                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Biomarkers Predictive Of Endocrine Resistance In Breast Cancer

<130>  DFS-167.25

<140>  PCT/US2017/041335
<141>  2017-07-10

<150>  62/363,029
<151>  2016-07-15

<160>  329   

<170>  PatentIn version 3.5

<210>  1
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtcagcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcactg ccgagcagga cctgcccttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gagactacac gctgtgcgtg      360

agctgcgacg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacagt ggcggcccag      540

gatgagttct accgcagcgg ctgggccctg aacatgaagg agctgaagct gctgcagacc      600

atcgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgcc      660

gtcaagtgca ttaagaacga cgccactgcc caggccttcc tggctgaagc ctcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc ttgtggacta cctgcggtct      840

aggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaatttc gtgcatcgag acctggctgc ccgcaatgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgacggc tgcccgcccg cagtctatga agtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccctccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccacga gctgcacctg tga                                  1353


<210>  2
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtcagcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcactg ccgagcagga cctgcccttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gagactacac gctgtgcgtg      360

agctgcgacg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacagt ggcggcccag      540

gatgagttct accgcagcgg ctgggccctg aacatgaagg agctgaagct gctgcagacc      600

atcgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgcc      660

gtcaagtgca ttaagaacga cgccactgcc caggccttcc tggctgaagc ctcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc ttgtggacta cctgcggtct      840

aggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaatttc gtgcatcgag acctggctgc ccgcaatgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgacggc tgcccgcccg cagtctatga agtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccctccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccacga gctgcacctg tga                                  1353


<210>  3
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtcagcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcactg ccgagcagga cctgcccttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gagactacac gctgtgcgtg      360

agctgcgacg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacagt ggcggcccag      540

gatgagttct accgcagcgg ctgggccctg aacatgaagg agctgaagct gctgcagacc      600

atcgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgcc      660

gtcaagtgca ttaagaacga cgccactgcc caggccttcc tggctgaagc ctcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc ttgtggacta cctgcggtct      840

aggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaatttc gtgcatcgag acctggctgc ccgcaatgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgacggc tgcccgcccg cagtctatga agtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccctccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccacga gctgcacctg tga                                  1353


<210>  4
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtcagcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcactg ccgagcagga cctgcccttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gagactacac gctgtgcgtg      360

agctgcgacg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacagt ggcggcccag      540

gatgagttct accgcagcgg ctgggccctg aacatgaagg agctgaagct gctgcagacc      600

atcgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgcc      660

gtcaagtgca ttaagaacga cgccactgcc caggccttcc tggctgaagc ctcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc ttgtggacta cctgcggtct      840

aggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaatttc gtgcatcgag acctggctgc ccgcaatgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgacggc tgcccgcccg cagtctatga agtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccctccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccacga gctgcacctg tga                                  1353


<210>  5
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  6
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  7
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  8
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  9
<211>  1353
<212>  DNA
<213>  Mus musculus

<400>  9
atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag      300

acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt      420

gatgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gatggactct gcactcgcct catcaaacca aaggtcatgg agggcaccgt ggcggcccag      540

gatgagttct accgcagtgg ctgggcactg aacatgaagg aactgaagct gctacagaca      600

atagggaagg gggagtttgg agatgtgatg ctgggggatt accggggcaa caaagttgca      660

gtcaagtgca tcaagaatga cgcaactgcc caggccttcc tggctgaagc ctccgtcatg      720

acgcaacttc ggcacagcaa cctcgtccag ctgctgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg tggagactgt ctcctcaaat tctcattaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aagacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcctcc     1020

agcactcagg acacaggcaa gctgccagtc aaatggacag cgcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccgcccg cagtctacga ggtgatgaag     1260

aactgctggc acctggatgc tgccacacgg cccacgtttt tgcagcttcg ggaacagctc     1320

gagcacatca agacccatga gctgcacctg tga                                  1353


<210>  10
<211>  1353
<212>  DNA
<213>  Mus musculus

<400>  10
atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag      300

acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt      420

gatgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gatggactct gcactcgcct catcaaacca aaggtcatgg agggcaccgt ggcggcccag      540

gatgagttct accgcagtgg ctgggcactg aacatgaagg aactgaagct gctacagaca      600

atagggaagg gggagtttgg agatgtgatg ctgggggatt accggggcaa caaagttgca      660

gtcaagtgca tcaagaatga cgcaactgcc caggccttcc tggctgaagc ctccgtcatg      720

acgcaacttc ggcacagcaa cctcgtccag ctgctgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg tggagactgt ctcctcaaat tctcattaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aagacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcctcc     1020

agcactcagg acacaggcaa gctgccagtc aaatggacag cgcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccgcccg cagtctacga ggtgatgaag     1260

aactgctggc acctggatgc tgccacacgg cccacgtttt tgcagcttcg ggaacagctc     1320

gagcacatca agacccatga gctgcacctg tga                                  1353


<210>  11
<211>  1353
<212>  DNA
<213>  Mus musculus

<400>  11
atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag      300

acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt      420

gatgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gatggactct gcactcgcct catcaaacca aaggtcatgg agggcaccgt ggcggcccag      540

gatgagttct accgcagtgg ctgggcactg aacatgaagg aactgaagct gctacagaca      600

atagggaagg gggagtttgg agatgtgatg ctgggggatt accggggcaa caaagttgca      660

gtcaagtgca tcaagaatga cgcaactgcc caggccttcc tggctgaagc ctccgtcatg      720

acgcaacttc ggcacagcaa cctcgtccag ctgctgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg tggagactgt ctcctcaaat tctcattaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aagacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcctcc     1020

agcactcagg acacaggcaa gctgccagtc aaatggacag cgcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccgcccg cagtctacga ggtgatgaag     1260

aactgctggc acctggatgc tgccacacgg cccacgtttt tgcagcttcg ggaacagctc     1320

gagcacatca agacccatga gctgcacctg tga                                  1353


<210>  12
<211>  1353
<212>  DNA
<213>  Mus musculus

<400>  12
atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag      300

acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt      420

gatgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gatggactct gcactcgcct catcaaacca aaggtcatgg agggcaccgt ggcggcccag      540

gatgagttct accgcagtgg ctgggcactg aacatgaagg aactgaagct gctacagaca      600

atagggaagg gggagtttgg agatgtgatg ctgggggatt accggggcaa caaagttgca      660

gtcaagtgca tcaagaatga cgcaactgcc caggccttcc tggctgaagc ctccgtcatg      720

acgcaacttc ggcacagcaa cctcgtccag ctgctgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg tggagactgt ctcctcaaat tctcattaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aagacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcctcc     1020

agcactcagg acacaggcaa gctgccagtc aaatggacag cgcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccgcccg cagtctacga ggtgatgaag     1260

aactgctggc acctggatgc tgccacacgg cccacgtttt tgcagcttcg ggaacagctc     1320

gagcacatca agacccatga gctgcacctg tga                                  1353


<210>  13
<211>  723
<212>  DNA
<213>  Mus musculus

<400>  13
atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag      300

acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt      420

gatgaggagg tgtactttga gaacctcatg cagctggtgg agatcaggac acaaaggttc      480

ggatcagcga agatcccctc gtctacgcat tggaggtgtc tgtctgatcc agacctcact      540

tcctccagca ctcagaacct catgtcggga tgtgtacatt gccgtcaagg tcctggaggc      600

aggcacacag gtccttgctg cttccaacac cggctccacc cgttccagcc aggccatatc      660

tggcatcaaa gacccatagg ttcctctgag ctcactctca tctctggccc gccctgtccc      720

tga                                                                    723


<210>  14
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  15
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  16
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  17
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  18
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  18

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu Ile Arg Thr Gln Arg Phe 
145                 150                 155                 160 


Gly Ser Ala Lys Ile Pro Ser Ser Thr His Trp Arg Cys Leu Ser Asp 
                165                 170                 175     


Pro Asp Leu Thr Ser Ser Ser Thr Gln Asn Leu Met Ser Gly Cys Val 
            180                 185                 190         


His Cys Arg Gln Gly Pro Gly Gly Arg His Thr Gly Pro Cys Cys Phe 
        195                 200                 205             


Gln His Arg Leu His Pro Phe Gln Pro Gly His Ile Trp His Gln Arg 
    210                 215                 220                 


Pro Ile Gly Ser Ser Glu Leu Thr Leu Ile Ser Gly Pro Pro Cys Pro 
225                 230                 235                 240 


<210>  19
<211>  1353
<212>  DNA
<213>  Pan troglodytes

<400>  19
atgtcagcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcactg ccgagcagga cctgcccttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gagactacac gctgtgcgtg      360

agctgcgacg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacagt ggcggcccag      540

gatgagttct accgcagcgg ctgggccctg aacatgaagg agctgaagct gctgcagacc      600

atcgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgct      660

gtcaagtgca ttaagaacga cgccactgcc caggccttcc tggctgaagc ctcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc tcgtggacta cctgcggtct      840

cggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaatttc gtgcatcgag acctggctgc ccgcaatgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgacggc tgcccgcccg cagtctatga ggtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccctccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccacga gctgcacctg tga                                  1353


<210>  20
<211>  450
<212>  PRT
<213>  Pan troglodytes

<400>  20

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  21
<211>  1353
<212>  DNA
<213>  Macaca mulatta

<400>  21
atgtcagcaa tacaggcctc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

cacggcaccg ccgagcaaga cctgcctttc tgcaaaggag acgtgctcac cattgtggcc      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa gcgggagggc gtgaaggcgg gtaccaaact cagcctcatg      240

ccttggttcc acggcaagat cacacgggag caggctgagc ggcttctgta cccgccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccctg gggactacac gctgtgcgtg      360

agctgcgatg gcaaggtgga gcactaccgc atcatgtacc atgccagcaa gctcagcatc      420

gacgaggagg tgtactttga gaatctcatg cagctggtgg agcactacac ctcagacgca      480

gatggactct gtacgcgcct cattaaacca aaggtcatgg agggcacggt ggcggcccag      540

gatgagttct accgcagtgg ctgggccctg aacatgaagg agctgaagct actgcagacc      600

attgggaagg gggagttcgg agacgtgatg ctgggcgatt accgagggaa caaagtcgct      660

gtcaagtgca ttaagaacga cgccaccgcc caggccttcc tggctgaagc ttcagtcatg      720

acgcaactgc ggcatagcaa cctggtgcag ctcctgggcg tgatcgtgga ggagaagggc      780

gggctctaca tcgtcactga gtacatggcc aaggggagcc tcgtggacta cctgcggtct      840

cggggtcggt cagtgctggg cggagactgt ctcctcaagt tctcgctaga tgtctgcgag      900

gccatggaat acctggaggg caacaacttc gtgcatcgag acctggctgc ccgcaacgtg      960

ctggtgtctg aggacaacgt ggccaaggtc agcgactttg gtctcaccaa ggaggcgtcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacag cccctgaggc cctgagagag     1080

aagaaattct ccactaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggatgc ccccgatggc tgcccgcccg cagtctatga ggtcatgaag     1260

aactgctggc acctggacgc cgccatgcgg ccatccttcc tacagctccg agagcagctt     1320

gagcacatca aaacccatga gctgcacctg tga                                  1353


<210>  22
<211>  450
<212>  PRT
<213>  Macaca mulatta

<400>  22

Met Ser Ala Ile Gln Ala Ser Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  23
<211>  1353
<212>  DNA
<213>  Canis familiaris

<400>  23
atgtcagcaa tccaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaatttc       60

catggcactg ccgagcagga ccttcccttc tgcaaaggag acgtgctcac cattgtggcg      120

gtcaccaagg acccaaactg gtacaaagcc aagaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa acgggagggc gtgaaggccg gcaccaagct cagcctcatg      240

ccctggttcc atggcaagat cacgcgggag caggccgagc ggctgctgtg cccgcccgag      300

accggcctgt tcctggtgcg ggagagcacc aactacccgg gggactacac gctgtgcgtg      360

agctgtgacg gcaaggtgga gcactaccgc atcatgtacc acgccagcaa gctcagcatc      420

gacgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac ctcggacgcg      480

gacggactct gtactcgcct catcaagcca aaggtcatgg agggcacggt ggccgcccag      540

gatgagttct tccgcagcgg ctgggcactg aacatgaagg acctgaagct gctgcagacc      600

attgggaagg gggagtttgg agacgtgatg ctaggcgatt accgagggaa caaggttgct      660

gtcaagtgca ttaaaaatga cgccactgcc caggcctttc tggctgaagc ctctgtgatg      720

acgcaacttc ggcatagcaa cctggtacag cttctgggtg tgatcgtgga agagaagggc      780

gggctgtaca ttgtcacgga gtacatggcc aagggaagcc tggtggacta tctgcggtca      840

aggggtcgat cggtgctggg cggagactgt ctcctcaagt tctcactaga tgtctgtgag      900

gccatggaat acctggaggg caacaacttc gtgcaccggg atctggctgc ccgcaacgtg      960

ctggtgtctg aagacaacgt ggccaaggtc agcgactttg gcctcaccaa ggaggcctcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacgg ccccggaggc cctgagagag     1080

aagaaattct ccaccaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggacgc ccccgacggc tgcccacctg cggtctacga ggtcatgaag     1260

aactgctggc acctggatgc tgccacaagg ccctccttcc tgcagctccg ggagcagctc     1320

gagcacatca aaacccacga gttgcacctg tga                                  1353


<210>  24
<211>  1353
<212>  DNA
<213>  Canis familiaris

<400>  24
atgtcagcaa tccaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaatttc       60

catggcactg ccgagcagga ccttcccttc tgcaaaggag acgtgctcac cattgtggcg      120

gtcaccaagg acccaaactg gtacaaagcc aagaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa acgggagggc gtgaaggccg gcaccaagct cagcctcatg      240

ccctggttcc atggcaagat cacgcgggag caggccgagc ggctgctgtg cccgcccgag      300

accggcctgt tcctggtgcg ggagagcacc aactacccgg gggactacac gctgtgcgtg      360

agctgtgacg gcaaggtgga gcactaccgc atcatgtacc acgccagcaa gctcagcatc      420

gacgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac ctcggacgcg      480

gacggactct gtactcgcct catcaagcca aaggtcatgg agggcacggt ggccgcccag      540

gatgagttct tccgcagcgg ctgggcactg aacatgaagg acctgaagct gctgcagacc      600

attgggaagg gggagtttgg agacgtgatg ctaggcgatt accgagggaa caaggttgct      660

gtcaagtgca ttaaaaatga cgccactgcc caggcctttc tggctgaagc ctctgtgatg      720

acgcaacttc ggcatagcaa cctggtacag cttctgggtg tgatcgtgga agagaagggc      780

gggctgtaca ttgtcacgga gtacatggcc aagggaagcc tggtggacta tctgcggtca      840

aggggtcgat cggtgctggg cggagactgt ctcctcaagt tctcactaga tgtctgtgag      900

gccatggaat acctggaggg caacaacttc gtgcaccggg atctggctgc ccgcaacgtg      960

ctggtgtctg aagacaacgt ggccaaggtc agcgactttg gcctcaccaa ggaggcctcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacgg ccccggaggc cctgagagag     1080

aagaaattct ccaccaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggacgc ccccgacggc tgcccacctg cggtctacga ggtcatgaag     1260

aactgctggc acctggatgc tgccacaagg ccctccttcc tgcagctccg ggagcagctc     1320

gagcacatca aaacccacga gttgcacctg tga                                  1353


<210>  25
<211>  1353
<212>  DNA
<213>  Canis familiaris

<400>  25
atgtcagcaa tccaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaatttc       60

catggcactg ccgagcagga ccttcccttc tgcaaaggag acgtgctcac cattgtggcg      120

gtcaccaagg acccaaactg gtacaaagcc aagaacaagg tgggccgtga gggcatcatc      180

ccagccaact acgtccagaa acgggagggc gtgaaggccg gcaccaagct cagcctcatg      240

ccctggttcc atggcaagat cacgcgggag caggccgagc ggctgctgtg cccgcccgag      300

accggcctgt tcctggtgcg ggagagcacc aactacccgg gggactacac gctgtgcgtg      360

agctgtgacg gcaaggtgga gcactaccgc atcatgtacc acgccagcaa gctcagcatc      420

gacgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac ctcggacgcg      480

gacggactct gtactcgcct catcaagcca aaggtcatgg agggcacggt ggccgcccag      540

gatgagttct tccgcagcgg ctgggcactg aacatgaagg acctgaagct gctgcagacc      600

attgggaagg gggagtttgg agacgtgatg ctaggcgatt accgagggaa caaggttgct      660

gtcaagtgca ttaaaaatga cgccactgcc caggcctttc tggctgaagc ctctgtgatg      720

acgcaacttc ggcatagcaa cctggtacag cttctgggtg tgatcgtgga agagaagggc      780

gggctgtaca ttgtcacgga gtacatggcc aagggaagcc tggtggacta tctgcggtca      840

aggggtcgat cggtgctggg cggagactgt ctcctcaagt tctcactaga tgtctgtgag      900

gccatggaat acctggaggg caacaacttc gtgcaccggg atctggctgc ccgcaacgtg      960

ctggtgtctg aagacaacgt ggccaaggtc agcgactttg gcctcaccaa ggaggcctcc     1020

agcacccagg acacgggcaa gctgccagtc aagtggacgg ccccggaggc cctgagagag     1080

aagaaattct ccaccaagtc tgacgtgtgg agtttcggaa tccttctctg ggaaatctac     1140

tcctttgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggag     1200

aagggctaca agatggacgc ccccgacggc tgcccacctg cggtctacga ggtcatgaag     1260

aactgctggc acctggatgc tgccacaagg ccctccttcc tgcagctccg ggagcagctc     1320

gagcacatca aaacccacga gttgcacctg tga                                  1353


<210>  26
<211>  450
<212>  PRT
<213>  Canis familiaris

<400>  26

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Cys Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Phe Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  27
<211>  450
<212>  PRT
<213>  Canis familiaris

<400>  27

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Cys Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Phe Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  28
<211>  450
<212>  PRT
<213>  Canis familiaris

<400>  28

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Cys Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Phe Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  29
<211>  1353
<212>  DNA
<213>  Bos taurus

<400>  29
atgtcagcaa ttcaggctgc ctggccatcc ggtacagaat gtattgccaa gtacaacttt       60

cacggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac cattgtggct      120

gtcaccaagg accccaattg gtacaaagcc aagaacaagg tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgggagggt gtgaaggcag gcaccaagct cagcctcatg      240

ccctggttcc atggcaagat cacgcgggaa caggcagagc ggctcctgtg cccaccggag      300

acaggcctgt tcctggtgcg ggagagcacc aactaccccg gggactacac gctgtgcgtg      360

agctgtgatg gcaaggtgga gcattaccgc atcatgtacc acgccagcaa gctcagcatc      420

gatgaagagg tgtactttga gaacctcatg cagctggtgg agcactacac ctcagatgca      480

gatggcctct gtactcgcct catcaagcca aaggtcatgg agggcaccgt ggccgcccag      540

gatgagttct tccgcagtgg ctgggcgctg aacatgaagg acctgaagct gctgcagacc      600

atagggaagg gggagtttgg agacgtgatg ctgggtgact accgagggaa caaagtcgct      660

gtcaagtgca ttaagaacga tgccactgca caggccttcc tggctgaagc ctccgtcatg      720

acgcaactcc ggcatagcaa cctggtacag cttctgggcg tgatcgtaga ggagaagagc      780

gggctgtaca tcgttaccga gtacatggcc aaggggagtc tagtggacta cctgcggtct      840

cggggtcggt cggtgcttgg cggagactgt ctcctcaagt tctcactaga cgtctgtgag      900

gccatggaat acctggaggg caacaacttc gtgcatcggg atctggctgc ccgcaacgtg      960

ctggtgtctg aggacaatgt ggccaaggtc agcgacttcg gcctcaccaa ggaggcctcc     1020

agcacccagg acacgggcaa gctgccggtc aagtggacag cccccgaggc cctaagagag     1080

aagaaattct ccaccaagtc tgatgtgtgg agtttcggga tccttctctg ggaaatctac     1140

tctttcgggc gagtgcctta tccaagaatt cccctgaagg acgtcgtccc gcgggtggag     1200

aagggctaca agatggatgc ccctgacggc tgcccacctg cagtctacga ggtcatgaag     1260

aactgctggc acctggatgc cgccacgcgg ccctccttcc tgcagctccg cgagcagctc     1320

gagcgcatca agacccacga gctgcacctg tga                                  1353


<210>  30
<211>  450
<212>  PRT
<213>  Bos taurus

<400>  30

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Cys Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Phe Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Ser Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu Arg Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  31
<211>  1353
<212>  DNA
<213>  Rattus norvegicus

<400>  31
atgtcggcta tacaggcctc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ccgagcaaga ccttcccttc tgcaaaggag atgtgctcac cattgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaagct cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggcggagc ggcttctcta cccaccagag      300

acaggcctgt tcctggtgcg ggaaagcacc aactaccctg gggactacac actgtgtgtg      360

agctgtgaag gcaaggtgga gcactaccgc atcatgtatc acgcgagcaa gctgagcatt      420

gatgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gacggactct gcactcgcct catcaaacca aaggtcatgg agggcacagt ggcggcccaa      540

gatgaattct accgcagtgg ctgggccctg aacatgaagg aactgaagct gctacagacg      600

ataggaaagg gggagtttgg agatgtgatg ctgggggatt accgaggcaa caaagttgca      660

gtcaagtgca ttaagaatga tgctacagcc caggccttcc tggctgaagc ctctgtcatg      720

acgcagcttc ggcacagcaa cctagtccag ctactgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg cggagactgt ctcctcaaat tctcactaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aggacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcttcc     1020

agcactcagg acacaggcaa actgccagtc aagtggacag ctcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccacccg cagtctatga tgttatgaag     1260

aactgctggc acctggatgc tgccacgcgg cccacctttc tgcagcttcg agagcagctc     1320

gagcacatca gaacccatga gctgcacctg tga                                  1353


<210>  32
<211>  1353
<212>  DNA
<213>  Rattus norvegicus

<400>  32
atgtcggcta tacaggcctc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ccgagcaaga ccttcccttc tgcaaaggag atgtgctcac cattgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaagct cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggcggagc ggcttctcta cccaccagag      300

acaggcctgt tcctggtgcg ggaaagcacc aactaccctg gggactacac actgtgtgtg      360

agctgtgaag gcaaggtgga gcactaccgc atcatgtatc acgcgagcaa gctgagcatt      420

gatgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gacggactct gcactcgcct catcaaacca aaggtcatgg agggcacagt ggcggcccaa      540

gatgaattct accgcagtgg ctgggccctg aacatgaagg aactgaagct gctacagacg      600

ataggaaagg gggagtttgg agatgtgatg ctgggggatt accgaggcaa caaagttgca      660

gtcaagtgca ttaagaatga tgctacagcc caggccttcc tggctgaagc ctctgtcatg      720

acgcagcttc ggcacagcaa cctagtccag ctactgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg cggagactgt ctcctcaaat tctcactaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aggacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcttcc     1020

agcactcagg acacaggcaa actgccagtc aagtggacag ctcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccacccg cagtctatga tgttatgaag     1260

aactgctggc acctggatgc tgccacgcgg cccacctttc tgcagcttcg agagcagctc     1320

gagcacatca gaacccatga gctgcacctg tga                                  1353


<210>  33
<211>  1353
<212>  DNA
<213>  Rattus norvegicus

<400>  33
atgtcggcta tacaggcctc ctggccatcc ggtacagaat gtattgccaa gtacaacttc       60

catggcactg ccgagcaaga ccttcccttc tgcaaaggag atgtgctcac cattgtggct      120

gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc      180

ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaagct cagccttatg      240

ccctggttcc acggcaagat cacacgggag caggcggagc ggcttctcta cccaccagag      300

acaggcctgt tcctggtgcg ggaaagcacc aactaccctg gggactacac actgtgtgtg      360

agctgtgaag gcaaggtgga gcactaccgc atcatgtatc acgcgagcaa gctgagcatt      420

gatgaggagg tgtacttcga gaacctcatg cagctggtgg agcactacac cacagatgcc      480

gacggactct gcactcgcct catcaaacca aaggtcatgg agggcacagt ggcggcccaa      540

gatgaattct accgcagtgg ctgggccctg aacatgaagg aactgaagct gctacagacg      600

ataggaaagg gggagtttgg agatgtgatg ctgggggatt accgaggcaa caaagttgca      660

gtcaagtgca ttaagaatga tgctacagcc caggccttcc tggctgaagc ctctgtcatg      720

acgcagcttc ggcacagcaa cctagtccag ctactgggtg tgattgtgga ggagaagggt      780

gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca      840

cgtggtcgtt cggtgctagg cggagactgt ctcctcaaat tctcactaga cgtctgtgaa      900

gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg      960

ctggtgtctg aggacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcttcc     1020

agcactcagg acacaggcaa actgccagtc aagtggacag ctcctgaagc cttgagagag     1080

aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat     1140

tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa     1200

aagggctata agatggacgc tccggatggc tgcccacccg cagtctatga tgttatgaag     1260

aactgctggc acctggatgc tgccacgcgg cccacctttc tgcagcttcg agagcagctc     1320

gagcacatca gaacccatga gctgcacctg tga                                  1353


<210>  34
<211>  450
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Met Ser Ala Ile Gln Ala Ser Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Asp Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Arg Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  35
<211>  450
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Met Ser Ala Ile Gln Ala Ser Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Asp Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Arg Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  36
<211>  450
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Met Ser Ala Ile Gln Ala Ser Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Asp Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Arg Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  37
<211>  1353
<212>  DNA
<213>  Gallus gallus

<400>  37
atgtcaggga tgcaggccgt ttggccatcc ggtacagaat gtatcgccaa gtacaacttc       60

cacggtacgg ccgagcagga cctgccgttc agcaagggag acgtcctcac catcgtcgcc      120

gtcaccaagg accccaactg gtacaaggcg aagaacaagg tgggccggga gggcatcatc      180

cccgctaact acgtgcagaa gagggaagga gtgaaggctg gcatcaagct cagcctcatg      240

ccgtggttcc atgggaagat cacacgggag caggcagaga ggctgctgta cccacccgag      300

acggggctgt tcctggtgcg ggagagcacc aactaccccg gggactacac cctgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatttact cctccagcaa gctgagcatc      420

gacgaggagg tctacttcga gaacctgatg cagcttgtgg agcattacac cacggacgcc      480

gacggcctct gctcgcgcct catcaaaccg aaggtgatgg aggggacggt ggcagctcag      540

gatgagttct cccgcagtgg ctgggccctc aacatgaagg acctcaagct gctgcaaatc      600

attggcaaag gggaatttgg agatgtgatg ctgggtgatt accgggggaa caaagtcgcc      660

gtcaagtgca ttaaaaatga cgccacagcg caggctttcc tggcagaagc gtccgtgatg      720

acgcagctcc gacacagcaa cctggtgcag ctgctggggg tgatcgtgga ggagaagagc      780

ggcctctata ttgtcactga gtatatggcc aagggcagcc tagtagatta cctgcggtcg      840

cgtgggaggt cggtcctagg cggagactgc ctgctcaagt tttccttaga tgtctgtgaa      900

gccatggagt acctggaagc caacaacttc gtccaccggg acctggcggc gaggaatgtg      960

ttggtctcag aggacaacat tgccaaggtc agcgatttcg ggctgacaaa ggaagcgtcg     1020

tccactcagg acacggggaa gctgcctgtg aagtggacgg cacccgaagc acttagagaa     1080

aagaaattct ccaccaaatc ggacgtgtgg agcttcggga tcctcctctg ggaaatctac     1140

tccttcgggc gagtgcctta tccgagaatc cccctgaagg acgtggtgcc ccgggtggag     1200

aagggctata agatggaccc tccagacggc tgcccggcca tcgtctacga ggtgatgaag     1260

aagtgctgga cgctggaccc agggcaccgg ccgtccttcc accagctccg tgaacagcta     1320

gtgcatatca aagagaagga gctctacctg tga                                  1353


<210>  38
<211>  1353
<212>  DNA
<213>  Gallus gallus

<400>  38
atgtcaggga tgcaggccgt ttggccatcc ggtacagaat gtatcgccaa gtacaacttc       60

cacggtacgg ccgagcagga cctgccgttc agcaagggag acgtcctcac catcgtcgcc      120

gtcaccaagg accccaactg gtacaaggcg aagaacaagg tgggccggga gggcatcatc      180

cccgctaact acgtgcagaa gagggaagga gtgaaggctg gcatcaagct cagcctcatg      240

ccgtggttcc atgggaagat cacacgggag caggcagaga ggctgctgta cccacccgag      300

acggggctgt tcctggtgcg ggagagcacc aactaccctg gggactacac cctgtgtgtg      360

agctgtgagg gcaaggtgga gcactaccgc atcatttact cctccagcaa gctgagcatc      420

gatgaggagg tctacttcga gaacctgatg cagcttgtgg agcattacac cacggacgcc      480

gacgggctct gcacgcgcct catcaaaccg aaggtgatgg aggggacggt ggcagctcag      540

gacgagttct cccgcagtgg ctgggccctc aacatgaagg acctcaagct gctgcaaatc      600

attggcaaag gggaatttgg agatgtgatg ctgggtgatt accgggggaa caaagtcgcc      660

gtcaagtgca ttaaaaatga cgccacagcg caggctttcc tggcagaagc atccgtgatg      720

acgcagctcc gacacagcaa cctggtgcag ctgctggggg tgatcgtgga ggagaagagc      780

ggcctctaca ttgtcactga gtatatggcc aagggcagcc tagtagatta cctgcggtcg      840

cgtgggaggt cggtcctagg cgcagactgc ctgctcaagt tttccttaga tgtctgtgaa      900

gccatggagt acctggaagc caacaacttc gtccaccggg acctggcggc gaggaatgtg      960

ttggtctcag aggacaacat tgccaaggtc agcgatttcg ggctgacaaa ggaagcgtcg     1020

tccactcagg acacggggaa gctgcctgtg aagtggacgg cacccgaagc acttagagaa     1080

aagaaattct ccaccaaatc ggacgtgtgg agcttcggga tcctcctctg ggaaatctac     1140

tccttcgggc gagtgcctta tccgagaatc cccctgaagg acgtggtgcc ccgggtggag     1200

aagggctata agatggaccc tccagacggc tgcccggcca tcgtctacga ggtgatgaag     1260

aagtgctgga cgctggaccc agggcaccgg ccgtccttcc accagctccg tgaacagcta     1320

gtgcatatca aagagaagga gctctacctg tga                                  1353


<210>  39
<211>  450
<212>  PRT
<213>  Gallus gallus

<400>  39

Met Ser Gly Met Gln Ala Val Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Ser Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Ile Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Ile Tyr Ser Ser Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Ser Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Ile Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Ser Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Ala 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Ala Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Ile Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Pro Pro Asp Gly Cys Pro Ala Ile Val Tyr 
                405                 410                 415     


Glu Val Met Lys Lys Cys Trp Thr Leu Asp Pro Gly His Arg Pro Ser 
            420                 425                 430         


Phe His Gln Leu Arg Glu Gln Leu Val His Ile Lys Glu Lys Glu Leu 
        435                 440                 445             


Tyr Leu 
    450 


<210>  40
<211>  450
<212>  PRT
<213>  Gallus gallus

<400>  40

Met Ser Gly Met Gln Ala Val Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Ser Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Ile Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Ile Tyr Ser Ser Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Ser Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Ser Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Asp Leu Lys Leu Leu Gln Ile Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Ser Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Ala Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Ile Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Pro Pro Asp Gly Cys Pro Ala Ile Val Tyr 
                405                 410                 415     


Glu Val Met Lys Lys Cys Trp Thr Leu Asp Pro Gly His Arg Pro Ser 
            420                 425                 430         


Phe His Gln Leu Arg Glu Gln Leu Val His Ile Lys Glu Lys Glu Leu 
        435                 440                 445             


Tyr Leu 
    450 


<210>  41
<211>  1353
<212>  DNA
<213>  Xenopus tropicalis

<400>  41
atgtcagtgg tgcaggcccc ttggcaagct ggcacagaat gcattgctaa ctatgacttc       60

cagggtaaag ctgagcagga cctgcatttt agtaaaggtg aagtgctgac cattgtggct      120

gtgacaaagg atccaaattg gtacaaggca aaaaacaaag tagggagagt gggattcatc      180

cctgcaaact atgtccaaaa gagagaagga gtgaaatctg gaaccaaact cagccttatg      240

ccgtggtttc atggcaagat aacccgagag caggctgagc gtctcttgta tccacctgaa      300

acgggcttat tccttgtacg ggagagtaca aactaccctg gagattatac tctgtgtgtg      360

agctgtgaag ggaaagtgga gcattaccgc attatctatt cttctggcaa gctgagcatt      420

gatgaagagg aatactttga aaatctcatg cagctggtgg agcactatac caatgatgca      480

gatggcctgt gcacaaattt gatgaagccc aaattggtgg agggaactgt agctgcccag      540

gatgaattct cccggagtgg ctgggccctc aagatgagag atctcaaact gctgcacacc      600

attggcaagg gggaatttgg agatgtcatg cttggtgaac atcaaggagt gaaagtagct      660

gtgaaatgta tcaagaacga tgccacggca caagcatttg tagcagaagc tatggtgatg      720

acgcaattgc aacataacaa tcttgtgcag ctacttggag tgattgttga agataaaagt      780

ggtttgttta tcgtcacaga atttatggca aagggaagcc tagtggatta tttgaggtct      840

cggggaaggt cagtgctagg tggcgaatgt ctactaaagt tctcactgga tgtatcagaa      900

ggtatggcat atcttgagag taataacttt gtgcacagag atctagcggc acgcaatgtg      960

ttggtatcag aagaaaatat tgctaaggtc agtgactttg gactcaccaa ggaagcatcc     1020

gccatacagg acacaagcaa actgcctgtt aagtggacag caccagaagc gttgcgggat     1080

aagctatttt caaccaagtc tgatgtttgg agctttggaa ttctgttatg ggagatctat     1140

tcctttgggc gagtgcctta tccacgcatt gcccttaaag atgtggtacc aaaggtggag     1200

aatgggtata aaatggacgc acccgatgga tgtcctcctg ttgtatatga tttgatgaag     1260

cagtgttggc atctggaccc aaaacagcga cccactttta ggaatctgcg agaacagcta     1320

gagcatatca aagcgaagga actgtttcac tga                                  1353


<210>  42
<211>  450
<212>  PRT
<213>  Xenopus tropicalis

<400>  42

Met Ser Val Val Gln Ala Pro Trp Gln Ala Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Asn Tyr Asp Phe Gln Gly Lys Ala Glu Gln Asp Leu His Phe Ser Lys 
            20                  25                  30          


Gly Glu Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Val Gly Phe Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ser Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Ile Tyr Ser Ser Gly Lys Leu Ser Ile Asp Glu Glu Glu 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Asn Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Asn Leu Met Lys Pro Lys Leu Val Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Ser Arg Ser Gly Trp Ala Leu Lys Met 
            180                 185                 190         


Arg Asp Leu Lys Leu Leu His Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Glu His Gln Gly Val Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Val Ala Glu Ala Met Val Met 
225                 230                 235                 240 


Thr Gln Leu Gln His Asn Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Asp Lys Ser Gly Leu Phe Ile Val Thr Glu Phe Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Glu Cys Leu Leu Lys Phe Ser Leu Asp Val Ser Glu Gly Met Ala Tyr 
    290                 295                 300                 


Leu Glu Ser Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Glu Asn Ile Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ala Ile Gln Asp Thr Ser Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Asp Lys Leu Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Ala Leu Lys Asp Val Val Pro Lys Val Glu 
385                 390                 395                 400 


Asn Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Val Val Tyr 
                405                 410                 415     


Asp Leu Met Lys Gln Cys Trp His Leu Asp Pro Lys Gln Arg Pro Thr 
            420                 425                 430         


Phe Arg Asn Leu Arg Glu Gln Leu Glu His Ile Lys Ala Lys Glu Leu 
        435                 440                 445             


Phe His 
    450 


<210>  43
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  43
atgtctgata acggagaact ggaagataag cctccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagaccct ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cagaagagaa aaagcccagg cataaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct aaagttctac gactccaaca cagtgaagca gaaatatctg      420

agctttactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaatgccaag      480

ggaacagaag cacccgcagt agtgacagag gaggaggatg atgatgaaga gactgctcct      540

cccgttattg ccccgcgacc ggatcatacg aaatcaattt acacacggtc tgtaattgac      600

cctgttcctg caccagttgg tgattcacat gttgatggtg ctgccaagtc tttagacaaa      660

cagaaaaaga agactaagat gacagatgaa gagattatgg agaaattaag aactatcgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ctgggacagg aggttgctat caaacaaatt      840

aatttacaga aacagccaaa gaaggaactg atcattaacg agattctggt gatgaaagaa      900

ttgaaaaatc ccaacatcgt taactttttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggggggtca ctcactgatg tggtaacaga aacgtgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tacttttggg aatggaagga     1140

tctgttaagc tcactgactt tggtttctgt gcccagatca cccctgagca gagcaaacgc     1200

agtaccatgg tcggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccctaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagaacttc agaatccaga gaaactttcc ccaatatttc gggatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcctg     1500

aaactggcca aaccgttatc tagcttgaca ccactgatca tggcagctaa agaagcaatg     1560

aagagtaacc gttaa                                                      1575


<210>  44
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  44
atgtctgata acggagaact ggaagataag cctccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagaccct ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cagaagagaa aaagcccagg cataaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct aaagttctac gactccaaca cagtgaagca gaaatatctg      420

agctttactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaatgccaag      480

ggaacagaag cacccgcagt agtgacagag gaggaggatg atgatgaaga gactgctcct      540

cccgttattg ccccgcgacc ggatcatacg aaatcaattt acacacggtc tgtaattgac      600

cctgttcctg caccagttgg tgattcacat gttgatggtg ctgccaagtc tttagacaaa      660

cagaaaaaga agactaagat gacagatgaa gagattatgg agaaattaag aactatcgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ctgggacagg aggttgctat caaacaaatt      840

aatttacaga aacagccaaa gaaggaactg atcattaacg agattctggt gatgaaagaa      900

ttgaaaaatc ccaacatcgt taactttttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggggggtca ctcactgatg tggtaacaga aacgtgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tacttttggg aatggaagga     1140

tctgttaagc tcactgactt tggtttctgt gcccagatca cccctgagca gagcaaacgc     1200

agtaccatgg tcggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccctaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagaacttc agaatccaga gaaactttcc ccaatatttc gggatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcctg     1500

aaactggcca aaccgttatc tagcttgaca ccactgatca tggcagctaa agaagcaatg     1560

aagagtaacc gttaa                                                      1575


<210>  45
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  45
atgtctgata acggagaact ggaagataag cctccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagaccct ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cagaagagaa aaagcccagg cataaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct aaagttctac gactccaaca cagtgaagca gaaatatctg      420

agctttactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaatgccaag      480

ggaacagaag cacccgcagt agtgacagag gaggaggatg atgatgaaga gactgctcct      540

cccgttattg ccccgcgacc ggatcatacg aaatcaattt acacacggtc tgtaattgac      600

cctgttcctg caccagttgg tgattcacat gttgatggtg ctgccaagtc tttagacaaa      660

cagaaaaaga agactaagat gacagatgaa gagattatgg agaaattaag aactatcgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ctgggacagg aggttgctat caaacaaatt      840

aatttacaga aacagccaaa gaaggaactg atcattaacg agattctggt gatgaaagaa      900

ttgaaaaatc ccaacatcgt taactttttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggggggtca ctcactgatg tggtaacaga aacgtgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tacttttggg aatggaagga     1140

tctgttaagc tcactgactt tggtttctgt gcccagatca cccctgagca gagcaaacgc     1200

agtaccatgg tcggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccctaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagaacttc agaatccaga gaaactttcc ccaatatttc gggatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcctg     1500

aaactggcca aaccgttatc tagcttgaca ccactgatca tggcagctaa agaagcaatg     1560

aagagtaacc gttaa                                                      1575


<210>  46
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  47
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  48
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  49
<211>  1575
<212>  DNA
<213>  Pan troglodytes

<400>  49
atgtctgata acggagaact ggaagacaag cctccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagaccct ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cagaagagaa aaagcccagg cataaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct aaagttctac gactccaaca cagtgaagca gaaatatctg      420

agctttactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaatgccaag      480

ggaacagaag cacccgcagt agtgacagag gaggaggatg atgatgaaga gactgctcct      540

cccgttattg ccccgcgacc ggatcatacg aaatcaattt acacacggtc tgtaattgac      600

cctgttcctg caccagttgg tgattcacat gttgatggtg ctgccaagtc tttagacaaa      660

cagaaaaaga agactaagat gacagatgaa gagattatgg agaaattaag aactatcgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ttgggacagg aggttgctat caaacaaatt      840

aatttacaga aacagccaaa gaaggaactg atcattaacg agattctggt gatgaaagaa      900

ttgaaaaatc ccaacatcgt taactttttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggggggtca ctcactgatg tggtaacaga aacctgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tacttttggg aatggaagga     1140

tcggttaaac tcactgactt tggtttctgt gcccagatca cccctgagca gagcaaacgc     1200

agtaccatgg tcggaacgcc atactggatg gcaccagagg tggttacacg gaaagcgtat     1260

ggccctaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagaacttc agaatccaga gaaactttcc ccaatatttc gggatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcctg     1500

aaactggcca aaccgttatc tagcttgaca ccactgatca tggcagctaa agaagcaatg     1560

aagagtaacc gttaa                                                      1575


<210>  50
<211>  524
<212>  PRT
<213>  Pan troglodytes

<400>  50

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  51
<211>  1575
<212>  DNA
<213>  Macaca mulatta

<400>  51
atgtctgata acggagaact ggaagacaag cccccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagacccc ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cggaggagaa gaagcccagg cacaaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gaacacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaac atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct caagttctac gactccaaca cagtgaagca gaagtatctg      420

agctttactc ctccggagaa agatggcttc ccttctggaa caccagcact gaacgccaag      480

ggaacagaaa cacccgcagt agtgacagag gaagatgatg atgatgaaga gactgctcct      540

cctgttattg ccccacgacc agatcatacg aaatcaattt acacacggtc tgtaattgac      600

cccgttcctg caccagttgg tgattcaagt gttgatggtg gtgccaagtc ttcagacaaa      660

cagaaaaaga agactaaaat gacagatgaa gaaattatgg agaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ttgggacagg aggttgctat caaacagatt      840

aatttacaga aacagccaaa gaaggaattg atcattaatg agattctggt gatgaaagaa      900

ttaaaaaatc ccaacatagt taacttcttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggtggatcg ctcactgatg tggtaacaga aacctgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgcttgc aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agcgacaatg tccttttggg aatggaagga     1140

tcggttaagc tcactgactt tggtttctgt gcccagatca cccccgagca gagcaaacgc     1200

agtaccatgg tcggaacccc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccccaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagagcttc agaatccaga gaaactttcc ccaatatttc gagatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcttg     1500

aaactggcca aaccattatc tagcttgaca ccactgatca tggcagctaa agaagcgatg     1560

aagagtaacc gttaa                                                      1575


<210>  52
<211>  1575
<212>  DNA
<213>  Macaca mulatta

<400>  52
atgtctgata acggagaact ggaagacaag cccccagcac ctcctgtgcg aatgagcagc       60

accatcttta gcactggagg caaagacccc ttgtcagcca atcacagttt gaaacctttg      120

ccctctgttc cggaggagaa gaagcccagg cacaaaatca tctccatatt ctcaggcaca      180

gagaaaggaa gtaaaaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gaacacacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactaca gacctccaac atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtcct caagttctac gactccaaca cagtgaagca gaagtatctg      420

agctttactc ctccggagaa agatggcttc ccttctggaa caccagcact gaacgccaag      480

ggaacagaaa cacccgcagt agtgacagag gaagatgatg atgatgaaga gactgctcct      540

cctgttattg ccccacgacc agatcatacg aaatcaattt acacacggtc tgtaattgac      600

cccgttcctg caccagttgg tgattcaagt gttgatggtg gtgccaagtc ttcagacaaa      660

cagaaaaaga agactaaaat gacagatgaa gaaattatgg agaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aggggcttct      780

ggtacagttt tcactgctac tgacgttgca ttgggacagg aggttgctat caaacagatt      840

aatttacaga aacagccaaa gaaggaattg atcattaatg agattctggt gatgaaagaa      900

ttaaaaaatc caaacatagt taacttcttg gacagttacc tggtaggaga tgaattgttt      960

gtggtcatgg aataccttgc tggtggatcg ctcactgatg tggtaacaga aacctgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtctgc aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agcgacaatg tccttttggg aatggaagga     1140

tcggttaagc tcactgactt tggtttctgt gcccagatca cccccgagca gagcaaacgc     1200

agtaccatgg tcggaacccc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccccaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc     1380

ccagagcttc agaatccaga gaaactttcc ccaatatttc gagatttctt aaatcgatgt     1440

ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcttg     1500

aaactggcca aaccattatc tagcttgaca ccactgatca tggcagctaa agaagcgatg     1560

aagagtaacc gttaa                                                      1575


<210>  53
<211>  524
<212>  PRT
<213>  Macaca mulatta

<400>  53

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Thr Pro Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Ser Val Asp Gly Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  54
<211>  524
<212>  PRT
<213>  Macaca mulatta

<400>  54

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys 
145                 150                 155                 160 


Gly Thr Glu Thr Pro Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Ser Val Asp Gly Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  55
<211>  1575
<212>  DNA
<213>  Canis familiaris

<400>  55
atgtccgata acggagaact ggaagacaag cctccagcac ctcctgtgcg aatgagcagt       60

accattttta gcactggagg caaagatcct ttgtcagcca atcacagttt gaaacctttg      120

ccctccgttc cagaggaaaa aaagcccagg aataaaatca tctctatatt ctccggcaca      180

gagaaaggaa gtaagaagaa agaaaaggaa cggccagaaa tttctcctcc atctgatttt      240

gagcatacca tccatgttgg ctttgatgcg gttacgggag aatttactgg catgccagaa      300

cagtgggctc gattattaca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggctgtgc tggatgtctt aaagttctat gactccaaca cagtgaagca gaaatacctg      420

agctttactc ctactgagaa agatggcttc ccttctggaa cacccacact gagtgccaag      480

ggttcagaaa cagcagcagt agtagcagag gaagatgatg atgatgaaga ggctgctcct      540

cctgttattg ccccacgacc ggatcataca aaatcaattt atacacggtc tgtaattgac      600

cctattcctg caccagttgg tgattctaat gttgatagcg gtgccaagtc ttctgacaaa      660

cagaaaaaga agaccaaaat gacagatgaa gagattatgg aaaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatacaca agatacgaaa aaattgggca aggggcttct      780

ggtacagttt tcactgctac tgatgtggca ttgggacagg aggttgctat caaacagatt      840

aatttacaga aacagccaaa gaaggaatta atcattaatg agattctggt gatgaaagaa      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tgatgggaga cgaattgttt      960

gtagtaatgg agtaccttgc cgggggatca cttactgatg ttgtaacaga aacctgcatg     1020

gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaacg tgcttttggg gatggaagga     1140

tcagttaaac ttactgactt tgggttctgt gcccagatca cccctgagca gagcaagaga     1200

agtaccatgg ttggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccctaaag tggacatatg gtctctgggt atcatggcta ttgagatgat agaaggagag     1320

ccgccatacc tcaatgaaaa tcccttgagg gccttgtacc tgatagcaac taatggaact     1380

ccagaacttc agaatccaga gaagctttcc ccaatatttc gggatttctt aaaccgttgt     1440

ttggagatgg atgtggagaa aaggggttcg gccaaagaat tattacagca tcccttcctg     1500

aaactggcca aacctttgtc cagcttgaca ccactgatca tggcagctaa agaagcaatg     1560

aagagtaacc gttag                                                      1575


<210>  56
<211>  524
<212>  PRT
<213>  Canis familiaris

<400>  56

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Thr Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Thr Leu Ser Ala Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ala Ala Val Val Ala Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Glu Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Met Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  57
<211>  1575
<212>  DNA
<213>  Bos taurus

<400>  57
atgtctgata acggagaact ggaagacaag cctccggcgc ccccagtgcg aatgagcagt       60

actattttta gcactggagg caaagaccct ttatcagcca atcacagttt gaaacctttg      120

ccttccgttc cagaggaaaa aaagcccagg aataaaatca tctctatatt ttcaagcaca      180

gagaaaggaa gtaagaagaa agagaaggaa aggccagaaa tttctcctcc gtctgatttt      240

gagcatacca tccatgttgg ctttgatgct gttactggag aattcactgg catgccagaa      300

cagtgggctc gattactgca gacctccaat atcaccaaac tagagcaaaa gaagaatcct      360

caggcagtgc tggacgtctt gaagttctat gactctaata cagtgaagca gaaatatctg      420

agctttactc ctcctgagaa agatggcttc ccttctggaa caccagcact gaataccaag      480

ggatcggaaa catcagcagt agtaacagag gaagatgacg atgatgaaga ggctcttcct      540

cctgttattg ctccacgacc agatcataca aaatcaattt atacacgatc tgtaattgat      600

cctattcctg caccagttgg tgattctaat gttgatggtg gtgccaagac ttcagacaaa      660

cagaaaaaga aggccaaaat gacagatgaa gagattatgg agaaattaag aactattgta      720

agcataggtg accctaagaa aaaatacaca agatatgaaa aaattgggca aggggcttct      780

ggcacagttt tcactgctac agatgtggca ttgggacaag aggttgctat taagcagatt      840

aatttacaga aacagccaaa gaaggaattg atcattaatg agattctggt gatgaaagaa      900

ttaaagaatc ccaacatagt taatttcttg gacagttacc tggtgggaga tgaattgttt      960

gtggtcatgg agtacctggc cggaggatcc cttactgatg ttgtcacaga gacatgcatg     1020

gatgaagccc agatagctgc tgtgtgcaga gagtgtttac aggcattgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg catggaagga     1140

tctgttaaac ttactgactt tggtttctgt gcccagatca cccctgagca gagtaagcgg     1200

agtaccatgg ttggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat     1260

ggccccaaag tagacatctg gtctctgggt atcatggcta ttgaaatggt agaaggagag     1320

cctccatacc tcaatgaaaa tcctttgagg gccttgtacc tgatagcaac taatggaacc     1380

ccagaacttc agaatccaga gaagctttcc ccaatatttc gggatttctt aaatcgatgt     1440

ttggagatgg atgtggagaa aaggggttca gccagagaat tgttacagca tcccttcctg     1500

aaactggcca agccgttatc cagcttgaca ccactgatta tggcagctaa agaagcaatg     1560

aagagtaacc gttaa                                                      1575


<210>  58
<211>  524
<212>  PRT
<213>  Bos taurus

<400>  58

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Glu Ala Leu Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Gly Gly Ala Lys Thr Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Arg Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  59
<211>  1575
<212>  DNA
<213>  Mus musculus

<400>  59
atgtctgata acggagagct agaagacaag cccccagcac ctccagttcg gatgagcagt       60

accattttta gcaccggagg aaaagatcct ttatcagcca atcacagttt gaaacctttg      120

ccttctgttc cagaggaaaa aaaacccagg aacaaaatca tctccatatt ctctggcaca      180

gaaaaaggaa gtaaaaagaa agaaaaagaa cggccagaga tttctccccc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttacgggag agttcactgg catgccagaa      300

cagtgggcgc ggctgttgca gacctccaac attaccaaac tcgagcagaa gaagaaccct      360

caggcagtgc tggatgtctt gaagttctac gactccaaca ctgtgaaaca gaagtacctg      420

agtttcactc ctcctgagaa agatggcttc ccttctggaa caccagcact gaacaccaag      480

gggtcagaga catcagctgt agtgacagag gaagatgatg atgatgaaga cgctgctcct      540

cccgtcattg cccctcggcc agatcataca aaatcaattt acacacggtc tgtcatcgac      600

cccattcctg ctccagttgg tgattctaat gttgacagtg gtgccaagtc ttcagacaaa      660

cagaaaaaga aagccaagat gaccgatgaa gagattatgg agaaattaag aactattgtg      720

agcatagggg acccaaagaa aaaatacaca agatatgaaa aaattgggca aggggcttct      780

ggaacagttt ttactgccac tgatgtggcc ctggggcaag aggttgctat caagcagatt      840

aatttacaga aacaaccaaa gaaggaattg atcattaatg aaattctggt gatgaaagag      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tggtaggaga tgagttgttt      960

gtggtaatgg agtacctcgc tggtgggtcc ctcactgatg ttgtaacaga aacctgcatg     1020

gacgaagcgc agattgccgc cgtgtgcaga gagtgtttac aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg aatggaaggc     1140

tcagttaaac ttactgactt cggcttctgt gcccagatca ctcctgaaca gagcaaacgc     1200

agtactatgg ttggaacacc gtactggatg gcaccagagg tggtgacacg gaaagcctat     1260

ggtcccaaag ttgacatatg gtctctgggc atcatggcta tcgagatggt tgaaggagag     1320

cctccatacc tcaacgaaaa tcctctgcgg gcattatacc tgatagctac aaatggaact     1380

cctgaacttc agaatccaga aaaactttcc ccaatatttc gggatttctt aaatcggtgt     1440

ttggaaatgg atgtggagaa aaggggttcg gccaaggaac tgttacagca tcctttcctg     1500

aaactggcca aaccattgtc tagcttgacg ccactgatcc tggcagctaa agaagcaatg     1560

aagagtaacc gctaa                                                      1575


<210>  60
<211>  1629
<212>  DNA
<213>  Mus musculus

<400>  60
atgtctgata acggagagct agaagacaag cccccagcac ctccagttcg gatgagcagt       60

accattttta gcaccggagg aaaagatcct ttatcagcca atcacagttt gaaacctttg      120

ccttctgttc cagaggaaaa aaaacccagg aacaaaatca tctccatatt ctctggcaca      180

gaaaaaggaa gtaaaaagaa agaaaaagaa cggccagaga tttctccccc atctgatttt      240

gagcacacca tccatgttgg ctttgatgct gttacgggag agttcactgg catgccagaa      300

cagtgggcgc ggctgttgca gacctccaac attaccaaac tcgagcagaa gaagaaccct      360

caggcagtgc tggatgtctt gaagttctac gactccaaca ctgtgaaaca gaagtacctg      420

agtttcactc ctcctgagaa agatggcttc ccttctggaa caccagcact gaacaccaag      480

gggtcagaga catcagctgt agtgacagag gaagatgatg atgatgaaga cgctgctcct      540

cccgtcattg cccctcggcc agatcataca aaatcaattt acacacggtc tgtcatcgac      600

cccattcctg ctccagttgg tgattctaat gttgacagtg gtgccaagtc ttcagacaaa      660

cagaaaaaga aagccaagat gaccgatgaa gagattatgg agaaattaag aactattgtg      720

agcatagggg acccaaagaa aaaatacaca agatatgaaa aaattgggca aggggcttct      780

ggaacagttt ttactgccac tgatgtggcc ctggggcaag aggttgctat caagcagatt      840

aatttacaga aacaaccaaa gaaggaattg atcattaatg aaattctggt gatgaaagag      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tggtaggaga tgagttgttt      960

gtggtaatgg agtacctcgc tggtgggtcc ctcactgatg ttgtaacaga aacctgcatg     1020

gacgaagcgc agattgccgc cgtgtgcaga gagtgtttac aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg aatggaaggc     1140

tcagttaaac ttactgactt cggcttctgt gcccagatca ctcctgaaca gagcaaacgc     1200

agtactatgg ttggaacacc gtactggatg gcaccagagg tggtgacacg gaaagcctat     1260

ggtcccaaag ttgacatatg gtctctgggc atcatggcta tcgagatggt tgaaggagag     1320

cctccatacc tcaacgaaaa tcctctgcgg gcattatacc tgatagctac aaatggaact     1380

cctgaacttc agaatccaga aaaactttcc ccaatatttc gggatttctt aaatcggtgt     1440

ttggaaatgg atgtggagaa aaggggttcg gccaaggaac tgttacagca tcctttcctg     1500

aaactggcca aaccattgtc tagcttgacg ccactgatcc tggcagctaa agaagcaatg     1560

aagagtaacc gctaacatcg tcaccgaggc ctcctattcc cttatccatt ttttaaaaga     1620

agtctttta                                                             1629


<210>  61
<211>  524
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Asp Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Leu Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  62
<211>  524
<212>  PRT
<213>  Mus musculus

<400>  62

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Asp Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Leu Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  63
<211>  1575
<212>  DNA
<213>  Rattus norvegicus

<400>  63
atgtctgata acggggagct agaggacaag cccccagcac ctccagtgcg gatgagcagc       60

accattttta gcactggagg aaaggatcct ttatcagcca atcacagttt gaagcctttg      120

ccttctgttc cagaggaaaa aaaaccgagg aacaaaatca tctccatatt ctcaagcaca      180

gaaaaaggaa gtaaaaagaa agaaaaagaa cggccagaga tttctccgcc gtctgatttt      240

gagcatacca tccatgttgg ctttgatgct gttacgggag agttcactgg catgccagag      300

cagtgggcac ggctgttgca gacctccaac attaccaaac tggagcagaa gaagaacccg      360

caggctgtgc tggatgtctt gaagttctac gactccaaca ctgtgaagca gaagtacctg      420

agcttcactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaacaccaag      480

gggtcagaga catcagctgt ggtgacagag gaagacgatg acgatgaaga tgctgctcct      540

cccgtcattg cccctcggcc agatcataca aaatcaatct acacaaggtc tgtcatcgac      600

cctattcctg ctccagttgg tgactctaat gtcgacagtg gtgccaagtc ttcagacaaa      660

cagaaaaaga aagccaagat gaccgatgaa gagattatgg agaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatacaca agatatgaaa aaatcgggca aggggcttct      780

ggtacagttt ttactgcaac tgatgtggcc ctggggcaag aggttgctat caagcagatt      840

aatttacaga aacaaccaaa gaaggaattg atcattaatg aaattctggt gatgaaagag      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tggtaggaga cgagttgttt      960

gtggtaatgg agtaccttgc tggtgggtcc ctcactgatg tcgtgacaga aacctgcatg     1020

gatgaagcgc agatcgcagc tgtgtgcaga gagtgtttac aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg aatggaaggc     1140

tcagttaaac tcactgattt tggcttctgt gcccagatca cccctgaaca gagcaaacgc     1200

agtactatgg ttggaacacc atactggatg gcaccggagg tagtcacgcg gaaagcctat     1260

ggccccaaag ttgacatatg gtctctgggc atcatggcta tcgaaatggt ggaaggagag     1320

cctccatacc tcaatgaaaa tcctttacgg gcattatacc tgatagcaac gaatggaaca     1380

cctgagctcc agaatccaga aaaactttcc cccatatttc gggatttctt aaatcggtgt     1440

ttggaaatgg atgtggagaa gaggggttca gccaaagaac tattacagca tcctttcctg     1500

aaactggcca aaccattatc cagcttgacg cctctgatcc tggcagctaa agaagcaatg     1560

aagagtaacc gctaa                                                      1575


<210>  64
<211>  1575
<212>  DNA
<213>  Rattus norvegicus

<400>  64
atgtctgata acggggagct agaggacaag cccccagcac ctccagtgcg gatgagcagc       60

accattttta gcactggagg aaaggatcct ttatcagcca atcacagttt gaagcctttg      120

ccttctgttc cagaggaaaa aaaaccgagg aacaaaatca tctccatatt ctcaagcaca      180

gaaaaaggaa gtaaaaagaa agaaaaagaa cggccagaga tttctccgcc gtctgatttt      240

gagcatacca tccatgttgg ctttgatgct gttacgggag agttcactgg catgccagag      300

cagtgggcac ggctgttgca gacctccaac attaccaaac tggagcagaa gaagaacccg      360

caggctgtgc tggatgtctt gaagttctac gactccaaca ctgtgaagca gaagtacctg      420

agcttcactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaacaccaag      480

gggtcagaga catcagctgt ggtgacagag gaagacgatg acgatgaaga tgctgctcct      540

cccgtcattg cccctcggcc agatcataca aaatcaatct acacaaggtc tgtcatcgac      600

cctattcctg ctccagttgg tgactctaat gtcgacagtg gtgccaagtc ttcagacaaa      660

cagaaaaaga aagccaagat gaccgatgaa gagattatgg agaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatacaca agatatgaaa aaatcgggca aggggcttct      780

ggtacagttt ttactgcaac tgatgtggcc ctggggcaag aggttgctat caagcagatt      840

aatttacaga aacaaccaaa gaaggaattg atcattaatg aaattctggt gatgaaagag      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tggtaggaga cgagttgttt      960

gtggtaatgg agtaccttgc tggtgggtcc ctcactgatg tcgtgacaga aacctgcatg     1020

gatgaagcgc agatcgcagc tgtgtgcaga gagtgtttac aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg aatggaaggc     1140

tcagttaaac tcactgattt tggcttctgt gcccagatca cccctgaaca gagcaaacgc     1200

agtactatgg ttggaacacc atactggatg gcaccggagg tagtcacgcg gaaagcctat     1260

ggccccaaag ttgacatatg gtctctgggc atcatggcta tcgaaatggt ggaaggagag     1320

cctccatacc tcaatgaaaa tcctttacgg gcattatacc tgatagcaac gaatggaaca     1380

cctgagctcc agaatccaga aaaactttcc cccatatttc gggatttctt aaatcggtgt     1440

ttggaaatgg atgtggagaa gaggggttca gccaaagaac tattacagca tcctttcctg     1500

aaactggcca aaccattatc cagcttgacg cctctgatcc tggcagctaa agaagcaatg     1560

aagagtaacc gctaa                                                      1575


<210>  65
<211>  1575
<212>  DNA
<213>  Rattus norvegicus

<400>  65
atgtctgata acggggagct agaggacaag cccccagcac ctccagtgcg gatgagcagc       60

accattttta gcactggagg aaaggatcct ttatcagcca atcacagttt gaagcctttg      120

ccttctgttc cagaggaaaa aaaaccgagg aacaaaatca tctccatatt ctcaagcaca      180

gaaaaaggaa gtaaaaagaa agaaaaagaa cggccagaga tttctccgcc gtctgatttt      240

gagcatacca tccatgttgg ctttgatgct gttacgggag agttcactgg catgccagag      300

cagtgggcac ggctgttgca gacctccaac attaccaaac tggagcagaa gaagaacccg      360

caggctgtgc tggatgtctt gaagttctac gactccaaca ctgtgaagca gaagtacctg      420

agcttcactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaacaccaag      480

gggtcagaga catcagctgt ggtgacagag gaagacgatg acgatgaaga tgctgctcct      540

cccgtcattg cccctcggcc agatcataca aaatcaatct acacaaggtc tgtcatcgac      600

cctattcctg ctccagttgg tgactctaat gtcgacagtg gtgccaagtc ttcagacaaa      660

cagaaaaaga aagccaagat gaccgatgaa gagattatgg agaaattaag aactattgtg      720

agcataggtg accctaagaa aaaatacaca agatatgaaa aaatcgggca aggggcttct      780

ggtacagttt ttactgcaac tgatgtggcc ctggggcaag aggttgctat caagcagatt      840

aatttacaga aacaaccaaa gaaggaattg atcattaatg aaattctggt gatgaaagag      900

ttaaagaatc ccaacatagt taacttcttg gacagttacc tggtaggaga cgagttgttt      960

gtggtaatgg agtaccttgc tggtgggtcc ctcactgatg tcgtgacaga aacctgcatg     1020

gatgaagcgc agatcgcagc tgtgtgcaga gagtgtttac aggcgttgga gtttttacat     1080

gctaatcaag tgatccacag agacatcaaa agtgacaatg tgcttttggg aatggaaggc     1140

tcagttaaac tcactgattt tggcttctgt gcccagatca cccctgaaca gagcaaacgc     1200

agtactatgg ttggaacacc atactggatg gcaccggagg tagtcacgcg gaaagcctat     1260

ggccccaaag ttgacatatg gtctctgggc atcatggcta tcgaaatggt ggaaggagag     1320

cctccatacc tcaatgaaaa tcctttacgg gcattatacc tgatagcaac gaatggaaca     1380

cctgagctcc agaatccaga aaaactttcc cccatatttc gggatttctt aaatcggtgt     1440

ttggaaatgg atgtggagaa gaggggttca gccaaagaac tattacagca tcctttcctg     1500

aaactggcca aaccattatc cagcttgacg cctctgatcc tggcagctaa agaagcaatg     1560

aagagtaacc gctaa                                                      1575


<210>  66
<211>  524
<212>  PRT
<213>  Rattus norvegicus

<400>  66

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Asp Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Leu Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  67
<211>  524
<212>  PRT
<213>  Rattus norvegicus

<400>  67

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Asp Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Leu Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  68
<211>  524
<212>  PRT
<213>  Rattus norvegicus

<400>  68

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser 
            20                  25                  30          


Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys 
        35                  40                  45              


Pro Arg Asn Lys Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser 
    50                  55                  60                  


Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe 
65                  70                  75                  80  


Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr 
                85                  90                  95      


Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr 
            100                 105                 110         


Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys 
        115                 120                 125             


Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro 
    130                 135                 140                 


Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Thr Lys 
145                 150                 155                 160 


Gly Ser Glu Thr Ser Ala Val Val Thr Glu Glu Asp Asp Asp Asp Glu 
                165                 170                 175     


Asp Ala Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser 
            180                 185                 190         


Ile Tyr Thr Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Val Gly Asp 
        195                 200                 205             


Ser Asn Val Asp Ser Gly Ala Lys Ser Ser Asp Lys Gln Lys Lys Lys 
    210                 215                 220                 


Ala Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val 
225                 230                 235                 240 


Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly 
                245                 250                 255     


Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly 
            260                 265                 270         


Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys 
        275                 280                 285             


Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro 
    290                 295                 300                 


Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe 
305                 310                 315                 320 


Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr 
                325                 330                 335     


Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys 
            340                 345                 350         


Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp 
        355                 360                 365             


Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu 
    370                 375                 380                 


Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg 
385                 390                 395                 400 


Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr 
                405                 410                 415     


Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met 
            420                 425                 430         


Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro 
        435                 440                 445             


Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln 
    450                 455                 460                 


Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys 
465                 470                 475                 480 


Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln 
                485                 490                 495     


His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu 
            500                 505                 510         


Ile Leu Ala Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520                 


<210>  69
<211>  1566
<212>  DNA
<213>  Gallus gallus

<400>  69
atgtctgaca acggagaact ggaagacaag ccaccagctc ctcctgtgcg gatgagcagt       60

tatgggggaa aggacccgtt gtctgccaac cacagcttga aacctctgcc ctccgtacca      120

gaagagagaa aacctaggaa taaaatcatc tccatattct ctagcactga aaaaggaagc      180

aagaagaagg aaaaggaacg accagaaatc tccccgccgt cagactttga gcatactatc      240

catgttggct ttgatgctgt cactggagag ttcactggaa tgccagagca atgggctcgg      300

ttgctacaga cctcaaacat caccaagtta gaacagaaga aaaaccctca ggcggtacta      360

gatgtgctga aattctacga ctccaaagac acagcaaaac agaaatatct gagcttttct      420

gctccagaaa aagatggctt cccttcagga acaccaacga ccaatgccaa aggttcagag      480

ccatcaacag ctgtggcaga tgacgatgac gatgatgaag aagcacctcc tcctattatt      540

gctccgcggc cagatcacac gaaatcgatt tatacacggt ctgtaattga ccccatccct      600

gcaccagctg gtgacgcttc tgttgatggt gggacaaagt caggtgataa gcagaaaaag      660

aagaccaaaa tgtcagatga agagatcatg gaaaaactac gtaccattgt gagcataggt      720

gatcccaaga aaaaatacac cagatatgaa aaaattgggc agggggcttc aggtacagtt      780

ttcacagcta ttgacgtggc tactgggcag gaggttgcta tcaaacagat aaacctgcag      840

aaacagccca agaaggagtt gattattaat gagatcttgg taatgaagga actaaagaac      900

cccaacatag tcaacttcct ggacagttac ctcgtaggag atgaactgtt tgtggtgatg      960

gagtatctag ctggaggctc actaacagat gtggttacgg aaacatgtat ggatgaagca     1020

cagattgctg ctgtttgcag ggagtgcttg caagcgcttg agttcctcca tgccaaccag     1080

gtcatccaca gagatataaa gagcgacaac gtgctgctag gaatggatgg atcagttaaa     1140

ctaaccgact ttggtttctg tgctcagatc accccagagc agagcaagcg cagcactatg     1200

gttggaacac cttactggat ggctcctgaa gtcgtcacac ggaaagccta tggccctaaa     1260

gtggatatct ggtccctagg catcatggct attgagatgg tggaaggaga acccccgtac     1320

ctcaatgaaa accccctgag ggcgttatat ttgatagcaa ctaacggcac accagagctt     1380

cagaaccctg agaaactgtc cccaatattc cgggatttct taaaccgatg tttggagatg     1440

gatgttgaga aaagaggatc agccaaagaa ttgctacagc atcccttctt gaaattggcc     1500

aaacctctgt ctagcttgac gccactgatc ctggcagcca aagaagcaat gaagagtaac     1560

cgctaa                                                                1566


<210>  70
<211>  1566
<212>  DNA
<213>  Gallus gallus

<400>  70
atgtctgaca acggagaact ggaagacaag ccaccagctc ctcctgtgcg gatgagcagt       60

tatgggggaa aggacccgtt gtctgccaac cacagcttga aacctctgcc ctccgtacca      120

gaagagagaa aacctaggaa taaaatcatc tccatattct ctagcactga aaaaggaagc      180

aagaagaagg aaaaggaacg accagaaatc tccccgccgt cagactttga gcatactatc      240

catgttggct ttgatgctgt cactggagag ttcactggaa tgccagagca atgggctcgg      300

ttgctacaga cctcaaacat caccaagtta gaacagaaga aaaaccctca ggcggtacta      360

gatgtgctga aattctacga ctccaaagac acagcaaaac agaaatatct gagcttttct      420

gctccagaaa aagatggctt cccttcagga acaccaacga ccaatgccaa aggttcagag      480

ccatcaacag ctgtggcaga tgacgatgac gatgatgaag aagcacctcc tcctattatt      540

gctccgcggc cagatcacac gaaatcgatt tatacacggt ctgtaattga ccccatccct      600

gcaccagctg gtgacgcttc tgttgatggt gggacaaagt caggtgataa gcagaaaaag      660

aagaccaaaa tgtcagatga agagatcatg gaaaaactac gtaccattgt gagcataggt      720

gatcccaaga aaaaatacac cagatatgaa aaaattgggc agggggcttc aggtacagtt      780

ttcacagcta ttgacgtggc tactgggcag gaggttgcta tcaaacagat aaacctgcag      840

aaacagccca agaaggagtt gattattaat gagatcttgg taatgaagga actaaagaac      900

cccaacatag tcaacttcct ggacagttac ctcgtaggag atgaactgtt tgtggtgatg      960

gagtatctag ctggaggctc actaacagat gtggttacgg aaacatgtat ggatgaagca     1020

cagattgctg ctgtttgcag ggagtgcttg caagcgcttg agttcctcca tgccaaccag     1080

gtcatccaca gagatataaa gagcgacaac gtgctgctag gaatggatgg atcagttaaa     1140

ctaaccgact ttggtttctg tgctcagatc accccagagc agagcaagcg cagcactatg     1200

gttggaacac cttactggat ggctcctgaa gtcgtcacac ggaaagccta tggccctaaa     1260

gtggatatct ggtccctagg catcatggct attgagatgg tggaaggaga acccccgtac     1320

ctcaatgaaa accccctgag ggcgttatat ttgatagcaa ctaacggcac accagagctt     1380

cagaaccctg agaaactgtc cccaatattc cgggatttct taaaccgatg tttggagatg     1440

gatgttgaga aaagaggatc agccaaagaa ttgctacagc atcccttctt gaaattggcc     1500

aaacctctgt ctagcttgac gccactgatc ctggcagcca aagaagcaat gaagagtaac     1560

cgctaa                                                                1566


<210>  71
<211>  521
<212>  PRT
<213>  Gallus gallus

<400>  71

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Tyr Gly Gly Lys Asp Pro Leu Ser Ala Asn His Ser 
            20                  25                  30          


Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Arg Lys Pro Arg Asn Lys 
        35                  40                  45              


Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser Lys Lys Lys Glu 
    50                  55                  60                  


Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe Glu His Thr Ile 
65                  70                  75                  80  


His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro Glu 
                85                  90                  95      


Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln 
            100                 105                 110         


Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser 
        115                 120                 125             


Lys Asp Thr Ala Lys Gln Lys Tyr Leu Ser Phe Ser Ala Pro Glu Lys 
    130                 135                 140                 


Asp Gly Phe Pro Ser Gly Thr Pro Thr Thr Asn Ala Lys Gly Ser Glu 
145                 150                 155                 160 


Pro Ser Thr Ala Val Ala Asp Asp Asp Asp Asp Asp Glu Glu Ala Pro 
                165                 170                 175     


Pro Pro Ile Ile Ala Pro Arg Pro Asp His Thr Lys Ser Ile Tyr Thr 
            180                 185                 190         


Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Ala Gly Asp Ala Ser Val 
        195                 200                 205             


Asp Gly Gly Thr Lys Ser Gly Asp Lys Gln Lys Lys Lys Thr Lys Met 
    210                 215                 220                 


Ser Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val Ser Ile Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly Gln Gly Ala 
                245                 250                 255     


Ser Gly Thr Val Phe Thr Ala Ile Asp Val Ala Thr Gly Gln Glu Val 
            260                 265                 270         


Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys Glu Leu Ile 
        275                 280                 285             


Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro Asn Ile Val 
    290                 295                 300                 


Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe Val Val Met 
305                 310                 315                 320 


Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr Glu Thr Cys 
                325                 330                 335     


Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys Leu Gln Ala 
            340                 345                 350         


Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp Ile Lys Ser 
        355                 360                 365             


Asp Asn Val Leu Leu Gly Met Asp Gly Ser Val Lys Leu Thr Asp Phe 
    370                 375                 380                 


Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg Ser Thr Met 
385                 390                 395                 400 


Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr Arg Lys Ala 
                405                 410                 415     


Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met Ala Ile Glu 
            420                 425                 430         


Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro Leu Arg Ala 
        435                 440                 445             


Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln Asn Pro Glu 
    450                 455                 460                 


Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys Leu Glu Met 
465                 470                 475                 480 


Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln His Pro Phe 
                485                 490                 495     


Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu Ile Leu Ala 
            500                 505                 510         


Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520     


<210>  72
<211>  521
<212>  PRT
<213>  Gallus gallus

<400>  72

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Arg Met Ser Ser Tyr Gly Gly Lys Asp Pro Leu Ser Ala Asn His Ser 
            20                  25                  30          


Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Arg Lys Pro Arg Asn Lys 
        35                  40                  45              


Ile Ile Ser Ile Phe Ser Ser Thr Glu Lys Gly Ser Lys Lys Lys Glu 
    50                  55                  60                  


Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe Glu His Thr Ile 
65                  70                  75                  80  


His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro Glu 
                85                  90                  95      


Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln 
            100                 105                 110         


Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser 
        115                 120                 125             


Lys Asp Thr Ala Lys Gln Lys Tyr Leu Ser Phe Ser Ala Pro Glu Lys 
    130                 135                 140                 


Asp Gly Phe Pro Ser Gly Thr Pro Thr Thr Asn Ala Lys Gly Ser Glu 
145                 150                 155                 160 


Pro Ser Thr Ala Val Ala Asp Asp Asp Asp Asp Asp Glu Glu Ala Pro 
                165                 170                 175     


Pro Pro Ile Ile Ala Pro Arg Pro Asp His Thr Lys Ser Ile Tyr Thr 
            180                 185                 190         


Arg Ser Val Ile Asp Pro Ile Pro Ala Pro Ala Gly Asp Ala Ser Val 
        195                 200                 205             


Asp Gly Gly Thr Lys Ser Gly Asp Lys Gln Lys Lys Lys Thr Lys Met 
    210                 215                 220                 


Ser Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val Ser Ile Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly Gln Gly Ala 
                245                 250                 255     


Ser Gly Thr Val Phe Thr Ala Ile Asp Val Ala Thr Gly Gln Glu Val 
            260                 265                 270         


Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys Glu Leu Ile 
        275                 280                 285             


Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro Asn Ile Val 
    290                 295                 300                 


Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe Val Val Met 
305                 310                 315                 320 


Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr Glu Thr Cys 
                325                 330                 335     


Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys Leu Gln Ala 
            340                 345                 350         


Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp Ile Lys Ser 
        355                 360                 365             


Asp Asn Val Leu Leu Gly Met Asp Gly Ser Val Lys Leu Thr Asp Phe 
    370                 375                 380                 


Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg Ser Thr Met 
385                 390                 395                 400 


Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr Arg Lys Ala 
                405                 410                 415     


Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met Ala Ile Glu 
            420                 425                 430         


Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro Leu Arg Ala 
        435                 440                 445             


Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln Asn Pro Glu 
    450                 455                 460                 


Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys Leu Glu Met 
465                 470                 475                 480 


Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln His Pro Phe 
                485                 490                 495     


Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu Ile Leu Ala 
            500                 505                 510         


Ala Lys Glu Ala Met Lys Ser Asn Arg 
        515                 520     


<210>  73
<211>  1557
<212>  DNA
<213>  Xenopus tropicalis

<400>  73
atgtctgata acggggagct tgaagataag ccgccagctc ctccagctcg gattagcagc       60

acagggacaa aagatcctct gaccagcaac cacagtcata aacctttacc tttaatccct      120

gaaaaaccca ggaataaaat tatttcaatg ttttctggca cagaaaaagg aagcagaaaa      180

aaagaaaggg aaaggccaga gatttcacca ccgtcagatt ttgagcacac tattcatgtg      240

ggctttgatg ctgtcactgg agaattcact ggaatgccag agcaatgggc acggttactg      300

cagacctcaa acattactaa actcgaacag aagaaaaatc cacaagctgt cctggatgtt      360

ttaaagtttt atgactccaa acacacagac aagcagaaat atctaagctt ctctgcacca      420

gataaagatg ggcttccctc tggtgtttcc tctgcaccta atgcaaaagg ctctgaacct      480

tcaacagcag caacagatga tgatagcgat gatgataagg ctcctcctcc tgttattgct      540

ccaaggccag aacacaccaa atcaatgtat acacggtctg taattgaccc aatacctcca      600

ccccctggag attcagacag tgctgcaaag gctggagacc ggcagaaaaa gaaaacaaag      660

atgagcgatg aagagattat ggaaaaactt agaactatag taagcatagg agaccccaag      720

aaaaaatata ctagatatga aaaaattgga caaggggcct ctggaactgt atttactgct      780

attgatgtag ctaccggaca ggaggttgca atcaaacaga taaatcttca gaagcagccc      840

aagaaagaac tgataatcaa tgagattcta gtgatgaaag aattgaagaa ccccaatata      900

gtaaatttcc tggacagttt cttggtgagt gacgagctgt atgttgtaat ggagtatttg      960

gctggaggat cccttacaga cgtagtcaca gaaacctgta tggatgaggc acagatagca     1020

gctgtctgca gagagtgtct gcaagctttg gaattcctac atgcgaacca ggtcattcac     1080

agagacataa agagtgacaa tgttctcctt ggaatggatg gttctgtcaa actgaccgac     1140

tttggcttct gtgcacaaat taccccagaa cagagcaagc gaagcaccat ggtgggaaca     1200

ccatactgga tggcaccaga agtggttaca aggaaagcat atggccccaa ggtggatatc     1260

tggtcacttg gaattatggc tattgaaatg gtggaagggg aaccacctta tctcaacgaa     1320

aatcctttaa gggctttgta tttgattgct actaatggaa ctccggaact tcagaaacct     1380

gaaaaacttt caccgatatt ccgggatttc ttaaaccgct cacttgagat ggatgtagaa     1440

aagagagggt ccgctagaga gctcttacag cacccattcc tgaaactcgc aaaaccactg     1500

tccagcctca caccgctaat cctggctgcc aaagaagcga tgaagggaaa ccgctaa        1557


<210>  74
<211>  1557
<212>  DNA
<213>  Xenopus tropicalis

<400>  74
atgtctgata acggggagct tgaagataag ccgccagctc ctccagctcg gattagcagc       60

acagggacaa aagatcctct gaccagcaac cacagtcata aacctttacc tttaatccct      120

gaaaaaccca ggaataaaat tatttcaatg ttttctggca cagaaaaagg aagcagaaaa      180

aaagaaaggg aaaggccaga gatttcacca ccgtcagatt ttgagcacac tattcatgtg      240

ggctttgatg ctgtcactgg agaattcact ggaatgccag agcaatgggc acggttactg      300

cagacctcaa acattactaa actcgaacag aagaaaaatc cacaagctgt cctggatgtt      360

ttaaagtttt atgactccaa acacacagac aagcagaaat atctaagctt ctctgcacca      420

gataaagatg ggcttccctc tggtgtttcc tctgcaccta atgcaaaagg ctctgaacct      480

tcaacagcag caacagatga tgatagcgat gatgataagg ctcctcctcc tgttattgct      540

ccaaggccag aacacaccaa atcaatgtat acacggtctg taattgaccc aatacctcca      600

ccccctggag attcagacag tgctgcaaag gctggagacc ggcagaaaaa gaaaacaaag      660

atgagcgatg aagagattat ggaaaaactt agaactatag taagcatagg agaccccaag      720

aaaaaatata ctagatatga aaaaattgga caaggggcct ctggaactgt atttactgct      780

attgatgtag ctaccggaca ggaggttgca atcaaacaga taaatcttca gaagcagccc      840

aagaaagaac tgataatcaa tgagattcta gtgatgaaag aattgaagaa ccccaatata      900

gtaaatttcc tggacagttt cttggtgagt gacgagctgt atgttgtaat ggagtatttg      960

gctggaggat cccttacaga cgtagtcaca gaaacctgta tggatgaggc acagatagca     1020

gctgtctgca gagagtgtct gcaagctttg gaattcctac atgcgaacca ggtcattcac     1080

agagacataa agagtgacaa tgttctcctt ggaatggatg gttctgtcaa actgaccgac     1140

tttggcttct gtgcacaaat taccccagaa cagagcaagc gaagcaccat ggtgggaaca     1200

ccatactgga tggcaccaga agtggttaca aggaaagcat atggccccaa ggtggatatc     1260

tggtcacttg gaattatggc tattgaaatg gtggaagggg aaccacctta tctcaacgaa     1320

aatcctttaa gggctttgta tttgattgct actaatggaa ctccggaact tcagaaacct     1380

gaaaaacttt caccgatatt ccgggatttc ttaaaccgct cacttgagat ggatgtagaa     1440

aagagagggt ccgctagaga gctcttacag cacccattcc tgaaactcgc aaaaccactg     1500

tccagcctca caccgctaat cctggctgcc aaagaagcga tgaagggaaa ccgctaa        1557


<210>  75
<211>  1557
<212>  DNA
<213>  Xenopus tropicalis

<400>  75
atgtctgata acggggagct tgaagataag ccgccagctc ctccagctcg gattagcagc       60

acagggacaa aagatcctct gaccagcaac cacagtcata aacctttacc tttaatccct      120

gaaaaaccca ggaataaaat tatttcaatg ttttctggca cagaaaaagg aagcagaaaa      180

aaagaaaggg aaaggccaga gatttcacca ccgtcagatt ttgagcacac tattcatgtg      240

ggctttgatg ctgtcactgg agaattcact ggaatgccag agcaatgggc acggttactg      300

cagacctcaa acattactaa actcgaacag aagaaaaatc cacaagctgt cctggatgtt      360

ttaaagtttt atgactccaa acacacagac aagcagaaat atctaagctt ctctgcacca      420

gataaagatg ggcttccctc tggtgtttcc tctgcaccta atgcaaaagg ctctgaacct      480

tcaacagcag caacagatga tgatagcgat gatgataagg ctcctcctcc tgttattgct      540

ccaaggccag aacacaccaa atcaatgtat acacggtctg taattgaccc aatacctcca      600

ccccctggag attcagacag tgctgcaaag gctggagacc ggcagaaaaa gaaaacaaag      660

atgagcgatg aagagattat ggaaaaactt agaactatag taagcatagg agaccccaag      720

aaaaaatata ctagatatga aaaaattgga caaggggcct ctggaactgt atttactgct      780

attgatgtag ctaccggaca ggaggttgca atcaaacaga taaatcttca gaagcagccc      840

aagaaagaac tgataatcaa tgagattcta gtgatgaaag aattgaagaa ccccaatata      900

gtaaatttcc tggacagttt cttggtgagt gacgagctgt atgttgtaat ggagtatttg      960

gctggaggat cccttacaga cgtagtcaca gaaacctgta tggatgaggc acagatagca     1020

gctgtctgca gagagtgtct gcaagctttg gaattcctac atgcgaacca ggtcattcac     1080

agagacataa agagtgacaa tgttctcctt ggaatggatg gttctgtcaa actgaccgac     1140

tttggcttct gtgcacaaat taccccagaa cagagcaagc gaagcaccat ggtgggaaca     1200

ccatactgga tggcaccaga agtggttaca aggaaagcat atggccccaa ggtggatatc     1260

tggtcacttg gaattatggc tattgaaatg gtggaagggg aaccacctta tctcaacgaa     1320

aatcctttaa gggctttgta tttgattgct actaatggaa ctccggaact tcagaaacct     1380

gaaaaacttt caccgatatt ccgggatttc ttaaaccgct cacttgagat ggatgtagaa     1440

aagagagggt ccgctagaga gctcttacag cacccattcc tgaaactcgc aaaaccactg     1500

tccagcctca caccgctaat cctggctgcc aaagaagcga tgaagggaaa ccgctaa        1557


<210>  76
<211>  518
<212>  PRT
<213>  Xenopus tropicalis

<400>  76

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Ala 
1               5                   10                  15      


Arg Ile Ser Ser Thr Gly Thr Lys Asp Pro Leu Thr Ser Asn His Ser 
            20                  25                  30          


His Lys Pro Leu Pro Leu Ile Pro Glu Lys Pro Arg Asn Lys Ile Ile 
        35                  40                  45              


Ser Met Phe Ser Gly Thr Glu Lys Gly Ser Arg Lys Lys Glu Arg Glu 
    50                  55                  60                  


Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe Glu His Thr Ile His Val 
65                  70                  75                  80  


Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro Glu Gln Trp 
                85                  90                  95      


Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln Lys Lys 
            100                 105                 110         


Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser Lys His 
        115                 120                 125             


Thr Asp Lys Gln Lys Tyr Leu Ser Phe Ser Ala Pro Asp Lys Asp Gly 
    130                 135                 140                 


Leu Pro Ser Gly Val Ser Ser Ala Pro Asn Ala Lys Gly Ser Glu Pro 
145                 150                 155                 160 


Ser Thr Ala Ala Thr Asp Asp Asp Ser Asp Asp Asp Lys Ala Pro Pro 
                165                 170                 175     


Pro Val Ile Ala Pro Arg Pro Glu His Thr Lys Ser Met Tyr Thr Arg 
            180                 185                 190         


Ser Val Ile Asp Pro Ile Pro Pro Pro Pro Gly Asp Ser Asp Ser Ala 
        195                 200                 205             


Ala Lys Ala Gly Asp Arg Gln Lys Lys Lys Thr Lys Met Ser Asp Glu 
    210                 215                 220                 


Glu Ile Met Glu Lys Leu Arg Thr Ile Val Ser Ile Gly Asp Pro Lys 
225                 230                 235                 240 


Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr 
                245                 250                 255     


Val Phe Thr Ala Ile Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys 
            260                 265                 270         


Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu 
        275                 280                 285             


Ile Leu Val Met Lys Glu Leu Lys Asn Pro Asn Ile Val Asn Phe Leu 
    290                 295                 300                 


Asp Ser Phe Leu Val Ser Asp Glu Leu Tyr Val Val Met Glu Tyr Leu 
305                 310                 315                 320 


Ala Gly Gly Ser Leu Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu 
                325                 330                 335     


Ala Gln Ile Ala Ala Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe 
            340                 345                 350         


Leu His Ala Asn Gln Val Ile His Arg Asp Ile Lys Ser Asp Asn Val 
        355                 360                 365             


Leu Leu Gly Met Asp Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys 
    370                 375                 380                 


Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr 
385                 390                 395                 400 


Pro Tyr Trp Met Ala Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro 
                405                 410                 415     


Lys Val Asp Ile Trp Ser Leu Gly Ile Met Ala Ile Glu Met Val Glu 
            420                 425                 430         


Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu 
        435                 440                 445             


Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln Lys Pro Glu Lys Leu Ser 
    450                 455                 460                 


Pro Ile Phe Arg Asp Phe Leu Asn Arg Ser Leu Glu Met Asp Val Glu 
465                 470                 475                 480 


Lys Arg Gly Ser Ala Arg Glu Leu Leu Gln His Pro Phe Leu Lys Leu 
                485                 490                 495     


Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu Ile Leu Ala Ala Lys Glu 
            500                 505                 510         


Ala Met Lys Gly Asn Arg 
        515             


<210>  77
<211>  518
<212>  PRT
<213>  Xenopus tropicalis

<400>  77

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Ala 
1               5                   10                  15      


Arg Ile Ser Ser Thr Gly Thr Lys Asp Pro Leu Thr Ser Asn His Ser 
            20                  25                  30          


His Lys Pro Leu Pro Leu Ile Pro Glu Lys Pro Arg Asn Lys Ile Ile 
        35                  40                  45              


Ser Met Phe Ser Gly Thr Glu Lys Gly Ser Arg Lys Lys Glu Arg Glu 
    50                  55                  60                  


Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe Glu His Thr Ile His Val 
65                  70                  75                  80  


Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro Glu Gln Trp 
                85                  90                  95      


Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln Lys Lys 
            100                 105                 110         


Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser Lys His 
        115                 120                 125             


Thr Asp Lys Gln Lys Tyr Leu Ser Phe Ser Ala Pro Asp Lys Asp Gly 
    130                 135                 140                 


Leu Pro Ser Gly Val Ser Ser Ala Pro Asn Ala Lys Gly Ser Glu Pro 
145                 150                 155                 160 


Ser Thr Ala Ala Thr Asp Asp Asp Ser Asp Asp Asp Lys Ala Pro Pro 
                165                 170                 175     


Pro Val Ile Ala Pro Arg Pro Glu His Thr Lys Ser Met Tyr Thr Arg 
            180                 185                 190         


Ser Val Ile Asp Pro Ile Pro Pro Pro Pro Gly Asp Ser Asp Ser Ala 
        195                 200                 205             


Ala Lys Ala Gly Asp Arg Gln Lys Lys Lys Thr Lys Met Ser Asp Glu 
    210                 215                 220                 


Glu Ile Met Glu Lys Leu Arg Thr Ile Val Ser Ile Gly Asp Pro Lys 
225                 230                 235                 240 


Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr 
                245                 250                 255     


Val Phe Thr Ala Ile Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys 
            260                 265                 270         


Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu 
        275                 280                 285             


Ile Leu Val Met Lys Glu Leu Lys Asn Pro Asn Ile Val Asn Phe Leu 
    290                 295                 300                 


Asp Ser Phe Leu Val Ser Asp Glu Leu Tyr Val Val Met Glu Tyr Leu 
305                 310                 315                 320 


Ala Gly Gly Ser Leu Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu 
                325                 330                 335     


Ala Gln Ile Ala Ala Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe 
            340                 345                 350         


Leu His Ala Asn Gln Val Ile His Arg Asp Ile Lys Ser Asp Asn Val 
        355                 360                 365             


Leu Leu Gly Met Asp Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys 
    370                 375                 380                 


Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr 
385                 390                 395                 400 


Pro Tyr Trp Met Ala Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro 
                405                 410                 415     


Lys Val Asp Ile Trp Ser Leu Gly Ile Met Ala Ile Glu Met Val Glu 
            420                 425                 430         


Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu 
        435                 440                 445             


Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln Lys Pro Glu Lys Leu Ser 
    450                 455                 460                 


Pro Ile Phe Arg Asp Phe Leu Asn Arg Ser Leu Glu Met Asp Val Glu 
465                 470                 475                 480 


Lys Arg Gly Ser Ala Arg Glu Leu Leu Gln His Pro Phe Leu Lys Leu 
                485                 490                 495     


Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu Ile Leu Ala Ala Lys Glu 
            500                 505                 510         


Ala Met Lys Gly Asn Arg 
        515             


<210>  78
<211>  518
<212>  PRT
<213>  Xenopus tropicalis

<400>  78

Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Ala 
1               5                   10                  15      


Arg Ile Ser Ser Thr Gly Thr Lys Asp Pro Leu Thr Ser Asn His Ser 
            20                  25                  30          


His Lys Pro Leu Pro Leu Ile Pro Glu Lys Pro Arg Asn Lys Ile Ile 
        35                  40                  45              


Ser Met Phe Ser Gly Thr Glu Lys Gly Ser Arg Lys Lys Glu Arg Glu 
    50                  55                  60                  


Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe Glu His Thr Ile His Val 
65                  70                  75                  80  


Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro Glu Gln Trp 
                85                  90                  95      


Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln Lys Lys 
            100                 105                 110         


Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser Lys His 
        115                 120                 125             


Thr Asp Lys Gln Lys Tyr Leu Ser Phe Ser Ala Pro Asp Lys Asp Gly 
    130                 135                 140                 


Leu Pro Ser Gly Val Ser Ser Ala Pro Asn Ala Lys Gly Ser Glu Pro 
145                 150                 155                 160 


Ser Thr Ala Ala Thr Asp Asp Asp Ser Asp Asp Asp Lys Ala Pro Pro 
                165                 170                 175     


Pro Val Ile Ala Pro Arg Pro Glu His Thr Lys Ser Met Tyr Thr Arg 
            180                 185                 190         


Ser Val Ile Asp Pro Ile Pro Pro Pro Pro Gly Asp Ser Asp Ser Ala 
        195                 200                 205             


Ala Lys Ala Gly Asp Arg Gln Lys Lys Lys Thr Lys Met Ser Asp Glu 
    210                 215                 220                 


Glu Ile Met Glu Lys Leu Arg Thr Ile Val Ser Ile Gly Asp Pro Lys 
225                 230                 235                 240 


Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr 
                245                 250                 255     


Val Phe Thr Ala Ile Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys 
            260                 265                 270         


Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu 
        275                 280                 285             


Ile Leu Val Met Lys Glu Leu Lys Asn Pro Asn Ile Val Asn Phe Leu 
    290                 295                 300                 


Asp Ser Phe Leu Val Ser Asp Glu Leu Tyr Val Val Met Glu Tyr Leu 
305                 310                 315                 320 


Ala Gly Gly Ser Leu Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu 
                325                 330                 335     


Ala Gln Ile Ala Ala Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe 
            340                 345                 350         


Leu His Ala Asn Gln Val Ile His Arg Asp Ile Lys Ser Asp Asn Val 
        355                 360                 365             


Leu Leu Gly Met Asp Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys 
    370                 375                 380                 


Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr 
385                 390                 395                 400 


Pro Tyr Trp Met Ala Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro 
                405                 410                 415     


Lys Val Asp Ile Trp Ser Leu Gly Ile Met Ala Ile Glu Met Val Glu 
            420                 425                 430         


Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu 
        435                 440                 445             


Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln Lys Pro Glu Lys Leu Ser 
    450                 455                 460                 


Pro Ile Phe Arg Asp Phe Leu Asn Arg Ser Leu Glu Met Asp Val Glu 
465                 470                 475                 480 


Lys Arg Gly Ser Ala Arg Glu Leu Leu Gln His Pro Phe Leu Lys Leu 
                485                 490                 495     


Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu Ile Leu Ala Ala Lys Glu 
            500                 505                 510         


Ala Met Lys Gly Asn Arg 
        515             


<210>  79
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  79
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggag gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  80
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  80
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggag gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catatatgcc      720

agggttatcc agaagcgagt ccccaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgat      900

gaggacttca gctga                                                       915


<210>  81
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  82
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  83
<211>  915
<212>  DNA
<213>  Pan troglodytes

<400>  83
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgctca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catatatgcc      720

agggttatcc agaagcgagt ccccaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgat      900

gaggacttca gctga                                                       915


<210>  84
<211>  615
<212>  DNA
<213>  Pan troglodytes

<400>  84
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgctca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  85
<211>  304
<212>  PRT
<213>  Pan troglodytes

<400>  85

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  86
<211>  204
<212>  PRT
<213>  Pan troglodytes

<400>  86

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  87
<211>  915
<212>  DNA
<213>  Macaca mulatta

<400>  87
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgcca gtgccgccgt cgcccgccca acctccgccg      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc ggtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catatatgcc      720

agggttatcc agaagcgagt ccccaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgat      900

gaggacttca gctga                                                       915


<210>  88
<211>  615
<212>  DNA
<213>  Macaca mulatta

<400>  88
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagtcgg       60

caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgcca gtgccgccgt cgcccgccca acctccgccg      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc ggtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga      480

atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  89
<211>  304
<212>  PRT
<213>  Macaca mulatta

<400>  89

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  90
<211>  204
<212>  PRT
<213>  Macaca mulatta

<400>  90

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  91
<211>  915
<212>  DNA
<213>  Canis familiaris

<400>  91
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagccgg       60

caggaggcgg tggcgctgtt gcagggccag cggcacgggg tgtttctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcggaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgtct gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ttatttggac actacaacat tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgagata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg caagaggggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catttatgcc      720

agggtaatcc agaagcgagt ccctaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggaatgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcctgat      900

gaggacttca gctga                                                       915


<210>  92
<211>  615
<212>  DNA
<213>  Canis familiaris

<400>  92
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagccgg       60

caggaggcgg tggcgctgtt gcagggccag cggcacgggg tgtttctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctcggaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgtct gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ttatttggac actacaacat tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgagccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgagata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg caagaggggg      540

atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  93
<211>  304
<212>  PRT
<213>  Canis familiaris

<400>  93

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Ser Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  94
<211>  204
<212>  PRT
<213>  Canis familiaris

<400>  94

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Ser Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  95
<211>  915
<212>  DNA
<213>  Bos taurus

<400>  95
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gctgagtcgg       60

caggaggcgg tggcgctgtt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcactagcc ccggggacta tgtgctcagc gtctccgaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagtc cctccagact ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaagagg cagagtatgt acgagccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catttatgcc      720

agggtaatcc agaagcgagt ccctaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgat      900

gaggacttca gctga                                                       915


<210>  96
<211>  615
<212>  DNA
<213>  Bos taurus

<400>  96
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gctgagtcgg       60

caggaggcgg tggcgctgtt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcactagcc ccggggacta tgtgctcagc gtctccgaga actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgccca gcctccgccc      240

ggggtgagtc cctccagact ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacgt tgatagaacc agtttccaga      360

tccaggcagg gtagtggagt gattctcagg caggaagagg cagagtatgt acgagccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg      540

atgattccag tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  97
<211>  304
<212>  PRT
<213>  Bos taurus

<400>  97

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  98
<211>  204
<212>  PRT
<213>  Bos taurus

<400>  98

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  99
<211>  792
<212>  DNA
<213>  Mus musculus

<400>  99
atggcgggca acttcgactc ggaggagcgg agtagctggt actggggccg cctgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgcttagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacat tgatagaacc agtggccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catttatgcc      720

agggttatcc agaagcgagt ccctaatgcc tacgacaaga cagccttggc tttggagctc      780

ctgatggttt ga                                                          792


<210>  100
<211>  786
<212>  DNA
<213>  Mus musculus

<400>  100
atggcgggca acttcgactc ggaggagcgg agtagctggt actggggccg cctgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgcttagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacat tgatagaacc agtggccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggagctc ctgatggttt gatctctcta ctaaggactt acgagtttaa aaagcaaatt      660

ttatatttaa gatactgttc ttcttgggct ggacagatgg ctcagcggtt aagagcattg      720

actgctcttc cgaaggccct gagttcaaat cccagcaacc acatggtggc tcacaaccat      780

ctgtaa                                                                 786


<210>  101
<211>  615
<212>  DNA
<213>  Mus musculus

<400>  101
atggcgggca acttcgactc ggaggagcgg agtagctggt actggggccg cctgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgcttagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacat tgatagaacc agtggccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  102
<211>  915
<212>  DNA
<213>  Mus musculus

<400>  102
atggcgggca acttcgactc ggaggagcgg agtagctggt actggggccg cctgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgcttagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacat tgatagaacc agtggccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacctgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catttatgcc      720

agggttatcc agaagcgagt ccctaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgat      900

gaggacttca gctga                                                       915


<210>  103
<211>  249
<212>  DNA
<213>  Mus musculus

<400>  103
atggcgggca acttcgactc ggaggagcgg agtagctggt actggggccg cctgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg tgttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgcttagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggtcggtga                                                              249


<210>  104
<211>  263
<212>  PRT
<213>  Mus musculus

<400>  104

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ala Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Leu Leu Met Val 
            260             


<210>  105
<211>  261
<212>  PRT
<213>  Mus musculus

<400>  105

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ala Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Ala Pro Asp Gly Leu Ile 
        195                 200                 205             


Ser Leu Leu Arg Thr Tyr Glu Phe Lys Lys Gln Ile Leu Tyr Leu Arg 
    210                 215                 220                 


Tyr Cys Ser Ser Trp Ala Gly Gln Met Ala Gln Arg Leu Arg Ala Leu 
225                 230                 235                 240 


Thr Ala Leu Pro Lys Ala Leu Ser Ser Asn Pro Ser Asn His Met Val 
                245                 250                 255     


Ala His Asn His Leu 
            260     


<210>  106
<211>  204
<212>  PRT
<213>  Mus musculus

<400>  106

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ala Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  107
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  107

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ala Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210>  108
<211>  82
<212>  PRT
<213>  Mus musculus

<400>  108

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Arg 
        


<210>  109
<211>  915
<212>  DNA
<213>  Rattus norvegicus

<400>  109
atggcaggca acttcgactc ggaggagcgg agtagctggt actggggccg cttgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg ttttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacac tgatagaacc agtttccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacccgcct ccgcctcagt atcggctctg      600

attggaggta accaggaggg ttcccaccca cagccactgg gtgggccgga gcctgggccc      660

tatgcccaac ccagcgtcaa cactccgctc cctaacctcc agaatgggcc catttatgcc      720

agggttatcc agaagcgagt ccctaatgcc tacgacaaga cagccttggc tttggaggtc      780

ggtgagctgg taaaggttac gaagattaat gtgagtggtc agtgggaagg ggagtgtaat      840

ggcaaacgag gtcacttccc attcacacat gtccgtctgc tggatcaaca gaatcccgag      900

gaggacttca gctga                                                       915


<210>  110
<211>  615
<212>  DNA
<213>  Rattus norvegicus

<400>  110
atggcaggca acttcgactc ggaggagcgg agtagctggt actggggccg cttgagccgg       60

caggaggcgg tggcgctatt gcagggccag cggcacgggg ttttcctggt gcgggactcg      120

agcaccagcc ccggggacta tgtgctcagc gtctccgaaa actcgcgcgt ctcccactac      180

atcatcaaca gcagcggccc gcgccctcca gtgcctccgt cgcccgctca gcctccgccg      240

ggagtgagtc cctccaggct ccgaatagga gatcaagaat ttgattcatt gcctgcttta      300

ctggaattct acaaaataca ctatttggac actacaacac tgatagaacc agtttccaga      360

tcaaggcagg gtagtggagt gattctcagg caggaggagg cagagtatgt gcgggccctc      420

tttgacttta atgggaatga tgaagaagat cttcccttta agaaaggaga catcctgaga      480

atccgggata agcctgaaga gcagtggtgg aatgcagagg acagcgaagg aaagaggggg      540

atgattcctg tcccttacgt ggagaagtat agacccgcct ccgcctcagt atcggctctg      600

attggaggtc ggtga                                                       615


<210>  111
<211>  304
<212>  PRT
<213>  Rattus norvegicus

<400>  111

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Glu Glu Asp Phe Ser 
    290                 295                 300                 


<210>  112
<211>  204
<212>  PRT
<213>  Rattus norvegicus

<400>  112

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  113
<211>  918
<212>  DNA
<213>  Gallus gallus

<400>  113
atggccgggc agttcgactc cgaggaccgg gggagctggt actgggggcg gctgagccgg       60

ggcgacgcgg tgtcgctgct gcaggggcaa cgccacggga ccttcctggt gcgcgactcg      120

ggctccatcc ccggcgactt cgtgctctcg gtgtccgaga gctcccgcgt ctcgcactac      180

atcgtcaaca gcctggggcc ggcgggaggc cggagggccg gcggcgaggg ccctggggcc      240

ccggggttga atcccaccag atttcgaata ggtgaccagg agtttgattc tttgccatct      300

ttactggaat tctacaaaat acactatttg gacactacaa ccttgataga accagtttcc      360

cgatccaggc agaacagtgg cgttatcctc aggcaggagg aagttgaata tgtgcgagct      420

ctctttgact ttaatggaaa cgatgacgaa gatcttccat ttaagaaagg agacatactg      480

aaaatccggg ataaacctga agagcaatgg tggaatgcag aagacatgga tggaaagagg      540

ggaatgatac ctgttcctta cgtcgagaag tgtagacctt cctctgcttc agtatctact      600

ctgactggag gtaaccagga tagttcccac ccacaaccac tgggtgggcc ggagccaggg      660

ccctatgccc agcccagcat caacactccg ctccctaacc ttcagaatgg ccctttttat      720

gcccgggtta tccagaagcg agtccctaat gcctacgaca agacagcctt ggctttggag      780

gtcggtgagc tggtaaaggt cacgaagatt aacatgagtg gtcagtggga aggagaatgt      840

aatggcaaac gtggtcactt tccattcaca catgtccgcc tgctggatca acagaatcct      900

gatgaggact tcagctga                                                    918


<210>  114
<211>  305
<212>  PRT
<213>  Gallus gallus

<400>  114

Met Ala Gly Gln Phe Asp Ser Glu Asp Arg Gly Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gly Asp Ala Val Ser Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Thr Phe Leu Val Arg Asp Ser Gly Ser Ile Pro Gly Asp Phe Val 
        35                  40                  45              


Leu Ser Val Ser Glu Ser Ser Arg Val Ser His Tyr Ile Val Asn Ser 
    50                  55                  60                  


Leu Gly Pro Ala Gly Gly Arg Arg Ala Gly Gly Glu Gly Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Leu Asn Pro Thr Arg Phe Arg Ile Gly Asp Gln Glu Phe Asp 
                85                  90                  95      


Ser Leu Pro Ser Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr 
            100                 105                 110         


Thr Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Asn Ser Gly Val 
        115                 120                 125             


Ile Leu Arg Gln Glu Glu Val Glu Tyr Val Arg Ala Leu Phe Asp Phe 
    130                 135                 140                 


Asn Gly Asn Asp Asp Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu 
145                 150                 155                 160 


Lys Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Met 
                165                 170                 175     


Asp Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Cys Arg 
            180                 185                 190         


Pro Ser Ser Ala Ser Val Ser Thr Leu Thr Gly Gly Asn Gln Asp Ser 
        195                 200                 205             


Ser His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln 
    210                 215                 220                 


Pro Ser Ile Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Phe Tyr 
225                 230                 235                 240 


Ala Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala 
                245                 250                 255     


Leu Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Met 
            260                 265                 270         


Ser Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro 
        275                 280                 285             


Phe Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe 
    290                 295                 300                 


Ser 
305 


<210>  115
<211>  891
<212>  DNA
<213>  Xenopus tropicalis

<400>  115
atggcgggca acttcgactc cgaggaccgg gcgagctggt actggggcaa gctgaacaga       60

caagaggcgg tcaatcttct gcagggccag cggcacggtg tgtttttagt tcgagactcc      120

acaactatac ctggtgacta cgtattgtct gtctctgaga actccaaggt ttcccactat      180

atcatcaaca gcgtcagcaa caaccggcag agtgggactg gaatgatcca gtcccgattc      240

agaataggtg accaagagtt tgattcctta ccatctcttt tggaatttta taagatccat      300

tacctggaca ctacaacttt aatagaacca gtttccaagt ctaaacaatc tggtgtaatc      360

caaagacaag aagaagttga atacgtgcga gctctctttg actttaatgg caatgatgat      420

gaagatcttc catttaagaa aggagacatc ctgagaattc gagataagcc cgaggagcag      480

tggtggaatg ctgaggacaa cgatggaaga cggggcatga tacctgtgcc ttacgtcgag      540

aagtacaggc ctccctcttc agcagggtca gccctgattg gaggtaacca ggaaaactcg      600

cacccgcaac cactgggtgg gccggagcca gggccctatg cccagcccag cgtcaacact      660

ccgctgccta accttcagaa tgggcccatt tttgccaggg ttatccagaa gcgcgtccct      720

aatgcctacg acaagacagc cttggctttg gaggttggtg atctagtaaa ggtaacaaag      780

attaatgtca gtggccagtg ggaaggagag tgcaacggga aatatggtca ttttccattt      840

acacatgtgc gtctgctgga tcaacagaac ccagaggagg actttagctg a               891


<210>  116
<211>  591
<212>  DNA
<213>  Xenopus tropicalis

<400>  116
atggcgggca acttcgactc cgaggaccgg gcgagctggt actggggcaa gctgaacaga       60

caagaggcgg tcaatcttct gcagggccag cggcacggtg tgtttttagt tcgagactcc      120

acaactatac ctggtgacta cgtattgtct gtctctgaga actccaaggt ttcccactat      180

atcatcaaca gcgtcagcaa caaccggcag agtgggactg gaatgatcca gtcccgattc      240

agaataggtg accaagagtt tgattcctta ccatctcttt tggaatttta taagatacat      300

tacctggaca ctacaacttt aatagaacca gtttccaagt ctaaacaatc tggtgtaatc      360

caaagacaag aagaagttga atacgtgcga gctctctttg actttaatgg caatgatgat      420

gaagatcttc catttaagaa aggagacatc ctgagaattc gagataagcc cgaggagcag      480

tggtggaatg ctgaggacaa cgatggaaga cggggcatga tacctgtgcc ttacgtcgag      540

aagtacaggc ctccctcttc agcagggtca gccctgattg gaggttggtg a               591


<210>  117
<211>  296
<212>  PRT
<213>  Xenopus tropicalis

<400>  117

Met Ala Gly Asn Phe Asp Ser Glu Asp Arg Ala Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Lys Leu Asn Arg Gln Glu Ala Val Asn Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Thr Thr Ile Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Lys Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Val Ser Asn Asn Arg Gln Ser Gly Thr Gly Met Ile Gln Ser Arg Phe 
65                  70                  75                  80  


Arg Ile Gly Asp Gln Glu Phe Asp Ser Leu Pro Ser Leu Leu Glu Phe 
                85                  90                  95      


Tyr Lys Ile His Tyr Leu Asp Thr Thr Thr Leu Ile Glu Pro Val Ser 
            100                 105                 110         


Lys Ser Lys Gln Ser Gly Val Ile Gln Arg Gln Glu Glu Val Glu Tyr 
        115                 120                 125             


Val Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp Asp Glu Asp Leu Pro 
    130                 135                 140                 


Phe Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln 
145                 150                 155                 160 


Trp Trp Asn Ala Glu Asp Asn Asp Gly Arg Arg Gly Met Ile Pro Val 
                165                 170                 175     


Pro Tyr Val Glu Lys Tyr Arg Pro Pro Ser Ser Ala Gly Ser Ala Leu 
            180                 185                 190         


Ile Gly Gly Asn Gln Glu Asn Ser His Pro Gln Pro Leu Gly Gly Pro 
        195                 200                 205             


Glu Pro Gly Pro Tyr Ala Gln Pro Ser Val Asn Thr Pro Leu Pro Asn 
    210                 215                 220                 


Leu Gln Asn Gly Pro Ile Phe Ala Arg Val Ile Gln Lys Arg Val Pro 
225                 230                 235                 240 


Asn Ala Tyr Asp Lys Thr Ala Leu Ala Leu Glu Val Gly Asp Leu Val 
                245                 250                 255     


Lys Val Thr Lys Ile Asn Val Ser Gly Gln Trp Glu Gly Glu Cys Asn 
            260                 265                 270         


Gly Lys Tyr Gly His Phe Pro Phe Thr His Val Arg Leu Leu Asp Gln 
        275                 280                 285             


Gln Asn Pro Glu Glu Asp Phe Ser 
    290                 295     


<210>  118
<211>  196
<212>  PRT
<213>  Xenopus tropicalis

<400>  118

Met Ala Gly Asn Phe Asp Ser Glu Asp Arg Ala Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Lys Leu Asn Arg Gln Glu Ala Val Asn Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Thr Thr Ile Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Lys Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Val Ser Asn Asn Arg Gln Ser Gly Thr Gly Met Ile Gln Ser Arg Phe 
65                  70                  75                  80  


Arg Ile Gly Asp Gln Glu Phe Asp Ser Leu Pro Ser Leu Leu Glu Phe 
                85                  90                  95      


Tyr Lys Ile His Tyr Leu Asp Thr Thr Thr Leu Ile Glu Pro Val Ser 
            100                 105                 110         


Lys Ser Lys Gln Ser Gly Val Ile Gln Arg Gln Glu Glu Val Glu Tyr 
        115                 120                 125             


Val Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp Asp Glu Asp Leu Pro 
    130                 135                 140                 


Phe Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln 
145                 150                 155                 160 


Trp Trp Asn Ala Glu Asp Asn Asp Gly Arg Arg Gly Met Ile Pro Val 
                165                 170                 175     


Pro Tyr Val Glu Lys Tyr Arg Pro Pro Ser Ser Ala Gly Ser Ala Leu 
            180                 185                 190         


Ile Gly Gly Trp 
        195     


<210>  119
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  119
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggattctt cataa                                                       195


<210>  120
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  120
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggtactat gccaatcaga atggctcaaa taccaaggga agtgttattg gttctctaat      240

gagatgaaaa gctggagtga cagttatgtg tattgtttgg aaagaaaatc tcatctacta      300

atcatacatg accaacttga aatggctttt atacagaaaa acctaagaca attaaactac      360

gtatggattg ggcttaactt tacctccttg aaaatgacat ggacttgggt ggatggttct      420

ccaatagatt caaagatatt cttcataaag ggaccagcta aagaaaacag ctgtgctgcc      480

attaaggaaa gcaaaatttt ctctgaaacc tgcagcagtg ttttcaaatg gatttgtcag      540

tattag                                                                 546


<210>  121
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  121
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggtttctc agggagtatt gctaaaatgc caaaaaggaa gttgttcaaa tgccactcag      240

tatgaggaca ctggagatct aaaagtgaat aatggcacaa gaagaaatat aagtaataag      300

gacctttgtg cttcgagatc tgcagaccag acagtactat gccaatcaga atggctcaaa      360

taccaaggga agtgttattg gttctctaat gagatgaaaa gctggagtga cagttatgtg      420

tattgtttgg aaagaaaatc tcatctacta atcatacatg accaacttga aatggctttt      480

atacagaaaa acctaagaca attaaactac gtatggattg ggcttaactt tacctccttg      540

aaaatgacat ggacttgggt ggatggttct ccaatagatt caaagatatt cttcataaag      600

ggaccagcta aagaaaacag ctgtgctgcc attaaggaaa gcaaaatttt ctctgaaacc      660

tgcagcagtg ttttcaaatg gatttgtcag tattag                                696


<210>  122
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln 
    50                  55                  60                  


Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln 
65                  70                  75                  80  


Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn 
                85                  90                  95      


Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val 
            100                 105                 110         


Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe 
        115                 120                 125             


Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu 
    130                 135                 140                 


Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe 
145                 150                 155                 160 


Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn 
                165                 170                 175     


Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile 
            180                 185                 190         


Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys 
        195                 200                 205             


Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
    210                 215                 220                 


Phe Lys Trp Ile Cys Gln Tyr 
225                 230     


<210>  123
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Asp Ser Ser 
    50                  55                  60                  


<210>  124
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Leu Cys 
    50                  55                  60                  


Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe Ser Asn 
65                  70                  75                  80  


Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu Arg Lys 
                85                  90                  95      


Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe Ile Gln 
            100                 105                 110         


Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn Phe Thr 
        115                 120                 125             


Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile Asp Ser 
    130                 135                 140                 


Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys Ala Ala 
145                 150                 155                 160 


Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val Phe Lys 
                165                 170                 175     


Trp Ile Cys Gln Tyr 
            180     


<210>  125
<211>  1545
<212>  DNA
<213>  Homo sapiens

<400>  125
atggctgata gtggcttaga taaaaaatcc acaaaatgcc ccgactgttc atctgcttct       60

cagaaagatg tactttgtgt atgttccagc aaaacaaggg ttcctccagt tttggtggtg      120

gaaatgtcac agacatcaag cattggtagt gcagaatctt taatttcact ggagagaaaa      180

aaagaaaaaa atatcaacag agatataacc tccaggaaag atttgccctc aagaacctca      240

aatgtagaga gaaaagcatc tcagcaacaa tggggtcggg gcaactttac agaaggaaaa      300

gttcctcaca taaggattga gaatggagct gctattgagg aaatctatac ctttggaaga      360

atattgggaa aagggagctt tggaatagtc attgaagcga cagacaagga aacagaaacg      420

aagtgggcaa ttaaaaaagt gaacaaagaa aaggctggaa gctctgctgt gaagttactt      480

gaacgagagg tgaacattct gaaaagtgta aaacatgaac acatcataca tctggaacaa      540

gtatttgaaa cgccaaagaa aatgtacctt gtgatggagc tttgtgagga tggagaactc      600

aaagaaattc tggataggaa agggcatttc tcagagaatg agacaaggtg gatcattcaa      660

agtctcgcat cagctatagc atatcttcac aataatgata ttgtacatag agatctgaaa      720

ctggaaaata taatggttaa aagcagtctt attgatgata acaatgaaat aaacttaaac      780

ataaaggtga ctgattttgg cttagcggtg aagaagcaaa gtaggagtga agccatgctg      840

caggccacat gtgggactcc tatctatatg gcccctgaag ttatcagtgc ccacgactat      900

agccagcagt gtgacatttg gagcataggc gtcgtaatgt acatgttatt acgtggagaa      960

ccaccctttt tggcaagctc agaagagaag ctttttgagt taataagaaa aggagaacta     1020

cattttgaaa atgcagtctg gaattccata agtgactgtg ctaaaagtgt tttgaaacaa     1080

cttatgaaag tagatcctgc tcacagaatc acagctaagg aactactaga taaccagtgg     1140

ttaacaggca ataaactttc ttcggtgaga ccaaccaatg tattagagat gatgaaggaa     1200

tggaaaaata acccagaaag tgttgaggaa aacacaacag aagagaagaa taagccgtcc     1260

actgaagaaa agttgaaaag ttaccaaccc tggggaaatg tccctgatgc caattacact     1320

tcagatgaag aggaggaaaa acagtctact gcttatgaaa agcaatttcc tgcaaccagt     1380

aaggacaact ttgatatgtg cagttcaagt ttcacatcta gcaaactcct tccagctgaa     1440

atcaagggag aaatggagaa aacccctgtg actccaagcc aaggaacagc aaccaagtac     1500

cctgctaaat ccggcgccct gtccagaacc aaaaagaaac tctaa                     1545


<210>  126
<211>  1422
<212>  DNA
<213>  Homo sapiens

<400>  126
atgtcacaga catcaagcat tggtagtgca gaatctttaa tttcactgga gagaaaaaaa       60

gaaaaaaata tcaacagaga tataacctcc aggaaagatt tgccctcaag aacctcaaat      120

gtagagagaa aagcatctca gcaacaatgg ggtcggggca actttacaga aggaaaagtt      180

cctcacataa ggattgagaa tggagctgct attgaggaaa tctatacctt tggaagaata      240

ttgggaaaag ggagctttgg aatagtcatt gaagcgacag acaaggaaac agaaacgaag      300

tgggcaatta aaaaagtgaa caaagaaaag gctggaagct ctgctgtgaa gttacttgaa      360

cgagaggtga acattctgaa aagtgtaaaa catgaacaca tcatacatct ggaacaagta      420

tttgaaacgc caaagaaaat gtaccttgtg atggagcttt gtgaggatgg agaactcaaa      480

gaaattctgg ataggaaagg gcatttctca gagaatgaga caaggtggat cattcaaagt      540

ctcgcatcag ctatagcata tcttcacaat aatgatattg tacatagaga tctgaaactg      600

gaaaatataa tggttaaaag cagtcttatt gatgataaca atgaaataaa cttaaacata      660

aaggtgactg attttggctt agcggtgaag aagcaaagta ggagtgaagc catgctgcag      720

gccacatgtg ggactcctat ctatatggcc cctgaagtta tcagtgccca cgactatagc      780

cagcagtgtg acatttggag cataggcgtc gtaatgtaca tgttattacg tggagaacca      840

ccctttttgg caagctcaga agagaagctt tttgagttaa taagaaaagg agaactacat      900

tttgaaaatg cagtctggaa ttccataagt gactgtgcta aaagtgtttt gaaacaactt      960

atgaaagtag atcctgctca cagaatcaca gctaaggaac tactagataa ccagtggtta     1020

acaggcaata aactttcttc ggtgagacca accaatgtat tagagatgat gaaggaatgg     1080

aaaaataacc cagaaagtgt tgaggaaaac acaacagaag agaagaataa gccgtccact     1140

gaagaaaagt tgaaaagtta ccaaccctgg ggaaatgtcc ctgatgccaa ttacacttca     1200

gatgaagagg aggaaaaaca gtctactgct tatgaaaagc aatttcctgc aaccagtaag     1260

gacaactttg atatgtgcag ttcaagtttc acatctagca aactccttcc agctgaaatc     1320

aagggagaaa tggagaaaac ccctgtgact ccaagccaag gaacagcaac caagtaccct     1380

gctaaatccg gcgccctgtc cagaaccaaa aagaaactct aa                        1422


<210>  127
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  127
atgtaccttg tgatggagct ttgtgaggat ggagaactca aagaaattct ggataggaaa       60

gggcatttct cagagaatga gacaaggtgg atcattcaaa gtctcgcatc agctatagca      120

tatcttcaca ataatgatat tgtacataga gatctgaaac tggaaaatat aatggttaaa      180

agcagtctta ttgatgataa caatgaaata aacttaaaca taaaggtgac tgattttggc      240

ttagcggtga agaagcaaag taggagtgaa gccatgctgc aggccacatg tgggactcct      300

atctatatgg cccctgaagt tatcagtgcc cacgactata gccagcagtg tgacatttgg      360

agcataggcg tcgtaatgta catgttatta cgtggagaac cacccttttt ggcaagctca      420

gaagagaagc tttttgagtt aataagaaaa ggagaactac attttgaaaa tgcagtctgg      480

aattccataa gtgactgtgc taaaagtgtt ttgaaacaac ttatgaaagt agatcctgct      540

cacagaatca cagctaagga actactagat aaccagtggt taacaggcaa taaactttct      600

tcggtgagac caaccaatgt attagagatg atgaaggaat ggaaaaataa cccagaaagt      660

gttgaggaaa acacaacaga agagaagaat aagccgtcca ctgaagaaaa gttgaaaagt      720

taccaaccct ggggaaatgt ccctgatgcc aattacactt cagatgaaga ggaggaaaaa      780

cagtctactg cttatgaaaa gcaatttcct gcaaccagta aggacaactt tgatatgtgc      840

agttcaagtt tcacatctag caaactcctt ccagctgaaa tcaagggaga aatggagaaa      900

acccctgtga ctccaagcca aggaacagca accaagtacc ctgctaaatc cggcgccctg      960

tccagaacca aaaagaaact ctaa                                             984


<210>  128
<211>  1545
<212>  DNA
<213>  Homo sapiens

<400>  128
atggctgata gtggcttaga taaaaaatcc acaaaatgcc ccgactgttc atctgcttct       60

cagaaagatg tactttgtgt atgttccagc aaaacaaggg ttcctccagt tttggtggtg      120

gaaatgtcac agacatcaag cattggtagt gcagaatctt taatttcact ggagagaaaa      180

aaagaaaaaa atatcaacag agatataacc tccaggaaag atttgccctc aagaacctca      240

aatgtagaga gaaaagcatc tcagcaacaa tggggtcggg gcaactttac agaaggaaaa      300

gttcctcaca taaggattga gaatggagct gctattgagg aaatctatac ctttggaaga      360

atattgggaa aagggagctt tggaatagtc attgaagcga cagacaagga aacagaaacg      420

aagtgggcaa ttaaaaaagt gaacaaagaa aaggctggaa gctctgctgt gaagttactt      480

gaacgagagg tgaacattct gaaaagtgta aaacatgaac acatcataca tctggaacaa      540

gtatttgaaa cgccaaagaa aatgtacctt gtgatggagc tttgtgagga tggagaactc      600

aaagaaattc tggataggaa agggcatttc tcagagaatg agacaaggtg gatcattcaa      660

agtctcgcat cagctatagc atatcttcac aataatgata ttgtacatag agatctgaaa      720

ctggaaaata taatggttaa aagcagtctt attgatgata acaatgaaat aaacttaaac      780

ataaaggtga ctgattttgg cttagcggtg aagaagcaaa gtaggagtga agccatgctg      840

caggccacat gtgggactcc tatctatatg gcccctgaag ttatcagtgc ccacgactat      900

agccagcagt gtgacatttg gagcataggc gtcgtaatgt acatgttatt acgtggagaa      960

ccaccctttt tggcaagctc agaagagaag ctttttgagt taataagaaa aggagaacta     1020

cattttgaaa atgcagtctg gaattccata agtgactgtg ctaaaagtgt tttgaaacaa     1080

cttatgaaag tagatcctgc tcacagaatc acagctaagg aactactaga taaccagtgg     1140

ttaacaggca ataaactttc ttcggtgaga ccaaccaatg tattagagat gatgaaggaa     1200

tggaaaaata acccagaaag tgttgaggaa aacacaacag aagagaagaa taagccgtcc     1260

actgaagaaa agttgaaaag ttaccaaccc tggggaaatg tccctgatgc caattacact     1320

tcagatgaag aggaggaaaa acagtctact gcttatgaaa agcaatttcc tgcaaccagt     1380

aaggacaact ttgatatgtg cagttcaagt ttcacatcta gcaaactcct tccagctgaa     1440

atcaagggag aaatggagaa aacccctgtg actccaagcc aaggaacagc aaccaagtac     1500

cctgctaaat ccggcgccct gtccagaacc aaaaagaaac tctaa                     1545


<210>  129
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ala Asp Ser Gly Leu Asp Lys Lys Ser Thr Lys Cys Pro Asp Cys 
1               5                   10                  15      


Ser Ser Ala Ser Gln Lys Asp Val Leu Cys Val Cys Ser Ser Lys Thr 
            20                  25                  30          


Arg Val Pro Pro Val Leu Val Val Glu Met Ser Gln Thr Ser Ser Ile 
        35                  40                  45              


Gly Ser Ala Glu Ser Leu Ile Ser Leu Glu Arg Lys Lys Glu Lys Asn 
    50                  55                  60                  


Ile Asn Arg Asp Ile Thr Ser Arg Lys Asp Leu Pro Ser Arg Thr Ser 
65                  70                  75                  80  


Asn Val Glu Arg Lys Ala Ser Gln Gln Gln Trp Gly Arg Gly Asn Phe 
                85                  90                  95      


Thr Glu Gly Lys Val Pro His Ile Arg Ile Glu Asn Gly Ala Ala Ile 
            100                 105                 110         


Glu Glu Ile Tyr Thr Phe Gly Arg Ile Leu Gly Lys Gly Ser Phe Gly 
        115                 120                 125             


Ile Val Ile Glu Ala Thr Asp Lys Glu Thr Glu Thr Lys Trp Ala Ile 
    130                 135                 140                 


Lys Lys Val Asn Lys Glu Lys Ala Gly Ser Ser Ala Val Lys Leu Leu 
145                 150                 155                 160 


Glu Arg Glu Val Asn Ile Leu Lys Ser Val Lys His Glu His Ile Ile 
                165                 170                 175     


His Leu Glu Gln Val Phe Glu Thr Pro Lys Lys Met Tyr Leu Val Met 
            180                 185                 190         


Glu Leu Cys Glu Asp Gly Glu Leu Lys Glu Ile Leu Asp Arg Lys Gly 
        195                 200                 205             


His Phe Ser Glu Asn Glu Thr Arg Trp Ile Ile Gln Ser Leu Ala Ser 
    210                 215                 220                 


Ala Ile Ala Tyr Leu His Asn Asn Asp Ile Val His Arg Asp Leu Lys 
225                 230                 235                 240 


Leu Glu Asn Ile Met Val Lys Ser Ser Leu Ile Asp Asp Asn Asn Glu 
                245                 250                 255     


Ile Asn Leu Asn Ile Lys Val Thr Asp Phe Gly Leu Ala Val Lys Lys 
            260                 265                 270         


Gln Ser Arg Ser Glu Ala Met Leu Gln Ala Thr Cys Gly Thr Pro Ile 
        275                 280                 285             


Tyr Met Ala Pro Glu Val Ile Ser Ala His Asp Tyr Ser Gln Gln Cys 
    290                 295                 300                 


Asp Ile Trp Ser Ile Gly Val Val Met Tyr Met Leu Leu Arg Gly Glu 
305                 310                 315                 320 


Pro Pro Phe Leu Ala Ser Ser Glu Glu Lys Leu Phe Glu Leu Ile Arg 
                325                 330                 335     


Lys Gly Glu Leu His Phe Glu Asn Ala Val Trp Asn Ser Ile Ser Asp 
            340                 345                 350         


Cys Ala Lys Ser Val Leu Lys Gln Leu Met Lys Val Asp Pro Ala His 
        355                 360                 365             


Arg Ile Thr Ala Lys Glu Leu Leu Asp Asn Gln Trp Leu Thr Gly Asn 
    370                 375                 380                 


Lys Leu Ser Ser Val Arg Pro Thr Asn Val Leu Glu Met Met Lys Glu 
385                 390                 395                 400 


Trp Lys Asn Asn Pro Glu Ser Val Glu Glu Asn Thr Thr Glu Glu Lys 
                405                 410                 415     


Asn Lys Pro Ser Thr Glu Glu Lys Leu Lys Ser Tyr Gln Pro Trp Gly 
            420                 425                 430         


Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp Glu Glu Glu Glu Lys Gln 
        435                 440                 445             


Ser Thr Ala Tyr Glu Lys Gln Phe Pro Ala Thr Ser Lys Asp Asn Phe 
    450                 455                 460                 


Asp Met Cys Ser Ser Ser Phe Thr Ser Ser Lys Leu Leu Pro Ala Glu 
465                 470                 475                 480 


Ile Lys Gly Glu Met Glu Lys Thr Pro Val Thr Pro Ser Gln Gly Thr 
                485                 490                 495     


Ala Thr Lys Tyr Pro Ala Lys Ser Gly Ala Leu Ser Arg Thr Lys Lys 
            500                 505                 510         


Lys Leu 
        


<210>  130
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ala Asp Ser Gly Leu Asp Lys Lys Ser Thr Lys Cys Pro Asp Cys 
1               5                   10                  15      


Ser Ser Ala Ser Gln Lys Asp Val Leu Cys Val Cys Ser Ser Lys Thr 
            20                  25                  30          


Arg Val Pro Pro Val Leu Val Val Glu Met Ser Gln Thr Ser Ser Ile 
        35                  40                  45              


Gly Ser Ala Glu Ser Leu Ile Ser Leu Glu Arg Lys Lys Glu Lys Asn 
    50                  55                  60                  


Ile Asn Arg Asp Ile Thr Ser Arg Lys Asp Leu Pro Ser Arg Thr Ser 
65                  70                  75                  80  


Asn Val Glu Arg Lys Ala Ser Gln Gln Gln Trp Gly Arg Gly Asn Phe 
                85                  90                  95      


Thr Glu Gly Lys Val Pro His Ile Arg Ile Glu Asn Gly Ala Ala Ile 
            100                 105                 110         


Glu Glu Ile Tyr Thr Phe Gly Arg Ile Leu Gly Lys Gly Ser Phe Gly 
        115                 120                 125             


Ile Val Ile Glu Ala Thr Asp Lys Glu Thr Glu Thr Lys Trp Ala Ile 
    130                 135                 140                 


Lys Lys Val Asn Lys Glu Lys Ala Gly Ser Ser Ala Val Lys Leu Leu 
145                 150                 155                 160 


Glu Arg Glu Val Asn Ile Leu Lys Ser Val Lys His Glu His Ile Ile 
                165                 170                 175     


His Leu Glu Gln Val Phe Glu Thr Pro Lys Lys Met Tyr Leu Val Met 
            180                 185                 190         


Glu Leu Cys Glu Asp Gly Glu Leu Lys Glu Ile Leu Asp Arg Lys Gly 
        195                 200                 205             


His Phe Ser Glu Asn Glu Thr Arg Trp Ile Ile Gln Ser Leu Ala Ser 
    210                 215                 220                 


Ala Ile Ala Tyr Leu His Asn Asn Asp Ile Val His Arg Asp Leu Lys 
225                 230                 235                 240 


Leu Glu Asn Ile Met Val Lys Ser Ser Leu Ile Asp Asp Asn Asn Glu 
                245                 250                 255     


Ile Asn Leu Asn Ile Lys Val Thr Asp Phe Gly Leu Ala Val Lys Lys 
            260                 265                 270         


Gln Ser Arg Ser Glu Ala Met Leu Gln Ala Thr Cys Gly Thr Pro Ile 
        275                 280                 285             


Tyr Met Ala Pro Glu Val Ile Ser Ala His Asp Tyr Ser Gln Gln Cys 
    290                 295                 300                 


Asp Ile Trp Ser Ile Gly Val Val Met Tyr Met Leu Leu Arg Gly Glu 
305                 310                 315                 320 


Pro Pro Phe Leu Ala Ser Ser Glu Glu Lys Leu Phe Glu Leu Ile Arg 
                325                 330                 335     


Lys Gly Glu Leu His Phe Glu Asn Ala Val Trp Asn Ser Ile Ser Asp 
            340                 345                 350         


Cys Ala Lys Ser Val Leu Lys Gln Leu Met Lys Val Asp Pro Ala His 
        355                 360                 365             


Arg Ile Thr Ala Lys Glu Leu Leu Asp Asn Gln Trp Leu Thr Gly Asn 
    370                 375                 380                 


Lys Leu Ser Ser Val Arg Pro Thr Asn Val Leu Glu Met Met Lys Glu 
385                 390                 395                 400 


Trp Lys Asn Asn Pro Glu Ser Val Glu Glu Asn Thr Thr Glu Glu Lys 
                405                 410                 415     


Asn Lys Pro Ser Thr Glu Glu Lys Leu Lys Ser Tyr Gln Pro Trp Gly 
            420                 425                 430         


Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp Glu Glu Glu Glu Lys Gln 
        435                 440                 445             


Ser Thr Ala Tyr Glu Lys Gln Phe Pro Ala Thr Ser Lys Asp Asn Phe 
    450                 455                 460                 


Asp Met Cys Ser Ser Ser Phe Thr Ser Ser Lys Leu Leu Pro Ala Glu 
465                 470                 475                 480 


Ile Lys Gly Glu Met Glu Lys Thr Pro Val Thr Pro Ser Gln Gly Thr 
                485                 490                 495     


Ala Thr Lys Tyr Pro Ala Lys Ser Gly Ala Leu Ser Arg Thr Lys Lys 
            500                 505                 510         


Lys Leu 
        


<210>  131
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Tyr Leu Val Met Glu Leu Cys Glu Asp Gly Glu Leu Lys Glu Ile 
1               5                   10                  15      


Leu Asp Arg Lys Gly His Phe Ser Glu Asn Glu Thr Arg Trp Ile Ile 
            20                  25                  30          


Gln Ser Leu Ala Ser Ala Ile Ala Tyr Leu His Asn Asn Asp Ile Val 
        35                  40                  45              


His Arg Asp Leu Lys Leu Glu Asn Ile Met Val Lys Ser Ser Leu Ile 
    50                  55                  60                  


Asp Asp Asn Asn Glu Ile Asn Leu Asn Ile Lys Val Thr Asp Phe Gly 
65                  70                  75                  80  


Leu Ala Val Lys Lys Gln Ser Arg Ser Glu Ala Met Leu Gln Ala Thr 
                85                  90                  95      


Cys Gly Thr Pro Ile Tyr Met Ala Pro Glu Val Ile Ser Ala His Asp 
            100                 105                 110         


Tyr Ser Gln Gln Cys Asp Ile Trp Ser Ile Gly Val Val Met Tyr Met 
        115                 120                 125             


Leu Leu Arg Gly Glu Pro Pro Phe Leu Ala Ser Ser Glu Glu Lys Leu 
    130                 135                 140                 


Phe Glu Leu Ile Arg Lys Gly Glu Leu His Phe Glu Asn Ala Val Trp 
145                 150                 155                 160 


Asn Ser Ile Ser Asp Cys Ala Lys Ser Val Leu Lys Gln Leu Met Lys 
                165                 170                 175     


Val Asp Pro Ala His Arg Ile Thr Ala Lys Glu Leu Leu Asp Asn Gln 
            180                 185                 190         


Trp Leu Thr Gly Asn Lys Leu Ser Ser Val Arg Pro Thr Asn Val Leu 
        195                 200                 205             


Glu Met Met Lys Glu Trp Lys Asn Asn Pro Glu Ser Val Glu Glu Asn 
    210                 215                 220                 


Thr Thr Glu Glu Lys Asn Lys Pro Ser Thr Glu Glu Lys Leu Lys Ser 
225                 230                 235                 240 


Tyr Gln Pro Trp Gly Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp Glu 
                245                 250                 255     


Glu Glu Glu Lys Gln Ser Thr Ala Tyr Glu Lys Gln Phe Pro Ala Thr 
            260                 265                 270         


Ser Lys Asp Asn Phe Asp Met Cys Ser Ser Ser Phe Thr Ser Ser Lys 
        275                 280                 285             


Leu Leu Pro Ala Glu Ile Lys Gly Glu Met Glu Lys Thr Pro Val Thr 
    290                 295                 300                 


Pro Ser Gln Gly Thr Ala Thr Lys Tyr Pro Ala Lys Ser Gly Ala Leu 
305                 310                 315                 320 


Ser Arg Thr Lys Lys Lys Leu 
                325         


<210>  132
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Gln Thr Ser Ser Ile Gly Ser Ala Glu Ser Leu Ile Ser Leu 
1               5                   10                  15      


Glu Arg Lys Lys Glu Lys Asn Ile Asn Arg Asp Ile Thr Ser Arg Lys 
            20                  25                  30          


Asp Leu Pro Ser Arg Thr Ser Asn Val Glu Arg Lys Ala Ser Gln Gln 
        35                  40                  45              


Gln Trp Gly Arg Gly Asn Phe Thr Glu Gly Lys Val Pro His Ile Arg 
    50                  55                  60                  


Ile Glu Asn Gly Ala Ala Ile Glu Glu Ile Tyr Thr Phe Gly Arg Ile 
65                  70                  75                  80  


Leu Gly Lys Gly Ser Phe Gly Ile Val Ile Glu Ala Thr Asp Lys Glu 
                85                  90                  95      


Thr Glu Thr Lys Trp Ala Ile Lys Lys Val Asn Lys Glu Lys Ala Gly 
            100                 105                 110         


Ser Ser Ala Val Lys Leu Leu Glu Arg Glu Val Asn Ile Leu Lys Ser 
        115                 120                 125             


Val Lys His Glu His Ile Ile His Leu Glu Gln Val Phe Glu Thr Pro 
    130                 135                 140                 


Lys Lys Met Tyr Leu Val Met Glu Leu Cys Glu Asp Gly Glu Leu Lys 
145                 150                 155                 160 


Glu Ile Leu Asp Arg Lys Gly His Phe Ser Glu Asn Glu Thr Arg Trp 
                165                 170                 175     


Ile Ile Gln Ser Leu Ala Ser Ala Ile Ala Tyr Leu His Asn Asn Asp 
            180                 185                 190         


Ile Val His Arg Asp Leu Lys Leu Glu Asn Ile Met Val Lys Ser Ser 
        195                 200                 205             


Leu Ile Asp Asp Asn Asn Glu Ile Asn Leu Asn Ile Lys Val Thr Asp 
    210                 215                 220                 


Phe Gly Leu Ala Val Lys Lys Gln Ser Arg Ser Glu Ala Met Leu Gln 
225                 230                 235                 240 


Ala Thr Cys Gly Thr Pro Ile Tyr Met Ala Pro Glu Val Ile Ser Ala 
                245                 250                 255     


His Asp Tyr Ser Gln Gln Cys Asp Ile Trp Ser Ile Gly Val Val Met 
            260                 265                 270         


Tyr Met Leu Leu Arg Gly Glu Pro Pro Phe Leu Ala Ser Ser Glu Glu 
        275                 280                 285             


Lys Leu Phe Glu Leu Ile Arg Lys Gly Glu Leu His Phe Glu Asn Ala 
    290                 295                 300                 


Val Trp Asn Ser Ile Ser Asp Cys Ala Lys Ser Val Leu Lys Gln Leu 
305                 310                 315                 320 


Met Lys Val Asp Pro Ala His Arg Ile Thr Ala Lys Glu Leu Leu Asp 
                325                 330                 335     


Asn Gln Trp Leu Thr Gly Asn Lys Leu Ser Ser Val Arg Pro Thr Asn 
            340                 345                 350         


Val Leu Glu Met Met Lys Glu Trp Lys Asn Asn Pro Glu Ser Val Glu 
        355                 360                 365             


Glu Asn Thr Thr Glu Glu Lys Asn Lys Pro Ser Thr Glu Glu Lys Leu 
    370                 375                 380                 


Lys Ser Tyr Gln Pro Trp Gly Asn Val Pro Asp Ala Asn Tyr Thr Ser 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Lys Gln Ser Thr Ala Tyr Glu Lys Gln Phe Pro 
                405                 410                 415     


Ala Thr Ser Lys Asp Asn Phe Asp Met Cys Ser Ser Ser Phe Thr Ser 
            420                 425                 430         


Ser Lys Leu Leu Pro Ala Glu Ile Lys Gly Glu Met Glu Lys Thr Pro 
        435                 440                 445             


Val Thr Pro Ser Gln Gly Thr Ala Thr Lys Tyr Pro Ala Lys Ser Gly 
    450                 455                 460                 


Ala Leu Ser Arg Thr Lys Lys Lys Leu 
465                 470             


<210>  133
<211>  1476
<212>  DNA
<213>  Mus musculus

<400>  133
atggctgacc ccagcttgaa tgacaaccct acagcatgcc ctcactgtgc atcctctcag       60

gctggcctac tgtgtgtatg tccagcaggc aagtctccag tcctggtggt ggaaatgtca      120

cagacatcga gtattggtag tacagaattt tttgcttcac aagaaagaaa aaaggaaaga      180

aataccagca gagaatcttc tctaaaagat ttgtccataa gaacttcaaa tgtggagaga      240

aaacctcagg cacaatggag tcggagcaat gtcacagtag gaaaaatccc acacataaga      300

atggacgatg gagcaggtat cgaggaattc tatacctttg gaagaatatt gggacagggg      360

agctttggaa tggtctttga agctatagac aaggaaacag gagctaagtg ggcaattaaa      420

aaagtgaata aagaaaaggc tggaagttct gcaatgaagc tactggagcg ggaggtgagc      480

atcctgaaga ctgtcaacca tcaacacatc atccacctgg aacaagtgtt tgagtcgcct      540

cagaaaatgt atctcgtgat ggagctttgt gaggatggag aactcaaagc agttatggat      600

caaagagggc acttctcaga gaacgagaca aggctgataa ttcaaagtct tgcatcagcc      660

atcgcatatc ttcataacaa ggatatagtg cacagagatc taaagctgga aaacataatg      720

gttaaaagca gctttataga tgataacaat gaaatgaact taaacataaa ggtgactgat      780

tttggcttgt ctgtgcagaa gcatggctcc aggagtgaag gcatgatgca gactacatgt      840

gggactccta tctatatggc accagaggtc atcaatgccc atgactacag ccagcagtgt      900

gacatttgga gcataggtgt cataatgttc attttactgt gtggagagcc accctttttg      960

gcaaattcag aagaaaagct ctatgaatta ataaaaaagg gagaactacg atttgaaaat     1020

ccagtctggg aatctgtaag tgattctgca aaaaatactt tgaaacaact catgaaagta     1080

gatcctgctc acagaatcac agctaaggaa cttctagata accaatggtt gacaggcaat     1140

accctttctt cagcaagacc aaccaatgta ttagaaatga tgaaagaatg gaaaaataac     1200

ccagaaagtg atgaggagac caacacagat gaggagactg agcagagcgc tgtctacagt     1260

ccatctgcaa acacagcaaa gcagcccacc aatgcagcca agaagcctgc tgcagagagt     1320

gttggcatga cctcttcaaa ctcatcgtcc agcaaactcc tgtctgctga aagcaaagca     1380

gaaccagaga aaagctccga gactgtaggc catgcatcag tggctaaaac cactctgaaa     1440

tccactacct tgtttcgagg caagaaaagg ctctaa                               1476


<210>  134
<211>  491
<212>  PRT
<213>  Mus musculus

<400>  134

Met Ala Asp Pro Ser Leu Asn Asp Asn Pro Thr Ala Cys Pro His Cys 
1               5                   10                  15      


Ala Ser Ser Gln Ala Gly Leu Leu Cys Val Cys Pro Ala Gly Lys Ser 
            20                  25                  30          


Pro Val Leu Val Val Glu Met Ser Gln Thr Ser Ser Ile Gly Ser Thr 
        35                  40                  45              


Glu Phe Phe Ala Ser Gln Glu Arg Lys Lys Glu Arg Asn Thr Ser Arg 
    50                  55                  60                  


Glu Ser Ser Leu Lys Asp Leu Ser Ile Arg Thr Ser Asn Val Glu Arg 
65                  70                  75                  80  


Lys Pro Gln Ala Gln Trp Ser Arg Ser Asn Val Thr Val Gly Lys Ile 
                85                  90                  95      


Pro His Ile Arg Met Asp Asp Gly Ala Gly Ile Glu Glu Phe Tyr Thr 
            100                 105                 110         


Phe Gly Arg Ile Leu Gly Gln Gly Ser Phe Gly Met Val Phe Glu Ala 
        115                 120                 125             


Ile Asp Lys Glu Thr Gly Ala Lys Trp Ala Ile Lys Lys Val Asn Lys 
    130                 135                 140                 


Glu Lys Ala Gly Ser Ser Ala Met Lys Leu Leu Glu Arg Glu Val Ser 
145                 150                 155                 160 


Ile Leu Lys Thr Val Asn His Gln His Ile Ile His Leu Glu Gln Val 
                165                 170                 175     


Phe Glu Ser Pro Gln Lys Met Tyr Leu Val Met Glu Leu Cys Glu Asp 
            180                 185                 190         


Gly Glu Leu Lys Ala Val Met Asp Gln Arg Gly His Phe Ser Glu Asn 
        195                 200                 205             


Glu Thr Arg Leu Ile Ile Gln Ser Leu Ala Ser Ala Ile Ala Tyr Leu 
    210                 215                 220                 


His Asn Lys Asp Ile Val His Arg Asp Leu Lys Leu Glu Asn Ile Met 
225                 230                 235                 240 


Val Lys Ser Ser Phe Ile Asp Asp Asn Asn Glu Met Asn Leu Asn Ile 
                245                 250                 255     


Lys Val Thr Asp Phe Gly Leu Ser Val Gln Lys His Gly Ser Arg Ser 
            260                 265                 270         


Glu Gly Met Met Gln Thr Thr Cys Gly Thr Pro Ile Tyr Met Ala Pro 
        275                 280                 285             


Glu Val Ile Asn Ala His Asp Tyr Ser Gln Gln Cys Asp Ile Trp Ser 
    290                 295                 300                 


Ile Gly Val Ile Met Phe Ile Leu Leu Cys Gly Glu Pro Pro Phe Leu 
305                 310                 315                 320 


Ala Asn Ser Glu Glu Lys Leu Tyr Glu Leu Ile Lys Lys Gly Glu Leu 
                325                 330                 335     


Arg Phe Glu Asn Pro Val Trp Glu Ser Val Ser Asp Ser Ala Lys Asn 
            340                 345                 350         


Thr Leu Lys Gln Leu Met Lys Val Asp Pro Ala His Arg Ile Thr Ala 
        355                 360                 365             


Lys Glu Leu Leu Asp Asn Gln Trp Leu Thr Gly Asn Thr Leu Ser Ser 
    370                 375                 380                 


Ala Arg Pro Thr Asn Val Leu Glu Met Met Lys Glu Trp Lys Asn Asn 
385                 390                 395                 400 


Pro Glu Ser Asp Glu Glu Thr Asn Thr Asp Glu Glu Thr Glu Gln Ser 
                405                 410                 415     


Ala Val Tyr Ser Pro Ser Ala Asn Thr Ala Lys Gln Pro Thr Asn Ala 
            420                 425                 430         


Ala Lys Lys Pro Ala Ala Glu Ser Val Gly Met Thr Ser Ser Asn Ser 
        435                 440                 445             


Ser Ser Ser Lys Leu Leu Ser Ala Glu Ser Lys Ala Glu Pro Glu Lys 
    450                 455                 460                 


Ser Ser Glu Thr Val Gly His Ala Ser Val Ala Lys Thr Thr Leu Lys 
465                 470                 475                 480 


Ser Thr Thr Leu Phe Arg Gly Lys Lys Arg Leu 
                485                 490     


<210>  135
<211>  2961
<212>  DNA
<213>  Homo sapiens

<400>  135
atggctctgc ggaggctggg ggccgcgctg ctgctgctgc cgctgctcgc cgccgtggaa       60

gaaacgctaa tggactccac tacagcgact gctgagctgg gctggatggt gcatcctcca      120

tcagggtggg aagaggtgag tggctacgat gagaacatga acacgatccg cacgtaccag      180

gtgtgcaacg tgtttgagtc aagccagaac aactggctac ggaccaagtt tatccggcgc      240

cgtggcgccc accgcatcca cgtggagatg aagttttcgg tgcgtgactg cagcagcatc      300

cccagcgtgc ctggctcctg caaggagacc ttcaacctct attactatga ggctgacttt      360

gactcggcca ccaagacctt ccccaactgg atggagaatc catgggtgaa ggtggatacc      420

attgcagccg acgagagctt ctcccaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

accgaggtgc ggagcttcgg acctgtgtcc cgcagcggct tctacctggc cttccaggac      540

tatggcggct gcatgtccct catcgccgtg cgtgtcttct accgcaagtg cccccgcatc      600

atccagaatg gcgccatctt ccaggaaacc ctgtcggggg ctgagagcac atcgctggtg      660

gctgcccggg gcagctgcat cgccaatgcg gaagaggtgg atgtacccat caagctctac      720

tgtaacgggg acggcgagtg gctggtgccc atcgggcgct gcatgtgcaa agcaggcttc      780

gaggccgttg agaatggcac cgtctgccga ggttgtccat ctgggacttt caaggccaac      840

caaggggatg aggcctgtac ccactgtccc atcaacagcc ggaccacttc tgaaggggcc      900

accaactgtg tctgccgcaa tggctactac agagcagacc tggaccccct ggacatgccc      960

tgcacaacca tcccctccgc gccccaggct gtgatttcca gtgtcaatga gacctccctc     1020

atgctggagt ggacccctcc ccgcgactcc ggaggccgag aggacctcgt ctacaacatc     1080

atctgcaaga gctgtggctc gggccggggt gcctgcaccc gctgcgggga caatgtacag     1140

tacgcaccac gccagctagg cctgaccgag ccacgcattt acatcagtga cctgctggcc     1200

cacacccagt acaccttcga gatccaggct gtgaacggcg ttactgacca gagccccttc     1260

tcgcctcagt tcgcctctgt gaacatcacc accaaccagg cagctccatc ggcagtgtcc     1320

atcatgcatc aggtgagccg caccgtggac agcattaccc tgtcgtggtc ccagccggac     1380

cagcccaatg gcgtgatcct ggactatgag ctgcagtact atgagaagga gctcagtgag     1440

tacaacgcca cagccataaa aagccccacc aacacggtca ccgtgcaggg cctcaaagcc     1500

ggcgccatct atgtcttcca ggtgcgggca cgcaccgtgg caggctacgg gcgctacagc     1560

ggcaagatgt acttccagac catgacagaa gccgagtacc agacaagcat ccaggagaag     1620

ttgccactca tcatcggctc ctcggccgct ggcctggtct tcctcattgc tgtggttgtc     1680

atcgccatcg tgtgtaacag acgggggttt gagcgtgctg actcggagta cacggacaag     1740

ctgcaacact acaccagtgg ccacatgacc ccaggcatga agatctacat cgatcctttc     1800

acctacgagg accccaacga ggcagtgcgg gagtttgcca aggaaattga catctcctgt     1860

gtcaaaattg agcaggtgat cggagcaggg gagtttggcg aggtctgcag tggccacctg     1920

aagctgccag gcaagagaga gatctttgtg gccatcaaga cgctcaagtc gggctacacg     1980

gagaagcagc gccgggactt cctgagcgaa gcctccatca tgggccagtt cgaccatccc     2040

aacgtcatcc acctggaggg tgtcgtgacc aagagcacac ctgtgatgat catcaccgag     2100

ttcatggaga atggctccct ggactccttt ctccggcaaa acgatgggca gttcacagtc     2160

atccagctgg tgggcatgct tcggggcatc gcagctggca tgaagtacct ggcagacatg     2220

aactatgttc accgtgacct ggctgcccgc aacatcctcg tcaacagcaa cctggtctgc     2280

aaggtgtcgg actttgggct ctcacgcttt ctagaggacg atacctcaga ccccacctac     2340

accagtgccc tgggcggaaa gatccccatc cgctggacag ccccggaagc catccagtac     2400

cggaagttca cctcggccag tgatgtgtgg agctacggca ttgtcatgtg ggaggtgatg     2460

tcctatgggg agcggcccta ctgggacatg accaaccagg atgtaatcaa tgccattgag     2520

caggactatc ggctgccacc gcccatggac tgcccgagcg ccctgcacca actcatgctg     2580

gactgttggc agaaggaccg caaccaccgg cccaagttcg gccaaattgt caacacgcta     2640

gacaagatga tccgcaatcc caacagcctc aaagccatgg cgcccctctc ctctggcatc     2700

aacctgccgc tgctggaccg cacgatcccc gactacacca gctttaacac ggtggacgag     2760

tggctggagg ccatcaagat ggggcagtac aaggagagct tcgccaatgc cggcttcacc     2820

tcctttgacg tcgtgtctca gatgatgatg gaggacattc tccgggttgg ggtcactttg     2880

gctggccacc agaaaaaaat cctgaacagt atccaggtga tgcgggcgca gatgaaccag     2940

attcagtctg tggaggtttg a                                               2961


<210>  136
<211>  2964
<212>  DNA
<213>  Homo sapiens

<400>  136
atggctctgc ggaggctggg ggccgcgctg ctgctgctgc cgctgctcgc cgccgtggaa       60

gaaacgctaa tggactccac tacagcgact gctgagctgg gctggatggt gcatcctcca      120

tcagggtggg aagaggtgag tggctacgat gagaacatga acacgatccg cacgtaccag      180

gtgtgcaacg tgtttgagtc aagccagaac aactggctac ggaccaagtt tatccggcgc      240

cgtggcgccc accgcatcca cgtggagatg aagttttcgg tgcgtgactg cagcagcatc      300

cccagcgtgc ctggctcctg caaggagacc ttcaacctct attactatga ggctgacttt      360

gactcggcca ccaagacctt ccccaactgg atggagaatc catgggtgaa ggtggatacc      420

attgcagccg acgagagctt ctcccaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

accgaggtgc ggagcttcgg acctgtgtcc cgcagcggct tctacctggc cttccaggac      540

tatggcggct gcatgtccct catcgccgtg cgtgtcttct accgcaagtg cccccgcatc      600

atccagaatg gcgccatctt ccaggaaacc ctgtcggggg ctgagagcac atcgctggtg      660

gctgcccggg gcagctgcat cgccaatgcg gaagaggtgg atgtacccat caagctctac      720

tgtaacgggg acggcgagtg gctggtgccc atcgggcgct gcatgtgcaa agcaggcttc      780

gaggccgttg agaatggcac cgtctgccga ggttgtccat ctgggacttt caaggccaac      840

caaggggatg aggcctgtac ccactgtccc atcaacagcc ggaccacttc tgaaggggcc      900

accaactgtg tctgccgcaa tggctactac agagcagacc tggaccccct ggacatgccc      960

tgcacaacca tcccctccgc gccccaggct gtgatttcca gtgtcaatga gacctccctc     1020

atgctggagt ggacccctcc ccgcgactcc ggaggccgag aggacctcgt ctacaacatc     1080

atctgcaaga gctgtggctc gggccggggt gcctgcaccc gctgcgggga caatgtacag     1140

tacgcaccac gccagctagg cctgaccgag ccacgcattt acatcagtga cctgctggcc     1200

cacacccagt acaccttcga gatccaggct gtgaacggcg ttactgacca gagccccttc     1260

tcgcctcagt tcgcctctgt gaacatcacc accaaccagg cagctccatc ggcagtgtcc     1320

atcatgcatc aggtgagccg caccgtggac agcattaccc tgtcgtggtc ccagccggac     1380

cagcccaatg gcgtgatcct ggactatgag ctgcagtact atgagaagga gctcagtgag     1440

tacaacgcca cagccataaa aagccccacc aacacggtca ccgtgcaggg cctcaaagcc     1500

ggcgccatct atgtcttcca ggtgcgggca cgcaccgtgg caggctacgg gcgctacagc     1560

ggcaagatgt acttccagac catgacagaa gccgagtacc agacaagcat ccaggagaag     1620

ttgccactca tcatcggctc ctcggccgct ggcctggtct tcctcattgc tgtggttgtc     1680

atcgccatcg tgtgtaacag aagacggggg tttgagcgtg ctgactcgga gtacacggac     1740

aagctgcaac actacaccag tggccacatg accccaggca tgaagatcta catcgatcct     1800

ttcacctacg aggaccccaa cgaggcagtg cgggagtttg ccaaggaaat tgacatctcc     1860

tgtgtcaaaa ttgagcaggt gatcggagca ggggagtttg gcgaggtctg cagtggccac     1920

ctgaagctgc caggcaagag agagatcttt gtggccatca agacgctcaa gtcgggctac     1980

acggagaagc agcgccggga cttcctgagc gaagcctcca tcatgggcca gttcgaccat     2040

cccaacgtca tccacctgga gggtgtcgtg accaagagca cacctgtgat gatcatcacc     2100

gagttcatgg agaatggctc cctggactcc tttctccggc aaaacgatgg gcagttcaca     2160

gtcatccagc tggtgggcat gcttcggggc atcgcagctg gcatgaagta cctggcagac     2220

atgaactatg ttcaccgtga cctggctgcc cgcaacatcc tcgtcaacag caacctggtc     2280

tgcaaggtgt cggactttgg gctctcacgc tttctagagg acgatacctc agaccccacc     2340

tacaccagtg ccctgggcgg aaagatcccc atccgctgga cagccccgga agccatccag     2400

taccggaagt tcacctcggc cagtgatgtg tggagctacg gcattgtcat gtgggaggtg     2460

atgtcctatg gggagcggcc ctactgggac atgaccaacc aggatgtaat caatgccatt     2520

gagcaggact atcggctgcc accgcccatg gactgcccga gcgccctgca ccaactcatg     2580

ctggactgtt ggcagaagga ccgcaaccac cggcccaagt tcggccaaat tgtcaacacg     2640

ctagacaaga tgatccgcaa tcccaacagc ctcaaagcca tggcgcccct ctcctctggc     2700

atcaacctgc cgctgctgga ccgcacgatc cccgactaca ccagctttaa cacggtggac     2760

gagtggctgg aggccatcaa gatggggcag tacaaggaga gcttcgccaa tgccggcttc     2820

acctcctttg acgtcgtgtc tcagatgatg atggaggaca ttctccgggt tggggtcact     2880

ttggctggcc accagaaaaa aatcctgaac agtatccagg tgatgcgggc gcagatgaac     2940

cagattcagt ctgtggaggt ttga                                            2964


<210>  137
<211>  2787
<212>  DNA
<213>  Homo sapiens

<400>  137
atggctctgc ggaggctggg ggccgcgctg ctgctgctgc cgctgctcgc cgccgtggaa       60

gaaacgctaa tggactccac tacagcgact gctgagctgg gctggatggt gcatcctcca      120

tcagggtggg aagaggtgag tggctacgat gagaacatga acacgatccg cacgtaccag      180

gtgtgcaacg tgtttgagtc aagccagaac aactggctac ggaccaagtt tatccggcgc      240

cgtggcgccc accgcatcca cgtggagatg aagttttcgg tgcgtgactg cagcagcatc      300

cccagcgtgc ctggctcctg caaggagacc ttcaacctct attactatga ggctgacttt      360

gactcggcca ccaagacctt ccccaactgg atggagaatc catgggtgaa ggtggatacc      420

attgcagccg acgagagctt ctcccaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

accgaggtgc ggagcttcgg acctgtgtcc cgcagcggct tctacctggc cttccaggac      540

tatggcggct gcatgtccct catcgccgtg cgtgtcttct accgcaagtg cccccgcatc      600

atccagaatg gcgccatctt ccaggaaacc ctgtcggggg ctgagagcac atcgctggtg      660

gctgcccggg gcagctgcat cgccaatgcg gaagaggtgg atgtacccat caagctctac      720

tgtaacgggg acggcgagtg gctggtgccc atcgggcgct gcatgtgcaa agcaggcttc      780

gaggccgttg agaatggcac cgtctgccga ggttgtccat ctgggacttt caaggccaac      840

caaggggatg aggcctgtac ccactgtccc atcaacagcc ggaccacttc tgaaggggcc      900

accaactgtg tctgccgcaa tggctactac agagcagacc tggaccccct ggacatgccc      960

tgcacaacca tcccctccgc gccccaggct gtgatttcca gtgtcaatga gacctccctc     1020

atgctggagt ggacccctcc ccgcgactcc ggaggccgag aggacctcgt ctacaacatc     1080

atctgcaaga gctgtggctc gggccggggt gcctgcaccc gctgcgggga caatgtacag     1140

tacgcaccac gccagctagg cctgaccgag ccacgcattt acatcagtga cctgctggcc     1200

cacacccagt acaccttcga gatccaggct gtgaacggcg ttactgacca gagccccttc     1260

tcgcctcagt tcgcctctgt gaacatcacc accaaccagg cagctccatc ggcagtgtcc     1320

atcatgcatc aggtgagccg caccgtggac agcattaccc tgtcgtggtc ccagccggac     1380

cagcccaatg gcgtgatcct ggactatgag ctgcagtact atgagaagga gctcagtgag     1440

tacaacgcca cagccataaa aagccccacc aacacggtca ccgtgcaggg cctcaaagcc     1500

ggcgccatct atgtcttcca ggtgcgggca cgcaccgtgg caggctacgg gcgctacagc     1560

ggcaagatgt acttccagac catgacagaa gtgaccccag gcatgaagat ctacatcgat     1620

cctttcacct acgaggaccc caacgaggca gtgcgggagt ttgccaagga aattgacatc     1680

tcctgtgtca aaattgagca ggtgatcgga gcaggggagt ttggcgaggt ctgcagtggc     1740

cacctgaagc tgccaggcaa gagagagatc tttgtggcca tcaagacgct caagtcgggc     1800

tacacggaga agcagcgccg ggacttcctg agcgaagcct ccatcatggg ccagttcgac     1860

catcccaacg tcatccacct ggagggtgtc gtgaccaaga gcacacctgt gatgatcatc     1920

accgagttca tggagaatgg ctccctggac tcctttctcc ggcaaaacga tgggcagttc     1980

acagtcatcc agctggtggg catgcttcgg ggcatcgcag ctggcatgaa gtacctggca     2040

gacatgaact atgttcaccg tgacctggct gcccgcaaca tcctcgtcaa cagcaacctg     2100

gtctgcaagg tgtcggactt tgggctctca cgctttctag aggacgatac ctcagacccc     2160

acctacacca gtgccctggg cggaaagatc cccatccgct ggacagcccc ggaagccatc     2220

cagtaccgga agttcacctc ggccagtgat gtgtggagct acggcattgt catgtgggag     2280

gtgatgtcct atggggagcg gccctactgg gacatgacca accaggatgt aatcaatgcc     2340

attgagcagg actatcggct gccaccgccc atggactgcc cgagcgccct gcaccaactc     2400

atgctggact gttggcagaa ggaccgcaac caccggccca agttcggcca aattgtcaac     2460

acgctagaca agatgatccg caatcccaac agcctcaaag ccatggcgcc cctctcctct     2520

ggcatcaacc tgccgctgct ggaccgcacg atccccgact acaccagctt taacacggtg     2580

gacgagtggc tggaggccat caagatgggg cagtacaagg agagcttcgc caatgccggc     2640

ttcacctcct ttgacgtcgt gtctcagatg atgatggagg acattctccg ggttggggtc     2700

actttggctg gccaccagaa aaaaatcctg aacagtatcc aggtgatgcg ggcgcagatg     2760

aaccagattc agtctgtgga ggtttga                                         2787


<210>  138
<211>  3168
<212>  DNA
<213>  Homo sapiens

<400>  138
atggctctgc ggaggctggg ggccgcgctg ctgctgctgc cgctgctcgc cgccgtggaa       60

gaaacgctaa tggactccac tacagcgact gctgagctgg gctggatggt gcatcctcca      120

tcagggtggg aagaggtgag tggctacgat gagaacatga acacgatccg cacgtaccag      180

gtgtgcaacg tgtttgagtc aagccagaac aactggctac ggaccaagtt tatccggcgc      240

cgtggcgccc accgcatcca cgtggagatg aagttttcgg tgcgtgactg cagcagcatc      300

cccagcgtgc ctggctcctg caaggagacc ttcaacctct attactatga ggctgacttt      360

gactcggcca ccaagacctt ccccaactgg atggagaatc catgggtgaa ggtggatacc      420

attgcagccg acgagagctt ctcccaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

accgaggtgc ggagcttcgg acctgtgtcc cgcagcggct tctacctggc cttccaggac      540

tatggcggct gcatgtccct catcgccgtg cgtgtcttct accgcaagtg cccccgcatc      600

atccagaatg gcgccatctt ccaggaaacc ctgtcggggg ctgagagcac atcgctggtg      660

gctgcccggg gcagctgcat cgccaatgcg gaagaggtgg atgtacccat caagctctac      720

tgtaacgggg acggcgagtg gctggtgccc atcgggcgct gcatgtgcaa agcaggcttc      780

gaggccgttg agaatggcac cgtctgccga ggttgtccat ctgggacttt caaggccaac      840

caaggggatg aggcctgtac ccactgtccc atcaacagcc ggaccacttc tgaaggggcc      900

accaactgtg tctgccgcaa tggctactac agagcagacc tggaccccct ggacatgccc      960

tgcacaacca tcccctccgc gccccaggct gtgatttcca gtgtcaatga gacctccctc     1020

atgctggagt ggacccctcc ccgcgactcc ggaggccgag aggacctcgt ctacaacatc     1080

atctgcaaga gctgtggctc gggccggggt gcctgcaccc gctgcgggga caatgtacag     1140

tacgcaccac gccagctagg cctgaccgag ccacgcattt acatcagtga cctgctggcc     1200

cacacccagt acaccttcga gatccaggct gtgaacggcg ttactgacca gagccccttc     1260

tcgcctcagt tcgcctctgt gaacatcacc accaaccagg cagctccatc ggcagtgtcc     1320

atcatgcatc aggtgagccg caccgtggac agcattaccc tgtcgtggtc ccagccggac     1380

cagcccaatg gcgtgatcct ggactatgag ctgcagtact atgagaagga gctcagtgag     1440

tacaacgcca cagccataaa aagccccacc aacacggtca ccgtgcaggg cctcaaagcc     1500

ggcgccatct atgtcttcca ggtgcgggca cgcaccgtgg caggctacgg gcgctacagc     1560

ggcaagatgt acttccagac catgacagaa gccgagtacc agacaagcat ccaggagaag     1620

ttgccactca tcatcggctc ctcggccgct ggcctggtct tcctcattgc tgtggttgtc     1680

atcgccatcg tgtgtaacag acgggggttt gagcgtgctg actcggagta cacggacaag     1740

ctgcaacact acaccagtgg ccacatgacc ccaggcatga agatctacat cgatcctttc     1800

acctacgagg accccaacga ggcagtgcgg gagtttgcca aggaaattga catctcctgt     1860

gtcaaaattg agcaggtgat cggagcaggg gagtttggcg aggtctgcag tggccacctg     1920

aagctgccag gcaagagaga gatctttgtg gccatcaaga cgctcaagtc gggctacacg     1980

gagaagcagc gccgggactt cctgagcgaa gcctccatca tgggccagtt cgaccatccc     2040

aacgtcatcc acctggaggg tgtcgtgacc aagagcacac ctgtgatgat catcaccgag     2100

ttcatggaga atggctccct ggactccttt ctccggcaaa acgatgggca gttcacagtc     2160

atccagctgg tgggcatgct tcggggcatc gcagctggca tgaagtacct ggcagacatg     2220

aactatgttc accgtgacct ggctgcccgc aacatcctcg tcaacagcaa cctggtctgc     2280

aaggtgtcgg actttgggct ctcacgcttt ctagaggacg atacctcaga ccccacctac     2340

accagtgccc tgggcggaaa gatccccatc cgctggacag ccccggaagc catccagtac     2400

cggaagttca cctcggccag tgatgtgtgg agctacggca ttgtcatgtg ggaggtgatg     2460

tcctatgggg agcggcccta ctgggacatg accaaccagg atgtaatcaa tgccattgag     2520

caggactatc ggctgccacc gcccatggac tgcccgagcg ccctgcacca actcatgctg     2580

gactgttggc agaaggaccg caaccaccgg cccaagttcg gccaaattgt caacacgcta     2640

gacaagatga tccgcaatcc caacagcctc aaagccatgg cgcccctctc ctctggcatc     2700

aacctgccgc tgctggaccg cacgatcccc gactacacca gctttaacac ggtggacgag     2760

tggctggagg ccatcaagat ggggcagtac aaggagagct tcgccaatgc cggcttcacc     2820

tcctttgacg tcgtgtctca gatgatgatg gaggacattc tccgggttgg ggtcactttg     2880

gctggccacc agaaaaaaat cctgaacagt atccaggtga tgcgggcgca gatgaaccag     2940

attcagtctg tggagggcca gccactcgcc aggaggccac gggccacggg aagaaccaag     3000

cggtgccagc cacgagacgt caccaagaaa acatgcaact caaacgacgg aaaaaaaaag     3060

ggaatgggaa aaaagaaaac agatcctggg agggggcggg aaatacaagg aatatttttt     3120

aaagaggatt ctcataagga aagcaatgac tgttcttgcg ggggataa                  3168


<210>  139
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  140
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  141
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Val Thr Pro Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr 
    530                 535                 540                 


Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile 
545                 550                 555                 560 


Ser Cys Val Lys Ile Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu 
                565                 570                 575     


Val Cys Ser Gly His Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val 
            580                 585                 590         


Ala Ile Lys Thr Leu Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
        595                 600                 605             


Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Val 
    610                 615                 620                 


Ile His Leu Glu Gly Val Val Thr Lys Ser Thr Pro Val Met Ile Ile 
625                 630                 635                 640 


Thr Glu Phe Met Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn 
                645                 650                 655     


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
            660                 665                 670         


Ala Ala Gly Met Lys Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp 
        675                 680                 685             


Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val 
    690                 695                 700                 


Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro 
705                 710                 715                 720 


Thr Tyr Thr Ser Ala Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala 
                725                 730                 735     


Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp 
            740                 745                 750         


Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro 
        755                 760                 765             


Tyr Trp Asp Met Thr Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp 
    770                 775                 780                 


Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu 
785                 790                 795                 800 


Met Leu Asp Cys Trp Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly 
                805                 810                 815     


Gln Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu 
            820                 825                 830         


Lys Ala Met Ala Pro Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp 
        835                 840                 845             


Arg Thr Ile Pro Asp Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu 
    850                 855                 860                 


Glu Ala Ile Lys Met Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly 
865                 870                 875                 880 


Phe Thr Ser Phe Asp Val Val Ser Gln Met Met Met Glu Asp Ile Leu 
                885                 890                 895     


Arg Val Gly Val Thr Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser 
            900                 905                 910         


Ile Gln Val Met Arg Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
        915                 920                 925             


<210>  142
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Gly Gln Pro Leu Ala Arg Arg 
            980                 985                 990         


Pro Arg Ala Thr Gly Arg Thr Lys  Arg Cys Gln Pro Arg  Asp Val Thr 
        995                 1000                 1005             


Lys Lys  Thr Cys Asn Ser Asn  Asp Gly Lys Lys Lys  Gly Met Gly 
    1010                 1015                 1020             


Lys Lys  Lys Thr Asp Pro Gly  Arg Gly Arg Glu Ile  Gln Gly Ile 
    1025                 1030                 1035             


Phe Phe  Lys Glu Asp Ser His  Lys Glu Ser Asn Asp  Cys Ser Cys 
    1040                 1045                 1050             


Gly Gly  
    1055 


<210>  143
<211>  2964
<212>  DNA
<213>  Mus musculus

<400>  143
atggccgtgc gcaggctggg ggccgcgctg ctgctgctgc cgctgctagc cgccgtggaa       60

gaaaccctga tggactctac gacagcaacg gctgagctgg gctggatggt acatccccca      120

tcagggtggg aagaggtgag cggctacgac gagaacatga acactatccg tacctaccag      180

gtgtgcaatg tctttgagtc aagccagaac aactggctgc ggaccaaatt catccggcgc      240

cgcggcgccc accgcatcca cgtggagatg aagttctcgg tgcgtgactg cagcagcatt      300

cccagcgtgc cgggctcctg caaggagacc ttcaacctct actactatga ggctgatttt      360

gacttagcca ccaaaacctt tcccaactgg atggagaatc cgtgggtgaa ggtggacacc      420

atcgcggccg atgagagctt ctctcaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

actgaggtgc gaagcttcgg tcccgtgtcc cgcaatggtt tctacctggc cttccaggac      540

tatggcggct gtatgtccct cattgctgtg cgcgtcttct accggaagtg cccccgaatc      600

atccagaatg gtgccatctt ccaggagaca ctgtcggggg ctgagagcac ttcgctggtg      660

gcagctcggg gcagctgcat cgccaatgct gaagaagtgg atgtgcccat caaactctac      720

tgtaacgggg acggcgaatg gctggtgccc ataggtcgct gcatgtgcaa ggcgggcttc      780

gaggctgtgg agaacggcac cgtctgccga ggttgtccat caggaacctt caaggccaac      840

caaggggacg aagcctgcac ccactgtccc atcaacagcc gcaccacctc cgagggtgcc      900

accaactgtg tatgccgcaa cggctactac agggccgacc tggacccctt agacatgcct      960

tgcacaacca tcccctctgc gccccaggct gtgatctcca gcgtcaacga gacgtccctc     1020

atgctagagt ggaccccacc ccgagactcg gggggtcgcg aggatcttgt ttacaacatc     1080

atctgcaaga gctgtggctc cggccggggc gcatgcacgc gctgcgggga caacgtgcag     1140

tacgcgcccc gccagctggg cctgactgag ccgcgcatct acatcagtga cctgctggca     1200

cacacgcagt acaccttcga gatccaggcc gtgaacggtg tgactgacca gagtcccttc     1260

tcacctcagt tcgcctctgt gaacatcacc accaaccaag cagcaccatc ggccgtgtcc     1320

atcatgcacc aggtgagccg cactgtggac agcatcaccc tgtcgtggtc ccagccagac     1380

cagcccaacg gtgtgatcct ggactacgag ctgcagtact atgagaagca ggagctcagt     1440

gagtacaacg ccacggccat aaaaagcccc accaacacag tcactgtgca gggcctcaaa     1500

gccggcgcca tctatgtctt ccaggtgcgg gcacgcaccg ttgcaggcta tgggcgctac     1560

agtggcaaga tgtacttcca aaccatgaca gaagccgagt accagaccag catcaaggaa     1620

aagctacccc tcatcgttgg ctcctccgcc gccggcttag tcttcctcat cgctgtggtc     1680

gtcattgcca tcgtatgtaa cagacggggg tttgagcgtg ccgactcaga gtacacggac     1740

aagctacaac actacaccag cggacacatg accccaggca tgaagatcta tatagaccct     1800

ttcacctatg aagatcctaa tgaggcagtg cgggagtttg ccaaggaaat tgacatctcc     1860

tgtgtcaaga ttgagcaggt gatcggagca ggggaatttg gtgaggtctg cagtggccat     1920

ttgaagctgc caggcaagag agagatcttt gtagccatca agaccctcaa gtcaggatac     1980

acggagaaac agcgccggga cttcctgagt gaggcatcca tcatgggcca gttcgaccac     2040

cccaatgtca tccatctgga aggggttgtc accaagagca cacctgtcat gatcatcact     2100

gaattcatgg agaacggatc tctggactcc ttcctccggc aaaacgatgg gcagttcaca     2160

gtcatccaac tggtgggcat gctgaggggc attgcagccg gcatgaagta cctggcggac     2220

atgaactacg tgcaccgtga ccttgctgct cgaaacatcc tcgtcaacag caacctggtg     2280

tgtaaggtgt ctgattttgg gctctcacgc ttcctggagg atgacacgtc tgaccccacc     2340

tataccagcg ctctgggtgg gaagatcccc atccgttgga cggcaccgga agccatccag     2400

taccggaaat tcacctcggc cagtgatgtg tggagctatg gcatcgtcat gtgggaggtg     2460

atgtcctacg gggaacgacc ctactgggac atgaccaatc aagacgtaat caacgccatt     2520

gaacaggact acagactacc tccgcccatg gactgcccta gtgccctgca ccagctcatg     2580

ctggactgct ggcagaagga ccgcaaccac cggcccaagt tcggccagat tgtcaacacg     2640

ctggacaaga tgatccgaaa ccccaacagc ctcaaagcca tggcacccct gtcctctggc     2700

atcaacctgc cactgctgga ccgcacgata ccggactaca ccagctttaa cacggtggat     2760

gagtggctag aggccatcaa gatgggccag tacaaggaga gctttgccaa cgccggcttt     2820

acctctttcg acgttgtatc tcagatgatg atggaggaca ttctccgcgt tggggtcact     2880

ctagctggcc accagaaaaa aatcctgaac agtatccagg tgatgcgggc ccagatgaac     2940

cagatccagt ctgtagaggt ttga                                            2964


<210>  144
<211>  2961
<212>  DNA
<213>  Mus musculus

<400>  144
atggccgtgc gcaggctggg ggccgcgctg ctgctgctgc cgctgctagc cgccgtggaa       60

gaaaccctga tggactctac gacagcaacg gctgagctgg gctggatggt acatccccca      120

tcagggtggg aagaggtgag cggctacgac gagaacatga acactatccg tacctaccag      180

gtgtgcaatg tctttgagtc aagccagaac aactggctgc ggaccaaatt catccggcgc      240

cgcggcgccc accgcatcca cgtggagatg aagttctcgg tgcgtgactg cagcagcatt      300

cccagcgtgc cgggctcctg caaggagacc ttcaacctct actactatga ggctgatttt      360

gacttagcca ccaaaacctt tcccaactgg atggagaatc cgtgggtgaa ggtggacacc      420

atcgcggccg atgagagctt ctctcaggtg gacctgggtg gccgcgtcat gaaaatcaac      480

actgaggtgc gaagcttcgg tcccgtgtcc cgcaatggtt tctacctggc cttccaggac      540

tatggcggct gtatgtccct cattgctgtg cgcgtcttct accggaagtg cccccgaatc      600

atccagaatg gtgccatctt ccaggagaca ctgtcggggg ctgagagcac ttcgctggtg      660

gcagctcggg gcagctgcat cgccaatgct gaagaagtgg atgtgcccat caaactctac      720

tgtaacgggg acggcgaatg gctggtgccc ataggtcgct gcatgtgcaa ggcgggcttc      780

gaggctgtgg agaacggcac cgtctgccga ggttgtccat caggaacctt caaggccaac      840

caaggggacg aagcctgcac ccactgtccc atcaacagcc gcaccacctc cgagggtgcc      900

accaactgtg tatgccgcaa cggctactac agggccgacc tggacccctt agacatgcct      960

tgcacaacca tcccctctgc gccccaggct gtgatctcca gcgtcaacga gacgtccctc     1020

atgctagagt ggaccccacc ccgagactcg gggggtcgcg aggatcttgt ttacaacatc     1080

atctgcaaga gctgtggctc cggccggggc gcatgcacgc gctgcgggga caacgtgcag     1140

tacgcgcccc gccagctggg cctgactgag ccgcgcatct acatcagtga cctgctggca     1200

cacacgcagt acaccttcga gatccaggcc gtgaacggtg tgactgacca gagtcccttc     1260

tcacctcagt tcgcctctgt gaacatcacc accaaccaag cagcaccatc ggccgtgtcc     1320

atcatgcacc aggtgagccg cactgtggac agcatcaccc tgtcgtggtc ccagccagac     1380

cagcccaacg gtgtgatcct ggactacgag ctgcagtact atgagaagga gctcagtgag     1440

tacaacgcca cggccataaa aagccccacc aacacagtca ctgtgcaggg cctcaaagcc     1500

ggcgccatct atgtcttcca ggtgcgggca cgcaccgttg caggctatgg gcgctacagt     1560

ggcaagatgt acttccaaac catgacagaa gccgagtacc agaccagcat caaggaaaag     1620

ctacccctca tcgttggctc ctccgccgcc ggcttagtct tcctcatcgc tgtggtcgtc     1680

attgccatcg tatgtaacag acgggggttt gagcgtgccg actcagagta cacggacaag     1740

ctacaacact acaccagcgg acacatgacc ccaggcatga agatctatat agaccctttc     1800

acctatgaag atcctaatga ggcagtgcgg gagtttgcca aggaaattga catctcctgt     1860

gtcaagattg agcaggtgat cggagcaggg gaatttggtg aggtctgcag tggccatttg     1920

aagctgccag gcaagagaga gatctttgta gccatcaaga ccctcaagtc aggatacacg     1980

gagaaacagc gccgggactt cctgagtgag gcatccatca tgggccagtt cgaccacccc     2040

aatgtcatcc atctggaagg ggttgtcacc aagagcacac ctgtcatgat catcactgaa     2100

ttcatggaga acggatctct ggactccttc ctccggcaaa acgatgggca gttcacagtc     2160

atccaactgg tgggcatgct gaggggcatt gcagccggca tgaagtacct ggcggacatg     2220

aactacgtgc accgtgacct tgctgctcga aacatcctcg tcaacagcaa cctggtgtgt     2280

aaggtgtctg attttgggct ctcacgcttc ctggaggatg acacgtctga ccccacctat     2340

accagcgctc tgggtgggaa gatccccatc cgttggacgg caccggaagc catccagtac     2400

cggaaattca cctcggccag tgatgtgtgg agctatggca tcgtcatgtg ggaggtgatg     2460

tcctacgggg aacgacccta ctgggacatg accaatcaag acgtaatcaa cgccattgaa     2520

caggactaca gactacctcc gcccatggac tgccctagtg ccctgcacca gctcatgctg     2580

gactgctggc agaaggaccg caaccaccgg cccaagttcg gccagattgt caacacgctg     2640

gacaagatga tccgaaaccc caacagcctc aaagccatgg cacccctgtc ctctggcatc     2700

aacctgccac tgctggaccg cacgataccg gactacacca gctttaacac ggtggatgag     2760

tggctagagg ccatcaagat gggccagtac aaggagagct ttgccaacgc cggctttacc     2820

tctttcgacg ttgtatctca gatgatgatg gaggacattc tccgcgttgg ggtcactcta     2880

gctggccacc agaaaaaaat cctgaacagt atccaggtga tgcgggccca gatgaaccag     2940

atccagtctg tagaggtttg a                                               2961


<210>  145
<211>  987
<212>  PRT
<213>  Mus musculus

<400>  145

Met Ala Val Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Leu Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Asn Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Gln Glu Leu Ser 
465                 470                 475                 480 


Glu Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val 
                485                 490                 495     


Gln Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg 
            500                 505                 510         


Thr Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr 
        515                 520                 525             


Met Thr Glu Ala Glu Tyr Gln Thr Ser Ile Lys Glu Lys Leu Pro Leu 
    530                 535                 540                 


Ile Val Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val 
545                 550                 555                 560 


Val Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  146
<211>  986
<212>  PRT
<213>  Mus musculus

<400>  146

Met Ala Val Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Leu Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Asn Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Lys Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Val Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  147
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  147
atggtttctg ccaagaaggt acccgcgatc gctctgtccg ccggggtcag tttcgccctc       60

ctgcgcttcc tgtgcctggc ggtttgttta aacgaatccc caggacagaa ccaaaaggag      120

gagaaattgt gcacagaaaa tttcacccgc atcctggaca gtttgctcga tggttatgac      180

aacaggctgc gtcctggatt tgggggtcct gttacagaag tgaaaactga catatatgtc      240

accagctttg gacctgtttc tgatgttgaa atggaataca caatggatgt gttcttcagg      300

cagacatgga ttgacaaaag attaaaatat gacggcccca ttgaaatttt gagattgaac      360

aatatgatgg taacgaaagt gtggacccct gatactttct tcaggaatgg aaagaaatct      420

gtctcacata atatgacagc tccaaataag ctttttagaa ttatgagaaa tggtactatt      480

ttatacacaa tgagactcac cataagtgcg gagtgtccca tgagattggt ggattttccc      540

atggatggtc atgcatgccc tttgaaattc gggagttatg cctatccaaa gagtgagatg      600

atctatacct ggacaaaagg tcctgagaaa tcagttgaag ttccgaagga gtcttccagc      660

ttagttcaat atgatttgat tgggcaaacc gtatcaagtg aaaccatcaa atcaattacg      720

ggtgaatata ttgttatgac ggtttacttc cacctcagac ggaagatggg ttattttatg      780

attcagacct atattccgtg cattatgaca gtgattcttt ctcaagtttc attttggata      840

aataaagaat cagttcccgc taggactgta tttggaataa caactgtcct caccatgacc      900

acactaagca tcagtgcacg acattctttg cccaaagtgt cctatgctac cgccatggac      960

tggttcatag ctgtctgctt tgcttttgta ttttcggccc ttatcgagtt tgctgctgtc     1020

aactatttca ccaatattca aatggaaaaa gccaaaagga agacatcaaa gccccctcag     1080

gaagttcccg ctgctccagt gcagagagag aagcatcctg aagcccctct gcagaataca     1140

aatgccaatt tgaacatgag aaaaagaaca aatgctttgg ttcactctga atctgatgtt     1200

ggcaacagaa ctgaggtggg aaaccattca agcaaatctt ccacagttgt tcaagaatct     1260

tctaaaggca cacctcggtc ttacttagct tccagtccaa acccattcag ccgtgcaaat     1320

gcagctgaaa ccatatctgc agcaagagca cttccatctg cttctcctac ttctatccga     1380

actggatata tgcctcgaaa ggcttcagtt ggatctgctt ctactcgtca cgtgtttgga     1440

tcaagactgc agaggataaa gaccacagtt aataccatag gggctactgg gaagttgtca     1500

gctactcctc ctccatcggc tccaccacct tctggatctg gcacaagtaa aatagacaaa     1560

tatgcccgta ttctctttcc agtcacattt ggggcattta acatggttta ttgggttgtt     1620

tatttatcta aggacactat ggagaaatca gaaagtctaa tgtaa                     1665


<210>  148
<211>  1608
<212>  DNA
<213>  Homo sapiens

<400>  148
atgttgcaaa gatggtttct gccaagaagt ttaaacgaat ccccaggaca gaaccaaaag       60

gaggagaaat tgtgcacaga aaatttcacc cgcatcctgg acagtttgct cgatggttat      120

gacaacaggc tgcgtcctgg atttgggggt cctgttacag aagtgaaaac tgacatatat      180

gtcaccagct ttggacctgt ttctgatgtt gaaatggaat acacaatgga tgtgttcttc      240

aggcagacat ggattgacaa aagattaaaa tatgacggcc ccattgaaat tttgagattg      300

aacaatatga tggtaacgaa agtgtggacc cctgatactt tcttcaggaa tggaaagaaa      360

tctgtctcac ataatatgac agctccaaat aagcttttta gaattatgag aaatggtact      420

attttataca caatgagact caccataagt gcggagtgtc ccatgagatt ggtggatttt      480

cccatggatg gtcatgcatg ccctttgaaa ttcgggagtt atgcctatcc aaagagtgag      540

atgatctata cctggacaaa aggtcctgag aaatcagttg aagttccgaa ggagtcttcc      600

agcttagttc aatatgattt gattgggcaa accgtatcaa gtgaaaccat caaatcaatt      660

acgggtgaat atattgttat gacggtttac ttccacctca gacggaagat gggttatttt      720

atgattcaga cctatattcc gtgcattatg acagtgattc tttctcaagt ttcattttgg      780

ataaataaag aatcagttcc cgctaggact gtatttggaa taacaactgt cctcaccatg      840

accacactaa gcatcagtgc acgacattct ttgcccaaag tgtcctatgc taccgccatg      900

gactggttca tagctgtctg ctttgctttt gtattttcgg cccttatcga gtttgctgct      960

gtcaactatt tcaccaatat tcaaatggaa aaagccaaaa ggaagacatc aaagccccct     1020

caggaagttc ccgctgctcc agtgcagaga gagaagcatc ctgaagcccc tctgcagaat     1080

acaaatgcca atttgaacat gagaaaaaga acaaatgctt tggttcactc tgaatctgat     1140

gttggcaaca gaactgaggt gggaaaccat tcaagcaaat cttccacagt tgttcaagaa     1200

tcttctaaag gcacacctcg gtcttactta gcttccagtc caaacccatt cagccgtgca     1260

aatgcagctg aaaccatatc tgcagcaaga gcacttccat ctgcttctcc tacttctatc     1320

cgaactggat atatgcctcg aaaggcttca gttggatctg cttctactcg tcacgtgttt     1380

ggatcaagac tgcagaggat aaagaccaca gttaatacca taggggctac tgggaagttg     1440

tcagctactc ctcctccatc ggctccacca ccttctggat ctggcacaag taaaatagac     1500

aaatatgccc gtattctctt tccagtcaca tttggggcat ttaacatggt ttattgggtt     1560

gtttatttat ctaaggacac tatggagaaa tcagaaagtc taatgtaa                  1608


<210>  149
<211>  1455
<212>  DNA
<213>  Homo sapiens

<400>  149
atgttgcaaa gatggtttct gccaagaagt ttaaacgaat ccccaggaca gaaccaaaag       60

gaggagaaat tgtgcacaga aaatttcacc cgcatcctgg acagtttgct cgatggttat      120

gacaacaggc tgcgtcctgg atttgggggt cctgttacag aagtgaaaac tgacatatat      180

gtcaccagct ttggacctgt ttctgatgtt gaaatggaat acacaatgga tgtgttcttc      240

aggcagacat ggattgacaa aagattaaaa tatgacggcc ccattgaaat tttgagattg      300

aacaatatga tggtaacgaa agtgtggacc cctgatactt tcttcaggaa tggaaagaaa      360

tctgtctcac ataatatgac agctccaaat aagcttttta gaattatgag aaatggtact      420

attttataca caatgagact caccataagt gcggagtgtc ccatgagatt ggtggatttt      480

cccatggatg gtcatgcatg ccctttgaaa ttcgggagtt atgcctatcc aaagagtgag      540

atgatctata cctggacaaa aggtcctgag aaatcagttg aagttccgaa ggagtcttcc      600

agcttagttc aatatgattt gattgggcaa accgtatcaa gtgaaaccat caaatcaatt      660

acgggaataa caactgtcct caccatgacc acactaagca tcagtgcacg acattctttg      720

cccaaagtgt cctatgctac cgccatggac tggttcatag ctgtctgctt tgcttttgta      780

ttttcggccc ttatcgagtt tgctgctgtc aactatttca ccaatattca aatggaaaaa      840

gccaaaagga agacatcaaa gccccctcag gaagttcccg ctgctccagt gcagagagag      900

aagcatcctg aagcccctct gcagaataca aatgccaatt tgaacatgag aaaaagaaca      960

aatgctttgg ttcactctga atctgatgtt ggcaacagaa ctgaggtggg aaaccattca     1020

agcaaatctt ccacagttgt tcaagaatct tctaaaggca cacctcggtc ttacttagct     1080

tccagtccaa acccattcag ccgtgcaaat gcagctgaaa ccatatctgc agcaagagca     1140

cttccatctg cttctcctac ttctatccga actggatata tgcctcgaaa ggcttcagtt     1200

ggatctgctt ctactcgtca cgtgtttgga tcaagactgc agaggataaa gaccacagtt     1260

aataccatag gggctactgg gaagttgtca gctactcctc ctccatcggc tccaccacct     1320

tctggatctg gcacaagtaa aatagacaaa tatgcccgta ttctctttcc agtcacattt     1380

ggggcattta acatggttta ttgggttgtt tatttatcta aggacactat ggagaaatca     1440

gaaagtctaa tgtaa                                                      1455


<210>  150
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  151
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Leu Gln Arg Trp Phe Leu Pro Arg Ser Leu Asn Glu Ser Pro Gly 
1               5                   10                  15      


Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe Thr Arg Ile 
            20                  25                  30          


Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Phe 
        35                  40                  45              


Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val Thr Ser Phe 
    50                  55                  60                  


Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp Val Phe Phe 
65                  70                  75                  80  


Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly Pro Ile Glu 
                85                  90                  95      


Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp Thr Pro Asp 
            100                 105                 110         


Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn Met Thr Ala 
        115                 120                 125             


Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile Leu Tyr Thr 
    130                 135                 140                 


Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu Val Asp Phe 
145                 150                 155                 160 


Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr 
                165                 170                 175     


Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro Glu Lys Ser 
            180                 185                 190         


Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr Asp Leu Ile 
        195                 200                 205             


Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr Gly Glu Tyr 
    210                 215                 220                 


Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met Gly Tyr Phe 
225                 230                 235                 240 


Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile Leu Ser Gln 
                245                 250                 255     


Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg Thr Val Phe 
            260                 265                 270         


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg 
        275                 280                 285             


His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp Trp Phe Ile 
    290                 295                 300                 


Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Ala 
305                 310                 315                 320 


Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys Arg Lys Thr 
                325                 330                 335     


Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln Arg Glu Lys 
            340                 345                 350         


His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu Asn Met Arg 
        355                 360                 365             


Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val Gly Asn Arg 
    370                 375                 380                 


Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val Val Gln Glu 
385                 390                 395                 400 


Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser Pro Asn Pro 
                405                 410                 415     


Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala Arg Ala Leu 
            420                 425                 430         


Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met Pro Arg Lys 
        435                 440                 445             


Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly Ser Arg Leu 
    450                 455                 460                 


Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr Gly Lys Leu 
465                 470                 475                 480 


Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly Ser Gly Thr 
                485                 490                 495     


Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val Thr Phe Gly 
            500                 505                 510         


Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met 
        515                 520                 525             


Glu Lys Ser Glu Ser Leu Met 
    530                 535 


<210>  152
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Leu Gln Arg Trp Phe Leu Pro Arg Ser Leu Asn Glu Ser Pro Gly 
1               5                   10                  15      


Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe Thr Arg Ile 
            20                  25                  30          


Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Phe 
        35                  40                  45              


Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val Thr Ser Phe 
    50                  55                  60                  


Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp Val Phe Phe 
65                  70                  75                  80  


Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly Pro Ile Glu 
                85                  90                  95      


Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp Thr Pro Asp 
            100                 105                 110         


Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn Met Thr Ala 
        115                 120                 125             


Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile Leu Tyr Thr 
    130                 135                 140                 


Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu Val Asp Phe 
145                 150                 155                 160 


Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr 
                165                 170                 175     


Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro Glu Lys Ser 
            180                 185                 190         


Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr Asp Leu Ile 
        195                 200                 205             


Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr Gly Ile Thr 
    210                 215                 220                 


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg His Ser Leu 
225                 230                 235                 240 


Pro Lys Val Ser Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
                245                 250                 255     


Phe Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Ala Val Asn Tyr 
            260                 265                 270         


Phe Thr Asn Ile Gln Met Glu Lys Ala Lys Arg Lys Thr Ser Lys Pro 
        275                 280                 285             


Pro Gln Glu Val Pro Ala Ala Pro Val Gln Arg Glu Lys His Pro Glu 
    290                 295                 300                 


Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu Asn Met Arg Lys Arg Thr 
305                 310                 315                 320 


Asn Ala Leu Val His Ser Glu Ser Asp Val Gly Asn Arg Thr Glu Val 
                325                 330                 335     


Gly Asn His Ser Ser Lys Ser Ser Thr Val Val Gln Glu Ser Ser Lys 
            340                 345                 350         


Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser Pro Asn Pro Phe Ser Arg 
        355                 360                 365             


Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala Arg Ala Leu Pro Ser Ala 
    370                 375                 380                 


Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met Pro Arg Lys Ala Ser Val 
385                 390                 395                 400 


Gly Ser Ala Ser Thr Arg His Val Phe Gly Ser Arg Leu Gln Arg Ile 
                405                 410                 415     


Lys Thr Thr Val Asn Thr Ile Gly Ala Thr Gly Lys Leu Ser Ala Thr 
            420                 425                 430         


Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly Ser Gly Thr Ser Lys Ile 
        435                 440                 445             


Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val Thr Phe Gly Ala Phe Asn 
    450                 455                 460                 


Met Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met Glu Lys Ser 
465                 470                 475                 480 


Glu Ser Leu Met 
                


<210>  153
<211>  1659
<212>  DNA
<213>  Mus musculus

<400>  153
atggtttctg tccagaaggt acccgcgatt gcgctgtgct ccggggtcag cctcgccctc       60

ctgcacttcc tgtgcctggc ggcttgttta aacgaatccc caggacagaa ctcaaaggac      120

gagaaattgt gcccggaaaa ttttacccgt attctggaca gtttgctgga tggttatgac      180

aacaggctgc gtcctggatt tgggggtcct gttacagaag tgaaaactga tatatatgtc      240

accagctttg ggcccgtttc tgatgttgaa atggaataca ctatggatgt gttcttcaga      300

cagacatgga ttgacaaaag actaaaatat gacggcccaa ttgaaatctt gaggctgaat      360

aatatgatgg tcaccaaagt ttggacccct gatactttct tcaggaatgg aaagaaatct      420

gtctcacata acatgacagc tccaaataag ctttttagaa ttatgagaaa tggcactatt      480

ttatacacaa tgagactcac cataagtgcg gagtgcccca tgagactggt ggattttcct      540

atggatggtc atgcctgccc tttgaaattt gggagttatg catatcccaa aagtgagatg      600

atctacacct ggaccaaagg ccctgagaag tcagtggagg tgccaaagga gtcttctagc      660

ttagttcaat atgacctcat tgggcagact gtatcaagcg agactatcaa atctattaca      720

ggtgaataca ttgttatgac ggtttacttc cacctcagac ggaagatggg ctactttatg      780

attcagacgt atatcccatg catcatgaca gtgattcttt ctcaagtttc cttctggata      840

aacaaggagt ctgttccagc tagaactgta tttggaataa ccacagtcct cacgatgacc      900

accctaagca tcagtgctcg gcattctttg cccaaagtgt cctatgcgac tgccatggat      960

tggttcatag ctgtctgttt tgcttttgta ttttcggctc ttattgagtt tgctgctgtc     1020

aactatttca ccaacattca aatgcagaaa gccaaaaaga agatatcaaa gcctccccca     1080

gaagttccag ctgctcctgt gctgaaggag aaacacacag aaacatccct tcagaataca     1140

catgccaatt tgaacatgag gaaaagaaca aatgccttgg tccattcaga atcggatgtc     1200

aaaagcagaa ctgaggtggg aaatcactcc agcaagacca gcgctgtcca ggagtcttct     1260

gaagccacgc ctaaggctca cttagcttcc agtccaaatc cattcagcag ggcaaatgca     1320

gctgagacta tgtctgctgc agccagaggt ctttcatctg cagcatcccc ctctcctcat     1380

ggcacattgc ggccagcttc tttggggtca gcttccactc gccctgcatt tggatctaga     1440

cttgggcgaa ttaagacaac agttaataca acaggggctg ctgggaatgt gtcagccaca     1500

cctcctcccc ctgctccacc gccttctgga tctggcacaa gtaaaataga caaatatgct     1560

cgtattctct ttccagtcac atttggagca tttaacatgg tctactgggt tgtttattta     1620

tctaaggaca ccatggagaa atcagaaagt ctaatgtaa                            1659


<210>  154
<211>  552
<212>  PRT
<213>  Mus musculus

<400>  154

Met Val Ser Val Gln Lys Val Pro Ala Ile Ala Leu Cys Ser Gly Val 
1               5                   10                  15      


Ser Leu Ala Leu Leu His Phe Leu Cys Leu Ala Ala Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Ser Lys Asp Glu Lys Leu Cys Pro Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Gln Lys Ala Lys 
            340                 345                 350         


Lys Lys Ile Ser Lys Pro Pro Pro Glu Val Pro Ala Ala Pro Val Leu 
        355                 360                 365             


Lys Glu Lys His Thr Glu Thr Ser Leu Gln Asn Thr His Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Lys Ser Arg Thr Glu Val Gly Asn His Ser Ser Lys Thr Ser Ala Val 
                405                 410                 415     


Gln Glu Ser Ser Glu Ala Thr Pro Lys Ala His Leu Ala Ser Ser Pro 
            420                 425                 430         


Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Met Ser Ala Ala Ala 
        435                 440                 445             


Arg Gly Leu Ser Ser Ala Ala Ser Pro Ser Pro His Gly Thr Leu Arg 
    450                 455                 460                 


Pro Ala Ser Leu Gly Ser Ala Ser Thr Arg Pro Ala Phe Gly Ser Arg 
465                 470                 475                 480 


Leu Gly Arg Ile Lys Thr Thr Val Asn Thr Thr Gly Ala Ala Gly Asn 
                485                 490                 495     


Val Ser Ala Thr Pro Pro Pro Pro Ala Pro Pro Pro Ser Gly Ser Gly 
            500                 505                 510         


Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val Thr Phe 
        515                 520                 525             


Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr 
    530                 535                 540                 


Met Glu Lys Ser Glu Ser Leu Met 
545                 550         


<210>  155
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  155
atggacgaga cgagcccact agtgtccccc gagcgggccc aacccccgga ctacaccttc       60

ccgtcgggct cgggcgctca ctttccgcag gtgcccgggg gcgcggtccg agtggcggcg      120

gcggccggct cgggcccctc tccgccgggc tcgccgggcc acgaccgcga gcggcagcca      180

ctgttggatc gggcccgggg cgcggcggcc cagggccaga cccaaaccgt ggcggcgcag      240

gcccaggctc tggccgctca ggccgcggcg gcagcccacg ccgctcaggc ccaccgcgag      300

cggaacgagt tcccggagga tcctgagttc gaggcggtgg tgcggcaggc cgagctggcc      360

atcgagcgct gcatctttcc cgagcgcatc taccagggct ccagcggaag ctacttcgtc      420

aaggaccctc aggggaggat cattgctgtc ttcaaaccca agaatgaaga gccctatggg      480

catcttaatc ctaagtggac caagtggctg cagaagctgt gctgtccttg ctgctttggc      540

cgtgactgcc ttgtccttaa ccagggctat ctctcagaag caggggccag cctggtggac      600

caaaaactgg aactcaacat tgttccccgt acaaaggtag tatacctggc cagtgagacc      660

ttcaactata gtgccattga ccgagtgaag tccaggggca agcggcttgc actagagaaa      720

gtgccaaaag ttggacagcg gtttaaccgc atcgggctac caccaaaggt tggttcattc      780

cagctctttg ttgaaggcta caaagatgca gactattggc tgcggcgttt tgaagcagaa      840

cctcttcctg agaacactaa ccggcaacta ctgctccagt ttgagcggtt ggtggtgctg      900

gattacatca tccgcaacac tgatcgaggc aatgacaact ggctgattaa atatgactgt      960

ccaatggata gttctagctc tcgggacaca gactgggtgg tggtgaagga gcctgttatc     1020

aaggtggctg ccatagacaa tgggctggcc ttcccactga agcatcctga ctcctggagg     1080

gcatatcctt tttactgggc ctggttgccc caggcgaaag tcccattttc tcaggagatc     1140

aaagatctga tccttccaaa gatatcggac cctaacttcg tcaaggactt ggaagaggac     1200

ctatatgaac tcttcaagaa agatcctggt ttcgacaggg gccagttcca taagcagatt     1260

gctgtcatgc ggggccagat cttaaatctg acccaggcct tgaaagacaa caagagtccc     1320

ctgcacctcg tccagatgcc acctgtgatt gtcgagacgg cccgttccca ccagcggtct     1380

tctagcgagt cctacacaca gagctttcag agccggaagc ccttcttttc atggtggtag     1440


<210>  156
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Asp Glu Thr Ser Pro Leu Val Ser Pro Glu Arg Ala Gln Pro Pro 
1               5                   10                  15      


Asp Tyr Thr Phe Pro Ser Gly Ser Gly Ala His Phe Pro Gln Val Pro 
            20                  25                  30          


Gly Gly Ala Val Arg Val Ala Ala Ala Ala Gly Ser Gly Pro Ser Pro 
        35                  40                  45              


Pro Gly Ser Pro Gly His Asp Arg Glu Arg Gln Pro Leu Leu Asp Arg 
    50                  55                  60                  


Ala Arg Gly Ala Ala Ala Gln Gly Gln Thr Gln Thr Val Ala Ala Gln 
65                  70                  75                  80  


Ala Gln Ala Leu Ala Ala Gln Ala Ala Ala Ala Ala His Ala Ala Gln 
                85                  90                  95      


Ala His Arg Glu Arg Asn Glu Phe Pro Glu Asp Pro Glu Phe Glu Ala 
            100                 105                 110         


Val Val Arg Gln Ala Glu Leu Ala Ile Glu Arg Cys Ile Phe Pro Glu 
        115                 120                 125             


Arg Ile Tyr Gln Gly Ser Ser Gly Ser Tyr Phe Val Lys Asp Pro Gln 
    130                 135                 140                 


Gly Arg Ile Ile Ala Val Phe Lys Pro Lys Asn Glu Glu Pro Tyr Gly 
145                 150                 155                 160 


His Leu Asn Pro Lys Trp Thr Lys Trp Leu Gln Lys Leu Cys Cys Pro 
                165                 170                 175     


Cys Cys Phe Gly Arg Asp Cys Leu Val Leu Asn Gln Gly Tyr Leu Ser 
            180                 185                 190         


Glu Ala Gly Ala Ser Leu Val Asp Gln Lys Leu Glu Leu Asn Ile Val 
        195                 200                 205             


Pro Arg Thr Lys Val Val Tyr Leu Ala Ser Glu Thr Phe Asn Tyr Ser 
    210                 215                 220                 


Ala Ile Asp Arg Val Lys Ser Arg Gly Lys Arg Leu Ala Leu Glu Lys 
225                 230                 235                 240 


Val Pro Lys Val Gly Gln Arg Phe Asn Arg Ile Gly Leu Pro Pro Lys 
                245                 250                 255     


Val Gly Ser Phe Gln Leu Phe Val Glu Gly Tyr Lys Asp Ala Asp Tyr 
            260                 265                 270         


Trp Leu Arg Arg Phe Glu Ala Glu Pro Leu Pro Glu Asn Thr Asn Arg 
        275                 280                 285             


Gln Leu Leu Leu Gln Phe Glu Arg Leu Val Val Leu Asp Tyr Ile Ile 
    290                 295                 300                 


Arg Asn Thr Asp Arg Gly Asn Asp Asn Trp Leu Ile Lys Tyr Asp Cys 
305                 310                 315                 320 


Pro Met Asp Ser Ser Ser Ser Arg Asp Thr Asp Trp Val Val Val Lys 
                325                 330                 335     


Glu Pro Val Ile Lys Val Ala Ala Ile Asp Asn Gly Leu Ala Phe Pro 
            340                 345                 350         


Leu Lys His Pro Asp Ser Trp Arg Ala Tyr Pro Phe Tyr Trp Ala Trp 
        355                 360                 365             


Leu Pro Gln Ala Lys Val Pro Phe Ser Gln Glu Ile Lys Asp Leu Ile 
    370                 375                 380                 


Leu Pro Lys Ile Ser Asp Pro Asn Phe Val Lys Asp Leu Glu Glu Asp 
385                 390                 395                 400 


Leu Tyr Glu Leu Phe Lys Lys Asp Pro Gly Phe Asp Arg Gly Gln Phe 
                405                 410                 415     


His Lys Gln Ile Ala Val Met Arg Gly Gln Ile Leu Asn Leu Thr Gln 
            420                 425                 430         


Ala Leu Lys Asp Asn Lys Ser Pro Leu His Leu Val Gln Met Pro Pro 
        435                 440                 445             


Val Ile Val Glu Thr Ala Arg Ser His Gln Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


Tyr Thr Gln Ser Phe Gln Ser Arg Lys Pro Phe Phe Ser Trp Trp 
465                 470                 475                 


<210>  157
<211>  1440
<212>  DNA
<213>  Mus musculus

<400>  157
atggacgaga cgagcccgct agtgtccccc gagcgggccc aacccccgga gtacaccttc       60

ccgtcgggct ccggagctca ctttccgcaa gtaccggggg gcgcggtccg cgtggcggcg      120

gcggccggct ccggcccgtc accgccgtgc tcgcccggcc acgaccggga gcggcagccc      180

ctgctggacc gggcccgggg cgcggcggcg cagggccaga cccacacggt ggcggtgcag      240

gcccaggccc tggccgccca agcggccgtg gcggcgcacg ccgttcagac ccaccgcgag      300

cggaacgact tcccggagga ccccgagttc gaggtggtgg tgcggcaggc cgaggttgcc      360

atcgagtgca gcatctatcc cgagcgcatc taccagggct ccagtggaag ctacttcgtc      420

aaggactctc aggggagaat cgttgctgtc ttcaaaccca agaatgaaga gccatacggg      480

caccttaacc ctaagtggac caagtggctg cagaagctgt gctgcccctg ctgctttggc      540

cgagactgcc ttgttctcaa ccagggctat ctctcagagg caggggctag cctggtggac      600

caaaaactgg aactcaacat tgtaccacgt acaaaggtag tatacctggc cagtgaaacc      660

ttcaactaca gtgccattga tcgagtaaag tccaggggca agcggcttgc actagagaaa      720

gtgccaaaag ttgggcagcg gtttaaccga atcggcctgc caccaaaggt cgggtcattc      780

cagctcttcg ttgaaggcta caaagatgca gactattggc tgcggcgttt tgaagcagaa      840

cctctccctg agaacacgaa ccgacagctg ctattgcagt ttgagcggtt ggtggtcctg      900

gactacatca tccgcaacac tgaccgaggc aatgacaact ggttgatcaa atatgactgt      960

ccgatggata attctagctg tcgggacaca gattgggtga tggtgaggga gcctgttatc     1020

aaggtggctg ccatagacaa cgggctagct ttcccactga agcatcctga ctcctggagg     1080

gcatatcctt tttactgggc ctggctgcct caggcgaaag tcccgttctc tcaggagatc     1140

aaagatttga ttcttccaaa gatttcagac cctaacttca tcaaggactt ggaggaggac     1200

ctatatgaac tcttcaagag agatcctggc ttcgacaggg gccagttcca taagcagatt     1260

gctgtcatga gaggccagat cctaaatttg acccaggccc tgaaagacaa taagagcccc     1320

ctgcacctcg tccagatgcc acctgtgatt gtcgagacgg cccgctctca ccagcggtct     1380

gcaagcgaat cctacacaca gagctttcag agtcggaagc ccttcttttc atggtggtag     1440


<210>  158
<211>  479
<212>  PRT
<213>  Mus musculus

<400>  158

Met Asp Glu Thr Ser Pro Leu Val Ser Pro Glu Arg Ala Gln Pro Pro 
1               5                   10                  15      


Glu Tyr Thr Phe Pro Ser Gly Ser Gly Ala His Phe Pro Gln Val Pro 
            20                  25                  30          


Gly Gly Ala Val Arg Val Ala Ala Ala Ala Gly Ser Gly Pro Ser Pro 
        35                  40                  45              


Pro Cys Ser Pro Gly His Asp Arg Glu Arg Gln Pro Leu Leu Asp Arg 
    50                  55                  60                  


Ala Arg Gly Ala Ala Ala Gln Gly Gln Thr His Thr Val Ala Val Gln 
65                  70                  75                  80  


Ala Gln Ala Leu Ala Ala Gln Ala Ala Val Ala Ala His Ala Val Gln 
                85                  90                  95      


Thr His Arg Glu Arg Asn Asp Phe Pro Glu Asp Pro Glu Phe Glu Val 
            100                 105                 110         


Val Val Arg Gln Ala Glu Val Ala Ile Glu Cys Ser Ile Tyr Pro Glu 
        115                 120                 125             


Arg Ile Tyr Gln Gly Ser Ser Gly Ser Tyr Phe Val Lys Asp Ser Gln 
    130                 135                 140                 


Gly Arg Ile Val Ala Val Phe Lys Pro Lys Asn Glu Glu Pro Tyr Gly 
145                 150                 155                 160 


His Leu Asn Pro Lys Trp Thr Lys Trp Leu Gln Lys Leu Cys Cys Pro 
                165                 170                 175     


Cys Cys Phe Gly Arg Asp Cys Leu Val Leu Asn Gln Gly Tyr Leu Ser 
            180                 185                 190         


Glu Ala Gly Ala Ser Leu Val Asp Gln Lys Leu Glu Leu Asn Ile Val 
        195                 200                 205             


Pro Arg Thr Lys Val Val Tyr Leu Ala Ser Glu Thr Phe Asn Tyr Ser 
    210                 215                 220                 


Ala Ile Asp Arg Val Lys Ser Arg Gly Lys Arg Leu Ala Leu Glu Lys 
225                 230                 235                 240 


Val Pro Lys Val Gly Gln Arg Phe Asn Arg Ile Gly Leu Pro Pro Lys 
                245                 250                 255     


Val Gly Ser Phe Gln Leu Phe Val Glu Gly Tyr Lys Asp Ala Asp Tyr 
            260                 265                 270         


Trp Leu Arg Arg Phe Glu Ala Glu Pro Leu Pro Glu Asn Thr Asn Arg 
        275                 280                 285             


Gln Leu Leu Leu Gln Phe Glu Arg Leu Val Val Leu Asp Tyr Ile Ile 
    290                 295                 300                 


Arg Asn Thr Asp Arg Gly Asn Asp Asn Trp Leu Ile Lys Tyr Asp Cys 
305                 310                 315                 320 


Pro Met Asp Asn Ser Ser Cys Arg Asp Thr Asp Trp Val Met Val Arg 
                325                 330                 335     


Glu Pro Val Ile Lys Val Ala Ala Ile Asp Asn Gly Leu Ala Phe Pro 
            340                 345                 350         


Leu Lys His Pro Asp Ser Trp Arg Ala Tyr Pro Phe Tyr Trp Ala Trp 
        355                 360                 365             


Leu Pro Gln Ala Lys Val Pro Phe Ser Gln Glu Ile Lys Asp Leu Ile 
    370                 375                 380                 


Leu Pro Lys Ile Ser Asp Pro Asn Phe Ile Lys Asp Leu Glu Glu Asp 
385                 390                 395                 400 


Leu Tyr Glu Leu Phe Lys Arg Asp Pro Gly Phe Asp Arg Gly Gln Phe 
                405                 410                 415     


His Lys Gln Ile Ala Val Met Arg Gly Gln Ile Leu Asn Leu Thr Gln 
            420                 425                 430         


Ala Leu Lys Asp Asn Lys Ser Pro Leu His Leu Val Gln Met Pro Pro 
        435                 440                 445             


Val Ile Val Glu Thr Ala Arg Ser His Gln Arg Ser Ala Ser Glu Ser 
    450                 455                 460                 


Tyr Thr Gln Ser Phe Gln Ser Arg Lys Pro Phe Phe Ser Trp Trp 
465                 470                 475                 


<210>  159
<211>  2187
<212>  DNA
<213>  Homo sapiens

<400>  159
atggcgggcc ctgagggctt ccagtaccgc gctctgtacc cgttccgccg ggagcggccg       60

gaggacctgg agctgctgcc cggcgacgtg ctggtagtga gccgggcggc cttgcaggcg      120

ctgggcgtgg ccgagggtgg cgagcgctgc ccacagagcg tgggctggat gcccggcctc      180

aacgagcgca cacggcagcg aggtgacttc cctggcacct atgtggagtt cctggggccc      240

gtggccctgg cccggcccgg ccctcgccca cggggccccc gcccactgcc cgccaggccc      300

cgtgatgggg cccctgagcc aggcctcaca ctccccgact tgcccgagca gttctcccca      360

cctgatgtgg ctccccctct tctggtgaag cttgtggagg ccattgaaag gacagggctg      420

gacagcgaat ctcactaccg cccggagctg cccgcaccgc gtacagactg gtccctgagc      480

gacgtggatc agtgggacac ggcagccctg gctgacggca ttaagagctt cctgctggca      540

ctgcccgcgc cgctcgtgac ccccgaggcc tcggccgagg cgcgccgggc cctgcgggag      600

gccgcggggc ccgtggggcc ggcgctggag ccaccgacgc tgccgctgca ccgcgcgctc      660

acgctgcgct tcctgctcca gcacctgggc cgcgtggccc gccgcgcccc ggccctgggt      720

cccgcggtcc gggccctggg cgccaccttt gggccgctgc tgctgcgcgc gccgccgccg      780

ccgtcctcgc cgccgccagg gggcgctccc gacgggagtg agcccagccc tgacttcccg      840

gcgctgctgg tggagaagct gcttcaggaa cacttggaag agcaggaggt tgcgccccca      900

gcgctgccgc ctaaaccccc caaggcaaag ccggccccca cagtcctggc caatggaggg      960

agcccaccct ccctgcagga tgctgagtgg tactgggggg acatttcaag ggaggaggtg     1020

aacgagaaac tccgggacac tcccgatggc accttcctag tccgagatgc ttctagcaag     1080

atccagggcg agtacacgct gaccctcagg aaaggcggga acaataagct gatcaaggtc     1140

ttccaccgag atgggcacta tggcttctca gagccactca ccttctgctc cgttgtggac     1200

ctcatcaatc actaccgcca cgagtctctg gcccagtaca atgccaagct ggacacacgg     1260

ctcctctacc ctgtgtccaa ataccagcag gaccagattg tcaaggagga cagcgtggag     1320

gcagtgggcg cccagcttaa ggtctatcac cagcagtacc aggacaagag ccgcgagtat     1380

gaccagcttt atgaagagta cacacggacc tcccaggagc tgcagatgaa gcgtactgca     1440

attgaggcct tcaatgagac tatcaagatc tttgaagagc agggccagac tcaagagaaa     1500

tgcagcaagg aatacctgga gcgcttccgg cgtgagggca acgagaaaga gatgcaaagg     1560

atcctgctga actccgagcg gctcaagtcc cgcattgccg agatccatga gagccgcacg     1620

aagctggagc agcagctgcg ggcccaggcc tcggacaaca gagagatcga caagcgcatg     1680

aacagcctca agccggacct catgcagctg cgcaagatcc gagaccagta cctcgtgtgg     1740

ctcacccaga aaggcgcccg gcagaagaaa atcaacgagt ggctggggat taaaaatgag     1800

actgaggacc agtacgcact catggaggac gaggacgatc tcccgcacca cgaggaacgc     1860

acttggtacg tgggcaagat caaccgcacg caggcagagg agatgctgag tggcaagcgg     1920

gatggcacct tcctcatccg cgagagcagc cagcggggct gctacgcctg ctccgtggta     1980

gtggacggcg acaccaagca ctgcgtcatc taccgcacgg ccaccggctt cggcttcgcg     2040

gagccctaca acctgtacgg gtcgctgaag gagctggtgc tgcactacca gcacgcctcg     2100

ctggtgcagc acaacgacgc gctcaccgtc accctggcgc acccagtgcg cgccccgggc     2160

cccggcccgc cgcctgccgc ccgctga                                         2187


<210>  160
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Gly Pro Glu Gly Phe Gln Tyr Arg Ala Leu Tyr Pro Phe Arg 
1               5                   10                  15      


Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Val Leu Val 
            20                  25                  30          


Val Ser Arg Ala Ala Leu Gln Ala Leu Gly Val Ala Glu Gly Gly Glu 
        35                  40                  45              


Arg Cys Pro Gln Ser Val Gly Trp Met Pro Gly Leu Asn Glu Arg Thr 
    50                  55                  60                  


Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
65                  70                  75                  80  


Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                85                  90                  95      


Pro Ala Arg Pro Arg Asp Gly Ala Pro Glu Pro Gly Leu Thr Leu Pro 
            100                 105                 110         


Asp Leu Pro Glu Gln Phe Ser Pro Pro Asp Val Ala Pro Pro Leu Leu 
        115                 120                 125             


Val Lys Leu Val Glu Ala Ile Glu Arg Thr Gly Leu Asp Ser Glu Ser 
    130                 135                 140                 


His Tyr Arg Pro Glu Leu Pro Ala Pro Arg Thr Asp Trp Ser Leu Ser 
145                 150                 155                 160 


Asp Val Asp Gln Trp Asp Thr Ala Ala Leu Ala Asp Gly Ile Lys Ser 
                165                 170                 175     


Phe Leu Leu Ala Leu Pro Ala Pro Leu Val Thr Pro Glu Ala Ser Ala 
            180                 185                 190         


Glu Ala Arg Arg Ala Leu Arg Glu Ala Ala Gly Pro Val Gly Pro Ala 
        195                 200                 205             


Leu Glu Pro Pro Thr Leu Pro Leu His Arg Ala Leu Thr Leu Arg Phe 
    210                 215                 220                 


Leu Leu Gln His Leu Gly Arg Val Ala Arg Arg Ala Pro Ala Leu Gly 
225                 230                 235                 240 


Pro Ala Val Arg Ala Leu Gly Ala Thr Phe Gly Pro Leu Leu Leu Arg 
                245                 250                 255     


Ala Pro Pro Pro Pro Ser Ser Pro Pro Pro Gly Gly Ala Pro Asp Gly 
            260                 265                 270         


Ser Glu Pro Ser Pro Asp Phe Pro Ala Leu Leu Val Glu Lys Leu Leu 
        275                 280                 285             


Gln Glu His Leu Glu Glu Gln Glu Val Ala Pro Pro Ala Leu Pro Pro 
    290                 295                 300                 


Lys Pro Pro Lys Ala Lys Pro Ala Pro Thr Val Leu Ala Asn Gly Gly 
305                 310                 315                 320 


Ser Pro Pro Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser 
                325                 330                 335     


Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Pro Asp Gly Thr Phe 
            340                 345                 350         


Leu Val Arg Asp Ala Ser Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr 
        355                 360                 365             


Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Val Phe His Arg Asp 
    370                 375                 380                 


Gly His Tyr Gly Phe Ser Glu Pro Leu Thr Phe Cys Ser Val Val Asp 
385                 390                 395                 400 


Leu Ile Asn His Tyr Arg His Glu Ser Leu Ala Gln Tyr Asn Ala Lys 
                405                 410                 415     


Leu Asp Thr Arg Leu Leu Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln 
            420                 425                 430         


Ile Val Lys Glu Asp Ser Val Glu Ala Val Gly Ala Gln Leu Lys Val 
        435                 440                 445             


Tyr His Gln Gln Tyr Gln Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr 
    450                 455                 460                 


Glu Glu Tyr Thr Arg Thr Ser Gln Glu Leu Gln Met Lys Arg Thr Ala 
465                 470                 475                 480 


Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu Gln Gly Gln 
                485                 490                 495     


Thr Gln Glu Lys Cys Ser Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu 
            500                 505                 510         


Gly Asn Glu Lys Glu Met Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu 
        515                 520                 525             


Lys Ser Arg Ile Ala Glu Ile His Glu Ser Arg Thr Lys Leu Glu Gln 
    530                 535                 540                 


Gln Leu Arg Ala Gln Ala Ser Asp Asn Arg Glu Ile Asp Lys Arg Met 
545                 550                 555                 560 


Asn Ser Leu Lys Pro Asp Leu Met Gln Leu Arg Lys Ile Arg Asp Gln 
                565                 570                 575     


Tyr Leu Val Trp Leu Thr Gln Lys Gly Ala Arg Gln Lys Lys Ile Asn 
            580                 585                 590         


Glu Trp Leu Gly Ile Lys Asn Glu Thr Glu Asp Gln Tyr Ala Leu Met 
        595                 600                 605             


Glu Asp Glu Asp Asp Leu Pro His His Glu Glu Arg Thr Trp Tyr Val 
    610                 615                 620                 


Gly Lys Ile Asn Arg Thr Gln Ala Glu Glu Met Leu Ser Gly Lys Arg 
625                 630                 635                 640 


Asp Gly Thr Phe Leu Ile Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala 
                645                 650                 655     


Cys Ser Val Val Val Asp Gly Asp Thr Lys His Cys Val Ile Tyr Arg 
            660                 665                 670         


Thr Ala Thr Gly Phe Gly Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser 
        675                 680                 685             


Leu Lys Glu Leu Val Leu His Tyr Gln His Ala Ser Leu Val Gln His 
    690                 695                 700                 


Asn Asp Ala Leu Thr Val Thr Leu Ala His Pro Val Arg Ala Pro Gly 
705                 710                 715                 720 


Pro Gly Pro Pro Pro Ala Ala Arg 
                725             


<210>  161
<211>  2169
<212>  DNA
<213>  Mus musculus

<400>  161
atggcaggag ccgagggctt ccagtacagg gctgtgtacc cattccgccg ggagcggcct       60

gaagacctgg agctgctccc tggggacctc ctggtggtga gccgggtggc cctacaggca      120

cttggtgtgg ctgatggagg agagcgctgc ccacacaatg tgggctggat gcctggcttc      180

aacgagcgca cccgacagcg aggggacttc cccgggacat acgtggagtt cctaggaccc      240

gtggctctgg ctcgaccagg ccctcgccca cgggggcccc gtccgttgcc cgccaggccc      300

ttggatggat cttctgagtc aggccacata ctcccagacc tggcagagca gttctcccca      360

cctgaccctg ctcccccgat tctggtgaag ctggtggaag ccattgagca agcagagctg      420

gacagtgaat gctacagtaa gccggagctg cccgcaacac ggacagactg gtccctgagt      480

gacttggagc agtgggaccg caccgccttg tatgatgctg ttaagggctt cctgctggcg      540

ttgcctgcag ctgtggtgac ccctgaagct gcagcagagg cgtaccgggc acttcgagag      600

gttgcaggcc ccgtggggct ggtgctggaa cccccaacac tgccgctgca ccaggctctc      660

acactgcgtt tcctgctgca acacctgggt cgtgtggccc gcagagcacc ctcgccagat      720

acagctgtcc atgcactggc cagtgccttc gggccgctac tgctgcgcat acctccgtca      780

gggggcgagg gtgatgggag tgagcctgta cccgacttcc ctgtgctgct gctagagagg      840

ctggtgcagg agcatgtgga ggagcaagac gctgcccccc cagcgctacc acctaagccc      900

tctaaggcaa agccggcacc cacagctctg gccaatggag ggagcccgcc ctcgcttcag      960

gatgcagagt ggtactgggg ggacatctcc agggaagagg tgaatgagag actccgggac     1020

acacctgatg gtaccttctt agtcagagat gcatccagca agatccaagg agagtacacg     1080

ctcaccctca ggaaaggcgg gaacaacaag ttgatcaaag tcttccaccg ggatggtcac     1140

tatggcttct cagagcccct taccttctgc tccgtggtgg aactcatctc ccactaccgc     1200

cacgaatcac tggcccagta caacgccaag ctggacacac gccttctcta ccctgtgtcc     1260

aagtaccaac aagaccaggt ggtgaaggag gacagcatag aggctgtggg cgcccagctc     1320

aaggtctacc accagcagta ccaggacaag agccgcgaat atgaccagct gtatgaagaa     1380

tacacacgga cctcccagga gctgcagatg aagcgcacag ccatagaggc cttcaacgag     1440

accatcaaga tcttcgaaga gcagggccag acacaggaga aatgcagcaa ggagtatttg     1500

gagcgcttcc ggcgagaggg aaatgagaag gagatgcaga ggatcctgct gaactccgag     1560

cgactcaagt ctcgcatcgc ggagatacac gaaagccgca cgaagttgga gcaggatctg     1620

cgggcgcagg cctccgacaa ccgtgagatc gacaagcgca tgaacagcct caaacctgac     1680

ctcatgcagc tgcgcaagat cagggaccag tacctcgtgt ggctcaccca gaaaggtgcc     1740

cgacagagga agatcaacga atggctggga atcaagaacg agactgagga ccagtattca     1800

ctgatggagg atgaggacgc cctcccccac cacgaggagc gcacgtggta cgtgggcaag     1860

atcaaccgca cacaggcgga ggagatgctg agtggcaaac gagacgggac cttcctcatc     1920

cgggagagca gccagcgggg ctgttacgca tgctccgtgg tggtggacgg cgacacgaag     1980

cactgtgtca tctaccgcac agccaccggc ttcggcttcg cagagcccta taacctgtac     2040

gggtccctga aggagctggt gctgcactac cagcacgcat cactcgtgca gcacaatgac     2100

gcacttaccg tcaccctcgc acaccctgtg cgtgcccccg ggcctggccc accgtctgca     2160

gcacgctga                                                             2169


<210>  162
<211>  722
<212>  PRT
<213>  Mus musculus

<400>  162

Met Ala Gly Ala Glu Gly Phe Gln Tyr Arg Ala Val Tyr Pro Phe Arg 
1               5                   10                  15      


Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Leu Leu Val 
            20                  25                  30          


Val Ser Arg Val Ala Leu Gln Ala Leu Gly Val Ala Asp Gly Gly Glu 
        35                  40                  45              


Arg Cys Pro His Asn Val Gly Trp Met Pro Gly Phe Asn Glu Arg Thr 
    50                  55                  60                  


Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
65                  70                  75                  80  


Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                85                  90                  95      


Pro Ala Arg Pro Leu Asp Gly Ser Ser Glu Ser Gly His Ile Leu Pro 
            100                 105                 110         


Asp Leu Ala Glu Gln Phe Ser Pro Pro Asp Pro Ala Pro Pro Ile Leu 
        115                 120                 125             


Val Lys Leu Val Glu Ala Ile Glu Gln Ala Glu Leu Asp Ser Glu Cys 
    130                 135                 140                 


Tyr Ser Lys Pro Glu Leu Pro Ala Thr Arg Thr Asp Trp Ser Leu Ser 
145                 150                 155                 160 


Asp Leu Glu Gln Trp Asp Arg Thr Ala Leu Tyr Asp Ala Val Lys Gly 
                165                 170                 175     


Phe Leu Leu Ala Leu Pro Ala Ala Val Val Thr Pro Glu Ala Ala Ala 
            180                 185                 190         


Glu Ala Tyr Arg Ala Leu Arg Glu Val Ala Gly Pro Val Gly Leu Val 
        195                 200                 205             


Leu Glu Pro Pro Thr Leu Pro Leu His Gln Ala Leu Thr Leu Arg Phe 
    210                 215                 220                 


Leu Leu Gln His Leu Gly Arg Val Ala Arg Arg Ala Pro Ser Pro Asp 
225                 230                 235                 240 


Thr Ala Val His Ala Leu Ala Ser Ala Phe Gly Pro Leu Leu Leu Arg 
                245                 250                 255     


Ile Pro Pro Ser Gly Gly Glu Gly Asp Gly Ser Glu Pro Val Pro Asp 
            260                 265                 270         


Phe Pro Val Leu Leu Leu Glu Arg Leu Val Gln Glu His Val Glu Glu 
        275                 280                 285             


Gln Asp Ala Ala Pro Pro Ala Leu Pro Pro Lys Pro Ser Lys Ala Lys 
    290                 295                 300                 


Pro Ala Pro Thr Ala Leu Ala Asn Gly Gly Ser Pro Pro Ser Leu Gln 
305                 310                 315                 320 


Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser Arg Glu Glu Val Asn Glu 
                325                 330                 335     


Arg Leu Arg Asp Thr Pro Asp Gly Thr Phe Leu Val Arg Asp Ala Ser 
            340                 345                 350         


Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr Leu Arg Lys Gly Gly Asn 
        355                 360                 365             


Asn Lys Leu Ile Lys Val Phe His Arg Asp Gly His Tyr Gly Phe Ser 
    370                 375                 380                 


Glu Pro Leu Thr Phe Cys Ser Val Val Glu Leu Ile Ser His Tyr Arg 
385                 390                 395                 400 


His Glu Ser Leu Ala Gln Tyr Asn Ala Lys Leu Asp Thr Arg Leu Leu 
                405                 410                 415     


Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln Val Val Lys Glu Asp Ser 
            420                 425                 430         


Ile Glu Ala Val Gly Ala Gln Leu Lys Val Tyr His Gln Gln Tyr Gln 
        435                 440                 445             


Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr Glu Glu Tyr Thr Arg Thr 
    450                 455                 460                 


Ser Gln Glu Leu Gln Met Lys Arg Thr Ala Ile Glu Ala Phe Asn Glu 
465                 470                 475                 480 


Thr Ile Lys Ile Phe Glu Glu Gln Gly Gln Thr Gln Glu Lys Cys Ser 
                485                 490                 495     


Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu Gly Asn Glu Lys Glu Met 
            500                 505                 510         


Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu Lys Ser Arg Ile Ala Glu 
        515                 520                 525             


Ile His Glu Ser Arg Thr Lys Leu Glu Gln Asp Leu Arg Ala Gln Ala 
    530                 535                 540                 


Ser Asp Asn Arg Glu Ile Asp Lys Arg Met Asn Ser Leu Lys Pro Asp 
545                 550                 555                 560 


Leu Met Gln Leu Arg Lys Ile Arg Asp Gln Tyr Leu Val Trp Leu Thr 
                565                 570                 575     


Gln Lys Gly Ala Arg Gln Arg Lys Ile Asn Glu Trp Leu Gly Ile Lys 
            580                 585                 590         


Asn Glu Thr Glu Asp Gln Tyr Ser Leu Met Glu Asp Glu Asp Ala Leu 
        595                 600                 605             


Pro His His Glu Glu Arg Thr Trp Tyr Val Gly Lys Ile Asn Arg Thr 
    610                 615                 620                 


Gln Ala Glu Glu Met Leu Ser Gly Lys Arg Asp Gly Thr Phe Leu Ile 
625                 630                 635                 640 


Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala Cys Ser Val Val Val Asp 
                645                 650                 655     


Gly Asp Thr Lys His Cys Val Ile Tyr Arg Thr Ala Thr Gly Phe Gly 
            660                 665                 670         


Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser Leu Lys Glu Leu Val Leu 
        675                 680                 685             


His Tyr Gln His Ala Ser Leu Val Gln His Asn Asp Ala Leu Thr Val 
    690                 695                 700                 


Thr Leu Ala His Pro Val Arg Ala Pro Gly Pro Gly Pro Pro Ser Ala 
705                 710                 715                 720 


Ala Arg 
        


<210>  163
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  163
atggagccct ggcctctcct cctgctcttt agcctttgct cagctggcct cgtcctgggc       60

tccgaacatg agacccgtct ggtggcaaag ctatttaaag actacagcag cgtggtgcgg      120

ccagtggaag accaccgcca ggtcgtggag gtcaccgtgg gcctgcagct gatacagctc      180

atcaatgtgg atgaagtaaa tcagatcgtg acaaccaatg tgcgtctgaa acagggtgac      240

atggtagatc tgccacgccc cagctgcgtg actttgggag ttcctttgtt ttctcatctg      300

cagaatgagc aatgggtgga ttacaaccta aaatggaatc cagatgacta tggcggtgtg      360

aaaaaaattc acattccttc agaaaagatc tggcgcccag accttgttct ctataacaat      420

gcagatggtg actttgctat tgtcaagttc accaaagtgc tcctgcagta cactggccac      480

atcacgtgga cacctccagc catctttaaa agctactgtg agatcatcgt cacccacttt      540

ccctttgatg aacagaactg cagcatgaag ctgggcacct ggacctacga cggctctgtc      600

gtggccatca acccggaaag cgaccagcca gacctgagca acttcatgga gagcggggag      660

tgggtgatca aggagtcccg gggctggaag cactccgtga cctattcctg ctgccccgac      720

accccctacc tggacatcac ctaccacttc gtcatgcagc gcctgcccct ctacttcatc      780

gtcaacgtca tcatcccctg cctgctcttc tccttcttaa ctggcctggt attctacctg      840

cccacagact caggggagaa gatgactctg agcatctctg tcttactgtc tttgactgtg      900

ttccttctgg tcatcgtgga gctgatcccc tccacgtcca gtgctgtgcc cttgattgga      960

aaatacatgc tgttcaccat ggtgttcgtc attgcctcca tcatcatcac tgtcatcgtc     1020

atcaacacac accaccgctc acccagcacc catgtcatgc ccaactgggt gcggaaggtt     1080

tttatcgaca ctatcccaaa tatcatgttt ttctccacaa tgaaaagacc atccagagaa     1140

aagcaagaca aaaagatttt tacagaagac attgatatct ctgacatttc tggaaagcca     1200

gggcctccac ccatgggctt ccactctccc ctgatcaaac accccgaggt gaaaagtgcc     1260

atcgagggca tcaagtacat cgcagagacc atgaagtcag accaggagtc taacaatgcg     1320

gcggcagagt ggaagtacgt tgcaatggtg atggaccaca tactcctcgg agtcttcatg     1380

cttgtttgca tcatcggaac cctagccgtg tttgcaggtc gactcattga attaaatcag     1440

caaggatga                                                             1449


<210>  164
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  164
atggagccct ggcctctcct cctgctcttt agcctttgct cagctggcct cgtcctgggc       60

tccgaacatg agacccgtct ggtggcaaag ctatttaaag actacagcag cgtggtgcgg      120

ccagtggaag accaccgcca ggtcgtggag gtcaccgtgg gcctgcagct gatacagctc      180

atcaatgtgg atgaagtaaa tcagatcgtg acaaccaatg tgcgtctgaa acagcaatgg      240

gtggattaca acctaaaatg gaatccagat gactatggcg gtgtgaaaaa aattcacatt      300

ccttcagaaa agatctggcg cccagacctt gttctctata acaatgcaga tggtgacttt      360

gctattgtca agttcaccaa agtgctcctg cagtacactg gccacatcac gtggacacct      420

ccagccatct ttaaaagcta ctgtgagatc atcgtcaccc actttccctt tgatgaacag      480

aactgcagca tgaagctggg cacctggacc tacgacggct ctgtcgtggc catcaacccg      540

gaaagcgacc agccagacct gagcaacttc atggagagcg gggagtgggt gatcaaggag      600

tcccggggct ggaagcactc cgtgacctat tcctgctgcc ccgacacccc ctacctggac      660

atcacctacc acttcgtcat gcagcgcctg cccctctact tcatcgtcaa cgtcatcatc      720

ccctgcctgc tcttctcctt cttaactggc ctggtattct acctgcccac agactcaggg      780

gagaagatga ctctgagcat ctctgtctta ctgtctttga ctgtgttcct tctggtcatc      840

gtggagctga tcccctccac gtccagtgct gtgcccttga ttggaaaata catgctgttc      900

accatggtgt tcgtcattgc ctccatcatc atcactgtca tcgtcatcaa cacacaccac      960

cgctcaccca gcacccatgt catgcccaac tgggtgcgga aggtttttat cgacactatc     1020

ccaaatatca tgtttttctc cacaatgaaa agaccatcca gagaaaagca agacaaaaag     1080

atttttacag aagacattga tatctctgac atttctggaa agccagggcc tccacccatg     1140

ggcttccact ctcccctgat caaacacccc gaggtgaaaa gtgccatcga gggcatcaag     1200

tacatcgcag agaccatgaa gtcagaccag gagtctaaca atgcggcggc agagtggaag     1260

tacgttgcaa tggtgatgga ccacatactc ctcggagtct tcatgcttgt ttgcatcatc     1320

ggaaccctag ccgtgtttgc aggtcgactc attgaattaa atcagcaagg atga           1374


<210>  165
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  166
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210>  167
<211>  1374
<212>  DNA
<213>  Mus musculus

<400>  167
atggagctct cgactgttct cctgctgcta ggcctctgct ccgctggcct tgttctgggc       60

tccgaacatg agacgcgtct ggtggcaaag ctctttgaag actacagcag tgtagtccgg      120

ccagtggagg accaccgtga gattgtacaa gtcaccgtgg gtctacagct gatccagctt      180

atcaatgtgg atgaagtaaa tcagattgtg acaaccaatg tacgtctgaa acagcaatgg      240

gtcgattaca acttgaaatg gaatccagat gactatggag gagtgaaaaa aattcacatc      300

ccctcggaaa agatctggcg gccggacgtc gttctctata acaacgcaga cggcgacttt      360

gccattgtca aattcaccaa ggtgctcctg gactacaccg gccacatcac ctggacaccg      420

ccagccatct ttaaaagcta ctgtgagatc attgtcactc actttccctt cgatgagcag      480

aactgcagca tgaagctggg cacctggacc tatgacggct ctgtggtggc cattaacccg      540

gaaagtgacc agcccgacct gagtaacttc atggagagcg gggagtgggt gatcaaggaa      600

gctcggggct ggaagcactg ggtgttctac tcctgctgcc ccaccactcc ctacctggac      660

atcacctacc acttcgtcat gcagcgcctg cccctctact tcattgtcaa cgtcatcatt      720

ccctgcctgc tcttctcctt cttaaccagc ctggtgttct acctgcccac agactcaggg      780

gagaagatga cgctgagcat ctctgtctta ctgtccctga ccgtgttcct tctggtcatt      840

gtggagctaa tcccttccac ctccagcgct gtgcccctga tcgggaagta tatgttgttc      900

accatggtct ttgtcattgc gtccatcatc atcaccgtca tcgtcatcaa cacacaccac      960

cgttcgccca gcacccacat catgcccgag tgggtgcgga aggtttttat cgacactatc     1020

ccaaacatca tgtttttctc cacaatgaaa agaccatcca gagataaaca agagaaaagg     1080

atttttacag aagacataga tatatctgac atctctggga agccgggtcc tccacctatg     1140

ggctttcact ctccgctgat caagcaccct gaggtgaaaa gcgccatcga gggcgtgaag     1200

tacattgcag agaccatgaa gtcagaccag gagtccaata acgccgctga ggaatggaag     1260

tatgttgcca tggtgatgga tcacatcctc ctcggagtct ttatgctggt gtgtctcatc     1320

gggacgctgg ctgtgtttgc aggtcggctc attgagttac atcaacaagg atga           1374


<210>  168
<211>  457
<212>  PRT
<213>  Mus musculus

<400>  168

Met Glu Leu Ser Thr Val Leu Leu Leu Leu Gly Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Glu Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Glu Ile 
        35                  40                  45              


Val Gln Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Val Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Asp Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ala Arg Gly Trp Lys His Trp Val 
        195                 200                 205             


Phe Tyr Ser Cys Cys Pro Thr Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Ser Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Ile Met Pro Glu Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Asp Lys Gln Glu Lys Arg Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Val Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Glu Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Leu Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu His Gln Gln Gly 
    450                 455         


<210>  169
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  169
atggcgacct ccacgggtcg ctggcttctc ctccggcttg cactattcgg cttcctctgg       60

gaagcgtccg gcggcctcga ctcgggggcc tcccgcgacg acgacttgct actgccctat      120

ccacgcgcgc gcgcgcgcct cccccgggac tgcacacggg tgcgcgccgg caaccgcgag      180

cacgagagtt ggcctccgcc tcccgcgact cccggcgccg gcggtctggc cgtgcgcacc      240

ttcgtgtcgc acttcaggga ccgcgcggtg gccggccacc tgacgcgggc cgttgagccc      300

ctgcgcacct tctcggtgct ggagcccggt ggacccggcg gctgcgcggc gagacgacgc      360

gccaccgtgg aggagacggc gcgggcggcc gactgccgtg tcgcccagaa cggcggcttc      420

ttccgcatga actcgggcga gtgcctgggg aacgtggtga gcgacgagcg gcgggtgagc      480

agctccgggg ggctgcagaa cgcgcagttc gggatccgcc gcgacgggac cctggtcacc      540

gggtacctgt ctgaggagga ggtgctggac actgagaacc catttgtgca gctgctgagt      600

ggggtcgtgt ggctgattcg taatggaagc atctacatca acgagagcca agccacagag      660

tgtgacgaga cacaggagac aggttccttt agcaaatttg tgaatgtgat atcagccagg      720

acggccattg gccacgaccg gaaagggcag ctggtgctct ttcatgcaga cggccaaacg      780

gagcagcgtg gcatcaacct gtgggaaatg gcggagttcc tgctgaaaca ggacgtggtc      840

aacgccatca acctggatgg gggtggctct gccacctttg tgctcaacgg gaccttggcc      900

agttacccgt cagatcactg ccaggacaac atgtggcgct gtccccgcca agtgtccacc      960

gtggtgtgtg tgcacgaacc ccgctgccag ccgcctgact gccacggcca cgggacctgc     1020

gtggacgggc actgccaatg caccgggcac ttctggcggg gtcccggctg tgatgagctg     1080

gactgtggcc cctctaactg cagccagcac ggactgtgca cggagaccgg ctgccgctgt     1140

gatgccggat ggaccgggtc caactgcagt gaagagtgtc cccttggctg gcatgggccg     1200

ggctgccaga ggccttgtaa gtgtgagcac cattgtccct gtgaccccaa gactggcaac     1260

tgcagcgtct ccagagtaaa gcagtgtctc cagccacctg aagccaccct gagggcggga     1320

gaactctcct ttttcaccag gaccgcctgg ctagccctca ccctggcgct ggccttcctc     1380

ctgctgatca gcactgcagc aaacctgtcc ttgctcctgt ccagagcaga gaggaaccgg     1440

cgcctgcatg gggactatgc ataccacccg ctgcaggaga tgaacgggga gcctctggcc     1500

gcagagaagg agcagccagg gggcgcccac aaccccttca aggactga                  1548


<210>  170
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ala Thr Ser Thr Gly Arg Trp Leu Leu Leu Arg Leu Ala Leu Phe 
1               5                   10                  15      


Gly Phe Leu Trp Glu Ala Ser Gly Gly Leu Asp Ser Gly Ala Ser Arg 
            20                  25                  30          


Asp Asp Asp Leu Leu Leu Pro Tyr Pro Arg Ala Arg Ala Arg Leu Pro 
        35                  40                  45              


Arg Asp Cys Thr Arg Val Arg Ala Gly Asn Arg Glu His Glu Ser Trp 
    50                  55                  60                  


Pro Pro Pro Pro Ala Thr Pro Gly Ala Gly Gly Leu Ala Val Arg Thr 
65                  70                  75                  80  


Phe Val Ser His Phe Arg Asp Arg Ala Val Ala Gly His Leu Thr Arg 
                85                  90                  95      


Ala Val Glu Pro Leu Arg Thr Phe Ser Val Leu Glu Pro Gly Gly Pro 
            100                 105                 110         


Gly Gly Cys Ala Ala Arg Arg Arg Ala Thr Val Glu Glu Thr Ala Arg 
        115                 120                 125             


Ala Ala Asp Cys Arg Val Ala Gln Asn Gly Gly Phe Phe Arg Met Asn 
    130                 135                 140                 


Ser Gly Glu Cys Leu Gly Asn Val Val Ser Asp Glu Arg Arg Val Ser 
145                 150                 155                 160 


Ser Ser Gly Gly Leu Gln Asn Ala Gln Phe Gly Ile Arg Arg Asp Gly 
                165                 170                 175     


Thr Leu Val Thr Gly Tyr Leu Ser Glu Glu Glu Val Leu Asp Thr Glu 
            180                 185                 190         


Asn Pro Phe Val Gln Leu Leu Ser Gly Val Val Trp Leu Ile Arg Asn 
        195                 200                 205             


Gly Ser Ile Tyr Ile Asn Glu Ser Gln Ala Thr Glu Cys Asp Glu Thr 
    210                 215                 220                 


Gln Glu Thr Gly Ser Phe Ser Lys Phe Val Asn Val Ile Ser Ala Arg 
225                 230                 235                 240 


Thr Ala Ile Gly His Asp Arg Lys Gly Gln Leu Val Leu Phe His Ala 
                245                 250                 255     


Asp Gly Gln Thr Glu Gln Arg Gly Ile Asn Leu Trp Glu Met Ala Glu 
            260                 265                 270         


Phe Leu Leu Lys Gln Asp Val Val Asn Ala Ile Asn Leu Asp Gly Gly 
        275                 280                 285             


Gly Ser Ala Thr Phe Val Leu Asn Gly Thr Leu Ala Ser Tyr Pro Ser 
    290                 295                 300                 


Asp His Cys Gln Asp Asn Met Trp Arg Cys Pro Arg Gln Val Ser Thr 
305                 310                 315                 320 


Val Val Cys Val His Glu Pro Arg Cys Gln Pro Pro Asp Cys His Gly 
                325                 330                 335     


His Gly Thr Cys Val Asp Gly His Cys Gln Cys Thr Gly His Phe Trp 
            340                 345                 350         


Arg Gly Pro Gly Cys Asp Glu Leu Asp Cys Gly Pro Ser Asn Cys Ser 
        355                 360                 365             


Gln His Gly Leu Cys Thr Glu Thr Gly Cys Arg Cys Asp Ala Gly Trp 
    370                 375                 380                 


Thr Gly Ser Asn Cys Ser Glu Glu Cys Pro Leu Gly Trp His Gly Pro 
385                 390                 395                 400 


Gly Cys Gln Arg Pro Cys Lys Cys Glu His His Cys Pro Cys Asp Pro 
                405                 410                 415     


Lys Thr Gly Asn Cys Ser Val Ser Arg Val Lys Gln Cys Leu Gln Pro 
            420                 425                 430         


Pro Glu Ala Thr Leu Arg Ala Gly Glu Leu Ser Phe Phe Thr Arg Thr 
        435                 440                 445             


Ala Trp Leu Ala Leu Thr Leu Ala Leu Ala Phe Leu Leu Leu Ile Ser 
    450                 455                 460                 


Thr Ala Ala Asn Leu Ser Leu Leu Leu Ser Arg Ala Glu Arg Asn Arg 
465                 470                 475                 480 


Arg Leu His Gly Asp Tyr Ala Tyr His Pro Leu Gln Glu Met Asn Gly 
                485                 490                 495     


Glu Pro Leu Ala Ala Glu Lys Glu Gln Pro Gly Gly Ala His Asn Pro 
            500                 505                 510         


Phe Lys Asp 
        515 


<210>  171
<211>  1554
<212>  DNA
<213>  Mus musculus

<400>  171
atggcggcgc ccagggggcc cgggctgttc ctcatacccg cgctgctcgg cttactcggg       60

gtggcgtggt gcagcctaag cttcggggtt tcccgcgacg atgacctgct gctgccttac      120

ccactagcgc gcagacgtcc ctcgcgagac tgcgcccggg tgcgctcagg tagcccagag      180

caggagagct ggcctccgcc acccacgaac cccggcgcca gccaccacgc ggccgtgcgc      240

accttcgtgt cgcacttcga ggggcgcgcg gtggccggcc acctgacgcg ggtcgccgat      300

cccctacgca ctttctcggt gctggagccc ggaggagccg ggggctgcgc gcagaagcgc      360

cgcgctactg tggaggacac agccgtcccg gccggttgcc gcatcgctca gaacggtggc      420

ttcttccgca tgagcactgg cgagtgcttg gggaacgtgg tgagcgacgg gcggctggtg      480

agcagctcag ggggactgca gaacgcgcag ttcggtatcc gacgcgatgg aaccatagtc      540

accgggtacc tgtctgagga ggaggttctg gatcccgtga atccgttcgt gcagctgctg      600

agcggagtcg tgtggctcat ccgcaatgga aacatctaca tcaacgagag ccaagccatc      660

gagtgtgacg agacacagga gacaggttct tttagcaaat ttgtgaatgt gatgtcagcc      720

aggacagccg tgggtcatga ccgtgagggg cagcttatcc tcttccatgc tgatggacag      780

acggaacagc gtggccttaa cctatgggag atggcagagt tcctgcgtca acaagatgtc      840

gtcaatgcca tcaacctgga tggaggcggt tctgctactt ttgtgctcaa tgggaccctg      900

gccagttacc cttcagatca ctgccaggac aacatgtggc gctgtccccg ccaagtgtcc      960

actgtggtgt gtgtgcatga accgcgctgc cagccacccg actgcagtgg ccatgggacc     1020

tgtgtggatg gccactgtga atgcaccagc cacttctggc ggggcgaggc ctgcagcgag     1080

ctggactgtg gcccctccaa ctgcagccag catgggctgt gcacagagac tggctgccac     1140

tgtgatgctg ggtggacagg atccaactgc agtgaagagt gtcctctggg ctggtatggg     1200

ccaggttgcc agaggccctg ccagtgtgag caccagtgtt cctgtgaccc gcagactggc     1260

aactgcagca tctcccaagt gaggcagtgt ctccagccaa ctgaggctac gccgagggca     1320

ggagagctgg cctctttcac caggaccacc tggctagccc tcaccctgac actaattttc     1380

ctgctgctga tcagcactgg ggtcaacgtg tccttgttcc tgggctccag ggccgagagg     1440

aaccggcacc tcgacgggga ctatgtgtat cacccactgc aggaggtgaa cggggaagcg     1500

ctgactgcag agaaggagca catggaggaa actagcaacc ccttcaagga ctga           1554


<210>  172
<211>  517
<212>  PRT
<213>  Mus musculus

<400>  172

Met Ala Ala Pro Arg Gly Pro Gly Leu Phe Leu Ile Pro Ala Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Val Ala Trp Cys Ser Leu Ser Phe Gly Val Ser Arg 
            20                  25                  30          


Asp Asp Asp Leu Leu Leu Pro Tyr Pro Leu Ala Arg Arg Arg Pro Ser 
        35                  40                  45              


Arg Asp Cys Ala Arg Val Arg Ser Gly Ser Pro Glu Gln Glu Ser Trp 
    50                  55                  60                  


Pro Pro Pro Pro Thr Asn Pro Gly Ala Ser His His Ala Ala Val Arg 
65                  70                  75                  80  


Thr Phe Val Ser His Phe Glu Gly Arg Ala Val Ala Gly His Leu Thr 
                85                  90                  95      


Arg Val Ala Asp Pro Leu Arg Thr Phe Ser Val Leu Glu Pro Gly Gly 
            100                 105                 110         


Ala Gly Gly Cys Ala Gln Lys Arg Arg Ala Thr Val Glu Asp Thr Ala 
        115                 120                 125             


Val Pro Ala Gly Cys Arg Ile Ala Gln Asn Gly Gly Phe Phe Arg Met 
    130                 135                 140                 


Ser Thr Gly Glu Cys Leu Gly Asn Val Val Ser Asp Gly Arg Leu Val 
145                 150                 155                 160 


Ser Ser Ser Gly Gly Leu Gln Asn Ala Gln Phe Gly Ile Arg Arg Asp 
                165                 170                 175     


Gly Thr Ile Val Thr Gly Tyr Leu Ser Glu Glu Glu Val Leu Asp Pro 
            180                 185                 190         


Val Asn Pro Phe Val Gln Leu Leu Ser Gly Val Val Trp Leu Ile Arg 
        195                 200                 205             


Asn Gly Asn Ile Tyr Ile Asn Glu Ser Gln Ala Ile Glu Cys Asp Glu 
    210                 215                 220                 


Thr Gln Glu Thr Gly Ser Phe Ser Lys Phe Val Asn Val Met Ser Ala 
225                 230                 235                 240 


Arg Thr Ala Val Gly His Asp Arg Glu Gly Gln Leu Ile Leu Phe His 
                245                 250                 255     


Ala Asp Gly Gln Thr Glu Gln Arg Gly Leu Asn Leu Trp Glu Met Ala 
            260                 265                 270         


Glu Phe Leu Arg Gln Gln Asp Val Val Asn Ala Ile Asn Leu Asp Gly 
        275                 280                 285             


Gly Gly Ser Ala Thr Phe Val Leu Asn Gly Thr Leu Ala Ser Tyr Pro 
    290                 295                 300                 


Ser Asp His Cys Gln Asp Asn Met Trp Arg Cys Pro Arg Gln Val Ser 
305                 310                 315                 320 


Thr Val Val Cys Val His Glu Pro Arg Cys Gln Pro Pro Asp Cys Ser 
                325                 330                 335     


Gly His Gly Thr Cys Val Asp Gly His Cys Glu Cys Thr Ser His Phe 
            340                 345                 350         


Trp Arg Gly Glu Ala Cys Ser Glu Leu Asp Cys Gly Pro Ser Asn Cys 
        355                 360                 365             


Ser Gln His Gly Leu Cys Thr Glu Thr Gly Cys His Cys Asp Ala Gly 
    370                 375                 380                 


Trp Thr Gly Ser Asn Cys Ser Glu Glu Cys Pro Leu Gly Trp Tyr Gly 
385                 390                 395                 400 


Pro Gly Cys Gln Arg Pro Cys Gln Cys Glu His Gln Cys Ser Cys Asp 
                405                 410                 415     


Pro Gln Thr Gly Asn Cys Ser Ile Ser Gln Val Arg Gln Cys Leu Gln 
            420                 425                 430         


Pro Thr Glu Ala Thr Pro Arg Ala Gly Glu Leu Ala Ser Phe Thr Arg 
        435                 440                 445             


Thr Thr Trp Leu Ala Leu Thr Leu Thr Leu Ile Phe Leu Leu Leu Ile 
    450                 455                 460                 


Ser Thr Gly Val Asn Val Ser Leu Phe Leu Gly Ser Arg Ala Glu Arg 
465                 470                 475                 480 


Asn Arg His Leu Asp Gly Asp Tyr Val Tyr His Pro Leu Gln Glu Val 
                485                 490                 495     


Asn Gly Glu Ala Leu Thr Ala Glu Lys Glu His Met Glu Glu Thr Ser 
            500                 505                 510         


Asn Pro Phe Lys Asp 
        515         


<210>  173
<211>  2364
<212>  DNA
<213>  Homo sapiens

<400>  173
atggagcctg caggggagcg ctttcccgaa caaaggcaag tcctgattct ccttctttta       60

ctggaagtga ctctggcagg ctgggaaccc cgtcgctatt ctgtgatgga ggaaacagag      120

agaggttctt ttgtagccaa cctggccaat gacctagggc tgggagtggg ggagctagcc      180

gagcggggag cccgggtagt ttctgaggat aacgaacaag gcttgcagct tgatctgcag      240

accgggcagt tgatattaaa tgagaagctg gaccgggaga agctgtgtgg ccctactgag      300

ccctgtataa tgcatttcca agtgttactg aaaaaacctt tggaagtatt tcgagctgaa      360

ctactagtga cagacataaa cgatcattct cctgagtttc ctgaaagaga aatgaccctg      420

aaaatcccag aaactagctc ccttgggact gtgtttcctc tgaaaaaagc tcgggacttg      480

gacgtgggca gcaataatgt tcaaaactac aatatttctc ccaattctca tttccatgtt      540

tccactcgca cccgagggga tggcaggaaa tacccagagc tggtgctgga cacagaactg      600

gatcgcgagg agcaggccga gctcagatta accttgacag cggtggacgg tggctctcca      660

ccccgatctg gcaccgtcca gatcctcatc ttggtcttgg acgccaatga caatgccccg      720

gagtttgtgc aggcgctcta cgaggtgcag gtcccagaga acagcccagt aggctcccta      780

gttgtcaagg tctctgctag ggatttagac actgggacaa atggagagat atcatactcc      840

ctttattaca gctctcagga gatagacaaa ccttttgagc taagcagcct ttcaggagaa      900

attcgactaa ttaaaaaact agattttgag acaatgtctt cgtatgatct agatatagag      960

gcatctgatg gcgggggact ttctggaaaa tgctctgtct ctgttaaggt gctggatgtt     1020

aacgataact tcccggaact aagtatttca tcacttacca gccctattcc cgagaattct     1080

ccagagacag aagtggccct gtttaggatt agagaccgag actctgggga aaatggaaaa     1140

atgatttgct caattcagga tgatgttcct tttaagctaa aaccttctgt tgagaatttc     1200

tacaggctgg taacagaagg ggcgctggac agagagacca gagccgagta caacatcacc     1260

atcaccatca cagacttggg gactccaagg ctgaaaaccg agcagagcat aaccgtgctg     1320

gtgtcggacg tcaatgacaa cgcccccgcc ttcacccaaa cctcctacac cctgttcgtc     1380

cgcgagaaca acagccccgc cctgcacatc ggcagtgtca gcgccacaga cagagactcg     1440

ggcaccaacg cccaggtcac ctactcgctg ctgccgcccc gggacccgca cctgcccctc     1500

acctccctgg tctccattaa cacggacaac ggccacctgt tcgctctcca gtcgctggac     1560

tacgaggccc tgcaggcttt cgagttccgc gtgggcgcca cagaccgcgg cttcccggcg     1620

ctgagcagcg aggcgctggt gcgagtgctg gtgctggacg ccaacgacaa ctcgcccttc     1680

gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg agctggtgcc ccgggcggcc     1740

gagccgggct acctggtgac caaggtggtg gcggtggacg gcgactcggg ccagaacgcc     1800

tggctgtcgt accagctgct caaggccacg gagcccgggc tgttcggcgt gtgggcgcac     1860

aatggcgagg tgcgcaccgc caggctgctg agcgagcgcg acgtggccaa gcacaggcta     1920

gtggtgctgg tcaaggacaa tggcgagcct ccgcgctcgg ccaccgccac gctgcaagtg     1980

ctcctggtgg acggcttctc tcagccctac ctgccgctcc cagaggcggc cccggcccaa     2040

gcccaggccg actcgcttac cgtctacctg gtggtggcat tggcctcggt gtcttcgctc     2100

ttcctcttct cggtgttcct gttcgtggca gtgcggctgt gcaggaggag cagggcggcc     2160

tcagtgggtc gctgctcggt gcccgagggc ccctttccag ggcatctggt ggacgtgagc     2220

ggcaccggga ccctttccca gagctaccag tacgaggtgt gtctgacggg aggctctgaa     2280

agtaatgatt tcaagttctt gaagcctata ttcccaaata ttgtaagcca ggactctagg     2340

aggaaatcag aatttctaga ataa                                            2364


<210>  174
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Glu Pro Ala Gly Glu Arg Phe Pro Glu Gln Arg Gln Val Leu Ile 
1               5                   10                  15      


Leu Leu Leu Leu Leu Glu Val Thr Leu Ala Gly Trp Glu Pro Arg Arg 
            20                  25                  30          


Tyr Ser Val Met Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Asn Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Glu Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Glu Asp Asn Glu Gln Gly Leu Gln Leu Asp Leu Gln 
65                  70                  75                  80  


Thr Gly Gln Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Met His Phe Gln Val Leu Leu Lys Lys 
            100                 105                 110         


Pro Leu Glu Val Phe Arg Ala Glu Leu Leu Val Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Glu Phe Pro Glu Arg Glu Met Thr Leu Lys Ile Pro Glu 
    130                 135                 140                 


Thr Ser Ser Leu Gly Thr Val Phe Pro Leu Lys Lys Ala Arg Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Asn Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ser Thr Arg Thr Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Thr Glu Leu Asp Arg Glu Glu Gln Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Val Gln Ala Leu Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Val Gly Ser Leu Val Val Lys Val Ser Ala Arg Asp Leu Asp Thr Gly 
            260                 265                 270         


Thr Asn Gly Glu Ile Ser Tyr Ser Leu Tyr Tyr Ser Ser Gln Glu Ile 
        275                 280                 285             


Asp Lys Pro Phe Glu Leu Ser Ser Leu Ser Gly Glu Ile Arg Leu Ile 
    290                 295                 300                 


Lys Lys Leu Asp Phe Glu Thr Met Ser Ser Tyr Asp Leu Asp Ile Glu 
305                 310                 315                 320 


Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Val Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Phe Pro Glu Leu Ser Ile Ser Ser Leu 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asp Val Pro Phe Lys Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Arg Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Thr Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Gln Ser Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Arg Asp Pro 
                485                 490                 495     


His Leu Pro Leu Thr Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Phe Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Val Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Phe Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Ser Asn Asp Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Phe Pro Asn Ile Val Ser Gln Asp Ser Arg Arg Lys Ser Glu 
    770                 775                 780                 


Phe Leu Glu 
785         


<210>  175
<211>  2385
<212>  DNA
<213>  Mus musculus

<400>  175
atgaagattg gaagggaaca cagaaaaagg caagttctgt tgatctttct cttgctggga       60

gtggttgggg cgggctcgga accccgccgc tactttgtga tggaggaaac acccagtggc      120

actgttttgg cagatctagt ccaggaccta gggctgggag ttgcggagct agctgctcga      180

ggagcccagg tagtctctga ggaaaaggaa tcccgcttgc agctggatct acagactggg      240

aagctaatct taaatgaaaa actggaccgc gaggagctgt gcggctccac tgagccctgt      300

gtcactcatt tccaagtgtt actgaaaaaa ccactggaaa tatttcaagc tgagctacga      360

gtaggagaca ttaatgatca ttctcctgag tttcctgaaa gagaaatggc cgtgaaaatc      420

atagagaata gccctgttgg cactgcgttt ctactcaaaa cagctcagga tttggatgtg      480

ggaaataaca gcgttcagaa ctataagatt ggtaccaatt ctcatttcca tgtttccatc      540

cgcaaccgag gtgatggaag aaaataccca gagctggtgc tggacaagga gctcgatcgc      600

gaggtgcagg cagcgttcag attaactctg acagcgctag atggcggttc tccgcccagg      660

actggcacct cgcaaatccg cattgttgtc ttggatgtca atgacaatgc ccctgagttt      720

gcacaggctt tctaccgggt gcaaattcca gagaacagtc cctcgggttc catggttgct      780

aaggtctctg ctaaggattt agacactggg acaaatggag aggtatcata ctctcttttt      840

cacagttctc aggaaatgag caaaactttt gagctaaacg ccctgtcagg agaagttcga      900

ctaatcaaaa cactggactt tgagacaaca ccttcatatg aactagacat agaggcaact      960

gatggcgggg gtctttctgg aaaatgctct gtttctattc aggtggtgga tgtcaacgat     1020

aattacccag aactaattat atcatcgctc accaatccaa tcccagaaaa ttcaccagag     1080

acagaggtgg ctctgtttcg gattcgagac cgagactctg gagagaatgg aaggacaatt     1140

tgttccatcc aggatggtgt tccctttaca ctggaacctt ccgttgagaa cttctataga     1200

ctggtgacag atggagctct ggacagagag atcagagctg agtacaacat tactatctcc     1260

gtcaccgacc tgggcatacc caagctcaca acccagcaca ccataacagt gcaggtgtcc     1320

gacatcaacg acaatgcccc cgcctttacc caagtctcct acaccatgct cgtccacgag     1380

aacaacagcc cagccctgca cataggcacc atcagcgcca cagactcaga ctcaggctcc     1440

aatgcccaca tcacctactc gttgctgccg gcccaggagc cacagctggc cctcaactca     1500

ctcatctcca tcaacgctga caacgggcag ctgttcgcgc tcagggcgct ggactacgag     1560

gccctgcagg ccttcgagtt ccacgtgagt gccacagacc gaggctcacc agcgctcagc     1620

agccaggctc tggtgcgcat agtggtgctg gacgacaatg acaatgcgcc cttcgtgctc     1680

tacccgatgc agaatgcctc tgcgccctgc acagagctgc tgcccagggc ggcagagccc     1740

ggctacctgg tcaccaaggt ggtggctgtg gatcgcgact ctggccagaa tgcctggctg     1800

tcgttccagc tgctcaaggc tacagagccc gggttgttca gcgtgtgggc gcacaatggt     1860

gaggtgcgca ccaccaggct gttgagtgag cgagatgtac ccaagcacag gctgctgctg     1920

gtggtcaagg acaatggaga gcctccgcgc tctgctagcg tcacactgca ggtgctaatg     1980

gtggatggct tctctcagcc ctacctgcct ctgccagagg tggtgcgcga ccccagtcac     2040

caggaaggtg atgtgctcac gctgtacctg gtcatagcct tggcttctgt gtcttctctc     2100

ttcctcttgt ctgtgctgct gtttgtgggg gtgaggctgt gcaggagggc cagggaggtc     2160

tctctgggtg gctgctctgt gcctgaggga cactttcctg gccacctggt ggatgtcagc     2220

ggggcaggga ccctgtctca gagctaccag tatgaggtgt gtcttacagg agattctcag     2280

agtaatgagt tcaaattctt gaagcctgtg ttttctggta ttgtagacca aaactatggt     2340

aggcaaccag atgatcagtc cttctcaagt gttttaggta tgtga                     2385


<210>  176
<211>  794
<212>  PRT
<213>  Mus musculus

<400>  176

Met Lys Ile Gly Arg Glu His Arg Lys Arg Gln Val Leu Leu Ile Phe 
1               5                   10                  15      


Leu Leu Leu Gly Val Val Gly Ala Gly Ser Glu Pro Arg Arg Tyr Phe 
            20                  25                  30          


Val Met Glu Glu Thr Pro Ser Gly Thr Val Leu Ala Asp Leu Val Gln 
        35                  40                  45              


Asp Leu Gly Leu Gly Val Ala Glu Leu Ala Ala Arg Gly Ala Gln Val 
    50                  55                  60                  


Val Ser Glu Glu Lys Glu Ser Arg Leu Gln Leu Asp Leu Gln Thr Gly 
65                  70                  75                  80  


Lys Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys Gly Ser 
                85                  90                  95      


Thr Glu Pro Cys Val Thr His Phe Gln Val Leu Leu Lys Lys Pro Leu 
            100                 105                 110         


Glu Ile Phe Gln Ala Glu Leu Arg Val Gly Asp Ile Asn Asp His Ser 
        115                 120                 125             


Pro Glu Phe Pro Glu Arg Glu Met Ala Val Lys Ile Ile Glu Asn Ser 
    130                 135                 140                 


Pro Val Gly Thr Ala Phe Leu Leu Lys Thr Ala Gln Asp Leu Asp Val 
145                 150                 155                 160 


Gly Asn Asn Ser Val Gln Asn Tyr Lys Ile Gly Thr Asn Ser His Phe 
                165                 170                 175     


His Val Ser Ile Arg Asn Arg Gly Asp Gly Arg Lys Tyr Pro Glu Leu 
            180                 185                 190         


Val Leu Asp Lys Glu Leu Asp Arg Glu Val Gln Ala Ala Phe Arg Leu 
        195                 200                 205             


Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Thr Gly Thr Ser 
    210                 215                 220                 


Gln Ile Arg Ile Val Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe 
225                 230                 235                 240 


Ala Gln Ala Phe Tyr Arg Val Gln Ile Pro Glu Asn Ser Pro Ser Gly 
                245                 250                 255     


Ser Met Val Ala Lys Val Ser Ala Lys Asp Leu Asp Thr Gly Thr Asn 
            260                 265                 270         


Gly Glu Val Ser Tyr Ser Leu Phe His Ser Ser Gln Glu Met Ser Lys 
        275                 280                 285             


Thr Phe Glu Leu Asn Ala Leu Ser Gly Glu Val Arg Leu Ile Lys Thr 
    290                 295                 300                 


Leu Asp Phe Glu Thr Thr Pro Ser Tyr Glu Leu Asp Ile Glu Ala Thr 
305                 310                 315                 320 


Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Ile Gln Val Val 
                325                 330                 335     


Asp Val Asn Asp Asn Tyr Pro Glu Leu Ile Ile Ser Ser Leu Thr Asn 
            340                 345                 350         


Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu Phe Arg Ile 
        355                 360                 365             


Arg Asp Arg Asp Ser Gly Glu Asn Gly Arg Thr Ile Cys Ser Ile Gln 
    370                 375                 380                 


Asp Gly Val Pro Phe Thr Leu Glu Pro Ser Val Glu Asn Phe Tyr Arg 
385                 390                 395                 400 


Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Ile Arg Ala Glu Tyr Asn 
                405                 410                 415     


Ile Thr Ile Ser Val Thr Asp Leu Gly Ile Pro Lys Leu Thr Thr Gln 
            420                 425                 430         


His Thr Ile Thr Val Gln Val Ser Asp Ile Asn Asp Asn Ala Pro Ala 
        435                 440                 445             


Phe Thr Gln Val Ser Tyr Thr Met Leu Val His Glu Asn Asn Ser Pro 
    450                 455                 460                 


Ala Leu His Ile Gly Thr Ile Ser Ala Thr Asp Ser Asp Ser Gly Ser 
465                 470                 475                 480 


Asn Ala His Ile Thr Tyr Ser Leu Leu Pro Ala Gln Glu Pro Gln Leu 
                485                 490                 495     


Ala Leu Asn Ser Leu Ile Ser Ile Asn Ala Asp Asn Gly Gln Leu Phe 
            500                 505                 510         


Ala Leu Arg Ala Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe His 
        515                 520                 525             


Val Ser Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Gln Ala Leu 
    530                 535                 540                 


Val Arg Ile Val Val Leu Asp Asp Asn Asp Asn Ala Pro Phe Val Leu 
545                 550                 555                 560 


Tyr Pro Met Gln Asn Ala Ser Ala Pro Cys Thr Glu Leu Leu Pro Arg 
                565                 570                 575     


Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Arg 
            580                 585                 590         


Asp Ser Gly Gln Asn Ala Trp Leu Ser Phe Gln Leu Leu Lys Ala Thr 
        595                 600                 605             


Glu Pro Gly Leu Phe Ser Val Trp Ala His Asn Gly Glu Val Arg Thr 
    610                 615                 620                 


Thr Arg Leu Leu Ser Glu Arg Asp Val Pro Lys His Arg Leu Leu Leu 
625                 630                 635                 640 


Val Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Ser Val Thr Leu 
                645                 650                 655     


Gln Val Leu Met Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu Pro 
            660                 665                 670         


Glu Val Val Arg Asp Pro Ser His Gln Glu Gly Asp Val Leu Thr Leu 
        675                 680                 685             


Tyr Leu Val Ile Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Leu Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Gly Val Arg Leu Cys Arg Arg Ala Arg Glu Val 
705                 710                 715                 720 


Ser Leu Gly Gly Cys Ser Val Pro Glu Gly His Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Ala Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Asp Ser Gln Ser Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Val Phe Ser Gly Ile Val Asp Gln Asn Tyr Gly Arg Gln Pro Asp 
    770                 775                 780                 


Asp Gln Ser Phe Ser Ser Val Leu Gly Met 
785                 790                 


<210>  177
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  177
atggccacgg agttacagtg tccggactcc atgccctgtc acaaccagca agtaaactct       60

gcctcaaccc caagtcccga gcagctgcga cctggcgatc tgatcctgga ccacgcaggg      120

ggaaacagag cctccagggc caaggtgatt ctcctcacgg ggtacgccca ttctagcctg      180

ccggccgagc tggactctgg ggcctgcggc ggctccagcc tcaactcaga gggcaacagt      240

ggtagtggtg acagtagcag ctatgacgca ccagctggca actccttcct agaggactgc      300

gaactctccc ggcagatcgg ggcgcagctt aagctgctgc ctatgaatga tcagatacgg      360

gagctacaga ccatcatccg tgacaagaca gccagtagag gtgacttcat gttttctgcg      420

gatcgtttga tcagacttgt tgtggaagag ggattgaatc agctgccata taaagaatgc      480

atggtgacca ctccaacagg gtacaagtat gaaggagtga aatttgagaa gggaaattgt      540

ggggtcagca taatgagaag cggtgaggca atggaacaag gtttacgaga ctgctgtcga      600

tccatacgaa ttggaaagat cctgattcag agtgatgagg agacacaaag agccaaagta      660

tattatgcca aattcccccc agacatttac cggagaaaag tccttctgat gtatccaatt      720

ctcagcactg gaaatactgt aattgaagct gtaaaggttc ttatagaaca tggagttcaa      780

cccagtgtta tcatcctact cagtctgttc tccactcctc atggtgccaa atcaatcatt      840

caggagtttc cagagatcac aattttaact actgaagttc atcctgttgc acctacacat      900

tttggacaga aatactttgg aacagactaa                                       930


<210>  178
<211>  846
<212>  DNA
<213>  Homo sapiens

<400>  178
atggccacgg agttacagtg tccggactcc atgccctgtc acaaccagca agtaaactct       60

gcctcaaccc caagtcccga gcagctgcga cctggcgatc tgatcctgga ccacgcaggg      120

ggaaacagag cctccagggc caaggtgatt ctcctcacgg ggtacgccca ttctagcctg      180

ccggccgagc tggactctgg ggcctgcggc ggctccagcc tcaactcaga gggcaacagt      240

ggtagtggtg acagtagcag ctatgacgca ccagctggca actccttcct agaggactgc      300

gaactctccc ggcagatcgg ggcgcagctt aagctgctgc ctatgaatga tcagatacgg      360

gagctacaga ccatcatccg tgacaagaca gccagtagag gtgacttcat gttttctgcg      420

gatcgtttga tcagacttgt tgtggaagag ggattgaatc agctgccata taaagaatgc      480

atggtgacca ctccaacagg gtacaagtat gaaggagtga aatttgagaa gggaaattgt      540

ggggtcagca taatgagaag cggtgaggca atggaacaag gtttacgaga ctgctgtcga      600

tccatacgaa ttggaaagat cctgattcag agtgatgagg agacacaaag agccaaagta      660

tattatgcca aattcccccc agacatttac cggagaaaag tccttctgat gtatccaatt      720

ctcagcactg gaaatactgt aattgaagct gtaaaggttc ttatagaaca tggagttcaa      780

cccagtgtta tcatcctact cagtctgttc tccactcctc atggtgagtt cagcatgagg      840

cagtaa                                                                 846


<210>  179
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ala Thr Glu Leu Gln Cys Pro Asp Ser Met Pro Cys His Asn Gln 
1               5                   10                  15      


Gln Val Asn Ser Ala Ser Thr Pro Ser Pro Glu Gln Leu Arg Pro Gly 
            20                  25                  30          


Asp Leu Ile Leu Asp His Ala Gly Gly Asn Arg Ala Ser Arg Ala Lys 
        35                  40                  45              


Val Ile Leu Leu Thr Gly Tyr Ala His Ser Ser Leu Pro Ala Glu Leu 
    50                  55                  60                  


Asp Ser Gly Ala Cys Gly Gly Ser Ser Leu Asn Ser Glu Gly Asn Ser 
65                  70                  75                  80  


Gly Ser Gly Asp Ser Ser Ser Tyr Asp Ala Pro Ala Gly Asn Ser Phe 
                85                  90                  95      


Leu Glu Asp Cys Glu Leu Ser Arg Gln Ile Gly Ala Gln Leu Lys Leu 
            100                 105                 110         


Leu Pro Met Asn Asp Gln Ile Arg Glu Leu Gln Thr Ile Ile Arg Asp 
        115                 120                 125             


Lys Thr Ala Ser Arg Gly Asp Phe Met Phe Ser Ala Asp Arg Leu Ile 
    130                 135                 140                 


Arg Leu Val Val Glu Glu Gly Leu Asn Gln Leu Pro Tyr Lys Glu Cys 
145                 150                 155                 160 


Met Val Thr Thr Pro Thr Gly Tyr Lys Tyr Glu Gly Val Lys Phe Glu 
                165                 170                 175     


Lys Gly Asn Cys Gly Val Ser Ile Met Arg Ser Gly Glu Ala Met Glu 
            180                 185                 190         


Gln Gly Leu Arg Asp Cys Cys Arg Ser Ile Arg Ile Gly Lys Ile Leu 
        195                 200                 205             


Ile Gln Ser Asp Glu Glu Thr Gln Arg Ala Lys Val Tyr Tyr Ala Lys 
    210                 215                 220                 


Phe Pro Pro Asp Ile Tyr Arg Arg Lys Val Leu Leu Met Tyr Pro Ile 
225                 230                 235                 240 


Leu Ser Thr Gly Asn Thr Val Ile Glu Ala Val Lys Val Leu Ile Glu 
                245                 250                 255     


His Gly Val Gln Pro Ser Val Ile Ile Leu Leu Ser Leu Phe Ser Thr 
            260                 265                 270         


Pro His Gly Ala Lys Ser Ile Ile Gln Glu Phe Pro Glu Ile Thr Ile 
        275                 280                 285             


Leu Thr Thr Glu Val His Pro Val Ala Pro Thr His Phe Gly Gln Lys 
    290                 295                 300                 


Tyr Phe Gly Thr Asp 
305                 


<210>  180
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Ala Thr Glu Leu Gln Cys Pro Asp Ser Met Pro Cys His Asn Gln 
1               5                   10                  15      


Gln Val Asn Ser Ala Ser Thr Pro Ser Pro Glu Gln Leu Arg Pro Gly 
            20                  25                  30          


Asp Leu Ile Leu Asp His Ala Gly Gly Asn Arg Ala Ser Arg Ala Lys 
        35                  40                  45              


Val Ile Leu Leu Thr Gly Tyr Ala His Ser Ser Leu Pro Ala Glu Leu 
    50                  55                  60                  


Asp Ser Gly Ala Cys Gly Gly Ser Ser Leu Asn Ser Glu Gly Asn Ser 
65                  70                  75                  80  


Gly Ser Gly Asp Ser Ser Ser Tyr Asp Ala Pro Ala Gly Asn Ser Phe 
                85                  90                  95      


Leu Glu Asp Cys Glu Leu Ser Arg Gln Ile Gly Ala Gln Leu Lys Leu 
            100                 105                 110         


Leu Pro Met Asn Asp Gln Ile Arg Glu Leu Gln Thr Ile Ile Arg Asp 
        115                 120                 125             


Lys Thr Ala Ser Arg Gly Asp Phe Met Phe Ser Ala Asp Arg Leu Ile 
    130                 135                 140                 


Arg Leu Val Val Glu Glu Gly Leu Asn Gln Leu Pro Tyr Lys Glu Cys 
145                 150                 155                 160 


Met Val Thr Thr Pro Thr Gly Tyr Lys Tyr Glu Gly Val Lys Phe Glu 
                165                 170                 175     


Lys Gly Asn Cys Gly Val Ser Ile Met Arg Ser Gly Glu Ala Met Glu 
            180                 185                 190         


Gln Gly Leu Arg Asp Cys Cys Arg Ser Ile Arg Ile Gly Lys Ile Leu 
        195                 200                 205             


Ile Gln Ser Asp Glu Glu Thr Gln Arg Ala Lys Val Tyr Tyr Ala Lys 
    210                 215                 220                 


Phe Pro Pro Asp Ile Tyr Arg Arg Lys Val Leu Leu Met Tyr Pro Ile 
225                 230                 235                 240 


Leu Ser Thr Gly Asn Thr Val Ile Glu Ala Val Lys Val Leu Ile Glu 
                245                 250                 255     


His Gly Val Gln Pro Ser Val Ile Ile Leu Leu Ser Leu Phe Ser Thr 
            260                 265                 270         


Pro His Gly Glu Phe Ser Met Arg Gln 
        275                 280     


<210>  181
<211>  933
<212>  DNA
<213>  Mus musculus

<400>  181
atggcctcgg agttacagcg tccggactcc atgccctgtc acaatcggca agtaaactct       60

acttctagcc caagtcccga gcatctgcta gccgaggacc gggtcctgga tcatgcagag      120

gaaaataacg ctgctatggc taagctgact ctcctccctg ggcacgccca ttctagcgtg      180

ctttcggagc gggactctcc ggcctgctgc agcactaatc ttcactctga gaaccacagt      240

gacagtagtg acagtggcaa ctacgatgca cctgtcggcg gcgactccct gctaggggac      300

tgtgaactct cccgacagat tggggctcag cttaagttgc tgcctatgaa tgatcagatc      360

cgggagcttc agactatcat ccgggacaag acagccagta gaggggactt catgttttct      420

gcagatcgct tgatcagact tgttgtagaa gagggactga atcagctgcc atataaagaa      480

tgtatggtga ccactccgac agggcacaag tatgaaggag tgaaatttga gaaaggaaat      540

tgtggggtca gcataatgag aagtggtgag gcaatggaac aaggtttgcg agactgctgt      600

cgatccatac ggattgggaa gatcctgatt cagagtgatg aggagacaca aagggccaaa      660

gtatattatg ccaagttccc cccagacatt catcgcagaa aagtccttct gatgtatcca      720

attctcagta ctggaaatac tgtaattgaa gctgtaaagg ttcttataga acatggtgtt      780

caacccagtg ttattatcct actcagtctc ttctccaccc cacatggtgc caaatcaatc      840

attcaagaat ttccagagat cacaatttta actacagaag tccatcctgt tgcacctaca      900

cattttggac agaaatactt tggaacagac taa                                   933


<210>  182
<211>  310
<212>  PRT
<213>  Mus musculus

<400>  182

Met Ala Ser Glu Leu Gln Arg Pro Asp Ser Met Pro Cys His Asn Arg 
1               5                   10                  15      


Gln Val Asn Ser Thr Ser Ser Pro Ser Pro Glu His Leu Leu Ala Glu 
            20                  25                  30          


Asp Arg Val Leu Asp His Ala Glu Glu Asn Asn Ala Ala Met Ala Lys 
        35                  40                  45              


Leu Thr Leu Leu Pro Gly His Ala His Ser Ser Val Leu Ser Glu Arg 
    50                  55                  60                  


Asp Ser Pro Ala Cys Cys Ser Thr Asn Leu His Ser Glu Asn His Ser 
65                  70                  75                  80  


Asp Ser Ser Asp Ser Gly Asn Tyr Asp Ala Pro Val Gly Gly Asp Ser 
                85                  90                  95      


Leu Leu Gly Asp Cys Glu Leu Ser Arg Gln Ile Gly Ala Gln Leu Lys 
            100                 105                 110         


Leu Leu Pro Met Asn Asp Gln Ile Arg Glu Leu Gln Thr Ile Ile Arg 
        115                 120                 125             


Asp Lys Thr Ala Ser Arg Gly Asp Phe Met Phe Ser Ala Asp Arg Leu 
    130                 135                 140                 


Ile Arg Leu Val Val Glu Glu Gly Leu Asn Gln Leu Pro Tyr Lys Glu 
145                 150                 155                 160 


Cys Met Val Thr Thr Pro Thr Gly His Lys Tyr Glu Gly Val Lys Phe 
                165                 170                 175     


Glu Lys Gly Asn Cys Gly Val Ser Ile Met Arg Ser Gly Glu Ala Met 
            180                 185                 190         


Glu Gln Gly Leu Arg Asp Cys Cys Arg Ser Ile Arg Ile Gly Lys Ile 
        195                 200                 205             


Leu Ile Gln Ser Asp Glu Glu Thr Gln Arg Ala Lys Val Tyr Tyr Ala 
    210                 215                 220                 


Lys Phe Pro Pro Asp Ile His Arg Arg Lys Val Leu Leu Met Tyr Pro 
225                 230                 235                 240 


Ile Leu Ser Thr Gly Asn Thr Val Ile Glu Ala Val Lys Val Leu Ile 
                245                 250                 255     


Glu His Gly Val Gln Pro Ser Val Ile Ile Leu Leu Ser Leu Phe Ser 
            260                 265                 270         


Thr Pro His Gly Ala Lys Ser Ile Ile Gln Glu Phe Pro Glu Ile Thr 
        275                 280                 285             


Ile Leu Thr Thr Glu Val His Pro Val Ala Pro Thr His Phe Gly Gln 
    290                 295                 300                 


Lys Tyr Phe Gly Thr Asp 
305                 310 


<210>  183
<211>  2817
<212>  DNA
<213>  Homo sapiens

<400>  183
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg      600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc      660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg      720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc      780

tacgccccag acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac      840

atcagcgacg ccgtgggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac      900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc      960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc     1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag     1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc     1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt     1200

gtgacgatcc accaggagcc cttcgtgtac gtcaagccca cgctgagtga tgggacatgc     1260

aaggaggagt tcacagtcaa cggcgaccca gtcaagaagg tgatctgcac cgggcccaac     1320

gacacgtcgc cgggcagccc ccgccacacg gtgcctcagt gttgctacgg cttttgcatc     1380

gacctgctca tcaagctggc acggaccatg aacttcacct acgaggtgca cctggtggca     1440

gatggcaagt tcggcacaca ggagcgggtg aacaacagca acaagaagga gtggaatggg     1500

atgatgggcg agctgctcag cgggcaggca gacatgatcg tggcgccgct aaccataaac     1560

aacgagcgcg cgcagtacat cgagttttcc aagcccttca agtaccaggg cctgactatt     1620

ctggtcaaga aggagattcc ccggagcacg ctggactcgt tcatgcagcc gttccagagc     1680

acactgtggc tgctggtggg gctgtcggtg cacgtggtgg ccgtgatgct gtacctgctg     1740

gaccgcttca gccccttcgg ccggttcaag gtgaacagcg aggaggagga ggaggacgca     1800

ctgaccctgt cctcggccat gtggttctcc tggggcgtcc tgctcaactc cggcatcggg     1860

gaaggcgccc ccagaagctt ctcagcgcgc atcctgggca tggtgtgggc cggctttgcc     1920

atgatcatcg tggcctccta caccgccaac ctggcggcct tcctggtgct ggaccggccg     1980

gaggagcgca tcacgggcat caacgaccct cggctgagga acccctcgga caagtttatc     2040

tacgccacgg tgaagcagag ctccgtggat atctacttcc ggcgccaggt ggagctgagc     2100

accatgtacc ggcatatgga gaagcacaac tacgagagtg cggcggaggc catccaggcc     2160

gtgagagaca acaagctgca tgccttcatc tgggactcgg cggtgctgga gttcgaggcc     2220

tcgcagaagt gcgacctggt gacgactgga gagctgtttt tccgctcggg cttcggcata     2280

ggcatgcgca aagacagccc ctggaagcag aacgtctccc tgtccatcct caagtcccac     2340

gagaatggct tcatggaaga cctggacaag acgtgggttc ggtatcagga atgtgactcg     2400

cgcagcaacg cccctgcgac ccttactttt gagaacatgg ccggggtctt catgctggta     2460

gctgggggca tcgtggccgg gatcttcctg attttcatcg agattgccta caagcggcac     2520

aaggatgctc gccggaagca gatgcagctg gcctttgccg ccgttaacgt gtggcggaag     2580

aacctgcagg atagaaagag tggtagagca gagcctgacc ctaaaaagaa agccacattt     2640

agggctatca cctccaccct ggcttccagc ttcaagaggc gtaggtcctc caaagacacg     2700

agcaccgggg gtggacgcgg cgctttgcaa aaccaaaaag acacagtgct gccgcgacgc     2760

gctattgaga gggaggaggg ccagctgcag ctgtgttccc gtcataggga gagctga        2817


<210>  184
<211>  2706
<212>  DNA
<213>  Homo sapiens

<400>  184
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg      600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc      660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg      720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc      780

tacgccccag acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac      840

atcagcgacg ccgtgggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac      900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc      960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc     1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag     1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc     1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt     1200

gtgacgatcc accaggagcc cttcgtgtac gtcaagccca cgctgagtga tgggacatgc     1260

aaggaggagt tcacagtcaa cggcgaccca gtcaagaagg tgatctgcac cgggcccaac     1320

gacacgtcgc cgggcagccc ccgccacacg gtgcctcagt gttgctacgg cttttgcatc     1380

gacctgctca tcaagctggc acggaccatg aacttcacct acgaggtgca cctggtggca     1440

gatggcaagt tcggcacaca ggagcgggtg aacaacagca acaagaagga gtggaatggg     1500

atgatgggcg agctgctcag cgggcaggca gacatgatcg tggcgccgct aaccataaac     1560

aacgagcgcg cgcagtacat cgagttttcc aagcccttca agtaccaggg cctgactatt     1620

ctggtcaaga aggagattcc ccggagcacg ctggactcgt tcatgcagcc gttccagagc     1680

acactgtggc tgctggtggg gctgtcggtg cacgtggtgg ccgtgatgct gtacctgctg     1740

gaccgcttca gccccttcgg ccggttcaag gtgaacagcg aggaggagga ggaggacgca     1800

ctgaccctgt cctcggccat gtggttctcc tggggcgtcc tgctcaactc cggcatcggg     1860

gaaggcgccc ccagaagctt ctcagcgcgc atcctgggca tggtgtgggc cggctttgcc     1920

atgatcatcg tggcctccta caccgccaac ctggcggcct tcctggtgct ggaccggccg     1980

gaggagcgca tcacgggcat caacgaccct cggctgagga acccctcgga caagtttatc     2040

tacgccacgg tgaagcagag ctccgtggat atctacttcc ggcgccaggt ggagctgagc     2100

accatgtacc ggcatatgga gaagcacaac tacgagagtg cggcggaggc catccaggcc     2160

gtgagagaca acaagctgca tgccttcatc tgggactcgg cggtgctgga gttcgaggcc     2220

tcgcagaagt gcgacctggt gacgactgga gagctgtttt tccgctcggg cttcggcata     2280

ggcatgcgca aagacagccc ctggaagcag aacgtctccc tgtccatcct caagtcccac     2340

gagaatggct tcatggaaga cctggacaag acgtgggttc ggtatcagga atgtgactcg     2400

cgcagcaacg cccctgcgac ccttactttt gagaacatgg ccggggtctt catgctggta     2460

gctgggggca tcgtggccgg gatcttcctg attttcatcg agattgccta caagcggcac     2520

aaggatgctc gccggaagca gatgcagctg gcctttgccg ccgttaacgt gtggcggaag     2580

aacctgcaga gcaccggggg tggacgcggc gctttgcaaa accaaaaaga cacagtgctg     2640

ccgcgacgcg ctattgagag ggaggagggc cagctgcagc tgtgttcccg tcatagggag     2700

agctga                                                                2706


<210>  185
<211>  2832
<212>  DNA
<213>  Homo sapiens

<400>  185
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag agtaaaaaaa ggaactatga aaacctcgac      600

caactgtcct atgacaacaa gcgcggaccc aaggcagaga aggtgctgca gtttgaccca      660

gggaccaaga acgtgacggc cctgctgatg gaggcgaaag agctggaggc ccgggtcatc      720

atcctttctg ccagcgagga cgatgctgcc actgtatacc gcgcagccgc gatgctgaac      780

atgacgggct ccgggtacgt gtggctggtc ggcgagcgcg agatctcggg gaacgccctg      840

cgctacgccc cagacggcat cctcgggctg cagctcatca acggcaagaa cgagtcggcc      900

cacatcagcg acgccgtggg cgtggtggcc caggccgtgc acgagctcct cgagaaggag      960

aacatcaccg acccgccgcg gggctgcgtg ggcaacacca acatctggaa gaccgggccg     1020

ctcttcaaga gagtgctgat gtcttccaag tatgcggatg gggtgactgg tcgcgtggag     1080

ttcaatgagg atggggaccg gaagttcgcc aactacagca tcatgaacct gcagaaccgc     1140

aagctggtgc aagtgggcat ctacaatggc acccacgtca tccctaatga caggaagatc     1200

atctggccag gcggagagac agagaagcct cgagggtacc agatgtccac cagactgaag     1260

attgtgacga tccaccagga gcccttcgtg tacgtcaagc ccacgctgag tgatgggaca     1320

tgcaaggagg agttcacagt caacggcgac ccagtcaaga aggtgatctg caccgggccc     1380

aacgacacgt cgccgggcag cccccgccac acggtgcctc agtgttgcta cggcttttgc     1440

atcgacctgc tcatcaagct ggcacggacc atgaacttca cctacgaggt gcacctggtg     1500

gcagatggca agttcggcac acaggagcgg gtgaacaaca gcaacaagaa ggagtggaat     1560

gggatgatgg gcgagctgct cagcgggcag gcagacatga tcgtggcgcc gctaaccata     1620

aacaacgagc gcgcgcagta catcgagttt tccaagccct tcaagtacca gggcctgact     1680

attctggtca agaaggagat tccccggagc acgctggact cgttcatgca gccgttccag     1740

agcacactgt ggctgctggt ggggctgtcg gtgcacgtgg tggccgtgat gctgtacctg     1800

ctggaccgct tcagcccctt cggccggttc aaggtgaaca gcgaggagga ggaggaggac     1860

gcactgaccc tgtcctcggc catgtggttc tcctggggcg tcctgctcaa ctccggcatc     1920

ggggaaggcg cccccagaag cttctcagcg cgcatcctgg gcatggtgtg ggccggcttt     1980

gccatgatca tcgtggcctc ctacaccgcc aacctggcgg ccttcctggt gctggaccgg     2040

ccggaggagc gcatcacggg catcaacgac cctcggctga ggaacccctc ggacaagttt     2100

atctacgcca cggtgaagca gagctccgtg gatatctact tccggcgcca ggtggagctg     2160

agcaccatgt accggcatat ggagaagcac aactacgaga gtgcggcgga ggccatccag     2220

gccgtgagag acaacaagct gcatgccttc atctgggact cggcggtgct ggagttcgag     2280

gcctcgcaga agtgcgacct ggtgacgact ggagagctgt ttttccgctc gggcttcggc     2340

ataggcatgc gcaaagacag cccctggaag cagaacgtct ccctgtccat cctcaagtcc     2400

cacgagaatg gcttcatgga agacctggac aagacgtggg ttcggtatca ggaatgtgac     2460

tcgcgcagca acgcccctgc gacccttact tttgagaaca tggccggggt cttcatgctg     2520

gtagctgggg gcatcgtggc cgggatcttc ctgattttca tcgagattgc ctacaagcgg     2580

cacaaggatg ctcgccggaa gcagatgcag ctggcctttg ccgccgttaa cgtgtggcgg     2640

aagaacctgc aggatagaaa gagtggtaga gcagagcctg accctaaaaa gaaagccaca     2700

tttagggcta tcacctccac cctggcttcc agcttcaaga ggcgtaggtc ctccaaagac     2760

acgcagtacc atcccactga tatcacgggc ccgctcaacc tctcagatcc ctcggtcagc     2820

accgtggtgt ga                                                         2832


<210>  186
<211>  2658
<212>  DNA
<213>  Homo sapiens

<400>  186
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg      600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc      660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg      720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc      780

tacgccccag acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac      840

atcagcgacg ccgtgggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac      900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc      960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc     1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag     1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc     1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt     1200

gtgacgatcc accaggagcc cttcgtgtac gtcaagccca cgctgagtga tgggacatgc     1260

aaggaggagt tcacagtcaa cggcgaccca gtcaagaagg tgatctgcac cgggcccaac     1320

gacacgtcgc cgggcagccc ccgccacacg gtgcctcagt gttgctacgg cttttgcatc     1380

gacctgctca tcaagctggc acggaccatg aacttcacct acgaggtgca cctggtggca     1440

gatggcaagt tcggcacaca ggagcgggtg aacaacagca acaagaagga gtggaatggg     1500

atgatgggcg agctgctcag cgggcaggca gacatgatcg tggcgccgct aaccataaac     1560

aacgagcgcg cgcagtacat cgagttttcc aagcccttca agtaccaggg cctgactatt     1620

ctggtcaaga aggagattcc ccggagcacg ctggactcgt tcatgcagcc gttccagagc     1680

acactgtggc tgctggtggg gctgtcggtg cacgtggtgg ccgtgatgct gtacctgctg     1740

gaccgcttca gccccttcgg ccggttcaag gtgaacagcg aggaggagga ggaggacgca     1800

ctgaccctgt cctcggccat gtggttctcc tggggcgtcc tgctcaactc cggcatcggg     1860

gaaggcgccc ccagaagctt ctcagcgcgc atcctgggca tggtgtgggc cggctttgcc     1920

atgatcatcg tggcctccta caccgccaac ctggcggcct tcctggtgct ggaccggccg     1980

gaggagcgca tcacgggcat caacgaccct cggctgagga acccctcgga caagtttatc     2040

tacgccacgg tgaagcagag ctccgtggat atctacttcc ggcgccaggt ggagctgagc     2100

accatgtacc ggcatatgga gaagcacaac tacgagagtg cggcggaggc catccaggcc     2160

gtgagagaca acaagctgca tgccttcatc tgggactcgg cggtgctgga gttcgaggcc     2220

tcgcagaagt gcgacctggt gacgactgga gagctgtttt tccgctcggg cttcggcata     2280

ggcatgcgca aagacagccc ctggaagcag aacgtctccc tgtccatcct caagtcccac     2340

gagaatggct tcatggaaga cctggacaag acgtgggttc ggtatcagga atgtgactcg     2400

cgcagcaacg cccctgcgac ccttactttt gagaacatgg ccggggtctt catgctggta     2460

gctgggggca tcgtggccgg gatcttcctg attttcatcg agattgccta caagcggcac     2520

aaggatgctc gccggaagca gatgcagctg gcctttgccg ccgttaacgt gtggcggaag     2580

aacctgcagc agtaccatcc cactgatatc acgggcccgc tcaacctctc agatccctcg     2640

gtcagcaccg tggtgtga                                                   2658


<210>  187
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  187
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag agtaaaaaaa ggaactatga aaacctcgac      600

caactgtcct atgacaacaa gcgcggaccc aaggcagaga aggtgctgca gtttgaccca      660

gggaccaaga acgtgacggc cctgctgatg gaggcgaaag agctggaggc ccgggtcatc      720

atcctttctg ccagcgagga cgatgctgcc actgtatacc gcgcagccgc gatgctgaac      780

atgacgggct ccgggtacgt gtggctggtc ggcgagcgcg agatctcggg gaacgccctg      840

cgctacgccc cagacggcat cctcgggctg cagctcatca acggcaagaa cgagtcggcc      900

cacatcagcg acgccgtggg cgtggtggcc caggccgtgc acgagctcct cgagaaggag      960

aacatcaccg acccgccgcg gggctgcgtg ggcaacacca acatctggaa gaccgggccg     1020

ctcttcaaga gagtgctgat gtcttccaag tatgcggatg gggtgactgg tcgcgtggag     1080

ttcaatgagg atggggaccg gaagttcgcc aactacagca tcatgaacct gcagaaccgc     1140

aagctggtgc aagtgggcat ctacaatggc acccacgtca tccctaatga caggaagatc     1200

atctggccag gcggagagac agagaagcct cgagggtacc agatgtccac cagactgaag     1260

attgtgacga tccaccagga gcccttcgtg tacgtcaagc ccacgctgag tgatgggaca     1320

tgcaaggagg agttcacagt caacggcgac ccagtcaaga aggtgatctg caccgggccc     1380

aacgacacgt cgccgggcag cccccgccac acggtgcctc agtgttgcta cggcttttgc     1440

atcgacctgc tcatcaagct ggcacggacc atgaacttca cctacgaggt gcacctggtg     1500

gcagatggca agttcggcac acaggagcgg gtgaacaaca gcaacaagaa ggagtggaat     1560

gggatgatgg gcgagctgct cagcgggcag gcagacatga tcgtggcgcc gctaaccata     1620

aacaacgagc gcgcgcagta catcgagttt tccaagccct tcaagtacca gggcctgact     1680

attctggtca agaaggagat tccccggagc acgctggact cgttcatgca gccgttccag     1740

agcacactgt ggctgctggt ggggctgtcg gtgcacgtgg tggccgtgat gctgtacctg     1800

ctggaccgct tcagcccctt cggccggttc aaggtgaaca gcgaggagga ggaggaggac     1860

gcactgaccc tgtcctcggc catgtggttc tcctggggcg tcctgctcaa ctccggcatc     1920

ggggaaggcg cccccagaag cttctcagcg cgcatcctgg gcatggtgtg ggccggcttt     1980

gccatgatca tcgtggcctc ctacaccgcc aacctggcgg ccttcctggt gctggaccgg     2040

ccggaggagc gcatcacggg catcaacgac cctcggctga ggaacccctc ggacaagttt     2100

atctacgcca cggtgaagca gagctccgtg gatatctact tccggcgcca ggtggagctg     2160

agcaccatgt accggcatat ggagaagcac aactacgaga gtgcggcgga ggccatccag     2220

gccgtgagag acaacaagct gcatgccttc atctgggact cggcggtgct ggagttcgag     2280

gcctcgcaga agtgcgacct ggtgacgact ggagagctgt ttttccgctc gggcttcggc     2340

ataggcatgc gcaaagacag cccctggaag cagaacgtct ccctgtccat cctcaagtcc     2400

cacgagaatg gcttcatgga agacctggac aagacgtggg ttcggtatca ggaatgtgac     2460

tcgcgcagca acgcccctgc gacccttact tttgagaaca tggccggggt cttcatgctg     2520

gtagctgggg gcatcgtggc cgggatcttc ctgattttca tcgagattgc ctacaagcgg     2580

cacaaggatg ctcgccggaa gcagatgcag ctggcctttg ccgccgttaa cgtgtggcgg     2640

aagaacctgc agcagtacca tcccactgat atcacgggcc cgctcaacct ctcagatccc     2700

tcggtcagca ccgtggtgtg a                                               2721


<210>  188
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
    850                 855                 860                 


Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
865                 870                 875                 880 


Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                885                 890                 895     


Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
            900                 905                 910         


Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
        915                 920                 925             


Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
    930                 935             


<210>  189
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Ser 
    850                 855                 860                 


Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln Lys Asp Thr Val Leu 
865                 870                 875                 880 


Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln Leu Gln Leu Cys Ser 
                885                 890                 895     


Arg His Arg Glu Ser 
            900     


<210>  190
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ser Lys 
            180                 185                 190         


Lys Arg Asn Tyr Glu Asn Leu Asp Gln Leu Ser Tyr Asp Asn Lys Arg 
        195                 200                 205             


Gly Pro Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn 
    210                 215                 220                 


Val Thr Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile 
225                 230                 235                 240 


Ile Leu Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala 
                245                 250                 255     


Ala Met Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu 
            260                 265                 270         


Arg Glu Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu 
        275                 280                 285             


Gly Leu Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp 
    290                 295                 300                 


Ala Val Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu 
305                 310                 315                 320 


Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp 
                325                 330                 335     


Lys Thr Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala 
            340                 345                 350         


Asp Gly Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys 
        355                 360                 365             


Phe Ala Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln 
    370                 375                 380                 


Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile 
385                 390                 395                 400 


Ile Trp Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser 
                405                 410                 415     


Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val 
            420                 425                 430         


Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn 
        435                 440                 445             


Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser 
    450                 455                 460                 


Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys 
465                 470                 475                 480 


Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu 
                485                 490                 495     


Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn 
            500                 505                 510         


Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser 
        515                 520                 525             


Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg 
    530                 535                 540                 


Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr 
545                 550                 555                 560 


Ile Leu Val Lys Lys Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met 
                565                 570                 575     


Gln Pro Phe Gln Ser Thr Leu Trp Leu Leu Val Gly Leu Ser Val His 
            580                 585                 590         


Val Val Ala Val Met Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly 
        595                 600                 605             


Arg Phe Lys Val Asn Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu 
    610                 615                 620                 


Ser Ser Ala Met Trp Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile 
625                 630                 635                 640 


Gly Glu Gly Ala Pro Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val 
                645                 650                 655     


Trp Ala Gly Phe Ala Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu 
            660                 665                 670         


Ala Ala Phe Leu Val Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile 
        675                 680                 685             


Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr 
    690                 695                 700                 


Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu 
705                 710                 715                 720 


Ser Thr Met Tyr Arg His Met Glu Lys His Asn Tyr Glu Ser Ala Ala 
                725                 730                 735     


Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp 
            740                 745                 750         


Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val 
        755                 760                 765             


Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg 
    770                 775                 780                 


Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser 
785                 790                 795                 800 


His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr 
                805                 810                 815     


Gln Glu Cys Asp Ser Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu 
            820                 825                 830         


Asn Met Ala Gly Val Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly 
        835                 840                 845             


Ile Phe Leu Ile Phe Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala 
    850                 855                 860                 


Arg Arg Lys Gln Met Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg 
865                 870                 875                 880 


Lys Asn Leu Gln Asp Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys 
                885                 890                 895     


Lys Lys Ala Thr Phe Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe 
            900                 905                 910         


Lys Arg Arg Arg Ser Ser Lys Asp Thr Gln Tyr His Pro Thr Asp Ile 
        915                 920                 925             


Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser Val Ser Thr Val Val 
    930                 935                 940             


<210>  191
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Gln 
    850                 855                 860                 


Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser 
865                 870                 875                 880 


Val Ser Thr Val Val 
                885 


<210>  192
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ser Lys 
            180                 185                 190         


Lys Arg Asn Tyr Glu Asn Leu Asp Gln Leu Ser Tyr Asp Asn Lys Arg 
        195                 200                 205             


Gly Pro Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn 
    210                 215                 220                 


Val Thr Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile 
225                 230                 235                 240 


Ile Leu Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala 
                245                 250                 255     


Ala Met Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu 
            260                 265                 270         


Arg Glu Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu 
        275                 280                 285             


Gly Leu Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp 
    290                 295                 300                 


Ala Val Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu 
305                 310                 315                 320 


Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp 
                325                 330                 335     


Lys Thr Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala 
            340                 345                 350         


Asp Gly Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys 
        355                 360                 365             


Phe Ala Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln 
    370                 375                 380                 


Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile 
385                 390                 395                 400 


Ile Trp Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser 
                405                 410                 415     


Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val 
            420                 425                 430         


Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn 
        435                 440                 445             


Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser 
    450                 455                 460                 


Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys 
465                 470                 475                 480 


Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu 
                485                 490                 495     


Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn 
            500                 505                 510         


Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser 
        515                 520                 525             


Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg 
    530                 535                 540                 


Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr 
545                 550                 555                 560 


Ile Leu Val Lys Lys Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met 
                565                 570                 575     


Gln Pro Phe Gln Ser Thr Leu Trp Leu Leu Val Gly Leu Ser Val His 
            580                 585                 590         


Val Val Ala Val Met Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly 
        595                 600                 605             


Arg Phe Lys Val Asn Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu 
    610                 615                 620                 


Ser Ser Ala Met Trp Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile 
625                 630                 635                 640 


Gly Glu Gly Ala Pro Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val 
                645                 650                 655     


Trp Ala Gly Phe Ala Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu 
            660                 665                 670         


Ala Ala Phe Leu Val Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile 
        675                 680                 685             


Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr 
    690                 695                 700                 


Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu 
705                 710                 715                 720 


Ser Thr Met Tyr Arg His Met Glu Lys His Asn Tyr Glu Ser Ala Ala 
                725                 730                 735     


Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp 
            740                 745                 750         


Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val 
        755                 760                 765             


Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg 
    770                 775                 780                 


Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser 
785                 790                 795                 800 


His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr 
                805                 810                 815     


Gln Glu Cys Asp Ser Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu 
            820                 825                 830         


Asn Met Ala Gly Val Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly 
        835                 840                 845             


Ile Phe Leu Ile Phe Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala 
    850                 855                 860                 


Arg Arg Lys Gln Met Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg 
865                 870                 875                 880 


Lys Asn Leu Gln Gln Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn 
                885                 890                 895     


Leu Ser Asp Pro Ser Val Ser Thr Val Val 
            900                 905     


<210>  193
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  193
atgagcaaca tctgtcagag gctctgggag tacctagaac cctatctccc ctgtttgtcc       60

acggaggcag acaagtcaac cgtgattgaa aatccagggg ccctttgctc tccccagtca      120

cagaggcatg gccactactt tgtggctttg tttgattacc aggctcggac tgctgaggac      180

ttgagcttcc gagcaggtga caaacttcaa gttctggaca ctttgcatga gggctggtgg      240

tttgccagac acttggagaa aagacgagat ggctccagtc agcaactaca aggctatatt      300

ccttctaact acgtggctga ggacagaagc ctacaggcag agccgtggtt ctttggagca      360

atcggaagat cagatgcaga gaaacaacta ttatattcag aaaacaagac cggttccttt      420

ctaatcagag aaagtgaaag ccaaaaagga gaattctctc tttcagtttt agatggagca      480

gttgtaaaac actacagaat taaaagactg gatgaagggg gattttttct cacgcgaaga      540

agaatctttt caacactgaa cgaatttgtg agccactaca ccaagacaag tgacggcctg      600

tgtgtcaagc tggggaaacc atgcttaaag atccaggtcc cagctccatt tgatttgtcg      660

tataaaaccg tggaccaatg ggagatagac cgcaactcca tacagcttct gaagcgattg      720

ggatctggtc agtttggcga agtatgggaa ggtctgtgga acaataccac tccagtagca      780

gtgaaaacat taaaaccagg ttcaatggat ccaaatgact tcctgaggga ggcacagata      840

atgaagaacc taagacatcc aaagcttatc cagctttatg ctgtttgcac tttagaagat      900

ccaatttata ttattacaga gttgatgaga catggaagtc tgcaagaata tctccaaaat      960

gacactggat caaaaatcca tctgactcaa caggtagaca tggcggcaca ggttgcctct     1020

ggaatggcct atctggagtc tcggaactac attcacagag atctggctgc cagaaatgtc     1080

ctcgttggtg aacataatat ctacaaagta gcagattttg gacttgccag agtttttaag     1140

gtagataatg aagacatcta tgaatctaga cacgaaataa agctgccggt gaagtggact     1200

gcgcccgaag ccattcgtag taataaattc agcattaagt ccgatgtatg gtcatttgga     1260

atccttcttt atgaaatcat tacttatggc aaaatgcctt acagtggtat gacaggtgcc     1320

caggtaatcc agatgttggc tcaaaactat agacttccgc aaccatccaa ctgtccacag     1380

caattttaca acatcatgtt ggagtgctgg aatgcagagc ctaaggaacg acctacattt     1440

gagacactgc gttggaaact tgaagactat tttgaaacag actcttcata ttcagatgca     1500

aataacttca taagatga                                                   1518


<210>  194
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210>  195
<211>  1539
<212>  DNA
<213>  Mus musculus

<400>  195
atgggcagcg tctgtgtgag actctgggca tacctgcagc cttttctccc gtgctggtct       60

caagaggcag acaagtcagt agtaattgag aatccagggg ccttctgtcc cccagaggct      120

cccaggtcac aagagcccga gagaagccat ggccagtatt ttgtggctct gtttgattac      180

caagcacgta ctgcagagga cctgagcttc cgtgccggcg acaaactcca agtcttggac      240

acttcgcatg agggctggtg gttggccaga catttggaga agaagggaac cggcttaggt      300

cagcagctac agggctacat tccttccaat tacgtggcgg aggaccggag tctccaggca      360

gagccgtggt tttttggagc aatcaaaaga gcagatgcag aaaaacaact tctgtattca      420

gaaaaccaga cgggcgcctt tctaatcaga gagagtgaga gccagaaggg tgacttttcc      480

ctctcagttt tagatgaagg tgttgtaaaa cactacagaa taagaaggtt ggatgaaggt      540

ggcttcttcc tcaccaggag gaaagtcttt tcaaccctga atgaattcgt gaactactac      600

accacaacaa gtgacgggct gtgtgtcaag ctggagaagc catgcttaaa gatccaggta      660

ccaacccctt ttgatttgtc atataaaact gcagaccagt gggagataga ccgcaactcc      720

atacagcttt tgaagcgact gggatctggt cagtttggag aagtttggga aggtctgtgg      780

aataatacca ctccagtggc cgtaaaaacg ttaaaaccag gttcaatgga tccaaatgac      840

ttcctgaggg aggcacagat aatgaagagc ctaagacacc caaaactcat ccagctctat      900

gctgtttgca ctttagaaga tcccatttat attattacag agttgatgag acatggaagc      960

ctgcaagaat atctccaaaa tgatggtggg tcaaaaatcc atttgattca acaggtagac     1020

atggcggcac aggtggcttc tggaatggcc tatcttgagt cgcagaacta tattcacaga     1080

gatctggctg caagaaatgt ccttgttggt gaacataata tctacaaagt agcagatttt     1140

ggacttgcaa gagtttttaa ggtagataat gaagacatct atgaatctaa acacgaaata     1200

aagctgccag tgaagtggac tgcacccgaa gccattcgta ctaataaatt cagcattaag     1260

tctgatgtgt ggtcttttgg aatcctgctc tatgaaatca ttacttatgg caaaatgcct     1320

tacagtggta tgacaggtgc tcaagtaatt caaatgttga gtcaaaacta cagacttcca     1380

cagccatcta actgcccaca gcaattctac agcatcatgc tagagtgctg gaatgttgag     1440

cctaagcaac ggccaacatt tgagaccctg cattggaaac ttgaagacta ctttgaaaca     1500

gactgttcct attcagatac aaataacttc ataaactaa                            1539


<210>  196
<211>  1539
<212>  DNA
<213>  Mus musculus

<400>  196
atgggcagcg tctgtgtgag actctgggca tacctgcagc cttttctccc gtgctggtct       60

caagaggcag acaagtcagt agtaattgag aatccagggg ccttctgtcc cccagaggct      120

cccaggtcac aagagcccga gagaagccat ggccagtatt ttgtggctct gtttgattac      180

caagcacgta ctgcagagga cctgagcttc cgtgccggcg acaaactcca agtcttggac      240

acttcgcatg agggctggtg gttggccaga catttggaga agaagggaac cggcttaggt      300

cagcagctac agggctacat tccttccaat tacgtggcgg aggaccggag tctccaggca      360

gagccgtggt tttttggagc aatcaaaaga gcagatgcag aaaaacaact tctgtattca      420

gaaaaccaga cgggcgcctt tctaatcaga gagagtgaga gccagaaggg tgacttttcc      480

ctctcagttt tagatgaagg tgttgtaaaa cactacagaa taagaaggtt ggatgaaggt      540

ggcttcttcc tcaccaggag gaaagtcttt tcaaccctga atgaattcgt gaactactac      600

accacaacaa gtgacgggct gtgtgtcaag ctggagaagc catgcttaaa gatccaggta      660

ccaacccctt ttgatttgtc atataaaact gcagaccagt gggagataga ccgcaactcc      720

atacagcttt tgaagcgact gggatctggt cagtttggag aagtttggga aggtctgtgg      780

aataatacca ctccagtggc cgtaaaaacg ttaaaaccag gttcaatgga tccaaatgac      840

ttcctgaggg aggcacagat aatgaagagc ctaagacacc caaaactcat ccagctctat      900

gctgtttgca ctttagaaga tcccatttat attattacag agttgatgag acatggaagc      960

ctgcaagaat atctccaaaa tgatggtggg tcaaaaatcc atttgattca acaggtagac     1020

atggcggcac aggtggcttc tggaatggcc tatcttgagt cgcagaacta tattcacaga     1080

gatctggctg caagaaatgt ccttgttggt gaacataata tctacaaagt agcagatttt     1140

ggacttgcaa gagtttttaa ggtagataat gaagacatct atgaatctaa acacgaaata     1200

aagctgccag tgaagtggac tgcacccgaa gccattcgta ctaataaatt cagcattaag     1260

tctgatgtgt ggtcttttgg aatcctgctc tatgaaatca ttacttatgg caaaatgcct     1320

tacagtggta tgacaggtgc tcaagtaatt caaatgttga gtcaaaacta cagacttcca     1380

cagccatcta actgcccaca gcaattctac agcatcatgc tagagtgctg gaatgttgag     1440

cctaagcaac ggccaacatt tgagaccctg cattggaaac ttgaagacta ctttgaaaca     1500

gactgttcct attcagatac aaataacttc ataaactaa                            1539


<210>  197
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  197

Met Gly Ser Val Cys Val Arg Leu Trp Ala Tyr Leu Gln Pro Phe Leu 
1               5                   10                  15      


Pro Cys Trp Ser Gln Glu Ala Asp Lys Ser Val Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Phe Cys Pro Pro Glu Ala Pro Arg Ser Gln Glu Pro Glu Arg 
        35                  40                  45              


Ser His Gly Gln Tyr Phe Val Ala Leu Phe Asp Tyr Gln Ala Arg Thr 
    50                  55                  60                  


Ala Glu Asp Leu Ser Phe Arg Ala Gly Asp Lys Leu Gln Val Leu Asp 
65                  70                  75                  80  


Thr Ser His Glu Gly Trp Trp Leu Ala Arg His Leu Glu Lys Lys Gly 
                85                  90                  95      


Thr Gly Leu Gly Gln Gln Leu Gln Gly Tyr Ile Pro Ser Asn Tyr Val 
            100                 105                 110         


Ala Glu Asp Arg Ser Leu Gln Ala Glu Pro Trp Phe Phe Gly Ala Ile 
        115                 120                 125             


Lys Arg Ala Asp Ala Glu Lys Gln Leu Leu Tyr Ser Glu Asn Gln Thr 
    130                 135                 140                 


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Gln Lys Gly Asp Phe Ser 
145                 150                 155                 160 


Leu Ser Val Leu Asp Glu Gly Val Val Lys His Tyr Arg Ile Arg Arg 
                165                 170                 175     


Leu Asp Glu Gly Gly Phe Phe Leu Thr Arg Arg Lys Val Phe Ser Thr 
            180                 185                 190         


Leu Asn Glu Phe Val Asn Tyr Tyr Thr Thr Thr Ser Asp Gly Leu Cys 
        195                 200                 205             


Val Lys Leu Glu Lys Pro Cys Leu Lys Ile Gln Val Pro Thr Pro Phe 
    210                 215                 220                 


Asp Leu Ser Tyr Lys Thr Ala Asp Gln Trp Glu Ile Asp Arg Asn Ser 
225                 230                 235                 240 


Ile Gln Leu Leu Lys Arg Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Glu Gly Leu Trp Asn Asn Thr Thr Pro Val Ala Val Lys Thr Leu Lys 
            260                 265                 270         


Pro Gly Ser Met Asp Pro Asn Asp Phe Leu Arg Glu Ala Gln Ile Met 
        275                 280                 285             


Lys Ser Leu Arg His Pro Lys Leu Ile Gln Leu Tyr Ala Val Cys Thr 
    290                 295                 300                 


Leu Glu Asp Pro Ile Tyr Ile Ile Thr Glu Leu Met Arg His Gly Ser 
305                 310                 315                 320 


Leu Gln Glu Tyr Leu Gln Asn Asp Gly Gly Ser Lys Ile His Leu Ile 
                325                 330                 335     


Gln Gln Val Asp Met Ala Ala Gln Val Ala Ser Gly Met Ala Tyr Leu 
            340                 345                 350         


Glu Ser Gln Asn Tyr Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
        355                 360                 365             


Val Gly Glu His Asn Ile Tyr Lys Val Ala Asp Phe Gly Leu Ala Arg 
    370                 375                 380                 


Val Phe Lys Val Asp Asn Glu Asp Ile Tyr Glu Ser Lys His Glu Ile 
385                 390                 395                 400 


Lys Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Ile Arg Thr Asn Lys 
                405                 410                 415     


Phe Ser Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu 
            420                 425                 430         


Ile Ile Thr Tyr Gly Lys Met Pro Tyr Ser Gly Met Thr Gly Ala Gln 
        435                 440                 445             


Val Ile Gln Met Leu Ser Gln Asn Tyr Arg Leu Pro Gln Pro Ser Asn 
    450                 455                 460                 


Cys Pro Gln Gln Phe Tyr Ser Ile Met Leu Glu Cys Trp Asn Val Glu 
465                 470                 475                 480 


Pro Lys Gln Arg Pro Thr Phe Glu Thr Leu His Trp Lys Leu Glu Asp 
                485                 490                 495     


Tyr Phe Glu Thr Asp Cys Ser Tyr Ser Asp Thr Asn Asn Phe Ile Asn 
            500                 505                 510         


<210>  198
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  198

Met Gly Ser Val Cys Val Arg Leu Trp Ala Tyr Leu Gln Pro Phe Leu 
1               5                   10                  15      


Pro Cys Trp Ser Gln Glu Ala Asp Lys Ser Val Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Phe Cys Pro Pro Glu Ala Pro Arg Ser Gln Glu Pro Glu Arg 
        35                  40                  45              


Ser His Gly Gln Tyr Phe Val Ala Leu Phe Asp Tyr Gln Ala Arg Thr 
    50                  55                  60                  


Ala Glu Asp Leu Ser Phe Arg Ala Gly Asp Lys Leu Gln Val Leu Asp 
65                  70                  75                  80  


Thr Ser His Glu Gly Trp Trp Leu Ala Arg His Leu Glu Lys Lys Gly 
                85                  90                  95      


Thr Gly Leu Gly Gln Gln Leu Gln Gly Tyr Ile Pro Ser Asn Tyr Val 
            100                 105                 110         


Ala Glu Asp Arg Ser Leu Gln Ala Glu Pro Trp Phe Phe Gly Ala Ile 
        115                 120                 125             


Lys Arg Ala Asp Ala Glu Lys Gln Leu Leu Tyr Ser Glu Asn Gln Thr 
    130                 135                 140                 


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Gln Lys Gly Asp Phe Ser 
145                 150                 155                 160 


Leu Ser Val Leu Asp Glu Gly Val Val Lys His Tyr Arg Ile Arg Arg 
                165                 170                 175     


Leu Asp Glu Gly Gly Phe Phe Leu Thr Arg Arg Lys Val Phe Ser Thr 
            180                 185                 190         


Leu Asn Glu Phe Val Asn Tyr Tyr Thr Thr Thr Ser Asp Gly Leu Cys 
        195                 200                 205             


Val Lys Leu Glu Lys Pro Cys Leu Lys Ile Gln Val Pro Thr Pro Phe 
    210                 215                 220                 


Asp Leu Ser Tyr Lys Thr Ala Asp Gln Trp Glu Ile Asp Arg Asn Ser 
225                 230                 235                 240 


Ile Gln Leu Leu Lys Arg Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Glu Gly Leu Trp Asn Asn Thr Thr Pro Val Ala Val Lys Thr Leu Lys 
            260                 265                 270         


Pro Gly Ser Met Asp Pro Asn Asp Phe Leu Arg Glu Ala Gln Ile Met 
        275                 280                 285             


Lys Ser Leu Arg His Pro Lys Leu Ile Gln Leu Tyr Ala Val Cys Thr 
    290                 295                 300                 


Leu Glu Asp Pro Ile Tyr Ile Ile Thr Glu Leu Met Arg His Gly Ser 
305                 310                 315                 320 


Leu Gln Glu Tyr Leu Gln Asn Asp Gly Gly Ser Lys Ile His Leu Ile 
                325                 330                 335     


Gln Gln Val Asp Met Ala Ala Gln Val Ala Ser Gly Met Ala Tyr Leu 
            340                 345                 350         


Glu Ser Gln Asn Tyr Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
        355                 360                 365             


Val Gly Glu His Asn Ile Tyr Lys Val Ala Asp Phe Gly Leu Ala Arg 
    370                 375                 380                 


Val Phe Lys Val Asp Asn Glu Asp Ile Tyr Glu Ser Lys His Glu Ile 
385                 390                 395                 400 


Lys Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Ile Arg Thr Asn Lys 
                405                 410                 415     


Phe Ser Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu 
            420                 425                 430         


Ile Ile Thr Tyr Gly Lys Met Pro Tyr Ser Gly Met Thr Gly Ala Gln 
        435                 440                 445             


Val Ile Gln Met Leu Ser Gln Asn Tyr Arg Leu Pro Gln Pro Ser Asn 
    450                 455                 460                 


Cys Pro Gln Gln Phe Tyr Ser Ile Met Leu Glu Cys Trp Asn Val Glu 
465                 470                 475                 480 


Pro Lys Gln Arg Pro Thr Phe Glu Thr Leu His Trp Lys Leu Glu Asp 
                485                 490                 495     


Tyr Phe Glu Thr Asp Cys Ser Tyr Ser Asp Thr Asn Asn Phe Ile Asn 
            500                 505                 510         


<210>  199
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  199
atggggctgg taagtagcaa aaagccggac aaggaaaagc cgatcaaaga gaaggacaag       60

ggccaatgga gccccctgaa ggtcagcgcc caagacaagg acgccccgcc actgccgccc      120

ctggttgtct tcaaccacct tactcctcca ccgcccgatg aacacctgga tgaagacaag      180

catttcgtgg tggctctgta tgactacacc gctatgaatg atcgggacct gcagatgctg      240

aagggggaga agctacaggt cctgaaggga actggagact ggtggctggc caggtcactc      300

gtcacaggaa gagaaggcta tgtgcccagt aactttgtgg cccgagtgga gagcctggaa      360

atggaaaggt ggttctttag atcacagggt cggaaggagg ctgagaggca gcttcttgct      420

ccaatcaaca aggccggctc ctttcttatc agagagagtg aaaccaacaa aggtgccttc      480

tccctgtctg tgaaggatgt caccacccag ggggagctga tcaagcacta taagatccgc      540

tgcctggatg aagggggcta ctacatctcc ccccggatca ccttcccctc gctccaggcc      600

ctggtgcagc actattctaa gaagggggat ggtctatgcc agaggctgac cctgccctgt      660

gtgcgcccgg ccccgcagaa tccctgggcc caggatgaat gggagatccc ccggcagtct      720

ctcaggctgg tcaggaaact cgggtctgga caattcggcg aagtctggat gggttactac      780

aaaaacaaca tgaaggtggc cattaagacg ctgaaggagg gaaccatgtc tccagaagcc      840

tttctgggtg aggccaacgt gatgaaggct ctgcagcacg agcggctggt ccgactctac      900

gcagtggtca ccaaggagcc catctacatt gtcaccgagt acatggccag aggatgcctg      960

ctggatttcc tgaagacaga tgaagggagc agattgtcac tcccaaggct gattgacatg     1020

tcggcgcaga ttgctgaagg gatggcatac attgagcgca tgaattccat ccaccgcgac     1080

ctgcgggcgg ccaacatcct ggtgtctgag gccttgtgct gcaaaattgc tgattttggc     1140

ttggctcgaa tcatcgacag tgaatacacg gcccaagagg gggccaagtt ccccatcaag     1200

tggacagccc cggaagccat ccacttcggg gtcttcacca tcaaagcaga cgtgtggtcg     1260

tttggagtcc tcctgatgga agttgtcact tatgggcggg tgccataccc agggatgagc     1320

aaccccgagg tcatccgcaa cctggagcgc ggctaccgca tgccgcgccc cgacacctgc     1380

ccgcccgagc tgtaccgcgg cgtcatcgcc gagtgctggc gcagccggcc cgaggagcgg     1440

cccaccttcg agttcctgca gtcggtgctg gaggacttct acacggccac cgagcggcag     1500

tacgagctgc agccctag                                                   1518


<210>  200
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210>  201
<211>  1500
<212>  DNA
<213>  Mus musculus

<400>  201
atggggctgc tgagcagcaa gaggcaggtc agtgagaagg gcaagggctg gagccccgtg       60

aagatccgca cccaggacaa ggctccccca cccctgccac ccctggttgt cttcaaccac      120

cttgccccac catctcctaa ccaggaccca gatgaagagg agcgttttgt ggtggctctg      180

tttgactatg ccgctgtgaa tgacagggac cttcaggtgc tgaagggtga gaagctccag      240

gtcttgagga gcactggaga ctggtggttg gccaggtcac tcgtcacagg aagagaaggt      300

tatgtgccca gcaactttgt ggccccagta gagactctgg aagtagaaaa atggttcttc      360

aggaccatca gccggaagga tgctgagagg cagttgctgg ctccgatgaa caaggccggc      420

tcctttctca tcagagagag tgagagcaat aaaggtgcct tttccctgtc cgtgaaagat      480

atcaccaccc agggggaggt ggtcaagcac tataagatcc gatcactgga caatggaggc      540

tattacatct ccccccggat cacctttccc accctccagg ccctggtgca gcactattca      600

aagaaagggg atggtttgtg tcagaagttg actctgccct gtgtgaacct ggccccgaag      660

aacctttggg cccaagatga atgggaaatc cccaggcagt ctctcaagtt ggtccggaaa      720

cttgggtctg ggcagtttgg cgaagtctgg atgggttatt acaaaaataa catgaaggtg      780

gccatcaaga ccctgaagga gggaaccatg tcaccggaag ctttcctggg cgaggccaac      840

gtgatgaaaa ccctgcagca tgagaggctg gttcgtctct acgctgtggt caccagagag      900

cccatttaca tcgtcactga atacatggcc agaggatgct tgctggattt tctgaagacc      960

gatgaaggta gcaggttgtc ccttccaagg ctgattgaca tgtcagccca ggttgcagag     1020

gggatggctt acatagagcg catgaattcc atccaccgtg acctgcgggc agccaacatc     1080

ctggtgtctg agacgttgtg ctgcaaaatc gctgacttcg gcttggccag gatcattgac     1140

agtgaataca ctgcccaaga gggggccaag ttccccatca agtggaccgc cccggaggcc     1200

atccacttcg gggtgtttac catcaaggct gatgtgtggt ccttcggagt cttgctgatg     1260

gagattgtca cctatgggcg cgttccctac ccaggaatga gcaaccctga ggtcatccgt     1320

agcctggagc acggctaccg aatgccatgc ccggagacat gtccaccgga gttgtacaat     1380

gatatcatca ctgagtgctg gcggggccgg ccagaggagc ggcctacctt tgagttcctg     1440

cagtcggtgt tggaggactt ctacacagcc acggagggcc aatatgagct gcagccctag     1500


<210>  202
<211>  499
<212>  PRT
<213>  Mus musculus

<400>  202

Met Gly Leu Leu Ser Ser Lys Arg Gln Val Ser Glu Lys Gly Lys Gly 
1               5                   10                  15      


Trp Ser Pro Val Lys Ile Arg Thr Gln Asp Lys Ala Pro Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Val Val Phe Asn His Leu Ala Pro Pro Ser Pro Asn Gln 
        35                  40                  45              


Asp Pro Asp Glu Glu Glu Arg Phe Val Val Ala Leu Phe Asp Tyr Ala 
    50                  55                  60                  


Ala Val Asn Asp Arg Asp Leu Gln Val Leu Lys Gly Glu Lys Leu Gln 
65                  70                  75                  80  


Val Leu Arg Ser Thr Gly Asp Trp Trp Leu Ala Arg Ser Leu Val Thr 
                85                  90                  95      


Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe Val Ala Pro Val Glu Thr 
            100                 105                 110         


Leu Glu Val Glu Lys Trp Phe Phe Arg Thr Ile Ser Arg Lys Asp Ala 
        115                 120                 125             


Glu Arg Gln Leu Leu Ala Pro Met Asn Lys Ala Gly Ser Phe Leu Ile 
    130                 135                 140                 


Arg Glu Ser Glu Ser Asn Lys Gly Ala Phe Ser Leu Ser Val Lys Asp 
145                 150                 155                 160 


Ile Thr Thr Gln Gly Glu Val Val Lys His Tyr Lys Ile Arg Ser Leu 
                165                 170                 175     


Asp Asn Gly Gly Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Thr Leu 
            180                 185                 190         


Gln Ala Leu Val Gln His Tyr Ser Lys Lys Gly Asp Gly Leu Cys Gln 
        195                 200                 205             


Lys Leu Thr Leu Pro Cys Val Asn Leu Ala Pro Lys Asn Leu Trp Ala 
    210                 215                 220                 


Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser Leu Lys Leu Val Arg Lys 
225                 230                 235                 240 


Leu Gly Ser Gly Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Lys Asn 
                245                 250                 255     


Asn Met Lys Val Ala Ile Lys Thr Leu Lys Glu Gly Thr Met Ser Pro 
            260                 265                 270         


Glu Ala Phe Leu Gly Glu Ala Asn Val Met Lys Thr Leu Gln His Glu 
        275                 280                 285             


Arg Leu Val Arg Leu Tyr Ala Val Val Thr Arg Glu Pro Ile Tyr Ile 
    290                 295                 300                 


Val Thr Glu Tyr Met Ala Arg Gly Cys Leu Leu Asp Phe Leu Lys Thr 
305                 310                 315                 320 


Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg Leu Ile Asp Met Ser Ala 
                325                 330                 335     


Gln Val Ala Glu Gly Met Ala Tyr Ile Glu Arg Met Asn Ser Ile His 
            340                 345                 350         


Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser Glu Thr Leu Cys Cys 
        355                 360                 365             


Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile Ile Asp Ser Glu Tyr Thr 
    370                 375                 380                 


Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala 
385                 390                 395                 400 


Ile His Phe Gly Val Phe Thr Ile Lys Ala Asp Val Trp Ser Phe Gly 
                405                 410                 415     


Val Leu Leu Met Glu Ile Val Thr Tyr Gly Arg Val Pro Tyr Pro Gly 
            420                 425                 430         


Met Ser Asn Pro Glu Val Ile Arg Ser Leu Glu His Gly Tyr Arg Met 
        435                 440                 445             


Pro Cys Pro Glu Thr Cys Pro Pro Glu Leu Tyr Asn Asp Ile Ile Thr 
    450                 455                 460                 


Glu Cys Trp Arg Gly Arg Pro Glu Glu Arg Pro Thr Phe Glu Phe Leu 
465                 470                 475                 480 


Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Glu 
                485                 490                 495     


Leu Gln Pro 
            


<210>  203
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  203
atgggctgtg tgcaatgtaa ggataaagaa gcaacaaaac tgacggagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggtg tgacctccat ccccaactac aacaacttcc acgcagccgg gggccaagga      180

ctcaccgtct ttggaggtgt gaactcttcg tctcatacgg ggaccttgcg tacgagagga      240

ggaacaggag tgacactctt tgtggccctt tatgactatg aagcacggac agaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agattggtgg      360

gaagcccgct ccttgacaac tggagagaca ggttacattc ccagcaatta tgtggctcca      420

gttgactcta tccaggcaga agagtggtac tttggaaaac ttggccgaaa agatgctgag      480

cgacagctat tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagtgaaacc      540

accaaaggtg cctattcact ttctatccgt gattgggatg atatgaaagg agaccatgtc      600

aaacattata aaattcgcaa acttgacaat ggtggatact acattaccac ccgggcccag      660

tttgaaacac ttcagcagct tgtacaacat tactcagaga gagctgcagg tctctgctgc      720

cgcctagtag ttccctgtca caaagggatg ccaaggctta ccgatctgtc tgtcaaaacc      780

aaagatgtct gggaaatccc tcgagaatcc ctgcagttga tcaagagact gggaaatggg      840

cagtttgggg aagtatggat gggtacctgg aatggaaaca caaaagtagc cataaagact      900

cttaaaccag gcacaatgtc ccccgaatca ttccttgagg aagcgcagat catgaagaag      960

ctgaagcacg acaagctggt ccagctctat gcagtggtgt ctgaggagcc catctacatc     1020

gtcaccgagt atatgaacaa aggaagttta ctggatttct taaaagatgg agaaggaaga     1080

gctctgaaat taccaaatct tgtggacatg gcagcacagg tggctgcagg aatggcttac     1140

atcgagcgca tgaattatat ccatagagat ctgcgatcag caaacattct agtggggaat     1200

ggactcatat gcaagattgc tgacttcgga ttggcccgat tgatagaaga caatgagtac     1260

acagcaagac aaggtgcaaa gttccccatc aagtggacgg cccccgaggc agccctgtac     1320

gggaggttca caatcaagtc tgacgtgtgg tcttttggaa tcttactcac agagctggtc     1380

accaaaggaa gagtgccata cccaggcatg aacaaccggg aggtgctgga gcaggtggag     1440

cgaggctaca ggatgccctg cccgcaggac tgccccatct ctctgcatga gctcatgatc     1500

cactgctgga aaaaggaccc tgaagaacgc cccacttttg agtacttgca gagcttcctg     1560

gaagactact ttaccgcgac agagccccag taccaacctg gtgaaaacct gtaa           1614


<210>  204
<211>  1605
<212>  DNA
<213>  Homo sapiens

<400>  204
atgggctgtg tgcaatgtaa ggataaagaa gcaacaaaac tgacggagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggtg tgacctccat ccccaactac aacaacttcc acgcagccgg gggccaagga      180

ctcaccgtct ttggaggtgt gaactcttcg tctcatacgg ggaccttgcg tacgagagga      240

ggaacaggag tgacactctt tgtggccctt tatgactatg aagcacggac agaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agattggtgg      360

gaagcccgct ccttgacaac tggagagaca ggttacattc ccagcaatta tgtggctcca      420

gttgactcta tccaggcaga agagtggtac tttggaaaac ttggccgaaa agatgctgag      480

cgacagctat tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagtgaaacc      540

accaaaggtg cctattcact ttctatccgt gattgggatg atatgaaagg agaccatgtc      600

aaacattata aaattcgcaa acttgacaat ggtggatact acattaccac ccgggcccag      660

tttgaaacac ttcagcagct tgtacaacat tactcagaga aagctgatgg tttgtgtttt      720

aacttaactg tgattgcatc gagttgtacc ccacaaactt ctggattggc taaagatgct      780

tgggaagttg cacgtcgttc gttgtgtctg gagaagaagc tgggtcaggg gtgtttcgct      840

gaagtgtggc ttggtacctg gaatggaaac acaaaagtag ccataaagac tcttaaacca      900

ggcacaatgt cccccgaatc attccttgag gaagcgcaga tcatgaagaa gctgaagcac      960

gacaagctgg tccagctcta tgcagtggtg tctgaggagc ccatctacat cgtcaccgag     1020

tatatgaaca aaggaagttt actggatttc ttaaaagatg gagaaggaag agctctgaaa     1080

ttaccaaatc ttgtggacat ggcagcacag gtggctgcag gaatggctta catcgagcgc     1140

atgaattata tccatagaga tctgcgatca gcaaacattc tagtggggaa tggactcata     1200

tgcaagattg ctgacttcgg attggcccga ttgatagaag acaatgagta cacagcaaga     1260

caaggtgcaa agttccccat caagtggacg gcccccgagg cagccctgta cgggaggttc     1320

acaatcaagt ctgacgtgtg gtcttttgga atcttactca cagagctggt caccaaagga     1380

agagtgccat acccaggcat gaacaaccgg gaggtgctgg agcaggtgga gcgaggctac     1440

aggatgccct gcccgcagga ctgccccatc tctctgcatg agctcatgat ccactgctgg     1500

aaaaaggacc ctgaagaacg ccccactttt gagtacttgc agagcttcct ggaagactac     1560

tttaccgcga cagagcccca gtaccaacct ggtgaaaacc tgtaa                     1605


<210>  205
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  205
atgggctgtg tgcaatgtaa ggataaagaa gcaacaaaac tgacggagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggtg tgacctccat ccccaactac aacaacttcc acgcagccgg gggccaagga      180

ctcaccgtct ttggaggtgt gaactcttcg tctcatacgg ggaccttgcg tacgagagga      240

ggaacaggag tgacactctt tgtggccctt tatgactatg aagcacggac agaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agattggtgg      360

gaagcccgct ccttgacaac tggagagaca ggttacattc ccagcaatta tgtggctcca      420

gttgactcta tccaggcaga agagtggtac tttggaaaac ttggccgaaa agatgctgag      480

cgacagctat tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagtgaaacc      540

accaaaggtg cctattcact ttctatccgt gattgggatg atatgaaagg agaccatgtc      600

aaacattata aaattcgcaa acttgacaat ggtggatact acattaccac ccgggcccag      660

tttgaaacac ttcagcagct tgtacaacat tactcaggta cctggaatgg aaacacaaaa      720

gtagccataa agactcttaa accaggcaca atgtcccccg aatcattcct tgaggaagcg      780

cagatcatga agaagctgaa gcacgacaag ctggtccagc tctatgcagt ggtgtctgag      840

gagcccatct acatcgtcac cgagtatatg aacaaaggaa gtttactgga tttcttaaaa      900

gatggagaag gaagagctct gaaattacca aatcttgtgg acatggcagc acaggtggct      960

gcaggaatgg cttacatcga gcgcatgaat tatatccata gagatctgcg atcagcaaac     1020

attctagtgg ggaatggact catatgcaag attgctgact tcggattggc ccgattgata     1080

gaagacaatg agtacacagc aagacaaggt gcaaagttcc ccatcaagtg gacggccccc     1140

gaggcagccc tgtacgggag gttcacaatc aagtctgacg tgtggtcttt tggaatctta     1200

ctcacagagc tggtcaccaa aggaagagtg ccatacccag gcatgaacaa ccgggaggtg     1260

ctggagcagg tggagcgagg ctacaggatg ccctgcccgc aggactgccc catctctctg     1320

catgagctca tgatccactg ctggaaaaag gaccctgaag aacgccccac ttttgagtac     1380

ttgcagagct tcctggaaga ctactttacc gcgacagagc cccagtacca acctggtgaa     1440

aacctgtaa                                                             1449


<210>  206
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  207
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Lys Ala Asp Gly Leu Cys Phe 
225                 230                 235                 240 


Asn Leu Thr Val Ile Ala Ser Ser Cys Thr Pro Gln Thr Ser Gly Leu 
                245                 250                 255     


Ala Lys Asp Ala Trp Glu Val Ala Arg Arg Ser Leu Cys Leu Glu Lys 
            260                 265                 270         


Lys Leu Gly Gln Gly Cys Phe Ala Glu Val Trp Leu Gly Thr Trp Asn 
        275                 280                 285             


Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser 
    290                 295                 300                 


Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His 
305                 310                 315                 320 


Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr 
                325                 330                 335     


Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            340                 345                 350         


Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala 
        355                 360                 365             


Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile 
    370                 375                 380                 


His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile 
385                 390                 395                 400 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
                405                 410                 415     


Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            420                 425                 430         


Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser 
        435                 440                 445             


Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr 
    450                 455                 460                 


Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr 
465                 470                 475                 480 


Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met 
                485                 490                 495     


Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr 
            500                 505                 510         


Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr 
        515                 520                 525             


Gln Pro Gly Glu Asn Leu 
    530                 


<210>  208
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Gly Thr Trp Asn Gly Asn Thr Lys 
225                 230                 235                 240 


Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Glu Ser Phe 
                245                 250                 255     


Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His Asp Lys Leu Val 
            260                 265                 270         


Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu 
        275                 280                 285             


Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys Asp Gly Glu Gly 
    290                 295                 300                 


Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala Ala Gln Val Ala 
305                 310                 315                 320 


Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu 
                325                 330                 335     


Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile Cys Lys Ile Ala 
            340                 345                 350         


Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
        355                 360                 365             


Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu 
    370                 375                 380                 


Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
385                 390                 395                 400 


Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Asn 
                405                 410                 415     


Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys 
            420                 425                 430         


Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met Ile His Cys Trp 
        435                 440                 445             


Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe 
    450                 455                 460                 


Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu 
465                 470                 475                 480 


Asn Leu 
        


<210>  209
<211>  1614
<212>  DNA
<213>  Mus musculus

<400>  209
atgggctgtg tgcaatgtaa ggataaagaa gcagcgaaac tgacagagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggcg tgacctccat cccgaactac aacaacttcc acgcagctgg gggccaggga      180

ctcaccgtct ttgggggtgt gaactcctcc tctcacactg ggaccctacg cacgagagga      240

gggacaggag tgacactgtt tgtggcgctt tatgactatg aagcacggac ggaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agactggtgg      360

gaagcccgct ccttgacaac cggggaaact ggttacattc ccagcaatta cgtggctcca      420

gttgactcca tccaggcaga agagtggtac tttggaaaac ttggccgcaa agatgctgag      480

agacagctcc tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagcgaaacc      540

accaaaggtg cctactcact ttccatccgt gattgggatg atatgaaagg ggaccacgtc      600

aaacattata aaatccgcaa gcttgacaat ggtggatact atatcacaac gcgggcccag      660

tttgaaacac ttcagcaact ggtacagcat tactcagaga gagccgcagg tctctgctgc      720

cgcctagtag ttccctgtca caaagggatg ccaaggctta ccgatctgtc tgtcaaaacc      780

aaagatgtct gggaaatccc tcgagaatcc ctgcagttga tcaagagact gggaaatggg      840

cagtttgggg aagtatggat gggtacctgg aatggaaata caaaagtagc cataaagacc      900

cttaagccag gcaccatgtc tccggagtcc ttcctggagg aggcgcagat catgaagaag      960

ctgaagcatg acaagctggt gcagctctac gcggtcgtgt ctgaggagcc catttacatc     1020

gtcacggagt acatgagcaa aggaagtttg cttgacttct taaaagatgg tgaaggaaga     1080

gctctgaagt tgccaaacct tgtggacatg gcggcacagg ttgctgcagg aatggcttac     1140

atcgagcgca tgaattatat ccacagagat ctgcgatcag caaacattct agtggggaat     1200

ggactaattt gcaagattgc tgactttgga ttggctcggt tgattgaaga caatgaatac     1260

acagcaagac aaggtgcgaa gtttcccatt aagtggacag cccccgaagc ggccctgtat     1320

ggaaggttca caatcaagtc tgacgtatgg tcttttggaa tcttactcac agagctggtc     1380

accaaaggaa gagtgccata cccaggcatg aacaaccggg aggtgctgga gcaggtggag     1440

agaggctata ggatgccctg cccacaggac tgcccgatct ccctgcacga gctcatgatc     1500

cactgctgga aaaaggatcc ggaagagcgc ccgaccttcg agtacttgca gggcttcctg     1560

gaggactact ttacggccac agagccccag tatcagcccg gtgaaaacct gtga           1614


<210>  210
<211>  1605
<212>  DNA
<213>  Mus musculus

<400>  210
atgggctgtg tgcaatgtaa ggataaagaa gcagcgaaac tgacagagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggcg tgacctccat cccgaactac aacaacttcc acgcagctgg gggccaggga      180

ctcaccgtct ttgggggtgt gaactcctcc tctcacactg ggaccctacg cacgagagga      240

gggacaggag tgacactgtt tgtggcgctt tatgactatg aagcacggac ggaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agactggtgg      360

gaagcccgct ccttgacaac cggggaaact ggttacattc ccagcaatta cgtggctcca      420

gttgactcca tccaggcaga agagtggtac tttggaaaac ttggccgcaa agatgctgag      480

agacagctcc tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagcgaaacc      540

accaaaggtg cctactcact ttccatccgt gattgggatg atatgaaagg ggaccacgtc      600

aaacattata aaatccgcaa gcttgacaat ggtggatact atatcacaac gcgggcccag      660

tttgaaacac ttcagcaact ggtacagcat tactcagaga aagctgatgg tttgtgtttt      720

aacttaactg tggtttcatc aagttgtacc ccacaaactt ctggattggc taaagatgct      780

tgggaagttg cacgtgactc gttgtttctg gagaagaagc tggggcaggg gtgtttcgct      840

gaagtgtggc ttggtacctg gaatggaaat acaaaagtag ccataaagac ccttaagcca      900

ggcaccatgt ctccggagtc cttcctggag gaggcgcaga tcatgaagaa gctgaagcat      960

gacaagctgg tgcagctcta cgcggtcgtg tctgaggagc ccatttacat cgtcacggag     1020

tacatgagca aaggaagttt gcttgacttc ttaaaagatg gtgaaggaag agctctgaag     1080

ttgccaaacc ttgtggacat ggcggcacag gttgctgcag gaatggctta catcgagcgc     1140

atgaattata tccacagaga tctgcgatca gcaaacattc tagtggggaa tggactaatt     1200

tgcaagattg ctgactttgg attggctcgg ttgattgaag acaatgaata cacagcaaga     1260

caaggtgcga agtttcccat taagtggaca gcccccgaag cggccctgta tggaaggttc     1320

acaatcaagt ctgacgtatg gtcttttgga atcttactca cagagctggt caccaaagga     1380

agagtgccat acccaggcat gaacaaccgg gaggtgctgg agcaggtgga gagaggctat     1440

aggatgccct gcccacagga ctgcccgatc tccctgcacg agctcatgat ccactgctgg     1500

aaaaaggatc cggaagagcg cccgaccttc gagtacttgc agggcttcct ggaggactac     1560

tttacggcca cagagcccca gtatcagccc ggtgaaaacc tgtga                     1605


<210>  211
<211>  1605
<212>  DNA
<213>  Mus musculus

<400>  211
atgggctgtg tgcaatgtaa ggataaagaa gcagcgaaac tgacagagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggcg tgacctccat cccgaactac aacaacttcc acgcagctgg gggccaggga      180

ctcaccgtct ttgggggtgt gaactcctcc tctcacactg ggaccctacg cacgagagga      240

gggacaggag tgacactgtt tgtggcgctt tatgactatg aagcacggac ggaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agactggtgg      360

gaagcccgct ccttgacaac cggggaaact ggttacattc ccagcaatta cgtggctcca      420

gttgactcca tccaggcaga agagtggtac tttggaaaac ttggccgcaa agatgctgag      480

agacagctcc tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagcgaaacc      540

accaaaggtg cctactcact ttccatccgt gattgggatg atatgaaagg ggaccacgtc      600

aaacattata aaatccgcaa gcttgacaat ggtggatact atatcacaac gcgggcccag      660

tttgaaacac ttcagcaact ggtacagcat tactcagaga aagctgatgg tttgtgtttt      720

aacttaactg tggtttcatc aagttgtacc ccacaaactt ctggattggc taaagatgct      780

tgggaagttg cacgtgactc gttgtttctg gagaagaagc tggggcaggg gtgtttcgct      840

gaagtgtggc ttggtacctg gaatggaaat acaaaagtag ccataaagac ccttaagcca      900

ggcaccatgt ctccggagtc cttcctggag gaggcgcaga tcatgaagaa gctgaagcat      960

gacaagctgg tgcagctcta cgcggtcgtg tctgaggagc ccatttacat cgtcacggag     1020

tacatgagca aaggaagttt gcttgacttc ttaaaagatg gtgaaggaag agctctgaag     1080

ttgccaaacc ttgtggacat ggcggcacag gttgctgcag gaatggctta catcgagcgc     1140

atgaattata tccacagaga tctgcgatca gcaaacattc tagtggggaa tggactaatt     1200

tgcaagattg ctgactttgg attggctcgg ttgattgaag acaatgaata cacagcaaga     1260

caaggtgcga agtttcccat taagtggaca gcccccgaag cggccctgta tggaaggttc     1320

acaatcaagt ctgacgtatg gtcttttgga atcttactca cagagctggt caccaaagga     1380

agagtgccat acccaggcat gaacaaccgg gaggtgctgg agcaggtgga gagaggctat     1440

aggatgccct gcccacagga ctgcccgatc tccctgcacg agctcatgat ccactgctgg     1500

aaaaaggatc cggaagagcg cccgaccttc gagtacttgc agggcttcct ggaggactac     1560

tttacggcca cagagcccca gtatcagccc ggtgaaaacc tgtga                     1605


<210>  212
<211>  537
<212>  PRT
<213>  Mus musculus

<400>  212

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Ala Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Gly Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  213
<211>  534
<212>  PRT
<213>  Mus musculus

<400>  213

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Ala Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Lys Ala Asp Gly Leu Cys Phe 
225                 230                 235                 240 


Asn Leu Thr Val Val Ser Ser Ser Cys Thr Pro Gln Thr Ser Gly Leu 
                245                 250                 255     


Ala Lys Asp Ala Trp Glu Val Ala Arg Asp Ser Leu Phe Leu Glu Lys 
            260                 265                 270         


Lys Leu Gly Gln Gly Cys Phe Ala Glu Val Trp Leu Gly Thr Trp Asn 
        275                 280                 285             


Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser 
    290                 295                 300                 


Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His 
305                 310                 315                 320 


Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr 
                325                 330                 335     


Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            340                 345                 350         


Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala 
        355                 360                 365             


Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile 
    370                 375                 380                 


His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile 
385                 390                 395                 400 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
                405                 410                 415     


Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            420                 425                 430         


Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser 
        435                 440                 445             


Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr 
    450                 455                 460                 


Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr 
465                 470                 475                 480 


Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met 
                485                 490                 495     


Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr 
            500                 505                 510         


Leu Gln Gly Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr 
        515                 520                 525             


Gln Pro Gly Glu Asn Leu 
    530                 


<210>  214
<211>  534
<212>  PRT
<213>  Mus musculus

<400>  214

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Ala Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Lys Ala Asp Gly Leu Cys Phe 
225                 230                 235                 240 


Asn Leu Thr Val Val Ser Ser Ser Cys Thr Pro Gln Thr Ser Gly Leu 
                245                 250                 255     


Ala Lys Asp Ala Trp Glu Val Ala Arg Asp Ser Leu Phe Leu Glu Lys 
            260                 265                 270         


Lys Leu Gly Gln Gly Cys Phe Ala Glu Val Trp Leu Gly Thr Trp Asn 
        275                 280                 285             


Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser 
    290                 295                 300                 


Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His 
305                 310                 315                 320 


Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr 
                325                 330                 335     


Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            340                 345                 350         


Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala 
        355                 360                 365             


Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile 
    370                 375                 380                 


His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile 
385                 390                 395                 400 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
                405                 410                 415     


Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            420                 425                 430         


Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser 
        435                 440                 445             


Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr 
    450                 455                 460                 


Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr 
465                 470                 475                 480 


Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met 
                485                 490                 495     


Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr 
            500                 505                 510         


Leu Gln Gly Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr 
        515                 520                 525             


Gln Pro Gly Glu Asn Leu 
    530                 


<210>  215
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  215
atgggctgtg gctgcagctc acacccggaa gatgactgga tggaaaacat cgatgtgtgt       60

gagaactgcc attatcccat agtcccactg gatggcaagg gcacgctgct catccgaaat      120

ggctctgagg tgcgggaccc actggttacc tacgaaggct ccaatccgcc ggcttcccca      180

ctgcaagaca acctggttat cgctctgcac agctatgagc cctctcacga cggagatctg      240

ggctttgaga agggggaaca gctccgcatc ctggagcaga gcggcgagtg gtggaaggcg      300

cagtccctga ccacgggcca ggaaggcttc atccccttca attttgtggc caaagcgaac      360

agcctggagc ccgaaccctg gttcttcaag aacctgagcc gcaaggacgc ggagcggcag      420

ctcctggcgc ccgggaacac tcacggctcc ttcctcatcc gggagagcga gagcaccgcg      480

ggatcgtttt cactgtcggt ccgggacttc gaccagaacc agggagaggt ggtgaaacat      540

tacaagatcc gtaatctgga caacggtggc ttctacatct cccctcgaat cacttttccc      600

ggcctgcatg aactggtccg ccattacacc aatgcttcag atgggctgtg cacacggttg      660

agccgcccct gccagaccca gaagccccag aagccgtggt gggaggacga gtgggaggtt      720

cccagggaga cgctgaagct ggtggagcgg ctgggggctg gacagttcgg ggaggtgtgg      780

atggggtact acaacgggca cacgaaggtg gcggtgaaga gcctgaagca gggcagcatg      840

tccccggacg ccttcctggc cgaggccaac ctcatgaagc agctgcaaca ccagcggctg      900

gttcggctct acgctgtggt cacccaggag cccatctaca tcatcactga atacatggag      960

aatgggagtc tagtggattt tctcaagacc ccttcaggca tcaagttgac catcaacaaa     1020

ctcctggaca tggcagccca aattgcagaa ggcatggcat tcattgaaga gcggaattat     1080

attcatcgtg accttcgggc tgccaacatt ctggtgtctg acaccctgag ctgcaagatt     1140

gcagactttg gcctagcacg cctcattgag gacaacgagt acacagccag ggagggggcc     1200

aagtttccca ttaagtggac agcgccagaa gccattaact acgggacatt caccatcaag     1260

tcagatgtgt ggtcttttgg gatcctgctg acggaaattg tcacccacgg ccgcatccct     1320

tacccaggga tgaccaaccc ggaggtgatt cagaacctgg agcgaggcta ccgcatggtg     1380

cgccctgaca actgtccaga ggagctgtac caactcatga ggctgtgctg gaaggagcgc     1440

ccagaggacc ggcccacctt tgactacctg cgcagtgtgc tggaggactt cttcacggcc     1500

acagagggcc agtaccagcc tcagccttga                                      1530


<210>  216
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  216
atgggctgtg gctgcagctc acacccggaa gatgactgga tggaaaacat cgatgtgtgt       60

gagaactgcc attatcccat agtcccactg gatggcaagg gcacgctgct catccgaaat      120

ggctctgagg tgcgggaccc actggttacc tacgaaggct ccaatccgcc ggcttcccca      180

ctgcaagaca acctggttat cgctctgcac agctatgagc cctctcacga cggagatctg      240

ggctttgaga agggggaaca gctccgcatc ctggagcaga gcggcgagtg gtggaaggcg      300

cagtccctga ccacgggcca ggaaggcttc atccccttca attttgtggc caaagcgaac      360

agcctggagc ccgaaccctg gttcttcaag aacctgagcc gcaaggacgc ggagcggcag      420

ctcctggcgc ccgggaacac tcacggctcc ttcctcatcc gggagagcga gagcaccgcg      480

ggatcgtttt cactgtcggt ccgggacttc gaccagaacc agggagaggt ggtgaaacat      540

tacaagatcc gtaatctgga caacggtggc ttctacatct cccctcgaat cacttttccc      600

ggcctgcatg aactggtccg ccattacacc aatgcttcag atgggctgtg cacacggttg      660

agccgcccct gccagaccca gaagccccag aagccgtggt gggaggacga gtgggaggtt      720

cccagggaga cgctgaagct ggtggagcgg ctgggggctg gacagttcgg ggaggtgtgg      780

atggggtact acaacgggca cacgaaggtg gcggtgaaga gcctgaagca gggcagcatg      840

tccccggacg ccttcctggc cgaggccaac ctcatgaagc agctgcaaca ccagcggctg      900

gttcggctct acgctgtggt cacccaggag cccatctaca tcatcactga atacatggag      960

aatgggagtc tagtggattt tctcaagacc ccttcaggca tcaagttgac catcaacaaa     1020

ctcctggaca tggcagccca aattgcagaa ggcatggcat tcattgaaga gcggaattat     1080

attcatcgtg accttcgggc tgccaacatt ctggtgtctg acaccctgag ctgcaagatt     1140

gcagactttg gcctagcacg cctcattgag gacaacgagt acacagccag ggagggggcc     1200

aagtttccca ttaagtggac agcgccagaa gccattaact acgggacatt caccatcaag     1260

tcagatgtgt ggtcttttgg gatcctgctg acggaaattg tcacccacgg ccgcatccct     1320

tacccaggga tgaccaaccc ggaggtgatt cagaacctgg agcgaggcta ccgcatggtg     1380

cgccctgaca actgtccaga ggagctgtac caactcatga ggctgtgctg gaaggagcgc     1440

ccagaggacc ggcccacctt tgactacctg cgcagtgtgc tggaggactt cttcacggcc     1500

acagagggcc agtaccagcc tcagccttga                                      1530


<210>  217
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  218
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  219
<211>  1563
<212>  DNA
<213>  Mus musculus

<400>  219
atgggggcct ctgagctgac gatctcgggg atcatgggct gtgtctgcag ctcaaaccct       60

gaagatgact ggatggagaa cattgacgtg tgtgaaaact gccactatcc catagtccca      120

ctggacagca agatctcgct gcccatccgg aatggctctg aagtgcggga cccactggtc      180

acctatgagg gatctctccc accagcatcc ccgctgcaag acaacctggt tatcgccctg      240

cacagttatg agccctccca tgatggagac ttgggctttg agaagggtga acagctccga      300

atcctggagc agagcggtga gtggtggaag gctcagtccc tgacgactgg ccaagaaggc      360

ttcattccct tcaacttcgt ggcgaaagca aacagcctgg agcctgaacc ttggttcttc      420

aagaatctga gccgtaagga cgccgagcgg cagcttttgg cgcccgggaa cacgcatgga      480

tccttcctga tccgggaaag cgaaagcact gcggggtcct tttccctgtc ggtcagagac      540

ttcgaccaga accagggaga agtggtgaaa cattacaaga tccgtaacct agacaacggt      600

ggcttctaca tctcccctcg tatcactttt cccggattgc acgatctagt ccgccattac      660

accaacgcct ctgatgggct gtgcacaaag ttgagccgtc cttgccagac ccagaagccc      720

cagaaaccat ggtgggagga cgaatgggaa gttcccaggg aaacactgaa gttggtggag      780

cggctgggag ctggccagtt cggggaagtg tggatggggt actacaacgg acacacgaag      840

gtggcggtga agagtctgaa acaagggagc atgtcccccg acgccttcct ggctgaggct      900

aacctcatga agcagctgca gcacccgcgg ctagtccggc tttatgcagt ggtcacccag      960

gaacccatct acatcatcac ggaatacatg gagaacggga gcctagtaga ttttctcaag     1020

actccctcgg gcatcaagtt gaatgtcaac aaacttttgg acatggcagc ccagattgca     1080

gagggcatgg cgttcatcga agaacagaat tacatccatc gggacctgcg cgccgccaac     1140

atcctggtgt ctgacacgct gagctgcaag attgcagact ttggcctggc gcgcctcatt     1200

gaggacaatg agtacacggc ccgggagggg gccaaatttc ccattaagtg gacagcacca     1260

gaagccatta actatgggac cttcaccatc aagtcagacg tgtggtcctt cgggatcttg     1320

cttacagaga tcgtcaccca cggtcgaatc ccttacccag gaatgaccaa ccctgaagtc     1380

attcagaacc tggagagagg ctaccgcatg gtgagacctg acaactgtcc ggaagagctg     1440

taccacctca tgatgctgtg ctggaaggag cgcccagagg accggcccac gtttgactac     1500

cttcggagtg ttctggatga cttcttcaca gccacagagg gccagtacca gccccagcct     1560

tga                                                                   1563


<210>  220
<211>  1530
<212>  DNA
<213>  Mus musculus

<400>  220
atgggctgtg tctgcagctc aaaccctgaa gatgactgga tggagaacat tgacgtgtgt       60

gaaaactgcc actatcccat agtcccactg gacagcaaga tctcgctgcc catccggaat      120

ggctctgaag tgcgggaccc actggtcacc tatgagggat ctctcccacc agcatccccg      180

ctgcaagaca acctggttat cgccctgcac agttatgagc cctcccatga tggagacttg      240

ggctttgaga agggtgaaca gctccgaatc ctggagcaga gcggtgagtg gtggaaggct      300

cagtccctga cgactggcca agaaggcttc attcccttca acttcgtggc gaaagcaaac      360

agcctggagc ctgaaccttg gttcttcaag aatctgagcc gtaaggacgc cgagcggcag      420

cttttggcgc ccgggaacac gcatggatcc ttcctgatcc gggaaagcga aagcactgcg      480

gggtcctttt ccctgtcggt cagagacttc gaccagaacc agggagaagt ggtgaaacat      540

tacaagatcc gtaacctaga caacggtggc ttctacatct cccctcgtat cacttttccc      600

ggattgcacg atctagtccg ccattacacc aacgcctctg atgggctgtg cacaaagttg      660

agccgtcctt gccagaccca gaagccccag aaaccatggt gggaggacga atgggaagtt      720

cccagggaaa cactgaagtt ggtggagcgg ctgggagctg gccagttcgg ggaagtgtgg      780

atggggtact acaacggaca cacgaaggtg gcggtgaaga gtctgaaaca agggagcatg      840

tcccccgacg ccttcctggc tgaggctaac ctcatgaagc agctgcagca cccgcggcta      900

gtccggcttt atgcagtggt cacccaggaa cccatctaca tcatcacgga atacatggag      960

aacgggagcc tagtagattt tctcaagact ccctcgggca tcaagttgaa tgtcaacaaa     1020

cttttggaca tggcagccca gattgcagag ggcatggcgt tcatcgaaga acagaattac     1080

atccatcggg acctgcgcgc cgccaacatc ctggtgtctg acacgctgag ctgcaagatt     1140

gcagactttg gcctggcgcg cctcattgag gacaatgagt acacggcccg ggagggggcc     1200

aaatttccca ttaagtggac agcaccagaa gccattaact atgggacctt caccatcaag     1260

tcagacgtgt ggtccttcgg gatcttgctt acagagatcg tcacccacgg tcgaatccct     1320

tacccaggaa tgaccaaccc tgaagtcatt cagaacctgg agagaggcta ccgcatggtg     1380

agacctgaca actgtccgga agagctgtac cacctcatga tgctgtgctg gaaggagcgc     1440

ccagaggacc ggcccacgtt tgactacctt cggagtgttc tggatgactt cttcacagcc     1500

acagagggcc agtaccagcc ccagccttga                                      1530


<210>  221
<211>  1530
<212>  DNA
<213>  Mus musculus

<400>  221
atgggctgtg tctgcagctc aaaccctgaa gatgactgga tggagaacat tgacgtgtgt       60

gaaaactgcc actatcccat agtcccactg gacagcaaga tctcgctgcc catccggaat      120

ggctctgaag tgcgggaccc actggtcacc tatgagggat ctctcccacc agcatccccg      180

ctgcaagaca acctggttat cgccctgcac agttatgagc cctcccatga tggagacttg      240

ggctttgaga agggtgaaca gctccgaatc ctggagcaga gcggtgagtg gtggaaggct      300

cagtccctga cgactggcca agaaggcttc attcccttca acttcgtggc gaaagcaaac      360

agcctggagc ctgaaccttg gttcttcaag aatctgagcc gtaaggacgc cgagcggcag      420

cttttggcgc ccgggaacac gcatggatcc ttcctgatcc gggaaagcga aagcactgcg      480

gggtcctttt ccctgtcggt cagagacttc gaccagaacc agggagaagt ggtgaaacat      540

tacaagatcc gtaacctaga caacggtggc ttctacatct cccctcgtat cacttttccc      600

ggattgcacg atctagtccg ccattacacc aacgcctctg atgggctgtg cacaaagttg      660

agccgtcctt gccagaccca gaagccccag aaaccatggt gggaggacga atgggaagtt      720

cccagggaaa cactgaagtt ggtggagcgg ctgggagctg gccagttcgg ggaagtgtgg      780

atggggtact acaacggaca cacgaaggtg gcggtgaaga gtctgaaaca agggagcatg      840

tcccccgacg ccttcctggc tgaggctaac ctcatgaagc agctgcagca cccgcggcta      900

gtccggcttt atgcagtggt cacccaggaa cccatctaca tcatcacgga atacatggag      960

aacgggagcc tagtagattt tctcaagact ccctcgggca tcaagttgaa tgtcaacaaa     1020

cttttggaca tggcagccca gattgcagag ggcatggcgt tcatcgaaga acagaattac     1080

atccatcggg acctgcgcgc cgccaacatc ctggtgtctg acacgctgag ctgcaagatt     1140

gcagactttg gcctggcgcg cctcattgag gacaatgagt acacggcccg ggagggggcc     1200

aaatttccca ttaagtggac agcaccagaa gccattaact atgggacctt caccatcaag     1260

tcagacgtgt ggtccttcgg gatcttgctt acagagatcg tcacccacgg tcgaatccct     1320

tacccaggaa tgaccaaccc tgaagtcatt cagaacctgg agagaggcta ccgcatggtg     1380

agacctgaca actgtccgga agagctgtac cacctcatga tgctgtgctg gaaggagcgc     1440

ccagaggacc ggcccacgtt tgactacctt cggagtgttc tggatgactt cttcacagcc     1500

acagagggcc agtaccagcc ccagccttga                                      1530


<210>  222
<211>  520
<212>  PRT
<213>  Mus musculus

<400>  222

Met Gly Ala Ser Glu Leu Thr Ile Ser Gly Ile Met Gly Cys Val Cys 
1               5                   10                  15      


Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn Ile Asp Val Cys Glu 
            20                  25                  30          


Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser Lys Ile Ser Leu Pro 
        35                  40                  45              


Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu Val Thr Tyr Glu Gly 
    50                  55                  60                  


Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn Leu Val Ile Ala Leu 
65                  70                  75                  80  


His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu Gly Phe Glu Lys Gly 
                85                  90                  95      


Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu Trp Trp Lys Ala Gln 
            100                 105                 110         


Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro Phe Asn Phe Val Ala 
        115                 120                 125             


Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe Phe Lys Asn Leu Ser 
    130                 135                 140                 


Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Thr His Gly 
145                 150                 155                 160 


Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala Gly Ser Phe Ser Leu 
                165                 170                 175     


Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu Val Val Lys His Tyr 
            180                 185                 190         


Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg Ile 
        195                 200                 205             


Thr Phe Pro Gly Leu His Asp Leu Val Arg His Tyr Thr Asn Ala Ser 
    210                 215                 220                 


Asp Gly Leu Cys Thr Lys Leu Ser Arg Pro Cys Gln Thr Gln Lys Pro 
225                 230                 235                 240 


Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val Pro Arg Glu Thr Leu 
                245                 250                 255     


Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe Gly Glu Val Trp Met 
            260                 265                 270         


Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val Lys Ser Leu Lys Gln 
        275                 280                 285             


Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala Asn Leu Met Lys 
    290                 295                 300                 


Gln Leu Gln His Pro Arg Leu Val Arg Leu Tyr Ala Val Val Thr Gln 
305                 310                 315                 320 


Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu Val 
                325                 330                 335     


Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Asn Val Asn Lys Leu 
            340                 345                 350         


Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu Glu 
        355                 360                 365             


Gln Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser 
    370                 375                 380                 


Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile 
385                 390                 395                 400 


Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys 
                405                 410                 415     


Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe Thr Ile Lys Ser 
            420                 425                 430         


Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile Val Thr His Gly 
        435                 440                 445             


Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val Ile Gln Asn Leu 
    450                 455                 460                 


Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys Pro Glu Glu Leu 
465                 470                 475                 480 


Tyr His Leu Met Met Leu Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro 
                485                 490                 495     


Thr Phe Asp Tyr Leu Arg Ser Val Leu Asp Asp Phe Phe Thr Ala Thr 
            500                 505                 510         


Glu Gly Gln Tyr Gln Pro Gln Pro 
        515                 520 


<210>  223
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  223

Met Gly Cys Val Cys Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser 
            20                  25                  30          


Lys Ile Ser Leu Pro Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Asp Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Lys Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Pro Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Asn Val Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Gln Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr His Leu Met Met Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Asp Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  224
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  224

Met Gly Cys Val Cys Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser 
            20                  25                  30          


Lys Ile Ser Leu Pro Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Asp Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Lys Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Pro Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Asn Val Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Gln Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr His Leu Met Met Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Asp Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  225
<211>  1632
<212>  DNA
<213>  Homo sapiens

<400>  225
atgggctgca ttaaaagtaa agaaaacaaa agtccagcca ttaaatacag acctgaaaat       60

actccagagc ctgtcagtac aagtgtgagc cattatggag cagaacccac tacagtgtca      120

ccatgtccgt catcttcagc aaagggaaca gcagttaatt tcagcagtct ttccatgaca      180

ccatttggag gatcctcagg ggtaacgcct tttggaggtg catcttcctc attttcagtg      240

gtgccaagtt catatcctgc tggtttaaca ggtggtgtta ctatatttgt ggccttatat      300

gattatgaag ctagaactac agaagacctt tcatttaaga agggtgaaag atttcaaata      360

attaacaata cggaaggaga ttggtgggaa gcaagatcaa tcgctacagg aaagaatggt      420

tatatcccga gcaattatgt agcgcctgca gattccattc aggcagaaga atggtatttt      480

ggcaaaatgg ggagaaaaga tgctgaaaga ttacttttga atcctggaaa tcaacgaggt      540

attttcttag taagagagag tgaaacaact aaaggtgctt attccctttc tattcgtgat      600

tgggatgaga taaggggtga caatgtgaaa cactacaaaa ttaggaaact tgacaatggt      660

ggatactata tcacaaccag agcacaattt gatactctgc agaaattggt gaaacactac      720

acagaacatg ctgatggttt atgccacaag ttgacaactg tgtgtccaac tgtgaaacct      780

cagactcaag gtctagcaaa agatgcttgg gaaatccctc gagaatcttt gcgactagag      840

gttaaactag gacaaggatg tttcggcgaa gtgtggatgg gaacatggaa tggaaccacg      900

aaagtagcaa tcaaaacact aaaaccaggt acaatgatgc cagaagcttt ccttcaagaa      960

gctcagataa tgaaaaaatt aagacatgat aaacttgttc cactatatgc tgttgtttct     1020

gaagaaccaa tttacattgt cactgaattt atgtcaaaag gaagcttatt agatttcctt     1080

aaggaaggag atggaaagta tttgaagctt ccacagctgg ttgatatggc tgctcagatt     1140

gctgatggta tggcatatat tgaaagaatg aactatattc accgagatct tcgggctgct     1200

aatattcttg taggagaaaa tcttgtgtgc aaaatagcag actttggttt agcaaggtta     1260

attgaagaca atgaatacac agcaagacaa ggtgcaaaat ttccaatcaa atggacagct     1320

cctgaagctg cactgtatgg tcggtttaca ataaagtctg atgtctggtc atttggaatt     1380

ctgcaaacag aactagtaac aaagggccga gtgccatatc caggtatggt gaaccgtgaa     1440

gtactagaac aagtggagcg aggatacagg atgccgtgcc ctcagggctg tccagaatcc     1500

ctccatgaat tgatgaatct gtgttggaag aaggaccctg atgaaagacc aacatttgaa     1560

tatattcagt ccttcttgga agactacttc actgctacag agccacagta ccagccagga     1620

gaaaatttat aa                                                         1632


<210>  226
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210>  227
<211>  1626
<212>  DNA
<213>  Mus musculus

<400>  227
atgggctgca ttaaaagtaa agaaaacaaa agtccagcca taaaatacac accggaaaat       60

cttacagagc ctgtaagccc aagtgccagt cattatggag tggaacatgc tacagttgcc      120

ccgacctctt ccacaaaggg agcatcagtt aattttaaca gtctttccat gacacccttt      180

ggagggtcct caggggtgac tccttttgga ggagcgtctt cctcattctc agtggtgtca      240

agttcatatc ctacaggttt aacaggtggt gtcactatat ttgtggcctt gtatgattat      300

gaagctagaa ctacagaaga cctttccttt aagaagggtg aacgatttca aataattaac      360

aatacggaag gagactggtg ggaagcaaga tcaattgcta ccggaaagag tggttatatc      420

cctagcaatt acgtagtgcc tgcagattcc attcaggcag aagaatggta ttttggcaaa      480

atggggagaa aagatgcgga aagattactt ctgaatcctg ggaatcagcg aggtattttc      540

ttagtaagag aaagtgaaac tactaaaggt gcttactccc tctcaatccg tgattgggat      600

gaggtgaggg gtgacaatgt gaagcattac aagatcagaa aacttgacaa tggtggctac      660

tacatcacga ccagagctca gtttgataca ctgcagaagc tggtgaagca ctacacagaa      720

catgctgatg gattatgcca caagttaaca actgtgtgtc ctactgtgaa accccagact      780

caaggtctgg caaaagatgc ttgggaaatc cctcgagaat cattgcgact agaggtgaaa      840

ctaggtcaag gatgctttgg ggaagtgtgg atgggaacat ggaatggaac tacaaaagta      900

gcaatcaaaa cactaaagcc aggtacaatg atgccagaag cattccttca agaagctcag      960

ataatgaaaa agctaagaca cgataaactt gttccactct atgcagttgt ttctgaagag     1020

cccatttata ttgtcaccga gtttatgtca aaaggaagct tgttagattt ccttaaagaa     1080

ggagatggaa agtatttgaa gcttccacag ctggttgata tggctgctca gatcgctgat     1140

ggcatggcgt atattgaaag aatgaactat attcaccgag atctccgagc tgctaatatt     1200

cttgtaggag aaaatcttat atgcaaaata gcagattttg gcttagcaag attaattgaa     1260

gacaatgaat acacggcaag acaaggtgca aaatttccaa tcaagtggac agctcctgag     1320

gctgctctgt atggtcgatt tacaataaag tcagatgtgt ggtcatttgg aattctacag     1380

acagagctgg taacaaaagg aagagtgcca tatccaggta tggtaaaccg tgaagtattg     1440

gaacaagtag agcggggata cagaatgcct tgcccccagg gctgtcccga atccctccat     1500

gaattgatga atctttgctg gaagaaggat cctgatgaaa gaccaacatt tgaatatatt     1560

cagtccttct tggaagacta cttcactgct acagagccac agtaccaacc aggagaaaat     1620

ttataa                                                                1626


<210>  228
<211>  1626
<212>  DNA
<213>  Mus musculus

<400>  228
atgggctgca ttaaaagtaa agaaaacaaa agtccagcca taaaatacac accggaaaat       60

cttacagagc ctgtaagccc aagtgccagt cattatggag tggaacatgc tacagttgcc      120

ccgacctctt ccacaaaggg agcatcagtt aattttaaca gtctttccat gacacccttt      180

ggagggtcct caggggtgac tccttttgga ggagcgtctt cctcattctc agtggtgtca      240

agttcatatc ctacaggttt aacaggtggt gtcactatat ttgtggcctt gtatgattat      300

gaagctagaa ctacagaaga cctttccttt aagaagggtg aacgatttca aataattaac      360

aatacggaag gagactggtg ggaagcaaga tcaattgcta ccggaaagag tggttatatc      420

cctagcaatt acgtagtgcc tgcagattcc attcaggcag aagaatggta ttttggcaaa      480

atggggagaa aagatgcgga aagattactt ctgaatcctg ggaatcagcg aggtattttc      540

ttagtaagag aaagtgaaac tactaaaggt gcttactccc tctcaatccg tgattgggat      600

gaggtgaggg gtgacaatgt gaagcattac aagatcagaa aacttgacaa tggtggctac      660

tacatcacga ccagagctca gtttgataca ctgcagaagc tggtgaagca ctacacagaa      720

catgctgatg gattatgcca caagttaaca actgtgtgtc ctactgtgaa accccagact      780

caaggtctgg caaaagatgc ttgggaaatc cctcgagaat cattgcgact agaggtgaaa      840

ctaggtcaag gatgctttgg ggaagtgtgg atgggaacat ggaatggaac tacaaaagta      900

gcaatcaaaa cactaaagcc aggtacaatg atgccagaag cattccttca agaagctcag      960

ataatgaaaa agctaagaca cgataaactt gttccactct atgcagttgt ttctgaagag     1020

cccatttata ttgtcaccga gtttatgtca aaaggaagct tgttagattt ccttaaagaa     1080

ggagatggaa agtatttgaa gcttccacag ctggttgata tggctgctca gatcgctgat     1140

ggcatggcgt atattgaaag aatgaactat attcaccgag atctccgagc tgctaatatt     1200

cttgtaggag aaaatcttat atgcaaaata gcagattttg gcttagcaag attaattgaa     1260

gacaatgaat acacggcaag acaaggtgca aaatttccaa tcaagtggac agctcctgag     1320

gctgctctgt atggtcgatt tacaataaag tcagatgtgt ggtcatttgg aattctacag     1380

acagagctgg taacaaaagg aagagtgcca tatccaggta tggtaaaccg tgaagtattg     1440

gaacaagtag agcggggata cagaatgcct tgcccccagg gctgtcccga atccctccat     1500

gaattgatga atctttgctg gaagaaggat cctgatgaaa gaccaacatt tgaatatatt     1560

cagtccttct tggaagacta cttcactgct acagagccac agtaccaacc aggagaaaat     1620

ttataa                                                                1626


<210>  229
<211>  1626
<212>  DNA
<213>  Mus musculus

<400>  229
atgggctgca ttaaaagtaa agaaaacaaa agtccagcca taaaatacac accggaaaat       60

cttacagagc ctgtaagccc aagtgccagt cattatggag tggaacatgc tacagttgcc      120

ccgacctctt ccacaaaggg agcatcagtt aattttaaca gtctttccat gacacccttt      180

ggagggtcct caggggtgac tccttttgga ggagcgtctt cctcattctc agtggtgtca      240

agttcatatc ctacaggttt aacaggtggt gtcactatat ttgtggcctt gtatgattat      300

gaagctagaa ctacagaaga cctttccttt aagaagggtg aacgatttca aataattaac      360

aatacggaag gagactggtg ggaagcaaga tcaattgcta ccggaaagag tggttatatc      420

cctagcaatt acgtagtgcc tgcagattcc attcaggcag aagaatggta ttttggcaaa      480

atggggagaa aagatgcgga aagattactt ctgaatcctg ggaatcagcg aggtattttc      540

ttagtaagag aaagtgaaac tactaaaggt gcttactccc tctcaatccg tgattgggat      600

gaggtgaggg gtgacaatgt gaagcattac aagatcagaa aacttgacaa tggtggctac      660

tacatcacga ccagagctca gtttgataca ctgcagaagc tggtgaagca ctacacagaa      720

catgctgatg gattatgcca caagttaaca actgtgtgtc ctactgtgaa accccagact      780

caaggtctgg caaaagatgc ttgggaaatc cctcgagaat cattgcgact agaggtgaaa      840

ctaggtcaag gatgctttgg ggaagtgtgg atgggaacat ggaatggaac tacaaaagta      900

gcaatcaaaa cactaaagcc aggtacaatg atgccagaag cattccttca agaagctcag      960

ataatgaaaa agctaagaca cgataaactt gttccactct atgcagttgt ttctgaagag     1020

cccatttata ttgtcaccga gtttatgtca aaaggaagct tgttagattt ccttaaagaa     1080

ggagatggaa agtatttgaa gcttccacag ctggttgata tggctgctca gatcgctgat     1140

ggcatggcgt atattgaaag aatgaactat attcaccgag atctccgagc tgctaatatt     1200

cttgtaggag aaaatcttat atgcaaaata gcagattttg gcttagcaag attaattgaa     1260

gacaatgaat acacggcaag acaaggtgca aaatttccaa tcaagtggac agctcctgag     1320

gctgctctgt atggtcgatt tacaataaag tcagatgtgt ggtcatttgg aattctacag     1380

acagagctgg taacaaaagg aagagtgcca tatccaggta tggtaaaccg tgaagtattg     1440

gaacaagtag agcggggata cagaatgcct tgcccccagg gctgtcccga atccctccat     1500

gaattgatga atctttgctg gaagaaggat cctgatgaaa gaccaacatt tgaatatatt     1560

cagtccttct tggaagacta cttcactgct acagagccac agtaccaacc aggagaaaat     1620

ttataa                                                                1626


<210>  230
<211>  541
<212>  PRT
<213>  Mus musculus

<400>  230

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Thr Pro Glu Asn Leu Thr Glu Pro Val Ser Pro Ser Ala Ser His Tyr 
            20                  25                  30          


Gly Val Glu His Ala Thr Val Ala Pro Thr Ser Ser Thr Lys Gly Ala 
        35                  40                  45              


Ser Val Asn Phe Asn Ser Leu Ser Met Thr Pro Phe Gly Gly Ser Ser 
    50                  55                  60                  


Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val Val Ser 
65                  70                  75                  80  


Ser Ser Tyr Pro Thr Gly Leu Thr Gly Gly Val Thr Ile Phe Val Ala 
                85                  90                  95      


Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys 
            100                 105                 110         


Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu 
        115                 120                 125             


Ala Arg Ser Ile Ala Thr Gly Lys Ser Gly Tyr Ile Pro Ser Asn Tyr 
    130                 135                 140                 


Val Val Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys 
145                 150                 155                 160 


Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly Asn Gln 
                165                 170                 175     


Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr 
            180                 185                 190         


Ser Leu Ser Ile Arg Asp Trp Asp Glu Val Arg Gly Asp Asn Val Lys 
        195                 200                 205             


His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile Thr Thr 
    210                 215                 220                 


Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr Thr Glu 
225                 230                 235                 240 


His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro Thr Val 
                245                 250                 255     


Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg 
            260                 265                 270         


Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu 
        275                 280                 285             


Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile Lys Thr 
    290                 295                 300                 


Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu Ala Gln 
305                 310                 315                 320 


Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr Ala Val 
                325                 330                 335     


Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser Lys Gly 
            340                 345                 350         


Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu Lys Leu 
        355                 360                 365             


Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met Ala Tyr 
    370                 375                 380                 


Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile 
385                 390                 395                 400 


Leu Val Gly Glu Asn Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala 
                405                 410                 415     


Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu Leu Val 
    450                 455                 460                 


Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu 
465                 470                 475                 480 


Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly Cys Pro 
                485                 490                 495     


Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp Pro Asp 
            500                 505                 510         


Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp Tyr Phe 
        515                 520                 525             


Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540     


<210>  231
<211>  541
<212>  PRT
<213>  Mus musculus

<400>  231

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Thr Pro Glu Asn Leu Thr Glu Pro Val Ser Pro Ser Ala Ser His Tyr 
            20                  25                  30          


Gly Val Glu His Ala Thr Val Ala Pro Thr Ser Ser Thr Lys Gly Ala 
        35                  40                  45              


Ser Val Asn Phe Asn Ser Leu Ser Met Thr Pro Phe Gly Gly Ser Ser 
    50                  55                  60                  


Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val Val Ser 
65                  70                  75                  80  


Ser Ser Tyr Pro Thr Gly Leu Thr Gly Gly Val Thr Ile Phe Val Ala 
                85                  90                  95      


Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys 
            100                 105                 110         


Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu 
        115                 120                 125             


Ala Arg Ser Ile Ala Thr Gly Lys Ser Gly Tyr Ile Pro Ser Asn Tyr 
    130                 135                 140                 


Val Val Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys 
145                 150                 155                 160 


Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly Asn Gln 
                165                 170                 175     


Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr 
            180                 185                 190         


Ser Leu Ser Ile Arg Asp Trp Asp Glu Val Arg Gly Asp Asn Val Lys 
        195                 200                 205             


His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile Thr Thr 
    210                 215                 220                 


Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr Thr Glu 
225                 230                 235                 240 


His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro Thr Val 
                245                 250                 255     


Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg 
            260                 265                 270         


Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu 
        275                 280                 285             


Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile Lys Thr 
    290                 295                 300                 


Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu Ala Gln 
305                 310                 315                 320 


Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr Ala Val 
                325                 330                 335     


Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser Lys Gly 
            340                 345                 350         


Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu Lys Leu 
        355                 360                 365             


Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met Ala Tyr 
    370                 375                 380                 


Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile 
385                 390                 395                 400 


Leu Val Gly Glu Asn Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala 
                405                 410                 415     


Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu Leu Val 
    450                 455                 460                 


Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu 
465                 470                 475                 480 


Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly Cys Pro 
                485                 490                 495     


Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp Pro Asp 
            500                 505                 510         


Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp Tyr Phe 
        515                 520                 525             


Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540     


<210>  232
<211>  541
<212>  PRT
<213>  Mus musculus

<400>  232

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Thr Pro Glu Asn Leu Thr Glu Pro Val Ser Pro Ser Ala Ser His Tyr 
            20                  25                  30          


Gly Val Glu His Ala Thr Val Ala Pro Thr Ser Ser Thr Lys Gly Ala 
        35                  40                  45              


Ser Val Asn Phe Asn Ser Leu Ser Met Thr Pro Phe Gly Gly Ser Ser 
    50                  55                  60                  


Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val Val Ser 
65                  70                  75                  80  


Ser Ser Tyr Pro Thr Gly Leu Thr Gly Gly Val Thr Ile Phe Val Ala 
                85                  90                  95      


Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys 
            100                 105                 110         


Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu 
        115                 120                 125             


Ala Arg Ser Ile Ala Thr Gly Lys Ser Gly Tyr Ile Pro Ser Asn Tyr 
    130                 135                 140                 


Val Val Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys 
145                 150                 155                 160 


Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly Asn Gln 
                165                 170                 175     


Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr 
            180                 185                 190         


Ser Leu Ser Ile Arg Asp Trp Asp Glu Val Arg Gly Asp Asn Val Lys 
        195                 200                 205             


His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile Thr Thr 
    210                 215                 220                 


Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr Thr Glu 
225                 230                 235                 240 


His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro Thr Val 
                245                 250                 255     


Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg 
            260                 265                 270         


Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu 
        275                 280                 285             


Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile Lys Thr 
    290                 295                 300                 


Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu Ala Gln 
305                 310                 315                 320 


Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr Ala Val 
                325                 330                 335     


Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser Lys Gly 
            340                 345                 350         


Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu Lys Leu 
        355                 360                 365             


Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met Ala Tyr 
    370                 375                 380                 


Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile 
385                 390                 395                 400 


Leu Val Gly Glu Asn Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala 
                405                 410                 415     


Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu Leu Val 
    450                 455                 460                 


Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu 
465                 470                 475                 480 


Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly Cys Pro 
                485                 490                 495     


Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp Pro Asp 
            500                 505                 510         


Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp Tyr Phe 
        515                 520                 525             


Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540     


<210>  233
<211>  1539
<212>  DNA
<213>  Homo sapiens

<400>  233
atgggatgta taaaatcaaa agggaaagac agcttgagtg acgatggagt agatttgaag       60

actcaaccag tacgtaatac tgaaagaact atttatgtga gagatccaac gtccaataaa      120

cagcaaaggc cagttccaga atctcagctt ttacctggac agaggtttca aactaaagat      180

ccagaggaac aaggagacat tgtggtagcc ttgtacccct atgatggcat ccacccggac      240

gacttgtctt tcaagaaagg agagaagatg aaagtcctgg aggagcatgg agaatggtgg      300

aaagcaaagt cccttttaac aaaaaaagaa ggcttcatcc ccagcaacta tgtggccaaa      360

ctcaacacct tagaaacaga agagtggttt ttcaaggata taaccaggaa ggacgcagaa      420

aggcagcttt tggcaccagg aaatagcgct ggagctttcc ttattagaga aagtgaaaca      480

ttaaaaggaa gcttctctct gtctgtcaga gactttgacc ctgtgcatgg tgatgttatt      540

aagcactaca aaattagaag tctggataat gggggctatt acatctctcc acgaatcact      600

tttccctgta tcagcgacat gattaaacat taccaaaagc aggcagatgg cttgtgcaga      660

agattggaga aggcttgtat tagtcccaag ccacagaagc catgggataa agatgcctgg      720

gagatccccc gggagtccat caagttggtg aaaaggcttg gcgctgggca gtttggggaa      780

gtctggatgg gttactataa caacagtacc aaggtggctg tgaaaaccct gaagccagga      840

actatgtctg tgcaagcctt cctggaagaa gccaacctca tgaagaccct gcagcatgac      900

aagctcgtga ggctctacgc tgtggtcacc agggaggagc ccatttacat catcaccgag      960

tacatggcca agggcagttt gctggatttc ctgaagagcg atgaaggtgg caaagtgctg     1020

cttccaaagc tcattgactt ttctgctcag attgcagagg gaatggcata catcgagcgg     1080

aagaactaca ttcaccggga cctgcgagca gctaatgttc tggtctccga gtcactcatg     1140

tgcaaaattg cagattttgg ccttgctaga gtaattgaag ataatgagta cacagcaagg     1200

gaaggtgcta agttccctat taagtggacg gctccagaag caatcaactt tggatgtttc     1260

actattaagt ctgatgtgtg gtcctttgga atcctcctat acgaaattgt cacctatggg     1320

aaaattccct acccagggag aactaatgcc gacgtgatga ccgccctgtc ccagggctac     1380

aggatgcccc gtgtggagaa ctgcccagat gagctctatg acattatgaa aatgtgctgg     1440

aaagaaaagg cagaagagag accaacgttt gactacttac agagcgtcct ggatgatttc     1500

tacacagcca cggaagggca ataccagcag cagccttag                            1539


<210>  234
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  234
atgggatgta taaaatcaaa agggaaagac agcttgagtg acgatggagt agatttgaag       60

actcaaccag ttccagaatc tcagctttta cctggacaga ggtttcaaac taaagatcca      120

gaggaacaag gagacattgt ggtagccttg tacccctatg atggcatcca cccggacgac      180

ttgtctttca agaaaggaga gaagatgaaa gtcctggagg agcatggaga atggtggaaa      240

gcaaagtccc ttttaacaaa aaaagaaggc ttcatcccca gcaactatgt ggccaaactc      300

aacaccttag aaacagaaga gtggtttttc aaggatataa ccaggaagga cgcagaaagg      360

cagcttttgg caccaggaaa tagcgctgga gctttcctta ttagagaaag tgaaacatta      420

aaaggaagct tctctctgtc tgtcagagac tttgaccctg tgcatggtga tgttattaag      480

cactacaaaa ttagaagtct ggataatggg ggctattaca tctctccacg aatcactttt      540

ccctgtatca gcgacatgat taaacattac caaaagcagg cagatggctt gtgcagaaga      600

ttggagaagg cttgtattag tcccaagcca cagaagccat gggataaaga tgcctgggag      660

atcccccggg agtccatcaa gttggtgaaa aggcttggcg ctgggcagtt tggggaagtc      720

tggatgggtt actataacaa cagtaccaag gtggctgtga aaaccctgaa gccaggaact      780

atgtctgtgc aagccttcct ggaagaagcc aacctcatga agaccctgca gcatgacaag      840

ctcgtgaggc tctacgctgt ggtcaccagg gaggagccca tttacatcat caccgagtac      900

atggccaagg gcagtttgct ggatttcctg aagagcgatg aaggtggcaa agtgctgctt      960

ccaaagctca ttgacttttc tgctcagatt gcagagggaa tggcatacat cgagcggaag     1020

aactacattc accgggacct gcgagcagct aatgttctgg tctccgagtc actcatgtgc     1080

aaaattgcag attttggcct tgctagagta attgaagata atgagtacac agcaagggaa     1140

ggtgctaagt tccctattaa gtggacggct ccagaagcaa tcaactttgg atgtttcact     1200

attaagtctg atgtgtggtc ctttggaatc ctcctatacg aaattgtcac ctatgggaaa     1260

attccctacc cagggagaac taatgccgac gtgatgaccg ccctgtccca gggctacagg     1320

atgccccgtg tggagaactg cccagatgag ctctatgaca ttatgaaaat gtgctggaaa     1380

gaaaaggcag aagagagacc aacgtttgac tacttacaga gcgtcctgga tgatttctac     1440

acagccacgg aagggcaata ccagcagcag ccttag                               1476


<210>  235
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Arg Asn Thr Glu Arg Thr Ile Tyr 
            20                  25                  30          


Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro Val Pro Glu Ser 
        35                  40                  45              


Gln Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln 
    50                  55                  60                  


Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp 
65                  70                  75                  80  


Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val Leu Glu Glu His 
                85                  90                  95      


Gly Glu Trp Trp Lys Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe 
            100                 105                 110         


Ile Pro Ser Asn Tyr Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu 
        115                 120                 125             


Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu 
    130                 135                 140                 


Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr 
145                 150                 155                 160 


Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Pro Val His 
                165                 170                 175     


Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly 
            180                 185                 190         


Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile 
        195                 200                 205             


Lys His Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys 
    210                 215                 220                 


Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp 
225                 230                 235                 240 


Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly 
                245                 250                 255     


Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val 
            260                 265                 270         


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu 
        275                 280                 285             


Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg 
    290                 295                 300                 


Leu Tyr Ala Val Val Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu 
305                 310                 315                 320 


Tyr Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly 
                325                 330                 335     


Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala 
            340                 345                 350         


Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu 
        355                 360                 365             


Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
385                 390                 395                 400 


Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn 
                405                 410                 415     


Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
            420                 425                 430         


Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr 
        435                 440                 445             


Asn Ala Asp Val Met Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg 
    450                 455                 460                 


Val Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp 
465                 470                 475                 480 


Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val 
                485                 490                 495     


Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
            500                 505                 510         


<210>  236
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Pro Glu Ser Gln Leu Leu Pro Gly 
            20                  25                  30          


Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln Gly Asp Ile Val Val 
        35                  40                  45              


Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp Asp Leu Ser Phe Lys 
    50                  55                  60                  


Lys Gly Glu Lys Met Lys Val Leu Glu Glu His Gly Glu Trp Trp Lys 
65                  70                  75                  80  


Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe Ile Pro Ser Asn Tyr 
                85                  90                  95      


Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu Trp Phe Phe Lys Asp 
            100                 105                 110         


Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Ser 
        115                 120                 125             


Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Leu Lys Gly Ser Phe 
    130                 135                 140                 


Ser Leu Ser Val Arg Asp Phe Asp Pro Val His Gly Asp Val Ile Lys 
145                 150                 155                 160 


His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly Tyr Tyr Ile Ser Pro 
                165                 170                 175     


Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile Lys His Tyr Gln Lys 
            180                 185                 190         


Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys Ala Cys Ile Ser Pro 
        195                 200                 205             


Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp Glu Ile Pro Arg Glu 
    210                 215                 220                 


Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly Gln Phe Gly Glu Val 
225                 230                 235                 240 


Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val Ala Val Lys Thr Leu 
                245                 250                 255     


Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu Glu Glu Ala Asn Leu 
            260                 265                 270         


Met Lys Thr Leu Gln His Asp Lys Leu Val Arg Leu Tyr Ala Val Val 
        275                 280                 285             


Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Ala Lys Gly 
    290                 295                 300                 


Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Gly Lys Val Leu Leu 
305                 310                 315                 320 


Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr 
                325                 330                 335     


Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Val 
            340                 345                 350         


Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala Asp Phe Gly Leu Ala 
        355                 360                 365             


Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe 
    370                 375                 380                 


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Cys Phe Thr 
385                 390                 395                 400 


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Val 
                405                 410                 415     


Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr Asn Ala Asp Val Met 
            420                 425                 430         


Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg Val Glu Asn Cys Pro 
        435                 440                 445             


Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp Lys Glu Lys Ala Glu 
    450                 455                 460                 


Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr 
465                 470                 475                 480 


Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
                485                 490     


<210>  237
<211>  1539
<212>  DNA
<213>  Mus musculus

<400>  237
atgggatgta ttaaatcaaa aaggaaagac aatctcaatg acgatgaagt agattcgaag       60

actcaaccag tacgtaatac tgaccgaact atttatgtga gagatccaac gtccaataaa      120

cagcaaaggc cagttcctga atttcatctt ttaccaggac agagatttca aacaaaagat      180

ccagaggaac aaggtgacat tgtggtggcc ttataccctt atgatggcat ccacccagat      240

gacttgtcct tcaagaaagg agaaaagatg aaagttctag aagagcatgg ggaatggtgg      300

aaagctaagt ccctttcatc aaagagagaa ggcttcatcc ccagcaacta cgtggccaag      360

gtcaacacct tagaaactga agagtggttc ttcaaggaca taacaaggaa agatgcagag      420

cgacagcttc tggcaccagg gaacagtgca ggagctttcc ttatcagaga aagcgaaact      480

ttaaagggaa gcttctctct ttctgtcaga gattatgacc ctatgcatgg tgatgtcatt      540

aagcactaca aaattagaag tctggacaat ggtggctatt acatctctcc tcgcatcact      600

tttccctgca tcagtgacat gattaagcat taccaaaagc agtctgatgg tctatgcaga      660

agactggaga aggcatgcat cagtcccaaa cctcagaagc catgggataa agatgcctgg      720

gagatccccc gggagtccat taagttggtg aaaaagcttg gcgcagggca gtttggggaa      780

gtctggatgg gttactataa caacagcaca aaggtggctg tgaagaccct caagcccggc      840

accatgtctg tgcaggcatt cctggaagag gccaacctca tgaagacctt gcaacatgac      900

aagctagtgc ggctgtacgc tgtggtcacc aaggaggagc ccatctacat catcaccgag      960

ttcatggcta agggtagttt gctggatttc ctcaagagtg atgaaggtgg caaggtgctg     1020

ctgcccaagc tcattgactt ctcggcccag attgcagaag gcatggcgta catcgagcgg     1080

aagaactaca tccaccgtga tctgcgagct gctaacgtcc tggtctctga gtcactcatg     1140

tgcaagattg cagactttgg cctcgcgaga gtcatcgaag ataacgagta cacagcaagg     1200

gaaggtgcga agttccctat caagtggaca gctccagagg ccatcaactt cggctgcttc     1260

actatcaaat ctgacgtgtg gtccttcgga attctcctgt atgagattgt cacctatggg     1320

aagattccct acccagggag aaccaacgca gatgtgatga gcgcactgtc acagggatat     1380

cgaatgccac gcatggagaa ctgcccagat gagctctatg acatcatgaa aatgtgttgg     1440

aaagaaaagg cagaggagag gccaactttt gactacttac agagtgtcct ggatgacttc     1500

tatacagcca cagaagggca gtatcagcag caaccgtag                            1539


<210>  238
<211>  1476
<212>  DNA
<213>  Mus musculus

<400>  238
atgggatgta ttaaatcaaa aaggaaagac aatctcaatg acgatgaagt agattcgaag       60

actcaaccag ttcctgaatt tcatctttta ccaggacaga gatttcaaac aaaagatcca      120

gaggaacaag gtgacattgt ggtggcctta tacccttatg atggcatcca cccagatgac      180

ttgtccttca agaaaggaga aaagatgaaa gttctagaag agcatgggga atggtggaaa      240

gctaagtccc tttcatcaaa gagagaaggc ttcatcccca gcaactacgt ggccaaggtc      300

aacaccttag aaactgaaga gtggttcttc aaggacataa caaggaaaga tgcagagcga      360

cagcttctgg caccagggaa cagtgcagga gctttcctta tcagagaaag cgaaacttta      420

aagggaagct tctctctttc tgtcagagat tatgacccta tgcatggtga tgtcattaag      480

cactacaaaa ttagaagtct ggacaatggt ggctattaca tctctcctcg catcactttt      540

ccctgcatca gtgacatgat taagcattac caaaagcagt ctgatggtct atgcagaaga      600

ctggagaagg catgcatcag tcccaaacct cagaagccat gggataaaga tgcctgggag      660

atcccccggg agtccattaa gttggtgaaa aagcttggcg cagggcagtt tggggaagtc      720

tggatgggtt actataacaa cagcacaaag gtggctgtga agaccctcaa gcccggcacc      780

atgtctgtgc aggcattcct ggaagaggcc aacctcatga agaccttgca acatgacaag      840

ctagtgcggc tgtacgctgt ggtcaccaag gaggagccca tctacatcat caccgagttc      900

atggctaagg gtagtttgct ggatttcctc aagagtgatg aaggtggcaa ggtgctgctg      960

cccaagctca ttgacttctc ggcccagatt gcagaaggca tggcgtacat cgagcggaag     1020

aactacatcc accgtgatct gcgagctgct aacgtcctgg tctctgagtc actcatgtgc     1080

aagattgcag actttggcct cgcgagagtc atcgaagata acgagtacac agcaagggaa     1140

ggtgcgaagt tccctatcaa gtggacagct ccagaggcca tcaacttcgg ctgcttcact     1200

atcaaatctg acgtgtggtc cttcggaatt ctcctgtatg agattgtcac ctatgggaag     1260

attccctacc cagggagaac caacgcagat gtgatgagcg cactgtcaca gggatatcga     1320

atgccacgca tggagaactg cccagatgag ctctatgaca tcatgaaaat gtgttggaaa     1380

gaaaaggcag aggagaggcc aacttttgac tacttacaga gtgtcctgga tgacttctat     1440

acagccacag aagggcagta tcagcagcaa ccgtag                               1476


<210>  239
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  239

Met Gly Cys Ile Lys Ser Lys Arg Lys Asp Asn Leu Asn Asp Asp Glu 
1               5                   10                  15      


Val Asp Ser Lys Thr Gln Pro Val Arg Asn Thr Asp Arg Thr Ile Tyr 
            20                  25                  30          


Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro Val Pro Glu Phe 
        35                  40                  45              


His Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln 
    50                  55                  60                  


Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp 
65                  70                  75                  80  


Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val Leu Glu Glu His 
                85                  90                  95      


Gly Glu Trp Trp Lys Ala Lys Ser Leu Ser Ser Lys Arg Glu Gly Phe 
            100                 105                 110         


Ile Pro Ser Asn Tyr Val Ala Lys Val Asn Thr Leu Glu Thr Glu Glu 
        115                 120                 125             


Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu 
    130                 135                 140                 


Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr 
145                 150                 155                 160 


Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Tyr Asp Pro Met His 
                165                 170                 175     


Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly 
            180                 185                 190         


Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile 
        195                 200                 205             


Lys His Tyr Gln Lys Gln Ser Asp Gly Leu Cys Arg Arg Leu Glu Lys 
    210                 215                 220                 


Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp 
225                 230                 235                 240 


Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Lys Leu Gly Ala Gly 
                245                 250                 255     


Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val 
            260                 265                 270         


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu 
        275                 280                 285             


Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg 
    290                 295                 300                 


Leu Tyr Ala Val Val Thr Lys Glu Glu Pro Ile Tyr Ile Ile Thr Glu 
305                 310                 315                 320 


Phe Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly 
                325                 330                 335     


Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala 
            340                 345                 350         


Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu 
        355                 360                 365             


Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
385                 390                 395                 400 


Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn 
                405                 410                 415     


Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
            420                 425                 430         


Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr 
        435                 440                 445             


Asn Ala Asp Val Met Ser Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg 
    450                 455                 460                 


Met Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp 
465                 470                 475                 480 


Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val 
                485                 490                 495     


Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
            500                 505                 510         


<210>  240
<211>  491
<212>  PRT
<213>  Mus musculus

<400>  240

Met Gly Cys Ile Lys Ser Lys Arg Lys Asp Asn Leu Asn Asp Asp Glu 
1               5                   10                  15      


Val Asp Ser Lys Thr Gln Pro Val Pro Glu Phe His Leu Leu Pro Gly 
            20                  25                  30          


Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln Gly Asp Ile Val Val 
        35                  40                  45              


Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp Asp Leu Ser Phe Lys 
    50                  55                  60                  


Lys Gly Glu Lys Met Lys Val Leu Glu Glu His Gly Glu Trp Trp Lys 
65                  70                  75                  80  


Ala Lys Ser Leu Ser Ser Lys Arg Glu Gly Phe Ile Pro Ser Asn Tyr 
                85                  90                  95      


Val Ala Lys Val Asn Thr Leu Glu Thr Glu Glu Trp Phe Phe Lys Asp 
            100                 105                 110         


Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Ser 
        115                 120                 125             


Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Leu Lys Gly Ser Phe 
    130                 135                 140                 


Ser Leu Ser Val Arg Asp Tyr Asp Pro Met His Gly Asp Val Ile Lys 
145                 150                 155                 160 


His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly Tyr Tyr Ile Ser Pro 
                165                 170                 175     


Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile Lys His Tyr Gln Lys 
            180                 185                 190         


Gln Ser Asp Gly Leu Cys Arg Arg Leu Glu Lys Ala Cys Ile Ser Pro 
        195                 200                 205             


Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp Glu Ile Pro Arg Glu 
    210                 215                 220                 


Ser Ile Lys Leu Val Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val 
225                 230                 235                 240 


Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val Ala Val Lys Thr Leu 
                245                 250                 255     


Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu Glu Glu Ala Asn Leu 
            260                 265                 270         


Met Lys Thr Leu Gln His Asp Lys Leu Val Arg Leu Tyr Ala Val Val 
        275                 280                 285             


Thr Lys Glu Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly 
    290                 295                 300                 


Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Gly Lys Val Leu Leu 
305                 310                 315                 320 


Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr 
                325                 330                 335     


Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Val 
            340                 345                 350         


Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala Asp Phe Gly Leu Ala 
        355                 360                 365             


Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe 
    370                 375                 380                 


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Cys Phe Thr 
385                 390                 395                 400 


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Val 
                405                 410                 415     


Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr Asn Ala Asp Val Met 
            420                 425                 430         


Ser Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg Met Glu Asn Cys Pro 
        435                 440                 445             


Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp Lys Glu Lys Ala Glu 
    450                 455                 460                 


Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr 
465                 470                 475                 480 


Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
                485                 490     


<210>  241
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  241
atgggctgtg tgttctgcaa gaaattggag ccggtggcca cggccaagga ggatgctggc       60

ctggaagggg acttcagaag ctacggggca gcagaccact atgggcctga ccccactaag      120

gcccggcctg catcctcatt tgcccacatc cccaactaca gcaacttctc ctctcaggcc      180

atcaaccctg gcttccttga tagtggcacc atcaggggtg tgtcagggat tggggtgacc      240

ctgttcattg ccctgtatga ctatgaggct cgaactgagg atgacctcac cttcaccaag      300

ggcgagaagt tccacatcct gaacaatact gaaggtgact ggtgggaggc tcggtctctc      360

agctccggaa aaactggctg cattcccagc aactacgtgg cccctgttga ctcaatccaa      420

gctgaagagt ggtactttgg aaagattggg agaaaggatg cagagaggca gctgctttca      480

ccaggcaacc cccagggggc ctttctcatt cgggaaagcg agaccaccaa aggtgcctac      540

tccctgtcca tccgggactg ggatcagacc agaggcgatc atgtgaagca ttacaagatc      600

cgcaaactgg acatgggcgg ctactacatc accacacggg ttcagttcaa ctcggtgcag      660

gagctggtgc agcactacat ggaggtgaat gacgggctgt gcaacctgct catcgcgccc      720

tgcaccatca tgaagccgca gacgctgggc ctggccaagg acgcctggga gatcagccgc      780

agctccatca cgctggagcg ccggctgggc accggctgct tcggggatgt gtggctgggc      840

acgtggaacg gcagcactaa ggtggcggtg aagacgctga agccgggcac catgtccccg      900

aaggccttcc tggaggaggc gcaggtcatg aagctgctgc ggcacgacaa gctggtgcag      960

ctgtacgccg tggtgtcgga ggagcccatc tacatcgtga ccgagttcat gtgtcacggc     1020

agcttgctgg attttctcaa gaacccagag ggccaggatt tgaggctgcc ccaattggtg     1080

gacatggcag cccaggtagc tgagggcatg gcctacatgg aacgcatgaa ctacattcac     1140

cgcgacctga gggcagccaa catcctggtt ggggagcggc tggcgtgcaa gatcgcagac     1200

tttggcttgg cgcgtctcat caaggacgat gagtacaacc cctgccaagg ttccaagttc     1260

cccatcaagt ggacagcccc agaagctgcc ctctttggca gattcaccat caagtcagac     1320

gtgtggtcct ttgggatcct gctcactgag ctcatcacca agggccgaat cccctaccca     1380

ggcatgaata aacgggaagt gttggaacag gtggagcagg gctaccacat gccgtgccct     1440

ccaggctgcc cagcatccct gtacgaggcc atggaacaga cctggcgtct ggacccggag     1500

gagaggccta ccttcgagta cctgcagtcc ttcctggagg actacttcac ctccgctgaa     1560

ccacagtacc agcccgggga tcagacatag                                      1590


<210>  242
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  242
atgggctgtg tgttctgcaa gaaattggag ccggtggcca cggccaagga ggatgctggc       60

ctggaagggg acttcagaag ctacggggca gcagaccact atgggcctga ccccactaag      120

gcccggcctg catcctcatt tgcccacatc cccaactaca gcaacttctc ctctcaggcc      180

atcaaccctg gcttccttga tagtggcacc atcaggggtg tgtcagggat tggggtgacc      240

ctgttcattg ccctgtatga ctatgaggct cgaactgagg atgacctcac cttcaccaag      300

ggcgagaagt tccacatcct gaacaatact gaaggtgact ggtgggaggc tcggtctctc      360

agctccggaa aaactggctg cattcccagc aactacgtgg cccctgttga ctcaatccaa      420

gctgaagagt ggtactttgg aaagattggg agaaaggatg cagagaggca gctgctttca      480

ccaggcaacc cccagggggc ctttctcatt cgggaaagcg agaccaccaa aggtgcctac      540

tccctgtcca tccgggactg ggatcagacc agaggcgatc atgtgaagca ttacaagatc      600

cgcaaactgg acatgggcgg ctactacatc accacacggg ttcagttcaa ctcggtgcag      660

gagctggtgc agcactacat ggaggtgaat gacgggctgt gcaacctgct catcgcgccc      720

tgcaccatca tgaagccgca gacgctgggc ctggccaagg acgcctggga gatcagccgc      780

agctccatca cgctggagcg ccggctgggc accggctgct tcggggatgt gtggctgggc      840

acgtggaacg gcagcactaa ggtggcggtg aagacgctga agccgggcac catgtccccg      900

aaggccttcc tggaggaggc gcaggtcatg aagctgctgc ggcacgacaa gctggtgcag      960

ctgtacgccg tggtgtcgga ggagcccatc tacatcgtga ccgagttcat gtgtcacggc     1020

agcttgctgg attttctcaa gaacccagag ggccaggatt tgaggctgcc ccaattggtg     1080

gacatggcag cccaggtagc tgagggcatg gcctacatgg aacgcatgaa ctacattcac     1140

cgcgacctga gggcagccaa catcctggtt ggggagcggc tggcgtgcaa gatcgcagac     1200

tttggcttgg cgcgtctcat caaggacgat gagtacaacc cctgccaagg ttccaagttc     1260

cccatcaagt ggacagcccc agaagctgcc ctctttggca gattcaccat caagtcagac     1320

gtgtggtcct ttgggatcct gctcactgag ctcatcacca agggccgaat cccctaccca     1380

ggcatgaata aacgggaagt gttggaacag gtggagcagg gctaccacat gccgtgccct     1440

ccaggctgcc cagcatccct gtacgaggcc atggaacaga cctggcgtct ggacccggag     1500

gagaggccta ccttcgagta cctgcagtcc ttcctggagg actacttcac ctccgctgaa     1560

ccacagtacc agcccgggga tcagacatag                                      1590


<210>  243
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  243
atgggctgtg tgttctgcaa gaaattggag ccggtggcca cggccaagga ggatgctggc       60

ctggaagggg acttcagaag ctacggggca gcagaccact atgggcctga ccccactaag      120

gcccggcctg catcctcatt tgcccacatc cccaactaca gcaacttctc ctctcaggcc      180

atcaaccctg gcttccttga tagtggcacc atcaggggtg tgtcagggat tggggtgacc      240

ctgttcattg ccctgtatga ctatgaggct cgaactgagg atgacctcac cttcaccaag      300

ggcgagaagt tccacatcct gaacaatact gaaggtgact ggtgggaggc tcggtctctc      360

agctccggaa aaactggctg cattcccagc aactacgtgg cccctgttga ctcaatccaa      420

gctgaagagt ggtactttgg aaagattggg agaaaggatg cagagaggca gctgctttca      480

ccaggcaacc cccagggggc ctttctcatt cgggaaagcg agaccaccaa aggtgcctac      540

tccctgtcca tccgggactg ggatcagacc agaggcgatc atgtgaagca ttacaagatc      600

cgcaaactgg acatgggcgg ctactacatc accacacggg ttcagttcaa ctcggtgcag      660

gagctggtgc agcactacat ggaggtgaat gacgggctgt gcaacctgct catcgcgccc      720

tgcaccatca tgaagccgca gacgctgggc ctggccaagg acgcctggga gatcagccgc      780

agctccatca cgctggagcg ccggctgggc accggctgct tcggggatgt gtggctgggc      840

acgtggaacg gcagcactaa ggtggcggtg aagacgctga agccgggcac catgtccccg      900

aaggccttcc tggaggaggc gcaggtcatg aagctgctgc ggcacgacaa gctggtgcag      960

ctgtacgccg tggtgtcgga ggagcccatc tacatcgtga ccgagttcat gtgtcacggc     1020

agcttgctgg attttctcaa gaacccagag ggccaggatt tgaggctgcc ccaattggtg     1080

gacatggcag cccaggtagc tgagggcatg gcctacatgg aacgcatgaa ctacattcac     1140

cgcgacctga gggcagccaa catcctggtt ggggagcggc tggcgtgcaa gatcgcagac     1200

tttggcttgg cgcgtctcat caaggacgat gagtacaacc cctgccaagg ttccaagttc     1260

cccatcaagt ggacagcccc agaagctgcc ctctttggca gattcaccat caagtcagac     1320

gtgtggtcct ttgggatcct gctcactgag ctcatcacca agggccgaat cccctaccca     1380

ggcatgaata aacgggaagt gttggaacag gtggagcagg gctaccacat gccgtgccct     1440

ccaggctgcc cagcatccct gtacgaggcc atggaacaga cctggcgtct ggacccggag     1500

gagaggccta ccttcgagta cctgcagtcc ttcctggagg actacttcac ctccgctgaa     1560

ccacagtacc agcccgggga tcagacatag                                      1590


<210>  244
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210>  245
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210>  246
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210>  247
<211>  1554
<212>  DNA
<213>  Mus musculus

<400>  247
atgggctgtg tgttctgcaa gaagttggag cctgcatcca aggaggatgt gggcctggaa       60

ggggacttcc ggagccaaac ggctgaagaa cgctatttcc ctgaccccac tcaaggccgg      120

acttcgtccg tctttcctca gcccaccagc cctgctttcc tcaacactgg caacatgaga      180

agcatctcag ggaccggagt gaccatattc gtcgccctgt acgactatga ggccaggaca      240

ggggatgacc tcaccttcac caaaggcgag aagttccaca tcctgaacaa tacggagtat      300

gactggtggg aggctcgctc cctgagctcc ggacacagag gctatgttcc cagcaactat      360

gttgctcctg tggattccat ccaggctgaa gagtggtact tcggaaagat cagtagaaag      420

gatgcagaga ggcagcttct gtcctctggt aacccccagg gggcctttct cattcgggaa      480

agcgagacca ccaaaggggc ctactccctg tccatccgtg actgggacca gaacagaggc      540

gatcacataa agcattataa gatccgaaag ctggacacgg gcggctacta catcaccaca      600

cgggcccagt ttgactccat acaggaccta gtgcggcact acatggaagt gaatgatggt      660

ctgtgctact tgcttacggc gccttgtacc accactaagc cccagactct aggcctggcc      720

aaggatgcct gggagatcga ccggaactcc atagcactgg aacgcaggct gggcaccggc      780

tgctttggag atgtgtggct gggcacatgg aactgcagca caaaggtggc agtgaagacg      840

ctgaagccgg gcaccatgtc cccgaaggca ttcctggagg aggcacagat catgaagctg      900

ctgaggcacg acaagctggt gcagctgtat gcggtggtgt cggaggaacc catttatatt      960

gtgacagagt tcatgtgcta tggtagcttg ctggatttcc taaaggatcg agaaggtcag     1020

aacttgatgc tgccccatct agtggacatg gctgcccagg tagccgaggg catggcctac     1080

atggaacgca tgaactatat ccaccgagac ttgagggcag ccaacatcct ggtgggggaa     1140

tacctaatat gcaagatcgc tgacttcggg ctggcacgcc tcatagagga caatgagtat     1200

aacccccaac aaggaaccaa gttccccatc aagtggacag ccccagaggc cgccctcttt     1260

ggcagattca ctgtcaaatc agacgtgtgg tcctttggga ttctgctcac tgaactgatc     1320

accaagggca gagttcccta cccaggtatg aacaaccggg aagtgttgga acaggtggag     1380

catggctacc acatgccgtg ccctccagga tgtcctgcat ccctgtatga ggtcatggag     1440

caggcgtggc gcctggatcc agaggagagg cccacctttg agtacctgca gtctttcctg     1500

gaagactatt tcacctccac agaaccacag taccagcctg gagaccagac atag           1554


<210>  248
<211>  517
<212>  PRT
<213>  Mus musculus

<400>  248

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Ala Ser Lys Glu Asp 
1               5                   10                  15      


Val Gly Leu Glu Gly Asp Phe Arg Ser Gln Thr Ala Glu Glu Arg Tyr 
            20                  25                  30          


Phe Pro Asp Pro Thr Gln Gly Arg Thr Ser Ser Val Phe Pro Gln Pro 
        35                  40                  45              


Thr Ser Pro Ala Phe Leu Asn Thr Gly Asn Met Arg Ser Ile Ser Gly 
    50                  55                  60                  


Thr Gly Val Thr Ile Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr 
65                  70                  75                  80  


Gly Asp Asp Leu Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn 
                85                  90                  95      


Asn Thr Glu Tyr Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly His 
            100                 105                 110         


Arg Gly Tyr Val Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
        115                 120                 125             


Ala Glu Glu Trp Tyr Phe Gly Lys Ile Ser Arg Lys Asp Ala Glu Arg 
    130                 135                 140                 


Gln Leu Leu Ser Ser Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu 
145                 150                 155                 160 


Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp 
                165                 170                 175     


Gln Asn Arg Gly Asp His Ile Lys His Tyr Lys Ile Arg Lys Leu Asp 
            180                 185                 190         


Thr Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Asp Ser Ile Gln 
        195                 200                 205             


Asp Leu Val Arg His Tyr Met Glu Val Asn Asp Gly Leu Cys Tyr Leu 
    210                 215                 220                 


Leu Thr Ala Pro Cys Thr Thr Thr Lys Pro Gln Thr Leu Gly Leu Ala 
225                 230                 235                 240 


Lys Asp Ala Trp Glu Ile Asp Arg Asn Ser Ile Ala Leu Glu Arg Arg 
                245                 250                 255     


Leu Gly Thr Gly Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Cys 
            260                 265                 270         


Ser Thr Lys Val Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro 
        275                 280                 285             


Lys Ala Phe Leu Glu Glu Ala Gln Ile Met Lys Leu Leu Arg His Asp 
    290                 295                 300                 


Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile 
305                 310                 315                 320 


Val Thr Glu Phe Met Cys Tyr Gly Ser Leu Leu Asp Phe Leu Lys Asp 
                325                 330                 335     


Arg Glu Gly Gln Asn Leu Met Leu Pro His Leu Val Asp Met Ala Ala 
            340                 345                 350         


Gln Val Ala Glu Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His 
        355                 360                 365             


Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Tyr Leu Ile Cys 
    370                 375                 380                 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr 
385                 390                 395                 400 


Asn Pro Gln Gln Gly Thr Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu 
                405                 410                 415     


Ala Ala Leu Phe Gly Arg Phe Thr Val Lys Ser Asp Val Trp Ser Phe 
            420                 425                 430         


Gly Ile Leu Leu Thr Glu Leu Ile Thr Lys Gly Arg Val Pro Tyr Pro 
        435                 440                 445             


Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu His Gly Tyr His 
    450                 455                 460                 


Met Pro Cys Pro Pro Gly Cys Pro Ala Ser Leu Tyr Glu Val Met Glu 
465                 470                 475                 480 


Gln Ala Trp Arg Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu 
                485                 490                 495     


Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro Gln Tyr Gln 
            500                 505                 510         


Pro Gly Asp Gln Thr 
        515         


<210>  249
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  249
atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa       60

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      120

gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc      180

atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag      240

ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc      300

acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca      360

gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc      420

ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct      480

ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg      540

accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag      600

ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc      660

atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc      720

ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac      780

aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc      840

ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat      900

gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg      960

ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc     1020

tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac     1080

ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc     1140

ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc     1200

aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg     1260

tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg     1320

tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac     1380

tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg     1440

ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag     1500

taccaacagc agccatga                                                   1518


<210>  250
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  250
atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa       60

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      120

gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc      180

atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag      240

ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc      300

acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca      360

gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc      420

ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct      480

ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg      540

accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag      600

ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc      660

atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc      720

ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac      780

aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc      840

ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat      900

gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg      960

ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc     1020

tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac     1080

ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc     1140

ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc     1200

aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg     1260

tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg     1320

tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac     1380

tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg     1440

ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag     1500

taccaacagc agccatga                                                   1518


<210>  251
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  251
atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa       60

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      120

gggcctaata gccacaacag caacacacca ggaatcaggg agggctctga ggacatcatc      180

gtggttgccc tgtatgatta cgaggccatt caccacgaag acctcagctt ccagaagggg      240

gaccagatgg tggtcctaga ggaatccggg gagtggtgga aggctcgatc cctggccacc      300

cggaaggagg gctacatccc aagcaactat gtcgcccgcg ttgactctct ggagacagag      360

gagtggtttt tcaagggcat cagccggaag gacgcagagc gccaactgct ggctcccggc      420

aacatgctgg gctccttcat gatccgggat agcgagacca ctaaaggaag ctactctttg      480

tccgtgcgag actacgaccc tcggcaggga gataccgtga aacattacaa gatccggacc      540

ctggacaacg ggggcttcta catatccccc cgaagcacct tcagcactct gcaggagctg      600

gtggaccact acaagaaggg gaacgacggg ctctgccaga aactgtcggt gccctgcatg      660

tcttccaagc cccagaagcc ttgggagaaa gatgcctggg agatccctcg ggaatccctc      720

aagctggaga agaaacttgg agctgggcag tttggggaag tctggatggc cacctacaac      780

aagcacacca aggtggcagt gaagacgatg aagccaggga gcatgtcggt ggaggccttc      840

ctggcagagg ccaacgtgat gaaaactctg cagcatgaca agctggtcaa acttcatgcg      900

gtggtcacca aggagcccat ctacatcatc acggagttca tggccaaagg aagcttgctg      960

gactttctga aaagtgatga gggcagcaag cagccattgc caaaactcat tgacttctca     1020

gcccagattg cagaaggcat ggccttcatc gagcagagga actacatcca ccgagacctc     1080

cgagctgcca acatcttggt ctctgcatcc ctggtgtgta agattgctga ctttggcctg     1140

gcccgggtca ttgaggacaa cgagtacacg gctcgggaag gggccaagtt ccccatcaag     1200

tggacagctc ctgaagccat caactttggc tccttcacca tcaagtcaga cgtctggtcc     1260

tttggtatcc tgctgatgga gatcgtcacc tacggccgga tcccttaccc agggatgtca     1320

aaccctgaag tgatccgagc tctggagcgt ggataccgga tgcctcgccc agagaactgc     1380

ccagaggagc tctacaacat catgatgcgc tgctggaaaa accgtccgga ggagcggccg     1440

accttcgaat acatccagag tgtgctggat gacttctaca cggccacaga gagccagtac     1500

caacagcagc catga                                                      1515


<210>  252
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  252
atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa       60

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      120

gggcctaata gccacaacag caacacacca ggaatcaggg agggctctga ggacatcatc      180

gtggttgccc tgtatgatta cgaggccatt caccacgaag acctcagctt ccagaagggg      240

gaccagatgg tggtcctaga ggaatccggg gagtggtgga aggctcgatc cctggccacc      300

cggaaggagg gctacatccc aagcaactat gtcgcccgcg ttgactctct ggagacagag      360

gagtggtttt tcaagggcat cagccggaag gacgcagagc gccaactgct ggctcccggc      420

aacatgctgg gctccttcat gatccgggat agcgagacca ctaaaggaag ctactctttg      480

tccgtgcgag actacgaccc tcggcaggga gataccgtga aacattacaa gatccggacc      540

ctggacaacg ggggcttcta catatccccc cgaagcacct tcagcactct gcaggagctg      600

gtggaccact acaagaaggg gaacgacggg ctctgccaga aactgtcggt gccctgcatg      660

tcttccaagc cccagaagcc ttgggagaaa gatgcctggg agatccctcg ggaatccctc      720

aagctggaga agaaacttgg agctgggcag tttggggaag tctggatggc cacctacaac      780

aagcacacca aggtggcagt gaagacgatg aagccaggga gcatgtcggt ggaggccttc      840

ctggcagagg ccaacgtgat gaaaactctg cagcatgaca agctggtcaa acttcatgcg      900

gtggtcacca aggagcccat ctacatcatc acggagttca tggccaaagg aagcttgctg      960

gactttctga aaagtgatga gggcagcaag cagccattgc caaaactcat tgacttctca     1020

gcccagattg cagaaggcat ggccttcatc gagcagagga actacatcca ccgagacctc     1080

cgagctgcca acatcttggt ctctgcatcc ctggtgtgta agattgctga ctttggcctg     1140

gcccgggtca ttgaggacaa cgagtacacg gctcgggaag gggccaagtt ccccatcaag     1200

tggacagctc ctgaagccat caactttggc tccttcacca tcaagtcaga cgtctggtcc     1260

tttggtatcc tgctgatgga gatcgtcacc tacggccgga tcccttaccc agggatgtca     1320

aaccctgaag tgatccgagc tctggagcgt ggataccgga tgcctcgccc agagaactgc     1380

ccagaggagc tctacaacat catgatgcgc tgctggaaaa accgtccgga ggagcggccg     1440

accttcgaat acatccagag tgtgctggat gacttctaca cggccacaga gagccagtac     1500

caacagcagc catga                                                      1515


<210>  253
<211>  1521
<212>  DNA
<213>  Homo sapiens

<400>  253
atgatggggt gcatgaagtc caagttcctc caggtcggag gcaatacatt ctcaaaaact       60

gaaaccagcg ccagcccaca ctgtcctgtg tacgtgccgg atcccacatc caccatcaag      120

ccggggccta atagccacaa cagcaacaca ccaggaatca gggaggcagg ctctgaggac      180

atcatcgtgg ttgccctgta tgattacgag gccattcacc acgaagacct cagcttccag      240

aagggggacc agatggtggt cctagaggaa tccggggagt ggtggaaggc tcgatccctg      300

gccacccgga aggagggcta catcccaagc aactatgtcg cccgcgttga ctctctggag      360

acagaggagt ggtttttcaa gggcatcagc cggaaggacg cagagcgcca actgctggct      420

cccggcaaca tgctgggctc cttcatgatc cgggatagcg agaccactaa aggaagctac      480

tctttgtccg tgcgagacta cgaccctcgg cagggagata ccgtgaaaca ttacaagatc      540

cggaccctgg acaacggggg cttctacata tccccccgaa gcaccttcag cactctgcag      600

gagctggtgg accactacaa gaaggggaac gacgggctct gccagaaact gtcggtgccc      660

tgcatgtctt ccaagcccca gaagccttgg gagaaagatg cctgggagat ccctcgggaa      720

tccctcaagc tggagaagaa acttggagct gggcagtttg gggaagtctg gatggccacc      780

tacaacaagc acaccaaggt ggcagtgaag acgatgaagc cagggagcat gtcggtggag      840

gccttcctgg cagaggccaa cgtgatgaaa actctgcagc atgacaagct ggtcaaactt      900

catgcggtgg tcaccaagga gcccatctac atcatcacgg agttcatggc caaaggaagc      960

ttgctggact ttctgaaaag tgatgagggc agcaagcagc cattgccaaa actcattgac     1020

ttctcagccc agattgcaga aggcatggcc ttcatcgagc agaggaacta catccaccga     1080

gacctccgag ctgccaacat cttggtctct gcatccctgg tgtgtaagat tgctgacttt     1140

ggcctggccc gggtcattga ggacaacgag tacacggctc gggaaggggc caagttcccc     1200

atcaagtgga cagctcctga agccatcaac tttggctcct tcaccatcaa gtcagacgtc     1260

tggtcctttg gtatcctgct gatggagatc gtcacctacg gccggatccc ttacccaggg     1320

atgtcaaacc ctgaagtgat ccgagctctg gagcgtggat accggatgcc tcgcccagag     1380

aactgcccag aggagctcta caacatcatg atgcgctgct ggaaaaaccg tccggaggag     1440

cggccgacct tcgaatacat ccagagtgtg ctggatgact tctacacggc cacagagagc     1500

cagtaccaac agcagccatg a                                               1521


<210>  254
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  254
atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa       60

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      120

gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc      180

atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag      240

ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc      300

acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca      360

gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc      420

ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct      480

ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg      540

accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag      600

ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc      660

atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc      720

ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac      780

aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc      840

ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat      900

gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg      960

ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc     1020

tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac     1080

ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc     1140

ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc     1200

aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg     1260

tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg     1320

tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac     1380

tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg     1440

ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag     1500

taccaacagc agccatga                                                   1518


<210>  255
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp 
65                  70                  75                  80  


Ile Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp 
                85                  90                  95      


Leu Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly 
            100                 105                 110         


Glu Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp 
    130                 135                 140                 


Phe Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala 
145                 150                 155                 160 


Pro Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly 
            180                 185                 190         


Asp Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe 
        195                 200                 205             


Tyr Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp 
    210                 215                 220                 


His Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro 
225                 230                 235                 240 


Cys Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu 
                245                 250                 255     


Ile Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln 
            260                 265                 270         


Phe Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala 
        275                 280                 285             


Val Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala 
    290                 295                 300                 


Glu Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu 
305                 310                 315                 320 


His Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met 
                325                 330                 335     


Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys 
            340                 345                 350         


Gln Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly 
        355                 360                 365             


Met Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala 
    370                 375                 380                 


Ala Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe 
385                 390                 395                 400 


Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly 
                405                 410                 415     


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly 
            420                 425                 430         


Ser Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met 
        435                 440                 445             


Glu Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro 
    450                 455                 460                 


Glu Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu 
465                 470                 475                 480 


Asn Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn 
                485                 490                 495     


Arg Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp 
            500                 505                 510         


Asp Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 525     


<210>  256
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val Gly Gly Asn Thr Phe 
1               5                   10                  15      


Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys Pro Val Tyr Val Pro 
            20                  25                  30          


Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn Ser His Asn Ser Asn 
        35                  40                  45              


Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp Ile Ile Val Val Ala 
    50                  55                  60                  


Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu Ser Phe Gln Lys 
65                  70                  75                  80  


Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu Trp Trp Lys Ala 
                85                  90                  95      


Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro Ser Asn Tyr Val 
            100                 105                 110         


Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly Ile 
        115                 120                 125             


Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Met Leu 
    130                 135                 140                 


Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr Ser 
145                 150                 155                 160 


Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp Thr Val Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His Tyr Lys Lys Gly 
        195                 200                 205             


Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Met Ser Ser Lys 
    210                 215                 220                 


Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser 
225                 230                 235                 240 


Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met Lys 
            260                 265                 270         


Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Val Met 
        275                 280                 285             


Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly Ser Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln Pro Leu Pro Lys 
                325                 330                 335     


Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu 
            340                 345                 350         


Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Val 
    370                 375                 380                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile 
385                 390                 395                 400 


Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile Lys 
                405                 410                 415     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr Tyr 
            420                 425                 430         


Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Ala 
        435                 440                 445             


Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn Cys Pro Glu Glu 
    450                 455                 460                 


Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
            500                 505 


<210>  257
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val Gly Gly Asn Thr Phe 
1               5                   10                  15      


Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys Pro Val Tyr Val Pro 
            20                  25                  30          


Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn Ser His Asn Ser Asn 
        35                  40                  45              


Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp Ile Ile Val Val Ala 
    50                  55                  60                  


Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu Ser Phe Gln Lys 
65                  70                  75                  80  


Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu Trp Trp Lys Ala 
                85                  90                  95      


Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro Ser Asn Tyr Val 
            100                 105                 110         


Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly Ile 
        115                 120                 125             


Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Met Leu 
    130                 135                 140                 


Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr Ser 
145                 150                 155                 160 


Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp Thr Val Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His Tyr Lys Lys Gly 
        195                 200                 205             


Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Met Ser Ser Lys 
    210                 215                 220                 


Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser 
225                 230                 235                 240 


Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met Lys 
            260                 265                 270         


Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Val Met 
        275                 280                 285             


Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly Ser Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln Pro Leu Pro Lys 
                325                 330                 335     


Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu 
            340                 345                 350         


Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Val 
    370                 375                 380                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile 
385                 390                 395                 400 


Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile Lys 
                405                 410                 415     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr Tyr 
            420                 425                 430         


Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Ala 
        435                 440                 445             


Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn Cys Pro Glu Glu 
    450                 455                 460                 


Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
            500                 505 


<210>  258
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Gly Ser Glu Asp Ile 
65                  70                  75                  80  


Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu 
                85                  90                  95      


Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu 
            100                 105                 110         


Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro 
        115                 120                 125             


Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe 
    130                 135                 140                 


Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
145                 150                 155                 160 


Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys 
                165                 170                 175     


Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp 
            180                 185                 190         


Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr 
        195                 200                 205             


Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His 
    210                 215                 220                 


Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys 
225                 230                 235                 240 


Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile 
                245                 250                 255     


Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe 
            260                 265                 270         


Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val 
        275                 280                 285             


Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu 
    290                 295                 300                 


Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His 
305                 310                 315                 320 


Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala 
                325                 330                 335     


Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln 
            340                 345                 350         


Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met 
        355                 360                 365             


Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
    370                 375                 380                 


Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly 
385                 390                 395                 400 


Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
                405                 410                 415     


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser 
            420                 425                 430         


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu 
        435                 440                 445             


Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu 
    450                 455                 460                 


Val Ile 
465     


<210>  259
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val Gly Gly Asn Thr Phe 
1               5                   10                  15      


Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys Pro Val Tyr Val Pro 
            20                  25                  30          


Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn Ser His Asn Ser Asn 
        35                  40                  45              


Thr Pro Gly Ile Arg Glu Gly Ser Glu Asp Ile Ile Val Val Ala Leu 
    50                  55                  60                  


Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu Ser Phe Gln Lys Gly 
65                  70                  75                  80  


Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu Trp Trp Lys Ala Arg 
                85                  90                  95      


Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro Ser Asn Tyr Val Ala 
            100                 105                 110         


Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly Ile Ser 
        115                 120                 125             


Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Met Leu Gly 
    130                 135                 140                 


Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr Ser Leu 
145                 150                 155                 160 


Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp Thr Val Lys His Tyr 
                165                 170                 175     


Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg Ser 
            180                 185                 190         


Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His Tyr Lys Lys Gly Asn 
        195                 200                 205             


Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Met Ser Ser Lys Pro 
    210                 215                 220                 


Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu 
225                 230                 235                 240 


Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val Trp Met 
                245                 250                 255     


Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met Lys Pro 
            260                 265                 270         


Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Val Met Lys 
        275                 280                 285             


Thr Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val Thr Lys 
    290                 295                 300                 


Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly Ser Leu Leu 
305                 310                 315                 320 


Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln Pro Leu Pro Lys Leu 
                325                 330                 335     


Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu Gln 
            340                 345                 350         


Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser 
        355                 360                 365             


Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Val Ile 
    370                 375                 380                 


Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile Lys Ser 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr Tyr Gly 
            420                 425                 430         


Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Ala Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn Cys Pro Glu Glu Leu 
    450                 455                 460                 


Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg Pro Glu Glu Arg Pro 
465                 470                 475                 480 


Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala Thr 
                485                 490                 495     


Glu Ser Gln Tyr Gln Gln Gln Pro 
            500                 


<210>  260
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val Gly Gly Asn Thr 
1               5                   10                  15      


Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys Pro Val Tyr Val 
            20                  25                  30          


Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn Ser His Asn Ser 
        35                  40                  45              


Asn Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp Ile Ile Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu Ser Phe Gln 
65                  70                  75                  80  


Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu Trp Trp Lys 
                85                  90                  95      


Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro Ser Asn Tyr 
            100                 105                 110         


Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly 
        115                 120                 125             


Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Met 
    130                 135                 140                 


Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr 
145                 150                 155                 160 


Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp Thr Val Lys 
                165                 170                 175     


His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro 
            180                 185                 190         


Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His Tyr Lys Lys 
        195                 200                 205             


Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Met Ser Ser 
    210                 215                 220                 


Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu 
225                 230                 235                 240 


Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val 
                245                 250                 255     


Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met 
            260                 265                 270         


Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Val 
        275                 280                 285             


Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val 
    290                 295                 300                 


Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly Ser 
305                 310                 315                 320 


Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln Pro Leu Pro 
                325                 330                 335     


Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Phe Ile 
            340                 345                 350         


Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu 
        355                 360                 365             


Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg 
    370                 375                 380                 


Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro 
385                 390                 395                 400 


Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile 
                405                 410                 415     


Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr 
            420                 425                 430         


Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg 
        435                 440                 445             


Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn Cys Pro Glu 
    450                 455                 460                 


Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg Pro Glu Glu 
465                 470                 475                 480 


Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr 
                485                 490                 495     


Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
            500                 505     


<210>  261
<211>  1507
<212>  DNA
<213>  Mus musculus

<400>  261
atgcgtgaag tccaggttcc tccgagatgg aagcaaggcc tcaaaaacag agccaagtgc       60

caatcagaag ggccctgtgt atgtgccgga tcccacgtcc tccagcaagc tgggaccaaa      120

caacagcaac agcatgcccc cagggtttgt ggagggctct gaggatacca ttgtggtcgc      180

actgtacgac tatgaggcta ttcaccgtga agacctcagc ttccagaagg gagaccagat      240

ggtggttctg gaggaggctg gggagtggtg gaaggcacgg tccctggcta ccaagaagga      300

aggctacatc ccaagcaact atgtggctcg agttaactct ttggagacag aagagtggtt      360

cttcaagggg atcagccgga aggatgcaga gcgccacctc ctggctccag gcaacatgct      420

gggctccttc atgatccggg acagtgagac caccaaaggg agctactcgt tgtctgttcg      480

agactttgac ccccagcacg gagacaccgt gaagcactat aagatccgga cgctggacag      540

tggaggcttc tacatctctc caaggagcac cttcagcagc ctgcaggaac tcgtgctcca      600

ctacaagaag gggaaggatg ggctctgcca gaagctgtca gtgccctgtg tgtctcccaa      660

accccagaag ccatgggaga aagatgcttg ggagattcct cgagaatccc tccagatgga      720

gaagaaactt ggagctgggc agtttggaga agtgtggatg gccacctaca acaagcacac      780

caaagtggcg gtgaagacaa tgaagccagg gagcatgtcc gtggaggcct tcctggctga      840

ggccaacctg atgaagtcgc tgcagcatga caaactggtg aagctacacg ctgtggtctc      900

tcaggagccc atctttattg tcacggagtt catggccaaa ggaagcctgc tggactttct      960

caagagtgaa gaaggcagca agcagccact gccaaaactc attgacttct cagcccagat     1020

ctcagaaggc atggccttca ttgagcagag gaactacatc caccgagacc tgagggctgc     1080

caacatctta gtctctgcat cactggtgtg taagattgct gactttggac tggcacgaat     1140

catcgaggac aatgagtaca cagctcggga aggagccaag ttccccatca agtggacagc     1200

tcctgaagcc atcaactttg gttccttcac catcaagtca gatgtctggt cctttggtat     1260

cctgctgatg gaaattgtca cctatggccg gatcccttac ccaggtatgt caaacccaga     1320

ggtgattcgg gcactagagc atgggtaccg tatgcctcga ccagataact gtccagaaga     1380

gctctacaat atcatgatcc gctgctggaa gaaccgcccc gaggaacggc ccacctttga     1440

atacatccag agtgtgctgg atgacttcta cacggccact gagagccagt atcagcagca     1500

gccttga                                                               1507


<210>  262
<211>  1512
<212>  DNA
<213>  Mus musculus

<400>  262
atgggatgcg tgaagtccag gttcctccga gatggaagca aggcctcaaa aacagagcca       60

agtgccaatc agaagggccc tgtgtatgtg ccggatccca cgtcctccag caagctggga      120

ccaaacaaca gcaacagcat gcccccaggg tttgtggagg gctctgagga taccattgtg      180

gtcgcactgt acgactatga ggctattcac cgtgaagacc tcagcttcca gaagggagac      240

cagatggtgg ttctggagga ggctggggag tggtggaagg cacggtccct ggctaccaag      300

aaggaaggct acatcccaag caactatgtg gctcgagtta actctttgga gacagaagag      360

tggttcttca aggggatcag ccggaaggat gcagagcgcc acctcctggc tccaggcaac      420

atgctgggct ccttcatgat ccgggacagt gagaccacca aagggagcta ctcgttgtct      480

gttcgagact ttgaccccca gcacggagac accgtgaagc actataagat ccggacgctg      540

gacagtggag gcttctacat ctctccaagg agcaccttca gcagcctgca ggaactcgtg      600

ctccactaca agaaggggaa ggatgggctc tgccagaagc tgtcagtgcc ctgtgtgtct      660

cccaaacccc agaagccatg ggagaaagat gcttgggaga ttcctcgaga atccctccag      720

atggagaaga aacttggagc tgggcagttt ggagaagtgt ggatggccac ctacaacaag      780

cacaccaaag tggcggtgaa gacaatgaag ccagggagca tgtccgtgga ggccttcctg      840

gctgaggcca acctgatgaa gtcgctgcag catgacaaac tggtgaagct acacgctgtg      900

gtctctcagg agcccatctt tattgtcacg gagttcatgg ccaaaggaag cctgctggac      960

tttctcaaga gtgaagaagg cagcaagcag ccactgccaa aactcattga cttctcagcc     1020

cagatctcag aaggcatggc cttcattgag cagaggaact acatccaccg agacctgagg     1080

gctgccaaca tcttagtctc tgcatcactg gtgtgtaaga ttgctgactt tggactggca     1140

cgaatcatcg aggacaatga gtacacagct cgggaaggag ccaagttccc catcaagtgg     1200

acagctcctg aagccatcaa ctttggttcc ttcaccatca agtcagatgt ctggtccttt     1260

ggtatcctgc tgatggaaat tgtcacctat ggccggatcc cttacccagg tatgtcaaac     1320

ccagaggtga ttcgggcact agagcatggg taccgtatgc ctcgaccaga taactgtcca     1380

gaagagctct acaatatcat gatccgctgc tggaagaacc gccccgagga acggcccacc     1440

tttgaataca tccagagtgt gctggatgac ttctacacgg ccactgagag ccagtatcag     1500

cagcagcctt ga                                                         1512


<210>  263
<211>  524
<212>  PRT
<213>  Mus musculus

<400>  263

Met Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Ser Glu 
1               5                   10                  15      


Gly Arg Ala Pro Arg Met Gly Cys Val Lys Ser Arg Phe Leu Arg Asp 
            20                  25                  30          


Gly Ser Lys Ala Ser Lys Thr Glu Pro Ser Ala Asn Gln Lys Gly Pro 
        35                  40                  45              


Val Tyr Val Pro Asp Pro Thr Ser Ser Ser Lys Leu Gly Pro Asn Asn 
    50                  55                  60                  


Ser Asn Ser Met Pro Pro Gly Phe Val Glu Gly Ser Glu Asp Thr Ile 
65                  70                  75                  80  


Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His Arg Glu Asp Leu Ser 
                85                  90                  95      


Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ala Gly Glu Trp 
            100                 105                 110         


Trp Lys Ala Arg Ser Leu Ala Thr Lys Lys Glu Gly Tyr Ile Pro Ser 
        115                 120                 125             


Asn Tyr Val Ala Arg Val Asn Ser Leu Glu Thr Glu Glu Trp Phe Phe 
    130                 135                 140                 


Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg His Leu Leu Ala Pro Gly 
145                 150                 155                 160 


Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly 
                165                 170                 175     


Ser Tyr Ser Leu Ser Val Arg Asp Phe Asp Pro Gln His Gly Asp Thr 
            180                 185                 190         


Val Lys His Tyr Lys Ile Arg Thr Leu Asp Ser Gly Gly Phe Tyr Ile 
        195                 200                 205             


Ser Pro Arg Ser Thr Phe Ser Ser Leu Gln Glu Leu Val Leu His Tyr 
    210                 215                 220                 


Lys Lys Gly Lys Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Val 
225                 230                 235                 240 


Ser Pro Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro 
                245                 250                 255     


Arg Glu Ser Leu Gln Met Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly 
            260                 265                 270         


Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys 
        275                 280                 285             


Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala 
    290                 295                 300                 


Asn Leu Met Lys Ser Leu Gln His Asp Lys Leu Val Lys Leu His Ala 
305                 310                 315                 320 


Val Val Ser Gln Glu Pro Ile Phe Ile Val Thr Glu Phe Met Ala Lys 
                325                 330                 335     


Gly Ser Leu Leu Asp Phe Leu Lys Ser Glu Glu Gly Ser Lys Gln Pro 
            340                 345                 350         


Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ser Glu Gly Met Ala 
        355                 360                 365             


Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn 
    370                 375                 380                 


Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu 
385                 390                 395                 400 


Ala Arg Ile Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys 
                405                 410                 415     


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe 
            420                 425                 430         


Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile 
        435                 440                 445             


Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val 
    450                 455                 460                 


Ile Arg Ala Leu Glu His Gly Tyr Arg Met Pro Arg Pro Asp Asn Cys 
465                 470                 475                 480 


Pro Glu Glu Leu Tyr Asn Ile Met Ile Arg Cys Trp Lys Asn Arg Pro 
                485                 490                 495     


Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe 
            500                 505                 510         


Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 


<210>  264
<211>  503
<212>  PRT
<213>  Mus musculus

<400>  264

Met Gly Cys Val Lys Ser Arg Phe Leu Arg Asp Gly Ser Lys Ala Ser 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ala Asn Gln Lys Gly Pro Val Tyr Val Pro Asp 
            20                  25                  30          


Pro Thr Ser Ser Ser Lys Leu Gly Pro Asn Asn Ser Asn Ser Met Pro 
        35                  40                  45              


Pro Gly Phe Val Glu Gly Ser Glu Asp Thr Ile Val Val Ala Leu Tyr 
    50                  55                  60                  


Asp Tyr Glu Ala Ile His Arg Glu Asp Leu Ser Phe Gln Lys Gly Asp 
65                  70                  75                  80  


Gln Met Val Val Leu Glu Glu Ala Gly Glu Trp Trp Lys Ala Arg Ser 
                85                  90                  95      


Leu Ala Thr Lys Lys Glu Gly Tyr Ile Pro Ser Asn Tyr Val Ala Arg 
            100                 105                 110         


Val Asn Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly Ile Ser Arg 
        115                 120                 125             


Lys Asp Ala Glu Arg His Leu Leu Ala Pro Gly Asn Met Leu Gly Ser 
    130                 135                 140                 


Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr Ser Leu Ser 
145                 150                 155                 160 


Val Arg Asp Phe Asp Pro Gln His Gly Asp Thr Val Lys His Tyr Lys 
                165                 170                 175     


Ile Arg Thr Leu Asp Ser Gly Gly Phe Tyr Ile Ser Pro Arg Ser Thr 
            180                 185                 190         


Phe Ser Ser Leu Gln Glu Leu Val Leu His Tyr Lys Lys Gly Lys Asp 
        195                 200                 205             


Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Val Ser Pro Lys Pro Gln 
    210                 215                 220                 


Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Gln 
225                 230                 235                 240 


Met Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val Trp Met Ala 
                245                 250                 255     


Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met Lys Pro Gly 
            260                 265                 270         


Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Leu Met Lys Ser 
        275                 280                 285             


Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val Ser Gln Glu 
    290                 295                 300                 


Pro Ile Phe Ile Val Thr Glu Phe Met Ala Lys Gly Ser Leu Leu Asp 
305                 310                 315                 320 


Phe Leu Lys Ser Glu Glu Gly Ser Lys Gln Pro Leu Pro Lys Leu Ile 
                325                 330                 335     


Asp Phe Ser Ala Gln Ile Ser Glu Gly Met Ala Phe Ile Glu Gln Arg 
            340                 345                 350         


Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser Ala 
        355                 360                 365             


Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile Ile Glu 
    370                 375                 380                 


Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys Trp 
385                 390                 395                 400 


Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile Lys Ser Asp 
                405                 410                 415     


Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr Tyr Gly Arg 
            420                 425                 430         


Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Ala Leu Glu 
        435                 440                 445             


His Gly Tyr Arg Met Pro Arg Pro Asp Asn Cys Pro Glu Glu Leu Tyr 
    450                 455                 460                 


Asn Ile Met Ile Arg Cys Trp Lys Asn Arg Pro Glu Glu Arg Pro Thr 
465                 470                 475                 480 


Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala Thr Glu 
                485                 490                 495     


Ser Gln Tyr Gln Gln Gln Pro 
            500             


<210>  265
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  265
atgggtagca acaagagcaa gcccaaggat gccagccagc ggcgccgcag cctggagccc       60

gccgagaacg tgcacggcgc tggcgggggc gctttccccg cctcgcagac ccccagcaag      120

ccagcctcgg ccgacggcca ccgcggcccc agcgcggcct tcgcccccgc ggccgccgag      180

cccaagctgt tcggaggctt caactcctcg gacaccgtca cctccccgca gagggcgggc      240

ccgctggccg gtggagtgac cacctttgtg gccctctatg actatgagtc taggacggag      300

acagacctgt ccttcaagaa aggcgagcgg ctccagattg tcaacaacac agagggagac      360

tggtggctgg cccactcgct cagcacagga cagacaggct acatccccag caactacgtg      420

gcgccctccg actccatcca ggctgaggag tggtattttg gcaagatcac cagacgggag      480

tcagagcggt tactgctcaa tgcagagaac ccgagaggga ccttcctcgt gcgagaaagt      540

gagaccacga aaggtgccta ctgcctctca gtgtctgact tcgacaacgc caagggcctc      600

aacgtgaagc actacaagat ccgcaagctg gacagcggcg gcttctacat cacctcccgc      660

acccagttca acagcctgca gcagctggtg gcctactact ccaaacacgc cgatggcctg      720

tgccaccgcc tcaccaccgt gtgccccacg tccaagccgc agactcaggg cctggccaag      780

gatgcctggg agatccctcg ggagtcgctg cggctggagg tcaagctggg ccagggctgc      840

tttggcgagg tgtggatggg gacctggaac ggtaccacca gggtggccat caaaaccctg      900

aagcctggca cgatgtctcc agaggccttc ctgcaggagg cccaggtcat gaagaagctg      960

aggcatgaga agctggtgca gttgtatgct gtggtttcag aggagcccat ttacatcgtc     1020

acggagtaca tgagcaaggg gagtttgctg gactttctca agggggagac aggcaagtac     1080

ctgcggctgc ctcagctggt ggacatggct gctcagatcg cctcaggcat ggcgtacgtg     1140

gagcggatga actacgtcca ccgggacctt cgtgcagcca acatcctggt gggagagaac     1200

ctggtgtgca aagtggccga ctttgggctg gctcggctca ttgaagacaa tgagtacacg     1260

gcgcggcaag gtgccaaatt ccccatcaag tggacggctc cagaagctgc cctctatggc     1320

cgcttcacca tcaagtcgga cgtgtggtcc ttcgggatcc tgctgactga gctcaccaca     1380

aagggacggg tgccctaccc tgggatggtg aaccgcgagg tgctggacca ggtggagcgg     1440

ggctaccgga tgccctgccc gccggagtgt cccgagtccc tgcacgacct catgtgccag     1500

tgctggcgga aggagcctga ggagcggccc accttcgagt acctgcaggc cttcctggag     1560

gactacttca cgtccaccga gccccagtac cagcccgggg agaacctcta g              1611


<210>  266
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  266
atgggtagca acaagagcaa gcccaaggat gccagccagc ggcgccgcag cctggagccc       60

gccgagaacg tgcacggcgc tggcgggggc gctttccccg cctcgcagac ccccagcaag      120

ccagcctcgg ccgacggcca ccgcggcccc agcgcggcct tcgcccccgc ggccgccgag      180

cccaagctgt tcggaggctt caactcctcg gacaccgtca cctccccgca gagggcgggc      240

ccgctggccg gtggagtgac cacctttgtg gccctctatg actatgagtc taggacggag      300

acagacctgt ccttcaagaa aggcgagcgg ctccagattg tcaacaacac agagggagac      360

tggtggctgg cccactcgct cagcacagga cagacaggct acatccccag caactacgtg      420

gcgccctccg actccatcca ggctgaggag tggtattttg gcaagatcac cagacgggag      480

tcagagcggt tactgctcaa tgcagagaac ccgagaggga ccttcctcgt gcgagaaagt      540

gagaccacga aaggtgccta ctgcctctca gtgtctgact tcgacaacgc caagggcctc      600

aacgtgaagc actacaagat ccgcaagctg gacagcggcg gcttctacat cacctcccgc      660

acccagttca acagcctgca gcagctggtg gcctactact ccaaacacgc cgatggcctg      720

tgccaccgcc tcaccaccgt gtgccccacg tccaagccgc agactcaggg cctggccaag      780

gatgcctggg agatccctcg ggagtcgctg cggctggagg tcaagctggg ccagggctgc      840

tttggcgagg tgtggatggg gacctggaac ggtaccacca gggtggccat caaaaccctg      900

aagcctggca cgatgtctcc agaggccttc ctgcaggagg cccaggtcat gaagaagctg      960

aggcatgaga agctggtgca gttgtatgct gtggtttcag aggagcccat ttacatcgtc     1020

acggagtaca tgagcaaggg gagtttgctg gactttctca agggggagac aggcaagtac     1080

ctgcggctgc ctcagctggt ggacatggct gctcagatcg cctcaggcat ggcgtacgtg     1140

gagcggatga actacgtcca ccgggacctt cgtgcagcca acatcctggt gggagagaac     1200

ctggtgtgca aagtggccga ctttgggctg gctcggctca ttgaagacaa tgagtacacg     1260

gcgcggcaag gtgccaaatt ccccatcaag tggacggctc cagaagctgc cctctatggc     1320

cgcttcacca tcaagtcgga cgtgtggtcc ttcgggatcc tgctgactga gctcaccaca     1380

aagggacggg tgccctaccc tgggatggtg aaccgcgagg tgctggacca ggtggagcgg     1440

ggctaccgga tgccctgccc gccggagtgt cccgagtccc tgcacgacct catgtgccag     1500

tgctggcgga aggagcctga ggagcggccc accttcgagt acctgcaggc cttcctggag     1560

gactacttca cgtccaccga gccccagtac cagcccgggg agaacctcta g              1611


<210>  267
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  268
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  269
<211>  1626
<212>  DNA
<213>  Mus musculus

<400>  269
atgggcagca acaagagcaa gcccaaggac gccagccagc ggcgccgcag cctggagccc       60

tcggaaaacg tgcacggggc agggggcgcc ttcccggcct cacagacacc gagcaagccc      120

gcctccgccg acggccaccg cgggcccagc gccgccttcg tgccgcccgc ggccgagccc      180

aagctcttcg gaggcttcaa ctcctcggac accgtcacct ccccgcagag ggcggggcct      240

ctggcaggtg gggtgaccac ctttgtggcc ctctatgact atgagtcacg gacagagact      300

gacctgtcct tcaagaaagg ggagcggctg cagattgtca ataacacgag gaaggtggat      360

gtcagagagg gagactggtg gctggcacac tcgctgagca cgggacagac cggttacatc      420

cccagcaact atgtggcgcc ctccgactcc atccaggctg aggagtggta ctttggcaag      480

atcactagac gggaatcaga gcggctgctg ctcaacgccg agaacccgag agggaccttc      540

ctcgtgaggg agagtgagac cacaaaaggt gcctactgcc tctctgtatc cgacttcgac      600

aatgccaagg gcctaaatgt gaaacactac aagatccgca agctggacag cggcggtttc      660

tacatcacct cccgcaccca gttcaacagc ctgcagcagc tcgtggctta ctactccaaa      720

catgctgatg gcctgtgtca ccgcctcact accgtatgtc ccacatccaa gcctcagacc      780

cagggattgg ccaaggatgc gtgggagatc ccccgggagt ccctgcggct ggaggtcaag      840

ctgggccagg gttgcttcgg agaggtgtgg atggggacct ggaacggcac cacgagggtt      900

gccatcaaaa ctctgaagcc aggcaccatg tccccagagg ccttcctgca ggaggcccaa      960

gtcatgaaga aactgaggca cgagaaactg gtgcagctgt atgctgtggt gtcggaagaa     1020

cccatttaca ttgtgacaga gtacatgaac aaggggagtc tgctggactt tctcaagggg     1080

gaaacgggca aatatttgcg gctaccccag ctggtggaca tgtctgctca gatcgcttca     1140

ggcatggcct atgtggagcg gatgaactat gtgcaccggg accttcgagc cgccaatatc     1200

ctagtagggg agaacctggt gtgcaaagtg gccgactttg ggttggcccg gctcatagaa     1260

gacaacgaat acacagcccg gcaaggtgcc aaattcccca tcaagtggac cgcccctgaa     1320

gctgctctgt acggcaggtt caccatcaag tcggatgtgt ggtcctttgg gattctgctg     1380

accgagctca ccactaaggg aagagtgccc tatcctggga tggtgaaccg tgaggttctg     1440

gaccaggtgg agcggggcta ccggatgcct tgtccccccg agtgccccga gtccctgcat     1500

gaccttatgt gccagtgctg gcggaaggag cccgaggagc ggcccacctt cgagtacctg     1560

caggccttcc tggaagacta ctttacgtcc actgagccac agtaccagcc cggggagaac     1620

ctatag                                                                1626


<210>  270
<211>  1608
<212>  DNA
<213>  Mus musculus

<400>  270
atgggcagca acaagagcaa gcccaaggac gccagccagc ggcgccgcag cctggagccc       60

tcggaaaacg tgcacggggc agggggcgcc ttcccggcct cacagacacc gagcaagccc      120

gcctccgccg acggccaccg cgggcccagc gccgccttcg tgccgcccgc ggccgagccc      180

aagctcttcg gaggcttcaa ctcctcggac accgtcacct ccccgcagag ggcggggcct      240

ctggcaggtg gggtgaccac ctttgtggcc ctctatgact atgagtcacg gacagagact      300

gacctgtcct tcaagaaagg ggagcggctg cagattgtca ataacacaga gggagactgg      360

tggctggcac actcgctgag cacgggacag accggttaca tccccagcaa ctatgtggcg      420

ccctccgact ccatccaggc tgaggagtgg tactttggca agatcactag acgggaatca      480

gagcggctgc tgctcaacgc cgagaacccg agagggacct tcctcgtgag ggagagtgag      540

accacaaaag gtgcctactg cctctctgta tccgacttcg acaatgccaa gggcctaaat      600

gtgaaacact acaagatccg caagctggac agcggcggtt tctacatcac ctcccgcacc      660

cagttcaaca gcctgcagca gctcgtggct tactactcca aacatgctga tggcctgtgt      720

caccgcctca ctaccgtatg tcccacatcc aagcctcaga cccagggatt ggccaaggat      780

gcgtgggaga tcccccggga gtccctgcgg ctggaggtca agctgggcca gggttgcttc      840

ggagaggtgt ggatggggac ctggaacggc accacgaggg ttgccatcaa aactctgaag      900

ccaggcacca tgtccccaga ggccttcctg caggaggccc aagtcatgaa gaaactgagg      960

cacgagaaac tggtgcagct gtatgctgtg gtgtcggaag aacccattta cattgtgaca     1020

gagtacatga acaaggggag tctgctggac tttctcaagg gggaaacggg caaatatttg     1080

cggctacccc agctggtgga catgtctgct cagatcgctt caggcatggc ctatgtggag     1140

cggatgaact atgtgcaccg ggaccttcga gccgccaata tcctagtagg ggagaacctg     1200

gtgtgcaaag tggccgactt tgggttggcc cggctcatag aagacaacga atacacagcc     1260

cggcaaggtg ccaaattccc catcaagtgg accgcccctg aagctgctct gtacggcagg     1320

ttcaccatca agtcggatgt gtggtccttt gggattctgc tgaccgagct caccactaag     1380

ggaagagtgc cctatcctgg gatggtgaac cgtgaggttc tggaccaggt ggagcggggc     1440

taccggatgc cttgtccccc cgagtgcccc gagtccctgc atgaccttat gtgccagtgc     1500

tggcggaagg agcccgagga gcggcccacc ttcgagtacc tgcaggcctt cctggaagac     1560

tactttacgt ccactgagcc acagtaccag cccggggaga acctatag                  1608


<210>  271
<211>  541
<212>  PRT
<213>  Mus musculus

<400>  271

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ser Glu Asn Val His Gly Ala Gly Gly Ala Phe Pro 
            20                  25                  30          


Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg Gly 
        35                  40                  45              


Pro Ser Ala Ala Phe Val Pro Pro Ala Ala Glu Pro Lys Leu Phe Gly 
    50                  55                  60                  


Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly Pro 
65                  70                  75                  80  


Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu Ser 
                85                  90                  95      


Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln Ile 
            100                 105                 110         


Val Asn Asn Thr Arg Lys Val Asp Val Arg Glu Gly Asp Trp Trp Leu 
        115                 120                 125             


Ala His Ser Leu Ser Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr 
    130                 135                 140                 


Val Ala Pro Ser Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys 
145                 150                 155                 160 


Ile Thr Arg Arg Glu Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro 
                165                 170                 175     


Arg Gly Thr Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr 
            180                 185                 190         


Cys Leu Ser Val Ser Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys 
        195                 200                 205             


His Tyr Lys Ile Arg Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser 
    210                 215                 220                 


Arg Thr Gln Phe Asn Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys 
225                 230                 235                 240 


His Ala Asp Gly Leu Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser 
                245                 250                 255     


Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg 
            260                 265                 270         


Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu 
        275                 280                 285             


Val Trp Met Gly Thr Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr 
    290                 295                 300                 


Leu Lys Pro Gly Thr Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln 
305                 310                 315                 320 


Val Met Lys Lys Leu Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val 
                325                 330                 335     


Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly 
            340                 345                 350         


Ser Leu Leu Asp Phe Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu 
        355                 360                 365             


Pro Gln Leu Val Asp Met Ser Ala Gln Ile Ala Ser Gly Met Ala Tyr 
    370                 375                 380                 


Val Glu Arg Met Asn Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile 
385                 390                 395                 400 


Leu Val Gly Glu Asn Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala 
                405                 410                 415     


Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr 
    450                 455                 460                 


Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu 
465                 470                 475                 480 


Asp Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro 
                485                 490                 495     


Glu Ser Leu His Asp Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu 
            500                 505                 510         


Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe 
        515                 520                 525             


Thr Ser Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540     


<210>  272
<211>  535
<212>  PRT
<213>  Mus musculus

<400>  272

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ser Glu Asn Val His Gly Ala Gly Gly Ala Phe Pro 
            20                  25                  30          


Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg Gly 
        35                  40                  45              


Pro Ser Ala Ala Phe Val Pro Pro Ala Ala Glu Pro Lys Leu Phe Gly 
    50                  55                  60                  


Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly Pro 
65                  70                  75                  80  


Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu Ser 
                85                  90                  95      


Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln Ile 
            100                 105                 110         


Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser Thr 
        115                 120                 125             


Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp Ser 
    130                 135                 140                 


Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu Ser 
145                 150                 155                 160 


Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu Val 
                165                 170                 175     


Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser Asp 
            180                 185                 190         


Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg Lys 
        195                 200                 205             


Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn Ser 
    210                 215                 220                 


Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu Cys 
225                 230                 235                 240 


His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln Gly 
                245                 250                 255     


Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu Glu 
            260                 265                 270         


Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr Trp 
        275                 280                 285             


Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met 
    290                 295                 300                 


Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu Arg 
305                 310                 315                 320 


His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile 
                325                 330                 335     


Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu 
            340                 345                 350         


Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp Met 
        355                 360                 365             


Ser Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn Tyr 
    370                 375                 380                 


Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn Leu 
385                 390                 395                 400 


Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn 
                405                 410                 415     


Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala 
            420                 425                 430         


Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp 
        435                 440                 445             


Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val Pro 
    450                 455                 460                 


Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg Gly 
465                 470                 475                 480 


Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp Leu 
                485                 490                 495     


Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe Glu 
            500                 505                 510         


Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro Gln 
        515                 520                 525             


Tyr Gln Pro Gly Glu Asn Leu 
    530                 535 


<210>  273
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  273
caccgtacaa agccaaaaac aagg                                              24


<210>  274
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  274
aaacccttgt ttttggcttt gtac                                              24


<210>  275
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  275
caccggagcg gcttctgtac ccgc                                              24


<210>  276
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  276
aaacgcgggt acagaagccg ctcc                                              24


<210>  277
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  277
caccggcaac tgcggcatag caacc                                             25


<210>  278
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  278
aaacggttgc tatgccgcag ttgcc                                             25


<210>  279
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  279
caccggtgac ctgcccggtt ctcag                                             25


<210>  280
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  280
aaacctgaga accgggcagg tcacc                                             25


<210>  281
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  281
caccgcgggg acacaggatc cctgg                                             25


<210>  282
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  282
aaacccaggg atcctgtgtc cccgc                                             25


<210>  283
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  283
caccggttag ggcatgccag aacag                                             25


<210>  284
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  284
aaacctgttc tggcatgccc taacc                                             25


<210>  285
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  285
caccgatggt gtgctcaaaa tcaga                                             25


<210>  286
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  286
aaactctgat tttgagcaca ccatc                                             25


<210>  287
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  287
caccgggaca tccagcacag cctg                                              24


<210>  288
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  288
aaaccaggct gtgctggatg tccc                                              24


<210>  289
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  289
caccgtggtg gtggccttca aatca                                             25


<210>  290
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  290
aaactgattt gaaggccacc accac                                             25


<210>  291
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  291
caccgcaggg agcagcccac ggtag                                             25


<210>  292
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  292
aaacctaccg tgggctgctc cctgc                                             25


<210>  293
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  293
caccgagcgc caccagagac cagac                                             25


<210>  294
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  294
aaacgtctgg tctctggtgg cgctc                                             25


<210>  295
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  295
caccgctaga atccagtctg gtctc                                             25


<210>  296
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  296
aaacgagacc agactggatt ctagc                                             25


<210>  297
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  297
caccgagtaa tcacccagag tgcaa                                             25


<210>  298
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  298
aaacttgcac tctgggtgat tactc                                             25


<210>  299
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  299
caccgagagg acttggagtc gctga                                             25


<210>  300
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  300
aaactcagcg actccaagtc ctctc                                             25


<210>  301
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  301
ccttgaagga agatgatcaa atgagagc                                          28


<210>  302
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  302
ccagcctggg gccagttctt atc                                               23


<210>  303
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  303
agtcagctag catgtcagca atacaggccg cctg                                   34


<210>  304
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  304
agtcaggatc ctcaagcgta atctggaaca tcgtatgggt acaggtgcag ctcgtgggtt       60

ttg                                                                     63


<210>  305
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  305
agtcagctag catgtctgat aacggagaac tggaagataa gcc                         43


<210>  306
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  306
agtcaggatc cttacttgtc gtcatcgtct ttgtagtcac ggttactctt cattgcttct       60

ttagctgcc                                                               69


<210>  307
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  307
gttggccgtg agggcatcat c                                                 21


<210>  308
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  308
cttgtttttg gctttgtacc agttgg                                            26


<210>  309
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  309
cgcctgagac aggcctgttc ctg                                               23


<210>  310
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  310
ggtacagaag ccgctcagcc tgctc                                             25


<210>  311
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  311
cttgtgcagc tcctgggcgt ga                                                22


<210>  312
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  312
gttgctatgc cgcagttgcg tca                                               23


<210>  313
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  313
aagttcttcg actccaacac agtgaagcag a                                      31


<210>  314
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  314
taggacatcc agcacagcct gagg                                              24


<210>  315
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  315
cagaaatttc tgagctttac tcctcctgag aaagatg                                37


<210>  316
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  316
cttcactgtg ttggagtcgt agaactttag gac                                    33


<210>  317
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  317
tcaattttca cacggtctgt aattgaccct g                                      31


<210>  318
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  318
tttcgtatga tccggtcgcg g                                                 21


<210>  319
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  319
aatggactat catatgctta ccgtaacttg aaagtatttc g                           41


<210>  320
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  320
tctactattc tttcccctgc actgtacctg tgggcgatgt gcgctctg                    48


<210>  321
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  321
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatcttc       60

ttgtggaaag gacgaaacac cg                                                82


<210>  322
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"


<220>
<221>  misc_feature
<222>  (59)..(64)
<223>  n is a, c, g, or t

<400>  322
caagcagaag acggcatacg agatgtgact ggagttcaga cgtgtgctct tccgatctnn       60

nnnntctact attctttccc ctgcactgta cc                                     92


<210>  323
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  323
ctcttccgat cttcttgtgg aaaggacgaa acaccg                                 36


<210>  324
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  324
catcgcccac aggtacagtg caggggaaag aatagtaga                              39


<210>  325
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  325
ggtgtgaacc atgagaagta tga                                               23


<210>  326
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  326
gagtccttcc acgataccaa ag                                                22


<210>  327
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  327
cggaatcctt ctctgggaaa tc                                                22


<210>  328
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  328
catccatctt gtagcccttc tc                                                22


<210>  329
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Consensus binding 
       motif"


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  329

Leu Xaa Xaa Leu Leu 
1               5