                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       EREZ, Ayelet
       STETTNER, Noa
 
<120>  COMBINATION THERAPY TO INCREASE ENDOGENOUS NITRIC OXIDE (NO) 
       SYNTHESIS

<130>  70420

<150>  IL 246722
<151>  2016-07-11

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
1               5                   10                  15      


Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
            20                  25                  30          


His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
        35                  40                  45              


Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
    50                  55                  60                  


His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
65                  70                  75                  80  


Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                85                  90                  95      


Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
            100                 105                 110         


Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
        115                 120                 125             


Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
    130                 135                 140                 


Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
145                 150                 155                 160 


Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                165                 170                 175     


Ala Val Ala Leu Thr Arg Asp Ser Glu Arg Leu Leu Glu Val Arg Lys 
            180                 185                 190         


Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
        195                 200                 205             


Leu Gly Val Asp Arg Glu Leu Leu Arg Ala Glu Leu Asn Phe Gly Ala 
    210                 215                 220                 


Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
225                 230                 235                 240 


Glu Phe Leu Phe Trp Ala Ser Leu Cys Met Thr His Leu Ser Arg Met 
                245                 250                 255     


Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys Glu Phe Ser Phe Val Gln 
            260                 265                 270         


Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
        275                 280                 285             


Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Gly Arg Val Phe 
    290                 295                 300                 


Gly Arg Cys Ala Gly Leu Leu Met Thr Leu Lys Gly Leu Pro Ser Thr 
305                 310                 315                 320 


Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu Ala Val Phe Glu Val Ser 
                325                 330                 335     


Asp Thr Met Ser Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr 
            340                 345                 350         


Leu Gln Ile His Gln Glu Asn Met Gly Gln Ala Leu Ser Pro Asp Met 
        355                 360                 365             


Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe 
    370                 375                 380                 


Arg Gln Ala His Glu Ala Ser Gly Lys Ala Val Phe Met Ala Glu Thr 
385                 390                 395                 400 


Lys Gly Val Ala Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Ile 
                405                 410                 415     


Ser Pro Leu Phe Ser Gly Asp Val Ile Cys Val Trp Asp Tyr Gly His 
            420                 425                 430         


Ser Val Glu Gln Tyr Gly Ala Leu Gly Gly Thr Ala Arg Ser Ser Val 
        435                 440                 445             


Asp Trp Gln Ile Arg Gln Val Arg Ala Leu Leu Gln Ala Gln Gln Ala 
    450                 455                 460                 


<210>  2
<211>  2061
<212>  DNA
<213>  Homo sapiens

<400>  2
ccaggcggag gtgagtgcgc ggcggccgga tgggcgggac gggcgtggag gacgccgagc       60

accgtggcgc gcgctcacgt ccgcgtcccc aagggctgcg ctccctcaag cgcagtgccc      120

agaactcgga gccagcccgg cccgggggac cctgctggcc aaggaggtcg tcagtccggt      180

cttgtcttcc agacccggag gaccgaagct tccggacgac gaggaaccgc ccaacatggc      240

ctcggagagt gggaagcttt ggggtggccg gtttgtgggt gcagtggacc ccatcatgga      300

gaagttcaac gcgtccattg cctacgaccg gcacctttgg gaggtggatg ttcaaggcag      360

caaagcctac agcaggggcc tggagaaggc agggctcctc accaaggccg agatggacca      420

gatactccat ggcctagaca aggtggctga ggagtgggcc cagggcacct tcaaactgaa      480

ctccaatgat gaggacatcc acacagccaa tgagcgccgc ctgaaggagc tcattggtgc      540

aacggcaggg aagctgcaca cgggacggag ccggaatgac caggtggtca cagacctcag      600

gctgtggatg cggcagacct gctccacgct ctcgggcctc ctctgggagc tcattaggac      660

catggtggat cgggcagagg cggaacgtga tgttctcttc ccggggtaca cccatttgca      720

gagggcccag cccatccgct ggagccactg gattctgagc cacgccgtgg cactgacccg      780

agactctgag cggctgctgg aggtgcggaa gcggatcaat gtcctgcccc tggggagtgg      840

ggccattgca ggcaatcccc tgggtgtgga ccgagagctg ctccgagcag aactcaactt      900

tggggccatc actctcaaca gcatggatgc cactagtgag cgggactttg tggccgagtt      960

cctgttctgg gcttcgctgt gcatgaccca tctcagcagg atggccgagg acctcatcct     1020

ctactgcacc aaggaattca gcttcgtgca gctctcagat gcctacagca cgggaagcag     1080

cctgatgccc cagaagaaaa accccgacag tttggagctg atccggagca aggctgggcg     1140

tgtgtttggg cggtgtgccg ggctcctgat gaccctcaag ggacttccca gcacctacaa     1200

caaagactta caggaggaca aggaagctgt gtttgaagtg tcagacacta tgagtgccgt     1260

gctccaggtg gccactggcg tcatctctac gctgcagatt caccaagaga acatgggaca     1320

ggctctcagc cccgacatgc tggccactga ccttgcctat tacctggtcc gcaaagggat     1380

gccattccgc caggcccacg aggcctccgg gaaagctgtg ttcatggccg agaccaaggg     1440

ggtcgccctc aaccagctgt cactgcagga gctgcagacc atcagccccc tgttctcggg     1500

cgacgtgatc tgcgtgtggg actacgggca cagtgtggag cagtatggtg ccctgggcgg     1560

cactgcgcgc tccagcgtcg actggcagat ccgccaggtg cgggcgctac tgcaggcaca     1620

gcaggcctag gtcctcccac acctgccccc taataaagtg ggcgcgagag gaggctgctg     1680

tgtgtttcct gccccagcct ggctccctcg ttgctgggct ttcggggctg gccagtgggg     1740

acagtcaggg actggagagg cagggcaggg tggcctgtaa tcccagcact ttggaagggc     1800

aaggtgcgag gatgcttgag gccaggagtt tgacacagcc tgggcaacac agggagaccc     1860

ccatctctac tcaataataa aacaaatagc ctggcgtggt ggcccatgca tatagtccca     1920

gctacttgta aggctgaggt gagaggacac ttgtgcccag gagtggaggc tgcagtgagc     1980

tatgatcacg ccactgcatt ccagcctgga taacagagtg agaacctatc tctaaaaata     2040

aataaataaa cgaaaaataa a                                               2061


<210>  3
<211>  1937
<212>  DNA
<213>  Homo sapiens

<400>  3
gacgccatcc cggccagaaa agccctggcc agtggcgggc gcgacactat ccgtgcggcc       60

aggcggagac ccggaggacc gaagcttccg gacgacgagg aaccgcccaa catggcctcg      120

gagagtggga agctttgggg tggccggttt gtgggtgcag tggaccccat catggagaag      180

ttcaacgcgt ccattgccta cgaccggcac ctttgggagg tggatgttca aggcagcaaa      240

gcctacagca ggggcctgga gaaggcaggg ctcctcacca aggccgagat ggaccagata      300

ctccatggcc tagacaaggt ggctgaggag tgggcccagg gcaccttcaa actgaactcc      360

aatgatgagg acatccacac agccaatgag cgccgcctga aggagctcat tggtgcaacg      420

gcagggaagc tgcacacggg acggagccgg aatgaccagg tggtcacaga cctcaggctg      480

tggatgcggc agacctgctc cacgctctcg ggcctcctct gggagctcat taggaccatg      540

gtggatcggg cagaggcgga acgtgatgtt ctcttcccgg ggtacaccca tttgcagagg      600

gcccagccca tccgctggag ccactggatt ctgagccacg ccgtggcact gacccgagac      660

tctgagcggc tgctggaggt gcggaagcgg atcaatgtcc tgcccctggg gagtggggcc      720

attgcaggca atcccctggg tgtggaccga gagctgctcc gagcagaact caactttggg      780

gccatcactc tcaacagcat ggatgccact agtgagcggg actttgtggc cgagttcctg      840

ttctgggctt cgctgtgcat gacccatctc agcaggatgg ccgaggacct catcctctac      900

tgcaccaagg aattcagctt cgtgcagctc tcagatgcct acagcacggg aagcagcctg      960

atgccccaga agaaaaaccc cgacagtttg gagctgatcc ggagcaaggc tgggcgtgtg     1020

tttgggcggt gtgccgggct cctgatgacc ctcaagggac ttcccagcac ctacaacaaa     1080

gacttacagg aggacaagga agctgtgttt gaagtgtcag acactatgag tgccgtgctc     1140

caggtggcca ctggcgtcat ctctacgctg cagattcacc aagagaacat gggacaggct     1200

ctcagccccg acatgctggc cactgacctt gcctattacc tggtccgcaa agggatgcca     1260

ttccgccagg cccacgaggc ctccgggaaa gctgtgttca tggccgagac caagggggtc     1320

gccctcaacc agctgtcact gcaggagctg cagaccatca gccccctgtt ctcgggcgac     1380

gtgatctgcg tgtgggacta cgggcacagt gtggagcagt atggtgccct gggcggcact     1440

gcgcgctcca gcgtcgactg gcagatccgc caggtgcggg cgctactgca ggcacagcag     1500

gcctaggtcc tcccacacct gccccctaat aaagtgggcg cgagaggagg ctgctgtgtg     1560

tttcctgccc cagcctggct ccctcgttgc tgggctttcg gggctggcca gtggggacag     1620

tcagggactg gagaggcagg gcagggtggc ctgtaatccc agcactttgg aagggcaagg     1680

tgcgaggatg cttgaggcca ggagtttgac acagcctggg caacacaggg agacccccat     1740

ctctactcaa taataaaaca aatagcctgg cgtggtggcc catgcatata gtcccagcta     1800

cttgtaaggc tgaggtgaga ggacacttgt gcccaggagt ggaggctgca gtgagctatg     1860

atcacgccac tgcattccag cctggataac agagtgagaa cctatctcta aaaataaata     1920

aataaacgaa aaataaa                                                    1937


<210>  4
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
1               5                   10                  15      


Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
            20                  25                  30          


His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
        35                  40                  45              


Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
    50                  55                  60                  


His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
65                  70                  75                  80  


Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                85                  90                  95      


Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
            100                 105                 110         


Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
        115                 120                 125             


Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
    130                 135                 140                 


Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
145                 150                 155                 160 


Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                165                 170                 175     


Ala Val Ala Leu Thr Arg Asp Ser Glu Arg Leu Leu Glu Val Arg Lys 
            180                 185                 190         


Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
        195                 200                 205             


Leu Gly Val Asp Arg Glu Leu Leu Arg Ala Glu Leu Asn Phe Gly Ala 
    210                 215                 220                 


Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
225                 230                 235                 240 


Glu Phe Leu Phe Trp Ala Ser Leu Cys Met Thr His Leu Ser Arg Met 
                245                 250                 255     


Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys Glu Phe Ser Phe Val Gln 
            260                 265                 270         


Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
        275                 280                 285             


Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Gly Arg Val Phe 
    290                 295                 300                 


Gly Arg Glu Asp Lys Glu Ala Val Phe Glu Val Ser Asp Thr Met Ser 
305                 310                 315                 320 


Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr Leu Gln Ile His 
                325                 330                 335     


Gln Glu Asn Met Gly Gln Ala Leu Ser Pro Asp Met Leu Ala Thr Asp 
            340                 345                 350         


Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe Arg Gln Ala His 
        355                 360                 365             


Glu Ala Ser Gly Lys Ala Val Phe Met Ala Glu Thr Lys Gly Val Ala 
    370                 375                 380                 


Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Ile Ser Pro Leu Phe 
385                 390                 395                 400 


Ser Gly Asp Val Ile Cys Val Trp Asp Tyr Gly His Ser Val Glu Gln 
                405                 410                 415     


Tyr Gly Ala Leu Gly Gly Thr Ala Arg Ser Ser Val Asp Trp Gln Ile 
            420                 425                 430         


Arg Gln Val Arg Ala Leu Leu Gln Ala Gln Gln Ala 
        435                 440                 


<210>  5
<211>  2001
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaggcggag gtgagtgcgc ggcggccgga tgggcgggac gggcgtggag gacgccgagc       60

accgtggcgc gcgctcacgt ccgcgtcccc aagggctgcg ctccctcaag cgcagtgccc      120

agaactcgga gccagcccgg cccgggggac cctgctggcc aaggaggtcg tcagtccggt      180

cttgtcttcc agacccggag gaccgaagct tccggacgac gaggaaccgc ccaacatggc      240

ctcggagagt gggaagcttt ggggtggccg gtttgtgggt gcagtggacc ccatcatgga      300

gaagttcaac gcgtccattg cctacgaccg gcacctttgg gaggtggatg ttcaaggcag      360

caaagcctac agcaggggcc tggagaaggc agggctcctc accaaggccg agatggacca      420

gatactccat ggcctagaca aggtggctga ggagtgggcc cagggcacct tcaaactgaa      480

ctccaatgat gaggacatcc acacagccaa tgagcgccgc ctgaaggagc tcattggtgc      540

aacggcaggg aagctgcaca cgggacggag ccggaatgac caggtggtca cagacctcag      600

gctgtggatg cggcagacct gctccacgct ctcgggcctc ctctgggagc tcattaggac      660

catggtggat cgggcagagg cggaacgtga tgttctcttc ccggggtaca cccatttgca      720

gagggcccag cccatccgct ggagccactg gattctgagc cacgccgtgg cactgacccg      780

agactctgag cggctgctgg aggtgcggaa gcggatcaat gtcctgcccc tggggagtgg      840

ggccattgca ggcaatcccc tgggtgtgga ccgagagctg ctccgagcag aactcaactt      900

tggggccatc actctcaaca gcatggatgc cactagtgag cgggactttg tggccgagtt      960

cctgttctgg gcttcgctgt gcatgaccca tctcagcagg atggccgagg acctcatcct     1020

ctactgcacc aaggaattca gcttcgtgca gctctcagat gcctacagca cgggaagcag     1080

cctgatgccc cagaagaaaa accccgacag tttggagctg atccggagca aggctgggcg     1140

tgtgtttggg cgggaggaca aggaagctgt gtttgaagtg tcagacacta tgagtgccgt     1200

gctccaggtg gccactggcg tcatctctac gctgcagatt caccaagaga acatgggaca     1260

ggctctcagc cccgacatgc tggccactga ccttgcctat tacctggtcc gcaaagggat     1320

gccattccgc caggcccacg aggcctccgg gaaagctgtg ttcatggccg agaccaaggg     1380

ggtcgccctc aaccagctgt cactgcagga gctgcagacc atcagccccc tgttctcggg     1440

cgacgtgatc tgcgtgtggg actacgggca cagtgtggag cagtatggtg ccctgggcgg     1500

cactgcgcgc tccagcgtcg actggcagat ccgccaggtg cgggcgctac tgcaggcaca     1560

gcaggcctag gtcctcccac acctgccccc taataaagtg ggcgcgagag gaggctgctg     1620

tgtgtttcct gccccagcct ggctccctcg ttgctgggct ttcggggctg gccagtgggg     1680

acagtcaggg actggagagg cagggcaggg tggcctgtaa tcccagcact ttggaagggc     1740

aaggtgcgag gatgcttgag gccaggagtt tgacacagcc tgggcaacac agggagaccc     1800

ccatctctac tcaataataa aacaaatagc ctggcgtggt ggcccatgca tatagtccca     1860

gctacttgta aggctgaggt gagaggacac ttgtgcccag gagtggaggc tgcagtgagc     1920

tatgatcacg ccactgcatt ccagcctgga taacagagtg agaacctatc tctaaaaata     1980

aataaataaa cgaaaaataa a                                               2001


<210>  6
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
1               5                   10                  15      


Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
            20                  25                  30          


His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
        35                  40                  45              


Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
    50                  55                  60                  


His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
65                  70                  75                  80  


Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                85                  90                  95      


Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
            100                 105                 110         


Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
        115                 120                 125             


Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
    130                 135                 140                 


Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
145                 150                 155                 160 


Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser Gly 
                165                 170                 175     


Ala Ile Ala Gly Asn Pro Leu Gly Val Asp Arg Glu Leu Leu Arg Ala 
            180                 185                 190         


Glu Leu Asn Phe Gly Ala Ile Thr Leu Asn Ser Met Asp Ala Thr Ser 
        195                 200                 205             


Glu Arg Asp Phe Val Ala Glu Phe Leu Phe Trp Ala Ser Leu Cys Met 
    210                 215                 220                 


Thr His Leu Ser Arg Met Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys 
225                 230                 235                 240 


Glu Phe Ser Phe Val Gln Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser 
                245                 250                 255     


Leu Met Pro Gln Lys Lys Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser 
            260                 265                 270         


Lys Ala Gly Arg Val Phe Gly Arg Cys Ala Gly Leu Leu Met Thr Leu 
        275                 280                 285             


Lys Gly Leu Pro Ser Thr Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu 
    290                 295                 300                 


Ala Val Phe Glu Val Ser Asp Thr Met Ser Ala Val Leu Gln Val Ala 
305                 310                 315                 320 


Thr Gly Val Ile Ser Thr Leu Gln Ile His Gln Glu Asn Met Gly Gln 
                325                 330                 335     


Ala Leu Ser Pro Asp Met Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val 
            340                 345                 350         


Arg Lys Gly Met Pro Phe Arg Gln Ala His Glu Ala Ser Gly Lys Ala 
        355                 360                 365             


Val Phe Met Ala Glu Thr Lys Gly Val Ala Leu Asn Gln Leu Ser Leu 
    370                 375                 380                 


Gln Glu Leu Gln Thr Ile Ser Pro Leu Phe Ser Gly Asp Val Ile Cys 
385                 390                 395                 400 


Val Trp Asp Tyr Gly His Ser Val Glu Gln Tyr Gly Ala Leu Gly Gly 
                405                 410                 415     


Thr Ala Arg Ser Ser Val Asp Trp Gln Ile Arg Gln Val Arg Ala Leu 
            420                 425                 430         


Leu Gln Ala Gln Gln Ala 
        435             


<210>  7
<211>  1983
<212>  DNA
<213>  Homo sapiens

<400>  7
ccaggcggag gtgagtgcgc ggcggccgga tgggcgggac gggcgtggag gacgccgagc       60

accgtggcgc gcgctcacgt ccgcgtcccc aagggctgcg ctccctcaag cgcagtgccc      120

agaactcgga gccagcccgg cccgggggac cctgctggcc aaggaggtcg tcagtccggt      180

cttgtcttcc agacccggag gaccgaagct tccggacgac gaggaaccgc ccaacatggc      240

ctcggagagt gggaagcttt ggggtggccg gtttgtgggt gcagtggacc ccatcatgga      300

gaagttcaac gcgtccattg cctacgaccg gcacctttgg gaggtggatg ttcaaggcag      360

caaagcctac agcaggggcc tggagaaggc agggctcctc accaaggccg agatggacca      420

gatactccat ggcctagaca aggtggctga ggagtgggcc cagggcacct tcaaactgaa      480

ctccaatgat gaggacatcc acacagccaa tgagcgccgc ctgaaggagc tcattggtgc      540

aacggcaggg aagctgcaca cgggacggag ccggaatgac caggtggtca cagacctcag      600

gctgtggatg cggcagacct gctccacgct ctcgggcctc ctctgggagc tcattaggac      660

catggtggat cgggcagagg cggaacgtga tgttctcttc ccggggtaca cccatttgca      720

gagggcccag cccatccgct ggagccactg gattctgagt ggggccattg caggcaatcc      780

cctgggtgtg gaccgagagc tgctccgagc agaactcaac tttggggcca tcactctcaa      840

cagcatggat gccactagtg agcgggactt tgtggccgag ttcctgttct gggcttcgct      900

gtgcatgacc catctcagca ggatggccga ggacctcatc ctctactgca ccaaggaatt      960

cagcttcgtg cagctctcag atgcctacag cacgggaagc agcctgatgc cccagaagaa     1020

aaaccccgac agtttggagc tgatccggag caaggctggg cgtgtgtttg ggcggtgtgc     1080

cgggctcctg atgaccctca agggacttcc cagcacctac aacaaagact tacaggagga     1140

caaggaagct gtgtttgaag tgtcagacac tatgagtgcc gtgctccagg tggccactgg     1200

cgtcatctct acgctgcaga ttcaccaaga gaacatggga caggctctca gccccgacat     1260

gctggccact gaccttgcct attacctggt ccgcaaaggg atgccattcc gccaggccca     1320

cgaggcctcc gggaaagctg tgttcatggc cgagaccaag ggggtcgccc tcaaccagct     1380

gtcactgcag gagctgcaga ccatcagccc cctgttctcg ggcgacgtga tctgcgtgtg     1440

ggactacggg cacagtgtgg agcagtatgg tgccctgggc ggcactgcgc gctccagcgt     1500

cgactggcag atccgccagg tgcgggcgct actgcaggca cagcaggcct aggtcctccc     1560

acacctgccc cctaataaag tgggcgcgag aggaggctgc tgtgtgtttc ctgccccagc     1620

ctggctccct cgttgctggg ctttcggggc tggccagtgg ggacagtcag ggactggaga     1680

ggcagggcag ggtggcctgt aatcccagca ctttggaagg gcaaggtgcg aggatgcttg     1740

aggccaggag tttgacacag cctgggcaac acagggagac ccccatctct actcaataat     1800

aaaacaaata gcctggcgtg gtggcccatg catatagtcc cagctacttg taaggctgag     1860

gtgagaggac acttgtgccc aggagtggag gctgcagtga gctatgatca cgccactgca     1920

ttccagcctg gataacagag tgagaaccta tctctaaaaa taaataaata aacgaaaaat     1980

aaa                                                                   1983


