                         SEQUENCE LISTING

<110>  Poseida Therapeutics, Inc.
       Ostertag, Eric
       Shedlock, Devon
 
<120>  CHIMERIC ANTIGEN RECEPTORS AND METHODS FOR USE

<130>  POTH-008/001WO

<150>  62/503,127
<151>  2017-05-08

<150>  62/405,180
<151>  2016-10-06

<150>  62/362,746
<151>  2016-07-15

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  2
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  piggybac transposase

<400>  2

Met Gly Ser Ser Leu Asp Asp Glu His Ile Leu Ser Ala Leu Leu Gln 
1               5                   10                  15      


Ser Asp Asp Glu Leu Val Gly Glu Asp Ser Asp Ser Glu Val Ser Asp 
            20                  25                  30          


His Val Ser Glu Asp Asp Val Gln Ser Asp Thr Glu Glu Ala Phe Ile 
        35                  40                  45              


Asp Glu Val His Glu Val Gln Pro Thr Ser Ser Gly Ser Glu Ile Leu 
    50                  55                  60                  


Asp Glu Gln Asn Val Ile Glu Gln Pro Gly Ser Ser Leu Ala Ser Asn 
65                  70                  75                  80  


Arg Ile Leu Thr Leu Pro Gln Arg Thr Ile Arg Gly Lys Asn Lys His 
                85                  90                  95      


Cys Trp Ser Thr Ser Lys Ser Thr Arg Arg Ser Arg Val Ser Ala Leu 
            100                 105                 110         


Asn Ile Val Arg Ser Gln Arg Gly Pro Thr Arg Met Cys Arg Asn Ile 
        115                 120                 125             


Tyr Asp Pro Leu Leu Cys Phe Lys Leu Phe Phe Thr Asp Glu Ile Ile 
    130                 135                 140                 


Ser Glu Ile Val Lys Trp Thr Asn Ala Glu Ile Ser Leu Lys Arg Arg 
145                 150                 155                 160 


Glu Ser Met Thr Ser Ala Thr Phe Arg Asp Thr Asn Glu Asp Glu Ile 
                165                 170                 175     


Tyr Ala Phe Phe Gly Ile Leu Val Met Thr Ala Val Arg Lys Asp Asn 
            180                 185                 190         


His Met Ser Thr Asp Asp Leu Phe Asp Arg Ser Leu Ser Met Val Tyr 
        195                 200                 205             


Val Ser Val Met Ser Arg Asp Arg Phe Asp Phe Leu Ile Arg Cys Leu 
    210                 215                 220                 


Arg Met Asp Asp Lys Ser Ile Arg Pro Thr Leu Arg Glu Asn Asp Val 
225                 230                 235                 240 


Phe Thr Pro Val Arg Lys Ile Trp Asp Leu Phe Ile His Gln Cys Ile 
                245                 250                 255     


Gln Asn Tyr Thr Pro Gly Ala His Leu Thr Ile Asp Glu Gln Leu Leu 
            260                 265                 270         


Gly Phe Arg Gly Arg Cys Pro Phe Arg Val Tyr Ile Pro Asn Lys Pro 
        275                 280                 285             


Ser Lys Tyr Gly Ile Lys Ile Leu Met Met Cys Asp Ser Gly Thr Lys 
    290                 295                 300                 


Tyr Met Ile Asn Gly Met Pro Tyr Leu Gly Arg Gly Thr Gln Thr Asn 
305                 310                 315                 320 


Gly Val Pro Leu Gly Glu Tyr Tyr Val Lys Glu Leu Ser Lys Pro Val 
                325                 330                 335     


His Gly Ser Cys Arg Asn Ile Thr Cys Asp Asn Trp Phe Thr Ser Ile 
            340                 345                 350         


Pro Leu Ala Lys Asn Leu Leu Gln Glu Pro Tyr Lys Leu Thr Ile Val 
        355                 360                 365             


Gly Thr Val Arg Ser Asn Lys Arg Glu Ile Pro Glu Val Leu Lys Asn 
    370                 375                 380                 


Ser Arg Ser Arg Pro Val Gly Thr Ser Met Phe Cys Phe Asp Gly Pro 
385                 390                 395                 400 


Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ala Lys Met Val Tyr Leu 
                405                 410                 415     


Leu Ser Ser Cys Asp Glu Asp Ala Ser Ile Asn Glu Ser Thr Gly Lys 
            420                 425                 430         


Pro Gln Met Val Met Tyr Tyr Asn Gln Thr Lys Gly Gly Val Asp Thr 
        435                 440                 445             


Leu Asp Gln Met Cys Ser Val Met Thr Cys Ser Arg Lys Thr Asn Arg 
    450                 455                 460                 


Trp Pro Met Ala Leu Leu Tyr Gly Met Ile Asn Ile Ala Cys Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Ile Tyr Ser His Asn Val Ser Ser Lys Gly Glu Lys Val 
                485                 490                 495     


Gln Ser Arg Lys Lys Phe Met Arg Asn Leu Tyr Met Ser Leu Thr Ser 
            500                 505                 510         


Ser Phe Met Arg Lys Arg Leu Glu Ala Pro Thr Leu Lys Arg Tyr Leu 
        515                 520                 525             


Arg Asp Asn Ile Ser Asn Ile Leu Pro Lys Glu Val Pro Gly Thr Ser 
    530                 535                 540                 


Asp Asp Ser Thr Glu Glu Pro Val Met Lys Lys Arg Thr Tyr Cys Thr 
545                 550                 555                 560 


Tyr Cys Pro Ser Lys Ile Arg Arg Lys Ala Asn Ala Ser Cys Lys Lys 
                565                 570                 575     


Cys Lys Lys Val Ile Cys Arg Glu His Asn Ile Asp Met Cys Gln Ser 
            580                 585                 590         


Cys Phe 
        


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  4
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  5
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  5
atctacattt gggcaccact ggccgggacc tgtggagtgc tgctgctgag cctggtcatc       60

acactgtact gc                                                           72


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  7
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  7
cgcgtgaagt ttagtcgatc agcagatgcc ccagcttaca aacagggaca gaaccagctg       60

tataacgagc tgaatctggg ccgccgagag gaatatgacg tgctggataa gcggagagga      120

cgcgaccccg aaatgggagg caagcccagg cgcaaaaacc ctcaggaagg cctgtataac      180

gagctgcaga aggacaaaat ggcagaagcc tattctgaga tcggcatgaa gggggagcga      240

cggagaggca aagggcacga tgggctgtac cagggactga gcaccgccac aaaggacacc      300

tatgatgctc tgcatatgca ggcactgcct ccaagg                                336


<210>  8
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  9
aagagaggca ggaagaaact gctgtatatt ttcaaacagc ccttcatgcg ccccgtgcag       60

actacccagg aggaagacgg gtgctcctgt cgattccctg aggaagagga aggcgggtgt      120

gagctg                                                                 126


<210>  10
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  11
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  11
actaccacac cagcacctag accaccaact ccagctccaa ccatcgcgag tcagcccctg       60

agtctgagac ctgaggcctg caggccagct gcaggaggag ctgtgcacac caggggcctg      120

gacttcgcct gcgac                                                       135


<210>  12
<211>  594
<212>  PRT
<213>  Trichoplusia ni

<400>  12

Met Gly Ser Ser Leu Asp Asp Glu His Ile Leu Ser Ala Leu Leu Gln 
1               5                   10                  15      


Ser Asp Asp Glu Leu Val Gly Glu Asp Ser Asp Ser Glu Ile Ser Asp 
            20                  25                  30          


His Val Ser Glu Asp Asp Val Gln Ser Asp Thr Glu Glu Ala Phe Ile 
        35                  40                  45              


Asp Glu Val His Glu Val Gln Pro Thr Ser Ser Gly Ser Glu Ile Leu 
    50                  55                  60                  


Asp Glu Gln Asn Val Ile Glu Gln Pro Gly Ser Ser Leu Ala Ser Asn 
65                  70                  75                  80  


Arg Ile Leu Thr Leu Pro Gln Arg Thr Ile Arg Gly Lys Asn Lys His 
                85                  90                  95      


Cys Trp Ser Thr Ser Lys Ser Thr Arg Arg Ser Arg Val Ser Ala Leu 
            100                 105                 110         


Asn Ile Val Arg Ser Gln Arg Gly Pro Thr Arg Met Cys Arg Asn Ile 
        115                 120                 125             


Tyr Asp Pro Leu Leu Cys Phe Lys Leu Phe Phe Thr Asp Glu Ile Ile 
    130                 135                 140                 


Ser Glu Ile Val Lys Trp Thr Asn Ala Glu Ile Ser Leu Lys Arg Arg 
145                 150                 155                 160 


Glu Ser Met Thr Gly Ala Thr Phe Arg Asp Thr Asn Glu Asp Glu Ile 
                165                 170                 175     


Tyr Ala Phe Phe Gly Ile Leu Val Met Thr Ala Val Arg Lys Asp Asn 
            180                 185                 190         


His Met Ser Thr Asp Asp Leu Phe Asp Arg Ser Leu Ser Met Val Tyr 
        195                 200                 205             


Val Ser Val Met Ser Arg Asp Arg Phe Asp Phe Leu Ile Arg Cys Leu 
    210                 215                 220                 


Arg Met Asp Asp Lys Ser Ile Arg Pro Thr Leu Arg Glu Asn Asp Val 
225                 230                 235                 240 


Phe Thr Pro Val Arg Lys Ile Trp Asp Leu Phe Ile His Gln Cys Ile 
                245                 250                 255     


Gln Asn Tyr Thr Pro Gly Ala His Leu Thr Ile Asp Glu Gln Leu Leu 
            260                 265                 270         


Gly Phe Arg Gly Arg Cys Pro Phe Arg Met Tyr Ile Pro Asn Lys Pro 
        275                 280                 285             


Ser Lys Tyr Gly Ile Lys Ile Leu Met Met Cys Asp Ser Gly Tyr Lys 
    290                 295                 300                 


Tyr Met Ile Asn Gly Met Pro Tyr Leu Gly Arg Gly Thr Gln Thr Asn 
305                 310                 315                 320 


Gly Val Pro Leu Gly Glu Tyr Tyr Val Lys Glu Leu Ser Lys Pro Val 
                325                 330                 335     


His Gly Ser Cys Arg Asn Ile Thr Cys Asp Asn Trp Phe Thr Ser Ile 
            340                 345                 350         


Pro Leu Ala Lys Asn Leu Leu Gln Glu Pro Tyr Lys Leu Thr Ile Val 
        355                 360                 365             


Gly Thr Val Arg Ser Asn Lys Arg Glu Ile Pro Glu Val Leu Lys Asn 
    370                 375                 380                 


Ser Arg Ser Arg Pro Val Gly Thr Ser Met Phe Cys Phe Asp Gly Pro 
385                 390                 395                 400 


Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ala Lys Met Val Tyr Leu 
                405                 410                 415     


Leu Ser Ser Cys Asp Glu Asp Ala Ser Ile Asn Glu Ser Thr Gly Lys 
            420                 425                 430         


Pro Gln Met Val Met Tyr Tyr Asn Gln Thr Lys Gly Gly Val Asp Thr 
        435                 440                 445             


Leu Asp Gln Met Cys Ser Val Met Thr Cys Ser Arg Lys Thr Asn Arg 
    450                 455                 460                 


Trp Pro Met Ala Leu Leu Tyr Gly Met Ile Asn Ile Ala Cys Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Ile Tyr Ser His Asn Val Ser Ser Lys Gly Glu Lys Val 
                485                 490                 495     


Gln Ser Arg Lys Lys Phe Met Arg Asn Leu Tyr Met Ser Leu Thr Ser 
            500                 505                 510         


Ser Phe Met Arg Lys Arg Leu Glu Ala Pro Thr Leu Lys Arg Tyr Leu 
        515                 520                 525             


Arg Asp Asn Ile Ser Asn Ile Leu Pro Asn Glu Val Pro Gly Thr Ser 
    530                 535                 540                 


Asp Asp Ser Thr Glu Glu Pro Val Met Lys Lys Arg Thr Tyr Cys Thr 
545                 550                 555                 560 


Tyr Cys Pro Ser Lys Ile Arg Arg Lys Ala Asn Ala Ser Cys Lys Lys 
                565                 570                 575     


Cys Lys Lys Val Ile Cys Arg Glu His Asn Ile Asp Met Cys Gln Ser 
            580                 585                 590         


Cys Phe 
        


<210>  13
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  90  


<210>  14
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FN3 domain consensus sequence

<400>  14
atgctgcctg caccaaagaa cctggtggtg tctcatgtga cagaggatag tgccagactg       60

tcatggactg ctcccgacgc agccttcgat agttttatca tcgtgtaccg ggagaacatc      120

gaaaccggcg aggccattgt cctgacagtg ccagggtccg aacgctctta tgacctgaca      180

gatctgaagc ccggaactga gtactatgtg cagatcgccg gcgtcaaagg aggcaatatc      240

agcttccctc tgtccgcaat cttcaccaca                                       270


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 concensus sequence

<400>  15

Thr Glu Asp Ser 
1               


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 domain consensus

<400>  16

Thr Ala Pro Asp Ala Ala Phe 
1               5           


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 domain concensus

<400>  17

Ser Glu Lys Val Gly Glu 
1               5       


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 domain consensus

<400>  18

Gly Ser Glu Arg 
1               


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 domain consensus

<400>  19

Gly Leu Lys Pro Gly 
1               5   


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modification of FN3 domain consensus

<400>  20

Lys Gly Gly His Arg Ser Asn 
1               5           


<210>  21
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARTyrin

<400>  21

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
        115                 120                 125             


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
    130                 135                 140                 


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
145                 150                 155                 160 


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
                165                 170                 175     


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
            180                 185                 190         


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
        195                 200                 205             


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
    210                 215                 220                 


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
225                 230                 235                 240 


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
                245                 250                 255     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
            260                 265                 270         


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
        275                 280                 285             


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
    290                 295                 300                 


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
305                 310                 315                 320 


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
                325                 330                 335     


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
            340                 345                 350         


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
        355                 360                 365             


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
    370                 375                 380                 


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser Gly Ser Gly Glu Gly 
385                 390                 395                 400 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                405                 410                 415     


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
            420                 425                 430         


His Ala Ala Arg Pro Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
        435                 440                 445             


Arg Ile Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
    450                 455                 460                 


Ala Phe Asp Ser Phe Pro Ile Arg Tyr Ile Glu Thr Leu Ile Trp Gly 
465                 470                 475                 480 


Glu Ala Ile Trp Leu Asp Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
                485                 490                 495     


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Ala Val Val Ile Thr Gly Val 
            500                 505                 510         


Lys Gly Gly Arg Phe Ser Ser Pro Leu Val Ala Ser Phe Thr Thr Thr 
        515                 520                 525             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    530                 535                 540                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
545                 550                 555                 560 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                565                 570                 575     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            580                 585                 590         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        595                 600                 605             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    610                 615                 620                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
625                 630                 635                 640 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                645                 650                 655     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            660                 665                 670         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        675                 680                 685             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    690                 695                 700                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
705                 710                 715                 720 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                725                 730                 735     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            740                 745                 750         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        755                 760                 765             


Pro Gly Pro Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln 
    770                 775                 780                 


Asn Met Gly Ile Gly Lys Asn Gly Asp Phe Pro Trp Pro Pro Leu Arg 
785                 790                 795                 800 


Asn Glu Ser Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu 
                805                 810                 815     


Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile 
            820                 825                 830         


Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser 
        835                 840                 845             


Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser 
    850                 855                 860                 


Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys 
865                 870                 875                 880 


Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala 
                885                 890                 895     


Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln 
            900                 905                 910         


Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr 
        915                 920                 925             


Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu 
    930                 935                 940                 


Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
945                 950                 955             


<210>  22
<211>  2874
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CARTyrin

<400>  22
atgggggtcc aggtcgagac tatttcacca ggggatgggc gaacatttcc aaaaaggggc       60

cagacttgcg tcgtgcatta caccgggatg ctggaggacg ggaagaaagt ggacagctcc      120

agggatcgca acaagccctt caagttcatg ctgggaaagc aggaagtgat ccgaggatgg      180

gaggaaggcg tggcacagat gtcagtcggc cagcgggcca aactgaccat tagccctgac      240

tacgcttatg gagcaacagg ccacccaggg atcattcccc ctcatgccac cctggtcttc      300

gatgtggaac tgctgaagct ggagggagga ggaggatccg gatttgggga cgtgggggcc      360

ctggagtctc tgcgaggaaa tgccgatctg gcttacatcc tgagcatgga accctgcggc      420

cactgtctga tcattaacaa tgtgaacttc tgcagagaaa gcggactgcg aacacggact      480

ggctccaata ttgactgtga gaagctgcgg agaaggttct ctagtctgca ctttatggtc      540

gaagtgaaag gggatctgac cgccaagaaa atggtgctgg ccctgctgga gctggctcag      600

caggaccatg gagctctgga ttgctgcgtg gtcgtgatcc tgtcccacgg gtgccaggct      660

tctcatctgc agttccccgg agcagtgtac ggaacagacg gctgtcctgt cagcgtggag      720

aagatcgtca acatcttcaa cggcacttct tgccctagtc tggggggaaa gccaaaactg      780

ttctttatcc aggcctgtgg cggggaacag aaagatcacg gcttcgaggt ggccagcacc      840

agccctgagg acgaatcacc agggagcaac cctgaaccag atgcaactcc attccaggag      900

ggactgagga cctttgacca gctggatgct atctcaagcc tgcccactcc tagtgacatt      960

ttcgtgtctt acagtacctt cccaggcttt gtctcatggc gcgatcccaa gtcagggagc     1020

tggtacgtgg agacactgga cgacatcttt gaacagtggg cccattcaga ggacctgcag     1080

agcctgctgc tgcgagtggc aaacgctgtc tctgtgaagg gcatctacaa acagatgccc     1140

gggtgcttca attttctgag aaagaaactg ttctttaaga cttccggatc tggagaggga     1200

aggggaagcc tgctgacctg tggagacgtg gaggaaaacc caggaccaat ggcactgcca     1260

gtcaccgccc tgctgctgcc tctggctctg ctgctgcacg cagctagacc aatgctgcct     1320

gcaccaaaga acctggtggt gagccggatc acagaggact ccgccagact gtcttggacc     1380

gcccctgacg ccgccttcga ttcctttcca atccggtaca tcgagacact gatctggggc     1440

gaggccatct ggctggacgt gcccggctct gagaggagct acgatctgac aggcctgaag     1500

cctggcaccg agtatgcagt ggtcatcaca ggagtgaagg gcggcaggtt cagctcccct     1560

ctggtggcct cttttaccac aaccacaacc cctgccccca gacctcccac acccgcccct     1620

accatcgcga gtcagcccct gagtctgaga cctgaggcct gcaggccagc tgcaggagga     1680

gctgtgcaca ccaggggcct ggacttcgcc tgcgacatct acatttgggc accactggcc     1740

gggacctgtg gagtgctgct gctgagcctg gtcatcacac tgtactgcaa gagaggcagg     1800

aagaaactgc tgtatatttt caaacagccc ttcatgcgcc ccgtgcagac tacccaggag     1860

gaagacgggt gctcctgtcg attccctgag gaagaggaag gcgggtgtga gctgcgcgtg     1920

aagtttagtc gatcagcaga tgccccagct tacaaacagg gacagaacca gctgtataac     1980

gagctgaatc tgggccgccg agaggaatat gacgtgctgg ataagcggag aggacgcgac     2040

cccgaaatgg gaggcaagcc caggcgcaaa aaccctcagg aaggcctgta taacgagctg     2100

cagaaggaca aaatggcaga agcctattct gagatcggca tgaaggggga gcgacggaga     2160

ggcaaagggc acgatgggct gtaccaggga ctgagcaccg ccacaaagga cacctatgat     2220

gctctgcata tgcaggcact gcctccaagg ggaagtggag aaggacgagg atcactgctg     2280

acatgcggcg acgtggagga aaaccctggc ccaatggtcg ggtctctgaa ttgtatcgtc     2340

gccgtgagtc agaacatggg cattgggaag aatggcgatt tcccatggcc acctctgcgc     2400

aacgagtccc gatactttca gcggatgaca actacctcct ctgtggaagg gaaacagaat     2460

ctggtcatca tgggaaagaa aacttggttc agcattccag agaagaaccg gcccctgaaa     2520

ggcagaatca atctggtgct gtcccgagaa ctgaaggagc caccacaggg agctcacttt     2580

ctgagccggt ccctggacga tgcactgaag ctgacagaac agcctgagct ggccaacaaa     2640

gtcgatatgg tgtggatcgt cgggggaagt tcagtgtata aggaggccat gaatcacccc     2700

ggccatctga aactgttcgt cacacggatc atgcaggact ttgagagcga tactttcttt     2760

cctgaaattg acctggagaa gtacaaactg ctgcccgaat atcctggcgt gctgtccgat     2820

gtccaggaag agaaaggcat caaatacaag ttcgaggtct atgagaagaa tgac           2874


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 polypeptide

<400>  23

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FKBP12 polypeptide

<400>  24
ggggtccagg tcgagactat ttcaccaggg gatgggcgaa catttccaaa aaggggccag       60

acttgcgtcg tgcattacac cgggatgctg gaggacggga agaaagtgga cagctccagg      120

gatcgcaaca agcccttcaa gttcatgctg ggaaagcagg aagtgatccg aggatgggag      180

gaaggcgtgg cacagatgtc agtcggccag cgggccaaac tgaccattag ccctgactac      240

gcttatggag caacaggcca cccagggatc attccccctc atgccaccct ggtcttcgat      300

gtggaactgc tgaagctgga g                                                321


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  25

Gly Gly Gly Gly Ser 
1               5   


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  26
ggaggaggag gatcc                                                        15


<210>  27
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated caspase 9

<400>  27

Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp 
1               5                   10                  15      


Leu Ala Tyr Ile Ser Leu Met Glu Pro Cys Gly His Cys Leu Ile Ile 
            20                  25                  30          


Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly 
        35                  40                  45              


Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His 
    50                  55                  60                  


Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu 
65                  70                  75                  80  


Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys 
                85                  90                  95      


Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe 
            100                 105                 110         


Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys 
        115                 120                 125             


Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys 
    130                 135                 140                 


Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His 
145                 150                 155                 160 


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
                165                 170                 175     


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
            180                 185                 190         


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
        195                 200                 205             


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
    210                 215                 220                 


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
225                 230                 235                 240 


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
                245                 250                 255     


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Asn Phe Leu 
            260                 265                 270         


Arg Lys Lys Leu Phe Phe Lys Thr Ser 
        275                 280     


<210>  28
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated caspase 9

<400>  28
tttggggacg tgggggccct ggagtctctg cgaggaaatg ccgatctggc ttacatcctg       60

agcatggaac cctgcggcca ctgtctgatc attaacaatg tgaacttctg cagagaaagc      120

ggactgcgaa cacggactgg ctccaatatt gactgtgaga agctgcggag aaggttctct      180

agtctgcact ttatggtcga agtgaaaggg gatctgaccg ccaagaaaat ggtgctggcc      240

ctgctggagc tggctcagca ggaccatgga gctctggatt gctgcgtggt cgtgatcctg      300

tcccacgggt gccaggcttc tcatctgcag ttccccggag cagtgtacgg aacagacggc      360

tgtcctgtca gcgtggagaa gatcgtcaac atcttcaacg gcacttcttg ccctagtctg      420

gggggaaagc caaaactgtt ctttatccag gcctgtggcg gggaacagaa agatcacggc      480

ttcgaggtgg ccagcaccag ccctgaggac gaatcaccag ggagcaaccc tgaaccagat      540

gcaactccat tccaggaggg actgaggacc tttgaccagc tggatgctat ctcaagcctg      600

cccactccta gtgacatttt cgtgtcttac agtaccttcc caggctttgt ctcatggcgc      660

gatcccaagt cagggagctg gtacgtggag acactggacg acatctttga acagtgggcc      720

cattcagagg acctgcagag cctgctgctg cgagtggcaa acgctgtctc tgtgaagggc      780

atctacaaac agatgcccgg gtgcttcaat tttctgagaa agaaactgtt ctttaagact      840

tcc                                                                    843


<210>  29
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inducible proapoptotic polypeptide

<400>  29

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
        115                 120                 125             


Asp Leu Ala Tyr Ile Ser Leu Met Glu Pro Cys Gly His Cys Leu Ile 
    130                 135                 140                 


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
145                 150                 155                 160 


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
                165                 170                 175     


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
            180                 185                 190         


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
        195                 200                 205             


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
    210                 215                 220                 


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
225                 230                 235                 240 


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
                245                 250                 255     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
            260                 265                 270         


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
        275                 280                 285             


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
    290                 295                 300                 


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
305                 310                 315                 320 


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
                325                 330                 335     


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
            340                 345                 350         


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
        355                 360                 365             


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Asn Phe 
    370                 375                 380                 


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 


<210>  30
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inducible proapoptotic polypeptide

<400>  30
ggggtccagg tcgagactat ttcaccaggg gatgggcgaa catttccaaa aaggggccag       60

acttgcgtcg tgcattacac cgggatgctg gaggacggga agaaagtgga cagctccagg      120

gatcgcaaca agcccttcaa gttcatgctg ggaaagcagg aagtgatccg aggatgggag      180

gaaggcgtgg cacagatgtc agtcggccag cgggccaaac tgaccattag ccctgactac      240

gcttatggag caacaggcca cccagggatc attccccctc atgccaccct ggtcttcgat      300

gtggaactgc tgaagctgga gggaggagga ggatccgaat ttggggacgt gggggccctg      360

gagtctctgc gaggaaatgc cgatctggct tacatcctga gcatggaacc ctgcggccac      420

tgtctgatca ttaacaatgt gaacttctgc agagaaagcg gactgcgaac acggactggc      480

tccaatattg actgtgagaa gctgcggaga aggttctcta gtctgcactt tatggtcgaa      540

gtgaaagggg atctgaccgc caagaaaatg gtgctggccc tgctggagct ggctcagcag      600

gaccatggag ctctggattg ctgcgtggtc gtgatcctgt cccacgggtg ccaggcttct      660

catctgcagt tccccggagc agtgtacgga acagacggct gtcctgtcag cgtggagaag      720

atcgtcaaca tcttcaacgg cacttcttgc cctagtctgg ggggaaagcc aaaactgttc      780

tttatccagg cctgtggcgg ggaacagaaa gatcacggct tcgaggtggc cagcaccagc      840

cctgaggacg aatcaccagg gagcaaccct gaaccagatg caactccatt ccaggaggga      900

ctgaggacct ttgaccagct ggatgctatc tcaagcctgc ccactcctag tgacattttc      960

gtgtcttaca gtaccttccc aggctttgtc tcatggcgcg atcccaagtc agggagctgg     1020

tacgtggaga cactggacga catctttgaa cagtgggccc attcagagga cctgcagagc     1080

ctgctgctgc gagtggcaaa cgctgtctct gtgaagggca tctacaaaca gatgcccggg     1140

tgcttcaatt ttctgagaaa gaaactgttc tttaagactt cc                        1182


<210>  31
<211>  18
<212>  PRT
<213>  Thosea asigna virus

<400>  31

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  32
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-T2A

<400>  32

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  33
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSG-T2A

<400>  33
ggatctggag agggaagggg aagcctgctg acctgtggag acgtggagga aaacccagga       60

cca                                                                     63


<210>  34
<211>  19
<212>  PRT
<213>  Equine rhinitis A

<400>  34

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly 
            


<210>  35
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-G2A

<400>  35

Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  36
<211>  22
<212>  PRT
<213>  FMDV-O

<400>  36

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-F2A

<400>  37

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  38
<211>  19
<212>  PRT
<213>  Porcine Teschovirus

<400>  38

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  39
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-P2A

<400>  39

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  40
<211>  4897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB-EF1a vector

<400>  40
tgtacataga ttaaccctag aaagataatc atattgtgac gtacgttaaa gataatcatg       60

cgtaaaattg acgcatgtgt tttatcggtc tgtatatcga ggtttattta ttaatttgaa      120

tagatattaa gttttattat atttacactt acatactaat aataaattca acaaacaatt      180

tatttatgtt tatttattta ttaaaaaaaa acaaaaactc aaaatttctt ctataaagta      240

acaaaacttt tatcgaatac ctgcagcccg ggggatgcag agggacagcc cccccccaaa      300

gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg      360

ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc      420

gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag      480

cctgcagaca cctgggggga tacggggaaa agttgactgt gcctttcgat cgaaccatgg      540

acagttagct ttgcaaagat ggataaagtt ttaaacagag aggaatcttt gcagctaatg      600

gaccttctag gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg      660

cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta      720

gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc      780

cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa      840

cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt      900

tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctgcagt acgtgattct      960

tgatcccgag cttcgggttg gaagtgggtg ggagagttcg aggccttgcg cttaaggagc     1020

cccttcgcct cgtgcttgag ttgaggcctg gcctgggcgc tggggccgcc gcgtgcgaat     1080

ctggtggcac cttcgcgcct gtctcgctgc tttcgataag tctctagcca tttaaaattt     1140

ttgatgacct gctgcgacgc tttttttctg gcaagatagt cttgtaaatg cgggccaaga     1200

tctgcacact ggtatttcgg tttttggggc cgcgggcggc gacggggccc gtgcgtccca     1260

gcgcacatgt tcggcgaggc ggggcctgcg agcgcggcca ccgagaatcg gacgggggta     1320

gtctcaagct ggccggcctg ctctggtgcc tggcctcgcg ccgccgtgta tcgccccgcc     1380

ctgggcggca aggctggccc ggtcggcacc agttgcgtga gcggaaagat ggccgcttcc     1440

cggccctgct gcagggagct caaaatggag gacgcggcgc tcgggagagc gggcgggtga     1500

gtcacccaca caaaggaaaa gggcctttcc gtcctcagcc gtcgcttcat gtgactccac     1560

ggagtaccgg gcgccgtcca ggcacctcga ttagttctcg agcttttgga gtacgtcgtc     1620

tttaggttgg ggggaggggt tttatgcgat ggagtttccc cacactgagt gggtggagac     1680

tgaagttagg ccagcttggc acttgatgta attctccttg gaatttgccc tttttgagtt     1740

tggatcttgg ttcattctca agcctcagac agtggttcaa agtttttttc ttccatttca     1800

ggtgtcgtga gaattctaat acgactcact atagggtgtg ctgtctcatc attttggcaa     1860

agattggcca ccaagcttgt cctgcaggag ggtcgacgcc tctagacggg cggccgctcc     1920

ggatccacgg gtaccgatca catatgcctt taattaaaca ctagttctat agtgtcacct     1980

aaattccctt tagtgagggt taatggccgt aggccgccag aattgggtcc agacatgata     2040

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     2100

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     2160

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     2220

tcggactcta ggacctgcgc atgcgcttgg cgtaatcatg gtcatagctg tttcctgttt     2280

tccccgtatc cccccaggtg tctgcaggct caaagagcag cgagaagcgt tcagaggaaa     2340

gcgatcccgt gccaccttcc ccgtgcccgg gctgtccccg cacgctgccg gctcggggat     2400

gcggggggag cgccggaccg gagcggagcc ccgggcggct cgctgctgcc ccctagcggg     2460

ggagggacgt aattacatcc ctgggggctt tggggggggg ctgtccctct caccgcggtg     2520

gagctccagc ttttgttcga attggggccc cccctcgagg gtatcgatga tatctataac     2580

aagaaaatat atatataata agttatcacg taagtagaac atgaaataac aatataatta     2640

tcgtatgagt taaatcttaa aagtcacgta aaagataatc atgcgtcatt ttgactcacg     2700

cggtcgttat agttcaaaat cagtgacact taccgcattg acaagcacgc ctcacgggag     2760

ctccaagcgg cgactgagat gtcctaaatg cacagcgacg gattcgcgct atttagaaag     2820

agagagcaat atttcaagaa tgcatgcgtc aattttacgc agactatctt tctagggtta     2880

atctagctag ccttaagggc gcctattgcg ttgcgctcac tgcccgcttt ccagtcggga     2940

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     3000

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     3060

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     3120

gcaggaaaga acatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     3180

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     3240

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     3300

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta     3360

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     3420

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     3480

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     3540

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     3600

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     3660

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     3720

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     3780

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     3840

ccttttgctc acatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     3900

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag tcagaagaac     3960

tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc     4020

acgaggaagc ggtcagccca ttcgccgcca agctcttcag caatatcacg ggtagccaac     4080

gctatgtcct gatagcggtc cgccacaccc agccggccac agtcgatgaa tccagaaaag     4140

cggccatttt ccaccatgat attcggcaag caggcatcgc catgggtcac gacgagatcc     4200

tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt cggctggcgc gagcccctga     4260

tgctcttcgt ccagatcatc ctgatcgaca agaccggctt ccatccgagt acgtgctcgc     4320

tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc     4380

cgccgcattg catcagccat gatggatact ttctcggcag gagcaaggtg agatgacagg     4440

agatcctgcc ccggcacttc gcccaatagc agccagtccc ttcccgcttc agtgacaacg     4500

tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc acgatagccg cgctgcctcg     4560

tcttgcagtt cattcagggc accggacagg tcggtcttga caaaaagaac cgggcgcccc     4620

tgcgctgaca gccggaacac ggcggcatca gagcagccga ttgtctgttg tgcccagtca     4680

tagccgaata gcctctccac ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca     4740

atcataatat tattgaagca tttatcaggg ttcgtctcgt cccggtctcc tcccaatgca     4800

tgtcaatatt ggccattagc catattattc attggttata tagcataaat caatattggc     4860

tattggccat tgcatacgtt gtatctatat cataata                              4897


<210>  41
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Centyrin

<400>  41

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Ile Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Pro Ile Arg Tyr Ile Glu Thr Leu Ile Trp Gly Glu Ala Ile Trp Leu 
        35                  40                  45              


Asp Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Val Ile Thr Gly Val Lys Gly Gly Arg Phe 
65                  70                  75                  80  


Ser Ser Pro Leu Val Ala Ser Phe Thr Thr 
                85                  90  


<210>  42
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARTyrin

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
            20                  25                  30          


Arg Ile Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
        35                  40                  45              


Ala Phe Asp Ser Phe Pro Ile Arg Tyr Ile Glu Thr Leu Ile Trp Gly 
    50                  55                  60                  


Glu Ala Ile Trp Leu Asp Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
65                  70                  75                  80  


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Ala Val Val Ile Thr Gly Val 
                85                  90                  95      


Lys Gly Gly Arg Phe Ser Ser Pro Leu Val Ala Ser Phe Thr Thr Thr 
            100                 105                 110         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        115                 120                 125             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    130                 135                 140                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
145                 150                 155                 160 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                165                 170                 175     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            180                 185                 190         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        195                 200                 205             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    210                 215                 220                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
225                 230                 235                 240 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                245                 250                 255     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            260                 265                 270         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        275                 280                 285             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    290                 295                 300                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
305                 310                 315                 320 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330                 


<210>  43
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Centyrin

<400>  43

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Ile Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Pro Ile Arg Tyr Ile Glu Thr Leu Ile Trp Gly Glu Ala Ile Trp Leu 
        35                  40                  45              


Asp Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Val Ile Thr Gly Val Lys Gly Gly Arg Phe 
65                  70                  75                  80  


Ser Ser Pro Leu Val Ala Ser Phe Thr Thr 
                85                  90  


<210>  44
<211>  1002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CARTyrin

<400>  44
atggcactgc cagtcaccgc cctgctgctg cctctggctc tgctgctgca cgcagctaga       60

ccaatgctgc ctgcaccaaa gaacctggtg gtgagccgga tcacagagga ctccgccaga      120

ctgtcttgga ccgcccctga cgccgccttc gattcctttc caatccggta catcgagaca      180

ctgatctggg gcgaggccat ctggctggac gtgcccggct ctgagaggag ctacgatctg      240

acaggcctga agcctggcac cgagtatgca gtggtcatca caggagtgaa gggcggcagg      300

ttcagctccc ctctggtggc ctcttttacc acaaccacaa cccctgcccc cagacctccc      360

acacccgccc ctaccatcgc gagtcagccc ctgagtctga gacctgaggc ctgcaggcca      420

gctgcaggag gagctgtgca caccaggggc ctggacttcg cctgcgacat ctacatttgg      480

gcaccactgg ccgggacctg tggagtgctg ctgctgagcc tggtcatcac actgtactgc      540

aagagaggca ggaagaaact gctgtatatt ttcaaacagc ccttcatgcg ccccgtgcag      600

actacccagg aggaagacgg gtgctcctgt cgattccctg aggaagagga aggcgggtgt      660

gagctgcgcg tgaagtttag tcgatcagca gatgccccag cttacaaaca gggacagaac      720

cagctgtata acgagctgaa tctgggccgc cgagaggaat atgacgtgct ggataagcgg      780

agaggacgcg accccgaaat gggaggcaag cccaggcgca aaaaccctca ggaaggcctg      840

tataacgagc tgcagaagga caaaatggca gaagcctatt ctgagatcgg catgaagggg      900

gagcgacgga gaggcaaagg gcacgatggg ctgtaccagg gactgagcac cgccacaaag      960

gacacctatg atgctctgca tatgcaggca ctgcctccaa gg                        1002


<210>  45
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  45
atggcactgc cagtcaccgc cctgctgctg cctctggctc tgctgctgca cgcagctaga       60

cca                                                                     63


