               SEQUENCE LISTING

<110> Università di Pavia

<120> Mutated form of NADPH Oxidases

<130> PR16008

<160> 12

<170> BiSSAP 1.3.6

<210> 1
<211> 2877
<212> DNA
<213> Cylindrospermum stagnale


<400> 1
atgggtttgt tgactgtttt gtccttgaag taccacaacg agttcttgac tagaactgag      60

atcaacatca tcgttgacac tccaaagaaa actttggaag agttgagaag agttttcact     120

cagatcgcta aagaggacaa gcagattgac caggctgagt tcaagtctgc tttgggtttg     180

aaggacgagt acttcgttga cagattgttc tccatcttcg acactgactc ctccggtact     240

atcaagatcg aggaattttt gactactgtt gagaacttgg ttttcgctac ttccgaagag     300

aagttgcagt tcgcttacga gttgcacgat gttaacggtg acggttgtat tgagaaggct     360

gagatctccc acttgatcac tgcttcattg aaagagaaca acttgtcctt ctcaccagag     420

cagatcaacg agttggttga cttgttgttc agagaggctg acgctgacaa gtccggtgaa     480

atttctttcg ctgagtttaa gggtttgatc gagaagttcc cagacttgat cgaggctatg     540

actgtttccc caatctcctg gttgaagcca cacaagcaag actccattgc tgttttgcca     600

aaagaaagaa tggactccca gaaggcttac atcaagtact acatcgaaaa caactgggtt     660

aagatcgctt tcttggcttt gtatgttttc gttaacatgt ttttcttcat gtccgctgtt     720

gaaaagtacg agtcccaggg tgctaacttg tacgttcaga ttgctagagg ttgtggtgct     780

actttgaact tgaacggtgc tttgatcttg atcccaatgt tgagacactt catgacttgg     840

ttgagaaaga ctactatcaa caactacatc ccaatcgacg agtccatcga gttccacaag     900

ttggttggtc aggttatgtt cgctttggct atcgttcata ctggtgctca ctttttgaac     960

tacactactt tgccaatccc attcgctcag tccttgttcg gtactaaggc tggtatttcc    1020

ggtttcctgt tgttgttggt tttcatcatc atgtgggtta ctgctcaggc tccaatcaga    1080

aagggtggta agtttgcttt gttctacatt gctcacatgg gttacgtttt gtggtttgct    1140

ttggctttga tccacggtcc agttttctgg cagtgggttt tgttgccagt tgttggattc    1200

attattgagt tggttatcag atggaaaact acaaaagagc caactttcgt tgttaacgct    1260

tccttgttgc catccaaggt tttgggattg caggttcaaa gaccacagtc cttcaactac    1320

caaccaggtg actacttgtt catcaagtgt ccaggtatct ccaagttcga gtggcaccca    1380

ttcactattt cttccgctcc agaaatgcca gacgttttga cattgcacat cagagctgtt    1440

ggttcttgga ctggtaagtt gtaccagttg atcagagaac agagagaaga gtggatcaga    1500

tccggttctt ctcaatcctt gccaggtgtt ccagtttaca tcgatggtcc atacggtact    1560

ccatccactc acattttcga gtccaagtac gctatcttga tctgtgctgg tatcggtgtt    1620

actccattcg cttccatctt gaagtccatc ttgcacagaa accagcagaa cccagctaag    1680

atgccattga agaaggttca cttctactgg ttgaatagag agcaaaaggc tttcgagtgg    1740

ttcgttgagt tgttgtccaa gattgaggct gaggacacta acaatttgtt cgacttgaac    1800

ttgtacttga caggtgctca gcaaaagtcc gacatgaagt cctccacttt gttcgttgct    1860

atggacttga tgcaccaaga gactaaggtt gatttgatca caggtttgaa gtctagaact    1920

aagactggta gaccagactg ggaagagatt ttcaaggacg ttgctaagca acacgctcca    1980

gacaacgttg aggttttctt ctgtggtcca actggattgg ctttgcagtt gagacatttg    2040

tgtactaagt acggtttcgg ttacagaaaa gaaaatttcc catggctcga gttggaggtt    2100

ttgttccaag gtccagctgc tatggcttct aagggtgaag agttgtttac tggtgttgtt    2160

ccaattttgg ttgagttgga cggtgacgtt aacggacaca agttctctgt ttctggtgaa    2220

ggtgagggtg acgctactta cggaaagttg actttgaagt tcatctgtac tactggaaag    2280

ttgcctgttc cttggccaac tttggttact actttctcct acggtgttca atgtttctcc    2340

agatacccag accacatgaa gagacacgat tttttcaagt ccgctatgcc agagggatac    2400

gttcaagaga gaactatctc cttcaaggat gacggtaact acaagactag agctgaggtt    2460

aagttcgagg gtgacacatt ggttaacaga atcgagttga agggtatcga cttcaaagag    2520

gacggaaaca tcttgggtca taagttggag tacaactaca actcccacaa cgtttacatc    2580

actgctgaca agcaaaagaa cggtatcaag gctaacttta agatcagaca caacatcgag    2640

gacggttccg ttcaattggc tgaccactac caacagaaca ctccaattgg tgacggacca    2700

gttttgttgc ctgacaacca ctacttgtcc actcaatccg ctttgtccaa ggacccaaac    2760

gagaagagag atcacatggt tttgttggag ttcgttactg ctgctggaat cactcacggt    2820

atggacgagt tgtacaaggc tgctcatcat caccaccatc atcaccatca ccacgct       2877


<210> 2
<211> 959
<212> PRT
<213> Cylindrospermum stagnale


<400> 2
Met Gly Leu Leu Thr Val Leu Ser Leu Lys Tyr His Asn Glu Phe Leu 
1               5                   10                  15      
Thr Arg Thr Glu Ile Asn Ile Ile Val Asp Thr Pro Lys Lys Thr Leu 
            20                  25                  30          
Glu Glu Leu Arg Arg Val Phe Thr Gln Ile Ala Lys Glu Asp Lys Gln 
        35                  40                  45              
Ile Asp Gln Ala Glu Phe Lys Ser Ala Leu Gly Leu Lys Asp Glu Tyr 
    50                  55                  60                  
Phe Val Asp Arg Leu Phe Ser Ile Phe Asp Thr Asp Ser Ser Gly Thr 
65                  70                  75                  80  
Ile Lys Ile Glu Glu Phe Leu Thr Thr Val Glu Asn Leu Val Phe Ala 
                85                  90                  95      
Thr Ser Glu Glu Lys Leu Gln Phe Ala Tyr Glu Leu His Asp Val Asn 
            100                 105                 110         
Gly Asp Gly Cys Ile Glu Lys Ala Glu Ile Ser His Leu Ile Thr Ala 
        115                 120                 125             
Ser Leu Lys Glu Asn Asn Leu Ser Phe Ser Pro Glu Gln Ile Asn Glu 
    130                 135                 140                 
Leu Val Asp Leu Leu Phe Arg Glu Ala Asp Ala Asp Lys Ser Gly Glu 
145                 150                 155                 160 
Ile Ser Phe Ala Glu Phe Lys Gly Leu Ile Glu Lys Phe Pro Asp Leu 
                165                 170                 175     
Ile Glu Ala Met Thr Val Ser Pro Ile Ser Trp Leu Lys Pro His Lys 
            180                 185                 190         
Gln Asp Ser Ile Ala Val Leu Pro Lys Glu Arg Met Asp Ser Gln Lys 
        195                 200                 205             
Ala Tyr Ile Lys Tyr Tyr Ile Glu Asn Asn Trp Val Lys Ile Ala Phe 
    210                 215                 220                 
Leu Ala Leu Tyr Val Phe Val Asn Met Phe Phe Phe Met Ser Ala Val 
225                 230                 235                 240 
Glu Lys Tyr Glu Ser Gln Gly Ala Asn Leu Tyr Val Gln Ile Ala Arg 
                245                 250                 255     
Gly Cys Gly Ala Thr Leu Asn Leu Asn Gly Ala Leu Ile Leu Ile Pro 
            260                 265                 270         
Met Leu Arg His Phe Met Thr Trp Leu Arg Lys Thr Thr Ile Asn Asn 
        275                 280                 285             
Tyr Ile Pro Ile Asp Glu Ser Ile Glu Phe His Lys Leu Val Gly Gln 
    290                 295                 300                 
Val Met Phe Ala Leu Ala Ile Val His Thr Gly Ala His Phe Leu Asn 
305                 310                 315                 320 
Tyr Thr Thr Leu Pro Ile Pro Phe Ala Gln Ser Leu Phe Gly Thr Lys 
                325                 330                 335     
Ala Gly Ile Ser Gly Phe Leu Leu Leu Leu Val Phe Ile Ile Met Trp 
            340                 345                 350         
Val Thr Ala Gln Ala Pro Ile Arg Lys Gly Gly Lys Phe Ala Leu Phe 
        355                 360                 365             
Tyr Ile Ala His Met Gly Tyr Val Leu Trp Phe Ala Leu Ala Leu Ile 
    370                 375                 380                 
His Gly Pro Val Phe Trp Gln Trp Val Leu Leu Pro Val Val Gly Phe 
385                 390                 395                 400 
Ile Ile Glu Leu Val Ile Arg Trp Lys Thr Thr Lys Glu Pro Thr Phe 
                405                 410                 415     
Val Val Asn Ala Ser Leu Leu Pro Ser Lys Val Leu Gly Leu Gln Val 
            420                 425                 430         
Gln Arg Pro Gln Ser Phe Asn Tyr Gln Pro Gly Asp Tyr Leu Phe Ile 
        435                 440                 445             
Lys Cys Pro Gly Ile Ser Lys Phe Glu Trp His Pro Phe Thr Ile Ser 
    450                 455                 460                 
Ser Ala Pro Glu Met Pro Asp Val Leu Thr Leu His Ile Arg Ala Val 
465                 470                 475                 480 
Gly Ser Trp Thr Gly Lys Leu Tyr Gln Leu Ile Arg Glu Gln Arg Glu 
                485                 490                 495     
Glu Trp Ile Arg Ser Gly Ser Ser Gln Ser Leu Pro Gly Val Pro Val 
            500                 505                 510         
Tyr Ile Asp Gly Pro Tyr Gly Thr Pro Ser Thr His Ile Phe Glu Ser 
        515                 520                 525             
Lys Tyr Ala Ile Leu Ile Cys Ala Gly Ile Gly Val Thr Pro Phe Ala 
    530                 535                 540                 
Ser Ile Leu Lys Ser Ile Leu His Arg Asn Gln Gln Asn Pro Ala Lys 
545                 550                 555                 560 
Met Pro Leu Lys Lys Val His Phe Tyr Trp Leu Asn Arg Glu Gln Lys 
                565                 570                 575     
Ala Phe Glu Trp Phe Val Glu Leu Leu Ser Lys Ile Glu Ala Glu Asp 
            580                 585                 590         
Thr Asn Asn Leu Phe Asp Leu Asn Leu Tyr Leu Thr Gly Ala Gln Gln 
        595                 600                 605             
Lys Ser Asp Met Lys Ser Ser Thr Leu Phe Val Ala Met Asp Leu Met 
    610                 615                 620                 
His Gln Glu Thr Lys Val Asp Leu Ile Thr Gly Leu Lys Ser Arg Thr 
625                 630                 635                 640 
Lys Thr Gly Arg Pro Asp Trp Glu Glu Ile Phe Lys Asp Val Ala Lys 
                645                 650                 655     
Gln His Ala Pro Asp Asn Val Glu Val Phe Phe Cys Gly Pro Thr Gly 
            660                 665                 670         
Leu Ala Leu Gln Leu Arg His Leu Cys Thr Lys Tyr Gly Phe Gly Tyr 
        675                 680                 685             
Arg Lys Glu Asn Phe Pro Trp Leu Glu Leu Glu Val Leu Phe Gln Gly 
    690                 695                 700                 
Pro Ala Ala Met Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
705                 710                 715                 720 
Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
                725                 730                 735     
Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
            740                 745                 750         
Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
        755                 760                 765             
Val Thr Thr Phe Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
    770                 775                 780                 
His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
785                 790                 795                 800 
Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
                805                 810                 815     
Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
            820                 825                 830         
Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
        835                 840                 845             
Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
    850                 855                 860                 
Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu 
865                 870                 875                 880 
Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
                885                 890                 895     
Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
            900                 905                 910         
Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
        915                 920                 925             
Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu 
    930                 935                 940                 
Tyr Lys Ala Ala His His His His His His His His His His Ala 
945                 950                 955                 

<210> 3
<211> 872
<212> DNA
<213> Cylindrospermum stagnale


<400> 3
ggatccgagc caactttcgt tgttaacgct tccttgttgc catccaaggt tttgggattg      60

caggttcaaa gaccacagtc cttcaactac caaccaggtg actacttgtt catcaagtgt     120

ccaggtatct ccaagttcga gtggcaccca ttcactattt cttccgctcc agaaatgcca     180

gacgttttga cattgcacat cagagctgtt ggttcttgga ctggtaagtt gtaccagttg     240

atcagagaac agagagaaga gtggatcaga tccggttctt ctcaatcctt gccaggtgtt     300

ccagtttaca tcgatggtcc atacggtact ccatccactc acattttcga gtccaagtac     360

gctatcttga tctgtgctgg tatcggtgtt actccattcg cttccatctt gaagtccatc     420

ttgcacagaa accagcagaa cccagctaag atgccattga agaaggttca cttctactgg     480

ttgaatagag agcaaaaggc tttcgagtgg ttcgttgagt tgttgtccaa gattgaggct     540

gaggacacta acaatttgtt cgacttgaac ttgtacttga caggtgctca gcaaaagtcc     600

gacatgaagt cctccacttt gttcgttgct atggacttga tgcaccaaga gactaaggtt     660

gatttgatca caggtttgaa gtctagaact aagactggta gaccagactg ggaagagatt     720

ttcaaggacg ttgctaagca acacgctcca gacaacgttg aggttttctt ctgtggtcca     780

actggattgg ctttgcagtt gagacatttg tgtactaagt acggtttcgg ttacagaaaa     840

gaaaatttcc catggctcga gttggcggcc gc                                   872


<210> 4
<211> 291
<212> PRT
<213> Cylindrospermum stagnale


<400> 4
Gly Ser Glu Pro Thr Phe Val Val Asn Ala Ser Leu Leu Pro Ser Lys 
1               5                   10                  15      
Val Leu Gly Leu Gln Val Gln Arg Pro Gln Ser Phe Asn Tyr Gln Pro 
            20                  25                  30          
Gly Asp Tyr Leu Phe Ile Lys Cys Pro Gly Ile Ser Lys Phe Glu Trp 
        35                  40                  45              
His Pro Phe Thr Ile Ser Ser Ala Pro Glu Met Pro Asp Val Leu Thr 
    50                  55                  60                  
Leu His Ile Arg Ala Val Gly Ser Trp Thr Gly Lys Leu Tyr Gln Leu 
65                  70                  75                  80  
Ile Arg Glu Gln Arg Glu Glu Trp Ile Arg Ser Gly Ser Ser Gln Ser 
                85                  90                  95      
Leu Pro Gly Val Pro Val Tyr Ile Asp Gly Pro Tyr Gly Thr Pro Ser 
            100                 105                 110         
Thr His Ile Phe Glu Ser Lys Tyr Ala Ile Leu Ile Cys Ala Gly Ile 
        115                 120                 125             
Gly Val Thr Pro Phe Ala Ser Ile Leu Lys Ser Ile Leu His Arg Asn 
    130                 135                 140                 
Gln Gln Asn Pro Ala Lys Met Pro Leu Lys Lys Val His Phe Tyr Trp 
145                 150                 155                 160 
Leu Asn Arg Glu Gln Lys Ala Phe Glu Trp Phe Val Glu Leu Leu Ser 
                165                 170                 175     
Lys Ile Glu Ala Glu Asp Thr Asn Asn Leu Phe Asp Leu Asn Leu Tyr 
            180                 185                 190         
Leu Thr Gly Ala Gln Gln Lys Ser Asp Met Lys Ser Ser Thr Leu Phe 
        195                 200                 205             
Val Ala Met Asp Leu Met His Gln Glu Thr Lys Val Asp Leu Ile Thr 
    210                 215                 220                 
Gly Leu Lys Ser Arg Thr Lys Thr Gly Arg Pro Asp Trp Glu Glu Ile 
225                 230                 235                 240 
Phe Lys Asp Val Ala Lys Gln His Ala Pro Asp Asn Val Glu Val Phe 
                245                 250                 255     
Phe Cys Gly Pro Thr Gly Leu Ala Leu Gln Leu Arg His Leu Cys Thr 
            260                 265                 270         
Lys Tyr Gly Phe Gly Tyr Arg Lys Glu Asn Phe Pro Trp Leu Glu Leu 
        275                 280                 285             
Ala Ala Ala 
    290     

<210> 5
<211> 863
<212> DNA
<213> Cylindrospermum stagnale


<400> 5
ggatccgagc caactttcgt tgttaacgct tccttgttgc catccaaggt tttgggattg      60

caggttcaaa gaccacagtc cttcaactac caaccaggtg actacttgtt catcaagtgt     120

ccaggtatct ccaagttcga gtggcaccca ttcactattt cttccgctcc agaaatgcca     180

gacgttttga cattgcacat cagagctgtt ggttcttgga ctggtaagtt gtaccagttg     240

atcagagaac agagagaaga gtggatcaga tccggttctt ctcaatcctt gccaggtgtt     300

ccagtttaca tcgatggtcc atacggtact ccatccactc acattttcga gtccaagtac     360

gctatcttga tctgtgctgg tatcggtgtt actccattcg cttccatctt gaagtccatc     420

ttgcacagaa accagcagaa cccagctaag atgccattga agaaggttca cttctactgg     480

ttgaatagag agcaaaaggc tttcgagtgg ttcgttgagt tgttgtccaa gattgaggct     540

gaggacacta acaatttgtt cgacttgaac ttgtacttga caggtgctca gcaaaagtcc     600

gacatgaagt cctccacttt gttcgttgct atggacttga tgcaccaaga gactaaggtt     660

gatttgatca caggtttgaa gtctagaact aagactggta gaccagactg ggaagagatt     720

ttcaaggacg ttgctaagca acacgctcca gacaacgttg aggttttctt ctgtggtcca     780

actggattgg ctttgcagtt gagacatttg tgtactaagt acggtttcgg ttacagaaaa     840

gaaaatttct aatgagcggc cgc                                             863


<210> 6
<211> 283
<212> PRT
<213> Cylindrospermum stagnale


<400> 6
Gly Ser Glu Pro Thr Phe Val Val Asn Ala Ser Leu Leu Pro Ser Lys 
1               5                   10                  15      
Val Leu Gly Leu Gln Val Gln Arg Pro Gln Ser Phe Asn Tyr Gln Pro 
            20                  25                  30          
Gly Asp Tyr Leu Phe Ile Lys Cys Pro Gly Ile Ser Lys Phe Glu Trp 
        35                  40                  45              
His Pro Phe Thr Ile Ser Ser Ala Pro Glu Met Pro Asp Val Leu Thr 
    50                  55                  60                  
Leu His Ile Arg Ala Val Gly Ser Trp Thr Gly Lys Leu Tyr Gln Leu 
65                  70                  75                  80  
Ile Arg Glu Gln Arg Glu Glu Trp Ile Arg Ser Gly Ser Ser Gln Ser 
                85                  90                  95      
Leu Pro Gly Val Pro Val Tyr Ile Asp Gly Pro Tyr Gly Thr Pro Ser 
            100                 105                 110         
Thr His Ile Phe Glu Ser Lys Tyr Ala Ile Leu Ile Cys Ala Gly Ile 
        115                 120                 125             
Gly Val Thr Pro Phe Ala Ser Ile Leu Lys Ser Ile Leu His Arg Asn 
    130                 135                 140                 
Gln Gln Asn Pro Ala Lys Met Pro Leu Lys Lys Val His Phe Tyr Trp 
145                 150                 155                 160 
Leu Asn Arg Glu Gln Lys Ala Phe Glu Trp Phe Val Glu Leu Leu Ser 
                165                 170                 175     
Lys Ile Glu Ala Glu Asp Thr Asn Asn Leu Phe Asp Leu Asn Leu Tyr 
            180                 185                 190         
Leu Thr Gly Ala Gln Gln Lys Ser Asp Met Lys Ser Ser Thr Leu Phe 
        195                 200                 205             
Val Ala Met Asp Leu Met His Gln Glu Thr Lys Val Asp Leu Ile Thr 
    210                 215                 220                 
Gly Leu Lys Ser Arg Thr Lys Thr Gly Arg Pro Asp Trp Glu Glu Ile 
225                 230                 235                 240 
Phe Lys Asp Val Ala Lys Gln His Ala Pro Asp Asn Val Glu Val Phe 
                245                 250                 255     
Phe Cys Gly Pro Thr Gly Leu Ala Leu Gln Leu Arg His Leu Cys Thr 
            260                 265                 270         
Lys Tyr Gly Phe Gly Tyr Arg Lys Glu Asn Phe 
        275                 280             

<210> 7
<211> 2160
<212> DNA
<213> Homo sapiens


<400> 7
agtgccgagg aggatgccag gtggctccgg tgggtgactc agcagtttaa gaccattgca      60

ggagaagatg gggagatcag cctgcaagaa ttcaaagcag ctctgcatgt gaaagagtcc     120

ttctttgcag agcgattctt tgccctattt gactccgata gaagtggcac catcaccctc     180

caggagctgc aggaggcact gaccctgctc atccatggca gccccatgga caaactcaaa     240

ttcctcttcc aggtgtatga catcgatggc agtggctcca ttgacccgga tgagctgcgc     300

actgtgctgc agtcgtgtct gcgcgagagc gccatctcgc tgcctgacga gaagctggac     360

cagctgacgc tggcgctctt cgaatcggcc gacgcggacg gcaacggggc catcaccttc     420

gaggagctcc gggacgagct gcagcgcttc cccggagtca tggagaacct gaccatcagc     480

gctgcccact ggctgacggc ccccgccccc cgcccacgcc cgcgccggcc gcgccagctg     540

acccgcgcct actggcacaa ccaccgcagc cagctgttct gcctggccac ctatgcaggc     600

ctccacgtgc tgctcttcgg gctggcggcc agcgcgcacc gggacctcgg cgccagcgtc     660

atggtggcca agggctgtgg ccagtgcctc aacttcgact gcagcttcat cgcggtgctg     720

atgctcagac gctgcctcac ctggctgcgg gccacgtggc tggctcaagt cctaccactg     780

gaccagaaca tccagttcca ccagcttatg ggctacgtgg tagtggggct gtccctcgtg     840

cacactgtgg ctcacactgt gaactttgta ctccaggctc aggcggaggc cagccctttc     900

cagttctggg agctgctgct caccacgagg cctggcattg gctgggtaca cggttcggcc     960

tccccgacag gtgtcgctct gctgctgctg ctcctcctca tgttcatctg ctccagttcc    1020

tgcatccgca ggagtggcca ctttgaggtg ttctattgga ctcacctgtc ctacctcctc    1080

gtgtggcttc tgctcatctt tcatgggccc aacttctgga agtggctgct ggtgcctgga    1140

atcttgtttt tcctggagaa ggccatcgga ctggcagtgt cccgcatggc agccgtgtgc    1200

atcatggaag tcaacctcct cccctccaag gtcactcatc tcctcatcaa gcggccccct    1260

ttttttcact atagacctgg tgactacttg tatctgaaca tccccaccat tgctcgctat    1320

gagtggcacc ccttcaccat cagcagtgct cctgagcaga aagacactat ctggctgcac    1380

attcggtccc aaggccagtg gacaaacagg ctgtatgagt ccttcaaggc atcagaccca    1440

ctgggccgtg gttctaagag gctgtcgagg agtgtgacaa tgagaaagag tcaaaggtcg    1500

tccaagggct ctgagatact tttggagaaa cacaaattct gtaacatcaa gtgctacatc    1560

gatgggcctt atgggacccc cacccgcagg atctttgcct ctgagcatgc cgtgctcatc    1620

ggggcaggca tcggcatcac cccctttgct tccattctgc agagtatcat gtacaggcac    1680

cagaaaagaa agcatacttg ccccagctgc cagcactcct ggatcgaagg tgtccaagac    1740

aacatgaagc tccataaggt ggactttatc tggatcaaca gagaccagcg gtctttcgag    1800

tggtttgtga gcctgctgac taaactggag atggaccagg ccgaggaggc tcaatacggc    1860

cgcttcctgg agctgcatat gtacatgaca tctgcactgg gcaagaatga catgaaggcc    1920

attggcctgc agatggccct tgacctcctg gccaacaagg agaagaaaga ctccatcacg    1980

gggctgcaga cgcgcaccca gcctgggcgg cctgactgga gcaaggtgtt ccagaaagtg    2040

gctgctgaga agaagggcaa ggtgcaggtc ttcttctgtg gctccccagc tctggccaag    2100

gtgctgaagg gccattgtga gaagttcggc ttcagatttt tccaagagaa tttcccctgg    2160


<210> 8
<211> 721
<212> PRT
<213> Homo sapiens


<400> 8
Met Ser Ala Glu Glu Asp Ala Arg Trp Leu Arg Trp Val Thr Gln Gln 
1               5                   10                  15      
Phe Lys Thr Ile Ala Gly Glu Asp Gly Glu Ile Ser Leu Gln Glu Phe 
            20                  25                  30          
Lys Ala Ala Leu His Val Lys Glu Ser Phe Phe Ala Glu Arg Phe Phe 
        35                  40                  45              
Ala Leu Phe Asp Ser Asp Arg Ser Gly Thr Ile Thr Leu Gln Glu Leu 
    50                  55                  60                  
Gln Glu Ala Leu Thr Leu Leu Ile His Gly Ser Pro Met Asp Lys Leu 
65                  70                  75                  80  
Lys Phe Leu Phe Gln Val Tyr Asp Ile Asp Gly Ser Gly Ser Ile Asp 
                85                  90                  95      
Pro Asp Glu Leu Arg Thr Val Leu Gln Ser Cys Leu Arg Glu Ser Ala 
            100                 105                 110         
Ile Ser Leu Pro Asp Glu Lys Leu Asp Gln Leu Thr Leu Ala Leu Phe 
        115                 120                 125             
Glu Ser Ala Asp Ala Asp Gly Asn Gly Ala Ile Thr Phe Glu Glu Leu 
    130                 135                 140                 
Arg Asp Glu Leu Gln Arg Phe Pro Gly Val Met Glu Asn Leu Thr Ile 
145                 150                 155                 160 
Ser Ala Ala His Trp Leu Thr Ala Pro Ala Pro Arg Pro Arg Pro Arg 
                165                 170                 175     
Arg Pro Arg Gln Leu Thr Arg Ala Tyr Trp His Asn His Arg Ser Gln 
            180                 185                 190         
Leu Phe Cys Leu Ala Thr Tyr Ala Gly Leu His Val Leu Leu Phe Gly 
        195                 200                 205             
Leu Ala Ala Ser Ala His Arg Asp Leu Gly Ala Ser Val Met Val Ala 
    210                 215                 220                 
Lys Gly Cys Gly Gln Cys Leu Asn Phe Asp Cys Ser Phe Ile Ala Val 
225                 230                 235                 240 
Leu Met Leu Arg Arg Cys Leu Thr Trp Leu Arg Ala Thr Trp Leu Ala 
                245                 250                 255     
Gln Val Leu Pro Leu Asp Gln Asn Ile Gln Phe His Gln Leu Met Gly 
            260                 265                 270         
Tyr Val Val Val Gly Leu Ser Leu Val His Thr Val Ala His Thr Val 
        275                 280                 285             
Asn Phe Val Leu Gln Ala Gln Ala Glu Ala Ser Pro Phe Gln Phe Trp 
    290                 295                 300                 
Glu Leu Leu Leu Thr Thr Arg Pro Gly Ile Gly Trp Val His Gly Ser 
305                 310                 315                 320 
Ala Ser Pro Thr Gly Val Ala Leu Leu Leu Leu Leu Leu Leu Met Phe 
                325                 330                 335     
Ile Cys Ser Ser Ser Cys Ile Arg Arg Ser Gly His Phe Glu Val Phe 
            340                 345                 350         
Tyr Trp Thr His Leu Ser Tyr Leu Leu Val Trp Leu Leu Leu Ile Phe 
        355                 360                 365             
His Gly Pro Asn Phe Trp Lys Trp Leu Leu Val Pro Gly Ile Leu Phe 
    370                 375                 380                 
Phe Leu Glu Lys Ala Ile Gly Leu Ala Val Ser Arg Met Ala Ala Val 
385                 390                 395                 400 
Cys Ile Met Glu Val Asn Leu Leu Pro Ser Lys Val Thr His Leu Leu 
                405                 410                 415     
Ile Lys Arg Pro Pro Phe Phe His Tyr Arg Pro Gly Asp Tyr Leu Tyr 
            420                 425                 430         
Leu Asn Ile Pro Thr Ile Ala Arg Tyr Glu Trp His Pro Phe Thr Ile 
        435                 440                 445             
Ser Ser Ala Pro Glu Gln Lys Asp Thr Ile Trp Leu His Ile Arg Ser 
    450                 455                 460                 
Gln Gly Gln Trp Thr Asn Arg Leu Tyr Glu Ser Phe Lys Ala Ser Asp 
465                 470                 475                 480 
Pro Leu Gly Arg Gly Ser Lys Arg Leu Ser Arg Ser Val Thr Met Arg 
                485                 490                 495     
Lys Ser Gln Arg Ser Ser Lys Gly Ser Glu Ile Leu Leu Glu Lys His 
            500                 505                 510         
Lys Phe Cys Asn Ile Lys Cys Tyr Ile Asp Gly Pro Tyr Gly Thr Pro 
        515                 520                 525             
Thr Arg Arg Ile Phe Ala Ser Glu His Ala Val Leu Ile Gly Ala Gly 
    530                 535                 540                 
Ile Gly Ile Thr Pro Phe Ala Ser Ile Leu Gln Ser Ile Met Tyr Arg 
545                 550                 555                 560 
His Gln Lys Arg Lys His Thr Cys Pro Ser Cys Gln His Ser Trp Ile 
                565                 570                 575     
Glu Gly Val Gln Asp Asn Met Lys Leu His Lys Val Asp Phe Ile Trp 
            580                 585                 590         
Ile Asn Arg Asp Gln Arg Ser Phe Glu Trp Phe Val Ser Leu Leu Thr 
        595                 600                 605             
Lys Leu Glu Met Asp Gln Ala Glu Glu Ala Gln Tyr Gly Arg Phe Leu 
    610                 615                 620                 
Glu Leu His Met Tyr Met Thr Ser Ala Leu Gly Lys Asn Asp Met Lys 
625                 630                 635                 640 
Ala Ile Gly Leu Gln Met Ala Leu Asp Leu Leu Ala Asn Lys Glu Lys 
                645                 650                 655     
Lys Asp Ser Ile Thr Gly Leu Gln Thr Arg Thr Gln Pro Gly Arg Pro 
            660                 665                 670         
Asp Trp Ser Lys Val Phe Gln Lys Val Ala Ala Glu Lys Lys Gly Lys 
        675                 680                 685             
Val Gln Val Phe Phe Cys Gly Ser Pro Ala Leu Ala Lys Val Leu Lys 
    690                 695                 700                 
Gly His Cys Glu Lys Phe Gly Phe Arg Phe Phe Gln Glu Asn Phe Pro 
705                 710                 715                 720 
Trp 
    

<210> 9
<211> 2154
<212> DNA
<213> Homo sapiens


<400> 9
agtgccgagg aggatgccag gtggctccgg tgggtgactc agcagtttaa gaccattgca      60

ggagaagatg gggagatcag cctgcaagaa ttcaaagcag ctctgcatgt gaaagagtcc     120

ttctttgcag agcgattctt tgccctattt gactccgata gaagtggcac catcaccctc     180

caggagctgc aggaggcact gaccctgctc atccatggca gccccatgga caaactcaaa     240

ttcctcttcc aggtgtatga catcgatggc agtggctcca ttgacccgga tgagctgcgc     300

actgtgctgc agtcgtgtct gcgcgagagc gccatctcgc tgcctgacga gaagctggac     360

cagctgacgc tggcgctctt cgaatcggcc gacgcggacg gcaacggggc catcaccttc     420

gaggagctcc gggacgagct gcagcgcttc cccggagtca tggagaacct gaccatcagc     480

gctgcccact ggctgacggc ccccgccccc cgcccacgcc cgcgccggcc gcgccagctg     540

acccgcgcct actggcacaa ccaccgcagc cagctgttct gcctggccac ctatgcaggc     600

ctccacgtgc tgctcttcgg gctggcggcc agcgcgcacc gggacctcgg cgccagcgtc     660

atggtggcca agggctgtgg ccagtgcctc aacttcgact gcagcttcat cgcggtgctg     720

atgctcagac gctgcctcac ctggctgcgg gccacgtggc tggctcaagt cctaccactg     780

gaccagaaca tccagttcca ccagcttatg ggctacgtgg tagtggggct gtccctcgtg     840

cacactgtgg ctcacactgt gaactttgta ctccaggctc aggcggaggc cagccctttc     900

cagttctggg agctgctgct caccacgagg cctggcattg gctgggtaca cggttcggcc     960

tccccgacag gtgtcgctct gctgctgctg ctcctcctca tgttcatctg ctccagttcc    1020

tgcatccgca ggagtggcca ctttgaggtg ttctattgga ctcacctgtc ctacctcctc    1080

gtgtggcttc tgctcatctt tcatgggccc aacttctgga agtggctgct ggtgcctgga    1140

atcttgtttt tcctggagaa ggccatcgga ctggcagtgt cccgcatggc agccgtgtgc    1200

atcatggaag tcaacctcct cccctccaag gtcactcatc tcctcatcaa gcggccccct    1260

ttttttcact atagacctgg tgactacttg tatctgaaca tccccaccat tgctcgctat    1320

gagtggcacc ccttcaccat cagcagtgct cctgagcaga aagacactat ctggctgcac    1380

attcggtccc aaggccagtg gacaaacagg ctgtatgagt ccttcaaggc atcagaccca    1440

ctgggccgtg gttctaagag gctgtcgagg agtgtgacaa tgagaaagag tcaaaggtcg    1500

tccaagggct ctgagatact tttggagaaa cacaaattct gtaacatcaa gtgctacatc    1560

gatgggcctt atgggacccc cacccgcagg atctttgcct ctgagcatgc cgtgctcatc    1620

ggggcaggca tcggcatcac cccctttgct tccattctgc agagtatcat gtacaggcac    1680

cagaaaagaa agcatacttg ccccagctgc cagcactcct ggatcgaagg tgtccaagac    1740

aacatgaagc tccataaggt ggactttatc tggatcaaca gagaccagcg gtctttcgag    1800

tggtttgtga gcctgctgac taaactggag atggaccagg ccgaggaggc tcaatacggc    1860

cgcttcctgg agctgcatat gtacatgaca tctgcactgg gcaagaatga catgaaggcc    1920

attggcctgc agatggccct tgacctcctg gccaacaagg agaagaaaga ctccatcacg    1980

gggctgcaga cgcgcaccca gcctgggcgg cctgactgga gcaaggtgtt ccagaaagtg    2040

gctgctgaga agaagggcaa ggtgcaggtc ttcttctgtg gctccccagc tctggccaag    2100

gtgctgaagg gccattgtga gaagttcggc ttcagatttt tccaagagaa ttgg          2154


<210> 10
<211> 719
<212> PRT
<213> Homo sapiens


<400> 10
Met Ser Ala Glu Glu Asp Ala Arg Trp Leu Arg Trp Val Thr Gln Gln 
1               5                   10                  15      
Phe Lys Thr Ile Ala Gly Glu Asp Gly Glu Ile Ser Leu Gln Glu Phe 
            20                  25                  30          
Lys Ala Ala Leu His Val Lys Glu Ser Phe Phe Ala Glu Arg Phe Phe 
        35                  40                  45              
Ala Leu Phe Asp Ser Asp Arg Ser Gly Thr Ile Thr Leu Gln Glu Leu 
    50                  55                  60                  
Gln Glu Ala Leu Thr Leu Leu Ile His Gly Ser Pro Met Asp Lys Leu 
65                  70                  75                  80  
Lys Phe Leu Phe Gln Val Tyr Asp Ile Asp Gly Ser Gly Ser Ile Asp 
                85                  90                  95      
Pro Asp Glu Leu Arg Thr Val Leu Gln Ser Cys Leu Arg Glu Ser Ala 
            100                 105                 110         
Ile Ser Leu Pro Asp Glu Lys Leu Asp Gln Leu Thr Leu Ala Leu Phe 
        115                 120                 125             
Glu Ser Ala Asp Ala Asp Gly Asn Gly Ala Ile Thr Phe Glu Glu Leu 
    130                 135                 140                 
Arg Asp Glu Leu Gln Arg Phe Pro Gly Val Met Glu Asn Leu Thr Ile 
145                 150                 155                 160 
Ser Ala Ala His Trp Leu Thr Ala Pro Ala Pro Arg Pro Arg Pro Arg 
                165                 170                 175     
Arg Pro Arg Gln Leu Thr Arg Ala Tyr Trp His Asn His Arg Ser Gln 
            180                 185                 190         
Leu Phe Cys Leu Ala Thr Tyr Ala Gly Leu His Val Leu Leu Phe Gly 
        195                 200                 205             
Leu Ala Ala Ser Ala His Arg Asp Leu Gly Ala Ser Val Met Val Ala 
    210                 215                 220                 
Lys Gly Cys Gly Gln Cys Leu Asn Phe Asp Cys Ser Phe Ile Ala Val 
225                 230                 235                 240 
Leu Met Leu Arg Arg Cys Leu Thr Trp Leu Arg Ala Thr Trp Leu Ala 
                245                 250                 255     
Gln Val Leu Pro Leu Asp Gln Asn Ile Gln Phe His Gln Leu Met Gly 
            260                 265                 270         
Tyr Val Val Val Gly Leu Ser Leu Val His Thr Val Ala His Thr Val 
        275                 280                 285             
Asn Phe Val Leu Gln Ala Gln Ala Glu Ala Ser Pro Phe Gln Phe Trp 
    290                 295                 300                 
Glu Leu Leu Leu Thr Thr Arg Pro Gly Ile Gly Trp Val His Gly Ser 
305                 310                 315                 320 
Ala Ser Pro Thr Gly Val Ala Leu Leu Leu Leu Leu Leu Leu Met Phe 
                325                 330                 335     
Ile Cys Ser Ser Ser Cys Ile Arg Arg Ser Gly His Phe Glu Val Phe 
            340                 345                 350         
Tyr Trp Thr His Leu Ser Tyr Leu Leu Val Trp Leu Leu Leu Ile Phe 
        355                 360                 365             
His Gly Pro Asn Phe Trp Lys Trp Leu Leu Val Pro Gly Ile Leu Phe 
    370                 375                 380                 
Phe Leu Glu Lys Ala Ile Gly Leu Ala Val Ser Arg Met Ala Ala Val 
385                 390                 395                 400 
Cys Ile Met Glu Val Asn Leu Leu Pro Ser Lys Val Thr His Leu Leu 
                405                 410                 415     
Ile Lys Arg Pro Pro Phe Phe His Tyr Arg Pro Gly Asp Tyr Leu Tyr 
            420                 425                 430         
Leu Asn Ile Pro Thr Ile Ala Arg Tyr Glu Trp His Pro Phe Thr Ile 
        435                 440                 445             
Ser Ser Ala Pro Glu Gln Lys Asp Thr Ile Trp Leu His Ile Arg Ser 
    450                 455                 460                 
Gln Gly Gln Trp Thr Asn Arg Leu Tyr Glu Ser Phe Lys Ala Ser Asp 
465                 470                 475                 480 
Pro Leu Gly Arg Gly Ser Lys Arg Leu Ser Arg Ser Val Thr Met Arg 
                485                 490                 495     
Lys Ser Gln Arg Ser Ser Lys Gly Ser Glu Ile Leu Leu Glu Lys His 
            500                 505                 510         
Lys Phe Cys Asn Ile Lys Cys Tyr Ile Asp Gly Pro Tyr Gly Thr Pro 
        515                 520                 525             
Thr Arg Arg Ile Phe Ala Ser Glu His Ala Val Leu Ile Gly Ala Gly 
    530                 535                 540                 
Ile Gly Ile Thr Pro Phe Ala Ser Ile Leu Gln Ser Ile Met Tyr Arg 
545                 550                 555                 560 
His Gln Lys Arg Lys His Thr Cys Pro Ser Cys Gln His Ser Trp Ile 
                565                 570                 575     
Glu Gly Val Gln Asp Asn Met Lys Leu His Lys Val Asp Phe Ile Trp 
            580                 585                 590         
Ile Asn Arg Asp Gln Arg Ser Phe Glu Trp Phe Val Ser Leu Leu Thr 
        595                 600                 605             
Lys Leu Glu Met Asp Gln Ala Glu Glu Ala Gln Tyr Gly Arg Phe Leu 
    610                 615                 620                 
Glu Leu His Met Tyr Met Thr Ser Ala Leu Gly Lys Asn Asp Met Lys 
625                 630                 635                 640 
Ala Ile Gly Leu Gln Met Ala Leu Asp Leu Leu Ala Asn Lys Glu Lys 
                645                 650                 655     
Lys Asp Ser Ile Thr Gly Leu Gln Thr Arg Thr Gln Pro Gly Arg Pro 
            660                 665                 670         
Asp Trp Ser Lys Val Phe Gln Lys Val Ala Ala Glu Lys Lys Gly Lys 
        675                 680                 685             
Val Gln Val Phe Phe Cys Gly Ser Pro Ala Leu Ala Lys Val Leu Lys 
    690                 695                 700                 
Gly His Cys Glu Lys Phe Gly Phe Arg Phe Phe Gln Glu Asn Trp 
705                 710                 715                 

<210> 11
<211> 1758
<212> DNA
<213> Homo sapiens


<400> 11
atggctgtgt cctggaggag cgctgtgtcc tggaggagct ggctcgccaa cgaaggggtt      60

aaacacctct gcctgttcat ctggctctcc atgaatgtcc tgcttttctg gaaaaccttc     120

ttgctgtata accaagggcc agagtatcac tacctccacc agatgttggg gctaggattg     180

tgtctaagca gagcctcagc atctgttctt aacctcaact gcagccttat ccttttaccc     240

atgtgccgaa cactcttggc ttacctccga ggatcacaga aggttccaag caggagaacc     300

aggagattgt tggataaaag cagaacattc catattacct gtggtgttac tatctgtatt     360

ttctcaggcg tgcatgtggc tgcccatctg gtgaatgccc tcaacttctc agtgaattac     420

agtgaagact ttgttgaact gaatgcagca agataccgag atgaggatcc tagaaaactt     480

ctcttcacaa ctgttcctgg cctgacaggg gtctgcatgg tggtggtgct attcctcatg     540

atcacagcct ctacatatgc aataagagtt tctaactatg atatcttctg gtatactcat     600

aacctcttct ttgtcttcta catgctgctg acgttgcatg tttcaggagg gctgctgaag     660

tatcaaacta atttagatac ccaccctccc ggctgcatca gtcttaaccg aaccagctct     720

cagaatattt ccttaccaga gtatttctca gaacattttc atgaaccttt ccctgaagga     780

ttttcaaaac cggcagagtt tacccagcac aaatttgtga agatttgtat ggaagagccc     840

agattccaag ctaattttcc acagacttgg ctttggattt ctggaccttt gtgcctgtac     900

tgtgccgaaa gactttacag gtatatccgg agcaataagc cagtcaccat catttcggtc     960

ataagtcatc cctcagatgt catggaaatc cgaatggtca aagaaaattt taaagcaaga    1020

cctggtcagt atattactct acattgtccc agtgtatctg cattagaaaa tcatccattt    1080

accctcacaa tgtgtccaac tgaaaccaaa gcaacatttg gggttcatct taaaatagta    1140

ggagactgga cagaacgatt tcgagattta ctactgcctc catctagtca agactccgaa    1200

attctgccct tcattcaatc tagaaattat cccaagctgt atattgatgg tccttttgga    1260

agtccatttg aggaatcact gaactatgag gtcagcctct gcgtggctgg aggcattgga    1320

gtaactccat ttgcatcaat actcaacacc ctgttggatg actggaaacc atacaagctt    1380

agaagactat actttatttg ggtatgcaga gatatccagt ccttccgttg gtttgcagat    1440

ttactctgta tgttgcataa caagttttgg caagagaaca gacctgacta tgtcaacatc    1500

cagctgtacc tcagtcaaac agatgggata cagaagataa ttggagaaaa atatcatgca    1560

ctgaattcaa gactgtttat aggacgtcct cggtggaaac ttttgtttga tgaaatagca    1620

aaatataaca gaggaaaaac agttggtgtt ttctgttgtg gacccaattc actatccaag    1680

actcttcata aactgagtaa ccagaacaac tcatatggga caagatttga atacaataaa    1740

gagtctttca gcccctgg                                                  1758


<210> 12
<211> 580
<212> PRT
<213> Homo sapiens


<400> 12
Met Ala Val Ser Trp Arg Ser Trp Leu Ala Asn Glu Gly Val Lys His 
1               5                   10                  15      
Leu Cys Leu Phe Ile Trp Leu Ser Met Asn Val Leu Leu Phe Trp Lys 
            20                  25                  30          
Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr His Tyr Leu His Gln 
        35                  40                  45              
Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala Ser Ala Ser Val Leu 
    50                  55                  60                  
Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met Cys Arg Thr Leu Leu 
65                  70                  75                  80  
Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser Arg Arg Thr Arg Arg 
                85                  90                  95      
Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr Cys Gly Val Thr Ile 
            100                 105                 110         
Cys Ile Phe Ser Gly Val His Val Ala Ala His Leu Val Asn Ala Leu 
        115                 120                 125             
Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu Leu Asn Ala Ala 
    130                 135                 140                 
Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu Phe Thr Thr Val Pro 
145                 150                 155                 160 
Gly Leu Thr Gly Val Cys Met Val Val Val Leu Phe Leu Met Ile Thr 
                165                 170                 175     
Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr Asp Ile Phe Trp Tyr 
            180                 185                 190         
Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu Leu Thr Leu His Val 
        195                 200                 205             
Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu Asp Thr His Pro Pro 
    210                 215                 220                 
Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln Asn Ile Ser Leu Pro 
225                 230                 235                 240 
Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe Pro Glu Gly Phe Ser 
                245                 250                 255     
Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val Lys Ile Cys Met Glu 
            260                 265                 270         
Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr Trp Leu Trp Ile Ser 
        275                 280                 285             
Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu Tyr Arg Tyr Ile Arg 
    290                 295                 300                 
Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile Ser His Pro Ser Asp 
305                 310                 315                 320 
Val Met Glu Ile Arg Met Val Lys Glu Asn Phe Lys Ala Arg Pro Gly 
                325                 330                 335     
Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser Ala Leu Glu Asn His 
            340                 345                 350         
Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr Lys Ala Thr Phe Gly 
        355                 360                 365             
Val His Leu Lys Ile Val Gly Asp Trp Thr Glu Arg Phe Arg Asp Leu 
    370                 375                 380                 
Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile Leu Pro Phe Ile Gln 
385                 390                 395                 400 
Ser Arg Asn Tyr Pro Lys Leu Tyr Ile Asp Gly Pro Phe Gly Ser Pro 
                405                 410                 415     
Phe Glu Glu Ser Leu Asn Tyr Glu Val Ser Leu Cys Val Ala Gly Gly 
            420                 425                 430         
Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Asn Thr Leu Leu Asp Asp 
        435                 440                 445             
Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr Phe Ile Trp Val Cys Arg 
    450                 455                 460                 
Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp Leu Leu Cys Met Leu His 
465                 470                 475                 480 
Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp Tyr Val Asn Ile Gln Leu 
                485                 490                 495     
Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys Ile Ile Gly Glu Lys Tyr 
            500                 505                 510         
His Ala Leu Asn Ser Arg Leu Phe Ile Gly Arg Pro Arg Trp Lys Leu 
        515                 520                 525             
Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg Gly Lys Thr Val Gly Val 
    530                 535                 540                 
Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys Thr Leu His Lys Leu Ser 
545                 550                 555                 560 
Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe Glu Tyr Asn Lys Glu Ser 
                565                 570                 575     
Phe Ser Pro Trp 
            580 

