                         SEQUENCE LISTING

<110>  The Walter and Eliza Hall Institute of Medical Research
       La Trobe University
       University of Utah Research Foundation
 
<120>  Insulin Analogs

<130>  525952

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  X
<222>  (3)..(3)
<223>  Val or Ala

<220>
<221>  X
<222>  (4)..(4)
<223>  Glu, Asp, Cys or gamma carboxyglutamate

<220>
<221>  X
<222>  (5)..(5)
<223>  Gln, Glu, gamma carboxyglutamate, His or Val

<220>
<221>  X
<222>  (6)..(6)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (7)..(7)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (8)..(8)
<223>  Thr, His, Asp, Gln, Tyr, Lys, Ala or Val

<220>
<221>  X
<222>  (9)..(9)
<223>  Ser, Arg, Asn, Gly, His or Lys

<220>
<221>  X
<222>  (10)..(10)
<223>  Ile, Pro, Tyr, Ala, Ser, Val, Phe, His or Thr

<220>
<221>  X
<222>  (11)..(11)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  Ser or Thr

<220>
<221>  X
<222>  (13)..(13)
<223>  Leu, Asn, Val, Arg or Asp

<220>
<221>  X
<222>  (14)..(14)
<223>  Tyr, Ala, Gln, His, Asp or Glu

<220>
<221>  X
<222>  (15)..(15)
<223>  Gln, Glu or Thr

<220>
<221>  X
<222>  (16)..(16)
<223>  Phe, Leu, or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Glu, Gln, Lys, Arg, Ile, Met, Thr or Ser

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys, Ser, Thr, Asn, Gln or Glu

<220>
<221>  X
<222>  (19)..(19)
<223>  Tyr or Phe

<220>
<221>  X
<222>  (20)..(20)
<223>  Cys, selenocysteine, amidated Cys, or amidated selenocysteine

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn, Pro, His, Ser, Gly, Ala, or is absent

<220>
<221>  X
<222>  (22)..(22)
<223>  Pro, Asn, Thr, Leu, Ser or is absent

<220>
<221>  X
<222>  (23)..(23)
<223>  Thr, Leu, Val, Ser or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Thr, Met, Gln, Leu or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Ser, Leu or is absent

<220>
<221>  X
<222>  (27)..(31)
<223>  Ser or absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Ala, Ser or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Ala, Val or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Ala or is absent

<400>  1

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa 
        


<210>  2
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn, Ser or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser, Asn, Thr, Gln or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Ala, Asp, Gly, Pro, Leu, Phe, or His

<220>
<221>  X
<222>  (4)..(4)
<223>  Ala, Thr, Pro, Asp, Val or Gly

<220>
<221>  X
<222>  (5)..(5)
<223>  Asn, Pro, His, Thr, Arg, Ser or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Glu, Asn, Asp, Arg, Gln or Gly

<220>
<221>  X
<222>  (7)..(7)
<223>  His, Tyr, Arg or Ile

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Thr, Ile, Ser, Leu, Tyr or Lys

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (10)..(10)
<223>  Gly, Gln or Asp

<220>
<221>  X
<222>  (11)..(11)
<223>  Ser, Leu, Gly or Pro

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu, gamma carboxyglutamate, Asp, or Asn

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile, Leu, Asp, Val or Ala

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, Val or Arg

<220>
<221>  X
<222>  (15)..(15)
<223>  Asn, Asp, Ala, Val, Thr, Pro or Glu

<220>
<221>  X
<222>  (16)..(16)
<223>  Ala, Ser, Gln, His, Tyr, Arg or Gly

<220>
<221>  X
<222>  (17)..(17)
<223>  Thr, Tyr, Pro, Leu or Gly

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Met, Val, Gln, Ile, Asp, Gly, Asn or Leu

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln, Gly, Lys, Glu, Arg or Thr

<220>
<221>  X
<222>  (20)..(20)
<223>  Val, Leu or Lys

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Val, Tyr, Phe, His, Gly, Gln, Leu, amidated His, amidated Val or 
       is absent

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Ser, Gly or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Asp, Val or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Gly, Leu, Val or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Phe, Val, Ile or is absent

<220>
<221>  X
<222>  (27)..(27)
<223>  Phe, Asn, Pro, Glu or is absent

<220>
<221>  X
<222>  (28)..(28)
<223>  Tyr, Cys, His or is absent

<220>
<221>  X
<222>  (29)..(29)
<223>  Thr, His, Ile, Leu, Ser, Tyr or is absent

<220>
<221>  X
<222>  (30)..(30)
<223>  Pro, Glu, Leu, Ile, Arg or is absent

<220>
<221>  X
<222>  (31)..(31)
<223>  Ile, Lys or is absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Ala, Asp, Ser, Thr, Lys, Leu, Gln or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Cys or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Glu, Pro, Val or is absent

<220>
<221>  X
<222>  (35)..(35)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (36)..(36)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (37)..(37)
<223>  Glu, Val or is absent

<220>
<221>  X
<222>  (38)..(38)
<223>  Ala, Asp or is absent

<220>
<221>  X
<222>  (39)..(39)
<223>  Ala or is absent

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn, Ser or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser, Asn, Thr, Gln or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Asp, Gly, Pro, Leu, Phe, or His

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr, Pro, Asp, Val or Gly

<220>
<221>  X
<222>  (5)..(5)
<223>  Asn, Pro, His, Thr, Arg, Ser or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Glu, Asn, Asp, Arg, Gln or Gly

<220>
<221>  X
<222>  (7)..(7)
<223>  His, Tyr, Arg or Ile

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Thr, Ile, Ser, Leu, Tyr or Lys

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (10)..(10)
<223>  Gly, Gln or Asp

<220>
<221>  X
<222>  (11)..(11)
<223>  Ser, Leu, Gly or Pro

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu, gamma carboxyglutamate, Asp, or Asn

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile, Leu, Asp, Val or Ala

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, Val or Arg

<220>
<221>  X
<222>  (15)..(15)
<223>  Asn, Asp, Ala, Val, Thr, Pro or Glu

<220>
<221>  X
<222>  (16)..(16)
<223>  Ala, Ser, Gln, His, Tyr, Arg or Gly

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Met, Val, Gln, Ile, Asp, Gly, Asn or Leu

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln, Gly, Lys, Glu, Arg or Thr

<220>
<221>  X
<222>  (20)..(20)
<223>  Val, Leu or Lys

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr, Phe or His

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Ser, Gly or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Asp, Val or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Gly, Leu, Val or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Phe, Val, Ile or is absent

<220>
<221>  X
<222>  (27)..(27)
<223>  Phe, Asn, Pro, Glu or is absent

<220>
<221>  X
<222>  (28)..(28)
<223>  Tyr, Cys, His or is absent

<220>
<221>  X
<222>  (29)..(29)
<223>  Thr, His, Leu, Tyr or is absent

<220>
<221>  X
<222>  (30)..(30)
<223>  Pro, Glu, Leu, Ile, Arg or is absent

<220>
<221>  X
<222>  (31)..(31)
<223>  Ile, Lys or is absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Thr, Lys, Leu, Gln or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Cys or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Glu, Pro, Val or is absent

<220>
<221>  X
<222>  (35)..(35)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (36)..(36)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (37)..(37)
<223>  Glu, Val or is absent

<220>
<221>  X
<222>  (38)..(38)
<223>  Ala, Asp or is absent

<220>
<221>  X
<222>  (39)..(39)
<223>  Ala or is absent

<400>  3

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn, Ser or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser, Asn, Thr, Gln or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Asp, Gly, Pro, Leu, Phe, or His

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr, Pro, Asp, Val or Gly

<220>
<221>  X
<222>  (5)..(5)
<223>  Asn, Pro, His, Thr, Arg, Ser or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Glu, Asn, Asp, Arg, Gln or Gly

<220>
<221>  X
<222>  (7)..(7)
<223>  His, Tyr, Arg or Ile

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Thr, Ile, Ser, Leu, Tyr or Lys

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (10)..(10)
<223>  Gly, Gln or Asp

<220>
<221>  X
<222>  (11)..(11)
<223>  Ser, Leu, Gly or Pro

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu, gamma carboxyglutamate, Asp, or Asn

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile, Leu, Asp, Val or Ala

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, Val or Arg

<220>
<221>  X
<222>  (15)..(15)
<223>  Asn, Asp, Ala, Val, Thr, Pro or Glu

<220>
<221>  X
<222>  (16)..(16)
<223>  Ala, Ser, Gln, His, Tyr, Arg or Gly

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Met, Val, Gln, Ile, Asp, Gly, Asn or Leu

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln, Gly, Lys, Glu, Arg or Thr

<220>
<221>  X
<222>  (20)..(20)
<223>  Val, Leu or Lys

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr, Phe or His

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Ser, Gly or is absent

<220>
<221>  X
<222>  (24)..(39)
<223>  absent

<400>  4

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn, Ser or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser, Asn, Thr, Gln or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Asp, Gly, Pro, Leu, Phe, or His

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr, Pro, Asp, Val or Gly

<220>
<221>  X
<222>  (5)..(5)
<223>  Asn, Pro, His, Thr, Arg, Ser or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Glu, Asn, Asp, Arg, Gln or Gly

<220>
<221>  X
<222>  (7)..(7)
<223>  His, Tyr, Arg or Ile

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Thr, Ile, Ser, Leu, Tyr or Lys

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu, gamma carboxyglutamate, Asp, or Asn

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile, Leu, Asp, Val or Ala

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, Val or Arg

<220>
<221>  X
<222>  (15)..(15)
<223>  Asn, Asp, Ala, Val, Thr, Pro or Glu

<220>
<221>  X
<222>  (16)..(16)
<223>  Ala, Ser, Gln, His, Tyr, Arg or Gly

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Met, Val, Gln, Ile, Asp, Gly, Asn or Leu

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln, Gly, Lys, Glu, Arg or Thr

<220>
<221>  X
<222>  (20)..(20)
<223>  Val, Leu or Lys

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr, Phe or His

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Ser, Gly or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Asp, Val or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Gly, Leu, Val or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Phe, Val, Ile or is absent

<220>
<221>  X
<222>  (27)..(27)
<223>  Phe, Asn, Pro, Glu or is absent

<220>
<221>  X
<222>  (28)..(28)
<223>  Tyr, Cys, His or is absent

<220>
<221>  X
<222>  (29)..(29)
<223>  Thr, His, Leu, Tyr or is absent

<220>
<221>  X
<222>  (30)..(30)
<223>  Pro, Glu, Leu, Ile, Arg or is absent

<220>
<221>  X
<222>  (31)..(31)
<223>  Ile, Lys or is absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Thr, Lys, Leu, Gln or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Cys or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Glu, Pro, Val or is absent

<220>
<221>  X
<222>  (35)..(35)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (36)..(36)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (37)..(37)
<223>  Glu, Val or is absent

<220>
<221>  X
<222>  (38)..(38)
<223>  Ala, Asp or is absent

<220>
<221>  X
<222>  (39)..(39)
<223>  Ala or is absent

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn, Ser or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser, Asn, Thr, Gln or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Asp, Gly, Pro, Leu, Phe, or His

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr, Pro, Asp, Val or Gly

<220>
<221>  X
<222>  (5)..(5)
<223>  Asn, Pro, His, Thr, Arg, Ser or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Glu, Asn, Asp, Arg, Gln or Gly

<220>
<221>  X
<222>  (7)..(7)
<223>  His or Tyr

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Thr, Ile, Ser, Leu, Tyr or Lys

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu, gamma carboxyglutamate, Asp, or Asn

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile, Leu, Asp, Val or Ala

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, Val or Arg

<220>
<221>  X
<222>  (15)..(15)
<223>  Asn, Asp, Ala, Val, Thr, Pro or Glu

<220>
<221>  X
<222>  (16)..(16)
<223>  Ala, Ser, Gln, His, Tyr, Arg or Gly

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Met, Val, Gln, Ile, Asp, Gly, Asn or Leu

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln, Gly, Lys, Glu, Arg or Thr

<220>
<221>  X
<222>  (20)..(20)
<223>  Val or Leu

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr, Phe or His

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Ser, Gly or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Asp, Val or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Gly, Leu, Val or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Phe, Val, Ile or is absent

<220>
<221>  X
<222>  (27)..(27)
<223>  Phe, Asn, Pro, Glu or is absent

<220>
<221>  X
<222>  (28)..(28)
<223>  Tyr, Cys, His or is absent

<220>
<221>  X
<222>  (29)..(29)
<223>  Thr, His, Leu, Tyr or is absent

<220>
<221>  X
<222>  (30)..(30)
<223>  Pro, Glu, Leu, Ile, Arg or is absent

<220>
<221>  X
<222>  (31)..(31)
<223>  Ile, Lys or is absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Thr, Lys, Leu, Gln or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Cys or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Glu, Pro, Val or is absent

<220>
<221>  X
<222>  (35)..(35)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (36)..(36)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (37)..(37)
<223>  Glu, Val or is absent

<220>
<221>  X
<222>  (38)..(38)
<223>  Ala, Asp or is absent

<220>
<221>  X
<222>  (39)..(39)
<223>  Ala or is absent

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr, Asn or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe, Ser or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys, Asn or Gln

<220>
<221>  X
<222>  (7)..(7)
<223>  His or Tyr

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg, Ile or Leu

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Asp, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (13)..(13)
<223>  Val, Ile or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, Ala, Pro, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, Val, Asn or Asp

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser, Gln, Tyr or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr, Asp, Met or Val

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu, Asp, Gln or Lys

<220>
<221>  X
<222>  (20)..(20)
<223>  Leu or Val

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, amidated Cys, selenocysteine or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr or Gly

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Gly or is absent

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20              


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg or Leu

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (20)..(20)
<223>  Leu or Val

<220>
<221>  X
<222>  (22)..(22)
<223>  Tyr

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu, Arg, Gly or is absent

<400>  8

Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Cys Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Cys Xaa Xaa 
            20              


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  X
<222>  (3)..(3)
<223>  Val or Ala

<220>
<221>  X
<222>  (4)..(4)
<223>  Glu, gamma carboxyglutamate or Cys

<220>
<221>  X
<222>  (5)..(5)
<223>  Gln, Glu, gamma carboxyglutamate, His or Val

<220>
<221>  X
<222>  (6)..(7)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (8)..(8)
<223>  Thr, His, Asp, Gln, Tyr, Lys or Val

<220>
<221>  X
<222>  (9)..(9)
<223>  Ser, Arg, Asn, His or Lys

<220>
<221>  X
<222>  (10)..(10)
<223>  Ile, Pro, Tyr, Ala, Ser, Phe, His or Thr

<220>
<221>  X
<222>  (11)..(11)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  Ser or Thr

<220>
<221>  X
<222>  (13)..(13)
<223>  Leu, Asn, Val or Asp

<220>
<221>  X
<222>  (14)..(14)
<223>  Tyr, Ala, Gln, Asp or Glu

<220>
<221>  X
<222>  (15)..(15)
<223>  Gln, Glu or Thr; or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Glu, Lys, Arg, Ile, Met, Thr or Ser

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys, Thr, Asn, Gln or Glu

<220>
<221>  X
<222>  (19)..(19)
<223>  Tyr or Phe

<220>
<221>  X
<222>  (20)..(20)
<223>  Cys, selenocysteine, amidated Cys, or amidated selenocysteine

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn, Pro, His, Ser, Gly, Ala, or is absent

<220>
<221>  X
<222>  (22)..(22)
<223>  Pro, Asn, Thr, Leu, Ser or is absent

<220>
<221>  X
<222>  (23)..(23)
<223>  Thr, Leu, Val, Ser or is absent

<220>
<221>  X
<222>  (24)..(24)
<223>  Arg, Thr, Met, Gln, Leu or is absent

<220>
<221>  X
<222>  (25)..(25)
<223>  Glu, Gly or is absent

<220>
<221>  X
<222>  (26)..(26)
<223>  Ser, Leu or is absent

<220>
<221>  X
<222>  (27)..(31)
<223>  Ser or is absent

<220>
<221>  X
<222>  (32)..(32)
<223>  Ala, Ser or is absent

<220>
<221>  X
<222>  (33)..(33)
<223>  Ala, Val or is absent

<220>
<221>  X
<222>  (34)..(34)
<223>  Ala or is absent

<400>  9

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa 
        


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  X
<222>  (4)..(4)
<223>  Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (5)..(5)
<223>  His or Gln

<220>
<221>  X
<222>  (6)..(7)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (8)..(8)
<223>  His or Thr

<220>
<221>  X
<222>  (9)..(9)
<223>  Arg or Ser

<220>
<221>  X
<222>  (10)..(10)
<223>  Pro or Ile

<220>
<221>  X
<222>  (11)..(11)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (13)..(13)
<223>  Asn or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Ala or Tyr

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu or Gln

<220>
<221>  X
<222>  (16)..(16)
<223>  Phe or Leu

<220>
<221>  X
<222>  (17)..(17)
<223>  Lys or Glu

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys or Asn

<220>
<221>  X
<222>  (20)..(20)
<223>  Cys, selenocysteine, amidated Cys, or amidated selenocysteine

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn or absent

<400>  10

Gly Xaa Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg or Leu

<220>
<221>  X
<222>  (9)..(9)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (20)..(20)
<223>  Leu or Val

<220>
<221>  X
<222>  (21)..(21)
<223>  Cys, selenocysteine, amidated Cys, or amidated selenocysteine

<220>
<221>  X
<222>  (22)..(22)
<223>  Gly or Tyr

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu or Arg

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Cys Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20              


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  X
<222>  (4)..(4)
<223>  Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (5)..(5)
<223>  His or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  His or Thr

<220>
<221>  X
<222>  (9)..(9)
<223>  Arg or Ser

<220>
<221>  X
<222>  (10)..(10)
<223>  Pro or Ile

<220>
<221>  X
<222>  (13)..(13)
<223>  Asn or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Ala or Tyr

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu or Gln

<220>
<221>  X
<222>  (17)..(17)
<223>  Lys or Glu

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys or Asn

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn or absent

<400>  12

Gly Xaa Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg or Leu

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (20)..(20)
<223>  Leu or Val

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu or Arg

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Cys Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Cys Tyr Xaa 
            20              


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (4)..(4)
<223>  Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (5)..(5)
<223>  His or Gln

<220>
<221>  X
<222>  (6)..(7)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (8)..(8)
<223>  His or Thr

<220>
<221>  X
<222>  (9)..(9)
<223>  Arg or Ser

<220>
<221>  X
<222>  (10)..(10)
<223>  Pro or Ile

<220>
<221>  X
<222>  (11)..(11)
<223>  Cys or selenocysteine

<220>
<221>  X
<222>  (13)..(13)
<223>  Asn or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Ala or Tyr

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu or Gln

<220>
<221>  X
<222>  (17)..(17)
<223>  Lys or Glu

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys or Asn

<220>
<221>  X
<222>  (20)..(20)
<223>  Cys, selenocysteine, amidated Cys, or amidated selenocysteine

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn or absent

<400>  14

Gly Val Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (17)..(17)
<223>  Tyr or Leu

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu or Arg

<400>  15

Xaa Xaa Xaa Xaa Xaa Xaa His Arg Cys Gly Ser Xaa Ile Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Leu Cys Tyr Xaa 
            20              


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  16

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (15)..(15)
<223>  aromatic residue or large aliphatic residue

<400>  17

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Xaa Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  18

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (20)..(20)
<223>  aromatic residue or large aliphatic residue

<400>  19

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Xaa Glu 
            20      


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  20

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (15)..(15)
<223>  aromatic residue or large aliphatic residue

<220>
<221>  X
<222>  (20)..(20)
<223>  aromatic residue or large aliphatic residue

<400>  21

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Xaa Tyr 
1               5                   10                  15      


Leu Val Cys Xaa Glu 
            20      


<210>  22
<211>  20
<212>  PRT
<213>  Conus geographus


<220>
<221>  X
<222>  (4)..(4)
<223>  gamma-carboxylated glutamic acid

<220>
<221>  X
<222>  (20)..(20)
<223>  amidated Cys (at N-terminus)

<400>  22

Gly Val Val Xaa His Cys Cys His Arg Pro Cys Ser Asn Ala Glu Phe 
1               5                   10                  15      


Lys Lys Tyr Xaa 
            20  


<210>  23
<211>  23
<212>  PRT
<213>  Conus geographus


<220>
<221>  X
<222>  (5)..(5)
<223>  hydroxyproline

<220>
<221>  X
<222>  (12)..(12)
<223>  gamma-carboxylated glutamic acid

<400>  23

Thr Phe Asp Thr Tyr Lys His Arg Cys Gly Ser Xaa Ile Thr Asn Ser 
1               5                   10                  15      


Tyr Met Asp Leu Cys Tyr Arg 
            20              


<210>  24
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  25
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  25

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  X
<222>  (4)..(4)
<223>  Glu or gamma carboxyglutamate,

<220>
<221>  X
<222>  (5)..(5)
<223>  His or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  His or Thr

<220>
<221>  X
<222>  (9)..(9)
<223>  Arg or Ser

<220>
<221>  X
<222>  (10)..(10)
<223>  Pro or Ile,

<220>
<221>  X
<222>  (13)..(13)
<223>  Asn or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Ala or Tyr

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu or Gln

<220>
<221>  X
<222>  (17)..(17)
<223>  Lys or Glu

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys or Asn

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn or absent

<400>  26

Gly Xaa Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  27
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  Arg or Leu

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (13)..(13)
<223>  Ile or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (20)..(20)
<223>  Leu or Val

<220>
<221>  X
<222>  (22)..(22)
<223>  Gly or Tyr

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu or Arg

<400>  27

Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Cys Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Tyr Xaa Xaa Xaa Cys Xaa Xaa 
            20              


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain


<220>
<221>  X
<222>  (4)..(4)
<223>  Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (5)..(5)
<223>  His or Gln

<220>
<221>  X
<222>  (8)..(8)
<223>  His or Thr

<220>
<221>  X
<222>  (9)..(9)
<223>  Arg or Ser

<220>
<221>  X
<222>  (10)..(10)
<223>  Pro or Ile

<220>
<221>  X
<222>  (13)..(13)
<223>  Asn or Leu

<220>
<221>  X
<222>  (14)..(14)
<223>  Ala or Tyr

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu or Gln

<220>
<221>  X
<222>  (17)..(17)
<223>  Lys or Glu

<220>
<221>  X
<222>  (18)..(18)
<223>  Lys or Asn

<220>
<221>  X
<222>  (21)..(21)
<223>  Asn or absent

<400>  28

Gly Val Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  29
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain


<220>
<221>  X
<222>  (1)..(1)
<223>  Thr or is absent

<220>
<221>  X
<222>  (2)..(2)
<223>  Phe or is absent

<220>
<221>  X
<222>  (3)..(3)
<223>  Phe or Asp

<220>
<221>  X
<222>  (4)..(4)
<223>  Thr or Val

<220>
<221>  X
<222>  (5)..(5)
<223>  Pro, Asn or hydroxyproline

<220>
<221>  X
<222>  (6)..(6)
<223>  Lys or Gln

<220>
<221>  X
<222>  (12)..(12)
<223>  His, Glu or gamma carboxyglutamate

<220>
<221>  X
<222>  (14)..(14)
<223>  Thr, or Val

<220>
<221>  X
<222>  (15)..(15)
<223>  Glu, or Asn

<220>
<221>  X
<222>  (16)..(16)
<223>  Ser or Ala

<220>
<221>  X
<222>  (18)..(18)
<223>  Tyr or Met

<220>
<221>  X
<222>  (19)..(19)
<223>  Leu or Asp

<220>
<221>  X
<222>  (22)..(22)
<223>  Gly or Tyr

<220>
<221>  X
<222>  (23)..(23)
<223>  Glu or Arg

<400>  29

Xaa Xaa Xaa Xaa Xaa Xaa His Arg Cys Gly Ser Xaa Ile Xaa Xaa Xaa 
1               5                   10                  15      


Tyr Xaa Xaa Leu Cys Xaa Xaa 
            20              


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B Chain

<400>  30

Phe Val Asn Gln His Leu Cys Gly Ser Glu Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Tyr Glu Arg 
            20          


<210>  31
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  31

Phe Val Asn Gln His Leu Cys Gly Ser Glu Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Phe Glu Arg 
            20          


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  32

Phe Val Asn Gln His Leu Cys Gly Ser Glu Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Pro Glu Arg 
            20          


<210>  33
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  33

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Tyr Glu Arg 
            20          


<210>  34
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  34

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Phe Glu Arg 
            20          


<210>  35
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  35

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Pro Glu Arg 
            20          


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  36

Phe Val Asn Gln His Leu Cys Gly Ser Gln Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Tyr Glu Arg 
            20          


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  37

Phe Val Asn Gln His Leu Cys Gly Ser Gln Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Phe Glu Arg 
            20          


<210>  38
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B chain

<400>  38

Phe Val Asn Gln His Leu Cys Gly Ser Gln Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Pro Glu Arg 
            20          


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  39

Gly Ile Val Glu Gln Cys Cys His Arg Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  40

Gly Ile Val Glu Gln Cys Cys Tyr Arg Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain

<400>  41

Gly Ile Val Glu Gln Cys Cys Lys Arg Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


