                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  MULTIPLE BI-SPECIFIC BINDING DOMAIN CONSTRUCTS WITH DIFFERENT 
       EPITOPE BINDING TO TREAT CANCER

<130>  F053-0052PCT

<150>  US 62/362,397
<151>  2016-07-14

<150>  US 62/480,230
<151>  2017-03-31

<160>  277   

<170>  PatentIn version 3.5

<210>  1
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Ser Ser Asn Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys 
1               5                   10                  15      


Ala Phe Leu Asp Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr 
            20                  25                  30          


Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln 
        35                  40                  45              


Leu Ala Lys Gln Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser 
    50                  55                  60                  


Val Glu Leu Ala His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr 
65                  70                  75                  80  


His Pro Asn Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe 
                85                  90                  95      


Asn Thr Ser Leu Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser 
            100                 105                 110         


Asp Ile Val Pro Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu 
        115                 120                 125             


Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys 
    130                 135                 140                 


Leu Glu Arg Asp Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala 
145                 150                 155                 160 


Arg Tyr Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu 
                165                 170                 175     


Ala Gly Ala Lys Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe 
            180                 185                 190         


Ala Pro Gly Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly 
        195                 200                 205             


Gly Val Gln Arg Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro 
    210                 215                 220                 


Leu Thr Pro Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile 
225                 230                 235                 240 


Ala Glu Ala Val Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr 
                245                 250                 255     


Tyr Asp Ala Gln Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro 
            260                 265                 270         


Asp Ser Ser Trp Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro 
        275                 280                 285             


Gly Phe Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His 
    290                 295                 300                 


Ser Thr Asn Glu Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg 
305                 310                 315                 320 


Gly Ala Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp 
                325                 330                 335     


Ser Trp Val Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val 
            340                 345                 350         


His Glu Ile Val Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg 
        355                 360                 365             


Pro Arg Arg Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly 
    370                 375                 380                 


Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln 
385                 390                 395                 400 


Glu Arg Gly Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn 
                405                 410                 415     


Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His 
            420                 425                 430         


Asn Leu Thr Lys Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys 
        435                 440                 445             


Ser Leu Tyr Glu Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser 
    450                 455                 460                 


Gly Met Pro Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val 
465                 470                 475                 480 


Phe Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys 
                485                 490                 495     


Asn Trp Glu Thr Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val 
            500                 505                 510         


Tyr Glu Thr Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys 
        515                 520                 525             


Tyr His Leu Thr Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu 
    530                 535                 540                 


Ala Asn Ser Ile Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val 
545                 550                 555                 560 


Leu Arg Lys Tyr Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro 
                565                 570                 575     


Gln Glu Met Lys Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala 
            580                 585                 590         


Val Lys Asn Phe Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln 
        595                 600                 605             


Asp Phe Asp Lys Ser Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln 
    610                 615                 620                 


Leu Met Phe Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp 
625                 630                 635                 640 


Arg Pro Phe Tyr Arg His Val Ile Tyr Ala Pro Ser Ser His Asn Lys 
                645                 650                 655     


Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile 
            660                 665                 670         


Glu Ser Lys Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln 
        675                 680                 685             


Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser 
    690                 695                 700                 


Glu Val Ala 
705         


<210>  2
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Ala Val Leu Leu Ala Leu Leu Met Ala Gly Leu Ala Leu Gln 
1               5                   10                  15      


Pro Gly Thr Ala Leu Leu Cys Tyr Ser Cys Lys Ala Gln Val Ser Asn 
            20                  25                  30          


Glu Asp Cys Leu Gln Val Glu Asn Cys Thr Gln Leu Gly Glu Gln Cys 
        35                  40                  45              


Trp Thr Ala Arg Ile Arg Ala Val Gly Leu Leu Thr Val Ile Ser Lys 
    50                  55                  60                  


Gly Cys Ser Leu Asn Cys Val Asp Asp Ser Gln Asp Tyr Tyr Val Gly 
65                  70                  75                  80  


Lys Lys Asn Ile Thr Cys Cys Asp Thr Asp Leu Cys Asn Ala Ser Gly 
                85                  90                  95      


Ala His Ala Leu Gln Pro Ala Ala Ala Ile Leu Ala Leu Leu Pro Ala 
            100                 105                 110         


Leu Gly Leu Leu Leu Trp Gly Pro Gly Gln Leu 
        115                 120             


<210>  3
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr His Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Val Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  4
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  5
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  6
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  7
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  8
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Val Arg 
305                 310 


<210>  9
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  10
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Glu Gly Arg His Met Arg Arg Val Pro Gly Val Ala Pro Thr Leu 
1               5                   10                  15      


Val Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala 
            20                  25                  30          


Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met 
        35                  40                  45              


His Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys 
    50                  55                  60                  


Asp Cys Glu Arg Arg Phe Phe Arg Ser Asp Gln Leu Lys Arg His Gln 
65                  70                  75                  80  


Arg Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg 
                85                  90                  95      


Lys Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr 
            100                 105                 110         


Gly Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe 
        115                 120                 125             


Ala Arg Ser Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn 
    130                 135                 140                 


Met Thr Lys Leu Gln Leu Ala Leu 
145                 150         


<210>  11
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 CDR

<400>  12

Ala Ser Gly Phe Asp Phe Ser Ala Tyr Tyr Met 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 CDR

<400>  13

Thr Ile Tyr Pro Ser Ser Gly 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 CDR

<400>  14

Ala Asp Arg Ala Thr Tyr Phe Cys Ala 
1               5                   


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 CDR

<400>  15

Asp Thr Ile Asp Trp Tyr 
1               5       


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 CDR

<400>  16

Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg 
1               5                   10                  15      


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  17

Tyr Ile Gly Gly Tyr Val Phe Gly 
1               5               


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  18

Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  19

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  20

Leu Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser 
1               5                   10          


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  21

Asp Tyr Pro Ile Ser 
1               5   


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  22

Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11 CDR

<400>  23

Gly Tyr Ser Thr Tyr Tyr Cys Asp Phe Asn Ile 
1               5                   10      


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  24

Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
1               5                   10          


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  25

Gly Ser Tyr Thr Lys Arg Pro 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  26

Gly Ala Asp Tyr Ile Gly Gly Tyr Val 
1               5                   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  27

Ala Tyr Tyr Met Ser 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  28

Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R12 CDR

<400>  29

Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile 
1               5                   10          


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  30

Lys Ala Ser Gln Asn Val Asp Ala Ala Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  31

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  32

Gln Gln Tyr Asp Ile Tyr Pro Tyr Thr 
1               5                   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  33

Asp Tyr Glu Met His 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  34

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A2 CDR

<400>  35

Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  36

Gln Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  37

Tyr Ala Ser Asn Leu Ala Ser 
1               5           


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  38

Leu Gly Ser Leu Ser Asn Ser Asp Asn Val 
1               5                   10  


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  39

Ser His Trp Met Ser 
1               5   


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  40

Ile Ile Ala Ala Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y31 CDR

<400>  41

Asp Tyr Gly Asp Tyr Arg Leu Val Thr Phe Asn Ile 
1               5                   10          


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  42

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  43

Ser Arg Leu His Ser Gly Val 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  44

Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
1               5                   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  45

Asp Tyr Gly Val Ser 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  46

Val Thr Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 CDR

<400>  47

Tyr Ala Met Asp Tyr Trp Gly 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  48

Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  49

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  50

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  51

Ser Tyr Asn Met His 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  52

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B8 CDR

<400>  53

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  54

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
1               5                   10          


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  55

Tyr Ser Ala Ser Phe Leu Glu Ser 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  56

Gln Gln His Tyr Thr Thr Pro Thr 
1               5               


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  57

Ser Gly Phe Asn Thr Lys Asp Thr Tyr Ile His Trp 
1               5                   10          


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  58

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR

<400>  59

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val 
1               5                   10      


<210>  60
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  60

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  61
<211>  471
<212>  PRT
<213>  Mus musculus

<400>  61

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Gly Gln Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        355                 360                 365             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    370                 375                 380                 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
385                 390                 395                 400 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                405                 410                 415     


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        435                 440                 445             


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    450                 455                 460                 


Phe Ser Arg Thr Pro Gly Lys 
465                 470     


<210>  62
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  62

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  63
<211>  469
<212>  PRT
<213>  Mus musculus

<400>  63

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Phe Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg 
    50                  55                  60                  


Leu Glu Trp Val Ala Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr 
65                  70                  75                  80  


Pro Asp Thr Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Ser Arg Leu Met Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  64
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  64

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  65
<211>  473
<212>  PRT
<213>  Mus musculus

<400>  65

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Thr Tyr Trp Met His Trp Ile Lys Gln Ser Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala 
            180                 185                 190         


Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu 
    370                 375                 380                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
385                 390                 395                 400 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                405                 410                 415     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            420                 425                 430         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        435                 440                 445             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    450                 455                 460                 


Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470             


<210>  66
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  66

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu His Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Val Gln Gly Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  67
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  67

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Val Ile His Pro Gly Asn Asn Ser Thr Ser Tyr 
65                  70                  75                  80  


Asn Ala Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Tyr Gly Tyr Asp Glu Arg Asn Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn 
                405                 410                 415     


Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  68
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  68

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Asn Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  69
<211>  461
<212>  PRT
<213>  Mus musculus

<400>  69

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Phe Gln Gln Ser Glu Thr Val Leu Ala 
            20                  25                  30          


Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala 
                85                  90                  95      


Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  70
<211>  227
<212>  PRT
<213>  Mus musculus

<400>  70

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser His Gly 
        35                  40                  45              


Val Glu Tyr Ala Gly Ala His Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gly Ser 
65                  70                  75                  80  


Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ser 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Arg Thr Phe Gly 
            100                 105                 110         


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
        115                 120                 125             


Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser 
    130                 135                 140                 


Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys 
145                 150                 155                 160 


Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp 
                165                 170                 175     


Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu 
            180                 185                 190         


Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu 
        195                 200                 205             


Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg 
    210                 215                 220                 


Asn Glu Cys 
225         


<210>  71
<211>  460
<212>  PRT
<213>  Mus musculus

<400>  71

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Thr Leu His Trp Leu Lys Gln Arg Ser Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr 
65                  70                  75                  80  


Asn Glu Arg Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Val Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg His Lys Phe Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  72
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  72

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  73
<211>  467
<212>  PRT
<213>  Mus musculus

<400>  73

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  74
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  74

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser 
            100                 105                 110         


Thr Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  75
<211>  462
<212>  PRT
<213>  Mus musculus

<400>  75

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ser Gly Arg Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr 
65                  70                  75                  80  


Glu Tyr Lys Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr 
                85                  90                  95      


Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Ile Tyr Tyr Cys Thr Arg Asp Thr Gly Pro Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  76

Arg Ala Ser Glu Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  77

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  78

Gln Gln Ser Lys Glu Val Pro Trp 
1               5               


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  79

Asp Tyr Asn Met His 
1               5   


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  80

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M195 CDR

<400>  81

Gly Arg Pro Ala Met Asp Tyr 
1               5           


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  82

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
1               5                   10  


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  83

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  84

Gln Gln Arg Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  85

Asp Tyr Gly Phe Ser 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  86

Trp Ile Thr Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 CDR

<400>  87

Asp Tyr Phe Tyr Gly Met Asp Tyr 
1               5               


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  88

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
1               5                   10                  15  


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  89

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  90

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  91

Asn Tyr Gly Met Asn 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  92

Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32716 CDR

<400>  93

Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
1               5                   


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  94

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  95

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  96

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  97

Asn Tyr Trp Met Asn 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  98

Arg Ile Asp Pro Ser Asp Ser Glu Ser His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDR

<400>  99

Tyr Asp Tyr Asp Asp Thr Met Asp Tyr 
1               5                   


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  100

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  101

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  102

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  103

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  104
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  104

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 CDR

<400>  105

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  106
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv from OKT3

<400>  106

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G6-F3 CDR

<400>  107

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  108

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G6-F3 CDR

<400>  109

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G6-F3 CDR

<400>  110

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G6-F3 CDR

<400>  111

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  112
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G6-F3 CDR

<400>  112

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B4-D7 CDR

<400>  113

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  114

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B4-D7 CDR

<400>  115

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B4-D7 CDR

<400>  116

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B4-D7 CDR

<400>  117

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B4-D7 CDR

<400>  118

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E7-C9 CDR

<400>  119

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  120

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E7-C9 CDR

<400>  121

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E7-C9 CDR

<400>  122

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E7-C9 CDR

<400>  123

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  124
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E7-C9 CDR

<400>  124

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F-H10 CDR

<400>  125

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  126

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F-H10 CDR

<400>  127

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F-H10 CDR

<400>  128

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F-H10 CDR

<400>  129

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F-H10 CDR

<400>  130

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  131

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  132

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  133

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  134

Ser Tyr Tyr Ile His 
1               5   


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  135

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 CDR

<400>  136

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  137
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  138
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  139

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  140

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  141

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  142

Asp Tyr Tyr Met His 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  143

Trp Ile Asp Pro Glu Asn Gly Asn Thr Leu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD80/CD86 CDR

<400>  144

Glu Gly Leu Phe Phe Ala Tyr 
1               5           


<210>  145
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  146
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB 1 CDR

<400>  147

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB 1 CDR

<400>  148

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB 1 CDR

<400>  149

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  150
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB 1 CDR

<400>  150

Tyr Tyr Trp Ser 
1               


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  151

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  152
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB 1 CDR

<400>  152

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  153
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  154

Arg Ala Ser Gln Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  155

Phe Gly Ser Asn Leu Glu Ser 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  156

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  157

Ser Ser Trp Ile His 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  158

Tyr Ile Tyr Pro Ser Thr Gly Phe Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  159
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 1 CDR

<400>  159

Trp Arg Asp Ser Ser Gly Tyr His Ala Met Asp Tyr 
1               5                   10          


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  160

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  161

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  162

Gln Gln Ser Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  163

Asn Ser Gly Met His 
1               5   


<210>  164
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  164

Val Leu Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  165
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-1 2 CDR

<400>  165

Asn Asp Asp Tyr 
1               


<210>  166
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  167

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  168

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  169

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  170

Asp Tyr Tyr Trp Asn 
1               5   


<210>  171
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  171

Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  172
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LAG3 CDR

<400>  172

Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro 
1               5                   10          


<210>  173
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TIM-3 CDR

<400>  174

Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10      


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  175

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TIM-3 CDR

<400>  176

Ser Arg Lys Asp Pro Ser 
1               5       


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TIM-3 CDR

<400>  177

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TIM-3 CDR

<400>  178

Tyr Pro Gly Asn Gly Asp 
1               5       


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-TIM-3 CDR

<400>  179

Val Gly Gly Ala Phe Pro Met Asp Tyr 
1               5                   


<210>  180
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  181
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  181

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  182

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  183

Gln Gln Tyr Gly Ser Ser Ile Thr 
1               5               


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  184

Thr Ile Gly Val Gly Val Asn 
1               5           


<210>  185
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  185

Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Arg 
1               5                   10                  15      


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 1 CDR

<400>  186

Ser Gly Ile Thr Glu Val Arg Gly Val Ile Ile His Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  187
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  187

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  188

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  189
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  189

Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210>  190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  190

Thr Ser Gly Met Cys Val Ser 
1               5           


<210>  191
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  191

Leu Ile Asp Trp Asp Asp Val Lys Tyr Tyr Ser Ser Ser Leu Lys Thr 
1               5                   10                  15      


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-BTLA 2 CDR

<400>  192

Ile Arg Phe Thr Met Phe Arg Gly Val Tyr Tyr Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210>  193
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  194
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  194

Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  195

Gly Ala Phe Ser Arg Ala Thr 
1               5           


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  196

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  197

Ser Tyr Thr Met His 
1               5   


<210>  198
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  198

Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 1 CDR

<400>  199

Thr Gly Trp Leu Gly Pro Phe Asp Tyr 
1               5                   


<210>  200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  200

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  201

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  202

Gln Gln Tyr Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  203

Ser Tyr Gly Met His 
1               5   


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  204

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 2 CDR

<400>  205

Ala Pro Asn Tyr Ile Gly Ala Phe Asp Val 
1               5                   10  


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  206

Ser Ala Thr Ser Ser Ile Thr Tyr Met Ser 
1               5                   10  


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  207

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  208

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  209
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  209

Ser Tyr Gly Val Tyr 
1               5   


<210>  210
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  210

Val Ile Trp Ala Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  211
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CTLA-4 3 CDR

<400>  211

Gly Pro Pro His Ala Met Met Lys Arg Gly Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  212
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 
            260                 265                 270         


Gly Val Gln Lys Met Thr 
        275             


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  213

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  214

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  215

Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  216

Gly Phe Thr Phe Ser Gly Phe Ala Met Ser 
1               5                   10  


<210>  217
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  217

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Leu Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD200 CDR

<400>  218

Gly Asn Tyr Tyr Ser Gly Thr Ser Tyr Asp Tyr 
1               5                   10      


<210>  219
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VISTA CDR

<400>  220

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VISTA CDR

<400>  221

Ile Ile Pro Ile Phe Gly Thr 
1               5           


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VISTA CDR

<400>  222

Ala Arg Ser Ser Tyr Gly Trp 
1               5           


<210>  223
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VISTA CDR

<400>  223

Gln Ser Ile Asp Thr Arg 
1               5       


<210>  224
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  224

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-VISTA CDR

<400>  225

Gln Gln Ser Ala Tyr Asn Pro 
1               5           


<210>  226
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  226

Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala 
1               5                   10      


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  227

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  228

Gln Gln His Asn Glu Asn Pro Leu Thr 
1               5                   


<210>  229
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  229

Gly Phe Asn Ile Lys Asp 
1               5       


<210>  230
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  230

Arg Ile Asp Pro Ala Asn Asp Asn Thr 
1               5                   


<210>  231
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OKT8 CDR

<400>  231

Gly Tyr Gly Tyr Tyr Val Phe Asp His 
1               5                   


<210>  232
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-KIR2DL1 light chain

<400>  232

Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  233
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-KIR2DL1 heavy chain

<400>  233

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  234
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  235
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  236
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His 
    210                 215                 220                 


Val Phe Ile Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val 
225                 230                 235                 240 


Ile Ile Gln Arg Lys Arg Ile 
                245         


<210>  237
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  238
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  238

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ile 
            20                  25                  30          


Met Ser Thr Thr Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asn Val Asp Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
            100                 105                 110         


Tyr Asp Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
                165                 170                 175     


Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg 
            340                 345                 350         


Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr 
        355                 360                 365             


Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                405                 410                 415     


Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr 
            420                 425                 430         


Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        435                 440                 445             


Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
465                 470                 475                 480 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr 
                485                 490                 495     


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gln Lys 
            500                 505                 510         


Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        515                 520                 525 


<210>  239
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  239

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Gln Lys Ile 
            20                  25                  30          


Met Ser Thr Thr Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asn Val Asp Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
            100                 105                 110         


Tyr Asp Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
                165                 170                 175     


Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gln Val Gln Leu Leu 
            260                 265                 270         


Glu Ser Gly Pro Glu Leu Leu Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Tyr Pro 
305                 310                 315                 320 


Tyr Thr Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Asn Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Ser Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Asn Phe Arg 
        355                 360                 365             


Tyr Thr Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                405                 410                 415     


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            420                 425                 430         


Ser Tyr Asp Asn Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Pro Pro Lys Val Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
465                 470                 475                 480 


Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                485                 490                 495     


Asn Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            500                 505                 510         


Lys Arg His His His His His His 
        515                 520 


<210>  240
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  240

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Leu Val Met Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Thr Ser Gly Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Pro Pro Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly 
            100                 105                 110         


Gly Val Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro 
145                 150                 155                 160 


Ala Gly Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn 
                165                 170                 175     


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu 
    210                 215                 220                 


Lys Met Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly 
                245                 250                 255     


Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu 
            260                 265                 270         


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
305                 310                 315                 320 


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
                325                 330                 335     


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
        355                 360                 365             


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
    370                 375                 380                 


Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
        435                 440                 445             


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                485                 490                 495     


Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu 
            500                 505                 510         


Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        515                 520                 525         


<210>  241
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  241

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser 
            20                  25                  30          


Gly Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val 
        115                 120                 125             


Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly 
145                 150                 155                 160 


Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr 
                165                 170                 175     


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
    210                 215                 220                 


Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
225                 230                 235                 240 


Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu 
                245                 250                 255     


Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln 
            260                 265                 270         


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
        275                 280                 285             


Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
    290                 295                 300                 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
305                 310                 315                 320 


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
                325                 330                 335     


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            340                 345                 350         


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
        355                 360                 365             


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    370                 375                 380                 


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
        435                 440                 445             


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
                485                 490                 495     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His His His 
            500                 505                 510         


His His His 
        515 


<210>  242
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  242

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Met Thr Gln Thr Pro Ser Ser Thr Ser 
            20                  25                  30          


Gly Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Glu Val Val 
        115                 120                 125             


Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly 
145                 150                 155                 160 


Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr 
                165                 170                 175     


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
    210                 215                 220                 


Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
225                 230                 235                 240 


Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu 
                245                 250                 255     


Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
            260                 265                 270         


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
        275                 280                 285             


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly 
305                 310                 315                 320 


Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu 
                325                 330                 335     


Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu 
            340                 345                 350         


Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly 
        355                 360                 365             


Leu Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                405                 410                 415     


Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val 
            420                 425                 430         


Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        435                 440                 445             


Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro 
                485                 490                 495     


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys His His His His 
            500                 505                 510         


His His 
        


<210>  243
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  243

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala 
            20                  25                  30          


Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His 
        35                  40                  45              


Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro 
    50                  55                  60                  


Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr 
                85                  90                  95      


Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Thr Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala 
        195                 200                 205             


Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn 
    210                 215                 220                 


Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn 
                245                 250                 255     


Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly 
        275                 280                 285             


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg 
    290                 295                 300                 


Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
305                 310                 315                 320 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys 
                325                 330                 335     


Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
            340                 345                 350         


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln 
                405                 410                 415     


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
            420                 425                 430         


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
        435                 440                 445             


Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
    450                 455                 460                 


Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
465                 470                 475                 480 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            500                 505                 510         


Leu Glu Leu Lys His His His His His His 
        515                 520         


<210>  244
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  244

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala 
            20                  25                  30          


Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His 
        35                  40                  45              


Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro 
    50                  55                  60                  


Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr 
                85                  90                  95      


Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Thr Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala 
        195                 200                 205             


Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn 
    210                 215                 220                 


Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn 
                245                 250                 255     


Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
        275                 280                 285             


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
    290                 295                 300                 


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
305                 310                 315                 320 


Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
                325                 330                 335     


Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala 
            340                 345                 350         


Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe 
        355                 360                 365             


Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly 
    370                 375                 380                 


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                405                 410                 415     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His 
            420                 425                 430         


Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr 
    450                 455                 460                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
465                 470                 475                 480 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys His His His His His His 
        515                 520     


<210>  245
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  245

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser 
            20                  25                  30          


Thr Thr Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Asp Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr Glu Met 
                165                 170                 175     


His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ala 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Gly 
225                 230                 235                 240 


Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
            260                 265                 270         


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        275                 280                 285             


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
    290                 295                 300                 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
305                 310                 315                 320 


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
                325                 330                 335     


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
            340                 345                 350         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
        355                 360                 365             


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    370                 375                 380                 


Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
                405                 410                 415     


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            420                 425                 430         


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
        435                 440                 445             


Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
465                 470                 475                 480 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                485                 490                 495     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His His His His 
            500                 505                 510         


His His 
        


<210>  246
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  246

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu 
            100                 105                 110         


Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp 
            180                 185                 190         


Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
            260                 265                 270         


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
        275                 280                 285             


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn 
305                 310                 315                 320 


Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr 
                325                 330                 335     


Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
            340                 345                 350         


Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu 
        355                 360                 365             


Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                405                 410                 415     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            420                 425                 430         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        435                 440                 445             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
465                 470                 475                 480 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                485                 490                 495     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys His His His His His 
            500                 505                 510         


His 
    


<210>  247
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  247

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Cys 
            180                 185                 190         


Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys Asp 
        195                 200                 205             


Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg 
225                 230                 235                 240 


Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser His His His His His His 
            260                 265             


<210>  248
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  248

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu 
            100                 105                 110         


Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp 
            180                 185                 190         


Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser His His His His His His 
            260                 265     


<210>  249
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  249

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser 
65                  70                  75                  80  


Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys 
            100                 105                 110         


Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
145                 150                 155                 160 


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
                165                 170                 175     


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Phe Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            340                 345                 350         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu 
                405                 410                 415     


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
            420                 425                 430         


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
        435                 440                 445             


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
    450                 455                 460                 


Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
                485                 490                 495     


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly 
            500                 505                 510         


Thr Lys Leu Glu Leu Lys His His His His His His 
        515                 520                 


<210>  250
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  250

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
65                  70                  75                  80  


Ala Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn 
            180                 185                 190         


Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser 
225                 230                 235                 240 


Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His 
                245                 250                 255     


Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    290                 295                 300                 


Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
            340                 345                 350         


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
    370                 375                 380                 


Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
            420                 425                 430         


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
        435                 440                 445             


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
    450                 455                 460                 


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                485                 490                 495     


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
            500                 505                 510         


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu His His His 
        515                 520                 525             


His His His 
    530     


<210>  251
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  251

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser 
65                  70                  75                  80  


Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys 
            100                 105                 110         


Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
145                 150                 155                 160 


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
                165                 170                 175     


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Phe Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn 
                325                 330                 335     


Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
                405                 410                 415     


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
            420                 425                 430         


Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu 
    450                 455                 460                 


His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
465                 470                 475                 480 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Val Glu Ile Lys His His His His His His 
        515                 520             


<210>  252
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BS-BDC

<400>  252

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala 
            20                  25                  30          


Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His 
        35                  40                  45              


Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro 
    50                  55                  60                  


Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr 
                85                  90                  95      


Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Thr Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala 
        195                 200                 205             


Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn 
    210                 215                 220                 


Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn 
                245                 250                 255     


Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
        275                 280                 285             


Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr 
    290                 295                 300                 


Tyr Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
305                 310                 315                 320 


Met Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
                325                 330                 335     


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
            340                 345                 350         


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr 
        355                 360                 365             


Cys Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val 
                405                 410                 415     


Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly 
            420                 425                 430         


Asp Gln Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val 
        435                 440                 445             


Leu Val Ile Tyr Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg 
    450                 455                 460                 


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
465                 470                 475                 480 


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly 
                485                 490                 495     


Phe Gly Ser Leu Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


His His His His His His 
        515             


<210>  253
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  253

Arg Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn 
1               5                   10      


<210>  254
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  254

Tyr Ser Ser Arg Leu His Ser Gly 
1               5               


<210>  255
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  255

Gln Gln Asp Asp Ala Leu Pro Tyr Thr 
1               5                   


<210>  256
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  256

Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  257
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  257

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
1               5                   10              


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 CDR

<400>  258

Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5               


<210>  259
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  259

Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10      


<210>  260
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  260

His His His His His His 
1               5       


<210>  261
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  261

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  262
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  262

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  263
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  263

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  264

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  265
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  265

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDR

<400>  266

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  267
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  267

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  268
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  268

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  269
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  269

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  270
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  270

Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10      


<210>  271
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  271

Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  272
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 1 CDR

<400>  272

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  273
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 2 CDR

<400>  273

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  274
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 2 CDR

<400>  274

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  275
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 2 CDR

<400>  275

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  276
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 2 CDR

<400>  276

Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
1               5                   10      


<210>  277
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 2 CDR

<400>  277

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


