                               SEQUENCE LISTING

<110> SCHOLAR ROCK, INC.
	CARVEN, GREGORY J.
      SCHURPF, THOMAS
      TURNER, KATHERINE
 
<120> TGF-BETA ANTIBODIES, METHODS, AND USES

<130> JBI5093WOPCT

<140> TO BE ASSIGNED
<141> 2017-07-14

<150> 62/371,355
<151> 2016-08-05

<150> 62/362,393
<151> 2016-07-14

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 614
<212> PRT
<213> Homo sapiens

<400> 1
His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys Val Ser Cys 
1               5                   10                  15      


Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro Pro Asp Thr 
            20                  25                  30          


Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile Leu Ala Ser 
        35                  40                  45              


Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu Ser Thr Asn 
    50                  55                  60                  


Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu Thr His Leu 
65                  70                  75                  80  


Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala Thr Ala Leu 
                85                  90                  95      


Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser Leu Asp Leu 
            100                 105                 110         


Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu Leu Gly Glu 
        115                 120                 125             


Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser Leu Thr Arg 
    130                 135                 140                 


Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu Gln Leu Asp 
145                 150                 155                 160 


Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala Phe Glu Gly 
                165                 170                 175     


Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser Leu Thr Cys 
            180                 185                 190         


Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp Leu Ser Cys 
        195                 200                 205             


Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln Ala Glu Phe 
    210                 215                 220                 


Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu His Phe Pro 
225                 230                 235                 240 


Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu Ser Asn Asn 
                245                 250                 255     


Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys Gly Ile His 
            260                 265                 270         


Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala Pro Ser Gly 
        275                 280                 285             


Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu Asp Leu Ser 
    290                 295                 300                 


Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu His Leu Thr 
305                 310                 315                 320 


Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg Thr Phe Glu 
                325                 330                 335     


Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu Asp Leu Ser 
            340                 345                 350         


His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala Leu Gly Ser 
        355                 360                 365             


Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp Leu Pro Pro 
    370                 375                 380                 


Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn Leu Gln Gly 
385                 390                 395                 400 


Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly Pro Ser Gly 
                405                 410                 415     


Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu Ser Leu Val 
            420                 425                 430         


Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu His Thr Pro 
        435                 440                 445             


Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu Val Ala Thr 
    450                 455                 460                 


Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu Ala Leu Gln 
465                 470                 475                 480 


Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys Phe Ile Cys 
                485                 490                 495     


Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His Leu Pro Ala 
            500                 505                 510         


Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg Asn Asn Ser 
        515                 520                 525             


Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu Thr Ser Leu 
    530                 535                 540                 


Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys Gly Asn Gly 
545                 550                 555                 560 


Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val Asp Ala Thr 
                565                 570                 575     


Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val Ser Leu Ser 
            580                 585                 590         


His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys Asn Ile Asn 
        595                 600                 605             


His His His His His His 
    610                 


<210> 2
<211> 361
<212> PRT
<213> Homo sapiens

<400> 2
Leu Ser Thr Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg 
1               5                   10                  15      


Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser 
            20                  25                  30          


Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val 
        35                  40                  45              


Leu Ala Leu Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala 
    50                  55                  60                  


Glu Pro Glu Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr 
65                  70                  75                  80  


Arg Val Leu Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys 
                85                  90                  95      


Gln Ser Thr His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg 
            100                 105                 110         


Glu Ala Val Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu 
        115                 120                 125             


Leu Arg Leu Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys 
    130                 135                 140                 


Tyr Ser Asn Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro 
145                 150                 155                 160 


Ser Asp Ser Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg 
                165                 170                 175     


Gln Trp Leu Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala 
            180                 185                 190         


His Cys Ser Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn 
        195                 200                 205             


Gly Phe Thr Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met 
    210                 215                 220                 


Asn Arg Pro Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln 
225                 230                 235                 240 


His Leu Gln Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys 
                245                 250                 255     


Phe Ser Ser Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp 
            260                 265                 270         


Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr 
        275                 280                 285             


His Ala Asn Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp 
    290                 295                 300                 


Thr Gln Tyr Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly 
305                 310                 315                 320 


Ala Ser Ala Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro 
                325                 330                 335     


Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn 
            340                 345                 350         


Met Ile Val Arg Ser Cys Lys Cys Ser 
        355                 360     


<210> 3
<211> 640
<212> PRT
<213> Homo sapiens

<400> 3
Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala Gly His 
1               5                   10                  15      


Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr 
            20                  25                  30          


Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu Cys Thr 
        35                  40                  45              


Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr Glu Gly 
    50                  55                  60                  


Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu Glu Gly 
65                  70                  75                  80  


Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val Cys Gly 
                85                  90                  95      


Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu Tyr Cys 
            100                 105                 110         


Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp Ile Asp 
        115                 120                 125             


Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val Asn Ser 
    130                 135                 140                 


Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg Gly Trp 
145                 150                 155                 160 


Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn Val Cys 
                165                 170                 175     


Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys Ser Cys 
            180                 185                 190         


His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg Asp Ile 
        195                 200                 205             


Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys Lys Asn 
    210                 215                 220                 


Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln Leu Ser 
225                 230                 235                 240 


Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His Arg His 
                245                 250                 255     


Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe Gln Cys 
            260                 265                 270         


Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His Cys Glu 
        275                 280                 285             


Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg Gly Asp 
    290                 295                 300                 


Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp Gly Phe 
305                 310                 315                 320 


Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys Glu His 
                325                 330                 335     


Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu Gly Ser 
            340                 345                 350         


Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp Gly Arg 
        355                 360                 365             


Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp Ser 
    370                 375                 380                 


His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu Cys Tyr 
385                 390                 395                 400 


Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp Val Asn 
                405                 410                 415     


Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys Glu Asn 
            420                 425                 430         


Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln Glu Tyr 
        435                 440                 445             


Ser Pro Met Thr Gly Gln Cys Arg Ser Arg Thr Ser Thr Asp Leu Asp 
    450                 455                 460                 


Val Asp Val Asp Gln Pro Lys Glu Glu Lys Lys Glu Cys Tyr Tyr Asn 
465                 470                 475                 480 


Leu Asn Asp Ala Ser Leu Cys Asp Asn Val Leu Ala Pro Asn Val Thr 
                485                 490                 495     


Lys Gln Glu Cys Cys Cys Thr Ser Gly Val Gly Trp Gly Asp Asn Cys 
            500                 505                 510         


Glu Ile Phe Pro Cys Pro Val Leu Gly Thr Ala Glu Phe Thr Glu Met 
        515                 520                 525             


Cys Pro Lys Gly Lys Gly Phe Val Pro Ala Gly Glu Ser Ser Ser Glu 
    530                 535                 540                 


Ala Gly Gly Glu Asn Tyr Lys Asp Ala Asp Glu Cys Leu Leu Phe Gly 
545                 550                 555                 560 


Gln Glu Ile Cys Lys Asn Gly Phe Cys Leu Asn Thr Arg Pro Gly Tyr 
                565                 570                 575     


Glu Cys Tyr Cys Lys Gln Gly Thr Tyr Tyr Asp Pro Val Lys Leu Gln 
            580                 585                 590         


Cys Phe Asp Met Asp Glu Cys Gln Asp Pro Ser Ser Cys Ile Asp Gly 
        595                 600                 605             


Gln Cys Val Asn Thr Glu Gly Ser Tyr Asn Cys Phe Cys Thr His Pro 
    610                 615                 620                 


Met Val Leu Asp Ala Ser Glu Lys Arg Cys Ile His His His His His 
625                 630                 635                 640 


<210> 4
<211> 5
<212> PRT
<213> Homo sapiens

<400> 4
Asp Tyr Thr Met His 
1               5   


<210> 5
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5
Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 9
<212> PRT
<213> Homo sapiens

<400> 6
Asp Ala Asp Asp Ser Thr Phe Asp Ile 
1               5                   


<210> 7
<211> 11
<212> PRT
<213> Homo sapiens

<400> 7
Arg Ala Ser Gln Ser Val Ser Arg Asn Leu Ala 
1               5                   10      


<210> 8
<211> 7
<212> PRT
<213> Homo sapiens

<400> 8
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 9
<211> 9
<212> PRT
<213> Homo sapiens

<400> 9
Gln Gln Tyr Tyr Ser Val Pro Tyr Thr 
1               5                   


<210> 10
<211> 5
<212> PRT
<213> Homo sapiens

<400> 10
Ser Tyr Ala Ile Ser 
1               5   


<210> 11
<211> 17
<212> PRT
<213> Homo sapiens

<400> 11
Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 12
<211> 12
<212> PRT
<213> Homo sapiens

<400> 12
Asp Arg Glu Trp Glu Pro Ala Tyr Gly Met Asp Val 
1               5                   10          


<210> 13
<211> 14
<212> PRT
<213> Homo sapiens

<400> 13
Ile Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 14
<211> 7
<212> PRT
<213> Homo sapiens

<400> 14
Asp Val Ser Asn Arg Pro Ser 
1               5           


<210> 15
<211> 10
<212> PRT
<213> Homo sapiens

<400> 15
Ser Ala Tyr Thr Val Ser Ser Thr Trp Val 
1               5                   10  


<210> 16
<211> 444
<212> PRT
<213> Homo sapiens

<400> 16
Glu Val Gln Leu Val Gln Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Asp Asp Ser Thr Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210> 17
<211> 214
<212> PRT
<213> Homo sapiens

<400> 17
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 18
<211> 447
<212> PRT
<213> Homo sapiens

<400> 18
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Glu Trp Glu Pro Ala Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210> 19
<211> 216
<212> PRT
<213> Homo sapiens

<400> 19
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ile Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Met Tyr Tyr Cys Ser Ala Tyr Thr Val Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


