 
    1415                 1420                 1425             


Ser Ala  Gly Met Thr Ser Glu  Val Val Glu Asp Ser  Thr Ile Thr 
    1430                 1435                 1440             


Met Ile  Asp Arg Pro Pro Pro  Pro Pro Pro His Ile  Arg Val Asn 
    1445                 1450                 1455             


Glu Lys  Asp Val Leu Ile Ser  Lys Ser Ser Ile Asn  Phe Thr Val 
    1460                 1465                 1470             


Asn Cys  Ser Trp Phe Ser Asp  Thr Asn Gly Ala Val  Lys Tyr Phe 
    1475                 1480                 1485             


Thr Val  Val Val Arg Glu Ala  Asp Gly Ser Asp Glu  Leu Lys Pro 
    1490                 1495                 1500             


Glu Gln  Gln His Pro Leu Pro  Ser Tyr Leu Glu Tyr  Arg His Asn 
    1505                 1510                 1515             


Ala Ser  Ile Arg Val Tyr Gln  Thr Asn Tyr Phe Ala  Ser Lys Cys 
    1520                 1525                 1530             


Ala Glu  Asn Pro Asn Ser Asn  Ser Lys Ser Phe Asn  Ile Lys Leu 
    1535                 1540                 1545             


Gly Ala  Glu Met Glu Ser Leu  Gly Gly Lys Cys Asp  Pro Thr Gln 
    1550                 1555                 1560             


Gln Lys  Phe Cys Asp Gly Pro  Leu Lys Pro His Thr  Ala Tyr Arg 
    1565                 1570                 1575             


Ile Ser  Ile Arg Ala Phe Thr  Gln Leu Phe Asp Glu  Asp Leu Lys 
    1580                 1585                 1590             


Glu Phe  Thr Lys Pro Leu Tyr  Ser Asp Thr Phe Phe  Ser Leu Pro 
    1595                 1600                 1605             


Ile Thr  Thr Glu Ser Glu Pro  Leu Phe Gly Ala Ile  Glu Gly Val 
    1610                 1615                 1620             


Ser Ala  Gly Leu Phe Leu Ile  Gly Met Leu Val Ala  Val Val Ala 
    1625                 1630                 1635             


Leu Leu  Ile Cys Arg Gln Lys  Val Ser His Gly Arg  Glu Arg Pro 
    1640                 1645                 1650             


Ser Ala  Arg Leu Ser Ile Arg  Arg Asp Arg Pro Leu  Ser Val His 
    1655                 1660                 1665             


Leu Asn  Leu Gly Gln Lys Gly  Asn Arg Lys Thr Ser  Cys Pro Ile 
    1670                 1675                 1680             


Lys Ile  Asn Gln Phe Glu Gly  His Phe Met Lys Leu  Gln Ala Asp 
    1685                 1690                 1695             


Ser Asn  Tyr Leu Leu Ser Lys  Glu Tyr Glu Glu Leu  Lys Asp Val 
    1700                 1705                 1710             


Gly Arg  Asn Gln Ser Cys Asp  Ile Ala Leu Leu Pro  Glu Asn Arg 
    1715                 1720                 1725             


Gly Lys  Asn Arg Tyr Asn Asn  Ile Leu Pro Tyr Asp  Ala Thr Arg 
    1730                 1735                 1740             


Val Lys  Leu Ser Asn Val Asp  Asp Asp Pro Cys Ser  Asp Tyr Ile 
    1745                 1750                 1755             


Asn Ala  Ser Tyr Ile Pro Gly  Asn Asn Phe Arg Arg  Glu Tyr Ile 
    1760                 1765                 1770             


Val Thr  Gln Gly Pro Leu Pro  Gly Thr Lys Asp Asp  Phe Trp Lys 
    1775                 1780                 1785             


Met Val  Trp Glu Gln Asn Val  His Asn Ile Val Met  Val Thr Gln 
    1790                 1795                 1800             


Cys Val  Glu Lys Gly Arg Val  Lys Cys Asp His Tyr  Trp Pro Ala 
    1805                 1810                 1815             


Asp Gln  Asp Ser Leu Tyr Tyr  Gly Asp Leu Ile Leu  Gln Met Leu 
    1820                 1825                 1830             


Ser Glu  Ser Val Leu Pro Glu  Trp Thr Ile Arg Glu  Phe Lys Ile 
    1835                 1840                 1845             


Cys Gly  Glu Glu Gln Leu Asp  Ala His Arg Leu Ile  Arg His Phe 
    1850                 1855                 1860             


His Tyr  Thr Val Trp Pro Asp  His Gly Val Pro Glu  Thr Thr Gln 
    1865                 1870                 1875             


Ser Leu  Ile Gln Phe Val Arg  Thr Val Arg Asp Tyr  Ile Asn Arg 
    1880                 1885                 1890             


Ser Pro  Gly Ala Gly Pro Thr  Val Val His Cys Ser  Ala Gly Val 
    1895                 1900                 1905             


Gly Arg  Thr Gly Thr Phe Ile  Ala Leu Asp Arg Ile  Leu Gln Gln 
    1910                 1915                 1920             


Leu Asp  Ser Lys Asp Ser Val  Asp Ile Tyr Gly Ala  Val His Asp 
    1925                 1930                 1935             


Leu Arg  Leu His Arg Val His  Met Val Gln Thr Glu  Cys Gln Tyr 
    1940                 1945                 1950             


Val Tyr  Leu His Gln Cys Val  Arg Asp Val Leu Arg  Ala Arg Lys 
    1955                 1960                 1965             


Leu Arg  Ser Glu Gln Glu Asn  Pro Leu Phe Pro Ile  Tyr Glu Asn 
    1970                 1975                 1980             


Val Asn  Pro Glu Tyr His Arg  Asp Pro Val Tyr Ser  Arg His 
    1985                 1990                 1995         


<210> 40
<211> 2283
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgag       60

cccgagagat gcaacttcac cctggccgag tccaaggcct cctcccactc cgtgtctatc      120

cagtggcgga tcctgggctc cccctgcaac ttctctctga tctactcctc cgacaccctg      180

ggcgctgccc tgtgccctac cttcagaatc gacaacacca cctacggctg caacctgcag      240

gatctgcagg ccggcaccat ctacaacttc aagatcatct ccctggacga ggaacggacc      300

gtggtgctgc agaccgatcc tctgcctcct gccagattcg gcgtgtccaa agaaaagacc      360

acctccaccg gactgcacgt gtggtggacc ccttccagcg gcaaagtgac ctcctacgag      420

gtgcagctgt tcgacgagaa caaccagaaa atccagggcg tgcagatcca ggaatccacc      480

tcctggaacg agtacacctt cttcaacctg accgccggct ccaagtacaa tatcgccatc      540

accgccgtgt ccggcggcaa gagatccttc tccgtgtaca ccaacggctc caccgtgccc      600

agccccgtga aggacatcgg catctccacc aaggccaact ccctgctgat ctcctggtcc      660

cacggctccg gcaacgtgga acggtacaga ctgatgctga tggacaaggg catcctggtg      720

cacggcggcg tggtggataa gcacgccacc tcttacgcct tccacggcct gacccctggc      780

tacctgtaca atctgaccgt gatgaccgag gccgctggac tgcagaacta ccggtggaag      840

ctcgtgcgga ccgcccccat ggaagtgtcc aacctgaaag tgaccaacga cggctccctg      900

acctctctga aagtgaagtg gcagaggccc cctggcaatg tggactccta caacatcacc      960

ctgtcccaca agggcaccat caaagaatcc cgggtgctgg ccccttggat caccgagaca     1020

cacttcaaag aactggtgcc tggccggctg taccaagtga ccgtgtcctg tgtgtctggc     1080

gagctgtccg cccagaaaat ggccgtgggc agaaccttcc ctctggccgt gctgcagctg     1140

agagtgaagc acgctaacga gacatccctg tccatcatgt ggcagacccc cgtggccgag     1200

tgggagaagt acatcatcag cctggccgac cgggacctgc tgctgatcca caagtccctg     1260

agcaaggacg ccaaagagtt caccttcacc gacctggtgc ccggcagaaa gtacatggcc     1320

accgtgacct ccatctccgg cgacctgaag aactcctcca gcgtgaaggg caggaccgtg     1380

cctgcccaag tgacagacct gcacgtggcc aaccagggca tgacctcctc cctgttcacc     1440

aactggaccc aggctcaggg cgacgtggaa ttctaccagg tgctgctgat tcatgagaac     1500

gtcgtgatca agaacgagtc catctcctcc gagacaagcc ggtactcctt ccactccctg     1560

aagtccggca gcctgtactc cgtggtcgtg accacagtgt ccgggggcat ctcctctaga     1620

caggtggtgg tggaaggccg caccgtgcct agttcagtgt caggcgtgac cgtgaacaac     1680

agcggccgga acgactacct gtccgtgtct tggctgctgg ctcctgggga cgtggacaac     1740

tacgaagtga ccctgagcca cgacggcaag gtggtgcagt ctctcgtgat cgccaagtcc     1800

gtgcgcgagt gctccttcag ctctctgaca cctggcagac tgtataccgt gaccatcacc     1860

accagatccg ggaagtacga gaaccacagc ttctcccagg aacgcacagt gcccgacaag     1920

gtgcagggcg tgtcagtgtc taactccgcc agatctgact acctgcgggt gtcctgggtg     1980

cacgctaccg gcgacttcga ccattatgaa gtgacaatca agaacaagaa caacttcatc     2040

cagaccaagt ccatccccaa gtccgagaac gagtgcgtgt tcgtgcagct ggtgccaggc     2100

agactgtact ctgtgacagt gaccaccaag tccggccagt acgaggccaa cgagcagggc     2160

aacggcagga ccatccctga gaagggcaac tccgccgaca tccagcactc tggcggcaga     2220

tcctctctgg aaggccccag attcgagaga accggcggag gccaccacca tcatcaccat     2280

tga                                                                   2283


<210> 41
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Arg Cys Asn Phe Thr Leu Ala Glu Ser Lys Ala Ser 
            20                  25                  30          


Ser His Ser Val Ser Ile Arg Trp Arg Ile Trp Gly Ser Pro Cys Asn 
        35                  40                  45              


Phe Asn Leu Thr Tyr Ser Ser Asp Thr Leu Gly Ala Ala Ser Cys Pro 
    50                  55                  60                  


Pro Phe Arg Leu Asp Asn Thr Thr Tyr Gly Cys Asn Leu Gln Asp Leu 
65                  70                  75                  80  


Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Val Ser Leu Asp Gly Glu 
                85                  90                  95      


Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro Pro Ala Arg Phe 
            100                 105                 110         


Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu His Val Trp Trp 
        115                 120                 125             


Thr Pro Ser Pro Gly Lys Val Thr Ser Tyr Glu Val Gln Leu Phe Asp 
    130                 135                 140                 


Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln Glu Ser Thr Ser 
145                 150                 155                 160 


Trp Asn Lys Tyr Thr Phe Phe Asn Leu Thr Ala Gly Ser Lys Tyr Asn 
                165                 170                 175     


Ile Thr Ile Thr Ala Val Ser Gly Gly Lys Arg Ser Ser Ser Val Tyr 
            180                 185                 190         


Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp Ile Gly Ile Ser 
        195                 200                 205             


Thr Lys Ala Asn Ser Leu Leu Val Ser Trp Ser His Gly Ser Gly Asn 
    210                 215                 220                 


Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly Ile Leu Val His 
225                 230                 235                 240 


Gly Ser Val Val Asp Arg Gln Ala Thr Ser Tyr Thr Phe Asn Gly Leu 
                245                 250                 255     


Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Val Thr Glu Ala Ala Gly 
            260                 265                 270         


Leu Gln Asn Tyr Lys Trp Lys Leu Val Arg Thr Ala Pro Met Glu Val 
        275                 280                 285             


Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr Ser Leu Lys Val 
    290                 295                 300                 


Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr Asn Ile Thr Leu 
305                 310                 315                 320 


Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu Ala Pro Arg Val 
                325                 330                 335     


Thr Glu Thr His Phe Lys Glu Leu Thr Pro Gly Arg Leu Tyr Gln Val 
            340                 345                 350         


Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln Arg Met Ala Val 
        355                 360                 365             


Gly Arg Thr Phe Pro Leu Pro Val Leu Gln Leu Arg Val Lys His Ala 
    370                 375                 380                 


Asn Glu Thr Ser Leu Ser Ile Ile Trp Gln Pro Pro Val Ala Glu Trp 
385                 390                 395                 400 


Glu Glu Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Arg Leu Ile His 
                405                 410                 415     


Lys Ser Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val 
            420                 425                 430         


Pro Gly Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu 
        435                 440                 445             


Lys Asn Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr 
    450                 455                 460                 


Asp Leu His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn 
465                 470                 475                 480 


Trp Thr Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile 
                485                 490                 495     


His Glu Asn Val Val Ile Lys Asn Glu Ser Ile Pro Ser Glu Thr Ser 
            500                 505                 510         


Gly Tyr Asn Phe His Phe Leu Lys Ser Gly Ser Leu Tyr Ser Val Val 
        515                 520                 525             


Val Thr Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu 
    530                 535                 540                 


Gly Arg Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser 
545                 550                 555                 560 


Gly Arg Asn Asp Tyr Leu Ser Val Ser Trp Leu Pro Ala Pro Gly Asp 
                565                 570                 575     


Val Asp Asn Tyr Glu Val Thr Leu Ser His Asp Gly Arg Val Val Gln 
            580                 585                 590         


Ser Leu Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu 
        595                 600                 605             


Thr Pro Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys 
    610                 615                 620                 


Tyr Glu Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val 
625                 630                 635                 640 


Gln Gly Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val 
                645                 650                 655     


Ser Trp Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile 
            660                 665                 670         


Lys Asn Lys Asn Asn Phe Ile Glu Thr Lys Ser Ile Pro Lys Ser Glu 
        675                 680                 685             


Asn Glu Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val 
    690                 695                 700                 


Thr Val Thr Thr Lys Ser Gly Gln Tyr Glu Ala Ser Glu Gln Gly Asn 
705                 710                 715                 720 


Gly Arg Thr Gly Gly Gly His His His His His His His His His His 
                725                 730                 735     


<210> 42
<211> 2210
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgag       60

cggtgcaact ttaccctggc cgagtccaag gcctcctccc actccgtgtc tatccggtgg      120

cggatctggg gctccccctg caacttcaac ctgacctact cctccgatac cctgggcgct      180

gcctcctgtc ctcctttccg gctggacaac accacctacg gctgcaacct gcaggatctg      240

caggccggca ccatctacaa cttccggatc gtgtccctgg acggcgagga acggacagtg      300

gtgctgcaga ccgatcctct gccccctgcc agattcggcg tgtccaaaga aaagaccacc      360

tccacctccc tgcacgtgtg gtggacccct agccctggca aagtgacctc ctacgaggtg      420

cagctgttcg acgagaacaa ccagaaaatc cagggcgtgc agatccagga atccacctcc      480

tggaacaagt acaccttctt caatctgacc gccggctcca agtacaacat caccatcacc      540

gccgtgtccg gcggcaagag atcctcctcc gtgtacacca acggctccac cgtgcccagc      600

cccgtgaagg acatcggcat ctccaccaag gccaactccc tgctggtgtc ctggtcccac      660

ggctccggca acgtggaacg gtacagactg atgctgatgg acaagggcat cctggtgcac      720

ggcagcgtgg tggatagaca ggccacctcc tacaccttca acggcctgac ccccggctac      780

ctgtataacc tgaccgtcgt gaccgaggcc gctggactgc agaactacaa gtggaagctc      840

gtgcggaccg cccccatgga agtgtccaac ctgaaagtga ccaacgacgg ctccctgacc      900

tctctgaaag tgaagtggca gaggccccct ggcaatgtgg acagctacaa tatcaccctg      960

tcccacaagg gcaccatcaa agaatcccgg gtgctggccc ccagagtgac cgagacacac     1020

ttcaaagagc tgacccctgg ccggctgtac caagtgaccg tgtcctgtgt gtctggcgag     1080

ctgtctgccc agagaatggc cgtgggcaga accttccctc tgcccgtgct gcagctgaga     1140

gtgaagcacg ccaacgagac atccctgtcc atcatctggc agccccctgt ggccgagtgg     1200

gaagagtaca tcatcagcct ggccgaccgg gacctgcggc tgatccacaa gtccctgagc     1260

aaggacgcca aagagttcac cttcaccgac ctggtgcctg gccggaagta catggccacc     1320

gtgacctcca tctccggcga cctgaagaac tcctccagcg tgaagggcag gaccgtgcct     1380

gcccaagtga cagacctgca tgtggccaac cagggcatga cctccagcct gttcaccaac     1440

tggacccagg ctcagggcga cgtggaattc taccaggtgc tgctgatcca tgagaacgtc     1500

gtgatcaaga acgagtccat cccctccgag acaagcggct acaactttca cttcctgaag     1560

tccggcagcc tgtactccgt ggtcgtgacc acagtgtccg ggggcatctc ctctagaagg     1620

tggtggtgga aggccgcacc gtgcctagtt cagtgtcagg cgtgaccgtg aacaacagcg     1680

gccggaacga ctacctgtcc gtgtcttggc tgcctgcccc tggggacgtg gacaactacg     1740

aagtgaccct gtctcacgac ggccgggtgg tgcagtctct cgtgatcgct aagtccgtgc     1800

gcgagtgctc cttcagcagc ctgacacctg gcagactgta taccgtgacc atcaccacca     1860

gatccgggaa gtacgagaac cacagcttct cccaggaacg aaccgtgccc gacaaggtgc     1920

agggcgtgtc agtgtctaac tccgccagat ctgactacct gagagtgtcc tgggtgcacg     1980

ccaccggcga cttcgaccat tatgaagtga caatcaagaa caagaacaac ttcatcgaga     2040

caaagagcat ccccaagtcc gagaacgagt gcgtgttcgt gcagctggtg ccaggcaggc     2100

tgtattctgt gacagtgacc accaagtccg gccagtacga ggcctctgag cagggcaatg     2160

gcagaaccgg cggtggacac caccatcatc accatcacca ccatcactag                2210


<210> 43
<211> 971
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
            20                  25                  30          


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
        35                  40                  45              


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
    50                  55                  60                  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
65                  70                  75                  80  


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
                85                  90                  95      


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
            100                 105                 110         


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
        115                 120                 125             


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
    130                 135                 140                 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
145                 150                 155                 160 


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
                165                 170                 175     


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
            180                 185                 190         


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
        195                 200                 205             


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
    210                 215                 220                 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
225                 230                 235                 240 


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
                245                 250                 255     


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
            260                 265                 270         


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
        275                 280                 285             


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
    290                 295                 300                 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
305                 310                 315                 320 


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
                325                 330                 335     


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
            340                 345                 350         


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
        355                 360                 365             


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
    370                 375                 380                 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
385                 390                 395                 400 


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
                405                 410                 415     


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
            420                 425                 430         


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
        435                 440                 445             


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
    450                 455                 460                 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
465                 470                 475                 480 


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
                485                 490                 495     


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
            500                 505                 510         


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
        515                 520                 525             


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
    530                 535                 540                 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
545                 550                 555                 560 


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
                565                 570                 575     


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
            580                 585                 590         


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
        595                 600                 605             


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
    610                 615                 620                 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
625                 630                 635                 640 


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
                645                 650                 655     


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
            660                 665                 670         


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
        675                 680                 685             


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
    690                 695                 700                 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
705                 710                 715                 720 


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
                725                 730                 735     


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
            740                 745                 750         


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
        755                 760                 765             


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
    770                 775                 780                 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
785                 790                 795                 800 


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
                805                 810                 815     


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
            820                 825                 830         


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
        835                 840                 845             


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
    850                 855                 860                 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
865                 870                 875                 880 


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
                885                 890                 895     


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
            900                 905                 910         


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
        915                 920                 925             


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
    930                 935                 940                 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Gly 
945                 950                 955                 960 


Gly His His His His His His His His His His 
                965                 970     


<210> 44
<211> 2916
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgca       60

ggtggcaccc ctagtccaat tcctgaccct tcagtagcaa ctgttgccac aggggaaaat      120

ggcataacgc agatcagcag tacagcagaa tcctttcata aacagaatgg aactggaaca      180

cctcaggtgg aaacaaacac cagtgaggat ggtgaaagct ctggagccaa cgatagttta      240

agaacacctg aacaaggatc taatgggact gatggggcat ctcaaaaaac tcccagtagc      300

actgggccca gtcctgtgtt tgacattaaa gctgtttcca tcagtccaac caatgtgatc      360

ttaacttgga aaagtaatga cacagctgct tctgagtaca agtatgtagt aaagcataag      420

atggaaaatg agaagacaat tactgttgtg catcaaccat ggtgtaacat cacaggctta      480

cgtccagcga cttcatatgt attctccatc actccaggaa taggcaatga gacttgggga      540

gatcccagag tcataaaagt catcacagag ccgatcccag tttctgatct ccgtgttgcc      600

ctcacgggtg tgaggaaggc tgctctctcc tggagcaatg gcaatggcac tgcctcctgc      660

cgggttcttc ttgaaagcat tggaagccat gaggagttga ctcaagactc aagacttcag      720

gtcaatatct cgggcctgaa gccaggggtt caatacaaca tcaacccgta tcttctacaa      780

tcaaataaga caaagggaga ccccttgggc acagaaggtg gcttggatgc cagcaataca      840

gagagaagcc gggcagggag ccccaccgcc cctgtgcatg atgagtccct cgtgggacct      900

gtggacccat cctccggcca gcagtcccga gacacggaag tcctgcttgt cgggttagag      960

cctggcaccc gatacaatgc caccgtttat tcccaagcag cgaatggcac agaaggacag     1020

ccccaggcca tagagttcag gacaaatgct attcaggttt ttgacgtcac cgctgtgaac     1080

atcagtgcca caagcctgac cctgatctgg aaagtcagcg ataacgagtc gtcatctaac     1140

tatacctaca agatacatgt ggcgggggag acagattctt ccaatctcaa cgtcagtgag     1200

cctcgcgctg tcatccccgg actccgctcc agcaccttct acaacatcac agtgtgtcct     1260

gtcctaggtg acatcgaggg cacgccgggc ttcctccaag tgcacacccc ccctgttcca     1320

gtttctgact tccgagtgac agtggtcagc acgacggaga tcggcttagc atggagcagc     1380

catgatgcag aatcatttca gatgcatatc acacaggagg gagctggcaa ttctcgggta     1440

gaaataacca ccaaccaaag tattatcatt ggtggcttgt tccctggaac caagtattgc     1500

tttgaaatag ttccaaaagg accaaatggg actgaagggg catctcggac agtttgcaat     1560

agaactgttc ccagtgcagt gtttgacatc cacgtggtct acgtcaccac cacggagatg     1620

tggctggact ggaagagccc tgacggtgct tccgagtatg tctaccattt agtcatagag     1680

tccaagcatg gctctaacca cacaagcacg tatgacaaag cgattactct ccagggcctg     1740

attccgggca ccttatataa catcaccatc tctccagaag tggaccacgt ctggggggac     1800

cccaactcca ctgcacagta cacacggccc agcaatgtgt ccaacattga tgtaagtacc     1860

aacaccacag cagcaacttt aagttggcag aactttgatg acgcctctcc cacgtactcc     1920

tactgccttc ttattgagaa ggctggaaat tccagcaacg caacacaagt agtcacggac     1980

attggaatta ctgacgctac agtcactgaa ttaatacctg gctcatcata cacagtggag     2040

atctttgcac aagtagggga tgggatcaag tcactggaac ctggccggaa gtcattctgt     2100

acagatcctg cgtccatggc ctccttcgac tgcgaagtgg tccccaaaga gccagccctg     2160

gttctcaaat ggacctgccc tcctggcgcc aatgcaggct ttgagctgga ggtcagcagt     2220

ggagcctgga acaatgcgac ccacctggag agctgctcct ctgagaatgg cactgagtat     2280

agaacggaag tcacgtattt gaatttttct acctcgtaca acatcagcat caccactgtg     2340

tcctgtggaa agatggcagc ccccacccgg aacacctgca ctactggcat cacagatccc     2400

cctcctccag atggatcccc taatattaca tctgtcagtc acaattcagt aaaggtcaag     2460

ttcagtggat ttgaagccag ccacggaccc atcaaagcct atgctgtcat tctcaccacc     2520

ggggaagctg gtcacccttc tgcagatgtc ctgaaataca cgtatgagga tttcaaaaag     2580

ggagcctcag atacttatgt gacatacctc ataagaacag aagaaaaggg acgttctcag     2640

agcttgtctg aagttttgaa atatgaaatt gacgttggga atgagtcaac cacacttggt     2700

tattacaatg ggaagctgga acctctgggc tcctaccggg cttgtgtggc tggcttcacc     2760

aacattacct tccaccctca aaacaagggg ctcattgatg gggctgagag ctatgtgtcc     2820

ttcagtcgct actcagatgc tgtttccttg ccccaggatc caggtgtcat ctgtggcggt     2880

ggacaccacc atcatcacca tcaccaccat cactag                               2916


<210> 45
<211> 1621
<212> PRT
<213> Homo sapiens

<400> 45
Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu 
1               5                   10                  15      


Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala 
            20                  25                  30          


Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu 
        35                  40                  45              


Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly 
    50                  55                  60                  


Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile 
                85                  90                  95      


Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro 
            100                 105                 110         


Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu 
        115                 120                 125             


His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val 
    130                 135                 140                 


Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly 
                165                 170                 175     


Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser 
            180                 185                 190         


Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp 
        195                 200                 205             


Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His 
    210                 215                 220                 


Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly 
225                 230                 235                 240 


Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala 
                245                 250                 255     


Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr 
            260                 265                 270         


Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala 
        275                 280                 285             


Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr 
    290                 295                 300                 


Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr 
305                 310                 315                 320 


Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu 
                325                 330                 335     


Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg 
            340                 345                 350         


Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln 
        355                 360                 365             


Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu 
    370                 375                 380                 


Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro 
385                 390                 395                 400 


Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser 
                405                 410                 415     


Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val 
            420                 425                 430         


Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val 
        435                 440                 445             


Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg 
    450                 455                 460                 


Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu 
465                 470                 475                 480 


Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys 
                485                 490                 495     


Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser 
            500                 505                 510         


Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly 
        515                 520                 525             


Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn 
    530                 535                 540                 


Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu 
545                 550                 555                 560 


His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr 
                565                 570                 575     


Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu 
            580                 585                 590         


Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr 
        595                 600                 605             


Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr 
    610                 615                 620                 


Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg 
625                 630                 635                 640 


Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg 
                645                 650                 655     


Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp 
            660                 665                 670         


Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu 
        675                 680                 685             


Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro 
    690                 695                 700                 


Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu 
705                 710                 715                 720 


Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly 
                725                 730                 735     


Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp 
            740                 745                 750         


Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn 
        755                 760                 765             


Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu 
    770                 775                 780                 


Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val 
785                 790                 795                 800 


Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg 
                805                 810                 815     


Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr 
            820                 825                 830         


Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln 
        835                 840                 845             


Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe 
    850                 855                 860                 


His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro 
865                 870                 875                 880 


Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln 
                885                 890                 895     


Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn 
            900                 905                 910         


Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp 
        915                 920                 925             


Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg 
    930                 935                 940                 


His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu 
945                 950                 955                 960 


His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile 
                965                 970                 975     


Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg 
            980                 985                 990         


Thr Val Pro Ala Ser Val Gln Gly  Val Ile Ala Asp Asn  Ala Tyr Ser 
        995                 1000                 1005             


Ser Tyr  Ser Leu Ile Val Ser  Trp Gln Lys Ala Ala  Gly Val Ala 
    1010                 1015                 1020             


Glu Arg  Tyr Asp Ile Leu Leu  Leu Thr Glu Asn Gly  Ile Leu Leu 
    1025                 1030                 1035             


Arg Asn  Thr Ser Glu Pro Ala  Thr Thr Lys Gln His  Lys Phe Glu 
    1040                 1045                 1050             


Asp Leu  Thr Pro Gly Lys Lys  Tyr Lys Ile Gln Ile  Leu Thr Val 
    1055                 1060                 1065             


Ser Gly  Gly Leu Phe Ser Lys  Glu Ala Gln Thr Glu  Gly Arg Thr 
    1070                 1075                 1080             


Val Pro  Ala Ala Val Thr Asp  Leu Arg Ile Thr Glu  Asn Ser Thr 
    1085                 1090                 1095             


Arg His  Leu Ser Phe Arg Trp  Thr Ala Ser Glu Gly  Glu Leu Ser 
    1100                 1105                 1110             


Trp Tyr  Asn Ile Phe Leu Tyr  Asn Pro Asp Gly Asn  Leu Gln Glu 
    1115                 1120                 1125             


Arg Ala  Gln Val Asp Pro Leu  Val Gln Ser Phe Ser  Phe Gln Asn 
    1130                 1135                 1140             


Leu Leu  Gln Gly Arg Met Tyr  Lys Met Val Ile Val  Thr His Ser 
    1145                 1150                 1155             


Gly Glu  Leu Ser Asn Glu Ser  Phe Ile Phe Gly Arg  Thr Val Pro 
    1160                 1165                 1170             


Ala Ser  Val Ser His Leu Arg  Gly Ser Asn Arg Asn  Thr Thr Asp 
    1175                 1180                 1185             


Ser Leu  Trp Phe Asn Trp Ser  Pro Ala Ser Gly Asp  Phe Asp Phe 
    1190                 1195                 1200             


Tyr Glu  Leu Ile Leu Tyr Asn  Pro Asn Gly Thr Lys  Lys Glu Asn 
    1205                 1210                 1215             


Trp Lys  Asp Lys Asp Leu Thr  Glu Trp Arg Phe Gln  Gly Leu Val 
    1220                 1225                 1230             


Pro Gly  Arg Lys Tyr Val Leu  Trp Val Val Thr His  Ser Gly Asp 
    1235                 1240                 1245             


Leu Ser  Asn Lys Val Thr Ala  Glu Ser Arg Thr Ala  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Leu Met Ser Phe Ala  Asp Ile Ala Asn Thr  Ser Leu Ala 
    1265                 1270                 1275             


Ile Thr  Trp Lys Gly Pro Pro  Asp Trp Thr Asp Tyr  Asn Asp Phe 
    1280                 1285                 1290             


Glu Leu  Gln Trp Leu Pro Arg  Asp Ala Leu Thr Val  Phe Asn Pro 
    1295                 1300                 1305             


Tyr Asn  Asn Arg Lys Ser Glu  Gly Arg Ile Val Tyr  Gly Leu Arg 
    1310                 1315                 1320             


Pro Gly  Arg Ser Tyr Gln Phe  Asn Val Lys Thr Val  Ser Gly Asp 
    1325                 1330                 1335             


Ser Trp  Lys Thr Tyr Ser Lys  Pro Ile Phe Gly Ser  Val Arg Thr 
    1340                 1345                 1350             


Lys Pro  Asp Lys Ile Gln Asn  Leu His Cys Arg Pro  Gln Asn Ser 
    1355                 1360                 1365             


Thr Ala  Ile Ala Cys Ser Trp  Ile Pro Pro Asp Ser  Asp Phe Asp 
    1370                 1375                 1380             


Gly Tyr  Ser Ile Glu Cys Arg  Lys Met Asp Thr Gln  Glu Val Glu 
    1385                 1390                 1395             


Phe Ser  Arg Lys Leu Glu Lys  Glu Lys Ser Leu Leu  Asn Ile Met 
    1400                 1405                 1410             


Met Leu  Val Pro His Lys Arg  Tyr Leu Val Ser Ile  Lys Val Gln 
    1415                 1420                 1425             


Ser Ala  Gly Met Thr Ser Glu  Val Val Glu Asp Ser  Thr Ile Thr 
    1430                 1435                 1440             


Met Ile  Asp Arg Pro Pro Pro  Pro Pro Pro His Ile  Arg Val Asn 
    1445                 1450                 1455             


Glu Lys  Asp Val Leu Ile Ser  Lys Ser Ser Ile Asn  Phe Thr Val 
    1460                 1465                 1470             


Asn Cys  Ser Trp Phe Ser Asp  Thr Asn Gly Ala Val  Lys Tyr Phe 
    1475                 1480                 1485             


Thr Val  Val Val Arg Glu Ala  Asp Gly Ser Asp Glu  Leu Lys Pro 
    1490                 1495                 1500             


Glu Gln  Gln His Pro Leu Pro  Ser Tyr Leu Glu Tyr  Arg His Asn 
    1505                 1510                 1515             


Ala Ser  Ile Arg Val Tyr Gln  Thr Asn Tyr Phe Ala  Ser Lys Cys 
    1520                 1525                 1530             


Ala Glu  Asn Pro Asn Ser Asn  Ser Lys Ser Phe Asn  Ile Lys Leu 
    1535                 1540                 1545             


Gly Ala  Glu Met Glu Ser Leu  Gly Gly Lys Cys Asp  Pro Thr Gln 
    1550                 1555                 1560             


Gln Lys  Phe Cys Asp Gly Pro  Leu Lys Pro His Thr  Ala Tyr Arg 
    1565                 1570                 1575             


Ile Ser  Ile Arg Ala Phe Thr  Gln Leu Phe Asp Glu  Asp Leu Lys 
    1580                 1585                 1590             


Glu Phe  Thr Lys Pro Leu Tyr  Ser Asp Thr Phe Phe  Ser Leu Pro 
    1595                 1600                 1605             


Ile Thr  Thr Glu Ser Glu Pro  Leu Phe Gly Ala Ile  Glu 
    1610                 1615                 1620     


<210> 46
<211> 89
<212> PRT
<213> Homo sapiens

<400> 46
Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala Glu Ser Lys Ala 
1               5                   10                  15      


Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu Gly Ser Pro Cys 
            20                  25                  30          


Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly Ala Ala Leu Cys 
        35                  40                  45              


Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys Asn Leu Gln Asp 
    50                  55                  60                  


Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile Ser Leu Asp Glu 
65                  70                  75                  80  


Glu Arg Thr Val Val Leu Gln Thr Asp 
                85                  


<210> 47
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ala Gln Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210> 48
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Gln Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 49

<400> 49
000


<210> 50
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Asn 
            20                  25                  30          


Ala Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ala Gln Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Ser Ser Ala Trp Ile Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210> 51
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Gln Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 52
His His His His His His 
1               5       


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 53
His His His His His His His His His His 
1               5                   10  


