                               SEQUENCE LISTING

<110> AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

<120> POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOF

<130> P000461WO1

<140>
<141>

<150> 10201605841S
<151> 2016-07-15

<160> 197

<170> PatentIn version 3.5

<210> 1
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      ELABELA polypeptide signature sequence


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<400> 1
Cys Xaa Xaa Xaa Arg Cys Xaa Xaa Xaa His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 2
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2
Gln Arg Pro Val Asn Leu Thr Met Arg Arg Lys Leu Arg Lys His Asn
1               5                   10                  15


Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 3
<211> 32
<212> PRT
<213> Peromyscus sp.

<400> 3
Gln Arg Pro Val Asn Phe Pro Lys Lys Arg Lys Val Tyr Arg His Asn
1               5                   10                  15


Cys Phe Arg Arg Arg Cys Val Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 4
<211> 32
<212> PRT
<213> Rattus sp.

<400> 4
Glu Lys Ser Val Asn Phe Pro Arg Arg Arg Lys Leu Tyr Arg His Asn
1               5                   10                  15


Cys Phe Arg Arg Arg Cys Ile Ser Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 5
<211> 32
<212> PRT
<213> Mus musculus

<400> 5
Gln Lys Pro Val Asn Phe Pro Arg Arg Arg Lys Leu Tyr Arg His Asn
1               5                   10                  15


Cys Phe Arg Arg Arg Cys Ile Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 6
<211> 32
<212> PRT
<213> Bos sp.

<400> 6
Gln Arg Gln Ala Asn Leu Ala Met Arg Arg Lys Leu His Arg His Asn
1               5                   10                  15


Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 7
<211> 32
<212> PRT
<213> Sus sp.

<400> 7
Gln Arg Pro Ala Asn Leu Ala Val Arg Arg Lys Leu His Arg His Asn
1               5                   10                  15


Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 8
<211> 32
<212> PRT
<213> Dasypus sp.

<400> 8
Gln Arg Pro Ala Asn Leu Ala Met Arg Arg Lys Leu His Arg His Asn
1               5                   10                  15


Cys Phe Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 9
<211> 32
<212> PRT
<213> Trichosurus sp.

<400> 9
Gln Arg Pro Gly Asn Leu Ala Leu Arg Arg Lys Pro His Arg His Ile
1               5                   10                  15


Cys Pro Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 10
<211> 32
<212> PRT
<213> Gallus gallus

<400> 10
Gln Arg Pro Ala Asn Leu Ala Leu Arg Arg Lys Leu His Arg His Asn
1               5                   10                  15


Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 11
<211> 32
<212> PRT
<213> Gekko sp.

<400> 11
Gln Arg Pro Ala Asn Leu Ser Leu Arg Arg Lys Leu His Arg Gln His
1               5                   10                  15


Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 12
<211> 32
<212> PRT
<213> Anolis sp.

<400> 12
Gln Arg Pro Ala Asn Leu Ala Ser Arg Arg Lys Leu His Arg His His
1               5                   10                  15


Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 13
<211> 32
<212> PRT
<213> Xenopus laevis

<400> 13
Gln Lys Pro Ala Asn Leu Ala Gln Arg Arg Arg Ile His Arg His Asn
1               5                   10                  15


Cys Phe Leu Lys Arg Cys Ile Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 14
<211> 32
<212> PRT
<213> Ambystoma sp.

<400> 14
Gln Arg Pro Val Asn Ala Ala His Arg Arg Arg Leu His Arg His Asn
1               5                   10                  15


Cys Ser Leu Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 15
<211> 32
<212> PRT
<213> Oryzias sp.

<400> 15
Ala Arg Pro Asp Phe Leu Asn Leu Arg Arg Lys Tyr His Arg His His
1               5                   10                  15


Cys Leu His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 16
<211> 32
<212> PRT
<213> Callorhinchus sp.

<400> 16
Gln Lys Ser Gly Asn Ser Trp Arg Arg Lys Lys Met Gln Arg Arg Asn
1               5                   10                  15


Cys Trp His Arg Arg Cys Leu Pro Phe His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 17
<211> 32
<212> PRT
<213> Oncorhynchus sp.

<400> 17
Val Arg Pro Asp Ile Leu Asn Ile Arg Arg Arg Tyr His Arg His His
1               5                   10                  15


Cys Pro His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
            20                  25                  30


<210> 18
<211> 36
<212> PRT
<213> Danio rerio

<400> 18
Asp Lys His Gly Thr Lys His Asp Phe Leu Asn Leu Arg Arg Lys Tyr
1               5                   10                  15


Arg Arg His Asn Cys Pro Lys Lys Arg Cys Leu Pro Leu His Ser Arg
            20                  25                  30


Val Pro Phe Pro
        35


<210> 19
<211> 22
<212> PRT
<213> Homo sapiens

<400> 19
Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser
1               5                   10                  15


Leu Leu Leu Ile Ser Gly
            20


<210> 20
<211> 54
<212> PRT
<213> Homo sapiens

<400> 20
Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser
1               5                   10                  15


Leu Leu Leu Ile Ser Gly Gln Arg Pro Val Asn Leu Thr Met Arg Arg
            20                  25                  30


Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 21
<211> 54
<212> PRT
<213> Peromyscus sp.

<400> 21
Met Arg Phe Gln His Tyr Phe Leu Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Thr Glu Gln Arg Pro Val Asn Phe Pro Lys Lys Arg
            20                  25                  30


Lys Val Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Val Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 22
<211> 54
<212> PRT
<213> Rattus sp.

<400> 22
Met Arg Phe Gln Pro Leu Phe Trp Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Thr Glu Glu Lys Ser Val Asn Phe Pro Arg Arg Arg
            20                  25                  30


Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Ser Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 23
<211> 54
<212> PRT
<213> Mus musculus

<400> 23
Met Arg Phe Gln Pro Leu Phe Trp Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Ser Glu Gln Lys Pro Val Asn Phe Pro Arg Arg Arg
            20                  25                  30


Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 24
<211> 54
<212> PRT
<213> Bos sp.

<400> 24
Met Arg Phe His Gln Phe Phe Leu Leu Phe Val Ile Phe Met Leu Ser
1               5                   10                  15


Leu Leu Leu Ile His Gly Gln Arg Gln Ala Asn Leu Ala Met Arg Arg
            20                  25                  30


Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 25
<211> 54
<212> PRT
<213> Sus sp.

<400> 25
Met Arg Phe Arg Gln Phe Phe Leu Val Phe Phe Ile Phe Met Met Asn
1               5                   10                  15


Leu Leu Leu Ile Cys Gly Gln Arg Pro Ala Asn Leu Ala Val Arg Arg
            20                  25                  30


Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 26
<211> 54
<212> PRT
<213> Dasypus sp.

<400> 26
Met Lys Phe Gln Gln Phe Phe Tyr Val Phe Phe Val Phe Ile Met Ser
1               5                   10                  15


Leu Leu Leu Ile Asn Gly Gln Arg Pro Ala Asn Leu Ala Met Arg Arg
            20                  25                  30


Lys Leu His Arg His Asn Cys Phe Gln Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 27
<211> 54
<212> PRT
<213> Trichosurus sp.

<400> 27
Met Arg Phe Gln Leu Leu Phe Phe Leu Phe Leu Phe Phe Thr Met Gly
1               5                   10                  15


Ile Leu Leu Ile Asp Gly Gln Arg Pro Gly Asn Leu Ala Leu Arg Arg
            20                  25                  30


Lys Pro His Arg His Ile Cys Pro Gln Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 28
<211> 54
<212> PRT
<213> Gallus gallus

<400> 28
Met Arg Leu Arg Arg Leu Leu Cys Val Val Phe Leu Leu Leu Val Ser
1               5                   10                  15


Leu Leu Pro Ala Ala Ala Gln Arg Pro Ala Asn Leu Ala Leu Arg Arg
            20                  25                  30


Lys Leu His Arg His Asn Cys Ser His Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 29
<211> 54
<212> PRT
<213> Gekko sp.

<400> 29
Met Arg Leu Gln Leu Leu Leu Leu Thr Cys Phe Leu Ile Leu Thr Gly
1               5                   10                  15


Val Leu Leu Gly Asn Gly Gln Arg Pro Ala Asn Leu Ser Leu Arg Arg
            20                  25                  30


Lys Leu His Arg Gln His Cys Ser His Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 30
<211> 54
<212> PRT
<213> Anolis sp.

<400> 30
Met Arg Leu Gln Gln Leu Leu Leu Thr Trp Phe Leu Leu Leu Ala Gly
1               5                   10                  15


Ala Leu Leu Ile Asn Gly Gln Arg Pro Ala Asn Leu Ala Ser Arg Arg
            20                  25                  30


Lys Leu His Arg His His Cys Ser His Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 31
<211> 54
<212> PRT
<213> Xenopus laevis

<400> 31
Met Asp Phe Gln Lys Leu Leu Tyr Ala Leu Phe Phe Ile Leu Met Ser
1               5                   10                  15


Leu Leu Leu Ile Asn Gly Gln Lys Pro Ala Asn Leu Ala Gln Arg Arg
            20                  25                  30


Arg Ile His Arg His Asn Cys Phe Leu Lys Arg Cys Ile Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 32
<211> 54
<212> PRT
<213> Ambystoma sp.

<400> 32
Met Lys Trp Gln Lys Leu Leu Ala Ile Leu Phe Trp Ile Leu Met Gly
1               5                   10                  15


Ala Leu Leu Val Asn Gly Gln Arg Pro Val Asn Ala Ala His Arg Arg
            20                  25                  30


Arg Leu His Arg His Asn Cys Ser Leu Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 33
<211> 54
<212> PRT
<213> Oryzias sp.

<400> 33
Met Arg Val Trp Asn Leu Leu Tyr Leu Leu Leu Leu Leu Ala Ala Ala
1               5                   10                  15


Leu Ala Pro Val Phe Ser Ala Arg Pro Asp Phe Leu Asn Leu Arg Arg
            20                  25                  30


Lys Tyr His Arg His His Cys Leu His Arg Arg Cys Met Pro Leu His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 34
<211> 54
<212> PRT
<213> Callorhinchus sp.

<400> 34
Met Arg Phe Gln His Leu Leu His Ile Ile Leu Leu Leu Cys Thr Ser
1               5                   10                  15


Leu Leu Leu Ile Ser Gly Gln Lys Ser Gly Asn Ser Trp Arg Arg Lys
            20                  25                  30


Lys Met Gln Arg Arg Asn Cys Trp His Arg Arg Cys Leu Pro Phe His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 35
<211> 53
<212> PRT
<213> Oncorhynchus sp.

<400> 35
Met Arg Ile Ile Ser Leu Leu Tyr Leu Leu Leu Leu Val Thr Val Leu
1               5                   10                  15


Gly Ser Val Ser Ser Val Arg Pro Asp Ile Leu Asn Ile Arg Arg Arg
            20                  25                  30


Tyr His Arg His His Cys Pro His Arg Arg Cys Met Pro Leu His Ser
        35                  40                  45


Arg Val Pro Phe Pro
    50


<210> 36
<211> 58
<212> PRT
<213> Danio rerio

<400> 36
Met Arg Phe Phe His Pro Leu Tyr Leu Leu Leu Leu Leu Leu Thr Val
1               5                   10                  15


Leu Val Leu Ile Ser Ala Asp Lys His Gly Thr Lys His Asp Phe Leu
            20                  25                  30


Asn Leu Arg Arg Lys Tyr Arg Arg His Asn Cys Pro Lys Lys Arg Cys
        35                  40                  45


Leu Pro Leu His Ser Arg Val Pro Phe Pro
    50                  55


<210> 37
<211> 165
<212> DNA
<213> Homo sapiens

<400> 37
atgagatttc agcaattcct ttttgcattt tttattttta ttatgagtct tctccttatc       60

agcggacaga gaccagttaa tttgaccatg agaagaaaac tgcgcaaaca caattgcctt      120

cagaggagat gtatgcctct ccattcacga gtacccttcc cctga                      165


<210> 38
<211> 165
<212> DNA
<213> Mus musculus

<400> 38
atgcgattcc agcccctttt ttgggtattt tttatttttg ccatgagtct cctttttatc       60

agtgaacaga aaccagttaa ctttcccagg agaagaaaac tatacagaca caactgcttt      120

cgcaggagat gcattccact tcattctcga gtgcccttcc catga                      165


<210> 39
<211> 165
<212> DNA
<213> Gallus gallus

<400> 39
atgaggctcc ggcggctgct gtgcgtcgtg ttcctgctcc tggtcagcct gctacctgcc       60

gccgcgcaga gaccggccaa cctggccctg cgcaggaagc tgcaccgaca caactgctcg      120

caccggcggt gcatgccgct ccactcccgc gtgccctttc cctga                      165


<210> 40
<211> 165
<212> DNA
<213> Xenopus laevis

<400> 40
atggattttc agaaattatt gtatgcctta tttttcattc tgatgagtct actgctgatt       60

aatggccaga aaccagccaa cctcgcacag cgccggagga tacacagaca caactgcttc      120

ctcaagaggt gcataccact acattcaaga gttccatttc catga                      165


<210> 41
<211> 177
<212> DNA
<213> Danio rerio

<400> 41
atgagattct tccacccgct gtatctgctg ctgctgctgc tgacagtgct ggtcctcatc       60

agcgcagata aacatggtac aaaacacgat tttctcaact tgaggcggaa atatcgcaga      120

cacaactgcc cgaagaaacg ctgtctacct cttcactcca gagtaccttt cccttga         177


<210> 42
<211> 2422
<212> DNA
<213> Homo sapiens

<400> 42
atcattaacc ttcctgcaaa acacagctgg cagttctctg aggcttgtca ctagaatgtg       60

aagacagcca cacagatatt gcacagacta tttacagatc gtttggctta cattgagagt      120

cattgctcta cttttgtgcg gtaggaaaat gagatttcag caattccttt ttgcattttt      180

tatttttatt atgagtcttc tccttatcag cggacagaga ccagttaatt tgaccatgag      240

aagaaaactg cgcaaacaca attgccttca gaggagatgt atgcctctcc attcacgagt      300

acccttcccc tgagatctct ctagctaact ttactggatc tatcagaaga agaagaggag      360

tgaaggaaag acacccagcc acacaaaaga acttcatgat gccaacagcg tgattgctta      420

gaagttccta cacaaaaaaa ggatcatttg aaagcacctg gaatggttta ttagcttcac      480

aggattttat tcttcttggc ttctatttgg agggaaaata acataaattc aaaaggattc      540

caatctgaag cccaaattgt ttgcctacat aacaaaaata tctcatcttt tcctgcacat      600

tattattctt ttatgggtta aaaagaaaaa taccttttag tgttttagaa ctctctcatg      660

gtaaaaagtg caagaattta aaatgttgct ttcatattcc tataattctc caaaagtatt      720

aaattcgtat atgtttgagt gattttctaa aaactgctca acctggaatc aattgcattg      780

accatttggc ttcgcacaat agggagaaaa taattggttc attgattata tagagagaaa      840

gactaagaaa agctattaat tgctaccaat tttatgataa gctttaaggt ttatgaaagt      900

atgttttttt atttaatgag taatgtccat ttgaagttga aagaaaacat gaaatcctaa      960

ttgtagttca ttttatgttc aaatgaaacc attgtttttg tttttgtttt gaaacagagt     1020

ctcactctgt tgcccaaggt ggagagaagt ggcacgcttt tgtctcactg caacctccac     1080

ctcccgagtt caagtgattc tcgtgcctca acctcccaat tataggctgg gattacaggt     1140

gtgcaccact acacccagct aattcttgta ttttttgtag agatgaggtt ttaccctgtt     1200

gcccaggctg gtcttgaact caggctggaa ccattcattt tttaaccttt ctcatcatgt     1260

aattatagga acccaacgtt tgatttcctt tgaagttttg ttatgtcctt tattattttg     1320

tatggataat ttctttaaaa gtcttactta aagtcgacat ctaaaataca gttatgccaa     1380

tgaagtccca ctcagggtga tatctgtatc taaaagatga gtgctcatca tcctattagg     1440

ctttgtcttg gtggtgttca tcctgagatg ctgagacatg gaaataaaaa atcagaagga     1500

atttagggat atgattactc aaaaaagaaa ctatcctgtc taaatttgaa ttgtgttgat     1560

aactaggtgt tccccagatg ctaagatgtt cttaatttgt atttattgaa ggattgttag     1620

cttagtgcca caaaattttt cttactttat gttaattcca gataagaaat ttacaagttt     1680

atatcttttt ttttcttttt tttaagatga gatctggctc tatcacccag gctaaagtgc     1740

agtggcatga tctaggctaa ctccctggct caagcgatcc ttccacctca gcctcccaag     1800

tacctgggac tacaggcact cacggccaca cctgactaat ttttgtattt ttttgtagag     1860

atggagtatc gccatgttgc ccaggttggt ctcaaactca ggctggtgag ctcaagtgat     1920

ccgcctcctt ggcctcccaa aatactggga ttacaggcat gtgccaccat gctgggccac     1980

aagttcatat ctggagtaga agttttactt tgtaaatatt ataaagtaga agaaaccata     2040

aaccattttg ctaaaatgaa aggttggggt taatataaat gtaattttaa atagaaaatc     2100

tgacaacact gtcgagtttg tcttcctgtc aaagcttatt aaaagtgtct ttgcggatga     2160

atggtacttt ccacaagtgc atttgagtag aagcataacc tattctcagt tatatttatg     2220

tttaaaacat gtactggttt gtatattttg tactgaaaaa gaaaacactt tatagtcaag     2280

atacatctca ttcaatacaa gtctaaactc tttcaaatac aaattcgcat attcacagaa     2340

aaagttacaa atcagtttta ctattgtaaa gtaatgaaat ggttatacat ttcttaattg     2400

ttcaataaaa cactcaatga tt                                              2422


<210> 43
<211> 975
<212> DNA
<213> Mus musculus

<400> 43
cggactctcc ttggagcttt gcagagactt cccgcttaag ttactgcgtg cctgaatgga       60

aaaggcagct ggcagccctc tgagttctgg ccataggatg tggggtgagc cggacagata      120

ctgcgattta cagacgattt ctctacttga agagctattg ttcacttgcg tgtaagaaaa      180

aagaaaaaca aaaggaaaga aaaagaagaa aagaaaaaag agaaagaaaa gaaaagatgc      240

gattccagcc ccttttttgg gtatttttta tttttgccat gagtctcctt tttatcagtg      300

aacagaaacc agttaacttt cccaggagaa gaaaactata cagacacaac tgctttcgca      360

ggagatgcat tccacttcat tctcgagtgc ccttcccatg aggaaaacct ctaatttcct      420

tggctctacc agaagaaggg tgaaagcaaa gatacccaat caccggaaaa acaacctcag      480

gatggcaaca ggatggcagc tcaggagtta ctacgcaaca gaggctgttt cagagtaccg      540

tggatggctt ttcagactgc tcttcctgga ttctctttga caagaaaatg atagaaaggg      600

aaaacagacg aggttaaagc acatgcgttt gtctgaataa caatctctcc tgctgttctg      660

cacgttcttt gcgtataatg tatgaattac acatagtggt gggtttcaca aaggcattta      720

cataccagta catcacgtcc tatggccgtc tttccacaca tgtgcatcat atacaccgat      780

tctttacagg catgcatgcc atatacactg actacatttg cacacacata ccttcccctt      840

tctctcccct caccctcctg caggtctctt ttattcacct gggcagtttt gtttctattt      900

taatggtttg tacacatgaa tgattttatt gcacattatt attcttacat ggattaaaaa      960

gaaaactact ttaat                                                       975


<210> 44
<211> 482
<212> DNA
<213> Gallus gallus

<400> 44
ggcgagtgcc acggacgctt ctgtacacac gcggaccgca gggatgaggc tccggcggct       60

gctgtgcgtc gtgttcctgc tcctggtcag cctgctacct gccgccgcgc agagaccggc      120

caacctggcc ctgcgcagga agctgcaccg acacaactgc tcgcaccggc ggtgcatgcc      180

gctccactcc cgcgtgccct ttccctgagc gcccggccca gctcggcaag caatttcgta      240

acgggctttt cagtgtctta aaggaggaag ctgcaacaac tgcactgata gagaagctca      300

ttctaagtac tgcttaccaa cagttgacct ggtggagcca cagcaatcct gttttgaggg      360

agtccatctg aaatgaacac tttcagtggt cctgtgtatc acattctgca tgacctggaa      420

caaaggccca tgactcatat cctagaagca gggggaaggg agaaacgggg aaggtgattg      480

gg                                                                     482


<210> 45
<211> 700
<212> DNA
<213> Xenopus laevis

<400> 45
gtttcggtcc ggattcccgg gatccagacc tgatctaata gttgcctatc tctgaagagc       60

aatatggatt ttcagaaatt attgtatgcc ttatttttca ttctgatgag tctactgctg      120

attaatggcc agaaaccagc caacctcgca cagcgccgga ggatacacag acacaactgc      180

ttcctcaaga ggtgcatacc actacattca agagttccat ttccatgaga ccactgagga      240

atctcatcat gatgtaacat aggatctgac tcaaatctac agaaataata tttattttga      300

acagtgttta agttgttctt tgacttataa gtggatgttt cttaaatgag ctgcccacaa      360

gaatgggcac agacaagctc caacccatgt aactggctgt gaaactggca caggagctgc      420

cgaaagcaat gtccctccat gaaactgatc caggagacat ctacagcaac ctttgttcca      480

ccaaaacaga caagagagca gattctccat cacattccaa ggaagtgaat gttcaaaggc      540

ttgcatttat tatcaaactg aaatgaagca tatcataata aggctcaatg tcctgtacct      600

caaaagattt aaaatatggg gataaaatga agaaaaacag aagatggttt ttggacaatc      660

tggtcatatt tttaaatatt gccccgtgtg caaaaaaaga                            700


<210> 46
<211> 849
<212> DNA
<213> Danio rerio

<400> 46
catcaggtca tctgtctatc tatccatccc tcagaggaca gagagagaag agagagtgaa       60

tatcgccatc tcaaactttg aaaaagttgg agagaccgag agctggctag aactgcgcgt      120

cttctatata actcaactta tacgagatct gagaacactt gctgagagcg acagacacat      180

aagaggattt ctacagtccg ttacctgcac atccgacaga atttatcgtc tgaggaaccg      240

cggacatcct gtgaggagag tcgagtctgc gccgcggacc aaaccaccct gagcatcacc      300

atgagattct tccacccgct gtatctgctg ctgctgctgc tgacagtgct ggtcctcatc      360

agcgcagata aacatggtac aaaacacgat tttctcaact tgaggcggaa atatcgcaga      420

cacaactgcc cgaagaaacg ctgtctacct cttcactcca gagtaccttt cccttgaggt      480

tttatgatgc tccgggcaag cattaagaaa aaccaaagac cagccttgga ttggaaatga      540

gaaaagattt atgtcagatg tgccgaggac tgttttattc gcacatgtat tgtaatcaaa      600

gccatgtttg tcacttctgt agcagaagtg ttttttgttt tgttttgttt tttaaatgaa      660

tgtaagtgaa tgagccatgg agatcctact gctgccaaac atgctgcaaa ctcatcactc      720

aatcaggttg agttggagca gaatcattgt aaatagtgag gactgaatga aatgtgttta      780

tatgtaagtt atgcacttca aatgttttat tattatcttg atttattaaa agtgtattgt      840

cttttcaga                                                              849


<210> 47
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Anti-ELABELA shRNA sequence A oligonucleotide

<400> 47
gacacccagc cacacaaaa                                                    19


<210> 48
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Anti-ELABELA shRNA sequence B oligonucleotide

<400> 48
cccagccaca caaaagaac                                                    19


<210> 49
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Anti-ELABELA shRNA sequence C oligonucleotide

<400> 49
gtgattctcg tgcctcaac                                                    19


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Anti-ELABELA shRNA sequence D oligonucleotide

<400> 50
ctcacggcca cacctgact                                                    19


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Anti-ELABELA shRNA sequence E oligonucleotide

<400> 51
ttgccttcag aggagatgt                                                    19


<210> 52
<211> 11
<212> PRT
<213> Homo sapiens

<400> 52
Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10


<210> 53
<211> 17
<212> PRT
<213> Homo sapiens

<400> 53
Gln Arg Pro Val Asn Leu Thr Met Arg Arg Lys Leu Arg Lys His Asn
1               5                   10                  15


Cys



<210> 54
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide

<400> 54
Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10


<210> 55
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide

<400> 55
Gln Arg Pro Val Asn Leu Thr Met Arg Arg Lys Leu Arg Lys His Asn
1               5                   10                  15


<210> 56
<211> 54
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      consensus polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg, Lys or Asp

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Phe, Leu, Trp or Val

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Gln, His, Arg or Trp

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Gln, His, Pro, Leu, Arg, Lys or Asn

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Tyr or Leu

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Leu or Phe

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Phe, Leu, Trp, Tyr, Cys, Ala or His

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Val, Leu, Thr or Ile

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Phe, Val, Cys, Trp, Leu or Ile

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Phe, Val or Leu

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ile, Val, Phe, Leu or Trp

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Phe, Leu or Ile

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ile, Ala, Met, Thr, Leu or Cys

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Met, Leu, Val, Thr or Ala

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Asn, Gly or Ala

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Leu, Ile, Val or Ala

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Leu or Ala

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Leu, Phe or Pro

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ile, Ala, Gly or Val

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ser, Thr, His, Cys, Asn, Asp, Ala or Phe

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Gly, Glu, Ala or Ser

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gln, Glu or Ala

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Pro, Ser or Gln

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Val, Ala, Gly or Asp

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asn or Phe

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Leu, Phe, Ala or Ser

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Thr, Pro, Ala, Ser, Asn or Trp

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Met, Lys, Arg, Val, Leu, Ser, Gln or His

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Leu, Val, Pro, Ile, Tyr or Met

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Arg, Tyr, His or Gln

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (37)..(37)
<223> His, Gln or Arg

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Asn, Ile or His

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Leu, Phe, Pro, Ser or Trp

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Gln, Arg, His or Leu

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Met, Val, Ile or Leu

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Pro or Ser

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Leu or Phe

<400> 56
Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1               5                   10                  15


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa Xaa His
        35                  40                  45


Ser Arg Val Pro Phe Pro
    50


<210> 57
<211> 4
<212> PRT
<213> Danio rerio

<400> 57
Asp Lys His Gly
1


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      ELABELA polypeptide signature sequence

<400> 58
His Ser Arg Val Pro Phe Pro
1               5


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      ELABELA polypeptide signature sequence


<220>
<221> MOD_RES
<222> (3)..(5)
<223> Any amino acid

<400> 59
Arg Cys Xaa Xaa Xaa His Ser Arg Val Pro Phe Pro
1               5                   10


<210> 60
<211> 16
<212> PRT
<213> Homo sapiens

<400> 60
Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 61
<211> 16
<212> PRT
<213> Peromyscus sp.

<400> 61
Cys Phe Arg Arg Arg Cys Val Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 62
<211> 16
<212> PRT
<213> Rattus sp.

<400> 62
Cys Phe Arg Arg Arg Cys Ile Ser Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 63
<211> 16
<212> PRT
<213> Mus musculus

<400> 63
Cys Phe Arg Arg Arg Cys Ile Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 64
<211> 16
<212> PRT
<213> Bos sp.

<400> 64
Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 65
<211> 16
<212> PRT
<213> Sus sp.

<400> 65
Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 66
<211> 16
<212> PRT
<213> Dasypus sp.

<400> 66
Cys Phe Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 67
<211> 16
<212> PRT
<213> Trichosurus sp.

<400> 67
Cys Pro Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 68
<211> 16
<212> PRT
<213> Gallus gallus

<400> 68
Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 69
<211> 16
<212> PRT
<213> Gekko sp.

<400> 69
Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 70
<211> 16
<212> PRT
<213> Anolis sp.

<400> 70
Cys Ser His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 71
<211> 16
<212> PRT
<213> Xenopus laevis

<400> 71
Cys Phe Leu Lys Arg Cys Ile Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 72
<211> 16
<212> PRT
<213> Ambystoma sp.

<400> 72
Cys Ser Leu Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 73
<211> 16
<212> PRT
<213> Oryzias sp.

<400> 73
Cys Leu His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 74
<211> 16
<212> PRT
<213> Callorhinchus sp.

<400> 74
Cys Trp His Arg Arg Cys Leu Pro Phe His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 75
<211> 16
<212> PRT
<213> Oncorhynchus sp.

<400> 75
Cys Pro His Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 76
<211> 16
<212> PRT
<213> Danio rerio

<400> 76
Cys Pro Lys Lys Arg Cys Leu Pro Leu His Ser Arg Val Pro Phe Pro
1               5                   10                  15


<210> 77
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (2)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(16)
<223> Any amino acid

<400> 77
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa Xaa
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 78
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (2)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 78
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 79
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (3)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 79
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 80
<211> 22
<212> PRT
<213> Peromyscus sp.

<400> 80
Met Arg Phe Gln His Tyr Phe Leu Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Thr Glu
            20


<210> 81
<211> 22
<212> PRT
<213> Rattus sp.

<400> 81
Met Arg Phe Gln Pro Leu Phe Trp Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Thr Glu
            20


<210> 82
<211> 22
<212> PRT
<213> Mus musculus

<400> 82
Met Arg Phe Gln Pro Leu Phe Trp Val Phe Phe Ile Phe Ala Met Ser
1               5                   10                  15


Leu Leu Phe Ile Ser Glu
            20


<210> 83
<211> 22
<212> PRT
<213> Bos sp.

<400> 83
Met Arg Phe His Gln Phe Phe Leu Leu Phe Val Ile Phe Met Leu Ser
1               5                   10                  15


Leu Leu Leu Ile His Gly
            20


<210> 84
<211> 22
<212> PRT
<213> Sus sp.

<400> 84
Met Arg Phe Arg Gln Phe Phe Leu Val Phe Phe Ile Phe Met Met Asn
1               5                   10                  15


Leu Leu Leu Ile Cys Gly
            20


<210> 85
<211> 22
<212> PRT
<213> Dasypus sp.

<400> 85
Met Lys Phe Gln Gln Phe Phe Tyr Val Phe Phe Val Phe Ile Met Ser
1               5                   10                  15


Leu Leu Leu Ile Asn Gly
            20


<210> 86
<211> 22
<212> PRT
<213> Trichosurus sp.

<400> 86
Met Arg Phe Gln Leu Leu Phe Phe Leu Phe Leu Phe Phe Thr Met Gly
1               5                   10                  15


Ile Leu Leu Ile Asp Gly
            20


<210> 87
<211> 22
<212> PRT
<213> Gallus gallus

<400> 87
Met Arg Leu Arg Arg Leu Leu Cys Val Val Phe Leu Leu Leu Val Ser
1               5                   10                  15


Leu Leu Pro Ala Ala Ala
            20


<210> 88
<211> 22
<212> PRT
<213> Gekko sp.

<400> 88
Met Arg Leu Gln Leu Leu Leu Leu Thr Cys Phe Leu Ile Leu Thr Gly
1               5                   10                  15


Val Leu Leu Gly Asn Gly
            20


<210> 89
<211> 22
<212> PRT
<213> Anolis sp.

<400> 89
Met Arg Leu Gln Gln Leu Leu Leu Thr Trp Phe Leu Leu Leu Ala Gly
1               5                   10                  15


Ala Leu Leu Ile Asn Gly
            20


<210> 90
<211> 22
<212> PRT
<213> Xenopus laevis

<400> 90
Met Asp Phe Gln Lys Leu Leu Tyr Ala Leu Phe Phe Ile Leu Met Ser
1               5                   10                  15


Leu Leu Leu Ile Asn Gly
            20


<210> 91
<211> 22
<212> PRT
<213> Ambystoma sp.

<400> 91
Met Lys Trp Gln Lys Leu Leu Ala Ile Leu Phe Trp Ile Leu Met Gly
1               5                   10                  15


Ala Leu Leu Val Asn Gly
            20


<210> 92
<211> 22
<212> PRT
<213> Oryzias sp.

<400> 92
Met Arg Val Trp Asn Leu Leu Tyr Leu Leu Leu Leu Leu Ala Ala Ala
1               5                   10                  15


Leu Ala Pro Val Phe Ser
            20


<210> 93
<211> 22
<212> PRT
<213> Callorhinchus sp.

<400> 93
Met Arg Phe Gln His Leu Leu His Ile Ile Leu Leu Leu Cys Thr Ser
1               5                   10                  15


Leu Leu Leu Ile Ser Gly
            20


<210> 94
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (3)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 94
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 95
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (3)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 95
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 96
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (3)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 96
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 97
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 97
His His His His His His
1               5


<210> 98
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 98
agcaaaaccc ggaggagt                                                     18


<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 99
cacgagtacc ctttccctga                                                   20


<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 100
tccagcagat gcaagaactc                                                   20


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 101
ggaagcccaa gaacctgaat                                                   20


<210> 102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 102
aatacttccc ccacaacaca a                                                 21


<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 103
cgccctactc gtacatctcg                                                   20


<210> 104
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 104
gtggggaggt cgaggttc                                                     18


<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 105
gctgtgacag gtacccaacc                                                   20


<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 106
tgcgggctac tgaaaagttc                                                   20


<210> 107
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 107
agccacatcg ctcagacac                                                    19


<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 108
atcttgaccc tccctggaat                                                   20


<210> 109
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 109
aatgggcgga gttatgatac c                                                 21


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 110
gatcttcact ccccttgttc a                                                 21


<210> 111
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 111
gctgtgttca gccagtgct                                                    19


<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 112
cgtctgctac tgcttcatcg                                                   20


<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 113
cctcttgcgc tatggacttc                                                   20


<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 114
ttcttccacc cgctgtatct                                                   20


<210> 115
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 115
ccacatcggc ctgtgtatat c                                                 21


<210> 116
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 116
ggctgggtgt ctttccttc                                                    19


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 117
ttgctattct tcggccagtt                                                   20


<210> 118
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 118
gctggagttg ctggaagc                                                     18


<210> 119
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 119
ctctcccgca ccagtcat                                                     18


<210> 120
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 120
agcgtcagca tcttgttgg                                                    19


<210> 121
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 121
tgttctggag gtccatggta g                                                 21


<210> 122
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 122
catgcaggtg agttgtcaga a                                                 21


<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 123
tgtaggccct gtttctcctg                                                   20


<210> 124
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 124
gcccaatacg accaaatcc                                                    19


<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 125
atggggagac taggctgtga                                                   20


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 126
catatcaggt tcacttccgg g                                                 21


<210> 127
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 127
ggcagcgatt tcctcatc                                                     18


<210> 128
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 128
ttctgccgca aaggagtc                                                     18


<210> 129
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 129
gctttttctg gtcttccttg c                                                 21


<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 130
gcctgcaatc cagtaggtct                                                   20


<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 131
ccggagcatc ataaaacctc                                                   20


<210> 132
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
gtgattctcg tgcctcaac                                                    19


<210> 133
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 133
tccacccgct gtatct                                                       16


<210> 134
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 134
gctgctgctg acagt                                                        15


<210> 135
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 135
aacacttgct gagagcgaca g                                                 21


<210> 136
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 136
agatgtggtg gtgttgagta gc                                                22


<210> 137
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 137
atggagccaa cgccggaat                                                    19


<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 138
atgaatgcca tggacaacat                                                   20


<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 139
acacacatcc cagccttttc                                                   20


<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 140
ccatccctca gaggacagag                                                   20


<210> 141
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 141
tcacactttg gtggccagc                                                    19


<210> 142
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 142
tcacaccttc gtagccagc                                                    19


<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 143
ccaatttcat tcggcaatct                                                   20


<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 144
catgtttggc agcagtagga                                                   20


<210> 145
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 145
ctttgtggtg accctgcccc tgttggccgt ctacactgct ctg                         43


<210> 146
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 146
cagagcagtg tagacggcca acaggggcag ggtcaccaca aag                         43


<210> 147
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 147
atggaggaag gtggtgattt tga                                               23


<210> 148
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 148
atggacccag aagaaacttc ag                                                22


<210> 149
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 149
atgagattct tccacccgc                                                    19


<210> 150
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 150
ggagaccctt gtggttgact ag                                                22


<210> 151
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 151
ttagagtgac acagacctct tcc                                               23


<210> 152
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 152
tcaagggaaa ggtactctgg ag                                                22


<210> 153
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 153
acacgtaccg ggactatga                                                    19


<210> 154
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 154
ccatcatgct gacctgtta                                                    19


<210> 155
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 155
gacctctgcg cctaattat                                                    19


<210> 156
<211> 57
<212> DNA
<213> Danio rerio

<400> 156
atgagattct tccacccgct gtatctgctg ctgctgctgc tgacagtgct ggtcctc          57


<210> 157
<211> 51
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Met Arg Phe Phe His Pro Leu Tyr Leu Leu Val Leu Ile Ser Ala Asp
1               5                   10                  15


Lys His Gly Thr Lys His Asp Phe Leu Asn Leu Arg Arg Lys Tyr Arg
            20                  25                  30


Arg His Asn Cys Pro Lys Lys Arg Cys Leu Pro Leu His Ser Arg Val
        35                  40                  45


Pro Phe Pro
    50


<210> 158
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 158
Met Arg Phe Phe His Pro Leu Tyr Leu Cys Gln Cys Trp Ser Ser Ser
1               5                   10                  15


Ala Gln Ile Asn Met Val Gln Asn Thr Ile Phe Ser Thr
            20                  25


<210> 159
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 159
Met Arg Phe Phe His Pro Leu
1               5


<210> 160
<211> 33
<212> PRT
<213> Homo sapiens

<400> 160
Gly Gln Arg Pro Val Asn Leu Thr Met Arg Arg Lys Leu Arg Lys His
1               5                   10                  15


Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His Ser Arg Val Pro Phe
            20                  25                  30


Pro



<210> 161
<211> 36
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      apelin peptide

<400> 161
Leu Val Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly
1               5                   10                  15


Gly Arg Arg Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly
            20                  25                  30


Pro Met Pro Phe
        35


<210> 162
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(16)
<223> Any amino acid

<400> 162
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa Xaa
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 163
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      ELABELA peptide


<220>
<221> MOD_RES
<222> (1)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<400> 163
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Arg Cys Xaa Xaa
1               5                   10                  15


Xaa His Ser Arg Val Pro Phe Pro
            20


<210> 164
<211> 24
<212> PRT
<213> Homo sapiens

<400> 164
Arg Arg Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 165
<211> 24
<212> PRT
<213> Peromyscus sp.

<400> 165
Lys Arg Lys Val Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Val Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 166
<211> 24
<212> PRT
<213> Rattus sp.

<400> 166
Arg Arg Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Ser
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 167
<211> 24
<212> PRT
<213> Mus musculus

<400> 167
Arg Arg Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 168
<211> 24
<212> PRT
<213> Bos sp.

<400> 168
Arg Arg Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 169
<211> 24
<212> PRT
<213> Sus sp.

<400> 169
Arg Arg Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 170
<211> 24
<212> PRT
<213> Dasypus sp.

<400> 170
Arg Arg Lys Leu His Arg His Asn Cys Phe Gln Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 171
<211> 24
<212> PRT
<213> Trichosurus sp.

<400> 171
Arg Arg Lys Pro His Arg His Ile Cys Pro Gln Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 172
<211> 24
<212> PRT
<213> Gallus gallus

<400> 172
Arg Arg Lys Leu His Arg His Asn Cys Ser His Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 173
<211> 24
<212> PRT
<213> Gekko sp.

<400> 173
Arg Arg Lys Leu His Arg Gln His Cys Ser His Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 174
<211> 24
<212> PRT
<213> Anolis sp.

<400> 174
Arg Arg Lys Leu His Arg His His Cys Ser His Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 175
<211> 24
<212> PRT
<213> Xenopus laevis

<400> 175
Arg Arg Arg Ile His Arg His Asn Cys Phe Leu Lys Arg Cys Ile Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 176
<211> 24
<212> PRT
<213> Ambystoma sp.

<400> 176
Arg Arg Arg Leu His Arg His Asn Cys Ser Leu Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 177
<211> 24
<212> PRT
<213> Oryzias sp.

<400> 177
Arg Arg Lys Tyr His Arg His His Cys Leu His Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 178
<211> 24
<212> PRT
<213> Callorhinchus sp.

<400> 178
Arg Lys Lys Met Gln Arg Arg Asn Cys Trp His Arg Arg Cys Leu Pro
1               5                   10                  15


Phe His Ser Arg Val Pro Phe Pro
            20


<210> 179
<211> 24
<212> PRT
<213> Oncorhynchus sp.

<400> 179
Arg Arg Arg Tyr His Arg His His Cys Pro His Arg Arg Cys Met Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 180
<211> 24
<212> PRT
<213> Danio rerio

<400> 180
Arg Arg Lys Tyr Arg Arg His Asn Cys Pro Lys Lys Arg Cys Leu Pro
1               5                   10                  15


Leu His Ser Arg Val Pro Phe Pro
            20


<210> 181
<211> 23
<212> PRT
<213> Homo sapiens

<400> 181
Arg Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 182
<211> 23
<212> PRT
<213> Peromyscus sp.

<400> 182
Arg Lys Val Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Val Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 183
<211> 23
<212> PRT
<213> Rattus sp.

<400> 183
Arg Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Ser Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 184
<211> 23
<212> PRT
<213> Mus musculus

<400> 184
Arg Lys Leu Tyr Arg His Asn Cys Phe Arg Arg Arg Cys Ile Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 185
<211> 23
<212> PRT
<213> Bos sp.

<400> 185
Arg Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 186
<211> 23
<212> PRT
<213> Sus sp.

<400> 186
Arg Lys Leu His Arg His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 187
<211> 23
<212> PRT
<213> Dasypus sp.

<400> 187
Arg Lys Leu His Arg His Asn Cys Phe Gln Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 188
<211> 23
<212> PRT
<213> Trichosurus sp.

<400> 188
Arg Lys Pro His Arg His Ile Cys Pro Gln Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 189
<211> 23
<212> PRT
<213> Gallus gallus

<400> 189
Arg Lys Leu His Arg His Asn Cys Ser His Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 190
<211> 23
<212> PRT
<213> Gekko sp.

<400> 190
Arg Lys Leu His Arg Gln His Cys Ser His Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 191
<211> 23
<212> PRT
<213> Anolis sp.

<400> 191
Arg Lys Leu His Arg His His Cys Ser His Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 192
<211> 23
<212> PRT
<213> Xenopus laevis

<400> 192
Arg Arg Ile His Arg His Asn Cys Phe Leu Lys Arg Cys Ile Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 193
<211> 23
<212> PRT
<213> Ambystoma sp.

<400> 193
Arg Arg Leu His Arg His Asn Cys Ser Leu Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 194
<211> 23
<212> PRT
<213> Oryzias sp.

<400> 194
Arg Lys Tyr His Arg His His Cys Leu His Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 195
<211> 23
<212> PRT
<213> Callorhinchus sp.

<400> 195
Lys Lys Met Gln Arg Arg Asn Cys Trp His Arg Arg Cys Leu Pro Phe
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 196
<211> 23
<212> PRT
<213> Oncorhynchus sp.

<400> 196
Arg Arg Tyr His Arg His His Cys Pro His Arg Arg Cys Met Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


<210> 197
<211> 23
<212> PRT
<213> Danio rerio

<400> 197
Arg Lys Tyr Arg Arg His Asn Cys Pro Lys Lys Arg Cys Leu Pro Leu
1               5                   10                  15


His Ser Arg Val Pro Phe Pro
            20


