                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Treating PTEN Deficient Epithelial Cancers Using A 
       Combination Of Anti-PI3KBeta And Anti-Immune Checkpoint Agents

<130>  DFS-166.25

<140>  PCT/US2017/041490
<141>  2017-07-11

<150>  62/360,596
<151>  2016-07-11

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  3207
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcctccac gaccatcatc aggtgaactg tggggcatcc acttgatgcc cccaagaatc       60

ctagtagaat gtttactacc aaatggaatg atagtgactt tagaatgcct ccgtgaggct      120

acattaataa ccataaagca tgaactattt aaagaagcaa gaaaataccc cctccatcaa      180

cttcttcaag atgaatcttc ttacattttc gtaagtgtta ctcaagaagc agaaagggaa      240

gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa      300

gtaattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgct      360

atcggcatgc cagtgtgtga atttgatatg gttaaagatc cagaagtaca ggacttccga      420

agaaatattc tgaacgtttg taaagaagct gtggatctta gggacctcaa ttcacctcat      480

agtagagcaa tgtatgtcta tcctccaaat gtagaatctt caccagaatt gccaaagcac      540

atatataata aattagataa agggcaaata atagtggtga tctgggtaat agtttctcca      600

aataatgaca agcagaagta tactctgaaa atcaaccatg actgtgtacc agaacaagta      660

attgctgaag caatcaggaa aaaaactcga agtatgttgc tatcctctga acaactaaaa      720

ctctgtgttt tagaatatca gggcaagtat attttaaaag tgtgtggatg tgatgaatac      780

ttcctagaaa aatatcctct gagtcagtat aagtatataa gaagctgtat aatgcttggg      840

aggatgccca atttgatgtt gatggctaaa gaaagccttt attctcaact gccaatggac      900

tgttttacaa tgccatctta ttccagacgc atttccacag ctacaccata tatgaatgga      960

gaaacatcta caaaatccct ttgggttata aatagtgcac tcagaataaa aattctttgt     1020

gcaacctacg tgaatgtaaa tattcgagac attgataaga tctatgttcg aacaggtatc     1080

taccatggag gagaaccctt atgtgacaat gtgaacactc aaagagtacc ttgttccaat     1140

cccaggtgga atgaatggct gaattatgat atatacattc ctgatcttcc tcgtgctgct     1200

cgactttgcc tttccatttg ctctgttaaa ggccgaaagg gtgctaaaga ggaacactgt     1260

ccattggcat ggggaaatat aaacttgttt gattacacag acactctagt atctggaaaa     1320

atggctttga atctttggcc agtacctcat ggattagaag atttgctgaa ccctattggt     1380

gttactggat caaatccaaa taaagaaact ccatgcttag agttggagtt tgactggttc     1440

agcagtgtgg taaagttccc agatatgtca gtgattgaag agcatgccaa ttggtctgta     1500

tcccgagaag caggatttag ctattcccac gcaggactga gtaacagact agctagagac     1560

aatgaattaa gggaaaatga caaagaacag ctcaaagcaa tttctacacg agatcctctc     1620

tctgaaatca ctgagcagga gaaagatttt ctatggagtc acagacacta ttgtgtaact     1680

atccccgaaa ttctacccaa attgcttctg tctgttaaat ggaattctag agatgaagta     1740

gcccagatgt attgcttggt aaaagattgg cctccaatca aacctgaaca ggctatggaa     1800

cttctggact gtaattaccc agatcctatg gttcgaggtt ttgctgttcg gtgcttggaa     1860

aaatatttaa cagatgacaa actttctcag tatttaattc agctagtaca ggtcctaaaa     1920

tatgaacaat atttggataa cttgcttgtg agatttttac tgaagaaagc attgactaat     1980

caaaggattg ggcacttttt cttttggcat ttaaaatctg agatgcacaa taaaacagtt     2040

agccagaggt ttggcctgct tttggagtcc tattgtcgtg catgtgggat gtatttgaag     2100

cacctgaata ggcaagtcga ggcaatggaa aagctcatta acttaactga cattctcaaa     2160

caggagaaga aggatgaaac acaaaaggta cagatgaagt ttttagttga gcaaatgagg     2220

cgaccagatt tcatggatgc tctacagggc tttctgtctc ctctaaaccc tgctcatcaa     2280

ctaggaaacc tcaggcttga agagtgtcga attatgtcct ctgcaaaaag gccactgtgg     2340

ttgaattggg agaacccaga catcatgtca gagttactgt ttcagaacaa tgagatcatc     2400

tttaaaaatg gggatgattt acggcaagat atgctaacac ttcaaattat tcgtattatg     2460

gaaaatatct ggcaaaatca aggtcttgat cttcgaatgt taccttatgg ttgtctgtca     2520

atcggtgact gtgtgggact tattgaggtg gtgcgaaatt ctcacactat tatgcaaatt     2580

cagtgcaaag gcggcttgaa aggtgcactg cagttcaaca gccacacact acatcagtgg     2640

ctcaaagaca agaacaaagg agaaatatat gatgcagcca ttgacctgtt tacacgttca     2700

tgtgctggat actgtgtagc taccttcatt ttgggaattg gagatcgtca caatagtaac     2760

atcatggtga aagacgatgg acaactgttt catatagatt ttggacactt tttggatcac     2820

aagaagaaaa aatttggtta taaacgagaa cgtgtgccat ttgttttgac acaggatttc     2880

ttaatagtga ttagtaaagg agcccaagaa tgcacaaaga caagagaatt tgagaggttt     2940

caggagatgt gttacaaggc ttatctagct attcgacagc atgccaatct cttcataaat     3000

cttttctcaa tgatgcttgg ctctggaatg ccagaactac aatcttttga tgacattgca     3060

tacattcgaa agaccctagc cttagataaa actgagcaag aggctttgga gtatttcatg     3120

aaacaaatga atgatgcaca tcatggtggc tggacaacaa aaatggattg gatcttccac     3180

acaattaaac agcatgcatt gaactga                                         3207


<210>  2
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  3
<211>  3207
<212>  DNA
<213>  Mus musculus

<400>  3
atgcctccac gaccatcttc gggtgaactg tggggcatcc acttgatgcc cccacgaatc       60

ctagtggaat gtttactccc caatggaatg atagtgactt tagaatgcct ccgtgaggcc      120

acactcgtca ccatcaaaca tgaactgttc agagaggcca ggaaataccc tctccatcag      180

cttctgcaag acgaaacttc ttacattttc gtaagtgtca cccaagaagc agaaagggaa      240

gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa      300

gttattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgtt      360

attggcatgc cagtgtgtga atttgatatg gttaaagatc cagaagtcca agactttcga      420

aggaacattc tgaatgtttg caaagaagct gtggacctgc gggatctcaa ctcgcctcat      480

agcagagcaa tgtatgtcta ccctccaaat gtcgagtctt ccccagaact gccaaagcac      540

atctacaaca agttagataa aggacaaatc atagtggtga tttgggtaat agtctctcca      600

aacaacgaca agcagaagta cactctgaag atcaatcatg actgtgtgcc agagcaagtc      660

attgctgaag ccatcaggaa aaagactcgg agcatgttgt tgtcctctga gcagctgaaa      720

ctctgtgtct tagaatatca gggcaagtat attctgaaag tgtgtggctg tgacgaatac      780

ttcctggaaa agtaccctct gagtcagtac aagtacataa gaagctgtat aatgctgggg      840

aggatgccca acttgatgct gatggccaaa gaaagcctat actctcagct gccgattgat      900

agcttcacca tgccgtcata ctccaggcgc atctccacag ccacacccta catgaatgga      960

gagacatcta cgaaatccct ctgggtcata aatagtgcgc tcagaataaa aattctttgt     1020

gcaacctatg taaatgtaaa tattcgagac attgataaga tctatgttcg aacaggtatc     1080

taccatggag gagaaccctt atgtgacaat gtgaacactc aaagagtacc ttgttccaat     1140

cctaggtgga atgaatggct gaattatgat atatacattc ctgatcttcc tcgtgctgcg     1200

cgcctttgcc tttcaatctg ctctgttaaa ggccgaaagg gtgctaagga ggagcactgt     1260

ccgttggcct ggggaaacat aaacttgttt gattatacag acaccctagt gtccgggaaa     1320

atggctttga atctctggcc tgtaccgcat gggttagaag atctgctgaa ccctattggt     1380

gttactgggt caaatccaaa taaagaaact ccatgcttag agttggagtt tgattggttc     1440

agcagtgtgg tgaagtttcc agacatgtct gtgatcgaag aacatgccaa ttggtccgtg     1500

tcccgagaag ctggattcag ttactcccat acaggactga gtaacagact agccagagac     1560

aatgagttaa gagaaaatga caaggaacag ctccgagcac tttgcacccg ggacccacta     1620

tctgaaatca ctgaacaaga gaaagacttc ctatggagcc acagacacta ctgcgtaact     1680

attcctgaaa tcctacccaa attgcttctg tctgtcaagt ggaattccag agacgaagtg     1740

gcccagatgt actgcttagt aaaagattgg cctccaatca aaccagagca agccatggaa     1800

ctcctggact gtaactatcc agatcctatg gttcggagtt ttgctgttcg gtgcttagaa     1860

aaatatttaa cagatgacaa actttctcag tacctcattc aacttgtaca ggtcttaaaa     1920

tatgaacagt atttggataa cctgcttgtg agatttttac tcaagaaagc attgacaaat     1980

caaaggattg gccatttttt cttttggcat ttaaaatctg agatgcacaa taagactgtc     2040

agtcagaggt ttggcctgct attggagtcc tactgccgtg cctgtgggat gtatctgaag     2100

cacctgaaca gacaagtaga ggccatggag aagctcatca acctaacgga catccttaag     2160

caggagaaga aggatgagac acaaaaggta cagatgaagt ttttggttga acagatgaga     2220

cagccagact tcatggatgc tttgcagggt tttctgtccc ctctgaatcc tgctcaccaa     2280

ctaggaaacc tcaggcttga agagtgtcga attatgtcct ctgcaaaaag gccactgtgg     2340

ttgaattggg agaacccaga catcatgtca gagctactgt ttcagaacaa tgagatcatc     2400

tttaaaaatg gcgacgactt acggcaagat atgttaaccc ttcagatcat ccgaatcatg     2460

gagaacatct ggcaaaacca aggccttgac cttcgcatgc taccttatgg ctgtctatcc     2520

attggggact gtgtgggtct catcgaggtg gtgagaaact ctcacaccat catgcaaatc     2580

cagtgcaaag gaggcctgaa gggggcgctg cagttcaaca gccacacact gcatcaatgg     2640

ctcaaggaca agaacaaggg cgagatatat gatgcagcca ttgacctgtt cactcggtcc     2700

tgcgctgggt actgcgtggc aacctttatc ttgggaattg gagaccggca caacagcaac     2760

atcatggtga aagatgacgg acagctgttt catatagatt ttgggcactt tttggatcac     2820

aagaagaaaa aatttggcta taagcgggaa cgtgtgccat ttgtgttgac acaggatttc     2880

ttgattgtga ttagtaaggg agcacaagag tacaccaaga ccagagagtt tgagaggttt     2940

caggagatgt gttacaaggc ttacctagca attcggcagc atgccaatct cttcatcaac     3000

cttttttcaa tgatgcttgg ctctggaatg ccagaactac aatcttttga tgacattgca     3060

tatatccgaa agactctagc cttggacaaa actgagcaag aagctttgga atatttcaca     3120

aagcaaatga atgatgcaca tcatggtgga tggacgacaa aaatggattg gatcttccac     3180

accatcaagc agcatgcttt gaactga                                         3207


<210>  4
<211>  1068
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Val Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Arg Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Thr Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Val Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Ile Asp Ser Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Thr Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Arg Ala Leu Cys Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Ser Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Gln Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Tyr Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Thr  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  5
<211>  3207
<212>  DNA
<213>  Mus musculus

<400>  5
atgcctccac gaccatcttc gggtgaactg tggggcatcc acttgatgcc cccacgaatc       60

ctagtggaat gtttactccc caatggaatg atagtgactt tagaatgcct ccgtgaggcc      120

acactcgtca ccatcaaaca tgaactgttc agagaggcca ggaaataccc tctccatcag      180

cttctgcaag acgaaacttc ttacattttc gtaagtgtca cccaagaagc agaaagggaa      240

gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa      300

gttattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgtt      360

attggcatgc cagtgtgtga atttgatatg gttaaagatc cagaagtcca agactttcga      420

aggaacattc tgaatgtttg caaagaagct gtggacctgc gggatctcaa ctcgcctcat      480

agcagagcaa tgtatgtcta ccctccaaat gtcgagtctt ccccagaact gccaaagcac      540

atctacaaca agttagataa aggacaaatc atagtggtga tttgggtaat agtctctcca      600

aacaacgaca agcagaagta cactctgaag atcaatcatg actgtgtgcc agagcaagtc      660

attgctgaag ccatcaggaa aaagactcgg agcatgttgt tgtcctctga gcagctgaaa      720

ctctgtgtct tagaatatca gggcaagtat attctgaaag tgtgtggctg tgacgaatac      780

ttcctggaaa agtaccctct gagtcagtac aagtacataa gaagctgtat aatgctgggg      840

aggatgccca acttgatgct gatggccaaa gaaagcctat actctcagct gccgattgat      900

agcttcacca tgccgtcata ctccaggcgc atctccacag ccacacccta catgaatgga      960

gagacatcta cgaaatccct ctgggtcata aatagtgcgc tcagaataaa aattctttgt     1020

gcaacctatg taaatgtaaa tattcgagac attgataaga tctatgttcg aacaggtatc     1080

taccatggag gagaaccctt atgtgacaat gtgaacactc aaagagtacc ttgttccaat     1140

cctaggtgga atgaatggct gaattatgat atatacattc ctgatcttcc tcgtgctgcg     1200

cgcctttgcc tttcaatctg ctctgttaaa ggccgaaagg gtgctaagga ggagcactgt     1260

ccgttggcct ggggaaacat aaacttgttt gattatacag acaccctagt gtccgggaaa     1320

atggctttga atctctggcc tgtaccgcat gggttagaag atctgctgaa ccctattggt     1380

gttactgggt caaatccaaa taaagaaact ccatgcttag agttggagtt tgattggttc     1440

agcagtgtgg tgaagtttcc agacatgtct gtgatcgaag aacatgccaa ttggtccgtg     1500

tcccgagaag ctggattcag ttactcccat acaggactga gtaacagact agccagagac     1560

aatgagttaa gagaaaatga caaggaacag ctccgagcac tttgcacccg ggacccacta     1620

tctgaaatca ctgaacaaga gaaagacttc ctatggagcc acagacacta ctgcgtaact     1680

attcctgaaa tcctacccaa attgcttctg tctgtcaagt ggaattccag agacgaagtg     1740

gcccagatgt actgcttagt aaaagattgg cctccaatca aaccagagca agccatggaa     1800

ctcctggact gtaactatcc agatcctatg gttcggagtt ttgctgttcg gtgcttagaa     1860

aaatatttaa cagatgacaa actttctcag tacctcattc aacttgtaca ggtcttaaaa     1920

tatgaacagt atttggataa cctgcttgtg agatttttac tcaagaaagc attgacaaat     1980

caaaggattg gccatttttt cttttggcat ttaaaatctg agatgcacaa taagactgtc     2040

agtcagaggt ttggcctgct attggagtcc tactgccgtg cctgtgggat gtatctgaag     2100

cacctgaaca gacaagtaga ggccatggag aagctcatca acctaacgga catccttaag     2160

caggagaaga aggatgagac acaaaaggta cagatgaagt ttttggttga acagatgaga     2220

cagccagact tcatggatgc tttgcagggt tttctgtccc ctctgaatcc tgctcaccaa     2280

ctaggaaacc tcaggcttga agagtgtcga attatgtcct ctgcaaaaag gccactgtgg     2340

ttgaattggg agaacccaga catcatgtca gagctactgt ttcagaacaa tgagatcatc     2400

tttaaaaatg gcgacgactt acggcaagat atgttaaccc ttcagatcat ccgaatcatg     2460

gagaacatct ggcaaaacca aggccttgac cttcgcatgc taccttatgg ctgtctatcc     2520

attggggact gtgtgggtct catcgaggtg gtgagaaact ctcacaccat catgcaaatc     2580

cagtgcaaag gaggcctgaa gggggcgctg cagttcaaca gccacacact gcatcaatgg     2640

ctcaaggaca agaacaaggg cgagatatat gatgcagcca ttgacctgtt cactcggtcc     2700

tgcgctgggt actgcgtggc aacctttatc ttgggaattg gagaccggca caacagcaac     2760

atcatggtga aagatgacgg acagctgttt catatagatt ttgggcactt tttggatcac     2820

aagaagaaaa aatttggcta taagcgggaa cgtgtgccat ttgtgttgac acaggatttc     2880

ttgattgtga ttagtaaggg agcacaagag tacaccaaga ccagagagtt tgagaggttt     2940

caggagatgt gttacaaggc ttacctagca attcggcagc atgccaatct cttcatcaac     3000

cttttttcaa tgatgcttgg ctctggaatg ccagaactac aatcttttga tgacattgca     3060

tatatccgaa agactctagc cttggacaaa actgagcaag aagctttgga atatttcaca     3120

aagcaaatga atgatgcaca tcatggtgga tggacgacaa aaatggattg gatcttccac     3180

accatcaagc agcatgcttt gaactga                                         3207


<210>  6
<211>  1068
<212>  PRT
<213>  Mus musculus

<400>  6

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Val Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Arg Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Thr Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Val Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Ile Asp Ser Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Thr Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Arg Ala Leu Cys Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Ser Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Gln Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Tyr Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Thr  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  7
<211>  3213
<212>  DNA
<213>  Homo sapiens

<400>  7
atgtgcttca gtttcataat gcctcctgct atggcagaca tccttgacat ctgggcggtg       60

gattcacaga tagcatctga tggctccata cctgtggatt tccttttgcc cactgggatt      120

tatatccagt tggaggtacc tcgggaagct accatttctt atattaagca gatgttatgg      180

aagcaagttc acaattaccc aatgttcaac ctccttatgg atattgactc ctatatgttt      240

gcatgtgtga atcagactgc tgtatatgag gagcttgaag atgaaacacg aagactctgt      300

gatgtcagac cttttcttcc agttctcaaa ttagtgacaa gaagttgtga cccaggggaa      360

aaattagact caaaaattgg agtccttata ggaaaaggtc tgcatgaatt tgattccttg      420

aaggatcctg aagtaaatga atttcgaaga aaaatgcgca aattcagcga ggaaaaaatc      480

ctgtcacttg tgggattgtc ttggatggac tggctaaaac aaacatatcc accagagcat      540

gaaccatcca tccctgaaaa cttagaagat aaactttatg ggggaaagct catcgtagct      600

gttcattttg aaaactgcca ggacgtgttt agctttcaag tgtctcctaa tatgaatcct      660

atcaaagtaa atgaattggc aatccaaaaa cgtttgacta ttcatgggaa ggaagatgaa      720

gttagcccct atgattatgt gttgcaagtc agcgggagag tagaatatgt ttttggtgat      780

catccactaa ttcagttcca gtatatccgg aactgtgtga tgaacagagc cctgccccat      840

tttatacttg tggaatgctg caagatcaag aaaatgtatg aacaagaaat gattgccata      900

gaggctgcca taaatcgaaa ttcatctaat cttcctcttc cattaccacc aaagaaaaca      960

cgaattattt ctcatgtttg ggaaaataac aaccctttcc aaattgtctt ggttaaggga     1020

aataaactta acacagagga aactgtaaaa gttcatgtca gggctggtct ttttcatggt     1080

actgagctcc tgtgtaaaac catcgtaagc tcagaggtat cagggaaaaa tgatcatatt     1140

tggaatgaac cactggaatt tgatattaat atttgtgact taccaagaat ggctcgatta     1200

tgttttgctg tttatgcagt tttggataaa gtaaaaacga agaaatcaac gaaaactatt     1260

aatccctcta aatatcagac catcaggaaa gctggaaaag tgcattatcc tgtagcgtgg     1320

gtaaatacga tggtttttga ctttaaagga caattgagaa ctggagacat aatattacac     1380

agctggtctt catttcctga tgaactcgaa gaaatgttga atccaatggg aactgttcaa     1440

acaaatccat atactgaaaa tgcaacagct ttgcatgtta aatttccaga gaataaaaaa     1500

caaccttatt attaccctcc cttcgataag attattgaaa aggcagctga gattgcaagc     1560

agtgatagtg ctaatgtgtc aagtcgaggt ggaaaaaagt ttcttcctgt attgaaagaa     1620

atcttggaca gggatccctt gtctcaactg tgtgaaaatg aaatggatct tatttggact     1680

ttgcgacaag actgccgaga gattttccca caatcactgc caaaattact gctgtcaatc     1740

aagtggaata aacttgagga tgttgctcag cttcaggcgc tgcttcagat ttggcctaaa     1800

ctgccccccc gggaggccct agagcttctg gatttcaact atccagacca gtacgttcga     1860

gaatatgctg taggctgcct gcgacagatg agtgatgaag aactttctca atatctttta     1920

caactggtgc aagtgttaaa atatgagcct tttcttgatt gtgccctctc tagattccta     1980

ttagaaagag cacttggtaa tcggaggata gggcagtttc tattttggca tcttaggtca     2040

gaagtgcaca ttcctgctgt ctcagtacaa tttggtgtca tccttgaagc atactgccgg     2100

ggaagtgtgg ggcacatgaa agtgctttct aagcaggttg aagcactcaa taagttaaaa     2160

actttaaata gtttaatcaa actgaatgcc gtgaagttaa acagagccaa agggaaggag     2220

gccatgcata cctgtttaaa acagagtgct taccgggaag ccctctctga cctgcagtca     2280

cccctgaacc catgtgttat cctctcagaa ctctatgttg aaaagtgcaa atacatggat     2340

tccaaaatga agcctttgtg gctggtatac aataacaagg tatttggtga ggattcagtt     2400

ggagtgattt ttaaaaatgg tgatgattta cgacaggata tgttgacact ccaaatgttg     2460

cgcttgatgg atttactctg gaaagaagct ggtttggatc ttcggatgtt gccttatggc     2520

tgtttagcaa caggagatcg ctctggcctc attgaagttg tgagcacctc tgaaacaatt     2580

gctgacattc agctgaacag tagcaatgtg gctgctgcag cagccttcaa caaagatgcc     2640

cttctgaact ggcttaaaga atacaactct ggggatgacc tggaccgagc cattgaggaa     2700

tttacactgt cctgtgctgg ctactgtgta gcttcttatg tccttgggat tggtgacaga     2760

catagtgaca acatcatggt caaaaaaact ggccagctct tccacattga ctttggacat     2820

attcttggaa atttcaaatc taagtttggc attaaaaggg agcgagtgcc ttttattctt     2880

acctatgatt tcatccatgt cattcaacaa ggaaaaacag gaaatacaga aaagtttggc     2940

cggttccgcc agtgttgtga ggatgcatat ctgattttac gacggcatgg gaatctcttc     3000

atcactctct ttgcgctgat gttgactgca gggcttcctg aactcacatc agtcaaagat     3060

atacagtatc ttaaggactc tcttgcatta gggaagagtg aagaagaagc actcaaacag     3120

tttaagcaaa aatttgatga ggcgctcagg gaaagctgga ctactaaagt gaactggatg     3180

gcccacacag ttcggaaaga ctacagatct taa                                  3213


<210>  8
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Cys Phe Ser Phe Ile Met Pro Pro Ala Met Ala Asp Ile Leu Asp 
1               5                   10                  15      


Ile Trp Ala Val Asp Ser Gln Ile Ala Ser Asp Gly Ser Ile Pro Val 
            20                  25                  30          


Asp Phe Leu Leu Pro Thr Gly Ile Tyr Ile Gln Leu Glu Val Pro Arg 
        35                  40                  45              


Glu Ala Thr Ile Ser Tyr Ile Lys Gln Met Leu Trp Lys Gln Val His 
    50                  55                  60                  


Asn Tyr Pro Met Phe Asn Leu Leu Met Asp Ile Asp Ser Tyr Met Phe 
65                  70                  75                  80  


Ala Cys Val Asn Gln Thr Ala Val Tyr Glu Glu Leu Glu Asp Glu Thr 
                85                  90                  95      


Arg Arg Leu Cys Asp Val Arg Pro Phe Leu Pro Val Leu Lys Leu Val 
            100                 105                 110         


Thr Arg Ser Cys Asp Pro Gly Glu Lys Leu Asp Ser Lys Ile Gly Val 
        115                 120                 125             


Leu Ile Gly Lys Gly Leu His Glu Phe Asp Ser Leu Lys Asp Pro Glu 
    130                 135                 140                 


Val Asn Glu Phe Arg Arg Lys Met Arg Lys Phe Ser Glu Glu Lys Ile 
145                 150                 155                 160 


Leu Ser Leu Val Gly Leu Ser Trp Met Asp Trp Leu Lys Gln Thr Tyr 
                165                 170                 175     


Pro Pro Glu His Glu Pro Ser Ile Pro Glu Asn Leu Glu Asp Lys Leu 
            180                 185                 190         


Tyr Gly Gly Lys Leu Ile Val Ala Val His Phe Glu Asn Cys Gln Asp 
        195                 200                 205             


Val Phe Ser Phe Gln Val Ser Pro Asn Met Asn Pro Ile Lys Val Asn 
    210                 215                 220                 


Glu Leu Ala Ile Gln Lys Arg Leu Thr Ile His Gly Lys Glu Asp Glu 
225                 230                 235                 240 


Val Ser Pro Tyr Asp Tyr Val Leu Gln Val Ser Gly Arg Val Glu Tyr 
                245                 250                 255     


Val Phe Gly Asp His Pro Leu Ile Gln Phe Gln Tyr Ile Arg Asn Cys 
            260                 265                 270         


Val Met Asn Arg Ala Leu Pro His Phe Ile Leu Val Glu Cys Cys Lys 
        275                 280                 285             


Ile Lys Lys Met Tyr Glu Gln Glu Met Ile Ala Ile Glu Ala Ala Ile 
    290                 295                 300                 


Asn Arg Asn Ser Ser Asn Leu Pro Leu Pro Leu Pro Pro Lys Lys Thr 
305                 310                 315                 320 


Arg Ile Ile Ser His Val Trp Glu Asn Asn Asn Pro Phe Gln Ile Val 
                325                 330                 335     


Leu Val Lys Gly Asn Lys Leu Asn Thr Glu Glu Thr Val Lys Val His 
            340                 345                 350         


Val Arg Ala Gly Leu Phe His Gly Thr Glu Leu Leu Cys Lys Thr Ile 
        355                 360                 365             


Val Ser Ser Glu Val Ser Gly Lys Asn Asp His Ile Trp Asn Glu Pro 
    370                 375                 380                 


Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu Pro Arg Met Ala Arg Leu 
385                 390                 395                 400 


Cys Phe Ala Val Tyr Ala Val Leu Asp Lys Val Lys Thr Lys Lys Ser 
                405                 410                 415     


Thr Lys Thr Ile Asn Pro Ser Lys Tyr Gln Thr Ile Arg Lys Ala Gly 
            420                 425                 430         


Lys Val His Tyr Pro Val Ala Trp Val Asn Thr Met Val Phe Asp Phe 
        435                 440                 445             


Lys Gly Gln Leu Arg Thr Gly Asp Ile Ile Leu His Ser Trp Ser Ser 
    450                 455                 460                 


Phe Pro Asp Glu Leu Glu Glu Met Leu Asn Pro Met Gly Thr Val Gln 
465                 470                 475                 480 


Thr Asn Pro Tyr Thr Glu Asn Ala Thr Ala Leu His Val Lys Phe Pro 
                485                 490                 495     


Glu Asn Lys Lys Gln Pro Tyr Tyr Tyr Pro Pro Phe Asp Lys Ile Ile 
            500                 505                 510         


Glu Lys Ala Ala Glu Ile Ala Ser Ser Asp Ser Ala Asn Val Ser Ser 
        515                 520                 525             


Arg Gly Gly Lys Lys Phe Leu Pro Val Leu Lys Glu Ile Leu Asp Arg 
    530                 535                 540                 


Asp Pro Leu Ser Gln Leu Cys Glu Asn Glu Met Asp Leu Ile Trp Thr 
545                 550                 555                 560 


Leu Arg Gln Asp Cys Arg Glu Ile Phe Pro Gln Ser Leu Pro Lys Leu 
                565                 570                 575     


Leu Leu Ser Ile Lys Trp Asn Lys Leu Glu Asp Val Ala Gln Leu Gln 
            580                 585                 590         


Ala Leu Leu Gln Ile Trp Pro Lys Leu Pro Pro Arg Glu Ala Leu Glu 
        595                 600                 605             


Leu Leu Asp Phe Asn Tyr Pro Asp Gln Tyr Val Arg Glu Tyr Ala Val 
    610                 615                 620                 


Gly Cys Leu Arg Gln Met Ser Asp Glu Glu Leu Ser Gln Tyr Leu Leu 
625                 630                 635                 640 


Gln Leu Val Gln Val Leu Lys Tyr Glu Pro Phe Leu Asp Cys Ala Leu 
                645                 650                 655     


Ser Arg Phe Leu Leu Glu Arg Ala Leu Gly Asn Arg Arg Ile Gly Gln 
            660                 665                 670         


Phe Leu Phe Trp His Leu Arg Ser Glu Val His Ile Pro Ala Val Ser 
        675                 680                 685             


Val Gln Phe Gly Val Ile Leu Glu Ala Tyr Cys Arg Gly Ser Val Gly 
    690                 695                 700                 


His Met Lys Val Leu Ser Lys Gln Val Glu Ala Leu Asn Lys Leu Lys 
705                 710                 715                 720 


Thr Leu Asn Ser Leu Ile Lys Leu Asn Ala Val Lys Leu Asn Arg Ala 
                725                 730                 735     


Lys Gly Lys Glu Ala Met His Thr Cys Leu Lys Gln Ser Ala Tyr Arg 
            740                 745                 750         


Glu Ala Leu Ser Asp Leu Gln Ser Pro Leu Asn Pro Cys Val Ile Leu 
        755                 760                 765             


Ser Glu Leu Tyr Val Glu Lys Cys Lys Tyr Met Asp Ser Lys Met Lys 
    770                 775                 780                 


Pro Leu Trp Leu Val Tyr Asn Asn Lys Val Phe Gly Glu Asp Ser Val 
785                 790                 795                 800 


Gly Val Ile Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr 
                805                 810                 815     


Leu Gln Met Leu Arg Leu Met Asp Leu Leu Trp Lys Glu Ala Gly Leu 
            820                 825                 830         


Asp Leu Arg Met Leu Pro Tyr Gly Cys Leu Ala Thr Gly Asp Arg Ser 
        835                 840                 845             


Gly Leu Ile Glu Val Val Ser Thr Ser Glu Thr Ile Ala Asp Ile Gln 
    850                 855                 860                 


Leu Asn Ser Ser Asn Val Ala Ala Ala Ala Ala Phe Asn Lys Asp Ala 
865                 870                 875                 880 


Leu Leu Asn Trp Leu Lys Glu Tyr Asn Ser Gly Asp Asp Leu Asp Arg 
                885                 890                 895     


Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala Gly Tyr Cys Val Ala Ser 
            900                 905                 910         


Tyr Val Leu Gly Ile Gly Asp Arg His Ser Asp Asn Ile Met Val Lys 
        915                 920                 925             


Lys Thr Gly Gln Leu Phe His Ile Asp Phe Gly His Ile Leu Gly Asn 
    930                 935                 940                 


Phe Lys Ser Lys Phe Gly Ile Lys Arg Glu Arg Val Pro Phe Ile Leu 
945                 950                 955                 960 


Thr Tyr Asp Phe Ile His Val Ile Gln Gln Gly Lys Thr Gly Asn Thr 
                965                 970                 975     


Glu Lys Phe Gly Arg Phe Arg Gln Cys Cys Glu Asp Ala Tyr Leu Ile 
            980                 985                 990         


Leu Arg Arg His Gly Asn Leu Phe  Ile Thr Leu Phe Ala  Leu Met Leu 
        995                 1000                 1005             


Thr Ala  Gly Leu Pro Glu Leu  Thr Ser Val Lys Asp  Ile Gln Tyr 
    1010                 1015                 1020             


Leu Lys  Asp Ser Leu Ala Leu  Gly Lys Ser Glu Glu  Glu Ala Leu 
    1025                 1030                 1035             


Lys Gln  Phe Lys Gln Lys Phe  Asp Glu Ala Leu Arg  Glu Ser Trp 
    1040                 1045                 1050             


Thr Thr  Lys Val Asn Trp Met  Ala His Thr Val Arg  Lys Asp Tyr 
    1055                 1060                 1065             


Arg Ser  
    1070 


<210>  9
<211>  1749
<212>  DNA
<213>  Homo sapiens

<400>  9
atgttgaatc caatgggaac tgttcaaaca aatccatata ctgaaaatgc aacagctttg       60

catgttaaat ttccagagaa taaaaaacaa ccttattatt accctccctt cgataagagt      120

cgaggtggaa aaaagtttct tcctgtattg aaagaaatct tggacaggga tcccttgtct      180

caactgtgtg aaaatgaaat ggatcttatt tggactttgc gacaagactg ccgagagatt      240

ttcccacaat cactgccaaa attactgctg tcaatcaagt ggaataaact tgaggatgtt      300

gctcagcttc aggcgctgct tcagatttgg cctaaactgc ccccccggga ggccctagag      360

cttctggatt tcaactatcc agaccagtac gttcgagaat atgctgtagg ctgcctgcga      420

cagatgagtg atgaagaact ttctcaatat cttttacaac tggtgcaagt gttaaaatat      480

gagccttttc ttgattgtgc cctctctaga ttcctattag aaagagcact tggtaatcgg      540

aggatagggc agtttctatt ttggcatctt aggtcagaag tgcacattcc tgctgtctca      600

gtacaatttg gtgtcatcct tgaagcatac tgccggggaa gtgtggggca catgaaagtg      660

ctttctaagc aggttgaagc actcaataag ttaaaaactt taaatagttt aatcaaactg      720

aatgccgtga agttaaacag agccaaaggg aaggaggcca tgcatacctg tttaaaacag      780

agtgcttacc gggaagccct ctctgacctg cagtcacccc tgaacccatg tgttatcctc      840

tcagaactct atgttgaaaa gtgcaaatac atggattcca aaatgaagcc tttgtggctg      900

gtatacaata acaaggtatt tggtgaggat tcagttggag tgatttttaa aaatggtgat      960

gatttacgac aggatatgtt gacactccaa atgttgcgct tgatggattt actctggaaa     1020

gaagctggtt tggatcttcg gatgttgcct tatggctgtt tagcaacagg agatcgctct     1080

ggcctcattg aagttgtgag cacctctgaa acaattgctg acattcagct gaacagtagc     1140

aatgtggctg ctgcagcagc cttcaacaaa gatgcccttc tgaactggct taaagaatac     1200

aactctgggg atgacctgga ccgagccatt gaggaattta cactgtcctg tgctggctac     1260

tgtgtagctt cttatgtcct tgggattggt gacagacata gtgacaacat catggtcaaa     1320

aaaactggcc agctcttcca cattgacttt ggacatattc ttggaaattt caaatctaag     1380

tttggcatta aaagggagcg agtgcctttt attcttacct atgatttcat ccatgtcatt     1440

caacaaggaa aaacaggaaa tacagaaaag tttggccggt tccgccagtg ttgtgaggat     1500

gcatatctga ttttacgacg gcatgggaat ctcttcatca ctctctttgc gctgatgttg     1560

actgcagggc ttcctgaact cacatcagtc aaagatatac agtatcttaa ggactctctt     1620

gcattaggga agagtgaaga agaagcactc aaacagttta agcaaaaatt tgatgaggcg     1680

ctcagggaaa gctggactac taaagtgaac tggatggccc acacagttcg gaaagactac     1740

agatcttaa                                                             1749


<210>  10
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Asn Pro Met Gly Thr Val Gln Thr Asn Pro Tyr Thr Glu Asn 
1               5                   10                  15      


Ala Thr Ala Leu His Val Lys Phe Pro Glu Asn Lys Lys Gln Pro Tyr 
            20                  25                  30          


Tyr Tyr Pro Pro Phe Asp Lys Ser Arg Gly Gly Lys Lys Phe Leu Pro 
        35                  40                  45              


Val Leu Lys Glu Ile Leu Asp Arg Asp Pro Leu Ser Gln Leu Cys Glu 
    50                  55                  60                  


Asn Glu Met Asp Leu Ile Trp Thr Leu Arg Gln Asp Cys Arg Glu Ile 
65                  70                  75                  80  


Phe Pro Gln Ser Leu Pro Lys Leu Leu Leu Ser Ile Lys Trp Asn Lys 
                85                  90                  95      


Leu Glu Asp Val Ala Gln Leu Gln Ala Leu Leu Gln Ile Trp Pro Lys 
            100                 105                 110         


Leu Pro Pro Arg Glu Ala Leu Glu Leu Leu Asp Phe Asn Tyr Pro Asp 
        115                 120                 125             


Gln Tyr Val Arg Glu Tyr Ala Val Gly Cys Leu Arg Gln Met Ser Asp 
    130                 135                 140                 


Glu Glu Leu Ser Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr 
145                 150                 155                 160 


Glu Pro Phe Leu Asp Cys Ala Leu Ser Arg Phe Leu Leu Glu Arg Ala 
                165                 170                 175     


Leu Gly Asn Arg Arg Ile Gly Gln Phe Leu Phe Trp His Leu Arg Ser 
            180                 185                 190         


Glu Val His Ile Pro Ala Val Ser Val Gln Phe Gly Val Ile Leu Glu 
        195                 200                 205             


Ala Tyr Cys Arg Gly Ser Val Gly His Met Lys Val Leu Ser Lys Gln 
    210                 215                 220                 


Val Glu Ala Leu Asn Lys Leu Lys Thr Leu Asn Ser Leu Ile Lys Leu 
225                 230                 235                 240 


Asn Ala Val Lys Leu Asn Arg Ala Lys Gly Lys Glu Ala Met His Thr 
                245                 250                 255     


Cys Leu Lys Gln Ser Ala Tyr Arg Glu Ala Leu Ser Asp Leu Gln Ser 
            260                 265                 270         


Pro Leu Asn Pro Cys Val Ile Leu Ser Glu Leu Tyr Val Glu Lys Cys 
        275                 280                 285             


Lys Tyr Met Asp Ser Lys Met Lys Pro Leu Trp Leu Val Tyr Asn Asn 
    290                 295                 300                 


Lys Val Phe Gly Glu Asp Ser Val Gly Val Ile Phe Lys Asn Gly Asp 
305                 310                 315                 320 


Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Met Leu Arg Leu Met Asp 
                325                 330                 335     


Leu Leu Trp Lys Glu Ala Gly Leu Asp Leu Arg Met Leu Pro Tyr Gly 
            340                 345                 350         


Cys Leu Ala Thr Gly Asp Arg Ser Gly Leu Ile Glu Val Val Ser Thr 
        355                 360                 365             


Ser Glu Thr Ile Ala Asp Ile Gln Leu Asn Ser Ser Asn Val Ala Ala 
    370                 375                 380                 


Ala Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Glu Tyr 
385                 390                 395                 400 


Asn Ser Gly Asp Asp Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser 
                405                 410                 415     


Cys Ala Gly Tyr Cys Val Ala Ser Tyr Val Leu Gly Ile Gly Asp Arg 
            420                 425                 430         


His Ser Asp Asn Ile Met Val Lys Lys Thr Gly Gln Leu Phe His Ile 
        435                 440                 445             


Asp Phe Gly His Ile Leu Gly Asn Phe Lys Ser Lys Phe Gly Ile Lys 
    450                 455                 460                 


Arg Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Ile His Val Ile 
465                 470                 475                 480 


Gln Gln Gly Lys Thr Gly Asn Thr Glu Lys Phe Gly Arg Phe Arg Gln 
                485                 490                 495     


Cys Cys Glu Asp Ala Tyr Leu Ile Leu Arg Arg His Gly Asn Leu Phe 
            500                 505                 510         


Ile Thr Leu Phe Ala Leu Met Leu Thr Ala Gly Leu Pro Glu Leu Thr 
        515                 520                 525             


Ser Val Lys Asp Ile Gln Tyr Leu Lys Asp Ser Leu Ala Leu Gly Lys 
    530                 535                 540                 


Ser Glu Glu Glu Ala Leu Lys Gln Phe Lys Gln Lys Phe Asp Glu Ala 
545                 550                 555                 560 


Leu Arg Glu Ser Trp Thr Thr Lys Val Asn Trp Met Ala His Thr Val 
                565                 570                 575     


Arg Lys Asp Tyr Arg Ser 
            580         


<210>  11
<211>  3195
<212>  DNA
<213>  Mus musculus

<400>  11
atgcctcctg ctatggcaga caaccttgac atctgggcag tggactcaca gattgcatcc       60

gatggcgcca tatccgtcga tttccttctg cccaccggga tttatatcca gttggaagta      120

cctcgggaag ctaccatttc ttatattaaa cagatgttat ggaagcaagt tcacaactac      180

ccgatgttta acctcctcat ggacattgac tcgtatatgt ttgcatgtgt gaatcaaact      240

gctgtatatg aggaactgga agacgaaaca cgaagacttt gtgatgtcag accttttctt      300

ccagttctca aactagtgac tagaagctgt gaccccgcag aaaaattgga ctcaaaaatt      360

ggggttctta taggaaaagg tcttcatgag tttgatgcct tgaaggatcc cgaagtgaat      420

gaatttagaa gaaaaatgcg caaattcagt gaggccaaga ttcagtctct ggtagggttg      480

tcttggatcg actggctaaa gcacacgtat ccgcctgagc acgagccgtc cgtcctggag      540

aacttggaag ataaacttta tggaggaaag ctggttgtgg ctgtgcactt tgaaaatagc      600

caggatgtat ttagttttca agtgtctccc aatttgaatc ctataaaaat aaatgaattg      660

gcaatccaga aacgcctcac tattcgtgga aaggaagatg aagctagccc ctgtgactat      720

gtgttacagg tcagtgggag agtggagtat gtgtttggcg atcatccact aattcagttc      780

cagtacatcc ggaattgtgt gatgaataga accctgcccc acttcatcct tgtggaatgt      840

tgtaagatca agaaaatgta tgaacaagaa atgattgcca tagaggctgc catcaaccga      900

aactcatcca accttcctct ccctttacca ccaaagaaaa cgcgagttat ttctcatatc      960

tgggacaaca acaacccttt ccaaattacc ttggttaaag gaaataagct taatacagaa     1020

gaaactgtga aagttcatgt ccgagctggg ctttttcacg gaaccgagct cctgtgtaaa     1080

accgtcgtaa gctcagagat atcaggaaag aacgaccata tttggaatga acaactggaa     1140

tttgatatta atatttgtga cttaccaaga atggctcgat tatgttttgc tgtttatgca     1200

gttttggata aagtaaaaac gaagaaatca acaaagacta ttaatccctc taagtatcag     1260

accatcagga aagccgggaa agtgcattat cctgtcgcat gggtaaatac catggttttt     1320

gacttcaaag gacagctgag gtctggagac gtcatattgc atagctggtc ttcgtttcct     1380

gatgagctgg aagaaatgct gaatcccatg gggactgtgc agacgaaccc atatgctgag     1440

aacgccaccg ccttgcacat tacgttccca gagaataaga agcagccgtg ttattatccc     1500

cccttcgata agatcattga gaaggcagct gagcttgcca gcggagacag tgctaatgtg     1560

tcaagtcgtg gtggaaaaaa atttcttgct gtgctgaaag aaatcttgga cagggacccc     1620

ctgtctcagc tgtgtgagaa cgaaatggac cttatttgga ctctacggca agactgccga     1680

gaaaatttcc ctcagtcact gccaaaacta ctcttgtcaa tcaagtggaa taaacttgaa     1740

gatgttgctc agcttcaggc gctcctgcag atatggccca aactgccccc cagggaagcc     1800

ctggaactcc tggatttcaa ctatccagac cagtatgtcc gggaatacgc tgtaggctgc     1860

cttcgacaga tgagtgatga agaactctct cagtatcttt tacaattggt gcaagttttg     1920

aaatatgagc cttttctcga ttgtgccctc tccagattcc tattagaaag agcacttgat     1980

aatcggagga ttgggcagtt tctgttttgg catcttaggt cagaggtgca cactcctgct     2040

gtgtccgtac agtttggtgt catcctggaa gcatactgtc gaggaagcgt ggggcacatg     2100

aaagtgcttt ccaaacaggt ggaagcactc aataagttaa aaactttaaa tagcttaatc     2160

aaactgaatg cggtgaagct gagcagagct aagggaaagg aggccatgca cacgtgcctg     2220

aaacagagtg cttaccggga ggcgctctct gacctgcagt cgccgctgaa cccctgcgtc     2280

atcctctcag agctctatgt tgaaaagtgc aaatacatgg actccaagat gaagcccctg     2340

tggctggtct acagcagcag agcctttgga gaggactcgg ttggagtgat ctttaaaaat     2400

ggtgacgatt tgcggcagga catgctgacg ctgcagatgt tgcgcctgat ggatctgctt     2460

tggaaagaag ctggcttgga cctgcggatg ctcccctatg gctgcttagc aacaggagat     2520

cgctctggcc tcattgaggt tgtgagcacc tctgagacaa tcgctgacat tcagctgaac     2580

agtagtaacg tggctgccac ggcagccttc aacaaagacg cactcctgaa ctggctcaag     2640

gagtacaact ctggggatga cctggaccga gcgattgagg agtttacctt gtcctgtgct     2700

ggctactgtg tagcctctta tgtcctcggc attggtgaca ggcacagtga caacatcatg     2760

gtgaagaaaa ccggccagct cttccacata gattttgggc atattcttgg aaatttcaaa     2820

tctaaatttg gcattaaaag ggagcgagta ccttttattc ttacttatga cttcattcat     2880

gtcattcaac aaggaaaaac gggaaacact gaaaaatttg gcagattccg ccagtgctgt     2940

gaagatgcgt atctgatttt acggcggcat gggaatctct tcatcaccct gtttgccctg     3000

atgttgactg cagggctgcc tgagctcaca tcggtcaaag atatacagta tcttaaggac     3060

tcgcttgcct tagggaagag cgaggaggaa gcactgaagc agttcaagca gaagtttgac     3120

gaggccctca gggaaagctg gactactaaa gtgaactgga tggctcacac agtacggaaa     3180

gactacaggt cctag                                                      3195


<210>  12
<211>  1064
<212>  PRT
<213>  Mus musculus

<400>  12

Met Pro Pro Ala Met Ala Asp Asn Leu Asp Ile Trp Ala Val Asp Ser 
1               5                   10                  15      


Gln Ile Ala Ser Asp Gly Ala Ile Ser Val Asp Phe Leu Leu Pro Thr 
            20                  25                  30          


Gly Ile Tyr Ile Gln Leu Glu Val Pro Arg Glu Ala Thr Ile Ser Tyr 
        35                  40                  45              


Ile Lys Gln Met Leu Trp Lys Gln Val His Asn Tyr Pro Met Phe Asn 
    50                  55                  60                  


Leu Leu Met Asp Ile Asp Ser Tyr Met Phe Ala Cys Val Asn Gln Thr 
65                  70                  75                  80  


Ala Val Tyr Glu Glu Leu Glu Asp Glu Thr Arg Arg Leu Cys Asp Val 
                85                  90                  95      


Arg Pro Phe Leu Pro Val Leu Lys Leu Val Thr Arg Ser Cys Asp Pro 
            100                 105                 110         


Ala Glu Lys Leu Asp Ser Lys Ile Gly Val Leu Ile Gly Lys Gly Leu 
        115                 120                 125             


His Glu Phe Asp Ala Leu Lys Asp Pro Glu Val Asn Glu Phe Arg Arg 
    130                 135                 140                 


Lys Met Arg Lys Phe Ser Glu Ala Lys Ile Gln Ser Leu Val Gly Leu 
145                 150                 155                 160 


Ser Trp Ile Asp Trp Leu Lys His Thr Tyr Pro Pro Glu His Glu Pro 
                165                 170                 175     


Ser Val Leu Glu Asn Leu Glu Asp Lys Leu Tyr Gly Gly Lys Leu Val 
            180                 185                 190         


Val Ala Val His Phe Glu Asn Ser Gln Asp Val Phe Ser Phe Gln Val 
        195                 200                 205             


Ser Pro Asn Leu Asn Pro Ile Lys Ile Asn Glu Leu Ala Ile Gln Lys 
    210                 215                 220                 


Arg Leu Thr Ile Arg Gly Lys Glu Asp Glu Ala Ser Pro Cys Asp Tyr 
225                 230                 235                 240 


Val Leu Gln Val Ser Gly Arg Val Glu Tyr Val Phe Gly Asp His Pro 
                245                 250                 255     


Leu Ile Gln Phe Gln Tyr Ile Arg Asn Cys Val Met Asn Arg Thr Leu 
            260                 265                 270         


Pro His Phe Ile Leu Val Glu Cys Cys Lys Ile Lys Lys Met Tyr Glu 
        275                 280                 285             


Gln Glu Met Ile Ala Ile Glu Ala Ala Ile Asn Arg Asn Ser Ser Asn 
    290                 295                 300                 


Leu Pro Leu Pro Leu Pro Pro Lys Lys Thr Arg Val Ile Ser His Ile 
305                 310                 315                 320 


Trp Asp Asn Asn Asn Pro Phe Gln Ile Thr Leu Val Lys Gly Asn Lys 
                325                 330                 335     


Leu Asn Thr Glu Glu Thr Val Lys Val His Val Arg Ala Gly Leu Phe 
            340                 345                 350         


His Gly Thr Glu Leu Leu Cys Lys Thr Val Val Ser Ser Glu Ile Ser 
        355                 360                 365             


Gly Lys Asn Asp His Ile Trp Asn Glu Gln Leu Glu Phe Asp Ile Asn 
    370                 375                 380                 


Ile Cys Asp Leu Pro Arg Met Ala Arg Leu Cys Phe Ala Val Tyr Ala 
385                 390                 395                 400 


Val Leu Asp Lys Val Lys Thr Lys Lys Ser Thr Lys Thr Ile Asn Pro 
                405                 410                 415     


Ser Lys Tyr Gln Thr Ile Arg Lys Ala Gly Lys Val His Tyr Pro Val 
            420                 425                 430         


Ala Trp Val Asn Thr Met Val Phe Asp Phe Lys Gly Gln Leu Arg Ser 
        435                 440                 445             


Gly Asp Val Ile Leu His Ser Trp Ser Ser Phe Pro Asp Glu Leu Glu 
    450                 455                 460                 


Glu Met Leu Asn Pro Met Gly Thr Val Gln Thr Asn Pro Tyr Ala Glu 
465                 470                 475                 480 


Asn Ala Thr Ala Leu His Ile Thr Phe Pro Glu Asn Lys Lys Gln Pro 
                485                 490                 495     


Cys Tyr Tyr Pro Pro Phe Asp Lys Ile Ile Glu Lys Ala Ala Glu Leu 
            500                 505                 510         


Ala Ser Gly Asp Ser Ala Asn Val Ser Ser Arg Gly Gly Lys Lys Phe 
        515                 520                 525             


Leu Ala Val Leu Lys Glu Ile Leu Asp Arg Asp Pro Leu Ser Gln Leu 
    530                 535                 540                 


Cys Glu Asn Glu Met Asp Leu Ile Trp Thr Leu Arg Gln Asp Cys Arg 
545                 550                 555                 560 


Glu Asn Phe Pro Gln Ser Leu Pro Lys Leu Leu Leu Ser Ile Lys Trp 
                565                 570                 575     


Asn Lys Leu Glu Asp Val Ala Gln Leu Gln Ala Leu Leu Gln Ile Trp 
            580                 585                 590         


Pro Lys Leu Pro Pro Arg Glu Ala Leu Glu Leu Leu Asp Phe Asn Tyr 
        595                 600                 605             


Pro Asp Gln Tyr Val Arg Glu Tyr Ala Val Gly Cys Leu Arg Gln Met 
    610                 615                 620                 


Ser Asp Glu Glu Leu Ser Gln Tyr Leu Leu Gln Leu Val Gln Val Leu 
625                 630                 635                 640 


Lys Tyr Glu Pro Phe Leu Asp Cys Ala Leu Ser Arg Phe Leu Leu Glu 
                645                 650                 655     


Arg Ala Leu Asp Asn Arg Arg Ile Gly Gln Phe Leu Phe Trp His Leu 
            660                 665                 670         


Arg Ser Glu Val His Thr Pro Ala Val Ser Val Gln Phe Gly Val Ile 
        675                 680                 685             


Leu Glu Ala Tyr Cys Arg Gly Ser Val Gly His Met Lys Val Leu Ser 
    690                 695                 700                 


Lys Gln Val Glu Ala Leu Asn Lys Leu Lys Thr Leu Asn Ser Leu Ile 
705                 710                 715                 720 


Lys Leu Asn Ala Val Lys Leu Ser Arg Ala Lys Gly Lys Glu Ala Met 
                725                 730                 735     


His Thr Cys Leu Lys Gln Ser Ala Tyr Arg Glu Ala Leu Ser Asp Leu 
            740                 745                 750         


Gln Ser Pro Leu Asn Pro Cys Val Ile Leu Ser Glu Leu Tyr Val Glu 
        755                 760                 765             


Lys Cys Lys Tyr Met Asp Ser Lys Met Lys Pro Leu Trp Leu Val Tyr 
    770                 775                 780                 


Ser Ser Arg Ala Phe Gly Glu Asp Ser Val Gly Val Ile Phe Lys Asn 
785                 790                 795                 800 


Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Met Leu Arg Leu 
                805                 810                 815     


Met Asp Leu Leu Trp Lys Glu Ala Gly Leu Asp Leu Arg Met Leu Pro 
            820                 825                 830         


Tyr Gly Cys Leu Ala Thr Gly Asp Arg Ser Gly Leu Ile Glu Val Val 
        835                 840                 845             


Ser Thr Ser Glu Thr Ile Ala Asp Ile Gln Leu Asn Ser Ser Asn Val 
    850                 855                 860                 


Ala Ala Thr Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys 
865                 870                 875                 880 


Glu Tyr Asn Ser Gly Asp Asp Leu Asp Arg Ala Ile Glu Glu Phe Thr 
                885                 890                 895     


Leu Ser Cys Ala Gly Tyr Cys Val Ala Ser Tyr Val Leu Gly Ile Gly 
            900                 905                 910         


Asp Arg His Ser Asp Asn Ile Met Val Lys Lys Thr Gly Gln Leu Phe 
        915                 920                 925             


His Ile Asp Phe Gly His Ile Leu Gly Asn Phe Lys Ser Lys Phe Gly 
    930                 935                 940                 


Ile Lys Arg Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Ile His 
945                 950                 955                 960 


Val Ile Gln Gln Gly Lys Thr Gly Asn Thr Glu Lys Phe Gly Arg Phe 
                965                 970                 975     


Arg Gln Cys Cys Glu Asp Ala Tyr Leu Ile Leu Arg Arg His Gly Asn 
            980                 985                 990         


Leu Phe Ile Thr Leu Phe Ala Leu  Met Leu Thr Ala Gly  Leu Pro Glu 
        995                 1000                 1005             


Leu Thr  Ser Val Lys Asp Ile  Gln Tyr Leu Lys Asp  Ser Leu Ala 
    1010                 1015                 1020             


Leu Gly  Lys Ser Glu Glu Glu  Ala Leu Lys Gln Phe  Lys Gln Lys 
    1025                 1030                 1035             


Phe Asp  Glu Ala Leu Arg Glu  Ser Trp Thr Thr Lys  Val Asn Trp 
    1040                 1045                 1050             


Met Ala  His Thr Val Arg Lys  Asp Tyr Arg Ser 
    1055                 1060                 


<210>  13
<211>  3309
<212>  DNA
<213>  Homo sapiens

<400>  13
atggagctgg agaactataa acagcccgtg gtgctgagag aggacaactg ccgaaggcgc       60

cggaggatga agccgcgcag tgctgcggcc agcctgtcct ccatggagct catccccatc      120

gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc ccgaaacggc gctgctgcac      180

gtggccggcc acggcaacgt ggagcagatg aaggcccagg tgtggctgcg agcgctggag      240

accagcgtgg cggcggactt ctaccaccgg ctgggaccgc atcacttcct cctgctctat      300

cagaagaagg ggcagtggta cgagatctac gacaagtacc aggtggtgca gactctggac      360

tgcctgcgct actggaaggc cacgcaccgg agcccgggcc agatccacct ggtgcagcgg      420

cacccgccct ccgaggagtc ccaagccttc cagcggcagc tcacggcgct gattggctat      480

gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg agttcacgcg ccgtggcttg      540

gtgaccccgc gcatggcgga ggtggccagc cgcgacccca agctctacgc catgcacccg      600

tgggtgacgt ccaagcccct cccggagtac ctgtggaaga agattgccaa caactgcatc      660

ttcatcgtca ttcaccgcag caccaccagc cagaccatta aggtctcacc cgacgacacc      720

cccggcgcca tcctgcagag cttcttcacc aagatggcca agaagaaatc tctgatggat      780

attcccgaaa gccaaagcga acaggatttt gtgctgcgcg tctgtggccg ggatgagtac      840

ctggtgggcg aaacgcccat caaaaacttc cagtgggtga ggcactgcct caagaacgga      900

gaagagattc acgtggtact ggacacgcct ccagacccgg ccctagacga ggtgaggaag      960

gaagagtggc cactggtgga tgactgcacg ggagtcaccg gctaccatga gcagcttacc     1020

atccacggca aggaccacga gagtgtgttc accgtgtccc tgtgggactg cgaccgcaag     1080

ttcagggtca agatcagagg cattgatatc cccgtcctgc ctcggaacac cgacctcaca     1140

gtttttgtag aggcaaacat ccagcatggg caacaagtcc tttgccaaag gagaaccagc     1200

cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc ttgagttcag tatcaaaatc     1260

aaagacttgc ccaaaggggc tctactgaac ctccagatct actgcggtaa agctccagca     1320

ctgtccagca aggcctctgc agagtccccc agttctgagt ccaagggcaa agttcagctt     1380

ctctattatg tgaacctgct gctgatagac caccgtttcc tcctgcgccg tggagaatac     1440

gtcctccaca tgtggcagat atctgggaag ggagaagacc aaggaagctt caatgctgac     1500

aaactcacgt ctgcaactaa cccagacaag gagaactcaa tgtccatctc cattcttctg     1560

gacaattact gccacccgat agccctgcct aagcatcagc ccacccctga cccggaaggg     1620

gaccgggttc gagcagaaat gcccaaccag cttcgcaagc aattggaggc gatcatagcc     1680

actgatccac ttaaccctct cacagcagag gacaaagaat tgctctggca ttttagatac     1740

gaaagcctta agcacccaaa agcatatcct aagctattta gttcagtgaa atggggacag     1800

caagaaattg tggccaaaac ataccaattg ttggccagaa gggaagtctg ggatcaaagt     1860

gctttggatg ttgggttaac aatgcagctc ctggactgca acttctcaga tgaaaatgta     1920

agagccattg cagttcagaa actggagagc ttggaggacg atgatgttct gcattacctt     1980

ctacaattgg tccaggctgt gaaatttgaa ccataccatg atagcgccct tgccagattt     2040

ctgctgaagc gtggtttaag aaacaaaaga attggtcact ttttgttttg gttcttgaga     2100

agtgagatag cccagtccag acactatcag cagaggttcg ctgtgattct ggaagcctat     2160

ctgaggggct gtggcacagc catgctgcac gactttaccc aacaagtcca agtaatcgag     2220

atgttacaaa aagtcaccct tgatattaaa tcgctctctg ctgaaaagta tgacgtcagt     2280

tcccaagtta tttcacaact taaacaaaag cttgaaaacc tgcagaattc tcaactcccc     2340

gaaagcttta gagttccata tgatcctgga ctgaaagcag gagcgctggc aattgaaaaa     2400

tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg agtttaaatg tgccgatcct     2460

acagccctat caaatgaaac aattggaatt atctttaaac atggtgatga tctgcgccaa     2520

gacatgctta ttttacagat tctacgaatc atggagtcta tttgggagac tgaatctttg     2580

gatctatgcc tcctgccata tggttgcatt tcaactggtg acaaaatagg aatgatcgag     2640

attgtgaaag acgccacgac aattgccaaa attcagcaaa gcacagtggg caacacggga     2700

gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa aatcccctac tgaagaaaag     2760

tttcaggcag cagtggagag atttgtttat tcctgtgcag gctactgtgt ggcaaccttt     2820

gttcttggaa taggcgacag acacaatgac aatattatga tcaccgagac aggaaaccta     2880

tttcatattg acttcgggca cattcttggg aattacaaaa gtttcctggg cattaataaa     2940

gagagagtgc catttgtgct aacccctgac ttcctctttg tgatgggaac ttctggaaag     3000

aagacaagcc cacacttcca gaaatttcag gacatctgtg ttaaggctta tctagccctt     3060

cgtcatcaca caaacctact gatcatcctg ttctccatga tgctgatgac aggaatgccc     3120

cagttaacaa gcaaagaaga cattgaatat atccgggatg ccctcacagt ggggaaaaat     3180

gaggaggatg ctaaaaagta ttttcttgat cagatcgaag tttgcagaga caaaggatgg     3240

actgtgcagt ttaattggtt tctacatctt gttcttggca tcaaacaagg agagaaacat     3300

tcagcctaa                                                             3309


<210>  14
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Leu Glu Asn Tyr Lys Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Cys Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Ala Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Lys Cys Lys Ser Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Asp Phe Tyr His Arg Leu Gly Pro His His Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Lys 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu Arg Tyr Trp Lys Ala Thr 
        115                 120                 125             


His Arg Ser Pro Gly Gln Ile His Leu Val Gln Arg His Pro Pro Ser 
    130                 135                 140                 


Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg Asp 
            180                 185                 190         


Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile His 
    290                 295                 300                 


Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln Val 
                725                 730                 735     


Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Thr Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Ile Cys Val Lys  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Asn  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  15
<211>  3309
<212>  DNA
<213>  Homo sapiens

<400>  15
atggagctgg agaactataa acagcccgtg gtgctgagag aggacaactg ccgaaggcgc       60

cggaggatga agccgcgcag tgctgcggcc agcctgtcct ccatggagct catccccatc      120

gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc ccgaaacggc gctgctgcac      180

gtggccggcc acggcaacgt ggagcagatg aaggcccagg tgtggctgcg agcgctggag      240

accagcgtgg cggcggactt ctaccaccgg ctgggaccgc atcacttcct cctgctctat      300

cagaagaagg ggcagtggta cgagatctac gacaagtacc aggtggtgca gactctggac      360

tgcctgcgct actggaaggc cacgcaccgg agcccgggcc agatccacct ggtgcagcgg      420

cacccgccct ccgaggagtc ccaagccttc cagcggcagc tcacggcgct gattggctat      480

gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg agttcacgcg ccgtggcttg      540

gtgaccccgc gcatggcgga ggtggccagc cgcgacccca agctctacgc catgcacccg      600

tgggtgacgt ccaagcccct cccggagtac ctgtggaaga agattgccaa caactgcatc      660

ttcatcgtca ttcaccgcag caccaccagc cagaccatta aggtctcacc cgacgacacc      720

cccggcgcca tcctgcagag cttcttcacc aagatggcca agaagaaatc tctgatggat      780

attcccgaaa gccaaagcga acaggatttt gtgctgcgcg tctgtggccg ggatgagtac      840

ctggtgggcg aaacgcccat caaaaacttc cagtgggtga ggcactgcct caagaacgga      900

gaagagattc acgtggtact ggacacgcct ccagacccgg ccctagacga ggtgaggaag      960

gaagagtggc cactggtgga tgactgcacg ggagtcaccg gctaccatga gcagcttacc     1020

atccacggca aggaccacga gagtgtgttc accgtgtccc tgtgggactg cgaccgcaag     1080

ttcagggtca agatcagagg cattgatatc cccgtcctgc ctcggaacac cgacctcaca     1140

gtttttgtag aggcaaacat ccagcatggg caacaagtcc tttgccaaag gagaaccagc     1200

cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc ttgagttcag tatcaaaatc     1260

aaagacttgc ccaaaggggc tctactgaac ctccagatct actgcggtaa agctccagca     1320

ctgtccagca aggcctctgc agagtccccc agttctgagt ccaagggcaa agttcagctt     1380

ctctattatg tgaacctgct gctgatagac caccgtttcc tcctgcgccg tggagaatac     1440

gtcctccaca tgtggcagat atctgggaag ggagaagacc aaggaagctt caatgctgac     1500

aaactcacgt ctgcaactaa cccagacaag gagaactcaa tgtccatctc cattcttctg     1560

gacaattact gccacccgat agccctgcct aagcatcagc ccacccctga cccggaaggg     1620

gaccgggttc gagcagaaat gcccaaccag cttcgcaagc aattggaggc gatcatagcc     1680

actgatccac ttaaccctct cacagcagag gacaaagaat tgctctggca ttttagatac     1740

gaaagcctta agcacccaaa agcatatcct aagctattta gttcagtgaa atggggacag     1800

caagaaattg tggccaaaac ataccaattg ttggccagaa gggaagtctg ggatcaaagt     1860

gctttggatg ttgggttaac aatgcagctc ctggactgca acttctcaga tgaaaatgta     1920

agagccattg cagttcagaa actggagagc ttggaggacg atgatgttct gcattacctt     1980

ctacaattgg tccaggctgt gaaatttgaa ccataccatg atagcgccct tgccagattt     2040

ctgctgaagc gtggtttaag aaacaaaaga attggtcact ttttgttttg gttcttgaga     2100

agtgagatag cccagtccag acactatcag cagaggttcg ctgtgattct ggaagcctat     2160

ctgaggggct gtggcacagc catgctgcac gactttaccc aacaagtcca agtaatcgag     2220

atgttacaaa aagtcaccct tgatattaaa tcgctctctg ctgaaaagta tgacgtcagt     2280

tcccaagtta tttcacaact taaacaaaag cttgaaaacc tgcagaattc tcaactcccc     2340

gaaagcttta gagttccata tgatcctgga ctgaaagcag gagcgctggc aattgaaaaa     2400

tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg agtttaaatg tgccgatcct     2460

acagccctat caaatgaaac aattggaatt atctttaaac atggtgatga tctgcgccaa     2520

gacatgctta ttttacagat tctacgaatc atggagtcta tttgggagac tgaatctttg     2580

gatctatgcc tcctgccata tggttgcatt tcaactggtg acaaaatagg aatgatcgag     2640

attgtgaaag acgccacgac aattgccaaa attcagcaaa gcacagtggg caacacggga     2700

gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa aatcccctac tgaagaaaag     2760

tttcaggcag cagtggagag atttgtttat tcctgtgcag gctactgtgt ggcaaccttt     2820

gttcttggaa taggcgacag acacaatgac aatattatga tcaccgagac aggaaaccta     2880

tttcatattg acttcgggca cattcttggg aattacaaaa gtttcctggg cattaataaa     2940

gagagagtgc catttgtgct aacccctgac ttcctctttg tgatgggaac ttctggaaag     3000

aagacaagcc cacacttcca gaaatttcag gacatctgtg ttaaggctta tctagccctt     3060

cgtcatcaca caaacctact gatcatcctg ttctccatga tgctgatgac aggaatgccc     3120

cagttaacaa gcaaagaaga cattgaatat atccgggatg ccctcacagt ggggaaaaat     3180

gaggaggatg ctaaaaagta ttttcttgat cagatcgaag tttgcagaga caaaggatgg     3240

actgtgcagt ttaattggtt tctacatctt gttcttggca tcaaacaagg agagaaacat     3300

tcagcctaa                                                             3309


<210>  16
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Leu Glu Asn Tyr Lys Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Cys Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Ala Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Lys Cys Lys Ser Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Asp Phe Tyr His Arg Leu Gly Pro His His Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Lys 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu Arg Tyr Trp Lys Ala Thr 
        115                 120                 125             


His Arg Ser Pro Gly Gln Ile His Leu Val Gln Arg His Pro Pro Ser 
    130                 135                 140                 


Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg Asp 
            180                 185                 190         


Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile His 
    290                 295                 300                 


Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln Val 
                725                 730                 735     


Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Thr Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Ile Cys Val Lys  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Asn  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  17
<211>  3309
<212>  DNA
<213>  Homo sapiens

<400>  17
atggagctgg agaactataa acagcccgtg gtgctgagag aggacaactg ccgaaggcgc       60

cggaggatga agccgcgcag tgctgcggcc agcctgtcct ccatggagct catccccatc      120

gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc ccgaaacggc gctgctgcac      180

gtggccggcc acggcaacgt ggagcagatg aaggcccagg tgtggctgcg agcgctggag      240

accagcgtgg cggcggactt ctaccaccgg ctgggaccgc atcacttcct cctgctctat      300

cagaagaagg ggcagtggta cgagatctac gacaagtacc aggtggtgca gactctggac      360

tgcctgcgct actggaaggc cacgcaccgg agcccgggcc agatccacct ggtgcagcgg      420

cacccgccct ccgaggagtc ccaagccttc cagcggcagc tcacggcgct gattggctat      480

gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg agttcacgcg ccgtggcttg      540

gtgaccccgc gcatggcgga ggtggccagc cgcgacccca agctctacgc catgcacccg      600

tgggtgacgt ccaagcccct cccggagtac ctgtggaaga agattgccaa caactgcatc      660

ttcatcgtca ttcaccgcag caccaccagc cagaccatta aggtctcacc cgacgacacc      720

cccggcgcca tcctgcagag cttcttcacc aagatggcca agaagaaatc tctgatggat      780

attcccgaaa gccaaagcga acaggatttt gtgctgcgcg tctgtggccg ggatgagtac      840

ctggtgggcg aaacgcccat caaaaacttc cagtgggtga ggcactgcct caagaacgga      900

gaagagattc acgtggtact ggacacgcct ccagacccgg ccctagacga ggtgaggaag      960

gaagagtggc cactggtgga tgactgcacg ggagtcaccg gctaccatga gcagcttacc     1020

atccacggca aggaccacga gagtgtgttc accgtgtccc tgtgggactg cgaccgcaag     1080

ttcagggtca agatcagagg cattgatatc cccgtcctgc ctcggaacac cgacctcaca     1140

gtttttgtag aggcaaacat ccagcatggg caacaagtcc tttgccaaag gagaaccagc     1200

cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc ttgagttcag tatcaaaatc     1260

aaagacttgc ccaaaggggc tctactgaac ctccagatct actgcggtaa agctccagca     1320

ctgtccagca aggcctctgc agagtccccc agttctgagt ccaagggcaa agttcagctt     1380

ctctattatg tgaacctgct gctgatagac caccgtttcc tcctgcgccg tggagaatac     1440

gtcctccaca tgtggcagat atctgggaag ggagaagacc aaggaagctt caatgctgac     1500

aaactcacgt ctgcaactaa cccagacaag gagaactcaa tgtccatctc cattcttctg     1560

gacaattact gccacccgat agccctgcct aagcatcagc ccacccctga cccggaaggg     1620

gaccgggttc gagcagaaat gcccaaccag cttcgcaagc aattggaggc gatcatagcc     1680

actgatccac ttaaccctct cacagcagag gacaaagaat tgctctggca ttttagatac     1740

gaaagcctta agcacccaaa agcatatcct aagctattta gttcagtgaa atggggacag     1800

caagaaattg tggccaaaac ataccaattg ttggccagaa gggaagtctg ggatcaaagt     1860

gctttggatg ttgggttaac aatgcagctc ctggactgca acttctcaga tgaaaatgta     1920

agagccattg cagttcagaa actggagagc ttggaggacg atgatgttct gcattacctt     1980

ctacaattgg tccaggctgt gaaatttgaa ccataccatg atagcgccct tgccagattt     2040

ctgctgaagc gtggtttaag aaacaaaaga attggtcact ttttgttttg gttcttgaga     2100

agtgagatag cccagtccag acactatcag cagaggttcg ctgtgattct ggaagcctat     2160

ctgaggggct gtggcacagc catgctgcac gactttaccc aacaagtcca agtaatcgag     2220

atgttacaaa aagtcaccct tgatattaaa tcgctctctg ctgaaaagta tgacgtcagt     2280

tcccaagtta tttcacaact taaacaaaag cttgaaaacc tgcagaattc tcaactcccc     2340

gaaagcttta gagttccata tgatcctgga ctgaaagcag gagcgctggc aattgaaaaa     2400

tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg agtttaaatg tgccgatcct     2460

acagccctat caaatgaaac aattggaatt atctttaaac atggtgatga tctgcgccaa     2520

gacatgctta ttttacagat tctacgaatc atggagtcta tttgggagac tgaatctttg     2580

gatctatgcc tcctgccata tggttgcatt tcaactggtg acaaaatagg aatgatcgag     2640

attgtgaaag acgccacgac aattgccaaa attcagcaaa gcacagtggg caacacggga     2700

gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa aatcccctac tgaagaaaag     2760

tttcaggcag cagtggagag atttgtttat tcctgtgcag gctactgtgt ggcaaccttt     2820

gttcttggaa taggcgacag acacaatgac aatattatga tcaccgagac aggaaaccta     2880

tttcatattg acttcgggca cattcttggg aattacaaaa gtttcctggg cattaataaa     2940

gagagagtgc catttgtgct aacccctgac ttcctctttg tgatgggaac ttctggaaag     3000

aagacaagcc cacacttcca gaaatttcag gacatctgtg ttaaggctta tctagccctt     3060

cgtcatcaca caaacctact gatcatcctg ttctccatga tgctgatgac aggaatgccc     3120

cagttaacaa gcaaagaaga cattgaatat atccgggatg ccctcacagt ggggaaaaat     3180

gaggaggatg ctaaaaagta ttttcttgat cagatcgaag tttgcagaga caaaggatgg     3240

actgtgcagt ttaattggtt tctacatctt gttcttggca tcaaacaagg agagaaacat     3300

tcagcctaa                                                             3309


<210>  18
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Leu Glu Asn Tyr Lys Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Cys Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Ala Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Lys Cys Lys Ser Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Asp Phe Tyr His Arg Leu Gly Pro His His Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Lys 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu Arg Tyr Trp Lys Ala Thr 
        115                 120                 125             


His Arg Ser Pro Gly Gln Ile His Leu Val Gln Arg His Pro Pro Ser 
    130                 135                 140                 


Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg Asp 
            180                 185                 190         


Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile His 
    290                 295                 300                 


Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln Val 
                725                 730                 735     


Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Thr Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Ile Cys Val Lys  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Asn  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  19
<211>  3309
<212>  DNA
<213>  Mus musculus

<400>  19
atggagctgg agaactatga acaaccggtg gttctaagag aggacaacct ccgccggcgc       60

cggaggatga agccacgcag cgcagcaggc agcctgtctt ccatggagct catccccatt      120

gagttcgtac tgcccaccag ccagcgcatc agcaagactc cagaaacagc gctgctgcat      180

gtggctggcc atggcaatgt ggaacagatg aaagctcagg tgtggctgcg cgcactggag      240

accagtgtgg ctgcggagtt ctaccaccga ttgggcccgg accaattcct cctgctctac      300

cagaagaaag gacaatggta tgagatctat gacaggtacc aagtggtgca gaccctagac      360

tgcctgcatt actggaagtt gatgcacaag agccctggcc agatccacgt ggtacagcga      420

cacgtacctt ctgaggagac cttggctttc cagaagcagc tcacctccct gattggctat      480

gacgtcactg acatcagcaa tgtgcacgat gatgagctag agttcactcg ccgccgtctg      540

gttacgcccc gcatggctga agtggctggc cgggatgcca aactctatgc tatgcaccct      600

tgggtaacgt ccaaacctct cccagactac ctgtcaaaaa agattgccaa caactgcatc      660

ttcatcgtca tccaccgcgg taccaccagc caaaccatca aggtctccgc agatgatact      720

cctggtacca tcctccagag cttcttcacc aagatggcca agaagaagtc cctaatgaat      780

atctcagaaa gtcaaagtga gcaggatttt gtattgcggg tttgtggccg cgatgagtac      840

ctggtgggtg aaacacccct caaaaatttc cagtgggtga ggcagtgcct caagaacgga      900

gatgaaatac acctggtgct cgacacgcct ccagacccag cccttgatga ggtgaggaag      960

gaagaatggc cgctggtgga tgactgcact ggagtcaccg gctaccacga gcagctgacc     1020

atccatggca aggaccacga gagtgtgttc acagtgtctt tgtgggactg cgaccgaaag     1080

ttcagggtca agatcagagg cattgatatc cctgtcctgc ctcggaacac cgacctcact     1140

gtgtttgtgg aagcgaacat ccagcacggg caacaagtcc tctgccaaag gagaaccagc     1200

cctaagccct tcgcagaaga ggtactctgg aatgtgtggc tggagtttgg catcaaaatc     1260

aaagacttgc ccaaaggggc tctattgaac ctacagatct actgctgcaa aaccccatca     1320

ctgtccagca aggcttctgc agagactcca ggctccgagt ccaagggcaa agcccagctt     1380

ctctattacg tgaacttgct gttaatagac caccgtttcc tcctccgcca cggggactat     1440

gtgctccaca tgtggcagat atctggcaag gcagaggagc agggcagctt caatgctgac     1500

aagctcacat ccgcaaccaa tcctgacaag gagaactcaa tgtccatttc catcctgctg     1560

gacaattact gtcaccccat agctttgcct aagcaccggc ccacccctga cccagaggga     1620

gacagggttc gggctgaaat gcccaatcag cttcgaaagc aattggaggc gatcatagcc     1680

acagatccac ttaaccccct cacagcagag gacaaagaat tgctctggca ttttcgatat     1740

gaaagcctga agcatccgaa ggcttaccct aagctattca gctcagtgaa atgggggcag     1800

caagaaattg ttgccaaaac gtaccagctg ttagccagaa gggagatctg ggatcaaagt     1860

gctttggacg ttggcttaac catgcagctc ctggactgca acttttcaga cgagaatgtc     1920

cgggccattg cagttcagaa actggagagc ttagaggacg atgacgtttt acattacctt     1980

ctccagctgg tacaggctgt gaaatttgaa ccgtaccacg acagtgcgct ggccagattc     2040

ctgctgaagc gtggcttgag gaacaaaaga atcggtcact tcttgttctg gttcctgcga     2100

agtgagatcg cacagtccag acactatcag cagaggttcg ctgtgatcct ggaggcgtac     2160

ctgcgaggct gtggcacagc catgttgcag gacttcacac agcaggtcca tgtgattgag     2220

atgttacaga aagtcaccat tgatattaaa tcgctctcgg cagagaagta tgacgtcagt     2280

tcccaagtta tttcacagct taagcaaaag cttgaaagcc ttcagaactc caatctcccc     2340

gagagcttta gagttcccta tgatcctgga ctaaaagccg gtaccctggt gatcgagaaa     2400

tgcaaagtga tggcctccaa gaagaagccc ctgtggcttg agtttaagtg tgctgatccc     2460

acagtcctat ccaacgaaac cattggaatc atctttaaac atggtgatga tctgcgccaa     2520

gacatgttga tcttgcagat tctacgcatc atggagtcca tttgggagac tgaatctctg     2580

gacctgtgcc ttctgcctta cggttgcatc tcaactggtg acaaaatagg aatgatcgag     2640

attgtaaagg atgccacaac gatcgctcaa attcagcaaa gcacagtggg taacacgggg     2700

gcattcaaag atgaagtcct gaatcactgg ctcaaggaaa aatgtcctat tgaagaaaag     2760

tttcaggccg cagtggaaag gtttgtttac tcctgtgcag gctactgtgt ggccacattt     2820

gttcttggga tcggtgacag gcacaacgac aacattatga tctcagagac aggaaaccta     2880

tttcatatag acttcggaca cattcttggg aattacaaga gtttcctggg catcaataaa     2940

gagagagtgc ccttcgtcct aaccccagac ttcttgtttg tgatgggatc ttctggaaaa     3000

aagacaagtc cacacttcca gaaattccag gatgtctgtg ttagagctta cctagctctt     3060

cgccatcaca caaacctgtt gatcatcttg ttctccatga tgctgatgac aggaatgccc     3120

cagctgacaa gcaaagagga cattgaatat atccgggatg ccctcaccgt gggaaaaagc     3180

gaggaggacg ctaagaaata tttccttgat cagatcgaag tctgcagaga caaaggatgg     3240

actgtgcagt ttaactggtt cctacatctt gttcttggca tcaaacaagg agaaaagcac     3300

tccgcttga                                                             3309


<210>  20
<211>  1102
<212>  PRT
<213>  Mus musculus

<400>  20

Met Glu Leu Glu Asn Tyr Glu Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Leu Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Gly Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Ile Ser Lys Thr Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Glu Phe Tyr His Arg Leu Gly Pro Asp Gln Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Arg 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu His Tyr Trp Lys Leu Met 
        115                 120                 125             


His Lys Ser Pro Gly Gln Ile His Val Val Gln Arg His Val Pro Ser 
    130                 135                 140                 


Glu Glu Thr Leu Ala Phe Gln Lys Gln Leu Thr Ser Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Ile Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Arg Leu Val Thr Pro Arg Met Ala Glu Val Ala Gly Arg Asp 
            180                 185                 190         


Ala Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Asp Tyr Leu Ser Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Gly Thr Thr Ser Gln Thr Ile Lys Val Ser Ala Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Thr Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asn Ile Ser Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Leu Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg Gln Cys Leu Lys Asn Gly Asp Glu Ile His 
    290                 295                 300                 


Leu Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Ala Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Gly Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Cys Lys Thr Pro Ser Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Thr Pro Gly Ser Glu Ser Lys Gly Lys Ala Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg His Gly Asp Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Ala Glu Glu Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Arg Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Ile Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu Gln Asp Phe Thr Gln Gln Val 
                725                 730                 735     


His Val Ile Glu Met Leu Gln Lys Val Thr Ile Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Ser Leu Gln Asn Ser Asn Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Thr Leu Val Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Val Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Gln Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Cys Pro Ile Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Ser Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Ser Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Val Cys Val Arg  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Ser  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  21
<211>  3309
<212>  DNA
<213>  Mus musculus

<400>  21
atggagctgg agaactatga acaaccggtg gttctaagag aggacaacct ccgccggcgc       60

cggaggatga agccacgcag cgcagcaggc agcctgtctt ccatggagct catccccatt      120

gagttcgtac tgcccaccag ccagcgcatc agcaagactc cagaaacagc gctgctgcat      180

gtggctggcc atggcaatgt ggaacagatg aaagctcagg tgtggctgcg cgcactggag      240

accagtgtgg ctgcggagtt ctaccaccga ttgggcccgg accaattcct cctgctctac      300

cagaagaaag gacaatggta tgagatctat gacaggtacc aagtggtgca gaccctagac      360

tgcctgcatt actggaagtt gatgcacaag agccctggcc agatccacgt ggtacagcga      420

cacgtacctt ctgaggagac cttggctttc cagaagcagc tcacctccct gattggctat      480

gacgtcactg acatcagcaa tgtgcacgat gatgagctag agttcactcg ccgccgtctg      540

gttacgcccc gcatggctga agtggctggc cgggatgcca aactctatgc tatgcaccct      600

tgggtaacgt ccaaacctct cccagactac ctgtcaaaaa agattgccaa caactgcatc      660

ttcatcgtca tccaccgcgg taccaccagc caaaccatca aggtctccgc agatgatact      720

cctggtacca tcctccagag cttcttcacc aagatggcca agaagaagtc cctaatgaat      780

atctcagaaa gtcaaagtga gcaggatttt gtattgcggg tttgtggccg cgatgagtac      840

ctggtgggtg aaacacccct caaaaatttc cagtgggtga ggcagtgcct caagaacgga      900

gatgaaatac acctggtgct cgacacgcct ccagacccag cccttgatga ggtgaggaag      960

gaagaatggc cgctggtgga tgactgcact ggagtcaccg gctaccacga gcagctgacc     1020

atccatggca aggaccacga gagtgtgttc acagtgtctt tgtgggactg cgaccgaaag     1080

ttcagggtca agatcagagg cattgatatc cctgtcctgc ctcggaacac cgacctcact     1140

gtgtttgtgg aagcgaacat ccagcacggg caacaagtcc tctgccaaag gagaaccagc     1200

cctaagccct tcgcagaaga ggtactctgg aatgtgtggc tggagtttgg catcaaaatc     1260

aaagacttgc ccaaaggggc tctattgaac ctacagatct actgctgcaa aaccccatca     1320

ctgtccagca aggcttctgc agagactcca ggctccgagt ccaagggcaa agcccagctt     1380

ctctattacg tgaacttgct gttaatagac caccgtttcc tcctccgcca cggggactat     1440

gtgctccaca tgtggcagat atctggcaag gcagaggagc agggcagctt caatgctgac     1500

aagctcacat ccgcaaccaa tcctgacaag gagaactcaa tgtccatttc catcctgctg     1560

gacaattact gtcaccccat agctttgcct aagcaccggc ccacccctga cccagaggga     1620

gacagggttc gggctgaaat gcccaatcag cttcgaaagc aattggaggc gatcatagcc     1680

acagatccac ttaaccccct cacagcagag gacaaagaat tgctctggca ttttcgatat     1740

gaaagcctga agcatccgaa ggcttaccct aagctattca gctcagtgaa atgggggcag     1800

caagaaattg ttgccaaaac gtaccagctg ttagccagaa gggagatctg ggatcaaagt     1860

gctttggacg ttggcttaac catgcagctc ctggactgca acttttcaga cgagaatgtc     1920

cgggccattg cagttcagaa actggagagc ttagaggacg atgacgtttt acattacctt     1980

ctccagctgg tacaggctgt gaaatttgaa ccgtaccacg acagtgcgct ggccagattc     2040

ctgctgaagc gtggcttgag gaacaaaaga atcggtcact tcttgttctg gttcctgcga     2100

agtgagatcg cacagtccag acactatcag cagaggttcg ctgtgatcct ggaggcgtac     2160

ctgcgaggct gtggcacagc catgttgcag gacttcacac agcaggtcca tgtgattgag     2220

atgttacaga aagtcaccat tgatattaaa tcgctctcgg cagagaagta tgacgtcagt     2280

tcccaagtta tttcacagct taagcaaaag cttgaaagcc ttcagaactc caatctcccc     2340

gagagcttta gagttcccta tgatcctgga ctaaaagccg gtaccctggt gatcgagaaa     2400

tgcaaagtga tggcctccaa gaagaagccc ctgtggcttg agtttaagtg tgctgatccc     2460

acagtcctat ccaacgaaac cattggaatc atctttaaac atggtgatga tctgcgccaa     2520

gacatgttga tcttgcagat tctacgcatc atggagtcca tttgggagac tgaatctctg     2580

gacctgtgcc ttctgcctta cggttgcatc tcaactggtg acaaaatagg aatgatcgag     2640

attgtaaagg atgccacaac gatcgctcaa attcagcaaa gcacagtggg taacacgggg     2700

gcattcaaag atgaagtcct gaatcactgg ctcaaggaaa aatgtcctat tgaagaaaag     2760

tttcaggccg cagtggaaag gtttgtttac tcctgtgcag gctactgtgt ggccacattt     2820

gttcttggga tcggtgacag gcacaacgac aacattatga tctcagagac aggaaaccta     2880

tttcatatag acttcggaca cattcttggg aattacaaga gtttcctggg catcaataaa     2940

gagagagtgc ccttcgtcct aaccccagac ttcttgtttg tgatgggatc ttctggaaaa     3000

aagacaagtc cacacttcca gaaattccag gatgtctgtg ttagagctta cctagctctt     3060

cgccatcaca caaacctgtt gatcatcttg ttctccatga tgctgatgac aggaatgccc     3120

cagctgacaa gcaaagagga cattgaatat atccgggatg ccctcaccgt gggaaaaagc     3180

gaggaggacg ctaagaaata tttccttgat cagatcgaag tctgcagaga caaaggatgg     3240

actgtgcagt ttaactggtt cctacatctt gttcttggca tcaaacaagg agaaaagcac     3300

tccgcttga                                                             3309


<210>  22
<211>  1102
<212>  PRT
<213>  Mus musculus

<400>  22

Met Glu Leu Glu Asn Tyr Glu Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Leu Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Gly Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Ile Ser Lys Thr Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Glu Phe Tyr His Arg Leu Gly Pro Asp Gln Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Arg 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu His Tyr Trp Lys Leu Met 
        115                 120                 125             


His Lys Ser Pro Gly Gln Ile His Val Val Gln Arg His Val Pro Ser 
    130                 135                 140                 


Glu Glu Thr Leu Ala Phe Gln Lys Gln Leu Thr Ser Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Ile Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Arg Leu Val Thr Pro Arg Met Ala Glu Val Ala Gly Arg Asp 
            180                 185                 190         


Ala Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Asp Tyr Leu Ser Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Gly Thr Thr Ser Gln Thr Ile Lys Val Ser Ala Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Thr Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asn Ile Ser Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Leu Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg Gln Cys Leu Lys Asn Gly Asp Glu Ile His 
    290                 295                 300                 


Leu Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Ala Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Gly Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Cys Lys Thr Pro Ser Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Thr Pro Gly Ser Glu Ser Lys Gly Lys Ala Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg His Gly Asp Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Ala Glu Glu Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Arg Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Ile Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu Gln Asp Phe Thr Gln Gln Val 
                725                 730                 735     


His Val Ile Glu Met Leu Gln Lys Val Thr Ile Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Ser Leu Gln Asn Ser Asn Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Thr Leu Val Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Val Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Gln Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Cys Pro Ile Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Ser Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Ser Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Val Cys Val Arg  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Ser  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  23
<211>  3309
<212>  DNA
<213>  Mus musculus

<400>  23
atggagctgg agaactatga acaaccggtg gttctaagag aggacaacct ccgccggcgc       60

cggaggatga agccacgcag cgcagcaggc agcctgtctt ccatggagct catccccatt      120

gagttcgtac tgcccaccag ccagcgcatc agcaagactc cagaaacagc gctgctgcat      180

gtggctggcc atggcaatgt ggaacagatg aaagctcagg tgtggctgcg cgcactggag      240

accagtgtgg ctgcggagtt ctaccaccga ttgggcccgg accaattcct cctgctctac      300

cagaagaaag gacaatggta tgagatctat gacaggtacc aagtggtgca gaccctagac      360

tgcctgcatt actggaagtt gatgcacaag agccctggcc agatccacgt ggtacagcga      420

cacgtacctt ctgaggagac cttggctttc cagaagcagc tcacctccct gattggctat      480

gacgtcactg acatcagcaa tgtgcacgat gatgagctag agttcactcg ccgccgtctg      540

gttacgcccc gcatggctga agtggctggc cgggatgcca aactctatgc tatgcaccct      600

tgggtaacgt ccaaacctct cccagactac ctgtcaaaaa agattgccaa caactgcatc      660

ttcatcgtca tccaccgcgg taccaccagc caaaccatca aggtctccgc agatgatact      720

cctggtacca tcctccagag cttcttcacc aagatggcca agaagaagtc cctaatgaat      780

atctcagaaa gtcaaagtga gcaggatttt gtattgcggg tttgtggccg cgatgagtac      840

ctggtgggtg aaacacccct caaaaatttc cagtgggtga ggcagtgcct caagaacgga      900

gatgaaatac acctggtgct cgacacgcct ccagacccag cccttgatga ggtgaggaag      960

gaagaatggc cgctggtgga tgactgcact ggagtcaccg gctaccacga gcagctgacc     1020

atccatggca aggaccacga gagtgtgttc acagtgtctt tgtgggactg cgaccgaaag     1080

ttcagggtca agatcagagg cattgatatc cctgtcctgc ctcggaacac cgacctcact     1140

gtgtttgtgg aagcgaacat ccagcacggg caacaagtcc tctgccaaag gagaaccagc     1200

cctaagccct tcgcagaaga ggtactctgg aatgtgtggc tggagtttgg catcaaaatc     1260

aaagacttgc ccaaaggggc tctattgaac ctacagatct actgctgcaa aaccccatca     1320

ctgtccagca aggcttctgc agagactcca ggctccgagt ccaagggcaa agcccagctt     1380

ctctattacg tgaacttgct gttaatagac caccgtttcc tcctccgcca cggggactat     1440

gtgctccaca tgtggcagat atctggcaag gcagaggagc agggcagctt caatgctgac     1500

aagctcacat ccgcaaccaa tcctgacaag gagaactcaa tgtccatttc catcctgctg     1560

gacaattact gtcaccccat agctttgcct aagcaccggc ccacccctga cccagaggga     1620

gacagggttc gggctgaaat gcccaatcag cttcgaaagc aattggaggc gatcatagcc     1680

acagatccac ttaaccccct cacagcagag gacaaagaat tgctctggca ttttcgatat     1740

gaaagcctga agcatccgaa ggcttaccct aagctattca gctcagtgaa atgggggcag     1800

caagaaattg ttgccaaaac gtaccagctg ttagccagaa gggagatctg ggatcaaagt     1860

gctttggacg ttggcttaac catgcagctc ctggactgca acttttcaga cgagaatgtc     1920

cgggccattg cagttcagaa actggagagc ttagaggacg atgacgtttt acattacctt     1980

ctccagctgg tacaggctgt gaaatttgaa ccgtaccacg acagtgcgct ggccagattc     2040

ctgctgaagc gtggcttgag gaacaaaaga atcggtcact tcttgttctg gttcctgcga     2100

agtgagatcg cacagtccag acactatcag cagaggttcg ctgtgatcct ggaggcgtac     2160

ctgcgaggct gtggcacagc catgttgcag gacttcacac agcaggtcca tgtgattgag     2220

atgttacaga aagtcaccat tgatattaaa tcgctctcgg cagagaagta tgacgtcagt     2280

tcccaagtta tttcacagct taagcaaaag cttgaaagcc ttcagaactc caatctcccc     2340

gagagcttta gagttcccta tgatcctgga ctaaaagccg gtaccctggt gatcgagaaa     2400

tgcaaagtga tggcctccaa gaagaagccc ctgtggcttg agtttaagtg tgctgatccc     2460

acagtcctat ccaacgaaac cattggaatc atctttaaac atggtgatga tctgcgccaa     2520

gacatgttga tcttgcagat tctacgcatc atggagtcca tttgggagac tgaatctctg     2580

gacctgtgcc ttctgcctta cggttgcatc tcaactggtg acaaaatagg aatgatcgag     2640

attgtaaagg atgccacaac gatcgctcaa attcagcaaa gcacagtggg taacacgggg     2700

gcattcaaag atgaagtcct gaatcactgg ctcaaggaaa aatgtcctat tgaagaaaag     2760

tttcaggccg cagtggaaag gtttgtttac tcctgtgcag gctactgtgt ggccacattt     2820

gttcttggga tcggtgacag gcacaacgac aacattatga tctcagagac aggaaaccta     2880

tttcatatag acttcggaca cattcttggg aattacaaga gtttcctggg catcaataaa     2940

gagagagtgc ccttcgtcct aaccccagac ttcttgtttg tgatgggatc ttctggaaaa     3000

aagacaagtc cacacttcca gaaattccag gatgtctgtg ttagagctta cctagctctt     3060

cgccatcaca caaacctgtt gatcatcttg ttctccatga tgctgatgac aggaatgccc     3120

cagctgacaa gcaaagagga cattgaatat atccgggatg ccctcaccgt gggaaaaagc     3180

gaggaggacg ctaagaaata tttccttgat cagatcgaag tctgcagaga caaaggatgg     3240

actgtgcagt ttaactggtt cctacatctt gttcttggca tcaaacaagg agaaaagcac     3300

tccgcttga                                                             3309


<210>  24
<211>  1102
<212>  PRT
<213>  Mus musculus

<400>  24

Met Glu Leu Glu Asn Tyr Glu Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Leu Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Gly Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Ile Ser Lys Thr Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Glu Phe Tyr His Arg Leu Gly Pro Asp Gln Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Arg 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu His Tyr Trp Lys Leu Met 
        115                 120                 125             


His Lys Ser Pro Gly Gln Ile His Val Val Gln Arg His Val Pro Ser 
    130                 135                 140                 


Glu Glu Thr Leu Ala Phe Gln Lys Gln Leu Thr Ser Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Ile Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Arg Leu Val Thr Pro Arg Met Ala Glu Val Ala Gly Arg Asp 
            180                 185                 190         


Ala Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Asp Tyr Leu Ser Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Gly Thr Thr Ser Gln Thr Ile Lys Val Ser Ala Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Thr Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asn Ile Ser Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Leu Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg Gln Cys Leu Lys Asn Gly Asp Glu Ile His 
    290                 295                 300                 


Leu Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Ala Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Gly Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Cys Lys Thr Pro Ser Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Thr Pro Gly Ser Glu Ser Lys Gly Lys Ala Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg His Gly Asp Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Ala Glu Glu Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Arg Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Ile Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu Gln Asp Phe Thr Gln Gln Val 
                725                 730                 735     


His Val Ile Glu Met Leu Gln Lys Val Thr Ile Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Ser Leu Gln Asn Ser Asn Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Thr Leu Val Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Val Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Gln Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Cys Pro Ile Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Ser Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Ser Ser Gly Lys  Lys Thr Ser Pro His  Phe Gln Lys 
        995                 1000                 1005             


Phe Gln  Asp Val Cys Val Arg  Ala Tyr Leu Ala Leu  Arg His His 
    1010                 1015                 1020             


Thr Asn  Leu Leu Ile Ile Leu  Phe Ser Met Met Leu  Met Thr Gly 
    1025                 1030                 1035             


Met Pro  Gln Leu Thr Ser Lys  Glu Asp Ile Glu Tyr  Ile Arg Asp 
    1040                 1045                 1050             


Ala Leu  Thr Val Gly Lys Ser  Glu Glu Asp Ala Lys  Lys Tyr Phe 
    1055                 1060                 1065             


Leu Asp  Gln Ile Glu Val Cys  Arg Asp Lys Gly Trp  Thr Val Gln 
    1070                 1075                 1080             


Phe Asn  Trp Phe Leu His Leu  Val Leu Gly Ile Lys  Gln Gly Glu 
    1085                 1090                 1095             


Lys His  Ser Ala 
    1100         


<210>  25
<211>  3135
<212>  DNA
<213>  Homo sapiens

<400>  25
atgccccctg gggtggactg ccccatggaa ttctggacca aggaggagaa tcagagcgtt       60

gtggttgact tcctgctgcc cacaggggtc tacctgaact tccctgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca gctgctgtgg caccgcgccc agtatgagcc gctcttccac      180

atgctcagtg gccccgaggc ctatgtgttc acctgcatca accagacagc ggagcagcaa      240

gagctggagg acgagcaacg gcgtctgtgt gacgtgcagc ccttcctgcc cgtcctgcgc      300

ctggtggccc gtgagggcga ccgcgtgaag aagctcatca actcacagat cagcctcctc      360

atcggcaaag gcctccacga gtttgactcc ttgtgcgacc cagaagtgaa cgactttcgc      420

gccaagatgt gccaattctg cgaggaggcg gccgcccgcc ggcagcagct gggctgggag      480

gcctggctgc agtacagttt ccccctgcag ctggagccct cggctcaaac ctgggggcct      540

ggtaccctgc ggctcccgaa ccgggccctt ctggtcaacg ttaagtttga gggcagcgag      600

gagagcttca ccttccaggt gtccaccaag gacgtgccgc tggcgctgat ggcctgtgcc      660

ctgcggaaga aggccacagt gttccggcag ccgctggtgg agcagccgga agactacacg      720

ctgcaggtga acggcaggca tgagtacctg tatggcagct acccgctctg ccagttccag      780

tacatctgca gctgcctgca cagtgggttg acccctcacc tgaccatggt ccattcctcc      840

tccatcctcg ccatgcggga tgagcagagc aaccctgccc cccaggtcca gaaaccgcgt      900

gccaaaccac ctcccattcc tgcgaagaag ccttcctctg tgtccctgtg gtccctggag      960

cagccgttcc gcatcgagct catccagggc agcaaagtga acgccgacga gcggatgaag     1020

ctggtggtgc aggccgggct tttccacggc aacgagatgc tgtgcaagac ggtgtccagc     1080

tcggaggtga gcgtgtgctc ggagcccgtg tggaagcagc ggctggagtt cgacatcaac     1140

atctgcgacc tgccccgcat ggcccgtctc tgctttgcgc tgtacgccgt gatcgagaaa     1200

gccaagaagg ctcgctccac caagaagaag tccaagaagg cggactgccc cattgcctgg     1260

gccaacctca tgctgtttga ctacaaggac cagcttaaga ccggggaacg ctgcctctac     1320

atgtggccct ccgtcccaga tgagaagggc gagctgctga accccacggg cactgtgcgc     1380

agtaacccca acacggatag cgccgctgcc ctgctcatct gcctgcccga ggtggccccg     1440

caccccgtgt actaccccgc cctggagaag atcttggagc tggggcgaca cagcgagtgt     1500

gtgcatgtca ccgaggagga gcagctgcag ctgcgggaaa tcctggagcg gcgggggtct     1560

ggggagctgt atgagcacga gaaggacctg gtgtggaagc tgcggcatga agtccaggag     1620

cacttcccgg aggcgctagc ccggctgctg ctggtcacca agtggaacaa gcatgaggat     1680

gtggcccaga tgctctacct gctgtgctcc tggccggagc tgcccgtcct gagcgccctg     1740

gagctgctag acttcagctt ccccgattgc cacgtaggct ccttcgccat caagtcgctg     1800

cggaaactga cggacgatga gctgttccag tacctgctgc agctggtgca ggtgctcaag     1860

tacgagtcct acctggactg cgagctgacc aaattcctgc tggaccgggc cctggccaac     1920

cgcaagatcg gccacttcct tttctggcac ctccgctccg agatgcacgt gccgtcggtg     1980

gccctgcgct tcggcctcat cctggaggcc tactgcaggg gcagcaccca ccacatgaag     2040

gtgctgatga agcaggggga agcactgagc aaactgaagg ccctgaatga cttcgtcaag     2100

ctgagctctc agaagacccc caagccccag accaaggagc tgatgcactt gtgcatgcgg     2160

caggaggcct acctagaggc cctctcccac ctgcagtccc cactcgaccc cagcaccctg     2220

ctggctgaag tctgcgtgga gcagtgcacc ttcatggact ccaagatgaa gcccctgtgg     2280

atcatgtaca gcaacgagga ggcaggcagc ggcggcagcg tgggcatcat ctttaagaac     2340

ggggatgacc tccggcagga catgctgacc ctgcagatga tccagctcat ggacgtcctg     2400

tggaagcagg aggggctgga cctgaggatg accccctatg gctgcctccc caccggggac     2460

cgcacaggcc tcattgaggt ggtactccgt tcagacacca tcgccaacat ccaactcaac     2520

aagagcaaca tggcagccac agccgccttc aacaaggatg ccctgctcaa ctggctgaag     2580

tccaagaacc cgggggaggc cctggatcga gccattgagg agttcaccct ctcctgtgct     2640

ggctattgtg tggccacata tgtgctgggc attggcgatc ggcacagcga caacatcatg     2700

atccgagaga gtgggcagct gttccacatt gattttggcc actttctggg gaatttcaag     2760

accaagtttg gaatcaaccg cgagcgtgtc ccattcatcc tcacctacga ctttgtccat     2820

gtgattcagc aggggaagac taataatagt gagaaatttg aacggttccg gggctactgt     2880

gaaagggcct acaccatcct gcggcgccac gggcttctct tcctccacct ctttgccctg     2940

atgcgggcgg caggcctgcc tgagctcagc tgctccaaag acatccagta tctcaaggac     3000

tccctggcac tggggaaaac agaggaggag gcactgaagc acttccgagt gaagtttaac     3060

gaagccctcc gtgagagctg gaaaaccaaa gtgaactggc tggcccacaa cgtgtccaaa     3120

gacaacaggc agtag                                                      3135


<210>  26
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Asn Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Leu 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Gly 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Ile Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Val Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Cys Asp Pro Glu Val Asn Asp Phe Arg Ala Lys Met Cys 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala Arg Arg Gln Gln Leu Gly Trp Glu 
145                 150                 155                 160 


Ala Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Gln 
                165                 170                 175     


Thr Trp Gly Pro Gly Thr Leu Arg Leu Pro Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Val Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Asp Tyr Thr 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Ser Tyr Pro Leu 
                245                 250                 255     


Cys Gln Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Arg Ile Glu Leu Ile Gln Gly Ser Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Ser Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Ile Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Thr Gly Thr Val Arg Ser Asn Pro Asn 
    450                 455                 460                 


Thr Asp Ser Ala Ala Ala Leu Leu Ile Cys Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Tyr Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Ser Glu Cys Val His Val Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Leu Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val 
                565                 570                 575     


Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys His Val 
            580                 585                 590         


Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu 
        595                 600                 605             


Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr 
    610                 615                 620                 


Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Asp Arg Ala Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His 
                645                 650                 655     


Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Leu Glu Ala Tyr Cys 
            660                 665                 670         


Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala 
        675                 680                 685             


Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Leu Ser Ser Gln 
    690                 695                 700                 


Lys Thr Pro Lys Pro Gln Thr Lys Glu Leu Met His Leu Cys Met Arg 
705                 710                 715                 720 


Gln Glu Ala Tyr Leu Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp 
                725                 730                 735     


Pro Ser Thr Leu Leu Ala Glu Val Cys Val Glu Gln Cys Thr Phe Met 
            740                 745                 750         


Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Asn Glu Glu Ala 
        755                 760                 765             


Gly Ser Gly Gly Ser Val Gly Ile Ile Phe Lys Asn Gly Asp Asp Leu 
    770                 775                 780                 


Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val Leu 
785                 790                 795                 800 


Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys Leu 
                805                 810                 815     


Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu Arg Ser Asp 
            820                 825                 830         


Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr Ala 
        835                 840                 845             


Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn Pro 
    850                 855                 860                 


Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala 
865                 870                 875                 880 


Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His Ser 
                885                 890                 895     


Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp Phe 
            900                 905                 910         


Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg Glu 
        915                 920                 925             


Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln Gln 
    930                 935                 940                 


Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr Cys 
945                 950                 955                 960 


Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu His 
                965                 970                 975     


Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys Ser 
            980                 985                 990         


Lys Asp Ile Gln Tyr Leu Lys Asp  Ser Leu Ala Leu Gly  Lys Thr Glu 
        995                 1000                 1005             


Glu Glu  Ala Leu Lys His Phe  Arg Val Lys Phe Asn  Glu Ala Leu 
    1010                 1015                 1020             


Arg Glu  Ser Trp Lys Thr Lys  Val Asn Trp Leu Ala  His Asn Val 
    1025                 1030                 1035             


Ser Lys  Asp Asn Arg Gln 
    1040                 


<210>  27
<211>  3132
<212>  DNA
<213>  Mus musculus

<400>  27
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gctgcagctg cgggagatcc tggaacggcg gggatccggg     1560

gaactgtacg aacatgagaa ggacctggtg tggaagatgc gccacgaagt ccaggagcat     1620

ttcccagagg cgctggcccg cctgctgctg gtcaccaagt ggaataaaca cgaggatgtg     1680

gcccagatgc tctatttgct gtgctcctgg cccgagctgc ctgtgctgag cgccctggaa     1740

cttctggact ttagctttcc cgactgctac gtgggctcct tcgccatcaa gtcccttcgg     1800

aagctgacgg acgatgagct cttccagtac cttctgcagc tggtgcaagt gctcaaatat     1860

gagtcctacc tggactgcga gctgaccaaa ttcttgctgg gccgagccct ggctaaccgc     1920

aagatcggac acttcctgtt ctggcacctc cgctctgaga tgcacgtacc atcagtggct     1980

ctgcggtttg gtctcatcat ggaagcctac tgcagaggca gcacccacca catgaaggtg     2040

ctgatgaagc agggggaagc actgagcaag cttaaggcac tgaatgactt tgtgaaggtg     2100

agttcccaga agaccaccaa gccccaaacc aaggagatga tgcatatgtg catgcgccag     2160

gagacctaca tggaggccct gtcccacctg cagtctccac tcgaccccag caccctgctg     2220

gaggaagtct gtgtggagca gtgcaccttc atggactcca aaatgaagcc cctgtggatc     2280

atgtacagca gcgaggaggc gggcagtgct ggcaacgtgg gcatcatctt taagaacggg     2340

gatgacctcc gccaggacat gctgactctg cagatgatcc agctcatgga cgtcctgtgg     2400

aagcaggagg gcctggacct gaggatgacg ccctacggct gcctccccac cggggaccgc     2460

acaggtctca tcgaggtggt cctccactcg gacaccatcg ccaacatcca gctgaacaaa     2520

agcaacatgg cggccacagc tgccttcaac aaggacgccc tgctcaactg gctcaagtcc     2580

aagaaccctg gggaggccct ggatcgggcc attgaggaat tcaccctctc ctgtgctggc     2640

tactgtgtgg ccacatatgt tctgggcatc ggtgaccggc acagcgacaa catcatgatc     2700

agagagagtg ggcagctctt ccacattgat tttggccact ttctggggaa cttcaagacc     2760

aagtttggaa tcaaccgaga gcgcgtcccc ttcattctca cctacgactt tgtccacgtg     2820

atccagcagg ggaagactaa caacagtgag aagtttgaaa ggttccgcgg ctactgtgaa     2880

cgagcctata ccatcctgcg gcgccacggg ctgcttttcc tccatctctt cgccctgatg     2940

cgggccgcag gtctgcctga gcttagctgc tccaaagata tccagtatct caaggactct     3000

ctggcactgg ggaagacgga ggaagaggcg ctaaagcact tccgggtgaa gttcaacgaa     3060

gctctccgag aaagctggaa aaccaaagtc aactggctgg cgcacaatgt gtccaaggat     3120

aaccgacagt ag                                                         3132


<210>  28
<211>  1043
<212>  PRT
<213>  Mus musculus

<400>  28

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Leu Gln Leu Arg Glu 
            500                 505                 510         


Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys Asp 
        515                 520                 525             


Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu Ala 
    530                 535                 540                 


Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp Val 
545                 550                 555                 560 


Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val Leu 
                565                 570                 575     


Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys Tyr Val Gly 
            580                 585                 590         


Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu Phe 
        595                 600                 605             


Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr Leu 
    610                 615                 620                 


Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala Leu Ala Asn Arg 
625                 630                 635                 640 


Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His Val 
                645                 650                 655     


Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu Ala Tyr Cys Arg 
            660                 665                 670         


Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala Leu 
        675                 680                 685             


Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val Ser Ser Gln Lys 
    690                 695                 700                 


Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met Cys Met Arg Gln 
705                 710                 715                 720 


Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp Pro 
                725                 730                 735     


Ser Thr Leu Leu Glu Glu Val Cys Val Glu Gln Cys Thr Phe Met Asp 
            740                 745                 750         


Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser Glu Glu Ala Gly 
        755                 760                 765             


Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly Asp Asp Leu Arg 
    770                 775                 780                 


Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val Leu Trp 
785                 790                 795                 800 


Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys Leu Pro 
                805                 810                 815     


Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu His Ser Asp Thr 
            820                 825                 830         


Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr Ala Ala 
        835                 840                 845             


Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn Pro Gly 
    850                 855                 860                 


Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala Gly 
865                 870                 875                 880 


Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His Ser Asp 
                885                 890                 895     


Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp Phe Gly 
            900                 905                 910         


His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg Glu Arg 
        915                 920                 925             


Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln Gln Gly 
    930                 935                 940                 


Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr Cys Glu 
945                 950                 955                 960 


Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu His Leu 
                965                 970                 975     


Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys Ser Lys 
            980                 985                 990         


Asp Ile Gln Tyr Leu Lys Asp Ser  Leu Ala Leu Gly Lys  Thr Glu Glu 
        995                 1000                 1005             


Glu Ala  Leu Lys His Phe Arg  Val Lys Phe Asn Glu  Ala Leu Arg 
    1010                 1015                 1020             


Glu Ser  Trp Lys Thr Lys Val  Asn Trp Leu Ala His  Asn Val Ser 
    1025                 1030                 1035             


Lys Asp  Asn Arg Gln 
    1040             


<210>  29
<211>  3144
<212>  DNA
<213>  Mus musculus

<400>  29
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gcagctgcag ctgcgggaga tcctggaacg gcggggatcc     1560

ggggaactgt acgaacatga gaaggacctg gtgtggaaga tgcgccacga agtccaggag     1620

catttcccag aggcgctggc ccgcctgctg ctggtcacca agtggaataa acacgaggat     1680

gtggcccagc tgtcccagat gctctatttg ctgtgctcct ggcccgagct gcctgtgctg     1740

agcgccctgg aacttctgga ctttagcttt cccgactgct acgtgggctc cttcgccatc     1800

aagtcccttc ggaagctgac ggacgatgag ctcttccagt accttctgca gctggtgcaa     1860

gtgctcaaat atgagtccta cctggactgc gagctgacca aattcttgct gggccgagcc     1920

ctggctaacc gcaagatcgg acacttcctg ttctggcacc tccgctctga gatgcacgta     1980

ccatcagtgg ctctgcggtt tggtctcatc atggaagcct actgcagagg cagcacccac     2040

cacatgaagg tgctgatgaa gcagggggaa gcactgagca agcttaaggc actgaatgac     2100

tttgtgaagg tgagttccca gaagaccacc aagccccaaa ccaaggagat gatgcatatg     2160

tgcatgcgcc aggagaccta catggaggcc ctgtcccacc tgcagtctcc actcgacccc     2220

agcaccctgc tggaggaagt ctgtgtggag cagtgcacct tcatggactc caaaatgaag     2280

cccctgtgga tcatgtacag cagcgaggag gcgggcagtg ctggcaacgt gggcatcatc     2340

tttaagaacg gggatgacct ccgccaggac atgctgactc tgcagatgat ccagctcatg     2400

gacgtcctgt ggaagcagga gggcctggac ctgaggatga cgccctacgg ctgcctcccc     2460

accggggacc gcacaggtct catcgaggtg gtcctccact cggacaccat cgccaacatc     2520

cagctgaaca aaagcaacat ggcggccaca gctgccttca acaaggacgc cctgctcaac     2580

tggctcaagt ccaagaaccc tggggaggcc ctggatcggg ccattgagga attcaccctc     2640

tcctgtgctg gctactgtgt ggccacatat gttctgggca tcggtgaccg gcacagcgac     2700

aacatcatga tcagagagag tgggcagctc ttccacattg attttggcca ctttctgggg     2760

aacttcaaga ccaagtttgg aatcaaccga gagcgcgtcc ccttcattct cacctacgac     2820

tttgtccacg tgatccagca ggggaagact aacaacagtg agaagtttga aaggttccgc     2880

ggctactgtg aacgagccta taccatcctg cggcgccacg ggctgctttt cctccatctc     2940

ttcgccctga tgcgggccgc aggtctgcct gagcttagct gctccaaaga tatccagtat     3000

ctcaaggact ctctggcact ggggaagacg gaggaagagg cgctaaagca cttccgggtg     3060

aagttcaacg aagctctccg agaaagctgg aaaaccaaag tcaactggct ggcgcacaat     3120

gtgtccaagg ataaccgaca gtag                                            3144


<210>  30
<211>  1047
<212>  PRT
<213>  Mus musculus

<400>  30

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Leu Ser Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu 
                565                 570                 575     


Leu Pro Val Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp 
            580                 585                 590         


Cys Tyr Val Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp 
        595                 600                 605             


Asp Glu Leu Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr 
    610                 615                 620                 


Glu Ser Tyr Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala 
625                 630                 635                 640 


Leu Ala Asn Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser 
                645                 650                 655     


Glu Met His Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu 
            660                 665                 670         


Ala Tyr Cys Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln 
        675                 680                 685             


Gly Glu Ala Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val 
    690                 695                 700                 


Ser Ser Gln Lys Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met 
705                 710                 715                 720 


Cys Met Arg Gln Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser 
                725                 730                 735     


Pro Leu Asp Pro Ser Thr Leu Leu Glu Glu Val Cys Val Glu Gln Cys 
            740                 745                 750         


Thr Phe Met Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser 
        755                 760                 765             


Glu Glu Ala Gly Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly 
    770                 775                 780                 


Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met 
785                 790                 795                 800 


Asp Val Leu Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr 
                805                 810                 815     


Gly Cys Leu Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu 
            820                 825                 830         


His Ser Asp Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala 
        835                 840                 845             


Ala Thr Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser 
    850                 855                 860                 


Lys Asn Pro Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu 
865                 870                 875                 880 


Ser Cys Ala Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp 
                885                 890                 895     


Arg His Ser Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His 
            900                 905                 910         


Ile Asp Phe Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile 
        915                 920                 925             


Asn Arg Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val 
    930                 935                 940                 


Ile Gln Gln Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg 
945                 950                 955                 960 


Gly Tyr Cys Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu 
                965                 970                 975     


Phe Leu His Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu 
            980                 985                 990         


Ser Cys Ser Lys Asp Ile Gln Tyr  Leu Lys Asp Ser Leu  Ala Leu Gly 
        995                 1000                 1005             


Lys Thr  Glu Glu Glu Ala Leu  Lys His Phe Arg Val  Lys Phe Asn 
    1010                 1015                 1020             


Glu Ala  Leu Arg Glu Ser Trp  Lys Thr Lys Val Asn  Trp Leu Ala 
    1025                 1030                 1035             


His Asn  Val Ser Lys Asp Asn  Arg Gln 
    1040                 1045         


<210>  31
<211>  3144
<212>  DNA
<213>  Mus musculus

<400>  31
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gcagctgcag ctgcgggaga tcctggaacg gcggggatcc     1560

ggggaactgt acgaacatga gaaggacctg gtgtggaaga tgcgccacga agtccaggag     1620

catttcccag aggcgctggc ccgcctgctg ctggtcacca agtggaataa acacgaggat     1680

gtggcccagc tgtcccagat gctctatttg ctgtgctcct ggcccgagct gcctgtgctg     1740

agcgccctgg aacttctgga ctttagcttt cccgactgct acgtgggctc cttcgccatc     1800

aagtcccttc ggaagctgac ggacgatgag ctcttccagt accttctgca gctggtgcaa     1860

gtgctcaaat atgagtccta cctggactgc gagctgacca aattcttgct gggccgagcc     1920

ctggctaacc gcaagatcgg acacttcctg ttctggcacc tccgctctga gatgcacgta     1980

ccatcagtgg ctctgcggtt tggtctcatc atggaagcct actgcagagg cagcacccac     2040

cacatgaagg tgctgatgaa gcagggggaa gcactgagca agcttaaggc actgaatgac     2100

tttgtgaagg tgagttccca gaagaccacc aagccccaaa ccaaggagat gatgcatatg     2160

tgcatgcgcc aggagaccta catggaggcc ctgtcccacc tgcagtctcc actcgacccc     2220

agcaccctgc tggaggaagt ctgtgtggag cagtgcacct tcatggactc caaaatgaag     2280

cccctgtgga tcatgtacag cagcgaggag gcgggcagtg ctggcaacgt gggcatcatc     2340

tttaagaacg gggatgacct ccgccaggac atgctgactc tgcagatgat ccagctcatg     2400

gacgtcctgt ggaagcagga gggcctggac ctgaggatga cgccctacgg ctgcctcccc     2460

accggggacc gcacaggtct catcgaggtg gtcctccact cggacaccat cgccaacatc     2520

cagctgaaca aaagcaacat ggcggccaca gctgccttca acaaggacgc cctgctcaac     2580

tggctcaagt ccaagaaccc tggggaggcc ctggatcggg ccattgagga attcaccctc     2640

tcctgtgctg gctactgtgt ggccacatat gttctgggca tcggtgaccg gcacagcgac     2700

aacatcatga tcagagagag tgggcagctc ttccacattg attttggcca ctttctgggg     2760

aacttcaaga ccaagtttgg aatcaaccga gagcgcgtcc ccttcattct cacctacgac     2820

tttgtccacg tgatccagca ggggaagact aacaacagtg agaagtttga aaggttccgc     2880

ggctactgtg aacgagccta taccatcctg cggcgccacg ggctgctttt cctccatctc     2940

ttcgccctga tgcgggccgc aggtctgcct gagcttagct gctccaaaga tatccagtat     3000

ctcaaggact ctctggcact ggggaagacg gaggaagagg cgctaaagca cttccgggtg     3060

aagttcaacg aagctctccg agaaagctgg aaaaccaaag tcaactggct ggcgcacaat     3120

gtgtccaagg ataaccgaca gtag                                            3144


<210>  32
<211>  1047
<212>  PRT
<213>  Mus musculus

<400>  32

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Leu Ser Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu 
                565                 570                 575     


Leu Pro Val Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp 
            580                 585                 590         


Cys Tyr Val Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp 
        595                 600                 605             


Asp Glu Leu Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr 
    610                 615                 620                 


Glu Ser Tyr Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala 
625                 630                 635                 640 


Leu Ala Asn Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser 
                645                 650                 655     


Glu Met His Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu 
            660                 665                 670         


Ala Tyr Cys Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln 
        675                 680                 685             


Gly Glu Ala Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val 
    690                 695                 700                 


Ser Ser Gln Lys Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met 
705                 710                 715                 720 


Cys Met Arg Gln Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser 
                725                 730                 735     


Pro Leu Asp Pro Ser Thr Leu Leu Glu Glu Val Cys Val Glu Gln Cys 
            740                 745                 750         


Thr Phe Met Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser 
        755                 760                 765             


Glu Glu Ala Gly Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly 
    770                 775                 780                 


Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met 
785                 790                 795                 800 


Asp Val Leu Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr 
                805                 810                 815     


Gly Cys Leu Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu 
            820                 825                 830         


His Ser Asp Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala 
        835                 840                 845             


Ala Thr Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser 
    850                 855                 860                 


Lys Asn Pro Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu 
865                 870                 875                 880 


Ser Cys Ala Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp 
                885                 890                 895     


Arg His Ser Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His 
            900                 905                 910         


Ile Asp Phe Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile 
        915                 920                 925             


Asn Arg Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val 
    930                 935                 940                 


Ile Gln Gln Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg 
945                 950                 955                 960 


Gly Tyr Cys Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu 
                965                 970                 975     


Phe Leu His Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu 
            980                 985                 990         


Ser Cys Ser Lys Asp Ile Gln Tyr  Leu Lys Asp Ser Leu  Ala Leu Gly 
        995                 1000                 1005             


Lys Thr  Glu Glu Glu Ala Leu  Lys His Phe Arg Val  Lys Phe Asn 
    1010                 1015                 1020             


Glu Ala  Leu Arg Glu Ser Trp  Lys Thr Lys Val Asn  Trp Leu Ala 
    1025                 1030                 1035             


His Asn  Val Ser Lys Asp Asn  Arg Gln 
    1040                 1045         


<210>  33
<211>  3135
<212>  DNA
<213>  Mus musculus

<400>  33
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gcagctgcag ctgcgggaga tcctggaacg gcggggatcc     1560

ggggaactgt acgaacatga gaaggacctg gtgtggaaga tgcgccacga agtccaggag     1620

catttcccag aggcgctggc ccgcctgctg ctggtcacca agtggaataa acacgaggat     1680

gtggcccaga tgctctattt gctgtgctcc tggcccgagc tgcctgtgct gagcgccctg     1740

gaacttctgg actttagctt tcccgactgc tacgtgggct ccttcgccat caagtccctt     1800

cggaagctga cggacgatga gctcttccag taccttctgc agctggtgca agtgctcaaa     1860

tatgagtcct acctggactg cgagctgacc aaattcttgc tgggccgagc cctggctaac     1920

cgcaagatcg gacacttcct gttctggcac ctccgctctg agatgcacgt accatcagtg     1980

gctctgcggt ttggtctcat catggaagcc tactgcagag gcagcaccca ccacatgaag     2040

gtgctgatga agcaggggga agcactgagc aagcttaagg cactgaatga ctttgtgaag     2100

gtgagttccc agaagaccac caagccccaa accaaggaga tgatgcatat gtgcatgcgc     2160

caggagacct acatggaggc cctgtcccac ctgcagtctc cactcgaccc cagcaccctg     2220

ctggaggaag tctgtgtgga gcagtgcacc ttcatggact ccaaaatgaa gcccctgtgg     2280

atcatgtaca gcagcgagga ggcgggcagt gctggcaacg tgggcatcat ctttaagaac     2340

ggggatgacc tccgccagga catgctgact ctgcagatga tccagctcat ggacgtcctg     2400

tggaagcagg agggcctgga cctgaggatg acgccctacg gctgcctccc caccggggac     2460

cgcacaggtc tcatcgaggt ggtcctccac tcggacacca tcgccaacat ccagctgaac     2520

aaaagcaaca tggcggccac agctgccttc aacaaggacg ccctgctcaa ctggctcaag     2580

tccaagaacc ctggggaggc cctggatcgg gccattgagg aattcaccct ctcctgtgct     2640

ggctactgtg tggccacata tgttctgggc atcggtgacc ggcacagcga caacatcatg     2700

atcagagaga gtgggcagct cttccacatt gattttggcc actttctggg gaacttcaag     2760

accaagtttg gaatcaaccg agagcgcgtc cccttcattc tcacctacga ctttgtccac     2820

gtgatccagc aggggaagac taacaacagt gagaagtttg aaaggttccg cggctactgt     2880

gaacgagcct ataccatcct gcggcgccac gggctgcttt tcctccatct cttcgccctg     2940

atgcgggccg caggtctgcc tgagcttagc tgctccaaag atatccagta tctcaaggac     3000

tctctggcac tggggaagac ggaggaagag gcgctaaagc acttccgggt gaagttcaac     3060

gaagctctcc gagaaagctg gaaaaccaaa gtcaactggc tggcgcacaa tgtgtccaag     3120

gataaccgac agtag                                                      3135


<210>  34
<211>  1044
<212>  PRT
<213>  Mus musculus

<400>  34

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val 
                565                 570                 575     


Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys Tyr Val 
            580                 585                 590         


Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu 
        595                 600                 605             


Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr 
    610                 615                 620                 


Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His 
                645                 650                 655     


Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu Ala Tyr Cys 
            660                 665                 670         


Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala 
        675                 680                 685             


Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val Ser Ser Gln 
    690                 695                 700                 


Lys Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met Cys Met Arg 
705                 710                 715                 720 


Gln Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp 
                725                 730                 735     


Pro Ser Thr Leu Leu Glu Glu Val Cys Val Glu Gln Cys Thr Phe Met 
            740                 745                 750         


Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser Glu Glu Ala 
        755                 760                 765             


Gly Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly Asp Asp Leu 
    770                 775                 780                 


Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val Leu 
785                 790                 795                 800 


Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys Leu 
                805                 810                 815     


Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu His Ser Asp 
            820                 825                 830         


Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr Ala 
        835                 840                 845             


Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn Pro 
    850                 855                 860                 


Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala 
865                 870                 875                 880 


Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His Ser 
                885                 890                 895     


Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp Phe 
            900                 905                 910         


Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg Glu 
        915                 920                 925             


Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln Gln 
    930                 935                 940                 


Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr Cys 
945                 950                 955                 960 


Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu His 
                965                 970                 975     


Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys Ser 
            980                 985                 990         


Lys Asp Ile Gln Tyr Leu Lys Asp  Ser Leu Ala Leu Gly  Lys Thr Glu 
        995                 1000                 1005             


Glu Glu  Ala Leu Lys His Phe  Arg Val Lys Phe Asn  Glu Ala Leu 
    1010                 1015                 1020             


Arg Glu  Ser Trp Lys Thr Lys  Val Asn Trp Leu Ala  His Asn Val 
    1025                 1030                 1035             


Ser Lys  Asp Asn Arg Gln 
    1040                 


<210>  35
<211>  3138
<212>  DNA
<213>  Mus musculus

<400>  35
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gcagctgcag ctgcgggaga tcctggaacg gcggggatcc     1560

ggggaactgt acgaacatga gaaggacctg gtgtggaaga tgcgccacga agtccaggag     1620

catttcccag aggcgctggc ccgcctgctg ctggtcacca agtggaataa acacgaggat     1680

gtggcccaga tgctctattt gctgtgctcc tggcccgagc tgcctgtgct gagcgccctg     1740

gaacttctgg actttagctt tcccgactgc tacgtgggct ccttcgccat caagtccctt     1800

cggaagctga cggacgatga gctcttccag taccttctgc agctggtgca agtgctcaaa     1860

tatgagtcct acctggactg cgagctgacc aaattcttgc tgggccgagc cctggctaac     1920

cgcaagatcg gacacttcct gttctggcac ctccgctctg agatgcacgt accatcagtg     1980

gctctgcggt ttggtctcat catggaagcc tactgcagag gcagcaccca ccacatgaag     2040

gtgctgatga agcaggggga agcactgagc aagcttaagg cactgaatga ctttgtgaag     2100

gtgagttccc agaagaccac caagccccaa accaaggaga tgatgcatat gtgcatgcgc     2160

caggagacct acatggaggc cctgtcccac ctgcagtctc cactcgaccc cagcaccctg     2220

ctggaggaag tctgcagtgt ggagcagtgc accttcatgg actccaaaat gaagcccctg     2280

tggatcatgt acagcagcga ggaggcgggc agtgctggca acgtgggcat catctttaag     2340

aacggggatg acctccgcca ggacatgctg actctgcaga tgatccagct catggacgtc     2400

ctgtggaagc aggagggcct ggacctgagg atgacgccct acggctgcct ccccaccggg     2460

gaccgcacag gtctcatcga ggtggtcctc cactcggaca ccatcgccaa catccagctg     2520

aacaaaagca acatggcggc cacagctgcc ttcaacaagg acgccctgct caactggctc     2580

aagtccaaga accctgggga ggccctggat cgggccattg aggaattcac cctctcctgt     2640

gctggctact gtgtggccac atatgttctg ggcatcggtg accggcacag cgacaacatc     2700

atgatcagag agagtgggca gctcttccac attgattttg gccactttct ggggaacttc     2760

aagaccaagt ttggaatcaa ccgagagcgc gtccccttca ttctcaccta cgactttgtc     2820

cacgtgatcc agcaggggaa gactaacaac agtgagaagt ttgaaaggtt ccgcggctac     2880

tgtgaacgag cctataccat cctgcggcgc cacgggctgc ttttcctcca tctcttcgcc     2940

ctgatgcggg ccgcaggtct gcctgagctt agctgctcca aagatatcca gtatctcaag     3000

gactctctgg cactggggaa gacggaggaa gaggcgctaa agcacttccg ggtgaagttc     3060

aacgaagctc tccgagaaag ctggaaaacc aaagtcaact ggctggcgca caatgtgtcc     3120

aaggataacc gacagtag                                                   3138


<210>  36
<211>  1045
<212>  PRT
<213>  Mus musculus

<400>  36

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val 
                565                 570                 575     


Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys Tyr Val 
            580                 585                 590         


Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu 
        595                 600                 605             


Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr 
    610                 615                 620                 


Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His 
                645                 650                 655     


Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu Ala Tyr Cys 
            660                 665                 670         


Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala 
        675                 680                 685             


Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val Ser Ser Gln 
    690                 695                 700                 


Lys Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met Cys Met Arg 
705                 710                 715                 720 


Gln Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp 
                725                 730                 735     


Pro Ser Thr Leu Leu Glu Glu Val Cys Ser Val Glu Gln Cys Thr Phe 
            740                 745                 750         


Met Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser Glu Glu 
        755                 760                 765             


Ala Gly Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly Asp Asp 
    770                 775                 780                 


Leu Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val 
785                 790                 795                 800 


Leu Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys 
                805                 810                 815     


Leu Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu His Ser 
            820                 825                 830         


Asp Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr 
        835                 840                 845             


Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn 
    850                 855                 860                 


Pro Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys 
865                 870                 875                 880 


Ala Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His 
                885                 890                 895     


Ser Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp 
            900                 905                 910         


Phe Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg 
        915                 920                 925             


Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln 
    930                 935                 940                 


Gln Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr 
945                 950                 955                 960 


Cys Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu 
                965                 970                 975     


His Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys 
            980                 985                 990         


Ser Lys Asp Ile Gln Tyr Leu Lys  Asp Ser Leu Ala Leu  Gly Lys Thr 
        995                 1000                 1005             


Glu Glu  Glu Ala Leu Lys His  Phe Arg Val Lys Phe  Asn Glu Ala 
    1010                 1015                 1020             


Leu Arg  Glu Ser Trp Lys Thr  Lys Val Asn Trp Leu  Ala His Asn 
    1025                 1030                 1035             


Val Ser  Lys Asp Asn Arg Gln  
    1040                 1045 


<210>  37
<211>  3141
<212>  DNA
<213>  Mus musculus

<400>  37
atgccccctg gggtggactg ccccatggag ttctggacca aagaggagag ccagagcgtg       60

gttgttgact tcttgctgcc cacaggggtc tacttgaact tccccgtgtc ccgcaatgcc      120

aacctcagca ccatcaagca ggtgctgtgg caccgtgcac agtatgagcc actcttccac      180

atgctcagtg accccgaggc ctatgtgttc acctgtgtga accagacggc ggagcagcag      240

gagttggagg atgagcagcg gaggctgtgc gacatccagc ccttcctgcc cgtgctgcgc      300

ctcgtggccc gagaggggga ccgcgtgaag aagctcatta actcccagat cagcctcctc      360

attggcaaag gtctccatga gtttgattcc ctgcgggacc cggaagtaaa cgacttccgc      420

actaagatgc gccagttttg tgaagaggct gctgctcacc gccagcagct gggctgggtg      480

gaatggctgc agtacagctt ccccctgcag ctggagccct cagcaagggg ttggcgggcc      540

ggcttattgc gtgtcagcaa ccgagccctg ctggtcaacg tgaagttcga gggcagtgag      600

gagagcttca ccttccaggt atccaccaag gacatgcccc tggcactgat ggcctgtgcc      660

ctccgaaaaa aggccacagt gttccggcag cctctggtgg agcagcctga ggaatatgcc      720

ctgcaggtga acgggaggca cgaatacctc tacggcaact acccgctctg ccactttcag      780

tacatctgca gctgcctaca cagcgggctg acccctcatc tgaccatggt ccactcctcc      840

tccatccttg ctatgcggga tgagcagagc aatcctgccc cccaagtaca gaaaccacgt      900

gccaaacctc ccccgatccc tgccaagaag ccctcctctg tgtccctgtg gtccctggaa      960

cagccattct ccattgagct gatcgagggc cgaaaagtga atgctgacga gcggatgaag     1020

ctggttgttc aggccgggct cttccatggc aatgagatgc tgtgcaagac tgtgtcaagc     1080

tcggaggtga atgtatgctc agagcccgtg tggaagcagc gactggagtt cgatatcagc     1140

gtctgtgacc tcccgcgcat ggctcgactc tgttttgctc tctatgccgt cgtggagaag     1200

gctaagaagg cacgctccac aaagaagaag tctaagaagg cggactgccc catcgcttgg     1260

gccaacctca tgctattcga ctacaaagat cagctcaaga cgggggagcg ctgcctctac     1320

atgtggccct ctgtcccaga tgagaaggga gagctgctga atcctgcggg tacagtgcgc     1380

gggaacccca acacggagag tgccgctgcc ctggtcatct acctgcctga ggtggccccc     1440

caccctgtgt acttccccgc tctggagaag atcctggagc tggggcgtca cggggagcgt     1500

gggcgcatca cggaggagga gctgcagctg cgggagatcc tggaacggcg gggatccggg     1560

gaactgtacg aacatgagaa ggacctggtg tggaagatgc gccacgaagt ccaggagcat     1620

ttcccagagg cgctggcccg cctgctgctg gtcaccaagt ggaataaaca cgaggatgtg     1680

gcccagctgt cccagatgct ctatttgctg tgctcctggc ccgagctgcc tgtgctgagc     1740

gccctggaac ttctggactt tagctttccc gactgctacg tgggctcctt cgccatcaag     1800

tcccttcgga agctgacgga cgatgagctc ttccagtacc ttctgcagct ggtgcaagtg     1860

ctcaaatatg agtcctacct ggactgcgag ctgaccaaat tcttgctggg ccgagccctg     1920

gctaaccgca agatcggaca cttcctgttc tggcacctcc gctctgagat gcacgtacca     1980

tcagtggctc tgcggtttgg tctcatcatg gaagcctact gcagaggcag cacccaccac     2040

atgaaggtgc tgatgaagca gggggaagca ctgagcaagc ttaaggcact gaatgacttt     2100

gtgaaggtga gttcccagaa gaccaccaag ccccaaacca aggagatgat gcatatgtgc     2160

atgcgccagg agacctacat ggaggccctg tcccacctgc agtctccact cgaccccagc     2220

accctgctgg aggaagtctg tgtggagcag tgcaccttca tggactccaa aatgaagccc     2280

ctgtggatca tgtacagcag cgaggaggcg ggcagtgctg gcaacgtggg catcatcttt     2340

aagaacgggg atgacctccg ccaggacatg ctgactctgc agatgatcca gctcatggac     2400

gtcctgtgga agcaggaggg cctggacctg aggatgacgc cctacggctg cctccccacc     2460

ggggaccgca caggtctcat cgaggtggtc ctccactcgg acaccatcgc caacatccag     2520

ctgaacaaaa gcaacatggc ggccacagct gccttcaaca aggacgccct gctcaactgg     2580

ctcaagtcca agaaccctgg ggaggccctg gatcgggcca ttgaggaatt caccctctcc     2640

tgtgctggct actgtgtggc cacatatgtt ctgggcatcg gtgaccggca cagcgacaac     2700

atcatgatca gagagagtgg gcagctcttc cacattgatt ttggccactt tctggggaac     2760

ttcaagacca agtttggaat caaccgagag cgcgtcccct tcattctcac ctacgacttt     2820

gtccacgtga tccagcaggg gaagactaac aacagtgaga agtttgaaag gttccgcggc     2880

tactgtgaac gagcctatac catcctgcgg cgccacgggc tgcttttcct ccatctcttc     2940

gccctgatgc gggccgcagg tctgcctgag cttagctgct ccaaagatat ccagtatctc     3000

aaggactctc tggcactggg gaagacggag gaagaggcgc taaagcactt ccgggtgaag     3060

ttcaacgaag ctctccgaga aagctggaaa accaaagtca actggctggc gcacaatgtg     3120

tccaaggata accgacagta g                                               3141


<210>  38
<211>  1046
<212>  PRT
<213>  Mus musculus

<400>  38

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Ser Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Val 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Asp 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Val Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Ile Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Arg Asp Pro Glu Val Asn Asp Phe Arg Thr Lys Met Arg 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala His Arg Gln Gln Leu Gly Trp Val 
145                 150                 155                 160 


Glu Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Arg 
                165                 170                 175     


Gly Trp Arg Ala Gly Leu Leu Arg Val Ser Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Met Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Glu Tyr Ala 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Asn Tyr Pro Leu 
                245                 250                 255     


Cys His Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Ser Ile Glu Leu Ile Glu Gly Arg Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Asn Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Ser Val Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Val Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Ala Gly Thr Val Arg Gly Asn Pro Asn 
    450                 455                 460                 


Thr Glu Ser Ala Ala Ala Leu Val Ile Tyr Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Phe Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Gly Glu Arg Gly Arg Ile Thr Glu Glu Glu Leu Gln Leu Arg Glu 
            500                 505                 510         


Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys Asp 
        515                 520                 525             


Leu Val Trp Lys Met Arg His Glu Val Gln Glu His Phe Pro Glu Ala 
    530                 535                 540                 


Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp Val 
545                 550                 555                 560 


Ala Gln Leu Ser Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu 
                565                 570                 575     


Pro Val Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys 
            580                 585                 590         


Tyr Val Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp 
        595                 600                 605             


Glu Leu Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu 
    610                 615                 620                 


Ser Tyr Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Gly Arg Ala Leu 
625                 630                 635                 640 


Ala Asn Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu 
                645                 650                 655     


Met His Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Met Glu Ala 
            660                 665                 670         


Tyr Cys Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly 
        675                 680                 685             


Glu Ala Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Val Ser 
    690                 695                 700                 


Ser Gln Lys Thr Thr Lys Pro Gln Thr Lys Glu Met Met His Met Cys 
705                 710                 715                 720 


Met Arg Gln Glu Thr Tyr Met Glu Ala Leu Ser His Leu Gln Ser Pro 
                725                 730                 735     


Leu Asp Pro Ser Thr Leu Leu Glu Glu Val Cys Val Glu Gln Cys Thr 
            740                 745                 750         


Phe Met Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Ser Glu 
        755                 760                 765             


Glu Ala Gly Ser Ala Gly Asn Val Gly Ile Ile Phe Lys Asn Gly Asp 
    770                 775                 780                 


Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp 
785                 790                 795                 800 


Val Leu Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly 
                805                 810                 815     


Cys Leu Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu His 
            820                 825                 830         


Ser Asp Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala 
        835                 840                 845             


Thr Ala Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys 
    850                 855                 860                 


Asn Pro Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser 
865                 870                 875                 880 


Cys Ala Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg 
                885                 890                 895     


His Ser Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile 
            900                 905                 910         


Asp Phe Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn 
        915                 920                 925             


Arg Glu Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile 
    930                 935                 940                 


Gln Gln Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly 
945                 950                 955                 960 


Tyr Cys Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe 
                965                 970                 975     


Leu His Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser 
            980                 985                 990         


Cys Ser Lys Asp Ile Gln Tyr Leu  Lys Asp Ser Leu Ala  Leu Gly Lys 
        995                 1000                 1005             


Thr Glu  Glu Glu Ala Leu Lys  His Phe Arg Val Lys  Phe Asn Glu 
    1010                 1015                 1020             


Ala Leu  Arg Glu Ser Trp Lys  Thr Lys Val Asn Trp  Leu Ala His 
    1025                 1030                 1035             


Asn Val  Ser Lys Asp Asn Arg  Gln 
    1040                 1045     


<210>  39
<211>  921
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (25)..(888)

<400>  39
cactctggtg gggctgctcc aggc atg cag atc cca cag gcg ccc tgg cca          51
                           Met Gln Ile Pro Gln Ala Pro Trp Pro            
                           1               5                              

gtc gtc tgg gcg gtg cta caa ctg ggc tgg cgg cca gga tgg ttc tta         99
Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu           
10                  15                  20                  25            

gac tcc cca gac agg ccc tgg aac ccc ccc acc ttc tcc cca gcc ctg        147
Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu           
                30                  35                  40                

ctc gtg gtg acc gaa ggg gac aac gcc acc ttc acc tgc agc ttc tcc        195
Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser           
            45                  50                  55                    

aac aca tcg gag agc ttc gtg cta aac tgg tac cgc atg agc ccc agc        243
Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser           
        60                  65                  70                        

aac cag acg gac aag ctg gcc gcc ttc ccc gag gac cgc agc cag ccc        291
Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro           
    75                  80                  85                            

ggc cag gac tgc cgc ttc cgt gtc aca caa ctg ccc aac ggg cgt gac        339
Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp           
90                  95                  100                 105           

ttc cac atg agc gtg gtc agg gcc cgg cgc aat gac agc ggc acc tac        387
Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr           
                110                 115                 120               

ctc tgt ggg gcc atc tcc ctg gcc ccc aag gcg cag atc aaa gag agc        435
Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser           
            125                 130                 135                   

ctg cgg gca gag ctc agg gtg aca gag aga agg gca gaa gtg ccc aca        483
Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr           
        140                 145                 150                       

gcc cac ccc agc ccc tca ccc agg tca gcc ggc cag ttc caa acc ctg        531
Ala His Pro Ser Pro Ser Pro Arg Ser Ala Gly Gln Phe Gln Thr Leu           
    155                 160                 165                           

gtg gtt ggt gtc gtg ggc ggc ctg ctg ggc agc ctg gtg ctg cta gtc        579
Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val           
170                 175                 180                 185           

tgg gtc ctg gcc gtc atc tgc tcc cgg gcc gca cga ggg aca ata gga        627
Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly           
                190                 195                 200               

gcc agg cgc acc ggc cag ccc ctg aag gag gac ccc tca gcc gtg cct        675
Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro           
            205                 210                 215                   

gtg ttc tct gtg gac tat ggg gag ctg gat ttc cag tgg cga gag aag        723
Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys           
        220                 225                 230                       

acc ccg gag ccc ccc gtg ccc tgt gtc cct gag cag acg gag tat gcc        771
Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala           
    235                 240                 245                           

acc att gtc ttt cct agc gga atg ggc acc tca tcc ccc gcc cgc agg        819
Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg           
250                 255                 260                 265           

ggc tca gct gac ggc cct cgg agt gcc cag cca ctg agg cct gag gat        867
Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp           
                270                 275                 280               

gga cac tgc tct tgg ccc ctc tgaccggctt ccttggccac cagtgttctg cag       921
Gly His Cys Ser Trp Pro Leu                                               
            285                                                           


<210>  40
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Ser Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  41
<211>  968
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (59)..(793)

<400>  41
gcttcccgag gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaag         58

atg agg ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg        106
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu           
1               5                   10                  15                

aac gca ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat        154
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr           
            20                  25                  30                    

ggt agc aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta        202
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu           
        35                  40                  45                        

gac ctg gct gca cta att gtc tat tgg gaa atg gag gat aag aac att        250
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile           
    50                  55                  60                            

att caa ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc        298
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser           
65                  70                  75                  80            

tac aga cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat        346
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn           
                85                  90                  95                

gct gca ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac        394
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr           
            100                 105                 110                   

cgc tgc atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg        442
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val           
        115                 120                 125                       

aaa gtc aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg        490
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val           
    130                 135                 140                           

gat cca gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac        538
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr           
145                 150                 155                 160           

ccc aag gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt        586
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser           
                165                 170                 175               

ggt aag acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat        634
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn           
            180                 185                 190                   

gtg acc agc aca ctg aga atc aac aca aca act aat gag att ttc tac        682
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr           
        195                 200                 205                       

tgc act ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg        730
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu           
    210                 215                 220                           

gtc atc cca ggt aat att ctg aat gtg tcc att aaa ata tgt cta aca        778
Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr           
225                 230                 235                 240           

ctg tcc cct agc acc tagcatgatg tctgcctatc atagtcattc agtgattgtt        833
Leu Ser Pro Ser Thr                                                       
                245                                                       

gaataaatga atgaatgaat aacactatgt ttacaaaata tatcctaatt cctcacctcc      893

attcatccaa accatattgt tacttaataa acattcagca gatatttatg gaataaaaaa      953

aaaaaaaaaa aaaaa                                                       968


<210>  42
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  43
<211>  1553
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (53)..(922)

<400>  43
cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa ag atg agg       58
                                                          Met Arg         
                                                          1               

ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg aac gca        106
Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala           
        5                   10                  15                        

ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat ggt agc        154
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser           
    20                  25                  30                            

aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta gac ctg        202
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu           
35                  40                  45                  50            

gct gca cta att gtc tat tgg gaa atg gag gat aag aac att att caa        250
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln           
                55                  60                  65                

ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc tac aga        298
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg           
            70                  75                  80                    

cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat gct gca        346
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala           
        85                  90                  95                        

ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac cgc tgc        394
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys           
    100                 105                 110                           

atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg aaa gtc        442
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val           
115                 120                 125                 130           

aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg gat cca        490
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro           
                135                 140                 145               

gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac ccc aag        538
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys           
            150                 155                 160                   

gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt ggt aag        586
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys           
        165                 170                 175                       

acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat gtg acc        634
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr           
    180                 185                 190                           

agc aca ctg aga atc aac aca aca act aat gag att ttc tac tgc act        682
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr           
195                 200                 205                 210           

ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg gtc atc        730
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile           
                215                 220                 225               

cca gaa cta cct ctg gca cat cct cca aat gaa agg act cac ttg gta        778
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val           
            230                 235                 240                   

att ctg gga gcc atc tta tta tgc ctt ggt gta gca ctg aca ttc atc        826
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile           
        245                 250                 255                       

ttc cgt tta aga aaa ggg aga atg atg gat gtg aaa aaa tgt ggc atc        874
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile           
    260                 265                 270                           

caa gat aca aac tca aag aag caa agt gat aca cat ttg gag gag acg        922
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr           
275                 280                 285                 290           

taatccagca ttggaacttc tgatcttcaa gcagggattc tcaacctgtg gtttaggggt      982

tcatcggggc tgagcgtgac aagaggaagg aatgggcccg tgggatgcag gcaatgtggg     1042

acttaaaagg cccaagcact gaaaatggaa cctggcgaaa gcagaggagg agaatgaaga     1102

aagatggagt caaacaggga gcctggaggg agaccttgat actttcaaat gcctgagggg     1162

ctcatcgacg cctgtgacag ggagaaagga tacttctgaa caaggagcct ccaagcaaat     1222

catccattgc tcatcctagg aagacgggtt gagaatccct aatttgaggg tcagttcctg     1282

cagaagtgcc ctttgcctcc actcaatgcc tcaatttgtt ttctgcatga ctgagagtct     1342

cagtgttgga acgggacagt atttatgtat gagtttttcc tatttatttt gagtctgtga     1402

ggtcttcttg tcatgtgagt gtggttgtga atgatttctt ttgaagatat attgtagtag     1462

atgttacaat tttgtcgcca aactaaactt gctgcttaat gatttgctca catctagtaa     1522

aacatggagt atttgtaaaa aaaaaaaaaa a                                    1553


<210>  44
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  45
<211>  819
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(819)

<400>  45
atg atc ttc ctc ctg cta atg ttg agc ctg gaa ttg cag ctt cac cag         48
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln           
1               5                   10                  15                

ata gca gct tta ttc aca gtg aca gtc cct aag gaa ctg tac ata ata         96
Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile           
            20                  25                  30                    

gag cat ggc agc aat gtg acc ctg gaa tgc aac ttt gac act gga agt        144
Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser           
        35                  40                  45                        

cat gtg aac ctt gga gca ata aca gcc agt ttg caa aag gtg gaa aat        192
His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn           
    50                  55                  60                            

gat aca tcc cca cac cgt gaa aga gcc act ttg ctg gag gag cag ctg        240
Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu           
65                  70                  75                  80            

ccc cta ggg aag gcc tcg ttc cac ata cct caa gtc caa gtg agg gac        288
Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp           
                85                  90                  95                

gaa gga cag tac caa tgc ata atc atc tat ggg gtc gcc tgg gac tac        336
Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr           
            100                 105                 110                   

aag tac ctg act ctg aaa gtc aaa gct tcc tac agg aaa ata aac act        384
Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr           
        115                 120                 125                       

cac atc cta aag gtt cca gaa aca gat gag gta gag ctc acc tgc cag        432
His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln           
    130                 135                 140                           

gct aca ggt tat cct ctg gca gaa gta tcc tgg cca aac gtc agc gtt        480
Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val           
145                 150                 155                 160           

cct gcc aac acc agc cac tcc agg acc cct gaa ggc ctc tac cag gtc        528
Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val           
                165                 170                 175               

acc agt gtt ctg cgc cta aag cca ccc cct ggc aga aac ttc agc tgt        576
Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys           
            180                 185                 190                   

gtg ttc tgg aat act cac gtg agg gaa ctt act ttg gcc agc att gac        624
Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp           
        195                 200                 205                       

ctt caa agt cag atg gaa ccc agg acc cat cca act tgg ctg ctt cac        672
Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His           
    210                 215                 220                           

att ttc atc ccc tcc tgc atc att gct ttc att ttc ata gcc aca gtg        720
Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val           
225                 230                 235                 240           

ata gcc cta aga aaa caa ctc tgt caa aag ctg tat tct tca aaa gac        768
Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp           
                245                 250                 255               

aca aca aaa aga cct gtc acc aca aca aag agg gaa gtg aac agt gct        816
Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala           
            260                 265                 270                   

atc                                                                    819
Ile                                                                       
                                                                          


<210>  46
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile
 

<210>  47
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  47
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga      600

ataggcatct acatcggagc agggatctgt gctgggctgg ctctggctct tatcttcggc      660

gctttaattt tcaaatggta ttctcatagc aaagagaaga tacagaattt aagcctcatc      720

tctttggcca acctccctcc ctcaggattg gcaaatgcag tagcagaggg aattcgctca      780

gaagaaaaca tctataccat tgaagagaac gtatatgaag tggaggagcc caatgagtat      840

tattgctatg tcagcagcag gcagcaaccc tcacaacctt tgggttgtcg ctttgcaatg      900

ccatag                                                                 906


<210>  48
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  49
<211>  846
<212>  DNA
<213>  Mus musculus

<400>  49
atgttttcag gtcttaccct caactgtgtc ctgctgctgc tgcaactact acttgcaagg       60

tcattggaaa atgcttatgt gtttgaggtt ggtaagaatg cctatctgcc ctgcagttac      120

actctatcta cacctggggc acttgtgcct atgtgctggg gcaagggatt ctgtccttgg      180

tcacagtgta ccaacgagtt gctcagaact gatgaaagaa atgtgacata tcagaaatcc      240

agcagatacc agctaaaggg cgatctcaac aaaggagacg tgtctctgat cataaagaat      300

gtgactctgg atgaccatgg gacctactgc tgcaggatac agttccctgg tcttatgaat      360

gataaaaaat tagaactgaa attagacatc aaagcagcca aggtcactcc agctcagact      420

gcccatgggg actctactac agcttctcca agaaccctaa ccacggagag aaatggttca      480

gagacacaga cactggtgac cctccataat aacaatggaa caaaaatttc cacatgggct      540

gatgaaatta aggactctgg agaaacgatc agaactgcta tccacattgg agtgggagtc      600

tctgctgggt tgaccctggc acttatcatt ggtgtcttaa tccttaaatg gtattcctgt      660

aagaaaaaga agttatcgag tttgagcctt attacactgg ccaacttgcc tccaggaggg      720

ttggcaaatg caggagcagt caggattcgc tctgaggaaa atatctacac catcgaggag      780

aacgtatatg aagtggagaa ttcaaatgag tactactgct acgtcaacag ccagcagcca      840

tcctga                                                                 846


<210>  50
<211>  281
<212>  PRT
<213>  Mus musculus

<400>  50

Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asn Ala Tyr Val Phe Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Ser Thr Pro Gly Ala Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


<210>  51
<211>  1578
<212>  DNA
<213>  Homo sapiens

<400>  51
atgtgggagg ctcagttcct gggcttgctg tttctgcagc cgctttgggt ggctccagtg       60

aagcctctcc agccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc      120

cagctcccct gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg      180

gtcacttggc agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg      240

gcccccggcc ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg      300

gtgctgagcg tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc      360

cagctggatg agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg      420

cgcgcggacg ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc      480

cgcctccgtc tgcgcctggg ccaggcctcg atgactgcca gccccccagg atctctcaga      540

gcctccgact gggtcatttt gaactgctcc ttcagccgcc ctgaccgccc agcctctgtg      600

cattggttcc ggaaccgggg ccagggccga gtccctgtcc gggagtcccc ccatcaccac      660

ttagcggaaa gcttcctctt cctgccccaa gtcagcccca tggactctgg gccctggggc      720

tgcatcctca cctacagaga tggcttcaac gtctccatca tgtataacct cactgttctg      780

ggtctggagc ccccaactcc cttgacagtg tacgctggag caggttccag ggtggggctg      840

ccctgccgcc tgcctgctgg tgtggggacc cggtctttcc tcactgccaa gtggactcct      900

cctgggggag gccctgacct cctggtgact ggagacaatg gcgactttac ccttcgacta      960

gaggatgtga gccaggccca ggctgggacc tacacctgcc atatccatct gcaggaacag     1020

cagctcaatg ccactgtcac attggcaatc atcacagtga ctcccaaatc ctttgggtca     1080

cctggatccc tggggaagct gctttgtgag gtgactccag tatctggaca agaacgcttt     1140

gtgtggagct ctctggacac cccatcccag aggagtttct caggaccttg gctggaggca     1200

caggaggccc agctcctttc ccagccttgg caatgccagc tgtaccaggg ggagaggctt     1260

cttggagcag cagtgtactt cacagagctg tctagcccag gtgcccaacg ctctgggaga     1320

gccccaggtg ccctcccagc aggccacctc ctgctgtttc tcatccttgg tgtcctttct     1380

ctgctccttt tggtgactgg agcctttggc tttcaccttt ggagaagaca gtggcgacca     1440

agacgatttt ctgccttaga gcaagggatt caccctccgc aggctcagag caagatagag     1500

gagctggagc aagaaccgga gccggagccg gagccggaac cggagcccga gcccgagccc     1560

gagccggagc agctctga                                                   1578


<210>  52
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  53
<211>  1566
<212>  DNA
<213>  Mus musculus

<400>  53
atgagggagg acctgctcct tggctttttg cttctgggac tgctttggga agctccagtt       60

gtgtcttcag ggcctgggaa agagctcccc gtggtgtggg cccaggaggg agctcccgtc      120

catcttccct gcagcctcaa atcccccaac ctggatccta actttctacg aagaggaggg      180

gttatctggc aacatcaacc agacagtggc caacccactc ccatcccggc ccttgacctt      240

caccagggga tgccctcgcc tagacaaccc gcacccggtc gctacacggt gctgagcgtg      300

gctccaggag gcctgcgcag cgggaggcag cccctgcatc cccacgtgca gctggaggag      360

cgcggcctcc agcgcgggga cttctctctg tggttgcgcc cagctctgcg caccgatgcg      420

ggcgagtacc acgccaccgt gcgcctcccg aaccgcgccc tctcctgcag tctccgcctg      480

cgcgtcggcc aggcctcgat gattgctagt ccctcaggag tcctcaagct gtctgattgg      540

gtccttttga actgctcctt cagccgtcct gaccgcccag tctctgtgca ctggttccag      600

ggccagaacc gagtgcctgt ctacaactca ccgcgtcatt ttttagctga aactttcctg      660

ttactgcccc aagtcagccc cctggactct gggacctggg gctgtgtcct cacctacaga      720

gatggcttca atgtctccat cacgtacaac ctcaaggttc tgggtctgga gcccgtagcc      780

cctctgacag tgtacgctgc tgaaggttct agggtggagc tgccctgtca tttgccccca      840

ggagtgggga ccccttcttt gctcattgcc aagtggactc ctcctggagg aggtcctgag      900

ctccccgtgg ctggaaagag tggcaatttt acccttcacc ttgaggctgt gggtctggca      960

caggctggga cctacacctg tagcatccat ctgcagggac agcagctcaa tgccactgtc     1020

acgttggcgg tcatcacagt gactcccaaa tccttcgggt tacctggctc ccgggggaag     1080

ctgttgtgtg aggtaacccc ggcatctgga aaggaaagat ttgtgtggcg tcccctgaac     1140

aatctgtcca ggagttgccc gggccctgtg ctggagattc aggaggccag gctccttgct     1200

gagcgatggc agtgtcagct gtacgagggc cagaggcttc ttggagcgac agtgtacgcc     1260

gcagagtcta gctcaggcgc ccacagtgct aggagaatct caggtgacct taaaggaggc     1320

catctcgttc tcgttctcat ccttggtgcc ctctccctgt tccttttggt ggccggggcc     1380

tttggctttc actggtggag aaaacagttg ctactgagaa gattttctgc cttagaacat     1440

gggattcagc catttccggc tcagaggaag atagaggagc tggagcgaga actggagacg     1500

gagatgggac aggagccgga gcccgagccg gagccacagc tggagccaga gcccaggcag     1560

ctctga                                                                1566


<210>  54
<211>  521
<212>  PRT
<213>  Mus musculus

<400>  54

Met Arg Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Lys Glu Leu Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Val His Leu Pro Cys Ser Leu Lys Ser 
        35                  40                  45              


Pro Asn Leu Asp Pro Asn Phe Leu Arg Arg Gly Gly Val Ile Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Gln Pro Thr Pro Ile Pro Ala Leu Asp Leu 
65                  70                  75                  80  


His Gln Gly Met Pro Ser Pro Arg Gln Pro Ala Pro Gly Arg Tyr Thr 
                85                  90                  95      


Val Leu Ser Val Ala Pro Gly Gly Leu Arg Ser Gly Arg Gln Pro Leu 
            100                 105                 110         


His Pro His Val Gln Leu Glu Glu Arg Gly Leu Gln Arg Gly Asp Phe 
        115                 120                 125             


Ser Leu Trp Leu Arg Pro Ala Leu Arg Thr Asp Ala Gly Glu Tyr His 
    130                 135                 140                 


Ala Thr Val Arg Leu Pro Asn Arg Ala Leu Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Arg Val Gly Gln Ala Ser Met Ile Ala Ser Pro Ser Gly Val Leu Lys 
                165                 170                 175     


Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg 
            180                 185                 190         


Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg Val Pro Val Tyr 
        195                 200                 205             


Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu Leu Leu Pro Gln 
    210                 215                 220                 


Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val Leu Thr Tyr Arg 
225                 230                 235                 240 


Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys Val Leu Gly Leu 
                245                 250                 255     


Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu Gly Ser Arg Val 
            260                 265                 270         


Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr Pro Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu Leu Pro Val Ala 
    290                 295                 300                 


Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala Val Gly Leu Ala 
305                 310                 315                 320 


Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln Gly Gln Gln Leu 
                325                 330                 335     


Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr Pro Lys Ser Phe 
            340                 345                 350         


Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
        355                 360                 365             


Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn Asn Leu Ser Arg 
    370                 375                 380                 


Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg Leu Leu Gly Ala 
                405                 410                 415     


Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His Ser Ala Arg Arg 
            420                 425                 430         


Ile Ser Gly Asp Leu Lys Gly Gly His Leu Val Leu Val Leu Ile Leu 
        435                 440                 445             


Gly Ala Leu Ser Leu Phe Leu Leu Val Ala Gly Ala Phe Gly Phe His 
    450                 455                 460                 


Trp Trp Arg Lys Gln Leu Leu Leu Arg Arg Phe Ser Ala Leu Glu His 
465                 470                 475                 480 


Gly Ile Gln Pro Phe Pro Ala Gln Arg Lys Ile Glu Glu Leu Glu Arg 
                485                 490                 495     


Glu Leu Glu Thr Glu Met Gly Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Gln Leu Glu Pro Glu Pro Arg Gln Leu 
        515                 520