                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  NOVEL FATTY ACID MODIFIED UROCORTIN-2 ANALOGS FOR THE TREATMENT 
       OF DIABETES AND CHRONIC KIDNEY DISEASE 

<130>  X21061

<150>  62/362711
<151>  2016-07-15

<150>  62/491385
<151>  2017-04-28

<150>  62/431682
<151>  2016-12-08

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)16-COO
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  1

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  2
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is Lys which is chemically modified through 
       conjugation to the epsilon-amino group of the Lys side-chain with
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)18-CO2
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  2

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  3
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)16-COO
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  3

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  4
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)18-CO2
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  4

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)18-COO
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  5

Ile Val Thr Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  6
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)18-COO
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  6

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  7
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)18-COO
       H

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  7

Ile Val Thr Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Ile 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Thr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Leu or Ile

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)x-CO2H
       where x is 16 or 18

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Gln or Glu

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  8

Ile Val Xaa Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Xaa 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Xaa Ile Leu Ala Gln Val 
        35              


<210>  9
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO
       -(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  9

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO
       -(CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  10

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  11
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-(gamma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  11

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gam
       ma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  12

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(ga
       mma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  13

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  14
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gamma-glu)-(gam
       ma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  14

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  15

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Ala Arg Ala Arg Ala Ala Arg Glu Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Thr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Leu or Ile

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at 29 is modified at the epsilon-amine with -X5-X6, where X5 
       is 1 to 4 amino acids and/or 1 to 4 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl) moieties; X6 is C14-C24 
       fatty acid.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Gln or Glu

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  16

Ile Val Xaa Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Xaa 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Xaa Ile Leu Ala Gln Val 
        35              


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO-(CH2)x-COOH
       , where x is 16 or 18

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  17

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  18
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Thr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Gln or Glu

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  18

Ile Val Xaa Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Xaa 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Xaa Ile Leu Ala Gln Val 
        35              


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Glu Lys Gln Glu Lys Glu Lys Gln 
1               5               


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  20

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  21
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys at position 14 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  21

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Lys Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Lys at position 15 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gama-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  22

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Lys Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  23
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  23

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Lys Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  24
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys at position 19 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  24

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Lys Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  25
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  25

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  26
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Lys at position 21 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  26

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Lys Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Lys at position 22 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  27

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Lys Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Lys at position 23 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  28

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Lys at position 24 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  29

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Lys Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  30
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  30

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  31
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with (gamma 
       -glu)-(gamma-glu)- CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  31

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gamma-glu)- CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  32

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  33

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Lys Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  34
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)- CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  34

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Lys Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  35
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Lys at position 27 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  35

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Lys Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Lys at position 28 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  36

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Lys Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  37
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  37

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  38
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  38

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  39
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Lys at position 30 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-CO-(CH2)14-CH3

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  39

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Lys Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val 
        35              


<210>  40
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys at position 14 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  40

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Lys Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  41
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Lys at position 15 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  41

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Lys Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  42
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Lys at position 16 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  42

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Lys 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  43

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Lys Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  44
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Lys at position 18 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  44

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Lys Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  45
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Lys at position 21 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  45

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Lys Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  46
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  46

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  47
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  47

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Lys Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  48
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  48

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala His Val 
        35              


<210>  49
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Lys at position 10 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  49

Ile Val Leu Ser Leu Asp Val Pro Ile Lys Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  50
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  50

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Lys Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  51
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  51

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Lys Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  52

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  53
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  53

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Lys Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Glu Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  54
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  54

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Lys Gln Ala Thr Glu Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  55
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  55

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Glu Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  56
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(gamma-glu)-CO-
       (CH2)16-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  56

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Glu Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  57
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gamma-glu)-(gamma-glu)-CO-(
       CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  57

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Glu Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  58
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with (gamma-glu) 
       -(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  58

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Glu Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  59
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gamma-glu)-(gam
       ma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  59

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Glu Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  60
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)2-CO
       -(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  60

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  61
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-gu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gamma-glu)-(gamm
       a-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  61

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  62
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(ga
       mma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  62

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  63
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)-(gam
       ma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  63

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-(gamma-glu)-(gamma-glu)-(gamma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  64

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  65
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(ga
       mma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  65

Ile Val Thr Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Gln Ile Leu Ala Gln Val 
        35              


<210>  66
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (gamma-glu)-([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-glu)-(ga
       mma-glu)-CO-(CH2)18-COOH

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at position 38 is amidated at the C-terminal carboxyl

<400>  66

Ile Val Thr Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Lys Thr Asn Ala 
            20                  25                  30          


Glu Ile Leu Ala Gln Val 
        35              


<210>  67
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  UNMODIFIED

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at postiion 3 is Leu or Thr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at postiion 16 is Leu or Ile

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Lys at position 23 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at postiion 30 is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at postiion 33 is Gln, Arg, or Glu

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at postiion 37 is Gln, His, or Arg

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at postiion 38 is amidated at the C-terminal carboxyl

<400>  67

Ile Val Xaa Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Xaa 
1               5                   10                  15      


Glu Gln Glu Lys Gln Glu Lys Glu Lys Gln Gln Ala Thr Xaa Asn Ala 
            20                  25                  30          


Xaa Ile Leu Ala Xaa Val 
        35              


<210>  68
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  UNMODIFIED

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Thr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Gly or Lys

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Lys at position 10 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys at position 14 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is Ile or Lys

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Lys at position 15 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Leu or Lys

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Lys at position 16 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Leu, Ile, or Lys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is Glu or Lys

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Lys at position 18 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Gln or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys at position 19 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position 19 is Glu or Lys

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Lys at position 21 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is Gln or Lys

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Lys at position 22 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Glu or Lys

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Lys at position 23 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Lys at position 24 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is Glu or Lys

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Lys at position 25 may be modified as described herein.

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys at position 26 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Gln or Lys

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Lys at position 27 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Gln or Lys

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Lys at position 28 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Ala or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lys at position 29 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Lys

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Lys at position 30 may be modified as described herein.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Thr, Glu, or Lys

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Gln, Arg, or Glu

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at position 37 is Gln, His, or Arg

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Val at postiion 38 is amidated at the C-terminal carboxyl

<400>  68

Ile Val Xaa Ser Leu Asp Val Pro Ile Xaa Leu Leu Gln Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Lys Xaa Xaa Lys Xaa Lys Xaa Xaa Xaa Xaa Xaa Asn Ala 
            20                  25                  30          


Xaa Ile Leu Ala Xaa Val 
        35              


